category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	35/396	233/9376	3.55659600294793	DCN/VIM/COL3A1/COL1A2/DES/TNNT1/FN1/ATP1B1/COL1A1/COL6A1/FMNL2/COL5A2/CSRP2/FHL1/COL5A1/FBN1/BGN/TNNI3/SDC2/SGCE/COL6A2/THBS1/COL9A3/TNNT3/PDLIM3/COL11A1/FLNC/FHL3/ITGA7/SNTB1/ATP1A2/ELN/LMNA/SUN1/THBS3	8.29833129193279
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	21/396	103/9376	4.8273021476905	COL3A1/COL1A2/COL15A1/COL14A1/ATP1B1/COL1A1/COL16A1/COL6A1/COL5A2/SLC16A10/COL5A1/SLC38A2/COL8A2/COL6A2/COL12A1/COL9A3/COL11A1/COL17A1/ATP1A2/ELN/SLC7A7	8.2015567516908
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/396	44/9376	7.53351698806244	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-F/CPE/FAS	9.12181081248805
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/396	70/9376	5.75007215007215	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRB1/ITGB2/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/SGCE/HLA-DQB1/HLA-F/CXADR/ABL1/SNTB1	8.37650332119429
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/396	39/9376	7.89225589225589	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-F/FAS	9.05701485971491
NA	NA	hsa04518	Integrin signaling	25/396	154/9376	3.84363111635839	SPP1/COL1A2/FN1/CCND2/COL1A1/VCAM1/COL6A1/ITGB2/HGF/FBN1/COL6A2/THBS1/COL9A3/VTN/TNC/VEGFA/NPNT/PDGFA/FREM2/ITGA7/LAMB2/PDGFRA/THBS3/FERMT3/PDGFC	7.47164316001297
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	30/396	224/9376	3.17099567099567	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/CCND2/HLA-DPB1/HLA-DRB1/ITGB2/MSX1/CREB3L1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/CDKN1A/HLA-DQB1/HLA-F/TGFBR1/MMP7/ADCY3/SMAD3/SPI1/EGR1/NRP1/TGFB3/TNFRSF1A/NFATC2/MAPK1/ATF2/CREBBP	6.90589584054706
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/396	45/9376	6.83995510662177	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-F/FAS	8.24606461566305
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/396	110/9376	4.3048668503214	DCN/PITX2/EMP3/FBN1/THBS1/BMP5/ACVR2A/FST/TGFBR1/SMAD3/FMOD/HAMP/SKIL/SMAD7/TGFB3/ZFYVE16/SMAD5/MAPK1/SMAD6/CREBBP	7.32148579951959
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	26/396	181/9376	3.40108264970143	HLA-DRA/CTSD/CD74/HLA-DPA1/CTSS/HLA-DPB1/MRC2/HLA-DRB1/FCER1G/FCGR3A/ITGB2/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/ARHGEF12/SPHK1/IL18/TGFB3/TNFRSF1A/CALM2/LSP1/CAMK2D/MAPK1/CREBBP	6.84960603301325
Human Diseases	Immune disease	hsa05310	Asthma	11/396	32/9376	8.13888888888889	HLA-DRA/PRG2/HLA-DPA1/HLA-DPB1/HLA-DRB1/FCER1G/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1	8.49443034932326
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/396	82/9376	4.90859817689086	HLA-DRA/HLA-B/CD74/HLA-A/HLA-DPA1/CTSS/CTSB/HLA-DPB1/HLA-DRB1/LGMN/HSPA1A/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-F	7.46486022213481
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	18/396	95/9376	4.48612440191388	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/ITGB2/ACP5/CXCL2/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/CXCL3/CSF1/HLA-DQB1/TNFSF13B/VEGFA/IL18/TGFB3	7.17137379532171
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/396	204/9376	3.13368983957219	DCN/TIMP3/COL1A2/IGF2/FN1/LUM/COL1A1/MMP9/CD44/HGF/GPC3/SDC2/FZD2/THBS1/CDKN1A/VTN/FZD1/WNT2/WNT5B/PLAUR/PLCE1/VEGFA/ARHGEF12/PPP1R12B/CAMK2D/MAPK1/FAS	6.47007645549777
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	17/396	88/9376	4.57392102846648	SERPINE2/F3/SERPINE1/C7/CLU/ITGB2/A2M/F10/C1QA/C1QB/CFH/PROS1/VTN/PLAT/PLAUR/C3AR1/C5AR1	7.07327018150796
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/396	89/9376	4.52252865736012	SPP1/COL1A2/FN1/COL1A1/CD36/COL6A1/CD44/COL6A2/THBS1/COL9A3/VTN/TNC/NPNT/FREM2/ITGA7/LAMB2/THBS3	7.01143445306689
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/396	54/9376	5.69996258885148	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-F/FAS	7.27330491169623
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/396	66/9376	5.0223446587083	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/MAF/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/SMAD3/IL18/TGFB3/STAT6	6.88607059840425
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	22/396	155/9376	3.36057347670251	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/CTSS/CD36/HLA-DPB1/MRC2/HLA-DRB1/MSR1/FCGR3A/ITGB2/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/THBS1/NCF2/HLA-DQB1/HLA-F/OLR1/THBS3	6.22285131017543
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/396	99/9376	4.0657075808591	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/FCGR3A/ITGB2/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/C1QA/C1QB/CFH/FPR3/HLA-DQB1/C3AR1/C5AR1	6.43931409681903
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	17/396	109/9376	3.69270688536744	HLA-DRA/IL6ST/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/TGFBR1/SMAD3/IL6R/AHR/STAT6/NFATC2/MAPK1	5.93783070482398
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/396	78/9376	4.24967624967625	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/FCGR3A/ITGB2/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/NCF2/HLA-DQB1/TGFB3/MAPK1	6.05184351296157
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	24/396	203/9376	2.79922376474101	SPP1/COL1A2/FN1/CCND2/COL1A1/COL6A1/HGF/EMP2/COL6A2/THBS1/COL9A3/VTN/TNC/VEGFA/CAPN2/BIRC3/PDGFA/PPP1R12B/ITGA7/LAMB2/PDGFRA/THBS3/MAPK1/PDGFC	5.44217576247834
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/396	50/9376	5.20888888888889	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/CXCR4/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/TNFSF13B	6.26613605438328
