category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	122/1193	250/9376	3.83527912824811	ACP5/CTSD/CTSS/PSAP/ASAH1/LIPA/DNASE2/CTSC/CTSZ/HEXB/LAPTM5/NPC2/ATP6V1F/CD68/LAMP2/CTSH/HEXA/FUCA1/ATP6V0D1/BLOC1S2/CTSB/AP1S2/SLC11A1/RRAGD/CTSA/LITAF/ACP2/PPT1/ATP6V1B2/GUSB/GM2A/MANBA/SLC15A3/GNPTAB/GAA/GNPTG/VAMP8/ATP6V0B/SCARB2/ATP6V0E1/OSBPL1A/LGMN/GNS/ATP6AP1/TPP1/SLC29A3/DMXL2/GALC/ARL8A/GGA2/GLA/TCIRG1/GGA1/IGF2R/CTBS/ARL8B/MITF/GLB1/NAGLU/OSTM1/NAGPA/LAMP1/ATP6V1D/CTSL/SNAP29/GPR155/MCOLN1/LAMTOR2/ROGDI/LAMTOR4/ATP6V1A/CLCN7/IDS/SLC17A5/ATP6V1G1/TLR8/TFEB/PLA2G15/M6PR/VPS41/ARSA/SNAPIN/CD63/LAPTM4A/LAMTOR1/DTNBP1/VPS29/SUMF1/RRAGC/ATP6V1H/AP3S1/FIG4/SPG11/RAB7A/CTSO/AP2A1/CTSF/TLR7/VPS26B/AP2S1/SGSH/VAMP7/AGA/GALNS/AP2M1/SLC36A4/SLC36A1/SLC15A4/SLC29A1/CTSK/AP5M1/ARSB/STX17/ATP6V0E2/MAN2B1/VPS18/VPS39/NPC1/PLEKHM1/OSBPL2/ARSG/ZFYVE26	17.3490291778629
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	60/1193	155/9376	3.04226266122272	HLA-B/CTSS/HLA-A/OLR1/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/MSR1/ATP6V1F/ITGB2/LAMP2/NCF2/FCGR3A/HLA-DPB1/CYBA/ATP6V0D1/HLA-DPA1/CD36/HLA-DOA/HLA-DQA1/ATP6V1B2/ATP6V0B/ATP6V0E1/ATP6AP1/TAP1/TCIRG1/HLA-DQB1/RILP/FCGR1A/CLEC7A/LAMP1/ATP6V1D/CTSL/VAMP3/MARCO/STX12/HLA-DRB1/ATP6V1A/ATP6V1G1/NCF1/M6PR/DYNC1LI1/MRC2/RAB5C/SCARB1/TLR4/STX7/ATP6V1H/EEA1/RAB7A/TFRC/STX18/RAB5B/PIK3C3/ATP6V0E2/THBS3	9.78899303982614
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	63/1193	181/9376	2.73551518295027	CTSD/CTSS/HLA-DQA2/HLA-DMA/HLA-DMB/LSP1/HLA-DRA/IL18/ITGB2/LAMP2/FCGR3A/HLA-DPB1/STAT1/ATP6V0D1/CD74/HLA-DPA1/HLA-DOA/ITGAX/BAX/HLA-DQA1/IL10RB/ATP6V0B/ATP6AP1/RIPK2/IFNGR1/TCIRG1/HLA-DQB1/TRADD/FCGR1A/CLEC7A/IL10RA/LAMP1/JAK1/HLA-DRB1/IFNGR2/FCER1G/CYCS/BCL10/CIITA/NFKB1/MRC2/RAB5C/CLEC4E/MAPK14/TLR4/ATP6V1H/EEA1/RHOA/RAB7A/CARD9/CREBBP/IRAK4/RAB5B/CAMP/CASP3/IL10/MYD88/CASP8/VDR/PIK3C3/SPHK1/RFX5/CEBPB	9.00205003494546
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	68/1193	205/9376	2.60694702839736	B2M/HLA-B/VIM/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/CD44/HLA-DPB1/STAT1/HLA-DPA1/HLA-DOA/BAX/HLA-DQA1/TAPBP/OAS1/CD58/TAP1/CIR1/BTK/TAPBPL/HLA-DQB1/TRADD/RELB/NFKBIA/STAT2/JAK1/HLA-DRB1/ITGAL/IFNAR1/CYCS/OAS2/NFKB1/MAPK14/PIK3R1/CD40/SAP30/IFNAR2/NFKBIE/GADD45B/PSMC2/TRAF3/IRF7/GADD45G/CDKN1A/DDB2/IRAK4/SAP30L/CDKN1B/NFKB2/CASP3/TBK1/MYD88/BCL2L11/CASP8/RIPK1/BAK1/E2F3/MAP3K7/TNFAIP3/PLCG2/IKBKG/PIK3CA/FAS	8.88218325352131
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	60/1193	180/9376	2.61972618049735	B2M/HLA-B/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/PILRA/HLA-DPB1/STAT1/CD74/HLA-DPA1/HLA-DOA/TNFRSF14/BAX/HLA-DQA1/TAPBP/OAS1/TAP1/TAPBPL/IFNGR1/HLA-DQB1/TRADD/PPP1CC/NFKBIA/IFIH1/STAT2/EIF4EBP1/JAK1/BIRC3/HLA-DRB1/IFNGR2/IFNAR1/CYCS/OAS2/NFKB1/PIK3R1/IFNAR2/BST2/TRAF3/IRF7/CARD9/CCL5/SOCS3/IRAK4/CASP3/TBK1/MYD88/PML/CASP8/BCL2L1/BAK1/MAP3K7/IKBKG/PIK3CA/FAS/POU2F1	8.37776082623421
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	57/1193	169/9376	2.65072885718962	CTSD/LAMP2/CTSB/RRAGD/GABARAPL1/GABARAP/RRAS/VAMP8/SQSTM1/ATG3/MRAS/IGBP1/TAX1BP1/GABARAPL2/LAMP1/CTSL/CALCOCO2/SNAP29/DAPK1/PRKCD/RB1CC1/CFLAR/ATG7/HIF1A/ITPR1/RAB8A/C9orf72/NRBF2/VPS41/ATG16L2/PIK3R1/WIPI1/STX7/DDIT4/RRAGC/RAB7A/ATG4C/ERN1/WDR45/BECN1/NBR1/WDR41/TBK1/PRKACA/BCL2L1/ATG14/MAP1LC3A/MAP3K7/PIK3C3/MTMR3/STX17/VPS18/VPS39/PIK3CA/PLEKHM1/OPTN/PRKAA1	8.268174020168
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	60/1193	187/9376	2.52166156411509	TXNIP/IL18/CXCL2/CYBA/STAT1/GPSM3/CTSB/CARD16/GABARAPL1/GABARAP/PYCARD/CXCL3/CASP4/RIPK2/GBP2/CASP1/OAS1/GABARAPL2/PKN1/GBP4/IFI16/NFKBIA/GBP5/GBP3/STAT2/JAK1/BIRC3/PRKCD/P2RX7/IFNAR1/ITPR1/OAS2/NFKB1/MAPK14/TLR4/TRPV2/IFNAR2/TRAF3/RHOA/IRF7/PKN2/CARD9/CCL5/PSTPIP1/IRAK4/CARD6/CAMP/TBK1/NAMPT/MYD88/CASP8/RIPK1/BCL2L1/MAP1LC3A/MAP3K7/NLRC4/TNFAIP3/IKBKG/AIM2/MCU	8.02517169649941
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	37/1193	95/9376	3.06094322142321	ACP5/HLA-DQA2/HLA-DMA/HLA-DMB/TNFSF13B/HLA-DRA/IL18/ATP6V1F/ITGB2/CXCL2/HLA-DPB1/ATP6V0D1/HLA-DPA1/HLA-DOA/HLA-DQA1/ATP6V1B2/CD86/ATP6V0B/CXCL3/ATP6V0E1/ATP6AP1/CCL20/TCIRG1/HLA-DQB1/ATP6V1D/CTSL/HLA-DRB1/ITGAL/ATP6V1A/ATP6V1G1/TLR4/ATP6V1H/CCL5/VEGFA/IL15/CTSK/ATP6V0E2	7.70868018116396
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	40/1193	112/9376	2.8068494791043	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/LY96/HLA-DPB1/STAT1/HLA-DPA1/HLA-DOA/ALOX5/HLA-DQA1/IL10RB/GNAI2/IFNGR1/HLA-DQB1/PPIF/NFKBIA/IL10RA/JAK1/BIRC3/HLA-DRB1/IFNGR2/ITGA6/CYCS/CIITA/NFKB1/MAPK14/TLR4/CD40/PIK3R5/IRAK4/HSPA6/CASP3/IL10/MYD88/CASP8/BCL2L1/MAP3K7/SOCS1/IKBKG	7.34482237566468
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	67/1193	248/9376	2.12324581564503	IL18/STX10/LY96/BAX/RAB9A/S100A10/RRAS/PYCARD/RALA/CASP4/RHOG/RIPK2/CASP1/PLEKHM2/ARL8A/PKN1/TRADD/RILP/DCTN2/ARL8B/NFKBIA/TNFSF10/GCC2/BIRC3/ACBD3/PTPRC/CYCS/TLR5/CYTH1/ARPC1B/M6PR/DYNC1LI1/NFKB1/VPS41/RAB5C/MAPK14/ARPC3/TLR4/ARPC4/DCTN3/ABI1/RHOA/BRK1/AHNAK/RAB7A/FLNA/ACTR1A/IRAK4/RAB5B/CASP3/MYD88/CASP8/RIPK1/BAK1/MAP3K7/ARF1/PIK3C3/NLRC4/ARPC5/DCTN1/IKBKG/VPS18/VPS39/PIK3CA/CASP7/PLEKHM1/ANXA2	6.84482609482247
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	52/1193	173/9376	2.36229644021726	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/IL18/HLA-DPB1/STAT1/HLA-DPA1/HLA-DOA/BAX/HLA-DQA1/PYCARD/CASP1/OAS1/IFNGR1/HLA-DQB1/SLC25A5/TRADD/NFKBIA/TNFSF10/IFIH1/STAT2/CALCOCO2/JAK1/HLA-DRB1/IFNGR2/IFNAR1/MX1/CYCS/OAS2/RAB11B/CIITA/NFKB1/TLR4/PIK3R1/IFNAR2/TRAF3/IRF7/CREBBP/CCL5/TLR7/SOCS3/IRAK4/CASP3/TBK1/MYD88/PML/CASP8/BAK1/IKBKG/PIK3CA/FAS	6.90525222969468
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	43/1193	142/9376	2.37989209355041	ACP5/TREM2/TYROBP/NCF2/FCGR3A/CYBA/STAT1/OSCAR/SPI1/LILRB4/SQSTM1/BTK/IFNGR1/TGFBR2/FCGR1A/RELB/NFKBIA/MITF/FOSL2/STAT2/JAK1/IFNGR2/IFNAR1/ITPR1/NCF1/NFKB1/MAPK14/GRB2/PIK3R1/JUNB/SIRPB1/IFNAR2/SOCS3/LILRB3/NFKB2/LILRA2/MAP3K7/CTSK/PLCG2/SOCS1/IKBKG/TEC1/PIK3CA	6.32621500301638
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	30/1193	82/9376	2.87530922249709	B2M/HLA-B/CTSS/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/HLA-DPB1/CD74/CTSB/HLA-DPA1/HLA-DOA/IFI30/HLA-DQA1/TAPBP/LGMN/TAP1/TAPBPL/HLA-DQB1/CTSL/HLA-DRB1/CIITA/PSME2/CD4/HSPA6/RFX5	6.51220503878287
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	63/1193	250/9376	1.98051299245599	HLA-B/HLA-A/HLA-C/HLA-F/CXCR4/HLA-E/CHMP1B/SMAP1/ARRB2/TGFBR2/IGF2R/ACAP2/RAB11FIP1/PDCD6IP/SMURF2/RAB4A/RABEP1/SNX1/STAM/CYTH1/CHMP3/RAB11B/RAB8A/ZFYVE16/ARPC1B/IL2RG/CHMP5/RAB5C/ARF5/ARPC3/ARPC4/SPG21/VPS29/ARAP1/WIPF3/CHMP4B/EEA1/RHOA/RAB7A/TSG101/SMAP2/AGAP3/AP2A1/VPS26B/TFRC/PLD2/AP2S1/RAB5B/PIP5K1C/AP2M1/PLD1/HSPA6/PML/SNX4/GRK6/ARF1/RNF41/ARPC5/VPS37B/IQSEC2/VPS37C/VTA1/VPS45	5.99974385093561
Human Diseases	Immune disease	hsa05330	Allograft rejection	19/1193	39/9376	3.82883057149612	HLA-B/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DQA1/CD86/HLA-DQB1/HLA-DRB1/CD40/IL10/FAS	6.75904200422924
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	28/1193	78/9376	2.82124357899714	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/ITGB2/NCF2/FCGR3A/HLA-DPB1/CYBA/STAT1/HLA-DPA1/HLA-DOA/HLA-DQA1/IFNGR1/HLA-DQB1/FCGR1A/NFKBIA/JAK1/HLA-DRB1/IFNGR2/NCF1/NFKB1/MAPK14/TLR4/IRAK4/IL10/MYD88/MAP3K7	6.16694604104394
Human Diseases	Infectious disease: viral	hsa05162	Measles	40/1193	136/9376	2.31152310043883	STAT1/BAX/RAB9A/OAS1/CD46/STAT5A/TRADD/NFKBIA/IFIH1/STAT2/JAK1/IFNAR1/MX1/CYCS/OAS2/IL2RG/NFKB1/CSNK2A2/TLR4/PIK3R1/IFNAR2/TRAF3/IRF7/CSNK2B/TLR7/CSNK2A1/IRAK4/CDKN1B/HSPA6/CASP3/TBK1/MYD88/CASP8/BCL2L1/BAK1/MAP3K7/TNFAIP3/IKBKG/PIK3CA/FAS	5.88246019948893
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	33/1193	105/9376	2.47002754161178	GABARAPL1/GABARAP/RRAS/SQSTM1/MRAS/TAX1BP1/GABARAPL2/BNIP3L/MITF/CALCOCO2/PINK1/SMURF2/HIF1A/FOXO3/TFEB/MTX1/FKBP8/CSNK2A2/RAB5C/CSNK2B/RAB7A/AMFR/RHOT1/BECN1/NBR1/CSNK2A1/RAB5B/TBK1/BCL2L13/BCL2L1/MAP1LC3A/CCZ1B/OPTN	5.78370874839601
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	38/1193	137/9376	2.17991813559633	CTSD/CTSS/CTSC/CTSZ/CTSH/BCL2A1/CTSB/BAX/LMNA/TRADD/NFKBIA/TNFSF10/CTSL/BIRC3/CFLAR/ITPR1/CYCS/NFKB1/PIK3R1/PARP4/GADD45B/GADD45G/ERN1/CTSO/CTSF/CASP3/CAPN2/BCL2L11/CASP8/RIPK1/BCL2L1/AIFM1/BAK1/CTSK/IKBKG/PIK3CA/FAS/CASP7	5.31189229799047
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	24/1193	70/9376	2.69457549994013	HLA-B/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/ITGB2/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DQA1/CD86/HLA-DQB1/HLA-DRB1/ITGAL/CYCS/CD40/SNTB1/CASP3/SNTB2/CASP8	5.43347913246292
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	31/1193	105/9376	2.32032890272622	TNFSF13B/CXCL2/LY96/BCL2A1/CXCL3/BTK/TRADD/RELB/NFKBIA/LTBR/BIRC3/CFLAR/BCL10/NFKB1/CSNK2A2/TLR4/CD40/GADD45B/TRAF3/CSNK2B/GADD45G/CSNK2A1/IRAK4/NFKB2/MYD88/RIPK1/BCL2L1/MAP3K7/TNFAIP3/PLCG2/IKBKG	5.19473112529916
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	11/1193	19/9376	4.55005073454802	HEXB/HEXA/GUSB/GNS/GLB1/NAGLU/HPSE/IDS/SGSH/GALNS/ARSB	5.91415401159443
