category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	117/1837	250/9376	2.38865977136636	HEXB/CTSA/AP3S1/LAMP2/LGMN/CTSZ/LAMP1/ATP6V0D1/CLTB/BLOC1S6/AGA/RRAGC/GNS/VAMP8/SLC17A5/IDS/ATP6V0E1/LAPTM4A/PSAP/CD63/ARL8B/GAA/CTSB/ATP6AP1/GNPTG/ASAH1/NAGLU/HEXA/CLTC/SCARB2/HGSNAT/GLB1/CTSH/OSTM1/AP2B1/CTSD/AP2A2/IGF2R/OSBP/ENTPD4/BLOC1S1/SNAP29/FUCA2/VAMP7/SLC15A3/ATP6V1G1/ARSA/TPP1/GUSB/NEU1/ATP6V1B2/CTSF/FUCA1/AP1G1/CD68/ATP6V1D/RRAGA/GALNS/OSBPL2/LAMTOR3/RAB7A/LAMTOR4/ATP6V1E1/BLOC1S4/SLC29A3/VPS35/MCOLN1/NAGA/CLCN7/CTSS/GGA1/GGA2/ATP6V1C1/ATP6V0B/AKT1S1/SLC11A2/AP1B1/LAPTM5/SNAPIN/NPC1/AP4E1/SLC15A4/DTNBP1/ATP6V0A1/STX17/VPS26B/MTOR/SMPD1/AP1M1/PLEKHM1/VPS39/DMXL1/SPG11/NAGPA/NPC2/SUMF1/CD164/CTSO/AP5S1/VPS11/GGA3/AP5M1/TMEM175/TFE3/SLC11A1/CTNS/RPTOR/MITF/TPCN1/ATP6V1E2/ABCA5/ZFYVE26/BLOC1S3/WDR7/DEPTOR/RRAGD/GPR155	10.9852253707866
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	90/1837	169/9376	2.71809259372594	MAPK3/GABARAPL2/SQSTM1/LAMP2/PPP2CB/MAP1LC3B/RHEB/EIF2AK4/RB1CC1/LAMP1/PIK3R1/RRAGC/VAMP8/GABARAP/DAPK1/GORASP2/CTSB/UBC/AKT3/OPTN/PDPK1/CTSD/RAB1A/IRS2/NBR1/MAPK8/CFLAR/GABARAPL1/SNAP29/MAP2K1/WIPI1/STX7/TAX1BP1/BECN1/CALCOCO2/BIRC6/RRAGA/PIK3CB/DAPK3/MAPK1/ATG5/PIK3CA/RAB7A/PPP2CA/RAF1/MAPK9/BAD/MAP3K7/ATG13/RPS6KB2/WDR45B/RRAS2/ATG12/SH3GLB1/SUPT20H/AKT1S1/STK11/CAMKK2/RPS6KB1/STX17/MTOR/PLEKHM1/ULK2/PIK3C3/WDFY3/PRKACA/VPS39/BCL2L1/TSC2/ATG14/ATG16L2/ULK1/ATG2B/EPG5/VPS11/GORASP1/ATG4D/TRAF6/ATG16L1/UBB/ZFYVE1/TP53INP2/ATG9B/RAB33B/MRAS/RPTOR/PIK3CD/PIK3R2/DEPTOR/RRAGD	11.1253630261058
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	110/1837	250/9376	2.24574850299401	ARFGAP3/IL2RB/ASAP3/SH3GL1/EGFR/RAB5A/CLTB/CAV2/HLA-B/ARF4/TGFBR1/HSPA1B/SH3GLB2/CLTC/FOLR1/RABEP1/AP2B1/IST1/AP2A2/RAB22A/IQSEC1/IGF2R/PDCD6IP/WASL/GRK4/CHMP1A/SMAD3/CHMP3/SMAD2/CYTH2/VPS4B/WIPF1/CHMP4C/VPS37A/CBL/LDLR/EPN2/TSG101/WIPF2/DNM2/EHD1/STAM/GIT1/USP8/ARFGEF1/RAB11B/SH3KBP1/ARPC2/PARD3/RAB5B/CYTH3/CHMP2B/GBF1/VPS4A/RAB7A/CYTH1/HGS/GIT2/ARF1/SMAP1/ITCH/TGFBR2/VPS36/CHMP1B/STAMBP/ARFGAP1/MDM2/VPS35/ARFGEF2/SH3GLB1/HLA-E/RUFY1/PRKCI/SMAP2/ARPC1B/EHD3/PARD6B/CHMP5/HSPA1A/VTA1/VPS37B/CXCR4/SMURF1/AGAP3/VPS26B/WWP1/ARAP1/SNX3/ACAP3/SNX12/SMURF2/PLD1/RAB11FIP1/EPS15L1/HSPA6/PARD6G/EHD4/TRAF6/ARAP2/PIP5KL1/ZFYVE27/DNAJC6/RHOA/NEDD4L/ACAP1/HLA-F/ASAP2/ACTR3C/IL2RG/PIP5K1B	9.8547018808244
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	66/1837	142/9376	2.37226954541621	ANAPC13/HERC1/DDB1/UBE2A/ANAPC16/UBE2K/CDC34/UBC/UBE2R2/UBE2H/UBE2D1/XIAP/SOCS1/TRIP12/UBE2E2/UBE2J1/UBE2Q2/UBE2Q1/STUB1/CBL/HUWE1/UBE2G2/CUL5/SYVN1/UBE2B/FBXW11/BIRC6/UBE3A/CUL4B/UBE2Z/CDC26/UBR5/ITCH/UBE2L6/UBE2E1/BIRC7/UBE2G1/MDM2/UBE3C/UBE2D2/CDC16/UBE2W/UBE2D3/SMURF1/WWP1/UBE2D4/FBXW8/KLHL9/UBE3B/UBE4B/PIAS1/BTRC/SMURF2/MID1/SKP1/SOCS3/WWP2/TRAF6/UBB/TRIM32/CUL7/PIAS3/NEDD4L/UBOX5/DET1/FBXO2	8.13339767019331
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	58/1837	119/9376	2.48765113013088	MAPK3/CREB5/PIK3R1/BCL3/FOS/ATF4/TNFRSF1A/CREB3L2/IRF1/AKT3/NFKBIA/XIAP/TRADD/MAPK8/MAP2K3/JUNB/CFLAR/MAP2K1/DAB2IP/CREB3/PIK3CB/MAPK1/CEBPB/PIK3CA/RELA/MAPK9/MAP3K7/ITCH/RHBDF1/NFKB1/TNFAIP3/BAG4/ATF6B/CASP7/ATF2/FADD/TAB2/RIPK1/MAPK14/CCL5/MAP2K4/CXCL2/IKBKG/CYLD/RPS6KA5/MMP9/CHUK/SOCS3/TAB3/MAP3K5/JUN/IL18R1/ICAM1/PIK3CD/PIK3R2/EDN1/CXCL10/MLKL	8.06162866971104
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	120/1837	333/9376	1.83926986322196	SPP1/MAPK3/PPP2CB/CDKN1A/CREB5/RHEB/EGFR/ATP6V0D1/PIK3R1/PTK2/HLA-B/HES2/LLGL2/ATP6V0E1/ITGB1/FN1/PPP2R5E/STAT1/HES4/ATP6AP1/TNFRSF1A/CREB3L2/IRF1/AKT3/TCF7L2/LAMA5/IFNAR1/EP300/TRADD/LAMC1/CHD4/MAML2/NOTCH2/RBPJ/RBL2/EIF2AK2/MAP2K1/ATP6V1G1/CSNK1A1/RB1/SOS1/FOXO1/DVL1/CREB3/ATP6V1B2/CREBBP/UBR4/ATP6V1D/PARD3/UBE3A/PIK3CB/MAPK1/PIK3CA/PPP2CA/RAF1/RELA/BAD/IRF3/ATP6V1E1/RPS6KB2/JAK1/MDM2/TADA3/HLA-E/PRKCI/ITGA3/PARD6B/ATP6V1C1/ATP6V0B/NFKB1/PPP2R5A/SOS2/APC/COL4A2/PPP2R2D/FADD/PSEN1/PPP2R3C/ATP6V0A1/RPS6KB1/MX2/MTOR/LAMA3/ITGB4/PRKACA/TBP/LAMB2/IKBKG/BCAP31/ITGA2/MAML1/COL4A1/ITGB6/TSC2/TCF7L1/LAMC2/CHUK/PARD6G/GNAS/ITGA5/TCF7/THBS3/LAMB3/WNT2B/PPP2R5B/ISG15/ATP6V1E2/PIK3CD/FZD8/TICAM1/TUBG2/PTGER4/PIK3R2/WNT6/HLA-F/LFNG/WNT9A/WNT5B/FZD9/FZD10	7.69751997617153
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	98/1837	253/9376	1.97703335692969	MAPK3/SQSTM1/MAP1LC3B/EGFR/PIK3R1/PTK2/IL1R1/PLCD3/RRAGC/CAPN2/FOXO3/ITGB1/UBC/ITPR2/TNFRSF1A/AKT3/NFKBIA/UBE2D1/TECPR1/TRADD/MAPK8/FNBP1/WASL/CYTH2/WIPI1/RBCK1/CAST/FOXO1/BCAR1/BECN1/CALCOCO2/ARHGEF2/FBXW11/CAPNS1/ARPC2/RRAGA/CRK/CYTH3/DIAPH1/PIK3CB/MAPK1/ATG5/WASF2/PIK3CA/CYTH1/FNBP1L/RELA/MAPK9/IRF3/ARF1/UBE2V2/MAP3K7/RPS6KB2/TLN2/MDM2/ATG12/ARPC1B/UBE2D2/TNIP1/GSK3A/NFKB1/AKT1S1/CRKL/UBE2D3/TAB2/NFKBIB/RIPK1/RPS6KB1/MAPK14/UBE2D4/MTOR/CCL5/PIK3C3/IKBKG/U2AF1L4/BCL2L1/BTRC/ATG14/SKP1/RPS6KA5/CHUK/TAB3/RAC1/ITGA5/JUN/TRAF6/ATG16L1/UBB/PRKCE/RPTOR/RHOA/PIK3CD/ELMO2/PIK3R2/WASF1/MYL2/ACTR3C/RRAGD	7.77649969117711
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	75/1837	174/9376	2.19998873725902	SEC31A/OS9/HERPUD1/BCAP29/SEC63/SEC24D/CAPN2/MAN1A1/HSPA1B/MBTPS1/ATF4/TRAM1/SEC23A/SEC24A/UBE2D1/DNAJB1/PPP1R15A/DNAJB2/MAPK8/SEC62/SAR1B/UBE2J1/XBP1/RAD23B/AMFR/STUB1/SEL1L/UBXN6/EDEM3/UBE2G2/RRBP1/SYVN1/UGGT2/HSPH1/SEC13/UBXN2A/CKAP4/UBQLN1/MAPK9/NFE2L2/ATF6/RPN1/MAGT1/UBE2G1/DNAJC1/UBE2D2/SSR1/HSPA1A/DNAJC5/ATF6B/DERL3/RNF185/UBE2D3/CRYAB/UBE2D4/RPN2/UBQLN2/UBQLN4/UBE4B/SEC24B/BCAP31/SEC24C/DDIT3/DDOST/SKP1/FBXO6/HSPA6/SSR4/MAP3K5/TXNDC5/YOD1/SEC61G/FBXO2/DNAJA1/HSP90AA1	7.88667644945869
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	55/1837	112/9376	2.50641573994867	MAPK3/IFNGR2/HLA-DRA/TGFB2/HSPA1B/ITGB1/STAT1/TNFRSF1A/AKT3/NFKBIA/HLA-DPA1/PDPK1/LAMA5/XIAP/SOCS1/LAMC1/MAPK8/MAP2K3/IFNGR1/LDLR/GNAI2/HLA-DPB1/STAT3/IL10RB/HLA-DRB1/MAPK1/RELA/MAPK9/BAD/MAP3K7/JAK1/BIRC7/NFKB1/HSPA1A/TAB2/NFKBIB/MAPK14/LAMA3/HLA-DMA/LAMB2/IKBKG/BCL2L1/HLA-DQB1/HLA-DQA1/LAMC2/CHUK/HSPA6/HLA-DMB/TRAF6/JAK2/LAMB3/HLA-DQA2/LY96/CD40/ALOX5	7.91658588441287
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	54/1837	109/9376	2.52857421104413	MAPK3/IL6ST/IL2RB/IFNGR2/IL1RAP/IL1R1/HLA-DRA/EBI3/TGFBR1/FOS/STAT1/RXRA/GATA3/NFKBIA/HLA-DPA1/SMAD4/MAPK8/SMAD3/SMAD2/IFNGR1/HLA-DPB1/STAT3/HLA-DRB1/MAPK1/RELA/MAPK9/RXRB/IL4R/TGFBR2/JAK1/RUNX1/PPP3R1/NFKB1/STAT6/RARA/PPP3CB/IL27RA/PPP3CC/NFKBIB/MAPK14/MTOR/NFATC3/HLA-DMA/IKBKG/HLA-DQB1/HLA-DQA1/CHUK/HLA-DMB/JUN/IL27/JAK2/HLA-DQA2/IL2RG/HSP90AA1	7.92343574512581
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	52/1837	105/9376	2.52768229774218	GABARAPL2/PINK1/SQSTM1/MAP1LC3B/RAB5A/FOXO3/GABARAP/FIS1/BNIP3L/ATF4/UBC/CSNK2A2/OPTN/NBR1/MAPK8/GABARAPL1/AMFR/TBC1D15/HUWE1/TAX1BP1/USP8/CITED2/BECN1/CALCOCO2/RAB5B/RAB7A/RELA/MAPK9/RRAS2/CCZ1/CCZ1B/SP1/FKBP8/ARIH1/RHOT1/MFN1/MUL1/SMURF1/MON1B/MFN2/BCL2L1/SMURF2/TBC1D17/ULK1/NLRX1/JUN/UBB/TFE3/ATG9B/MRAS/MITF/USP30	7.77047826301134
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	87/1837	224/9376	1.98234699432304	MAPK3/ANAPC13/IL2RB/CDKN1A/CREB5/ANAPC16/PIK3R1/IL1R1/HLA-B/HLA-DRA/TGFB2/TGFBR1/FOS/IL1R2/TSPO/ADCY7/ATF4/TNFRSF1A/CREB3L2/AKT3/NFKBIA/EGR1/HLA-DPA1/ETS2/XIAP/EP300/SMAD4/MAPK8/SMAD3/SMAD2/MAP2K1/HLA-DPB1/ZFP36/RB1/CREB3/CREBBP/HLA-DRB1/PIK3CB/MAPK1/PIK3CA/CDC26/RELA/MAPK9/VAC14/TGFBR2/JAK1/TLN2/LTBR/HLA-E/PPP3R1/KAT5/NFKB1/CDC16/NFKB2/ELK4/ATF6B/PPP3CB/ATF2/PPP3CC/B2M/NFATC3/MAP2K4/POLB/HLA-DMA/PRKACA/TBP/IKBKG/BCL2L1/HLA-DQB1/HLA-DQA1/CHUK/MAP3K3/HLA-DMB/JUN/ITGB2/RELB/CDKN2B/KAT2B/ICAM1/PIK3CD/HLA-DQA2/CD40/PIK3R2/MMP7/ADCY9/HLA-F/IL2RG	7.34538001132258
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	93/1837	248/9376	1.91399020141535	TUBB2A/TNFSF10/MAPK3/DYNLT1/DYNC1LI2/RHOB/RAB5A/PKN1/AHNAK/FOS/TXN/ARL8B/TNFRSF1A/AKT3/TCF7L2/NFKBIA/TRADD/MAPK8/MAP2K3/ACBD3/AHNAK2/WASL/CYTH2/MAP2K1/DYNC1H1/DNM2/NCKAP1/DCTN6/PLEKHM2/ARPC2/KPNA4/KPNA3/RAB5B/CYTH3/PIK3CB/SNX9/MAPK1/ABI1/PIK3CA/STX10/RAB7A/CYTH1/DCTN2/RAF1/RELA/MAPK9/ARF1/DCTN1/MAP3K7/MYO6/ACTR10/DYNLRB1/PIK3C2A/DYNLT3/BRK1/ARPC1B/NFKB1/KLC1/CASP7/FADD/TAB2/DCTN4/RIPK1/MAPK14/MAP2K4/PLEKHM1/S100A10/PIK3C3/VPS39/IKBKG/PIK3C2B/SKP1/TCF7L1/CHUK/KLC4/SNX33/TAB3/VPS11/RAC1/JUN/EXOC2/TRAF6/TCF7/RHOA/PIK3CD/LY96/TUBA4A/TNFRSF10A/ELMO2/MYL2/ACTR3C/MLKL/HSP90AA1	7.20050421977986
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	58/1837	137/9376	2.16080645609908	ENDOG/TNFSF10/MAPK3/GADD45B/CSF2RB/CTSZ/PIK3R1/CAPN2/FOS/CTSB/ATF4/ITPR2/TNFRSF1A/CTSH/AKT3/NFKBIA/PDPK1/CTSD/XIAP/GADD45A/TRADD/MAPK8/CFLAR/MAP2K1/DAB2IP/CTSF/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/BAD/CTSS/PARP4/NFKB1/CASP7/MCL1/LMNA/FADD/DAXX/RIPK1/NOL3/IKBKG/BCL2L11/DDIT3/BCL2L1/DFFB/CTSO/CHUK/MAP3K5/JUN/BBC3/DIABLO/PIK3CD/TUBA4A/TNFRSF10A/PIK3R2	6.75602051390552
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	39/1837	77/9376	2.58512962269086	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/TGFB2/TGFBR1/STAT1/AKT3/GADD45A/SMAD4/MAPK8/SMAD3/SMAD2/MAP2K1/RB1/STAT3/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/BAD/RPS6KB2/TGFBR2/JAK1/NFKB1/RALGDS/RPS6KB1/MTOR/IKBKG/BCL2L1/ARAF/PLD1/CHUK/RAC1/PIK3CD/PIK3R2	6.89406486855005
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	42/1837	87/9376	2.46398738573011	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/TGFB2/TGFBR1/FOS/AKT3/TCF7L2/GADD45A/SMAD4/MAPK8/SMAD3/SMAD2/MAP2K1/SOS1/PIK3CB/MAPK1/PIK3CA/APPL1/RAF1/MAPK9/BAD/RPS6KB2/TGFBR2/SOS2/APC/RALGDS/RPS6KB1/MTOR/BCL2L11/ARAF/TCF7L1/RAC1/JUN/TCF7/BBC3/RHOA/PIK3CD/PIK3R2/EREG	6.77167060087339
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	102/1837	300/9376	1.73535111594992	RASGRF2/MAPK3/GADD45B/RASA1/GNG12/IL1RAP/EGFR/IL1R1/DUSP1/TGFB2/MAP3K2/TGFBR1/HSPB1/PDGFB/HSPA1B/JUND/FLT1/FOS/IGF2/ATF4/PAK2/TNFRSF1A/AKT3/GADD45A/FGFR1/ERBB3/TRADD/MAPK8/MAP2K3/VEGFB/TAOK1/MAP2K1/RAP1B/STK3/SOS1/TAOK3/MAX/CRK/MAPK1/MAPK8IP3/LAMTOR3/DUSP3/RAF1/RELA/CSF1R/MAPK9/RAPGEF2/MAP3K7/TGFBR2/RRAS2/MAPK8IP2/DUSP4/PPM1A/PPP3R1/MAPKAPK2/NFKB1/HSPA1A/SOS2/RPS6KA3/NFKB2/MAP4K3/CRKL/ELK4/PPP3CB/ATF2/DAXX/TAB2/PPP3CC/MET/MAPK14/NFATC3/MAP2K4/PRKACA/IKBKG/DDIT3/ARAF/RPS6KA5/MAP3K9/MAP3K10/DUSP7/CHUK/HSPA6/MAP3K5/MAP3K3/RAC1/JUN/TRAF6/RELB/EFNA1/MAP2K5/MRAS/CACNA2D3/CACNA1A/FGF1/PTPRR/MAPT/DUSP10/RASGRF1/EREG/ANGPT2/CACNA1C/PRKCG	6.3898620787661
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	56/1837	133/9376	2.14904162965934	PRKAG2/TNFSF10/MAPK3/GADD45B/GABARAPL2/CDKN1A/EGFR/PIK3R1/TGFB2/FOXO3/GABARAP/TGFBR1/HOMER3/FBXO32/AKT3/PDPK1/IRS2/GADD45A/EP300/PLK3/SMAD4/MAPK8/RBL2/GABARAPL1/SMAD3/MAP2K1/SGK1/SOS1/FOXO1/STAT3/PLK2/CREBBP/PIK3CB/MAPK1/HOMER1/PIK3CA/RAF1/MAPK9/TGFBR2/MDM2/ATG12/SOS2/STK11/BCL6/KLF2/MAPK14/BCL2L11/ARAF/FBXO25/SIRT1/CHUK/CDKN2D/CDKN2B/PIK3CD/PIK3R2/SGK3	6.58777036281584
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	82/1837	227/9376	1.84372624394783	TAPBP/MAPK3/CDKN1A/CREB5/GNG12/RHEB/EGFR/GNAQ/PIK3R1/PTK2/IL1R1/HLA-B/PTGER3/ADCY7/ATF4/ITPR2/TNFRSF1A/TAPBPL/CREB3L2/AKT3/NFKBIA/TRADD/AKAP13/MAP2K1/GNAI2/RB1/SOS1/STAT3/IL10RB/GNA11/CREB3/BCAR1/GNA13/CRK/PIK3CB/MAPK1/PIK3CA/PTK2B/RAF1/RELA/IRF3/RPS6KB2/JAK1/MDM2/HLA-E/SP1/GNB1/PPP3R1/NFKB1/SOS2/CRKL/ATF6B/ARHGEF12/PPP3CB/CXCR4/ATF2/FADD/ARHGEF1/PPP3CC/RIPK1/RPS6KB1/MAPK14/B2M/MTOR/NFATC3/CCL5/GNG10/PRKACA/GNB5/IKBKG/TSC2/CHUK/GNAS/RAC1/RHOA/PIK3CD/PTGER4/PIK3R2/ADCY9/HLA-F/ARHGEF11/PRKCG	6.35200772317446
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	57/1837	138/9376	2.10816312039952	MAPK3/PKN1/GNAQ/PIK3R1/PTK2/ITGB1/FOS/FN1/VAV3/AKT3/NFKBIA/MAPK8/MAP2K3/WASL/MAP2K1/WIPF1/WIPF2/ARHGEF7/BCAR1/ARPC2/CRK/PIK3CB/MAPK1/WASF2/PIK3CA/PTK2B/RELA/GIT2/MAPK9/IRF3/MAP3K7/SKAP2/ARPC1B/NFKB1/RPS6KA3/LIMK1/CRKL/ARHGEF12/ARHGEF1/TAB2/MAPK14/NFATC3/MAP2K4/IKBKG/BAIAP2/CHUK/RAC1/ITGA5/JUN/TRAF6/RHOA/PIK3CD/TICAM1/ELMO2/PIK3R2/ACTR3C/PIP5K1B	6.47347688676017
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	58/1837	142/9376	2.0847217217294	MAPK3/SQSTM1/IFNGR2/FHL2/PIK3R1/IL1R1/TGFB2/FOSB/TGFBR1/JUND/FOS/STAT1/ITPR2/TNFRSF1A/AKT3/NFKBIA/IFNAR1/SOCS1/MAPK8/JUNB/MAP2K1/IFNGR1/PIK3CB/MAPK1/PIK3CA/RELA/CSF1R/MAPK9/MAP3K7/TGFBR2/JAK1/TYROBP/NCF1/PPP3R1/NFKB1/NFKB2/PPP3CB/TAB2/PPP3CC/TMEM64/MAPK14/TREM2/IKBKG/CYLD/CHUK/SOCS3/FCGR3A/RAC1/JUN/TRAF6/RELB/NCF2/MITF/PIK3CD/PIK3R2/LILRB4/LILRB3/OSCAR	6.42911092342728
