category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	17/288	110/9376	5.03131313131313	LEFTY2/DCN/FST/LTBP1/INHBA/INHBB/NBL1/GREM1/THBS1/SMAD3/GDF6/BMP5/E2F4/LEMD3/NCOR1/CHRD/SMURF1	7.57084667149269
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/288	82/9376	5.16124661246613	HLA-DRA/CD74/HLA-DQA2/HLA-DRB1/HLA-B/HLA-E/CTSB/CTSS/HLA-DPA1/B2M/HSPA6/HLA-DMA/HLA-DPB1	6.73715857520497
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/288	155/9376	3.78064516129032	HLA-DRA/HLA-DQA2/HLA-DRB1/CD36/C3/HLA-B/HLA-E/CTSS/HLA-DPA1/ACTG1/THBS1/SCARB1/DYNC2H1/HLA-DMA/HLA-DPB1/SEC61A2/ATP6V0A1/OLR1	6.21398403259143
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/288	70/9376	5.58095238095238	HLA-DRA/HLA-DQA2/DTNA/HLA-DRB1/HLA-B/HLA-E/HLA-DPA1/ACTG1/DMD/CD55/HLA-DMA/HLA-DPB1	6.84811423201611
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/288	233/9376	3.07391511683357	ITGA11/DCN/DTNA/MYH11/TNNI3/COL4A4/FMNL2/DES/SDC2/VCL/LMOD1/ACTG1/THBS1/TPM4/ZYX/TMOD1/CSRP1/MYL9/DMD/FHL1/SYNPO2/BGN	5.70653257502993
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/288	181/9376	3.41743400859423	HLA-DRA/CD74/SPHK1/HLA-DQA2/HLA-DRB1/C3/CTSD/CTSS/BCL2/VDR/HLA-DPA1/FCER1G/IFNGR2/AKT3/HLA-DMA/IFNGR1/HLA-DPB1/APAF1/ATP6V0A1	5.84609368891326
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	18/288	168/9376	3.48809523809524	CLCF1/BCL2/PIM1/CSH2/IL11/IL20/CSH1/PRLR/IFNGR2/SOCS4/AKT3/IL13RA1/IL6ST/FHL1/IFNGR1/CISH/IFNAR1/STAM2	5.79277564443565
Human Diseases	Immune disease	hsa05310	Asthma	8/288	32/9376	8.13888888888889	HLA-DRA/PRG2/HLA-DQA2/HLA-DRB1/HLA-DPA1/FCER1G/HLA-DMA/HLA-DPB1	7.20090231942193
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	18/288	180/9376	3.25555555555556	HLA-DRA/CD74/HLA-DQA2/HLA-DRB1/C3/HLA-B/HLA-E/BCL2/HLA-DPA1/TNFSF14/IFNGR2/AKT3/B2M/HLA-DMA/IFNGR1/HLA-DPB1/IFNAR1/APAF1	5.43923750336864
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/288	203/9376	3.04707170224412	SPP1/MYLK/ITGA11/COL4A4/ROCK2/PDGFC/VCL/BCL2/TNC/VEGFA/RAP1B/ACTG1/THBS1/PDGFD/AKT3/ZYX/ACTN4/MYL9/CAPN2	5.24895802671404
Human Diseases	Immune disease	hsa05330	Allograft rejection	8/288	39/9376	6.67806267806268	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-B/HLA-E/HLA-DPA1/HLA-DMA/HLA-DPB1	6.32523301705823
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/288	44/9376	5.91919191919192	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-B/HLA-E/HLA-DPA1/HLA-DMA/HLA-DPB1	5.822110753075
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/288	45/9376	5.78765432098765	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-B/HLA-E/HLA-DPA1/HLA-DMA/HLA-DPB1	5.73076593836931
NA	NA	hsa04518	Integrin signaling	15/288	154/9376	3.17099567099567	SPP1/ITGA11/COL4A4/C3/PDGFC/VCL/TNC/VEGFA/ACTG1/THBS1/FERMT2/PDGFD/AKT3/ACTN4/VCAM1	4.83564579511287
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/288	112/9376	3.48809523809524	HLA-DRA/HLA-DQA2/HLA-DRB1/BCL2/HLA-DPA1/IFNGR2/AKT3/LY96/HSPA6/HLA-DMA/IFNGR1/HLA-DPB1	4.71546429846063
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/288	66/9376	4.43939393939394	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-DPA1/IFNGR2/SMAD3/HLA-DMA/IFNGR1/HLA-DPB1	4.99145053720096
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/288	54/9376	4.82304526748971	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-B/HLA-E/HLA-DPA1/HLA-DMA/HLA-DPB1	5.01532976655982
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/288	232/9376	2.52586206896552	MYLK/ITGA11/MYH11/CFL2/ROCK2/PDGFC/VCL/FGF7/GSN/FGF2/FGF5/ACTG1/APC/PDGFD/AKT3/ACTN4/BDKRB2/MYL9	4.18927513252315
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/288	137/9376	3.08921330089213	MAP3K5/CTSD/GADD45G/CTSB/CTSS/BCL2/ACTG1/AKT3/PTPN13/ERN1/CAPN2/PARP4/APAF1	4.38508791715504
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/288	88/9376	3.69949494949495	C3/F3/CD59/CFH/PLAUR/SERPING1/SERPINA1/SERPINE2/BDKRB2/CD55	4.52908503618609
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	16/288	205/9376	2.54092140921409	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-B/GADD45G/HLA-E/BCL2/HLA-DPA1/AKT3/B2M/NCOR2/MAP2K4/HLA-DMA/HLA-DPB1/IFNAR1/APAF1	3.97097173580841
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/288	78/9376	3.75641025641026	HLA-DRA/HLA-DQA2/HLA-DRB1/C3/HLA-DPA1/IFNGR2/HLA-DMA/IFNGR1/HLA-DPB1	4.35155132805972
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/288	95/9376	3.42690058479532	HLA-DRA/HLA-DQA2/HLA-DRB1/VEGFA/HLA-DPA1/IL11/CXCL3/HLA-DMA/HLA-DPB1/ATP6V0A1	4.2321799513496
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	20/288	298/9376	2.18493661446682	CLCF1/INHBA/INHBB/CSH2/TNFSF14/TNFRSF12A/IL11/IL20/CSH1/PRLR/IFNGR2/GDF6/BMP5/CXCL3/IL13RA1/IL6ST/GDF9/CXCL11/IFNGR1/IFNAR1	3.70046145709146
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/288	100/9376	3.25555555555556	HLA-DRA/HLA-DQA2/HLA-DRB1/CD36/CD59/HLA-DPA1/IL11/CD55/HLA-DMA/HLA-DPB1	4.03664801177057
