ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0023026 MHC class II protein complex binding 16/2150 27/18639 0.592592592592593 5.13736434108527 3.48252448993642e-09 4.29047017160167e-06 GO:0023023 MHC protein complex binding 18/2150 37/18639 0.486486486486487 4.21749842866122 2.46354908012443e-08 1.51754623335665e-05 GO:0035091 phosphatidylinositol binding 64/2150 284/18639 0.225352112676056 1.95364559449722 9.12502135826703e-08 3.56824465376811e-05 GO:0005543 phospholipid binding 97/2150 497/18639 0.195171026156942 1.69199663094848 1.15852099148315e-07 3.56824465376811e-05 GO:0042605 peptide antigen binding 18/2150 45/18639 0.4 3.46772093023256 9.61625796266953e-07 0.000212855981942329 GO:0044389 ubiquitin-like protein ligase binding 67/2150 322/18639 0.208074534161491 1.80386104290048 1.03663627569316e-06 0.000212855981942329 GO:0019003 GDP binding 23/2150 75/18639 0.306666666666667 2.65858604651163 7.10853361481168e-06 0.00125110191620686 GO:0004197 cysteine-type endopeptidase activity 25/2150 88/18639 0.284090909090909 2.46286997885835 1.29840758092146e-05 0.00182730560212887 GO:0038187 pattern recognition receptor activity 17/2150 48/18639 0.354166666666667 3.07037790697674 1.33488233921752e-05 0.00182730560212887 GO:0031625 ubiquitin protein ligase binding 60/2150 302/18639 0.198675496688742 1.72237794547975 1.66773973671239e-05 0.00205465535562966 GO:0005484 SNAP receptor activity 14/2150 36/18639 0.388888888888889 3.37139534883721 2.27011268769273e-05 0.00228803589263387 GO:0032395 MHC class II receptor activity 7/2150 10/18639 0.7 6.06851162790698 2.35282555921715e-05 0.00228803589263387 GO:0042625 ATPase-coupled ion transmembrane transporter activity 11/2150 24/18639 0.458333333333333 3.97343023255814 2.78575798616136e-05 0.00228803589263387 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 11/2150 24/18639 0.458333333333333 3.97343023255814 2.78575798616136e-05 0.00228803589263387 GO:0046961 proton-transporting ATPase activity, rotational mechanism 11/2150 24/18639 0.458333333333333 3.97343023255814 2.78575798616136e-05 0.00228803589263387 GO:0008429 phosphatidylethanolamine binding 9/2150 17/18639 0.529411764705882 4.58963064295486 3.62896426463166e-05 0.00279430248376638 GO:0043130 ubiquitin binding 26/2150 100/18639 0.26 2.25401860465116 4.79886704338495e-05 0.00347776717497074 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 47/2150 229/18639 0.205240174672489 1.77928912359094 5.74894062799435e-05 0.00393483047427169 GO:0032182 ubiquitin-like protein binding 29/2150 120/18639 0.241666666666667 2.09508139534884 7.73063624393639e-05 0.00466282142049042 GO:0140375 immune receptor activity 35/2150 156/18639 0.224358974358974 1.94503577817531 7.7665749018163e-05 0.00466282142049042 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 31/2150 132/18639 0.234848484848485 2.03597251585624 7.94799105765413e-05 0.00466282142049042 GO:0032813 tumor necrosis factor receptor superfamily binding 16/2150 50/18639 0.32 2.77417674418605 9.78667605594193e-05 0.00548053859132748 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 29/2150 122/18639 0.237704918032787 2.06073579870377 0.000105980550762958 0.00567687124086804 GO:0051020 GTPase binding 59/2150 315/18639 0.187301587301587 1.62377408637874 0.000112481941033708 0.00577407297306367 GO:0070008 serine-type exopeptidase activity 7/2150 12/18639 0.583333333333333 5.05709302325581 0.00012577774388644 0.00619832721872378 GO:0031267 small GTPase binding 54/2150 283/18639 0.190812720848057 1.65421316459857 0.000131338669896714 0.00622343235818275 GO:0019787 ubiquitin-like protein transferase activity 82/2150 479/18639 0.171189979123173 1.48409768412876 0.000154877873626159 0.0070670200113862 GO:0030695 GTPase regulator activity 83/2150 489/18639 0.169734151329243 1.47147667284919 0.00018907653009623 0.00831936732423412 GO:0060589 nucleoside-triphosphatase regulator activity 83/2150 490/18639 0.169387755102041 1.46847365923113 0.000202468902343193 0.00860143750644186 GO:0015485 cholesterol binding 16/2150 54/18639 0.296296296296296 2.56868217054264 0.000267802111695888 0.0109977400536445 GO:0016755 aminoacyltransferase activity 83/2150 496/18639 0.167338709677419 1.45070986496624 0.000302674432474929 0.0120288677680359 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 17/2150 60/18639 0.283333333333333 2.4563023255814 0.000315199584695643 0.0121351840107822 GO:0019207 kinase regulator activity 53/2150 287/18639 0.184668989547038 1.60095130054291 0.000349818631134545 0.0130598955623563 GO:0005126 cytokine receptor binding 51/2150 275/18639 0.185454545454545 1.60776152219873 0.000403606193178561 0.014624789117529 GO:0042277 peptide binding 47/2150 249/18639 0.188755020080321 1.63637433454749 0.000445567966995745 0.0156839924382502 GO:0030228 lipoprotein particle receptor activity 8/2150 18/18639 0.444444444444444 3.85302325581395 0.000464738319136931 0.0159043780326861 GO:0016877 ligase activity, forming carbon-sulfur bonds 13/2150 41/18639 0.317073170731707 2.74880317640386 0.000479723852789773 0.015973507746946 GO:0016504 peptidase activator activity 16/2150 57/18639 0.280701754385965 2.43348837209302 0.000525582350883066 0.0165660046051479 GO:0032934 sterol binding 18/2150 68/18639 0.264705882352941 2.29481532147743 0.000529676647895519 0.0165660046051479 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 22/2150 91/18639 0.241758241758242 2.09587528750319 0.000537857292374931 0.0165660046051479 GO:0043394 proteoglycan binding 12/2150 37/18639 0.324324324324324 2.81166561910748 0.000624649736416951 0.0180641686666584 GO:0061134 peptidase regulator activity 43/2150 226/18639 0.190265486725664 1.64946902654867 0.000642220190451537 0.0180641686666584 GO:0019107 myristoyltransferase activity 6/2150 11/18639 0.545454545454545 4.72871035940803 0.000645148880952085 0.0180641686666584 GO:0042608 T cell receptor binding 6/2150 11/18639 0.545454545454545 4.72871035940803 0.000645148880952085 0.0180641686666584 GO:0120227 acyl-CoA binding 8/2150 19/18639 0.421052631578947 3.65023255813953 0.000721922717252004 0.0197646397256549 GO:0016798 hydrolase activity, acting on glycosyl bonds 28/2150 130/18639 0.215384615384615 1.8672343470483 0.000770457946355688 0.0206348736937002 GO:0003925 G protein activity 15/2150 54/18639 0.277777777777778 2.40813953488372 0.00087615127385733 0.0229344050321691 GO:0004622 lysophospholipase activity 9/2150 24/18639 0.375 3.25098837209302 0.000918883128582207 0.0229344050321691 GO:0060229 lipase activator activity 9/2150 24/18639 0.375 3.25098837209302 0.000918883128582207 0.0229344050321691 GO:0005085 guanyl-nucleotide exchange factor activity 43/2150 230/18639 0.18695652173913 1.62078260869565 0.000930779425006861 0.0229344050321691 GO:0016790 thiolester hydrolase activity 13/2150 44/18639 0.295454545454545 2.56138477801269 0.00101547415362408 0.0233678124199722 GO:0005525 GTP binding 64/2150 378/18639 0.169312169312169 1.46781838316722 0.00103780794309264 0.0233678124199722 GO:0019001 guanyl nucleotide binding 67/2150 400/18639 0.1675 1.45210813953488 0.00107232834299296 0.0233678124199722 GO:0032561 guanyl ribonucleotide binding 67/2150 400/18639 0.1675 1.45210813953488 0.00107232834299296 0.0233678124199722 GO:0008374 O-acyltransferase activity 15/2150 55/18639 0.272727272727273 2.36435517970402 0.0010780750776821 0.0233678124199722 GO:0016004 phospholipase activator activity 8/2150 20/18639 0.4 3.46772093023256 0.00108228704651562 0.0233678124199722 GO:1901981 phosphatidylinositol phosphate binding 36/2150 185/18639 0.194594594594595 1.68699937146449 0.00112030191639685 0.0233678124199722 GO:0061659 ubiquitin-like protein ligase activity 63/2150 372/18639 0.169354838709677 1.46818829707427 0.00112316312633854 0.0233678124199722 GO:0004860 protein kinase inhibitor activity 20/2150 84/18639 0.238095238095238 2.0641196013289 0.00115615654814384 0.0233678124199722 GO:0019210 kinase inhibitor activity 21/2150 90/18639 0.233333333333333 2.02283720930233 0.00116296550777268 0.0233678124199722 GO:0000062 fatty-acyl-CoA binding 7/2150 16/18639 0.4375 3.79281976744186 0.00119494495329403 0.0233678124199722 GO:0015923 mannosidase activity 7/2150 16/18639 0.4375 3.79281976744186 0.00119494495329403 0.0233678124199722 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 7/2150 16/18639 0.4375 3.79281976744186 0.00119494495329403 0.0233678124199722 GO:0003924 GTPase activity 57/2150 331/18639 0.172205438066465 1.49290100470737 0.00126703921954383 0.0243905049762188 GO:0120020 cholesterol transfer activity 9/2150 25/18639 0.36 3.1209488372093 0.00129008111942735 0.0244519990636076 GO:0009055 electron transfer activity 25/2150 116/18639 0.21551724137931 1.86838412189254 0.00142171572352153 0.0265386935057352 GO:0004842 ubiquitin-protein transferase activity 73/2150 449/18639 0.162583518930958 1.40948567876936 0.00151855997325609 0.0279233714485299 GO:0043178 alcohol binding 21/2150 92/18639 0.228260869565217 1.97886248736097 0.00156326734871079 0.0280844697594204 GO:0005123 death receptor binding 8/2150 21/18639 0.380952380952381 3.30259136212625 0.00157291267321429 0.0280844697594204 GO:0008484 sulfuric ester hydrolase activity 7/2150 17/18639 0.411764705882353 3.56971272229822 0.00183040787506342 0.0305799462733044 GO:0036041 long-chain fatty acid binding 7/2150 17/18639 0.411764705882353 3.56971272229822 0.00183040787506342 0.0305799462733044 GO:1901567 fatty acid derivative binding 7/2150 17/18639 0.411764705882353 3.56971272229822 0.00183040787506342 0.0305799462733044 GO:0016411 acylglycerol O-acyltransferase activity 10/2150 31/18639 0.32258064516129 2.79654913728432 0.00183678248719523 0.0305799462733044 GO:0016878 acid-thiol ligase activity 10/2150 31/18639 0.32258064516129 2.79654913728432 0.00183678248719523 0.0305799462733044 GO:0061135 endopeptidase regulator activity 35/2150 184/18639 0.190217391304348 1.64905207280081 0.00195415758113079 0.0316604627316305 GO:0000149 SNARE binding 23/2150 106/18639 0.216981132075472 1.88107503290917 0.00196719358601335 0.0316604627316305 GO:0005504 fatty acid binding 13/2150 47/18639 0.276595744680851 2.39789213260762 0.00197877892072691 0.0316604627316305 GO:0061133 endopeptidase activator activity 8/2150 22/18639 0.363636363636364 3.15247357293869 0.00222418143131027 0.0351306605560801 GO:0120015 sterol transfer activity 10/2150 32/18639 0.3125 2.70915697674419 0.00239912590309372 0.0371622272453224 GO:0038024 cargo receptor activity 16/2150 65/18639 0.246153846153846 2.13398211091234 0.00241313163930665 0.0371622272453224 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 14/2150 54/18639 0.259259259259259 2.24759689922481 0.00263305852764169 0.0395600988543239 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 14/2150 54/18639 0.259259259259259 2.24759689922481 0.00263305852764169 0.0395600988543239 GO:0000287 magnesium ion binding 41/2150 230/18639 0.178260869565217 1.5453973710819 0.00301873258670825 0.0425091553612284 GO:0004602 glutathione peroxidase activity 8/2150 23/18639 0.347826086956522 3.01540950455005 0.00306947466284377 0.0425091553612284 GO:0005545 1-phosphatidylinositol binding 6/2150 14/18639 0.428571428571429 3.71541528239203 0.00308530650357536 0.0425091553612284 GO:0008474 palmitoyl-(protein) hydrolase activity 6/2150 14/18639 0.428571428571429 3.71541528239203 0.00308530650357536 0.0425091553612284 GO:0098599 palmitoyl hydrolase activity 6/2150 14/18639 0.428571428571429 3.71541528239203 0.00308530650357536 0.0425091553612284 GO:0004090 carbonyl reductase (NADPH) activity 5/2150 10/18639 0.5 4.3346511627907 0.00310537660918065 0.0425091553612284 GO:0015924 mannosyl-oligosaccharide mannosidase activity 5/2150 10/18639 0.5 4.3346511627907 0.00310537660918065 0.0425091553612284 GO:0043422 protein kinase B binding 5/2150 10/18639 0.5 4.3346511627907 0.00310537660918065 0.0425091553612284 GO:0051019 mitogen-activated protein kinase binding 9/2150 28/18639 0.321428571428571 2.78656146179402 0.00316730675114358 0.0428804606308669 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 26/2150 130/18639 0.2 1.73386046511628 0.00348305644402187 0.0466426689025537 GO:0003712 transcription coregulator activity 77/2150 495/18639 0.155555555555556 1.34855813953488 0.00382377448865636 0.0506547330110176 GO:0019887 protein kinase regulator activity 44/2150 255/18639 0.172549019607843 1.49587961696306 0.00409202912008831 0.0536317008079659 GO:0005507 copper ion binding 15/2150 63/18639 0.238095238095238 2.0641196013289 0.00456591342876011 0.0583911969478952 GO:0004559 alpha-mannosidase activity 6/2150 15/18639 0.4 3.46772093023256 0.00464475430267349 0.0583911969478952 GO:0005041 low-density lipoprotein particle receptor activity 6/2150 15/18639 0.4 3.46772093023256 0.00464475430267349 0.0583911969478952 GO:0050700 CARD domain binding 6/2150 15/18639 0.4 3.46772093023256 0.00464475430267349 0.0583911969478952 GO:0004674 protein serine/threonine kinase activity 68/2150 433/18639 0.157043879907621 1.36146087330147 0.0050308696803039 0.0626063782437819 GO:0008526 phosphatidylinositol transfer activity 5/2150 11/18639 0.454545454545455 3.94059196617336 0.00515556638270444 0.0635165778349187 GO:0008106 alcohol dehydrogenase (NADP+) activity 9/2150 30/18639 0.3 2.60079069767442 0.00530531389740229 0.0645590166383783 GO:0016408 C-acyltransferase activity 7/2150 20/18639 0.35 3.03425581395349 0.00534498352038522 0.0645590166383783 GO:0005496 steroid binding 22/2150 108/18639 0.203703703703704 1.76596899224806 0.0054595150866732 0.0653021610367124 GO:0008238 exopeptidase activity 21/2150 102/18639 0.205882352941176 1.78485636114911 0.00575780483053689 0.0682078418386677 GO:0004620 phospholipase activity 22/2150 109/18639 0.201834862385321 1.74976744186047 0.00611311407730374 0.0715518169621219 GO:0004033 aldo-keto reductase (NADPH) activity 10/2150 36/18639 0.277777777777778 2.40813953488372 0.00615624399187088 0.0715518169621219 GO:0035402 histone H3T11 kinase activity 42/2150 247/18639 0.17004048582996 1.47413237924866 0.00641428938588381 0.0738542478823257 GO:0002020 protease binding 26/2150 136/18639 0.191176470588235 1.65736662106703 0.00647672291306854 0.0738826169342633 GO:0016722 oxidoreductase activity, acting on metal ions 6/2150 16/18639 0.375 3.25098837209302 0.00671463991230117 0.0758939116693123 GO:0004679 AMP-activated protein kinase activity 42/2150 248/18639 0.169354838709677 1.46818829707427 0.00688346143172413 0.0769994622041998 GO:0016298 lipase activity 25/2150 130/18639 0.192307692307692 1.66717352415027 0.00693745154599527 0.0769994622041998 GO:0005096 GTPase activator activity 45/2150 271/18639 0.166051660516605 1.43955204668326 0.00758978085246917 0.0825913413908403 GO:0033293 monocarboxylic acid binding 17/2150 79/18639 0.215189873417722 1.86554607006182 0.00782002711500921 0.0825913413908403 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 41/2150 243/18639 0.168724279835391 1.462721791559 0.00800382935268468 0.0825913413908403 GO:0052689 carboxylic ester hydrolase activity 19/2150 92/18639 0.206521739130435 1.79039939332659 0.00808190895236339 0.0825913413908403 GO:0061630 ubiquitin protein ligase activity 56/2150 353/18639 0.158640226628895 1.37530008564464 0.00831863037263276 0.0825913413908403 GO:0008234 cysteine-type peptidase activity 33/2150 187/18639 0.176470588235294 1.52987688098495 0.00842232642240315 0.0825913413908403 GO:0030246 carbohydrate binding 46/2150 280/18639 0.164285714285714 1.42424252491694 0.00850672463999464 0.0825913413908403 GO:0140313 molecular sequestering activity 13/2150 55/18639 0.236363636363636 2.04910782241015 0.00851573050811396 0.0825913413908403 GO:0004364 glutathione transferase activity 8/2150 27/18639 0.296296296296296 2.56868217054264 0.00913864553215312 0.0825913413908403 GO:0004676 3-phosphoinositide-dependent protein kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0004711 ribosomal protein S6 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0035175 histone H3S10 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0035979 histone H2AXS139 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0044022 histone H3S28 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0044023 histone H4S1 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0044024 histone H2AS1 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0044025 histone H2BS14 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0072354 histone H3T3 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0072371 histone H2AS121 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0072518 Rho-dependent protein serine/threonine kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0140823 histone H2BS36 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0140855 histone H3S57 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0140995 histone H2A kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0140997 histone H4 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0140998 histone H2B kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:1990244 histone H2AT120 kinase activity 41/2150 245/18639 0.16734693877551 1.45078120550546 0.00918426442414377 0.0825913413908403 GO:0030169 low-density lipoprotein particle binding 6/2150 17/18639 0.352941176470588 3.0597537619699 0.00937876647806723 0.0837292775433248 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 7/2150 22/18639 0.318181818181818 2.75841437632135 0.00956754311654552 0.0842092557897552 GO:0030145 manganese ion binding 15/2150 68/18639 0.220588235294118 1.91234610123119 