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	52/1837	122/9376	2.17546427264696	MAPK3/CREB5/GNAQ/PIK3R1/PTK2/CSH1/FOS/STAT1/ADCY7/ATF4/IGFBP3/ITPR2/CREB3L2/AKT3/IRS2/EP300/SOCS1/MAPK8/MAP2K3/JUNB/MAP2K1/GNAI2/SOS1/STAT3/GNA11/CREB3/CREBBP/BCAR1/CSH2/CRK/PIK3CB/MAPK1/PIK3CA/RAF1/MAPK9/SOS2/CRKL/ATF6B/ATF2/MAPK14/MTOR/MAP2K4/PRKACA/SOCS3/GNAS/JAK2/PIK3CD/CSHL1/PIK3R2/ADCY9/CACNA1C/PRKCG	6.45071635715667
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	41/1837	90/9376	2.32514365208976	MAPK3/IFNGR2/EGFR/PIK3R1/FOS/STAT1/CSNK2A2/AKT3/NFKBIA/CD274/MAP2K3/MAP2K1/IFNGR1/STAT3/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/RPS6KB2/JAK1/PPP3R1/NFKB1/PPP3CB/PPP3CC/NFKBIB/RPS6KB1/MAPK14/MTOR/NFATC3/IKBKG/BATF3/CHUK/MAP3K3/JUN/TRAF6/JAK2/PIK3CD/TICAM1/PIK3R2/BATF	6.23524065629866
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	62/1837	163/9376	1.94138883415545	MAPK3/CDKN1A/CREB5/DDB1/PIK3R1/TGFB2/HSPG2/TGFBR1/FOS/STAT1/ATP6AP1/ATF4/CREB3L2/AKT3/NFKBIA/IFNAR1/EP300/SMAD4/STAT4/MAPK8/MAP2K3/SMAD3/MAP2K1/IFIH1/RB1/SOS1/STAT3/CREB3/CREBBP/PIK3CB/MAPK1/PIK3CA/PTK2B/RAF1/RELA/MAPK9/BAD/IRF3/MAP3K7/TGFBR2/JAK1/NFKB1/SOS2/STAT6/ATF6B/ATF2/FADD/TAB2/MAPK14/NFATC3/MAP2K4/IKBKG/ARAF/MMP9/CHUK/JUN/TRAF6/JAK2/PIK3CD/TICAM1/PIK3R2/PRKCG	5.98474504910878
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	72/1837	200/9376	1.83743059335874	TUBB2A/TNFSF10/MAPK3/TJP1/CLDN19/SEC24D/IL1R1/ITGB1/FOS/PAK2/TNFRSF1A/SEC24A/MYO1C/NFKBIA/RAB1A/TRADD/MAPK8/WASL/CYTH2/CLDN4/WIPF1/WIPF2/NCKAP1/LPAR2/ARHGEF2/GNA13/ARPC2/CYTH3/MAPK1/ABI1/WASF2/CYTH1/RELA/MAPK9/ARF1/BAIAP2L1/MAP3K7/MYO6/BRK1/ARPC1B/NFKB1/CASP7/ARHGEF12/FADD/ARHGEF1/TAB2/NFKBIB/RIPK1/MAPK14/IKBKG/SEC24B/SEC24C/BAIAP2/CHUK/TAB3/RAC1/JUN/MYO1D/CLDN9/TRAF6/CLDN23/MYO5B/CLDN14/RHOA/CLDN8/TUBA4A/TNFRSF10A/WASF1/ARHGEF11/CLDN15/ACTR3C/EZR	5.90908806903203
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	60/1837	158/9376	1.9382179254839	MAPK3/RHEB/PIK3R1/LPIN2/RRAGC/TNFRSF1A/AKT3/PDPK1/MAP2K1/ATP6V1G1/SGK1/SOS1/DVL1/ATP6V1B2/SEC13/ATP6V1D/RRAGA/PIK3CB/MAPK1/PIK3CA/LAMTOR3/RAF1/FNIP1/LAMTOR4/ATP6V1E1/MAPKAP1/RPS6KB2/CAB39/SESN2/FNIP2/ATP6V1C1/SOS2/RPS6KA3/AKT1S1/EIF4B/STK11/RPS6KB1/MTOR/WDR59/ULK2/TSC2/ULK1/CHUK/FLCN/WNT2B/LPIN1/RPTOR/ATP6V1E2/RHOA/PIK3CD/FZD8/PIK3R2/WNT6/DEPTOR/RRAGD/WNT9A/WNT5B/FZD9/PRKCG/FZD10	5.87079968896048
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	41/1837	93/9376	2.25013901815138	MAPK3/IL2RB/IFNGR2/HLA-DRA/FOS/STAT1/GATA3/NFKBIA/HLA-DPA1/STAT4/MAPK8/MAML2/NOTCH2/RBPJ/IFNGR1/HLA-DPB1/HLA-DRB1/MAPK1/RELA/MAPK9/IL4R/JAK1/PPP3R1/NFKB1/STAT6/PPP3CB/PPP3CC/NFKBIB/MAPK14/NFATC3/HLA-DMA/IKBKG/MAML1/HLA-DQB1/HLA-DQA1/CHUK/HLA-DMB/JUN/JAK2/HLA-DQA2/IL2RG	5.9805200941653
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	36/1837	77/9376	2.38627349786849	MAPK3/GADD45B/CDKN1A/PIK3R1/TGFB2/TGFBR1/CTBP2/AKT3/NFKBIA/GADD45A/SMAD4/SMAD3/MAP2K1/CBL/RB1/SOS1/CRK/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/BAD/TGFBR2/MDM2/RUNX1/NFKB1/SOS2/CRKL/IKBKG/BCL2L1/ARAF/BCR/CHUK/PIK3CD/PIK3R2	6.02919741265916
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	33/1837	68/9376	2.47692849594928	MAPK3/PIM1/PIK3R1/AKT3/TCF7L2/MAP2K1/CEBPA/SOS1/STAT3/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/CSF1R/BAD/RPS6KB2/JUP/RUNX1/NFKB1/SOS2/RARA/RPS6KB1/MTOR/IKBKG/ARAF/PER2/TCF7L1/CHUK/TCF7/PIK3CD/PIK3R2/ITGAM	6.03349675677894
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	49/1837	122/9376	2.04995671845579	PRKAG2/PPP2CB/CREB5/RHEB/PIK3R1/FOXO3/RAB2A/PPP2R5E/CREB3L2/AKT3/PDPK1/TBC1D1/IRS2/RAB14/CPT1A/ADIPOR1/FOXO1/CREB3/RAB11B/PIK3CB/PIK3CA/PPP2CA/MAP3K7/RPS6KB2/ELAVL1/CAB39/PPP2R5A/AKT1S1/PPP2R2D/STK11/CAMKK2/PPP2R3C/RPS6KB1/PFKFB3/MTOR/MLYCD/TSC2/SIRT1/ULK1/EEF2/CD36/FBP1/PPP2R5B/RPTOR/PIK3CD/ACACB/PIK3R2/CPT1B/PFKFB2	5.76195562524213
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	33/1837	70/9376	2.40615911035073	MAPK3/CDKN1A/PIK3R1/TGFB2/PDGFB/EPAS1/PAK2/ARNT2/AKT3/EP300/MAP2K1/RAP1B/SOS1/EGLN3/CREBBP/CRK/PIK3CB/MAPK1/PIK3CA/RAF1/BAD/SOS2/CRKL/MET/EGLN2/GAB1/ARAF/RAC1/JUN/FLCN/TFE3/PIK3CD/PIK3R2	5.8288825638672
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	69/1837	196/9376	1.79680712785931	MAPK3/IL6ST/MAP1LC3B/CDKN1A/GNG12/PIK3R1/HLA-B/PDGFB/FOS/STAT1/UBC/ITPR2/TNFRSF1A/AKT3/TCF7L2/NFKBIA/IFNAR1/EP300/TRADD/MAPK8/EIF2AK2/MAP2K1/IFNGR1/ZFP36/RB1/STAT3/CREBBP/BECN1/LYN/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/IRF3/JAK1/HLA-E/GNB1/PPP3R1/MAPKAPK2/NFKB1/PPP3CB/FADD/PPP3CC/MAPK14/MTOR/NFATC3/MAP2K4/PIK3C3/GNG10/GNB5/CXCL2/IKBKG/RCAN1/ATG14/TCF7L1/CHUK/RAC1/JUN/TCF7/UBB/JAK2/ICAM1/PIK3CD/TICAM1/PIK3R2/HLA-F/ANGPT2	5.56471914630261
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	62/1837	170/9376	1.86144929392552	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/TGFB2/TGFBR1/IGF2/HMOX1/AKT3/TCF7L2/PBRM1/BRD7/GADD45A/SMAD4/SMAD3/SMAD2/SMARCB1/MAP2K1/CSNK1A1/SMARCE1/RB1/SOS1/DVL1/GSTT1/PIK3CB/MAPK1/PIK3CA/RAF1/BAD/NFE2L2/RPS6KB2/TGFBR2/SMARCD1/SMARCD2/SMARCC2/SOS2/APC/TXNRD2/PHF10/RPS6KB1/FRAT1/MET/MTOR/GSTA3/GAB1/BCL2L1/ARAF/TCF7L1/TCF7/WNT2B/DPF1/PIK3CD/FZD8/TXNRD3/PIK3R2/WNT6/WNT9A/WNT5B/FZD9/PRKCG/FZD10	5.59502510400843
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	39/1837	90/9376	2.21172201052441	PRKAG2/CREB5/RHEB/RB1CC1/PIK3R1/FOXO3/ADCY7/ATF4/CREB3L2/AKT3/IRS2/ADIPOR1/FOXO1/CREB3/PIK3CB/ATG5/PIK3CA/APPL1/RELA/ATG13/RPS6KB2/SESN2/NFKB1/AKT1S1/STK11/ATF6B/ATF2/CAMKK2/RPS6KB1/MTOR/PRKACA/TSC2/SIRT1/ULK1/RPTOR/PIK3CD/SESN3/PIK3R2/ADCY9	5.70155419168242
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	33/1837	71/9376	2.37226954541621	TJP1/JAM2/EGFR/ATP6V0D1/ATP6V0E1/ATP6AP1/NFKBIA/ADAM10/MAPK8/ATP6V1G1/GIT1/ATP6V1B2/LYN/ATP6V1D/RELA/MAPK9/ATP6V1E1/F11R/ATP6V1C1/ATP6V0B/NFKB1/ATP6V0A1/MET/MAPK14/CCL5/MAP2K4/CXCL2/IKBKG/CHUK/RAC1/JUN/ATP6V1E2/HBEGF	5.72919699595879
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	73/1837	214/9376	1.74107519879527	TAPBP/MAPK3/BST2/GNG12/DDB1/GNAQ/PIK3R1/PTK2/HLA-B/FOS/ITPR2/PAK2/TNFRSF1A/TAPBPL/AKT3/NFKBIA/TRADD/MAPK8/MAP2K3/MAP2K1/GNAI2/CUL5/GNA11/AP1G1/FBXW11/CRK/PIK3CB/MAPK1/CUL4B/PIK3CA/PTK2B/RAF1/RELA/MAPK9/BAD/IRF3/MAP3K7/RPS6KB2/HLA-E/GNB1/PPP3R1/NFKB1/LIMK1/AP1B1/CRKL/PPP3CB/CXCR4/FADD/TAB2/PPP3CC/RIPK1/RPS6KB1/MAPK14/B2M/MTOR/NFATC3/AP1M1/GNG10/GNB5/IKBKG/BCL2L1/BTRC/SAMHD1/SKP1/CHUK/RAC1/JUN/TRAF6/PIK3CD/APOBEC3B/PIK3R2/HLA-F/PRKCG	5.41324105390734
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	35/1837	78/9376	2.29024468545427	MAPK3/IFNGR2/HLA-DRA/TGFB2/ITGB1/FOS/STAT1/MARCKSL1/NFKBIA/HLA-DPA1/IFNGR1/HLA-DPB1/HLA-DRB1/MAPK1/RELA/EEF1A1/MAP3K7/JAK1/NCF1/NFKB1/TAB2/NFKBIB/MAPK14/HLA-DMA/HLA-DQB1/HLA-DQA1/FCGR3A/HLA-DMB/JUN/ITGB2/TRAF6/JAK2/NCF2/HLA-DQA2/ITGAM	5.64817252634802
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	62/1837	173/9376	1.8291698264008	TNFSF10/MAPK3/IFNGR2/PIK3R1/HLA-DRA/STAT1/TNFRSF1A/ADAR/AKT3/NFKBIA/HLA-DPA1/IFNAR1/DNAJB1/EP300/TRADD/HNRNPUL1/EIF2AK2/TRIM25/MAP2K1/IFIH1/IFNGR1/HLA-DPB1/CREBBP/HLA-DRB1/RAB11B/CALCOCO2/PIK3CB/MAPK1/PIK3CA/KPNA6/RAF1/RELA/IRF3/JAK1/NXT1/NFKB1/OAS2/FADD/NFKBIB/MX2/CCL5/OAS3/HLA-DMA/NXF1/IKBKG/HLA-DQB1/HLA-DQA1/NLRX1/CHUK/SOCS3/NXT2/HLA-DMB/JAK2/RNASEL/ICAM1/PIK3CD/HLA-DQA2/TNFRSF10A/TICAM1/PIK3R2/CXCL10/TMPRSS2	5.43356885559339
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	73/1837	216/9376	1.72495413213976	TNFSF10/MAPK3/ABCA1/PIK3R1/PTK2/HSPA1B/FOS/ATF4/CAMK2G/RXRA/VAV3/TNFRSF1A/AKT3/NFKBIA/PDPK1/MAPK8/MAP2K3/XBP1/RAP1B/LDLR/STAT3/ABCG1/LYN/PIK3CB/MAPK1/PIK3CA/VLDLR/RELA/MAPK9/BAD/IRF3/NFE2L2/RXRB/MAP3K7/ATF6/NCF1/PPP3R1/MIB1/NFKB1/HSPA1A/CASP7/PPP3CB/ARHGEF1/TAB2/PPP3CC/MAPK14/NFATC3/CCL5/MAP2K4/CXCL2/IKBKG/OLR1/DDIT3/BCL2L1/MMP9/CHUK/CD36/HSPA6/MAP3K5/RAC1/JUN/TRAF6/JAK2/NCF2/ICAM1/RHOA/PIK3CD/LY96/CD40/TNFRSF10A/TICAM1/PIK3R2/HSP90AA1	5.320751952318
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	43/1837	106/9376	2.07047996631095	MAPK3/CDKN1A/CREB5/EGFR/PIK3R1/PDGFB/IL1R2/ATF4/FOLR1/CREB3L2/AKT3/TCF7L2/NFKBIA/PDPK1/EP300/FGFR1/MAP2K1/RB1/SOS1/FOXO1/CREB3/CREBBP/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/BAD/MDM2/NFKB1/SOS2/MTOR/IKBKG/NKX3-1/ARAF/TCF7L1/MMP9/CHUK/TCF7/PIK3CD/PIK3R2/TMPRSS2/HSP90AA1	5.47110379766667
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	47/1837	120/9376	1.99905643258937	MAPK3/PIK3R1/FOXO3/ARHGDIB/ATF4/CAMK2G/MAGED1/AKT3/NFKBIA/PDPK1/MAPK8/MAP2K1/RAP1B/SOS1/CRK/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/FRS2/BAD/KIDINS220/MAPKAPK2/NFKB1/SOS2/RPS6KA3/CRKL/PSEN1/NFKBIB/MAPK14/GAB1/PRDM4/RPS6KA5/SH2B1/MAP3K5/MAP3K3/RAC1/JUN/TRAF6/MAP2K5/RHOA/PIK3CD/PIK3R2/TP73/MATK	5.43691214347064
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	57/1837	156/9376	1.86491352958419	MAPK3/PPP2CB/CLDN19/CDKN1A/EGFR/PIK3R1/SCARB1/STAT1/RXRA/TNFRSF1A/AKT3/YWHAG/NFKBIA/IFNAR1/TRADD/CFLAR/EIF2AK2/CLDN4/MAP2K1/LDLR/RB1/SOS1/STAT3/PIK3CB/MAPK1/PIK3CA/PPP2CA/RAF1/RELA/BAD/IRF3/JAK1/PPARA/NFKB1/SOS2/PPP2R2D/OAS2/FADD/RIPK1/MX2/OAS3/PIAS1/IKBKG/ARAF/CHUK/SOCS3/CLDN9/TRAF6/CLDN23/RNASEL/CLDN14/CLDN8/PIK3CD/TICAM1/PIK3R2/CXCL10/CLDN15	5.37715894430291
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	32/1837	70/9376	2.33324519791586	PRKAG2/POMC/RXRA/ACSL3/TNFRSF1A/AKT3/NFKBIA/ACSL5/IRS2/TRADD/MAPK8/CPT1A/ADIPOR1/STAT3/APPL1/RELA/MAPK9/RXRB/ACSL4/PPARA/NFKB1/STK11/CAMKK2/NFKBIB/MTOR/IKBKG/CHUK/CD36/SOCS3/JAK2/ACACB/CPT1B	5.52663608996073
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	40/1837	98/9376	2.0832546409963	MAPK3/ASAP3/PIK3R1/VAV3/MARCKSL1/MARCKS/AKT3/GSN/MAP2K1/DNM2/INPPL1/VASP/LYN/ARPC2/CRK/PIK3CB/MAPK1/WASF2/PIK3CA/RAF1/RPS6KB2/NCF1/ARPC1B/LIMK1/CRKL/RPS6KB1/SCIN/SPHK1/PLD1/FCGR3A/RAC1/PRKCE/PIK3CD/PIK3R2/WASF1/ASAP2/ACTR3C/PLA2G6/PIP5K1B/PRKCG	5.32107961308407
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	69/1837	205/9376	1.71792291248988	TAPBP/GADD45B/CDKN1A/PIK3R1/HLA-B/HLA-DRA/STAT1/CIR1/TAPBPL/AKT3/NFKBIA/HLA-DPA1/IFNAR1/GADD45A/TRADD/MAPK8/MAP2K3/RBPJ/EIF2AK2/HLA-DPB1/RB1/STAT3/NCOR2/HLA-DRB1/LYN/PIK3CB/ENTPD1/PIK3CA/RELA/MAPK9/IRF3/MAP3K7/JAK1/MDM2/HLA-E/NFKB1/SAP30L/NFKB2/TNFAIP3/OAS2/FADD/TAB2/NFKBIB/RIPK1/PSMD8/MAPK14/B2M/MAP2K4/OAS3/HLA-DMA/IKBKG/BCL2L11/HLA-DQB1/HLA-DQA1/CHUK/HLA-DMB/RAC1/JUN/TRAF6/RELB/ENTPD8/ICAM1/ISG15/PIK3CD/HLA-DQA2/CD40/PIK3R2/CXCL10/HLA-F	5.13014620764765
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	40/1837	99/9376	2.06221166482462	MAPK3/CDKN1A/EGFR/PIK3R1/PTK2/FOS/NCOA3/ADCY7/AKT3/MAPK8/NOTCH2/NCOR1/MAP2K1/CARM1/RB1/SOS1/PIK3CB/MAPK1/PIK3CA/RAF1/MAPK9/BAD/RPS6KB2/MDM2/SP1/MED1/SOS2/RPS6KB1/MAPK14/MTOR/PRKACA/ARAF/MMP9/GNAS/JUN/PIK3CD/HBEGF/PIK3R2/ADCY9/ESR2	5.24454999840226
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	56/1837	157/9376	1.82052571174963	SERPINE1/MAPK3/GADD45B/SQSTM1/CDKN1A/RHEB/PIK3R1/HLA-B/HIPK3/ZFP36L1/CAPN2/TGFB2/FOXO3/TGFBR1/IGFBP3/ITPR2/AKT3/RAD50/GADD45A/MAP2K3/RBL2/SMAD3/SMAD2/MAP2K1/RB1/FOXO1/HIPK1/FBXW11/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/TGFBR2/RRAS2/MDM2/ZFP36L2/HLA-E/PPP3R1/MAPKAPK2/NFKB1/PPP3CB/PPP3CC/MAPK14/MTOR/NFATC3/BTRC/TSC2/SIRT1/CDKN2B/MRAS/HIPK2/LIN52/PIK3CD/PIK3R2/HLA-F	5.11780174377862
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	41/1837	103/9376	2.03167891930173	SERPINE1/MAPK3/IFNGR2/PPP2CB/GNAQ/PIK3R1/TGFB2/TGFBR1/FOS/TNFRSF1A/AKT3/NFKBIA/MAPK8/CFLAR/SMAD2/IFNGR1/GNAI2/GNA11/PIK3CB/MAPK1/PIK3CA/PPP2CA/RELA/MAPK9/TGFBR2/NFKB1/PPP2R2D/FADD/MAPK14/CCL5/MAP2K4/IKBKG/GNAL/CHUK/GNAS/JUN/TRAF6/PIK3CD/TICAM1/PIK3R2/GNA15	5.19680455257013
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	62/1837	180/9376	1.75803544426299	TAPBP/BST2/IFNGR2/RHEB/PIK3R1/HLA-B/HLA-DRA/STAT1/TNFRSF1A/TAPBPL/AKT3/NFKBIA/HLA-DPA1/CD74/IFNAR1/SP100/TRADD/SRPK1/EIF2AK2/IFIH1/IFNGR1/HLA-DPB1/HLA-DRB1/PIK3CB/PIK3CA/RELA/BAD/IRF3/MAP3K7/JAK1/HLA-E/NFKB1/EIF2B1/OAS2/FADD/DAXX/TAB2/B2M/MTOR/CCL5/OAS3/HLA-DMA/NXF1/IKBKG/BCL2L1/TSC2/HLA-DQB1/HLA-DQA1/HCFC2/CHUK/SOCS3/HLA-DMB/ITGA5/TRAF6/JAK2/RNASEL/PIK3CD/HLA-DQA2/TNFRSF14/TICAM1/PIK3R2/HLA-F	5.06885220908675
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	68/1837	204/9376	1.70132462348031	MAPK3/CDKN1A/EGFR/PIK3R1/PTK2/CAV2/TIMP3/TGFB2/HSPG2/ITGB1/IGF2/FN1/TIAM1/CD63/CAMK2G/VAV3/ITPR2/AKT3/PDPK1/FGFR1/ERBB3/SMAD2/MAP2K1/CBL/PDCD4/SOS1/STAT3/SDC4/PIK3CB/MAPK1/PIK3CA/RAF1/FRS2/RPS6KB2/RRAS2/MDM2/NUDT16L1/SOS2/EIF4B/ARHGEF12/ARHGEF1/IQGAP1/RPS6KB1/PPP1R12B/MET/MAPK14/MTOR/GAB1/PRKACA/ITGA2/ARAF/MMP9/RAC1/ITGA5/WNT2B/MRAS/RHOA/PIK3CD/HBEGF/FZD8/PIK3R2/WNT6/EZR/WNT9A/WNT5B/FZD9/PRKCG/FZD10	4.9990271174544