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	48/1193	196/9376	1.92469678567152	HLA-B/HLA-A/HLA-C/HLA-F/HLA-E/CXCL2/STAT1/GNB4/BAX/CD86/CLEC2B/CXCL3/ZFP36/ATG3/IFNGR1/TRADD/NFKBIA/STAT2/JAK1/IFNAR1/HIF1A/ITPR1/CYCS/NFKB1/MAPK14/PIK3R1/IFNAR2/PIK3R5/TRAF3/IRF7/CDKN1A/CREBBP/BECN1/NFATC3/VEGFA/CASP3/TBK1/CASP8/BAK1/GNGT2/ATG14/E2F3/MAP1LC3A/PIK3C3/PLCG2/IKBKG/PIK3CA/FAS	4.99523158570812
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	20/1193	56/9376	2.8068494791043	IL18/ITGB2/CXCL2/PYCARD/CXCL3/CASP1/NFKBIA/CYCS/TLR5/NFKB1/TLR4/NFKB2/HSPA6/CASP3/MYD88/BCL2L13/CASP8/ARF1/NLRC4/CASP7	5.17794718862223
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	19/1193	52/9376	2.87162292862209	APOE/APOC1/LIPA/CYP27A1/NPC2/TSPO/LRPAP1/LPL/NCEH1/CD36/SOAT1/LRP1/PLTP/APOC2/STARD3/SCARB1/VAPA/STARD3NL/NPC1	5.1673571649973
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	17/1193	44/9376	3.03650080012192	HLA-B/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DQA1/CD86/HLA-DQB1/HLA-DRB1/FAS	5.16979286328976
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	23/1193	71/9376	2.54593107682136	ATP6V1F/CXCL2/ATP6V0D1/ATP6V1B2/ATP6V0B/CXCL3/ATP6V0E1/ATP6AP1/TCIRG1/NFKBIA/ATP6V1D/ADAM17/ATP6V1A/HBEGF/ATP6V1G1/NFKB1/MAPK14/ATP6V1H/CCL5/CASP3/PLCG2/ATP6V0E2/IKBKG	4.9924152102691
Human Diseases	Immune disease	hsa05310	Asthma	14/1193	32/9376	3.43839061190277	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DQA1/PRG2/HLA-DQB1/HLA-DRB1/FCER1G/CD40/IL10	5.27547338447173
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	17/1193	45/9376	2.96902300456366	HLA-B/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DQA1/CD86/HLA-DQB1/HLA-DRB1/FAS	5.05524882314747
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	56/1193	253/9376	1.73958102104172	IL18/CD44/RRAGD/BAX/PYCARD/CASP4/RIPK2/SQSTM1/CASP1/CAST/UBE2D1/TRADD/NFKBIA/CAPNS1/CALCOCO2/PRKCD/TLN1/ITPR1/FOXO3/CYCS/TLR5/CYTH1/BCL10/ARPC1B/NFKB1/MAPK14/ARPC3/TLR4/ARPC4/PIK3R1/TNIP1/WIPI1/ARHGEF2/RRAGC/RHOA/UBE2D3/CCL5/BECN1/U2AF1L4/TBK1/CAPN2/MYD88/HK3/RIPK1/BCL2L1/ATG14/MAP1LC3A/MAP3K7/ARF1/PIK3C3/NLRC4/ARPC5/PLCG2/IKBKG/PIK3CA/UBE2D4	4.55330524395603
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	51/1193	224/9376	1.78936654292899	B2M/HLA-B/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/TSPO/ITGB2/HLA-DPB1/HLA-DPA1/HLA-DOA/BAX/HLA-DQA1/SPI1/ZFP36/HLA-DQB1/STAT5A/SLC25A5/TGFBR2/RELB/NFKBIA/LTBR/JAK1/HLA-DRB1/ITGAL/ANAPC13/TLN1/IL2RG/NFKB1/PIK3R1/CD40/CDKN1A/CREBBP/CD4/NFATC3/VAC14/NFKB2/PRKACA/BCL2L1/E2F3/IL15/IKBKG/CREB5/RANBP3/ANAPC7/PIK3CA/IL15RA	4.56556261025418
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/1193	54/9376	2.76526652385831	HLA-B/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DQA1/CD86/HLA-DQB1/HLA-DRB1/CD40/IL10/FAS	4.96709195938847
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	14/1193	33/9376	3.33419695699662	STX6/VAMP8/STX11/VAMP5/STX4/SNAP29/VAMP3/STX7/STX8/STX18/VAMP7/VAMP4/STX17/STX3	5.12862421434445
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	18/1193	50/9376	2.82930427493713	HLA-DQA2/HLA-DMA/HLA-DMB/CXCR4/TNFSF13B/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DQA1/CD86/HLA-DQB1/LTBR/HLA-DRB1/CD40/IL10/IL15/IL15RA	4.95191099746257
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	30/1193	109/9376	2.16307666279597	LY96/STAT1/CD86/NFKBIA/STAT2/JAK1/IFNAR1/TLR5/TLR8/NFKB1/MAP3K8/MAPK14/TLR4/PIK3R1/CD40/CXCL9/IFNAR2/TRAF3/IRF7/CCL5/TLR7/IRAK4/TBK1/MYD88/CASP8/RIPK1/MAP3K7/CTSK/IKBKG/PIK3CA	4.66338845901488
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	29/1193	105/9376	2.17063026384066	LSP1/STAT1/RRAS/PYCARD/CASP1/MRAS/RELB/CLEC7A/NFKBIA/STAT2/PRKCD/FCER1G/ITPR1/BCL10/NFKB1/CLEC4E/MAPK14/IRF1/PIK3R1/RHOA/CARD9/BCL3/NFATC3/NFKB2/IL10/CASP8/PLCG2/IKBKG/PIK3CA	4.60575350220232
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	35/1193	138/9376	1.99326991994363	IL18/FN1/PYCARD/RHOG/CASP1/PKN1/WAS/NFKBIA/LIMK1/RPS6KA1/ARPC1B/NFKB1/MAPK14/ARPC3/TLR4/ARPC4/PIK3R1/SKAP2/WIPF3/RHOA/PKN2/PTK2B/CD4/IRAK4/NFATC3/PIP5K1C/TBK1/IL10/MYD88/MAP3K7/NLRC4/ARPC5/RPS6KA2/IKBKG/PIK3CA	4.48815071359175
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	31/1193	119/9376	2.04734903181725	CXCL2/CXCL3/CCL20/TRADD/NFKBIA/MMP9/BIRC3/ADAM17/CFLAR/NFKB1/MAP3K8/MAPK14/IRF1/PIK3R1/JUNB/TRAF3/BCL3/CCL5/SOCS3/CASP3/CASP8/RIPK1/MAP3K7/IL15/TNFAIP3/IKBKG/CREB5/PIK3CA/FAS/CASP7/CEBPB	4.39015009753082
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	30/1193	116/9376	2.0325461745238	SDS/FBP1/TKT/CAT/ME2/SDHD/SDHB/SDSL/PGD/ACAT1/ESD/SUCLG2/ADPGK/ACADS/SDHC/H6PD/SUCLG1/G6PD/ME1/MDH1/DLD/PRPS2/IDH3B/ACOX1/HIBCH/HK3/ACO1/CS/IDNK/ACSS2	4.27250488292151
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	35/1193	144/9376	1.91021700661265	ALDH2/CXCL2/LY96/C5AR1/C2/CXCL3/TRADD/NFKBIA/PRKAG2/ALDH9A1/ACADVL/ALDH3A2/FOXO3/NFKB1/LPIN2/CPT1A/ACADM/MAPK14/TLR4/C1QC/TRAF3/ADIPOR1/IRAK4/PRKAG1/CASP3/TBK1/ACOX1/MYD88/CASP8/RIPK1/MAP3K7/IKBKG/FAS/MLYCD/PRKAA1	4.20269504768956
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	15/1193	42/9376	2.8068494791043	FTL/FTH1/SAT1/GPX4/SAT2/PRNP/NCOA4/ACSL3/ATG7/SLC3A2/ACSL1/TFRC/MAP1LC3A/STEAP3/LPCAT3	4.48086960769993
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	47/1193	216/9376	1.71009903449132	OLR1/IL18/NCF2/CXCL2/LY96/CYBA/CD36/BAX/PYCARD/CXCL3/CASP1/RAP1A/NFKBIA/TNFSF10/NFE2L2/ABCG1/MMP9/ITPR1/CYCS/NCF1/NFKB1/ATF6/MAPK14/TLR4/PIK3R1/RAP1B/CD40/TRAF3/RHOA/IRF7/ERN1/CCL5/IRAK4/NFATC3/HSPA6/CASP3/TBK1/SOD2/MYD88/CASP8/BCL2L1/MAP3K7/IKBKG/PIK3CA/FAS/POU2F1/CASP7	4.0313234547839
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	22/1193	76/9376	2.27502536727401	OLR1/PLIN2/CYP27A1/FABP5/NR1H3/LPL/CD36/DBI/SCP2/PCK2/FABP3/PLTP/SLC27A1/ACSL3/ACAA1/GK/CPT1A/ACADM/ACSL1/ME1/ACOX1/FABP4	4.26121779197811
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	15/1193	43/9376	2.7415739098228	ALDH2/ACAA2/HADHB/HADHA/ACAT1/ACSL3/ALDH9A1/ACADVL/ACADS/ALDH3A2/ACAA1/CPT1A/ACADM/ACSL1/ACOX1	4.37033863309054
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	25/1193	93/9376	2.11268240362689	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/HLA-DPB1/STAT1/HLA-DPA1/HLA-DOA/HLA-DQA1/NOTCH2/IFNGR1/HLA-DQB1/STAT5A/NFKBIA/JAK1/HLA-DRB1/IFNGR2/IL2RG/NFKB1/MAPK14/NFKBIE/CD4/NFATC3/IKBKG/MAML3	4.11735300765332
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	48/1193	227/9376	1.66185273124061	B2M/HLA-B/HLA-A/HLA-C/HLA-F/CXCR4/HLA-E/GNB4/BAX/TAPBP/IL10RB/GNAI2/TAP1/GNA13/TAPBPL/TRADD/NFKBIA/IL10RA/EIF4EBP1/JAK1/PTGER4/ITPR1/CYCS/NFKB1/AKAP13/MAPK14/GRB2/PIK3R1/RHOA/PTK2B/CDKN1A/CCL5/NFATC3/SOS1/VEGFA/CASP3/TBK1/PRKACA/CASP8/RIPK1/BAK1/GNGT2/E2F3/IKBKG/CREB5/PIK3CA/FAS/ARHGEF11	3.85422500485535
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	36/1193	156/9376	1.81365658649816	CD81/NR1H3/STAT1/BAX/OAS1/TRADD/NFKBIA/STAT2/JAK1/CFLAR/IFNAR1/MX1/CYCS/OAS2/NFKB1/SCARB1/GRB2/PIK3R1/PIAS1/IFNAR2/TRAF3/IRF7/CDKN1A/SOCS3/SOS1/CASP3/TBK1/CASP8/RIPK1/BAK1/EIF3E/E2F3/IKBKG/PIK3CA/FAS/CLDN23	3.91279925815068
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	21/1193	75/9376	2.20056999161777	GSTO1/MGST1/BAX/SLC31A1/MGST2/ERCC1/BIRC3/CYCS/PIK3R1/CDKN1A/REV3L/XPA/CASP3/GSTM4/CASP8/BCL2L1/BAK1/GSTT1/MSH3/PIK3CA/FAS	3.98568413435724
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/1193	51/9376	2.46562464046809	ATP6V1F/ATP6V0D1/ATP6V1B2/ATP6V0B/ATP6V0E1/ATP6AP1/TCIRG1/KDELR1/ATP6V1D/ATP6V1A/ATP6V1G1/ATP6V1H/PRKACA/ARF1/PLCG2/ATP6V0E2	4.00712610627965
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	19/1193	66/9376	2.26249079224771	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/IL18/HLA-DPB1/STAT1/HLA-DPA1/HLA-DOA/HLA-DQA1/IFNGR1/HLA-DQB1/HLA-DRB1/IFNGR2/TLR5/IL2RG/NFKB1/TLR4/IL10	3.92984056341989
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	27/1193	109/9376	1.94676899651638	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/HLA-DPB1/STAT1/HLA-DPA1/HLA-DOA/HLA-DQA1/IFNGR1/HLA-DQB1/STAT5A/TGFBR2/NFKBIA/JAK1/HLA-DRB1/IFNGR2/HIF1A/IL2RG/NFKB1/MAPK14/NFKBIE/CD4/NFATC3/IL27RA/RARA/IKBKG	3.79609681196232
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	14/1193	42/9376	2.61972618049735	ALDH2/CAT/KYNU/AOC1/HADHA/ACAT1/CYP1B1/IL4I1/ALDH9A1/ALDH3A2/DLD/HAAO/AFMID/KMO	4.01681595446695
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/1193	57/9376	2.34396552991868	ACAA2/PPT1/HADHB/SCP2/HSD17B4/HADHA/ACAT1/ACSL3/ACADVL/ACADS/ACAA1/CPT1A/ACADM/ELOVL1/ACSL1/ACOX1/OXSM	3.88588985547089
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	31/1193	133/9376	1.83183860741544	CAT/GABARAPL1/GABARAP/HOMER3/GABARAPL2/SGK3/TGFBR2/TNFSF10/PCK2/PRKAG2/SGK1/BCL6/FOXO3/MAPK14/GRB2/PIK3R1/GADD45B/GADD45G/CDKN1A/CREBBP/IL7R/PRKAG1/SOS1/CDKN1B/IL10/SOD2/BCL2L11/S1PR4/FBXO25/PIK3CA/PRKAA1	3.68899444665339
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	35/1193	157/9376	1.7520461716702	LIPA/NR1H3/CD36/ALOX5/DUSP2/HAVCR2/LRP1/CASP1/TMEM30A/SGK1/NR1H2/PTGER4/RAB14/ADAM17/HIF1A/PLA2G15/VPS41/CPT1A/RAB5C/MAPK14/CD47/SIRPB1/C1QC/VPS8/RAB7A/NFATC3/RAB5B/CASP3/IL10/SPHK1/VPS18/VPS39/CASP7/GPR132/CEBPB	3.6282901348045
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	36/1193	163/9376	1.73576949382646	STAT1/BAX/ATP6AP1/STAT5A/TGFBR2/NFKBIA/IFIH1/STAT2/MMP9/JAK1/IFNAR1/CYCS/NFKB1/MAPK14/GRB2/TLR4/PIK3R1/TRAF3/IRF7/PTK2B/CDKN1A/CREBBP/DDB2/IRAK4/NFATC3/SOS1/CASP3/TBK1/MYD88/CASP8/E2F3/MAP3K7/IKBKG/CREB5/PIK3CA/FAS	3.61813384328644