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/288	216/9376	2.41152263374486	CD36/MAP3K5/ROCK2/BCL2/RAP1B/MMP9/AKT3/CXCL3/LY96/NFE2L2/HSPA6/MAP2K4/ERN1/APAF1/VCAM1/OLR1	3.73606744838621
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/288	160/9376	2.64513888888889	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-B/NFASC/HLA-E/SDC2/HLA-DPA1/PTPRM/HLA-DMA/CLDN10/HLA-DPB1/VCAM1	3.73627685674207
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/288	204/9376	2.3937908496732	DCN/LUM/SDC2/ROCK2/TIMP3/VEGFA/MMP9/PLAUR/WNT2/FGF2/WNT10A/ACTG1/THBS1/AKT3/WNT4	3.58284807182663
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/288	144/9376	2.71296296296296	LEFTY2/INHBA/INHBB/WNT2/FGF2/WNT10A/APC/SMAD3/AKT3/TBX3/IL6ST/WNT4	3.68747465482669
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/288	125/9376	2.86488888888889	SPHK1/MAP3K5/CTSD/ROCK2/BCL2/FCER1G/AKT3/CERS6/S1PR3/BDKRB2/SPTLC2	3.73646871517056
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/288	109/9376	2.98674821610601	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-DPA1/IFNGR2/SMAD3/IL6ST/HLA-DMA/IFNGR1/HLA-DPB1	3.71393434575004
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/288	93/9376	3.1505376344086	ROCK2/VCL/RAP1B/ACTG1/SMAD3/ACTN4/PTPRM/MYL9/SMURF1	3.71015513191785
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/288	101/9376	2.9009900990099	COL4A4/F3/BCL2/PIM1/VEGFA/SMAD3/AKT3/NOX4/VCAM1	3.41925354267521
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/288	50/9376	3.90666666666667	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-DPA1/HLA-DMA/HLA-DPB1	3.6684301125037
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/288	150/9376	2.38740740740741	GADD45G/BCL2/FGF7/WNT2/FGF2/WNT10A/FGF5/APC/SMAD3/AKT3/WNT4	3.04923317509742
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/288	73/9376	3.12176560121766	GADD45G/PDGFC/FGF7/FGF2/FGF5/PDGFD/AKT3	3.2396272747604
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/288	173/9376	2.25818882466281	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-DPA1/ACTG1/IFNGR2/AKT3/HLA-DMA/IFNGR1/HLA-DPB1/IFNAR1/APAF1	2.97339007108974
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/288	93/9376	2.80047789725209	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-DPA1/IFNGR2/HLA-DMA/IFNGR1/HLA-DPB1	3.10622432433345
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	20/288	362/9376	1.79864947820749	SPP1/ITGA11/COL4A4/PDGFC/BCL2/FGF7/TNC/VEGFA/CSH2/IRS1/FGF2/FGF5/THBS1/CSH1/PDGFD/PRLR/MYB/AKT3/IFNAR1/RBL2	2.75866804045452
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/288	116/9376	2.52586206896552	ROCK2/VCL/RAP1B/MMP9/ACTG1/ACTN4/MYL9/CLDN10/VCAM1	2.9436522379925
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/288	99/9376	2.6307519640853	HLA-DRA/HLA-DQA2/HLA-DRB1/C3/CFH/HLA-DPA1/HLA-DMA/HLA-DPB1	2.90368467287722
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/288	80/9376	2.84861111111111	AXL/PDGFC/BCL2/VEGFA/FGF2/PDGFD/AKT3	2.95590326972532
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/288	142/9376	2.29264475743349	MAP3K5/SDC2/BCL2/VEGFA/MMP9/ACTG1/AKT3/NFE2L2/MAP2K4/VCAM1	2.76296987096485
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/288	144/9376	2.2608024691358	C3/MAP3K5/ADH1B/AKT3/CXCL3/NOX4/LY96/LPIN2/MAP2K4/TAB3	2.71411422792198
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/288	196/9376	1.99319727891156	C3/HLA-B/HLA-E/VEGFA/FGF2/CLEC2B/AKT3/CXCL3/IL6ST/MAP2K4/IFNGR1/IFNAR1	2.50143912873503
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/288	51/9376	3.1917211328976	LPCAT2/PLA2G7/UGT8/ENPP2/TMEM86A	2.79378953277074
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/288	224/9376	1.88938492063492	HLA-DRA/HLA-DQA2/HLA-DRB1/HLA-B/HLA-E/HLA-DPA1/ETS2/SMAD3/AKT3/B2M/MAP2K4/HLA-DMA/HLA-DPB1	2.39829989328629
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/288	52/9376	3.13034188034188	CYP1B1/SCARB1/HSD17B7/HSD3B2/HSD17B2	2.7421901564067
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/288	134/9376	2.1865671641791	MYLK/MYH11/CALD1/RAMP1/ROCK2/ACTA2/RAMP3/KCNMB1/MYL9	2.4626884068579
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/288	157/9376	2.07360226468507	IGFBP3/HLA-B/GADD45G/HLA-E/ZFP36L2/SMAD3/AKT3/E2F4/CAPN2/RBL2	2.4148994942378
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/288	119/9376	2.18860877684407	MAP3K5/MMP9/AKT3/CXCL3/RHBDF1/MAP2K4/TAB3/VCAM1	2.32287053201684
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/288	166/9376	1.9611780455154	MYLK/TRPC6/ROCK2/IRS1/AKT3/KCNMB1/BDKRB2/MYL9/IRS2/RGS2	2.22421002687904
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/288	99/9376	2.30190796857464	ITGA11/DTNA/TNNI3/DES/ACTG1/TPM4/DMD	2.3181515626549
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/288	122/9376	2.13479052823315	IGFBP3/CSH2/IRS1/MRAP2/CSH1/AKT3/MAP2K4/IRS2	2.24583886336984
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/288	169/9376	1.92636423405654	CTSD/CTSB/BCL2/IRS1/GABARAPL1/DAPK3/AKT3/ERN1/IRS2/WIPI1	2.1632852179082
