ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 249/6338 495/18639 0.503030303030303 1.47932815054936 2.93084837845233e-14 4.03577821712885e-11 GO:0004674 protein serine/threonine kinase activity 212/6338 433/18639 0.489607390300231 1.43985360489208 6.15331465715197e-11 4.23655714144913e-08 GO:0140297 DNA-binding transcription factor binding 232/6338 488/18639 0.475409836065574 1.39810096788044 2.73931121257437e-10 1.25734384657164e-07 GO:0106310 protein serine kinase activity 179/6338 361/18639 0.49584487534626 1.45819700719138 5.38173988462091e-10 1.85266395528075e-07 GO:0044389 ubiquitin-like protein ligase binding 162/6338 322/18639 0.503105590062112 1.47954955714227 9.15067838454721e-10 2.5200968271043e-07 GO:0003714 transcription corepressor activity 111/6338 204/18639 0.544117647058823 1.60015917064207 1.49590802630225e-09 3.43310892036367e-07 GO:0019787 ubiquitin-like protein transferase activity 223/6338 479/18639 0.465553235908142 1.36911435217606 5.93762689252995e-09 1.16801603300196e-06 GO:0016755 aminoacyltransferase activity 229/6338 496/18639 0.461693548387097 1.35776365547288 9.05336332320238e-09 1.39076079649281e-06 GO:0140996 histone H3 kinase activity 173/6338 357/18639 0.484593837535014 1.42510958312009 9.08993984635822e-09 1.39076079649281e-06 GO:0035173 histone kinase activity 174/6338 360/18639 0.483333333333333 1.42140265067845 1.04663383756663e-08 1.43144772350968e-06 GO:0031625 ubiquitin protein ligase binding 150/6338 302/18639 0.496688741721854 1.4606786773357 1.14349491347905e-08 1.43144772350968e-06 GO:0060589 nucleoside-triphosphatase regulator activity 226/6338 490/18639 0.461224489795918 1.356384232456 1.25794389096904e-08 1.44349061488697e-06 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 169/6338 349/18639 0.484240687679083 1.42407102834497 1.43503958829672e-08 1.449230809309e-06 GO:0141003 histone H2AX kinase activity 171/6338 354/18639 0.483050847457627 1.42057190687326 1.47343727889078e-08 1.449230809309e-06 GO:0030695 GTPase regulator activity 225/6338 489/18639 0.460122699386503 1.35314405078338 1.7334542980444e-08 1.59131104560476e-06 GO:0051020 GTPase binding 154/6338 315/18639 0.488888888888889 1.4377406121805 2.81796555419378e-08 2.42521160507802e-06 GO:0001221 transcription coregulator binding 67/6338 115/18639 0.582608695652174 1.71335491925858 8.14477242141837e-08 6.34608853417217e-06 GO:0019902 phosphatase binding 100/6338 190/18639 0.526315789473684 1.54780687914169 8.88039987813724e-08 6.34608853417217e-06 GO:0004842 ubiquitin-protein transferase activity 206/6338 449/18639 0.458797327394209 1.3492463529979 9.03588186166535e-08 6.34608853417217e-06 GO:0031267 small GTPase binding 139/6338 283/18639 0.491166077738516 1.44443744445696 9.21726729727258e-08 6.34608853417217e-06 GO:0046332 SMAD binding 49/6338 79/18639 0.620253164556962 1.82406101833026 3.20263900632942e-07 2.100016148436e-05 GO:0035091 phosphatidylinositol binding 137/6338 284/18639 0.482394366197183 1.41864130507247 4.26744728217775e-07 2.67103404889035e-05 GO:0003713 transcription coactivator activity 125/6338 256/18639 0.48828125 1.43595364764121 5.9852966536492e-07 3.58337108351085e-05 GO:0140857 histone H3T45 kinase activity 120/6338 246/18639 0.48780487804878 1.43455271725327 1.06102523226626e-06 4.94635018257189e-05 GO:0035402 histone H3T11 kinase activity 120/6338 247/18639 0.48582995951417 1.4287448115154 1.37774391763274e-06 4.94635018257189e-05 GO:0035403 histone H3T6 kinase activity 120/6338 247/18639 0.48582995951417 1.4287448115154 1.37774391763274e-06 4.94635018257189e-05 GO:0004676 3-phosphoinositide-dependent protein kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0004711 ribosomal protein S6 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0035175 histone H3S10 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0035979 histone H2AXS139 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0044022 histone H3S28 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0044023 histone H4S1 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0044024 histone H2AS1 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0044025 histone H2BS14 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0072354 histone H3T3 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0072371 histone H2AS121 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0072518 Rho-dependent protein serine/threonine kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0140823 histone H2BS36 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0140855 histone H3S57 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0140995 histone H2A kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0140997 histone H4 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0140998 histone H2B kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:1990244 histone H2AT120 kinase activity 119/6338 245/18639 0.485714285714286 1.42840463417933 1.54461189433981e-06 4.94635018257189e-05 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 118/6338 243/18639 0.48559670781893 1.42805885721632 1.73168916905006e-06 5.31494334592962e-05 GO:0051019 mitogen-activated protein kinase binding 22/6338 28/18639 0.785714285714286 2.31065455529009 1.73690959017308e-06 5.31494334592962e-05 GO:0004679 AMP-activated protein kinase activity 120/6338 248/18639 0.483870967741935 1.42298374372703 1.78228721392237e-06 5.33523802950239e-05 GO:0004677 DNA-dependent protein kinase activity 119/6338 246/18639 0.483739837398374 1.42259811127616 1.99773640447169e-06 5.75461937055558e-05 GO:0001217 DNA-binding transcription repressor activity 132/6338 278/18639 0.474820143884892 1.39636678161415 2.00596753657711e-06 5.75461937055558e-05 GO:0005518 collagen binding 44/6338 72/18639 0.611111111111111 1.79717576522562 2.26627681927819e-06 6.36870036764503e-05 GO:0001540 amyloid-beta binding 49/6338 83/18639 0.590361445783133 1.73615446323001 2.56937697515001e-06 7.07606418956312e-05 GO:0001223 transcription coactivator binding 30/6338 44/18639 0.681818181818182 2.00511345706991 3.79809455216851e-06 0.00010254855290855 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 126/6338 268/18639 0.470149253731343 1.38263047338254 6.28046272960125e-06 0.000166311484205018 GO:0061659 ubiquitin-like protein ligase activity 167/6338 372/18639 0.448924731182796 1.32021269556897 7.13746870083051e-06 0.000185439517000823 GO:0019207 kinase regulator activity 133/6338 287/18639 0.463414634146341 1.36282508139061 8.81970358058505e-06 0.000224902441304919 GO:0005085 guanyl-nucleotide exchange factor activity 110/6338 230/18639 0.478260869565217 1.40648538148092 9.18373786671554e-06 0.000229927400772133 GO:0001968 fibronectin binding 22/6338 30/18639 0.733333333333333 2.15661091827075 1.23862688775712e-05 0.000304569504364563 GO:0005178 integrin binding 81/6338 161/18639 0.503105590062112 1.47954955714227 1.36440963826715e-05 0.000329612644191905 GO:0050840 extracellular matrix binding 40/6338 67/18639 0.597014925373134 1.75572123604131 1.44562431124784e-05 0.000343211151135909 GO:0005096 GTPase activator activity 125/6338 271/18639 0.461254612546125 1.35647281843598 2.12290640602442e-05 0.000495464766287395 GO:0032182 ubiquitin-like protein binding 63/6338 120/18639 0.525 1.54393736194383 2.24438323489212e-05 0.000515085952407743 GO:0019903 protein phosphatase binding 73/6338 144/18639 0.506944444444444 1.49083898706216 2.55516546711913e-05 0.000576797188233285 GO:0005543 phospholipid binding 212/6338 497/18639 0.426559356136821 1.25443986100256 2.95853190785397e-05 0.00065129494610285 GO:0019887 protein kinase regulator activity 118/6338 255/18639 0.462745098039216 1.36085608746496 2.97978079916336e-05 0.00065129494610285 GO:0005525 GTP binding 166/6338 378/18639 0.439153439153439 1.2914769568288 3.37830395841993e-05 0.000726863211053788 GO:0061630 ubiquitin protein ligase activity 156/6338 353/18639 0.441926345609065 1.29963161183455 3.87582532200173e-05 0.000821078687445598 GO:0003924 GTPase activity 147/6338 331/18639 0.444108761329305 1.30604973215792 4.75214207453546e-05 0.000990352271644712 GO:0050431 transforming growth factor beta binding 18/6338 24/18639 0.75 2.2056248027769 4.81870749456759e-05 0.000990352271644712 GO:0005201 extracellular matrix structural constituent 82/6338 168/18639 0.488095238095238 1.43540661768021 4.9205216339798e-05 0.000996405630880909 GO:0003779 actin binding 190/6338 443/18639 0.428893905191874 1.26130538006805 5.16400871760166e-05 0.00103055652233877 GO:0019003 GDP binding 42/6338 75/18639 0.56 1.64686651940675 7.45535721161719e-05 0.00146657526862812 GO:0019955 cytokine binding 71/6338 144/18639 0.493055555555556 1.44999408330704 0.000102482852969677 0.001987589979426 GO:0019001 guanyl nucleotide binding 171/6338 400/18639 0.4275 1.25720613758283 0.000145730537624602 0.0027489171275216 GO:0032561 guanyl ribonucleotide binding 171/6338 400/18639 0.4275 1.25720613758283 0.000145730537624602 0.0027489171275216 GO:0016922 nuclear receptor binding 67/6338 137/18639 0.489051094890511 1.43821763295428 0.000214300777003985 0.00398773202614171 GO:0050321 tau-protein kinase activity 16/6338 22/18639 0.727272727272727 2.13878768754124 0.000236565688365046 0.00434334603838225 GO:0004713 protein tyrosine kinase activity 68/6338 140/18639 0.485714285714286 1.42840463417933 0.000248774808827787 0.00450740673362978 GO:0001222 transcription corepressor binding 29/6338 49/18639 0.591836734693878 1.74049304164708 0.000264738228899387 0.00473434469083709 GO:1901981 phosphatidylinositol phosphate binding 86/6338 185/18639 0.464864864864865 1.3670899678473 0.000277652196019045 0.00490162915279775 GO:0019838 growth factor binding 66/6338 136/18639 0.485294117647059 1.42716899003211 0.000313844473408099 0.00547042835294877 GO:0043130 ubiquitin binding 51/6338 100/18639 0.51 1.49982486588829 0.000331298609863167 0.00570247732226977 GO:0048156 tau protein binding 26/6338 43/18639 0.604651162790698 1.77817813557208 0.000340212570889417 0.00578361370512009 GO:0042393 histone binding 110/6338 247/18639 0.445344129554656 1.30968274388912 0.000351694375253282 0.00590589213077768 GO:0099122 RNA polymerase II C-terminal domain binding 9/6338 10/18639 0.9 2.64674976333228 0.000420391875456708 0.00697445316269743 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 102/6338 229/18639 0.445414847161572 1.30989071256619 0.000559996831114682 0.00917994805291568 GO:0002020 protease binding 65/6338 136/18639 0.477941176470588 1.40554521745587 0.000586783860320755 0.00950589853719622 GO:0035591 signaling adaptor activity 62/6338 129/18639 0.48062015503876 1.41342364622396 0.000646399397442126 0.0102430908032187 GO:0001098 basal transcription machinery binding 33/6338 60/18639 0.55 1.61745818870306 0.000662044358377967 0.0102430908032187 GO:0001099 basal RNA polymerase II transcription machinery binding 33/6338 60/18639 0.55 1.61745818870306 0.000662044358377967 0.0102430908032187 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 33/6338 60/18639 0.55 1.61745818870306 0.000662044358377967 0.0102430908032187 GO:0004725 protein tyrosine phosphatase activity 49/6338 98/18639 0.5 1.4704165351846 0.000767088570335897 0.0115969514453831 GO:0035401 histone H3Y41 kinase activity 56/6338 115/18639 0.48695652173913 1.43205784296239 0.000774814475653776 0.0115969514453831 GO:0140801 histone H2AXY142 kinase activity 56/6338 115/18639 0.48695652173913 1.43205784296239 0.000774814475653776 0.0115969514453831 GO:0005161 platelet-derived growth factor receptor binding 11/6338 14/18639 0.785714285714286 2.31065455529009 0.000834273979717809 0.0123273670200975 GO:0008175 tRNA methyltransferase activity 21/6338 34/18639 0.617647058823529 1.81639689640451 0.000847746463970012 0.0123273670200975 GO:0004860 protein kinase inhibitor activity 43/6338 84/18639 0.511904761904762 1.505426452689 0.000850471944015438 0.0123273670200975 GO:0140030 modification-dependent protein binding 79/6338 173/18639 0.456647398843931 1.34292377201831 0.000927652183400853 0.013306011005656 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 12/6338 16/18639 0.75 2.2056248027769 0.000966754428358887 0.0137239262664968 GO:0032934 sterol binding 36/6338 68/18639 0.529411764705882 1.55691162548958 0.000994492661003239 0.0139736366755251 GO:0019789 SUMO transferase activity 18/6338 28/18639 0.642857142857143 1.89053554523734 0.00101646001919825 0.0141380348124848 GO:0019210 kinase inhibitor activity 45/6338 90/18639 0.5 1.4704165351846 0.00123330868924111 0.01698266065085 GO:0032266 phosphatidylinositol-3-phosphate binding 27/6338 48/18639 0.5625 1.65421860208268 0.00127181557695983 0.0173395054403335 GO:1990782 protein tyrosine kinase binding 56/6338 117/18639 0.478632478632479 1.40757822171517 0.00129937583908879 0.0175086339746151 GO:0023023 MHC protein complex binding 22/6338 37/18639 0.594594594594595 1.74860344724655 0.00132236596467681 0.0175086339746151 GO:0043394 proteoglycan binding 22/6338 37/18639 0.594594594594595 1.74860344724655 0.00132236596467681 0.0175086339746151 GO:0033218 amide binding 107/6338 247/18639 0.433198380566802 1.27396412360123 0.00136696143598321 0.0179267228318941 GO:0030971 receptor tyrosine kinase binding 41/6338 81/18639 0.506172839506173 1.48856982574244 0.00147299528946283 0.0191350425810407 GO:0019107 myristoyltransferase activity 9/6338 11/18639 0.818181818181818 2.40613614848389 0.00160832862142456 0.0206978365579591 GO:0019209 kinase activator activity 68/6338 148/18639 0.459459459459459 1.35119357287234 0.00166489701296855 0.021227436915349 GO:0016407 acetyltransferase activity 47/6338 96/18639 0.489583333333333 1.43978285736825 0.00171170820158647 0.0216240568218767 GO:0000149 SNARE binding 51/6338 106/18639 0.481132075471698 1.41492911876254 0.00181059643905809 0.0226653754234818 GO:0016417 S-acyltransferase activity 18/6338 29/18639 0.620689655172414 1.82534466436709 0.00183149188625515 0.0227203993457058 GO:0031994 insulin-like growth factor I binding 10/6338 13/18639 0.769230769230769 2.26217928489939 0.00195257180205424 0.0238330542993082 GO:0097110 scaffold protein binding 36/6338 70/18639 0.514285714285714 1.51242843618987 0.00195579893668978 0.0238330542993082 GO:0019706 protein-cysteine S-palmitoyltransferase activity 16/6338 25/18639 0.64 1.88213316503629 0.00207818304426314 0.0246694659650892 GO:0019707 protein-cysteine S-acyltransferase activity 16/6338 25/18639 0.64 1.88213316503629 0.00207818304426314 0.0246694659650892 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 16/6338 25/18639 0.64 1.88213316503629 0.00207818304426314 0.0246694659650892 GO:0005158 insulin receptor binding 15/6338 23/18639 0.652173913043478 1.91793461111035 0.002180777749365 0.0256660765886804 GO:0015485 cholesterol binding 29/6338 54/18639 0.537037037037037 1.57933627853161 0.00224847757173088 0.0262385899684188 GO:0004715 non-membrane spanning protein tyrosine kinase activity 25/6338 45/18639 0.555555555555556 1.63379615020511 0.0024037445850536 0.027814758769906 GO:0070063 RNA polymerase binding 31/6338 59/18639 0.525423728813559 1.54518347765161 0.00254293557060265 0.0291801856726654 GO:0004712 protein serine/threonine/tyrosine kinase activity 24/6338 43/18639 0.558139534883721 1.64139520206653 0.00268552790421244 0.0305617514388474 GO:0004197 cysteine-type endopeptidase activity 43/6338 88/18639 0.488636363636364 1.43699797756677 0.00275627838706584 0.031109797860571 GO:0051213 dioxygenase activity 45/6338 93/18639 0.483870967741935 1.42298374372703 0.00283798171601546 0.0315153292173652 GO:0051219 phosphoprotein binding 45/6338 93/18639 0.483870967741935 1.42298374372703 0.00283798171601546 0.0315153292173652 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 59/6338 128/18639 0.4609375 1.3555402433733 0.00296669235143244 0.0326810829433797 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 22/6338 39/18639 0.564102564102564 1.65893147559288 0.00334454127421871 0.0365510582111045 GO:0046966 nuclear thyroid hormone receptor binding 17/6338 28/18639 0.607142857142857 1.78550579272416 0.00341616862191871 0.0370398755305675 GO:0030295 protein kinase activator activity 63/6338 139/18639 0.453237410071942 1.33289556426806 0.00357566924891689 0.0381371918981662 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 43/6338 89/18639 0.48314606741573 1.42085193287501 0.00360046110875934 0.0381371918981662 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 43/6338 89/18639 0.48314606741573 1.42085193287501 0.00360046110875934 0.0381371918981662 GO:0004721 phosphoprotein phosphatase activity 77/6338 175/18639 0.44 1.29396655096245 0.00367121693596719 0.0383769012371389 GO:0005160 transforming growth factor beta receptor binding 16/6338 26/18639 0.615384615384615 1.80974342791951 0.00370670142668081 0.0383769012371389 GO:0008198 ferrous iron binding 16/6338 26/18639 0.615384615384615 1.80974342791951 0.00370670142668081 0.0383769012371389 GO:0035035 histone acetyltransferase binding 15/6338 24/18639 0.625 1.83802066898075 0.00399583233544281 0.041061650193319 GO:0140035 ubiquitin-like protein reader activity 14/6338 22/18639 0.636363636363636 1.87143922659858 0.00427151218801019 0.043569424317704 GO:0008603 cAMP-dependent protein kinase regulator activity 9/6338 12/18639 0.75 2.2056248027769 0.00448419245410018 0.0444202225336206 GO:0035497 cAMP response element binding 9/6338 12/18639 0.75 2.2056248027769 0.00448419245410018 0.0444202225336206 GO:0016004 phospholipase activator activity 13/6338 20/18639 0.65 1.91154149573998 0.00451603214780115 0.0444202225336206 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 13/6338 20/18639 0.65 1.91154149573998 0.00451603214780115 0.0444202225336206 GO:0043175 RNA polymerase core enzyme binding 23/6338 42/18639 0.547619047619048 1.61045620520218 0.00451621725105801 0.0444202225336206 GO:0140793 histone H2AXY142 phosphatase activity 43/6338 90/18639 0.477777777777778 1.4050646891764 0.00465654400563088 0.0454756106081824 GO:0005545 1-phosphatidylinositol binding 10/6338 14/18639 0.714285714285714 2.10059505026372 0.00474831635789532 0.0455670091866697 GO:0008191 metalloendopeptidase inhibitor activity 10/6338 14/18639 0.714285714285714 2.10059505026372 0.00474831635789532 0.0455670091866697 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 11/6338 16/18639 0.6875 2.02182273587883 0.0047982689412252 0.0455670091866697 GO:0070411 I-SMAD binding 11/6338 16/18639 0.6875 2.02182273587883 0.0047982689412252 0.0455670091866697 GO:0008234 cysteine-type peptidase activity 81/6338 187/18639 0.433155080213904 1.27383678449147 0.00487123950097159 0.0459431287180677 GO:0003925 G protein activity 28/6338 54/18639 0.518518518518518 1.5248764068581 0.00513120927990076 0.0480658175402948 GO:0042578 phosphoric ester hydrolase activity 147/6338 363/18639 0.40495867768595 1.19091587147183 0.00534602813987571 0.0497397347878976 GO:0140789 histone phosphatase activity 61/6338 136/18639 0.448529411764706 1.31905012715089 0.00544104516197479 0.0502840213962368 GO:0140034 methylation-dependent protein binding 37/6338 76/18639 0.486842105263158 1.43172136320606 0.00566676081979434 0.052020864325712 GO:0030159 signaling receptor complex adaptor activity 27/6338 52/18639 0.519230769230769 1.52697101730709 0.0057959620871348 0.0528545681720836 GO:0000993 RNA polymerase II complex binding 20/6338 36/18639 0.555555555555556 1.63379615020511 0.00638094869193419 0.0570556256415154 GO:0016409 palmitoyltransferase activity 20/6338 36/18639 0.555555555555556 1.63379615020511 0.00638094869193419 0.0570556256415154 GO:0044390 ubiquitin-like protein conjugating enzyme binding 20/6338 36/18639 0.555555555555556 1.63379615020511 0.00638094869193419 0.0570556256415154 GO:0051117 ATPase binding 40/6338 84/18639 0.476190476190476 1.40039670017581 0.00665268169988673 0.0591015658112518 GO:0000030 mannosyltransferase activity 15/6338 25/18639 0.6 1.76449984222152 0.00687230627221231 0.0602749409989576 