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	25/1193	100/9376	1.96479463537301	CD9/HLA-DQA2/HLA-DMA/HLA-DMB/CD37/HLA-DRA/CD44/HLA-DPB1/HLA-DPA1/CD36/HLA-DOA/CSF3R/HLA-DQA1/ANPEP/CD59/HLA-DQB1/FCGR1A/HLA-DRB1/ITGA6/CD1D/IL7R/TFRC/CD4/CD22/CD38	3.7034296088506
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/1193	30/9376	2.88169879854708	SDHD/SDHB/PCK2/SUCLG2/SDHC/SUCLG1/MDH1/DLD/IDH3B/ACO1/CS	3.94137203719065
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	44/1193	214/9376	1.61590586834416	B2M/HLA-B/HLA-A/HLA-C/HLA-F/CXCR4/HLA-E/AP1S2/GNB4/BAX/TAPBP/GNAI2/TAP1/APOBEC3C/TAPBPL/TRADD/NFKBIA/APOBEC3G/LIMK1/ITPR1/CYCS/NFKB1/MAPK14/TLR4/PIK3R1/BST2/PTK2B/SAMHD1/CD4/IRAK4/NFATC3/CASP3/TBK1/MYD88/CASP8/RIPK1/BCL2L1/BAK1/GNGT2/MAP3K7/PLCG2/IKBKG/PIK3CA/FAS	3.47997135780641
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/1193	227/9376	1.59260886743891	NCF2/GSTO1/CAT/CYBA/MGST1/NDUFB5/SDHD/AKR1A1/SDHB/EPHX1/UQCRB/MGST2/UQCRC2/HGF/NDUFB9/PPIF/SLC25A5/NFKBIA/CYP1B1/CBR1/NFE2L2/PRKCD/SDHC/COX7A2L/HIF1A/FOXO3/NCF1/NFKB1/MAPK14/GRB2/PIK3R1/NDUFS3/NDUFA8/PTPN1/NDUFS8/PLD2/SOS1/VEGFA/PLD1/SOD2/GSTM4/COX7C/GSTT1/COX6A1/IKBKG/PIK3CA	3.45099114526694
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	35/1193	160/9376	1.71919530595138	HLA-B/HLA-A/HLA-C/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-F/HLA-E/HLA-DRA/ITGB2/HLA-DPB1/HLA-DPA1/HLA-DOA/CADM1/ALCAM/HLA-DQA1/CD86/SDC2/CD99/CD58/HLA-DQB1/GLG1/HLA-DRB1/ITGAL/SDC3/ITGA6/SPN/PTPRC/CD40/SELPLG/CD4/CD22/ICAM2/PDCD1LG2/CLDN23	3.50336338688763
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	16/1193	55/9376	2.28630648479768	PSAP/ASAH1/HEXB/HEXA/GM2A/GALC/GLA/DEGS1/GLB1/CERS2/UGCG/ARSA/SPHK1/SGMS2/CERK/B4GALT5	3.65295341907402
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	37/1193	174/9376	1.67120463238624	BAX/DNAJC5B/UBE2D1/MAN1A1/NFE2L2/STUB1/SIL1/UBXN6/SEC63/BCAP29/DNAJB12/DNAJA2/DERL1/ATF6/DNAJC1/RNF5/NGLY1/SEL1L/FBXO6/HERPUD1/UBE2D3/UBXN1/AMFR/ERN1/MAN1B1/ERP29/DNAJC5/TRAM1/BCAP31/HSPA6/PPP1R15A/CAPN2/EDEM2/EDEM1/BAK1/PLAA/UBE2D4	3.41222797568692
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	24/1193	99/9376	1.90525540399807	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/CFD/ITGB2/FCGR3A/HLA-DPB1/C5AR1/HLA-DPA1/C2/HLA-DOA/HLA-DQA1/FPR3/HLA-DQB1/FCGR1A/HLA-DRB1/ITGAL/PTAFR/FPR1/C1QC/SELPLG/CAMP/IL10	3.45727980628357
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	41/1193	200/9376	1.61113160100587	IL18/BAX/PYCARD/CASP4/CASP1/GNA13/NCK1/TRADD/MYO1F/NFKBIA/TNFSF10/MYO1E/CYCS/TLR5/CYTH1/ARPC1B/NFKB1/MAPK14/ARPC3/TLR4/ARPC4/ABI1/ARHGEF2/WIPF3/RHOA/BRK1/IRAK4/CASP3/MYD88/CASP8/RIPK1/BAK1/MAP3K7/ARF1/ARPC5/IKBKG/TMBIM6/FAS/CASP7/CLDN23/ARHGEF11	3.33558967667458
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	20/1193	77/9376	2.04134507571222	STAT1/BAX/RALA/TGFBR2/JAK1/NFKB1/PIK3R1/GADD45B/RALGDS/GADD45G/CDKN1A/PLD2/DDB2/VEGFA/PLD1/BCL2L1/BAK1/E2F3/IKBKG/PIK3CA	3.50325290546371
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/1193	83/9376	1.89377796180531	DNASE2/IL18/POLR3GL/PYCARD/CASP1/IFI16/NFKBIA/TREX1/NFKB1/IRF7/CCL5/SAMHD1/CASP3/TBK1/CASP8/RIPK1/IKBKG/POLR3C/AIM2/CASP7	3.12277219637672
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/1193	31/9376	2.53521888435227	ALDH2/HADHA/DPYD/ALDH9A1/ACADS/ALDH3A2/ALDH3B1/ACOX1/HIBCH/MLYCD	3.26897110969563
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	18/1193	73/9376	1.9378796403679	CXCR4/ELL2/MDFIC/SUPT4H1/APOBEC3C/RANBP2/SERINC3/PDCD6IP/APOBEC3G/MX1/CHMP4B/BST2/TSG101/CREBBP/CDK9/SAMHD1/CD4/MAP1S	3.07147236550347
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	32/1193	157/9376	1.60187078552704	NR1H3/CEBPA/BAX/NDUFB5/SDHD/SDHB/UQCRB/UQCRC2/NDUFB9/PRKAG2/SDHC/COX7A2L/CYCS/NFKB1/MAPK14/PIK3R1/NDUFS3/NDUFA8/ADIPOR1/ERN1/NDUFS8/SOCS3/PRKAG1/CASP3/BCL2L11/CASP8/COX7C/COX6A1/PIK3CA/FAS/CASP7/PRKAA1	2.90376032192935
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	59/1193	333/9376	1.392467068913	HLA-B/HLA-A/HLA-C/HLA-F/HLA-E/ATP6V1F/STAT1/ATP6V0D1/FN1/BAX/ATP6V1B2/ATP6V0B/NOTCH2/ATP6V0E1/ATP6AP1/TCIRG1/TRADD/STAT2/ATP6V1D/EIF4EBP1/JAK1/UBE3A/PTGER4/ATP6V1A/IFNAR1/ITGA6/MX1/TADA3/ATP6V1G1/NFKB1/PPP2R5E/GRB2/IRF1/PIK3R1/IFNAR2/ATP6V1H/TRAF3/CDKN1A/CREBBP/PSEN1/PPP2R5A/SOS1/CDKN1B/BCAP31/VEGFA/CASP3/TBK1/PRKACA/CASP8/BAK1/LFNG/ATP6V0E2/HES4/IKBKG/CREB5/MAML3/PIK3CA/FAS/THBS3	2.78431686288307
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	7/1193	18/9376	3.05634721058024	HEXB/HEXA/FUCA1/MANBA/GLB1/AGA/MAN2B1	3.33419321152232
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/1193	32/9376	2.45599329421626	HADHA/SUCLG2/ECHDC1/ACADS/SUCLG1/DLD/ACOX1/HIBCH/ACSS2/MLYCD	3.15005062524146
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/1193	32/9376	2.45599329421626	GABARAPL1/GABARAP/ATG3/IGBP1/GABARAPL2/ATG7/WIPI1/ATG4C/BECN1/PIK3C3	3.15005062524146
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1193	32/9376	2.45599329421626	BAX/BIRC3/CYCS/BECN1/CASP3/BCL2L11/CASP8/BCL2L1/BAK1/CASP7	3.15005062524146
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1193	75/9376	1.88620284995809	ZNF385A/BAX/CD82/TP53I3/SERPINE1/CYCS/RRM2B/GADD45B/GADD45G/CDKN1A/DDB2/CCNG1/CASP3/ZMAT3/CASP8/BCL2L1/STEAP3/FAS	2.94203975075254
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	20/1193	87/9376	1.80670771068782	BAX/RALA/TGFBR2/EREG/CYCS/GRB2/PIK3R1/GADD45B/AREG/RHOA/RALGDS/GADD45G/CDKN1A/DDB2/SOS1/CASP3/BCL2L11/BAK1/MSH3/PIK3CA	2.88629646431055
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	13/1193	48/9376	2.12852752165409	ALDH2/ACAA2/HADHB/HADHA/ACAT1/IL4I1/ALDH9A1/ACADS/ALDH3A2/ACAA1/ACADM/DLD/HIBCH	2.99287162786566
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	21/1193	93/9376	1.77465321904659	FN1/BAX/NFKBIA/MAX/BIRC3/ITGA6/CYCS/NFKB1/PIK3R1/GADD45B/TRAF3/GADD45G/CDKN1A/DDB2/CDKN1B/CASP3/BCL2L1/BAK1/E2F3/IKBKG/PIK3CA	2.86651496503698
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	17/1193	70/9376	1.90865764579092	CD36/TRADD/NFKBIA/PCK2/PRKAG2/ACSL3/NFKB1/CPT1A/NFKBIE/ACSL1/ADIPOR1/SOCS3/PRKAG1/POMC/IKBKG/AGRP/PRKAA1	2.91351571950162
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/1193	28/9376	2.52616453119387	ATP6V1F/ATP6V0D1/ATP6V1B2/ATP6V0E1/TCIRG1/ATP6V1D/ATP6V1A/ATP6V1G1/ATP6V0E2	3.08795245121009
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	33/1193	168/9376	1.54376721350736	FTL/FTH1/CHMP1B/STAT1/GLUL/BAX/PYCARD/SQSTM1/CASP1/IFNGR1/STAT5A/SLC25A5/TRADD/TNFSF10/STAT2/JAK1/BIRC3/IFNGR2/CFLAR/IFNAR1/CHMP3/CHMP5/TLR4/IFNAR2/CHMP4B/CAPN2/PYGB/CASP8/RIPK1/AIFM1/TNFAIP3/FAS/PLA2G4C	2.71540484282795
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	18/1193	77/9376	1.837210568141	BAX/STAT5A/TGFBR2/NFKBIA/NFKB1/GRB2/PIK3R1/GADD45B/GADD45G/CDKN1A/DDB2/SOS1/CDKN1B/BCL2L1/BAK1/E2F3/IKBKG/PIK3CA	2.81651147514084
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	38/1193	201/9376	1.48581484864029	NUPR1/BCL2A1/CEBPA/BAX/CD86/ID2/SPI1/PBX3/TGFBR2/FCGR1A/MITF/NCOR1/MMP9/MAX/BIRC3/LYL1/BCL6/KMT2A/NFKB1/PTCRA/CD40/SPINT1/GADD45B/REL/GADD45G/CDKN1A/CDK9/FLI1/DDB2/CDKN1B/CDK14/PML/BCL2L1/BAK1/RARA/LDB1/CEBPB/RUNX2	2.65836959650344
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/1193	15/9376	3.14367141659681	HEXB/HEXA/GLB1/ST6GALNAC4/B3GALT4/ST6GALNAC6	3.17243190220162
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	31/1193	157/9376	1.55181232347932	HLA-B/HLA-A/HLA-C/HLA-F/HLA-E/RRAS/SQSTM1/MRAS/ZFP36L2/SLC25A5/TGFBR2/PPP1CC/NBN/HIPK2/EIF4EBP1/SERPINE1/ITPR1/FOXO3/NFKB1/MAPK14/PIK3R1/GADD45B/GADD45G/CDKN1A/HUS1/NFATC3/RASSF5/CAPN2/E2F3/PIK3CA/MCU	2.6622503843043
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	18/1193	78/9376	1.81365658649816	ITGB2/LY96/C2/SERPING1/PYCARD/CASP1/GNAI2/NFKB1/MAPK14/TLR4/IRF1/C1QC/RHOA/IRAK4/CASP3/IL10/MYD88/CASP7	2.75513738125967
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	13/1193	50/9376	2.04338642078793	CD81/IL18/ITGB2/CD36/SDC2/LRP1/HGF/ITGAL/TLR4/CD40/IL10/MYD88/THBS3	2.82443810058905
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	20/1193	90/9376	1.74648412033156	STAT1/IFNGR1/NFKBIA/JAK1/IFNGR2/HIF1A/NFKB1/CSNK2A2/MAPK14/TLR4/PIK3R1/NFKBIE/CSNK2B/CD4/CSNK2A1/NFATC3/MYD88/IKBKG/BATF/PIK3CA	2.71692139084208
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	19/1193	85/9376	1.75675755633351	TYMP/UPP1/GMPR2/NME4/TK2/DCTD/NT5C3A/RRM2B/HDDC2/IMPDH1/NME3/AK3/ADSL/LACC1/CDA/AMPD3/CMPK2/AMPD2/GMPR	2.6759905991672
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	23/1193	109/9376	1.65835877481025	NR1H3/CD36/PPP1CC/NFKBIA/PCK2/PRKAG2/SLC27A1/NR1H2/PRKCD/RPS6KA1/NFKB1/CPT1A/PIK3R1/PTPN1/SLC27A3/SOCS3/PRKAG1/PYGB/RPS6KA2/PPARGC1B/CREB5/PIK3CA/PRKAA1	2.63970794922557
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	20/1193	91/9376	1.72729198714111	CD81/CD72/LILRB4/RASGRP3/BTK/NFKBIA/BCL10/NFKB1/DAPP1/GRB2/PIK3R1/NFKBIE/CD22/NFATC3/SOS1/LILRB3/LILRA2/PLCG2/IKBKG/PIK3CA	2.66187789272526
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	15/1193	62/9376	1.9014141632642	NOTCH2/APH1B/PSENEN/CIR1/TLE3/NCSTN/NUMB/ADAM17/PTCRA/APH1A/ATXN1/CREBBP/PSEN1/LFNG/MAML3	2.71895293444972