NA	NA	hsa03272	Virion - Hepatitis viruses	24/1837	48/9376	2.55198693522047	LAMP2/CLDN19/CD9/EGFR/LAMP1/SCARB1/HSPG2/CD63/IST1/TGOLN2/PDCD6IP/CHMP1A/CLDN4/VPS4B/LDLR/TSG101/VPS4A/CHMP1B/DPP4/CLDN9/CLDN23/CLDN14/CLDN8/CLDN15	5.3210550947873
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	50/1837	139/9376	1.83596182389962	MAPK3/CREB5/EGFR/GNAQ/PIK3R1/NCOA1/POMC/HSPA1B/FOS/KRT19/NCOA3/KRT10/ADCY7/ATF4/ITPR2/CREB3L2/AKT3/CTSD/MAP2K1/GNAI2/SOS1/CREB3/KRT18/PIK3CB/MAPK1/PIK3CA/RAF1/KRT15/KRT14/SP1/HSPA1A/SOS2/RARA/ATF6B/NCOA2/ATF2/EBAG9/PRKACA/MMP9/HSPA6/GNAS/JUN/PIK3CD/HBEGF/KRT13/PIK3R2/ADCY9/KRT17/ESR2/HSP90AA1	4.90130487682782
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	74/1837	232/9376	1.62799166557168	MAPK3/SSH2/GNG12/EGFR/PIK3R1/PTK2/PDGFB/ITGB1/FN1/TIAM1/RGCC/VAV3/PAK2/AKT3/GSN/FGFR1/CHRM5/WASL/MAP2K1/SOS1/NCKAP1/GIT1/LPAR2/ARHGEF7/BCAR1/GNA13/ARPC2/CRK/DIAPH1/PIK3CB/MAPK1/WASF2/PIK3CA/RAF1/RRAS2/ITGA3/BRK1/ARPC1B/SSH3/SOS2/APC/LIMK1/CRKL/DIAPH2/ARHGEF12/CXCR4/ARHGEF1/IQGAP1/PIP4K2C/PPP1R12B/SCIN/ITGB4/ITGA2/ARAF/ITGB6/BAIAP2/ITGAD/RAC1/ITGA5/ITGB2/PIP4K2A/MRAS/FGF1/ARHGEF4/RHOA/PIK3CD/PIK3R2/WASF1/MYL2/ACTR3C/ITGAM/EZR/PIP5K1B/C8G	4.78093796400247
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	18/1837	32/9376	2.87098530212303	GABARAPL2/PPP2CB/GABARAP/GABARAPL1/WIPI1/BECN1/ATG5/PPP2CA/ATG13/ATG12/MTOR/ULK2/PIK3C3/ATG2B/ATG4D/ATG16L1/ATG9B/RPTOR	5.23313929401277
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	35/1837	86/9376	2.07719866820271	MAPK3/CDKN1A/EGFR/PIK3R1/PTK2/CAMK2G/PAK2/AKT3/ERBB3/MAPK8/MAP2K1/CBL/SOS1/CRK/PIK3CB/MAPK1/PIK3CA/RAF1/MAPK9/BAD/RPS6KB2/SOS2/CRKL/RPS6KB1/MTOR/MAP2K4/GAB1/ABL2/ARAF/JUN/PIK3CD/HBEGF/PIK3R2/EREG/PRKCG	4.95359528305632
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	54/1837	155/9376	1.77815863873426	TUBB2A/LAMP2/DYNC1LI2/RAB5A/LAMP1/ATP6V0D1/HLA-B/HLA-DRA/SCARB1/ATP6V0E1/ITGB1/ATP6AP1/HLA-DPA1/MRC2/DYNC1H1/ATP6V1G1/HLA-DPB1/STX7/ATP6V1B2/HLA-DRB1/ATP6V1D/RAB5B/RAB7A/HGS/ATP6V1E1/STX12/HLA-E/NCF1/CTSS/STX18/ATP6V1C1/ATP6V0B/ATP6V0A1/PIK3C3/HLA-DMA/OLR1/ITGA2/HLA-DQB1/HLA-DQA1/MSR1/CD36/FCGR3A/HLA-DMB/RAC1/ITGA5/ITGB2/THBS3/NCF2/ATP6V1E2/HLA-DQA2/TUBA4A/SEC61G/HLA-F/ITGAM	4.82201243397931
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	34/1837	83/9376	2.09078447704809	JARID2/PHC2/UBE2D1/USP16/EP300/BMI1/SUZ12/CREBBP/MAX/KDM2A/LCOR/PHF1/DCAF7/FOXK2/ASXL1/L3MBTL3/UBE2D2/ASXL2/YY1/MGA/BCORL1/RING1/UBE2D3/YAF2/UBE2D4/FBRS/PCGF2/PCGF1/MBD6/BCOR/BAP1/SKP1/SCMH1/CBX7	4.92700917689684
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	43/1837	115/9376	1.90844240373009	MAPK3/CDKN1A/CREB5/EGFR/GNAQ/JUND/FOS/WNK1/ADCY7/ATF4/RXRA/ITPR2/CREB3L2/GATA3/EGR1/FGFR1/AKAP13/MAP2K1/GNAI2/SGK1/GNA11/CREB3/GNA13/MAPK1/RAF1/RXRB/SP1/ATF6B/WNK2/ATF2/ARHGEF1/PRKACA/PDE4C/ARAF/PLD1/GNAS/PDE4A/RHOA/HBEGF/ADCY9/ARHGEF11/SLC12A3/PRKCG	4.83838831379695
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	47/1837	130/9376	1.84528286085172	MAPK3/CREB5/GNG12/EGFR/PIK3R1/TGFBR1/FOS/ADCY7/ATF4/CREB3L2/AKT3/NFKBIA/MAPK8/VEGFB/EDNRB/SMAD2/MAP2K1/GNAI2/SOS1/CREB3/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/TGFBR2/GNB1/NFKB1/SOS2/COL4A2/ATF6B/ATF2/MAPK14/MAP2K4/GNG10/PRKACA/GNB5/COL4A1/MMP9/GNAS/JUN/PIK3CD/PIK3R2/EDN1/ADCY9/GNA15	4.79049222356813
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	39/1837	101/9376	1.9708413955168	SERPINE1/MAPK3/PIM1/PIK3R1/PLCD3/TGFB2/TGFBR1/FN1/STAT1/AKT3/EGR1/SMAD4/MAPK8/VEGFB/SMAD3/SMAD2/FOXO1/STAT3/DIAPH1/PIK3CB/MAPK1/PIK3CA/RELA/MAPK9/TGFBR2/NFKB1/COL4A2/MAPK14/COL4A1/RAC1/JUN/JAK2/PRKCE/AGTR1/ICAM1/PIK3CD/PIK3R2/EDN1/NOX4	4.84211788317964
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	60/1837	181/9376	1.69192503992517	MAPK3/LAMP2/IFNGR2/RAB5A/LAMP1/ATP6V0D1/HLA-DRA/TGFB2/STAT1/ATP6AP1/CAMK2G/TNFRSF1A/AKT3/HLA-DPA1/CTSD/CD74/EP300/PLK3/TRADD/MAPK8/MRC2/IFNGR1/HLA-DPB1/IL10RB/CREBBP/HLA-DRB1/RAB5B/MAPK1/CEBPB/RAB7A/RAF1/RELA/MAPK9/BAD/JAK1/CTSS/PPP3R1/KSR1/ATP6V0B/NFKB1/ARHGEF12/PPP3CB/FADD/ATP6V0A1/PPP3CC/MAPK14/PIK3C3/HLA-DMA/SPHK1/HLA-DQB1/HLA-DQA1/FCGR3A/HLA-DMB/ITGB2/TRAF6/LSP1/JAK2/RHOA/HLA-DQA2/ITGAM	4.63987000181399
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	45/1837	125/9376	1.83743059335874	MAPK3/PPP2CB/GNAQ/PIK3R1/PPP2R5E/SGMS2/ASAH1/TNFRSF1A/AKT3/PDPK1/CTSD/TRADD/MAPK8/MAP2K1/GNAI2/ORMDL1/SGPP1/GNA13/PIK3CB/MAPK1/PIK3CA/PPP2CA/RAF1/RELA/MAPK9/SPTLC2/NFKB1/PPP2R5A/ORMDL3/PPP2R2D/PPP2R3C/MAPK14/SMPD1/SPHK1/PLD1/MAP3K5/RAC1/PRKCE/PPP2R5B/SPTLC3/ACER2/RHOA/PIK3CD/PIK3R2/PRKCG	4.65256911495298
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	36/1837	93/9376	1.97573182081585	GADD45B/CDKN1A/PIK3R1/PTK2/ITGB1/FN1/RXRA/AKT3/NFKBIA/LAMA5/XIAP/GADD45A/LAMC1/RB1/MAX/PIK3CB/PIK3CA/RELA/RXRB/BIRC7/ITGA3/NFKB1/COL4A2/LAMA3/LAMB2/IKBKG/ITGA2/BCL2L1/COL4A1/LAMC2/CHUK/TRAF6/LAMB3/CDKN2B/PIK3CD/PIK3R2	4.66778788293052
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	39/1837	105/9376	1.89576172330663	MAPK3/PIK3R1/BCL3/STAT1/ITPR2/IRF1/AKT3/NFKBIA/PLK3/MAPK8/IL17D/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/RRAS2/MDM2/PPP3R1/KSR1/MAPKAPK2/NFKB1/NFKB2/ARHGEF12/PPP3CB/PPP3CC/MAPK14/NFATC3/IKBKG/CYLD/CHUK/JUN/RELB/LSP1/MRAS/RHOA/PIK3CD/PIK3R2	4.5562464198734
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	35/1837	91/9376	1.96306687324651	MAPK3/PIK3R1/DAPP1/FOS/VAV3/AKT3/NFKBIA/MAP2K1/SOS1/INPPL1/LYN/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/CD22/PPP3R1/NFKB1/SOS2/PPP3CB/PPP3CC/NFKBIB/NFATC3/IKBKG/CHUK/RAC1/JUN/PIK3AP1/PIK3CD/CD72/PIK3R2/LILRB4/LILRB3/BANK1	4.55690034876325
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	37/1837	99/9376	1.90754578996277	MAPK3/LYPLA1/RHEB/EGFR/PIK3R1/PDGFB/FOS/AKT3/PDPK1/MAPK8/MAP2K1/SOS1/PIK3CB/MAPK1/WASF2/PIK3CA/RAF1/MAPK9/RPS6KB2/SP1/SOS2/RALGDS/RPS6KB1/MTOR/GPCPD1/TSC2/PLD1/CHKB/DGKA/RAC1/JUN/PIK3CD/SLC22A4/PIK3R2/WASF1/PIP5K1B/PRKCG	4.48090472823521
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	38/1837	103/9376	1.88301948618209	RAB5A/GNAQ/PIK3R1/SERPINB6/PTK2/IL1R1/TGFB2/HSPB1/FN1/IL1R2/LAMA5/LAMC1/GNA11/RAB5B/PIK3CB/PIK3CA/RAB7A/RELA/NFKB1/COL4A2/PRDX1/LAMA3/PRKACA/LAMB2/CXCL2/GNAL/COL4A1/LAMC2/GNAS/ITGB2/LAMB3/PIK3CD/PIK3R2/ITGAM/SERPINB4/GNA15/PRKCG/C8G	4.44797271703983
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	31/1837	78/9376	2.02850243568806	PIK3R1/CLTB/PTK2/CAV2/ITGB1/FN1/CLTC/WASL/MAD2L2/CBL/DNM2/BCAR1/ARPC2/CRK/PIK3CB/WASF2/PIK3CA/ARHGAP10/ARPC1B/CRKL/MET/GAB1/RAC1/ITGA5/ELMO3/RHOA/PIK3CD/ELMO2/PIK3R2/WASF1/ACTR3C	4.50237018297818
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	17/1837	33/9376	2.62931987265139	SNAP23/VAMP8/VAMP2/STX4/STX5/SNAP29/VAMP7/STX7/STX16/GOSR1/STX3/STX18/STX11/BET1L/STX17/VAMP4/STX1A	4.62810810499022
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	26/1837	62/9376	2.14037613921717	PRKAG2/EIF4EBP2/PIK3R1/FOXO3/HSPA1B/ADCY7/AKT3/IRS2/FOXO1/PIK3CB/ATG5/PIK3CA/RPS6KB2/SOD1/HSPA1A/AKT1S1/RPS6KB1/CRYAB/MTOR/PRKACA/SIRT1/HSPA6/RPTOR/PIK3CD/PIK3R2/ADCY9	4.44691874876718
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	39/1837	109/9376	1.8261924857541	PRKAG2/CREB5/GFPT1/PIK3R1/MLXIP/PTPRF/TNFRSF1A/CREB3L2/AKT3/NFKBIA/PDPK1/SLC27A1/IRS2/MAPK8/CPT1A/FOXO1/STAT3/CREB3/PIK3CB/PIK3CA/RELA/MAPK9/NR1H2/RPS6KB2/PPARA/NFKB1/RPS6KA3/RPS6KB1/MTOR/PPP1R3D/TBC1D4/PYGB/CD36/SOCS3/PRKCE/PIK3CD/ACACB/PIK3R2/CPT1B	4.28260729945636
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	101/1837	362/9376	1.42403690860369	SPP1/MAPK3/IL2RB/PPP2CB/CDKN1A/CREB5/GNG12/RHEB/EGFR/PKN1/PIK3R1/PTK2/FOXO3/PDGFB/CSH1/FLT1/ITGB1/IGF2/FN1/PPP2R5E/ATF4/RXRA/CREB3L2/AKT3/YWHAG/PDPK1/LAMA5/IFNAR1/FGFR1/ERBB3/LAMC1/VEGFB/RBL2/MAP2K1/SGK1/SOS1/LPAR2/CREB3/CSH2/PIK3CB/MAPK1/PIK3CA/PPP2CA/RAF1/RELA/CSF1R/BAD/IL4R/RPS6KB2/JAK1/OSMR/MDM2/GNB1/ITGA3/NFKB1/PPP2R5A/SOS2/COL4A2/EIF4B/PPP2R2D/STK11/ATF6B/MCL1/ATF2/PPP2R3C/EPOR/RPS6KB1/MET/MTOR/LAMA3/ITGB4/GNG10/LAMB2/GNB5/IKBKG/BCL2L11/ITGA2/BCL2L1/COL4A1/ITGB6/TSC2/LAMC2/CHUK/RAC1/ITGA5/JAK2/THBS3/PIK3AP1/LAMB3/EFNA1/PPP2R5B/RPTOR/FGF1/PIK3CD/CSHL1/PIK3R2/EREG/ANGPT2/SGK3/IL2RG/HSP90AA1	4.06146310856655
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	39/1837	110/9376	1.8095907358836	FBN1/NOG/LTBP1/MAPK3/BMPR2/PPP2CB/TGFB2/BAMBI/TGFBR1/SKIL/EP300/SMAD4/SMAD3/SMAD2/NCOR1/TGIF1/CREBBP/MAPK1/PPP2CA/RPS6KB2/TGFBR2/SP1/ACVR2B/BMPR1B/RGMB/SMURF1/LEMD3/RPS6KB1/SMURF2/SKP1/HAMP/CDKN2B/ACVR1B/ID1/RHOA/SMAD7/HFE/THSD4/INHBA	4.21598511857474
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	63/1837	205/9376	1.5685383114038	MAPK3/IL6ST/CDKN1A/CREB5/DDB1/ATP6V0D1/PIK3R1/HLA-B/ATF4/CREB3L2/YWHAG/NFKBIA/GSN/SP100/EP300/TRADD/CHD4/RBPJ/RBL2/EIF2AK2/REL/RB1/STAT3/CREB3/GTF2E2/CREBBP/UBR4/LYN/UBE3A/PIK3CB/MAPK1/PIK3CA/RELA/BAD/VAC14/IRF3/GTF2A1/JAK1/HDAC5/LTBR/MDM2/HLA-E/GTF2B/MAPKAPK2/NFKB1/NFKB2/ATF6B/ATF2/SCIN/GTF2H1/POLB/PRKACA/TBP/IKBKG/HDAC7/RAC1/JUN/CDKN2B/KAT2B/RHOA/PIK3CD/PIK3R2/HLA-F	4.06267109101597
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	28/1837	71/9376	2.01283476580769	MAPK3/PIK3R1/FOXO3/FOS/STAT1/IRF1/AKT3/SOCS1/MAPK8/MAP2K1/SOS1/STAT3/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/NFKB1/SOS2/MAPK14/SOCS4/SOCS3/JAK2/SOCS5/PIK3CD/PIK3R2/ESR2	4.22856421834246
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	46/1837	138/9376	1.70132462348031	PRKAG2/MAPK3/RHEB/PIK3R1/PTPRF/TRIP10/AKT3/PDPK1/IRS2/PRKAR2A/FLOT2/SOCS1/FLOT1/MAPK8/PHKB/MAP2K1/CBL/SOS1/FOXO1/INPPL1/CRK/PIK3CB/MAPK1/PIK3CA/RAF1/MAPK9/BAD/PRKAR1A/RPS6KB2/PRKCI/SOS2/CRKL/RPS6KB1/MTOR/PPP1R3D/PRKACA/SOCS4/PYGB/ARAF/TSC2/SOCS3/FBP1/RPTOR/PIK3CD/ACACB/PIK3R2	4.09687766777404
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	54/1837	170/9376	1.62126228825771	PRKAG2/TJP1/PPP2CB/CLDN19/JAM2/AMOTL2/TJP2/LLGL2/ITGB1/TIAM1/MAPK8/CLDN4/VASP/ARHGEF2/ARPC2/PARD3/PPP2CA/MAPK9/AMOTL1/RAPGEF2/RAB8B/F11R/SYMPK/AMOT/YBX3/RUNX1/PRKCI/ARPC1B/PARD6B/MICALL2/PPP2R2D/STK11/PRKACA/SYNPO/MAP3K5/PARD6G/NF2/TJAP1/RAC1/JUN/ARHGEF18/CLDN9/CLDN23/PRKCE/CGNL1/CLDN14/RHOA/CLDN8/TUBA4A/NEDD4L/MYL2/CLDN15/ACTR3C/EZR	4.03503505486203
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	56/1837	178/9376	1.60574458845333	SFRP1/BAMBI/TLE6/NOTUM/CAMK2G/CTBP2/CSNK2A2/TCF7L2/ANKRD6/EP300/SMAD4/MAPK8/TBL1XR1/SMAD3/DAAM1/CSNK1A1/TLE2/CTNND2/DVL1/CREBBP/GPC4/FBXW11/TLE3/RYK/MAPK9/MAP3K7/PPP3R1/APC/PPP3CB/PORCN/PSEN1/PPP3CC/FRAT1/NFATC3/PRKACA/BTRC/SIRT1/SKP1/TCF7L1/CELSR1/RAC1/JUN/TCF7/WNT2B/ROR1/RHOA/FZD8/CELSR2/MMP7/WNT6/WNT9A/WNT5B/FZD9/CELSR3/PRKCG/FZD10	4.02750590831555
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	22/1837	51/9376	2.20171421862158	TJP1/ATP6V0D1/KDELR3/TJP2/ATP6V0E1/ATP6AP1/ATP6V1G1/ATP6V1B2/ATP6V1D/KDELR2/ATP6V1E1/ARF1/ATP6V1C1/ATP6V0B/KDELR1/ATP6V0A1/PRKACA/SLC12A2/GNAS/ATP6V1E2/SEC61G/ADCY9	4.24761565003038
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	62/1837	203/9376	1.55884916240068	SPP1/MAPK3/EGFR/PIK3R1/PTK2/CAV2/CAPN2/PDGFB/FLT1/ITGB1/FN1/VAV3/PAK2/AKT3/PDPK1/LAMA5/XIAP/LAMC1/MAPK8/VEGFB/PARVA/FLNB/MAP2K1/RAP1B/SOS1/VASP/BCAR1/CRK/DIAPH1/PIK3CB/MAPK1/PIK3CA/RAF1/MAPK9/BAD/TLN2/ITGA3/SOS2/COL4A2/CRKL/PPP1R12B/MET/LAMA3/ITGB4/LAMB2/ITGA2/COL4A1/ITGB6/LAMC2/RAC1/ITGA5/JUN/THBS3/LAMB3/RHOA/PIK3CD/RASGRF1/PIK3R2/MYL2/PARVG/PIP5K1B/PRKCG	3.97347304524385
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	38/1837	109/9376	1.77936703740143	SPP1/MAPK3/PIK3R1/FOS/STAT1/AKT3/NFKBIA/IFNAR1/MAPK8/MAP2K3/MAP2K1/PIK3CB/MAPK1/PIK3CA/RELA/MAPK9/IRF3/MAP3K7/JAK1/NFKB1/FADD/TAB2/RIPK1/MAPK14/CCL5/MAP2K4/IKBKG/CHUK/RAC1/JUN/TRAF6/PIK3CD/LY96/CD40/TICAM1/PIK3R2/CXCL9/CXCL10	4.0398854030784
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	25/1837	62/9376	2.05805398001651	TLE6/ATXN1/CTBP2/CIR1/NCSTN/EP300/DTX4/MAML2/NOTCH2/RBPJ/TLE2/DTX3L/DVL1/CREBBP/SPEN/NCOR2/TLE3/ITCH/APH1B/PSEN1/MAML1/ATXN1L/KAT2B/LFNG/NRARP	4.12590190125605
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	53/1837	168/9376	1.61018223293672	IL6ST/CSF2RB/IL2RB/IFNGR2/PIM1/CDKN1A/EGFR/PIK3R1/PDGFB/CSH1/STAT1/CSF2RA/IL13RA1/AKT3/IFNAR1/EP300/SOCS1/STAT4/IFNGR1/SOS1/STAT3/STAM/IL10RB/CREBBP/CSH2/PIK3CB/PIK3CA/RAF1/IL4R/JAK1/OSMR/SOS2/STAT6/FHL1/MCL1/IL27RA/EPOR/MTOR/PIAS1/SOCS4/BCL2L1/SOCS3/CLCF1/IL27/JAK2/SOCS5/PIAS3/PIK3CD/IL11/CSHL1/PIK3R2/CTF1/IL2RG	3.93926219456424
