category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	112/2138	250/9376	1.96466230121609	LAPTM4A/LAPTM5/CTSS/CTSB/CD68/CTSD/CLTB/SLC29A1/HGSNAT/TPP1/SLC15A3/VAMP7/IGF2R/ATP6V0D1/AP2B1/CTSA/SLC38A9/CTSO/PSAP/HEXA/LGMN/GUSB/NAGLU/BLOC1S6/SLC17A5/CTBS/ATP6V1G1/LIPA/IDS/LAMP2/GAA/ATP6V1E1/RRAGC/GNS/GNPTG/VAMP8/VPS35/NAGA/AP2A2/ARSG/LAMTOR3/ATP6V1A/SLC29A3/OSBPL1A/ATP6V1H/SUMF1/DMXL2/VPS13C/ASAH1/SLC11A1/ENTPD4/CTSH/AP1S2/ROGDI/ATP6V1D/ATP6V1C1/AP5S1/TELO2/GGA3/AGA/ACP5/ATP6AP1/ACP2/MCOLN1/BLOC1S4/ATP6V0E1/MLST8/GALNS/BLOC1S2/SPG11/CLCN7/CTSC/GNPTAB/PPT1/NAGPA/NPC1/RRAGD/CTSL/MTOR/STX17/GGA1/PIKFYVE/CTSZ/AP4E1/ABCA5/TMEM175/AP5M1/SLC15A4/SGSH/TLR3/ATP6V0A1/PLA2G15/DTNBP1/PPT2/HYAL4/OSBPL2/CD164/TPCN1/MFSD8/AP5Z1/FIG4/VPS11/BLOC1S3/DEPTOR/PLEKHM1/VPS13A/RPTOR/SMPD1/WDR7/TFE3/MITF/ZFYVE26	8.40205031783838
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	103/2138	224/9376	2.01650407590539	HLA-DRA/HLA-B/CDKN2A/HLA-DPA1/HLA-DRB1/HLA-DPB1/CDKN1A/HLA-DQA1/HLA-DQB1/HLA-DMA/ITGB2/HLA-A/CREB5/ANAPC13/HLA-DMB/ETS2/SPI1/NRP1/NFKBIA/TGFB2/TGFBR1/TLN2/EP300/HLA-DQA2/VAC14/SMAD4/CCNE1/HLA-DRB5/MAPK3/PIK3R1/ATF6B/XIAP/CD4/CREBBP/ANAPC16/BAX/PPP3R1/ICAM1/NFKB1/CDC23/CREB3L4/CREB3L2/JAK1/NFYB/TBP/HLA-F/MMP7/DLG1/PPP3CA/SMAD2/CRTC3/EGR2/NFATC3/MAP2K1/ATM/RB1/ZFP36/ANAPC5/CD40/MAP3K1/GPS2/MAPK1/E2F2/SRF/PPP3CB/IKBKG/PIK3CA/NFKB2/CREB1/ELK4/MAP3K3/ATF2/MAD2L1/CCNE2/KRAS/IL2RG/ANAPC7/ATR/ADCY7/IKBKB/MAP2K4/IL2RB/ITGAL/CHUK/CRTC2/PIK3R2/CDKN2B/TGFB1/ADCY6/TRRAP/TNF/SMAD3/ADCY9/MAPK8/EGR1/PIK3R3/STAT5A/FOS/NFATC1/JAK3/FOSL1/PRKACB/CRTC1	8.36864850134557
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	57/2138	109/9376	2.29328618875567	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/EBI3/HLA-DQA1/HLA-DQB1/HLA-DMA/IL1RAP/HLA-DMB/RXRA/IL6ST/NFKBIA/TGFBR1/GATA3/HLA-DQA2/SMAD4/HLA-DRB5/MAPK3/IL1B/CD4/AHR/STAT6/PPP3R1/HIF1A/NFKB1/IFNGR1/RXRB/JAK1/PPP3CA/SMAD2/NFATC3/RUNX1/MAPK1/PPP3CB/IKBKG/MTOR/IL2RG/NFKBIE/IL27/IKBKB/IL2RB/TYK2/CHUK/TGFB1/IL6R/SMAD3/MAPK8/RARA/STAT5A/IL4R/LAT/PLCG1/FOS/NFATC1/JAK3/JAK2	7.38105610314193
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	72/2138	163/9376	1.93711226018238	CDKN1A/CREB5/MAP2K3/NFKBIA/TGFB2/TGFBR1/EP300/PCNA/MMP9/SMAD4/CCNE1/MAPK3/PIK3R1/ATF6B/CREBBP/STAT6/SOS1/BAX/YWHAZ/RAF1/NFKB1/CREB3L4/CREB3L2/JAK1/MAP3K7/DDB2/EGR2/NFATC3/MAP2K1/FADD/RB1/IFNAR1/ATP6AP1/EGR3/MAP3K1/MAPK1/E2F2/MAP2K7/IRAK4/IKBKG/PIK3CA/TAB2/CREB1/ATF2/DDB1/CCNE2/KRAS/ARAF/TRAF3/TLR4/IKBKB/MAP2K4/TYK2/IKBKE/CHUK/TLR3/STAT4/PIK3R2/BID/MAVS/TGFB1/TRAF6/IFIH1/TNF/SMAD3/MAPK8/PIK3R3/STAT5A/FOS/NFATC1/JAK3/JAK2	6.55941465248676
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	57/2138	119/9376	2.10057306365016	CREB5/CXCL2/MAP2K3/NFKBIA/CXCL3/ADAM17/MMP9/MAPK3/PIK3R1/ATF6B/XIAP/IL1B/TNFAIP3/ICAM1/NFKB1/CREB3L4/CREB3L2/MAP3K5/CCL20/MAP3K7/MAP2K1/FADD/IRF1/MAPK1/RPS6KA5/CFLAR/CEBPB/MAP2K7/RIPK1/IKBKG/PIK3CA/CYLD/CASP7/TAB2/BIRC2/CXCL10/CREB1/ATF2/RHBDF1/TRAF3/BIRC3/PTGS2/CCL5/IKBKB/MAP2K4/CHUK/BCL3/TNFRSF1B/PIK3R2/DAB2IP/TNF/TAB3/MAPK8/RHBDF2/PIK3R3/MLKL/FOS	6.5665525993983
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	69/2138	157/9376	1.9273444435838	HLA-B/CDKN2A/SERPINE1/CDKN1A/IGFBP3/GADD45A/HLA-A/FOXO3/ZFP36L1/MAP2K3/ITPR2/TGFB2/TGFBR1/FOXO1/RBBP4/TSC1/RBL2/CCNE1/MDM2/MAPK3/PIK3R1/HIPK3/RAD9A/HIPK1/RAF1/PPP3R1/RAD1/HIPK2/NFKB1/ITPR3/CDK1/HLA-F/TRPM7/CAPN2/PPP3CA/SMAD2/NFATC3/MAP2K1/ATM/FOXM1/RB1/RRAS2/MAPK1/E2F2/RBL1/TRAF3IP2/ZFP36L2/PPP3CB/PPP1CC/MCU/PIK3CA/RHEB/MTOR/CCNE2/KRAS/ATR/SQSTM1/FBXW11/PIK3R2/CDKN2B/MRAS/TGFB1/SIRT1/LIN54/RASSF5/LIN52/SMAD3/PIK3R3/NFATC1	6.36838326008442
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	61/2138	133/9376	2.01135204709623	CDKN1A/GADD45A/FOXO3/GABARAP/PRKAG2/CCNG2/FBXO32/TGFB2/TGFBR1/EP300/FOXO1/IRS2/USP7/HOMER3/GABARAPL2/BCL2L11/BCL6/PRKAB2/RBL2/SMAD4/MDM2/MAPK3/PIK3R1/PDPK1/CREBBP/SOS1/RAF1/IGF1R/CDKN1B/CAT/MAP2K1/SGK1/ATM/HOMER1/GABARAPL1/MAPK1/PLK3/PIK3CA/PCK2/KRAS/STK11/ARAF/PRKAA1/IKBKB/CHUK/EGFR/CDKN2D/TNFSF10/PIK3R2/CDKN2B/PLK4/TGFB1/SIRT1/PRKAB1/SGK3/NLK/KLF2/SMAD3/MAPK8/PIK3R3/IL7R	6.38413263292494
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	47/2138	93/9376	2.21628091775049	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DMB/MAML2/NFKBIA/NOTCH2/GATA3/HLA-DQA2/HLA-DRB5/MAPK3/CD4/RBPJ/STAT6/PPP3R1/NFKB1/IFNGR1/JAK1/PPP3CA/NFATC3/MAML1/MAPK1/JAG2/PPP3CB/IKBKG/IL2RG/NFKBIE/IKBKB/IL2RB/TYK2/CHUK/STAT4/NOTCH1/MAPK8/STAT5A/IL4R/LAT/DLL1/PLCG1/FOS/NFATC1/JAK3/JAK2	6.40636076142162
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	62/2138	138/9376	1.97025528395765	FN1/MAP2K3/SKAP2/GNAQ/VAV3/NFKBIA/MAPK3/PIK3R1/IL1B/CD4/PTK2/PKN2/IL18/WIPF2/LCP2/NFKB1/ARPC2/RPS6KA3/MAP3K7/CRK/NFATC3/MAP2K1/FCGR2A/ARF6/ARHGEF7/MAPK1/MAP2K7/VAV2/GIT2/CRKL/ITGB1/PYCARD/IRAK4/IKBKG/PIK3CA/TAB2/WAS/PIP5K1A/BAIAP2/ARHGEF12/WASL/RAC2/CASP1/WIPF1/TLR4/IKBKB/MAP2K4/WASF2/CHUK/ITGA5/PIK3R2/TRAF6/TNF/MAPK8/ELMO2/PIK3R3/NLRP3/VAV1/LAT/PLCG1/FOS/NFATC1	6.24046253267703
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	32/2138	54/9376	2.59875965769324	RPA1/FANCE/BRCA1/REV1/RMI1/RPA2/BRCA2/USP1/TELO2/FANCD2/MUS81/FANCI/RAD51/BLM/FANCL/FANCA/ATR/WDR48/FANCG/RMI2/TOP3A/ERCC4/UBE2T/FANCM/PALB2/FANCC/POLH/BRIP1/EME1/RPA4/SLX4/SLX1A	6.40332744562279
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	63/2138	142/9376	1.94563828245431	TYROBP/TREM2/LILRB3/FCGR3A/SPI1/ITPR2/NFKBIA/TGFB2/TGFBR1/NCF2/SYK/BLNK/CSF1R/LILRB4/MAPK3/PIK3R1/IL1B/FCGR1A/FOSL2/PPP3R1/LCP2/NFKB1/IFNGR1/ITPR3/JAK1/MAP3K7/PPP3CA/MAP2K1/FCGR2A/IFNAR1/TMEM64/ACP5/OSCAR/MAPK1/ATP2A2/MAP2K7/PPP3CB/IKBKG/PIK3CA/CYLD/NFKB2/TAB2/CREB1/SIRPA/SQSTM1/IKBKB/TYK2/CHUK/LILRB1/BTK/PIK3R2/TGFB1/LILRB2/JUND/TRAF6/TNF/MAPK8/PIK3R3/FCGR3B/FOS/MITF/NFATC1/FOSL1	6.17098487340053
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	53/2138	112/9376	2.07523720432981	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/PPIF/HLA-DMA/ITGA6/LAMC1/HLA-DMB/MAP2K3/LY96/NFKBIA/TGFB2/LAMA5/IL10RB/HLA-DQA2/HLA-DRB5/MAPK3/NOS2/XIAP/PDPK1/LAMC2/IL10RA/NFKB1/IFNGR1/JAK1/MAP3K7/CD40/MAPK1/ITGB1/HSPA6/IRAK4/IKBKG/ALOX5/TAB2/BIRC2/LAMB4/BIRC7/TLR4/BIRC3/IKBKB/TYK2/CHUK/TGFB1/PIK3R5/TRAF6/LAMB3/TNF/MAPK8/HSPA1B/JAK2	6.22148732113683
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	41/2138	78/9376	2.30514979252117	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/EEF1A1/HLA-DQA1/HLA-DQB1/HLA-DMA/ITGB2/FCGR3A/HLA-DMB/NFKBIA/TGFB2/NCF2/HLA-DQA2/HLA-DRB5/MAPK3/NOS2/IL1B/FCGR1A/CYBB/NFKB1/IFNGR1/JAK1/MAP3K7/FCGR2A/ITGAM/MAPK1/PTPN6/ITGB1/IRAK4/TAB2/TLR4/PTGS2/TGFB1/TRAF6/TNF/EEF1A2/FCGR3B/FOS/JAK2	6.290614741585
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	46/2138	93/9376	2.16912600460686	CDKN1A/FN1/GADD45A/ITGA6/COL4A1/LAMC1/RXRA/COL4A2/NFKBIA/LAMA5/CCNE1/PIK3R1/NOS2/XIAP/PTK2/CKS2/BAX/CKS1B/LAMC2/NFKB1/RXRB/DDB2/CDKN1B/RB1/E2F2/ITGB1/IKBKG/PIK3CA/BIRC2/ITGAV/CCNE2/ITGA3/LAMB4/BIRC7/ITGA2/TRAF3/BIRC3/PTGS2/IKBKB/CHUK/PIK3R2/CDKN2B/TRAF6/LAMB3/PIK3R3/ITGA2B	6.15798772451638
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	71/2138	169/9376	1.84238989045782	CTSB/GABARAP/CTSD/DAPK1/IRS2/GABARAPL2/TSC1/STX7/MAPK3/PIK3R1/LAMP2/RRAGC/PDPK1/VAMP8/RAF1/HIF1A/IGF1R/PPP2CA/MAP3K7/RAB1A/MAP2K1/PPP2CB/WDR45B/RPS6KB1/GABARAPL1/BIRC6/RRAS2/SUPT20H/MAPK1/CFLAR/MLST8/PIK3CA/ATG13/RHEB/NBR1/RRAGD/CTSL/MTOR/STX17/KRAS/STK11/OPTN/ATG16L2/EIF2AK3/PRKAA1/SQSTM1/CAMKK2/ATG14/C9orf72/ATG7/PIK3R2/MAP1LC3B/WDFY3/MRAS/PIK3C3/EPG5/ATG16L1/VPS11/ULK2/DEPTOR/TRAF6/PLEKHM1/ATG2B/RPTOR/ULK1/MAPK8/MTMR3/PIK3R3/TP53INP2/AMBRA1/PRKACB	6.00589349228825
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	120/2138	333/9376	1.58032681886751	SPP1/HLA-B/CDKN1A/FN1/HLA-A/CREB5/ITGA6/COL4A1/LAMC1/TCF7L2/COL4A2/PARD6G/MAML2/HES4/WNT7A/EP300/NOTCH2/FOXO1/LAMA5/ATP6V0D1/ITGB4/AXIN2/FZD1/CHD4/TSC1/RBL2/ATP6V1G1/CCNE1/MDM2/MAPK3/PIK3R1/ATP6V1E1/ITGB6/CREBBP/PTK2/RBPJ/ATP6V1A/SOS1/BAX/ATP6V1H/RAF1/LAMC2/NFKB1/CREB3L4/CREB3L2/JAK1/PSEN1/PPP2CA/TBP/UBR4/HLA-F/UBE3A/CDKN1B/DLG1/MAP2K1/FZD6/ATM/PTGER4/MAML1/PPP2CB/FADD/ATP6V1D/ATP6V1C1/RB1/IFNAR1/RPS6KB1/PPP2R5E/ATP6AP1/TCF7/IRF1/MAPK1/RBL1/ATP6V0E1/MX2/ITGB1/HES2/IKBKG/PIK3CA/CREB1/ITGAV/RHEB/MTOR/LFNG/TCF7L1/CCNE2/KRAS/COL9A3/ITGA3/APC/LAMB4/FZD7/ITGA2/ATR/TRAF3/PTGS2/IKBKB/WNT6/TYK2/IKBKE/CHUK/EGFR/NFX1/TLR3/ATP6V0A1/ITGA5/PIK3R2/NOTCH1/LLGL2/WNT5B/OASL/FZD3/LAMB3/TNF/FZD8/PIK3R3/WNT11/ITGA2B/VWF/PRKACB/VEGFA	5.86028438595966
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	24/2138	36/9376	2.9236046149049	RPA1/MCM3/PCNA/RFC3/RFC1/RFC2/RPA2/MCM4/LIG1/POLE3/PRIM2/POLD4/MCM2/POLE/MCM5/RNASEH2B/POLA1/MCM6/FEN1/POLD1/PRIM1/POLE2/DNA2/RPA4	6.28454473260361
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	67/2138	158/9376	1.85963458099963	CDKN2A/CDKN1A/GADD45A/ANAPC13/MCM3/YWHAG/TGFB2/EP300/PCNA/RBL2/SMAD4/CCNE1/MDM2/PKMYT1/PDS5A/CREBBP/ANAPC16/STAG1/TFDP2/YWHAZ/MCM4/TTK/CDC23/ORC6/CDT1/PPP2CA/CDK1/MAD2L2/STAG2/CDKN1B/SMAD2/MCM2/ATM/PPP2CB/FBXO5/RB1/ANAPC5/PPP2R5E/CUL1/E2F2/RBL1/NIPBL/MCM5/NDC80/ESCO1/MCM6/MAD2L1/ESCO2/CCNE2/CDCA5/SMC1B/ANAPC7/ATR/SMC3/CDKN2D/MAU2/DDX11/ORC5/CDKN2B/TGFB1/TICRR/CDC7/RBX1/BUB1/SMAD3/MTBP/DBF4B	5.9224890796627
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	42/2138	83/9376	2.21912157516878	EP300/JARID2/BMI1/RBBP4/USP7/RBBP7/PHC2/SUZ12/CREBBP/DCAF7/USP16/CBX3/MGA/LCOR/EZH2/L3MBTL3/MTF2/ASXL2/L3MBTL2/KDM2A/FBRSL1/HCFC1/YAF2/FOXK2/TEX10/KDM2B/CBX4/OGT/PHC1/SFMBT1/PHC3/UBE2D4/E2F6/FOXK1/SCML1/USP45/BCOR/L3MBTL1/MBD5/SFMBT2/CBX8/CBX2	6.0630101326914
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	95/2138	250/9376	1.66645463049579	HLA-B/HLA-A/CXCR4/CLTB/PARD6G/SH3KBP1/IST1/TGFBR1/IGF2R/ASAP3/AP2B1/RAB5B/CHMP3/VPS4B/VPS36/MDM2/SH3GL1/VPS35/AP2A2/WIPF2/GRK4/CHMP4C/ARFGAP2/RAB11B/PDCD6IP/HGS/STAMBP/ARPC2/IGF1R/TSG101/RABEP1/HLA-F/SNX1/IQSEC1/RAB5A/SMAD2/VPS37B/CHMP1A/CHMP1B/TFRC/ARF6/GBF1/MVB12A/NEDD4/ASAP1/DNM2/VPS4A/PLD1/USP8/SNX5/GIT2/CYTH2/SMAP2/CHMP6/HSPA6/AGAP3/ARFGAP1/PIP5K1A/FGFR3/NEDD4L/RUFY1/ARAP1/WASL/STAM/IL2RG/EHD3/CYTH3/WIPF1/GIT1/ARRB2/VPS25/IL2RB/CAPZA1/ACAP3/FOLR1/EGFR/CYTH1/VPS45/RAB11FIP1/ZFYVE27/TRAF6/SMAD3/CXCR2/CYTH4/PIP5KL1/ARAP2/DNAJC6/HSPA1B/ARRB1/RAB11FIP3/AGAP6/SH3GL3/ACAP1/EPN3/MVB12B	5.80471044936966
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	74/2138	181/9376	1.79292879698588	HLA-DRA/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/FCER1G/HLA-DQA1/HLA-DQB1/HLA-DMA/ITGB2/FCGR3A/HLA-DMB/CTSD/LSP1/TGFB2/EP300/KSR1/ATP6V0D1/IL10RB/HLA-DQA2/SYK/CAMK2G/RAB5B/ITGAX/HLA-DRB5/MAPK3/LAMP2/NOS2/IL1B/CREBBP/FCGR1A/IL18/BAX/ATP6V1H/RAF1/PPP3R1/IL10RA/NFKB1/IFNGR1/JAK1/NFYB/NFYC/PPP3CA/RAB5A/MRC2/FCGR2A/CEBPG/ITGAM/FADD/CORO1A/ATP6AP1/MAPK1/CEBPB/PLK3/PPP3CB/IRAK4/CREB1/ARHGEF12/TLR4/ATP6V0A1/BID/CAMK2D/PIK3C3/TGFB1/NFYA/TRAF6/TNF/MAPK8/PLA2R1/FCGR3B/SPHK2/CARD9/JAK2	5.85433823744277
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	109/2138	300/9376	1.59336451512317	IGF2/RASGRF2/GADD45A/IL1RAP/ERBB3/DUSP2/MAP2K3/TGFB2/TGFBR1/MAP3K2/DUSP4/RASA1/EFNA1/CSF1R/MAPK3/EREG/GNG12/IL1B/LAMTOR3/SOS1/RAF1/PPP3R1/ERBB2/RASGRF1/NFKB1/TAOK1/RPS6KA3/IGF1R/MAP3K5/RAPGEF2/MAP3K7/PPM1B/PPP3CA/CRK/PAK2/NFATC3/MAP2K1/RRAS2/TAOK3/MAP3K1/MAPK1/RPS6KA5/MAP2K7/SRF/PPP5C/PPP3CB/CRKL/HSPA6/STK3/IRAK4/IKBKG/MAP3K11/NFKB2/TAB2/NF1/MAPK8IP2/ELK4/MAP3K3/ATF2/PPM1A/FGFR3/DUSP3/DUSP10/MAPT/KRAS/MAP4K3/RAC2/EFNA5/ARAF/DUSP7/PTPRR/ARRB2/RAP1B/DUSP1/IKBKB/MAP2K4/CHUK/EGFR/RASA2/PDGFA/DUSP8/MET/MRAS/TGFB1/MAPK8IP3/RASGRP3/PDGFB/NLK/JUND/MAPKAPK3/TAOK2/DUSP9/TRAF6/MAPK7/TNF/MAP3K9/MAPK8/CACNA2D3/ANGPT2/FOS/EFNA2/HSPA1B/ARRB1/NFATC1/HSPB1/PRKACB/CACNA1G/NRTN/VEGFA	5.67695110519151
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	39/2138	77/9376	2.22118012950567	CDKN2A/CDKN1A/GADD45A/TGFB2/TGFBR1/SMAD4/MAPK3/PIK3R1/RALGDS/BAX/RAF1/ERBB2/NFKB1/JAK1/DDB2/BRCA2/SMAD2/MAP2K1/RB1/RPS6KB1/MAPK1/E2F2/PLD1/IKBKG/PIK3CA/RAD51/MTOR/KRAS/RAC2/ARAF/IKBKB/CHUK/EGFR/PIK3R2/TGFB1/SMAD3/MAPK8/PIK3R3/VEGFA	5.84772804420966
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	58/2138	137/9376	1.85659563136296	CTSS/CTSB/GADD45A/CTSD/BCL2A1/ITPR2/NFKBIA/CSF2RB/CTSO/BCL2L11/PARP4/CASP2/MAPK3/PIK3R1/XIAP/PDPK1/BAX/RAF1/NFKB1/ITPR3/MAP3K5/PMAIP1/CAPN2/CTSH/PARP2/MAP2K1/ATM/FADD/MAPK1/CFLAR/RIPK1/BBC3/DFFB/IKBKG/PIK3CA/CASP7/BIRC2/CTSC/CTSL/DIABLO/KRAS/CTSZ/EIF2AK3/BIRC3/IKBKB/TNFRSF10A/CHUK/TNFSF10/PIK3R2/BID/TNFRSF10B/DAB2IP/TNF/MAPK8/MCL1/TUBA4A/PIK3R3/FOS	5.48913427286773
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	75/2138	196/9376	1.67808938355511	HLA-B/CDKN1A/CCR1/HLA-A/CXCL2/TCF7L2/IL6ST/ITPR2/NFKBIA/RCAN1/CXCL3/EP300/SYK/MAPK3/PIK3R1/GNG12/CREBBP/BAX/CLEC2B/RAF1/PPP3R1/ICAM1/HIF1A/NFKB1/IFNGR1/ITPR3/JAK1/GNG4/HLA-F/CD86/PPP3CA/NFATC3/MAP2K1/FADD/RB1/ZFP36/IFNAR1/TCF7/MAPK1/E2F2/MAP2K7/PPP3CB/IKBKG/PIK3CA/CREB1/HCK/MTOR/TCF7L1/KRAS/PREX1/TRAF3/PTGS2/IKBKB/MAP2K4/TYK2/ATG14/IKBKE/CHUK/TLR3/PIK3R2/BID/MAP1LC3B/PIK3C3/PIK3R5/PDGFB/GNG10/MAPK8/PIK3R3/ANGPT2/PLCG1/GNGT1/FOS/NFATC1/JAK2/VEGFA	5.21403376528306