0.00956923361247218 0.0842092557897552 GO:0004677 DNA-dependent protein kinase activity 41/2150 246/18639 0.166666666666667 1.44488372093023 0.00982664884596067 0.0852565590015743 GO:0140857 histone H3T45 kinase activity 41/2150 246/18639 0.166666666666667 1.44488372093023 0.00982664884596067 0.0852565590015743 GO:0004857 enzyme inhibitor activity 64/2150 416/18639 0.153846153846154 1.33373881932021 0.00992640010660433 0.0855197547645912 GO:0015101 organic cation transmembrane transporter activity 17/2150 81/18639 0.209876543209877 1.81948320413437 0.010073663131197 0.0861857845669077 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 9/2150 33/18639 0.272727272727273 2.36435517970402 0.0104136398498884 0.0877131653541893 GO:0140311 protein sequestering activity 9/2150 33/18639 0.272727272727273 2.36435517970402 0.0104136398498884 0.0877131653541893 GO:0035403 histone H3T6 kinase activity 41/2150 247/18639 0.165991902834008 1.43903398926655 0.0105058077676264 0.0877131653541893 GO:0003725 double-stranded RNA binding 16/2150 75/18639 0.213333333333333 1.8494511627907 0.0105369711626786 0.0877131653541893 GO:0019789 SUMO transferase activity 8/2150 28/18639 0.285714285714286 2.47694352159468 0.0115271810445569 0.0949366024135926 GO:0030544 Hsp70 protein binding 12/2150 51/18639 0.235294117647059 2.03983584131327 0.0116655666095369 0.0949366024135926 GO:0003713 transcription coactivator activity 42/2150 256/18639 0.1640625 1.4223074127907 0.0117767253242101 0.0949366024135926 GO:0035325 Toll-like receptor binding 5/2150 13/18639 0.384615384615385 3.33434704830054 0.0117900163711686 0.0949366024135926 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 5/2150 13/18639 0.384615384615385 3.33434704830054 0.0117900163711686 0.0949366024135926 GO:0005158 insulin receptor binding 7/2150 23/18639 0.304347826086957 2.63848331648129 0.0124104480650401 0.0980107180521113 GO:0042171 lysophosphatidic acid acyltransferase activity 7/2150 23/18639 0.304347826086957 2.63848331648129 0.0124104480650401 0.0980107180521113 GO:0071617 lysophospholipid acyltransferase activity 7/2150 23/18639 0.304347826086957 2.63848331648129 0.0124104480650401 0.0980107180521113 GO:0016407 acetyltransferase activity 19/2150 96/18639 0.197916666666667 1.71579941860465 0.0127167193567431 0.098547715311358 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 6/2150 18/18639 0.333333333333333 2.88976744186047 0.0127184145572288 0.098547715311358 GO:0004706 JUN kinase kinase kinase activity 6/2150 18/18639 0.333333333333333 2.88976744186047 0.0127184145572288 0.098547715311358 GO:0016829 lyase activity 34/2150 200/18639 0.17 1.47378139534884 0.0131954464838253 0.101604937925455 GO:0004177 aminopeptidase activity 10/2150 40/18639 0.25 2.16732558139535 0.0134054553134709 0.102580875442212 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 12/2150 52/18639 0.230769230769231 2.00060822898032 0.013615013938012 0.103541340565622 GO:0120013 lipid transfer activity 14/2150 65/18639 0.215384615384615 1.8672343470483 0.0148364900873006 0.11213837906475 GO:0005154 epidermal growth factor receptor binding 9/2150 35/18639 0.257142857142857 2.22924916943522 0.0154456229535106 0.115327318052879 GO:0016229 steroid dehydrogenase activity 9/2150 35/18639 0.257142857142857 2.22924916943522 0.0154456229535106 0.115327318052879 GO:0070851 growth factor receptor binding 25/2150 139/18639 0.179856115107914 1.55922703697507 0.0159165056175985 0.116927761583515 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 10/2150 41/18639 0.24390243902439 2.11446398184912 0.0159446947613885 0.116927761583515 GO:0042287 MHC protein binding 10/2150 41/18639 0.24390243902439 2.11446398184912 0.0159446947613885 0.116927761583515 GO:0008191 metalloendopeptidase inhibitor activity 5/2150 14/18639 0.357142857142857 3.09617940199336 0.0166259662976093 0.119784739641255 GO:0044548 S100 protein binding 5/2150 14/18639 0.357142857142857 3.09617940199336 0.0166259662976093 0.119784739641255 GO:0061665 SUMO ligase activity 5/2150 14/18639 0.357142857142857 3.09617940199336 0.0166259662976093 0.119784739641255 GO:0004175 endopeptidase activity 61/2150 405/18639 0.150617283950617 1.30574677002584 0.0176283503618821 0.125568887561158 GO:0001968 fibronectin binding 8/2150 30/18639 0.266666666666667 2.31181395348837 0.0176326441137016 0.125568887561158 GO:0016209 antioxidant activity 17/2150 86/18639 0.197674418604651 1.71369929691725 0.017985760953495 0.127347456866125 GO:0051287 NAD binding 12/2150 54/18639 0.222222222222222 1.92651162790698 0.0182465984476925 0.128456053071755 GO:0004190 aspartic-type endopeptidase activity 9/2150 36/18639 0.25 2.16732558139535 0.0185420826073906 0.129794578251734 GO:0106310 protein serine kinase activity 55/2150 361/18639 0.152354570637119 1.32080783353733 0.0189581132985152 0.131957037196445 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 14/2150 67/18639 0.208955223880597 1.81149600833044 0.0191522322322444 0.132559270281601 GO:0015645 fatty acid ligase activity 7/2150 25/18639 0.28 2.42740465116279 0.0198295546771924 0.134230831660995 GO:0047617 fatty acyl-CoA hydrolase activity 7/2150 25/18639 0.28 2.42740465116279 0.0198295546771924 0.134230831660995 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 7/2150 25/18639 0.28 2.42740465116279 0.0198295546771924 0.134230831660995 GO:0120515 fatty acid-CoA ligase activity 7/2150 25/18639 0.28 2.42740465116279 0.0198295546771924 0.134230831660995 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 13/2150 61/18639 0.213114754098361 1.84755623332063 0.0201065826636722 0.134626683921979 GO:0019905 syntaxin binding 13/2150 61/18639 0.213114754098361 1.84755623332063 0.0201065826636722 0.134626683921979 GO:0005345 purine nucleobase transmembrane transporter activity 4/2150 10/18639 0.4 3.46772093023256 0.020902667052319 0.136979179832218 GO:0008239 dipeptidyl-peptidase activity 4/2150 10/18639 0.4 3.46772093023256 0.020902667052319 0.136979179832218 GO:0070513 death domain binding 4/2150 10/18639 0.4 3.46772093023256 0.020902667052319 0.136979179832218 GO:1905394 retromer complex binding 4/2150 10/18639 0.4 3.46772093023256 0.020902667052319 0.136979179832218 GO:0005164 tumor necrosis factor receptor binding 8/2150 31/18639 0.258064516129032 2.23723930982746 0.0214268651740449 0.139671417430811 GO:0016505 peptidase activator activity involved in apoptotic process 6/2150 20/18639 0.3 2.60079069767442 0.0217237584978748 0.140123929159067 GO:0042288 MHC class I protein binding 6/2150 20/18639 0.3 2.60079069767442 0.0217237584978748 0.140123929159067 GO:0070001 aspartic-type peptidase activity 9/2150 37/18639 0.243243243243243 2.10874921433061 0.0220650571614144 0.140858612739053 GO:0008375 acetylglucosaminyltransferase activity 10/2150 43/18639 0.232558139534884 2.01611681990265 0.0220663248852574 0.140858612739053 GO:0004467 long-chain fatty acid-CoA ligase activity 5/2150 15/18639 0.333333333333333 2.88976744186047 0.0226165722950771 0.142161311569056 GO:0015929 hexosaminidase activity 5/2150 15/18639 0.333333333333333 2.88976744186047 0.0226165722950771 0.142161311569056 GO:0017081 chloride channel regulator activity 5/2150 15/18639 0.333333333333333 2.88976744186047 0.0226165722950771 0.142161311569056 GO:0015179 L-amino acid transmembrane transporter activity 13/2150 62/18639 0.209677419354839 1.81775693923481 0.0228380831716049 0.142824966839681 GO:0008198 ferrous iron binding 7/2150 26/18639 0.269230769230769 2.33404293381038 0.0245049278144711 0.150950355337142 GO:0016289 acyl-CoA hydrolase activity 7/2150 26/18639 0.269230769230769 2.33404293381038 0.0245049278144711 0.150950355337142 GO:0070006 metalloaminopeptidase activity 7/2150 26/18639 0.269230769230769 2.33404293381038 0.0245049278144711 0.150950355337142 GO:0015399 primary active transmembrane transporter activity 28/2150 166/18639 0.168674698795181 1.4622919585318 0.0250707870255052 0.153667709529465 GO:0051059 NF-kappaB binding 8/2150 32/18639 0.25 2.16732558139535 0.0257635863051177 0.155591854548554 GO:0071813 lipoprotein particle binding 8/2150 32/18639 0.25 2.16732558139535 0.0257635863051177 0.155591854548554 GO:0071814 protein-lipid complex binding 8/2150 32/18639 0.25 2.16732558139535 0.0257635863051177 0.155591854548554 GO:0031072 heat shock protein binding 23/2150 131/18639 0.175572519083969 1.52209124800284 0.0261077973713186 0.156901494446168 GO:0004601 peroxidase activity 12/2150 57/18639 0.210526315789474 1.82511627906977 0.0272743379377161 0.163116428831389 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 6/2150 21/18639 0.285714285714286 2.47694352159468 0.0275208543194364 0.163795616046114 GO:0022853 active monoatomic ion transmembrane transporter activity 21/2150 118/18639 0.177966101694915 1.54284193929838 0.0283871571161029 0.168139315226148 GO:0004866 endopeptidase inhibitor activity 27/2150 161/18639 0.167701863354037 1.45385815397949 0.0292944010899389 0.168790331673118 GO:0005149 interleukin-1 receptor binding 5/2150 16/18639 0.3125 2.70915697674419 0.0298447233781571 0.168790331673118 GO:0022858 alanine transmembrane transporter activity 5/2150 16/18639 0.3125 2.70915697674419 0.0298447233781571 0.168790331673118 GO:0005044 scavenger receptor activity 7/2150 27/18639 0.259259259259259 2.24759689922481 0.0298831266132824 0.168790331673118 GO:0016405 CoA-ligase activity 7/2150 27/18639 0.259259259259259 2.24759689922481 0.0298831266132824 0.168790331673118 GO:0015173 aromatic amino acid transmembrane transporter activity 4/2150 11/18639 0.363636363636364 3.15247357293869 0.0299010102920987 0.168790331673118 GO:0015205 nucleobase transmembrane transporter activity 4/2150 11/18639 0.363636363636364 3.15247357293869 0.0299010102920987 0.168790331673118 GO:0032050 clathrin heavy chain binding 4/2150 11/18639 0.363636363636364 3.15247357293869 0.0299010102920987 0.168790331673118 GO:0047676 arachidonate-CoA ligase activity 4/2150 11/18639 0.363636363636364 3.15247357293869 0.0299010102920987 0.168790331673118 GO:0050786 RAGE receptor binding 4/2150 11/18639 0.363636363636364 3.15247357293869 0.0299010102920987 0.168790331673118 GO:0042578 phosphoric ester hydrolase activity 54/2150 363/18639 0.148760330578512 1.28964827983855 0.0300041255165689 0.168790331673118 GO:0042626 ATPase-coupled transmembrane transporter activity 18/2150 98/18639 0.183673469387755 1.59232083531087 0.0304344877522793 0.17023559107394 GO:0019239 deaminase activity 8/2150 33/18639 0.242424242424242 2.10164904862579 0.0306755691707911 0.17023559107394 GO:0071889 14-3-3 protein binding 8/2150 33/18639 0.242424242424242 2.10164904862579 0.0306755691707911 0.17023559107394 GO:0051087 protein-folding chaperone binding 23/2150 134/18639 0.171641791044776 1.48801457827143 0.0330421147701036 0.182546571285954 GO:0003779 actin binding 64/2150 443/18639 0.144469525959368 1.25244999737519 0.0339182506773479 0.186013350064161 GO:0015078 proton transmembrane transporter activity 30/2150 185/18639 0.162162162162162 1.40583280955374 0.0339715939646398 0.186013350064161 GO:0001786 phosphatidylserine binding 12/2150 59/18639 0.203389830508475 1.76324793062672 0.0348634840725217 0.188385142005907 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 12/2150 59/18639 0.203389830508475 1.76324793062672 0.0348634840725217 0.188385142005907 GO:0031593 polyubiquitin modification-dependent protein binding 12/2150 59/18639 0.203389830508475 1.76324793062672 0.0348634840725217 0.188385142005907 GO:0015036 disulfide oxidoreductase activity 9/2150 40/18639 0.225 1.95059302325581 0.0354639861363664 0.189141259393954 GO:0061791 GTPase motor activity 9/2150 40/18639 0.225 1.95059302325581 0.0354639861363664 0.189141259393954 GO:1990606 membrane scission GTPase motor activity 9/2150 40/18639 0.225 1.95059302325581 0.0354639861363664 0.189141259393954 GO:0050660 flavin adenine dinucleotide binding 16/2150 86/18639 0.186046511627907 1.61289345592212 0.0357214530411622 0.189693233390999 GO:0051537 2 iron, 2 sulfur cluster binding 7/2150 28/18639 0.25 2.16732558139535 0.0360017751361908 0.190361317458314 GO:1901505 carbohydrate derivative transmembrane transporter activity 11/2150 53/18639 0.207547169811321 1.79928916191312 0.0370350437915257 0.194987922868204 GO:0004029 aldehyde dehydrogenase (NAD+) activity 5/2150 17/18639 0.294117647058824 2.54979480164159 0.0383722054198612 0.198632592761635 GO:0048038 quinone binding 5/2150 17/18639 0.294117647058824 2.54979480164159 0.0383722054198612 0.198632592761635 GO:0070402 NADPH binding 5/2150 17/18639 0.294117647058824 2.54979480164159 0.0383722054198612 0.198632592761635 GO:0070403 NAD+ binding 5/2150 17/18639 0.294117647058824 2.54979480164159 0.0383722054198612 0.198632592761635 GO:0035591 signaling adaptor activity 22/2150 129/18639 0.170542635658915 1.47848566792861 0.0388371459259358 0.200198174814866 GO:0019903 protein phosphatase binding 24/2150 144/18639 0.166666666666667 1.44488372093023 0.0406446598607124 0.201820261525733 GO:0016208 AMP binding 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:0016840 carbon-nitrogen lyase activity 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:0035014 phosphatidylinositol 3-kinase regulator activity 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:0035197 siRNA binding 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:1990459 transferrin receptor binding 4/2150 12/18639 0.333333333333333 2.88976744186047 0.040848358545122 0.201820261525733 GO:0001530 lipopolysaccharide binding 9/2150 41/18639 0.219512195121951 1.90301758366421 0.0409537868355789 0.201820261525733 GO:0050661 NADP binding 11/2150 54/18639 0.203703703703704 1.76596899224806 0.0418413902748319 0.205150509043113 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 6/2150 23/18639 0.260869565217391 2.26155712841254 0.0419626041224548 0.205150509043113 GO:0140297 DNA-binding transcription factor binding 69/2150 488/18639 0.141393442622951 1.22578250095311 0.0426336178708049 0.207607182675224 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 7/2150 29/18639 0.241379310344828 2.09259021651965 0.0428924539344264 0.207946309634002 GO:0016651 oxidoreductase activity, acting on NAD(P)H 16/2150 88/18639 0.181818181818182 1.57623678646934 0.0430408351921026 0.207946309634002 GO:0048487 beta-tubulin binding 9/2150 42/18639 0.214285714285714 1.85770764119601 0.0469892544068469 0.225856796104689 GO:0004896 cytokine receptor activity 17/2150 96/18639 0.177083333333333 1.53518895348837 0.0471146076289814 0.225856796104689 GO:0017075 syntaxin-1 binding 5/2150 18/18639 0.277777777777778 2.40813953488372 0.0482390480593352 0.228578873881157 GO:0032393 MHC class I receptor activity 5/2150 18/18639 0.277777777777778 2.40813953488372 0.0482390480593352 0.228578873881157 GO:0034185 apolipoprotein binding 5/2150 18/18639 0.277777777777778 2.40813953488372 0.0482390480593352 0.228578873881157 GO:0044390 ubiquitin-like protein conjugating enzyme binding 8/2150 36/18639 0.222222222222222 1.92651162790698 0.0491386725366651 0.231949596035139 GO:0030414 peptidase inhibitor activity 27/2150 169/18639 0.159763313609467 1.38503646621715 0.0497512089557621 0.233843834527706 GO:0016763 pentosyltransferase activity 10/2150 49/18639 0.204081632653061 1.76924537256763 0.0503439393297181 0.233843834527706 GO:0001965 G-protein alpha-subunit binding 7/2150 30/18639 0.233333333333333 2.02283720930233 0.050580222140734 0.233843834527706 GO:0031624 ubiquitin conjugating enzyme binding 7/2150 30/18639 0.233333333333333 2.02283720930233 0.050580222140734 0.233843834527706 GO:0015295 solute:proton symporter activity 6/2150 24/18639 0.25 2.16732558139535 0.0506788180348194 0.233843834527706 GO:0070300 phosphatidic acid binding 6/2150 24/18639 0.25 2.16732558139535 0.0506788180348194 0.233843834527706 GO:0001540 amyloid-beta binding 15/2150 83/18639 0.180722891566265 1.56674138414122 0.0512715391193064 0.235696030578304 GO:0035173 histone kinase activity 52/2150 360/18639 0.144444444444444 1.25223255813953 0.0515612292614217 0.236146596468667 GO:0004712 protein serine/threonine/tyrosine kinase activity 9/2150 43/18639 0.209302325581395 1.81450513791239 0.0535865004566795 0.240859034255174 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/2150 13/18639 0.307692307692308 2.66747763864043 0.0537631772891014 0.240859034255174 GO:0008035 high-density lipoprotein particle binding 4/2150 13/18639 0.307692307692308 2.66747763864043 0.0537631772891014 0.240859034255174 GO:0043560 insulin receptor substrate binding 4/2150 13/18639 0.307692307692308 2.66747763864043 0.0537631772891014 0.240859034255174 GO:0089720 caspase binding 4/2150 13/18639 0.307692307692308 2.66747763864043 0.0537631772891014 0.240859034255174 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 4/2150 13/18639 0.307692307692308 2.66747763864043 0.0537631772891014 0.240859034255174 GO:0070003 threonine-type peptidase activity 5/2150 19/18639 0.263157894736842 2.28139534883721 0.0594636630788735 0.265432003308595 GO:0004709 MAP kinase kinase kinase activity 6/2150 25/18639 0.24 2.08063255813953 0.0604206906740701 0.266803910073313 GO:0019706 protein-cysteine S-palmitoyltransferase activity 6/2150 25/18639 0.24 2.08063255813953 0.0604206906740701 0.266803910073313 GO:0019707 protein-cysteine S-acyltransferase activity 6/2150 25/18639 0.24 2.08063255813953 0.0604206906740701 0.266803910073313 GO:0140996 histone H3 kinase activity 51/2150 357/18639 0.142857142857143 1.23847176079734 0.0626152887906575 0.275507270678893 GO:0003743 translation initiation factor