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/396	93/9376	3.81883349625285	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/MAF/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/RBPJ/MAML2/STAT6/NFATC2/MAPK1	5.73669532873341
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	34/396	362/9376	2.22378480942017	SPP1/COL1A2/CSH1/IGF2/FN1/CCND2/COL1A1/PRLR/COL6A1/CSH2/HGF/CREB3L1/FOXO3/COL6A2/THBS1/CSF1/COL9A3/FGFR2/CDKN1A/VTN/EREG/TNC/VEGFA/PDGFA/IL6R/OSM/ITGA7/LAMB2/PDGFRA/EFNA5/THBS3/MAPK1/ATF2/PDGFC	4.98649777184703
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	20/396	160/9376	2.95959595959596	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRB1/VCAM1/ITGB2/ALCAM/HLA-DMB/HLA-DMA/SDC2/HLA-DQA1/HLA-DQA2/CLDN15/HLA-DQB1/HLA-F/CXADR/CADM1/VTCN1	5.24989184519577
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	16/396	112/9376	3.38239538239538	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HSPA1A/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/BIRC3/LY96/TGFB3/TNFRSF1A/LAMB2/MAPK1	5.32621434107707
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/396	100/9376	3.55151515151515	HLA-DRA/HLA-DPA1/CD36/HLA-DPB1/HLA-DRB1/CD44/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/CSF1/HLA-DQB1/CD9/IL6R/CD37	5.38657665385787
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	19/396	157/9376	2.86534131120118	HLA-B/HLA-A/CCND2/SERPINE1/IGFBP3/GADD45B/ZFP36L2/FOXO3/CDKN1A/HLA-F/TGFBR1/SMAD3/CAPN2/HIPK2/TGFB3/CALM2/HIPK1/NFATC2/MAPK1	4.94949956114889
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/396	50/9376	4.73535353535354	CD36/VCAM1/ITGB2/HGF/SDC2/THBS1/CD81/IL18/TGFB3/THBS3	5.56114311440658
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	30/396	333/9376	2.13304213304213	SPP1/HLA-B/COL1A2/HLA-A/FN1/CCND2/COL1A1/COL6A1/CREB3L1/COL6A2/FZD2/THBS1/COL9A3/CDKN1A/VTN/HLA-F/FZD1/WNT2/WNT5B/TNC/RBPJ/MAML2/VEGFA/TNFRSF1A/ITGA7/LAMB2/THBS3/MAPK1/FAS/CREBBP	4.42086215837426
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/396	101/9376	3.28192819281928	COL3A1/COL1A2/FN1/F3/SERPINE1/COL1A1/VCAM1/TGFBR1/SMAD3/EGR1/PLCE1/VEGFA/TGFB3/MAPK1	4.84173219994528
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/396	184/9376	2.44488361879666	SLIT3/SLIT2/EPHA3/CXCR4/TRPC6/EFNB2/ENAH/SEMA6D/WNT5B/NRP1/ARHGEF12/SEMA3A/ABL1/NFATC2/CAMK2D/EFNA5/EPHB6/MAPK1/RYK	4.15653875183405
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/396	142/9376	2.66780480864988	GSTT1/VCAM1/MMP9/DUSP1/SDC2/GSTM3/NCF2/ACVR2A/PLAT/VEGFA/PDGFA/MEF2A/TNFRSF1A/CALM2/NFE2L2/KLF2	4.20522774954181
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/396	298/9376	2.06575825367772	IL6ST/CSH1/PRLR/CSH2/CXCL14/TNFRSF12A/CXCL2/CXCR4/CXCL3/CSF1/CCL18/BMP5/TNFSF13B/ACVR2A/TGFBR1/IL18/TGFB3/TNFRSF1A/IL6R/OSM/CCL7/CXCL16/IL1RN/TNFSF15/FAS/IL34	3.92614929841155
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/396	80/9376	3.25555555555556	HGF/GAS6/FOXO3/FGFR2/AXL/VEGFA/PDGFA/IL6R/PDGFRA/MAPK1/PDGFC	4.25447060403188
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/396	178/9376	2.39427987742594	CCND2/RSPO3/FZD2/RSPO2/SFRP2/MCC/MMP7/FZD1/SMAD3/WNT2/WNT5B/FRZB/PRICKLE1/DKK2/NFATC2/CAMK2D/CREBBP/RYK	3.94374041384267
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/396	100/9376	2.84121212121212	IL6ST/CXCL14/CXCL2/CXCR4/CXCL3/CSF1/CCL18/IL18/TNFRSF1A/IL6R/CCL7/IL34	3.88703559962475
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	19/396	205/9376	2.19443212613944	HLA-DRA/VIM/HLA-B/HLA-A/HLA-DPA1/CCND2/HLA-DPB1/HLA-DRB1/GADD45B/CD44/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/CDKN1A/HLA-DQB1/HLA-F/RBPJ/FAS	3.63099058279837
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/396	75/9376	3.15690235690236	CCND2/SERPINE1/IGFBP3/GADD45B/THBS1/CDKN1A/CD82/SESN3/FAS/SESN1	3.93814186979606
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	17/396	180/9376	2.2361391694725	HLA-DRA/HLA-B/CD74/HLA-A/HLA-DPA1/HLA-DPB1/HLA-DRB1/BST2/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-F/BIRC3/TNFRSF1A/FAS	3.51640753658399
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/396	137/9376	2.41952370419524	CTSD/CTSS/CTSB/GADD45B/CTSC/CTSZ/CAPN2/BIRC3/TNFRSF1A/CTSO/LMNA/BCL2A1/MAPK1/FAS	3.51467774896129
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	16/396	170/9376	2.22840166369578	IGF2/GSTT1/GADD45B/HGF/FZD2/GSTM3/CDKN1A/TGFBR1/FZD1/SMAD3/WNT2/WNT5B/TGFB3/SMARCC2/NFE2L2/MAPK1	3.39409844055049
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	15/396	157/9376	2.26211156147462	CD36/GAS6/C1QA/THBS1/C1QB/LIPA/PROS1/DUSP2/AXL/SPHK1/CASP1/NFATC2/CAMK2D/HAVCR2/MAPK1	3.34888879698747
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	15/396	166/9376	2.13946695874407	ATP1B1/CREB3L1/TRPC6/PDE5A/RGS2/ADCY3/KCNMA1/MEF2A/CALM2/ATP1A2/NFATC2/ADRB3/MAPK1/GUCY1A2/ATF2	3.1104342695674
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	18/396	216/9376	1.97306397306397	CD36/VCAM1/MMP9/HSPA1A/CXCL2/CXCL3/NCF2/OLR1/LY96/IL18/TNFRSF1A/CALM2/CASP1/NFE2L2/NFATC2/CAMK2D/MAPK1/FAS	3.03819465254401
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	17/396	201/9376	2.00251268907985	CCND2/IGFBP3/MMP9/GADD45B/MAF/RUNX1T1/HPGD/CDKN1A/PLAT/SPI1/BIRC3/PDGFA/NR4A3/MLLT3/JMJD1C/CDK14/BCL2A1	3.01703211717499
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/396	52/9376	3.18725718725719	APOE/APOC1/CD36/LPL/LIPA/CYP27A1/ANGPTL4	3.32120325206496
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	15/396	173/9376	2.05289893151165	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DQB1/IL18/TNFRSF1A/CASP1/MAPK1/FAS/CREBBP	2.93521615023059
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/396	157/9376	2.11130412404298	CCND2/SERPINE1/ITGB2/FZD2/BMP5/TGFBR1/FZD1/SMAD3/WNT2/WNT5B/YAP1/BIRC3/SMAD7/TGFB3	2.94873610594711