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	21/1193	98/9376	1.68410968746258	FCGR3A/MARCKS/WAS/FCGR1A/PRKCD/LIMK1/PTPRC/ARPC1B/NCF1/ARPC3/ARPC4/PIK3R1/GSN/PLD2/PIP5K1C/PLD1/SPHK1/ARPC5/PLCG2/PIK3CA/PLA2G4C	2.59932855982568
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	36/1193	193/9376	1.46596076421613	CXCR4/CXCL16/CXCL2/STAT1/GNB4/CCL18/CXCL3/GNAI2/ARRB2/CCL20/FGR/WAS/RAP1A/NFKBIA/DOCK2/STAT2/PRKCD/FOXO3/NCF1/NFKB1/GRB2/PIK3R1/TIAM1/RAP1B/CXCL9/PIK3R5/RHOA/PTK2B/CCL5/SOS1/PRKACA/GNGT2/GRK6/PLCG2/IKBKG/PIK3CA	2.49738383135779
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	32/1193	168/9376	1.49698638885563	STAT1/CSH1/CSF3R/OSM/IL10RB/IFNGR1/CSH2/STAT5A/IL10RA/STAT2/JAK1/IFNGR2/IFNAR1/STAM/IL2RG/GRB2/PIK3R1/PTPN2/PIAS1/IFNAR2/CDKN1A/CREBBP/IL7R/SOCS3/SOS1/IL10/IL27RA/BCL2L1/IL15/SOCS1/PIK3CA/IL15RA	2.48179591118335
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1193	31/9376	2.28169699591704	CAT/GLUL/ACAT1/MDH1/DLD/ACO1/CS/AFMID/ACSS2	2.7291420746197
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/1193	47/9376	2.00659877655116	ALDH2/ME2/AKR1A1/ACAT1/PCK2/ALDH9A1/ACYP2/ALDH3A2/ME1/MDH1/DLD/ACSS2	2.6414194114133
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/1193	138/9376	1.53766536681366	ATP6V1F/ATP6V0D1/ATP6V1B2/NDUFB5/SDHD/ATP6V0B/ATP6V0E1/SDHB/ATP6AP1/UQCRB/UQCRC2/NDUFB9/TCIRG1/ATP6V1D/ATP6V1A/SDHC/COX7A2L/ATP6V1G1/CYCS/NDUFS3/NDUFA8/ATP6V1H/NDUFS8/COX7C/COX6A1/ATP6V0E2/LHPP	2.42947375258806
NA	NA	hsa03272	Virion - Hepatitis viruses	12/1193	48/9376	1.96479463537301	CD81/CD9/CHMP1B/LAMP2/PDCD6IP/LAMP1/TGOLN2/CD63/SCARB1/CHMP4B/TSG101/CLDN23	2.55864959916319
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/1193	22/9376	2.50064771774747	ALDH2/HNMT/AOC1/ALDH9A1/ALDH3A2/ALDH3B1/AMDHD1	2.69054954743804
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	10/1193	38/9376	2.06820487934001	TAP1/BTK/PTPRC/IL2RG/CIITA/CD40/IL7R/CD4/IKBKG/RFX5	2.51923687940751
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	29/1193	154/9376	1.47997517989136	ALDH2/GUSB/AKR1A1/KYNU/PPCS/NME4/COQ2/DHRS3/VKORC1/RDH11/ALDH3A2/PDXK/MOCS2/ALAS1/NME3/AK3/ADSL/UROD/DLD/HAAO/OXSM/FPGS/PANK3/CMPK2/AFMID/ALAD/KMO/NADSYN1/NMNAT1	2.29306394618503
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1193	44/9376	1.96479463537301	STX4/DCTN2/RAB11B/DYNC1LI1/RAB5C/NSF/RAB5B/ARHGDIB/PRKACA/DCTN1/CREB5	2.44919541411082
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/1193	79/9376	1.69121563551094	ATP6V1F/ATP6V0D1/ATP6V1B2/ATP6V0B/ATP6V0E1/TCIRG1/ATP6V1D/ATP6V1A/ATP6V1G1/SLC1A3/ATP6V1H/AP2A1/AP2S1/NSF/AP2M1/ATP6V0E2/STX3	2.35562019039104
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	16/1193	73/9376	1.72255968032702	BAX/HGF/STAT5A/FOXO3/GRB2/PIK3R1/GADD45B/GADD45G/CDKN1A/DDB2/SOS1/RASSF5/BAK1/E2F3/PLCG2/PIK3CA	2.36631865649723
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	27/1193	142/9376	1.49435084943863	NCF2/GSTO1/DUSP1/CYBA/MGST1/SDC2/SQSTM1/MGST2/CTSL/NFE2L2/MMP9/SUMO3/NCF1/NFKB1/MAPK14/PIK3R1/ARHGEF2/RHOA/BMPR2/SUMO2/VEGFA/GSTM4/MAP3K7/GSTT1/IKBKG/PIK3CA/PRKAA1	2.26638718715022
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	21/1193	104/9376	1.58694951318589	PLD3/AGPAT2/GPCPD1/PLA2G15/CHPT1/LPIN2/CDS2/PLD2/CRLS1/CEPT1/PTDSS1/PNPLA6/PLD1/AGPAT4/PISD/LYPLA2/SGMS2/LPCAT3/MBOAT1/GPD2/PLA2G4C	2.29816014810944
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1193	83/9376	1.60971126753451	GSTK1/CAT/SCP2/HSD17B4/MPV17/ACSL3/DHRS4/ACAA1/ACSL1/PEX16/ACOX1/SOD2/PRDX1/MLYCD/PEX14/NUDT7/CRAT	2.13027113605328
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1193	65/9376	1.69274614739828	ALDH2/LPL/MGLL/AKR1A1/AGPAT2/GLA/ALDH9A1/ALDH3A2/GK/LPIN2/DGAT1/PNPLA2/AGPAT4/MBOAT1	2.13984451882057
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	13/1193	59/9376	1.7316834074474	GPX1/GSTO1/GSTK1/MGST1/ANPEP/GPX4/MGST2/SMS/PGD/RRM2B/G6PD/GSTM4/GSTT1	2.1525871781184
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	23/1193	122/9376	1.48164841355997	FBP1/CD36/PFKFB3/PCK2/PRKAG2/EIF4EBP1/RAB14/FOXO3/RAB11B/RAB8A/PPP2R5E/CPT1A/PIK3R1/ADIPOR1/TBC1D1/PPP2R5A/PRKAG1/MAP3K7/STRADB/CREB5/PIK3CA/MLYCD/PRKAA1	2.04453658557157
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	20/1193	103/9376	1.52605408572661	GNAI2/IFNGR1/TGFBR2/NFKBIA/IFNGR2/SERPINE1/CFLAR/NFKB1/MAPK14/TLR4/PIK3R1/C1QC/CCL5/IRAK4/IL10/MYD88/CASP8/IKBKG/PIK3CA/FAS	2.04969133385828
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/1193	72/9376	1.63732886281084	AZI2/TRADD/NFKBIA/IFIH1/NFKB1/MAPK14/TRAF3/IRF7/TBK1/CASP8/RIPK1/DHX58/MAP3K7/RNF125/IKBKG	2.07273875975082
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1193	31/9376	2.02817510748182	FBP1/TKT/PGD/H6PD/G6PD/PRPS2/DERA/IDNK	2.18931303954377
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	35/1193	205/9376	1.34181097049864	HLA-B/HLA-A/HLA-C/HLA-F/HLA-E/ATP6V0D1/BAX/STAT5A/TRADD/NFKBIA/LTBR/JAK1/UBE3A/NFKB1/GRB2/PIK3R1/REL/TRAF3/RHOA/IRF7/CDKN1A/CREBBP/GSN/VAC14/CDKN1B/NFKB2/CASP3/PRKACA/GTF2H1/CASP8/BAK1/IKBKG/CREB5/PIK3CA/HDAC10	1.88931409958223
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/1193	68/9376	1.61806617030718	BCL2A1/CEBPA/SPI1/STAT5A/FCGR1A/EIF4EBP1/NFKB1/GRB2/PIK3R1/SOS1/PML/RARA/IKBKG/PIK3CA	1.95303859971807
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1193	38/9376	1.86138439140601	HEXB/HEXA/GNPDA1/NAGK/RENBP/HK3/CHIT1/UAP1L1/UAP1	2.0314748304808
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	24/1193	133/9376	1.41819763154744	HLA-B/HLA-A/HLA-C/TYROBP/CD48/HLA-E/ITGB2/FCGR3A/IFNGR1/TNFSF10/IFNGR2/ITGAL/IFNAR1/FCER1G/GRB2/PIK3R1/IFNAR2/PTK2B/SOS1/ICAM2/CASP3/PLCG2/PIK3CA/FAS	1.85460103273569
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/1193	94/9376	1.50494908241337	CXCL2/CXCL3/S100A8/S100A9/CCL20/TRADD/NFKBIA/MMP9/NFKB1/MAPK14/TRAF3/CASP3/TBK1/CASP8/MAP3K7/TNFAIP3/IKBKG/CEBPB	1.87862594771493
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1193	59/9376	1.59847699148991	TYMP/UPP1/DPYD/NME4/TK2/DCTD/NT5C3A/RRM2B/HDDC2/NME3/CDA/CMPK2	1.76069852776135
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	27/1193	158/9376	1.34302418114104	ATP6V1F/RRAGD/ATP6V1B2/MAPKAP1/SGK1/ATP6V1D/EIF4EBP1/LAMTOR2/LAMTOR4/ATP6V1A/RPS6KA1/ATP6V1G1/LPIN2/GRB2/PIK3R1/SLC3A2/LAMTOR1/DDIT4/RRAGC/ATP6V1H/RHOA/SOS1/FNIP1/RPS6KA2/STRADB/PIK3CA/PRKAA1	1.66029214148427
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1193	18/9376	2.18310515041445	TCN2/MMADHC/LMBRD1/THAP11/PRDX1	1.91830501227266
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	22/1193	125/9376	1.3832154233026	CTSD/ASAH1/BAX/GNAI2/GNA13/TRADD/DEGS1/CERS2/FCER1G/NFKB1/PPP2R5E/MAPK14/PIK3R1/RHOA/NSMAF/PLD2/PPP2R5A/PLD1/S1PR4/SPHK1/SGMS2/PIK3CA	1.64684691398705
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	21/1193	120/9376	1.37535624476111	BAX/RIPK2/RAP1A/NFKBIA/PRKCD/RPS6KA1/FOXO3/NFKB1/MAPK14/GRB2/PIK3R1/RAP1B/NFKBIE/RHOA/PSEN1/IRAK4/SOS1/ARHGDIB/RPS6KA2/PLCG2/PIK3CA	1.58005491098915
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	28/1193	170/9376	1.29445293624575	GSTO1/MGST1/BAX/MGST2/HGF/TGFBR2/NFE2L2/TXNRD1/GRB2/PIK3R1/PBRM1/GADD45B/ARID1B/GADD45G/CDKN1A/SMARCC2/DDB2/TXNRD2/SOS1/GSTM4/BCL2L1/BAK1/E2F3/GSTT1/SMARCD1/PLCG2/PIK3CA/FRAT1	1.47929384161443
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1193	122/9376	1.3528094210765	NCK1/NFKBIA/PTPRC/BCL10/NFKB1/PPP2R5E/MAP3K8/MAPK14/GRB2/PIK3R1/NFKBIE/RHOA/CD4/PPP2R5A/NFATC3/SOS1/IL10/MAP3K7/IKBKG/TEC1/PIK3CA	1.49763136100397
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1193	82/9376	1.43765461124854	GSTO1/TYMP/MGST1/GUSB/UPP1/MGST2/DPYD/NME4/TK2/RRM2B/IMPDH1/NME3/CDA/GSTM4/GSTT1	1.51980085760163
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	20/1193	116/9376	1.35503078301587	CXCR4/ITGB2/NCF2/CYBA/GNAI2/CD99/RAP1A/MMP9/ITGAL/NCF1/MAPK14/PIK3R1/RAP1B/SIPA1/RHOA/PTK2B/RASSF5/PLCG2/PIK3CA/CLDN23	1.46905851907524
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	46/1193	300/9376	1.20507404302878	DUSP1/VEGFB/MAP3K2/RRAS/DUSP2/HGF/MRAS/ARRB2/DUSP10/RASGRP3/TRADD/TGFBR2/RELB/RAP1A/EREG/MAX/RPS6KA1/NFKB1/MAPKAPK3/MAP3K8/CACNA2D4/MAPK14/GRB2/RAP1B/TAOK3/GADD45B/AREG/FLNA/GADD45G/IRAK4/NFATC3/SOS1/NFKB2/VEGFA/HSPA6/CASP3/PRKACA/MYD88/PPM1A/RAPGEF2/HSPB1/MAP3K7/RPS6KA2/IKBKG/FAS/PLA2G4C	1.3783949134404
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/1193	110/9376	1.35749447534862	PFKFB3/IFNGR1/LTBR/EIF4EBP1/IFNGR2/SERPINE1/HIF1A/NFKB1/TLR4/PIK3R1/CUL2/CDKN1A/CREBBP/TFRC/CDKN1B/VEGFA/HK3/PLCG2/PIK3CA	1.44002195582839
Organismal Systems	Immune system	hsa04611	Platelet activation	21/1193	126/9376	1.30986309024867	APBB1IP/VAMP8/FERMT3/GNAI2/TBXAS1/GNA13/BTK/PPP1CC/RAP1A/TLN1/FCER1G/ITPR1/MAPK14/PIK3R1/RAP1B/PIK3R5/RHOA/PRKACA/PLCG2/PIK3CA/PLA2G4C	1.33700748440203
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1193	21/9376	1.87123298606953	ALDH2/PPCS/DPYD/ALDH3A2/PANK3	1.52606012950287
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1193	27/9376	1.74648412033156	SCP2/HSD17B4/ACAA1/ELOVL1/ACOT2/ACOX1	1.48309667148955
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/1193	59/9376	1.46527057553241	BAX/FOXO3/GRB2/PIK3R1/GADD45B/GADD45G/CDKN1A/DDB2/SOS1/BAK1/PIK3CA	1.36880987740431