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	24/1837	59/9376	2.07619276085733	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/FOXO3/AKT3/TCF7L2/PDPK1/GADD45A/MAP2K1/SOS1/PIK3CB/MAPK1/PIK3CA/RAF1/BAD/SOS2/APC/ARAF/TCF7L1/TCF7/PIK3CD/PIK3R2	4.09318495502609
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	41/1837	122/9376	1.71526990727933	MED13L/MAPK3/RHEB/PIK3R1/PLCD3/NCOA1/NCOA3/STAT1/RXRA/AKT3/PDPK1/EP300/MED13/NOTCH2/NCOR1/MAP2K1/MED4/FOXO1/THRB/CREBBP/PIK3CB/MAPK1/PIK3CA/RAF1/BAD/RXRB/MDM2/MED1/ATP1A4/NCOA2/MTOR/PRKACA/TBC1D4/RCAN1/TSC2/MED14/KAT2B/PIK3CD/PIK3R2/PRKCG/PFKFB2	3.92526034013669
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	46/1837	142/9376	1.65339998619918	SQSTM1/BMPR2/PIK3R1/PTK2/CAV2/IL1R1/DUSP1/PDGFB/FOS/IL1R2/TXN/HMOX1/TNFRSF1A/AKT3/MAPK8/SDC4/ARHGEF2/GSTT1/PIK3CB/PIK3CA/RELA/MAPK9/NFE2L2/MAP3K7/NCF1/NFKB1/ACVR2B/BMPR1B/KLF2/MAPK14/MAP2K4/GSTA3/IKBKG/MMP9/CHUK/MAP3K5/RAC1/JUN/MAP2K5/NCF2/ICAM1/RHOA/PIK3CD/PIK3R2/EDN1/HSP90AA1	3.87268080327825
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	48/1837	150/9376	1.6332716385411	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/TGFB2/TGFBR1/RXRA/AKT3/TCF7L2/GADD45A/SMAD4/SMAD3/SMAD2/MAP2K1/CSNK1A1/RB1/SOS1/DVL1/PIK3CB/MAPK1/PIK3CA/RAF1/RXRB/RPS6KB2/TGFBR2/JUP/SOS2/APC/RPS6KB1/FRAT1/MET/MTOR/GAB1/ARAF/TCF7L1/TCF7/CDKN2B/WNT2B/FGF1/PIK3CD/FZD8/PIK3R2/WNT6/WNT9A/WNT5B/FZD9/FZD10	3.85933330574321
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	39/1837	116/9376	1.71599121506204	ESAM/CLDN19/JAM2/PIK3R1/PTK2/ITGB1/VAV3/CLDN4/RAP1B/GNAI2/VASP/BCAR1/PIK3CB/PIK3CA/PTK2B/SIPA1/F11R/NCF1/CD99L2/CXCR4/MAPK14/MMP9/RAC1/ITGB2/CLDN9/CLDN23/NCF2/ICAM1/CLDN14/RAPGEF3/RHOA/CLDN8/PIK3CD/PIK3R2/MYL2/CLDN15/ITGAM/EZR/PRKCG	3.83013903879433
Human Diseases	Infectious disease: viral	hsa05162	Measles	44/1837	136/9376	1.65128566396619	CD46/IL2RB/PIK3R1/HSPA1B/FOS/STAT1/CSNK2A2/ADAR/AKT3/NFKBIA/IFNAR1/TRADD/MAPK8/EIF2AK2/IFIH1/STAT3/PIK3CB/PIK3CA/RELA/MAPK9/BAD/IRF3/MAP3K7/JAK1/NFKB1/HSPA1A/TNFAIP3/OAS2/FADD/TAB2/NFKBIB/MX2/OAS3/IKBKG/BCL2L1/CHUK/HSPA6/JUN/TRAF6/BBC3/PIK3CD/PIK3R2/TP73/IL2RG	3.77648993795955
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	33/1837	94/9376	1.79182061409097	MAPK3/FOSB/JUND/FOS/MAPK6/NFKBIA/TRADD/MAPK8/IL17D/MAPK1/CEBPB/IL17RE/RELA/MAPK9/MAP3K7/ELAVL1/NFKB1/TNFAIP3/FADD/TAB2/MAPK14/CXCL2/IKBKG/MMP9/CHUK/TAB3/JUN/TRAF6/IL17B/IL17RC/CXCL10/MAPK15/HSP90AA1	3.80849415450065
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	19/1837	44/9376	2.20398871678131	DYNC1LI2/CREB5/RAB5A/ARHGDIB/VAMP2/STX4/CREB3L2/DYNC1H1/DCTN6/CREB3/RAB11B/RAB5B/DCTN2/DCTN1/DCTN4/PRKACA/GNAS/AQP3/ADCY9	3.95134303786171
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	58/1837	193/9376	1.53383670717914	MAPK3/GNG12/GNAQ/PIK3R1/PTK2/FOXO3/TIAM1/STAT1/ADCY7/VAV3/AKT3/XCR1/NFKBIA/GRK4/MAP2K1/RAP1B/GNAI2/SOS1/STAT3/BCAR1/CXCR6/LYN/PARD3/CRK/PIK3CB/MAPK1/PIK3CA/PTK2B/RAF1/RELA/BAD/NCF1/GNB1/GSK3A/NFKB1/SOS2/CRKL/CXCR4/NFKBIB/CCL5/GNG10/PRKACA/GNB5/CXCL2/IKBKG/CHUK/CXCL16/RAC1/JAK2/RHOA/PIK3CD/PIK3R2/CXCL9/CXCL10/ADCY9/CCL28/FGR/DOCK2	3.69894726791731
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	29/1837	80/9376	1.85019052803484	MAPK3/EGFR/PIK3R1/FOXO3/PDGFB/AKT3/ERBB3/MAP2K1/SOS1/STAT3/PIK3CB/MAPK1/PIK3CA/RAF1/BAD/RPS6KB2/JAK1/SOS2/RPS6KB1/MET/MTOR/GAB1/BCL2L11/BCL2L1/ARAF/JAK2/PIK3CD/PIK3R2/PRKCG	3.76961105885588
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	27/1837	73/9376	1.88777115756035	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/FOXO3/RXRA/AKT3/PDPK1/GADD45A/MAP2K1/RB1/SOS1/STAT3/PIK3CB/MAPK1/PIK3CA/RAF1/BAD/RXRB/RASSF1/SOS2/MET/ARAF/PIK3CD/PIK3R2/PRKCG	3.75867084771731
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	25/1837	66/9376	1.93332343577308	IFNGR2/HLA-DRA/TGFB2/STAT1/GATA3/HLA-DPA1/STAT4/SMAD3/SMAD2/IFNGR1/HLA-DPB1/STAT3/HLA-DRB1/RELA/IL4R/NFKB1/STAT6/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/JUN/IL18R1/HLA-DQA2/IL2RG	3.75588808556502
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	48/1837	155/9376	1.58058545665268	MAPK3/CDKN1A/CREB5/EGFR/GNAQ/SCARB1/POMC/ADCY7/ATF4/CAMK2G/ITPR2/CREB3L2/TCF7L2/MAP2K1/RAP1B/LDLR/GNAI2/RB1/DVL1/USP8/GNA11/CREB3/KMT2A/MAPK1/HSD3B1/SP1/APC/ATF6B/ATF2/PRKACA/TCF7L1/ORAI1/GNAS/TCF7/CDKN2B/WNT2B/AGTR1/ARMC5/FZD8/RASD1/WNT6/ADCY9/CRH/WNT9A/CACNA1C/WNT5B/FZD9/FZD10	3.59771150972574
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	32/1837	93/9376	1.75620606294742	MAPK3/TJP1/EGFR/TGFBR1/PTPRF/CSNK2A2/TCF7L2/EP300/FGFR1/SMAD4/WASL/SMAD3/RAP1B/YES1/CREBBP/PARD3/MAPK1/WASF2/MAP3K7/TGFBR2/SNAI1/SMURF1/IQGAP1/MET/SMURF2/BAIAP2/TCF7L1/RAC1/TCF7/RHOA/WASF1/MYL2	3.61760211394269
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	45/1837	144/9376	1.59499183451279	PRKAG2/ACOX1/LPIN2/FOXO3/TNFRSF1A/AKT3/TCF7L2/NFKBIA/TRADD/MAPK8/MAP2K3/CPT1A/ADIPOR1/FOXO1/RELA/MAPK9/IRF3/MAP3K7/PPARA/NFKB1/FADD/CAMKK2/TAB2/RIPK1/C2/MAPK14/MLYCD/MAP2K4/CXCL2/IKBKG/SIRT1/TCF7L1/CHUK/TAB3/MAP3K5/TRAF6/TCF7/ACOX3/LPIN1/IL17RC/LY96/TICAM1/ACACB/NOX4/CPT1B	3.55162985885452
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	28/1837	78/9376	1.83219574836341	PLCD3/IPMK/CDIPT/INPP5B/INPPL1/PI4KA/PIK3CB/PIK3CA/PIK3C2A/IMPA2/MTMR1/PIP4K2C/IP6K1/INPP5F/PI4KB/SACM1L/PIK3C3/PIK3C2B/INPP5K/ITPKC/SYNJ2/OCRL/PIP4K2A/PIP5KL1/ITPK1/PIK3CD/MTM1/PIP5K1B	3.64301842545079
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	39/1837	122/9376	1.63159820448522	MAPK3/PPP2CB/PIK3R1/FOS/PPP2R5E/VAV3/PAK2/AKT3/NFKBIA/PDPK1/MAPK8/MAP2K1/SOS1/PIK3CB/MAPK1/PIK3CA/PPP2CA/RAF1/RELA/MAPK9/MAP3K7/PPP3R1/NFKB1/PPP2R5A/SOS2/PPP2R2D/PPP3CB/PPP2R3C/PPP3CC/NFKBIB/MAPK14/NFATC3/IKBKG/CHUK/JUN/PPP2R5B/RHOA/PIK3CD/PIK3R2	3.46608651886033
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	26/1837	72/9376	1.843101675437	ADAR/NFKBIA/TRADD/MAPK8/TRIM25/IFIH1/ATG5/RELA/MAPK9/IRF3/MAP3K7/ATG12/OTUD5/NFKB1/ZNFX1/FADD/NFKBIB/RIPK1/MAPK14/IKBKG/CYLD/NLRX1/CHUK/TRAF6/ISG15/CXCL10	3.54482413877068
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	18/1837	44/9376	2.08798931063493	HEXB/MAN1A1/MGAT4A/HEXA/MGAT4B/MGAT2/ALG3/FUT8/B4GALT2/MGAT1/B4GALT3/RPN1/MAN2A1/MAGT1/RPN2/ALG1/DDOST/ST3GAL3	3.57064723940111
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	45/1837	148/9376	1.55188394709353	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/NCOA1/FOS/NCOA3/AKT3/TCF7L2/GADD45A/FGFR1/NOTCH2/MAP2K1/CSNK1A1/RB1/SOS1/DVL1/PIK3CB/MAPK1/PIK3CA/RAF1/RPS6KB2/SP1/SOS2/APC/NFKB2/RPS6KB1/FRAT1/MTOR/ARAF/TCF7L1/JUN/TCF7/WNT2B/FGF1/PIK3CD/FZD8/PIK3R2/WNT6/ESR2/WNT9A/WNT5B/FZD9/FZD10	3.34047457953154
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	44/1837	144/9376	1.55954757152362	KLF4/MAPK3/IL6ST/BMPR2/PIK3R1/ZFHX3/JARID2/AKT3/SKIL/FGFR1/BMI1/SMAD4/KAT6A/SMAD3/SMAD2/MAP2K1/STAT3/DVL1/PIK3CB/MAPK1/PIK3CA/RAF1/JAK1/APC/ACVR2B/BMPR1B/MAPK14/PCGF2/PCGF1/TCF7/JAK2/WNT2B/ACVR1B/ID1/PIK3CD/FZD8/ESX1/PIK3R2/WNT6/WNT9A/WNT5B/FZD9/FZD10/INHBA	3.34005569017619
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	47/1837	157/9376	1.5279412223613	MAPK3/ABCA1/RAB5A/PTK2/CAMK2G/RXRA/ANO6/ADAM10/GULP1/LRP1/RAB14/MAP2K1/CPT1A/SGK1/TMEM30A/BCAR1/ADAM9/RAB5B/CRK/MAPK1/CEBPB/RAB7A/NR1H2/DUSP4/MAPKAPK2/CRKL/CASP7/EPOR/MAPK14/NFATC3/STAB2/VPS39/SPHK1/TGFBRAP1/SIRT1/DUSP7/CD36/VPS11/RAC1/P2RY6/JAK2/PTGER4/HAVCR2/PLA2G6/ALOX5/CPT1B/P2RY2	3.29288707193822
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	47/1837	157/9376	1.5279412223613	SERPINE1/BMPR2/PPP2CB/TGFB2/TEAD1/LLGL2/TGFBR1/WWTR1/TCF7L2/YWHAG/SMAD4/SMAD3/SMAD2/STK3/DVL1/FBXW11/PARD3/PPP2CA/TGFBR2/LATS1/AMOT/PRKCI/RASSF1/PARD6B/APC/PPP2R2D/SAV1/BMPR1B/BTRC/TCF7L1/PARD6G/NF2/ITGB2/TCF7/BBC3/WNT2B/ID1/FGF1/SMAD7/FZD8/WNT6/AJUBA/TP73/WNT9A/WNT5B/FZD9/FZD10	3.29288707193822
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	34/1837	105/9376	1.65271534852373	GADD45B/IL1R1/TNFRSF1A/CSNK2A2/NFKBIA/XIAP/GADD45A/TRADD/PPP1R13L/CFLAR/TRIM25/LYN/RELA/MAP3K7/LTBR/NFKB1/NFKB2/TNFAIP3/TAB2/RIPK1/CXCL2/IKBKG/CYLD/BCL2L1/CHUK/TAB3/TRAF6/RELB/ICAM1/LY96/CD40/TICAM1/EDA2R/CARD14	3.32000340328189
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	54/1837	187/9376	1.47387480750701	MAPK3/GABARAPL2/MAP1LC3B/PKN1/GABARAP/STAT1/TXN/CTSB/ITPR2/NFKBIA/IFNAR1/XIAP/MAPK8/GABARAPL1/NEK7/RBCK1/MAPK1/ATG5/RELA/MAPK9/IRF3/MAP3K7/JAK1/ATG12/GBP3/NFKB1/TNFAIP3/MFN1/ANTXR1/OAS2/FADD/TAB2/NFKBIB/RIPK1/MAPK14/TP53BP1/CCL5/OAS3/MFN2/CXCL2/IKBKG/BCL2L1/NLRX1/CHUK/TAB3/JUN/TRAF6/ATG16L1/NLRP7/RNASEL/RHOA/P2RX7/TICAM1/HSP90AA1	3.23097533916127
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/1837	56/9376	1.91399020141535	MGAT5/MAN1A1/MGAT4A/DHRSX/MGAT4B/MGAT2/ALG3/FUT8/B4GALT2/ALG5/MGAT1/DPM2/B4GALT3/RPN1/MAN2A1/MAGT1/RPN2/ALG8/ALG1/DDOST/DOLK	3.38618702952163
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	14/1837	32/9376	2.23298856831791	TNFRSF1A/XIAP/MAPK8/BECN1/BIRC6/MAPK9/BIRC7/CASP7/FADD/BOK/BCL2L11/BCL2L1/BBC3/DIABLO	3.44866467877187
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	27/1837	79/9376	1.74439613293551	SLC6A2/ATP6V0D1/CLTB/ATP6V0E1/VAMP2/CLTC/SLC1A3/AP2B1/AP2A2/SLC17A8/ATP6V1G1/NAPA/DNM2/ATP6V1B2/ATP6V1D/ATP6V1E1/STX3/ATP6V1C1/ATP6V0B/ATP6V0A1/SLC6A4/SLC1A6/STXBP1/CACNA1A/ATP6V1E2/STX1A/RAB3A	3.27966574051899
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	18/1837	47/9376	1.95471339719015	MAPK3/PIK3R1/IRS2/SOCS1/MAPK8/PIK3CB/MAPK1/PIK3CA/MAPK9/MTOR/SOCS4/SOCS3/PRKCE/CACNA1A/PIK3CD/MAFA/PIK3R2/CACNA1C	3.23882694779846
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	28/1837	85/9376	1.68130903967466	CMPK1/UPP1/NME3/NT5E/UCK2/ENTPD4/DCTD/DGUOK/NME4/CANT1/ENTPD1/CDA/NME6/TK2/GDA/GMPR2/RRM2B/AMPD2/NT5C2/HPRT1/AK5/AMPD3/LACC1/ENTPD5/GUK1/ENTPD8/CMPK2/AK9	3.11462473858513
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	31/1837	98/9376	1.61452234677213	PIK3R1/PLCD3/ITPR2/IPMK/CDIPT/INPP5B/INPPL1/PI4KA/PIK3CB/PIK3CA/PIK3C2A/IMPA2/MTMR1/PIP4K2C/IP6K1/INPP5F/PI4KB/SACM1L/PIK3C3/PIK3C2B/ITPKC/SYNJ2/OCRL/DGKA/PIP4K2A/ITPK1/PIK3CD/MTM1/PIK3R2/PIP5K1B/PRKCG	3.01860911316875
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	9/1837	18/9376	2.55198693522047	HEXB/AGA/HEXA/GLB1/FUCA2/MAN2B2/NEU1/FUCA1/ENGASE	3.25324025711264
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	21/1837	60/9376	1.78639085465433	MAPK3/PIK3R1/PTK2/HSPB1/AKT3/MAP2K1/PIK3CB/MAPK1/PIK3CA/RAF1/BAD/PPP3R1/MAPKAPK2/PPP3CB/PPP3CC/MAPK14/SPHK1/RAC1/PIK3CD/PIK3R2/PRKCG	3.0163566051306
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	8/1837	15/9376	2.7221193975685	HEXB/ST3GAL5/HEXA/GLB1/B3GALT4/ST8SIA1/ST6GALNAC6/ST3GAL2	3.29481557412887
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/1837	69/9376	1.70132462348031	MAPK3/PIK3R1/VAV3/AKT3/PDPK1/MAPK8/MAP2K3/MAP2K1/SOS1/LYN/PIK3CB/MAPK1/PIK3CA/RAF1/MAPK9/SOS2/MAPK14/MAP2K4/RAC1/ALOX5AP/PIK3CD/PIK3R2/ALOX5	2.88617141015221
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	31/1837	101/9376	1.56656623746207	MAPK3/GNAQ/POMC/ADCY7/CAMK2G/CREB3L2/TCF7L2/EP300/EDNRB/MAP2K1/GNAI2/DVL1/CREB3/CREBBP/MAPK1/RAF1/PRKACA/TCF7L1/GNAS/TCF7/WNT2B/MITF/FZD8/EDN1/WNT6/ADCY9/WNT9A/WNT5B/FZD9/PRKCG/FZD10	2.82577620102461
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	29/1837	93/9376	1.5915617445461	MAPK3/EGFR/GNAQ/MAP3K2/ADCY7/ATF4/CAMK2G/ITPR2/EGR1/MAPK8/MAP2K3/MAP2K1/SOS1/GNA11/MAPK1/PTK2B/RAF1/MAPK9/SOS2/MAPK14/MAP2K4/PRKACA/PLD1/MAP3K3/GNAS/JUN/HBEGF/ADCY9/CACNA1C	2.82996278720182
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	63/1837	238/9376	1.35105190688142	RASGRF2/MAPK3/RASA1/GNG12/EGFR/RAB5A/PIK3R1/PDGFB/FLT1/IGF2/TIAM1/PAK2/AKT3/ETS2/SHOC2/FGFR1/MAPK8/VEGFB/MAP2K1/REL/RAP1B/SOS1/RASAL2/RAB5B/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/CSF1R/MAPK9/BAD/RGL2/RRAS2/GNB1/RASSF1/KSR1/NFKB1/SOS2/RALGDS/RALGAPB/MET/GAB1/ABL2/GNG10/PRKACA/GNB5/IKBKG/BCL2L1/PLD1/CHUK/RAC1/EXOC2/EFNA1/MRAS/FGF1/RHOA/PIK3CD/RASGRF1/PIK3R2/ANGPT2/PLA2G6/PRKCG	2.70780622799989
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	33/1837	110/9376	1.53119216113228	SERPINE1/MAPK3/IFNGR2/CDKN1A/EGFR/PIK3R1/EPAS1/FLT1/CAMK2G/HMOX1/AKT3/EP300/MAP2K1/IFNGR1/STAT3/EGLN3/CREBBP/PIK3CB/MAPK1/PIK3CA/RELA/RPS6KB2/LTBR/NFKB1/RPS6KB1/PFKFB3/MTOR/EGLN2/PIK3CD/PIK3R2/EDN1/ANGPT2/PRKCG	2.76621031735623
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/1837	19/9376	2.41767183336676	HEXB/GNS/IDS/NAGLU/HEXA/HGSNAT/GLB1/GUSB/GALNS	3.0532863855033