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/396	41/9376	3.46489283074649	MMP9/THBS1/CDKN1A/VEGFA/DAPK1/MAPK1	3.32145116706293
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/396	143/9376	2.1524334251607	HLA-DRA/HLA-DPA1/C7/HLA-DPB1/HLA-DRB1/FCGR3A/HLA-DMB/HLA-DMA/HLA-DQA1/HLA-DQA2/C1QA/C1QB/HLA-DQB1	2.91613422402801
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/396	144/9376	2.1374859708193	IL6ST/HAND1/FZD2/FGFR2/ACVR2A/FZD1/SMAD3/WNT2/WNT5B/KLF4/SKIL/SMAD5/MAPK1	2.88851388792563
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/396	98/9376	2.41599670171099	ATP1B1/CREB3L1/ADCY3/HSD3B2/CALM2/ATP1A2/CAMK2D/ATF2/NR4A2/KCNK3	2.95898768948621
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/396	232/9376	1.83699059561129	FN1/C7/RGCC/ITGB2/TMSB4X/CXCR4/FGFR2/ENAH/IQGAP2/ARHGEF12/PDGFA/PPP1R12B/ITGA7/PFN2/PDGFRA/MAPK1/GSN/PDGFC	2.71076284827931
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/396	101/9376	2.34423442344234	CREB3L1/FZD2/ADCY3/FZD1/WNT2/WNT5B/CALM2/CAMK2D/MAPK1/CREBBP	2.85215946441095
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/396	133/9376	2.13624971519708	CCND2/GABARAPL2/GADD45B/FOXO3/CDKN1A/TGFBR1/SMAD3/GABARAP/TGFB3/KLF2/MAPK1/CREBBP	2.77132968784755
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/396	150/9376	2.05198653198653	GADD45B/HGF/FZD2/FGFR2/CDKN1A/TGFBR1/FZD1/SMAD3/WNT2/WNT5B/RARB/TGFB3/MAPK1	2.7273705521088
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/396	119/9376	2.18860877684407	VCAM1/MMP9/CREB3L1/CXCL2/CXCL3/CSF1/BIRC3/TNFRSF1A/MAPK1/ATF2/FAS	2.74013742576312
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	16/396	205/9376	1.84794284306479	CTSD/COL3A1/COL1A2/COL1A1/CD36/MMP9/PDK4/MT-ND2/TNNI3/NCF2/TGFBR1/SMAD3/REN/TGFB3/CAMK2D/MT-ND5	2.577687262876
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/396	106/9376	2.23365732799695	MMP9/CREB3L1/FGFR2/CDKN1A/PLAT/PDGFA/PDGFRA/MAPK1/CREBBP/PDGFC	2.68227110536337
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/396	155/9376	1.98579341805148	CREB3L1/FZD2/CDKN1A/ADCY3/FZD1/WNT2/WNT5B/HSD3B2/AHR/CAMK2D/MAPK1/ATF2/KCNK3	2.59870998451326
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/396	140/9376	2.02943722943723	SPP1/SERPINE1/TGFBR1/ADCY3/SMAD3/PLAT/EGR1/SPHK1/MEF2A/CALM2/KLF2/MAPK1	2.57701525209834
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	17/396	227/9376	1.77315000222489	HLA-B/HLA-A/CREB3L1/CXCR4/CDKN1A/HLA-F/ADCY3/VEGFA/ARHGEF12/TNFRSF1A/IL6R/CALM2/PDGFRA/NFATC2/MAPK1/ATF2/FAS	2.47619555178779
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	21/396	300/9376	1.65737373737374	IGF2/GADD45B/DUSP1/HGF/HSPA1A/CSF1/FGFR2/DUSP2/EREG/TGFBR1/VEGFA/PDGFA/TGFB3/TNFRSF1A/MAPKAPK3/PDGFRA/EFNA5/MAPK1/ATF2/FAS/PDGFC	2.43008125968493
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/396	212/9376	1.78692586239756	ITGB2/HGF/THBS1/CSF1/FGFR2/ENAH/ADCY3/PLCE1/VEGFA/PDGFA/CALM2/PFN2/PDGFRA/EFNA5/MAPK1/PDGFC	2.43362843830127
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/396	115/9376	2.05884936319719	CREB3L1/CDKN1A/ADCY3/EGR1/MMP16/MAFB/MEF2A/MAPK1/ATF2/NR4A2	2.3991048056145
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/396	133/9376	1.95822890559733	HLA-B/HLA-A/TYROBP/FCER1G/FCGR3A/ITGB2/HCST/NFATC2/SH3BP2/MAPK1/FAS	2.33713432735596
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	13/396	168/9376	1.83213083213083	IL6ST/CSH1/CCND2/PRLR/CSH2/FHL1/CDKN1A/PDGFA/IL6R/OSM/STAT6/PDGFRA/CREBBP	2.28538126163092
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/396	69/9376	2.40199092373005	CTSB/REN/KCNMA1/AQP1/CALM2/ADRB3/GUCY1A2	2.4544825752669
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/396	187/9376	1.77259223248528	TXNIP/CTSB/NLRP1/GABARAPL2/CXCL2/CXCL3/ANTXR1/GABARAP/BIRC3/IL18/CASP1/NEK7/MAPK1/IFI16	2.24094954158954
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/396	55/9376	2.58292011019284	PSAP/UGCG/ASAH1/SPHK1/SGMS2/HEXB	2.47231697192581
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/396	86/9376	2.2024900164435	ATP1B1/CREB3L1/ADCY3/KCNMA1/GCK/ATP1A2/CAMK2D/ATF2	2.35243650870091
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/396	103/9376	2.06884377758164	COL3A1/COL1A2/FN1/COL1A1/ITGB2/CXCL2/CXCL3/TGFB3/LAMB2	2.29043398254229
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/396	56/9376	2.53679653679654	ITGB2/HSPA1A/CXCL2/CXCL3/IL18/CASP1	2.42213024836591
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/396	105/9376	2.02943722943723	VCAM1/GADD45B/CXCL2/CXCL3/TNFSF13B/BIRC3/LY96/TNFRSF1A/BCL2A1	2.22754400479907
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/396	73/9376	2.27037498270375	BST2/MAP1B/CXCR4/SAMHD1/MDFIC/MLLT3/CREBBP	2.28811008389147
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/396	73/9376	2.27037498270375	GADD45B/HGF/CDKN1A/PDGFA/PDGFRA/MAPK1/PDGFC	2.28811008389147
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/396	73/9376	2.27037498270375	GADD45B/HGF/FOXO3/EML4/CDKN1A/RARB/MAPK1	2.28811008389147
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	17/396	250/9376	1.6100202020202	CTSD/CTSS/CTSB/LAPTM5/CD68/CTSC/LGMN/ACP5/CTSZ/LIPA/IDS/CLCN7/PSAP/GNPTG/ASAH1/CTSO/HEXB	2.05290594652945
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/396	142/9376	1.83411580594679	TYROBP/TREM2/FCGR3A/ACP5/CSF1/NCF2/TGFBR1/SPI1/TNFRSF1A/NFATC2/MAPK1	2.10315194878134
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/396	196/9376	1.69119769119769	IL6ST/HLA-B/HLA-A/CXCL2/CXCL3/CDKN1A/HLA-F/VEGFA/TNFRSF1A/CALM2/NFATC2/MAPK1/FAS/CREBBP	2.05354411378742