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	76/2138	204/9376	1.63377904950568	TIMP3/CDKN1A/IGF2/FN1/ERBB3/VAV3/TIAM1/ITPR2/WNT7A/TGFB2/CD44/CAMK2G/FZD1/MMP9/MDM2/MAPK3/PIK3R1/PDPK1/HCLS1/PTK2/SOS1/RAF1/ERBB2/HIF1A/ITPR3/IGF1R/SMAD2/MAP2K1/FZD6/SDC4/HBEGF/RPS6KB1/RRAS2/MAPK1/PTPN6/VAV2/GPC3/FRS2/ITGB1/PPP1CC/MSN/PLAU/GAB1/PIK3CA/SLC9A1/ITGAV/TFAP4/CTSL/MTOR/ARHGEF12/PPP1R12B/KRAS/ARAF/FZD7/ITGA2/TLR4/WNT6/EGFR/ITGA5/PIK3R2/PLCE1/MET/CAMK2D/MRAS/TGFB1/SDC2/WNT5B/FZD3/TNF/FZD8/PIK3R3/WNT11/VAV1/PLCG1/PRKACB/VEGFA	4.97394683349165
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	33/2138	68/9376	2.12821218290871	PIM1/TCF7L2/SPI1/BCL2A1/CEBPA/CSF1R/JUP/MAPK3/PIK3R1/FCGR1A/SOS1/RAF1/NFKB1/PPARD/MAP2K1/ITGAM/RPS6KB1/RUNX1/TCF7/MAPK1/PER2/IKBKG/PIK3CA/MTOR/TCF7L1/KRAS/ARAF/IKBKB/CHUK/PIK3R2/RARA/PIK3R3/STAT5A	5.07454669790515
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	82/2138	227/9376	1.58415580455199	HLA-B/CDKN2A/CDKN1A/TAPBPL/CCR1/HLA-A/CREB5/CXCR4/GNAQ/AKAP13/ITPR2/NFKBIA/CCL3/TAPBP/IL10RB/TSC1/MDM2/SP1/MAPK3/PIK3R1/ATF6B/GNG12/IL1B/PTK2/SOS1/BAX/GNA11/RAF1/PPP3R1/IL10RA/NFKB1/CREB3L4/ITPR3/CREB3L2/JAK1/GNG4/HLA-F/GNA13/PPP3CA/CRK/NFATC3/MAP2K1/PTGER4/FADD/RB1/RPS6KB1/MAPK1/E2F2/RIPK1/PPP3CB/CRKL/IKBKG/PIK3CA/CREB1/ITGAV/RHEB/ATF2/MTOR/ARHGEF12/KRAS/RAC2/ADCY7/PTGS2/CCL5/IKBKB/CHUK/EGFR/PIK3R2/BID/PLCB1/ADCY6/IL6R/GNG10/TNF/CXCR2/ADCY9/PIK3R3/ARHGEF11/GNGT1/NFATC1/PRKACB/VEGFA	4.84211400582435
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	40/2138	91/9376	1.92765139444279	LILRB3/DAPP1/VAV3/NFKBIA/SYK/BLNK/LILRB4/MAPK3/PIK3R1/SOS1/RAF1/PPP3R1/NFKB1/PPP3CA/NFATC3/MAP2K1/MAPK1/PTPN6/VAV2/CD22/PPP3CB/PIK3AP1/IKBKG/PIK3CA/KRAS/RAC2/CD72/NFKBIE/INPPL1/IKBKB/CHUK/LILRB1/BTK/PIK3R2/LILRB2/RASGRP3/PIK3R3/VAV1/FOS/NFATC1	4.83275460263688
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	35/2138	77/9376	1.9933667828897	CDKN2A/CDKN1A/GADD45A/NFKBIA/TGFB2/TGFBR1/SMAD4/MDM2/MAPK3/PIK3R1/SOS1/BAX/RAF1/NFKB1/DDB2/CDKN1B/CRK/MAP2K1/RB1/RUNX1/MAPK1/E2F2/CRKL/IKBKG/PIK3CA/KRAS/ARAF/IKBKB/CHUK/PIK3R2/BCR/TGFB1/SMAD3/PIK3R3/STAT5A	4.75682387400284
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	74/2138	205/9376	1.58302493782655	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/CDKN1A/TAPBPL/HLA-DQA1/HLA-DQB1/HLA-DMA/GADD45A/HLA-A/HLA-DMB/MAP2K3/NFKBIA/TAPBP/USP7/HLA-DQA2/SYK/CD44/BCL2L11/BLNK/VIM/CCNE1/MDM2/HLA-DRB5/PIK3R1/RBPJ/BAX/TNFAIP3/ICAM1/NFKB1/JAK1/HLA-F/NCOR2/MAP3K7/DDB2/CDKN1B/FADD/RB1/IFNAR1/NEDD4/CD40/E2F2/MAP2K7/RIPK1/IRAK4/IKBKG/PIK3CA/NFKB2/TAB2/CXCL10/CCNE2/SIN3A/OAS2/NFKBIE/TRAF3/IKBKB/MAP2K4/ITGAL/TYK2/IKBKE/CHUK/CD58/BTK/PIK3R2/BID/MAVS/ENTPD1/TRAF6/TNF/MAPK8/PIK3R3/JAK3	4.58707577456712
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	44/2138	105/9376	1.83769432936879	FCER1G/LSP1/ITPR2/NFKBIA/KSR1/SYK/MDM2/MAPK3/PIK3R1/IL1B/RAF1/PPP3R1/NFKB1/ITPR3/PPP3CA/EGR2/NFATC3/RRAS2/EGR3/IRF1/MAPK1/PLK3/PPP3CB/PYCARD/IKBKG/PIK3CA/CYLD/NFKB2/ARHGEF12/KRAS/CASP1/PTGS2/IKBKB/IKBKE/CHUK/BCL3/PIK3R2/MRAS/TNF/MAPK8/PIK3R3/NLRP3/CARD9/NFATC1	4.69134242710387
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	77/2138	216/9376	1.56331635658109	VLDLR/CXCL2/RXRA/CD36/OLR1/MAP2K3/VAV3/LY96/NFKBIA/CXCL3/ABCG1/CCL3/NCF2/CAMK2G/MMP9/ABCA1/MAPK3/PIK3R1/MIB1/PDPK1/IL1B/PTK2/IL18/BAX/PPP3R1/ICAM1/CYBB/NFKB1/RXRB/MAP3K5/MAP3K7/PPP3CA/NFATC3/CD40/MAPK1/MAP2K7/VAV2/PPP3CB/NFE2L2/HSPA6/PYCARD/IRAK4/IKBKG/PIK3CA/CASP7/TAB2/POU2F1/KRAS/CASP1/EIF2AK3/TRAF3/TLR4/CCL5/RAP1B/IKBKB/MAP2K4/TNFRSF10A/IKBKE/POU2F2/CHUK/TNFSF10/PIK3R2/BID/CAMK2D/TNFRSF10B/PLCB1/TRAF6/TNF/MAPK8/PIK3R3/NLRP3/VAV1/PLCG1/FOS/HSPA1B/NFATC1/JAK2	4.55209901117405
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	39/2138	90/9376	1.90034299968818	CREB5/FOXO3/PRKAG2/SESN1/FOXO1/IRS2/TSC1/PRKAB2/PIK3R1/ATF6B/BAX/NFKB1/CREB3L4/IGF1R/CREB3L2/CAT/RPS6KB1/PIK3CA/CREB1/ATG13/RHEB/ATF2/MTOR/KRAS/STK11/PRKAA1/ADCY7/CAMKK2/EHMT2/SESN2/PIK3R2/SIRT1/PRKAB1/ADCY6/RPTOR/ULK1/ADCY9/PIK3R3/PRKACB	4.66439269491944
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	39/2138	90/9376	1.90034299968818	BATF3/MAP2K3/NFKBIA/MAPK3/PIK3R1/CD4/RAF1/PPP3R1/HIF1A/NFKB1/IFNGR1/CD274/JAK1/PPP3CA/NFATC3/MAP2K1/CSNK2A2/RPS6KB1/MAPK1/PTPN6/PPP3CB/IKBKG/PIK3CA/MAP3K3/MTOR/KRAS/NFKBIE/TLR4/IKBKB/CHUK/EGFR/PIK3R2/TRAF6/PIK3R3/LAT/PLCG1/FOS/NFATC1/JAK2	4.66439269491944
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	59/2138	155/9376	1.66928392528441	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/HLA-DQA1/HLA-DQB1/HLA-DMA/ITGB2/MSR1/HLA-A/FCGR3A/HLA-DMB/CD36/OLR1/NCF2/ATP6V0D1/HLA-DQA2/RAB5B/ATP6V1G1/STX7/HLA-DRB5/LAMP2/ATP6V1E1/DYNC1I2/FCGR1A/ATP6V1A/ATP6V1H/HGS/CYBB/HLA-F/RAB5A/TFRC/MRC2/FCGR2A/MARCO/ITGAM/ATP6V1D/ATP6V1C1/DYNC1LI2/CORO1A/ATP6AP1/ATP6V0E1/ITGB1/STX12/ITGAV/CTSL/PIKFYVE/SCARB1/ITGA2/TLR4/ATP6V0A1/ITGA5/PIK3C3/RILP/PLA2R1/TUBA4A/FCGR3B	4.56633144821197
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	38/2138	87/9376	1.9154650925239	CDKN1A/GADD45A/TCF7L2/TGFB2/TGFBR1/AXIN2/BCL2L11/SMAD4/MAPK3/PIK3R1/EREG/RALGDS/SOS1/BAX/RAF1/PMAIP1/DDB2/SMAD2/MAP2K1/RPS6KB1/TCF7/MAPK1/BBC3/PIK3CA/MSH2/MTOR/TCF7L1/KRAS/RAC2/ARAF/APC/EGFR/PIK3R2/TGFB1/SMAD3/MAPK8/PIK3R3/FOS	4.66226691256723
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	41/2138	98/9376	1.83471105935358	FCGR3A/VAV3/MARCKS/ASAP3/LIMK2/SYK/PTPRC/MAPK3/PIK3R1/FCGR1A/SCIN/RAF1/ARPC2/CRK/MAP2K1/FCGR2A/ARF6/ASAP1/RPS6KB1/DNM2/MAPK1/PLD1/VAV2/CRKL/PIK3CA/HCK/PRKCE/WAS/PIP5K1A/RAC2/INPPL1/WASF2/PIK3R2/WASF1/PIK3R3/PLA2G6/VAV1/LAT/FCGR3B/PLCG1/SPHK2	4.51442269592547
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	40/2138	95/9376	1.84648712520309	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/ITGB2/CXCL2/HLA-DMB/TGFB2/CXCL3/CCL3/ATP6V0D1/HLA-DQA2/TNFSF13B/ATP6V1G1/HLA-DRB5/ATP6V1E1/IL1B/IL18/ATP6V1A/ATP6V1H/ICAM1/CCL20/CD86/ATP6V1D/ATP6V1C1/ACP5/ATP6AP1/ATP6V0E1/CTSL/TLR4/CCL5/ITGAL/ATP6V0A1/TGFB1/TNF/FOS/VEGFA	4.50676561943506
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	55/2138	144/9376	1.6749818106226	CXCL2/FOXO3/TCF7L2/PRKAG2/C1QB/ACOX1/MAP2K3/LY96/NFKBIA/CXCL3/FASN/C1QA/C5AR1/FOXO1/PRKAB2/ACADVL/C1QC/IL1B/NFKB1/MAP3K5/MAP3K7/C3AR1/SREBF1/LPIN2/FADD/TCF7/MAP2K7/RIPK1/IRAK4/IKBKG/ALDH9A1/TAB2/MLYCD/TCF7L1/PRKAA1/TRAF3/TLR4/CAMKK2/IKBKB/MAP2K4/IKBKE/CHUK/C2/PPARA/LPIN1/SIRT1/PRKAB1/NOX4/CPT1A/TRAF6/TNF/IL17RC/TAB3/MAPK8/CPT1B	4.43614381468943
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	43/2138	105/9376	1.79592854915586	GADD45A/CXCL2/BCL2A1/LY96/NFKBIA/CXCL3/TNFSF13B/SYK/BLNK/XIAP/IL1B/TNFAIP3/ICAM1/NFKB1/MAP3K7/EDARADD/ATM/CSNK2A2/CD40/CFLAR/PPP1R13L/RIPK1/PLAU/IRAK4/IKBKG/CYLD/NFKB2/TAB2/BIRC2/TRIM25/TRAF3/TLR4/BIRC3/PTGS2/IKBKB/EDA2R/CHUK/BTK/TRAF6/TNF/TAB3/LAT/PLCG1	4.45744138486852
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	32/2138	71/9376	1.97652142979486	CXCL2/NFKBIA/CXCL3/ATP6V0D1/ATP6V1G1/ADAM17/TJP1/JAM2/ATP6V1E1/ADAM10/ATP6V1A/ATP6V1H/NFKB1/ATP6V1D/CSK/ATP6V1C1/HBEGF/ATP6AP1/ATP6V0E1/IKBKG/GIT1/CCL5/IKBKB/MAP2K4/CHUK/EGFR/ATP6V0A1/MET/CXCR2/MAPK8/PLCG1/NOD1	4.4888279845505
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	43/2138	106/9376	1.77898582699402	CDKN1A/CREB5/TCF7L2/NFKBIA/EP300/FOXO1/MMP9/CCNE1/MDM2/MAPK3/PIK3R1/PDPK1/CREBBP/SOS1/RAF1/ERBB2/NFKB1/CREB3L4/IGF1R/CREB3L2/CDKN1B/MAP2K1/RB1/TCF7/MAPK1/E2F2/PLAU/IKBKG/PIK3CA/CREB1/MTOR/TCF7L1/CCNE2/KRAS/ARAF/IKBKB/FOLR1/CHUK/EGFR/PDGFA/PIK3R2/PDGFB/PIK3R3	4.38351826939958
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	65/2138	180/9376	1.58361916640682	HLA-DRA/HLA-B/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/TAPBPL/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-A/HLA-DMB/NFKBIA/TAPBP/HLA-DQA2/SYK/TSC1/HLA-DRB5/PIK3R1/TNFRSF14/IL1B/BAX/SRSF2/NFKB1/IFNGR1/JAK1/HLA-F/MAP3K7/SRSF1/FADD/IFNAR1/EIF2B1/PPP1CC/IRAK4/IKBKG/PIK3CA/TAB2/BIRC2/HCFC1/RHEB/POU2F1/MTOR/OAS2/TRAF3/BIRC3/CCL5/RNASEL/IKBKB/TYK2/IKBKE/POU2F2/CHUK/TLR3/ITGA5/PIK3R2/BID/MAVS/HCFC2/TRAF6/IFIH1/TNF/PILRB/PIK3R3/CARD9/JAK2	4.29681362455434
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	67/2138	187/9376	1.57124205239541	CTSB/CXCL2/GABARAP/ITPR2/NFKBIA/CXCL3/GBP2/GABARAPL2/GBP3/NEK7/MAPK3/XIAP/IL1B/PKN2/IL18/IFI16/GPSM3/ANTXR2/TNFAIP3/CYBB/NFKB1/ITPR3/JAK1/MAP3K7/TRPM7/GBP1/FADD/IFNAR1/NAMPT/GABARAPL1/MAPK1/RIPK1/TXNIP/PYCARD/MCU/IRAK4/IKBKG/TAB2/BIRC2/OAS2/MFN2/CASP1/TRAF3/TLR4/BIRC3/CCL5/RNASEL/IKBKB/TYK2/IKBKE/CHUK/MAP1LC3B/MAVS/P2RX7/ATG16L1/PLCB1/TRAF6/TNF/TAB3/PSTPIP1/MAPK8/NLRP7/NAIP/NLRP3/CARD9/NOD1/CARD6	4.28831863824781
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	58/2138	157/9376	1.62008663373711	LRP1/RXRA/C1QB/DUSP2/CD36/TMEM30A/C1QA/DUSP4/CAMK2G/RAB5B/ANO6/LIPA/ADAM17/ABCA1/MAPK3/C1QC/ADAM10/PTK2/RAB14/HAVCR2/HIF1A/TMEM30B/PPARD/CRK/RAB5A/NFATC3/MAP2K1/SGK1/PTGER4/MAPK1/ATP2A2/PTPN6/CEBPB/CRKL/VPS8/CASP7/ALOX5/CREB1/ITGAV/ATP11C/DUSP7/SIRPA/CASP1/PTGS2/PLA2G15/DUSP8/CAMK2D/TGFB1/SIRT1/VPS11/CPT1A/TGFBRAP1/GULP1/PLA2G6/CPT1B/SPHK2/NFATC1/JAK2	4.25834150990591
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	31/2138	70/9376	1.94210877990111	CDKN1A/EPAS1/TGFB2/EP300/MAPK3/PIK3R1/CREBBP/SOS1/RAF1/HIF1A/RAPGEF1/CRK/PAK2/MAP2K1/MAPK1/CRKL/GAB1/PIK3CA/VHL/KRAS/ARAF/RAP1B/PIK3R2/MET/TGFB1/RBX1/PDGFB/ARNT2/PIK3R3/TFE3/VEGFA	4.29980486097677
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	45/2138	115/9376	1.71602879570505	CDKN1A/CREB5/RXRA/WNK1/GNAQ/AKAP13/ITPR2/GATA3/NR4A2/MAFB/SP1/MAPK3/ATF6B/WNK2/GNA11/RAF1/CREB3L4/ITPR3/CREB3L2/RXRB/GNA13/MAP2K1/SGK1/HBEGF/MAPK1/PLD1/CREB1/ATF2/ARAF/ADCY7/ARRB2/PDE4B/EGFR/PDE4C/PDE4A/PLCB1/JUND/ADCY6/MEF2A/ADCY9/EGR1/ARHGEF11/FOS/ARRB1/PRKACB	4.19885295224843
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	53/2138	142/9376	1.63680680904887	HERC1/ANAPC13/UBE2Q1/UBE2E2/UBE2A/MDM2/BRCA1/XIAP/ANAPC16/HUWE1/CDC23/UBE3A/DDB2/SIAH1/UBE2Z/ANAPC5/NEDD4/HERC2/BIRC6/FBXO4/MAP3K1/CUL1/SAE1/WWP2/CUL5/UBE2H/KLHL9/TRIM37/VHL/MID1/BIRC2/UBE2R2/UBE4A/FANCL/NEDD4L/DDB1/PPIL2/ANAPC7/BIRC7/BIRC3/UBA7/FBXW11/PIAS3/UBE2D4/RBX1/FBXW8/PIAS1/UBE2L6/TRAF6/UBE2O/DET1/FBXO2/CUL7	4.1556325064588
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	62/2138	173/9376	1.57164872361939	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DMB/NFKBIA/HNRNPUL1/EP300/HLA-DQA2/HLA-DRB5/MAPK3/PIK3R1/PABPN1/IL1B/CREBBP/IL18/BAX/RAF1/RAB11B/ICAM1/NFKB1/IFNGR1/JAK1/KPNA6/MAP2K1/FADD/IFNAR1/MAPK1/MX2/PYCARD/IRAK4/IKBKG/PIK3CA/CXCL10/TRIM25/OAS2/CASP1/TRAF3/TLR4/CCL5/RNASEL/IKBKB/TNFRSF10A/TYK2/IKBKE/CHUK/TLR3/TNFSF10/PIK3R2/BID/RSAD2/MAVS/TNFRSF10B/IFIH1/TNF/PIK3R3/NLRP3/JAK2/KPNA5	4.1244664756363
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	47/2138	122/9376	1.68946004385898	CREB5/FOXO3/PRKAG2/FBP1/CD36/FASN/FOXO1/IRS2/TSC1/PRKAB2/PIK3R1/CAB39/PDPK1/TBC1D1/RAB14/RAB11B/CREB3L4/IGF1R/CREB3L2/PPP2CA/MAP3K7/SREBF1/PPP2CB/RPS6KB1/PPP2R5E/PFKFB4/PIK3CA/CREB1/MLYCD/RHEB/MTOR/PCK2/STK11/PRKAA1/STRADB/CAMKK2/CRTC2/PIK3R2/SIRT1/PRKAB1/CPT1A/LEPR/RPTOR/ULK1/PIK3R3/CPT1B/PFKFB2	4.1658580712691
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	47/2138	122/9376	1.68946004385898	MED13L/RXRA/RCAN1/EP300/NOTCH2/FOXO1/NCOA1/THRB/MDM2/MAPK3/PIK3R1/MED13/PDPK1/PLCD3/CREBBP/NCOA2/ATP1B1/RAF1/MED1/HIF1A/RXRB/MED4/MED17/MAP2K1/MAPK1/ATP2A2/NCOR1/PIK3CA/SLC9A1/ITGAV/RHEB/MTOR/SIN3A/KRAS/SLC16A10/TBC1D4/MED12/MED14/PIK3R2/PLCE1/NOTCH1/DIO2/PLCB1/PIK3R3/PLCG1/PRKACB/PFKFB2	4.1658580712691
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	61/2138	170/9376	1.57358718978705	CDKN2A/CDKN1A/IGF2/GADD45A/GSTT1/TCF7L2/HMOX1/BRD7/WNT7A/TGFB2/TGFBR1/ARID1A/AXIN2/FZD1/SMARCE1/SMAD4/MAPK3/PIK3R1/SMARCD2/PBRM1/SOS1/BAX/RAF1/IGF1R/DDB2/SMAD2/MAP2K1/FZD6/RB1/FRAT2/RPS6KB1/TCF7/MAPK1/E2F2/NFE2L2/GAB1/PIK3CA/TXNRD3/MTOR/SMARCD1/TCF7L1/KRAS/ARID2/ARAF/APC/PHF10/FZD7/WNT6/EGFR/PIK3R2/MET/TGFB1/WNT5B/GSTM4/FZD3/SMAD3/FZD8/PIK3R3/WNT11/FRAT1/PLCG1	4.10174462925528
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	46/2138	120/9376	1.68107265357032	ARHGDIB/FOXO3/NFKBIA/CAMK2G/MAPK3/PIK3R1/PDPK1/SOS1/BAX/RAF1/NFKB1/RPS6KA3/MAP3K5/PSEN1/RAPGEF1/CRK/MAP2K1/KIDINS220/MAP3K1/MAPK1/RPS6KA5/MAP2K7/FRS2/CRKL/GAB1/IRAK4/PIK3CA/MAP3K3/MATK/KRAS/NFKBIE/RAP1B/SH2B3/IKBKB/MAGED1/PIK3R2/SH2B1/CAMK2D/PRDM4/TRAF6/MAPK7/MAPK8/PIK3R3/IRAK3/PLCG1/PSEN2	4.08086842150315
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	38/2138	94/9376	1.77282407499552	CXCL2/NFKBIA/CXCL3/IL17RE/MMP9/MAPK3/MAPK6/IL1B/TNFAIP3/NFKB1/CCL20/MAP3K7/S100A8/SRSF1/FADD/ANAPC5/MAPK1/TRAF3IP2/CEBPB/IKBKG/TAB2/CXCL10/TRAF3/PTGS2/IKBKB/IKBKE/CHUK/CCL7/JUND/TRAF6/S100A9/MAPK7/TNF/IL17RC/TAB3/MAPK8/FOS/FOSL1	4.09264416697694