activity 10/2150 51/18639 0.196078431372549 1.69986320109439 0.0635419245298769 0.277601599364569 GO:0016830 carbon-carbon lyase activity 10/2150 51/18639 0.196078431372549 1.69986320109439 0.0635419245298769 0.277601599364569 GO:0046332 SMAD binding 14/2150 79/18639 0.177215189873418 1.53633205769797 0.0667849963379877 0.290738923987282 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/2150 32/18639 0.21875 1.89640988372093 0.068412800108937 0.292517134936956 GO:0141110 transporter inhibitor activity 9/2150 45/18639 0.2 1.73386046511628 0.0685150398378288 0.292517134936956 GO:0004065 arylsulfatase activity 4/2150 14/18639 0.285714285714286 2.47694352159468 0.0686180616856983 0.292517134936956 GO:0019992 diacylglycerol binding 4/2150 14/18639 0.285714285714286 2.47694352159468 0.0686180616856983 0.292517134936956 GO:0071933 Arp2/3 complex binding 4/2150 14/18639 0.285714285714286 2.47694352159468 0.0686180616856983 0.292517134936956 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 4/2150 14/18639 0.285714285714286 2.47694352159468 0.0686180616856983 0.292517134936956 GO:0019902 phosphatase binding 29/2150 190/18639 0.152631578947368 1.32320930232558 0.0704426411345268 0.298342710419599 GO:0004721 phosphoprotein phosphatase activity 27/2150 175/18639 0.154285714285714 1.33754950166113 0.0708014487223596 0.298342710419599 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 6/2150 26/18639 0.230769230769231 2.00060822898032 0.0711954195319498 0.298342710419599 GO:0019865 immunoglobulin binding 6/2150 26/18639 0.230769230769231 2.00060822898032 0.0711954195319498 0.298342710419599 GO:0120014 phospholipid transfer activity 6/2150 26/18639 0.230769230769231 2.00060822898032 0.0711954195319498 0.298342710419599 GO:0001614 purinergic nucleotide receptor activity 5/2150 20/18639 0.25 2.16732558139535 0.0720436312725397 0.298847655649053 GO:0016502 nucleotide receptor activity 5/2150 20/18639 0.25 2.16732558139535 0.0720436312725397 0.298847655649053 GO:0030742 GTP-dependent protein binding 5/2150 20/18639 0.25 2.16732558139535 0.0720436312725397 0.298847655649053 GO:0008235 metalloexopeptidase activity 12/2150 66/18639 0.181818181818182 1.57623678646934 0.0729488677629438 0.301587265382372 GO:0141003 histone H2AX kinase activity 50/2150 354/18639 0.141242937853107 1.22447772960189 0.0755857800931058 0.311443749413734 GO:0004180 carboxypeptidase activity 9/2150 46/18639 0.195652173913043 1.6961678463094 0.0768624160790483 0.313134631711001 GO:1990782 protein tyrosine kinase binding 19/2150 117/18639 0.162393162393162 1.40783542039356 0.0777942926248294 0.313134631711001 GO:0005544 calcium-dependent phospholipid binding 10/2150 53/18639 0.188679245283019 1.63571741992102 0.07877838759467 0.313134631711001 GO:0001618 virus receptor activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:0033192 calmodulin-dependent protein phosphatase activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:0140791 histone H2AXS140 phosphatase activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:1990439 MAP kinase serine/threonine phosphatase activity 14/2150 81/18639 0.172839506172839 1.49839793281654 0.0790461610893843 0.313134631711001 GO:0048029 monosaccharide binding 13/2150 74/18639 0.175675675675676 1.52298554368322 0.079703522124529 0.314726728389166 GO:0004722 protein serine/threonine phosphatase activity 17/2150 103/18639 0.16504854368932 1.43085572363965 0.0812877137463602 0.319956751870657 GO:0001671 ATPase activator activity 6/2150 27/18639 0.222222222222222 1.92651162790698 0.0829989317944262 0.324109419474851 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/2150 40/18639 0.2 1.73386046511628 0.0831319614886794 0.324109419474851 GO:0071949 FAD binding 8/2150 40/18639 0.2 1.73386046511628 0.0831319614886794 0.324109419474851 GO:0019209 kinase activator activity 23/2150 148/18639 0.155405405405405 1.347256442489 0.0843157723747528 0.325818786537814 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 15/2150 89/18639 0.168539325842697 1.46111836948001 0.084389919307042 0.325818786537814 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 15/2150 89/18639 0.168539325842697 1.46111836948001 0.084389919307042 0.325818786537814 GO:0016846 carbon-sulfur lyase activity 4/2150 15/18639 0.266666666666667 2.31181395348837 0.0853458760095606 0.325818786537814 GO:0047372 monoacylglycerol lipase activity 4/2150 15/18639 0.266666666666667 2.31181395348837 0.0853458760095606 0.325818786537814 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 14/2150 82/18639 0.170731707317073 1.48012478729438 0.0856861094466328 0.325818786537814 GO:0033549 MAP kinase phosphatase activity 14/2150 82/18639 0.170731707317073 1.48012478729438 0.0856861094466328 0.325818786537814 GO:0140272 exogenous protein binding 14/2150 82/18639 0.170731707317073 1.48012478729438 0.0856861094466328 0.325818786537814 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 7/2150 34/18639 0.205882352941176 1.78485636114911 0.0895603736842717 0.338461289506205 GO:0016831 carboxy-lyase activity 7/2150 34/18639 0.205882352941176 1.78485636114911 0.0895603736842717 0.338461289506205 GO:0140793 histone H2AXY142 phosphatase activity 15/2150 90/18639 0.166666666666667 1.44488372093023 0.0909938059359677 0.34282681624805 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 14/2150 83/18639 0.168674698795181 1.4622919585318 0.0926687758898584 0.348072963098492 GO:0016791 phosphatase activity 39/2150 273/18639 0.142857142857143 1.23847176079734 0.0931152077420588 0.348532701162967 GO:0061650 ubiquitin-like protein conjugating enzyme activity 8/2150 41/18639 0.195121951219512 1.6915711854793 0.0933569735257946 0.348532701162967 GO:0051536 iron-sulfur cluster binding 13/2150 76/18639 0.171052631578947 1.48290697674419 0.0941226906733809 0.350329773140801 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/2150 48/18639 0.1875 1.62549418604651 0.0953379572978452 0.352375309277314 GO:0032266 phosphatidylinositol-3-phosphate binding 9/2150 48/18639 0.1875 1.62549418604651 0.0953379572978452 0.352375309277314 GO:0004725 protein tyrosine phosphatase activity 16/2150 98/18639 0.163265306122449 1.41539629805411 0.0957117725726222 0.352375309277314 GO:0050698 proteoglycan sulfotransferase activity 6/2150 28/18639 0.214285714285714 1.85770764119601 0.095816338155763 0.352375309277314 GO:0003714 transcription corepressor activity 30/2150 204/18639 0.147058823529412 1.27489740082079 0.0970430295716877 0.352434309530208 GO:0072341 modified amino acid binding 15/2150 91/18639 0.164835164835165 1.42900587784309 0.0979140666121327 0.352434309530208 GO:0005131 growth hormone receptor binding 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0008641 ubiquitin-like modifier activating enzyme activity 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0031956 medium-chain fatty acid-CoA ligase activity 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0043295 glutathione binding 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0045322 unmethylated CpG binding 3/2150 10/18639 0.3 2.60079069767442 0.0989791161505291 0.352434309530208 GO:0017018 myosin phosphatase activity 14/2150 84/18639 0.166666666666667 1.44488372093023 0.0999951676528728 0.354005880886032 GO:0051117 ATPase binding 14/2150 84/18639 0.166666666666667 1.44488372093023 0.0999951676528728 0.354005880886032 GO:0140789 histone phosphatase activity 21/2150 136/18639 0.154411764705882 1.33864227086183 0.100607043856079 0.355151512981919 GO:0008970 phospholipase A1 activity 5/2150 22/18639 0.227272727272727 1.97029598308668 0.101163955849756 0.355790401515923 GO:0061631 ubiquitin conjugating enzyme activity 7/2150 35/18639 0.2 1.73386046511628 0.1013656095228 0.355790401515923 GO:0051540 metal cluster binding 13/2150 77/18639 0.168831168831169 1.46364844457868 0.101895609138849 0.356634631985973 GO:0019955 cytokine binding 22/2150 144/18639 0.152777777777778 1.32447674418605 0.103178195155094 0.360100669776418 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/2150 16/18639 0.25 2.16732558139535 0.103846260220028 0.360390401665 GO:0005521 lamin binding 4/2150 16/18639 0.25 2.16732558139535 0.103846260220028 0.360390401665 GO:0016417 S-acyltransferase activity 6/2150 29/18639 0.206896551724138 1.79364875701684 0.109622568822199 0.378305335543274 GO:0051861 glycolipid binding 6/2150 29/18639 0.206896551724138 1.79364875701684 0.109622568822199 0.378305335543274 GO:0001217 DNA-binding transcription repressor activity 39/2150 278/18639 0.140287769784173 1.21619708884056 0.113633824761997 0.391052715382067 GO:0016409 palmitoyltransferase activity 7/2150 36/18639 0.194444444444444 1.6856976744186 0.113972111553936 0.391124349399578 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 14/2150 86/18639 0.162790697674419 1.41128177393186 0.115677654711129 0.39347611647105 GO:0008200 ion channel inhibitor activity 8/2150 43/18639 0.186046511627907 1.61289345592212 0.115851144997826 0.39347611647105 GO:0048156 tau protein binding 8/2150 43/18639 0.186046511627907 1.61289345592212 0.115851144997826 0.39347611647105 GO:0033218 amide binding 35/2150 247/18639 0.1417004048583 1.22844364937388 0.115934927174506 0.39347611647105 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 5/2150 23/18639 0.217391304347826 1.88463094034378 0.117608775774007 0.398060471850484 GO:0140767 enzyme-substrate adaptor activity 21/2150 139/18639 0.151079136690647 1.30975071105906 0.119057704165172 0.401860524743814 GO:0160215 deacylase activity 11/2150 65/18639 0.169230769230769 1.46711270125224 0.123791613468247 0.40488514737907 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 4/2150 17/18639 0.235294117647059 2.03983584131327 0.123992123235465 0.40488514737907 GO:0004549 tRNA-specific ribonuclease activity 4/2150 17/18639 0.235294117647059 2.03983584131327 0.123992123235465 0.40488514737907 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4/2150 17/18639 0.235294117647059 2.03983584131327 0.123992123235465 0.40488514737907 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 4/2150 17/18639 0.235294117647059 2.03983584131327 0.123992123235465 0.40488514737907 GO:0032977 membrane insertase activity 4/2150 17/18639 0.235294117647059 2.03983584131327 0.123992123235465 0.40488514737907 GO:0046965 nuclear retinoid X receptor binding 4/2150 17/18639 0.235294117647059 2.03983584131327 0.123992123235465 0.40488514737907 GO:0031210 phosphatidylcholine binding 6/2150 30/18639 0.2 1.73386046511628 0.124383155492565 0.40488514737907 GO:0008199 ferric iron binding 3/2150 11/18639 0.272727272727273 2.36435517970402 0.12488340584744 0.40488514737907 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/2150 11/18639 0.272727272727273 2.36435517970402 0.12488340584744 0.40488514737907 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/2150 11/18639 0.272727272727273 2.36435517970402 0.12488340584744 0.40488514737907 GO:0019864 IgG binding 3/2150 11/18639 0.272727272727273 2.36435517970402 0.12488340584744 0.40488514737907 GO:0034713 type I transforming growth factor beta receptor binding 3/2150 11/18639 0.272727272727273 2.36435517970402 0.12488340584744 0.40488514737907 GO:0097493 structural molecule activity conferring elasticity 3/2150 11/18639 0.272727272727273 2.36435517970402 0.12488340584744 0.40488514737907 GO:1900750 oligopeptide binding 3/2150 11/18639 0.272727272727273 2.36435517970402 0.12488340584744 0.40488514737907 GO:0048306 calcium-dependent protein binding 13/2150 80/18639 0.1625 1.40876162790698 0.127453949726619 0.412134556596311 GO:0016248 channel inhibitor activity 8/2150 44/18639 0.181818181818182 1.57623678646934 0.128093950634403 0.413119757019853 GO:1902936 phosphatidylinositol bisphosphate binding 17/2150 111/18639 0.153153153153153 1.32773098680075 0.136411697506406 0.438796896417472 GO:0005080 protein kinase C binding 9/2150 52/18639 0.173076923076923 1.50045617173524 0.139278333148811 0.446851318852437 GO:0047499 calcium-independent phospholipase A2 activity 6/2150 31/18639 0.193548387096774 1.67792948237059 0.140055124509336 0.448176398429875 GO:0004715 non-membrane spanning protein tyrosine kinase activity 8/2150 45/18639 0.177777777777778 1.54120930232558 0.140975877293121 0.448791423320738 GO:0051539 4 iron, 4 sulfur cluster binding 8/2150 45/18639 0.177777777777778 1.54120930232558 0.140975877293121 0.448791423320738 GO:0043531 ADP binding 7/2150 38/18639 0.184210526315789 1.59697674418605 0.141492593130582 0.449275450352775 GO:0008525 phosphatidylcholine transporter activity 4/2150 18/18639 0.222222222222222 1.92651162790698 0.145635859000073 0.456548036356462 GO:0016854 racemase and epimerase activity 4/2150 18/18639 0.222222222222222 1.92651162790698 0.145635859000073 0.456548036356462 GO:0035615 clathrin adaptor activity 4/2150 18/18639 0.222222222222222 1.92651162790698 0.145635859000073 0.456548036356462 GO:0050811 GABA receptor binding 4/2150 18/18639 0.222222222222222 1.92651162790698 0.145635859000073 0.456548036356462 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/2150 18/18639 0.222222222222222 1.92651162790698 0.145635859000073 0.456548036356462 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 19/2150 128/18639 0.1484375 1.28684956395349 0.149971830018585 0.462817564527925 GO:0034212 protein N-acetyltransferase activity 9/2150 53/18639 0.169811320754717 1.47214567792892 0.151653322012159 0.462817564527925 GO:0051018 protein kinase A binding 9/2150 53/18639 0.169811320754717 1.47214567792892 0.151653322012159 0.462817564527925 GO:0003995 acyl-CoA dehydrogenase activity 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0004126 cytidine deaminase activity 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0004300 enoyl-CoA hydratase activity 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0004875 complement receptor activity 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0016801 hydrolase activity, acting on ether bonds 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0016803 ether hydrolase activity 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0097677 STAT family protein binding 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/2150 12/18639 0.25 2.16732558139535 0.152895088281546 0.462817564527925 GO:0030291 protein serine/threonine kinase inhibitor activity 8/2150 46/18639 0.173913043478261 1.50770475227503 0.154473448075031 0.46644923536382 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 7/2150 39/18639 0.179487179487179 1.55602862254025 0.156344455223912 0.47094466708034 GO:0016836 hydro-lyase activity 10/2150 61/18639 0.163934426229508 1.42119710255433 0.16016391723805 0.480426188345141 GO:0008237 metallopeptidase activity 26/2150 184/18639 0.141304347826087 1.22501011122346 0.160272048222283 0.480426188345141 GO:0008080 N-acetyltransferase activity 11/2150 69/18639 0.159420289855072 1.38206268958544 0.167034437654981 0.496970854197929 GO:0043495 protein-membrane adaptor activity 8/2150 47/18639 0.170212765957447 1.47562592775854 0.168559577399863 0.496970854197929 GO:0061733 protein-lysine-acetyltransferase activity 8/2150 47/18639 0.170212765957447 1.47562592775854 0.168559577399863 0.496970854197929 GO:0003756 protein disulfide isomerase activity 4/2150 19/18639 0.210526315789474 1.82511627906977 0.168615111245726 0.496970854197929 GO:0015245 fatty acid transmembrane transporter activity 4/2150 19/18639 0.210526315789474 1.82511627906977 0.168615111245726 0.496970854197929 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4/2150 19/18639 0.210526315789474 1.82511627906977 0.168615111245726 0.496970854197929 GO:0043395 heparan sulfate proteoglycan binding 4/2150 19/18639 0.210526315789474 1.82511627906977 0.168615111245726 0.496970854197929 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 7/2150 40/18639 0.175 1.51712790697674 0.171874378137446 0.504164842536508 GO:0050997 quaternary ammonium group binding 7/2150 40/18639 0.175 1.51712790697674 0.171874378137446 0.504164842536508 GO:0005227 calcium-activated cation channel activity 5/2150 26/18639 0.192307692307692 1.66717352415027 0.173619090273895 0.506560733541035 GO:0034237 protein kinase A regulatory subunit binding 5/2150 26/18639 0.192307692307692 1.66717352415027 0.173619090273895 0.506560733541035 GO:0030296 protein tyrosine kinase activator activity 6/2150 33/18639 0.181818181818182 1.57623678646934 0.173924667441443 0.506560733541035 GO:0005172 vascular endothelial growth factor receptor binding 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0017154 semaphorin receptor activity 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0032396 inhibitory MHC class I receptor activity 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0035673 oligopeptide transmembrane transporter activity 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0061459 L-arginine transmembrane transporter activity 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0140852 histone ubiquitin ligase activity 3/2150 13/18639 0.230769230769231 2.00060822898032 0.18263466157928 0.520846997837206 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 46/2150 349/18639 0.131805157593123 1.14265875924569 0.186272913037903 0.529995909613619 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 36/2150 268/18639 0.134328358208955 1.16453314821243 0.186972578279912 0.530760867375235 GO:0015175 neutral L-amino acid transmembrane transporter activity 7/2150 41/18639 0.170731707317073 1.48012478729438 0.188039726145727 0.5325630864633 GO:0015035 protein-disulfide reductase activity 6/2150 