Organismal Systems	Immune system	hsa04611	Platelet activation	10/396	126/9376	1.87910854577521	COL3A1/COL1A2/COL1A1/FCER1G/PTGIR/ADCY3/ARHGEF12/MAPK1/GUCY1A2/FERMT3	2.08618092854562
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/396	76/9376	2.18075491759702	GADD45B/CDKN1A/PDGFA/CALM2/PDGFRA/CAMK2D/MAPK1	2.17030188538277
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/396	144/9376	1.80864197530864	CXCL2/FOXO3/C1QA/CXCL3/C1QB/LY96/TNFRSF1A/C3AR1/C5AR1/FAS/LPIN2	2.05345264553569
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/396	93/9376	2.03671119800152	LYZ/ATP1B1/ADCY3/KCNMA1/CALM2/ATP1A2/ADRB3/GUCY1A2	2.10984305909761
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/396	163/9376	1.74307492098903	MMP9/CREB3L1/CDKN1A/TGFBR1/SMAD3/TGFB3/STAT6/NFATC2/MAPK1/ATF2/FAS/CREBBP	2.00965234150476
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/396	77/9376	2.1524334251607	GADD45B/CDKN1A/TGFBR1/SMAD3/VEGFA/TGFB3/MAPK1	2.13225012047641
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/396	77/9376	2.1524334251607	GADD45B/CDKN1A/TGFBR1/SMAD3/TGFB3/ABL1/MAPK1	2.13225012047641
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/396	78/9376	2.12483812483812	ITGB2/C1QA/C1QB/LY96/CALM2/CASP1/MAPK1	2.09477615181255
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/396	130/9376	1.82128982128982	COL3A1/COL1A2/COL1A1/MMP9/CREB3L1/TGFBR1/ADCY3/VEGFA/MAPK1/ATF2	1.98009594702583
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/396	63/9376	2.25493025493025	GADD45B/FZD2/CDKN1A/FZD1/WNT2/WNT5B	2.09865053252581
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/396	134/9376	1.76692296095281	PLA2G2A/CALD1/PTGIR/ADCY3/KCNMA1/ARHGEF12/PPP1R12B/CALM2/MAPK1/GUCY1A2	1.87765682529978
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/396	10/9376	4.73535353535354	SELENBP1/PAPSS2	2.48170238648089
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/396	120/9376	1.77575757575758	FOXO3/ARHGDIG/KIDINS220/IRAK3/ABL1/CALM2/CAMK2D/MAPK1/MATK	1.79597397164374
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/396	103/9376	1.83897224673924	SERPINE1/C1QA/C1QB/TGFBR1/TGFB3/TNFRSF1A/MAPK1/FAS	1.79784041844658
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/396	23/9376	3.08827404479578	ATP1B1/AQP1/ATP1A2	2.10557640038345
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/396	122/9376	1.74664679582712	ATP1B1/SLC16A10/DIO3/PLCE1/ATP1A2/MAPK1/MED13L/CREBBP/THRA	1.74311257634816
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/396	87/9376	1.90502728433763	GADD45B/CDKN1A/EREG/TGFBR1/SMAD3/TGFB3/MAPK1	1.78086861411319
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/396	70/9376	2.02943722943723	HGF/CDKN1A/VEGFA/TGFB3/MAPK1/CREBBP	1.81535860907103
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/396	105/9376	1.8039442039442	DES/TNNI3/SGCE/ADCY3/TGFB3/ITGA7/SNTB1/LMNA	1.73961174171628
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/396	89/9376	1.8622176824424	GJA1/ADCY3/PDGFA/PDGFRA/MAPK1/GUCY1A2/PDGFC	1.71620541740339
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/396	323/9376	1.39275103980986	TIMP3/VIM/MARCKS/CCND2/ZEB2/MMP9/CD44/THBS1/CDKN1A/TNC/MMP16/VEGFA/PDGFA/ABL1/PDGFRA/EFNA5/MAPK1/CREBBP/FOXP1	1.50840306888945
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/396	110/9376	1.72194674012856	SERPINE1/TIMP1/CDKN1A/VEGFA/IL6R/CAMK2D/MAPK1/CREBBP	1.59937541972279
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/396	75/9376	1.89414141414141	GSTT1/GSTM3/CDKN1A/BIRC3/MAPK1/FAS	1.63255222438814
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/396	42/9376	2.25493025493025	AOC1/INMT/TDO2/IL4I1	1.71161230303087
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/396	60/9376	1.97306397306397	VEGFA/SPHK1/MAPKAPK3/NFATC2/MAPK1	1.58780564465208
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/396	44/9376	2.1524334251607	CREB3L1/ARHGDIG/ADCY3/STX4	1.60897717071996
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/396	61/9376	1.94071866203014	FTL/ATP1B1/SLC40A1/CYBRD1/ATP1A2	1.54784800013074
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/396	154/9376	1.53745244654336	ATP1B1/CREB3L1/TNNI3/ADCY3/SCN7A/CALM2/ATP1A2/CAMK2D/MAPK1/ATF2	1.41215675723454
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/396	254/9376	1.39823431162014	HGF/CXCR4/HRC/FGFR2/ADCY3/PLCE1/VEGFA/PDGFA/SPHK1/CALM2/PDGFRA/NFATC2/CAMK2D/ADRB3/PDGFC	1.35115621439404
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/396	99/9376	1.6741148862361	DES/TNNI3/SGCE/TGFB3/ITGA7/SNTB1/LMNA	1.41593331240002
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	14/396	238/9376	1.39275103980986	IGF2/HGF/PLA2G2A/CSF1/FGFR2/PLCE1/VEGFA/PDGFA/ABL1/CALM2/PDGFRA/EFNA5/MAPK1/PDGFC	1.28876967354318
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/396	65/9376	1.82128982128982	CREB3L1/ADCY3/HSD3B2/ATF2/KCNK3	1.39524353301684
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/396	122/9376	1.55257492962411	CSH1/IGFBP3/CSH2/CREB3L1/ADCY3/MAPK1/ATF2/CREBBP	1.29003474545881
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/396	105/9376	1.57845117845118	FCER1G/ARHGEF12/CALM2/CASP1/LSP1/NFATC2/MAPK1	1.25167947863348
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/396	86/9376	1.65186751233263	DES/GJA1/SGCE/ITGA7/SNTB1/LMNA	1.27525128182165
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/396	205/9376	1.3859571322986	IL6ST/HLA-B/HLA-A/CCND2/CREB3L1/CDKN1A/HLA-F/RBPJ/MAPK1/ATF2/GSN/CREBBP	1.17328283631284
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/396	17/9376	2.78550207961973	INMT/PAPSS2	1.54726663378363
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/396	17/9376	2.78550207961973	NRP2/PCDH7	1.54726663378363