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/288	41/9376	3.17615176151762	VEGFA/MMP9/THBS1/DAPK3	2.48583139820887
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/288	170/9376	1.91503267973856	GADD45G/WNT2/WNT10A/ACTG1/APC/SMAD3/AKT3/WNT4/NFE2L2/SMARCC2	2.14325232324888
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/288	148/9376	1.97972972972973	GADD45G/FGF7/WNT2/FGF2/WNT10A/FGF5/APC/AKT3/WNT4	2.13860744567309
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/288	42/9376	3.1005291005291	AOC1/INMT/CYP1B1/MAOB	2.42866252968644
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/288	105/9376	2.17037037037037	GADD45G/BCL2/TNFSF14/CXCL3/LY96/TAB3/VCAM1	2.14685345501962
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/288	105/9376	2.17037037037037	ITGA11/DTNA/TNNI3/DES/ACTG1/TPM4/DMD	2.14685345501962
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/288	63/9376	2.58377425044092	GADD45G/WNT2/WNT10A/APC/WNT4	2.24525914480349
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/288	253/9376	1.67281510759772	C3/ROCK2/VCL/BCL2/ACTG1/AKT3/ACTN4/CAST/FNBP1L/MYL9/CAPN2/TAB3/WIPI1	1.93123392003663
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/288	45/9376	2.89382716049383	ABCA8/ABCA6/ABCA3/ABCD3	2.26688884720436
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/288	86/9376	2.27131782945736	ITGA11/DTNA/DES/ACTG1/GJA1/DMD	2.10835252926163
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/288	109/9376	2.09072375127421	SPP1/TLR8/AKT3/LY96/MAP2K4/CXCL11/IFNAR1	2.03894805025784
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	16/288	333/9376	1.56423089756423	SPP1/ITGA11/COL4A4/HLA-B/HLA-E/TNC/VEGFA/WNT2/WNT10A/APC/THBS1/AKT3/WNT4/IFNAR1/RBL2/ATP6V0A1	1.8662526563054
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/288	89/9376	2.19475655430712	SPP1/ITGA11/CD36/COL4A4/TNC/THBS1	2.0159716716903
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/288	68/9376	2.3937908496732	CYP2W1/ALDH1A1/RDH10/ADH1B/DHRS3	2.0533907483869
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/288	187/9376	1.74093879976233	TXNIP/IFI16/CTSB/BCL2/GABARAPL1/CXCL3/ANTXR2/GBP2/TAB3/IFNAR1	1.82186728732017
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/288	50/9376	2.60444444444444	CD36/SDC2/THBS1/VCAM1	2.0249285483392
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/288	143/9376	1.82128982128982	HLA-DRA/HLA-DQA2/HLA-DRB1/C3/HLA-DPA1/ACTN4/HLA-DMA/HLA-DPB1	1.7617357374575
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/288	194/9376	1.67812142038946	MYH11/TNNI3/ACTA2/ACTG1/DYNLT3/KIF13A/TPM4/MYO1E/DYNC2H1/MYL9	1.69897663634261
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/288	75/9376	2.17037037037037	IGFBP3/GADD45G/BCL2/THBS1/APAF1	1.81149379542255
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/288	248/9376	1.5752688172043	ROCK2/BCL2/ACTG1/DYNLT3/FYCO1/AKT3/DYNC2H1/LY96/MYL9/MAP2K4/TAB3/SNX9	1.63439332928483
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/288	55/9376	2.36767676767677	SPHK1/CERS6/UGT8/SPTLC2	1.81084502131461
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/288	56/9376	2.32539682539683	C3/CXCL3/HSPA6/APAF1	1.7708415613833
Organismal Systems	Immune system	hsa04611	Platelet activation	7/288	126/9376	1.80864197530864	MYLK/ROCK2/RAP1B/ACTG1/FCER1G/AKT3/SNAP23	1.62674099076644
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/288	17/9376	3.83006535947712	CSAD/FMO1	2.07899730081624
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/288	17/9376	3.83006535947712	INMT/PAPSS2	2.07899730081624
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/288	17/9376	3.83006535947712	MYH11/NRP2	2.07899730081624
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/288	103/9376	1.89644012944984	C3/IFNGR2/AKT3/BDKRB2/MAP2K4/IFNGR1	1.62846149828067
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/288	36/9376	2.71296296296296	GCNT1/GALNT15/GCNT4	1.83304660960327
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/288	155/9376	1.68028673835125	RAP1B/WNT2/WNT10A/APC/SCARB1/WNT4/HSD3B2/KMT2A	1.52025543875464
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/288	59/9376	2.20715630885122	IRS1/AKT3/ABHD5/IRS2	1.65576687305642
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/288	157/9376	1.65888181174805	WNT2/WNT10A/ACTG1/APC/SMAD3/GDF6/BMP5/WNT4	1.48205104095939
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/288	184/9376	1.59239130434783	TRPC6/CFL2/ROCK2/SEMA3C/PLXNC1/MYL9/WNT4/DPYSL2/EPHA3	1.44464221476503
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/288	133/9376	1.71345029239766	GADD45G/IRS1/SMAD3/GABARAPL1/AKT3/IRS2/RBL2	1.47513167016468
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/288	133/9376	1.71345029239766	HLA-B/HLA-E/TYROBP/FCER1G/IFNGR2/IFNGR1/IFNAR1	1.47513167016468
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/288	212/9376	1.5356394129979	PDGFC/FGF7/VEGFA/RAP1B/FGF2/FGF5/ACTG1/THBS1/PDGFD/AKT3	1.40425389944075