GO:0042974 nuclear retinoic acid receptor binding 15/6338 25/18639 0.6 1.76449984222152 0.00687230627221231 0.0602749409989576 GO:0140313 molecular sequestering activity 28/6338 55/18639 0.509090909090909 1.49715138127887 0.00710571059637062 0.0619276170329262 GO:0001727 lipid kinase activity 22/6338 41/18639 0.536585365853659 1.5780079889786 0.00746806510916436 0.0646762619831404 GO:0051010 microtubule plus-end binding 13/6338 21/18639 0.619047619047619 1.82051571022855 0.00818760879325349 0.0704646081769379 GO:0030291 protein serine/threonine kinase inhibitor activity 24/6338 46/18639 0.521739130434783 1.53434768888828 0.00837032480753767 0.0715896724222321 GO:0016791 phosphatase activity 112/6338 273/18639 0.41025641025641 1.20649561861301 0.00876261891200255 0.0742117311017223 GO:0005520 insulin-like growth factor binding 12/6338 19/18639 0.631578947368421 1.85736825497002 0.00883857944857114 0.0742117311017223 GO:0043395 heparan sulfate proteoglycan binding 12/6338 19/18639 0.631578947368421 1.85736825497002 0.00883857944857114 0.0742117311017223 GO:0031624 ubiquitin conjugating enzyme binding 17/6338 30/18639 0.566666666666667 1.66647207320921 0.00896811955836629 0.0748430341325478 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 11/6338 17/18639 0.647058823529412 1.90289198670948 0.00943621956636839 0.0773432996600552 GO:0032977 membrane insertase activity 11/6338 17/18639 0.647058823529412 1.90289198670948 0.00943621956636839 0.0773432996600552 GO:0046965 nuclear retinoid X receptor binding 11/6338 17/18639 0.647058823529412 1.90289198670948 0.00943621956636839 0.0773432996600552 GO:0120283 protein serine/threonine kinase binding 10/6338 15/18639 0.666666666666667 1.96055538024613 0.00991674364642674 0.0799108204876247 GO:0032794 GTPase activating protein binding 8/6338 11/18639 0.727272727272727 2.13878768754124 0.0100714552367613 0.0799108204876247 GO:0034713 type I transforming growth factor beta receptor binding 8/6338 11/18639 0.727272727272727 2.13878768754124 0.0100714552367613 0.0799108204876247 GO:0097493 structural molecule activity conferring elasticity 8/6338 11/18639 0.727272727272727 2.13878768754124 0.0100714552367613 0.0799108204876247 GO:0180030 inositol phosphate kinase activity 8/6338 11/18639 0.727272727272727 2.13878768754124 0.0100714552367613 0.0799108204876247 GO:0019905 syntaxin binding 30/6338 61/18639 0.491803278688525 1.44631134608321 0.0100976635910288 0.0799108204876247 GO:0043548 phosphatidylinositol 3-kinase binding 15/6338 26/18639 0.576923076923077 1.69663446367454 0.0111890401524825 0.087046939491347 GO:0050681 nuclear androgen receptor binding 15/6338 26/18639 0.576923076923077 1.69663446367454 0.0111890401524825 0.087046939491347 GO:0097602 cullin family protein binding 15/6338 26/18639 0.576923076923077 1.69663446367454 0.0111890401524825 0.087046939491347 GO:0019783 ubiquitin-like protein peptidase activity 56/6338 127/18639 0.440944881889764 1.29674529087146 0.0113055346815601 0.0874591081826305 GO:0071889 14-3-3 protein binding 18/6338 33/18639 0.545454545454545 1.60409076565593 0.0120964167140868 0.0912831308243592 GO:0035064 methylated histone binding 35/6338 74/18639 0.472972972972973 1.39093456030976 0.0121030641131494 0.0912831308243592 GO:0032451 demethylase activity 21/6338 40/18639 0.525 1.54393736194383 0.0121313093252416 0.0912831308243592 GO:0061791 GTPase motor activity 21/6338 40/18639 0.525 1.54393736194383 0.0121313093252416 0.0912831308243592 GO:1990606 membrane scission GTPase motor activity 21/6338 40/18639 0.525 1.54393736194383 0.0121313093252416 0.0912831308243592 GO:0060229 lipase activator activity 14/6338 24/18639 0.583333333333333 1.71548595771537 0.0124628725525466 0.0932683451350904 GO:0015631 tubulin binding 152/6338 385/18639 0.394805194805195 1.16105617323667 0.0132760505971389 0.0985824042263315 GO:0043178 alcohol binding 42/6338 92/18639 0.456521739130435 1.34255422777724 0.0133161417473476 0.0985824042263315 GO:0017147 Wnt-protein binding 17/6338 31/18639 0.548387096774194 1.6127149095573 0.0136474591052027 0.0999603786588516 GO:0070325 lipoprotein particle receptor binding 17/6338 31/18639 0.548387096774194 1.6127149095573 0.0136474591052027 0.0999603786588516 GO:0015605 organophosphate ester transmembrane transporter activity 25/6338 50/18639 0.5 1.4704165351846 0.0140540930186304 0.102394106278593 GO:0043236 laminin binding 16/6338 29/18639 0.551724137931034 1.62252859054852 0.0153958830023139 0.111579636285191 GO:0005484 SNAP receptor activity 19/6338 36/18639 0.527777777777778 1.55210634269486 0.0155726047586405 0.112269511793969 GO:0034212 protein N-acetyltransferase activity 26/6338 53/18639 0.490566037735849 1.44267282697357 0.0165992516710078 0.118430930315947 GO:0140296 general transcription initiation factor binding 26/6338 53/18639 0.490566037735849 1.44267282697357 0.0165992516710078 0.118430930315947 GO:0070064 proline-rich region binding 11/6338 18/18639 0.611111111111111 1.79717576522562 0.0168729016007846 0.119762811877734 GO:0005044 scavenger receptor activity 15/6338 27/18639 0.555555555555556 1.63379615020511 0.0173646931195017 0.121995828701806 GO:0023026 MHC class II protein complex binding 15/6338 27/18639 0.555555555555556 1.63379615020511 0.0173646931195017 0.121995828701806 GO:0004707 MAP kinase activity 10/6338 16/18639 0.625 1.83802066898075 0.0184475348217627 0.128294219442258 GO:0005024 transforming growth factor beta receptor activity 10/6338 16/18639 0.625 1.83802066898075 0.0184475348217627 0.128294219442258 GO:0004709 MAP kinase kinase kinase activity 14/6338 25/18639 0.56 1.64686651940675 0.0195781387275175 0.135379989260656 GO:0042813 Wnt receptor activity 9/6338 14/18639 0.642857142857143 1.89053554523734 0.0199579795351584 0.135379989260656 GO:0046030 inositol trisphosphate phosphatase activity 9/6338 14/18639 0.642857142857143 1.89053554523734 0.0199579795351584 0.135379989260656 GO:0061665 SUMO ligase activity 9/6338 14/18639 0.642857142857143 1.89053554523734 0.0199579795351584 0.135379989260656 GO:0071933 Arp2/3 complex binding 9/6338 14/18639 0.642857142857143 1.89053554523734 0.0199579795351584 0.135379989260656 GO:0140098 catalytic activity, acting on RNA 151/6338 387/18639 0.390180878552972 1.14745683107429 0.0209726970425552 0.137070951700203 GO:0000995 RNA polymerase III general transcription initiation factor activity 8/6338 12/18639 0.666666666666667 1.96055538024613 0.0212459808020835 0.137070951700203 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 186/6338 484/18639 0.384297520661157 1.13015485762122 0.0216924038796952 0.137070951700203 GO:0004090 carbonyl reductase (NADPH) activity 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0004862 cAMP-dependent protein kinase inhibitor activity 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0005131 growth hormone receptor binding 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0005522 profilin binding 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0005528 FK506 binding 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0008239 dipeptidyl-peptidase activity 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0016427 tRNA (cytidine) methyltransferase activity 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0032395 MHC class II receptor activity 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0042975 peroxisome proliferator activated receptor binding 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0043422 protein kinase B binding 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0070513 death domain binding 7/6338 10/18639 0.7 2.05858314925844 0.0220275766153068 0.137070951700203 GO:0008080 N-acetyltransferase activity 32/6338 69/18639 0.463768115942029 1.36386461234514 0.0220454478632392 0.137070951700203 GO:0042171 lysophosphatidic acid acyltransferase activity 13/6338 23/18639 0.565217391304348 1.66220999629564 0.0220607479037845 0.137070951700203 GO:0071617 lysophospholipid acyltransferase activity 13/6338 23/18639 0.565217391304348 1.66220999629564 0.0220607479037845 0.137070951700203 GO:0045309 protein phosphorylated amino acid binding 28/6338 59/18639 0.474576271186441 1.39564959271759 0.0220985848056972 0.137070951700203 GO:0001965 G-protein alpha-subunit binding 16/6338 30/18639 0.533333333333333 1.56844430419691 0.0227418983668255 0.13980175915678 GO:0015215 nucleotide transmembrane transporter activity 16/6338 30/18639 0.533333333333333 1.56844430419691 0.0227418983668255 0.13980175915678 GO:0008017 microtubule binding 110/6338 276/18639 0.398550724637681 1.1720711512341 0.0235303904832095 0.144005989757242 GO:0001784 phosphotyrosine residue binding 23/6338 47/18639 0.48936170212766 1.43913107698918 0.0242359367865335 0.146372302434459 GO:0061733 protein-lysine-acetyltransferase activity 23/6338 47/18639 0.48936170212766 1.43913107698918 0.0242359367865335 0.146372302434459 GO:0140938 histone H3 methyltransferase activity 23/6338 47/18639 0.48936170212766 1.43913107698918 0.0242359367865335 0.146372302434459 GO:0005496 steroid binding 47/6338 108/18639 0.435185185185185 1.27980698432734 0.0246776316067118 0.148262765797433 GO:0005080 protein kinase C binding 25/6338 52/18639 0.480769230769231 1.41386205306212 0.0247642963931806 0.148262765797433 GO:0043015 gamma-tubulin binding 18/6338 35/18639 0.514285714285714 1.51242843618987 0.025001647301472 0.148393397991927 GO:0140566 histone reader activity 18/6338 35/18639 0.514285714285714 1.51242843618987 0.025001647301472 0.148393397991927 GO:0140597 protein carrier chaperone 77/6338 188/18639 0.409574468085106 1.20449014052356 0.0270454261901508 0.159834986540076 GO:0042826 histone deacetylase binding 54/6338 127/18639 0.425196850393701 1.25043295905462 0.0276774052798244 0.16287088491589 GO:0140036 ubiquitin-modified protein reader activity 11/6338 19/18639 0.578947368421053 1.70258756705585 0.0279200945600782 0.163543750433149 GO:0038024 cargo receptor activity 30/6338 65/18639 0.461538461538462 1.35730757093963 0.0280292847510699 0.163543750433149 GO:0005112 Notch binding 14/6338 26/18639 0.538461538461538 1.58352549942957 0.0293654203983915 0.16778499538832 GO:0008157 protein phosphatase 1 binding 14/6338 26/18639 0.538461538461538 1.58352549942957 0.0293654203983915 0.16778499538832 GO:0015216 purine nucleotide transmembrane transporter activity 14/6338 26/18639 0.538461538461538 1.58352549942957 0.0293654203983915 0.16778499538832 GO:0050750 low-density lipoprotein particle receptor binding 14/6338 26/18639 0.538461538461538 1.58352549942957 0.0293654203983915 0.16778499538832 GO:0070412 R-SMAD binding 14/6338 26/18639 0.538461538461538 1.58352549942957 0.0293654203983915 0.16778499538832 GO:0019208 phosphatase regulator activity 50/6338 117/18639 0.427350427350427 1.25676626938855 0.0300777559168294 0.171144916931711 GO:0001216 DNA-binding transcription activator activity 187/6338 491/18639 0.380855397148676 1.12003214696342 0.0303857484648756 0.171827887998719 GO:0043539 protein serine/threonine kinase activator activity 33/6338 73/18639 0.452054794520548 1.32941768934498 0.0304965014006775 0.171827887998719 GO:1990841 promoter-specific chromatin binding 31/6338 68/18639 0.455882352941176 1.34067389972714 0.0311187392436793 0.171827887998719 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 10/6338 17/18639 0.588235294117647 1.72990180609953 0.0313208423294688 0.171827887998719 GO:0008429 phosphatidylethanolamine binding 10/6338 17/18639 0.588235294117647 1.72990180609953 0.0313208423294688 0.171827887998719 GO:0008484 sulfuric ester hydrolase activity 10/6338 17/18639 0.588235294117647 1.72990180609953 0.0313208423294688 0.171827887998719 GO:0019198 transmembrane receptor protein phosphatase activity 10/6338 17/18639 0.588235294117647 1.72990180609953 0.0313208423294688 0.171827887998719 GO:0032183 SUMO binding 10/6338 17/18639 0.588235294117647 1.72990180609953 0.0313208423294688 0.171827887998719 GO:0051787 misfolded protein binding 10/6338 17/18639 0.588235294117647 1.72990180609953 0.0313208423294688 0.171827887998719 GO:0051018 protein kinase A binding 25/6338 53/18639 0.471698113207547 1.38718541055151 0.0320545148951207 0.175155027819767 GO:0140457 protein demethylase activity 16/6338 31/18639 0.516129032258065 1.51784932664217 0.0324426335792229 0.176575124263201 GO:0017124 SH3 domain binding 49/6338 115/18639 0.426086956521739 1.25305061259209 0.0333183479439747 0.180379934103791 GO:0001091 RNA polymerase II general transcription initiation factor binding 13/6338 24/18639 0.541666666666667 1.59295124644998 0.033403691500702 0.180379934103791 GO:0008238 exopeptidase activity 44/6338 102/18639 0.431372549019608 1.26859465780632 0.0339388139903074 0.182553698690052 GO:0031005 filamin binding 9/6338 15/18639 0.6 1.76449984222152 0.0350198333682558 0.185466295778181 GO:0061578 K63-linked deubiquitinase activity 9/6338 15/18639 0.6 1.76449984222152 0.0350198333682558 0.185466295778181 GO:0141050 histone H3K deacetylase activity 9/6338 15/18639 0.6 1.76449984222152 0.0350198333682558 0.185466295778181 GO:0141051 histone H4K deacetylase activity 9/6338 15/18639 0.6 1.76449984222152 0.0350198333682558 0.185466295778181 GO:0004518 nuclease activity 84/6338 209/18639 0.401913875598086 1.1819616167991 0.0351537423370409 0.185466295778181 GO:0042169 SH2 domain binding 20/6338 41/18639 0.48780487804878 1.43455271725327 0.0356098730085604 0.186761931513895 GO:0015026 coreceptor activity 28/6338 61/18639 0.459016393442623 1.34989058967767 0.0356705795120948 0.186761931513895 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 12/6338 22/18639 0.545454545454545 1.60409076565593 0.0380249715907244 0.198334795001619 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 8/6338 13/18639 0.615384615384615 1.80974342791951 0.0389510078114915 0.198650139838606 GO:0005172 vascular endothelial growth factor receptor binding 8/6338 13/18639 0.615384615384615 1.80974342791951 0.0389510078114915 0.198650139838606 GO:0005338 nucleotide-sugar transmembrane transporter activity 8/6338 13/18639 0.615384615384615 1.80974342791951 0.0389510078114915 0.198650139838606 GO:0017154 semaphorin receptor activity 8/6338 13/18639 0.615384615384615 1.80974342791951 0.0389510078114915 0.198650139838606 GO:0035325 Toll-like receptor binding 8/6338 13/18639 0.615384615384615 1.80974342791951 0.0389510078114915 0.198650139838606 GO:0051011 microtubule minus-end binding 8/6338 13/18639 0.615384615384615 1.80974342791951 0.0389510078114915 0.198650139838606 GO:0030332 cyclin binding 17/6338 34/18639 0.5 1.4704165351846 0.0392739022991129 0.199557798767079 GO:0031593 polyubiquitin modification-dependent protein binding 27/6338 59/18639 0.457627118644068 1.34580496440624 0.0402552474595819 0.203792190264133 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 19/6338 39/18639 0.487179487179487 1.43271354710294 0.0405523313531675 0.204544176825318 GO:1902936 phosphatidylinositol bisphosphate binding 47/6338 111/18639 0.423423423423423 1.24521760637254 0.0408388589804294 0.204559608673964 GO:0140463 chromatin-protein adaptor activity 25/6338 54/18639 0.462962962962963 1.36149679183759 0.0408524999167321 0.204559608673964 GO:0004519 endonuclease activity 53/6338 127/18639 0.417322834645669 1.2272767931462 0.0414963848239002 0.207030876458372 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 7/6338 11/18639 0.636363636363636 1.87143922659858 0.0429507890277616 0.210474151214333 GO:0003953 NAD+ nucleosidase activity 7/6338 11/18639 0.636363636363636 1.87143922659858 0.0429507890277616 0.210474151214333 GO:0005114 type II transforming growth factor beta receptor binding 7/6338 11/18639 0.636363636363636 1.87143922659858 0.0429507890277616 0.210474151214333 GO:0048185 activin binding 7/6338 11/18639 0.636363636363636 1.87143922659858 0.0429507890277616 0.210474151214333 GO:0140031 phosphorylation-dependent protein binding 7/6338 11/18639 0.636363636363636 1.87143922659858 0.0429507890277616 0.210474151214333 GO:0008173 RNA methyltransferase activity 30/6338 67/18639 0.447761194029851 1.31679092703099 0.043296326343652 0.21141504033762 GO:0000287 magnesium ion binding 91/6338 230/18639 0.395652173913043 1.16354699740695 0.0437434306394432 0.21284347699828 GO:0022884 macromolecule transmembrane transporter activity 16/6338 32/18639 0.5 1.4704165351846 0.0448522162096946 0.216707023581577 GO:0120015 sterol transfer activity 16/6338 32/18639 0.5 1.4704165351846 0.0448522162096946 0.216707023581577 GO:0003725 double-stranded RNA binding 33/6338 75/18639 0.44 1.29396655096245 0.0456105870340055 0.219600623586803 GO:0019213 deacetylase activity 18/6338 37/18639 0.486486486486487 1.43067554774718 0.0462267766778634 0.221791886708773 GO:0016859 cis-trans isomerase activity 20/6338 42/18639 0.476190476190476 1.40039670017581 0.0467639996061931 0.223590373117111 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 10/6338 18/18639 0.555555555555556 1.63379615020511 0.0493807682403241 0.234473509885953 GO:0008409 5'-3' exonuclease activity 10/6338 18/18639 0.555555555555556 1.63379615020511 0.0493807682403241 0.234473509885953 GO:0140101 catalytic activity, acting on a tRNA 57/6338 139/18639 0.410071942446043 1.20595312957586 0.049939522179683 0.235287484504864 GO:0140767 enzyme-substrate adaptor activity 57/6338 139/18639 0.410071942446043 1.20595312957586 0.049939522179683 0.235287484504864 GO:0098531 ligand-modulated transcription factor activity 27/6338 60/18639 0.45 1.32337488166614 0.0500648024400328 0.235287484504864 GO:0032452 histone demethylase activity 15/6338 30/18639 0.5 1.4704165351846 0.0512917926523712 0.239963546013577 GO:0005516 calmodulin binding 82/6338 207/18639 0.396135265700483 1.16496768971147 0.0517608949486904 0.239963546013577 GO:0033192 calmodulin-dependent protein phosphatase activity 35/6338 81/18639 0.432098765432099 1.27073033904842 0.0528024360509179 0.239963546013577 GO:0140791 histone H2AXS140 phosphatase activity 35/6338 81/18639 0.432098765432099 1.27073033904842 0.0528024360509179 0.239963546013577 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 35/6338 81/18639 0.432098765432099 1.27073033904842 0.0528024360509179 0.239963546013577 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 35/6338 81/18639 0.432098765432099 1.27073033904842 0.0528024360509179 0.239963546013577 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 35/6338 81/18639 0.432098765432099 1.27073033904842 0.0528024360509179 0.239963546013577 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 35/6338 81/18639 0.432098765432099 1.27073033904842 0.0528024360509179 0.239963546013577 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 35/6338 81/18639 0.432098765432099 1.27073033904842 0.0528024360509179 0.239963546013577 GO:1990439 MAP kinase serine/threonine phosphatase activity 35/6338 81/18639 0.432098765432099 1.27073033904842 0.0528024360509179 0.239963546013577 GO:0042605 peptide antigen binding 21/6338 45/18639 0.466666666666667 1.37238876617229 0.0530136471616417 0.240130895202568 GO:0004177 aminopeptidase activity 19/6338 40/18639 0.475 1.39689570842537 0.0532252637665185 0.240298977726216 GO:0061775 cohesin loader activity 62/6338 153/18639 0.405228758169935 1.19171013309079 0.0536126627533291 0.241256982389981 GO:0000295 adenine nucleotide transmembrane transporter activity 12/6338 23/18639 0.521739130434783 1.53434768888828 0.0554404883401135 0.246229782187441 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 12/6338 23/18639 0.521739130434783 1.53434768888828 0.0554404883401135 0.246229782187441 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 12/6338 23/18639 0.521739130434783 1.53434768888828 0.0554404883401135 0.246229782187441 GO:0140375 immune receptor activity 63/6338 156/18639 0.403846153846154 1.18764412457218 0.0556489936804833 0.246229782187441 GO:0004708 MAP kinase kinase activity 9/6338 16/18639 0.5625 1.65421860208268 0.0563270743566042 0.246229782187441 GO:0005159 