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	32/1193	205/9376	1.22679860159876	CTSD/NCF2/CYBA/CD36/NDUFB5/SDHD/SDHB/UQCRB/UQCRC2/NDUFB9/PPIF/SLC25A5/TGFBR2/PPP1CC/MPC1/PDK4/MMP9/PRKCD/SDHC/COX7A2L/NCF1/NFKB1/MAPK14/PIK3R1/NDUFS3/NDUFA8/G6PD/NDUFS8/PDK2/COX7C/COX6A1/PIK3CA	1.2535987219514
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	23/1193	142/9376	1.27296553841068	UBE2R2/UBE2L6/UBE2D1/UBE2E2/STUB1/HERC1/BIRC3/UBE3A/SMURF2/ANAPC13/PIAS1/UBE2E1/CUL2/UBE2D3/UBE4A/UBA3/UBA6/SOCS3/DDB2/PML/SOCS1/ANAPC7/UBE2D4	1.25143023318368
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	36/1193	235/9376	1.2039592659307	MGLL/NDUFB5/SDHD/SDHB/UQCRB/UQCRC2/NDUFB9/PRKAG2/COX14/ACSL3/SLC25A20/SDHC/COX7A2L/RPS6KA1/CPT1A/MAPK14/GRB2/NDUFS3/NDUFA8/ACSL1/COA5/ARID1B/PNPLA2/NDUFS8/SMARCC2/PRKAG1/SOS1/PRKACA/COX7C/COX6A1/RPS6KA2/SMARCD1/CREB5/SLC25A29/NDUFAF1/PRKAA1	1.2090105799216
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1193	16/9376	1.96479463537301	HEXB/HEXA/GLA/GBGT1	1.47470968134563
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1193	28/9376	1.68410968746258	ACAA2/PPT1/HADHB/HADHA/ELOVL1/ACOT2	1.38418770920073
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/1193	115/9376	1.29847297642042	GNAI2/ARRB2/GNA13/SGK1/HBEGF/ITPR1/AKAP13/PDE4B/RHOA/CDKN1A/PLD2/OXSR1/PDE4A/PLD1/PRKACA/VDR/CREB5/ARHGEF11/RUNX2	1.2296303641865
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	30/1193	195/9376	1.20910439099878	ITGB2/NCF2/FCGR3A/CYBA/C5AR1/FPR3/CASP4/CASP1/PPIF/SLC25A5/AQP9/FCGR1A/CLEC7A/ITGAL/ATG7/TLR8/NCF1/NFKB1/SIGLEC9/MAPK14/TLR4/PIK3R1/FPR1/SELPLG/TLR7/CAMP/MAP3K7/PLCG2/PIK3CA/HDAC10	1.12663969609431
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1193	103/9376	1.29714597286762	ITGB2/CXCL2/FN1/CXCL3/NFKB1/RAB5C/TLR4/PIK3R1/RAB7A/CD1D/RAB5B/CASP3/IL10/PRKACA/PRDX1/HSPB1/PIK3CA	1.15778499208192
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1193	17/9376	1.84921848035107	CYP27A1/SCP2/HSD17B4/HSD3B7	1.33806976665029
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1193	17/9376	1.84921848035107	LAMP2/LAMP1/NRP2/TFRC	1.33806976665029
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/1193	90/9376	1.30986309024867	CAT/BAX/PRKAG2/EIF4EBP1/RB1CC1/FOXO3/NFKB1/PIK3R1/ADIPOR1/PRKAG1/PRKACA/SOD2/CREB5/PIK3CA/PRKAA1	1.12778508637949
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	31/1193	204/9376	1.19428693522673	PLAUR/CD44/FN1/RRAS/SDC2/HGF/MRAS/TIMP3/PPP1CC/CTSL/MMP9/HPSE/HBEGF/HIF1A/ITPR1/CD63/MAPK14/GRB2/TLR4/PIK3R1/TIAM1/RHOA/FLNA/CDKN1A/SOS1/VEGFA/CASP3/PRKACA/PLCG2/PIK3CA/FAS	1.07121400675045
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	56/1193	388/9376	1.13431442866895	APOE/LPL/RTN3/NDUFB5/SDHD/SDHB/LRP1/UQCRB/APH1B/UQCRC2/PSENEN/NDUFB9/PPIF/SLC25A5/SNCA/NCSTN/ADAM17/SLC39A11/SDHC/COX7A2L/RB1CC1/ITPR1/CYCS/NFKB1/NRBF2/ATF6/CSNK2A2/SLC39A3/RTN4/PIK3R1/NDUFS3/APH1A/WIPI1/NDUFA8/PSMC2/CSNK2B/ERN1/PSEN1/NDUFS8/BECN1/BACE1/CDK5/CSNK2A1/CASP3/CAPN2/CASP8/ATG14/COX7C/PIK3C3/COX6A1/IKBKG/PIK3CA/FRAT1/FAS/CASP7/MCU	1.03170749235745
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1193	70/9376	1.34728774997006	HGF/RAP1A/HIF1A/GRB2/PIK3R1/RAP1B/CUL2/CDKN1A/CREBBP/SOS1/VEGFA/PIK3CA	1.11354185310068
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1193	30/9376	1.57183570829841	PIGT/PIGP/PIGK/B3GALT4/PIGH/PIGC	1.19775666131832
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1193	37/9376	1.48687161595795	BAX/NCOA4/GADD45B/GADD45G/CDKN1A/DDB2/BAK1	1.13296036043266
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1193	71/9376	1.32831186616767	STAT1/STAT5A/FOXO3/NFKB1/MAPK14/GRB2/IRF1/PIK3R1/SOCS3/SOS1/SOCS1/PIK3CA	1.06024723801881
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	23/1193	149/9376	1.21316178828401	RRAS/RALA/AGPAT2/MRAS/GNA13/FCER1G/CYTH1/GRB2/PIK3R1/PIK3R5/RHOA/RALGDS/PTK2B/PLD2/SOS1/PIP5K1C/PLD1/AGPAT4/ARF1/SPHK1/PLCG2/PIK3CA/PLA2G4C	1.00143280368071
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1193	12/9376	1.96479463537301	ASGR1/CD46/NPC1	1.27686324236873
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/1193	44/9376	1.42894155299855	HEXB/HEXA/MGAT1/MAN1A1/MGAT4B/ALG13/MAN1B1/MAN2A2	1.08889668952135
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/1193	44/9376	1.42894155299855	TAF12/TAF10/GTF2F1/CCNH/GTF2H5/GTF2I/TAF3/GTF2H1	1.08889668952135
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	20/1193	128/9376	1.22799664710813	GMPR2/NME4/RRM2B/PDE4B/HDDC2/IMPDH1/NME3/AK3/ADSL/LACC1/PRPS2/PDE7A/PDE4A/AMPD3/PDE6G/AMPD2/HDDC3/GMPR/NUDT9/PDE6D	0.991651604928141
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/1193	51/9376	1.3869138602633	PLD3/PLA2G7/CHPT1/PAFAH1B2/TMEM86A/PLD2/CEPT1/PLD1/PLA2G4C	1.05785109470276
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	6/1193	31/9376	1.52113133061136	ALDH2/GUSB/AKR1A1/HSD17B14/ALDH9A1/ALDH3A2	1.1096549693919
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1193	38/9376	1.44774341553801	BST1/SIRT7/SIRT2/CD38/NAMPT/NADSYN1/NMNAT1	1.05595073262738
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	16/1193	101/9376	1.24501838281062	VEGFB/STAT1/FN1/BAX/STAT5A/TGFBR2/PRKCD/SERPINE1/NFKB1/MAPK14/PIK3R1/CDKN1B/VEGFA/CASP3/PLCG2/PIK3CA	0.945261525244891
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/1193	80/9376	1.27711651299246	BAX/HGF/EIF4EBP1/JAK1/FOXO3/GRB2/PIK3R1/SOS1/VEGFA/BCL2L11/BCL2L1/PLCG2/PIK3CA	0.9504054673423
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/1193	88/9376	1.25032385887373	CFD/PLAUR/ITGB2/SERPINA1/C5AR1/C2/ITGAX/SERPING1/CD59/CD46/SERPINE1/C1QC/SERPINE2/PROC	0.900807642756474
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1193	46/9376	1.36681365938992	FTL/FTH1/GUSB/BLVRA/ALAS1/UROD/HCCS/ALAD	0.952210964452802
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	52/1193	368/9376	1.11053609825431	GPX1/NUP214/CAT/BAX/NDUFB5/SDHD/SDHB/UQCRB/SQSTM1/CASP1/UQCRC2/CHCHD10/NDUFB9/RANBP2/DCTN2/PINK1/ANXA11/SDHC/COX7A2L/RB1CC1/CYCS/RAB8A/DERL1/ANG/C9orf72/NRBF2/ATF6/MAPK14/DCTN3/NDUFS3/WIPI1/NDUFA8/PSMC2/FIG4/SPG11/ERN1/ACTR1A/NDUFS8/BECN1/WDR41/CASP3/TBK1/BCL2L1/ATG14/COX7C/MAP1LC3A/PIK3C3/COX6A1/DCTN1/OPTN/MCU/GLE1	0.825968406287583
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/1193	67/9376	1.29031289487183	ALDH2/FBP1/AKR1A1/PCK2/ADPGK/ALDH9A1/ALDH3A2/ALDH3B1/DLD/HK3/ACSS2	0.910545803256051
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	18/1193	117/9376	1.20910439099878	TFPT/RSF1/BPTF/MEAF6/MBD2/BCL7C/PBRM1/ARID1B/YY1/SMARCC2/BCL7B/INO80/YEATS4/SMARCD1/SRCAP/INO80D/EP400/MRGBP	0.869007702714606
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1193	20/9376	1.57183570829841	NPL/CYB5R4/UAP1L1/UAP1	0.977441438887398
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/1193	76/9376	1.24092292760401	BAX/GRB2/PIK3R1/GADD45B/GADD45G/CDKN1A/DDB2/SOS1/BAK1/E2F3/PLCG2/PIK3CA	0.805180110099736
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/1193	69/9376	1.25291252110743	ALOX5/BTK/FCER1G/MAPK14/GRB2/PIK3R1/ALOX5AP/SOS1/PLCG2/PIK3CA/PLA2G4C	0.805081048706171
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/1193	34/9376	1.3869138602633	DBP/PRKAG2/BHLHE40/NFIL3/PRKAG1/PRKAA1	0.862945560961834
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1193	62/9376	1.26760944217614	CAT/PRKAG2/FOXO3/PIK3R1/PRKAG1/HSPA6/PRKACA/SOD2/PIK3CA/PRKAA1	0.807195524259796
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1193	41/9376	1.34181097049864	TYMP/DAPK1/MMP9/HBEGF/CDKN1A/VEGFA/E2F3	0.837472102742632
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1193	21/9376	1.49698638885563	CSGALNACT2/CHST11/CHST12/CHST13	0.870526168160548
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/1193	63/9376	1.24748865737969	ALDH2/HADHA/ACAT1/SETDB2/ALDH9A1/ALDH3A2/KMT2A/DLD/KMT2B/PHYKPL	0.752541331223876
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/1193	63/9376	1.24748865737969	POLD4/ERCC1/CCNH/XPC/GTF2H5/POLR2G/DDB2/XPA/GTF2H1/ERCC4	0.752541331223876
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	43/1193	308/9376	1.09722297819532	GPX1/BAX/NDUFB5/SDHD/SDHB/UQCRB/UQCRC2/NDUFB9/PPIF/SLC25A5/DCTN2/SDHC/COX7A2L/RB1CC1/ITPR1/CYCS/SLC1A3/NRBF2/DCTN3/NDUFS3/WIPI1/NDUFA8/REST/PSMC2/POLR2G/ERN1/CREBBP/ACTR1A/AP2A1/RCOR1/NDUFS8/BECN1/AP2S1/AP2M1/CASP3/SOD2/CASP8/ATG14/COX7C/PIK3C3/COX6A1/DCTN1/CREB5	0.662427124855684
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1193	28/9376	1.40342473955215	CBR1/PCBD1/MOCS2/QDPR/FPGS	0.816266128530937
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/1193	122/9376	1.15955093235128	STAT1/CSH1/GNAI2/CSH2/STAT5A/ITPR1/MAPK14/GRB2/PIK3R1/JUNB/CREBBP/SOCS3/SOS1/PRKACA/PLCG2/SOCS1/CREB5/PIK3CA	0.677273524152565
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/1193	100/9376	1.17887678122381	CXCR4/IL18/CXCL2/TNFRSF14/CCL18/IL10RB/CXCL3/CCL20/TNFSF10/IL10RA/LTBR/IL2RG/CXCL9/CCL5/IL10	0.686630650329034
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	14/1193	93/9376	1.18310214603106	TGFBR2/WAS/RAP1A/SMURF2/PDCD10/CSNK2A2/CCM2/RAP1B/PTPN1/RHOA/CSNK2B/CREBBP/CSNK2A1/MAP3K7	0.677548390458378