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/288	110/9376	1.77575757575758	BCL2/VEGFA/IFNGR2/AKT3/EGLN2/IFNGR1	1.45688054214643
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/288	62/9376	2.10035842293907	IRS1/AKT3/HSPA6/IRS2	1.5474250501187
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/288	87/9376	1.87100893997446	GADD45G/BCL2/APC/SMAD3/AKT3	1.45293264034317
NA	NA	hsa04517	IgSF CAM signaling	13/288	299/9376	1.41545893719807	MYLK/TRPC6/MYH11/NRP2/NFASC/CLMP/VCL/RAP1B/ACTG1/AKT3/ACTN4/PMP22/MYL9	1.29969142957456
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/288	21/9376	3.1005291005291	CSAD/ENPP1	1.71539514639886
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	16/288	388/9376	1.34249713631157	MAP3K5/IRS1/RTN4/WNT2/WNT10A/APC/AKT3/NOX4/SLC39A6/WNT4/RTN3/ERN1/CAPN2/IRS2/APAF1/WIPI1	1.22656056729256
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/288	66/9376	1.97306397306397	CYP1B1/HSD17B7/HSD3B2/HSD17B2	1.41216760181212
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/288	43/9376	2.27131782945736	CD36/SCARB1/SLC27A4	1.48739204874703
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/288	22/9376	2.95959595959596	AOC1/MAOB	1.63804910149095
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/288	93/9376	1.75029868578256	COL4A4/GADD45G/BCL2/AKT3/APAF1	1.29443190158023
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/288	254/9376	1.40988626421697	SPHK1/MYLK/PDGFC/FGF7/VEGFA/FGF2/FGF5/PDGFD/HTR2B/HRH1/BDKRB2	1.17891613624285
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/288	120/9376	1.62777777777778	MAP3K5/BCL2/ARHGDIG/RAP1B/IRS1/AKT3	1.23206213708268
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/288	174/9376	1.49680715197957	MAP3K5/BCL2/BAG2/NFE2L2/HSPA6/ERN1/CAPN2/SEC61A2	1.17752211362889
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/288	70/9376	1.86031746031746	CD36/IRS1/AKT3/IRS2	1.28609768321301
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/288	70/9376	1.86031746031746	VEGFA/RAP1B/AKT3/EGLN2	1.28609768321301
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/288	122/9376	1.60109289617486	SLC16A10/DIO3/ACTG1/AKT3/WNT4/NCOR1	1.18960967080585
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/288	71/9376	1.83411580594679	PRLR/SOCS4/AKT3/CISH	1.25587107913582
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/288	47/9376	2.07801418439716	IRS1/SOCS4/IRS2	1.31887483167114
NA	NA	hsa04519	Cadherin signaling	16/288	404/9376	1.28932893289329	DES/ROCK2/CDH13/VCL/WNT2/RERE/WNT10A/ACTG1/APC/GJA1/ACTN4/MYO1E/LHFPL2/DCHS1/WNT4/PCDHA10	1.05824356982663
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/288	100/9376	1.62777777777778	TNFSF14/IL20/CXCL3/IL6ST/CXCL11	1.12350055500018
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/288	323/9376	1.31028551771586	FOXP1/TIMP3/BCL2/PIM1/TNC/VEGFA/MMP9/IRS1/APC/THBS1/CYP1B1/IRS2/MIR145	1.01021596970357
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/288	238/9376	1.36788048552754	PDGFC/FGF7/VEGFA/RAP1B/ETS2/FGF2/FGF5/PDGFD/AKT3/RASA4	1.02333393372331
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/288	75/9376	1.7362962962963	MAP3K5/BCL2/AKT3/APAF1	1.13963597003166
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/288	51/9376	1.91503267973856	ACTG1/SEC61A2/ATP6V0A1	1.16639324429793
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/288	103/9376	1.58036677454153	SLC16A10/COL4A4/COL12A1/COL8A1/SLC38A2	1.0542867461793
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/288	130/9376	1.5025641025641	COL4A4/ACTA2/VEGFA/MMP9/AKT3/MAP2K4	1.02715011433306
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/288	77/9376	1.69119769119769	GADD45G/VEGFA/SMAD3/AKT3	1.08411971045112
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/288	300/9376	1.30222222222222	MAP3K5/GADD45G/PDGFC/FGF7/VEGFA/RAP1B/FGF2/FGF5/PDGFD/AKT3/HSPA6/MAP2K4	0.947081822585304
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/288	158/9376	1.44233473980309	MAPKAP1/IRS1/WNT2/WNT10A/AKT3/LPIN2/WNT4	0.998180229012057
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/288	78/9376	1.66951566951567	C3/CFL2/SERPING1/LY96	1.05696595565275
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/288	106/9376	1.5356394129979	PDGFC/BCL2/MMP9/PDGFD/AKT3	0.987264029271362
NA	NA	hsa04081	Hormone signaling	9/288	219/9376	1.337899543379	PTHLH/SLC16A10/RAMP1/RAMP3/CSH2/IRS1/CSH1/PRLR/IRS2	0.900701276239938
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/288	163/9376	1.39809134287662	BCL2/MMP9/SMAD3/AKT3/MAP2K4/IFNAR1/APAF1	0.91269090499007
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	10/288	250/9376	1.30222222222222	CTSD/CTSB/CTSS/TLR8/SNAPIN/VPS26A/ARSG/VPS26B/ATP6V0A1/CD68	0.862191802961346
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/288	109/9376	1.49337410805301	CD36/IRS1/AKT3/IRS2/SLC27A4	0.922290519929717
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/288	56/9376	1.74404761904762	GAS1/BCL2/SMURF1	0.99411015796218