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	25/1837	78/9376	1.63588906103876	SERPING1/MAPK3/ITGB1/FOS/IRF1/MAPK8/GNAI2/MAPK1/RELA/MAPK9/IRF3/NFKB1/CASP7/C2/MAPK14/IRF8/ITGA5/JUN/ITGB2/TRAF6/C4BPB/RHOA/LY96/TICAM1/ITGAM	2.78366666792341
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	41/1837	144/9376	1.4532147825561	RB1CC1/GNAQ/PIK3R1/ATXN1/ITPR2/AKT3/ATXN2/MAPK8/RBPJ/XBP1/WIPI1/BECN1/PUM1/PIK3CB/PIK3CA/VLDLR/PUM2/MAPK9/ATG13/SP1/GTF2B/PSMA5/KAT5/ATXN2L/BEAN1/PSMD8/MTOR/SLC1A6/ULK2/PIK3C3/TBP/ATXN1L/ATG14/ULK1/ATG2B/MAP3K5/CIC/CACNA1A/PIK3CD/PIK3R2/PRKCG	2.7053331841412
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	19/1837	55/9376	1.76319097342505	HEXB/UGCG/PSAP/SGMS2/ASAH1/HEXA/B4GALT5/GLB1/ARSA/SGPP1/NEU1/KDSR/ACER3/SPTLC2/SMPD1/SPHK1/SPTLC3/ACER2/CERK	2.80199051356654
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	54/1837	201/9376	1.37121686071548	GADD45B/ASPSCR1/IL2RB/CDKN1A/PTK2/FLT1/HPGD/IL1R2/RXRA/IGFBP3/ARNT2/NFKBIZ/GADD45A/BMI1/NCOR1/CEBPA/REL/FUT8/AFF1/FOXO1/MAX/KMT2A/CEBPB/JMJD1C/RELA/CSF1R/RXRB/TGFBR2/MDM2/JUP/SP1/RUNX1/KLF3/NFKB1/ELK4/RARA/BCL6/MET/SUPT3H/DOT1L/DDIT3/BCL2L1/ETV6/PER2/MMP9/MLLT3/ELANE/NR4A3/TFE3/MITF/CD40/SIX4/ITGAM/TMPRSS2	2.62606838112414
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	29/1837	95/9376	1.55805518150302	ATP6V0D1/HLA-DRA/TGFB2/ATP6V0E1/FLT1/FOS/ATP6AP1/HLA-DPA1/ATP6V1G1/HLA-DPB1/ATP6V1B2/HLA-DRB1/ATP6V1D/ATP6V1E1/ATP6V1C1/ATP6V0B/ATP6V0A1/CCL5/HLA-DMA/CXCL2/HLA-DQB1/HLA-DQA1/HLA-DMB/JUN/ITGB2/ICAM1/ATP6V1E2/HLA-DQA2/IL11	2.69851543125239
NA	NA	hsa04519	Cadherin signaling	99/1837	404/9376	1.25072627023181	MAPK3/TJP1/PKP2/EGFR/PTK2/AMOTL2/TEAD1/KRT8/KRT7/KRT19/KRT10/EVL/VAV3/WWTR1/MYO1C/TCF7L2/YWHAG/NCSTN/NFKBIA/ADAM10/ANKRD6/SHOC2/EP300/FGFR1/GJA1/MAPK8/MAP2K3/TAOK1/DAAM1/MAP2K1/CSNK1A1/STK3/CTNND2/NCKAP1/DVL1/TAOK3/CREBBP/VASP/KRT18/TMC4/ARPC2/MAPK1/PTK2B/RYK/RAF1/RELA/MAPK9/AMOTL1/KRT15/RRAS2/KRT14/LATS1/JUP/BRK1/ARPC1B/APH1B/FMN1/NFKB1/ATN1/APC/FAT1/PCDH1/SAV1/PSEN1/MET/MAPK14/LIMA1/IKBKG/CIB2/TCF7L1/CELSR1/CHUK/NF2/RAC1/MYO1D/TMC1/TCF7/WNT2B/MRAS/RHOA/CDH8/CDH23/KRT13/FZD8/CDH16/CELSR2/WASF1/WNT6/LHFPL5/AJUBA/ACTR3C/CDH18/KRT17/WNT9A/WNT5B/FZD9/CELSR3/FZD10/SCN1B	2.54289972603492
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	38/1837	133/9376	1.45827824869741	MAOA/PPP2CB/CREB5/GNG12/GNAQ/FOS/PPP2R5E/ATF4/CAMK2G/ITPR2/CREB3L2/AKT3/MAPK8/GNAI2/CREB3/PPP2CA/MAPK9/GNB1/GSK3A/PPP2R5A/PPP2R2D/ATF6B/PPP3CB/ATF2/PPP2R3C/PPP3CC/MAPK14/CLOCK/GNG10/PRKACA/GNB5/GNAL/GNAS/PPP2R5B/CACNA1A/DDC/CACNA1C/PRKCG	2.62743471321139
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1837	41/9376	1.86730751357595	MAPK3/CDKN1A/EGFR/DAPK1/MAP2K1/RB1/DAPK3/MAPK1/RAF1/MDM2/RASSF1/ARAF/RPS6KA5/MMP9/HBEGF	2.74720596410862
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	56/1837	212/9376	1.34821951294666	MAPK3/EGFR/GNAQ/PIK3R1/PDGFB/FLT1/ITGB1/TIAM1/ADCY7/EVL/VAV3/AKT3/FGFR1/MAP2K3/VEGFB/MAP2K1/RAP1B/GNAI2/LPAR2/VASP/BCAR1/PARD3/CRK/PIK3CB/MAPK1/PIK3CA/RAF1/CSF1R/RAPGEF2/SIPA1/TLN2/PRKCI/PARD6B/RALGDS/CRKL/MET/MAPK14/ADORA2B/PARD6G/GNAS/RAC1/ITGB2/EFNA1/MRAS/ID1/FGF1/RAPGEF3/RHOA/PIK3CD/PIK3R2/RAP1GAP/SIPA1L3/ADCY9/ITGAM/ANGPT2/PRKCG	2.53140619524236
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	21/1837	65/9376	1.64897617352707	CREB5/GNAQ/SCARB1/POMC/ADCY7/ATF4/ITPR2/CREB3L2/LDLR/GNA11/CREB3/HSD3B1/SP1/ATF6B/ATF2/PRKACA/ORAI1/GNAS/AGTR1/ADCY9/CACNA1C	2.59161575901246
Human Diseases	Cancer: specific types	hsa05218	Melanoma	23/1837	73/9376	1.60810135644029	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/PDGFB/AKT3/GADD45A/FGFR1/MAP2K1/RB1/PIK3CB/MAPK1/PIK3CA/RAF1/BAD/MDM2/MET/ARAF/MITF/FGF1/PIK3CD/PIK3R2	2.57459686704692
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	15/1837	42/9376	1.82284781087176	MAP1LC3B/SAT1/FTL/ACSL3/SLC39A8/HMOX1/ACSL5/PCBP1/GPX4/ATG5/PCBP2/ACSL4/SLC11A2/SLC39A14/GCLC	2.63811431004083
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	49/1837	184/9376	1.35921043288916	RHOD/MAPK3/SSH2/BMPR2/RASA1/PIK3R1/PTK2/EPHB2/NTN4/ITGB1/SEMA5A/CAMK2G/PAK2/PDPK1/EFNB1/GNAI2/PLXNB2/PARD3/PIK3CB/MAPK1/PIK3CA/RYK/RAF1/PPP3R1/PARD6B/SSH3/EFNB2/LIMK1/SEMA3C/ARHGEF12/PPP3CB/CXCR4/BMPR1B/PPP3CC/DPYSL2/MET/NFATC3/SRGAP1/PARD6G/RAC1/EFNA1/RHOA/PIK3CD/PIK3R2/SEMA4A/PLXNC1/SEMA6D/L1CAM/WNT5B	2.42904852159826
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	19/1837	59/9376	1.64365260234539	CMPK1/UPP1/NME3/NT5E/UCK2/ENTPD4/DCTD/NME4/CANT1/ENTPD1/CDA/NME6/TK2/RRM2B/NT5C2/ENTPD5/ENTPD8/CMPK2/AK9	2.44806436542532
Human Diseases	Cancer: specific types	hsa05214	Glioma	23/1837	76/9376	1.54462367131765	MAPK3/GADD45B/CDKN1A/EGFR/PIK3R1/PDGFB/CAMK2G/AKT3/GADD45A/MAP2K1/RB1/SOS1/PIK3CB/MAPK1/PIK3CA/RAF1/MDM2/SOS2/MTOR/ARAF/PIK3CD/PIK3R2/PRKCG	2.3531259866937
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	38/1837	140/9376	1.38536433626254	SERPINE1/SPP1/PRKAG2/MAPK3/MAP1LC3B/GNG12/GNAQ/TGFBR1/ADCY7/ITPR2/AKT3/EGR1/SMAD4/SMAD3/SMAD2/MAP2K1/GNAI2/BECN1/GNA13/MAPK1/RAF1/RPS6KB2/RRAS2/HDAC5/GNB1/RPS6KB1/KLF2/MTOR/PIK3C3/GNG10/PRKACA/GNB5/SPHK1/PRKCE/AGTR1/MRAS/MYL2/ADCY9	2.26765467996644
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	40/1837	149/9376	1.37019432763515	MAPK3/RHEB/EGFR/PIK3R1/PDGFB/ADCY7/AKT3/CYTH2/MAP2K1/SOS1/DNM2/LPAR2/AGPAT1/GNA13/CYTH3/PIK3CB/MAPK1/PIK3CA/PTK2B/CYTH1/RAF1/ARF1/RRAS2/SOS2/RALGDS/MTOR/GAB1/SPHK1/TSC2/PLD1/DGKA/GNAS/AGTR1/MRAS/RAPGEF3/RHOA/PIK3CD/PIK3R2/ADCY9/PIP5K1B	2.24841243495706
NA	NA	hsa04518	Integrin signaling	41/1837	154/9376	1.35885018628622	FBN1/SPP1/EGFR/PIK3R1/PTK2/PDGFB/FLT1/ITGB1/FN1/AKT3/LAMA5/LAMC1/LIMS2/VEGFB/PARVA/FLNB/PIK3CB/PIK3CA/TLN2/ITGA3/COL4A2/MET/MTOR/LAMA3/ITGB4/LAMB2/ITGA2/COL4A1/ITGB6/LAMC2/ITGAD/RAC1/ITGA5/ITGB2/THBS3/LAMB3/ICAM1/PIK3CD/PIK3R2/PARVG/ITGAM	2.216380508504
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	32/1837	115/9376	1.42023620742704	MAPK3/CREB5/GNG12/GNAQ/PIK3R1/FOS/ADCY7/ATF4/CAMK2G/ITPR2/CREB3L2/AKT3/CHRM5/MAP2K1/GNAI2/GNA11/CREB3/KCNJ2/PIK3CB/MAPK1/PIK3CA/GNB1/GNG10/PRKACA/GNB5/JAK2/CACNA1A/PIK3CD/PIK3R2/ADCY9/CACNA1C/PRKCG	2.23818917600138
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	21/1837	69/9376	1.55338335187333	MAOA/CREB5/FOSB/FOS/ATF4/CAMK2G/CREB3L2/CREB3/PPP3R1/ATF6B/PPP3CB/ATF2/PPP3CC/PRKACA/SIRT1/GNAS/JUN/DDC/STX1A/CACNA1C/PRKCG	2.2773465461759
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	55/1837	217/9376	1.29363393029609	KLF4/MAPK3/CREB5/EGFR/PIK3R1/FOS/ADCY7/ATF4/RXRA/KLF5/CREB3L2/AKT3/XIAP/NOTCH2/MAP2K1/GNAI2/RB1/SOS1/STAT3/CREB3/KPNA4/KPNA3/GSTT1/PIK3CB/MAPK1/PIK3CA/KPNA6/RAF1/RELA/BAD/RXRB/RPS6KB2/PPARA/NFKB1/SOS2/RPS6KA3/BCL6/ATF6B/ATF2/RPS6KB1/MTOR/GSTA3/PRKACA/GNAS/JUN/JAK2/CACNA1A/PIK3CD/PIK3R2/MIR29A/ADCY9/ESR2/CACNA1C/PRKCG/HSP90AA1	2.16020725498347
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	44/1837	168/9376	1.33675506130596	TNFSF10/SQSTM1/IFNGR2/CAPN2/FTL/STAT1/CAMK2G/TNFRSF1A/IFNAR1/XIAP/TRADD/STAT4/MAPK8/CFLAR/EIF2AK2/CHMP1A/CHMP3/VPS4B/CHMP4C/IFNGR1/RBCK1/STAT3/CHMP2B/VPS4A/GLUL/MAPK9/CHMP1B/JAK1/CHMP5/STAT6/TNFAIP3/FADD/RIPK1/SMPD1/CYLD/PYGB/PPIA/JAK2/SPATA2L/USP21/TNFRSF10A/TICAM1/MLKL/HSP90AA1	2.17404966946701
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	22/1837	75/9376	1.49716566866267	MAPK3/CDKN1A/PIK3R1/AKT3/PDPK1/XIAP/GSTT1/PIK3CB/MAPK1/PIK3CA/BAD/MDM2/ERCC1/FADD/GSTA3/BCL2L1/MAP3K5/BBC3/ATP7A/PIK3CD/PIK3R2/POLH	2.13378317017145
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	8/1837	20/9376	2.04158954817637	UGDH/CYB5R1/NANS/CYB5R3/GNE/CYB5R2/GMDS/NANP	2.30170599715025
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	20/1837	67/9376	1.52357428968386	MAPK3/GNAQ/ATF4/CAMK2G/ITPR2/EP300/MAP2K1/RAP1B/CREBBP/MAPK1/RAF1/PPP3R1/RPS6KA3/PPP3CB/PPP3CC/PRKACA/ARAF/RAPGEF3/CACNA1C/PRKCG	2.12298801827434
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	18/1837	59/9376	1.557144570643	MGLL/PIK3R1/PTGER3/ADCY7/AKT3/IRS2/GNAI2/PIK3CB/PIK3CA/PNPLA2/PRKACA/GNAS/PRKG1/PIK3CD/NPY1R/FABP4/PIK3R2/ADCY9	2.11904024750517
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/1837	39/9376	1.70132462348031	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-E/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DQA2/CD40/HLA-F	2.16636213414237
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	10/1837	28/9376	1.82284781087176	ATP6V0D1/ATP6V0E1/ATP6V1G1/CA2/ATP6V1B2/ATP6V1D/ATP6V1E1/ATP6V1C1/ATP6V0A1/ATP6V1E2	2.15239773606348
Organismal Systems	Nervous system	hsa04730	Long-term depression	18/1837	60/9376	1.53119216113228	MAPK3/PPP2CB/GNAQ/ITPR2/MAP2K1/GNAI2/GNA11/LYN/GNA13/MAPK1/PPP2CA/RAF1/ARAF/GNAS/CACNA1A/PRKG1/CRH/PRKCG	2.03749188376467
Human Diseases	Immune disease	hsa05310	Asthma	11/1837	32/9376	1.75449101796407	PRG2/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DQA2/CD40	2.1103087173412
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	17/1837	56/9376	1.549420639241	HSPA1B/NFKBIA/RAB1A/SAR1B/CLK4/RAB1B/RELA/EEF1A1/ARF1/NFKB1/HSPA1A/NFKB2/CASP7/CXCL2/HSPA6/ITGB2/ITGAM	2.03551530363059
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	16/1837	52/9376	1.57045349859721	ABCA1/MYLIP/ANGPTL4/SCARB1/APOE/TSPO/SOAT1/LRP1/LDLR/VAPA/NPC1/NPC2/LCAT/CD36/LPL/CYP27A1	2.03612357375128
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	31/1837	116/9376	1.36399301710059	MAPK3/SLC38A1/GNG12/GNAQ/HOMER3/ADCY7/ITPR2/SLC1A3/SLC17A8/GNAI2/MAPK1/HOMER1/GLUL/GLS/SLC38A2/GNB1/PPP3R1/PPP3CB/PPP3CC/SLC1A6/GNG10/PRKACA/GNB5/PLD1/GNAS/SHANK2/CACNA1A/NCDN/ADCY9/CACNA1C/PRKCG	1.947152193096
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	21/1837	73/9376	1.46826645588027	BST2/SUPT5H/SERINC3/EP300/PDCD6IP/SMARCB1/VPS4B/TSG101/ELL2/CREBBP/VPS4A/HGS/AFF4/ELL/CXCR4/MX2/SAMHD1/PPIA/MLLT3/KAT2B/APOBEC3B	1.98255987671173
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/1837	21/9376	1.94437099826321	DSE/CHPF/CHPF2/CSGALNACT2/B4GALT7/CHST14/B3GALT6/CHST7	2.13852207442744
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1837	14/9376	2.18741737304612	B3GNT7/FUT8/B4GALT2/B4GALT3/ST3GAL2/ST3GAL3	2.19465593039468
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	23/1837	82/9376	1.4316024270749	TAPBP/LGMN/HLA-B/HLA-DRA/HSPA1B/CTSB/TAPBPL/HLA-DPA1/CD74/HLA-DPB1/HLA-DRB1/HLA-E/CTSS/HSPA1A/B2M/HLA-DMA/HLA-DQB1/HLA-DQA1/HSPA6/HLA-DMB/HLA-DQA2/HLA-F/HSP90AA1	1.93763876737678
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	31/1837	117/9376	1.35233495712538	MBD2/MORF4L2/RSF1/SMARCA1/PBRM1/BRD7/MBD3/CHD4/SMARCB1/EPC1/SRCAP/SMARCE1/BCL7C/ZNHIT1/CHD3/BAZ2A/BCL7B/BAZ2B/SMARCD1/CDK2AP1/EPC2/SMARCD2/MORF4L1/PHF6/YY1/KAT5/SMARCC2/PHF10/GATAD2B/INO80E/DPF1	1.89299718276255
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	15/1837	49/9376	1.56244098074723	MAOA/CREB5/FOSB/ATF4/CREB3L2/GNAI2/CREB3/RELA/NFKB1/ATF6B/ATF2/PRKACA/GNAS/JUN/DDC	1.94844141979678
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	20/1837	70/9376	1.45827824869741	HLA-B/HLA-DRA/HLA-DPA1/DAG1/HLA-DPB1/HLA-DRB1/HLA-E/EIF4G2/ABL2/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/RAC1/ITGB2/SNTB1/ICAM1/HLA-DQA2/CD40/HLA-F	1.89967840308318
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	12/1837	37/9376	1.65534287689976	MAPK3/GADD45B/CDKN1A/RXRA/TCF7L2/TFG/GADD45A/MAP2K1/MAPK1/RXRB/TCF7L1/TCF7	1.97152642463089
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	12/1837	38/9376	1.61178122224451	HEXB/UGDH/GFPT1/PGM3/HEXA/GALE/GNE/PMM2/GNPDA1/UXS1/PGM1/RENBP	1.86528136309129
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	12/1837	38/9376	1.61178122224451	MAPK3/PIK3R1/PDPK1/SGK1/PIK3CB/MAPK1/PIK3CA/ATP1A4/PIK3CD/PIK3R2/NEDD4L/PRKCG	1.86528136309129
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	24/1837	89/9376	1.37635250438857	TUBB2A/MAPK3/TJP1/EGFR/GNAQ/MAP3K2/PDGFB/ADCY7/ITPR2/GJA1/MAP2K1/GNAI2/SOS1/GNA11/MAPK1/RAF1/SOS2/PRKACA/GNAS/MAP2K5/PRKG1/TUBA4A/ADCY9/PRKCG	1.76090300903619
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	21/1837	76/9376	1.41030856946394	ANGPTL4/ACOX1/RXRA/ACSL3/UBC/PDPK1/SLC27A1/ACSL5/CPT1A/RXRB/ACSL4/PPARA/FABP7/OLR1/CD36/ACOX3/LPL/CYP27A1/FABP4/PLIN5/CPT1B	1.77279800386346
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	28/1837	107/9376	1.33561933058267	PRKAG2/CREB5/GNAQ/SIK1/ATF4/CAMK2G/ITPR2/CREB3L2/AKT3/EP300/PHKB/CPT1A/FOXO1/CREB3/CREBBP/PPP3R1/PPARA/PPP3CB/ATF2/PPP3CC/PRKACA/PYGB/SIRT1/SIK2/GNAS/FBP1/ACACB/CPT1B	1.72347806043091