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	57/2138	158/9376	1.58207718085043	WNT7A/SLC38A9/FZD1/TSC1/ATP6V1G1/MAPK3/PIK3R1/ATP6V1E1/RRAGC/CAB39/PDPK1/LAMTOR3/ATP6V1A/SOS1/ATP6V1H/RAF1/RPS6KA3/IGF1R/LPIN2/MAP2K1/SGK1/FZD6/ATP6V1D/ATP6V1C1/TELO2/RPS6KB1/MAPK1/MLST8/PIK3CA/RHEB/RRAGD/RICTOR/MTOR/FNIP1/KRAS/STK11/FZD7/PRKAA1/STRADB/FNIP2/IKBKB/WNT6/SESN2/CHUK/PIK3R2/LPIN1/WNT5B/ULK2/FZD3/DEPTOR/TNF/RPTOR/ULK1/WDR24/FZD8/PIK3R3/WNT11	4.01024554305246
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	32/2138	75/9376	1.87110695353913	CDKN2A/SERPINE1/CDKN1A/IGFBP3/GADD45A/CCNG2/SESN1/CCNE1/MDM2/CCNG1/BAX/PMAIP1/CDK1/DDB2/MDM4/ATM/SIAH1/GTSE1/PPP1R13L/BBC3/RRM2B/CCNE2/ATR/PPM1D/GORAB/SESN2/TNFRSF10A/BID/ZMAT3/CD82/TNFRSF10B/AIFM2	4.11639923891415
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	113/2138	362/9376	1.36892536526624	SPP1/CSH2/CDKN1A/IGF2/CSH1/FN1/CREB5/ITGA6/CSF3R/COL4A1/FOXO3/LAMC1/RXRA/ERBB3/COL4A2/YWHAG/LAMA5/ITGB4/SYK/EFNA1/BCL2L11/TSC1/RBL2/CSF1R/CCNE1/MDM2/MAPK3/PIK3R1/BRCA1/ATF6B/EREG/ITGB6/GNG12/PDPK1/PTK2/PKN2/OSM/SOS1/YWHAZ/RAF1/ERBB2/LAMC2/NFKB1/CREB3L4/IGF1R/CREB3L2/JAK1/GNG4/PPP2CA/OSMR/CDKN1B/MAP2K1/SGK1/CSHL1/PPP2CB/IFNAR1/RPS6KB1/PPP2R5E/MAPK1/GH2/MLST8/ITGB1/PIK3AP1/IKBKG/PIK3CA/CREB1/ITGAV/RHEB/ATF2/FGFR3/MTOR/CCNE2/PCK2/KRAS/IL2RG/EFNA5/STK11/COL9A3/ITGA3/LAMB4/PRKAA1/ITGA2/TLR4/IKBKB/IL2RB/CHUK/EGFR/CRTC2/ITGA5/CDC37/PDGFA/PIK3R2/MET/PIK3R5/SGK3/PDGFB/IL6R/GNG10/LAMB3/RPTOR/MCL1/PIK3R3/IL4R/ANGPT2/IL7R/GNGT1/ITGA2B/EFNA2/JAK3/JAK2/VWF/NRTN/VEGFA	3.8905788682849
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	39/2138	99/9376	1.72758454517107	CDKN2A/CDKN1A/NOTCH2/MMP9/MDM2/SP1/MAPK3/PIK3R1/PTK2/SOS1/BAX/RAF1/MED1/ERBB2/IGF1R/CDKN1B/MAP2K1/RB1/HBEGF/RPS6KB1/MAPK1/E2F2/JAG2/NCOR1/PIK3CA/MTOR/KRAS/ARAF/ADCY7/EGFR/PIK3R2/NOTCH1/ADCY6/ADCY9/MAPK8/PIK3R3/DLL1/FOS/PRKACB	3.95528228149166
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	39/2138	99/9376	1.72758454517107	TSC1/GPCPD1/DGKH/CHKB/SP1/MAPK3/PIK3R1/PDPK1/LYPLA1/RALGDS/SOS1/RAF1/HIF1A/CHPT1/MAP2K1/RPS6KB1/MAPK1/PLD1/PIK3CA/WAS/RHEB/PIP5K1A/MTOR/KRAS/RAC2/SLC44A2/WASF2/EGFR/PDGFA/PIK3R2/PDGFB/WASF1/SLC44A5/MAPK8/SLC22A4/DGKA/PIK3R3/PLCG1/FOS	3.95528228149166
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	42/2138	109/9376	1.68978982329366	PTPRF/CREB5/PRKAG2/CD36/NFKBIA/FOXO1/IRS2/PRKAB2/PPP1R3D/PIK3R1/PDPK1/NFKB1/CREB3L4/RPS6KA3/CREB3L2/SREBF1/MLXIP/RPS6KB1/PTPN1/PPP1CC/PIK3CA/CREB1/PRKCE/MTOR/PCK2/TBC1D4/PRKAA1/IKBKB/OGT/SLC27A1/CRTC2/PIK3R2/PPARA/PRKAB1/CPT1A/PPARGC1B/TNF/PYGB/MAPK8/PPP1R3E/PIK3R3/CPT1B	3.93677550210712
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	40/2138	103/9376	1.70307064945916	SERPINE1/C1QB/GNAQ/NFKBIA/TGFB2/TGFBR1/C1QA/CCL3/MAPK3/PIK3R1/NOS2/C1QC/IL1B/GNA11/NFKB1/IFNGR1/PPP2CA/SMAD2/PPP2CB/FADD/MAPK1/CFLAR/IRAK4/IKBKG/PIK3CA/TLR4/CCL5/IKBKB/MAP2K4/CHUK/PIK3R2/GNA15/TGFB1/PLCB1/TRAF6/TNF/MAPK8/GNAL/PIK3R3/FOS	3.89930897968605
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	20/2138	41/9376	2.1392228889548	RPA1/BARD1/BRCA1/RPA2/BRCA2/POLD4/XRCC2/ATM/MUS81/RAD51/TOPBP1/BLM/RBBP8/POLD1/TOP3A/PALB2/RAD54B/BRIP1/EME1/RPA4	3.97304668813255
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	20/2138	41/9376	2.1392228889548	CDKN2A/CDKN1A/DAPK1/MMP9/MDM2/MAPK3/RAF1/ERBB2/MAP2K1/RB1/HBEGF/RASSF1/MAPK1/E2F2/RPS6KA5/FGFR3/KRAS/ARAF/EGFR/VEGFA	3.97304668813255
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	32/2138	78/9376	1.79914130147994	IP6K2/PLCD3/PI4KA/PIP4K2C/IPMK/PIK3CA/SYNJ2/PIP5K1A/OCRL/PIKFYVE/PIP4K2A/INPPL1/PI4K2A/PI4K2B/PLCE1/PLCH1/INPP4A/PIK3C3/MTMR1/FIG4/ITPKC/MTMR6/PLCB1/PIP4K2B/ITPK1/ITPKA/MTMR3/MTM1/PIP5KL1/INPP1/PLCG1/PPIP5K1	3.8517341691395
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	39/2138	101/9376	1.69337495021719	SERPINE1/FN1/PIM1/COL4A1/COL4A2/TGFB2/TGFBR1/FOXO1/SMAD4/MAPK3/PIK3R1/IL1B/PLCD3/BAX/ICAM1/CYBB/NFKB1/CDKN1B/SMAD2/MAPK1/PIK3CA/PRKCE/KRAS/PIK3R2/PLCE1/THBD/TGFB1/NOX4/PLCB1/TNF/SMAD3/MAPK8/EGR1/PIK3R3/STAT5A/PLCG1/NFATC1/JAK2/VEGFA	3.8076066329714
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	82/2138	253/9376	1.42135718432135	FOXO3/ITPR2/NFKBIA/TLN2/FOXO1/CD44/MDM2/MAPK3/PIK3R1/RRAGC/ARHGEF2/HCLS1/IL1B/PLCD3/PTK2/IL18/BAX/CBX3/NFKB1/ARPC2/ITPR3/MAP3K7/CAPN2/CRK/ARF6/ATM/RPS6KB1/MAPK1/CUL1/RPS6KA5/VCL/RIPK1/CYTH2/CRKL/TNIP1/ITGB1/PYCARD/FNBP1L/TECPR1/IKBKG/PIK3CA/TAB2/PRKCE/RRAGD/MTOR/WASL/TIFA/CYTH3/CASP1/TLR4/SQSTM1/CCL5/IKBKB/WASF2/ATG14/CHUK/U2AF1L4/EGFR/ITGA5/FBXW11/UBE2D4/CYTH1/PIK3R2/PLCE1/MAP1LC3B/PIK3C3/RBX1/ATG16L1/PLCB1/TRAF6/TNF/WASF1/TAB3/RPTOR/MAPK8/CYTH4/NAIP/ELMO2/PIK3R3/NLRP3/PLCG1/NOD1	3.69251293754416
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	16/2138	30/9376	2.33888369192392	PIGT/PIGP/DPM2/PGAP3/GPAA1/PIGF/PIGM/MPPE1/PIGU/PIGC/B3GALT4/PIGO/PIGN/PIGQ/PIGV/PIGA	3.99181853157294
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	76/2138	232/9376	1.43659881939292	FN1/ITGB2/ITGA6/CXCR4/DIAPH2/RGCC/CYFIP2/VAV3/TIAM1/LIMK2/ITGB4/SSH2/ITGAX/MAPK3/PIK3R1/ITGB6/GNG12/PTK2/SCIN/SOS1/RAF1/ARPC2/GNA13/CRK/PAK2/CHRM5/MAP2K1/ITGAM/ARHGEF7/PIP4K2C/RRAS2/MAPK1/VCL/VAV2/CRKL/ITGB1/PPP1CC/MSN/SSH3/SPATA13/PIK3CA/NCKAP1L/SLC9A1/ITGAV/PIP5K1A/FGFR3/BAIAP2/ARHGEF12/WASL/PPP1R12B/KRAS/PIKFYVE/RAC2/ARAF/ITGA3/APC/PIP4K2A/ITGA2/TMSB4Y/GIT1/ITGAL/WASF2/EGFR/ITGA5/PDGFA/PIK3R2/MRAS/SSH1/FGD3/PDGFB/PIP4K2B/IQGAP3/WASF1/PIK3R3/VAV1/ITGA2B	3.65964231056151
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	45/2138	122/9376	1.61756812709902	CSH2/CSH1/IGFBP3/CREB5/MAP2K3/GNAQ/ITPR2/EP300/IRS2/MAPK3/PIK3R1/ATF6B/CREBBP/PTK2/SOS1/GNA11/RAF1/CREB3L4/ITPR3/CREB3L2/CRK/MAP2K1/CSHL1/MAP3K1/MAPK1/GH2/CRKL/PIK3CA/CREB1/ATF2/MTOR/KRAS/ADCY7/MAP2K4/PIK3R2/PLCB1/ADCY6/ADCY9/MAPK8/PIK3R3/STAT5A/PLCG1/FOS/JAK2/PRKACB	3.73147246131093
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	71/2138	214/9376	1.45497145554846	HLA-B/TAPBPL/HLA-A/CXCR4/MAP2K3/GNAQ/ITPR2/NFKBIA/APOBEC3B/TAPBP/LIMK2/MAPK3/PIK3R1/GNG12/CD4/PTK2/BAX/GNA11/RAF1/PPP3R1/NFKB1/ITPR3/GNG4/CDK1/HLA-F/MAP3K7/AP1S2/PPP3CA/CRK/PAK2/NFATC3/MAP2K1/SAMHD1/ATM/FADD/RPS6KB1/MAPK1/CUL1/MAP2K7/CUL5/RIPK1/PPP3CB/CRKL/IRAK4/IKBKG/PIK3CA/TAB2/MTOR/DDB1/KRAS/RAC2/ATR/TLR4/IKBKB/CHUK/FBXW11/TNFRSF1B/PIK3R2/BID/RBX1/APOBEC3A/GNG10/TRAF6/TNF/APOBEC3G/MAPK8/PIK3R3/PLCG1/GNGT1/FOS/NFATC1	3.65911528352524
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	30/2138	73/9376	1.80222202288658	CDKN2A/CDKN1A/GADD45A/FOXO3/RXRA/MAPK3/PIK3R1/PDPK1/SOS1/BAX/RAF1/ERBB2/RXRB/DDB2/MAP2K1/RB1/RASSF1/MAPK1/E2F2/PIK3CA/KRAS/ARAF/EGFR/PIK3R2/MET/RASSF5/PIK3R3/STAT5A/PLCG1/JAK3	3.73959610742995
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	67/2138	201/9376	1.46180230745245	HPGD/CDKN1A/ASPSCR1/IGFBP3/GADD45A/RXRA/SPI1/BCL2A1/REL/FUT8/BMI1/FOXO1/CEBPA/BCL6/CSF1R/JUP/MMP9/MDM2/SP1/PTK2/FCGR1A/BAX/NFKB1/IGF1R/RXRB/CCNT1/SMAD1/CD86/DDB2/CDKN1B/ATM/ITGAM/SUPT3H/RUNX1/CD40/SIX4/ETV6/NCOR1/CEBPB/DOT1L/PER2/CCNT2/CDK9/JMJD1C/PLAU/NR4A3/BIRC2/ELK4/SIN3A/KLF3/BIRC3/PBX3/IL2RB/NUPR1/PDGFA/MET/SS18L1/LDB1/LYL1/FUS/ARNT2/RARA/TFE3/ETV7/NFKBIZ/ELANE/MITF	3.59692423567355
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	54/2138	155/9376	1.52781918585353	CDKN2A/CDKN1A/CREB5/TCF7L2/GNAQ/ITPR2/WNT7A/AXIN2/CAMK2G/FZD1/CCNE1/SP1/MAPK3/ATF6B/AHR/GNA11/CREB3L4/ITPR3/CREB3L2/CDKN1B/MAP2K1/FZD6/CRH/RB1/TCF7/MAPK1/E2F2/USP8/CREB1/NCEH1/ATF2/TCF7L1/CCNE2/SCARB1/APC/FZD7/ADCY7/RAP1B/WNT6/EGFR/PDE8A/CDKN2B/CAMK2D/KMT2D/WNT5B/PLCB1/ADCY6/FZD3/ARMC5/ADCY9/FZD8/WNT11/PRKACB/CACNA1G	3.60115827719663
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	66/2138	200/9376	1.44718428437792	CLDN19/CYFIP2/NFKBIA/CLDN23/MAPK3/TJP1/ARHGEF2/HCLS1/IL1B/IL18/WIPF2/BAX/NFKB1/ARPC2/MAP3K7/GNA13/RAB1A/PAK2/MYO1F/FCGR2A/ARF6/FADD/MAPK1/MYO1D/PTPN6/MYO5C/RIPK1/SEC24D/ABI1/CYTH2/ITGB1/PYCARD/IRAK4/IKBKG/CASP7/SEC24C/TAB2/NCKAP1L/BAIAP2/ARHGEF12/WASL/CYTH3/CASP1/WIPF1/TLR4/CLDN14/IKBKB/TNFRSF10A/WASF2/CHUK/TNFSF10/CYTH1/MYO5B/TNFRSF10B/MYO5A/TRAF6/TNF/WASF1/TAB3/MAPK8/CYTH4/NAIP/TUBA4A/NLRP3/ARHGEF11/FOS	3.47420168952931
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	37/2138	98/9376	1.65571485844104	ITPR2/DGKH/IP6K2/PIK3R1/PLCD3/ITPR3/CDS1/PI4KA/PIP4K2C/IPMK/PIK3CA/SYNJ2/PIP5K1A/OCRL/PIKFYVE/PIP4K2A/INPPL1/PI4K2A/PI4K2B/PIK3R2/PLCE1/INPP4A/PIK3C3/MTMR1/ITPKC/MTMR6/PLCB1/PIP4K2B/ITPK1/ITPKA/MTMR3/DGKA/MTM1/PIK3R3/INPP1/PLCG1/PPIP5K1	3.54634577538028
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	64/2138	193/9376	1.45422820223249	CCR1/CXCR6/CXCR4/CXCL2/FOXO3/CXCL16/GNAQ/VAV3/TIAM1/NFKBIA/CXCL3/CCL3/MAPK3/PIK3R1/GNG12/PTK2/CCL18/GRK4/SOS1/RAF1/NFKB1/GNG4/CCL20/CXCL9/CRK/MAP2K1/FGR/MAPK1/VAV2/CRKL/IKBKG/PIK3CA/DOCK2/CXCL10/HCK/WAS/KRAS/PREX1/RAC2/ADCY7/ARRB2/CCL5/RAP1B/IKBKB/CHUK/PIK3R2/CCL7/PIK3R5/PLCB1/ADCY6/GNG10/XCL1/CXCR2/ADCY9/PIK3R3/CCL28/VAV1/PLCG1/GNGT1/ARRB1/JAK3/JAK2/PRKACB/XCR1	3.46529855038972
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	52/2138	150/9376	1.52027439975055	CDKN1A/GADD45A/TCF7L2/RXRA/WNT7A/TGFB2/TGFBR1/AXIN2/FZD1/JUP/SMAD4/CCNE1/MAPK3/PIK3R1/SOS1/BAX/RAF1/ERBB2/RXRB/DDB2/CDKN1B/SMAD2/MAP2K1/FZD6/RB1/FRAT2/RPS6KB1/TCF7/MAPK1/E2F2/GAB1/PIK3CA/MTOR/TCF7L1/CCNE2/KRAS/ARAF/APC/FZD7/WNT6/EGFR/PIK3R2/MET/CDKN2B/TGFB1/WNT5B/FZD3/SMAD3/FZD8/PIK3R3/WNT11/FRAT1	3.49101375895614
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	26/2138	62/9376	1.83904161260147	FOXO3/PRKAG2/FOXO1/IRS2/EIF4EBP2/PRKAB2/PIK3R1/IGF1R/CAT/RPS6KB1/HSPA6/PIK3CA/SOD1/MTOR/KRAS/PRKAA1/ADCY7/PIK3R2/SIRT1/PRKAB1/ADCY6/RPTOR/ADCY9/PIK3R3/HSPA1B/PRKACB	3.60239579963139
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	40/2138	109/9376	1.60932364123205	SPP1/MAP2K3/LY96/NFKBIA/CCL3/MAPK3/PIK3R1/IL1B/NFKB1/JAK1/MAP3K7/CD86/CXCL9/MAP2K1/FADD/IFNAR1/CD40/MAPK1/MAP2K7/RIPK1/IRAK4/IKBKG/PIK3CA/TAB2/CXCL10/TRAF3/TLR4/CCL5/IKBKB/MAP2K4/TYK2/IKBKE/CHUK/TLR3/PIK3R2/TRAF6/TNF/MAPK8/PIK3R3/FOS	3.47753808863581
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	28/2138	69/9376	1.7795854177682	FCER1G/MAP2K3/VAV3/ALOX5AP/SYK/MAPK3/PIK3R1/PDPK1/SOS1/RAF1/LCP2/MAP2K1/MAPK1/MAP2K7/VAV2/PIK3CA/ALOX5/KRAS/RAC2/MAP2K4/BTK/PIK3R2/TNF/MAPK8/PIK3R3/VAV1/LAT/PLCG1	3.5323489093551
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	33/2138	86/9376	1.68277242369526	CDKN1A/ERBB3/CAMK2G/MAPK3/PIK3R1/EREG/PTK2/SOS1/RAF1/ERBB2/CDKN1B/CRK/PAK2/MAP2K1/HBEGF/RPS6KB1/MAPK1/MAP2K7/CRKL/GAB1/PIK3CA/ABL2/MTOR/KRAS/ARAF/MAP2K4/EGFR/PIK3R2/CAMK2D/MAPK8/PIK3R3/STAT5A/PLCG1	3.45698535779103
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	48/2138	138/9376	1.5253589295156	PTPRF/PRKAG2/FBP1/FASN/FOXO1/IRS2/PHKA2/TSC1/PRKAB2/PPP1R3D/MAPK3/PIK3R1/PDPK1/PRKAR1A/SOS1/RAF1/RAPGEF1/SREBF1/CRK/MAP2K1/TRIP10/PHKB/FLOT2/RPS6KB1/MAPK1/PTPN1/CRKL/PPP1CC/PIK3CA/RHEB/MTOR/PCK2/KRAS/ARAF/PDE3B/INPPL1/PRKAA1/IKBKB/PIK3R2/PRKAB1/PRKAR2B/PYGB/RPTOR/MAPK8/PRKAR1B/PPP1R3E/PIK3R3/PRKACB	3.37898980820445
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	28/2138	70/9376	1.75416276894294	PRKAG2/RXRA/CD36/NFKBIA/IRS2/PRKAB2/NFKB1/RXRB/ACSL5/IKBKG/MTOR/PCK2/STK11/NFKBIE/PRKAA1/CAMKK2/IKBKB/CHUK/ACSL1/TNFRSF1B/PPARA/PRKAB1/CPT1A/LEPR/TNF/MAPK8/CPT1B/JAK2	3.44201519935832
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	78/2138	248/9376	1.3792812094511	TCF7L2/CYFIP2/MAP2K3/LY96/NFKBIA/DYNLT1/PTPRC/RAB5B/AHNAK/MAPK3/DCTN4/DYNC1I2/IL1B/IL18/BAX/RAF1/NFKB1/ARPC2/DCTN1/MAP3K7/RAB5A/MAP2K1/PLEKHM2/ARF6/FADD/DYNC1LI2/DNM2/TCF7/MAPK1/DYNLL2/MAP2K7/RIPK1/ABI1/CYTH2/PYCARD/IRAK4/IKBKG/PIK3CA/CASP7/TAB2/BIRC2/NCKAP1L/EXOC2/TCF7L1/WASL/CYTH3/RHOB/CASP1/TLR4/BIRC3/IKBKB/MAP2K4/TNFRSF10A/CHUK/TNFSF10/CYTH1/PIK3C3/TNFRSF10B/RILP/VPS11/RAB9B/FHOD1/TRAF6/PLEKHM1/TNF/TAB3/MAPK8/CYTH4/KLC4/NAIP/TUBA4A/ELMO2/MLKL/NLRP3/DYNLRB2/NOD1/FOS/SNX33	3.28987616705579
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	31/2138	80/9376	1.69934518241347	FOXO3/ERBB3/BCL2L11/MAPK3/PIK3R1/SOS1/BAX/RAF1/ERBB2/IGF1R/JAK1/MAP2K1/RPS6KB1/MAPK1/GAB1/PIK3CA/NF1/FGFR3/MTOR/KRAS/ARAF/EGFR/PDGFA/PIK3R2/MET/PDGFB/IL6R/PIK3R3/PLCG1/JAK2/VEGFA	3.4140409242906
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	29/2138	75/9376	1.69569067664484	CDKN2A/CDKN1A/GSTT1/TOP2A/MDM2/MAPK3/PIK3R1/BRCA1/XIAP/PDPK1/BAX/ERBB2/MAP3K5/PMAIP1/ATM/FADD/TOP2B/MAPK1/BBC3/PIK3CA/BIRC2/MSH2/BIRC3/PIK3R2/BID/ATP7A/GSTM4/POLH/PIK3R3	3.28747297932325
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	24/2138	59/9376	1.7838943412979	CDKN1A/GADD45A/FOXO3/TCF7L2/AXIN2/MAPK3/PIK3R1/PDPK1/SOS1/BAX/RAF1/ERBB2/DDB2/MAP2K1/TCF7/MAPK1/PIK3CA/TCF7L1/KRAS/ARAF/APC/EGFR/PIK3R2/PIK3R3	3.28265836381863
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	37/2138	103/9376	1.57534035074973	FN1/ITGB2/PRDX1/COL4A1/CXCL2/LAMC1/COL4A2/SERPINB9/GNAQ/TGFB2/CXCL3/LAMA5/RAB5B/PIK3R1/SERPINB6/NOS2/IL1B/PTK2/GNA11/LAMC2/NFKB1/RAB5A/ITGAM/VCL/PIK3CA/LAMB4/TLR4/PIK3R2/GNA15/TGFB1/PLCB1/LAMB3/TNF/GNAL/PIK3R3/HSPB1/PRKACB	3.19090236205975