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/288	32/9376	2.03472222222222	GABARAPL1/WIPI1	1.04371055018859
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/288	32/9376	2.03472222222222	BCL2/APAF1	1.04371055018859
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/288	168/9376	1.35648148148148	BCL2/IFNGR2/GLUL/IFNGR1/CAPN2/IFNAR1/FTL	0.829959083559494
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/288	140/9376	1.3952380952381	SPP1/SPHK1/MYLK/ACTA2/SMAD3/AKT3	0.838742358057454
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	7/288	170/9376	1.34052287581699	MYH11/MAP3K5/ROCK2/ACTG1/ACTN4/MYL9/CLDN10	0.797596043151903
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/288	10/9376	3.25555555555556	PAPSS2	1.27035228954121
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/288	59/9376	1.65536723163842	GADD45G/APC/AKT3	0.898918676791939
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/288	201/9376	1.29574350469873	IGFBP3/GADD45G/MMP9/PBX3/KLF3/NCOR1/CDK9/KMT2A	0.754497717527709
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/288	60/9376	1.62777777777778	SPHK1/VEGFA/AKT3	0.868389465864641
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/288	89/9376	1.46317103620474	PDGFC/GJA1/PDGFD/HTR2B	0.781531337719019
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/288	89/9376	1.46317103620474	HAP1/GABARAPL1/GLUL/SLC38A2	0.781531337719019
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/288	178/9376	1.28027465667915	ROCK2/WNT2/WNT10A/APC/SMAD3/MCC/WNT4	0.672039578387643
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/288	37/9376	1.75975975975976	ADH1B/MAOB	0.824279852857369
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/288	37/9376	1.75975975975976	GADD45G/TPR	0.824279852857369
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/288	122/9376	1.33424408014572	CD36/FBP1/IRS1/AKT3/IRS2	0.661495074523861
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/288	67/9376	1.45771144278607	FBP1/ADH1B/ADPGK	0.669307018322993
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/288	217/9376	1.20020481310804	BCL2/VDR/FGF7/VEGFA/FGF2/FGF5/CYP1B1/AKT3	0.531163317128059
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/288	98/9376	1.32879818594104	SPHK1/CFL2/GSN/AKT3	0.582455820333305
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/288	69/9376	1.41545893719807	FCER1G/AKT3/MAP2K4	0.616588637233918
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/288	41/9376	1.58807588075881	SDS/MAOB	0.671762656801152
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	9/288	250/9376	1.172	HLA-B/HLA-E/SMAD3/VPS26A/HSPA6/VPS26B/ARFGAP3/STAM2/SMURF1	0.490688570214766
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/288	99/9376	1.31537598204265	BCL2/MMP9/AKT3/NCOR1	0.561552231987955
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/288	71/9376	1.37558685446009	CXCL3/MAP2K4/ATP6V0A1	0.565495420248773
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/288	15/9376	2.17037037037037	ST3GAL5	0.807524203839554
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/288	43/9376	1.51421188630491	ADH1B/ACADSB	0.601607759554183
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/288	73/9376	1.337899543379	ADH1B/FMO1/MAOB	0.515923425392259
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/288	103/9376	1.26429341963323	COL4A4/VCL/CXCL3/ACTN4	0.480111994077936
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/288	16/9376	2.03472222222222	MAOB	0.737383755951873
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/288	44/9376	1.47979797979798	ARHGDIG/DYNC2H1	0.567865011850231
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/288	136/9376	1.1968954248366	BCL2/AKT3/HSPA6/IFNAR1/APAF1	0.411734080364481
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/288	17/9376	1.91503267973856	GLUL	0.672193122665759
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/288	76/9376	1.28508771929825	CD36/SLC27A4/OLR1	0.444213296900608
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/288	138/9376	1.17954911433172	FBP1/IRS1/SOCS4/AKT3/IRS2	0.378252279859765
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/288	77/9376	1.26839826839827	GADD45G/SMAD3/AKT3	0.420973415749287
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/288	139/9376	1.17106314948042	CTSD/BCL2/MMP9/AKT3/HSPA6	0.361698006262604
NA	NA	hsa03272	Virion - Hepatitis viruses	2/288	48/9376	1.35648148148148	SCARB1/CLDN10	0.44076900468554
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/288	205/9376	1.11165311653117	C3/HLA-B/HLA-E/GSN/ACTN4/IL6ST/RBL2	0.287731332246406
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/288	205/9376	1.11165311653117	CD36/TNNI3/CTSD/MMP9/IRS1/SMAD3/AKT3	0.287731332246406
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/288	142/9376	1.14632237871674	TYROBP/IFNGR2/AKT3/IFNGR1/IFNAR1	0.312757485393721
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/288	50/9376	1.30222222222222	AOC1/MAOB	0.381426984174696