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/1193	86/9376	1.18801536092321	NCK1/STAT5A/EREG/EIF4EBP1/HBEGF/GRB2/PIK3R1/AREG/CDKN1A/SOS1/CDKN1B/PLCG2/PIK3CA	0.668781553538115
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/1193	138/9376	1.13901138282493	FBP1/RHOQ/PPP1CC/PCK2/PRKAR1A/PRKAG2/EIF4EBP1/GRB2/PIK3R1/PHKG2/PTPN1/SOCS3/PRKAG1/SOS1/PYGB/PRKACA/HK3/SOCS1/PIK3CA/PRKAA1	0.628131411709825
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1193	36/9376	1.30986309024867	GUSB/AKR1A1/CRYL1/FGGY/SORD/DHDH	0.711209001137842
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1193	36/9376	1.30986309024867	GALNT7/GALNT6/ST6GALNAC4/GALNT11/B4GALT5/GCNT1	0.711209001137842
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	65/1193	480/9376	1.06426376082705	GPX1/CAT/BAX/NDUFB5/SDHD/UBE2L6/SDHB/UQCRB/SQSTM1/UQCRC2/PRNP/NDUFB9/PPIF/SLC25A5/SNCA/DCTN2/PINK1/SDHC/COX7A2L/RB1CC1/ITPR1/CYCS/RAB8A/DERL1/C9orf72/NFKB1/NRBF2/ATF6/CSNK2A2/MAPK14/DCTN3/NDUFS3/WIPI1/NDUFA8/LRRK2/ATXN1/PSMC2/FIG4/SPG11/CSNK2B/ERN1/ACTR1A/PSEN1/NDUFS8/BECN1/CDK5/CSNK2A1/WDR41/CASP3/TBK1/CAPN2/CASP8/BCL2L1/BAK1/ATG14/COX7C/MAP1LC3A/PIK3C3/COX6A1/DCTN1/FRAT1/FAS/CASP7/OPTN/MCU	0.551872754254908
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/1193	73/9376	1.18425978022483	BAX/HGF/MITF/PIK3R1/GADD45B/GADD45G/CDKN1A/DDB2/BAK1/E2F3/PIK3CA	0.603434383981613
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	33/1193	238/9376	1.08971803306402	VEGFB/GNB4/RRAS/RALA/HGF/MRAS/RASGRP3/RAP1A/RASAL2/NFKB1/RAB5C/GRB2/PIK3R1/TIAM1/RAP1B/REL/RHOA/RALGDS/PLD2/SOS1/RAB5B/RASSF5/VEGFA/PLD1/TBK1/PRKACA/BCL2L1/GNGT2/RALGAPA1/PLCG2/IKBKG/PIK3CA/PLA2G4C	0.535293820501323
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1193	23/9376	1.36681365938992	CTSA/ATP6AP2/PRCP/ANPEP	0.672486444893618
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1193	23/9376	1.36681365938992	PCK2/ATP1B3/ATP1B1/MDH1	0.672486444893618
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1193	60/9376	1.17887678122381	MAPKAPK3/MAPK14/PIK3R1/VEGFA/HSPB1/SPHK1/PLCG2/PIK3CA/PLA2G4C	0.530718762026267
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1193	53/9376	1.18629110060257	ATP2B1/ATP1B3/ATP1B1/AP2A1/AP2S1/AP2M1/PRKACA/VDR	0.519280226612781
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1193	17/9376	1.3869138602633	TXNRD1/SEPHS2/TXNRD2	0.609640217087893
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1193	61/9376	1.15955093235128	FTL/FTH1/ATOX1/SLC31A1/ATP2B1/CYBRD1/ATP1B3/ATP1B1/VDR	0.47733405375342
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/1193	99/9376	1.11139898566554	BAX/NOTCH2/NCOR1/MMP9/HBEGF/MAPK14/GRB2/PIK3R1/CDKN1A/SOS1/CDKN1B/PRKACA/E2F3/PIK3CA	0.425446191076002
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/1193	99/9376	1.11139898566554	GPCPD1/WAS/EIF4EBP1/HIF1A/CHPT1/GRB2/PIK3R1/RALGDS/PLD2/SOS1/PIP5K1C/PLD1/PIK3CA/PLA2G4C	0.425446191076002
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/1193	54/9376	1.16432274688771	SDS/SDSL/SMS/APIP/IL4I1/LACC1/AHCY/MDH1	0.462369950247853
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	37/1193	275/9376	1.05741674921893	NCF2/CYBA/BAX/NDUFB5/SDHD/SDHB/UQCRB/UQCRC2/PRNP/NDUFB9/PPIF/SLC25A5/PRKCD/SDHC/COX7A2L/ITPR1/CYCS/NCF1/CSNK2A2/MAPK14/PIK3R1/NDUFS3/NDUFA8/C1QC/PSMC2/CSNK2B/CCL5/NDUFS8/CSNK2A1/HSPA6/CASP3/PRKACA/COX7C/COX6A1/CREB5/PIK3CA/MCU	0.368986072988273
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1193	18/9376	1.30986309024867	ACSL3/ACSL1/OXSM	0.502416813022998
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/1193	78/9376	1.10834569174888	FIG4/ITPK1/PIP5K1C/PIK3C3/SACM1L/MTMR3/IMPA1/PLCG2/INPP4A/PIK3CA/MTM1	0.366871319410677
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/1193	79/9376	1.09431599944826	GSTO1/GSTK1/MGST1/EPHX1/MGST2/CYP1B1/CBR1/ALDH3B1/GSTM4/GSTT1/DHDH	0.321423100351308
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1193	26/9376	1.20910439099878	TCN2/LMBRD1/SCARB1/BTD	0.407655781208973
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	15/1193	110/9376	1.07170616474891	TGIF1/HAMP/ID2/TGFBR2/NCOR1/SMAD7/EMP3/SMURF2/ZFYVE16/RHOA/CREBBP/TFRC/BMPR2/TMEM53/FBN1	0.288839293267364
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1193	50/9376	1.10028499580889	SAT1/ALDH2/AOC1/SAT2/SMS/ALDH9A1/ALDH3A2	0.271470624340815
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1193	27/9376	1.16432274688771	HADHA/ACAT1/ACADS/ACSM5	0.326472475865843
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1193	12/9376	1.30986309024867	COQ2/VKORC1	0.410090163853728
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1193	35/9376	1.12273979164172	FBP1/HSD17B14/PFKFB3/HK3/SORD	0.277761662104783
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1193	43/9376	1.09662956392912	CD36/AGPAT2/ACAT1/SLC27A1/SCARB1/DGAT1	0.242484062236037
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	31/1193	238/9376	1.02367451590863	CFD/STAT1/C5AR1/C2/CASP1/OAS1/NFKBIA/IFIH1/STAT2/JAK1/ADAM17/HBEGF/IFNAR1/MX1/TLR8/OAS2/NFKB1/MAPK14/TLR4/PIK3R1/IFNAR2/C1QC/TRAF3/TLR7/IRAK4/TBK1/MYD88/MAP3K7/PLCG2/IKBKG/PIK3CA	0.141251670778437
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/1193	20/9376	1.17887678122381	LIPA/SOAT1/SC5D	0.3057549150668
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/1193	98/9376	1.04254409223874	ITPR1/PIK3R1/ITPK1/CDS2/PIP5K1C/PIK3C3/SACM1L/MTMR3/IMPA1/PLCG2/INPP4A/PIK3CA/MTM1	0.161649624372646
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1193	59/9376	1.06565132765994	MGLL/GNAI2/PIK3R1/PNPLA2/ABHD5/PRKACA/FABP4/PIK3CA	0.19314392633318
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/1193	106/9376	1.03800471302725	NFKBIA/MMP9/NFKB1/GRB2/PIK3R1/SPINT1/CDKN1A/CREBBP/SOS1/CDKN1B/E2F3/IKBKG/CREB5/PIK3CA	0.150245027503528
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	17/1193	130/9376	1.02773873234896	VEGFB/GNB4/GNAI2/ARRB2/TGFBR2/NFKBIA/MMP9/NFKB1/MAPK14/GRB2/PIK3R1/SOS1/VEGFA/PRKACA/GNGT2/CREB5/PIK3CA	0.121599258349577
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/1193	83/9376	1.04157787899292	UBE2D1/PCGF5/MAX/UBE2D3/CSNK2B/CREBBP/YY1/KDM2A/FOXK2/L3MBTL4/UBE2D4	0.145269015406413
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	30/1193	232/9376	1.0162730872619	TMSB4X/CXCR4/ITGB2/FN1/ITGAX/RGCC/RRAS/MRAS/GNA13/PPP1CC/IQGAP2/ITGAL/ITGA6/LIMK1/ARPC1B/ITGAE/ARPC3/SPATA13/ARPC4/PIK3R1/TIAM1/RHOA/BRK1/GSN/SOS1/PIP5K1C/SSH1/ARPC5/ITGAD/PIK3CA	0.0958286613583715
NA	NA	hsa04518	Integrin signaling	20/1193	154/9376	1.02067253785611	ITGB2/VEGFB/FN1/ITGAX/PARVG/FERMT3/LIMS1/HGF/ITGAL/ITGA6/TLN1/ITGAE/PIK3R1/FLNA/VEGFA/ICAM2/ITGAD/PIK3CA/THBS3/FBN1	0.0987622969269324
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1193	139/9376	1.01773535069681	CTSD/GNAI2/MMP9/PRKCD/HBEGF/ITPR1/GRB2/PIK3R1/EBAG9/NCOA1/SOS1/HSPA6/PRKACA/POMC/RARA/CREB5/PIK3CA/KCNJ5	0.0804324492003748
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1193	37/9376	1.06205115425568	GLUL/IL4I1/ADSL/ASRGL1/ASL	0.144394324471875
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1193	37/9376	1.06205115425568	IL4I1/FAH/ALDH3B1/GSTZ1/COMT	0.144394324471875
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1193	37/9376	1.06205115425568	IL18/IL10/MYD88/APOL1/FAS	0.144394324471875
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	38/1193	298/9376	1.002177129452	CXCR4/TNFSF13B/IL18/CXCL16/CXCL2/CSH1/TNFRSF14/CCL18/CSF3R/TNFSF12/OSM/IL10RB/CXCL3/CCL20/IFNGR1/CSH2/TGFBR2/TNFSF10/IL10RA/LTBR/IL1RN/IFNGR2/IFNAR1/IL2RG/CD40/CXCL9/IFNAR2/CCL5/IL7R/CD4/BMPR2/IL10/IL27RA/IL15/IL32/IL15RA/FAS/TNFSF9	0.0145830001485451
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1193	93/9376	1.01408755374091	MAP3K2/PRKCD/HBEGF/ITPR1/MAPK14/GRB2/PTK2B/PLD2/SOS1/PLD1/PRKACA/PLA2G4C	0.0521293691502065
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	34/1193	268/9376	0.997059964219139	DUSP1/BAX/NDUFB5/SDHD/UBE2L6/SDHB/UQCRB/GNAI2/UQCRC2/NDUFB9/PPIF/SLC25A5/SNCA/NFE2L2/PINK1/SLC39A11/SDHC/COX7A2L/ITPR1/CYCS/ATF6/SLC39A3/NDUFS3/NDUFA8/LRRK2/PSMC2/ERN1/NDUFS8/CASP3/PRKACA/BCL2L1/COX7C/COX6A1/MCU	-0.0186448153385004
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1193	70/9376	1.01046581247755	GSTO1/GSTK1/MGST1/EPHX1/MGST2/CYP1B1/CBR1/GSTM4/GSTT1	0.0335575332601201
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1193	38/9376	1.03410243967	SGK1/ATP1B3/PIK3R1/ATP1B1/PIK3CA	0.0804266347739647
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1193	30/9376	1.04789047219894	ABCC3/NFKB1/FPGS/IKBKG	0.100310510969393
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	18/1193	143/9376	0.989267228998998	HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DRA/FCGR3A/HLA-DPB1/HLA-DPA1/C2/HLA-DOA/HLA-DQA1/CD86/HLA-DQB1/FCGR1A/HLA-DRB1/CD40/C1QC/IL10/TRIM21	-0.0493807917074926
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1193	63/9376	0.997990925903751	LTA4H/ALOX5/GPX4/TBXAS1/CBR1/PTGES2/ALOX15B/PLA2G4C	-0.00610901247324383
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1193	47/9376	1.00329938827558	PRKCD/PIK3R1/SOCS3/HK3/SOCS1/PIK3CA	0.00865793644888387
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1193	23/9376	1.02511024454244	POLD4/MSH3/MLH3	0.0460350879812919
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/1193	56/9376	0.982397317686505	MGAT1/SRD5A3/MAN1A1/MGAT4B/ALG13/MAN1B1/MAN2A2	-0.0504445779526454