34/18639 0.176470588235294 1.52987688098495 0.192002730389408 0.541298315422772 GO:0052866 phosphatidylinositol phosphate phosphatase activity 6/2150 34/18639 0.176470588235294 1.52987688098495 0.192002730389408 0.541298315422772 GO:0022804 active transmembrane transporter activity 59/2150 457/18639 0.12910284463895 1.11923159126762 0.194139812371774 0.545039552600661 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 5/2150 27/18639 0.185185185185185 1.60542635658915 0.194214580837411 0.545039552600661 GO:0060590 ATPase regulator activity 8/2150 49/18639 0.163265306122449 1.41539629805411 0.198373128752871 0.555444760508037 GO:0008081 phosphoric diester hydrolase activity 13/2150 87/18639 0.149425287356322 1.29541299117883 0.199465011119323 0.557235586619061 GO:0003823 antigen binding 24/2150 174/18639 0.137931034482759 1.19576583801123 0.203823942631434 0.568124654574495 GO:0004402 histone acetyltransferase activity 7/2150 42/18639 0.166666666666667 1.44488372093023 0.204794266358234 0.568257964309333 GO:0042056 chemoattractant activity 7/2150 42/18639 0.166666666666667 1.44488372093023 0.204794266358234 0.568257964309333 GO:0004623 phospholipase A2 activity 6/2150 35/18639 0.171428571428571 1.48616611295681 0.210755238154913 0.581033664272617 GO:0008494 translation activator activity 3/2150 14/18639 0.214285714285714 1.85770764119601 0.213730097913893 0.581033664272617 GO:0016530 metallochaperone activity 3/2150 14/18639 0.214285714285714 1.85770764119601 0.213730097913893 0.581033664272617 GO:0019763 immunoglobulin receptor activity 3/2150 14/18639 0.214285714285714 1.85770764119601 0.213730097913893 0.581033664272617 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/2150 14/18639 0.214285714285714 1.85770764119601 0.213730097913893 0.581033664272617 GO:0030983 mismatched DNA binding 3/2150 14/18639 0.214285714285714 1.85770764119601 0.213730097913893 0.581033664272617 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/2150 14/18639 0.214285714285714 1.85770764119601 0.213730097913893 0.581033664272617 GO:1901474 azole transmembrane transporter activity 3/2150 14/18639 0.214285714285714 1.85770764119601 0.213730097913893 0.581033664272617 GO:0036408 histone H3K14 acetyltransferase activity 5/2150 28/18639 0.178571428571429 1.54808970099668 0.215605503159508 0.581033664272617 GO:0046875 ephrin receptor binding 5/2150 28/18639 0.178571428571429 1.54808970099668 0.215605503159508 0.581033664272617 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/2150 28/18639 0.178571428571429 1.54808970099668 0.215605503159508 0.581033664272617 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/2150 21/18639 0.19047619047619 1.65129568106312 0.217887624102232 0.581033664272617 GO:0009931 calcium-dependent protein serine/threonine kinase activity 4/2150 21/18639 0.19047619047619 1.65129568106312 0.217887624102232 0.581033664272617 GO:0010314 phosphatidylinositol-5-phosphate binding 4/2150 21/18639 0.19047619047619 1.65129568106312 0.217887624102232 0.581033664272617 GO:0015174 basic amino acid transmembrane transporter activity 4/2150 21/18639 0.19047619047619 1.65129568106312 0.217887624102232 0.581033664272617 GO:0019200 carbohydrate kinase activity 4/2150 21/18639 0.19047619047619 1.65129568106312 0.217887624102232 0.581033664272617 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/2150 21/18639 0.19047619047619 1.65129568106312 0.217887624102232 0.581033664272617 GO:0140312 cargo adaptor activity 4/2150 21/18639 0.19047619047619 1.65129568106312 0.217887624102232 0.581033664272617 GO:0044325 transmembrane transporter binding 19/2150 136/18639 0.139705882352941 1.21115253077975 0.219884564999884 0.584533545971634 GO:0030971 receptor tyrosine kinase binding 12/2150 81/18639 0.148148148148148 1.28434108527132 0.220148997833472 0.584533545971634 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 9/2150 58/18639 0.155172413793103 1.34523656776263 0.220864162211456 0.585171285687126 GO:0051015 actin filament binding 28/2150 209/18639 0.133971291866029 1.16143763213531 0.226264743129037 0.59819348398063 GO:0008194 UDP-glycosyltransferase activity 20/2150 145/18639 0.137931034482759 1.19576583801123 0.22966479350665 0.605882281799129 GO:1901681 sulfur compound binding 36/2150 275/18639 0.130909090909091 1.13489048625793 0.232635865315458 0.609371873192054 GO:0004879 nuclear receptor activity 9/2150 59/18639 0.152542372881356 1.32243594797004 0.235987042520716 0.609371873192054 GO:0010484 histone H3 acetyltransferase activity 5/2150 29/18639 0.172413793103448 1.49470729751403 0.237685281146448 0.609371873192054 GO:0043236 laminin binding 5/2150 29/18639 0.172413793103448 1.49470729751403 0.237685281146448 0.609371873192054 GO:0141108 transporter regulator activity 23/2150 170/18639 0.135294117647059 1.17290560875513 0.237950661935292 0.609371873192054 GO:0001046 core promoter sequence-specific DNA binding 7/2150 44/18639 0.159090909090909 1.37920718816068 0.239871564362296 0.609371873192054 GO:0043014 alpha-tubulin binding 7/2150 44/18639 0.159090909090909 1.37920718816068 0.239871564362296 0.609371873192054 GO:0016881 acid-amino acid ligase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0032931 histone H3K56 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0033691 sialic acid binding 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0043992 histone H3K9 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0043993 histone H3K18 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0043994 histone H3K23 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0043999 histone H2AK5 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0044012 histone H2AK9 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0044014 histone H2BK5 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0044015 histone H2BK12 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0044016 histone H3K4 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0044017 histone H3K27 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0044018 histone H3K36 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0046972 histone H4K16 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0050321 tau-protein kinase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0140908 histone H3K122 acetyltransferase activity 4/2150 22/18639 0.181818181818182 1.57623678646934 0.243826217047226 0.609371873192054 GO:0031406 carboxylic acid binding 25/2150 187/18639 0.133689839572193 1.15899763710981 0.245139877628086 0.609371873192054 GO:0008135 translation factor activity, RNA binding 12/2150 83/18639 0.144578313253012 1.25339310731297 0.245738115810528 0.609371873192054 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/2150 15/18639 0.2 1.73386046511628 0.245826153389976 0.609371873192054 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/2150 15/18639 0.2 1.73386046511628 0.245826153389976 0.609371873192054 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 3/2150 15/18639 0.2 1.73386046511628 0.245826153389976 0.609371873192054 GO:0048531 beta-1,3-galactosyltransferase activity 3/2150 15/18639 0.2 1.73386046511628 0.245826153389976 0.609371873192054 GO:0120283 protein serine/threonine kinase binding 3/2150 15/18639 0.2 1.73386046511628 0.245826153389976 0.609371873192054 GO:0030295 protein kinase activator activity 19/2150 139/18639 0.136690647482014 1.18501254810105 0.249360728407607 0.616892404414 GO:0098531 ligand-modulated transcription factor activity 9/2150 60/18639 0.15 1.30039534883721 0.251466154294742 0.620854312807859 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 10/2150 68/18639 0.147058823529412 1.27489740082079 0.254880141967184 0.628024669807141 GO:0046915 transition metal ion transmembrane transporter activity 7/2150 45/18639 0.155555555555556 1.34855813953488 0.258089190927669 0.632634931229863 GO:0180051 translation factor activity 12/2150 84/18639 0.142857142857143 1.23847176079734 0.258929143205272 0.632634931229863 GO:0022839 monoatomic ion-gated channel activity 5/2150 30/18639 0.166666666666667 1.44488372093023 0.260345706277225 0.632634931229863 GO:0043995 histone H4K5 acetyltransferase activity 5/2150 30/18639 0.166666666666667 1.44488372093023 0.260345706277225 0.632634931229863 GO:0043996 histone H4K8 acetyltransferase activity 5/2150 30/18639 0.166666666666667 1.44488372093023 0.260345706277225 0.632634931229863 GO:0043997 histone H4K12 acetyltransferase activity 5/2150 30/18639 0.166666666666667 1.44488372093023 0.260345706277225 0.632634931229863 GO:0051721 protein phosphatase 2A binding 5/2150 30/18639 0.166666666666667 1.44488372093023 0.260345706277225 0.632634931229863 GO:0043177 organic acid binding 25/2150 189/18639 0.132275132275132 1.14673311184939 0.262572675579965 0.636790425815978 GO:0016251 RNA polymerase II general transcription initiation factor activity 8/2150 53/18639 0.150943396226415 1.30857393593681 0.263551388911841 0.637908273358327 GO:0042887 amide transmembrane transporter activity 6/2150 38/18639 0.157894736842105 1.36883720930233 0.270344965704289 0.649377617650137 GO:0004022 alcohol dehydrogenase (NAD+) activity 4/2150 23/18639 0.173913043478261 1.50770475227503 0.270398309946851 0.649377617650137 GO:0044013 histone H2B acetyltransferase activity 4/2150 23/18639 0.173913043478261 1.50770475227503 0.270398309946851 0.649377617650137 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/2150 23/18639 0.173913043478261 1.50770475227503 0.270398309946851 0.649377617650137 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/2150 46/18639 0.152173913043478 1.31924165824065 0.276686888362759 0.658778880532997 GO:0030276 clathrin binding 7/2150 46/18639 0.152173913043478 1.31924165824065 0.276686888362759 0.658778880532997 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/2150 16/18639 0.1875 1.62549418604651 0.278590744121503 0.658778880532997 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/2150 16/18639 0.1875 1.62549418604651 0.278590744121503 0.658778880532997 GO:0034450 ubiquitin-ubiquitin ligase activity 3/2150 16/18639 0.1875 1.62549418604651 0.278590744121503 0.658778880532997 GO:0055102 lipase inhibitor activity 3/2150 16/18639 0.1875 1.62549418604651 0.278590744121503 0.658778880532997 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/2150 16/18639 0.1875 1.62549418604651 0.278590744121503 0.658778880532997 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 3/2150 16/18639 0.1875 1.62549418604651 0.278590744121503 0.658778880532997 GO:0070325 lipoprotein particle receptor binding 5/2150 31/18639 0.161290322580645 1.39827456864216 0.283478510463357 0.669052729675969 GO:0015171 amino acid transmembrane transporter activity 14/2150 102/18639 0.137254901960784 1.18990424076607 0.28540925112346 0.670833230211225 GO:0016874 ligase activity 22/2150 167/18639 0.131736526946108 1.14206377941791 0.285809701498348 0.670833230211225 GO:0016410 N-acyltransferase activity 13/2150 94/18639 0.138297872340426 1.19894606630381 0.285866433328647 0.670833230211225 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/2150 39/18639 0.153846153846154 1.33373881932021 0.291072331246176 0.681751163679255 GO:0042826 histone deacetylase binding 17/2150 127/18639 0.133858267716535 1.16045779161326 0.294078266935294 0.684931177027525 GO:0001784 phosphotyrosine residue binding 7/2150 47/18639 0.148936170212766 1.29117268678872 0.295609167781265 0.684931177027525 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/2150 24/18639 0.166666666666667 1.44488372093023 0.297433587426726 0.684931177027525 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/2150 24/18639 0.166666666666667 1.44488372093023 0.297433587426726 0.684931177027525 GO:0004806 triacylglycerol lipase activity 4/2150 24/18639 0.166666666666667 1.44488372093023 0.297433587426726 0.684931177027525 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4/2150 24/18639 0.166666666666667 1.44488372093023 0.297433587426726 0.684931177027525 GO:0030552 cAMP binding 4/2150 24/18639 0.166666666666667 1.44488372093023 0.297433587426726 0.684931177027525 GO:0043998 histone H2A acetyltransferase activity 4/2150 24/18639 0.166666666666667 1.44488372093023 0.297433587426726 0.684931177027525 GO:0050699 WW domain binding 4/2150 24/18639 0.166666666666667 1.44488372093023 0.297433587426726 0.684931177027525 GO:0008017 microtubule binding 35/2150 276/18639 0.126811594202899 1.09936804853387 0.300452447872305 0.688666973261302 GO:0022884 macromolecule transmembrane transporter activity 5/2150 32/18639 0.15625 1.35457848837209 0.30697675895625 0.688666973261302 GO:0031369 translation initiation factor binding 5/2150 32/18639 0.15625 1.35457848837209 0.30697675895625 0.688666973261302 GO:0043425 bHLH transcription factor binding 5/2150 32/18639 0.15625 1.35457848837209 0.30697675895625 0.688666973261302 GO:0047498 calcium-dependent phospholipase A2 activity 5/2150 32/18639 0.15625 1.35457848837209 0.30697675895625 0.688666973261302 GO:0070717 poly-purine tract binding 5/2150 32/18639 0.15625 1.35457848837209 0.30697675895625 0.688666973261302 GO:0004550 nucleoside diphosphate kinase activity 3/2150 17/18639 0.176470588235294 1.52987688098495 0.311719020025654 0.688666973261302 GO:0004659 prenyltransferase activity 3/2150 17/18639 0.176470588235294 1.52987688098495 0.311719020025654 0.688666973261302 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/2150 17/18639 0.176470588235294 1.52987688098495 0.311719020025654 0.688666973261302 GO:0005092 GDP-dissociation inhibitor activity 3/2150 17/18639 0.176470588235294 1.52987688098495 0.311719020025654 0.688666973261302 GO:0016805 dipeptidase activity 3/2150 17/18639 0.176470588235294 1.52987688098495 0.311719020025654 0.688666973261302 GO:0031489 myosin V binding 3/2150 17/18639 0.176470588235294 1.52987688098495 0.311719020025654 0.688666973261302 GO:0038191 neuropilin binding 3/2150 17/18639 0.176470588235294 1.52987688098495 0.311719020025654 0.688666973261302 GO:0070492 oligosaccharide binding 3/2150 17/18639 0.176470588235294 1.52987688098495 0.311719020025654 0.688666973261302 GO:0030331 nuclear estrogen receptor binding 6/2150 40/18639 0.15 1.30039534883721 0.312107264147717 0.688666973261302 GO:0140693 molecular condensate scaffold activity 7/2150 48/18639 0.145833333333333 1.26427325581395 0.314800310818509 0.688666973261302 GO:0005518 collagen binding 10/2150 72/18639 0.138888888888889 1.20406976744186 0.31588310933781 0.688666973261302 GO:0042379 chemokine receptor binding 10/2150 72/18639 0.138888888888889 1.20406976744186 0.31588310933781 0.688666973261302 GO:0004536 DNA nuclease activity 9/2150 64/18639 0.140625 1.21912063953488 0.316272001631453 0.688666973261302 GO:0003697 single-stranded DNA binding 16/2150 121/18639 0.132231404958678 1.14635402652316 0.319409476693686 0.688666973261302 GO:0001094 TFIID-class transcription factor complex binding 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0005031 tumor necrosis factor receptor activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0005337 nucleoside transmembrane transporter activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0005381 iron ion transmembrane transporter activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0015203 polyamine transmembrane transporter activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0015279 store-operated calcium channel activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0030957 Tat protein binding 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0031419 cobalamin binding 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0033204 ribonuclease P RNA binding 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0035256 G protein-coupled glutamate receptor binding 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0050308 sugar-phosphatase activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0051864 histone H3K36 demethylase activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0051880 G-quadruplex DNA binding 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0140999 histone H3K4 trimethyltransferase activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0141109 transporter activator activity 2/2150 10/18639 0.2 1.73386046511628 0.323639736617829 0.688666973261302 GO:0003707 nuclear steroid receptor activity 4/2150 25/18639 0.16 1.38708837209302 0.324769083981182 0.688666973261302 GO:0005537 D-mannose binding 4/2150 25/18639 0.16 1.38708837209302 0.324769083981182 0.688666973261302 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4/2150 25/18639 0.16 1.38708837209302 0.324769083981182 0.688666973261302 GO:0042974 nuclear retinoic acid receptor binding 4/2150 25/18639 0.16 1.38708837209302 0.324769083981182 0.688666973261302 GO:0003727 single-stranded RNA binding 12/2150 89/18639 0.134831460674157 1.16889469558401 0.328058848190796 0.694447596170207 GO:0046943 carboxylic acid transmembrane transporter activity 24/2150 188/18639 0.127659574468085 1.1067194458189 0.329979365663369 0.697236848493695 GO:0140416 transcription regulator inhibitor activity 5/2150 33/18639 0.151515151515152 1.31353065539112 0.330736061012465 0.697236848493695 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 16/2150 122/18639 0.131147540983607 1.13695768204346 0.331532553869507 0.697236848493695 GO:0004521 RNA endonuclease activity 10/2150 73/18639 0.136986301369863 1.18757566103855 0.331640254234826 0.697236848493695 GO:0001727 lipid kinase activity 6/2150 41/18639 0.146341463414634 1.26867838910947 0.333375984948057 0.697865024258555 GO:0017080 