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/288	20/9376	1.62777777777778	HSD17B7	0.500291993383881
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/288	83/9376	1.17670682730924	PHC2/CBX7/ASXL2	0.287847279957096
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/288	52/9376	1.25213675213675	CD36/SCARB1	0.324552094740212
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/288	21/9376	1.55026455026455	DSE	0.449373035832446
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/288	149/9376	1.09246830723341	SPHK1/PDGFC/FCER1G/PDGFD/AKT3	0.202536594843431
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/288	53/9376	1.22851153039832	VDR/BDKRB2	0.296972294505293
NA	NA	hsa04382	Cornified envelope formation	7/288	217/9376	1.05017921146953	COL4A4/DST/ABHD5/CLDN10/S100A16/SPTLC2/SLC27A4	0.133130447771227
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/288	23/9376	1.41545893719807	GLUL	0.355111126087724
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/288	23/9376	1.41545893719807	ATP6AP2	0.355111126087724
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/288	154/9376	1.05699855699856	MYLK/ROCK2/ACTG1/MYL9/RGS2	0.126957799207018
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/288	156/9376	1.04344729344729	AKT3/SCARB1/CLDN10/IFNAR1/APAF1	0.0974108400814007
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/288	90/9376	1.08518518518519	IRS1/AKT3/IRS2	0.144550204297367
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/288	90/9376	1.08518518518519	IFNGR2/AKT3/IFNGR1	0.144550204297367
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/288	157/9376	1.03680113234253	SPHK1/CD36/AXL/THBS1/ATP11B	0.0827783610417702
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/288	157/9376	1.03680113234253	MAP3K5/IRS1/AKT3/ERN1/IRS2	0.0827783610417702
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/288	158/9376	1.03023909985935	GADD45G/SMAD3/ESCO1/E2F4/RBL2	0.0682380760691868
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/288	227/9376	1.00391581008321	MAP3K5/VEGFA/CYP1B1/AKT3/NOX4/NFE2L2/MAP2K4	0.0106315223877033
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/288	94/9376	1.03900709219858	MMP9/CXCL3/TAB3	0.0676603818559229
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/288	26/9376	1.25213675213675	SCARB1	0.229173683750575
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/288	61/9376	1.06739526411658	VDR/FTL	0.0940049213505341
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/288	63/9376	1.03350970017637	PHYKPL/KMT2A	0.0475054830192276
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/288	200/9376	0.976666666666667	MYH11/ROCK2/ACTG1/MYO1E/TAB3/CLDN10	-0.0593762551949884
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/288	28/9376	1.16269841269841	ATP6V0A1	0.153479615542491
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/288	99/9376	0.986531986531987	HTR2B/HRH1/BDKRB2	-0.0239808782343612
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/288	99/9376	0.986531986531987	PDGFC/PDGFD/AKT3	-0.0239808782343612
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/288	29/9376	1.12260536398467	DCHS1	0.117711819156606
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/288	65/9376	1.0017094017094	SCARB1/HSD3B2	0.00246178642091261
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/288	65/9376	1.0017094017094	SPP1/AKT3	0.00246178642091261
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/288	101/9376	0.966996699669967	WNT2/WNT10A/WNT4	-0.0593620406714448
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/288	138/9376	0.943639291465379	ROCK2/ACTG1/AKT3/MAP2K4	-0.118733899507549
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/288	31/9376	1.05017921146953	FBP1	0.0498152999162831
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/288	31/9376	1.05017921146953	CSAD	0.0498152999162831
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/288	31/9376	1.05017921146953	GLUL	0.0498152999162831
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/288	31/9376	1.05017921146953	SEC61A2	0.0498152999162831
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/288	68/9376	0.957516339869281	PIM1/AKT3	-0.0625886980750988
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/288	105/9376	0.93015873015873	GABARAPL1/CCZ1/SMURF1	-0.12811241232486
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/288	142/9376	0.917057902973396	KLHL9/UBE2R2/TRIP12/SMURF1	-0.177284991720504
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/288	33/9376	0.986531986531987	SNAP23	-0.0137963772232295
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	6/288	214/9376	0.912772585669782	HLA-B/HLA-E/CFL2/BCL2/AKT3/B2M	-0.229780126814813
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/288	144/9376	0.904320987654321	MAP3K5/AKT3/ERN1/WIPI1	-0.205967052792121
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/288	34/9376	0.957516339869281	POLR3D	-0.0441762834379845
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/288	34/9376	0.957516339869281	FBXL3	-0.0441762834379845