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	39/2138	110/9376	1.55482609065397	FBN1/SKIL/FST/HAMP/TGFB2/TGFBR1/EP300/BMPR2/SMAD4/SP1/MAPK3/CREBBP/BAMBI/SMAD1/PPP2CA/SMAD2/TFRC/PPP2CB/ACVR2B/RPS6KB1/MAPK1/CUL1/RBL1/NCOR1/NOG/SIN3A/LEMD3/RGMB/SMAD5/ACVR1/SKI/TMEM53/SMAD7/CDKN2B/TGFB1/RBX1/TNF/SMAD3/ACVR2A	3.18117286589175
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	23/2138	56/9376	1.80114927168248	EEF1A1/ITGB2/CXCL2/NFKBIA/CXCL3/RAB1B/IL1B/IL18/NFKB1/RAB1A/ITGAM/CLK1/CLK4/HSPA6/PYCARD/CASP7/NFKB2/CASP1/TLR4/TNF/EEF1A2/NAIP/HSPA1B	3.26798232363585
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	26/2138	66/9376	1.72758454517107	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DMB/TGFB2/GATA3/HLA-DQA2/HLA-DRB5/IL1B/IL18/STAT6/NFKB1/IFNGR1/SMAD2/IL2RG/TLR4/STAT4/TGFB1/TNF/SMAD3/IL4R/NFATC1	3.22374582014983
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	34/2138	93/9376	1.60326704688333	PTPRF/TCF7L2/TGFBR1/EP300/SMAD4/MAPK3/TJP1/CREBBP/ERBB2/IGF1R/KRIT1/MAP3K7/CSNK2A2/TCF7/MAPK1/PTPN1/PTPN6/VCL/SNAI1/WAS/BAIAP2/TCF7L1/WASL/RAC2/CDH5/LMO7/RAP1B/WASF2/EGFR/MET/NLK/WASF1/SMAD3/PTPRM	3.17751128165352
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	31/2138	83/9376	1.63792306738648	PRDX1/ACOX1/FAR2/NUDT19/ABCD1/AGXT/CRAT/PXMP2/NOS2/IDH1/SCP2/PIPOX/PEX11B/ACSL5/FAR1/CAT/PEX19/GSTK1/SOD1/PEX7/MLYCD/EPHX2/NUDT7/DECR2/DHRS4/PEX26/ACSL1/PEX3/GNPAT/PEX12/AMACR	3.1725580944676
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	12/2138	23/9376	2.2880383942734	RPA1/PCNA/RFC3/RFC1/RFC2/RPA2/LIG1/POLD4/EXO1/MSH2/POLD1/RPA4	3.36122402352904
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	19/2138	44/9376	1.89369844374522	PCNA/RFC3/PARP4/RFC1/RFC2/LIG1/POLE3/POLD4/PARP2/TDG/POLE/MBD4/UNG/FEN1/POLG/POLD1/POLE2/NEIL3/PARG	3.22931324693577
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	27/2138	70/9376	1.69151409862355	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/ITGB2/HLA-A/HLA-DMB/DAG1/HLA-DQA2/HLA-DRB5/SGCE/ICAM1/HLA-F/CD86/CD40/EIF4G1/ABL2/EIF4G3/RAC2/ITGAL/SNTB1/SNTB2/BID	3.15608531215217
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	48/2138	144/9376	1.46180230745245	KLF4/SKIL/IL6ST/WNT7A/BMPR2/JARID2/ISL1/BMI1/ZFHX3/KAT6A/AXIN2/FZD1/SMAD4/MAPK3/PIK3R1/RAF1/IGF1R/JAK1/SMAD1/RIF1/SMAD2/MAP2K1/FZD6/ACVR2B/TCF7/MAPK1/PIK3CA/FGFR3/KRAS/APC/SMARCAD1/FZD7/WNT6/SMAD5/ACVR1/SETDB1/PIK3R2/WNT5B/FZD3/DUSP9/HOXA1/SMAD3/FZD8/PIK3R3/ACVR2A/WNT11/JAK3/JAK2	3.03507652735835
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	57/2138	178/9376	1.404315699856	TCF7L2/SFRP1/ANKRD6/WNT7A/EP300/TLE6/TLE4/TLE3/AXIN2/CAMK2G/FZD1/SMAD4/CREBBP/DAAM1/PPP3R1/BAMBI/PSEN1/MAP3K7/MMP7/PPARD/PPP3CA/TBL1XR1/RYK/NFATC3/FZD6/CSNK2A2/SIAH1/FRAT2/TCF7/CUL1/PPP3CB/CBY1/TCF7L1/RAC2/APC/FZD7/WNT6/VANGL1/FBXW11/CAMK2D/SIRT1/ROR1/RBX1/WNT5B/NLK/PLCB1/FZD3/NOTUM/SMAD3/MAPK8/FZD8/WNT11/FRAT1/ZNRF3/NFATC1/FOSL1/PRKACB	2.95981184178396
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	52/2138	160/9376	1.42525724976614	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/PTPRF/HLA-DQA1/HLA-DQB1/CLDN19/HLA-DMA/ITGB2/HLA-A/ITGA6/HLA-DMB/ESAM/NLGN4X/MAG/CD99/PTPRS/HLA-DQA2/PTPRC/CLDN23/HLA-DRB5/JAM2/CD4/ALCAM/GLG1/ICAM1/CD274/HLA-F/CD86/ITGAM/SDC4/CD40/CD22/ITGB1/ITGAV/PVR/CD99L2/CDH5/CLDN14/SIGLEC1/ITGAL/CD58/PDCD1LG2/SPN/SELPLG/SDC2/NLGN2/VTCN1/PTPRM/ICOSLG	2.94863274219943
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	47/2138	142/9376	1.4515079250056	GSTT1/HMOX1/BMPR2/NCF2/MMP9/PIK3R1/ARHGEF2/IL1B/PTK2/ICAM1/NFKB1/MAP3K5/MAP3K7/SDC4/ACVR2B/MAP2K7/NFE2L2/IKBKG/PIK3CA/ITGAV/CTSL/RAC2/CDH5/PRKAA1/SQSTM1/DUSP1/IKBKB/MAP2K4/ACVR1/CHUK/PDGFA/PIK3R2/THBD/SDC2/GSTM4/PDGFB/KLF2/MAPK7/TNF/MEF2A/MAPK8/PIK3R3/ACVR2A/ITGA2B/FOS/SUMO4/VEGFA	2.94642108629377
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	64/2138	205/9376	1.36910264893107	HLA-B/CDKN2A/CDKN1A/HLA-A/CREB5/YWHAG/IL6ST/REL/NFKBIA/EP300/ATP6V0D1/USP7/SYK/VAC14/CHD4/RBL2/CCNE1/MDM2/MAPK3/PIK3R1/ATF6B/CREBBP/RBPJ/SCIN/BAX/YWHAZ/NFKB1/CREB3L4/CREB3L2/JAK1/PMAIP1/CDK1/TBP/UBR4/HLA-F/UBE3A/CDKN1B/DLG1/EGR2/RB1/EGR3/MAPK1/RBL1/SRF/HDAC6/DNAJA3/IKBKG/PIK3CA/NFKB2/CREB1/ATF2/DDB1/CCNE2/KRAS/TRAF3/GTF2E1/RASA2/PIK3R2/CDKN2B/HDAC4/PIK3R3/STAT5A/JAK3/PRKACB	2.90399554014269
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	15/2138	33/9376	1.9933667828897	AGXT/AADAT/BCAT2/DHTKD1/IDH1/IDH3B/ACO1/GOT2/OGDH/DBT/CS/BCAT1/BCKDHB/GPT/BCKDHA	3.10673083798247
Human Diseases	Cancer: specific types	hsa05214	Glioma	28/2138	76/9376	1.61567623455271	CDKN2A/CDKN1A/GADD45A/CAMK2G/MDM2/MAPK3/PIK3R1/SOS1/BAX/RAF1/IGF1R/DDB2/MAP2K1/RB1/MAPK1/E2F2/PIK3CA/MTOR/KRAS/ARAF/EGFR/PDGFA/PIK3R2/CAMK2D/PDGFB/CAMK1D/PIK3R3/PLCG1	2.92885526703249
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	41/2138	122/9376	1.47378429357911	VAV3/NFKBIA/PTPRC/MAPK3/PIK3R1/PDPK1/CD4/SOS1/RAF1/PPP3R1/LCP2/NFKB1/PPP2CA/MAP3K7/DLG1/PPP3CA/PAK2/NFATC3/MAP2K1/PPP2CB/PPP2R5E/MAPK1/PTPN6/MAP2K7/VAV2/PPP3CB/IKBKG/PIK3CA/KRAS/NFKBIE/IKBKB/CHUK/PIK3R2/TNF/MAPK8/PIK3R3/VAV1/LAT/PLCG1/FOS/NFATC1	2.86270124139458
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	44/2138	133/9376	1.45081131265957	HLA-B/TYROBP/FCER1G/ITGB2/HLA-A/FCGR3A/VAV3/SYK/HCST/CD48/MAPK3/PIK3R1/SOS1/RAF1/PPP3R1/ICAM1/LCP2/IFNGR1/PPP3CA/MAP2K1/IFNAR1/MAPK1/PTPN6/VAV2/PPP3CB/PIK3CA/KRAS/RAC2/ARAF/LAT2/ITGAL/TNFRSF10A/TNFSF10/PIK3R2/SH3BP2/BID/TNFRSF10B/TNF/PIK3R3/VAV1/LAT/FCGR3B/PLCG1/NFATC1	2.84573430261507
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	27/2138	73/9376	1.62199982059792	CXCR4/APOBEC3B/EP300/VPS4B/ELL2/NUP153/SERINC3/CD4/CREBBP/PDCD6IP/MDFIC/HGS/CCNT1/TSG101/SAMHD1/NELFCD/NELFA/SUPT5H/VPS4A/CCNT2/MX2/CDK9/CHMP6/RANBP2/CPSF7/APOBEC3A/APOBEC3G	2.89948174142681
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	48/2138	148/9376	1.42229413698076	CDKN1A/GADD45A/TCF7L2/WNT7A/NOTCH2/NCOA1/AXIN2/FZD1/SP1/MAPK3/PIK3R1/BRCA1/SOS1/BAX/RAF1/ERBB2/IGF1R/DDB2/BRCA2/MAP2K1/FZD6/RB1/FRAT2/RPS6KB1/TCF7/MAPK1/E2F2/JAG2/PIK3CA/NFKB2/MTOR/TCF7L1/KRAS/ARAF/APC/FZD7/WNT6/EGFR/PIK3R2/NOTCH1/WNT5B/FZD3/FZD8/PIK3R3/WNT11/FRAT1/DLL1/FOS	2.81431247550433
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	72/2138	238/9376	1.32667772441062	RPS4Y1/RPL26/RPS10/RPL27A/RPS8/RPL10A/RPS15A/RPS11/RPS27L/RPS21/C1QB/RPS12/RPL17/IL6ST/NRP1/NFKBIA/RPL36A/RPL9/C1QA/RPL13A/C5AR1/SYK/RPL23/RPS20/ADAM17/RPL7/MAPK3/PIK3R1/C1QC/IL1B/RPL31/RPS25/CYBB/NFKB1/JAK1/MAP3K7/C3AR1/FCGR2A/HBEGF/IFNAR1/MAPK1/MX2/RPS17/IRAK4/IKBKG/PIK3CA/TAB2/CXCL10/OAS2/RPL41/CASP1/TRAF3/TLR4/IKBKB/TYK2/IKBKE/CHUK/EGFR/TLR3/C2/PIK3R2/MAVS/IL6R/TRAF6/IFIH1/TNF/MAPK8/PIK3R3/NLRP3/PLCG1/FOS/VWF	2.77435877549133
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	24/2138	63/9376	1.67063120851708	PLOD2/ASH1L/SMYD3/PRDM2/AADAT/DHTKD1/KMT2C/PIPOX/EZH2/PLOD3/HADH/NSD1/DOT1L/ALDH9A1/SETD1B/SETD2/EHMT2/PRDM16/SETD1A/SETDB1/SUV39H1/KMT2D/SETDB2/TMLHE	2.90261498093237
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	43/2138	130/9376	1.4505576743182	CREB5/COL4A1/COL4A2/NFKBIA/TGFBR1/MMP9/MAPK3/PIK3R1/ATF6B/NOS2/GNG12/SOS1/RAF1/NFKB1/CREB3L4/CREB3L2/GNG4/SMAD2/MAP2K1/MAPK1/MAP2K7/PIK3CA/CREB1/ATF2/KRAS/ADCY7/ARRB2/MAP2K4/EGFR/PIK3R2/GNA15/TGFB1/PLCB1/ADCY6/GNG10/ADCY9/MAPK8/PIK3R3/GNGT1/FOS/ARRB1/PRKACB/VEGFA	2.8114173603475
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	50/2138	156/9376	1.4055791417812	CDKN1A/CLDN19/RXRA/YWHAG/NFKBIA/CLDN23/MAPK3/PIK3R1/SOS1/BAX/YWHAZ/RAF1/NFKB1/JAK1/PPP2CA/MAP2K1/PPP2CB/FADD/RB1/IFNAR1/MAPK1/E2F2/CFLAR/RIPK1/MX2/IKBKG/PIK3CA/CXCL10/KRAS/ARAF/OAS2/SCARB1/TRAF3/RNASEL/CLDN14/IKBKB/TYK2/IKBKE/CHUK/EGFR/TLR3/PIK3R2/BID/PPARA/RSAD2/MAVS/PIAS1/TRAF6/TNF/PIK3R3	2.77621214513609
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	18/2138	44/9376	1.79403010460073	ARHGDIB/CREB5/VAMP2/RAB5B/DCTN4/DYNC1I2/RAB11B/STX4/CREB3L4/CREB3L2/DCTN1/RAB5A/DYNC1LI2/DYNLL2/CREB1/ADCY6/ADCY9/PRKACB	2.86916907285558
Human Diseases	Infectious disease: viral	hsa05162	Measles	44/2138	136/9376	1.41880812193914	CD46/NFKBIA/CCNE1/PIK3R1/IL1B/BAX/TNFAIP3/NFKB1/JAK1/MAP3K7/CDKN1B/CSNK2A2/FADD/IFNAR1/BBC3/MX2/HSPA6/MSN/IRAK4/IKBKG/PIK3CA/TAB2/CCNE2/IL2RG/OAS2/TRAF3/TLR4/IKBKB/IL2RB/TYK2/IKBKE/CHUK/PIK3R2/BID/MAVS/RAB9B/TRAF6/IFIH1/MAPK8/PIK3R3/STAT5A/FOS/HSPA1B/JAK3	2.67379904095989
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	29/2138	82/9376	1.55093659449223	HLA-DRA/HLA-B/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/TAPBPL/CTSB/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-A/HLA-DMB/TAPBP/HLA-DQA2/LGMN/HLA-DRB5/CD4/NFYB/HLA-F/NFYC/HSPA6/IFI30/CREB1/CTSL/NFYA/TNF/HSPA1B	2.72324936823792
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	45/2138	140/9376	1.40959508218629	SPP1/SERPINE1/PRKAG2/GNAQ/ITPR2/TGFBR1/PRKAB2/SMAD4/MAPK3/NOS2/GNG12/RAF1/ITPR3/GNG4/GNA13/SMAD2/MAP2K1/RPS6KB1/RRAS2/MAPK1/SLC9A1/PRKCE/MTOR/KRAS/PDE3B/PRKAA1/ADCY7/MAP1LC3B/MRAS/PIK3C3/PRKAB1/NRF1/PIK3R5/PLCB1/ADCY6/KLF2/GNG10/SMAD3/MEF2A/ADCY9/EGR1/HDAC4/SPHK2/GNGT1/PRKACB	2.65373155510053
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	34/2138	100/9376	1.4910383536015	CCR1/CXCR4/CXCL2/IL6ST/CXCL3/ACKR3/CCL3/IL10RB/CSF1R/TNFRSF14/IL18/CCL18/IL10RA/CCL20/CXCL9/CXCL10/IL2RG/CCL5/IL2RB/TNFRSF10A/TNFRSF10D/IL20RA/TNFRSF1B/TNFSF10/CCL7/TNFRSF10B/IL6R/TNF/TNFRSF10C/XCL1/IL34/CXCR2/CCL28/XCR1	2.6829664640936
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	34/2138	100/9376	1.4910383536015	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/CSF2RA/HLA-DMA/ITGA6/CSF3R/HLA-DMB/CD59/MME/CD36/CD37/HLA-DQA2/CD44/CSF1R/HLA-DRB5/IL1B/CD4/FCGR1A/TFRC/ITGAM/CD22/ITGA3/ITGA2/ITGA5/CD33/IL6R/TNF/IL4R/IL7R/ITGA2B	2.6829664640936
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	14/2138	32/9376	1.91861552853134	GABARAP/GABARAPL2/PPP2CA/PPP2CB/GABARAPL1/MLST8/ATG13/MTOR/ATG7/PIK3C3/ATG16L1/ULK2/ATG2B/RPTOR	2.8289323113998
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	14/2138	32/9376	1.91861552853134	BCL2L11/XIAP/BAX/PMAIP1/FADD/BIRC6/BBC3/CASP7/BIRC2/DIABLO/BIRC7/BIRC3/BID/MAPK8	2.8289323113998
Human Diseases	Immune disease	hsa05310	Asthma	14/2138	32/9376	1.91861552853134	HLA-DRA/PRG2/HLA-DPA1/HLA-DRB1/HLA-DPB1/FCER1G/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-DMB/HLA-DQA2/HLA-DRB5/CD40/TNF	2.8289323113998
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	23/2138	62/9376	1.62684450345514	MAML2/EP300/NOTCH2/TLE6/TLE4/TLE3/NCSTN/ADAM17/CREBBP/ATXN1/RBPJ/SPEN/DTX4/PSEN1/NCOR2/MAML1/JAG2/NUMB/LFNG/ATXN1L/NOTCH1/DLL1/PSEN2	2.69133493780769
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	17/2138	42/9376	1.7750456590494	SLC39A8/HMOX1/GPX4/FTL/LPCAT3/CYBB/ACSL5/NCOA4/GSS/TFRC/PRNP/PCBP1/ACSL1/ATG7/GCLC/MAP1LC3B/SAT1	2.73588749475022
Human Diseases	Immune disease	hsa05330	Allograft rejection	16/2138	39/9376	1.79914130147994	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/CD86/CD40/TNF	2.71789328064617
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	35/2138	105/9376	1.46180230745245	FOXO3/GABARAP/FIS1/GABARAPL2/RAB5B/SP1/CCZ1B/HUWE1/HIF1A/RAB5A/CSNK2A2/SIAH1/GABARAPL1/RRAS2/USP8/MON1B/TBC1D15/MUL1/NBR1/ARIH1/KRAS/OPTN/MFN2/EIF2AK3/PINK1/SQSTM1/MAP1LC3B/MRAS/TBC1D17/ULK1/MAPK8/MTX3/TFE3/MITF/AMBRA1	2.58623304698575
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	23/2138	63/9376	1.60102157482887	RPA1/PCNA/RFC3/POLR2K/XPC/RFC1/RFC2/RPA2/LIG1/POLE3/DDB2/POLD4/POLE/POLR2M/DDB1/POLD1/POLE2/ERCC4/ERCC5/RBX1/POLR2J3/RPA4/UVSSA	2.60133170780913
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	70/2138	238/9376	1.28982556539922	IGF2/RASGRF2/ETS2/TIAM1/REL/KSR1/RASA1/EFNA1/RAB5B/CSF1R/RASAL2/MAPK3/PIK3R1/GNG12/RALGDS/SOS1/RAF1/RASGRF1/NFKB1/IGF1R/GNG4/RAB5A/PAK2/MAP2K1/ARF6/RASSF1/RRAS2/MAPK1/PLD1/SHOC2/GAB1/IKBKG/PIK3CA/RGL2/NF1/ABL2/FGFR3/EXOC2/KRAS/RAC2/EFNA5/RAP1B/IKBKB/CHUK/EGFR/RASA2/PDGFA/PIK3R2/PLCE1/MET/RALGAPA1/RALGAPB/MRAS/RASSF5/RASGRP3/PDGFB/RALGAPA2/GNG10/MAPK8/PIK3R3/PLA2G6/LAT/ANGPT2/PLCG1/GNGT1/RIN1/RGL1/EFNA2/PRKACB/VEGFA	2.46138637759198
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	27/2138	78/9376	1.5180254731237	ITGB2/C1QB/LY96/C1QA/MAPK3/NOS2/C1QC/IL1B/NFKB1/ITGAM/SERPING1/IRF1/MAPK1/ITGB1/PYCARD/IRAK4/CASP7/CASP1/TLR4/ITGA5/C2/TRAF6/TNF/MAPK8/NLRP3/NOD1/FOS	2.49680051778089
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	14/2138	34/9376	1.80575579155891	PRKAG2/PRKAB2/CRY1/FBXL3/CUL1/CLOCK/PER2/CREB1/PRKAA1/NR1D2/FBXW11/RBX1/PRKAB1/DBP	2.55801544331768