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1193	32/9376	0.982397317686505	GAA/GLA/GLB1/HK3	-0.0380835136039556
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/1193	107/9376	0.954853467657911	FBP1/PCK2/SIK1/PRKAG2/ITPR1/CPT1A/PHKG2/CREBBP/PRKAG1/PYGB/PRKACA/CREB5/PRKAA1	-0.179328547324615
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1193	33/9376	0.952627701999035	DLD/IDH3B/ACO1/CS	-0.10408492474838
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/1193	140/9376	0.954328822895462	GNB4/RRAS/GNAI2/MRAS/GNA13/PRKAG2/SERPINE1/ITPR1/PIK3R5/BECN1/PRKAG1/PRKACA/GNGT2/MAP1LC3A/PIK3C3/SPHK1/PRKAA1	-0.207880544256957
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1193	16/9376	0.982397317686505	IL4I1/ALDH3B1	-0.0269060845423618
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/1193	75/9376	0.943101424979044	SDS/TKT/GLUL/SDSL/PRPS2/IDH3B/ACO1/CS/ASL	-0.188893400061558
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1193	67/9376	0.938409378088601	PPP1CC/RAP1A/ITPR1/RPS6KA1/RAP1B/CREBBP/PRKACA/RPS6KA2	-0.193174617083798
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/1193	34/9376	0.924609240175534	POLR3GL/POLR2G/CRCP/POLR3C	-0.168146267708761
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1193	68/9376	0.924609240175534	ALDH1A1/DHRS4L2/DHRS3/RDH11/DHRS9/DHRS4/DGAT1/PNPLA4	-0.238228641321813
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1193	26/9376	0.906828293249081	ACAA1/ACOX1/PLA2G4C	-0.181641259280594
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/1193	217/9376	0.9416527284737	GSTO1/MGST1/NOTCH2/EPHX1/MGST2/GNAI2/ARRB2/STAT5A/CYP1B1/EIF4EBP1/BCL6/RPS6KA1/NFKB1/GRB2/PIK3R1/SOS1/MIR29A/VEGFA/PRKACA/GSTM4/VDR/GSTT1/RPS6KA2/CREB5/PIK3CA/PAQR8	-0.332028966776682
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1193	52/9376	0.906828293249081	ALOX5/CYP1B1/SCARB1/ACOT2/PRKACA/PLA2G4C	-0.257237437675995
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	17/1193	144/9376	0.927819688926143	PPIF/SLC25A5/RB1CC1/ITPR1/CYCS/NRBF2/PIK3R1/WIPI1/ATXN1/PSMC2/ERN1/BECN1/OMA1/ATG14/PIK3C3/PIK3CA/MCU	-0.333274190316117
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/1193	78/9376	0.906828293249081	FN1/RHOG/ARPC1B/ARPC3/ARPC4/PIK3R1/RHOA/ARPC5/PIK3CA	-0.315490412546178
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1193	36/9376	0.873242060165782	GAA/GYG1/PYGB/HK3	-0.2909394200627
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	25/1193	212/9376	0.926789922345759	ITGB2/VEGFB/APBB1IP/RRAS/RALA/GNAI2/HGF/MRAS/RASGRP3/RAP1A/ITGAL/TLN1/MAPK14/PIK3R1/TIAM1/RAP1B/SIPA1/FPR1/RHOA/RALGDS/RASSF5/VEGFA/RAPGEF2/SIPA1L1/PIK3CA	-0.411666798697774
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	14/1193	122/9376	0.901872947384332	STAT1/NOTCH2/NCOR1/HIF1A/ATP1B3/SLC16A10/PIK3R1/ATP1B1/CREBBP/NCOA1/PRKACA/THRA/PLCG2/PIK3CA	-0.416536924982643
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/1193	37/9376	0.849640923404545	NAGK/HK3/UAP1L1/UAP1	-0.349888693508519
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/1193	89/9376	0.88305376870697	GLUL/GABARAPL1/GNB4/GABARAP/GNAI2/GABARAPL2/NSF/PRKACA/GNGT2/TRAK2	-0.423246227478806
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	43/1193	362/9376	0.933548832276678	VEGFB/CSH1/FN1/GNB4/CSF3R/OSM/HGF/CSH2/PKN1/SGK3/EREG/PCK2/SGK1/EIF4EBP1/JAK1/IFNAR1/ITGA6/FOXO3/IL2RG/NFKB1/PPP2R5E/GRB2/TLR4/PIK3R1/DDIT4/IFNAR2/PIK3R5/AREG/PKN2/CDKN1A/IL7R/PPP2R5A/SOS1/CDKN1B/VEGFA/BCL2L11/BCL2L1/GNGT2/IKBKG/CREB5/PIK3CA/THBS3/PRKAA1	-0.492320261857807
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/1193	46/9376	0.8542585371187	PSMB9/PSMB8/PSMB10/PSMC2/PSME2	-0.378330019557551
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/1193	99/9376	0.873242060165782	PPP1CC/PTGER4/PRKCD/ITPR1/MAPK14/PIK3R1/TRPV2/PRKACA/PLCG2/PIK3CA/PLA2G4C	-0.484103893486268
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1193	29/9376	0.813018469809521	RASSF4/RASSF2/LATS2	-0.385044719292241
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/1193	91/9376	0.863645993570553	GNB4/GNAI2/ARRB2/PDE4B/PDE7A/PDE4A/PRKACA/GNGT2/GRK6/KCNJ5	-0.499053642438442
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	26/1193	226/9376	0.904153283534482	RRAS/ATP2B1/GNAI2/PPP1CC/RAP1A/NFKBIA/ATP1B3/NFKB1/PDE4B/PIK3R1/TIAM1/RAP1B/ATP1B1/HCAR3/RHOA/HCAR2/CREBBP/PLD2/PDE4A/PLD1/SUCNR1/ACOX1/PRKACA/POMC/CREB5/PIK3CA	-0.556891380927855
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1193	48/9376	0.818664431405421	ATP1B3/PIK3R1/ATP1B1/HK3/PIK3CA	-0.480904601754101
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/1193	75/9376	0.838312377759151	GPX1/ASGR1/ITPR1/ATP1B3/ATP1B1/PRKACA/TTF1/CREB5	-0.536774861263125
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1193	93/9376	0.845072961450757	LYZ/BST1/ATP2B1/ITPR1/ATP1B3/ATP1B1/KCNMA1/CD38/CAMP/PRKACA	-0.573289652157965
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/1193	170/9376	0.878378778166757	RAB13/WAS/RAP1A/PRKAG2/RAB8A/ARPC1B/ARPC3/ARPC4/TIAM1/ARHGEF2/RHOA/YBX3/CD1D/PRKAG1/PRKACA/RAPGEF2/ARPC5/CLDN23/PRKAA1	-0.611009442668233
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1193	49/9376	0.8019569940298	GNAI2/NFKB1/CDK5/PRKACA/CREB5	-0.53068418539789
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/1193	102/9376	0.847558470160906	BST1/ATP2B1/RAP1A/ITPR1/RAB8A/ATP1B3/RAP1B/ATP1B1/KCNMA1/RHOA/CD38	-0.591043469412418
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/1193	154/9376	0.867571657177692	RGS2/GNAI2/PPP1CC/PRKAG2/ITPR1/CACNA2D4/PIK3R5/RHOA/CDKN1A/NFATC3/PRKAG1/KCNJ2/CD38/PRKACA/PRKAA1/KCNJ5/PLA2G4C	-0.632671586159101
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1193	41/9376	0.766749125999223	SDS/SDSL/ALAS1/DLD	-0.571488678760135
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1193	69/9376	0.797307967977453	CTSB/GNAI2/PTGER4/ITPR1/KCNMA1/KCNJ2/PRKACA	-0.645217219734977
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/1193	78/9376	0.806069593999183	BTG1/PABPC4/EXOSC1/C1D/CNOT6L/PABPC1/ZCCHC7/XRN1	-0.656671278524605
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1193	23/9376	0.68340682969496	GLUL/ASL	-0.580416268931034
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1193	23/9376	0.68340682969496	ACAT1/PCYOX1	-0.580416268931034
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/1193	71/9376	0.774848588597806	HIF1A/PIK3R1/SCO2/G6PD/SLC16A3/HK3/PIK3CA	-0.727101840276773
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/1193	44/9376	0.714470776499276	POLD4/MBD4/MPG/PARP4	-0.724834943264611
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1193	24/9376	0.654931545124336	HS3ST1/HS2ST1	-0.64626139753233
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1193	63/9376	0.748493194427813	BAX/GADD45B/GADD45G/CDKN1A/DDB2/BAK1	-0.764759356170363
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1193	73/9376	0.753619860143072	GSTO1/GSTK1/MGST1/MGST2/ALDH3B1/GSTM4/GSTT1	-0.806873034030877
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1193	45/9376	0.698593648132625	ABCC3/TAP1/ABCB7/ABCG1	-0.773827477909214
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1193	65/9376	0.725462634599265	NCEH1/ITPR1/SCARB1/PRKACA/POMC/CREB5	-0.84802676820438
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1193	14/9376	0.56136989582086	B3GNT2	-0.627086886310301
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/1193	56/9376	0.701712369776075	ARRB2/SMURF2/SPOP/SPOPL/PRKACA	-0.854812542041088
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/1193	148/9376	0.796538365691761	BAX/NOTCH2/GRB2/PIK3R1/GADD45B/GADD45G/CDKN1A/NCOA1/DDB2/SOS1/NFKB2/BAK1/E2F3/PIK3CA/FRAT1	-0.952596930712498
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1193	66/9376	0.714470776499276	HSD17B11/SRD5A3/CYP1B1/DHRS9/SRD5A1/COMT	-0.888786145170372
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/1193	150/9376	0.785917854149204	BAX/HGF/TGFBR2/GRB2/PIK3R1/GADD45B/GADD45G/CDKN1A/DDB2/SOS1/CDKN1B/BAK1/E2F3/PIK3CA/FRAT1	-1.00918070418921
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/1193	203/9376	0.813018469809521	VEGFB/FN1/ZYX/PARVG/HGF/PPP1CC/RAP1A/BIRC3/ITGA6/TLN1/GRB2/PIK3R1/RAP1B/RHOA/FLNA/SOS1/PIP5K1C/VEGFA/CAPN2/PIK3CA/THBS3	-1.02834920397196
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/1193	87/9376	0.72268308427513	UQCRB/UQCRC2/COX7A2L/ATP1B3/CACNA2D4/ATP1B1/COX7C/COX6A1	-0.992204267723853
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	13/1193	133/9376	0.768190383754861	GNB4/GNAI2/ARRB2/PPP1CC/ITPR1/PPP2R5E/MAPK14/PPP2R5A/PRKACA/GNGT2/CREB5/COMT/KCNJ5	-1.02801718913498
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/1193	115/9376	0.751747512664456	DUSP1/ALOX5/GNB4/GNAI2/ITPR1/CASP3/PRKACA/ALOX15B/GNGT2/KCNJ5/PLA2G4C	-1.02273512353972
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1193	49/9376	0.64156559522384	GALNT7/GALNT6/GALNT11/LFNG	-0.960475575420401
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/1193	116/9376	0.745266930658728	GLUL/GNB4/HOMER3/GNAI2/ITPR1/SLC1A3/PLD2/PLD1/PRKACA/GNGT2/PLA2G4C	-1.0540432083864