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/288	73/9376	0.89193302891933	MDFIC/CDK9	-0.165002536949776
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/288	73/9376	0.89193302891933	GADD45G/AKT3	-0.165002536949776
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/288	35/9376	0.93015873015873	FBP1	-0.0736880707142796
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/288	36/9376	0.904320987654321	ENPP1	-0.102386387203066
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/288	75/9376	0.868148148148148	SDS/GLUL	-0.204079680750135
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/288	76/9376	0.85672514619883	MYLK/ACTG1	-0.223245656903896
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/288	76/9376	0.85672514619883	GADD45G/AKT3	-0.223245656903896
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/288	37/9376	0.87987987987988	GLUL	-0.130320925352944
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/288	37/9376	0.87987987987988	VCAM1	-0.130320925352944
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/288	115/9376	0.849275362318841	BCL2/AKT3/SLC18A3	-0.289502254091227
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/288	115/9376	0.849275362318841	KCND2/HTR2B/MAOB	-0.289502254091227
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/288	115/9376	0.849275362318841	PTHLH/BCL2/VDR	-0.289502254091227
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/288	38/9376	0.85672514619883	ENPP1	-0.15753699619133
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/288	38/9376	0.85672514619883	IRS1	-0.15753699619133
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/288	78/9376	0.834757834757835	ITPK1/SYNJ2	-0.26086819331004
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/288	78/9376	0.834757834757835	VCL/ACTG1	-0.26086819331004
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/288	116/9376	0.841954022988506	SDS/FBP1/ADPGK	-0.304898066082086
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/288	116/9376	0.841954022988506	DLGAP1/GLUL/SLC38A2	-0.304898066082086
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/288	154/9376	0.845598845598846	TNNI3/BCL2/AKT3/TPM4	-0.343911000383567
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/288	117/9376	0.834757834757835	ACTG1/CHD3/SMARCC2	-0.320169154276515
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/288	227/9376	0.860499265785609	HLA-B/HLA-E/ROCK2/VEGFA/AKT3/B2M	-0.378747985061924
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/288	79/9376	0.824191279887482	ADH1B/CYP1B1	-0.279338158210176
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/288	79/9376	0.824191279887482	SLC18A3/ATP6V0A1	-0.279338158210176
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	5/288	193/9376	0.843408175014393	ROCK2/RAP1B/AKT3/CXCL3/CXCL11	-0.391293983993893
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/288	83/9376	0.784471218206158	IFI16/POLR3D	-0.351086455099185
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/288	42/9376	0.775132275132275	FTL	-0.25999535897147
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/288	86/9376	0.757105943152455	AKT3/MAP2K4	-0.402815320631287
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/288	44/9376	0.73989898989899	MGAT2	-0.30784261168723
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/288	44/9376	0.73989898989899	TAF8	-0.30784261168723
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/288	44/9376	0.73989898989899	PARP4	-0.30784261168723
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/288	87/9376	0.748403575989783	TNNI3/TPM4	-0.419688753882118
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/288	46/9376	0.707729468599034	FTL	-0.353729146389535
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/288	47/9376	0.692671394799054	ADH1B	-0.375995017800982
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/288	91/9376	0.715506715506716	AKT3/CD72	-0.485455565352282
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/288	48/9376	0.678240740740741	ACADSB	-0.397836958774611
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/288	48/9376	0.678240740740741	AKT3	-0.397836958774611
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/288	49/9376	0.664399092970521	GALNT15	-0.419273969750522
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/288	49/9376	0.664399092970521	MAOB	-0.419273969750522
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/288	368/9376	0.796195652173913	MAP3K5/BCL2/ACTG1/HAP1/ANG/ERN1/TPR/APAF1/WIPI1	-0.710020500279098
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/288	370/9376	0.791891891891892	C3/P2RY14/CSH2/CSH1/HTR2B/PRLR/HRH1/S1PR3/BDKRB2	-0.727062281165675
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/288	98/9376	0.664399092970521	ITPK1/SYNJ2	-0.594506630409166
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/288	98/9376	0.664399092970521	SCARB1/HSD3B2	-0.594506630409166