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	51/2138	168/9376	1.33128424428705	FTL/GLUL/CAMK2G/CHMP3/VPS4B/XIAP/IL1B/STAT6/CHMP4C/BAX/TNFAIP3/CYBB/IFNGR1/JAK1/TRPM7/CAPN2/CHMP1A/CHMP1B/FADD/IFNAR1/VPS4A/CFLAR/GLUD1/RIPK1/CHMP6/PYCARD/CYLD/BIRC2/CASP1/TLR4/BIRC3/SQSTM1/TNFRSF10A/TYK2/TLR3/STAT4/TNFSF10/BID/CAMK2D/TNFRSF10B/TNF/PYGB/SMPD1/MAPK8/SPATA2L/MLKL/NLRP3/STAT5A/USP21/JAK3/JAK2	2.35479424825164
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	60/2138	203/9376	1.29617938591843	SPP1/FN1/ITGA6/COL4A1/LAMC1/COL4A2/VAV3/TLN2/LAMA5/ITGB4/EMP2/MAPK3/PIK3R1/XIAP/ITGB6/PDPK1/PTK2/SOS1/RAF1/ERBB2/LAMC2/RASGRF1/IGF1R/RAPGEF1/CAPN2/CRK/PAK2/MAP2K1/PARVG/MAPK1/VCL/VAV2/CRKL/ITGB1/PPP1CC/PIK3CA/BIRC2/ITGAV/PIP5K1A/PPP1R12B/RAC2/COL9A3/ITGA3/LAMB4/ITGA2/BIRC3/RAP1B/EGFR/ITGA5/PDGFA/PIK3R2/MET/PDGFB/LAMB3/MAPK8/PIK3R3/VAV1/ITGA2B/VWF/VEGFA	2.31860810571882
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	28/2138	83/9376	1.47941438344585	NFKBIA/ZCCHC3/POLR2K/IL1B/IL18/IFI16/NFKB1/SAMHD1/FADD/POLR3K/RIPK1/TREX1/PYCARD/IKBKG/CASP7/CXCL10/G3BP1/POLR3A/CASP1/PCBP1/CCL5/IKBKB/IKBKE/CHUK/MAVS/POLR3F/MLKL/NLRP3	2.38425299313384
NA	NA	hsa04518	Integrin signaling	47/2138	154/9376	1.3384034113688	SPP1/FBN1/FN1/ITGB2/ITGA6/COL4A1/LAMC1/COL4A2/FERMT1/TLN2/LIMS2/LAMA5/ITGB4/ITGAX/PIK3R1/ITGB6/PTK2/ICAM1/ERBB2/LAMC2/IGF1R/ITGAM/FERMT3/PARVG/VCL/ITGB1/PIK3CA/ITGAV/MTOR/RAC2/COL9A3/ITGA3/LAMB4/ITGA2/ITGAL/EGFR/ITGA5/PDGFA/PIK3R2/MET/TGFB1/PDGFB/LAMB3/PIK3R3/ITGA2B/VWF/VEGFA	2.30124433889625
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/2138	19/9376	2.07729801585348	HGSNAT/HEXA/GUSB/NAGLU/IDS/GNS/GALNS/SGSH/HYAL4	2.55460962985836
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	21/2138	59/9376	1.56090754863566	UPP1/RRM1/NME3/NME6/TK2/NT5C3A/ENTPD4/RRM2B/CANT1/DCTPP1/DCK/CMPK2/CTPS2/NT5E/DPYD/NT5C2/CAD/AK9/DUT/ENTPD1/ENTPD5	2.34887249321032
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	35/2138	110/9376	1.39535674802279	SERPINE1/CDKN1A/EPAS1/HMOX1/EP300/CAMK2G/MAPK3/PIK3R1/NOS2/CREBBP/ERBB2/CYBB/HIF1A/NFKB1/IFNGR1/IGF1R/CDKN1B/MAP2K1/TFRC/RPS6KB1/MAPK1/PIK3CA/VHL/MTOR/TLR4/EGFR/PIK3R2/CAMK2D/RBX1/ENO3/IL6R/PIK3R3/ANGPT2/PLCG1/VEGFA	2.26683312184341
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	39/2138	125/9376	1.36824695977549	FCER1G/CTSD/CERS6/GNAQ/MAPK3/PIK3R1/PDPK1/BAX/RAF1/CERS2/NFKB1/SPTSSA/MAP3K5/PPP2CA/ASAH1/GNA13/MAP2K1/PPP2CB/PPP2R5E/SGPP1/MAPK1/PLD1/PIK3CA/PRKCE/KRAS/RAC2/SPTLC2/SGMS2/PIK3R2/BID/NSMAF/PLCB1/TNF/SMPD1/MAPK8/ADORA1/PIK3R3/SPHK2/ACER2	2.25257902217332
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	32/2138	99/9376	1.41750526783268	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/ITGB2/FCGR3A/KRT14/HLA-DMB/C1QB/C1QA/C5AR1/FPR3/HLA-DQA2/HLA-DRB5/C1QC/FCGR1A/ICAM1/C3AR1/FCGR2A/ITGAM/KRT16/FPR1/PTAFR/KRT9/ITGAL/C2/SELPLG/FCGR3B/KRT15	2.26963477886922
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	34/2138	107/9376	1.39349378841261	CREB5/PRKAG2/FBP1/GNAQ/ITPR2/EP300/FOXO1/PHKA2/CAMK2G/PRKAB2/CREBBP/PPP3R1/CREB3L4/ITPR3/CREB3L2/PPP3CA/PHKB/PPP3CB/CREB1/ATF2/PCK2/PDE3B/PRKAA1/SIK2/CRTC2/PPARA/CAMK2D/SIRT1/PRKAB1/PLCB1/CPT1A/PYGB/CPT1B/PRKACB	2.22481307468421
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	50/2138	168/9376	1.30518063165397	CSH2/CDKN1A/CSH1/CSF2RA/PIM1/CSF3R/IL6ST/EP300/CSF2RB/IL10RB/PIK3R1/CREBBP/OSM/STAT6/SOS1/RAF1/IL10RA/IFNGR1/JAK1/OSMR/IL13RA1/CSHL1/IFNAR1/GH2/PTPN6/PIK3CA/MTOR/STAM/IL2RG/IL27/IL2RB/TYK2/EGFR/STAT4/IL20RA/PDGFA/PIAS3/PIK3R2/CISH/PDGFB/PIAS1/IL6R/LEPR/MCL1/PIK3R3/STAT5A/IL4R/IL7R/JAK3/JAK2	2.16924773359849
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	47/2138	157/9376	1.31282882389041	SERPINE1/ITGB2/TCF7L2/PARD6G/YWHAG/WNT7A/TGFB2/TGFBR1/WWTR1/BMPR2/AXIN2/FZD1/SMAD4/YWHAZ/TEAD3/RASSF6/SMAD1/PPP2CA/DLG1/SMAD2/FZD6/PPP2CB/RASSF1/TCF7/BBC3/PPP1CC/STK3/BIRC2/LATS1/TCF7L1/APC/FZD7/BIRC3/WNT6/TEAD1/SMAD7/FBXW11/MOB1B/LLGL2/TGFB1/AJUBA/WNT5B/FZD3/SMAD3/FZD8/WNT11/AMOT	2.1482997597274
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	42/2138	138/9376	1.33468906332615	ANAPC13/YWHAG/ITPR2/CAMK2G/CCNE1/MAPK3/PKMYT1/CPEB2/ANAPC16/YWHAZ/PPP3R1/CDC23/ITPR3/RPS6KA3/IGF1R/PPP2CA/CDK1/MAD2L2/PPP3CA/MAP2K1/PPP2CB/FBXO5/ANAPC5/PPP2R5E/MAPK1/CUL1/PPP3CB/PPP1CC/MAD2L1/CCNE2/SMC1B/ANAPC7/SMC3/ADCY7/FBXW11/CAMK2D/RBX1/BUB1/ADCY6/ADCY9/STAG3/PRKACB	2.15264435485905
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	32/2138	101/9376	1.38943585658847	TCF7L2/GNAQ/WNT7A/EP300/CAMK2G/FZD1/MAPK3/CREBBP/RAF1/CREB3L4/CREB3L2/MAP2K1/FZD6/TCF7/MAPK1/CREB1/TCF7L1/KRAS/FZD7/ADCY7/WNT6/CAMK2D/WNT5B/PLCB1/ADCY6/FZD3/MC1R/ADCY9/FZD8/WNT11/MITF/PRKACB	2.13855223670636
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/2138	37/9376	1.65934315981089	CDKN1A/GADD45A/TCF7L2/RXRA/MAPK3/BAX/RXRB/NCOA4/DDB2/MAP2K1/TCF7/MAPK1/TCF7L1/KRAS	2.18394842787852
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/2138	44/9376	1.59469342631176	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-DRB5/IL1B/HLA-F/CD86/TNF	2.1488807246952
Human Diseases	Cancer: specific types	hsa05218	Melanoma	24/2138	73/9376	1.44177761830926	CDKN2A/CDKN1A/GADD45A/MDM2/MAPK3/PIK3R1/BAX/RAF1/IGF1R/DDB2/MAP2K1/RB1/MAPK1/E2F2/PIK3CA/KRAS/ARAF/EGFR/PDGFA/PIK3R2/MET/PDGFB/PIK3R3/MITF	2.05936737542366
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	9/2138	21/9376	1.87946010958172	BCAT2/PPCDC/AASDHPPT/PANK3/DPYD/PANK2/PANK1/BCAT1/CSAD	2.19272463701086
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	53/2138	184/9376	1.2631878635051	CXCR4/PARD6G/DPYSL2/NRP1/BMPR2/LIMK2/RASA1/EFNA1/CAMK2G/SSH2/MAPK3/SEMA4C/PIK3R1/EFNB2/PDPK1/PTK2/RAF1/PPP3R1/NTN4/SEMA3C/PPP3CA/PAK2/RYK/NFATC3/PLXNC1/MAPK1/PPP3CB/EFNB1/ITGB1/SSH3/PIK3CA/PLXNB2/ARHGEF12/KRAS/RAC2/EFNA5/SEMA4A/PIK3R2/MET/CAMK2D/SSH1/WNT5B/EPHB2/PLXNB1/FZD3/LRIG2/SEMA3A/RHOD/PIK3R3/PLCG1/EFNA2/RGS3/PLXNA2	1.95952117767655
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/2138	45/9376	1.55925579461594	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-DRB5/IL1B/HLA-F/CD86/TNF	2.04377392528809
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	32/2138	104/9376	1.34935597610995	MBOAT7/GPCPD1/DGKH/AGPAT1/CHKB/LPCAT1/PCYT2/LYPLA1/LPCAT3/CEPT1/PLD3/GPD2/PLB1/CHPT1/LPIN2/CDS1/PLD1/ETNK1/LCAT/MBOAT1/SGMS2/PLA2G15/LPIN1/LPCAT2/GPAM/PGS1/GNPAT/DGKA/GPD1L/GDPD5/PLA2G6/ADPRM	1.9470555137715
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	29/2138	93/9376	1.36749248116519	MAP2K3/GNAQ/ITPR2/MAP3K2/CAMK2G/MAPK3/SOS1/GNA11/RAF1/ITPR3/MAP2K1/HBEGF/MAP3K1/MAPK1/PLD1/MAP2K7/MAP3K3/KRAS/ADCY7/MAP2K4/EGFR/CAMK2D/PLCB1/ADCY6/MAPK7/ADCY9/MAPK8/EGR1/PRKACB	1.93564609712732
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	20/2138	60/9376	1.46180230745245	MAPK3/PIK3R1/PTK2/RAF1/PPP3R1/PPP3CA/MAP2K1/MAPK1/PPP3CB/PIK3CA/KRAS/RAC2/PTGS2/PIK3R2/MAPKAPK3/PIK3R3/PLCG1/SPHK2/HSPB1/VEGFA	1.950280969918
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	17/2138	50/9376	1.4910383536015	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/CXCR4/HLA-DMB/HLA-DQA2/TNFSF13B/HLA-DRB5/CD86/CD40/TGFB1/CCL28/ICOSLG	1.89205131467461
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	8/2138	19/9376	1.84648712520309	GLDC/DHTKD1/OGDH/DBT/LIAS/AMT/BCKDHB/BCKDHA	2.00728501284926
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	11/2138	29/9376	1.66343021192865	WWTR1/RASSF2/TEAD3/RASSF6/RASSF1/RASSF4/STK3/LATS1/TEAD1/MOB1B/AJUBA	1.94463600206733
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	12/2138	33/9376	1.59469342631176	SNAP23/VAMP2/VAMP7/STX7/VAMP8/STX4/STX11/GOSR1/STX3/STX16/STX17/STX1A	1.85988945723923
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	40/2138	139/9376	1.26198760355607	CREB5/KRT14/CTSD/GNAQ/ITPR2/NCOA1/MMP9/SP1/MAPK3/PIK3R1/ATF6B/NCOA2/SOS1/RAF1/CREB3L4/ITPR3/CREB3L2/MAP2K1/KRT16/HBEGF/MAPK1/HSPA6/PIK3CA/CREB1/ATF2/KRAS/ADCY7/KRT9/EGFR/PIK3R2/PLCB1/ADCY6/GABBR2/ADCY9/RARA/PIK3R3/FOS/HSPA1B/KRT15/PRKACB	1.69123076366993
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	11/2138	30/9376	1.60798253819769	SHMT1/IL1B/NFKB1/ABCC3/IKBKG/DHFR/MTHFR/IKBKB/FOLR1/CHUK/TNF	1.81267124059363
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	58/2138	212/9376	1.1997811391355	ITGB2/PARD6G/MAP2K3/GNAQ/VAV3/TIAM1/TLN2/EFNA1/CSF1R/MAPK3/PIK3R1/APBB1IP/RALGDS/RAF1/LCP2/IGF1R/KRIT1/RAPGEF2/RAPGEF1/CRK/MAP2K1/ITGAM/FPR1/MAPK1/VAV2/CRKL/ITGB1/PIK3CA/FGFR3/KRAS/RAC2/EFNA5/ADCY7/RAP1B/ITGAL/EGFR/PRKD2/PDGFA/PIK3R2/PLCE1/DOCK4/MET/MRAS/RASSF5/RASGRP3/PDGFB/PLCB1/ADCY6/RAPGEF6/ADCY9/PIK3R3/VAV1/LAT/ANGPT2/PLCG1/ITGA2B/EFNA2/VEGFA	1.59904274968088
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	21/2138	67/9376	1.37453052790305	GNAQ/ITPR2/EP300/CAMK2G/MAPK3/CREBBP/RAF1/PPP3R1/ITPR3/RPS6KA3/PPP3CA/MAP2K1/MAPK1/PPP3CB/PPP1CC/KRAS/ARAF/RAP1B/CAMK2D/PLCB1/PRKACB	1.67206558499733
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	34/2138	117/9376	1.27439175521495	SMARCA1/MORF4L2/BRD7/RBBP4/ARID1A/MBD3/RBBP7/BAZ2B/CHD4/SMARCE1/BRD8/SMARCD2/PBRM1/ING3/EPC1/POLE3/CHD3/EPC2/BAZ2A/PHF6/RSF1/SRCAP/YEATS4/INO80D/BPTF/INO80E/SMARCD1/GATAD2B/ARID2/PHF10/MORF4L1/BCL7A/SS18L1/TRRAP	1.62316304278761
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	18/2138	56/9376	1.40959508218629	MAN1A1/FUT8/MAN2A1/GANAB/MGAT4A/ALG8/DPM2/MGAT2/MGAT5/ALG6/ALG12/ST6GAL1/DHRSX/ALG10/ALG11/MAN1C1/MAN2A2/ALG10B	1.67078662584552
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	42/2138	149/9376	1.23615497140274	FCER1G/SYK/TSC1/DGKH/AGPAT1/MAPK3/PIK3R1/RALGDS/SOS1/RAF1/GNA13/MAP2K1/ARF6/DNM2/RRAS2/MAPK1/PLD1/CYTH2/GAB1/PIK3CA/RHEB/PIP5K1A/MTOR/KRAS/CYTH3/ADCY7/EGFR/PDGFA/CYTH1/PIK3R2/MRAS/PIK3R5/PDGFB/PLCB1/ADCY6/CXCR2/ADCY9/CYTH4/DGKA/PIK3R3/PLCG1/SPHK2	1.57921101915935
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	24/2138	79/9376	1.33227552071615	CLTB/SLC17A8/VAMP2/SLC6A2/ATP6V0D1/AP2B1/ATP6V1G1/ATP6V1E1/SLC1A3/AP2A2/ATP6V1A/ATP6V1H/NAPA/ATP6V1D/ATP6V1C1/DNM2/STX3/ATP6V0E1/SLC6A4/SYT1/ATP6V0A1/STXBP1/CPLX1/STX1A	1.61183535150609
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2138	38/9376	1.50027078922751	NMNAT2/NAMPT/QPRT/NMRK1/NADK/NT5E/NT5C2/SIRT1/SIRT5/NNT/NMRK2/NADSYN1/NMNAT1	1.67938476081531
Organismal Systems	Immune system	hsa04611	Platelet activation	36/2138	126/9376	1.25297340638781	FCER1G/SNAP23/GNAQ/ITPR2/TLN2/SYK/MAPK3/PIK3R1/VAMP8/APBB1IP/LCP2/ITPR3/GNA13/FCGR2A/FERMT3/MAPK1/ITGB1/PPP1CC/TBXAS1/PIK3CA/ARHGEF12/PRKG1/ITGA2/ADCY7/RAP1B/BTK/PIK3R2/STIM1/PIK3R5/PLCB1/ADCY6/ADCY9/PIK3R3/ITGA2B/VWF/PRKACB	1.55370825853657
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/2138	57/9376	1.38486534390232	ACAA2/ACOX1/ELOVL4/FASN/ELOVL5/ACADVL/SCP2/ACSL5/MECR/HADH/ELOVL1/PPT1/CBR4/HSD17B8/ACSL1/PPT2/CPT1A/CPT1B	1.58395112613466
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/2138	21/9376	1.67063120851708	DSE/XYLT1/B3GAT3/CHST14/CHST11/CHPF2/B4GALT7/CHST15	1.67205943423991
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	20/2138	65/9376	1.34935597610995	CREB5/GNAQ/ITPR2/SP1/ATF6B/GNA11/CREB3L4/ITPR3/CREB3L2/CREB1/NCEH1/ATF2/SCARB1/ADCY7/PDE8A/PLCB1/ADCY6/ADCY9/PRKACB/CACNA1G	1.53605544087284
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	20/2138	65/9376	1.34935597610995	SPP1/GNAQ/KISS1/ITPR2/MAPK3/PIK3R1/GNA11/RAF1/ITPR3/MAP2K1/MAPK1/PIK3CA/KRAS/ARRB2/PIK3R2/PLCB1/GABBR2/PIK3R3/ARRB1/CACNA1G	1.53605544087284
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	7/2138	18/9376	1.70543602536119	FASN/ACSL5/MECR/OLAH/CBR4/HSD17B8/ACSL1	1.62810558434719
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	25/2138	85/9376	1.28982556539922	UPP1/RRM1/NME3/LACC1/NME6/TK2/NT5C3A/ENTPD4/GDA/RRM2B/CANT1/DCTPP1/DCK/CMPK2/CTPS2/NT5E/NT5C2/AK5/AK9/GMPR/AMPD2/DUT/AMPD3/ENTPD1/ENTPD5	1.45879788112984
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	26/2138	89/9376	1.28113011214934	SPP1/FN1/ITGA6/COL4A1/LAMC1/COL4A2/CD36/DAG1/LAMA5/ITGB4/CD44/HMMR/ITGB6/LAMC2/SDC4/ITGB1/ITGAV/COL9A3/ITGA3/LAMB4/ITGA2/ITGA5/AGRN/LAMB3/ITGA2B/VWF	1.44825436340779
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/2138	51/9376	1.37581393642583	ATP6V0D1/ATP6V1G1/TJP2/TJP1/ATP6V1E1/ATP6V1A/ATP6V1H/ATP6V1D/ATP6V1C1/ATP6AP1/ATP6V0E1/ATP6V0A1/KCNQ1/ADCY9/PLCG1/PRKACB	1.46256019061629
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	19/2138	63/9376	1.32258304007602	CDKN1A/GADD45A/TCF7L2/WNT7A/AXIN2/FZD1/BAX/GLI3/DDB2/FZD6/TCF7/TCF7L1/APC/FZD7/WNT6/WNT5B/FZD3/FZD8/WNT11	1.39619861531619
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	77/2138	298/9376	1.13314205711918	CSH2/CSH1/EBI3/CSF2RA/CCR1/CXCR6/IL1RAP/CXCR4/GDF15/CSF3R/CXCL2/CXCL16/IL6ST/TGFB2/TGFBR1/CXCL3/ACKR3/CCL3/BMPR2/CSF2RB/IL10RB/IL17RE/TNFSF13B/CSF1R/IL1RN/INHA/TNFRSF14/IL1B/CD4/OSM/IL18/CCL18/IL10RA/IFNGR1/CCL20/OSMR/IL13RA1/CXCL9/CSHL1/IFNAR1/ACVR2B/CD40/GH2/CXCL10/TNFRSF12A/IL2RG/IL27/CCL5/EDA2R/IL2RB/TNFRSF10A/ACVR1/RELL2/TNFRSF10D/IL20RA/TNFRSF1B/TNFSF10/CCL7/RELL1/TGFB1/TNFRSF10B/RELT/IL6R/LEPR/TNF/TNFRSF10C/IL17RC/XCL1/IL34/CXCR2/TNFSF12/ACVR2A/CCL28/IL4R/IL7R/TNFRSF18/XCR1	1.26942926111515