insulin-like growth factor receptor binding 9/6338 16/18639 0.5625 1.65421860208268 0.0563270743566042 0.246229782187441 GO:0005521 lamin binding 9/6338 16/18639 0.5625 1.65421860208268 0.0563270743566042 0.246229782187441 GO:0015923 mannosidase activity 9/6338 16/18639 0.5625 1.65421860208268 0.0563270743566042 0.246229782187441 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 9/6338 16/18639 0.5625 1.65421860208268 0.0563270743566042 0.246229782187441 GO:0042277 peptide binding 97/6338 249/18639 0.389558232931727 1.14562573424021 0.0566363316328733 0.246798191957173 GO:0046875 ephrin receptor binding 14/6338 28/18639 0.5 1.4704165351846 0.0587449720494633 0.254376812931167 GO:0141052 histone H3 demethylase activity 14/6338 28/18639 0.5 1.4704165351846 0.0587449720494633 0.254376812931167 GO:0140693 molecular condensate scaffold activity 22/6338 48/18639 0.458333333333333 1.34788182391922 0.0592609785078929 0.255806794374196 GO:0140311 protein sequestering activity 16/6338 33/18639 0.484848484848485 1.42585845836083 0.0602747963382701 0.259369982993118 GO:0008237 metallopeptidase activity 73/6338 184/18639 0.396739130434783 1.16674355509213 0.0613825410139368 0.263313890891561 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 35/6338 82/18639 0.426829268292683 1.25523362759661 0.0627952874963083 0.267706225642156 GO:0033549 MAP kinase phosphatase activity 35/6338 82/18639 0.426829268292683 1.25523362759661 0.0627952874963083 0.267706225642156 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 11/6338 21/18639 0.523809523809524 1.54043637019339 0.0636472787918763 0.268202235369004 GO:0002039 p53 binding 30/6338 69/18639 0.434782608695652 1.27862307407357 0.0639791155522237 0.268202235369004 GO:0008013 beta-catenin binding 44/6338 106/18639 0.415094339622642 1.22072316128533 0.0641684599354295 0.268202235369004 GO:0004705 JUN kinase activity 8/6338 14/18639 0.571428571428571 1.68047604021097 0.064275045513269 0.268202235369004 GO:0032454 histone H3K9 demethylase activity 8/6338 14/18639 0.571428571428571 1.68047604021097 0.064275045513269 0.268202235369004 GO:0034236 protein kinase A catalytic subunit binding 8/6338 14/18639 0.571428571428571 1.68047604021097 0.064275045513269 0.268202235369004 GO:0042043 neurexin family protein binding 8/6338 14/18639 0.571428571428571 1.68047604021097 0.064275045513269 0.268202235369004 GO:0140674 ATP-dependent histone chaperone activity 61/6338 152/18639 0.401315789473684 1.18020274534554 0.0661412435898452 0.275155566233284 GO:0004536 DNA nuclease activity 28/6338 64/18639 0.4375 1.28661446828653 0.066563270534871 0.276077179296739 GO:0008168 methyltransferase activity 80/6338 204/18639 0.392156862745098 1.15326787073302 0.0671956853278037 0.276208688104596 GO:0004112 cyclic-nucleotide phosphodiesterase activity 13/6338 26/18639 0.5 1.4704165351846 0.0673973269449124 0.276208688104596 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 13/6338 26/18639 0.5 1.4704165351846 0.0673973269449124 0.276208688104596 GO:0052742 phosphatidylinositol kinase activity 13/6338 26/18639 0.5 1.4704165351846 0.0673973269449124 0.276208688104596 GO:0140318 protein transporter activity 19/6338 41/18639 0.463414634146341 1.36282508139061 0.0684385557847554 0.278038988963035 GO:0016411 acylglycerol O-acyltransferase activity 15/6338 31/18639 0.483870967741935 1.42298374372703 0.0689628792834479 0.278038988963035 GO:0004879 nuclear receptor activity 26/6338 59/18639 0.440677966101695 1.2959603360949 0.0691306485268787 0.278038988963035 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 17/6338 36/18639 0.472222222222222 1.38872672767435 0.0691471276491942 0.278038988963035 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 17/6338 36/18639 0.472222222222222 1.38872672767435 0.0691471276491942 0.278038988963035 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 17/6338 36/18639 0.472222222222222 1.38872672767435 0.0691471276491942 0.278038988963035 GO:0140658 ATP-dependent chromatin remodeler activity 63/6338 158/18639 0.39873417721519 1.17261065464088 0.0707071964234714 0.278038988963035 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 24/6338 54/18639 0.444444444444444 1.30703692016409 0.0716323494468854 0.278038988963035 GO:0005346 purine ribonucleotide transmembrane transporter activity 10/6338 19/18639 0.526315789473684 1.54780687914169 0.0732259612183751 0.278038988963035 GO:0042800 histone H3K4 methyltransferase activity 10/6338 19/18639 0.526315789473684 1.54780687914169 0.0732259612183751 0.278038988963035 GO:1990380 K48-linked deubiquitinase activity 10/6338 19/18639 0.526315789473684 1.54780687914169 0.0732259612183751 0.278038988963035 GO:0005025 transforming growth factor beta receptor activity, type I 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0005026 transforming growth factor beta receptor activity, type II 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0005527 macrolide binding 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0016361 activin receptor activity, type I 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0016362 activin receptor activity, type II 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0016840 carbon-nitrogen lyase activity 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0017002 activin receptor activity 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0034452 dynactin binding 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0035014 phosphatidylinositol 3-kinase regulator activity 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0070008 serine-type exopeptidase activity 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0141221 histone deacetylase activity, hydrolytic mechanism 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:1990459 transferrin receptor binding 7/6338 12/18639 0.583333333333333 1.71548595771537 0.0733375205437107 0.278038988963035 GO:0101005 deubiquitinase activity 47/6338 115/18639 0.408695652173913 1.20190568962915 0.0734975976634311 0.278038988963035 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 35/6338 83/18639 0.421686746987952 1.24011033087858 0.074068096647581 0.279429504338956 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 12/6338 24/18639 0.5 1.4704165351846 0.0774772851795249 0.290113788475814 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 12/6338 24/18639 0.5 1.4704165351846 0.0774772851795249 0.290113788475814 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 66/6338 167/18639 0.395209580838323 1.16224540505609 0.0775322252426286 0.290113788475814 GO:0016776 phosphotransferase activity, phosphate group as acceptor 18/6338 39/18639 0.461538461538462 1.35730757093963 0.0778492526962577 0.290510625915303 GO:0042562 hormone binding 39/6338 94/18639 0.414893617021277 1.22013286962126 0.0782859518262455 0.291350690985784 GO:0052866 phosphatidylinositol phosphate phosphatase activity 16/6338 34/18639 0.470588235294118 1.38392144487962 0.0789422577064102 0.29173408777787 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 14/6338 29/18639 0.482758620689655 1.41971251672996 0.0790245568200041 0.29173408777787 GO:0097472 cyclin-dependent protein kinase activity 14/6338 29/18639 0.482758620689655 1.41971251672996 0.0790245568200041 0.29173408777787 GO:0005126 cytokine receptor binding 105/6338 275/18639 0.381818181818182 1.12286353595915 0.0802535576549113 0.294878687051655 GO:0000510 H3-H4 histone complex chaperone activity 60/6338 151/18639 0.397350993377483 1.16854294186856 0.0809470905631995 0.294878687051655 GO:0140584 chromatin extrusion motor activity 60/6338 151/18639 0.397350993377483 1.16854294186856 0.0809470905631995 0.294878687051655 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 60/6338 151/18639 0.397350993377483 1.16854294186856 0.0809470905631995 0.294878687051655 GO:0140849 ATP-dependent H2AZ histone chaperone activity 60/6338 151/18639 0.397350993377483 1.16854294186856 0.0809470905631995 0.294878687051655 GO:0001618 virus receptor activity 34/6338 81/18639 0.419753086419753 1.23442375793275 0.0822198435895522 0.296684083107347 GO:0016757 glycosyltransferase activity 102/6338 267/18639 0.382022471910112 1.12346431901745 0.0825983657683072 0.296684083107347 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 6/6338 10/18639 0.6 1.76449984222152 0.0835845134491064 0.296684083107347 GO:0008641 ubiquitin-like modifier activating enzyme activity 6/6338 10/18639 0.6 1.76449984222152 0.0835845134491064 0.296684083107347 GO:0015279 store-operated calcium channel activity 6/6338 10/18639 0.6 1.76449984222152 0.0835845134491064 0.296684083107347 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 6/6338 10/18639 0.6 1.76449984222152 0.0835845134491064 0.296684083107347 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 6/6338 10/18639 0.6 1.76449984222152 0.0835845134491064 0.296684083107347 GO:0051864 histone H3K36 demethylase activity 6/6338 10/18639 0.6 1.76449984222152 0.0835845134491064 0.296684083107347 GO:0070097 delta-catenin binding 6/6338 10/18639 0.6 1.76449984222152 0.0835845134491064 0.296684083107347 GO:0051015 actin filament binding 81/6338 209/18639 0.38755980861244 1.13974870191342 0.083992037494334 0.296684083107347 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 9/6338 17/18639 0.529411764705882 1.55691162548958 0.0844590853871315 0.296684083107347 GO:0016805 dipeptidase activity 9/6338 17/18639 0.529411764705882 1.55691162548958 0.0844590853871315 0.296684083107347 GO:0048038 quinone binding 9/6338 17/18639 0.529411764705882 1.55691162548958 0.0844590853871315 0.296684083107347 GO:0070403 NAD+ binding 9/6338 17/18639 0.529411764705882 1.55691162548958 0.0844590853871315 0.296684083107347 GO:0004402 histone acetyltransferase activity 19/6338 42/18639 0.452380952380952 1.33037686516702 0.086343623932263 0.30176439125565 GO:0004520 DNA endonuclease activity 19/6338 42/18639 0.452380952380952 1.33037686516702 0.086343623932263 0.30176439125565 GO:0017018 myosin phosphatase activity 35/6338 84/18639 0.416666666666667 1.22534711265383 0.08667685253053 0.302162090973519 GO:0004407 histone deacetylase activity 11/6338 22/18639 0.5 1.4704165351846 0.089269585993028 0.307310549780999 GO:0031683 G-protein beta/gamma-subunit complex binding 11/6338 22/18639 0.5 1.4704165351846 0.089269585993028 0.307310549780999 GO:0033558 protein lysine deacetylase activity 11/6338 22/18639 0.5 1.4704165351846 0.089269585993028 0.307310549780999 GO:0034062 5'-3' RNA polymerase activity 11/6338 22/18639 0.5 1.4704165351846 0.089269585993028 0.307310549780999 GO:0097747 RNA polymerase activity 11/6338 22/18639 0.5 1.4704165351846 0.089269585993028 0.307310549780999 GO:0004722 protein serine/threonine phosphatase activity 42/6338 103/18639 0.407766990291262 1.19917465005346 0.0896346431222629 0.307797764537047 GO:0015616 DNA translocase activity 60/6338 152/18639 0.394736842105263 1.16085515935626 0.0906030777197349 0.309184018290461 GO:0008320 protein transmembrane transporter activity 13/6338 27/18639 0.481481481481481 1.4159566635111 0.0907119414592201 0.309184018290461 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 13/6338 27/18639 0.481481481481481 1.4159566635111 0.0907119414592201 0.309184018290461 GO:0008170 N-methyltransferase activity 40/6338 98/18639 0.408163265306122 1.20034002872212 0.0945314846418208 0.320670250012225 GO:0046915 transition metal ion transmembrane transporter activity 20/6338 45/18639 0.444444444444444 1.30703692016409 0.0946079353482753 0.320670250012225 GO:0016779 nucleotidyltransferase activity 54/6338 136/18639 0.397058823529412 1.16768371911718 0.0947805314124733 0.320670250012225 GO:0140272 exogenous protein binding 34/6338 82/18639 0.414634146341463 1.21936980966528 0.0959789041555999 0.32392880152515 GO:0140097 catalytic activity, acting on DNA 126/6338 336/18639 0.375 1.10281240138845 0.0962625355531896 0.324091715053159 GO:0004559 alpha-mannosidase activity 8/6338 15/18639 0.533333333333333 1.56844430419691 0.0977095736789983 0.325099532332291 GO:0005041 low-density lipoprotein particle receptor activity 8/6338 15/18639 0.533333333333333 1.56844430419691 0.0977095736789983 0.325099532332291 GO:0005523 tropomyosin binding 8/6338 15/18639 0.533333333333333 1.56844430419691 0.0977095736789983 0.325099532332291 GO:0047372 monoacylglycerol lipase activity 8/6338 15/18639 0.533333333333333 1.56844430419691 0.0977095736789983 0.325099532332291 GO:0070851 growth factor receptor binding 55/6338 139/18639 0.39568345323741 1.16363898467846 0.097744765988867 0.325099532332291 GO:0015036 disulfide oxidoreductase activity 18/6338 40/18639 0.45 1.32337488166614 0.0979961527296807 0.325099532332291 GO:1901505 carbohydrate derivative transmembrane transporter activity 23/6338 53/18639 0.433962264150943 1.27621057770739 0.0982145282862985 0.325099532332291 GO:0010485 histone H4 acetyltransferase activity 16/6338 35/18639 0.457142857142857 1.34438083216878 0.100996155361215 0.332122773573967 GO:0061631 ubiquitin conjugating enzyme activity 16/6338 35/18639 0.457142857142857 1.34438083216878 0.100996155361215 0.332122773573967 GO:0140713 histone chaperone activity 64/6338 164/18639 0.390243902439024 1.14764217380262 0.101059870826066 0.332122773573967 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 10/6338 20/18639 0.5 1.4704165351846 0.10313464612513 0.33466195051205 GO:0016408 C-acyltransferase activity 10/6338 20/18639 0.5 1.4704165351846 0.10313464612513 0.33466195051205 GO:0052745 inositol phosphate phosphatase activity 10/6338 20/18639 0.5 1.4704165351846 0.10313464612513 0.33466195051205 GO:0043995 histone H4K5 acetyltransferase activity 14/6338 30/18639 0.466666666666667 1.37238876617229 0.103290725466682 0.33466195051205 GO:0043996 histone H4K8 acetyltransferase activity 14/6338 30/18639 0.466666666666667 1.37238876617229 0.103290725466682 0.33466195051205 GO:0043997 histone H4K12 acetyltransferase activity 14/6338 30/18639 0.466666666666667 1.37238876617229 0.103290725466682 0.33466195051205 GO:0004896 cytokine receptor activity 39/6338 96/18639 0.40625 1.19471343483749 0.103981082977581 0.335676082630259 GO:0019211 phosphatase activator activity 12/6338 25/18639 0.48 1.41159987377722 0.10433504964833 0.335676082630259 GO:0120020 cholesterol transfer activity 12/6338 25/18639 0.48 1.41159987377722 0.10433504964833 0.335676082630259 GO:0019888 protein phosphatase regulator activity 43/6338 107/18639 0.401869158878505 1.18183011239136 0.106299028214225 0.341197580072234 GO:0008375 acetylglucosaminyltransferase activity 19/6338 43/18639 0.441860465116279 1.29943786830267 0.107030683498399 0.342747095761151 GO:0004222 metalloendopeptidase activity 44/6338 110/18639 0.4 1.17633322814768 0.110127591296382 0.35184615595155 GO:0042162 telomeric DNA binding 17/6338 38/18639 0.447368421052632 1.31563584727043 0.111291346383465 0.354741166597294 GO:0001786 phosphatidylserine binding 25/6338 59/18639 0.423728813559322 1.24611570778356 0.112040838180506 0.356305390703363 GO:0035673 oligopeptide transmembrane transporter activity 7/6338 13/18639 0.538461538461538 1.58352549942957 0.1134551187313 0.356684243134703 GO:0039706 co-receptor binding 7/6338 13/18639 0.538461538461538 1.58352549942957 0.1134551187313 0.356684243134703 GO:0046975 histone H3K36 methyltransferase activity 7/6338 13/18639 0.538461538461538 1.58352549942957 0.1134551187313 0.356684243134703 GO:0070123 transforming growth factor beta receptor activity, type III 7/6338 13/18639 0.538461538461538 1.58352549942957 0.1134551187313 0.356684243134703 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 7/6338 13/18639 0.538461538461538 1.58352549942957 0.1134551187313 0.356684243134703 GO:0016410 N-acyltransferase activity 38/6338 94/18639 0.404255319148936 1.18884741142585 0.114294620729855 0.358504994863349 GO:0140416 transcription regulator inhibitor activity 15/6338 33/18639 0.454545454545455 1.33674230471327 0.115205491611971 0.360540822612919 GO:0019199 transmembrane receptor protein kinase activity 32/6338 78/18639 0.41025641025641 1.20649561861301 0.117479076557695 0.363362038166079 GO:0140104 molecular carrier activity 94/6338 249/18639 0.377510040160643 1.11019401050082 0.117687436390665 0.363362038166079 GO:0003689 DNA clamp loader activity 62/6338 160/18639 0.3875 1.13957281476807 0.117857196476075 0.363362038166079 GO:0051287 NAD binding 23/6338 54/18639 0.425925925925926 1.25257704849059 0.117936790005863 0.363362038166079 GO:0036408 histone H3K14 acetyltransferase activity 13/6338 28/18639 0.464285714285714 1.36538678267142 0.11841664828101 0.363362038166079 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 13/6338 28/18639 0.464285714285714 1.36538678267142 0.11841664828101 0.363362038166079 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 9/6338 18/18639 0.5 1.4704165351846 0.119537402533939 0.363362038166079 GO:0004706 JUN kinase kinase kinase activity 9/6338 18/18639 0.5 1.4704165351846 0.119537402533939 0.363362038166079 GO:0030228 lipoprotein particle receptor activity 9/6338 18/18639 0.5 1.4704165351846 0.119537402533939 0.363362038166079 GO:0034185 apolipoprotein binding 9/6338 18/18639 0.5 1.4704165351846 0.119537402533939 0.363362038166079 GO:0035615 clathrin adaptor activity 9/6338 18/18639 0.5 1.4704165351846 0.119537402533939 0.363362038166079 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 9/6338 18/18639 0.5 1.4704165351846 0.119537402533939 0.363362038166079 GO:1990381 ubiquitin-specific protease binding 9/6338 18/18639 0.5 1.4704165351846 0.119537402533939 0.363362038166079 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 11/6338 23/18639 0.478260869565217 1.40648538148092 0.120279592174867 0.363493913080471 GO:0070577 lysine-acetylated histone binding 11/6338 23/18639 0.478260869565217 1.40648538148092 0.120279592174867 0.363493913080471 GO:0004843 cysteine-type deubiquitinase activity 43/6338 108/18639 0.398148148148148 1.17088724098033 0.120372711956932 0.363493913080471 GO:0061650 ubiquitin-like protein conjugating enzyme activity 18/6338 41/18639 0.439024390243902 1.29109744552794 0.121128185121361 0.364974859763927 GO:0004857 enzyme inhibitor activity 153/6338 416/18639 0.367788461538462 1.08160447059252 0.124188322073813 0.373378426846377 GO:0120013 lipid transfer activity 27/6338 65/18639 0.415384615384615 1.22157681384567 0.12512560032651 0.374044861337673 GO:0015932 nucleobase-containing compound transmembrane transporter activity 24/6338 57/18639 0.421052631578947 1.23824550331335 0.125224895480514 0.374044861337673 GO:0016504 peptidase activator activity 24/6338 57/18639 0.421052631578947 1.23824550331335 0.125224895480514 0.374044861337673 GO:0001046 core promoter sequence-specific DNA binding 19/6338 44/18639 0.431818181818182 1.26990518947761 0.130521598324422 0.386099663672139 GO:0005539 glycosaminoglycan binding 91/6338 242/18639 0.37603305785124 1.10585045208098 0.131396989586337 0.386099663672139 GO:0004143 ATP-dependent diacylglycerol kinase activity 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0008432 JUN kinase binding 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0032050 clathrin heavy chain binding 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0042608 T cell receptor binding 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0047676 arachidonate-CoA ligase activity 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 6/6338 11/18639 0.545454545454545 1.60409076565593 0.13234498275472 0.386099663672139 GO:0008081 phosphoric diester hydrolase activity 35/6338 87/18639 0.402298850574713 1.18309376394163 0.132864925288384 0.386797044655614 GO:0031072 heat shock protein binding 51/6338 131/18639 0.389312977099237 1.14490447777732 0.135577101952627 0.393860062001618 GO:0070006 metalloaminopeptidase activity 12/6338 26/18639 0.461538461538462 1.35730757093963 0.135995954822689 0.394245115349142 GO:0008373 sialyltransferase activity 10/6338 21/18639 0.476190476190476 