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	12/288	480/9376	0.813888888888889	MAP3K5/BCL2/WNT2/WNT10A/APC/HAP1/NOX4/WNT4/ERN1/CAPN2/APAF1/WIPI1	-0.74514922894954
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/288	54/9376	0.602880658436214	SDS	-0.520968054330487
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/288	54/9376	0.602880658436214	WDR48	-0.520968054330487
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/288	56/9376	0.581349206349206	MGAT2	-0.559352648880054
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	5/288	226/9376	0.720255653883972	TNNI3/ROCK2/RAP1B/AKT3/MYL9	-0.757796706171588
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/288	57/9376	0.571150097465887	ACADSB	-0.578103782004173
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/288	104/9376	0.626068376068376	LPCAT2/LPIN2	-0.682605646888583
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	6/288	268/9376	0.728855721393035	MAP3K5/SLC39A6/NFE2L2/ERN1/APAF1/MAOB	-0.801685546452377
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/288	105/9376	0.62010582010582	FCER1G/AKT3	-0.69685387916098
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/288	59/9376	0.551789077212806	ENPP1	-0.614777715737016
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/288	107/9376	0.608515057113188	FBP1/AKT3	-0.725000379231067
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/288	108/9376	0.602880658436214	THOC2/TPR	-0.738903336868641
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/288	195/9376	0.667806267806268	C3/ACTG1/TLR8/AKT3	-0.834471423493776
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/288	62/9376	0.525089605734767	NCOR2	-0.66786260306426
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/288	63/9376	0.516754850088183	PTGIS	-0.685079070908861
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	5/288	238/9376	0.683940242763772	RPS4Y1/C3/TLR8/IL6ST/IFNAR1	-0.879184102957716
NA	NA	hsa04082	Neuroactive ligand signaling	4/288	199/9376	0.654383026242323	P2RY14/HTR2B/HRH1/SLC18A3	-0.877241074993599
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/288	65/9376	0.500854700854701	LPIN2	-0.718841634906473
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/288	67/9376	0.485903814262023	RAP1B	-0.751757882899014
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/288	69/9376	0.471819645732689	CTSB	-0.783880127956298
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/288	69/9376	0.471819645732689	MAOB	-0.783880127956298
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/288	70/9376	0.465079365079365	CYP1B1	-0.79965852258816
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/288	71/9376	0.458528951486698	AKT3	-0.815255897525314
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/288	128/9376	0.508680555555556	PAPSS2/ENPP1	-0.99630600809489
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/288	133/9376	0.489557226399332	AKT3/MAOB	-1.05539279914592
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/288	83/9376	0.392235609103079	ABCD3	-0.990020190155466
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/288	85/9376	0.383006535947712	ENPP1	-1.01720039276592
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/288	86/9376	0.378552971576227	KCNMB1	-1.03060728310452
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/288	90/9376	0.361728395061728	SCARB1	-1.08307906698172
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/288	93/9376	0.350059737156511	MAP2K4	-1.1212913287574
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/288	93/9376	0.350059737156511	LYZ	-1.1212913287574
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/288	102/9376	0.31917211328976	RAP1B	-1.23069829559614
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	5/288	308/9376	0.528499278499278	MAP3K5/HAP1/ERN1/APAF1/WIPI1	-1.49778572477766
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/288	110/9376	0.295959595959596	AKT3	-1.32219497119279
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	3/288	235/9376	0.415602836879433	MAP3K5/ACTG1/SMARCC2	-1.61507575838194
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/288	122/9376	0.266848816029144	AKT3	-1.45096331060411
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/288	138/9376	0.235909822866345	ATP6V0A1	-1.60969243760949
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/288	154/9376	0.211399711399711	DHRS3	-1.75651739915532
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/288	243/9376	0.267946959304984	HSPA6/THOC2	-2.05819576264671
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/288	191/9376	0.170447934845841	MAOB	-2.06190416088412
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	2/288	275/9376	0.236767676767677	HSPA6/APAF1	-2.28678990984304
Genetic Information Processing	Translation	hsa03010	Ribosome	1/288	222/9376	0.146646646646647	RPS4Y1	-2.29059155655198
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/288	449/9376	0.0725068052462262	RGS2	-3.5853277109241