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/396	107/9376	1.5489474181063	CREB3L1/FBP1/GCK/CALM2/CAMK2D/ATF2/CREBBP	1.19922661203206
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/396	51/9376	1.85700138641315	PLD3/ENPP2/PLA2G2A/LPCAT2	1.28865675653918
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/396	90/9376	1.57845117845118	CREB3L1/FOXO3/ADCY3/SESN3/ATF2/SESN1	1.15789369222376
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/396	71/9376	1.66737800540617	CCND2/PRLR/FOXO3/GCK/MAPK1	1.18532634765108
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/396	19/9376	2.4922913343966	IDS/HEXB	1.36727906962975
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/396	93/9376	1.52753339850114	FN1/GADD45B/CDKN1A/RARB/BIRC3/LAMB2	1.07359955348739
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/396	154/9376	1.38370720188902	CDKN1A/RGS2/ADCY3/PPP1R12B/CALM2/NFATC2/CAMK2D/MAPK1/GUCY1A2	1.00819099704931
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/396	37/9376	1.91973791973792	VCAM1/IL18/FAS	1.17709043181335
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/396	37/9376	1.91973791973792	GADD45B/CDKN1A/MAPK1	1.17709043181335
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/396	75/9376	1.57845117845118	ATP1B1/CREB3L1/ADCY3/ATP1A2/ATF2	1.05615481303616
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/396	56/9376	1.69119769119769	CCND2/CDON/GAS1/DISP1	1.08939003658899
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/396	38/9376	1.86921850079745	ATP1B1/ATP1A2/MAPK1	1.12742818519578
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/396	76/9376	1.55768208399787	CD36/LPL/OLR1/CYP27A1/ANGPTL4	1.02505478512676
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/396	76/9376	1.55768208399787	ATP1B1/ADCY3/CALM2/ATP1A2/CAMK2D	1.02505478512676
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/396	21/9376	2.25493025493025	DSE/CHSY3	1.20893347727269
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/396	139/9376	1.36269166484994	CTSD/MMP9/CREB3L1/HSPA1A/ADCY3/CALM2/MAPK1/ATF2	0.904637457375984
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/396	59/9376	1.60520458825544	GADD45B/FOXO3/CDKN1A/MAPK1	0.979231178361946
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/396	227/9376	1.25163529568816	GSTT1/HGF/MT-ND2/FOXO3/GSTM3/NCF2/VEGFA/ABL1/AHR/NFE2L2/MAPK1/MT-ND5	0.805921487502731
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	13/396	250/9376	1.23119191919192	HLA-B/HLA-A/HSPA1A/CXCR4/FGFR2/RAB11FIP1/HLA-F/TGFBR1/SMAD3/EHD2/ARFGAP3/PDGFRA/ZFYVE16	0.778032045704168
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/396	63/9376	1.50328683662017	PLOD2/ASH1L/KMT2E/PRDM6	0.841658875890956
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/396	104/9376	1.36596736596737	PLD3/PLA2G2A/LPCAT2/SGMS2/DGKH/LPIN2	0.788074692546781
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/396	125/9376	1.32589898989899	CTSD/FCER1G/ASAH1/SPHK1/TNFRSF1A/SGMS2/MAPK1	0.770262479387923
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/396	168/9376	1.26839826839827	FTL/GLUL/CAPN2/BIRC3/TNFRSF1A/CASP1/STAT6/CAMK2D/FAS	0.737134534098297
NA	NA	hsa04517	IgSF CAM signaling	15/396	299/9376	1.18779770953684	SLIT3/NRP2/ITGB2/SLIT2/PMP22/LMO7/TRPC6/EPB41L2/CD84/NRP1/CASK/CXADR/ABL1/CADM1/MAPK1	0.693026402452197
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/396	149/9376	1.27123584841706	FCER1G/ADCY3/PDGFA/SPHK1/DGKH/PDGFRA/MAPK1/PDGFC	0.700817640562707
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	11/396	214/9376	1.21703011422638	HLA-B/HLA-A/BST2/CXCR4/SAMHD1/HLA-F/TNFRSF1A/CALM2/NFATC2/MAPK1/FAS	0.674414353507203
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/396	128/9376	1.29482323232323	ENPP1/PDE5A/ADCY3/PAPSS2/NME4/GUCY1A2/IMPDH1	0.705241467441122
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/396	86/9376	1.37655626027719	CDKN1A/EREG/ABL1/CAMK2D/MAPK1	0.736658668382019
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/396	193/9376	1.22677552729366	CXCL14/CXCL2/CXCR4/FOXO3/CXCL3/CCL18/ADCY3/CCL7/CXCL16/MAPK1	0.668463364653345
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/396	238/9376	1.19378660555131	IL6ST/RPS4Y1/C7/C1QA/C1QB/NRP1/TNFRSF1A/IL6R/CASP1/C3AR1/C5AR1/MAPK1	0.635889596866023
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/396	217/9376	1.20020481310804	GSTT1/CREB3L1/GSTM3/ADCY3/KLF4/VEGFA/AHR/PAQR8/ADRB3/MAPK1/ATF2	0.626578392723151
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/396	67/9376	1.41353836876225	CALM2/CAMK2D/MAPK1/CREBBP	0.713340298769209
NA	NA	hsa04081	Hormone signaling	11/396	219/9376	1.18924403855911	CSH1/IGF2/SLC40A1/PRLR/CSH2/SLC16A10/ADCY3/HAMP/SMAD5/ADRB3/THRA	0.595062689337094
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/396	89/9376	1.33015548745886	GABARAPL2/GLUL/SLC38A2/ADCY3/GABARAP	0.657159610270695
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/396	68/9376	1.39275103980986	RUNX1T1/SPI1/BCL2A1/MAPK1	0.68255660777766
NA	NA	hsa03272	Virion - Hepatitis viruses	3/396	48/9376	1.47979797979798	CLDN15/CD9/CD81	0.699809490410301
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/396	69/9376	1.37256624213146	CREB3L1/CALM2/CAMK2D/ATF2	0.652256254991568
NA	NA	hsa04519	Cadherin signaling	19/396	404/9376	1.11351135113511	VIM/DES/GJA1/CDH11/FZD2/LHFPL2/PCDH7/ENAH/FZD1/WNT2/WNT5B/PCDH10/YAP1/PRICKLE1/CDH6/PDGFRA/MAPK1/CREBBP/RYK	0.48975672267596
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/396	71/9376	1.33390240432494	FGFR2/GCK/PDGFRA/MAPK1	0.593042195254121
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/396	93/9376	1.27294449875095	LMO7/TGFBR1/SMAD3/MAPK1/CREBBP	0.555477800682274
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/396	93/9376	1.27294449875095	ADCY3/EGR1/CALM2/CAMK2D/MAPK1	0.555477800682274