sodium channel regulator activity 6/2150 41/18639 0.146341463414634 1.26867838910947 0.333375984948057 0.697865024258555 GO:0015932 nucleobase-containing compound transmembrane transporter activity 8/2150 57/18639 0.140350877192982 1.21674418604651 0.333954666987189 0.697865024258555 GO:0035254 glutamate receptor binding 7/2150 49/18639 0.142857142857143 1.23847176079734 0.334204841162782 0.697865024258555 GO:0005342 organic acid transmembrane transporter activity 24/2150 189/18639 0.126984126984127 1.10086378737542 0.339783975130045 0.708314479458909 GO:0008409 5'-3' exonuclease activity 3/2150 18/18639 0.166666666666667 1.44488372093023 0.34493565223077 0.711923984266749 GO:0015172 acidic amino acid transmembrane transporter activity 3/2150 18/18639 0.166666666666667 1.44488372093023 0.34493565223077 0.711923984266749 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/2150 18/18639 0.166666666666667 1.44488372093023 0.34493565223077 0.711923984266749 GO:1901611 phosphatidylglycerol binding 3/2150 18/18639 0.166666666666667 1.44488372093023 0.34493565223077 0.711923984266749 GO:1990381 ubiquitin-specific protease binding 3/2150 18/18639 0.166666666666667 1.44488372093023 0.34493565223077 0.711923984266749 GO:0017171 serine hydrolase activity 25/2150 198/18639 0.126262626262626 1.0946088794926 0.346246350357996 0.711923984266749 GO:0140030 modification-dependent protein binding 22/2150 173/18639 0.127167630057803 1.10245463099879 0.346378716913903 0.711923984266749 GO:0003684 damaged DNA binding 10/2150 74/18639 0.135135135135135 1.17152734129478 0.34754160021986 0.711923984266749 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0005160 transforming growth factor beta receptor binding 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0008143 poly(A) binding 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0030247 polysaccharide binding 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0030507 spectrin binding 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0050750 low-density lipoprotein particle receptor binding 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0052742 phosphatidylinositol kinase activity 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0070412 R-SMAD binding 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0097602 cullin family protein binding 4/2150 26/18639 0.153846153846154 1.33373881932021 0.352250901018871 0.711923984266749 GO:0005516 calmodulin binding 26/2150 207/18639 0.1256038647343 1.08889787664307 0.352403625596513 0.711923984266749 GO:0008376 acetylgalactosaminyltransferase activity 5/2150 34/18639 0.147058823529412 1.27489740082079 0.354655600775061 0.711923984266749 GO:0030332 cyclin binding 5/2150 34/18639 0.147058823529412 1.27489740082079 0.354655600775061 0.711923984266749 GO:0004520 DNA endonuclease activity 6/2150 42/18639 0.142857142857143 1.23847176079734 0.354806271379695 0.711923984266749 GO:0016859 cis-trans isomerase activity 6/2150 42/18639 0.142857142857143 1.23847176079734 0.354806271379695 0.711923984266749 GO:0051879 Hsp90 protein binding 6/2150 42/18639 0.142857142857143 1.23847176079734 0.354806271379695 0.711923984266749 GO:0015631 tubulin binding 47/2150 385/18639 0.122077922077922 1.05833041377227 0.36149319126957 0.714730634180989 GO:0016757 glycosyltransferase activity 33/2150 267/18639 0.123595505617978 1.07148680428534 0.363291611444908 0.714730634180989 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0003953 NAD+ nucleosidase activity 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0005114 type II transforming growth factor beta receptor binding 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0005536 D-glucose binding 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0008172 S-methyltransferase activity 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0008432 JUN kinase binding 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0015217 ADP transmembrane transporter activity 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0019203 carbohydrate phosphatase activity 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0019215 intermediate filament binding 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0034056 estrogen response element binding 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0048185 activin binding 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0140031 phosphorylation-dependent protein binding 2/2150 11/18639 0.181818181818182 1.57623678646934 0.36780781012236 0.714730634180989 GO:0005048 signal sequence binding 7/2150 51/18639 0.137254901960784 1.18990424076607 0.373435933715783 0.724524520217079 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2150 19/18639 0.157894736842105 1.36883720930233 0.377995753665465 0.725324200682504 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/2150 19/18639 0.157894736842105 1.36883720930233 0.377995753665465 0.725324200682504 GO:0031420 alkali metal ion binding 3/2150 19/18639 0.157894736842105 1.36883720930233 0.377995753665465 0.725324200682504 GO:0034987 immunoglobulin receptor binding 3/2150 19/18639 0.157894736842105 1.36883720930233 0.377995753665465 0.725324200682504 GO:0097001 ceramide binding 3/2150 19/18639 0.157894736842105 1.36883720930233 0.377995753665465 0.725324200682504 GO:0010485 histone H4 acetyltransferase activity 5/2150 35/18639 0.142857142857143 1.23847176079734 0.378638994545085 0.725324200682504 GO:0017022 myosin binding 10/2150 76/18639 0.131578947368421 1.1406976744186 0.379660198110951 0.725324200682504 GO:0004683 calcium/calmodulin-dependent protein kinase activity 4/2150 27/18639 0.148148148148148 1.28434108527132 0.379735478441733 0.725324200682504 GO:0008266 poly(U) RNA binding 4/2150 27/18639 0.148148148148148 1.28434108527132 0.379735478441733 0.725324200682504 GO:0035255 ionotropic glutamate receptor binding 4/2150 27/18639 0.148148148148148 1.28434108527132 0.379735478441733 0.725324200682504 GO:0016247 channel regulator activity 21/2150 168/18639 0.125 1.08366279069767 0.382017231708397 0.728552986787532 GO:0005548 phospholipid transporter activity 9/2150 68/18639 0.132352941176471 1.14740766073871 0.384027979963202 0.730127270547322 GO:0140223 general transcription initiation factor activity 9/2150 68/18639 0.132352941176471 1.14740766073871 0.384027979963202 0.730127270547322 GO:0051213 dioxygenase activity 12/2150 93/18639 0.129032258064516 1.11861965491373 0.38591594329854 0.732466180835593 GO:0099106 ion channel regulator activity 20/2150 160/18639 0.125 1.08366279069767 0.386447254499298 0.732466180835593 GO:0008236 serine-type peptidase activity 24/2150 194/18639 0.123711340206186 1.07249100935028 0.389752589332025 0.737596298090714 GO:0030159 signaling receptor complex adaptor activity 7/2150 52/18639 0.134615384615385 1.16702146690519 0.39315646112402 0.742371176083387 GO:0004519 endonuclease activity 16/2150 127/18639 0.125984251968504 1.09219556857718 0.393480826284458 0.742371176083387 GO:0001223 transcription coactivator binding 6/2150 44/18639 0.136363636363636 1.18217758985201 0.397873787302189 0.746089050161791 GO:0003954 NADH dehydrogenase activity 6/2150 44/18639 0.136363636363636 1.18217758985201 0.397873787302189 0.746089050161791 GO:0019205 nucleobase-containing compound kinase activity 6/2150 44/18639 0.136363636363636 1.18217758985201 0.397873787302189 0.746089050161791 GO:0030547 signaling receptor inhibitor activity 6/2150 44/18639 0.136363636363636 1.18217758985201 0.397873787302189 0.746089050161791 GO:0005319 lipid transporter activity 22/2150 178/18639 0.123595505617978 1.07148680428534 0.398905589654091 0.746450909634696 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/2150 36/18639 0.138888888888889 1.20406976744186 0.402594983427339 0.746450909634696 GO:0051959 dynein light intermediate chain binding 4/2150 28/18639 0.142857142857143 1.23847176079734 0.407090474322104 0.746450909634696 GO:0001972 retinoic acid binding 3/2150 20/18639 0.15 1.30039534883721 0.410684772328955 0.746450909634696 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 3/2150 20/18639 0.15 1.30039534883721 0.410684772328955 0.746450909634696 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/2150 20/18639 0.15 1.30039534883721 0.410684772328955 0.746450909634696 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0004526 ribonuclease P activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0004859 phospholipase inhibitor activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0005025 transforming growth factor beta receptor activity, type I 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0005026 transforming growth factor beta receptor activity, type II 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0005095 GTPase inhibitor activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0005165 neurotrophin receptor binding 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0015269 calcium-activated potassium channel activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0016361 activin receptor activity, type I 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0016362 activin receptor activity, type II 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0017002 activin receptor activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0017166 vinculin binding 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0035251 UDP-glucosyltransferase activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2150 12/18639 0.166666666666667 1.44488372093023 0.410790354490522 0.746450909634696 GO:0008146 sulfotransferase activity 7/2150 53/18639 0.132075471698113 1.14500219394471 0.412878972112829 0.746941106671079 GO:0016860 intramolecular oxidoreductase activity 7/2150 53/18639 0.132075471698113 1.14500219394471 0.412878972112829 0.746941106671079 GO:0140296 general transcription initiation factor binding 7/2150 53/18639 0.132075471698113 1.14500219394471 0.412878972112829 0.746941106671079 GO:0004867 serine-type endopeptidase inhibitor activity 12/2150 95/18639 0.126315789473684 1.09506976744186 0.41522748185034 0.750088354310291 GO:0016782 transferase activity, transferring sulphur-containing groups 9/2150 70/18639 0.128571428571429 1.11462458471761 0.418318173664441 0.754565139025756 GO:0008009 chemokine activity 6/2150 45/18639 0.133333333333333 1.15590697674419 0.419379109821346 0.755372899561254 GO:0016853 isomerase activity 22/2150 180/18639 0.122222222222222 1.05958139534884 0.42019989870246 0.755746387155374 GO:0030551 cyclic nucleotide binding 5/2150 37/18639 0.135135135135135 1.17152734129478 0.426437972362036 0.765847787099167 GO:0016835 carbon-oxygen lyase activity 10/2150 79/18639 0.126582278481013 1.09738004121283 0.428198944996831 0.767890975598393 GO:0005416 amino acid:monoatomic cation symporter activity 4/2150 29/18639 0.137931034482759 1.19576583801123 0.434195305230209 0.776384058118457 GO:0035250 UDP-galactosyltransferase activity 4/2150 29/18639 0.137931034482759 1.19576583801123 0.434195305230209 0.776384058118457 GO:0051010 microtubule plus-end binding 3/2150 21/18639 0.142857142857143 1.23847176079734 0.442817630366743 0.790198411937928 GO:1901682 sulfur compound transmembrane transporter activity 8/2150 63/18639 0.126984126984127 1.10086378737542 0.443369150924825 0.790198411937928 GO:0005262 calcium channel activity 16/2150 131/18639 0.122137404580153 1.05884608556719 0.4438452119002 0.790198411937928 GO:0005501 retinoid binding 5/2150 38/18639 0.131578947368421 1.1406976744186 0.45008842791624 0.792603971471468 GO:0019840 isoprenoid binding 5/2150 38/18639 0.131578947368421 1.1406976744186 0.45008842791624 0.792603971471468 GO:0004465 lipoprotein lipase activity 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0005035 death receptor activity 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0008253 5'-nucleotidase activity 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0019104 DNA N-glycosylase activity 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0019855 calcium channel inhibitor activity 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0030955 potassium ion binding 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0051011 microtubule minus-end binding 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0070123 transforming growth factor beta receptor activity, type III 2/2150 13/18639 0.153846153846154 1.33373881932021 0.452273207747112 0.792603971471468 GO:0004518 nuclease activity 25/2150 209/18639 0.119617224880383 1.0369978858351 0.455215357822489 0.796626876189355 GO:0008187 poly-pyrimidine tract binding 4/2150 30/18639 0.133333333333333 1.15590697674419 0.460941397376822 0.803224613250699 GO:0035925 mRNA 3'-UTR AU-rich region binding 4/2150 30/18639 0.133333333333333 1.15590697674419 0.460941397376822 0.803224613250699 GO:0048019 receptor antagonist activity 4/2150 30/18639 0.133333333333333 1.15590697674419 0.460941397376822 0.803224613250699 GO:0030170 pyridoxal phosphate binding 7/2150 56/18639 0.125 1.08366279069767 0.471584175365682 0.818291858709542 GO:0004407 histone deacetylase activity 3/2150 22/18639 0.136363636363636 1.18217758985201 0.474237327206666 0.818291858709542 GO:0008093 cytoskeletal anchor activity 3/2150 22/18639 0.136363636363636 1.18217758985201 0.474237327206666 0.818291858709542 GO:0031683 G-protein beta/gamma-subunit complex binding 3/2150 22/18639 0.136363636363636 1.18217758985201 0.474237327206666 0.818291858709542 GO:0033558 protein lysine deacetylase activity 3/2150 22/18639 0.136363636363636 1.18217758985201 0.474237327206666 0.818291858709542 GO:0070034 telomerase RNA binding 3/2150 22/18639 0.136363636363636 1.18217758985201 0.474237327206666 0.818291858709542 GO:0140035 ubiquitin-like protein reader activity 3/2150 22/18639 0.136363636363636 1.18217758985201 0.474237327206666 0.818291858709542 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/2150 48/18639 0.125 1.08366279069767 0.483060396467006 0.832350221604688 GO:0008327 methyl-CpG binding 4/2150 31/18639 0.129032258064516 1.11861965491373 0.487232195438076 0.833812164828332 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2150 31/18639 0.129032258064516 1.11861965491373 0.487232195438076 0.833812164828332 GO:0046906 tetrapyrrole binding 18/2150 152/18639 0.118421052631579 1.02662790697674 0.49044177109484 0.833812164828332 GO:0070279 vitamin B6 binding 7/2150 57/18639 0.12280701754386 1.0646511627907 0.490852306538672 0.833812164828332 GO:0005161 platelet-derived growth factor receptor binding 2/2150 14/18639 0.142857142857143 1.23847176079734 0.492030392719316 0.833812164828332 GO:0005313 L-glutamate transmembrane transporter activity 2/2150 14/18639 0.142857142857143 1.23847176079734 0.492030392719316 0.833812164828332 GO:0005347 ATP transmembrane transporter activity 2/2150 14/18639 0.142857142857143 1.23847176079734 0.492030392719316 0.833812164828332 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2150 14/18639 0.142857142857143 1.23847176079734 0.492030392719316 0.833812164828332 GO:0031404 chloride ion binding 2/2150 14/18639 0.142857142857143 1.23847176079734 0.492030392719316 0.833812164828332 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2150 14/18639 0.142857142857143 1.23847176079734 0.492030392719316 0.833812164828332 GO:0042043 neurexin family protein binding 2/2150 14/18639 0.142857142857143 1.23847176079734 0.492030392719316 0.833812164828332 GO:0098821 BMP receptor activity 2/2150 14/18639 0.142857142857143 1.23847176079734 0.492030392719316 0.833812164828332 GO:0045296 cadherin binding 39/2150 334/18639 0.116766467065868 1.01228380448406 0.493289659510664 0.834797885325739 GO:0005178 integrin binding 19/2150 161/18639 0.118012422360248 1.0230853676152 0.494495405777487 0.835690452562227 GO:0005283 amino acid:sodium symporter activity 3/2150 23/18639 0.130434782608696 1.13077856420627 0.504813179795639 0.848471811061701 GO:0043274 phospholipase binding 3/2150 23/18639 0.130434782608696 1.13077856420627 0.504813179795639 0.848471811061701 GO:0070577 lysine-acetylated histone binding 3/2150 23/18639 0.130434782608696 1.13077856420627 0.504813179795639 0.848471811061701 GO:0140103 catalytic activity, acting on a glycoprotein 3/2150 23/18639 0.130434782608696 1.13077856420627 0.504813179795639 0.848471811061701 GO:0016779 nucleotidyltransferase activity 16/2150 136/18639 0.117647058823529 1.01991792065663 0.50646058431639 0.850080980759935 GO:0051219 phosphoprotein binding 11/2150 93/18639 0.118279569892473 1.02540135033758 0.512862764487035 0.855102137357346 GO:0008378 galactosyltransferase activity 4/2150 32/18639 0.125 1.08366279069767 0.512982972078337 0.855102137357346 GO:0042910 xenobiotic transmembrane transporter activity 4/2150 32/18639 0.125 1.08366279069767 0.512982972078337 0.855102137357346 GO:0005506 iron ion binding 18/2150 154/18639 0.116883116883117 1.01329507701601 0.51383486025915 0.855102137357346 GO:0031490 chromatin DNA binding 15/2150 128/18639 0.1171875 1.01593386627907 0.515207118064321 0.855102137357346 GO:0016922 nuclear receptor binding 16/2150 137/18639 0.116788321167883 1.01247326430148 0.518818179859141 0.855102137357346 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/2150 41/18639 0.121951219512195 1.05723199092456 0.519185060498449 0.855102137357346 GO:0140318 protein transporter activity 5/2150 41/18639 0.121951219512195 1.05723199092456 0.519185060498449 0.855102137357346 GO:0015605 organophosphate ester transmembrane transporter activity 6/2150 50/18639 0.12 1.04031627906977 0.524294072762221 0.855102137357346 