1.40039670017581 0.139032252791725 0.399020384422744 GO:0010314 phosphatidylinositol-5-phosphate binding 10/6338 21/18639 0.476190476190476 1.40039670017581 0.139032252791725 0.399020384422744 GO:0140312 cargo adaptor activity 10/6338 21/18639 0.476190476190476 1.40039670017581 0.139032252791725 0.399020384422744 GO:0008142 oxysterol binding 8/6338 16/18639 0.5 1.4704165351846 0.139092073001392 0.399020384422744 GO:0022858 alanine transmembrane transporter activity 8/6338 16/18639 0.5 1.4704165351846 0.139092073001392 0.399020384422744 GO:0008374 O-acyltransferase activity 23/6338 55/18639 0.418181818181818 1.22980292033621 0.139909442968853 0.400530775401478 GO:0048487 beta-tubulin binding 18/6338 42/18639 0.428571428571429 1.26035703015823 0.147216606013185 0.420575241660074 GO:0003724 RNA helicase activity 31/6338 77/18639 0.402597402597403 1.18397175560319 0.149176241260046 0.425291271666839 GO:0010484 histone H3 acetyltransferase activity 13/6338 29/18639 0.448275862068966 1.31830447982068 0.150422722593077 0.427958861592287 GO:0042625 ATPase-coupled ion transmembrane transporter activity 11/6338 24/18639 0.458333333333333 1.34788182391922 0.156496928863232 0.441590719353834 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 11/6338 24/18639 0.458333333333333 1.34788182391922 0.156496928863232 0.441590719353834 GO:0046961 proton-transporting ATPase activity, rotational mechanism 11/6338 24/18639 0.458333333333333 1.34788182391922 0.156496928863232 0.441590719353834 GO:0140033 acetylation-dependent protein binding 11/6338 24/18639 0.458333333333333 1.34788182391922 0.156496928863232 0.441590719353834 GO:0043021 ribonucleoprotein complex binding 67/6338 177/18639 0.378531073446328 1.11319669895331 0.157095504035848 0.442373229156162 GO:0004386 helicase activity 59/6338 155/18639 0.380645161290323 1.1194138783986 0.161862886802016 0.451509393778687 GO:0004065 arylsulfatase activity 7/6338 14/18639 0.5 1.4704165351846 0.162635191949331 0.451509393778687 GO:0005347 ATP transmembrane transporter activity 7/6338 14/18639 0.5 1.4704165351846 0.162635191949331 0.451509393778687 GO:0008331 high voltage-gated calcium channel activity 7/6338 14/18639 0.5 1.4704165351846 0.162635191949331 0.451509393778687 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 7/6338 14/18639 0.5 1.4704165351846 0.162635191949331 0.451509393778687 GO:0098821 BMP receptor activity 7/6338 14/18639 0.5 1.4704165351846 0.162635191949331 0.451509393778687 GO:0098847 sequence-specific single stranded DNA binding 7/6338 14/18639 0.5 1.4704165351846 0.162635191949331 0.451509393778687 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 34/6338 86/18639 0.395348837209302 1.16265493479713 0.165524593373326 0.458606368360302 GO:0030331 nuclear estrogen receptor binding 17/6338 40/18639 0.425 1.24985405490691 0.16606017273488 0.459166381236808 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 47/6338 122/18639 0.385245901639344 1.13294388776518 0.167904712092068 0.463336249600758 GO:0016278 lysine N-methyltransferase activity 28/6338 70/18639 0.4 1.17633322814768 0.174542302789517 0.480689501882331 GO:0016741 transferase activity, transferring one-carbon groups 80/6338 215/18639 0.372093023255814 1.09426346804435 0.177067071836629 0.486669377083909 GO:0008093 cytoskeletal anchor activity 10/6338 22/18639 0.454545454545455 1.33674230471327 0.180501141790639 0.494135332496441 GO:0030021 extracellular matrix structural constituent conferring compression resistance 10/6338 22/18639 0.454545454545455 1.33674230471327 0.180501141790639 0.494135332496441 GO:0160215 deacylase activity 26/6338 65/18639 0.4 1.17633322814768 0.185676862030354 0.50729571233293 GO:0017022 myosin binding 30/6338 76/18639 0.394736842105263 1.16085515935626 0.186727497358993 0.507305126429876 GO:0005109 frizzled binding 16/6338 38/18639 0.421052631578947 1.23824550331335 0.18732423686323 0.507305126429876 GO:0004029 aldehyde dehydrogenase (NAD+) activity 8/6338 17/18639 0.470588235294118 1.38392144487962 0.187654728658513 0.507305126429876 GO:0030169 low-density lipoprotein particle binding 8/6338 17/18639 0.470588235294118 1.38392144487962 0.187654728658513 0.507305126429876 GO:0070402 NADPH binding 8/6338 17/18639 0.470588235294118 1.38392144487962 0.187654728658513 0.507305126429876 GO:0043022 ribosome binding 43/6338 112/18639 0.383928571428571 1.12906983951675 0.187890787566621 0.507305126429876 GO:0005165 neurotrophin receptor binding 6/6338 12/18639 0.5 1.4704165351846 0.19135244496573 0.511635566442349 GO:0016423 tRNA (guanine) methyltransferase activity 6/6338 12/18639 0.5 1.4704165351846 0.19135244496573 0.511635566442349 GO:0035251 UDP-glucosyltransferase activity 6/6338 12/18639 0.5 1.4704165351846 0.19135244496573 0.511635566442349 GO:0035259 nuclear glucocorticoid receptor binding 6/6338 12/18639 0.5 1.4704165351846 0.19135244496573 0.511635566442349 GO:0043047 single-stranded telomeric DNA binding 6/6338 12/18639 0.5 1.4704165351846 0.19135244496573 0.511635566442349 GO:0030145 manganese ion binding 27/6338 68/18639 0.397058823529412 1.16768371911718 0.192300975953638 0.511755136658987 GO:0140223 general transcription initiation factor activity 27/6338 68/18639 0.397058823529412 1.16768371911718 0.192300975953638 0.511755136658987 GO:0008186 ATP-dependent activity, acting on RNA 31/6338 79/18639 0.392405063291139 1.1539977871069 0.192512099338675 0.511755136658987 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 17/6338 41/18639 0.414634146341463 1.21936980966528 0.197886997294457 0.524019990912436 GO:0016877 ligase activity, forming carbon-sulfur bonds 17/6338 41/18639 0.414634146341463 1.21936980966528 0.197886997294457 0.524019990912436 GO:0019956 chemokine binding 14/6338 33/18639 0.424242424242424 1.24762615106572 0.19943520923492 0.527106109628571 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 21/6338 52/18639 0.403846153846154 1.18764412457218 0.203043951540969 0.535615941133935 GO:0008201 heparin binding 64/6338 172/18639 0.372093023255814 1.09426346804435 0.207971133632739 0.546454853232543 GO:0016505 peptidase activator activity involved in apoptotic process 9/6338 20/18639 0.45 1.32337488166614 0.208740198112068 0.546454853232543 GO:0031418 L-ascorbic acid binding 9/6338 20/18639 0.45 1.32337488166614 0.208740198112068 0.546454853232543 GO:0043024 ribosomal small subunit binding 9/6338 20/18639 0.45 1.32337488166614 0.208740198112068 0.546454853232543 GO:0004033 aldo-keto reductase (NADPH) activity 15/6338 36/18639 0.416666666666667 1.22534711265383 0.211311326325048 0.551469054509723 GO:0016798 hydrolase activity, acting on glycosyl bonds 49/6338 130/18639 0.376923076923077 1.1084678496007 0.211456543777149 0.551469054509723 GO:0097718 disordered domain specific binding 12/6338 28/18639 0.428571428571429 1.26035703015823 0.212578053437804 0.553345897133945 GO:0043495 protein-membrane adaptor activity 19/6338 47/18639 0.404255319148936 1.18884741142585 0.216958765294465 0.555244392203125 GO:0016279 protein-lysine N-methyltransferase activity 27/6338 69/18639 0.391304347826087 1.15076076666621 0.218148616716869 0.555244392203125 GO:0042809 nuclear vitamin D receptor binding 7/6338 15/18639 0.466666666666667 1.37238876617229 0.219445107935872 0.555244392203125 GO:0050780 dopamine receptor binding 7/6338 15/18639 0.466666666666667 1.37238876617229 0.219445107935872 0.555244392203125 GO:0051371 muscle alpha-actinin binding 7/6338 15/18639 0.466666666666667 1.37238876617229 0.219445107935872 0.555244392203125 GO:0003774 cytoskeletal motor activity 57/6338 153/18639 0.372549019607843 1.09560447719637 0.220573724820232 0.555244392203125 GO:0004022 alcohol dehydrogenase (NAD+) activity 10/6338 23/18639 0.434782608695652 1.27862307407357 0.226825410725849 0.555244392203125 GO:0016849 phosphorus-oxygen lyase activity 10/6338 23/18639 0.434782608695652 1.27862307407357 0.226825410725849 0.555244392203125 GO:0043274 phospholipase binding 10/6338 23/18639 0.434782608695652 1.27862307407357 0.226825410725849 0.555244392203125 GO:0044013 histone H2B acetyltransferase activity 10/6338 23/18639 0.434782608695652 1.27862307407357 0.226825410725849 0.555244392203125 GO:0140103 catalytic activity, acting on a glycoprotein 10/6338 23/18639 0.434782608695652 1.27862307407357 0.226825410725849 0.555244392203125 GO:0000182 rDNA binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0004445 inositol-polyphosphate 5-phosphatase activity 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0005031 tumor necrosis factor receptor activity 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0005381 iron ion transmembrane transporter activity 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0008140 cAMP response element binding protein binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0016303 1-phosphatidylinositol-3-kinase activity 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0016783 sulfurtransferase activity 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0043208 glycosphingolipid binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0045322 unmethylated CpG binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0050815 phosphoserine residue binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0051880 G-quadruplex DNA binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0098505 G-rich strand telomeric DNA binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0140999 histone H3K4 trimethyltransferase activity 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:1905394 retromer complex binding 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 5/6338 10/18639 0.5 1.4704165351846 0.2270171334861 0.555244392203125 GO:0005246 calcium channel regulator activity 21/6338 53/18639 0.39622641509434 1.16523574486327 0.233751867449426 0.57070269765578 GO:0015035 protein-disulfide reductase activity 14/6338 34/18639 0.411764705882353 1.21093126426967 0.238355803360017 0.580913170312819 GO:0042054 histone methyltransferase activity 26/6338 67/18639 0.388059701492537 1.14121880342685 0.239271952193541 0.582115685813616 GO:0051539 4 iron, 4 sulfur cluster binding 18/6338 45/18639 0.4 1.17633322814768 0.241722016590785 0.584972963628067 GO:0000900 mRNA regulatory element binding translation repressor activity 8/6338 18/18639 0.444444444444444 1.30703692016409 0.242148589558173 0.584972963628067 GO:0030247 polysaccharide binding 11/6338 26/18639 0.423076923076923 1.24419860669466 0.24257048818564 0.584972963628067 GO:0030507 spectrin binding 11/6338 26/18639 0.423076923076923 1.24419860669466 0.24257048818564 0.584972963628067 GO:0034237 protein kinase A regulatory subunit binding 11/6338 26/18639 0.423076923076923 1.24419860669466 0.24257048818564 0.584972963628067 GO:0016758 hexosyltransferase activity 72/6338 197/18639 0.365482233502538 1.07482223891666 0.246252377245269 0.592813852214573 GO:0004527 exonuclease activity 32/6338 84/18639 0.380952380952381 1.12031736014065 0.246920156710543 0.593384041519053 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 19/6338 48/18639 0.395833333333333 1.16407975702114 0.250462892824543 0.600849134876996 GO:0004521 RNA endonuclease activity 28/6338 73/18639 0.383561643835616 1.12799076671695 0.251515749061416 0.602325541665339 GO:0051861 glycolipid binding 12/6338 29/18639 0.413793103448276 1.21689644291139 0.256452404622318 0.61071034029787 GO:0008035 high-density lipoprotein particle binding 6/6338 13/18639 0.461538461538462 1.35730757093963 0.258121581738098 0.61071034029787 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 6/6338 13/18639 0.461538461538462 1.35730757093963 0.258121581738098 0.61071034029787 GO:0046974 histone H3K9 methyltransferase activity 6/6338 13/18639 0.461538461538462 1.35730757093963 0.258121581738098 0.61071034029787 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 6/6338 13/18639 0.461538461538462 1.35730757093963 0.258121581738098 0.61071034029787 GO:0061459 L-arginine transmembrane transporter activity 6/6338 13/18639 0.461538461538462 1.35730757093963 0.258121581738098 0.61071034029787 GO:0140852 histone ubiquitin ligase activity 6/6338 13/18639 0.461538461538462 1.35730757093963 0.258121581738098 0.61071034029787 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 16/6338 40/18639 0.4 1.17633322814768 0.259693059476981 0.61337451612316 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 9/6338 21/18639 0.428571428571429 1.26035703015823 0.261021157102325 0.614403646717781 GO:0036122 BMP binding 9/6338 21/18639 0.428571428571429 1.26035703015823 0.261021157102325 0.614403646717781 GO:0071813 lipoprotein particle binding 13/6338 32/18639 0.40625 1.19471343483749 0.268823789835379 0.630613898813147 GO:0071814 protein-lipid complex binding 13/6338 32/18639 0.40625 1.19471343483749 0.268823789835379 0.630613898813147 GO:0030276 clathrin binding 18/6338 46/18639 0.391304347826087 1.15076076666621 0.277773313611651 0.650499749733408 GO:0000062 fatty-acyl-CoA binding 7/6338 16/18639 0.4375 1.28661446828653 0.281941912884912 0.652494141247939 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 7/6338 16/18639 0.4375 1.28661446828653 0.281941912884912 0.652494141247939 GO:0016722 oxidoreductase activity, acting on metal ions 7/6338 16/18639 0.4375 1.28661446828653 0.281941912884912 0.652494141247939 GO:0034450 ubiquitin-ubiquitin ligase activity 7/6338 16/18639 0.4375 1.28661446828653 0.281941912884912 0.652494141247939 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 7/6338 16/18639 0.4375 1.28661446828653 0.281941912884912 0.652494141247939 GO:0097027 ubiquitin-protein transferase activator activity 7/6338 16/18639 0.4375 1.28661446828653 0.281941912884912 0.652494141247939 GO:0140328 floppase activity 7/6338 16/18639 0.4375 1.28661446828653 0.281941912884912 0.652494141247939 GO:0005385 zinc ion transmembrane transporter activity 11/6338 27/18639 0.407407407407407 1.19811717681708 0.290934272522761 0.671049402451998 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 11/6338 27/18639 0.407407407407407 1.19811717681708 0.290934272522761 0.671049402451998 GO:0008235 metalloexopeptidase activity 25/6338 66/18639 0.378787878787879 1.11395192059439 0.292894941095652 0.674442029914236 GO:0008574 plus-end-directed microtubule motor activity 8/6338 19/18639 0.421052631578947 1.23824550331335 0.301007418532883 0.684941277682304 GO:0046527 glucosyltransferase activity 8/6338 19/18639 0.421052631578947 1.23824550331335 0.301007418532883 0.684941277682304 GO:0097001 ceramide binding 8/6338 19/18639 0.421052631578947 1.23824550331335 0.301007418532883 0.684941277682304 GO:0008106 alcohol dehydrogenase (NADP+) activity 12/6338 30/18639 0.4 1.17633322814768 0.303110782342081 0.684941277682304 GO:0070566 adenylyltransferase activity 12/6338 30/18639 0.4 1.17633322814768 0.303110782342081 0.684941277682304 GO:0001851 complement component C3b binding 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0002162 dystroglycan binding 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0004016 adenylate cyclase activity 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0008526 phosphatidylinositol transfer activity 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0019203 carbohydrate phosphatase activity 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0019864 IgG binding 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0045294 alpha-catenin binding 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0050998 nitric-oxide synthase binding 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0140537 transcription regulator activator activity 5/6338 11/18639 0.454545454545455 1.33674230471327 0.305910592428916 0.684941277682304 GO:0030020 extracellular matrix structural constituent conferring tensile strength 17/6338 44/18639 0.386363636363636 1.13623095900628 0.30770826655323 0.687847862084087 GO:0016887 ATP hydrolysis activity 147/6338 417/18639 0.352517985611511 1.03669654998627 0.310049951577225 0.689078172687621 GO:0061749 forked DNA-dependent helicase activity 18/6338 47/18639 0.382978723404255 1.12627649503501 0.315520274636112 0.689078172687621 GO:1990518 single-stranded 3'-5' DNA helicase activity 18/6338 47/18639 0.382978723404255 1.12627649503501 0.315520274636112 0.689078172687621 GO:0016881 acid-amino acid ligase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0032931 histone H3K56 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0043992 histone H3K9 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0043993 histone H3K18 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0043994 histone H3K23 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0043999 histone H2AK5 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0044012 histone H2AK9 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0044014 histone H2BK5 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0044015 histone H2BK12 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0044016 histone H3K4 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0044017 histone H3K27 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0044018 histone H3K36 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0046972 histone H4K16 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0140908 histone H3K122 acetyltransferase activity 9/6338 22/18639 0.409090909090909 1.20306807424195 0.316765783087338 0.689078172687621 GO:0004540 RNA nuclease activity 44/6338 121/18639 0.363636363636364 1.06939384377062 0.322303954289992 0.700019787156654 GO:0004864 protein phosphatase inhibitor activity 20/6338 53/18639 0.377358490566038 1.10974832844121 0.329524586447985 0.701489188636052 GO:0016251 RNA polymerase II general transcription initiation factor activity 20/6338 53/18639 0.377358490566038 1.10974832844121 0.329524586447985 0.701489188636052 GO:0017046 peptide hormone binding 20/6338 53/18639 0.377358490566038 1.10974832844121 0.329524586447985 0.701489188636052 GO:0008174 mRNA methyltransferase activity 6/6338 14/18639 0.428571428571429 1.26035703015823 0.329736374079673 0.701489188636052 GO:0008494 translation activator activity 6/6338 14/18639 0.428571428571429 1.26035703015823 0.329736374079673 0.701489188636052 GO:0008559 ABC-type xenobiotic transporter activity 6/6338 14/18639 0.428571428571429 1.26035703015823 0.329736374079673 0.701489188636052 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 6/6338 14/18639 0.428571428571429 1.26035703015823 0.329736374079673 0.701489188636052 GO:0031404 chloride ion binding 6/6338 14/18639 0.428571428571429 1.26035703015823 0.329736374079673 0.701489188636052 GO:0032036 myosin heavy chain binding 6/6338 14/18639 0.428571428571429 1.26035703015823 0.329736374079673 0.701489188636052 GO:0044548 S100 protein binding 6/6338 14/18639 0.428571428571429 1.26035703015823 0.329736374079673 0.701489188636052 GO:0070742 C2H2 zinc finger domain binding 6/6338 14/18639 0.428571428571429 1.26035703015823 0.329736374079673 0.701489188636052 GO:0003707 nuclear steroid receptor activity 10/6338 25/18639 0.4 1.17633322814768 0.330112559358142 0.701489188636052 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 10/6338 25/18639 0.4 1.17633322814768 0.330112559358142 0.701489188636052 GO:0017025 TBP-class protein binding 10/6338 25/18639 0.4 1.17633322814768 0.330112559358142 0.701489188636052 GO:0044325 transmembrane transporter binding 49/6338 136/18639 0.360294117647059 1.05956485623596 0.338209032852814 0.717586807763213 GO:0008307 structural constituent of muscle 16/6338 42/18639 0.380952380952381 1.12031736014065 0.34042190906338 0.718958541074041 GO:0019894 kinesin binding 16/6338 42/18639 0.380952380952381 1.12031736014065 0.34042190906338 0.718958541074041 GO:0035198 miRNA binding 16/6338 42/18639 0.380952380952381 1.12031736014065 0.34042190906338 0.718958541074041 GO:0004549 tRNA-specific ribonuclease activity 7/6338 17/18639 0.411764705882353 1.21093126426967 0.34794294184339 0.727037072713731 