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	32/2138	115/9376	1.22028714361248	CREB5/GNAQ/ITPR2/CAMK2G/MAPK3/PIK3R1/GNG12/GNA11/CREB3L4/ITPR3/CREB3L2/GNG4/CHRM5/MAP2K1/MAPK1/PIK3CA/CREB1/KRAS/ADCY7/PIK3R2/CAMK2D/PIK3R5/PLCB1/ADCY6/GNG10/KCNQ1/ADCY9/PIK3R3/GNGT1/FOS/JAK2/PRKACB	1.29178229820892
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	21/2138	72/9376	1.27907701902089	NFKBIA/NFKB1/MAP3K7/FADD/MAP3K1/RIPK1/IKBKG/CYLD/CXCL10/TRIM25/TRAF3/ZNFX1/IKBKB/IKBKE/CHUK/MAVS/RNF125/TRAF6/IFIH1/TNF/MAPK8	1.29192015012339
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	22/2138	76/9376	1.26945989857713	FABP7/RXRA/ACOX1/CD36/OLR1/LPL/CYP27A1/PDPK1/FABP4/SCP2/RXRB/ACSL5/PPARD/FABP5/PCK2/SLC27A1/GK/ACSL1/PPARA/CPT1A/FABP3/CPT1B	1.28185724721862
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	12/2138	38/9376	1.38486534390232	MAPK3/PIK3R1/PDPK1/ATP1B1/SGK1/MAPK1/PIK3CA/NEDD4L/KRAS/NR3C2/PIK3R2/PIK3R3	1.29197428159563
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/2138	31/9376	1.41464739430882	GLDC/GLUL/AGXT/SHMT1/HYI/MCEE/CAT/ACO1/CS/AMT	1.25675416698616
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	30/2138	110/9376	1.19602006973382	ANAPC13/MAPK3/PIK3R1/PKMYT1/CPEB2/ANAPC16/RAF1/CDC23/RPS6KA3/IGF1R/CDK1/MAD2L2/MAP2K1/ANAPC5/MAPK1/KIF22/PIK3CA/MAD2L1/KRAS/ARAF/ANAPC7/PDE3B/ADCY7/PIK3R2/BUB1/ADCY6/ADCY9/MAPK8/PIK3R3/PRKACB	1.12390844178297
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/2138	78/9376	1.23690964476746	FN1/CLTB/PIK3R1/HCLS1/PTK2/ARPC2/MAD2L2/CRK/DNM2/VCL/CRKL/ITGB1/GAB1/PIK3CA/WASL/WASF2/ITGA5/PIK3R2/MET/WASF1/ELMO2/PIK3R3	1.14186686642227
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/2138	24/9376	1.46180230745245	XYLT1/B3GAT3/EXTL3/EXT2/NDST1/B4GALT7/GLCE/NDST2	1.23108962021024
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/2138	28/9376	1.40959508218629	ACAA2/ELOVL4/ELOVL5/MECR/HADH/ELOVL1/PPT1/PPT2/ACOT2	1.17965386971552
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	20/2138	71/9376	1.23532589362179	FOXO3/MAPK3/PIK3R1/SOS1/GALT/RAF1/NFKB1/TH/MAP2K1/IRF1/MAPK1/PIK3CA/KRAS/PIK3R2/CISH/MAPK8/PIK3R3/STAT5A/FOS/JAK2	1.08173504907183
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/2138	116/9376	1.17196219476791	CLDN19/ITGB2/CXCR4/ESAM/VAV3/CD99/NCF2/MMP9/CLDN23/PIK3R1/JAM2/PTK2/ICAM1/CYBB/ITGAM/VCL/VAV2/ITGB1/MSN/PIK3CA/CD99L2/RAC2/CDH5/RAP1B/CLDN14/ITGAL/PIK3R2/RASSF5/PIK3R3/VAV1/PLCG1	1.01283028751422
NA	NA	hsa03272	Virion - Hepatitis viruses	14/2138	48/9376	1.27907701902089	CLDN19/IST1/VPS4B/CLDN23/LAMP2/PDCD6IP/TSG101/DPP4/CHMP1A/CHMP1B/VPS4A/SCARB1/CLDN14/EGFR	1.05349050234879
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	15/2138	52/9376	1.26502122760308	APOE/APOC1/LRP1/MYLIP/CD36/SOAT1/LPL/CYP27A1/LIPA/ABCA1/NPC1/NCEH1/LIPG/LCAT/SCARB1	1.04150509774092
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	44/2138	170/9376	1.13504649755131	CLDN19/PRKAG2/AMOTL2/PARD6G/TIAM1/PCNA/MICALL2/PRKAB2/TJP2/SYNPO/CLDN23/TJP1/JAM2/SYMPK/ARHGEF2/HCLS1/ERBB2/ARPC2/MAP3K5/RAPGEF2/PPP2CA/DLG1/PPP2CB/NEDD4/RUNX1/MAP3K1/MAP2K7/ITGB1/MSN/PRKCE/WAS/NEDD4L/STK11/PRKAA1/CLDN14/TJAP1/MARVELD2/LLGL2/PRKAB1/RAPGEF6/MAPK8/TUBA4A/AMOT/PRKACB	0.965722833239155
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/2138	60/9376	1.24253196133458	GNAQ/ITPR2/MAPK3/GNA11/RAF1/ITPR3/IGF1R/PPP2CA/GNA13/MAP2K1/CRH/PPP2CB/MAPK1/KRAS/PRKG1/ARAF/PLCB1	1.02425964780703
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	59/2138	233/9376	1.1104678472922	FBN1/FBLN1/FMNL2/FN1/SYNE1/BGN/ITGA6/COL4A1/DIAPH2/COL4A2/PKP2/SUN2/DAG1/TLN2/TNNI2/ITGB4/JUP/VIM/SUN1/TNNT3/ITGB6/CSRP2/SGCE/ATP1B1/SYNE2/DAAM1/TMEM43/PDLIM3/PLEC/SDC4/VCL/DSG2/ITGB1/ACTG2/PDLIM1/SYNE3/NEBL/ITGAV/FMNL1/COL9A3/ITGA3/ITGA2/FBN2/CAPZA1/ITGA5/SNTB1/SNTB2/SDC2/AGRN/ENO3/AMPD2/FMNL3/AMPD3/ACTA1/COL11A1/MYOZ1/LMOD3/ACTC1/ITGA2B	0.928003663704502
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	24/2138	89/9376	1.182581641984	GNAQ/ITPR2/MAP3K2/MAPK3/TJP1/SOS1/GNA11/RAF1/ITPR3/CDK1/MAP2K1/MAPK1/KRAS/PRKG1/ADCY7/EGFR/PDGFA/PDGFB/PLCB1/ADCY6/MAPK7/ADCY9/TUBA4A/PRKACB	0.940577505767256
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/2138	49/9376	1.25297340638781	GALNT6/GALNT7/GALNT3/PLOD3/C1GALT1/POGLUT1/FUT11/GALNT11/POFUT2/LFNG/ST6GAL1/OGT/POMT2/GALNT10	0.964899585022267
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/2138	18/9376	1.46180230745245	HEXA/MAN2B2/AGA/GBA2/ENGASE/MAN2C1	1.06581304129285
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/2138	18/9376	1.46180230745245	PRDX1/CD320/LMBRD1/HCFC1/TCN2/ZNF76	1.06581304129285
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	80/2138	323/9376	1.08616889717829	CDKN2A/TIMP3/CDKN1A/PIM1/HMOX1/ERBB3/TGFB2/FOXP1/EP300/BMPR2/SOX4/BMI1/NOTCH2/DICER1/MARCKS/IRS2/CD44/EFNA1/BCL2L11/ST14/MMP9/VIM/CCNE1/MDM2/MAPK3/PIK3R1/BRCA1/CREBBP/ZEB2/CCNG1/SOS1/RAF1/ERBB2/NFKB1/DNMT1/KIF23/EZH2/MDM4/CDKN1B/CRK/MAP2K1/ATM/RASSF1/MAPK1/E2F2/RPS6KA5/CRKL/PLAU/PIK3CA/FSCN1/PRKCE/FGFR3/MTOR/CCNE2/KRAS/CDCA5/EFNA5/APC/PTGS2/IKBKB/EGFR/ITGA5/PDGFA/PIK3R2/NOTCH1/MET/SIRT1/PDGFB/FZD3/MAPK7/RPTOR/MIR29A/HDAC4/MCL1/PIK3R3/TP63/PLCG1/EFNA2/VEGFA/BMF	0.856516502532644
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	11/2138	38/9376	1.26945989857713	PTPRC/BLNK/CD4/CD40/DCLRE1C/UNG/IKBKG/IL2RG/BTK/IL7R/JAK3	0.904563802375964
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/2138	54/9376	1.21816858954371	SDS/AMD1/MAT2A/LACC1/BCAT2/DNMT1/IL4I1/GSS/GOT2/MAT2B/TST/ENOPH1/SDSL/BCAT1/GCLC	0.873805459423268
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	15/2138	54/9376	1.21816858954371	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/CD86/CD40	0.873805459423268
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/2138	50/9376	1.22791393826006	ITGB2/LRP1/CD36/TGFB2/IL1B/IL18/ICAM1/CD40/TLR4/ITGAL/MET/TGFB1/SDC2/TNF	0.878189785695579
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	26/2138	99/9376	1.15172303011405	IL1RAP/MAP2K3/GNAQ/ITPR2/CAMK2G/PIK3R1/IL1B/ITPR3/PTGER4/PPP1CC/PIK3CA/PRKCE/ADCY7/PRKCH/PIK3R2/CAMK2D/HRH1/PLCB1/ADCY6/ADCY9/MAPK8/F2RL1/PIK3R3/PLA2G6/PLCG1/PRKACB	0.824794062335704
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	20/2138	75/9376	1.16944184596196	CREB5/GPX3/GNAQ/ITPR2/ATF6B/GPX8/ATP1B1/TTF2/CREB3L4/ITPR3/CREB3L2/CREB1/ATF2/ADCY7/SLC5A5/PLCB1/ADCY6/ADCY9/PRKACB/ASGR1	0.800694200550519
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/2138	55/9376	1.19602006973382	CERS6/B4GALT5/PSAP/HEXA/UGCG/CERS2/ASAH1/KDSR/SGPP1/SPTLC2/SGMS2/GBA2/SMPD1/SPHK2/ACER2	0.792375117842616
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	13/2138	47/9376	1.21298489341799	IRS2/MAPK3/PIK3R1/MAPK1/PIK3CA/PRKCE/MTOR/IKBKB/PIK3R2/TNF/MAPK8/PIK3R3/CACNA1G	0.795536998786348
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/2138	16/9376	1.37043966323667	HEXA/ST8SIA1/NAGA/A4GALT/GBGT1	0.805971614984444
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	36/2138	144/9376	1.09635173058934	PPIF/VLDLR/GNAQ/ITPR2/PUM1/ATXN2L/SP1/PIK3R1/PUM2/ATXN1/RBPJ/BEAN1/ATXN2/ITPR3/MAP3K5/TBP/ATP2A2/MCU/PIK3CA/PSMA6/ATG13/MTOR/ATG14/PSMA8/ATXN1L/PIK3R2/PIK3C3/CIC/NFYA/PLCB1/ULK2/ATG2B/ULK1/MAPK8/PIK3R3/AMBRA1	0.633246891933646
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	25/2138	98/9376	1.1187262557034	CREB5/GNAQ/ITPR2/NR4A2/CAMK2G/ATF6B/ATP1B1/GNA11/CREB3L4/ITPR3/CREB3L2/CREB1/PRKCE/DAGLB/ATF2/SCARB1/ADCY7/PRKD2/CAMK2D/PLCB1/ADCY6/CAMK1D/ADCY9/PRKACB/CACNA1G	0.642115013744722
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/2138	20/9376	1.3156220767072	GMDS/CYB5R1/UGP2/NPL/GNE/CYB5R2	0.767922625591003
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	8/2138	28/9376	1.25297340638781	ATP6V0D1/ATP6V1G1/ATP6V1E1/ATP6V1A/ATP6V1D/ATP6V1C1/ATP6V0E1/ATP6V0A1	0.72857578315546
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	93/2138	388/9376	1.05114134994648	APOE/SLC39A8/PPIF/LRP1/BACE2/MME/GNAQ/ITPR2/WNT7A/NDUFA13/SLC39A11/IRS2/NCSTN/LPL/AXIN2/FZD1/ADAM17/MAPK3/PIK3R1/NOS2/ADAM10/IL1B/MT-ND3/SDHD/RAF1/PPP3R1/CYBB/NFKB1/ITPR3/MAP3K5/PSEN1/SLC39A13/SLC39A9/MT-ND4L/CAPN2/PPP3CA/CHRM5/MAP2K1/FZD6/CSNK2A2/FADD/FRAT2/MAPK1/ATP2A2/MAP2K7/PPP3CB/NDUFS1/MCU/RTN3/IKBKG/PIK3CA/CASP7/PSMA6/SLC39A7/ATG13/MTOR/MAPT/KRAS/COX8A/ARAF/APC/FZD7/EIF2AK3/PTGS2/IKBKB/WNT6/ATG14/CHUK/RTN4/PSMA8/MT-ND2/PIK3R2/BID/PIK3C3/WNT5B/NOX4/PLCB1/ULK2/FZD3/TNF/ATG2B/ULK1/MAPK8/KLC4/FZD8/TUBA4A/PIK3R3/WNT11/UQCR10/FRAT1/PSEN2/BACE1/AMBRA1	0.559160800324545
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	32/2138	128/9376	1.09635173058934	PDE10A/RRM1/NME3/PDE6H/LACC1/PDE7A/NME6/ENTPD4/GDA/PDE6D/RRM2B/CANT1/DCK/NT5E/PDE3B/ADCY7/PDE4B/NT5C2/AK5/PDE8A/PDE4C/AK9/GMPR/AMPD2/PDE4A/ADCY6/AMPD3/ENTPD1/ENTPD5/ADCY9/ADPRM/ENPP4	0.596514208979638
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	27/2138	108/9376	1.09635173058934	EEF1A1/NUP153/NUP62/TNPO1/NUP214/DDX19A/CASC3/KPNA6/NUP160/RNPS1/IPO7/NUP50/NUP133/UPF2/NUP35/RANGAP1/XPOT/XPO7/POM121/NUP93/NUP210/RANBP2/NUP205/EEF1A2/XPO4/SUMO4/KPNA5	0.547341759473568
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2138	17/9376	1.28982556539922	CYP27A1/SCP2/HSD3B7/CYP39A1/AMACR	0.65001986338961
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/2138	59/9376	1.11493396331119	MGLL/IRS2/PIK3R1/FABP4/PIK3CA/PRKG1/PDE3B/ADCY7/PTGS2/PIK3R2/ADCY6/ADCY9/ADORA1/PIK3R3/PRKACB	0.481300751993714
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/2138	30/9376	1.16944184596196	IDH1/SDHD/ACLY/IDH3B/ACO1/OGDH/CS/PCK2	0.50518286600604
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	13/2138	51/9376	1.11784882334599	GDPD3/PAFAH1B2/LPCAT1/GDPD1/CEPT1/PLD3/PLB1/CHPT1/PLA2G7/PLD1/PAFAH2/LPCAT2/PLA2G6	0.458633863278327
NA	NA	hsa04519	Cadherin signaling	95/2138	404/9376	1.03122192481175	KRT14/TCF7L2/ANKRD6/CYFIP2/AMOTL2/MAP2K3/PKP2/YWHAG/VAV3/WNT7A/NFKBIA/WWTR1/EP300/NCSTN/KRT7/AXIN2/FZD1/JUP/VIM/MAPK3/TJP1/ADAM10/CREBBP/PTK2/FAT2/YWHAZ/DAAM1/RAF1/TEAD3/ERBB2/LHFPL2/NFKB1/TAOK1/CDH23/ARPC2/IGF1R/PSEN1/TMC1/TMC4/RYK/DSC3/MYO1F/MAP2K1/FZD6/RERE/KRT16/CDH18/TCF7/RRAS2/TAOK3/FAT1/MAPK1/MYO1D/SHOC2/VCL/DSG2/VAV2/PPP1CC/STK3/IKBKG/NCKAP1L/LATS1/TCF7L1/KRAS/RAC2/APC/CDH5/FZD7/IKBKB/WNT6/KRT9/CHUK/EGFR/VANGL1/TEAD1/GABRE/MOB1B/MET/MRAS/TMC7/AJUBA/WNT5B/FMN1/FZD3/TAOK2/WASF1/MYO7A/MAPK8/FZD8/WNT11/VAV1/PSEN2/CDH24/KRT15/PCDHGA10	0.348646992207108
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	37/2138	154/9376	1.05363672809884	CDKN1A/RGS2/PRKAG2/GNAQ/ITPR2/RCAN1/CAMK2G/PRKAB2/MAPK3/RAF1/PPP3R1/ITPR3/PPP3CA/NFATC3/MAP2K1/MAPK1/PPP3CB/PPP1CC/PPP1R12B/KRAS/PRKAA1/ADCY7/PTGS2/CAMKK2/EGFR/CAMK2D/PRKAB1/PIK3R5/PLCB1/ADCY6/MAPK7/CAMK1D/ADCY9/CACNA2D3/FOS/NFATC1/PRKACB	0.364745781950349
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	21/2138	86/9376	1.07085517871517	CREB5/GNAQ/VAMP2/CAMK2G/ATF6B/ATP1B1/GNA11/CREB3L4/ITPR3/CREB3L2/CREB1/ATF2/ADCY7/CAMK2D/PLCB1/ADCY6/PCLO/ADCY9/KCNMB4/STX1A/PRKACB	0.358751037448634
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	21/2138	86/9376	1.07085517871517	ITGA6/TCF7L2/PKP2/DAG1/ITGB4/JUP/ITGB6/SGCE/TCF7/ATP2A2/DSG2/ITGB1/ITGAV/TCF7L1/ITGA3/ITGA2/ITGA5/SNTB1/SNTB2/CACNA2D3/ITGA2B	0.358751037448634
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/2138	69/9376	1.08046257507355	CREB5/CAMK2G/ATF6B/PPP3R1/CREB3L4/CREB3L2/TH/PPP3CA/PPP3CB/PPP1CC/CREB1/ATF2/CAMK2D/SIRT1/FOS/STX1A/PRKACB	0.364580817992496
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/2138	35/9376	1.12767606574903	GMDS/FBP1/PMM1/ENOSF1/PFKFB4/AKR1B1/FPGT/KHK/PFKFB2	0.411269996175173
Cellular Processes	Cell motility	hsa04814	Motor proteins	46/2138	194/9376	1.03983875478576	DYNLT1/TNNI2/TNNT3/DCTN4/DYNC1I2/KIF20B/KIF21A/KIF12/DCTN1/KIF23/DNAL4/MYO1F/KIF2C/DYNC1LI2/KIF11/KIF1C/DYNLL2/MYO1D/MYO5C/KIF22/MYO9B/ACTG2/KIF15/KIF20A/DNAH14/KIF4A/DNAH11/KIF18A/CAPZA1/MYO9A/MYO7B/KIF18B/MYO5B/MYO5A/KIF3C/ACTA1/MYO7A/KIFC3/KLC4/TUBA4A/KIF26B/KIF27/KIF26A/DYNLRB2/ACTC1/KIF24	0.304732079631889
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/2138	48/9376	1.09635173058934	ACAA2/HIBADH/BCAT2/MCEE/IL4I1/HADH/DBT/ABAT/ALDH9A1/BCAT1/BCKDHB/BCKDHA	0.36371906729137
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	19/2138	78/9376	1.06824014775371	CNOT6L/PABPC1/CNOT1/CNOT6/DCP2/BTG3/EXOSC6/PARN/DCP1B/CNOT7/PATL1/CNOT8/CNOT4/CNOT10/DIS3L/ENO3/PAN2/BTG2/PABPC1L	0.328906675607104
NA	NA	hsa04517	IgSF CAM signaling	70/2138	299/9376	1.02668389486627	PTPRF/EPB41L3/ITGB2/IL1RAP/ESAM/PARD6G/NLGN4X/VAV3/CD84/NRP1/MAG/FOXO1/PTPRS/RASA1/CD48/TJP2/ITGAX/MAPK3/PIK3R1/TJP1/JAM2/PDPK1/EPB41L2/PTK2/ICAM1/LCP2/ARPC2/RAPGEF2/CD86/DOK1/PAK2/MAP2K1/ARF6/ITGAM/CSK/MAPK1/DYNLL2/PTPN6/VCL/VAV2/ITGB1/MSN/PIK3CA/GRIP1/PVR/BAIAP2/WASL/LMO7/DOK2/GIT1/RAP1B/SLAMF7/ITGAL/ITGA5/CABLES1/PIK3R2/MBP/NLGN2/CABLES2/TRAF6/RAPGEF6/CRTAM/MAPK8/TUBA4A/PIK3R3/VAV1/CASK/GLDN/PLCG1/PLXNA2	0.254855403815508