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/1193	98/9376	0.72176129462682	ATP2B1/ITPR1/ATP1B3/SCARB1/ATP1B1/PRKACA/POMC/CREB5/KCNJ5	-1.05718984335387
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/1193	108/9376	0.727701716804818	NUP214/RANBP2/SUMO3/TNPO1/NMD3/PHAX/SUMO2/DDX19B/EIF4A3/GLE1	-1.08670922259364
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1193	90/9376	0.698593648132625	ABCC3/NCEH1/EPHX1/AQP9/ATP1B3/SCARB1/ATP1B1/PRKACA	-1.09700573986814
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1193	17/9376	0.462304620087767	GLUL	-0.84721888203689
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	18/1193	184/9376	0.76883268340683	CXCR4/RRAS/PLXNC1/GNAI2/NCK1/LIMK1/DPYSL2/PIK3R1/RHOA/SEMA4A/EPHB6/CDK5/BMPR2/NFATC3/SSH1/SEMA3C/PLCG2/PIK3CA	-1.20914927503743
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/1193	166/9376	0.757511184722124	RGS2/ATP2B1/GNAI2/GNA13/PPIF/SLC25A5/PPP1CC/ITPR1/ATP1B3/ATP1B1/KCNMA1/PIK3R5/RHOA/GTF2I/NFATC3/CREB5	-1.20355384613566
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	14/1193	149/9376	0.738446305912004	MGLL/GNB4/NDUFB5/GNAI2/NDUFB9/ITPR1/MAPK14/NDUFS3/NDUFA8/NDUFS8/PRKACA/GNGT2/ABHD6/KCNJ5	-1.22877768709
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1193	31/9376	0.507043776870454	OXA1L/SEC63	-1.04966117091183
NA	NA	hsa04981	Folate transport and metabolism	2/1193	31/9376	0.507043776870454	ABCC3/FPGS	-1.04966117091183
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/1193	103/9376	0.686724338576974	PABPC4/PPP1CC/PPP2R5E/PABPC1/PPP2R5A/DDX19B/EIF4A3/GSPT2/GLE1	-1.22063191932171
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1193	103/9376	0.686724338576974	SLC7A7/KCNE3/PRCP/ATP1B3/SLC16A10/SLC3A2/ATP1B1/SLC36A4/SLC36A1	-1.22063191932171
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1193	19/9376	0.413640975868002	DLD	-0.976836060695443
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1193	54/9376	0.582161373443855	ERCC1/REV3L/ERCC4/WDR48	-1.17571078034873
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/1193	65/9376	0.604552195499388	ARRB2/ITPR1/PIK3R1/PIK3CA/KCNJ5	-1.2215106790825
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/1193	115/9376	0.68340682969496	GNB4/GNAI2/ITPR1/PIK3R1/PIK3R5/KCNJ2/PRKACA/GNGT2/CREB5/PIK3CA	-1.30428080950549
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/1193	76/9376	0.620461463802003	GNAI2/ITPR1/ATP1B3/ATP1B1/KCNJ2/PRKACA	-1.26844249902729
NA	NA	hsa04517	IgSF CAM signaling	30/1193	299/9376	0.788546341955723	CD48/ITGB2/ITGAX/CADM1/CD84/MBP/PMP22/CD86/NCK1/DOK1/RAP1A/ITGAL/SLAMF7/ARPC1B/NRP2/TRIO/MAPK14/ARPC3/GRB2/ARPC4/PIK3R1/RAP1B/PPFIA1/CRTAM/RHOA/ICAM2/RAPGEF2/ARPC5/PLCG2/PIK3CA	-1.41882624564981
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/1193	99/9376	0.635085134666023	LMNA/PRKAG2/ITGA6/CACNA2D4/SNTB1/PRKAG1/SNTB2/PRKAA1	-1.39365397804854
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/1193	110/9376	0.643023698849349	GNAI2/ANAPC13/RPS6KA1/MAPK14/PIK3R1/PRKACA/RPS6KA2/ANAPC7/PIK3CA	-1.43793470057417
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	32/1193	323/9376	0.778618307516239	VIM/CD44/ST14/MARCKS/NOTCH2/DICER1/TIMP3/CYP1B1/FOXP1/MMP9/NFKB1/ZEB2/GRB2/BMF/PIK3R1/DDIT4/RHOA/CDKN1A/CREBBP/BMPR2/CCNG1/SOS1/MIR29A/CDKN1B/VEGFA/CASP3/BCL2L11/BAK1/E2F3/PLCG2/SOCS1/PIK3CA	-1.54595300851537
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/1193	36/9376	0.436621030082891	POLD4/RNASEH2B	-1.29308784126324
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/1193	60/9376	0.523945236099469	GNAI2/GNA13/ITPR1/PLA2G4C	-1.4124314694476
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/1193	154/9376	0.663437149606471	ATP2B1/GNAI2/PPP1CC/ATP1B3/PPP2R5E/CACNA2D4/MAPK14/ATP1B1/PIK3R5/PPP2R5A/KCNE1/PRKACA/CREB5	-1.60791676360714
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/1193	155/9376	0.65915690993159	NCEH1/GNAI2/RAP1A/ITPR1/KMT2A/SCARB1/RAP1B/CDKN1A/CDKN1B/PRKACA/POMC/E2F3/CREB5	-1.63373237914211
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/1193	39/9376	0.403034796999592	AHCY/DLD	-1.42635367518989
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/1193	41/9376	0.383374562999612	POLD4/NBN	-1.51079586642865
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/1193	254/9376	0.711657899426444	CXCR4/VEGFB/ORAI3/ATP2B1/HGF/ORAI2/PPIF/SLC25A5/MCOLN1/P2RX7/ITPR1/TFEB/PTAFR/P2RX4/PHKG2/PTK2B/NFATC3/CD38/VEGFA/PRKACA/SPHK1/PLCG2/MCU	-1.77880960884823
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/1193	89/9376	0.529832261224182	CD44/CD36/FN1/ITGA6/CD47/THBS3	-1.70160867536196
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/1193	89/9376	0.529832261224182	MAP3K2/GNAI2/ITPR1/GRB2/SOS1/PRKACA	-1.70160867536196
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1193	28/9376	0.28068494791043	B3GNT2	-1.45542019414822
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1193	29/9376	0.271006156603174	PDE6G	-1.50119228091971
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1193	30/9376	0.261972618049735	PLA2G4C	-1.545858714554
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/1193	138/9376	0.569505691412466	PPP1CC/ANAPC13/ITPR1/RPS6KA1/PPP2R5E/MAPK14/PPP2R5A/PRKACA/RPS6KA2/ANAPC7	-1.94521478954479
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/1193	97/9376	0.486134755143837	GNB4/GNAI2/ITPR1/PRKACA/GNGT2/KCNJ5	-1.94237960579412
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/1193	86/9376	0.456928984970467	ATP1B3/ATP1B1/KCNMA1/PRKACA/CREB5	-1.93173512701071
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/1193	86/9376	0.456928984970467	LMNA/ITGA6/CACNA2D4/SNTB1/SNTB2	-1.93173512701071
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/1193	233/9376	0.640877220121668	VIM/FMNL2/FN1/ZYX/SDC2/LMNA/PDLIM7/FHL3/SDC3/ITGA6/TLN1/ATP1B3/ATP1B1/SNTB1/SNTB2/AMPD3/AMPD2/THBS3/FBN1	-2.11946446340965
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/1193	134/9376	0.527855275174838	GNA13/PPP1CC/PRKCD/ITPR1/KCNMA1/RHOA/PRKACA/ARHGEF11/PLA2G4C	-2.10181333599031
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/1193	101/9376	0.466881893553982	GNAI2/MITF/CREBBP/PRKACA/POMC/ASIP	-2.05672745307577
NA	NA	hsa04382	Cornified envelope formation	17/1193	217/9376	0.615696014771265	ST14/S100A10/S100A6/S100A4/S100A8/DST/S100A9/SLC27A1/PADI2/ITGA6/PPP2R5E/UGCG/ELOVL1/PPP2R5A/ABHD5/S100A11/CLDN23	-2.18690697620955
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/1193	178/9376	0.573984949659531	SERPINF1/TLE3/CSNK2A2/CTNNBIP1/RHOA/CSNK2B/CREBBP/PSEN1/CSNK2A1/NFATC3/PRKACA/MAP3K7/FRAT1	-2.19097703359439
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/1193	158/9376	0.547157999724129	ANAPC13/CCNH/PPP2R5E/GADD45B/GADD45G/CDKN1A/CREBBP/PPP2R5A/CDKN1B/E2F3/ANAPC7	-2.19182802766579
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/1193	105/9376	0.449095916656688	LMNA/ITGA6/CACNA2D4/SNTB1/PRKACA/SNTB2	-2.16748916341137
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/1193	69/9376	0.34170341484748	PPP1CC/PRKACA/CREB5	-2.09551548817613
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/1193	144/9376	0.491198658843252	ID2/PCGF5/JAK1/MAPK14/GRB2/PIK3R1/REST/BMPR2/PIK3CA	-2.34926051831864
NA	NA	hsa04081	Hormone signaling	16/1193	219/9376	0.574186560109007	HAMP/CSH1/GNB4/GNAI2/GNA13/CSH2/STAT5A/SLC16A10/PIK3R1/RHOA/ADIPOR1/PRKACA/POMC/THRA/GNGT2/PIK3CA	-2.43452590262391
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/1193	157/9376	0.5005846204772	ITGB2/ID2/TGFBR2/PPP1CC/SMAD7/BIRC3/SERPINE1/AREG/BMPR2/LATS2	-2.40945830582176
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/1193	191/9376	0.452622847939332	GNB4/GNAI2/SLC29A3/PPP1CC/GRB2/SOS1/PRKACA/GNGT2/SLC29A1/CREB5/HDAC10	-2.91818857903158
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/1193	194/9376	0.445623525548518	MYO9B/MYO1F/DCTN2/MYO1E/DYNC1LI1/DCTN3/HOOK3/KIF13B/ACTR1A/KIF13A/DCTN1	-2.97911039884978
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1193	86/9376	0.182771593988187	PKD2L1/PRKACA	-2.90692888221653
Genetic Information Processing	Transcription	hsa03040	Spliceosome	13/1193	243/9376	0.420449880820562	SYF2/PQBP1/BCAS2/CDC40/SLU7/SMNDC1/SF3B2/U2AF1L4/HSPA6/ISY1/EIF4A3/SART1/XAB2	-3.49491801118761
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/1193	183/9376	0.343570646622603	POP4/CSNK2A2/NOP10/CSNK2B/NMD3/CSNK2A1/XRN1/RPP38	-3.42400580499448
NA	NA	hsa04082	Neuroactive ligand signaling	9/1193	199/9376	0.355440235544866	GNB4/GNAI2/P2RY11/SLC1A3/P2RX4/PRKACA/POMC/GNGT2/AGRP	-3.50904508956361
NA	NA	hsa04519	Cadherin signaling	26/1193	404/9376	0.505788718016814	VIM/LHFPL2/RRAS/APH1B/PSENEN/MRAS/PPP1CC/MYO1F/NCSTN/NFKBIA/MYO1E/ARPC1B/NFKB1/MAPK14/ARPC3/ARPC4/APH1A/TAOK3/RHOA/BRK1/PTK2B/CREBBP/PSEN1/ARPC5/IKBKG/LATS2	-3.87711149159387
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/1193	370/9376	0.382338415532045	TSPO/C5AR1/CSH1/FPR3/CSH2/NR3C1/P2RY11/PTGER4/P2RX7/PTAFR/P2RX4/FPR1/GPR35/POMC/THRA/P2RY8/UTS2/S1PR4	-4.62844456297575
Genetic Information Processing	Translation	hsa03010	Ribosome	6/1193	222/9376	0.212410230851136	MRPL34/MRPL44/MRPS22/MRPL54/DAP3/MRPL10	-4.5344089273839
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1193	449/9376	0.0525112151992786	RGS2/ARRB2/PRKACA	-7.85586597555462