GO:0004659 prenyltransferase activity 7/6338 17/18639 0.411764705882353 1.21093126426967 0.34794294184339 0.727037072713731 GO:0005092 GDP-dissociation inhibitor activity 7/6338 17/18639 0.411764705882353 1.21093126426967 0.34794294184339 0.727037072713731 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 7/6338 17/18639 0.411764705882353 1.21093126426967 0.34794294184339 0.727037072713731 GO:0015278 intracellularly gated calcium channel activity 7/6338 17/18639 0.411764705882353 1.21093126426967 0.34794294184339 0.727037072713731 GO:0017110 nucleoside diphosphate phosphatase activity 7/6338 17/18639 0.411764705882353 1.21093126426967 0.34794294184339 0.727037072713731 GO:1901567 fatty acid derivative binding 7/6338 17/18639 0.411764705882353 1.21093126426967 0.34794294184339 0.727037072713731 GO:1901681 sulfur compound binding 97/6338 275/18639 0.352727272727273 1.0373120284575 0.348675823992231 0.727464560056518 GO:0070273 phosphatidylinositol-4-phosphate binding 12/6338 31/18639 0.387096774193548 1.13838699498163 0.351737919765557 0.732742988679533 GO:0009378 four-way junction helicase activity 18/6338 48/18639 0.375 1.10281240138845 0.354554703723053 0.734168160942322 GO:0036121 double-stranded DNA helicase activity 18/6338 48/18639 0.375 1.10281240138845 0.354554703723053 0.734168160942322 GO:0038187 pattern recognition receptor activity 18/6338 48/18639 0.375 1.10281240138845 0.354554703723053 0.734168160942322 GO:0043138 3'-5' DNA helicase activity 18/6338 48/18639 0.375 1.10281240138845 0.354554703723053 0.734168160942322 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 13/6338 34/18639 0.382352941176471 1.12443617396469 0.360708144856801 0.745788461663386 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 8/6338 20/18639 0.4 1.17633322814768 0.362518898813426 0.747288209080969 GO:0030742 GTP-dependent protein binding 8/6338 20/18639 0.4 1.17633322814768 0.362518898813426 0.747288209080969 GO:0003684 damaged DNA binding 27/6338 74/18639 0.364864864864865 1.07300666081038 0.366901456858144 0.755191787882906 GO:0003887 DNA-directed DNA polymerase activity 9/6338 23/18639 0.391304347826087 1.15076076666621 0.374584593891152 0.767563966946602 GO:0008171 O-methyltransferase activity 9/6338 23/18639 0.391304347826087 1.15076076666621 0.374584593891152 0.767563966946602 GO:0017134 fibroblast growth factor binding 9/6338 23/18639 0.391304347826087 1.15076076666621 0.374584593891152 0.767563966946602 GO:0004714 transmembrane receptor protein tyrosine kinase activity 22/6338 60/18639 0.366666666666667 1.07830545913537 0.377347356072574 0.772076239690839 GO:0005507 copper ion binding 23/6338 63/18639 0.365079365079365 1.07363747013479 0.38219986945289 0.773789864535479 GO:0005245 voltage-gated calcium channel activity 16/6338 43/18639 0.372093023255814 1.09426346804435 0.382696199769408 0.773789864535479 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 16/6338 43/18639 0.372093023255814 1.09426346804435 0.382696199769408 0.773789864535479 GO:0004435 phosphatidylinositol phospholipase C activity 10/6338 26/18639 0.384615384615385 1.13108964244969 0.384826353840956 0.773789864535479 GO:0004529 DNA exonuclease activity 10/6338 26/18639 0.384615384615385 1.13108964244969 0.384826353840956 0.773789864535479 GO:0000340 RNA 7-methylguanosine cap binding 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0004875 complement receptor activity 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0005078 MAP-kinase scaffold activity 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0005247 voltage-gated chloride channel activity 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0016273 arginine N-methyltransferase activity 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0016274 protein-arginine N-methyltransferase activity 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0035197 siRNA binding 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0045295 gamma-catenin binding 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0070410 co-SMAD binding 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0070679 inositol 1,4,5 trisphosphate binding 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 5/6338 12/18639 0.416666666666667 1.22534711265383 0.387737840616907 0.773789864535479 GO:0004180 carboxypeptidase activity 17/6338 46/18639 0.369565217391304 1.08682961296253 0.388804676738972 0.774796005599949 GO:0052689 carboxylic ester hydrolase activity 33/6338 92/18639 0.358695652173913 1.05486403611069 0.390132643957738 0.776318859436135 GO:0008276 protein methyltransferase activity 34/6338 95/18639 0.357894736842105 1.05250867781635 0.393486136109723 0.778898473561095 GO:0003785 actin monomer binding 11/6338 29/18639 0.379310344827586 1.11548840600211 0.393691603194279 0.778898473561095 GO:0004629 phospholipase C activity 11/6338 29/18639 0.379310344827586 1.11548840600211 0.393691603194279 0.778898473561095 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 11/6338 29/18639 0.379310344827586 1.11548840600211 0.393691603194279 0.778898473561095 GO:0016763 pentosyltransferase activity 18/6338 49/18639 0.36734693877551 1.08030602584991 0.394448427893509 0.779276162423761 GO:0031369 translation initiation factor binding 12/6338 32/18639 0.375 1.10281240138845 0.401486397723663 0.783207855328237 GO:0043425 bHLH transcription factor binding 12/6338 32/18639 0.375 1.10281240138845 0.401486397723663 0.783207855328237 GO:0051059 NF-kappaB binding 12/6338 32/18639 0.375 1.10281240138845 0.401486397723663 0.783207855328237 GO:0000774 adenyl-nucleotide exchange factor activity 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0004467 long-chain fatty acid-CoA ligase activity 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0005402 carbohydrate:monoatomic cation symporter activity 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0033130 acetylcholine receptor binding 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0045504 dynein heavy chain binding 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0050700 CARD domain binding 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0140776 protein-containing complex destabilizing activity 6/6338 15/18639 0.4 1.17633322814768 0.403263884842208 0.783207855328237 GO:0008408 3'-5' exonuclease activity 21/6338 58/18639 0.362068965517241 1.06478438754747 0.409160180304646 0.793540237013377 GO:0017075 syntaxin-1 binding 7/6338 18/18639 0.388888888888889 1.14365730514358 0.415266620570348 0.804250543636244 GO:0016853 isomerase activity 63/6338 180/18639 0.35 1.02929157462922 0.415955953906627 0.804454141193014 GO:0031490 chromatin DNA binding 45/6338 128/18639 0.3515625 1.03388662630167 0.42388832368265 0.813857580502389 GO:0005123 death receptor binding 8/6338 21/18639 0.380952380952381 1.12031736014065 0.424979047558719 0.813857580502389 GO:0009931 calcium-dependent protein serine/threonine kinase activity 8/6338 21/18639 0.380952380952381 1.12031736014065 0.424979047558719 0.813857580502389 GO:0009975 cyclase activity 8/6338 21/18639 0.380952380952381 1.12031736014065 0.424979047558719 0.813857580502389 GO:0015174 basic amino acid transmembrane transporter activity 8/6338 21/18639 0.380952380952381 1.12031736014065 0.424979047558719 0.813857580502389 GO:0072542 protein phosphatase activator activity 8/6338 21/18639 0.380952380952381 1.12031736014065 0.424979047558719 0.813857580502389 GO:0016782 transferase activity, transferring sulphur-containing groups 25/6338 70/18639 0.357142857142857 1.05029752513186 0.42502080629324 0.813857580502389 GO:0043014 alpha-tubulin binding 16/6338 44/18639 0.363636363636364 1.06939384377062 0.425546447321511 0.813857580502389 GO:0051087 protein-folding chaperone binding 47/6338 134/18639 0.350746268656716 1.03148622617427 0.428451865457949 0.818277695888483 GO:0004806 triacylglycerol lipase activity 9/6338 24/18639 0.375 1.10281240138845 0.433099325849212 0.821203101129686 GO:0015295 solute:proton symporter activity 9/6338 24/18639 0.375 1.10281240138845 0.433099325849212 0.821203101129686 GO:0043998 histone H2A acetyltransferase activity 9/6338 24/18639 0.375 1.10281240138845 0.433099325849212 0.821203101129686 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 9/6338 24/18639 0.375 1.10281240138845 0.433099325849212 0.821203101129686 GO:0070840 dynein complex binding 9/6338 24/18639 0.375 1.10281240138845 0.433099325849212 0.821203101129686 GO:0008094 ATP-dependent activity, acting on DNA 73/6338 210/18639 0.347619047619048 1.02228959112834 0.433561840610952 0.821203101129686 GO:0032813 tumor necrosis factor receptor superfamily binding 18/6338 50/18639 0.36 1.05869990533291 0.434767994500224 0.822350358794571 GO:0005319 lipid transporter activity 62/6338 178/18639 0.348314606741573 1.02433511439826 0.435361954655949 0.822350358794571 GO:0016405 CoA-ligase activity 10/6338 27/18639 0.37037037037037 1.08919743347007 0.440056989910483 0.828944562389514 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 10/6338 27/18639 0.37037037037037 1.08919743347007 0.440056989910483 0.828944562389514 GO:0019212 phosphatase inhibitor activity 20/6338 56/18639 0.357142857142857 1.05029752513186 0.442765734519192 0.832907672722579 GO:0051721 protein phosphatase 2A binding 11/6338 30/18639 0.366666666666667 1.07830545913537 0.446133131056078 0.83809730076974 GO:0015179 L-amino acid transmembrane transporter activity 22/6338 62/18639 0.354838709677419 1.04352141206649 0.449822824628394 0.839357606407094 GO:0019239 deaminase activity 12/6338 33/18639 0.363636363636364 1.06939384377062 0.451520700865369 0.839357606407094 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0004382 GDP phosphatase activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0015643 toxic substance binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0015924 mannosyl-oligosaccharide mannosidase activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0016175 superoxide-generating NAD(P)H oxidase activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0030957 Tat protein binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0031434 mitogen-activated protein kinase kinase binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0031957 very long-chain fatty acid-CoA ligase activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0031996 thioesterase binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0035256 G protein-coupled glutamate receptor binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0035374 chondroitin sulfate binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0050308 sugar-phosphatase activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0070739 protein-glutamic acid ligase activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0070740 tubulin-glutamic acid ligase activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0071723 lipopeptide binding 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:1990757 ubiquitin ligase activator activity 4/6338 10/18639 0.4 1.17633322814768 0.459051589855808 0.839357606407094 GO:0048306 calcium-dependent protein binding 28/6338 80/18639 0.35 1.02929157462922 0.467069253520995 0.839357606407094 GO:0141110 transporter inhibitor activity 16/6338 45/18639 0.355555555555556 1.04562953613127 0.468456847560926 0.839357606407094 GO:0051082 unfolded protein binding 42/6338 121/18639 0.347107438016529 1.02078503269014 0.468731502137823 0.839357606407094 GO:0005035 death receptor activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0008253 5'-nucleotidase activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0008417 fucosyltransferase activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0009982 pseudouridine synthase activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0019104 DNA N-glycosylase activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0019855 calcium channel inhibitor activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0043560 insulin receptor substrate binding 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0070700 BMP receptor binding 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0071714 icosanoid transmembrane transporter activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0089720 caspase binding 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0097157 pre-mRNA intronic binding 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0140333 glycerophospholipid flippase activity 5/6338 13/18639 0.384615384615385 1.13108964244969 0.468748002416162 0.839357606407094 GO:0030544 Hsp70 protein binding 18/6338 51/18639 0.352941176470588 1.03794108365972 0.475088415562029 0.841502673503 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0005149 interleukin-1 receptor binding 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0005324 long-chain fatty acid transmembrane transporter activity 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0008296 3'-5'-DNA exonuclease activity 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0015562 efflux transmembrane transporter activity 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0017070 U6 snRNA binding 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0022841 potassium ion leak channel activity 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0030275 LRR domain binding 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0140327 flippase activity 6/6338 16/18639 0.375 1.10281240138845 0.476057068016585 0.841502673503 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 19/6338 54/18639 0.351851851851852 1.03473756179657 0.478087935870121 0.84320310109525 GO:0042626 ATPase-coupled transmembrane transporter activity 34/6338 98/18639 0.346938775510204 1.0202890244138 0.480484829198367 0.84320310109525 GO:0003756 protein disulfide isomerase activity 7/6338 19/18639 0.368421052631579 1.08346481539918 0.481917821758869 0.84320310109525 GO:0015245 fatty acid transmembrane transporter activity 7/6338 19/18639 0.368421052631579 1.08346481539918 0.481917821758869 0.84320310109525 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 7/6338 19/18639 0.368421052631579 1.08346481539918 0.481917821758869 0.84320310109525 GO:0022840 leak channel activity 7/6338 19/18639 0.368421052631579 1.08346481539918 0.481917821758869 0.84320310109525 GO:0022842 narrow pore channel activity 7/6338 19/18639 0.368421052631579 1.08346481539918 0.481917821758869 0.84320310109525 GO:0120227 acyl-CoA binding 7/6338 19/18639 0.368421052631579 1.08346481539918 0.481917821758869 0.84320310109525 GO:0061133 endopeptidase activator activity 8/6338 22/18639 0.363636363636364 1.06939384377062 0.486815198685222 0.850691026128872 GO:0015645 fatty acid ligase activity 9/6338 25/18639 0.36 1.05869990533291 0.491029382000439 0.855882859512157 GO:0120515 fatty acid-CoA ligase activity 9/6338 25/18639 0.36 1.05869990533291 0.491029382000439 0.855882859512157 GO:0050698 proteoglycan sulfotransferase activity 10/6338 28/18639 0.357142857142857 1.05029752513186 0.494735675716258 0.858109950826681 GO:0051393 alpha-actinin binding 10/6338 28/18639 0.357142857142857 1.05029752513186 0.494735675716258 0.858109950826681 GO:0051959 dynein light intermediate chain binding 10/6338 28/18639 0.357142857142857 1.05029752513186 0.494735675716258 0.858109950826681 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 42/6338 122/18639 0.344262295081967 1.01241794225825 0.494799782829619 0.858109950826681 GO:0005164 tumor necrosis factor receptor binding 11/6338 31/18639 0.354838709677419 1.04352141206649 0.498050497265864 0.861577304943586 GO:0016878 acid-thiol ligase activity 11/6338 31/18639 0.354838709677419 1.04352141206649 0.498050497265864 0.861577304943586 GO:0045296 cadherin binding 114/6338 334/18639 0.341317365269461 1.00375739527572 0.501011623252867 0.864602118221751 GO:0051427 hormone receptor binding 12/6338 34/18639 0.352941176470588 1.03794108365972 0.501054822324588 0.864602118221751 GO:0042805 actinin binding 13/6338 37/18639 0.351351351351351 1.03326567337296 0.503807100216184 0.868263300372573 GO:0071949 FAD binding 14/6338 40/18639 0.35 1.02929157462922 0.506350819166161 0.871556347489754 GO:0060590 ATPase regulator activity 17/6338 49/18639 0.346938775510204 1.0202890244138 0.513027884185053 0.881946812138349 GO:0061980 regulatory RNA binding 20/6338 58/18639 0.344827586206897 1.01408036909283 0.518675069889463 0.890543106281535 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 23/6338 67/18639 0.343283582089552 1.00953971072376 0.523609563428598 0.897895851607944 GO:0004550 nucleoside diphosphate kinase activity 6/6338 17/18639 0.352941176470588 1.03794108365972 0.545937500474691 0.901960162212889 GO:0038191 neuropilin binding 6/6338 17/18639 0.352941176470588 1.03794108365972 0.545937500474691 0.901960162212889 GO:0045125 bioactive lipid receptor activity 6/6338 17/18639 0.352941176470588 1.03794108365972 0.545937500474691 0.901960162212889 GO:0070492 oligosaccharide binding 6/6338 17/18639 0.352941176470588 1.03794108365972 0.545937500474691 0.901960162212889 GO:1990226 histone methyltransferase binding 6/6338 17/18639 0.352941176470588 1.03794108365972 0.545937500474691 0.901960162212889 GO:0008474 palmitoyl-(protein) hydrolase activity 5/6338 14/18639 0.357142857142857 1.05029752513186 0.545976684825323 0.901960162212889 GO:0016530 metallochaperone activity 5/6338 14/18639 0.357142857142857 1.05029752513186 0.545976684825323 0.901960162212889 GO:0019992 diacylglycerol binding 5/6338 14/18639 0.357142857142857 1.05029752513186 0.545976684825323 0.901960162212889 GO:0030983 mismatched DNA binding 5/6338 14/18639 0.357142857142857 1.05029752513186 0.545976684825323 0.901960162212889 GO:0098599 palmitoyl hydrolase activity 5/6338 14/18639 0.357142857142857 1.05029752513186 0.545976684825323 0.901960162212889 GO:0000339 RNA cap binding 7/6338 20/18639 0.35 1.02929157462922 0.546209549498722 0.901960162212889 GO:0042288 MHC class I protein binding 7/6338 20/18639 0.35 1.02929157462922 0.546209549498722 0.901960162212889 GO:0140939 histone H4 methyltransferase activity 7/6338 20/18639 0.35 1.02929157462922 0.546209549498722 0.901960162212889 GO:0000099 sulfur amino acid transmembrane transporter activity 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0004954 prostanoid receptor activity 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0008172 S-methyltransferase activity 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0010854 adenylate cyclase regulator activity 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0015173 aromatic amino acid transmembrane transporter activity 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0015217 ADP transmembrane transporter activity 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0016176 superoxide-generating NADPH oxidase activator activity 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0032404 mismatch repair complex binding 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0043522 leucine zipper domain binding 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0048407 platelet-derived growth factor binding 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0070697 activin receptor binding 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0070990 snRNP binding 4/6338 11/18639 0.363636363636364 1.06939384377062 0.546560731242603 0.901960162212889 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11/6338 32/18639 0.34375 1.01091136793941 0.54863169226416 0.901960162212889 GO:0016229 steroid dehydrogenase activity 12/6338 35/18639 0.342857142857143 1.00828562412658 0.549381714888586 0.901960162212889 GO:0034061 DNA polymerase activity 12/6338 35/18639 0.342857142857143 1.00828562412658 0.549381714888586 0.901960162212889 GO:0042887 amide transmembrane transporter activity 13/6338 38/18639 0.342105263157895 1.0060744714421 0.550154861241721 0.901960162212889 GO:0043531 ADP binding 13/6338 38/18639 0.342105263157895 1.0060744714421 0.550154861241721 