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	54/1837	226/9376	1.21953357966288	MAPK3/CREB5/PIK3R1/ACOX1/POMC/PTGER3/FOS/TIAM1/ADCY7/CAMK2G/VAV3/CREB3L2/AKT3/NFKBIA/EP300/MAPK8/PDE10A/MAP2K1/RAP1B/HCAR2/GLI3/GNAI2/CREB3/CREBBP/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/BAD/RRAS2/PPARA/NFKB1/ATP1A4/PRKACA/PDE4C/PLD1/ORAI1/GNAS/RAC1/JUN/ACOX3/PDE4A/HCAR1/RAPGEF3/RHOA/PIK3CD/NPY1R/PIK3R2/EDN1/ADCY9/CRH/CACNA1C	1.64902779610177
Organismal Systems	Immune system	hsa04611	Platelet activation	32/1837	126/9376	1.29624733217548	SNAP23/MAPK3/GNAQ/PIK3R1/VAMP8/ITGB1/ADCY7/ITPR2/AKT3/RAP1B/GNAI2/VASP/LYN/GNA13/PIK3CB/MAPK1/PIK3CA/TLN2/PRKCI/ARHGEF12/ARHGEF1/MAPK14/PRKACA/ITGA2/ORAI1/GNAS/PRKG1/RHOA/PIK3CD/PIK3R2/ADCY9/TBXAS1	1.6525408313199
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	88/1837	388/9376	1.15760232113093	TUBB2A/MAPK3/RB1CC1/GNAQ/PIK3R1/CAPN2/RTN4/APOE/ATF4/SLC39A8/SLC39A13/ITPR2/TNFRSF1A/CSNK2A2/AKT3/NCSTN/SLC39A6/ADAM10/IRS2/SLC39A7/CHRM5/MAPK8/BACE2/EIF2AK2/LRP1/RTN3/XBP1/MAP2K1/WIPI1/SLC39A1/CSNK1A1/DVL1/SLC39A11/SLC39A4/BECN1/PIK3CB/MAPK1/PIK3CA/SLC39A9/RAF1/RELA/MAPK9/BAD/ATG13/ATF6/PPP3R1/APH1B/PSMA5/NFKB1/APC/SLC11A2/SLC39A14/KLC1/CASP7/PPP3CB/COX7A2L/FADD/PSEN1/PPP3CC/FRAT1/PSMD8/MTOR/NDUFA13/ULK2/PIK3C3/IKBKG/DDIT3/ARAF/ATG14/ULK1/ATG2B/CHUK/KLC4/MAP3K5/LPL/WNT2B/MAPT/PIK3CD/TUBA4A/FZD8/PIK3R2/WNT6/WNT9A/CACNA1C/WNT5B/FZD9/NOX4/FZD10	1.56505745284507
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	18/1837	65/9376	1.41340814873749	SPP1/MAPK3/GNAQ/PIK3R1/ITPR2/AKT3/MAP2K1/GNA11/PIK3CB/MAPK1/PIK3CA/RAF1/KISS1R/PIK3CD/PIK3R2/ESR2/CACNA1C/PRKCG	1.65090047505042
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	6/1837	16/9376	1.91399020141535	HEXB/HEXA/NAGA/A4GALT/ST8SIA1/ST3GAL2	1.80612145428366
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	39/1837	160/9376	1.24409363091998	ESAM/PVR/CLDN19/JAM2/HLA-B/HLA-DRA/PDCD1LG2/MAG/PTPRF/ITGB1/GLG1/CD274/HLA-DPA1/CLDN4/HLA-DPB1/SDC4/HLA-DRB1/CD22/F11R/HLA-E/CD99L2/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/ITGB2/CLDN9/CLDN23/ICAM1/CLDN14/CLDN8/HLA-DQA2/CD40/NLGN4X/HLA-F/CLDN15/SELPLG/ITGAM/L1CAM	1.53719353969142
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	28/1837	110/9376	1.29919334883951	MAPK3/ANAPC13/ANAPC16/PIK3R1/ADCY7/AKT3/MAPK8/MAP2K1/MAD2L2/GNAI2/PIK3CB/MAPK1/PIK3CA/RAF1/CDC26/MAPK9/CPEB2/CPEB4/STK10/RPS6KA3/CDC16/MAPK14/PRKACA/ARAF/PIK3CD/PIK3R2/ADCY9/HSP90AA1	1.55806464967414
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	25/1837	98/9376	1.30203415062269	CREB5/GNAQ/SCARB1/POMC/ADCY7/ATF4/CAMK2G/ITPR2/CREB3L2/DAGLB/LDLR/GNA11/CREB3/HSD3B1/ATP1A4/ATF6B/ATF2/PRKACA/ORAI1/GNAS/PRKCE/AGTR1/ADCY9/CACNA1C/PRKCG	1.48362877989187
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/1837	37/9376	1.51739763715812	UGDH/GFPT1/PGM3/GALE/NANS/GNE/PMM2/UXS1/PGM1/GMDS/NANP	1.55653345699648
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	14/1837	50/9376	1.42911268372346	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/LTBR/CXCR4/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DQA2/CD40/AICDA/CCL28	1.50173047088954
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	9/1837	29/9376	1.5839918908265	TEAD1/WWTR1/STK3/LATS1/RASSF1/SAV1/RASSF2/NF2/AJUBA	1.55472305563817
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	25/1837	100/9376	1.27599346761023	CD9/IL1R1/HLA-DRA/CD59/IL1R2/CSF2RA/HLA-DPA1/HLA-DPB1/HLA-DRB1/CSF1R/CD22/IL4R/ITGA3/EPOR/HLA-DMA/ITGA2/HLA-DQB1/HLA-DQA1/CD36/HLA-DMB/ITGA5/CD37/HLA-DQA2/IL11/ITGAM	1.36962532509421
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	67/1837	298/9376	1.14753774939444	INHA/TNFSF10/IL6ST/CSF2RB/TNFRSF12A/IL2RB/BMPR2/IFNGR2/IL1RAP/IL1R1/GDF15/TGFB2/EBI3/TGFBR1/CSH1/IL1R2/CSF2RA/IL13RA1/TNFRSF1A/XCR1/IFNAR1/IFNGR1/IL10RB/CXCR6/CSH2/IL17D/IL17RE/CSF1R/IL4R/TGFBR2/OSMR/LTBR/ACVRL1/ACVR2B/CXCR4/IL27RA/BMPR1B/EPOR/RELL2/RELL1/CCL5/CXCL2/TNFRSF25/CXCL16/ACKR3/CLCF1/IL27/RELT/ACVR1B/IL17B/IL18R1/IL17RC/TNFRSF14/CD40/TNFRSF10A/IL11/CSHL1/CXCL9/CXCL10/IL34/EDA2R/CTF1/CCL28/TNFRSF10C/IL2RG/TNFRSF10D/INHBA	1.27761364598876
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	12/1837	44/9376	1.39199287375662	TAF7/GTF2I/TAF13/TAF5L/GTF2E2/GTF2A1/TAF11/GTF2B/GTF2H1/TBP/TAF1/TAF4B	1.28647244863753
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	12/1837	44/9376	1.39199287375662	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-E/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-F	1.28647244863753
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/1837	89/9376	1.26165646235619	SPP1/HSPG2/ITGB1/FN1/DAG1/LAMA5/LAMC1/SDC4/ITGA3/COL4A2/LAMA3/ITGB4/AGRN/LAMB2/ITGA2/COL4A1/ITGB6/LAMC2/CD36/ITGA5/THBS3/LAMB3	1.22425557562138
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1837	71/9376	1.29396520659066	MAPK3/SLC1A5/EGFR/PIK3R1/AKT3/FGFR1/MAP2K1/PIK3CB/MAPK1/PIK3CA/RAF1/GLS/MET/MTOR/SIRT6/PIK3CD/SIRT3/PIK3R2	1.22729866310981
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	7/1837	23/9376	1.55338335187333	B4GALT2/B4GALT3/POMGNT1/POMT2/FKRP/B3GAT2/ST3GAL3	1.31158936066755
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/1837	49/9376	1.3541155166476	GALNT7/PLOD3/GALNT6/GALNT3/B4GALT2/POFUT2/B4GALT3/FUT11/XXYLT1/POMT2/GALNT12/LFNG/ST3GAL3	1.22674798538373
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	24/1837	99/9376	1.23732699889477	HLA-DRA/KRT19/KRT10/HLA-DPA1/HLA-DPB1/HLA-DRB1/KRT18/KRT15/KRT14/C2/HLA-DMA/HLA-DQB1/HLA-DQA1/FCGR3A/HLA-DMB/ITGB2/ICAM1/HLA-DQA2/FPR3/KRT13/CFB/SELPLG/ITGAM/KRT17	1.17177522417803
NA	NA	hsa04382	Cornified envelope formation	49/1837	217/9376	1.15251022880924	COL17A1/TJP1/PPP2CB/CLDN19/PKP2/UGCG/KRT8/KRT7/KRT19/KRT10/PPP2R5E/S100A13/SLC27A1/LAMA5/CLDN4/PCSK6/KRT18/PRSS8/KDSR/PPP2CA/KRT15/DST/KRT14/JUP/SPTLC2/PPP2R5A/COL4A2/PPP2R2D/KAZN/PPP2R3C/SPRR2G/LAMA3/S100A10/ITGB4/COL4A1/LAMC2/S100A2/CLDN9/LAMB3/CLDN23/PPP2R5B/SPTLC3/CLDN14/CLDN8/KRT13/S100A4/CLDN15/PPL/KRT17	1.12198785201938
NA	NA	hsa04517	IgSF CAM signaling	66/1837	299/9376	1.12662968377626	TUBB2A/MAPK3/TJP1/ESAM/PVR/RASA1/IL1RAP/JAM2/PIK3R1/PTK2/TJP2/MAG/PTPRF/ITGB1/VAV3/PAK2/AKT3/PDPK1/TRIO/FGFR1/CABLES1/MAPK8/WASL/MAP2K1/RAP1B/FOXO1/GIT1/BCAR1/LYN/ARPC2/PARD3/PIK3CB/MAPK1/PPFIA1/PIK3CA/MAPK9/RAPGEF2/F11R/PRKCI/ARPC1B/PARD6B/IQGAP1/MAPK14/BAIAP2/SRGAP1/PARD6G/RAC1/ITGA5/ITGB2/TRAF6/MBP/ICAM1/RHOA/CD84/PIK3CD/DOK1/TUBA4A/NLGN4X/PIK3R2/ACTR3C/ITGAM/CRTAM/EZR/CABLES2/L1CAM/PRKCG	1.09845758857046
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	12/1837	45/9376	1.36105969878425	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-E/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-F	1.1984075112117
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	16/1837	63/9376	1.29624733217548	GADD45B/CDKN1A/TCF7L2/GADD45A/GLI3/DVL1/APC/TCF7L1/TCF7/WNT2B/FZD8/WNT6/WNT9A/WNT5B/FZD9/FZD10	1.1645637460386
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	103/1837	480/9376	1.09522772636545	TUBB2A/MAPK3/PINK1/SQSTM1/MAP1LC3B/RB1CC1/RAB5A/GNAQ/HIP1/CAPN2/ATXN1/ATF4/CAMK2G/UBC/ITPR2/TNFRSF1A/CSNK2A2/ATXN2/OPTN/RAB1A/CHRM5/MAPK8/MAP2K3/UBE2J1/XBP1/MAP2K1/WIPI1/CSNK1A1/DNAH11/UBE2G2/DCTN6/DVL1/BECN1/MAPK1/CHMP2B/DCTN2/RAF1/RELA/MAPK9/BAD/DCTN1/ATG13/UBE2L6/SOD1/ATF6/ACTR10/UBE2G1/PPP3R1/GPX8/PSMA5/ATXN2L/NFKB1/APC/MFN1/KLC1/CASP7/PPP3CB/GPX3/COX7A2L/FADD/DAXX/DCTN4/PSEN1/PPP3CC/FRAT1/PSMD8/MAPK14/MTOR/NDUFA13/ULK2/PIK3C3/MFN2/SPG11/DDIT3/BCL2L1/ARAF/GPR37/ATXN1L/ATG14/ULK1/ATG2B/MAP3K10/DNALI1/DNAL4/KLC4/MAP3K5/RAC1/DNAL1/UBB/WNT2B/ZFYVE1/MAPT/TUBA4A/FZD8/WNT6/STX1A/WNT9A/CACNA1C/WNT5B/FZD9/NOX4/PRKCG/FZD10	1.05723124984068
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	30/1837	128/9376	1.19624387588459	ADCY7/NME3/NT5E/ENTPD4/PDE10A/DGUOK/NME4/CANT1/ENTPD1/PGM1/NUDT5/NME6/GDA/GMPR2/RRM2B/NUDT9/AMPD2/NT5C2/PDE4C/HPRT1/AK5/AMPD3/LACC1/ENTPD5/GUK1/PDE4A/ENTPD8/AK9/ADCY9/PDE6G	1.10347000310645
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	31/1837	133/9376	1.18964804498999	TNFSF10/MAPK3/IFNGR2/PIK3R1/HLA-B/VAV3/IFNAR1/MAP2K1/IFNGR1/SOS1/PIK3CB/MAPK1/PIK3CA/PTK2B/RAF1/TYROBP/HLA-E/PPP3R1/SOS2/PPP3CB/PPP3CC/ARAF/HCST/FCGR3A/RAC1/ITGB2/ICAM1/PIK3CD/TNFRSF10A/PIK3R2/PRKCG	1.08730418280967
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1837	24/9376	1.48865904554527	EXTL3/EXT2/NDST1/B4GALT7/B3GALT6/EXT1/GLCE	1.18315776646875
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	20/1837	83/9376	1.229873221793	PIPOX/ACOX1/ACSL3/ACSL5/ABCD1/PHYH/PRDX5/SOD1/ACSL4/SLC25A17/PRDX1/MLYCD/DECR2/PEX3/AGXT/PEX11B/PEX6/PEX7/ACOX3/PEX12	1.0383237909307
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/1837	83/9376	1.229873221793	ADAR/NFKBIA/POLR3D/PCBP1/RELA/IRF3/NFKB1/CASP7/FADD/ZCCHC3/NFKBIB/RIPK1/CCL5/IKBKG/POLR3A/SAMHD1/CHUK/TREX1/CXCL10/MLKL	1.0383237909307
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	5/1837	16/9376	1.59499183451279	MAOA/ALDH3B1/ALDH3B2/DDC/IL4I1	1.17575387107328
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	14/1837	56/9376	1.27599346761023	GLI3/CSNK1A1/SPOP/FBXW11/CSNK1G3/IQCE/SMURF1/PRKACA/SPOPL/BTRC/SMURF2/MEGF8/SCUBE2/EVC	1.02251150921231
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	10/1837	38/9376	1.34315101853709	QPRT/NT5E/NMRK1/NMNAT2/NT5C2/SIRT6/SIRT1/SIRT5/SIRT3/NMNAT3	1.04624525292673
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1837	75/9376	1.22495372890582	SERPINE1/GADD45B/CDKN1A/IGFBP3/GADD45A/PPP1R13L/SHISA5/MDM2/SESN2/RRM2B/BCL2L1/TSC2/GORAB/ZMAT3/BBC3/SESN3/TNFRSF10A/TP73	0.965477930319925
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/1837	34/9376	1.35105190688142	PRKAG2/FBXW11/CRY1/FBXL3/CLOCK/BTRC/SKP1/PER2/NR1D2	1.01221835469615
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	23/1837	99/9376	1.18577170727416	IL1RAP/GNAQ/PIK3R1/IL1R1/ADCY7/CAMK2G/ITPR2/MAPK8/MAP2K3/PIK3CB/PIK3CA/MAPK9/MAPK14/PRKACA/GNAS/PRKCE/PIK3CD/PTGER4/PIK3R2/ADCY9/PLA2G6/PRKCG/P2RY2	0.917226800789018
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/1837	54/9376	1.22873445029134	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-E/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DQA2/CD40/HLA-F	0.83206500161739
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/1837	31/9376	1.31715454721056	SEC63/SEC62/BAG6/TMEM208/SRP19/SPCS2/IMMP2L/SEC61G	0.87306279460322
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	20/1837	89/9376	1.14696042032381	GABARAPL2/SLC38A1/GNG12/GABARAP/ADCY7/GABARAPL1/GNAI2/GLUL/GLS/SLC38A2/GNB1/GNG10/PRKACA/TRAK2/GNB5/CACNA1A/ABAT/ADCY9/CACNA1C/PRKCG	0.687608142206573
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/1837	75/9376	1.15690074396661	CREB5/GNAQ/ADCY7/ATF4/ITPR2/CREB3L2/CREB3/GPX8/ATP1A4/ATF6B/ATF2/GPX3/GSR/PRKACA/GNAS/ADCY9/PRKCG	0.673401620357042
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/1837	28/9376	1.27599346761023	ST3GAL6/B3GNT3/B4GALT2/B4GALT3/A4GALT/ST8SIA1/ST3GAL3	0.721941174301984
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	22/1837	100/9376	1.12287425149701	TNFSF10/IL6ST/IL2RB/TNFRSF1A/XCR1/IL10RB/CSF1R/LTBR/CXCR4/CCL5/CXCL2/ACKR3/IL18R1/TNFRSF14/TNFRSF10A/CXCL9/CXCL10/IL34/CCL28/TNFRSF10C/IL2RG/TNFRSF10D	0.609766919882181
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	33/1837	154/9376	1.09370868652306	MAPK3/PPP2CB/CREB5/GNAQ/TPM1/PPP2R5E/ADCY7/ATF4/CAMK2G/CREB3L2/AKT3/GNAI2/CREB3/MAPK1/PPP2CA/PPP2R5A/ATP1A4/PPP2R2D/ATF6B/ATF2/PPP2R3C/MAPK14/PRKACA/RPS6KA5/GNAS/PPP2R5B/AGTR1/CACNA2D3/RAPGEF3/MYL2/ADCY9/CACNA1C/SCN1B	0.578776643358232
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	19/1837	86/9376	1.12762213416718	CREB5/GNAQ/VAMP2/ADCY7/ATF4/CAMK2G/CREB3L2/GNA11/CREB3/ATP1A4/ATF6B/ATF2/PRKACA/GNAS/STX1A/ADCY9/CACNA1C/RAB3A/PRKCG	0.586881900697984
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	35/1837	166/9376	1.07613906906887	MAPK3/CREB5/GNAQ/ADCY7/ATF4/ITPR2/CREB3L2/AKT3/IRS2/GTF2I/EDNRB/MAP2K1/GNAI2/GNA11/CREB3/VASP/GNA13/MAPK1/RAF1/BAD/PPP3R1/ATP1A4/ATF6B/PPP3CB/ATF2/PPP3CC/RGS2/NFATC3/PRKCE/AGTR1/PRKG1/RHOA/ADCY9/CACNA1C/NPPB	0.488556882932743
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	33/1837	157/9376	1.07280979442389	PRKAG2/PIK3R1/MLXIP/FOS/ATF4/RXRA/TNFRSF1A/AKT3/IRS2/MAPK8/XBP1/CEBPA/ADIPOR1/PIK3CB/PIK3CA/RELA/MAPK9/ITCH/PPARA/GSK3A/NFKB1/CASP7/COX7A2L/MAPK14/NDUFA13/BCL2L11/DDIT3/SOCS3/MAP3K5/RAC1/JUN/PIK3CD/PIK3R2	0.454130915742043