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/396	226/9376	1.15240904621436	ATP1B1/FXYD1/CREB3L1/TNNI3/ADCY3/PLCE1/CALM2/ATP1A2/CAMK2D/MAPK1/CREBBP	0.487023010158882
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/396	94/9376	1.25940253599828	MMP9/CXCL2/CXCL3/CCL7/MAPK1	0.53077740295015
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/396	116/9376	1.22466039707419	VCAM1/MMP9/ITGB2/CXCR4/CLDN15/NCF2	0.511263850170619
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/396	52/9376	1.36596736596737	ADCY3/HSD17B2/HSD3B2	0.555696885159005
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/396	97/9376	1.22045194210143	ADCY3/CALM2/CAMK2D/MAPK1/GUCY1A2	0.458294105812948
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/396	32/9376	1.47979797979798	GABARAPL2/GABARAP	0.570902641093534
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/396	32/9376	1.47979797979798	BIRC3/TNFRSF1A	0.570902641093534
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/396	98/9376	1.20799835085549	MARCKS/FCGR3A/SPHK1/MAPK1/GSN	0.434651125155276
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/396	99/9376	1.1957963473115	PDGFA/DGKH/PDGFRA/MAPK1/PDGFC	0.411257155516215
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/396	102/9376	1.16062586650822	ATP1B1/PLA2G2A/ADCY3/KCNMA1/ATP1A2	0.342513021104675
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/396	148/9376	1.11984711984712	GADD45B/FZD2/CDKN1A/FZD1/WNT2/WNT5B/MAPK1	0.308602705502842
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/396	36/9376	1.31537598204265	ENPP1/GCK	0.398108537287852
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/396	174/9376	1.0885870196215	MAN1A1/FBXO2/HSPA1A/BAG2/CAPN2/MBTPS1/NFE2L2/HERPUD1	0.247684405207305
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/396	82/9376	1.1549642769155	GSTT1/GSTM3/NME4/IMPDH1	0.295959475557692
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/396	37/9376	1.27982527982528	GLUL/IL4I1	0.358123387535971
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/396	83/9376	1.1410490446635	SAMHD1/IL18/CASP1/IFI16	0.271035569465962
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/396	15/9376	1.57845117845118	HEXB	0.470810651785531
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/396	38/9376	1.2461456671983	GCK/HEXB	0.319265596174708
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/396	62/9376	1.14565004887586	HSPA1A/FOXO3/ADCY3	0.241620303483213
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/396	62/9376	1.14565004887586	RBPJ/MAML2/CREBBP	0.241620303483213
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/396	16/9376	1.47979797979798	IL4I1	0.403343947894681
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/396	16/9376	1.47979797979798	HEXB	0.403343947894681
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/396	63/9376	1.12746512746513	LTA4H/PLA2G2A/HPGD	0.21316304757353
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/396	158/9376	1.0489707198568	CCND2/GADD45B/CDKN1A/SMAD3/TGFB3/ABL1/CREBBP	0.130359216781677
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/396	158/9376	1.0489707198568	FZD2/FZD1/WNT2/WNT5B/TNFRSF1A/MAPK1/LPIN2	0.130359216781677
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/396	87/9376	1.0885870196215	ATP1B1/TNNI3/HRC/ATP1A2	0.174317222908064
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/396	17/9376	1.39275103980986	CYP27A1	0.340347169694169
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/396	17/9376	1.39275103980986	GLUL	0.340347169694169
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/396	65/9376	1.09277389277389	LPL/DGKH/LPIN2	0.157608399093861
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/396	138/9376	1.02942468159859	PRKAR2B/FBP1/GCK/CALM2/PPP1R3C/MAPK1	0.0731235721926732
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/396	138/9376	1.02942468159859	FN1/ARHGEF12/IL18/CASP1/NFATC2/MAPK1	0.0731235721926732
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/396	90/9376	1.05230078563412	ATP1B1/ADCY3/AQP1/ATP1A2	0.104691203060976
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/396	66/9376	1.07621671258035	HSD17B2/HSD3B2/HSD17B11	0.130479535728077
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/396	42/9376	1.12746512746513	FTL/SLC40A1	0.173851000499494
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/396	18/9376	1.31537598204265	HEXB	0.281234380078725
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/396	43/9376	1.10124500822175	CD36/PLA2G2A	0.13973084252242
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/396	44/9376	1.07621671258035	MAN1A1/HEXB	0.10641044236634
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/396	69/9376	1.02942468159859	FCER1G/ALOX5AP/MAPK1	0.0515141482331258
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/396	70/9376	1.01471861471861	GSTT1/GSTM3/SULT1A1	0.0259555057646824
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	16/396	388/9376	0.976361553681141	APOE/LPL/MT-ND2/FZD2/CSF1/FZD1/WNT2/WNT5B/CAPN2/SLC39A13/TNFRSF1A/CALM2/DKK2/MAPK1/FAS/MT-ND5	-0.0998615544638705
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/396	20/9376	1.18383838383838	LIPA	0.172822843921742
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/396	21/9376	1.12746512746513	ENPP1	0.122793166530189
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/396	47/9376	1.00752202879862	GCK/MAPK1	0.010855790088973
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	10/396	248/9376	0.954708374063213	S100A10/PODXL/BIRC3/AHNAK/LY96/IL18/TNFRSF1A/PFN2/CASP1/MAPK1	-0.151792739616296