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	51/2138	217/9376	1.03067167299643	CREB5/GSTT1/KLF4/RXRA/NOTCH2/BCL6/MAPK3/PIK3R1/ATF6B/XIAP/AHR/SOS1/RAF1/NFKB1/CREB3L4/RPS6KA3/CREB3L2/RXRB/KPNA6/MAP2K1/RB1/RPS6KB1/MAPK1/PIK3CA/CREB1/EPHX2/ATF2/MTOR/KRAS/ADCY7/ARRB2/IKBKE/EGFR/EPHX3/PIK3R2/PPARA/GSTM4/ADCY6/KLF5/ADCY9/MIR29A/PIK3R3/STAT5A/DLL1/PAQR8/FOS/ARRB1/JAK2/PRKACB/KPNA5/VEGFA	0.248441133502179
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/2138	23/9376	1.1440191971367	GLUL/NOS2/GOT2/GLUD1/CAD/GPT	0.375827915858295
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/2138	23/9376	1.1440191971367	POMGNT1/FKTN/POMT2/CHST10/FKRP/POMGNT2	0.375827915858295
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	9/2138	36/9376	1.09635173058934	GALNT6/GALNT7/ST6GALNAC2/B4GALT5/GALNT3/B3GNT3/C1GALT1/GALNT11/GALNT10	0.314787538073353
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	39/2138	166/9376	1.03030644561407	PPIF/CREB5/RGS2/GTF2I/GNAQ/ITPR2/IRS2/MAPK3/ATF6B/ATP1B1/GNA11/RAF1/PPP3R1/CREB3L4/ITPR3/CREB3L2/GNA13/PPP3CA/NFATC3/MAP2K1/MAPK1/ATP2A2/SRF/PPP3CB/PPP1CC/CREB1/PRKCE/ATF2/PRKG1/PDE3B/ADCY7/PIK3R5/PLCB1/ADCY6/MEF2A/ADCY9/ADORA1/KCNMB4/NFATC1	0.214111223317088
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	53/2138	227/9376	1.02390558099092	PPIF/GSTT1/FOXO3/HMOX1/NFKBIA/NDUFA13/NCF2/MAPK3/PIK3R1/PDPK1/AHR/PTK2/MT-ND3/SOS1/SDHD/RAF1/HIF1A/NFKB1/MAP3K5/MT-ND4L/CAT/MAP2K1/MAPK1/PTPN1/PLD1/MAP2K7/NFE2L2/NDUFS1/IKBKG/PIK3CA/SOD1/EPHX2/ABL2/KRAS/COX8A/ARAF/IKBKB/MAP2K4/CHUK/EGFR/EPHX3/MT-ND2/PRKD2/PIK3R2/SLC26A6/MET/GSTM4/NOX4/MAPK8/PIK3R3/UQCR10/FOS/VEGFA	0.198155265481415
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/2138	15/9376	1.16944184596196	HEXA/ST8SIA1/B3GALT4/ST3GAL5	0.35693191356898
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	36/2138	154/9376	1.02516005977185	RFK/NMNAT2/GUSB/MAT2A/PMM1/SHMT1/NME3/BCAT2/UGP2/CPOX/NME6/PPCDC/GSS/COQ7/PANK3/QPRT/MAT2B/DHFR/NADK/CMPK2/CTPS2/LIAS/EARS2/PANK2/PANK1/GPHN/AK5/BCAT1/GCLC/PHOSPHO2/CAD/AK9/PNPO/MTHFD2L/NADSYN1/NMNAT1	0.171095926255759
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/2138	41/9376	1.0696114444774	GLDC/SDS/AGXT/SHMT1/BPGM/PIPOX/SDSL/AMT/CHDH/SRR	0.242770331967964
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/2138	37/9376	1.06672060273557	GLUL/AGXT/IL4I1/GOT2/GLUD1/ABAT/ALDH5A1/CAD/GPT	0.220999267654872
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	24/2138	103/9376	1.0218423896755	CSTF3/SYMPK/PABPN1/PABPC1/SMG1/WDR82/DDX19A/CASC3/PPP2CA/RNPS1/PPP2CB/UPF2/PPP2R5E/TARDBP/RNGTT/PPP1CC/CPSF2/PAPOLG/SMG7/GSPT2/CPSF7/CSTF1/FUS/PABPC1L	0.121140352345794
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	23/2138	99/9376	1.01883191125474	ITGA6/PRKAG2/DAG1/TGFB2/ITGB4/PRKAB2/ITGB6/SGCE/ATP2A2/ITGB1/ITGAV/ITGA3/PRKAA1/ITGA2/ITGA5/SNTB1/SNTB2/TGFB1/PRKAB1/TNF/CACNA2D3/ACTC1/ITGA2B	0.102373704068946
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/2138	38/9376	1.03864900792674	HEXA/PMM1/GNPDA1/UGP2/GALT/AMDHD2/GNE/FPGT/RENBP	0.129742843936622
Human Diseases	Substance dependence	hsa05032	Morphine addiction	21/2138	91/9376	1.01201698208246	PDE10A/GNG12/GRK4/PDE7A/GNG4/PDE3B/ADCY7/ARRB2/PDE4B/GABRE/PDE8A/PDE4C/PDE4A/ADCY6/GNG10/GABBR2/ADCY9/ADORA1/GNGT1/ARRB1/PRKACB	0.0626044716978148
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/2138	43/9376	1.01986207496682	ACAA2/ACOX1/ACADVL/ACSL5/HADH/ALDH9A1/ACSL1/CPT1A/CPT1B/CYP2U1	0.0709460810761698
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/2138	12/9376	1.09635173058934	CD46/NPC1/ASGR1	0.181509616527749
Organismal Systems	Digestive system	hsa04978	Mineral absorption	14/2138	61/9376	1.00648683463939	MT1X/MT1H/MT1G/MT2A/MT1F/HMOX1/MT1M/FTL/ATP1B1/TRPM7/SLC30A1/SLC26A6/ATP7A/CYBRD1	0.0276239967531067
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/2138	39/9376	1.01201698208246	GLDC/MAT2A/SHMT1/MAT2B/DHFR/MTHFR/AMT/MTHFD2L/CHDH	0.0408699622896338
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	20/2138	88/9376	0.996683391444851	SERPINE1/ITGB2/SERPINE2/C1QB/CD59/CD46/SERPINA1/CLU/C1QA/C5AR1/ITGAX/C1QC/C3AR1/ITGAM/SERPING1/PLAU/C2/THBD/VSIG4/VWF	-0.0169884849045359
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	30/2138	133/9376	0.989189531358799	CREB5/GNAQ/ITPR2/CAMK2G/ATF6B/GNG12/CREB3L4/ITPR3/CREB3L2/GNG4/PPP2CA/TH/PPP3CA/PPP2CB/PPP2R5E/CLOCK/PPP3CB/PPP1CC/CREB1/ATF2/ARRB2/CAMK2D/PLCB1/GNG10/MAPK8/GNAL/GNGT1/FOS/ARRB1/PRKACB	-0.0682407929342284
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/2138	26/9376	1.01201698208246	LMBRD1/PLB1/SLC5A6/SLC19A3/SCARB1/TCN2	0.0333469778788977
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/2138	44/9376	0.996683391444851	MAN1A1/FUT8/MAN2A1/HEXA/MGAT4A/MGAT2/ALG12/ALG11/MAN1C1/MAN2A2	-0.0119843197859448
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/2138	17/9376	1.03186045231937	FMO4/ADO/CSAD/FMO5	0.0714565219104964
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/2138	71/9376	0.98826071489743	MAPK3/PIK3R1/IDH1/RAF1/ERBB2/HIF1A/MAP2K1/MAPK1/PIK3CA/FGFR3/MTOR/KRAS/EGFR/PIK3R2/MET/PIK3R3	-0.0539625960877325
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/2138	31/9376	0.990253176016174	ACOX1/ABAT/ALDH9A1/MLYCD/DPYD/ALDH3B1/CSAD	-0.0295416342286972
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	108/2138	480/9376	0.986716557530402	PPIF/GPX3/MAP2K3/GNAQ/ITPR2/WNT7A/NDUFA13/AXIN2/CAMK2G/FZD1/ATXN2L/MAPK3/NOS2/DCTN4/IL1B/ATXN1/GPX8/MT-ND3/BAX/SDHD/RAF1/PPP3R1/ATXN2/GPR37/CYBB/NFKB1/ITPR3/DCTN1/MAP3K5/PSEN1/DNAL4/HIP1/MT-ND4L/CAPN2/SIGMAR1/RAB1A/PPP3CA/RAB5A/CAT/CHRM5/MAP2K1/FZD6/CSNK2A2/FADD/FRAT2/TARDBP/MAPK1/ATP2A2/MAP2K7/PPP3CB/NDUFS1/MCU/SPG11/CASP7/SOD1/PRNP/PSMA6/ATG13/DNAH14/MTOR/MAPT/KRAS/COX8A/ARAF/OPTN/APC/MFN2/FZD7/EIF2AK3/HTT/PINK1/DNAH11/SQSTM1/PTGS2/WNT6/ATG14/C9orf72/UBA7/PSMA8/ATXN1L/MT-ND2/TNFRSF1B/BID/MAP1LC3B/CAMK2D/PIK3C3/FIG4/WNT5B/NOX4/PLCB1/ULK2/FZD3/UBE2L6/FUS/TNF/ATG2B/ULK1/MAPK8/KLC4/FZD8/TUBA4A/WNT11/UQCR10/FRAT1/PLCG1/PSEN2/STX1A/AMBRA1	-0.162373095422125
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/2138	157/9376	0.977638485875841	PRKAG2/RXRA/NDUFA13/IRS2/CEBPA/BCL2L11/PRKAB2/PIK3R1/IL1B/BAX/SDHD/NFKB1/MAP3K5/SREBF1/MLXIP/NDUFS1/PIK3CA/CASP7/MAP3K11/COX8A/EIF2AK3/PRKAA1/IKBKB/PIK3R2/BID/PPARA/TGFB1/PRKAB1/IL6R/LEPR/TNF/MAPK8/PIK3R3/UQCR10/FOS	-0.15356396774007
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/2138	13/9376	1.01201698208246	DCLRE1C/FEN1/POLM	0.0235634988382634
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/2138	27/9376	0.974534871634965	ACOX1/ELOVL4/ELOVL5/SCP2/ELOVL1/ACOT2	-0.0720153989873258
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/2138	32/9376	0.959307764265669	ACOX1/MCEE/DBT/ABAT/MLYCD/BCKDHB/BCKDHA	-0.125314211350195
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	50/2138	226/9376	0.970222770433041	CREB5/ACOX1/VAV3/TIAM1/NFKBIA/EP300/PDE10A/CAMK2G/MAPK3/PIK3R1/CREBBP/ATP1B1/RAF1/GLI3/NFKB1/CREB3L4/CREB3L2/MAP2K1/CRH/RRAS2/MAPK1/ATP2A2/PLD1/VAV2/PPP1CC/PIK3CA/CREB1/SLC9A1/RAC2/PDE3B/ADCY7/RAP1B/PDE4B/PIK3R2/PLCE1/PPARA/CAMK2D/PDE4C/PDE4A/ADCY6/GABBR2/ADCY9/MAPK8/ADORA1/PIK3R3/VAV1/FOS/NFATC1/HCAR1/PRKACB	-0.246268100665564
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	23/2138	105/9376	0.960612944897323	ITGA6/DAG1/TGFB2/ITGB4/ITGB6/SGCE/ATP2A2/ITGB1/ITGAV/ITGA3/ITGA2/ADCY7/ITGA5/SNTB1/SNTB2/TGFB1/ADCY6/TNF/ADCY9/CACNA2D3/ACTC1/ITGA2B/PRKACB	-0.22057945983841
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/2138	37/9376	0.948196091320507	GNAQ/APOL1/IL1B/IL18/ICAM1/PLCB1/TNF/F2RL1	-0.171590564389857
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/2138	42/9376	0.939730054790859	AOC1/AADAT/DHTKD1/IL4I1/CAT/HADH/ALDH9A1/ALDH8A1/ASMT	-0.212751065026556
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	21/2138	97/9376	0.949417993500044	GNAQ/CAMK2G/MAPK3/GNG12/ITPR3/GNG4/MAPK1/RPS6KA5/PER2/CREB1/PRKG1/ADCY7/CAMK2D/PLCB1/ADCY6/GNG10/ADCY9/GNGT1/FOS/PRKACB/CACNA1G	-0.272152001161403
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	12/2138	56/9376	0.939730054790859	GLI3/SPOPL/CUL1/IQCE/CSNK1G3/ARRB2/FBXW11/HHAT/MEGF8/DISP1/ARRB1/PRKACB	-0.24584821150288
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/2138	75/9376	0.935553476769567	SDS/GLUL/MAT2A/SHMT1/BCAT2/IDH1/PYCR2/IDH3B/ACO1/GOT2/MAT2B/CS/SDSL/BCAT1/ENO3/GPT	-0.304540812237359
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/2138	34/9376	0.902877895779453	POLR2K/CRCP/POLR2M/POLR3K/POLR3A/POLR2J3/POLR3F	-0.308331438739036
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/2138	44/9376	0.897015052300366	GTF2I/TAF5L/TAF11/TAF7/TBP/TAF1/TAF4/GTF2E1/TAF2	-0.372128493866136
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/2138	20/9376	0.877081384471469	SOAT1/LIPA/MSMO1/DHCR24	-0.299066487856129
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/2138	10/9376	0.877081384471469	SUOX/TST	-0.211359018025586
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/2138	59/9376	0.891947170648951	GSTT1/GPX3/GPX4/RRM1/GPX8/IDH1/GSS/GSTK1/RRM2B/GCLC/GSTM4/OPLAH	-0.45248511861459
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	9/2138	45/9376	0.877081384471469	ABCG1/ABCD1/ABCA1/ABCC3/ABCB10/ABCC10/ABCA5/ABCA12/ABCA4	-0.449200283248279
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/2138	69/9376	0.889792708884099	CTSB/GNAQ/ITPR2/PPP3R1/ITPR3/PPP3CA/PTGER4/PPP3CB/CREB1/PDE3B/PLCB1/ADCY6/ADORA1/PRKACB	-0.499355934197304
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	50/2138	235/9376	0.933065302629222	CREB5/PRKAG2/MAP2K3/NDUFA13/MGLL/ARID1A/TSC1/PRKAB2/SMARCE1/SMARCD2/COX14/MT-ND3/SOS1/SDHD/CREB3L4/RPS6KA3/CREB3L2/MAP3K5/ACSL5/MT-ND4L/RPS6KB1/COX19/MLST8/FRS2/NDUFS1/CREB1/KDM3B/RHEB/ATF2/MTOR/SMARCD1/KRAS/COX8A/PRKG1/PRKAA1/ADCY7/PRDM16/ACSL1/MT-ND2/KDM3A/PRKAB1/ADCY6/CPT1A/RPTOR/ADCY9/UQCR10/CPT1B/SLC25A20/PRKACB/SLC25A29	-0.564766047618627
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	24/2138	116/9376	0.907325570142899	SLC17A8/GNAQ/ITPR2/GLUL/HOMER3/MAPK3/GNG12/SLC1A3/PPP3R1/SLC38A1/ITPR3/GNG4/PPP3CA/HOMER1/MAPK1/PLD1/PPP3CB/ADCY7/PLCB1/ADCY6/GNG10/ADCY9/GNGT1/PRKACB	-0.545837819551371
NA	NA	hsa04981	Folate transport and metabolism	6/2138	31/9376	0.848788436585292	SHMT1/ABCC3/DHFR/SLCO2B1/MTHFR/FOLR1	-0.458306901300315
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/2138	16/9376	0.822263797942002	IL4I1/GOT2/ALDH3B1	-0.386703552644051
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	54/2138	254/9376	0.932330605540538	PPIF/P2RX4/CXCR4/ERBB3/GNAQ/ITPR2/STIM2/PHKA2/CAMK2G/NOS2/PLCD3/GNA11/PPP3R1/ERBB2/ITPR3/PPP3CA/CHRM5/NFATC3/PHKB/MCOLN1/ATP2A2/PPP3CB/MCU/ASPH/PTAFR/FGFR3/ADCY7/EGFR/PDGFA/CYSLTR2/PLCE1/GNA15/STIM1/MET/CAMK2D/HRH1/TPCN1/P2RX7/ITPKC/PDGFB/PLCB1/CAMK1D/ITPKA/ADCY9/ORAI3/ORAI2/GNAL/PLCG1/SPHK2/NFATC1/PRKACB/CACNA1G/MST1R/VEGFA	-0.594215962069273
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	13/2138	65/9376	0.877081384471469	MGLL/LPL/DGKH/AGPAT1/LPIN2/ALDH9A1/LIPG/AKR1B1/MBOAT1/GK/LPIN1/GPAM/DGKA	-0.540451061606383
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	18/2138	89/9376	0.886936231488002	GABARAP/GLUL/GABARAPL2/GNG12/SLC38A1/GNG4/GABARAPL1/ABAT/ADCY7/GPHN/GABRE/ADCY6/GNG10/GABBR2/ADCY9/GNGT1/PRKACB/SLC12A5	-0.58245306715436
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/2138	22/9376	0.797346713155881	AOC1/HNMT/ALDH9A1/ALDH3B1	-0.517185700675845
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	36/2138	174/9376	0.907325570142899	MAN1A1/MBTPS1/GANAB/WFS1/ATF6B/DERL3/BAX/EDEM3/UGGT2/MAP3K5/RNF5/CAPN2/SEC31A/SEL1L/OS9/CUL1/DNAJC1/MAP2K7/SEC24D/NFE2L2/HSPA6/SEC24C/SEC63/EIF2AK3/RNF185/DNAJB2/UBE2D4/HSPA4L/RBX1/UBQLN4/RRBP1/FBXO6/MAPK8/MAN1C1/HSPA1B/FBXO2	-0.670615569043105
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/2138	76/9376	0.865540839938949	GNAQ/ITPR2/CAMK2G/ATP1B1/SLC4A2/ITPR3/SLC9A1/ADCY7/CAMK2D/PLCB1/ADCY6/KCNQ1/ADCY9/KCNJ15/PRKACB	-0.639640442564232
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/2138	52/9376	0.84334748506872	IGF1R/ALOX5/SCARB1/ADCY7/PTGS2/ACOT2/ADCY6/ADCY9/HSD17B1/PRKACB	-0.615627639908221
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/2138	17/9376	0.773895339239531	DAG1/LAMP2/TFRC	-0.507106819568617
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/2138	53/9376	0.82743526836931	CLTB/GNAQ/AP2B1/AP2A2/ATP1B1/DNM2/PLCB1/ADCY6/ADCY9/PRKACB	-0.684687394488656
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	40/2138	195/9376	0.899570650739968	PPIF/ITGB2/FCGR3A/NCF2/C5AR1/FPR3/SYK/MAPK3/PIK3R1/FCGR1A/RAF1/AQP9/CYBB/NFKB1/MAP3K7/MAP2K1/FCGR2A/ITGAM/FPR1/MAPK1/HDAC6/PIK3CA/MTOR/RAC2/CASP1/TLR4/ITGAL/ATG7/PIK3R2/CLCN5/SELPLG/PLCB1/HDAC4/PIK3R3/FCGR3B/PADI4/PLCG1/ITGA2B/ELANE/VWF	-0.770217106197763