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	29/1837	138/9376	1.07257421915063	MAPK3/ANAPC13/PPP2CB/ANAPC16/PPP2R5E/ADCY7/CAMK2G/ITPR2/YWHAG/MAP2K1/MAD2L2/FBXW11/MAPK1/PPP2CA/CDC26/CPEB2/PPP3R1/CPEB4/PPP2R5A/RPS6KA3/CDC16/PPP3CB/PPP3CC/MAPK14/PRKACA/BTRC/SKP1/PPP2R5B/ADCY9	0.423951602068208
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1837	30/9376	1.19092723643622	FOLR1/RELA/NFKB1/IKBKG/CHUK/MTHFR/ABCC3	0.517010031970029
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1837	69/9376	1.10955953705238	GNAQ/CTSB/ITPR2/GNAI2/KCNJ2/PPP3R1/PPP3CB/PPP3CC/PRKACA/ORAI1/GNAS/AGTR1/PTGER4/EDN1/CACNA1C	0.450871954246963
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	48/1837	233/9376	1.05146242824534	FBN1/BGN/FMNL2/FHL2/PKP2/SYNE1/HSPG2/FBLN1/ITGB1/FN1/TPM1/TMOD3/DAG1/PDLIM5/DAAM1/SUN1/MYOZ1/SDC4/FBN2/TMEM43/DIAPH1/TLN2/JUP/ITGA3/COL11A1/SYNE2/ATP1A4/COL4A2/FHL1/DIAPH2/LMNA/AMPD2/NEBL/ITGB4/AGRN/ITGA2/COL4A1/ITGB6/AMPD3/SYNE3/ITGA5/THBS3/ANKRD1/SNTB1/FMNL1/MYL2/TNNT3/PDLIM3	0.392651462854162
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	22/1837	104/9376	1.07968678028558	LYPLA1/LPIN2/SGMS2/PLD3/LPCAT1/CDIPT/AGPAT1/GPAM/LPCAT2/CRLS1/MBOAT7/GDPD5/PCYT2/PNPLA6/GPCPD1/PLD1/LCAT/CHKB/DGKA/LPCAT4/LPIN1/PLA2G6	0.403366273161554
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	28/1837	134/9376	1.0665020027787	MAPK3/GNAQ/ADM/ADCY7/ITPR2/MAP2K1/GNA11/GNA13/MAPK1/RAF1/ARHGEF12/ARHGEF1/PPP1R12B/ADORA2B/PRKACA/ARAF/GNAS/PRKCE/AGTR1/PRKG1/RHOA/EDN1/ADCY9/ARHGEF11/PLA2G6/CACNA1C/NPPB/PRKCG	0.38272557705195
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	32/1837	154/9376	1.06056599905266	PRKAG2/MAPK3/CDKN1A/EGFR/GNAQ/FOS/ADCY7/CAMK2G/ITPR2/MAP2K1/GNAI2/KCNJ2/MAPK1/RAF1/PPP3R1/PPP3CB/CAMKK2/PPP3CC/PPP1R12B/RGS2/NFATC3/PRKACA/RCAN1/EEF2/GNAS/JUN/MAP2K5/CACNA2D3/RHOA/ADCY9/CACNA1C/PRKCG	0.374076160215011
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	48/1837	235/9376	1.04251381183474	PRKAG2/MGLL/CREB5/RHEB/ADCY7/ACSL3/CREB3L2/ACSL5/FGFR1/MAP2K3/SMARCB1/CPT1A/SMARCE1/SOS1/COX14/CREB3/FRS2/COX19/RPS6KB2/ACSL4/SMARCD1/SMARCD2/SMARCC2/SOS2/RPS6KA3/AKT1S1/ATF2/COX7A2L/RPS6KB1/MAPK14/PNPLA2/MTOR/NDUFA13/PRKACA/KDM3A/SIRT6/TSC2/MAP3K5/GNAS/SLC25A20/DPF1/RPTOR/PRKG1/COX18/KLB/ADCY9/NPPB/CPT1B	0.325799540452767
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	24/1837	115/9376	1.06517715557028	MAPK3/MAOA/GNG12/GNAQ/DUSP1/ITPR2/MAP2K1/GNAI2/MAPK1/RAF1/GNB1/SLC6A4/GNG10/PRKACA/GNB5/ARAF/GNAS/CACNA1A/RAPGEF3/HTR3E/DDC/ALOX5/CACNA1C/PRKCG	0.347135257604593
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	8/1837	36/9376	1.13421641565354	GALNT7/GALNT6/GALNT3/B4GALT5/B3GNT3/ST6GALNAC2/ST3GAL2/GALNT12	0.398260095411353
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/1837	76/9376	1.07452081482967	GNAQ/ADCY7/CAMK2G/ITPR2/SLC4A2/GNAI2/CA2/KCNJ2/ATP1A4/KCNJ15/PRKACA/GNAS/KCNJ16/ADCY9/EZR/PRKCG	0.321978046787854
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1837	17/9376	1.20093502833904	LAMP2/LAMP1/DAG1/PCDH1	0.409306587361148
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/1837	97/9376	1.05236574648267	MAPK3/GNG12/GNAQ/FOS/ADCY7/CAMK2G/GNAI2/MAPK1/GNB1/GNG10/PRKACA/GNB5/PER2/RPS6KA5/GNAS/PRKG1/RASD1/ADCY9/CACNA1C/PRKCG	0.255897429453403
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1837	27/9376	1.13421641565354	ACOX1/ACOT7/FADS1/TECR/ACOX3/ACOT2	0.34473730594143
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1837	37/9376	1.10356191793318	GFPT1/GLUL/GLS/RIMKLA/AGXT/ABAT/GPT/IL4I1	0.311554554093277
NA	NA	hsa04081	Hormone signaling	44/1837	219/9376	1.02545593744019	GNG12/GNAQ/PIK3R1/POMC/CSH1/IGF2/ADCY7/IRS2/SMAD4/GNAI2/ADIPOR1/GUCA2A/STAT3/THRB/GNA11/GNA13/CSH2/PIK3CB/PIK3CA/APPL1/GNB1/STK11/BMPR1B/EPOR/GNG10/PRKACA/GNB5/GNAS/HAMP/JAK2/AGTR1/GUCA2B/PRKG1/RAPGEF3/RHOA/PIK3CD/CSHL1/PIK3R2/ADCY9/CRH/ESR2/NPPB/GNA15/UCN	0.188155921222949
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1837	63/9376	1.05320095739257	DDB1/POLD4/RAD23B/POLR2C/CUL4B/RFC1/XPC/ERCC1/GTF2H1/ERCC4/ERCC5/UVSSA/ERCC6	0.209135744038491
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/1837	53/9376	1.05931533160095	GNAQ/CLTB/CLTC/AP2B1/AP2A2/DNM2/ATP1A4/PRKACA/GNAS/ADCY9/PRKCG	0.213752104878593
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1837	18/9376	1.13421641565354	ACSL3/ACSL5/ACSL4/ACACB	0.281341444738023
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1837	18/9376	1.13421641565354	LMBRD1/CD320/PRDX1/ZNF76	0.281341444738023
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	17/1837	86/9376	1.00892506741274	PKP2/ITGB1/TCF7L2/DAG1/GJA1/JUP/ITGA3/LMNA/ITGB4/ITGA2/ITGB6/TCF7L1/ITGA5/TCF7/SNTB1/CACNA2D3/CACNA1C	0.0410427279031921
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1837	50/9376	1.02079477408819	AOC1/MAOA/PYCR1/SAT1/OAT/P4HA2/AMD1/ALDH18A1/P4HA1/L3HYPDH	0.0727737656517741
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	31/1837	158/9376	1.00141259483335	ANAPC13/GADD45B/PPP2CB/CDKN1A/ANAPC16/TGFB2/CDKN1C/PPP2R5E/YWHAG/GADD45A/EP300/SMAD4/PDS5A/RBL2/SMAD3/SMAD2/MAD2L2/NIPBL/RB1/CREBBP/PPP2CA/CDC26/MDM2/PPP2R5A/CDC16/MAU2/SKP1/CDC14A/CDKN2D/CDKN2B/PPP2R5B	0.0088391631442888
Cellular Processes	Cell motility	hsa04814	Motor proteins	38/1837	194/9376	0.999747459158534	TUBB2A/DYNLT1/KIF21A/DYNC1LI2/TPM1/MYO1C/MYO9B/DYNC1H1/DNAH11/DCTN6/MYO7B/HOOK3/DCTN2/DCTN1/MYO9A/MYO6/ACTR10/DYNLRB1/DYNLT3/KIF12/KIF3B/KLC1/DCTN4/KIF3C/KIF13A/DNALI1/DNAL4/KLC4/KIF16B/MYO1D/DNAL1/MYO5B/KIF26B/TUBA4A/TUBG2/MYL2/KIF27/TNNT3	-0.00175447501792451
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1837	30/9376	1.02079477408819	PIGT/B3GALT4/DPM2/MPPE1/PGAP3/PIGV	0.0563099692679771
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1837	51/9376	1.00077919028254	PAFAH1B2/PLA2G7/PLD3/PAFAH1B1/LPCAT1/GDPD3/LPCAT2/PLD1/LPCAT4/PLA2G6	0.00275414968647871
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/1837	227/9376	0.989316521142737	MAPK3/EGFR/PIK3R1/PTK2/FOXO3/FOS/HMOX1/AKT3/NFKBIA/PDPK1/MAPK8/MAP2K1/SOS1/GSTT1/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAPK9/BAD/NFE2L2/SOD1/NCF1/NFKB1/SOS2/COX7A2L/MET/MAPK14/MAP2K4/GSTA3/NDUFA13/ABL2/IKBKG/ARAF/PLD1/CHUK/MAP3K5/RAC1/JUN/NCF2/PIK3CD/PIK3R2/NOX4	-0.0804307566565448
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	46/1837	238/9376	0.986482344707072	MAPK3/IL6ST/RPS4Y1/EGFR/PIK3R1/FOS/STAT1/TNFRSF1A/ADAR/NFKBIA/IFNAR1/MAPK8/EIF2AK2/IFIH1/STAT3/PIK3CB/MAPK1/PIK3CA/RELA/MAPK9/IRF3/MAP3K7/JAK1/NFKB1/RPS27L/OAS2/TAB2/NFKBIB/C2/MX2/MAPK14/OAS3/IKBKG/CHUK/JUN/TRAF6/AGTR1/ISG15/PIK3CD/HBEGF/CFB/PIK3R2/CXCL10/TMPRSS2/PRKCG/C8G	-0.10426717665576
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1837	31/9376	0.987865910407923	ACOX1/MLYCD/ALDH3B1/ACOX3/ALDH3B2/ABAT	-0.0334027125336817
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1837	63/9376	0.972185499131607	PLOD3/PIPOX/PLOD2/PRDM2/SMYD3/ASH1L/KMT2C/KMT2E/KMT2A/PHYKPL/DOT1L/SETD1B	-0.109340256628212
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1837	10/9376	1.02079477408819	TST/ETHE1	0.0324758460941857
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1837	32/9376	0.956995100707676	GALM/GAA/GALE/GLB1/B4GALT2/PGM1	-0.120284551709924
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1837	32/9376	0.956995100707676	ACOX1/MCEE/MLYCD/ACOX3/ABAT/ACACB	-0.120284551709924
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	61/1837	323/9376	0.963908378008969	MAPK3/BMPR2/PIM1/CDKN1A/EGFR/PIK3R1/DICER1/TIMP3/TGFB2/RECK/PDGFB/FOXP1/SOX4/TPM1/HMOX1/MARCKS/IRS2/EP300/ERBB3/BMI1/SOCS1/NOTCH2/MAP2K1/PDCD4/SOS1/STAT3/CREBBP/CRK/PIK3CB/MAPK1/SLC7A1/PIK3CA/RAF1/GLS/HDAC5/MDM2/FSCN1/RASSF1/NFKB1/SOS2/APC/CRKL/MCL1/MET/MTOR/BCL2L11/SIRT1/RPS6KA5/MMP9/ITGA5/PRKCE/EFNA1/RPTOR/BCL2L2/RHOA/PIK3CD/PIK3R2/MIR29A/BMF/EZR/PRKCG	-0.325832758953875
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1837	22/9376	0.927995249171079	AOC1/MAOA/ALDH3B1/ALDH3B2	-0.166900314166798
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1837	17/9376	0.900701271254283	GGT7/ADO/GGT5	-0.202272466519031
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1837	17/9376	0.900701271254283	SEPHS2/TXNRD2/TXNRD3	-0.202272466519031
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1837	23/9376	0.887647629641902	CTSA/PRCP/ATP6AP2/AGTR1	-0.266289495534361
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1837	12/9376	0.850662311740156	CD46/NPC1	-0.255512816620936
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1837	52/9376	0.883380092960931	SCARB1/ADCY7/LDLR/HSD3B1/PRKACA/GNAS/ACOT2/ADCY9/ALOX5	-0.416252231732902
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	68/1837	368/9376	0.943125606494521	TUBB2A/PINK1/SQSTM1/MAP1LC3B/RB1CC1/RAB5A/ATF4/TNFRSF1A/ATXN2/OPTN/RAB1A/MAP2K3/XBP1/WIPI1/DNAH11/DCTN6/BECN1/SEC13/CHMP2B/DCTN2/UBQLN1/BAD/DCTN1/ANXA7/ATG13/SOD1/NXT1/ATF6/ACTR10/ANXA11/MATR3/PPP3R1/GPX8/NUP214/PSMA5/ATXN2L/ANG/KLC1/PPP3CB/GPX3/COX7A2L/NUP93/DAXX/DCTN4/PPP3CC/PSMD8/MAPK14/MTOR/UBQLN2/UBQLN4/NDUFA13/ULK2/PIK3C3/NXF1/SPG11/DDIT3/BCL2L1/ATG14/ULK1/ATG2B/DNALI1/DNAL4/KLC4/NXT2/MAP3K5/RAC1/DNAL1/TUBA4A	-0.549426805181551
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	49/1837	268/9376	0.933189252431365	TUBB2A/MAOA/PINK1/DUSP1/TXN/ATF4/CAMK2G/UBC/SLC39A8/SLC39A13/ITPR2/SLC39A6/SLC39A7/MAPK8/UBE2J1/XBP1/SLC39A1/GNAI2/UBE2G2/SLC39A11/SLC39A4/SLC39A9/MAPK9/NFE2L2/UBE2L6/SOD1/ATF6/UBE2G1/PSMA5/SLC11A2/MFN1/SLC39A14/KLC1/COX7A2L/DAXX/PSMD8/NDUFA13/MFN2/PRKACA/GNAL/DDIT3/BCL2L1/GPR37/KLC4/MAP3K5/GNAS/UBB/MAPT/TUBA4A	-0.547754005412416
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	18/1837	103/9376	0.891956598717834	PPP2CB/PABPC1/PPP2R5E/MSI2/PPP2CA/SMG1/SSU72/NXT1/SYMPK/WDR82/PPP2R5A/PELO/PPP2R2D/PPP2R3C/NXF1/NXT2/PAPOLG/PPP2R5B	-0.544239519828852
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1837	59/9376	0.865080317023887	GSTT1/GPX4/GPX8/RRM2B/GPX3/GSR/GSTA3/GCLC/GGT7/GGT5	-0.513152695856059
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1837	31/9376	0.823221592006603	HYI/MCEE/GLUL/CS/AGXT	-0.486635466102132
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1837	13/9376	0.785226749298606	RAD50/LIG4	-0.382496706157696
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/1837	54/9376	0.850662311740156	TST/AMD1/ENOPH1/BCAT1/MAT2B/GCLC/LACC1/SDS/IL4I1	-0.54324420158484
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1837	54/9376	0.850662311740156	RAD51C/ERCC1/REV1/RMI1/ERCC4/TOP3B/POLH/PALB2/SLX1A	-0.54324420158484
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1837	82/9376	0.871410173002111	CMPK1/UPP1/NME3/UCK2/GUSB/NME4/GSTT1/CDA/NME6/TK2/RRM2B/CES2/GSTA3/HPRT1	-0.577292012860125
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1837	37/9376	0.827671438449882	MAOA/FAHD1/ALDH3B1/ALDH3B2/DDC/IL4I1	-0.518431381175529
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1837	43/9376	0.830879467281083	ACOX1/ACSL3/ACSL5/CPT1A/ACSL4/ACOX3/CPT1B	-0.548659972688467
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/1837	105/9376	0.874966949218446	TGFB2/ITGB1/TPM1/ADCY7/DAG1/ITGA3/LMNA/ITGB4/PRKACA/ITGA2/ITGB6/GNAS/ITGA5/SNTB1/CACNA2D3/MYL2/ADCY9/CACNA1C	-0.635974249810954
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1837	61/9376	0.836717027941137	MT1X/FTL/HMOX1/HMOX2/SLC39A4/MT1F/ATP1A4/SLC11A2/ATOX1/ATP7A	-0.631535443463252
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1837	44/9376	0.811995843024694	POLD4/MPG/RFC1/TDG/PARP4/POLB/PARG	-0.617006543665446
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1837	50/9376	0.81663581927055	TGFB2/LRP1/MET/CD36/ITGB2/THBS3/ICAM1/CD40	-0.64170458696711
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	36/1837	205/9376	0.896307606516457	GFPT1/PIK3R1/TGFB2/TGFBR1/CAMK2G/AKT3/CTSD/MAPK8/MPC1/SMAD3/SMAD2/PIK3CB/PIK3CA/RELA/MAPK9/TGFBR2/SP1/NCF1/PPARA/NFKB1/COX7A2L/PDK3/GSR/MAPK14/MTOR/NDUFA13/TBC1D4/MMP9/CD36/RAC1/AGTR1/NCF2/PIK3CD/PIK3R2/PRKCG/CPT1B	-0.740966933826628
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	45/1837	254/9376	0.904247339251347	P2RX4/EGFR/GNAQ/PLCD3/PDGFB/PTGER3/FLT1/ADCY7/CAMK2G/ITPR2/FGFR1/ERBB3/CHRM5/VEGFB/EDNRB/PHKB/STIM2/GNA11/PTK2B/MCOLN1/PPP3R1/PPP3CB/CXCR4/PPP3CC/MET/ADORA2B/NFATC3/PRKACA/SPHK1/GNAL/ITPKC/ORAI1/GNAS/ORAI3/CASQ1/AGTR1/TPCN1/CACNA1A/FGF1/ORAI2/P2RX7/ADCY9/CACNA1C/GNA15/PRKCG	-0.763670509585547