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/396	99/9376	0.956637077849199	MMP9/CDKN1A/ADCY3/MAPK1	-0.0910809229256861
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/396	48/9376	0.986531986531986	ATP1B1/ATP1A2	-0.0196437751694119
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/396	22/9376	1.07621671258035	AOC1	0.0751550093338946
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	8/396	200/9376	0.947070707070707	CLDN15/ARHGEF12/IL18/TNFRSF1A/ABL1/CASP1/MAPK1/FAS	-0.158883738673334
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	11/396	275/9376	0.947070707070707	C7/CREB3L1/MT-ND2/HSPA1A/C1QA/C1QB/NCF2/EGR1/MAPK1/ATF2/MT-ND5	-0.187073790032203
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/396	49/9376	0.966398680684395	CREB3L1/ATF2	-0.0495197500859493
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/396	23/9376	1.02942468159859	GLUL	0.0296684792483052
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/396	23/9376	1.02942468159859	GGPS1	0.0296684792483052
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/396	23/9376	1.02942468159859	REN	0.0296684792483052
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	10/396	253/9376	0.935840619635086	CD44/FOXO3/CAST/PLCE1/CAPN2/IL18/TNFRSF1A/PFN2/CASP1/MAPK1	-0.217243427917906
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/396	24/9376	0.986531986531986	EXT1	-0.0138724119387295
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/396	156/9376	0.910644910644911	CLDN15/CDKN1A/CD81/TNFRSF1A/MAPK1/FAS	-0.23632583167302
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/396	53/9376	0.89346293119878	ATP1B1/ATP1A2	-0.163326215591643
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/396	54/9376	0.876917321361766	SDS/IL4I1	-0.190473399343155
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/396	26/9376	0.910644910644911	PLA2G2A	-0.0958065551515146
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/396	26/9376	0.910644910644911	GCK	-0.0958065551515146
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/396	109/9376	0.86887220832175	CD36/CREB3L1/TNFRSF1A/PPP1R3C	-0.289156845074369
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/396	85/9376	0.835650623885918	ENPP1/NME4/IMPDH1	-0.319625452184535
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/396	29/9376	0.816440264716127	YAP1	-0.207890844356051
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/396	29/9376	0.816440264716127	CALM2	-0.207890844356051
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/396	59/9376	0.802602294127718	ENPP1/NME4	-0.31939280018425
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/396	59/9376	0.802602294127718	GSTT1/GSTM3	-0.31939280018425
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/396	59/9376	0.802602294127718	ADCY3/ADRB3	-0.31939280018425
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/396	115/9376	0.823539745278876	CREB3L1/ADCY3/CAMK2D/MAPK1	-0.399817632059688
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/396	195/9376	0.84993524993525	FCGR3A/ITGB2/NCF2/FPR3/CASP1/C5AR1/MAPK1	-0.444678430414077
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/396	169/9376	0.840595302133764	CTSD/CTSB/GABARAPL2/GABARAP/DAPK1/MAPK1	-0.439117211632374
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/396	30/9376	0.789225589225589	PLA2G2A	-0.242806710768968
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/396	60/9376	0.789225589225589	MAPK1/GUCY1A2	-0.343932987388305
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/396	116/9376	0.816440264716127	GLUL/SLC38A2/ADCY3/MAPK1	-0.417730308589017
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/396	117/9376	0.809462142795476	SMARCA1/RSF1/BAZ2B/SMARCC2	-0.435499066544747
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/396	31/9376	0.76376669925057	FBP1	-0.276647898178732
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/396	31/9376	0.76376669925057	GLUL	-0.276647898178732
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/396	90/9376	0.789225589225589	EML4/NFATC2/MAPK1	-0.421910041520415
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/396	91/9376	0.780552780552781	CD81/NFATC2/MAPK1	-0.441727957695392
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/396	32/9376	0.73989898989899	GCK	-0.309489326487547
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/396	33/9376	0.717477808386899	STX4	-0.341398355568503
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/396	122/9376	0.776287464812055	CD36/CREB3L1/FOXO3/FBP1	-0.522276578098549
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/396	65/9376	0.728515928515929	SPP1/MAPK1	-0.461209167867629
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/396	35/9376	0.676479076479077	FBP1	-0.402656554146618
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/396	67/9376	0.706769184381125	FBP1/GCK	-0.505813664274922
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/396	98/9376	0.724799010513296	PLCE1/CALM2/DGKH	-0.575083500577099
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/396	99/9376	0.717477808386899	ADCY3/CALM2/CAMK2D	-0.593419001367587
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/396	37/9376	0.63991263991264	IL4I1	-0.46084365674141
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/396	37/9376	0.63991263991264	GCK	-0.46084365674141
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/396	70/9376	0.676479076479077	CD36/TNFRSF1A	-0.570512195337432
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/396	38/9376	0.623072833599149	ENPP1	-0.488896992846368
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/396	71/9376	0.66695120216247	CXCL2/CXCL3	-0.591526109539794