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/2138	23/9376	0.762679464757799	PRCP/MME/CTSA/LNPEP	-0.619304120031954
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	23/2138	116/9376	0.869520338053611	GLDC/FBP1/ACOX1/SDS/AGXT/SHMT1/IDH1/SDHD/MCEE/H6PD/ADPGK/CAT/IDH3B/ACO1/GOT2/OGDH/GLUD1/ME2/CS/SDSL/AMT/ENO3/GPT	-0.768504691989313
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/2138	49/9376	0.805482904106451	CREB5/ATF6B/NFKB1/CREB3L4/CREB3L2/TH/CREB1/ATF2/PRKACB	-0.741933580242388
NA	NA	hsa04382	Cornified envelope formation	44/2138	217/9376	0.889206933565544	CLDN19/COL17A1/ITGA6/COL4A1/KRT14/COL4A2/PKP2/ELOVL4/LAMA5/ITGB4/KRT7/DST/ST14/JUP/CLDN23/TJP1/UGCG/PCSK6/LAMC2/PPP2CA/S100A8/PLEC/PPP2CB/KRT16/PPP2R5E/KDSR/ELOVL1/DSG2/KAZN/EPHX2/S100A4/SPTLC2/ABCA12/CLDN14/KRT9/SLC27A1/EPHX3/GBA2/TMEM79/S100A5/LAMB3/S100A9/SPRR2G/KRT15	-0.897425941270487
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	76/2138	368/9376	0.905681864399886	GPX3/MAP2K3/NDUFA13/HNRNPA1/ATXN2L/NOS2/DCTN4/NUP153/NUP62/GPX8/MT-ND3/BAX/SDHD/PPP3R1/NUP214/ATXN2/ITPR3/DCTN1/MAP3K5/DNAL4/ANXA11/MT-ND4L/NUP160/SIGMAR1/RAB1A/PPP3CA/RAB5A/CAT/NUP50/NUP133/NUP35/TARDBP/HDAC6/SETX/PPP3CB/NDUFS1/MCU/SPG11/MATR3/POM121/SOD1/NUP93/NUP210/PSMA6/ATG13/DNAH14/MTOR/RANBP2/COX8A/NUP205/OPTN/CASP1/EIF2AK3/PINK1/DNAH11/SQSTM1/ATG14/C9orf72/PSMA8/MT-ND2/TNFRSF1B/BID/MAP1LC3B/PIK3C3/CHCHD10/FIG4/UBQLN4/ULK2/FUS/TNF/ATG2B/ULK1/KLC4/TUBA4A/UQCR10/AMBRA1	-1.00319446480861
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/2138	37/9376	0.71114706849038	GMDS/PMM1/UGP2/GALT/GNE/FPGT	-0.956770228479315
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/2138	63/9376	0.76570597057033	PTGES/HPGD/GPX4/PLB1/TBXAS1/ALOX5/EPHX2/PTGS2/LTA4H/PLA2G6/CYP2U1	-1.0140675696697
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/2138	32/9376	0.685219831618335	GALM/GAA/UGP2/GALT/AKR1B1	-0.969384646421623
NA	NA	hsa04081	Hormone signaling	43/2138	219/9376	0.861061633156921	CSH2/IGF2/CSH1/HAMP/GNAQ/IRS2/THRB/SMAD4/PIK3R1/GNG12/GNA11/IGF1R/GNG4/SMAD1/GNA13/CSHL1/CRH/GH2/PIK3CA/ITGAV/VIPR1/SLC16A10/PRKG1/STK11/ADCY7/OPRK1/SMAD5/ACVR1/PIK3R2/GNA15/DIO2/GUCA2A/PLCB1/ADCY6/GNG10/LEPR/MC1R/ADCY9/PIK3R3/STAT5A/GNGT1/JAK2/PRKACB	-1.13070116389182
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/2138	27/9376	0.64968991442331	HADH/ABAT/ALDH5A1/BDH1	-0.990677141715442
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/2138	134/9376	0.818172933275624	GNAQ/ITPR2/MAPK3/GNA11/RAF1/ITPR3/GNA13/MAP2K1/MAPK1/PPP1CC/ACTG2/PRKCE/ARHGEF12/PPP1R12B/PRKG1/ARAF/ADCY7/PRKCH/PLCB1/ADCY6/ADCY9/KCNMB4/PLA2G6/ARHGEF11/PRKACB	-1.15214767822576
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/2138	149/9376	0.824103314268494	SLC17A8/GNAQ/ITPR2/NDUFA13/MGLL/MAPK3/GNG12/MT-ND3/FAAH/ITPR3/GNG4/MT-ND4L/MAPK1/NDUFS1/DAGLB/NAPEPLD/ADCY7/PTGS2/MT-ND2/GABRE/PLCB1/ADCY6/GNG10/ADCY9/MAPK8/GNGT1/ABHD6/PRKACB	-1.17625296088761
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/2138	28/9376	0.626486703193906	ST8SIA1/ST3GAL6/B3GNT3/A4GALT	-1.07573656308479
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/2138	28/9376	0.626486703193906	TH/DHFR/AKR1B1/GPHN	-1.07573656308479
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/2138	50/9376	0.701665107577175	AOC1/AMD1/OAT/NOS2/PYCR2/GOT2/ALDH9A1/SAT1	-1.14953327226249
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/2138	23/9376	0.572009598568349	ATP1B1/GLUD1/PCK2	-1.11687013797708
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	18/2138	103/9376	0.766381792256623	COL17A1/PRCP/COL21A1/COL4A1/COL4A2/MME/COL12A1/ATP1B1/SLC7A7/DPP4/SLC7A9/SLC16A10/COL9A3/KCNE3/KCNK5/KCNQ1/COL11A1/SLC7A8	-1.2956728829068
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/2138	17/9376	0.515930226159687	TXNRD3/SEPHS2	-1.08567016104773
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/2138	17/9376	0.515930226159687	GLUL/GLUD1	-1.08567016104773
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/2138	154/9376	0.797346713155881	CREB5/GNAQ/CAMK2G/MAPK3/ATF6B/ATP1B1/CREB3L4/CREB3L2/PPP2CA/PPP2CB/PPP2R5E/MAPK1/ATP2A2/RPS6KA5/PPP1CC/CREB1/SLC9A1/ATF2/ADCY7/CAMK2D/PIK3R5/PLCB1/ADCY6/KCNQ1/ADCY9/CACNA2D3/ACTC1/PRKACB	-1.37810291930097
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/2138	36/9376	0.609084294771853	GUSB/DCXR/UGP2/AKR1B1/FGGY	-1.27714771380138
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/2138	36/9376	0.609084294771853	GAA/UGP2/AGL/PYGB/PGM2L1	-1.27714771380138
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	38/2138	205/9376	0.812904697802825	PPIF/CTSD/CD36/MPC1/TGFB2/TGFBR1/NDUFA13/NCF2/CAMK2G/MMP9/SP1/PIK3R1/MT-ND3/SDHD/CYBB/NFKB1/MT-ND4L/SMAD2/ATP2A2/PPP1CC/NDUFS1/PIK3CA/MTOR/COX8A/TBC1D4/RAC2/PDK4/MT-ND2/PIK3R2/PPARA/CAMK2D/TGFB1/PLCB1/SMAD3/MAPK8/PIK3R3/UQCR10/CPT1B	-1.47201306936084
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/2138	37/9376	0.592622557075317	IL4I1/TH/GOT2/FAHD1/ALDH3B1	-1.34936006052404
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/2138	43/9376	0.611917244980094	CD36/AGPAT1/ABCA1/GOT2/SCARB1/SLC27A1	-1.38620716354632
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	52/2138	275/9376	0.829240581682116	PPIF/CREB5/LAMC1/C1QB/ITPR2/NDUFA13/C1QA/NCF2/MAPK3/PIK3R1/ATF6B/C1QC/IL1B/MT-ND3/BAX/SDHD/PPP3R1/CYBB/CREB3L4/ITPR3/CREB3L2/MT-ND4L/PPP3CA/CSNK2A2/MAPK1/PPP3CB/HSPA6/NDUFS1/MCU/PIK3CA/SOD1/CREB1/PRNP/PSMA6/ATF2/COX8A/RAC2/EIF2AK3/CCL5/PSMA8/MT-ND2/PIK3R2/NOTCH1/TNF/MAPK8/KLC4/EGR1/TUBA4A/PIK3R3/UQCR10/HSPA1B/PRKACB	-1.56202023544766
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/2138	82/9376	0.695247438910311	GSTT1/UPP1/GUSB/RRM1/NME3/NME6/TK2/CES2/RRM2B/DPYD/GSTM4/DUT/CES1	-1.50637519408431
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/2138	12/9376	0.365450576863112	COQ7	-1.19537886612935
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/2138	26/9376	0.506008491041232	ACOX1/PLB1/PLA2G6	-1.37082037807565
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/2138	115/9376	0.724545491519909	GNAQ/ITPR2/MAPK3/GNG12/RAF1/ITPR3/GNG4/MAP2K1/MAPK1/SLC6A4/ALOX5/KRAS/ARAF/PTGS2/DUSP1/PLCB1/GNG10/GNGT1/PRKACB	-1.6152883558306
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/2138	46/9376	0.572009598568349	HMOX1/FTL/GUSB/BLVRA/CPOX/EARS2	-1.58143855437848
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/2138	14/9376	0.313243351596953	FUT8	-1.39753525083411
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/2138	48/9376	0.548175865294668	PIK3R1/ATP1B1/PIK3CA/PIK3R2/PLCB1/PIK3R3	-1.70559523788089
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/2138	93/9376	0.660168784010783	LYZ/GNAQ/VAMP2/ITPR2/ATP1B1/SLC4A2/ITPR3/SLC9A1/PRKG1/ADCY7/PLCB1/ADCY6/ADCY9/PRKACB	-1.78994945645126
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/2138	15/9376	0.292360461490489	AK5	-1.49065381791212
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/2138	23/9376	0.381339732378899	ICMT/IDI1	-1.6144361559222
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	56/2138	308/9376	0.797346713155881	PPIF/CREB5/GPX3/CLTB/GNAQ/NDUFA13/EP300/AP2B1/SP1/POLR2K/DCTN4/CREBBP/SLC1A3/AP2A2/GPX8/MT-ND3/BAX/SDHD/CREB3L4/CREB3L2/DCTN1/MAP3K5/DNAL4/HIP1/TBP/MT-ND4L/MAP2K7/BBC3/NDUFS1/TAF4/SOD1/CREB1/PSMA6/ATG13/DNAH14/MTOR/SIN3A/COX8A/HTT/DNAH11/ATG14/PSMA8/MT-ND2/PIK3C3/NRF1/POLR2J3/PLCB1/ULK2/ATG2B/ULK1/MAPK8/KLC4/TUBA4A/UQCR10/STX1A/AMBRA1	-1.96541132300109
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/2138	31/9376	0.424394218292646	FBP1/H6PD/DERA	-1.74460270251517
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/2138	46/9376	0.476674665473624	PSMB8/PSMB10/PSMA6/PSMA8/PSMB9	-1.93370425536329
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	22/2138	143/9376	0.674677988054976	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMA/FCGR3A/HLA-DMB/C1QB/C1QA/HLA-DQA2/HLA-DRB5/C1QC/FCGR1A/CD86/FCGR2A/CD40/C2/TNF/FCGR3B/ELANE	-2.13054273451698
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/2138	47/9376	0.466532651314611	HAGH/ALDH9A1/ME2/PCK2/GLO1	-1.99259678333525
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/2138	90/9376	0.584720922980979	RXRA/ATP1B1/AQP9/SLC4A2/ABCC3/SLC9A1/NCEH1/SCARB1/ADCY7/ADCY6/ADCY9/PRKACB	-2.15142972608358
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/2138	67/9376	0.523630677296399	FBP1/GALM/BPGM/ADPGK/ALDH9A1/PCK2/ENO3/ALDH3B1	-2.1267178264501
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/2138	102/9376	0.601918597186302	RAB27B/GNAQ/ITPR2/ATP1B1/SLC4A2/ITPR3/ATP2A2/SLC9A1/ADCY7/RAP1B/PLCB1/ADCY6/KCNQ1/ADCY9	-2.1969421866739
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/2138	29/9376	0.3024418567143	SLC24A1/GNGT1	-2.0446712473723
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2138	30/9376	0.292360461490489	PLB1/PLA2G6	-2.10979388316913
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/2138	31/9376	0.282929478861764	GUSB/ALDH9A1	-2.17336796958679
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/2138	31/9376	0.282929478861764	SEC63/IMMP2L	-2.17336796958679
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	19/2138	138/9376	0.603787909599924	NDUFA13/ATP6V0D1/ATP6V1G1/ATP6V1E1/MT-ND3/ATP6V1A/SDHD/ATP6V1H/MT-ND4L/LHPP/ATP6V1D/ATP6V1C1/ATP6AP1/ATP6V0E1/NDUFS1/COX8A/MT-ND2/ATP6V0A1/UQCR10	-2.54834654963162
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2138	26/9376	0.168669497013744	MNX1	-2.30693194871202
Human Diseases	Substance dependence	hsa05034	Alcoholism	27/2138	191/9376	0.619926633003394	CREB5/SLC29A1/MAPK3/ATF6B/GNG12/SLC29A3/SOS1/RAF1/CREB3L4/CREB3L2/GNG4/TH/MAP2K1/CRH/MAPK1/HDAC6/PPP1CC/CREB1/ATF2/KRAS/PKIA/ARAF/CAMKK2/GNG10/HDAC4/GNGT1/PRKACB	-2.88419580449865
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/2138	87/9376	0.453662785071449	ATP1B1/ATP2A2/ASPH/SLC9A1/COX8A/SLC9A6/UQCR10/CACNA2D3/ACTC1	-2.78237798586408
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/2138	70/9376	0.375892021916344	GSTT1/GSTK1/SULT1A1/PTGS2/SULT1A3/GSTM4	-2.84844231917696
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	40/2138	268/9376	0.654538346620499	SLC39A8/PPIF/ITPR2/NDUFA13/SLC39A11/CAMK2G/MT-ND3/BAX/SDHD/GPR37/ITPR3/MAP3K5/SLC39A13/SLC39A9/MT-ND4L/TH/NFE2L2/NDUFS1/MCU/SOD1/PSMA6/SLC39A7/MAPT/COX8A/MFN2/EIF2AK3/PINK1/DUSP1/UBA7/PSMA8/MT-ND2/CAMK2D/UBE2L6/MAPK8/KLC4/TUBA4A/GNAL/UQCR10/PLCG1/PRKACB	-3.11842951684643
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/2138	41/9376	0.21392228889548	SLC17A8/GABRE	-2.74145075296371
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/2138	73/9376	0.360444404577316	GSTT1/GSTK1/FMO4/GSTM4/ALDH3B1/FMO5	-2.9813188205952
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/2138	66/9376	0.332227797148284	HSD17B11/SRD5A1/HSD17B8/DHRS11/HSD17B1	-2.95873223537109
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/2138	68/9376	0.322456391349805	RDH10/DHRS4L2/DHRS4/ALDH1A1/CYP26A1	-3.04750004834932
NA	NA	hsa04082	Neuroactive ligand signaling	25/2138	199/9376	0.550930517884088	P2RX4/SLC17A8/GNAQ/SLC6A2/GNG12/SLC1A3/GNA11/TAC3/GNG4/CHRM5/SLC6A4/ADCY7/OPRK1/GABRE/HRH1/PLCB1/P2RY11/ADCY6/GNG10/GABBR2/ADCY9/ADORA1/GNAL/GNGT1/PRKACB	-3.4799252388908
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/2138	86/9376	0.305958622490047	ITPR3/PLCB1/ADCY6/KCNK5/GABBR2/PRKACB	-3.51404186297936
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/2138	79/9376	0.222045920119359	GSTT1/GSTK1/GSTM4/ALDH3B1	-3.77377751179924
Genetic Information Processing	Translation	hsa03010	Ribosome	25/2138	222/9376	0.493852130896097	RPS4Y1/RPL26/RPS10/RPL27A/RPS8/RPL10A/RPS15A/RPS11/RPS27L/RPS21/RPS12/RPL17/RPL36A/RPL9/RPL13A/RPL23/RPS20/RPL7/RPL31/RPS25/MRPL1/RPS17/MRPL53/RPL41/MRPL38	-4.14790351099626
Genetic Information Processing	Transcription	hsa03040	Spliceosome	26/2138	243/9376	0.469220493750168	HNRNPA1/SF1/SRSF2/CASC3/SRSF1/PPIL1/PHF5A/PRPF6/SNRNP27/DHX15/DHX38/WBP11/CRNKL1/PRPF18/RBMXL1/HSPA6/AQR/CDC40/ZMAT2/CDC5L/DHX8/PCBP1/U2AF1L4/PRPF40B/FUS/HSPA1B	-4.55607383260507
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	10/2138	183/9376	0.239639722533188	REXO2/TCOF1/SBDS/FCF1/CSNK2A2/UTP14C/MDN1/WDR36/SNORD3A/RPP25	-5.64542360149625
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	32/2138	370/9376	0.379278436528203	CSH2/CSH1/P2RX4/KISS1/NR3C1/C5AR1/FPR3/THRB/PGRMC1/TAC3/C3AR1/CHRM5/CSHL1/PTGER4/CRH/FPR1/GH2/PTAFR/VIPR1/NPFFR2/OPRK1/CYSLTR2/GABRE/HRH1/P2RX7/P2RY11/NPB/LEPR/GABBR2/MC1R/ADORA1/F2RL1	-6.62082216232607
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	11/2138	449/9376	0.107437586071115	RGS2/NCALD/CAMK2G/ANO2/PRKG1/ARRB2/CAMK2D/OR5AC2/GNAL/ARRB1/PRKACB	-10.5339001399414