0.901960162212889 GO:0017080 sodium channel regulator activity 14/6338 41/18639 0.341463414634146 1.00418690207729 0.550942779860967 0.901960162212889 GO:0016248 channel inhibitor activity 15/6338 44/18639 0.340909090909091 1.00255672853496 0.551739534851469 0.901960162212889 GO:0019205 nucleobase-containing compound kinase activity 15/6338 44/18639 0.340909090909091 1.00255672853496 0.551739534851469 0.901960162212889 GO:0140359 ABC-type transporter activity 16/6338 47/18639 0.340425531914894 1.00113466225335 0.552540844421862 0.901960162212889 GO:0008194 UDP-glycosyltransferase activity 49/6338 145/18639 0.337931034482759 0.993798761710972 0.552756602944549 0.901960162212889 GO:0005006 epidermal growth factor receptor activity 17/6338 50/18639 0.34 0.999883243925529 0.553343584931782 0.901960162212889 GO:0005017 platelet-derived growth factor receptor activity 17/6338 50/18639 0.34 0.999883243925529 0.553343584931782 0.901960162212889 GO:0005019 platelet-derived growth factor beta-receptor activity 17/6338 50/18639 0.34 0.999883243925529 0.553343584931782 0.901960162212889 GO:0005003 ephrin receptor activity 18/6338 53/18639 0.339622641509434 0.998773495597087 0.55414545913733 0.901960162212889 GO:0005005 transmembrane-ephrin receptor activity 18/6338 53/18639 0.339622641509434 0.998773495597087 0.55414545913733 0.901960162212889 GO:0038064 collagen receptor activity 18/6338 53/18639 0.339622641509434 0.998773495597087 0.55414545913733 0.901960162212889 GO:0000049 tRNA binding 27/6338 80/18639 0.3375 0.992531161249606 0.56114831428942 0.912280081200155 GO:0030165 PDZ domain binding 28/6338 83/18639 0.337349397590361 0.992088264702863 0.56189459596374 0.912416106889234 GO:0050660 flavin adenine dinucleotide binding 29/6338 86/18639 0.337209302325581 0.991676267915196 0.562634053772579 0.912540744457999 GO:0001664 G protein-coupled receptor binding 100/6338 297/18639 0.336700336700337 0.990179484972795 0.570629529679935 0.924419838081494 GO:0061134 peptidase regulator activity 76/6338 226/18639 0.336283185840708 0.988952713929466 0.572758717470559 0.926778794309001 GO:0017069 snRNA binding 18/6338 54/18639 0.333333333333333 0.980277690123067 0.592174220770935 0.953364405020673 GO:0050661 NADP binding 18/6338 54/18639 0.333333333333333 0.980277690123067 0.592174220770935 0.953364405020673 GO:0005010 insulin-like growth factor receptor activity 17/6338 51/18639 0.333333333333333 0.980277690123067 0.592471169616658 0.953364405020673 GO:0005021 vascular endothelial growth factor receptor activity 17/6338 51/18639 0.333333333333333 0.980277690123067 0.592471169616658 0.953364405020673 GO:0016879 ligase activity, forming carbon-nitrogen bonds 16/6338 48/18639 0.333333333333333 0.980277690123067 0.592867230223493 0.953364405020673 GO:0042056 chemoattractant activity 14/6338 42/18639 0.333333333333333 0.980277690123067 0.594035337333143 0.953364405020673 GO:0051879 Hsp90 protein binding 14/6338 42/18639 0.333333333333333 0.980277690123067 0.594035337333143 0.953364405020673 GO:0055106 ubiquitin-protein transferase regulator activity 12/6338 36/18639 0.333333333333333 0.980277690123067 0.595893924497467 0.954791076535003 GO:0030296 protein tyrosine kinase activator activity 11/6338 33/18639 0.333333333333333 0.980277690123067 0.597187187963555 0.954791076535003 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 44/6338 132/18639 0.333333333333333 0.980277690123067 0.597217541683296 0.954791076535003 GO:0033612 receptor serine/threonine kinase binding 10/6338 30/18639 0.333333333333333 0.980277690123067 0.59880858424791 0.954791076535003 GO:0035925 mRNA 3'-UTR AU-rich region binding 10/6338 30/18639 0.333333333333333 0.980277690123067 0.59880858424791 0.954791076535003 GO:0015085 calcium ion transmembrane transporter activity 49/6338 147/18639 0.333333333333333 0.980277690123067 0.59908459704157 0.954791076535003 GO:0001671 ATPase activator activity 9/6338 27/18639 0.333333333333333 0.980277690123067 0.600853276877948 0.955398339793227 GO:0005104 fibroblast growth factor receptor binding 9/6338 27/18639 0.333333333333333 0.980277690123067 0.600853276877948 0.955398339793227 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 8/6338 24/18639 0.333333333333333 0.980277690123067 0.603457618938484 0.957799368592466 GO:0035613 RNA stem-loop binding 7/6338 21/18639 0.333333333333333 0.980277690123067 0.606824800468724 0.957799368592466 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 7/6338 21/18639 0.333333333333333 0.980277690123067 0.606824800468724 0.957799368592466 GO:0061891 calcium ion sensor activity 7/6338 21/18639 0.333333333333333 0.980277690123067 0.606824800468724 0.957799368592466 GO:0008308 voltage-gated monoatomic anion channel activity 6/6338 18/18639 0.333333333333333 0.980277690123067 0.611272940426862 0.957799368592466 GO:0008525 phosphatidylcholine transporter activity 6/6338 18/18639 0.333333333333333 0.980277690123067 0.611272940426862 0.957799368592466 GO:0015172 acidic amino acid transmembrane transporter activity 6/6338 18/18639 0.333333333333333 0.980277690123067 0.611272940426862 0.957799368592466 GO:0016854 racemase and epimerase activity 6/6338 18/18639 0.333333333333333 0.980277690123067 0.611272940426862 0.957799368592466 GO:0031690 adrenergic receptor binding 6/6338 18/18639 0.333333333333333 0.980277690123067 0.611272940426862 0.957799368592466 GO:0032393 MHC class I receptor activity 6/6338 18/18639 0.333333333333333 0.980277690123067 0.611272940426862 0.957799368592466 GO:0050811 GABA receptor binding 6/6338 18/18639 0.333333333333333 0.980277690123067 0.611272940426862 0.957799368592466 GO:0008242 omega peptidase activity 5/6338 15/18639 0.333333333333333 0.980277690123067 0.617333084816881 0.957799368592466 GO:0008252 nucleotidase activity 5/6338 15/18639 0.333333333333333 0.980277690123067 0.617333084816881 0.957799368592466 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 5/6338 15/18639 0.333333333333333 0.980277690123067 0.617333084816881 0.957799368592466 GO:0017081 chloride channel regulator activity 5/6338 15/18639 0.333333333333333 0.980277690123067 0.617333084816881 0.957799368592466 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 43/6338 130/18639 0.330769230769231 0.972737092506736 0.620870949742497 0.957799368592466 GO:0072341 modified amino acid binding 30/6338 91/18639 0.32967032967033 0.969505407814022 0.621474211268648 0.957799368592466 GO:0051536 iron-sulfur cluster binding 25/6338 76/18639 0.328947368421053 0.967379299463553 0.623216608705027 0.957799368592466 GO:0003995 acyl-CoA dehydrogenase activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0004000 adenosine deaminase activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0004526 ribonuclease P activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0005049 nuclear export signal receptor activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0005095 GTPase inhibitor activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0008179 adenylate cyclase binding 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0015132 prostaglandin transmembrane transporter activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0016208 AMP binding 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0017166 vinculin binding 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0031543 peptidyl-proline dioxygenase activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0036009 protein-glutamine N-methyltransferase activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0097677 STAT family protein binding 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/6338 12/18639 0.333333333333333 0.980277690123067 0.62597217655545 0.957799368592466 GO:0005004 GPI-linked ephrin receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0005008 hepatocyte growth factor receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0005009 insulin receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0005011 macrophage colony-stimulating factor receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0005018 platelet-derived growth factor alpha-receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0005020 stem cell factor receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0008288 boss receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0036332 placental growth factor receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0038062 protein tyrosine kinase collagen receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0060175 brain-derived neurotrophic factor receptor activity 16/6338 49/18639 0.326530612244898 0.960272022977698 0.631577216181525 0.957799368592466 GO:0008200 ion channel inhibitor activity 14/6338 43/18639 0.325581395348837 0.95748053453881 0.635222455444429 0.96226768002968 GO:0008376 acetylgalactosaminyltransferase activity 11/6338 34/18639 0.323529411764706 0.951445993354742 0.643163536747409 0.970442523550722 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 11/6338 34/18639 0.323529411764706 0.951445993354742 0.643163536747409 0.970442523550722 GO:0090482 vitamin transmembrane transporter activity 11/6338 34/18639 0.323529411764706 0.951445993354742 0.643163536747409 0.970442523550722 GO:0141108 transporter regulator activity 56/6338 170/18639 0.329411764705882 0.968745011415737 0.64343792592724 0.970442523550722 GO:0016866 intramolecular transferase activity 9/6338 28/18639 0.321428571428571 0.945267772618672 0.65111950900717 0.979881490604232 GO:0046625 sphingolipid binding 9/6338 28/18639 0.321428571428571 0.945267772618672 0.65111950900717 0.979881490604232 GO:0051540 metal cluster binding 25/6338 77/18639 0.324675324675325 0.954815931938052 0.653419203357867 0.982268824261772 GO:0048029 monosaccharide binding 24/6338 74/18639 0.324324324324324 0.95378369849812 0.654508933200029 0.982834025099716 GO:0015296 monoatomic anion:monoatomic cation symporter activity 8/6338 25/18639 0.32 0.941066582518145 0.656365024556387 0.983476211984924 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 8/6338 25/18639 0.32 0.941066582518145 0.656365024556387 0.983476211984924 GO:0015377 chloride:monoatomic cation symporter activity 7/6338 22/18639 0.318181818181818 0.935719613299291 0.662829281301024 0.991005342401206 GO:0140784 metal ion sensor activity 7/6338 22/18639 0.318181818181818 0.935719613299291 0.662829281301024 0.991005342401206 GO:0170055 lipid transmembrane transporter activity 18/6338 56/18639 0.321428571428571 0.945267772618672 0.663786832386851 0.991360594573421 GO:0015297 antiporter activity 44/6338 135/18639 0.325925925925926 0.958493741453666 0.666613394417163 0.99450340640567 GO:0005007 fibroblast growth factor receptor activity 16/6338 50/18639 0.32 0.941066582518145 0.668393042651992 0.996079242133975 GO:0050145 nucleoside monophosphate kinase activity 6/6338 19/18639 0.315789473684211 0.928684127485011 0.670975302889014 0.996746736992317 GO:0070003 threonine-type peptidase activity 6/6338 19/18639 0.315789473684211 0.928684127485011 0.670975302889014 0.996746736992317 GO:0004175 endopeptidase activity 134/6338 405/18639 0.330864197530864 0.973016373899933 0.67101250921705 0.996746736992317 GO:0030246 carbohydrate binding 92/6338 280/18639 0.328571428571429 0.966273723121309 0.679565453512995 1 GO:0015385 sodium:proton antiporter activity 5/6338 16/18639 0.3125 0.919010334490376 0.681549456089742 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/6338 16/18639 0.3125 0.919010334490376 0.681549456089742 1 GO:0055102 lipase inhibitor activity 5/6338 16/18639 0.3125 0.919010334490376 0.681549456089742 1 GO:0005506 iron ion binding 50/6338 154/18639 0.324675324675325 0.954815931938052 0.685276444827723 1 GO:0005154 epidermal growth factor receptor binding 11/6338 35/18639 0.314285714285714 0.924261822116035 0.686146871766036 1 GO:0008378 galactosyltransferase activity 10/6338 32/18639 0.3125 0.919010334490376 0.691405413578738 1 GO:0042910 xenobiotic transmembrane transporter activity 10/6338 32/18639 0.3125 0.919010334490376 0.691405413578738 1 GO:1901682 sulfur compound transmembrane transporter activity 20/6338 63/18639 0.317460317460317 0.933597800117207 0.691841416115747 1 GO:0003697 single-stranded DNA binding 39/6338 121/18639 0.322314049586777 0.947871816069412 0.691944858843018 1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 19/6338 60/18639 0.316666666666667 0.931263805616914 0.694272466377035 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 19/6338 60/18639 0.316666666666667 0.931263805616914 0.694272466377035 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/6338 13/18639 0.307692307692308 0.904871713959754 0.695849587284022 1 GO:0031432 titin binding 4/6338 13/18639 0.307692307692308 0.904871713959754 0.695849587284022 1 GO:0032396 inhibitory MHC class I receptor activity 4/6338 13/18639 0.307692307692308 0.904871713959754 0.695849587284022 1 GO:0045159 myosin II binding 4/6338 13/18639 0.307692307692308 0.904871713959754 0.695849587284022 1 GO:1901338 catecholamine binding 4/6338 13/18639 0.307692307692308 0.904871713959754 0.695849587284022 1 GO:0035250 UDP-galactosyltransferase activity 9/6338 29/18639 0.310344827586207 0.912672332183545 0.697560743127612 1 GO:0099604 ligand-gated calcium channel activity 9/6338 29/18639 0.310344827586207 0.912672332183545 0.697560743127612 1 GO:0005030 neurotrophin receptor activity 16/6338 51/18639 0.313725490196078 0.922614296586416 0.703100184611002 1 GO:0120014 phospholipid transfer activity 8/6338 26/18639 0.307692307692308 0.904871713959754 0.704858584556799 1 GO:0005262 calcium channel activity 42/6338 131/18639 0.320610687022901 0.942862511110736 0.711128270545273 1 GO:0004602 glutathione peroxidase activity 7/6338 23/18639 0.304347826086957 0.895036151851496 0.713648301326821 1 GO:0005212 structural constituent of eye lens 7/6338 23/18639 0.304347826086957 0.895036151851496 0.713648301326821 1 GO:0031681 G-protein beta-subunit binding 7/6338 23/18639 0.304347826086957 0.895036151851496 0.713648301326821 1 GO:0140102 catalytic activity, acting on a rRNA 7/6338 23/18639 0.304347826086957 0.895036151851496 0.713648301326821 1 GO:0001094 TFIID-class transcription factor complex binding 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0004935 adrenergic receptor activity 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0004955 prostaglandin receptor activity 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0008190 eukaryotic initiation factor 4E binding 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0032356 oxidized DNA binding 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0033204 ribonuclease P RNA binding 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0043121 neurotrophin binding 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0047429 nucleoside triphosphate diphosphatase activity 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0140940 histone H2A methyltransferase activity 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0141109 transporter activator activity 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:1990259 histone H2AQ104 methyltransferase activity 3/6338 10/18639 0.3 0.882249921110761 0.716385101283526 1 GO:0000217 DNA secondary structure binding 12/6338 39/18639 0.307692307692308 0.904871713959754 0.720160705691667 1 GO:0016247 channel regulator activity 54/6338 168/18639 0.321428571428571 0.945267772618672 0.721584214435189 1 GO:0001614 purinergic nucleotide receptor activity 6/6338 20/18639 0.3 0.882249921110761 0.724446340056281 1 GO:0010851 cyclase regulator activity 6/6338 20/18639 0.3 0.882249921110761 0.724446340056281 1 GO:0016502 nucleotide receptor activity 6/6338 20/18639 0.3 0.882249921110761 0.724446340056281 1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 19/6338 61/18639 0.311475409836066 0.915997185852702 0.724856249292753 1 GO:0017116 single-stranded DNA helicase activity 18/6338 58/18639 0.310344827586207 0.912672332183545 0.728109319029014 1 GO:0061135 endopeptidase regulator activity 59/6338 184/18639 0.320652173913043 0.942984517129255 0.73599352353286 1 GO:0016018 cyclosporin A binding 5/6338 17/18639 0.294117647058824 0.864950903049765 0.738054437596013 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 5/6338 17/18639 0.294117647058824 0.864950903049765 0.738054437596013 1 GO:0031489 myosin V binding 5/6338 17/18639 0.294117647058824 0.864950903049765 0.738054437596013 1 GO:0036041 long-chain fatty acid binding 5/6338 17/18639 0.294117647058824 0.864950903049765 0.738054437596013 1 GO:0045236 CXCR chemokine receptor binding 5/6338 17/18639 0.294117647058824 0.864950903049765 0.738054437596013 1 GO:0003777 microtubule motor activity 21/6338 68/18639 0.308823529411765 0.908198448202253 0.746851341790706 1 GO:0005548 phospholipid transporter activity 21/6338 68/18639 0.308823529411765 0.908198448202253 0.746851341790706 1 GO:0004683 calcium/calmodulin-dependent protein kinase activity 8/6338 27/18639 0.296296296296296 0.87135794677606 0.748650293053157 1 GO:0008266 poly(U) RNA binding 8/6338 27/18639 0.296296296296296 0.87135794677606 0.748650293053157 1 GO:0004532 RNA exonuclease activity 12/6338 40/18639 0.3 0.882249921110761 0.755597068558598 1 GO:0015144 carbohydrate transmembrane transporter activity 12/6338 40/18639 0.3 0.882249921110761 0.755597068558598 1 GO:0015386 potassium:proton antiporter activity 4/6338 14/18639 0.285714285714286 0.840238020105486 0.755798748267502 1 GO:0019763 immunoglobulin receptor activity 4/6338 14/18639 0.285714285714286 0.840238020105486 0.755798748267502 1 GO:0070888 E-box binding 18/6338 59/18639 0.305084745762712 0.897203309604163 0.757207794217823 1 GO:0004622 lysophospholipase activity 7/6338 24/18639 0.291666666666667 0.857742978857684 0.759020935251431 1 GO:0005315 phosphate transmembrane transporter activity 7/6338 24/18639 0.291666666666667 0.857742978857684 0.759020935251431 1 GO:0030215 semaphorin receptor binding 7/6338 24/18639 0.291666666666667 0.857742978857684 0.759020935251431 1 GO:0030552 cAMP binding 7/6338 24/18639 0.291666666666667 0.857742978857684 0.759020935251431 1 GO:0050699 WW domain binding 7/6338 24/18639 0.291666666666667 0.857742978857684 0.759020935251431 1 GO:0070300 phosphatidic acid binding 7/6338 24/18639 0.291666666666667 0.857742978857684 0.759020935251431 1 GO:0004866 endopeptidase inhibitor activity 51/6338 161/18639 0.316770186335404 0.93156823968217 0.75958810539737 1 GO:0030551 cyclic nucleotide binding 11/6338 37/18639 0.297297297297297 0.874301723623276 0.762142332123012 1 GO:0008146 sulfotransferase activity 16/6338 53/18639 0.30188679245283 0.887798662752967 0.765635479976611 1 GO:0001846 opsonin binding 6/6338 21/18639 0.285714285714286 0.840238020105486 0.771494955891303 1 GO:0019200 carbohydrate kinase activity 6/6338 21/18639 0.285714285714286 0.840238020105486 0.771494955891303 1 GO:0008327 methyl-CpG binding 9/6338 31/18639 0.290322580645161 0.85379024623622 0.777967198814443 1 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0005225 volume-sensitive anion channel activity 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0008046 axon guidance receptor activity 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0008199 ferric iron binding 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0008503 benzodiazepine receptor activity 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0019215 intermediate filament binding 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0034056 estrogen response element binding 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0050786 RAGE receptor binding 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 3/6338 11/18639 0.272727272727273 0.802045382827964 0.780069240048873 1 GO:0000400 four-way junction DNA binding 5/6338 18/18639 0.277777777777778 0.816898075102556 0.786816551891841 1 GO:0003746 translation elongation factor activity 5/6338 18/18639 0.277777777777778 0.816898075102556 0.786816551891841 