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/396	133/9376	0.712083238399028	CREB3L1/CALM2/CAMK2D/ATF2	-0.70223319608516
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/396	73/9376	0.648678566486786	GSTT1/GSTM3	-0.632775460516331
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/396	105/9376	0.676479076479077	GABARAPL2/FOXO3/GABARAP	-0.700049573697719
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/396	41/9376	0.577482138457748	SDS	-0.569344203049769
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/396	75/9376	0.631380471380471	GLUL/SDS	-0.673037421019782
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/396	138/9376	0.68628312106573	ADCY3/CALM2/CAMK2D/MAPK1	-0.779620971188551
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/396	109/9376	0.651654156241312	SPP1/LY96/MAPK1	-0.768155887374242
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/396	78/9376	0.607096607096607	XRN1/CNOT6L	-0.73170053472246
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/396	79/9376	0.599411839918169	GSTT1/GSTM3	-0.750819082593597
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/396	46/9376	0.514712340799297	FTL	-0.692839124452027
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/396	83/9376	0.570524522331751	CBX6/CREBBP	-0.825267061816549
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/396	235/9376	0.705265420159037	CREB3L1/MT-ND2/ADCY3/SMARCC2/ADRB3/ATF2/MT-ND5	-0.960866897899693
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/396	116/9376	0.612330198537095	SDS/FBP1/GCK	-0.882227387968835
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/396	48/9376	0.493265993265993	IL4I1	-0.739097040749125
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/396	49/9376	0.483199340342197	GXYLT2	-0.761631984450767
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/396	149/9376	0.635617924208528	MT-ND2/ADCY3/MAPK1/MT-ND5	-0.941488332423032
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/396	50/9376	0.473535353535354	AOC1	-0.783793345383643
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/396	51/9376	0.464250346603288	ADCY3	-0.805596608837183
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/396	56/9376	0.422799422799423	MAN1A1	-0.909720281076398
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	15/396	480/9376	0.73989898989899	MT-ND2/FZD2/CSF1/FZD1/WNT2/WNT5B/CCS/CAPN2/TNFRSF1A/CALM2/DKK2/CAMK2D/MAPK1/FAS/MT-ND5	-1.22845805739218
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/396	370/9376	0.703903903903904	CSH1/NR3C1/PRLR/CSH2/TAC3/FPR3/PTGIR/C3AR1/C5AR1/ADRB3/THRA	-1.22028882730076
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/396	136/9376	0.522281639928699	CCND2/HSPA1A/FAS	-1.17842097543619
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/396	268/9376	0.618423036333484	DUSP1/MT-ND2/SLC39A13/CALM2/NFE2L2/CAMK2D/MT-ND5	-1.33086222023964
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/396	68/9376	0.348187759952466	CYP2W1	-1.13277548976111
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/396	110/9376	0.43048668503214	ADCY3/MAPK1	-1.26167977017562
NA	NA	hsa04382	Cornified envelope formation	5/396	217/9376	0.545547642321836	S100A10/DST/CLDN15/UGCG/COL17A1	-1.4222936173346
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/396	115/9376	0.411769872639438	DUSP1/MAPK1	-1.33279177795108
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/396	191/9376	0.495848537733354	CREB3L1/CALM2/MAPK1/ATF2	-1.47819999784306
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/396	157/9376	0.452422312294924	TNFRSF1A/IL6R/FAS	-1.45294349549678
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/396	78/9376	0.303548303548304	PLCE1	-1.29699587202946
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/396	78/9376	0.303548303548304	FN1	-1.29699587202946
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/396	194/9376	0.488180776840571	TNNT1/TNNI3/TNNT3/KIF1B	-1.51266889600507
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/396	122/9376	0.388143732406028	NFATC2/MAPK1	-1.42843223987723
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/396	91/9376	0.26018426018426	ADCY3	-1.48918403542731
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/396	138/9376	0.343141560532865	MT-ND2/MT-ND5	-1.63236551456978
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/396	142/9376	0.333475601081235	FBXO2/BIRC3	-1.68058449258751
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/396	154/9376	0.307490489308671	TDO2/NME4	-1.81956932424729
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/396	108/9376	0.219229330340441	NUP214	-1.71371034467505
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	7/396	368/9376	0.450373298199385	MT-ND2/CCS/TNFRSF1A/NUP214/PFN2/CASP1/MT-ND5	-2.25877309849527
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/396	183/9376	0.258762488270685	RPP25/XRN1	-2.12642156077523
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/396	144/9376	0.164421997755331	RBPJ	-2.12185356641404
NA	NA	hsa04082	Neuroactive ligand signaling	2/396	199/9376	0.237957464088117	TAC3/ADCY3	-2.28165747803037
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	4/396	308/9376	0.307490489308671	CREB3L1/MT-ND2/CREBBP/MT-ND5	-2.59501819695373
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/396	170/9376	0.139275103980986	CLDN15	-2.37820015525851
Genetic Information Processing	Translation	hsa03010	Ribosome	1/396	222/9376	0.106652106652107	RPS4Y1	-2.82869884819818
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/396	243/9376	0.0974352579290851	HSPA1A	-2.99343501887963
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/396	449/9376	0.210928887989022	RGS2/ADCY3/CALM2/CAMK2D	-3.59816943469208