GO:0048020 CCR chemokine receptor binding 6/2150 50/18639 0.12 1.04031627906977 0.524294072762221 0.855102137357346 GO:0015459 potassium channel regulator activity 7/2150 59/18639 0.11864406779661 1.02856129286559 0.528702590993181 0.855102137357346 GO:0045309 protein phosphorylated amino acid binding 7/2150 59/18639 0.11864406779661 1.02856129286559 0.528702590993181 0.855102137357346 GO:0004129 cytochrome-c oxidase activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0005523 tropomyosin binding 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0008242 omega peptidase activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0008252 nucleotidase activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0010181 FMN binding 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0015116 sulfate transmembrane transporter activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0031386 protein tag activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0034483 heparan sulfate sulfotransferase activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0050780 dopamine receptor binding 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0051371 muscle alpha-actinin binding 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0141047 molecular tag activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0141050 histone H3K deacetylase activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0141051 histone H4K deacetylase activity 2/2150 15/18639 0.133333333333333 1.15590697674419 0.529907968000753 0.855102137357346 GO:0015085 calcium ion transmembrane transporter activity 17/2150 147/18639 0.115646258503401 1.00257237778832 0.534105800949482 0.855102137357346 GO:0001091 RNA polymerase II general transcription initiation factor binding 3/2150 24/18639 0.125 1.08366279069767 0.534438835848341 0.855102137357346 GO:0019957 C-C chemokine binding 3/2150 24/18639 0.125 1.08366279069767 0.534438835848341 0.855102137357346 GO:0030215 semaphorin receptor binding 3/2150 24/18639 0.125 1.08366279069767 0.534438835848341 0.855102137357346 GO:0035035 histone acetyltransferase binding 3/2150 24/18639 0.125 1.08366279069767 0.534438835848341 0.855102137357346 GO:0050431 transforming growth factor beta binding 3/2150 24/18639 0.125 1.08366279069767 0.534438835848341 0.855102137357346 GO:0140033 acetylation-dependent protein binding 3/2150 24/18639 0.125 1.08366279069767 0.534438835848341 0.855102137357346 GO:0140612 DNA damage sensor activity 3/2150 24/18639 0.125 1.08366279069767 0.534438835848341 0.855102137357346 GO:0004540 RNA nuclease activity 14/2150 121/18639 0.115702479338843 1.00305977320776 0.537619362457649 0.858762212084484 GO:0019956 chemokine binding 4/2150 33/18639 0.121212121212121 1.0508245243129 0.53812047705294 0.858762212084484 GO:0002039 p53 binding 8/2150 69/18639 0.115942028985507 1.00513650151668 0.54986015589218 0.87636185259918 GO:0004713 protein tyrosine kinase activity 16/2150 140/18639 0.114285714285714 0.990777408637874 0.555362669475332 0.881262260404141 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/2150 34/18639 0.117647058823529 1.01991792065663 0.562582460556657 0.881262260404141 GO:0051427 hormone receptor binding 4/2150 34/18639 0.117647058823529 1.01991792065663 0.562582460556657 0.881262260404141 GO:0008139 nuclear localization sequence binding 3/2150 25/18639 0.12 1.04031627906977 0.563030165648408 0.881262260404141 GO:0015662 P-type ion transporter activity 3/2150 25/18639 0.12 1.04031627906977 0.563030165648408 0.881262260404141 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/2150 25/18639 0.12 1.04031627906977 0.563030165648408 0.881262260404141 GO:0017025 TBP-class protein binding 3/2150 25/18639 0.12 1.04031627906977 0.563030165648408 0.881262260404141 GO:0019211 phosphatase activator activity 3/2150 25/18639 0.12 1.04031627906977 0.563030165648408 0.881262260404141 GO:0140358 P-type transmembrane transporter activity 3/2150 25/18639 0.12 1.04031627906977 0.563030165648408 0.881262260404141 GO:0015026 coreceptor activity 7/2150 61/18639 0.114754098360656 0.994837971788029 0.56541360992328 0.881262260404141 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/2150 16/18639 0.125 1.08366279069767 0.565810428554931 0.881262260404141 GO:0004707 MAP kinase activity 2/2150 16/18639 0.125 1.08366279069767 0.565810428554931 0.881262260404141 GO:0004708 MAP kinase kinase activity 2/2150 16/18639 0.125 1.08366279069767 0.565810428554931 0.881262260404141 GO:0005024 transforming growth factor beta receptor activity 2/2150 16/18639 0.125 1.08366279069767 0.565810428554931 0.881262260404141 GO:0005159 insulin-like growth factor receptor binding 2/2150 16/18639 0.125 1.08366279069767 0.565810428554931 0.881262260404141 GO:0008142 oxysterol binding 2/2150 16/18639 0.125 1.08366279069767 0.565810428554931 0.881262260404141 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/2150 16/18639 0.125 1.08366279069767 0.565810428554931 0.881262260404141 GO:0019841 retinol binding 2/2150 16/18639 0.125 1.08366279069767 0.565810428554931 0.881262260404141 GO:0008028 monocarboxylic acid transmembrane transporter activity 8/2150 70/18639 0.114285714285714 0.990777408637874 0.566833314889307 0.881740712050034 GO:0001221 transcription coregulator binding 13/2150 115/18639 0.11304347826087 0.980008088978766 0.574567461319635 0.892644530070353 GO:0020037 heme binding 16/2150 142/18639 0.112676056338028 0.976822797248608 0.579186488798495 0.898687347858622 GO:0005246 calcium channel regulator activity 6/2150 53/18639 0.113207547169811 0.981430451952611 0.583446554619349 0.904158685900677 GO:0043015 gamma-tubulin binding 4/2150 35/18639 0.114285714285714 0.990777408637874 0.586317101332344 0.907137749966608 GO:0001637 G protein-coupled chemoattractant receptor activity 3/2150 26/18639 0.115384615384615 1.00030411449016 0.590523113208782 0.907137749966608 GO:0004529 DNA exonuclease activity 3/2150 26/18639 0.115384615384615 1.00030411449016 0.590523113208782 0.907137749966608 GO:0004950 chemokine receptor activity 3/2150 26/18639 0.115384615384615 1.00030411449016 0.590523113208782 0.907137749966608 GO:0008157 protein phosphatase 1 binding 3/2150 26/18639 0.115384615384615 1.00030411449016 0.590523113208782 0.907137749966608 GO:0043548 phosphatidylinositol 3-kinase binding 3/2150 26/18639 0.115384615384615 1.00030411449016 0.590523113208782 0.907137749966608 GO:0050681 nuclear androgen receptor binding 3/2150 26/18639 0.115384615384615 1.00030411449016 0.590523113208782 0.907137749966608 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/2150 17/18639 0.117647058823529 1.01991792065663 0.599689283025502 0.914377718672547 GO:0015278 intracellularly gated calcium channel activity 2/2150 17/18639 0.117647058823529 1.01991792065663 0.599689283025502 0.914377718672547 GO:0019198 transmembrane receptor protein phosphatase activity 2/2150 17/18639 0.117647058823529 1.01991792065663 0.599689283025502 0.914377718672547 GO:0032183 SUMO binding 2/2150 17/18639 0.117647058823529 1.01991792065663 0.599689283025502 0.914377718672547 GO:0045125 bioactive lipid receptor activity 2/2150 17/18639 0.117647058823529 1.01991792065663 0.599689283025502 0.914377718672547 GO:0051787 misfolded protein binding 2/2150 17/18639 0.117647058823529 1.01991792065663 0.599689283025502 0.914377718672547 GO:0015297 antiporter activity 15/2150 135/18639 0.111111111111111 0.963255813953488 0.601745621613645 0.916378993606935 GO:0008083 growth factor activity 18/2150 162/18639 0.111111111111111 0.963255813953488 0.604136097482613 0.918883545800716 GO:0008514 organic anion transmembrane transporter activity 30/2150 269/18639 0.111524163568773 0.966836690585286 0.607098783539557 0.922157094593144 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/2150 36/18639 0.111111111111111 0.963255813953488 0.60928236607047 0.922157094593144 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/2150 36/18639 0.111111111111111 0.963255813953488 0.60928236607047 0.922157094593144 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/2150 36/18639 0.111111111111111 0.963255813953488 0.60928236607047 0.922157094593144 GO:0008320 protein transmembrane transporter activity 3/2150 27/18639 0.111111111111111 0.963255813953488 0.616871567554664 0.932497878806559 GO:0030165 PDZ domain binding 9/2150 83/18639 0.108433734939759 0.94004483048473 0.629516997751049 0.946531941398792 GO:0019213 deacetylase activity 4/2150 37/18639 0.108108108108108 0.937221873035827 0.631445322883613 0.946531941398792 GO:0042805 actinin binding 4/2150 37/18639 0.108108108108108 0.937221873035827 0.631445322883613 0.946531941398792 GO:0000900 mRNA regulatory element binding translation repressor activity 2/2150 18/18639 0.111111111111111 0.963255813953488 0.631533486874843 0.946531941398792 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/2150 18/18639 0.111111111111111 0.963255813953488 0.631533486874843 0.946531941398792 GO:0098641 cadherin binding involved in cell-cell adhesion 2/2150 18/18639 0.111111111111111 0.963255813953488 0.631533486874843 0.946531941398792 GO:0099602 neurotransmitter receptor regulator activity 2/2150 18/18639 0.111111111111111 0.963255813953488 0.631533486874843 0.946531941398792 GO:0170055 lipid transmembrane transporter activity 6/2150 56/18639 0.107142857142857 0.928853820598007 0.638589623867389 0.955944613128339 GO:0046625 sphingolipid binding 3/2150 28/18639 0.107142857142857 0.928853820598007 0.642045298742571 0.956468933556042 GO:0046966 nuclear thyroid hormone receptor binding 3/2150 28/18639 0.107142857142857 0.928853820598007 0.642045298742571 0.956468933556042 GO:0051393 alpha-actinin binding 3/2150 28/18639 0.107142857142857 0.928853820598007 0.642045298742571 0.956468933556042 GO:0141052 histone H3 demethylase activity 3/2150 28/18639 0.107142857142857 0.928853820598007 0.642045298742571 0.956468933556042 GO:0140359 ABC-type transporter activity 5/2150 47/18639 0.106382978723404 0.922266204849085 0.644329255946077 0.95871212962025 GO:0005200 structural constituent of cytoskeleton 12/2150 112/18639 0.107142857142857 0.928853820598007 0.651387776149739 0.96804552498972 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2150 19/18639 0.105263157894737 0.912558139534884 0.661361455487711 0.973473492426356 GO:0005520 insulin-like growth factor binding 2/2150 19/18639 0.105263157894737 0.912558139534884 0.661361455487711 0.973473492426356 GO:0008301 DNA binding, bending 2/2150 19/18639 0.105263157894737 0.912558139534884 0.661361455487711 0.973473492426356 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/2150 19/18639 0.105263157894737 0.912558139534884 0.661361455487711 0.973473492426356 GO:0016918 retinal binding 2/2150 19/18639 0.105263157894737 0.912558139534884 0.661361455487711 0.973473492426356 GO:0042800 histone H3K4 methyltransferase activity 2/2150 19/18639 0.105263157894737 0.912558139534884 0.661361455487711 0.973473492426356 GO:0046527 glucosyltransferase activity 2/2150 19/18639 0.105263157894737 0.912558139534884 0.661361455487711 0.973473492426356 GO:0050145 nucleoside monophosphate kinase activity 2/2150 19/18639 0.105263157894737 0.912558139534884 0.661361455487711 0.973473492426356 GO:0043021 ribonucleoprotein complex binding 19/2150 177/18639 0.107344632768362 0.930603074497438 0.666025130207141 0.974520764906985 GO:0004181 metallocarboxypeptidase activity 3/2150 29/18639 0.103448275862069 0.89682437850842 0.666027990301689 0.974520764906985 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/2150 29/18639 0.103448275862069 0.89682437850842 0.666027990301689 0.974520764906985 GO:0097472 cyclin-dependent protein kinase activity 3/2150 29/18639 0.103448275862069 0.89682437850842 0.666027990301689 0.974520764906985 GO:0099604 ligand-gated calcium channel activity 3/2150 29/18639 0.103448275862069 0.89682437850842 0.666027990301689 0.974520764906985 GO:0019842 vitamin binding 16/2150 150/18639 0.106666666666667 0.924725581395349 0.668721862804158 0.977301702223871 GO:0061980 regulatory RNA binding 6/2150 58/18639 0.103448275862069 0.89682437850842 0.672824342141865 0.978012498679286 GO:0000217 DNA secondary structure binding 4/2150 39/18639 0.102564102564103 0.889159212880143 0.67327380304922 0.978012498679286 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/2150 39/18639 0.102564102564103 0.889159212880143 0.67327380304922 0.978012498679286 GO:0001222 transcription corepressor binding 5/2150 49/18639 0.102040816326531 0.884622686283816 0.681178097754346 0.978012498679286 GO:1990841 promoter-specific chromatin binding 7/2150 68/18639 0.102941176470588 0.892428180574555 0.682018628572041 0.978012498679286 GO:0016758 hexosyltransferase activity 21/2150 197/18639 0.106598984771574 0.924138826584819 0.683314156397746 0.978012498679286 GO:0015215 nucleotide transmembrane transporter activity 3/2150 30/18639 0.1 0.86693023255814 0.688815389515564 0.978012498679286 GO:0032452 histone demethylase activity 3/2150 30/18639 0.1 0.86693023255814 0.688815389515564 0.978012498679286 GO:0070566 adenylyltransferase activity 3/2150 30/18639 0.1 0.86693023255814 0.688815389515564 0.978012498679286 GO:0070063 RNA polymerase binding 6/2150 59/18639 0.101694915254237 0.881623965313362 0.689140012083226 0.978012498679286 GO:0000339 RNA cap binding 2/2150 20/18639 0.1 0.86693023255814 0.689214420283128 0.978012498679286 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/2150 20/18639 0.1 0.86693023255814 0.689214420283128 0.978012498679286 GO:0005326 neurotransmitter transmembrane transporter activity 2/2150 20/18639 0.1 0.86693023255814 0.689214420283128 0.978012498679286 GO:0031418 L-ascorbic acid binding 2/2150 20/18639 0.1 0.86693023255814 0.689214420283128 0.978012498679286 GO:0052745 inositol phosphate phosphatase activity 2/2150 20/18639 0.1 0.86693023255814 0.689214420283128 0.978012498679286 GO:0140664 ATP-dependent DNA damage sensor activity 2/2150 20/18639 0.1 0.86693023255814 0.689214420283128 0.978012498679286 GO:0015144 carbohydrate transmembrane transporter activity 4/2150 40/18639 0.1 0.86693023255814 0.69291251259484 0.978012498679286 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/2150 60/18639 0.1 0.86693023255814 0.704909354584338 0.978012498679286 GO:0008201 heparin binding 18/2150 172/18639 0.104651162790698 0.907252568956193 0.705384028868591 0.978012498679286 GO:0000182 rDNA binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0003796 lysozyme activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0004955 prostaglandin receptor activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0005522 profilin binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0008140 cAMP response element binding protein binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0008190 eukaryotic initiation factor 4E binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0015187 glycine transmembrane transporter activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0015643 toxic substance binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0016783 sulfurtransferase activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0031996 thioesterase binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0032052 bile acid binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0043208 glycosphingolipid binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0070739 protein-glutamic acid ligase activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0070740 tubulin-glutamic acid ligase activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0071723 lipopeptide binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0097177 mitochondrial ribosome binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0098505 G-rich strand telomeric DNA binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:1990757 ubiquitin ligase activator activity 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:1990763 arrestin family protein binding 1/2150 10/18639 0.1 0.86693023255814 0.706518769338121 0.978012498679286 GO:0019208 phosphatase regulator activity 12/2150 117/18639 0.102564102564103 0.889159212880143 0.710274195200888 0.981199037557626 GO:0140457 protein demethylase activity 3/2150 31/18639 0.0967741935483871 0.838964741185296 0.710413588881009 0.981199037557626 GO:0097110 scaffold protein binding 7/2150 70/18639 0.1 0.86693023255814 0.711396016629245 0.981455646682228 GO:0008373 sialyltransferase activity 2/2150 21/18639 0.0952380952380952 0.825647840531561 0.715150924484853 0.982236275323678 GO:0035613 RNA stem-loop binding 2/2150 21/18639 0.0952380952380952 0.825647840531561 0.715150924484853 0.982236275323678 GO:0036122 BMP binding 2/2150 21/18639 0.0952380952380952 0.825647840531561 0.715150924484853 0.982236275323678 GO:0072542 protein phosphatase activator activity 2/2150 21/18639 0.0952380952380952 0.825647840531561 0.715150924484853 0.982236275323678 GO:0019894 kinesin binding 4/2150 42/18639 0.0952380952380952 0.825647840531561 0.72961969543985 0.990402078175837 GO:0004222 metalloendopeptidase activity 11/2150 110/18639 0.1 0.86693023255814 0.736562629280302 0.990402078175837 GO:0034062 5'-3' RNA polymerase activity 2/2150 22/18639 0.0909090909090909 0.788118393234672 0.739242284212672 0.990402078175837 GO:0097747 RNA polymerase activity 2/2150 22/18639 0.0909090909090909 0.788118393234672 0.739242284212672 0.990402078175837 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0001851 complement component C3b binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0002162 dystroglycan binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0004954 prostanoid receptor activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0008503 benzodiazepine receptor activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0010854 adenylate cyclase regulator activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0019206 nucleoside kinase activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0031731 CCR6 chemokine receptor binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0032404 mismatch repair complex binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0045294 alpha-catenin binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0050998 nitric-oxide synthase binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0070697 activin receptor binding 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0140537 transcription regulator activator activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0180030 inositol phosphate kinase activity 1/2150 11/18639 0.0909090909090909 0.788118393234672 0.740389865259697 0.990402078175837 GO:0004252 serine-type endopeptidase activity 18/2150 176/18639 0.102272727272727 0.886633192389006 0.741247012675324 0.990473231687635 GO:0015291 secondary active transmembrane transporter activity 30/2150 287/18639 0.104529616724739 0.906198849363909 0.744896381356748 0.994271226252995 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/2150 43/18639 0.0930232558139535 0.80644672796106 0.746696772170064 0.994838007553557 GO:0001664 G protein-coupled receptor binding 31/2150 297/18639 0.104377104377104 0.904876673713883 0.750537600418791 0.994838007553557 GO:0005539 glycosaminoglycan binding 25/2150 242/18639 0.103305785123967 0.895589083221219 0.751196585912291 0.994838007553557 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2150 23/18639 0.0869565217391304 0.753852376137513 0.761568865585723 0.994838007553557 GO:0003887 DNA-directed DNA polymerase activity 2/2150 23/18639 0.0869565217391304 0.753852376137513 0.761568865585723 0.994838007553557 GO:0008171 O-methyltransferase activity 2/2150 23/18639 0.0869565217391304 0.753852376137513 0.761568865585723 0.994838007553557 GO:0016493 C-C chemokine receptor activity 2/2150 23/18639 0.0869565217391304 0.753852376137513 0.761568865585723 0.994838007553557 GO:0016849 phosphorus-oxygen lyase activity 2/2150 23/18639 0.0869565217391304 0.753852376137513 0.761568865585723 0.994838007553557 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/2150 34/18639 0.0882352941176471 0.764938440492476 0.768256886095387 0.994838007553557 GO:0090482 vitamin transmembrane transporter activity 3/2150 34/18639 0.0882352941176471 0.764938440492476 0.768256886095387 0.994838007553557 GO:0000340 RNA 7-methylguanosine cap binding 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0004000 adenosine deaminase activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0004032 aldose reductase (NADPH) activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0005049 nuclear export signal receptor activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0005078 MAP-kinase scaffold activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0005247 voltage-gated chloride channel activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0008504 monoamine transmembrane transporter activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0015166 polyol transmembrane transporter activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0015368 calcium:monoatomic cation antiporter activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0016273 arginine N-methyltransferase activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0016274 protein-arginine N-methyltransferase activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0031543 peptidyl-proline dioxygenase activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0034452 dynactin binding 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0035497 cAMP response element binding 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0042301 phosphate ion binding 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0043047 single-stranded telomeric DNA binding 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0070410 co-SMAD binding 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0070679 inositol 1,4,5 trisphosphate binding 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0097371 MDM2/MDM4 family protein binding 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0140900 chloride:bicarbonate antiporter activity 1/2150 12/18639 0.0833333333333333 0.722441860465116 0.770353457147803 0.994838007553557 GO:0008276 protein methyltransferase activity 9/2150 95/18639 0.0947368421052632 0.821302325581395 0.781195415383303 1 GO:0005315 phosphate transmembrane transporter activity 2/2150 24/18639 0.0833333333333333 0.722441860465116 0.782217050107303 1 GO:0005540 hyaluronic acid binding 2/2150 24/18639 0.0833333333333333 0.722441860465116 0.782217050107303 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/2150 24/18639 0.0833333333333333 0.722441860465116 0.782217050107303 1 GO:0005343 organic acid:sodium symporter activity 3/2150 35/18639 0.0857142857142857 0.743083056478405 0.785313740916922 1 GO:0017124 SH3 domain binding 11/2150 115/18639 0.0956521739130435 0.829237613751264 0.787296121311397 1 GO:0035401 histone H3Y41 kinase activity 11/2150 115/18639 0.0956521739130435 0.829237613751264 0.787296121311397 1 GO:0140801 histone H2AXY142 kinase activity 11/2150 115/18639 0.0956521739130435 0.829237613751264 0.787296121311397 1 GO:0002161 aminoacyl-tRNA editing activity 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0004535 poly(A)-specific ribonuclease activity 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0009982 pseudouridine synthase activity 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0031994 insulin-like growth factor I binding 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0039706 co-receptor binding 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0045159 myosin II binding 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0046974 histone H3K9 methyltransferase activity 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0070700 BMP receptor binding 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0071714 icosanoid transmembrane transporter activity 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0140666 annealing activity 1/2150 13/18639 0.0769230769230769 0.666869409660107 0.796860144597861 1 GO:0050840 extracellular matrix binding 6/2150 67/18639 0.0895522388059701 0.776355432141618 0.79985914775666 1 GO:0001848 complement binding 2/2150 25/18639 0.08 0.693544186046512 0.801276779190685 1 GO:0005251 delayed rectifier potassium channel activity 2/2150 25/18639 0.08 0.693544186046512 0.801276779190685 1 GO:0019838 growth factor binding 13/2150 136/18639 0.0955882352941176 0.828683310533516 0.802422085284567 1 GO:0019888 protein phosphatase regulator activity 10/2150 107/18639 0.0934579439252336 0.810215170615084 0.803284060996377 1 GO:0140938 histone H3 methyltransferase activity 4/2150 47/18639 0.0851063829787234 0.737812963879268 0.806790006907025 1 GO:0019783 ubiquitin-like protein peptidase activity 12/2150 127/18639 0.094488188976378 0.819146676432888 0.807953917222464 1 GO:0004435 phosphatidylinositol phospholipase C activity 2/2150 26/18639 0.0769230769230769 0.666869409660107 0.818839584689177 1 GO:0005112 Notch binding 2/2150 26/18639 0.0769230769230769 0.666869409660107 0.818839584689177 1 GO:0015216 purine nucleotide transmembrane transporter activity 2/2150 26/18639 0.0769230769230769 0.666869409660107 0.818839584689177 1 GO:0051139 metal cation:proton antiporter activity 2/2150 26/18639 0.0769230769230769 0.666869409660107 0.818839584689177 1 GO:0004705 JUN kinase activity 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0008195 phosphatidate phosphatase activity 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0008559 ABC-type xenobiotic transporter activity 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0015926 glucosidase activity 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0032454 histone H3K9 demethylase activity 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0034236 protein kinase A catalytic subunit binding 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0043176 amine binding 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0046030 inositol trisphosphate phosphatase activity 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0061783 peptidoglycan muralytic activity 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0070742 C2H2 zinc finger domain binding 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0098847 sequence-specific single stranded DNA binding 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:1901612 cardiolipin binding 1/2150 14/18639 0.0714285714285714 0.619235880398671 0.820308587050057 1 GO:0000146 microfilament motor activity 3/2150 38/18639 0.0789473684210526 0.684418604651163 0.830321560943321 1 GO:0042162 telomeric DNA binding 3/2150 38/18639 0.0789473684210526 0.684418604651163 0.830321560943321 1 GO:0005385 zinc ion transmembrane transporter activity 2/2150 27/18639 0.0740740740740741 0.642170542635659 0.834997026059938 1 GO:0008395 steroid hydroxylase activity 2/2150 27/18639 0.0740740740740741 0.642170542635659 0.834997026059938 1 GO:0015252 proton channel activity 2/2150 27/18639 0.0740740740740741 0.642170542635659 0.834997026059938 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/2150 27/18639 0.0740740740740741 0.642170542635659 0.834997026059938 1 GO:0001098 basal transcription machinery binding 5/2150 60/18639 0.0833333333333333 0.722441860465116 0.836718200868268 1 GO:0001099 basal RNA polymerase II transcription machinery binding 5/2150 60/18639 0.0833333333333333 0.722441860465116 0.836718200868268 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/2150 60/18639 0.0833333333333333 0.722441860465116 0.836718200868268 1 GO:0000774 adenyl-nucleotide exchange factor activity 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0004953 icosanoid receptor activity 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0015250 water channel activity 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0030553 cGMP binding 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0045504 dynein heavy chain binding 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0061578 K63-linked deubiquitinase activity 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0140161 monocarboxylate:sodium symporter activity 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0140776 protein-containing complex destabilizing activity 1/2150 15/18639 0.0666666666666667 0.577953488372093 0.841051488410721 1 GO:0005242 inward rectifier potassium channel activity 2/2150 28/18639 0.0714285714285714 0.619235880398671 0.849839466622812 1 GO:0008527 taste receptor activity 2/2150 28/18639 0.0714285714285714 0.619235880398671 0.849839466622812 1 GO:0045499 chemorepellent activity 2/2150 28/18639 0.0714285714285714 0.619235880398671 0.849839466622812 1 GO:0097718 disordered domain specific binding 2/2150 28/18639 0.0714285714285714 0.619235880398671 0.849839466622812 1 GO:0003774 cytoskeletal motor activity 14/2150 153/18639 0.0915032679738562 0.793269493844049 0.855391114245545 1 GO:0004532 RNA exonuclease activity 3/2150 40/18639 0.075 0.650197674418605 0.855611281790865 1 GO:0032451 demethylase activity 3/2150 40/18639 0.075 0.650197674418605 0.855611281790865 1 GO:0071855 neuropeptide receptor binding 3/2150 40/18639 0.075 0.650197674418605 0.855611281790865 1 GO:0008296 3'-5'-DNA exonuclease activity 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0015378 sodium:chloride symporter activity 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0015562 efflux transmembrane transporter activity 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0030275 LRR domain binding 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0043023 ribosomal large subunit binding 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0070411 I-SMAD binding 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0097027 ubiquitin-protein transferase activator activity 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0140327 flippase activity 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0140328 floppase activity 1/2150 16/18639 0.0625 0.541831395348837 0.859400892401107 1 GO:0042562 hormone binding 8/2150 94/18639 0.0851063829787234 0.737812963879268 0.862790554739457 1 GO:0003785 actin monomer binding 2/2150 29/18639 0.0689655172413793 0.597882919005613 0.863455131535488 1 GO:0004629 phospholipase C activity 2/2150 29/18639 0.0689655172413793 0.597882919005613 0.863455131535488 1 GO:0106222 lncRNA binding 2/2150 29/18639 0.0689655172413793 0.597882919005613 0.863455131535488 1 GO:0004527 exonuclease activity 7/2150 84/18639 0.0833333333333333 0.722441860465116 0.86535603372996 1 GO:0042169 SH2 domain binding 3/2150 41/18639 0.0731707317073171 0.634339194554736 0.866973183608505 1 GO:0101005 deubiquitinase activity 10/2150 115/18639 0.0869565217391304 0.753852376137513 0.867355282192957 1 GO:0005125 cytokine activity 22/2150 234/18639 0.094017094017094 0.815062611806798 0.872863501192414 1 GO:0015294 solute:monoatomic cation symporter activity 10/2150 116/18639 0.0862068965517241 0.747353648757017 0.87403549558203 1 GO:0016018 cyclosporin A binding 1/2150 17/18639 0.0588235294117647 0.509958960328317 0.875632867987083 1 GO:0017110 nucleoside diphosphate phosphatase activity 1/2150 17/18639 0.0588235294117647 0.509958960328317 0.875632867987083 1 GO:0030548 acetylcholine receptor regulator activity 1/2150 17/18639 0.0588235294117647 0.509958960328317 0.875632867987083 1 GO:0045236 CXCR chemokine receptor binding 1/2150 17/18639 0.0588235294117647 0.509958960328317 0.875632867987083 1 GO:1990226 histone methyltransferase binding 1/2150 17/18639 0.0588235294117647 0.509958960328317 0.875632867987083 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/2150 30/18639 0.0666666666666667 0.577953488372093 0.875929398822626 1 GO:0016769 transferase activity, transferring nitrogenous groups 2/2150 30/18639 0.0666666666666667 0.577953488372093 0.875929398822626 1 GO:0033612 receptor serine/threonine kinase binding 2/2150 30/18639 0.0666666666666667 0.577953488372093 0.875929398822626 1 GO:0043175 RNA polymerase core enzyme binding 3/2150 42/18639 0.0714285714285714 0.619235880398671 0.877538836544556 1 GO:0001216 DNA-binding transcription activator activity 49/2150 491/18639 0.09979633401222 0.865164590536636 0.879425992190865 1 GO:0017069 snRNA binding 4/2150 54/18639 0.0740740740740741 0.642170542635659 0.883681595228497 1 GO:0140597 protein carrier chaperone 17/2150 188/18639 0.0904255319148936 0.783926274121722 0.885888831334692 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 48/2150 484/18639 0.0991735537190083 0.85976551989237 0.886811945788188 1 GO:0005184 neuropeptide hormone activity 2/2150 31/18639 0.0645161290322581 0.559309827456864 0.887344282266875 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/2150 31/18639 0.0645161290322581 0.559309827456864 0.887344282266875 1 GO:0005452 solute:inorganic anion antiporter activity 2/2150 31/18639 0.0645161290322581 0.559309827456864 0.887344282266875 1 GO:0042393 histone binding 23/2150 247/18639 0.0931174089068826 0.807262969588551 0.887777817798262 1 GO:0004843 cysteine-type deubiquitinase activity 9/2150 108/18639 0.0833333333333333 0.722441860465116 0.888314307045255 1 GO:0000400 four-way junction DNA binding 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0003746 translation elongation factor activity 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0005372 water transmembrane transporter activity 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0008308 voltage-gated monoatomic anion channel activity 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0015373 monoatomic anion:sodium symporter activity 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0031690 adrenergic receptor binding 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0070628 proteasome binding 1/2150 18/18639 0.0555555555555556 0.481627906976744 0.889991655111332 1 GO:0140097 catalytic activity, acting on DNA 32/2150 336/18639 0.0952380952380952 0.825647840531561 0.897021180340365 1 GO:0030515 snoRNA binding 2/2150 32/18639 0.0625 0.541831395348837 0.897778071365225 1 GO:0140142 nucleocytoplasmic carrier activity 2/2150 32/18639 0.0625 0.541831395348837 0.897778071365225 1 GO:0160041 neuropeptide activity 2/2150 32/18639 0.0625 0.541831395348837 0.897778071365225 1 GO:0042054 histone methyltransferase activity 5/2150 67/18639 0.0746268656716418 0.646962860118015 0.898597434347985 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 16/2150 181/18639 0.0883977900552486 0.766347166902223 0.899485500271083 1 GO:0005229 intracellularly calcium-gated chloride channel activity 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:0030506 ankyrin binding 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:0042577 lipid phosphatase activity 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:0042834 peptidoglycan binding 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:0046624 sphingolipid transporter activity 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:0140036 ubiquitin-modified protein reader activity 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:0141147 intracellularly calcium-gated channel