1 GO:0015280 ligand-gated sodium channel activity 5/6338 18/18639 0.277777777777778 0.816898075102556 0.786816551891841 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 5/6338 18/18639 0.277777777777778 0.816898075102556 0.786816551891841 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 5/6338 18/18639 0.277777777777778 0.816898075102556 0.786816551891841 1 GO:0098641 cadherin binding involved in cell-cell adhesion 5/6338 18/18639 0.277777777777778 0.816898075102556 0.786816551891841 1 GO:0045499 chemorepellent activity 8/6338 28/18639 0.285714285714286 0.840238020105486 0.787662606671552 1 GO:0051119 sugar transmembrane transporter activity 8/6338 28/18639 0.285714285714286 0.840238020105486 0.787662606671552 1 GO:0001530 lipopolysaccharide binding 12/6338 41/18639 0.292682926829268 0.860731630351961 0.78785022873709 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 12/6338 41/18639 0.292682926829268 0.860731630351961 0.78785022873709 1 GO:0042287 MHC protein binding 12/6338 41/18639 0.292682926829268 0.860731630351961 0.78785022873709 1 GO:0099106 ion channel regulator activity 50/6338 160/18639 0.3125 0.919010334490376 0.793711068029849 1 GO:0000146 microfilament motor activity 11/6338 38/18639 0.289473684210526 0.851293783527927 0.794953140965392 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 11/6338 38/18639 0.289473684210526 0.851293783527927 0.794953140965392 1 GO:0005048 signal sequence binding 15/6338 51/18639 0.294117647058824 0.864950903049765 0.798482158562931 1 GO:0005537 D-mannose binding 7/6338 25/18639 0.28 0.823433259703376 0.798942678299504 1 GO:0008139 nuclear localization sequence binding 7/6338 25/18639 0.28 0.823433259703376 0.798942678299504 1 GO:0047617 fatty acyl-CoA hydrolase activity 7/6338 25/18639 0.28 0.823433259703376 0.798942678299504 1 GO:0003727 single-stranded RNA binding 27/6338 89/18639 0.303370786516854 0.892162841572679 0.799695026297883 1 GO:0000175 3'-5'-RNA exonuclease activity 10/6338 35/18639 0.285714285714286 0.840238020105486 0.802896076196055 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 4/6338 15/18639 0.266666666666667 0.784222152098454 0.806149898613182 1 GO:0004953 icosanoid receptor activity 4/6338 15/18639 0.266666666666667 0.784222152098454 0.806149898613182 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 4/6338 15/18639 0.266666666666667 0.784222152098454 0.806149898613182 1 GO:0015929 hexosaminidase activity 4/6338 15/18639 0.266666666666667 0.784222152098454 0.806149898613182 1 GO:0031386 protein tag activity 4/6338 15/18639 0.266666666666667 0.784222152098454 0.806149898613182 1 GO:0048531 beta-1,3-galactosyltransferase activity 4/6338 15/18639 0.266666666666667 0.784222152098454 0.806149898613182 1 GO:0141047 molecular tag activity 4/6338 15/18639 0.266666666666667 0.784222152098454 0.806149898613182 1 GO:0016298 lipase activity 40/6338 130/18639 0.307692307692308 0.904871713959754 0.808335880192671 1 GO:0008009 chemokine activity 13/6338 45/18639 0.288888888888889 0.849573998106658 0.810218039114461 1 GO:0140142 nucleocytoplasmic carrier activity 9/6338 32/18639 0.28125 0.827109301041338 0.811839201732763 1 GO:0008649 rRNA methyltransferase activity 6/6338 22/18639 0.272727272727273 0.802045382827964 0.812244583862658 1 GO:0140517 protein-RNA adaptor activity 6/6338 22/18639 0.272727272727273 0.802045382827964 0.812244583862658 1 GO:0004181 metallocarboxypeptidase activity 8/6338 29/18639 0.275862068965517 0.811264295274262 0.821987126116863 1 GO:0106222 lncRNA binding 8/6338 29/18639 0.275862068965517 0.811264295274262 0.821987126116863 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 5/6338 19/18639 0.263157894736842 0.773903439570843 0.828188426535708 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/6338 19/18639 0.263157894736842 0.773903439570843 0.828188426535708 1 GO:0016918 retinal binding 5/6338 19/18639 0.263157894736842 0.773903439570843 0.828188426535708 1 GO:0022821 solute:potassium antiporter activity 5/6338 19/18639 0.263157894736842 0.773903439570843 0.828188426535708 1 GO:0030506 ankyrin binding 5/6338 19/18639 0.263157894736842 0.773903439570843 0.828188426535708 1 GO:0046624 sphingolipid transporter activity 5/6338 19/18639 0.263157894736842 0.773903439570843 0.828188426535708 1 GO:0015101 organic cation transmembrane transporter activity 24/6338 81/18639 0.296296296296296 0.87135794677606 0.82874607400042 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 56/6338 181/18639 0.30939226519337 0.909871005197101 0.829642052115083 1 GO:0003720 telomerase activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0004126 cytidine deaminase activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0010853 cyclase activator activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0015166 polyol transmembrane transporter activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0015368 calcium:monoatomic cation antiporter activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0016801 hydrolase activity, acting on ether bonds 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0016803 ether hydrolase activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0042301 phosphate ion binding 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0140900 chloride:bicarbonate antiporter activity 3/6338 12/18639 0.25 0.7352082675923 0.831434927880014 1 GO:0004190 aspartic-type endopeptidase activity 10/6338 36/18639 0.277777777777778 0.816898075102556 0.832526040669843 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 10/6338 36/18639 0.277777777777778 0.816898075102556 0.832526040669843 1 GO:0045505 dynein intermediate chain binding 10/6338 36/18639 0.277777777777778 0.816898075102556 0.832526040669843 1 GO:0001637 G protein-coupled chemoattractant receptor activity 7/6338 26/18639 0.269230769230769 0.791762749714785 0.833605239152079 1 GO:0004950 chemokine receptor activity 7/6338 26/18639 0.269230769230769 0.791762749714785 0.833605239152079 1 GO:0008143 poly(A) binding 7/6338 26/18639 0.269230769230769 0.791762749714785 0.833605239152079 1 GO:0015145 monosaccharide transmembrane transporter activity 7/6338 26/18639 0.269230769230769 0.791762749714785 0.833605239152079 1 GO:0016289 acyl-CoA hydrolase activity 7/6338 26/18639 0.269230769230769 0.791762749714785 0.833605239152079 1 GO:0019865 immunoglobulin binding 7/6338 26/18639 0.269230769230769 0.791762749714785 0.833605239152079 1 GO:0051139 metal cation:proton antiporter activity 7/6338 26/18639 0.269230769230769 0.791762749714785 0.833605239152079 1 GO:0030414 peptidase inhibitor activity 52/6338 169/18639 0.307692307692308 0.904871713959754 0.834699052039547 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 27/6338 91/18639 0.296703296703297 0.87255486703262 0.83781336233512 1 GO:0005283 amino acid:sodium symporter activity 6/6338 23/18639 0.260869565217391 0.767173844444139 0.847043271816482 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/6338 16/18639 0.25 0.7352082675923 0.847683379454329 1 GO:0019841 retinol binding 4/6338 16/18639 0.25 0.7352082675923 0.847683379454329 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 4/6338 16/18639 0.25 0.7352082675923 0.847683379454329 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 11/6338 40/18639 0.275 0.808729094351531 0.850409226952746 1 GO:0008187 poly-pyrimidine tract binding 8/6338 30/18639 0.266666666666667 0.784222152098454 0.851843136729105 1 GO:0031210 phosphatidylcholine binding 8/6338 30/18639 0.266666666666667 0.784222152098454 0.851843136729105 1 GO:0070001 aspartic-type peptidase activity 10/6338 37/18639 0.27027027027027 0.794819748748433 0.858594080872373 1 GO:0016209 antioxidant activity 25/6338 86/18639 0.290697674418605 0.854893334409652 0.860986008964655 1 GO:0070279 vitamin B6 binding 16/6338 57/18639 0.280701754385965 0.825497002208899 0.862265716221809 1 GO:0061608 nuclear import signal receptor activity 5/6338 20/18639 0.25 0.7352082675923 0.86276912202885 1 GO:0004364 glutathione transferase activity 7/6338 27/18639 0.259259259259259 0.762438203429052 0.863339470286702 1 GO:0035255 ionotropic glutamate receptor binding 7/6338 27/18639 0.259259259259259 0.762438203429052 0.863339470286702 1 GO:0008083 growth factor activity 49/6338 162/18639 0.302469135802469 0.889511237333894 0.864159888716649 1 GO:0016790 thiolester hydrolase activity 12/6338 44/18639 0.272727272727273 0.802045382827964 0.865992651006568 1 GO:0030547 signaling receptor inhibitor activity 12/6338 44/18639 0.272727272727273 0.802045382827964 0.865992651006568 1 GO:0016500 protein-hormone receptor activity 19/6338 67/18639 0.283582089552239 0.833967587119624 0.866550861798269 1 GO:0003964 RNA-directed DNA polymerase activity 3/6338 13/18639 0.230769230769231 0.678653785469816 0.872110530058812 1 GO:0004465 lipoprotein lipase activity 3/6338 13/18639 0.230769230769231 0.678653785469816 0.872110530058812 1 GO:0004535 poly(A)-specific ribonuclease activity 3/6338 13/18639 0.230769230769231 0.678653785469816 0.872110530058812 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 3/6338 13/18639 0.230769230769231 0.678653785469816 0.872110530058812 1 GO:0030955 potassium ion binding 3/6338 13/18639 0.230769230769231 0.678653785469816 0.872110530058812 1 GO:0071837 HMG box domain binding 3/6338 13/18639 0.230769230769231 0.678653785469816 0.872110530058812 1 GO:0003678 DNA helicase activity 21/6338 74/18639 0.283783783783784 0.834560736185854 0.875229987801821 1 GO:0005540 hyaluronic acid binding 6/6338 24/18639 0.25 0.7352082675923 0.876384050671499 1 GO:0015149 hexose transmembrane transporter activity 6/6338 24/18639 0.25 0.7352082675923 0.876384050671499 1 GO:0019957 C-C chemokine binding 6/6338 24/18639 0.25 0.7352082675923 0.876384050671499 1 GO:0055056 D-glucose transmembrane transporter activity 6/6338 24/18639 0.25 0.7352082675923 0.876384050671499 1 GO:0140612 DNA damage sensor activity 6/6338 24/18639 0.25 0.7352082675923 0.876384050671499 1 GO:0005452 solute:inorganic anion antiporter activity 8/6338 31/18639 0.258064516129032 0.758924663321084 0.877539115134205 1 GO:0072349 modified amino acid transmembrane transporter activity 8/6338 31/18639 0.258064516129032 0.758924663321084 0.877539115134205 1 GO:0140299 molecular sensor activity 20/6338 71/18639 0.28169014084507 0.828403681794141 0.879221359240615 1 GO:0140303 intramembrane lipid transporter activity 12/6338 45/18639 0.266666666666667 0.784222152098454 0.886274328058244 1 GO:0019843 rRNA binding 18/6338 65/18639 0.276923076923077 0.814384542563779 0.887802123339264 1 GO:0005242 inward rectifier potassium channel activity 7/6338 28/18639 0.25 0.7352082675923 0.888565091491751 1 GO:0051537 2 iron, 2 sulfur cluster binding 7/6338 28/18639 0.25 0.7352082675923 0.888565091491751 1 GO:0044183 protein folding chaperone 21/6338 75/18639 0.28 0.823433259703376 0.890573876103197 1 GO:0015125 bile acid transmembrane transporter activity 5/6338 21/18639 0.238095238095238 0.700198350087905 0.891292298946834 1 GO:0051428 peptide hormone receptor binding 5/6338 21/18639 0.238095238095238 0.700198350087905 0.891292298946834 1 GO:1904047 S-adenosyl-L-methionine binding 5/6338 21/18639 0.238095238095238 0.700198350087905 0.891292298946834 1 GO:0035254 glutamate receptor binding 13/6338 49/18639 0.26530612244898 0.78022101866938 0.89766324114002 1 GO:0070717 poly-purine tract binding 8/6338 32/18639 0.25 0.7352082675923 0.899439086268019 1 GO:0001848 complement binding 6/6338 25/18639 0.24 0.705799936888608 0.900839220894235 1 GO:0008483 transaminase activity 6/6338 25/18639 0.24 0.705799936888608 0.900839220894235 1 GO:0015662 P-type ion transporter activity 6/6338 25/18639 0.24 0.705799936888608 0.900839220894235 1 GO:0140358 P-type transmembrane transporter activity 6/6338 25/18639 0.24 0.705799936888608 0.900839220894235 1 GO:0030170 pyridoxal phosphate binding 15/6338 56/18639 0.267857142857143 0.787723143848893 0.902373146037125 1 GO:0005345 purine nucleobase transmembrane transporter activity 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0015203 polyamine transmembrane transporter activity 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0016868 intramolecular phosphotransferase activity 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0019911 structural constituent of myelin sheath 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0031419 cobalamin binding 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0032052 bile acid binding 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0043295 glutathione binding 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0097177 mitochondrial ribosome binding 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0140135 mechanosensitive monoatomic cation channel activity 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:1990763 arrestin family protein binding 2/6338 10/18639 0.2 0.58816661407384 0.903628128597233 1 GO:0005313 L-glutamate transmembrane transporter activity 3/6338 14/18639 0.214285714285714 0.630178515079115 0.903831925092805 1 GO:0008195 phosphatidate phosphatase activity 3/6338 14/18639 0.214285714285714 0.630178515079115 0.903831925092805 1 GO:0015926 glucosidase activity 3/6338 14/18639 0.214285714285714 0.630178515079115 0.903831925092805 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/6338 14/18639 0.214285714285714 0.630178515079115 0.903831925092805 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/6338 14/18639 0.214285714285714 0.630178515079115 0.903831925092805 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/6338 14/18639 0.214285714285714 0.630178515079115 0.903831925092805 1 GO:1901474 azole transmembrane transporter activity 3/6338 14/18639 0.214285714285714 0.630178515079115 0.903831925092805 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 12/6338 46/18639 0.260869565217391 0.767173844444139 0.903985137100294 1 GO:0015171 amino acid transmembrane transporter activity 29/6338 102/18639 0.284313725490196 0.83611920628144 0.90403911868315 1 GO:0098631 cell adhesion mediator activity 21/6338 76/18639 0.276315789473684 0.812598611549385 0.904377469570534 1 GO:0005200 structural constituent of cytoskeleton 32/6338 112/18639 0.285714285714286 0.840238020105486 0.90763966783622 1 GO:0070628 proteasome binding 4/6338 18/18639 0.222222222222222 0.653518460082045 0.908443592899648 1 GO:0004620 phospholipase activity 31/6338 109/18639 0.284403669724771 0.836383717260966 0.910004667260705 1 GO:0033691 sialic acid binding 5/6338 22/18639 0.227272727272727 0.668371152356637 0.914541626912769 1 GO:0070034 telomerase RNA binding 5/6338 22/18639 0.227272727272727 0.668371152356637 0.914541626912769 1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8/6338 33/18639 0.242424242424242 0.712929229180413 0.917934728251175 1 GO:0016597 amino acid binding 13/6338 51/18639 0.254901960784314 0.749624115976463 0.92705022376642 1 GO:0016830 carbon-carbon lyase activity 13/6338 51/18639 0.254901960784314 0.749624115976463 0.92705022376642 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 7/6338 30/18639 0.233333333333333 0.686194383086147 0.927372509994071 1 GO:0016769 transferase activity, transferring nitrogenous groups 7/6338 30/18639 0.233333333333333 0.686194383086147 0.927372509994071 1 GO:0048019 receptor antagonist activity 7/6338 30/18639 0.233333333333333 0.686194383086147 0.927372509994071 1 GO:0004129 cytochrome-c oxidase activity 3/6338 15/18639 0.2 0.58816661407384 0.928252431712711 1 GO:0010181 FMN binding 3/6338 15/18639 0.2 0.58816661407384 0.928252431712711 1 GO:0016846 carbon-sulfur lyase activity 3/6338 15/18639 0.2 0.58816661407384 0.928252431712711 1 GO:0030553 cGMP binding 3/6338 15/18639 0.2 0.58816661407384 0.928252431712711 1 GO:0034483 heparan sulfate sulfotransferase activity 3/6338 15/18639 0.2 0.58816661407384 0.928252431712711 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/6338 15/18639 0.2 0.58816661407384 0.928252431712711 1 GO:0140161 monocarboxylate:sodium symporter activity 3/6338 15/18639 0.2 0.58816661407384 0.928252431712711 1 GO:0008301 DNA binding, bending 4/6338 19/18639 0.210526315789474 0.619122751656674 0.929844970596699 1 GO:0008381 mechanosensitive monoatomic ion channel activity 4/6338 19/18639 0.210526315789474 0.619122751656674 0.929844970596699 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 4/6338 19/18639 0.210526315789474 0.619122751656674 0.929844970596699 1 GO:0031420 alkali metal ion binding 4/6338 19/18639 0.210526315789474 0.619122751656674 0.929844970596699 1 GO:0042577 lipid phosphatase activity 4/6338 19/18639 0.210526315789474 0.619122751656674 0.929844970596699 1 GO:0042834 peptidoglycan binding 4/6338 19/18639 0.210526315789474 0.619122751656674 0.929844970596699 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:0008271 secondary active sulfate transmembrane transporter activity 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:0015205 nucleobase transmembrane transporter activity 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:0019206 nucleoside kinase activity 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:0034511 U3 snoRNA binding 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:0035252 UDP-xylosyltransferase activity 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:0042285 xylosyltransferase activity 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:1900750 oligopeptide binding 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:1990948 ubiquitin ligase inhibitor activity 2/6338 11/18639 0.181818181818182 0.534696921885309 0.931085659385757 1 GO:0140828 metal cation:monoatomic cation antiporter activity 10/6338 41/18639 0.24390243902439 0.717276358626635 0.932177257560135 1 GO:0016493 C-C chemokine receptor activity 5/6338 23/18639 0.217391304347826 0.639311537036783 0.93329116999507 1 GO:0016831 carboxy-lyase activity 8/6338 34/18639 0.235294117647059 0.691960722439812 0.933423388924143 1 GO:0098632 cell-cell adhesion mediator activity 14/6338 55/18639 0.254545454545455 0.748575690639433 0.9339415067149 1 GO:0033293 monocarboxylic acid binding 21/6338 79/18639 0.265822784810127 0.781740436427256 0.937519292048092 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 15/6338 59/18639 0.254237288135593 0.747669424670136 0.940117257145908 1 GO:0005343 organic acid:sodium symporter activity 8/6338 35/18639 0.228571428571429 0.672190416084389 0.946291679072875 1 GO:0001972 retinoic acid binding 4/6338 20/18639 0.2 0.58816661407384 0.94661393273866 1 GO:0015095 magnesium ion transmembrane transporter activity 4/6338 20/18639 0.2 0.58816661407384 0.94661393273866 1 GO:0140664 ATP-dependent DNA damage sensor activity 4/6338 20/18639 0.2 0.58816661407384 0.94661393273866 1 GO:0015378 sodium:chloride symporter activity 3/6338 16/18639 0.1875 0.551406200694225 0.946845289926184 1 GO:0043023 ribosomal large subunit binding 3/6338 16/18639 0.1875 0.551406200694225 0.946845289926184 1 GO:0048027 mRNA 5'-UTR binding 5/6338 24/18639 0.208333333333333 0.612673556326917 0.948266727711799 1 GO:0017171 serine hydrolase activity 57/6338 198/18639 0.287878787878788 0.84660345965174 0.9503262518036 1 GO:0004300 enoyl-CoA hydratase activity 2/6338 12/18639 0.166666666666667 0.490138845061534 0.951015805686905 1 GO:0004859 phospholipase inhibitor activity 2/6338 12/18639 0.166666666666667 0.490138845061534 0.951015805686905 1 GO:0097371 MDM2/MDM4 family protein binding 2/6338 12/18639 0.166666666666667 0.490138845061534 0.951015805686905 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/6338 12/18639 0.166666666666667 0.490138845061534 0.951015805686905 1 GO:1990817 poly(A) RNA polymerase activity 2/6338 12/18639 0.166666666666667 0.490138845061534 0.951015805686905 1 GO:0030515 snoRNA binding 7/6338 32/18639 0.21875 0.643307234143263 0.953798336051716 1 GO:0031406 carboxylic acid binding 53/6338 187/18639 0.283422459893048 0.833498142938865 0.958935210781767 1 GO:0015271 outward