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1837	33/9376	0.773329374309233	OGDH/BCAT1/CS/AGXT/GPT	-0.64386139120461
Human Diseases	Substance dependence	hsa05032	Morphine addiction	15/1837	91/9376	0.841314374248506	GNG12/ADCY7/PDE10A/GRK4/GNAI2/GNB1/GNG10/PRKACA/GNB5/PDE4C/GNAS/PDE4A/CACNA1A/ADCY9/PRKCG	-0.750845661312248
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/1837	57/9376	0.805890611122253	ACOX1/ACSL3/ACSL5/CPT1A/ACSL4/FADS1/TECR/ACOX3/CPT1B	-0.725575582151792
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1837	15/9376	0.680529849392125	AK5/ALPP	-0.611220818474204
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/1837	99/9376	0.824884665929848	PRKAG2/TGFB2/ITGB1/TPM1/DAG1/ITGA3/LMNA/ITGB4/ITGA2/ITGB6/ITGA5/SNTB1/CACNA2D3/EDN1/MYL2/CACNA1C	-0.86461216293408
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1837	35/9376	0.729139124348705	PMM2/GMDS/PFKFB3/FBP1/PFKFB2	-0.792441039444922
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1837	65/9376	0.785226749298606	MGLL/LPIN2/AGPAT1/GPAM/PNPLA2/DGAT1/DGKA/LPL/PNPLA3/LPIN1	-0.857673615515022
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1837	48/9376	0.744329522772637	PIK3R1/AKT3/PIK3CB/PIK3CA/ATP1A4/PIK3CD/PIK3R2	-0.876577414773215
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1837	23/9376	0.665735722231427	GLUL/GLS/GPT	-0.792249114268333
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1837	23/9376	0.665735722231427	PCYOX1/FNTA/PDSS2	-0.792249114268333
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1837	23/9376	0.665735722231427	CA2/GLS/ATP1A4	-0.792249114268333
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1837	102/9376	0.800623352226029	GNAQ/ADCY7/ITPR2/SLC4A2/RAP1B/CA2/ATP1A4/SLC12A2/GNAS/RAC1/CTRB2/RAB3D/RHOA/RAB27B/ADCY9/PRKCG	-0.999365089948043
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1837	43/9376	0.712182400526642	ABCA1/SCARB1/SLC27A1/AGPAT1/CD36/DGAT1	-0.933736393373179
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1837	17/9376	0.600467514169522	CYP39A1/CYP27A1	-0.81385152039921
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1837	17/9376	0.600467514169522	CA2/GLUL	-0.81385152039921
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	25/1837	154/9376	0.828567186759892	UGDH/CMPK1/PTS/QPRT/NME3/RFK/MTHFD2/PMM2/GUSB/NME4/PDXK/PPCS/BCAT1/NME6/NMNAT2/DHRS3/MAT2B/GCLC/AK5/RDH13/EARS2/ALPP/CMPK2/AK9/NMNAT3	-1.05882722178754
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/1837	149/9376	0.82211659658109	MGLL/MAPK3/GNG12/GNAQ/ADCY7/ITPR2/MAPK8/SLC17A8/DAGLB/GNAI2/MAPK1/MAPK9/GNB1/MAPK14/NDUFA13/GNG10/PRKACA/GNB5/FAAH/CACNA1A/ABHD6/ADCY9/CACNA1C/PRKCG	-1.08039271907413
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1837	38/9376	0.671575509268544	IKBKG/ORAI1/CD40/AICDA/IL2RG	-1.00134502248469
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1837	45/9376	0.680529849392125	ABCA1/ABCG1/ABCD1/ABCC10/ABCA5/ABCC3	-1.06036599871309
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1837	88/9376	0.753996139951502	SERPINE1/SERPING1/CD46/CD59/SERPINE2/C2/CLU/ITGB2/C4BPB/SERPINA1/CFB/ITGAM/C8G	-1.14447286210021
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	52/1837	308/9376	0.861709874230288	TUBB2A/CREB5/RB1CC1/GNAQ/CLTB/HIP1/CLTC/CREB3L2/SLC1A3/AP2B1/AP2A2/EP300/MAPK8/WIPI1/DNAH11/DCTN6/CREB3/CREBBP/BECN1/POLR2C/DCTN2/MAPK9/DCTN1/ATG13/SOD1/ACTR10/SP1/GPX8/PSMA5/KLC1/GPX3/COX7A2L/DCTN4/PSMD8/MTOR/NDUFA13/ULK2/PIK3C3/TBP/ATG14/ULK1/ATG2B/MAP3K10/DNALI1/DNAL4/KLC4/MAP3K5/TAF4B/DNAL1/BBC3/TUBA4A/STX1A	-1.21813134556093
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1837	26/9376	0.588920061973954	ACOX1/ACOX3/PLA2G6	-1.03607333271513
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/1837	46/9376	0.665735722231427	PSMB8/PSMA5/PSMB10/PSME4/PSMD8/PSMB9	-1.12178958983131
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	11/1837	78/9376	0.719791186857055	LSM1/PABPC1/CNOT1/ZCCHC7/CNOT6L/DDX6/CNOT2/CNOT7/CNOT4/XRN1/DCP1B	-1.22664153387103
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/1837	34/9376	0.600467514169522	POLR3D/POLR2C/CRCP/POLR3A	-1.15200660508472
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1837	41/9376	0.622435837858651	MAOA/PIPOX/BPGM/AGXT/SDS	-1.19593858214345
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1837	41/9376	0.622435837858651	POLD4/RAD50/RAD51C/TOP3B/PALB2	-1.19593858214345
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	45/1837	275/9376	0.835195724253971	TUBB2A/MAPK3/CREB5/PIK3R1/CAV2/HSPA1B/ATF4/ITPR2/CSNK2A2/CREB3L2/EGR1/LAMC1/MAPK8/CREB3/PIK3CB/MAPK1/PIK3CA/MAPK9/BAD/SOD1/NCF1/PPP3R1/PSMA5/HSPA1A/KLC1/ATF6B/PPP3CB/ATF2/COX7A2L/PPP3CC/PSMD8/MAPK14/CCL5/NDUFA13/PRKACA/DDIT3/KLC4/HSPA6/RAC1/NCF2/PIK3CD/TUBA4A/PIK3R2/CACNA1C/C8G	-1.36922118306973
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1837	28/9376	0.546854343261529	ACOT7/TECR/ACOT2	-1.18533424138001
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1837	21/9376	0.486092749565803	PPCS/BCAT1	-1.16373967570267
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1837	93/9376	0.713458713072389	GNAQ/VAMP2/ADCY7/ITPR2/LYZ/SLC4A2/ATP1A4/PRKACA/SLC12A2/GNAS/PRKG1/ADCY9/PRKCG	-1.3707802887495
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1837	36/9376	0.567108207826771	GAA/GYG1/PGM1/PYGB	-1.28451892873324
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1837	63/9376	0.648123666087738	PTGES/HPGD/GPX4/GGT5/CBR3/PLA2G6/ALOX5/TBXAS1	-1.38324425929502
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1837	37/9376	0.551780958966588	GNAQ/APOL1/ICAM1/PRKCG	-1.34841731644433
Human Diseases	Substance dependence	hsa05034	Alcoholism	29/1837	191/9376	0.774948912265901	MAPK3/MAOA/CREB5/GNG12/FOSB/ATF4/CREB3L2/MAP2K1/GNAI2/SOS1/CREB3/MAPK1/RAF1/SLC29A3/HDAC5/GNB1/SOS2/ATF6B/ATF2/CAMKK2/ADORA2B/GNG10/PRKACA/GNB5/HDAC7/ARAF/GNAS/DDC/CRH	-1.55110630913687
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/1837	90/9376	0.680529849392125	SCARB1/ADCY7/RXRA/SLC4A2/LDLR/CA2/ATP1A4/PRKACA/GNAS/AQP9/ADCY9/ABCC3	-1.50321308063675
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1837	23/9376	0.443823814820951	POLD4/RFC1	-1.3182087330023
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	14/1837	103/9376	0.693744021224982	COL17A1/PRCP/SLC1A5/SLC38A2/COL11A1/ATP1A4/COL4A2/DPP4/COL4A1/CTRB2/COL12A1/COL23A1/SLC7A7/MEP1A	-1.54268196720259
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1837	31/9376	0.493932955203962	H6PD/PGM1/FBP1	-1.39310097323903
NA	NA	hsa04981	Folate transport and metabolism	3/1837	31/9376	0.493932955203962	FOLR1/MTHFR/ABCC3	-1.39310097323903
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1837	46/9376	0.554779768526189	FTL/HMOX1/HMOX2/GUSB/EARS2	-1.49415733019307
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	29/1837	195/9376	0.759052524321985	MAPK3/PIK3R1/AKT3/MAP2K1/PIK3CB/MAPK1/PIK3CA/RAF1/RELA/MAP3K7/HDAC5/NCF1/NFKB1/MAPK14/MTOR/HDAC7/FCGR3A/RAC1/ITGB2/ELANE/AQP9/NCF2/PIK3CD/FPR3/PIK3R2/SELPLG/CLCN5/ITGAM/PRKCG	-1.67833262698896
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	14/1837	108/9376	0.661626242464566	IPO7/XPOT/SEC13/KPNA4/KPNA3/KPNA6/EEF1A1/NXT1/NUP214/XPO7/NUP93/NXF1/NXT2/IPO13	-1.74581766667165
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1837	26/9376	0.392613374649303	SCARB1/LMBRD1	-1.53083871763603
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1837	42/9376	0.486092749565803	AOC1/MAOA/DDC/IL4I1	-1.64762675854707
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1837	28/9376	0.364569562174353	PTS/ALPP	-1.66215309530051
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1837	19/9376	0.268630203707418	OGDH	-1.57517514930463
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1837	29/9376	0.351998197961444	GNB1/PDE6G	-1.72513241630566
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1837	20/9376	0.255198693522047	SOAT1	-1.64586293785982
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/1837	75/9376	0.5444238795137	PYCR1/ALDH18A1/GLUL/BCAT1/CS/MAT2B/SDS/GPT	-1.9552851693089
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/1837	30/9376	0.340264924696062	OGDH/CS	-1.78649028154023
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/1837	39/9376	0.392613374649303	MTHFD2/MAT2B/MTHFR	-1.87619162637487
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1837	31/9376	0.329288636802641	UGDH/GUSB	-1.84633372680748
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/1837	48/9376	0.425331155870078	MCEE/BCAT1/ABAT/IL4I1	-1.97027726940154
NA	NA	hsa04082	Neuroactive ligand signaling	26/1837	199/9376	0.666850857444545	SLC6A2/P2RX4/GNG12/GNAQ/POMC/ADCY7/SLC1A3/CHRM5/TAC3/SLC17A8/GNAI2/GNA11/GNB1/ADORA2B/SLC6A4/SLC1A6/GNG10/PRKACA/GNB5/GNAL/GNAS/P2RY6/HTR3E/ADCY9/PRKCG/P2RY2	-2.34475902904175
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/1837	67/9376	0.457072286905158	GALM/BPGM/PGM1/ALDH3B1/FBP1/ALDH3B2	-2.20146224213073
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1837	68/9376	0.450350635627142	RDH10/CYP26A1/DHRS3/DGAT1/RDH13/CYP26B1	-2.24540840426925
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1837	36/9376	0.283554103913385	UGDH/GUSB	-2.12590844080553
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/1837	36/9376	0.283554103913385	POLD4/RFC1	-2.12590844080553
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1837	26/9376	0.196306687324651	MAFA	-2.02560410255694
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1837	27/9376	0.18903606927559	ABAT	-2.08297561317142
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/1837	47/9376	0.325785566198358	HAGH/ACYP2/ACACB	-2.28724545315721
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1837	30/9376	0.170132462348031	PLA2G6	-2.24719034424228
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1837	41/9376	0.24897433514346	SLC17A8/CACNA1A	-2.37888194601907
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	15/1837	143/9376	0.535381874521777	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/C2/HLA-DMA/TRIM21/HLA-DQB1/HLA-DQA1/FCGR3A/HLA-DMB/ELANE/HLA-DQA2/CD40/C8G	-2.763605790323
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	14/1837	138/9376	0.517794450624443	ATP6V0D1/ATP6V0E1/ATP6AP1/ATP6V1G1/ATP6V1B2/ATP6V1D/ATP6V1E1/LHPP/ATP6V1C1/ATP6V0B/COX7A2L/ATP6V0A1/NDUFA13/ATP6V1E2	-2.81686551473105
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1837	79/9376	0.38764358509678	GSTT1/GSTA3/ALDH3B1/HSD11B1L/ALDH3B2/CBR3	-2.69792421815161
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/1837	87/9376	0.410664564288351	TPM1/ATP1A4/COX7A2L/CACNA2D3/MYL2/SLC9A6/CACNA1C	-2.72596982935835
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1837	73/9376	0.349587251400064	MAOA/GSTT1/GSTA3/ALDH3B1/ALDH3B2	-2.75373604596981
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/1837	116/9376	0.439997747451805	ACOX1/MCEE/H6PD/OGDH/CS/AGXT/FBP1/SDS/ACOX3/GPT	-2.99568827686211
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1837	70/9376	0.291655649739482	GSTT1/GSTA3/HSD11B1L/SULT1A3	-2.93626517942023
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1837	66/9376	0.23199881229277	HSD3B1/HSD11B1L/SULT2B1	-3.09059689283392
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1837	86/9376	0.237394133508881	PRKACA/CACNA1A/HTR3E/CACNA1C	-3.50691189526296
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	13/1837	183/9376	0.362577378774493	REXO2/SBDS/CSNK2A2/EIF6/UTP14C/NXT1/XRN1/NXF1/NXT2/SNORD3A/SNORD3D/SNORD3B-1/SNORD3B-2	-4.29840894580098
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	32/1837	370/9376	0.44142476717327	PGRMC1/P2RX4/ADM/POMC/PTGER3/CSH1/PGRMC2/TSPO/NR3C1/CHRM5/TAC3/EDNRB/THRB/LPAR2/CSH2/ADORA2B/KISS1R/CHRNE/P2RY6/NPB/CHRNB1/AGTR1/FPR3/NPY1R/P2RX7/CSHL1/PTGER4/EDN1/CRH/P2RY2/UCN/LYNX1	-5.41127880492529
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/1837	243/9376	0.231044084670166	HSPA1B/PRPF6/PCBP1/CDC5L/SLU7/HSPA1A/SF3A1/DHX8/U2AF1L4/HSPA6/PRPF40B	-5.99488967129423
Genetic Information Processing	Translation	hsa03010	Ribosome	3/1837	222/9376	0.0689726198708235	RPS4Y1/MRPL28/RPS27L	-6.92973825390325
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1837	449/9376	0.0909394008096381	CAMK2G/GNB1/RGS2/NCALD/PRKACA/GNAL/ANO2/PRKG1	-9.74420882574747