activity 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:1990380 K48-linked deubiquitinase activity 1/2150 19/18639 0.0526315789473684 0.456279069767442 0.9026933328682 1 GO:0051082 unfolded protein binding 10/2150 121/18639 0.0826446280991736 0.716471266576975 0.903453766603305 1 GO:0046982 protein heterodimerization activity 35/2150 369/18639 0.0948509485094851 0.82229154849688 0.910701341912698 1 GO:0043022 ribosome binding 9/2150 112/18639 0.0803571428571429 0.696640365448505 0.910877781294277 1 GO:0010851 cyclase regulator activity 1/2150 20/18639 0.05 0.43346511627907 0.91392906510952 1 GO:0043024 ribosomal small subunit binding 1/2150 20/18639 0.05 0.43346511627907 0.91392906510952 1 GO:0061608 nuclear import signal receptor activity 1/2150 20/18639 0.05 0.43346511627907 0.91392906510952 1 GO:0070888 E-box binding 4/2150 59/18639 0.0677966101694915 0.587749310208908 0.920833864887766 1 GO:0015293 symporter activity 12/2150 146/18639 0.0821917808219178 0.712545396623128 0.923261678280559 1 GO:0001846 opsonin binding 1/2150 21/18639 0.0476190476190476 0.412823920265781 0.923867972140753 1 GO:0015125 bile acid transmembrane transporter activity 1/2150 21/18639 0.0476190476190476 0.412823920265781 0.923867972140753 1 GO:0061891 calcium ion sensor activity 1/2150 21/18639 0.0476190476190476 0.412823920265781 0.923867972140753 1 GO:1904047 S-adenosyl-L-methionine binding 1/2150 21/18639 0.0476190476190476 0.412823920265781 0.923867972140753 1 GO:0140299 molecular sensor activity 5/2150 71/18639 0.0704225352112676 0.61051424828038 0.923896026674026 1 GO:0034061 DNA polymerase activity 2/2150 35/18639 0.0571428571428571 0.495388704318937 0.923915725750315 1 GO:0099094 ligand-gated monoatomic cation channel activity 11/2150 136/18639 0.0808823529411765 0.701193570451436 0.924859978412912 1 GO:0140658 ATP-dependent chromatin remodeler activity 13/2150 158/18639 0.0822784810126582 0.713297026788343 0.929617521234799 1 GO:0140104 molecular carrier activity 22/2150 249/18639 0.0883534136546185 0.765962454469039 0.92979400583808 1 GO:0000993 RNA polymerase II complex binding 2/2150 36/18639 0.0555555555555556 0.481627906976744 0.931127439431175 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/2150 36/18639 0.0555555555555556 0.481627906976744 0.931127439431175 1 GO:0008013 beta-catenin binding 8/2150 106/18639 0.0754716981132075 0.654286967968407 0.932642171026799 1 GO:0008649 rRNA methyltransferase activity 1/2150 22/18639 0.0454545454545455 0.394059196617336 0.932659671565899 1 GO:0015377 chloride:monoatomic cation symporter activity 1/2150 22/18639 0.0454545454545455 0.394059196617336 0.932659671565899 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/2150 22/18639 0.0454545454545455 0.394059196617336 0.932659671565899 1 GO:0140517 protein-RNA adaptor activity 1/2150 22/18639 0.0454545454545455 0.394059196617336 0.932659671565899 1 GO:0140784 metal ion sensor activity 1/2150 22/18639 0.0454545454545455 0.394059196617336 0.932659671565899 1 GO:0043539 protein serine/threonine kinase activator activity 5/2150 73/18639 0.0684931506849315 0.593787830519274 0.934309660228135 1 GO:0031491 nucleosome binding 5/2150 74/18639 0.0675675675675676 0.585763670647392 0.939022119979736 1 GO:0005212 structural constituent of eye lens 1/2150 23/18639 0.0434782608695652 0.376926188068756 0.94043652638318 1 GO:0017134 fibroblast growth factor binding 1/2150 23/18639 0.0434782608695652 0.376926188068756 0.94043652638318 1 GO:0031681 G-protein beta-subunit binding 1/2150 23/18639 0.0434782608695652 0.376926188068756 0.94043652638318 1 GO:0140102 catalytic activity, acting on a rRNA 1/2150 23/18639 0.0434782608695652 0.376926188068756 0.94043652638318 1 GO:0044183 protein folding chaperone 5/2150 75/18639 0.0666666666666667 0.577953488372093 0.94342827256715 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/2150 38/18639 0.0526315789473684 0.456279069767442 0.943653549792956 1 GO:0140674 ATP-dependent histone chaperone activity 12/2150 152/18639 0.0789473684210526 0.684418604651163 0.944427417051556 1 GO:0008170 N-methyltransferase activity 7/2150 98/18639 0.0714285714285714 0.619235880398671 0.944503889413097 1 GO:0015149 hexose transmembrane transporter activity 1/2150 24/18639 0.0416666666666667 0.361220930232558 0.947315634047349 1 GO:0048027 mRNA 5'-UTR binding 1/2150 24/18639 0.0416666666666667 0.361220930232558 0.947315634047349 1 GO:0055056 D-glucose transmembrane transporter activity 1/2150 24/18639 0.0416666666666667 0.361220930232558 0.947315634047349 1 GO:0070840 dynein complex binding 1/2150 24/18639 0.0416666666666667 0.361220930232558 0.947315634047349 1 GO:0140034 methylation-dependent protein binding 5/2150 76/18639 0.0657894736842105 0.570348837209302 0.947544862339538 1 GO:0005179 hormone activity 10/2150 132/18639 0.0757575757575758 0.65676532769556 0.948420674263999 1 GO:0140713 histone chaperone activity 13/2150 164/18639 0.0792682926829268 0.687200794100964 0.94871767796726 1 GO:0003724 RNA helicase activity 5/2150 77/18639 0.0649350649350649 0.562941709453337 0.951388042760501 1 GO:0004864 protein phosphatase inhibitor activity 3/2150 53/18639 0.0566037735849057 0.490715225976305 0.952905406859766 1 GO:0008483 transaminase activity 1/2150 25/18639 0.04 0.346772093023256 0.953400586333043 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/2150 25/18639 0.04 0.346772093023256 0.953400586333043 1 GO:0017056 structural constituent of nuclear pore 1/2150 25/18639 0.04 0.346772093023256 0.953400586333043 1 GO:0019199 transmembrane receptor protein kinase activity 5/2150 78/18639 0.0641025641025641 0.555724508050089 0.954973360650168 1 GO:0005267 potassium channel activity 9/2150 124/18639 0.0725806451612903 0.629223555888972 0.956778083680001 1 GO:0005261 monoatomic cation channel activity 30/2150 341/18639 0.0879765395894428 0.76269521925936 0.957960614254088 1 GO:0008186 ATP-dependent activity, acting on RNA 5/2150 79/18639 0.0632911392405063 0.548690020606417 0.958315746036257 1 GO:0140828 metal cation:monoatomic cation antiporter activity 2/2150 41/18639 0.0487804878048781 0.422892796369824 0.958453636729858 1 GO:0015145 monosaccharide transmembrane transporter activity 1/2150 26/18639 0.0384615384615385 0.333434704830054 0.958783026398798 1 GO:0008094 ATP-dependent activity, acting on DNA 17/2150 210/18639 0.080952380952381 0.701800664451827 0.958888033357469 1 GO:0098632 cell-cell adhesion mediator activity 3/2150 55/18639 0.0545454545454545 0.472871035940803 0.960717497503512 1 GO:0031492 nucleosomal DNA binding 2/2150 42/18639 0.0476190476190476 0.412823920265781 0.962499376739123 1 GO:0035198 miRNA binding 2/2150 42/18639 0.0476190476190476 0.412823920265781 0.962499376739123 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/2150 27/18639 0.037037037037037 0.321085271317829 0.963544026411831 1 GO:0019212 phosphatase inhibitor activity 3/2150 56/18639 0.0535714285714286 0.464426910299003 0.96415033774577 1 GO:0003689 DNA clamp loader activity 12/2150 160/18639 0.075 0.650197674418605 0.964649368417771 1 GO:0016279 protein-lysine N-methyltransferase activity 4/2150 69/18639 0.0579710144927536 0.502568250758342 0.964966475033498 1 GO:0005245 voltage-gated calcium channel activity 2/2150 43/18639 0.0465116279069767 0.40322336398053 0.966165102854561 1 GO:0016866 intramolecular transferase activity 1/2150 28/18639 0.0357142857142857 0.309617940199336 0.967755306404017 1 GO:0051119 sugar transmembrane transporter activity 1/2150 28/18639 0.0357142857142857 0.309617940199336 0.967755306404017 1 GO:0016278 lysine N-methyltransferase activity 4/2150 70/18639 0.0571428571428571 0.495388704318937 0.967803313283147 1 GO:0004497 monooxygenase activity 7/2150 106/18639 0.0660377358490566 0.572501096972356 0.968042668168686 1 GO:0000510 H3-H4 histone complex chaperone activity 11/2150 151/18639 0.0728476821192053 0.631538580009241 0.968354072328039 1 GO:0140584 chromatin extrusion motor activity 11/2150 151/18639 0.0728476821192053 0.631538580009241 0.968354072328039 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 11/2150 151/18639 0.0728476821192053 0.631538580009241 0.968354072328039 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 11/2150 151/18639 0.0728476821192053 0.631538580009241 0.968354072328039 1 GO:0008408 3'-5' exonuclease activity 3/2150 58/18639 0.0517241379310345 0.44841218925421 0.970185156401578 1 GO:0015616 DNA translocase activity 11/2150 152/18639 0.0723684210526316 0.627383720930233 0.970220690824786 1 GO:0061775 cohesin loader activity 11/2150 153/18639 0.0718954248366013 0.62328317373461 0.971987578723969 1 GO:0140303 intramembrane lipid transporter activity 2/2150 45/18639 0.0444444444444444 0.385302325581395 0.972488932211882 1 GO:0036002 pre-mRNA binding 3/2150 59/18639 0.0508474576271186 0.440811982656681 0.972828975589818 1 GO:0022843 voltage-gated monoatomic cation channel activity 10/2150 143/18639 0.0699300699300699 0.606244917872825 0.973831764700153 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/2150 46/18639 0.0434782608695652 0.376926188068756 0.975206589981111 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/2150 60/18639 0.05 0.43346511627907 0.975249336062785 1 GO:0005249 voltage-gated potassium channel activity 6/2150 98/18639 0.0612244897959184 0.530773611770289 0.97575126803084 1 GO:0035064 methylated histone binding 4/2150 74/18639 0.0540540540540541 0.468610936517913 0.977139651566572 1 GO:0017147 Wnt-protein binding 1/2150 31/18639 0.032258064516129 0.279654913728432 0.977689534729458 1 GO:0015106 bicarbonate transmembrane transporter activity 1/2150 32/18639 0.03125 0.270915697674419 0.980267323870239 1 GO:0098631 cell adhesion mediator activity 4/2150 76/18639 0.0526315789473684 0.456279069767442 0.980788552066632 1 GO:0042923 neuropeptide binding 1/2150 33/18639 0.0303030303030303 0.262706131078224 0.982547393396707 1 GO:0005244 voltage-gated monoatomic ion channel activity 12/2150 173/18639 0.069364161849711 0.601338889635704 0.983866917594053 1 GO:0140101 catalytic activity, acting on a tRNA 9/2150 139/18639 0.0647482014388489 0.561321733311026 0.983953412641951 1 GO:0019825 oxygen binding 1/2150 34/18639 0.0294117647058824 0.254979480164159 0.984564114035054 1 GO:0015370 solute:sodium symporter activity 4/2150 79/18639 0.0506329113924051 0.438952016485134 0.985245570409657 1 GO:0005272 sodium channel activity 2/2150 51/18639 0.0392156862745098 0.339972640218878 0.985335140109994 1 GO:0016597 amino acid binding 2/2150 51/18639 0.0392156862745098 0.339972640218878 0.985335140109994 1 GO:0022832 voltage-gated channel activity 12/2150 175/18639 0.0685714285714286 0.594466445182724 0.985772823468908 1 GO:0000175 3'-5'-RNA exonuclease activity 1/2150 35/18639 0.0285714285714286 0.247694352159468 0.986347890161076 1 GO:0140566 histone reader activity 1/2150 35/18639 0.0285714285714286 0.247694352159468 0.986347890161076 1 GO:0000049 tRNA binding 4/2150 80/18639 0.05 0.43346511627907 0.986499047432301 1 GO:0045505 dynein intermediate chain binding 1/2150 36/18639 0.0277777777777778 0.240813953488372 0.987925617324787 1 GO:0055106 ubiquitin-protein transferase regulator activity 1/2150 36/18639 0.0277777777777778 0.240813953488372 0.987925617324787 1 GO:0004386 helicase activity 10/2150 155/18639 0.0645161290322581 0.559309827456864 0.988147776633642 1 GO:0022829 wide pore channel activity 1/2150 37/18639 0.027027027027027 0.234305468258957 0.989321087020627 1 GO:0140463 chromatin-protein adaptor activity 2/2150 54/18639 0.037037037037037 0.321085271317829 0.989337633463322 1 GO:0005254 chloride channel activity 4/2150 83/18639 0.0481927710843374 0.417797702437658 0.989679411678306 1 GO:0005109 frizzled binding 1/2150 38/18639 0.0263157894736842 0.228139534883721 0.990555344783537 1 GO:0015079 potassium ion transmembrane transporter activity 10/2150 160/18639 0.0625 0.541831395348837 0.99160083347702 1 GO:0140662 ATP-dependent protein folding chaperone 1/2150 40/18639 0.025 0.216732558139535 0.99261254112887 1 GO:0015276 ligand-gated monoatomic ion channel activity 12/2150 186/18639 0.0645161290322581 0.559309827456864 0.993030182564488 1 GO:0017116 single-stranded DNA helicase activity 2/2150 58/18639 0.0344827586206897 0.298941459502807 0.993055177042493 1 GO:0004812 aminoacyl-tRNA ligase activity 1/2150 41/18639 0.024390243902439 0.211446398184912 0.993466513738845 1 GO:0008227 G protein-coupled amine receptor activity 1/2150 41/18639 0.024390243902439 0.211446398184912 0.993466513738845 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/2150 41/18639 0.024390243902439 0.211446398184912 0.993466513738845 1 GO:0022834 ligand-gated channel activity 12/2150 188/18639 0.0638297872340425 0.553359722909451 0.993901702678395 1 GO:0005253 monoatomic anion channel activity 5/2150 103/18639 0.0485436893203883 0.420839918717543 0.994258084436122 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 10/2150 167/18639 0.0598802395209581 0.519119899735413 0.994880973985786 1 GO:0008168 methyltransferase activity 13/2150 204/18639 0.0637254901960784 0.552455540355677 0.995459709862741 1 GO:0015108 chloride transmembrane transporter activity 6/2150 121/18639 0.0495867768595041 0.429882759946185 0.996194978344001 1 GO:0016887 ATP hydrolysis activity 32/2150 417/18639 0.0767386091127098 0.665270202442697 0.996559701460605 1 GO:0046873 metal ion transmembrane transporter activity 35/2150 450/18639 0.0777777777777778 0.674279069767442 0.996796555746359 1 GO:0140098 catalytic activity, acting on RNA 29/2150 387/18639 0.0749354005167959 0.649637641968632 0.996866687326182 1 GO:0061749 forked DNA-dependent helicase activity 1/2150 47/18639 0.0212765957446809 0.184453240969817 0.996874062359567 1 GO:0099095 ligand-gated monoatomic anion channel activity 1/2150 47/18639 0.0212765957446809 0.184453240969817 0.996874062359567 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/2150 47/18639 0.0212765957446809 0.184453240969817 0.996874062359567 1 GO:0009378 four-way junction helicase activity 1/2150 48/18639 0.0208333333333333 0.180610465116279 0.997235549339285 1 GO:0036121 double-stranded DNA helicase activity 1/2150 48/18639 0.0208333333333333 0.180610465116279 0.997235549339285 1 GO:0043138 3'-5' DNA helicase activity 1/2150 48/18639 0.0208333333333333 0.180610465116279 0.997235549339285 1 GO:0003777 microtubule motor activity 2/2150 68/18639 0.0294117647058824 0.254979480164159 0.997659596139133 1 GO:0016741 transferase activity, transferring one-carbon groups 13/2150 215/18639 0.0604651162790698 0.524190373174689 0.997850424296351 1 GO:0005216 monoatomic ion channel activity 34/2150 448/18639 0.0758928571428571 0.657938122923588 0.997899374976978 1 GO:0005010 insulin-like growth factor receptor activity 1/2150 51/18639 0.0196078431372549 0.169986320109439 0.998088051838528 1 GO:0005021 vascular endothelial growth factor receptor activity 1/2150 51/18639 0.0196078431372549 0.169986320109439 0.998088051838528 1 GO:0005201 extracellular matrix structural constituent 9/2150 168/18639 0.0535714285714286 0.464426910299003 0.998099404806607 1 GO:0005003 ephrin receptor activity 1/2150 53/18639 0.0188679245283019 0.163571741992102 0.998504777988994 1 GO:0005005 transmembrane-ephrin receptor activity 1/2150 53/18639 0.0188679245283019 0.163571741992102 0.998504777988994 1 GO:0017046 peptide hormone binding 1/2150 53/18639 0.0188679245283019 0.163571741992102 0.998504777988994 1 GO:0038064 collagen receptor activity 1/2150 53/18639 0.0188679245283019 0.163571741992102 0.998504777988994 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/2150 73/18639 0.0273972602739726 0.237515132207709 0.998651033629 1 GO:0003678 DNA helicase activity 2/2150 74/18639 0.027027027027027 0.234305468258957 0.998792389574034 1 GO:0008509 monoatomic anion transmembrane transporter activity 7/2150 149/18639 0.0469798657718121 0.407282659591072 0.998911006795231 1 GO:0008528 G protein-coupled peptide receptor activity 5/2150 122/18639 0.040983606557377 0.355299275638582 0.998958868087694 1 GO:0015103 inorganic anion transmembrane transporter activity 8/2150 165/18639 0.0484848484848485 0.420329809725159 0.999136745695855 1 GO:0001653 peptide receptor activity 5/2150 128/18639 0.0390625 0.338644622093023 0.999404416516797 1 GO:0022836 gated channel activity 20/2150 318/18639 0.0628930817610063 0.545239139973673 0.999476218974768 1 GO:0019843 rRNA binding 1/2150 65/18639 0.0153846153846154 0.133373881932021 0.999658157344382 1 GO:0015081 sodium ion transmembrane transporter activity 7/2150 164/18639 0.0426829268292683 0.370031196823596 0.999703473947811 1 GO:0008173 RNA methyltransferase activity 1/2150 67/18639 0.0149253731343284 0.129392572023603 0.999732717710371 1 GO:0016500 protein-hormone receptor activity 1/2150 67/18639 0.0149253731343284 0.129392572023603 0.999732717710371 1 GO:0030594 neurotransmitter receptor activity 2/2150 97/18639 0.0206185567010309 0.178748501558379 0.999908783765033 1 GO:0003735 structural constituent of ribosome 6/2150 175/18639 0.0342857142857143 0.297233222591362 0.999971860957442 1 GO:0003730 mRNA 3'-UTR binding 11/2150 262/18639 0.0419847328244275 0.363978341913723 0.99999282449397 1 GO:0045182 translation regulator activity 9/2150 356/18639 0.0252808988764045 0.219167755422002 0.999999999949998 1 GO:0030371 translation repressor activity 4/2150 329/18639 0.0121580547112462 0.105401851982753 0.999999999999969 1 GO:1903231 mRNA base-pairing translational repressor activity 1/2150 298/18639 0.00335570469798658 0.0290916185422194 1 1