rectifier potassium channel activity 5/6338 25/18639 0.2 0.58816661407384 0.960123604416191 1 GO:0017056 structural constituent of nuclear pore 5/6338 25/18639 0.2 0.58816661407384 0.960123604416191 1 GO:0009881 photoreceptor activity 3/6338 17/18639 0.176470588235294 0.518970541829859 0.960865988860814 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 3/6338 17/18639 0.176470588235294 0.518970541829859 0.960865988860814 1 GO:0030548 acetylcholine receptor regulator activity 3/6338 17/18639 0.176470588235294 0.518970541829859 0.960865988860814 1 GO:0008236 serine-type peptidase activity 55/6338 194/18639 0.283505154639175 0.833741334383021 0.961293211333741 1 GO:0005416 amino acid:monoatomic cation symporter activity 6/6338 29/18639 0.206896551724138 0.608448221455697 0.961545217483179 1 GO:0003743 translation initiation factor activity 12/6338 51/18639 0.235294117647059 0.691960722439812 0.961667577773039 1 GO:0042379 chemokine receptor binding 18/6338 72/18639 0.25 0.7352082675923 0.961991934904391 1 GO:0015291 secondary active transmembrane transporter activity 84/6338 287/18639 0.292682926829268 0.860731630351961 0.962873807679921 1 GO:0002161 aminoacyl-tRNA editing activity 2/6338 13/18639 0.153846153846154 0.452435856979877 0.965362219437468 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/6338 13/18639 0.153846153846154 0.452435856979877 0.965362219437468 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/6338 13/18639 0.153846153846154 0.452435856979877 0.965362219437468 1 GO:0140666 annealing activity 2/6338 13/18639 0.153846153846154 0.452435856979877 0.965362219437468 1 GO:0043177 organic acid binding 53/6338 189/18639 0.28042328042328 0.824678056770199 0.966936164094355 1 GO:0008970 phospholipase A1 activity 4/6338 22/18639 0.181818181818182 0.534696921885309 0.969650601267554 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 17/6338 70/18639 0.242857142857143 0.714202317089663 0.970438628962879 1 GO:0046982 protein heterodimerization activity 109/6338 369/18639 0.295392953929539 0.868701367670035 0.971298939980351 1 GO:0004970 glutamate-gated receptor activity 3/6338 18/18639 0.166666666666667 0.490138845061534 0.971350468053046 1 GO:0015373 monoatomic anion:sodium symporter activity 3/6338 18/18639 0.166666666666667 0.490138845061534 0.971350468053046 1 GO:0022851 GABA-gated chloride ion channel activity 3/6338 18/18639 0.166666666666667 0.490138845061534 0.971350468053046 1 GO:0099602 neurotransmitter receptor regulator activity 3/6338 18/18639 0.166666666666667 0.490138845061534 0.971350468053046 1 GO:0005501 retinoid binding 8/6338 38/18639 0.210526315789474 0.619122751656674 0.97266689227184 1 GO:0019840 isoprenoid binding 8/6338 38/18639 0.210526315789474 0.619122751656674 0.97266689227184 1 GO:0031491 nucleosome binding 18/6338 74/18639 0.243243243243243 0.71533777387359 0.972983122381845 1 GO:0016860 intramolecular oxidoreductase activity 12/6338 53/18639 0.226415094339623 0.665848997064725 0.974250069446088 1 GO:0005344 oxygen carrier activity 2/6338 14/18639 0.142857142857143 0.420119010052743 0.975617268494912 1 GO:0008392 arachidonate epoxygenase activity 2/6338 14/18639 0.142857142857143 0.420119010052743 0.975617268494912 1 GO:0043176 amine binding 2/6338 14/18639 0.142857142857143 0.420119010052743 0.975617268494912 1 GO:1990825 sequence-specific mRNA binding 2/6338 14/18639 0.142857142857143 0.420119010052743 0.975617268494912 1 GO:0004601 peroxidase activity 13/6338 57/18639 0.228070175438596 0.67071631429473 0.976201857575868 1 GO:0008395 steroid hydroxylase activity 5/6338 27/18639 0.185185185185185 0.544598716735037 0.976697862004781 1 GO:0016917 GABA receptor activity 4/6338 23/18639 0.173913043478261 0.511449229629426 0.977305218377551 1 GO:0099186 structural constituent of postsynapse 4/6338 23/18639 0.173913043478261 0.511449229629426 0.977305218377551 1 GO:0016836 hydro-lyase activity 14/6338 61/18639 0.229508196721311 0.674945294838833 0.978035964189383 1 GO:0019842 vitamin binding 40/6338 150/18639 0.266666666666667 0.784222152098454 0.978481522931165 1 GO:0004890 GABA-A receptor activity 3/6338 19/18639 0.157894736842105 0.464342063742506 0.979132748826112 1 GO:0034987 immunoglobulin receptor binding 3/6338 19/18639 0.157894736842105 0.464342063742506 0.979132748826112 1 GO:0016829 lyase activity 55/6338 200/18639 0.275 0.808729094351531 0.980092122055312 1 GO:0005504 fatty acid binding 10/6338 47/18639 0.212765957446809 0.625709163908341 0.980610805373044 1 GO:0008135 translation factor activity, RNA binding 20/6338 83/18639 0.240963855421687 0.708634474787759 0.980985293816017 1 GO:0008514 organic anion transmembrane transporter activity 76/6338 269/18639 0.282527881040892 0.830867335866392 0.981951192917362 1 GO:0004089 carbonate dehydratase activity 2/6338 15/18639 0.133333333333333 0.392111076049227 0.982904166461404 1 GO:0015116 sulfate transmembrane transporter activity 2/6338 15/18639 0.133333333333333 0.392111076049227 0.982904166461404 1 GO:0015250 water channel activity 2/6338 15/18639 0.133333333333333 0.392111076049227 0.982904166461404 1 GO:0050997 quaternary ammonium group binding 8/6338 40/18639 0.2 0.58816661407384 0.982983022210507 1 GO:0140662 ATP-dependent protein folding chaperone 8/6338 40/18639 0.2 0.58816661407384 0.982983022210507 1 GO:0180051 translation factor activity 20/6338 84/18639 0.238095238095238 0.700198350087905 0.984035579036141 1 GO:0015459 potassium channel regulator activity 13/6338 59/18639 0.220338983050847 0.647980168047451 0.984123953289922 1 GO:0003796 lysozyme activity 1/6338 10/18639 0.1 0.29408330703692 0.984345556569368 1 GO:0008519 ammonium channel activity 1/6338 10/18639 0.1 0.29408330703692 0.984345556569368 1 GO:0015187 glycine transmembrane transporter activity 1/6338 10/18639 0.1 0.29408330703692 0.984345556569368 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/6338 10/18639 0.1 0.29408330703692 0.984345556569368 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/6338 10/18639 0.1 0.29408330703692 0.984345556569368 1 GO:0042166 acetylcholine binding 1/6338 10/18639 0.1 0.29408330703692 0.984345556569368 1 GO:0051378 serotonin binding 1/6338 10/18639 0.1 0.29408330703692 0.984345556569368 1 GO:0015399 primary active transmembrane transporter activity 44/6338 166/18639 0.265060240963855 0.779497922266535 0.984891509122227 1 GO:0016874 ligase activity 44/6338 167/18639 0.263473053892216 0.774830270037394 0.98675360839124 1 GO:0008391 arachidonate monooxygenase activity 2/6338 16/18639 0.125 0.36760413379615 0.988055434537864 1 GO:0005544 calcium-dependent phospholipid binding 11/6338 53/18639 0.207547169811321 0.610361580642665 0.988265261950405 1 GO:0070182 DNA polymerase binding 3/6338 21/18639 0.142857142857143 0.420119010052743 0.989078126043326 1 GO:0016835 carbon-oxygen lyase activity 18/6338 79/18639 0.227848101265823 0.670063231223362 0.989116723854611 1 GO:0015020 glucuronosyltransferase activity 6/6338 34/18639 0.176470588235294 0.518970541829859 0.989565437164306 1 GO:0005536 D-glucose binding 1/6338 11/18639 0.0909090909090909 0.267348460942655 0.989671546287729 1 GO:0016594 glycine binding 1/6338 11/18639 0.0909090909090909 0.267348460942655 0.989671546287729 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/6338 11/18639 0.0909090909090909 0.267348460942655 0.989671546287729 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/6338 11/18639 0.0909090909090909 0.267348460942655 0.989671546287729 1 GO:0098918 structural constituent of synapse 5/6338 30/18639 0.166666666666667 0.490138845061534 0.9899623086067 1 GO:0048020 CCR chemokine receptor binding 10/6338 50/18639 0.2 0.58816661407384 0.990205806965755 1 GO:0008569 minus-end-directed microtubule motor activity 2/6338 17/18639 0.117647058823529 0.345980361219906 0.991680693961471 1 GO:0005125 cytokine activity 63/6338 234/18639 0.269230769230769 0.791762749714785 0.992020046418899 1 GO:0004867 serine-type endopeptidase inhibitor activity 22/6338 95/18639 0.231578947368421 0.681035026822341 0.992092510040765 1 GO:0005243 gap junction channel activity 3/6338 22/18639 0.136363636363636 0.401022691413982 0.99214562995529 1 GO:0005272 sodium channel activity 10/6338 51/18639 0.196078431372549 0.57663393536651 0.992257331313732 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 20/6338 88/18639 0.227272727272727 0.668371152356637 0.992289139927177 1 GO:0047499 calcium-independent phospholipase A2 activity 5/6338 31/18639 0.161290322580645 0.474327914575678 0.992483546999912 1 GO:0036002 pre-mRNA binding 12/6338 59/18639 0.203389830508475 0.598135539736109 0.992871404171696 1 GO:0015103 inorganic anion transmembrane transporter activity 42/6338 165/18639 0.254545454545455 0.748575690639433 0.993093825756267 1 GO:0004032 aldose reductase (NADPH) activity 1/6338 12/18639 0.0833333333333333 0.245069422530767 0.993185704524167 1 GO:0005436 sodium:phosphate symporter activity 1/6338 12/18639 0.0833333333333333 0.245069422530767 0.993185704524167 1 GO:0015269 calcium-activated potassium channel activity 1/6338 12/18639 0.0833333333333333 0.245069422530767 0.993185704524167 1 GO:0004252 serine-type endopeptidase activity 45/6338 176/18639 0.255681818181818 0.751917546401216 0.993875655472477 1 GO:0020037 heme binding 35/6338 142/18639 0.246478873239437 0.724853221569874 0.993962748600897 1 GO:0005372 water transmembrane transporter activity 2/6338 18/18639 0.111111111111111 0.326759230041022 0.994221972200024 1 GO:0017128 phospholipid scramblase activity 2/6338 18/18639 0.111111111111111 0.326759230041022 0.994221972200024 1 GO:1901611 phosphatidylglycerol binding 2/6338 18/18639 0.111111111111111 0.326759230041022 0.994221972200024 1 GO:0015106 bicarbonate transmembrane transporter activity 5/6338 32/18639 0.15625 0.459505167245188 0.994393108478004 1 GO:0004993 G protein-coupled serotonin receptor activity 1/6338 13/18639 0.0769230769230769 0.226217928489939 0.995504328281392 1 GO:0005542 folic acid binding 1/6338 13/18639 0.0769230769230769 0.226217928489939 0.995504328281392 1 GO:0009055 electron transfer activity 27/6338 116/18639 0.232758620689655 0.684504249137659 0.995584120647964 1 GO:0046906 tetrapyrrole binding 37/6338 152/18639 0.243421052631579 0.715860681603029 0.996284018873599 1 GO:0005253 monoatomic anion channel activity 23/6338 103/18639 0.223300970873786 0.656690879791181 0.99650434465767 1 GO:0015108 chloride transmembrane transporter activity 28/6338 121/18639 0.231404958677686 0.680523355126757 0.996581703842341 1 GO:0061783 peptidoglycan muralytic activity 1/6338 14/18639 0.0714285714285714 0.210059505026372 0.997034102111121 1 GO:1901612 cardiolipin binding 1/6338 14/18639 0.0714285714285714 0.210059505026372 0.997034102111121 1 GO:0046943 carboxylic acid transmembrane transporter activity 47/6338 188/18639 0.25 0.7352082675923 0.997104661869952 1 GO:0005342 organic acid transmembrane transporter activity 47/6338 189/18639 0.248677248677249 0.731318276758479 0.997502038677407 1 GO:0022804 active transmembrane transporter activity 128/6338 457/18639 0.280087527352298 0.823690663035575 0.997662920179775 1 GO:0004623 phospholipase A2 activity 5/6338 35/18639 0.142857142857143 0.420119010052743 0.997721025903555 1 GO:0005227 calcium-activated cation channel activity 3/6338 26/18639 0.115384615384615 0.339326892734908 0.997967528478767 1 GO:0008066 glutamate receptor activity 3/6338 26/18639 0.115384615384615 0.339326892734908 0.997967528478767 1 GO:0008020 G protein-coupled photoreceptor activity 1/6338 15/18639 0.0666666666666667 0.196055538024613 0.998043383228958 1 GO:0008509 monoatomic anion transmembrane transporter activity 35/6338 149/18639 0.23489932885906 0.690799714516255 0.998057632680953 1 GO:0005248 voltage-gated sodium channel activity 2/6338 21/18639 0.0952380952380952 0.280079340035162 0.99809182361797 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/6338 31/18639 0.129032258064516 0.379462331660542 0.998093449113005 1 GO:0022843 voltage-gated monoatomic cation channel activity 33/6338 143/18639 0.230769230769231 0.678653785469816 0.998380444035981 1 GO:0004812 aminoacyl-tRNA ligase activity 6/6338 41/18639 0.146341463414634 0.430365815175981 0.998577753145565 1 GO:0008227 G protein-coupled amine receptor activity 6/6338 41/18639 0.146341463414634 0.430365815175981 0.998577753145565 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 6/6338 41/18639 0.146341463414634 0.430365815175981 0.998577753145565 1 GO:0047498 calcium-dependent phospholipase A2 activity 4/6338 32/18639 0.125 0.36760413379615 0.99862206920372 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/6338 16/18639 0.0625 0.183802066898075 0.998709246475031 1 GO:0022829 wide pore channel activity 5/6338 37/18639 0.135135135135135 0.397409874374216 0.998768937909128 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 7/6338 46/18639 0.152173913043478 0.447518075925748 0.998821810642095 1 GO:0015294 solute:monoatomic cation symporter activity 25/6338 116/18639 0.21551724137931 0.633800230683017 0.99883634823614 1 GO:0005254 chloride channel activity 16/6338 83/18639 0.192771084337349 0.566907579830208 0.999002883800837 1 GO:0022832 voltage-gated channel activity 41/6338 175/18639 0.234285714285714 0.688995176486499 0.999145190277874 1 GO:0022853 active monoatomic ion transmembrane transporter activity 25/6338 118/18639 0.211864406779661 0.62305785389178 0.999215654228044 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/6338 34/18639 0.117647058823529 0.345980361219906 0.999285953483412 1 GO:0005244 voltage-gated monoatomic ion channel activity 40/6338 173/18639 0.23121387283237 0.679961403553573 0.999339414442181 1 GO:0022839 monoatomic ion-gated channel activity 3/6338 30/18639 0.1 0.29408330703692 0.999495917499819 1 GO:0015293 symporter activity 32/6338 146/18639 0.219178082191781 0.644566152409688 0.999507324849226 1 GO:0071855 neuropeptide receptor binding 5/6338 40/18639 0.125 0.36760413379615 0.99952114304854 1 GO:0005251 delayed rectifier potassium channel activity 2/6338 25/18639 0.08 0.235266645629536 0.999575820535977 1 GO:0005229 intracellularly calcium-gated chloride channel activity 1/6338 19/18639 0.0526315789473684 0.154780687914169 0.999629503785913 1 GO:0099589 serotonin receptor activity 1/6338 19/18639 0.0526315789473684 0.154780687914169 0.999629503785913 1 GO:0141147 intracellularly calcium-gated channel activity 1/6338 19/18639 0.0526315789473684 0.154780687914169 0.999629503785913 1 GO:0005184 neuropeptide hormone activity 3/6338 31/18639 0.0967741935483871 0.284596748745407 0.999646181969835 1 GO:0031492 nucleosomal DNA binding 5/6338 42/18639 0.119047619047619 0.350099175043953 0.999747920170579 1 GO:0160041 neuropeptide activity 3/6338 32/18639 0.09375 0.275703100347113 0.999752124669778 1 GO:0005326 neurotransmitter transmembrane transporter activity 1/6338 20/18639 0.05 0.14704165351846 0.999755615762545 1 GO:0015464 acetylcholine receptor activity 1/6338 20/18639 0.05 0.14704165351846 0.999755615762545 1 GO:0015252 proton channel activity 2/6338 27/18639 0.0740740740740741 0.217839486694015 0.999801782416162 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 8/6338 58/18639 0.137931034482759 0.405632147637131 0.999871216547812 1 GO:0019825 oxygen binding 3/6338 34/18639 0.0882352941176471 0.25948527091493 0.999878982026798 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 10/6338 68/18639 0.147058823529412 0.432475451524883 0.999909001494688 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/6338 36/18639 0.0833333333333333 0.245069422530767 0.999941293821909 1 GO:0015078 proton transmembrane transporter activity 39/6338 185/18639 0.210810810810811 0.619959404023778 0.999961928700962 1 GO:0015079 potassium ion transmembrane transporter activity 32/6338 160/18639 0.2 0.58816661407384 0.999969353216376 1 GO:0005249 voltage-gated potassium channel activity 16/6338 98/18639 0.163265306122449 0.480136011488849 0.999974087734686 1 GO:0005267 potassium channel activity 22/6338 124/18639 0.17741935483871 0.521760706033245 0.999983035139573 1 GO:0001653 peptide receptor activity 23/6338 128/18639 0.1796875 0.528430942331966 0.999983168215995 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6/6338 56/18639 0.107142857142857 0.315089257539557 0.999987109512054 1 GO:0008528 G protein-coupled peptide receptor activity 21/6338 122/18639 0.172131147540984 0.506208971129125 0.999989537422017 1 GO:0004497 monooxygenase activity 17/6338 106/18639 0.160377358490566 0.471643039587513 0.999990439934963 1 GO:0008527 taste receptor activity 1/6338 28/18639 0.0357142857142857 0.105029752513186 0.999991251067728 1 GO:0099095 ligand-gated monoatomic anion channel activity 4/6338 47/18639 0.0851063829787234 0.250283665563336 0.99999183686679 1 GO:0022824 transmitter-gated monoatomic ion channel activity 7/6338 63/18639 0.111111111111111 0.326759230041022 0.999993476776344 1 GO:0022835 transmitter-gated channel activity 7/6338 63/18639 0.111111111111111 0.326759230041022 0.999993476776344 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 5/6338 53/18639 0.0943396226415094 0.277437082110302 0.999993561272796 1 GO:0030280 structural constituent of skin epidermis 2/6338 37/18639 0.0540540540540541 0.158963949749687 0.999995852591116 1 GO:0015370 solute:sodium symporter activity 10/6338 79/18639 0.126582278481013 0.372257350679646 0.999996332135668 1 GO:0003954 NADH dehydrogenase activity 3/6338 44/18639 0.0681818181818182 0.200511345706991 0.999996915056547 1 GO:0099094 ligand-gated monoatomic cation channel activity 23/6338 136/18639 0.169117647058824 0.497346769253615 0.999997550319267 1 GO:0003823 antigen binding 32/6338 174/18639 0.183908045977011 0.540842863516175 0.999998552997702 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 8/6338 73/18639 0.10958904109589 0.322283076204844 0.999998744217432 1 GO:0042923 neuropeptide binding 1/6338 33/18639 0.0303030303030303 0.0891161536475516 0.999998909213768 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/6338 41/18639 0.0487804878048781 0.143455271725327 0.999999135826664 1 GO:0046873 metal ion transmembrane transporter activity 107/6338 450/18639 0.237777777777778 0.699264752287788 0.999999287083141 1 GO:0015081 sodium ion transmembrane transporter activity 28/6338 164/18639 0.170731707317073 0.502093451038644 0.999999635030624 1 GO:0005179 hormone activity 20/6338 132/18639 0.151515151515152 0.445580768237758 0.99999971910889 1 GO:0098960 postsynaptic neurotransmitter receptor activity 6/6338 69/18639 0.0869565217391304 0.255724614814713 0.999999838736396 1 GO:0030594 neurotransmitter receptor activity 11/6338 97/18639 0.11340206185567 0.333496533753208 0.999999938321291 1 GO:0005261 monoatomic cation channel activity 69/6338 341/18639 0.202346041055718 0.595065929194941 0.999999994412032 1 GO:0008188 neuropeptide receptor activity 1/6338 48/18639 0.0208333333333333 0.0612673556326917 0.999999997894846 1 GO:0015276 ligand-gated monoatomic ion channel activity 28/6338 186/18639 0.150537634408602 0.442706053603966 0.999999998644439 1 GO:0022834 ligand-gated channel activity 28/6338 188/18639 0.148936170212766 0.437996414735839 0.999999999203562 1 GO:0022836 gated channel activity 59/6338 318/18639 0.185534591194969 0.545626261483594 0.999999999764384 1 GO:0005216 monoatomic ion channel activity 92/6338 448/18639 0.205357142857143 0.603921076950818 0.999999999921863 1 GO:0003730 mRNA 3'-UTR binding 39/6338 262/18639 0.148854961832061 0.43775759444427 0.999999999999433 1 GO:0003735 structural constituent of ribosome 12/6338 175/18639 0.0685714285714286 0.201657124825317 1 1 GO:0030371 translation repressor activity 16/6338 329/18639 0.0486322188449848 0.143019237464764 1 1 GO:0045182 translation regulator activity 24/6338 356/18639 0.0674157303370786 0.198258409238373 1 1 GO:1903231 mRNA base-pairing translational repressor activity 3/6338 298/18639 0.0100671140939597 0.0296057020506967 1 1