ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 52/728 168/18639 0.30952380952381 7.92474489795918 1.31799379152296e-32 1.26527403986204e-29 GO:0005539 glycosaminoglycan binding 40/728 242/18639 0.165289256198347 4.23190445917719 8.65382371113013e-15 4.15383538134246e-12 GO:0005518 collagen binding 22/728 72/18639 0.305555555555556 7.82314560439561 2.1632762295151e-14 5.95681379957239e-12 GO:0008201 heparin binding 33/728 172/18639 0.191860465116279 4.91220770508561 2.48200574982183e-14 5.95681379957239e-12 GO:0019838 growth factor binding 29/728 136/18639 0.213235294117647 5.4594679217841 5.40200750798881e-14 1.03718544153385e-11 GO:0005178 integrin binding 31/728 161/18639 0.192546583850932 4.92977441812846 1.3763276832421e-13 2.20212429318735e-11 GO:1901681 sulfur compound binding 38/728 275/18639 0.138181818181818 3.53787212787213 1.2205144977124e-11 1.67384845400558e-09 GO:0030020 extracellular matrix structural constituent conferring tensile strength 15/728 44/18639 0.340909090909091 8.72830294705295 5.21075300855082e-11 6.25290361026098e-09 GO:0023026 MHC class II protein complex binding 12/728 27/18639 0.444444444444444 11.3791208791209 1.16830038187201e-10 1.24618707399681e-08 GO:0050840 extracellular matrix binding 16/728 67/18639 0.238805970149254 6.1141545022142 4.35359875132579e-09 4.17945480127276e-07 GO:0046332 SMAD binding 17/728 79/18639 0.215189873417722 5.50951105856169 7.88026457211136e-09 6.06106438832144e-07 GO:0023023 MHC protein complex binding 12/728 37/18639 0.324324324324324 8.3036828036828 8.68610313325815e-09 6.06106438832144e-07 GO:0043394 proteoglycan binding 12/728 37/18639 0.324324324324324 8.3036828036828 8.68610313325815e-09 6.06106438832144e-07 GO:0019955 cytokine binding 23/728 144/18639 0.159722222222222 4.08937156593407 8.83905223296876e-09 6.06106438832144e-07 GO:0048407 platelet-derived growth factor binding 7/728 11/18639 0.636363636363636 16.2928321678322 3.87799182388791e-08 2.48191476728826e-06 GO:0042605 peptide antigen binding 12/728 45/18639 0.266666666666667 6.82747252747253 1.01161303232316e-07 6.06967819393895e-06 GO:0032395 MHC class II receptor activity 6/728 10/18639 0.6 15.3618131868132 6.38607341620841e-07 3.60625322327063e-05 GO:0030021 extracellular matrix structural constituent conferring compression resistance 8/728 22/18639 0.363636363636364 9.31018981018981 1.02432907593925e-06 5.46308840500932e-05 GO:0061134 peptidase regulator activity 24/728 226/18639 0.106194690265487 2.71890498881649 9.13092357605757e-06 0.000461351928053435 GO:0001217 DNA-binding transcription repressor activity 27/728 278/18639 0.0971223021582734 2.48662443671437 1.34970263678156e-05 0.000647857265655149 GO:0019841 retinol binding 6/728 16/18639 0.375 9.60113324175824 1.99031151159636e-05 0.000868499568696592 GO:0070411 I-SMAD binding 6/728 16/18639 0.375 9.60113324175824 1.99031151159636e-05 0.000868499568696592 GO:0050431 transforming growth factor beta binding 7/728 24/18639 0.291666666666667 7.46754807692308 2.60534309597201e-05 0.00108744755310136 GO:0140375 immune receptor activity 18/728 156/18639 0.115384615384615 2.95419484361792 3.94192719134923e-05 0.00157677087653969 GO:0042277 peptide binding 24/728 249/18639 0.0963855421686747 2.46776115450814 4.53438161046291e-05 0.00174120253841776 GO:0016918 retinal binding 6/728 19/18639 0.315789473684211 8.08516483516484 6.09835152287831e-05 0.00225169902383199 GO:0005126 cytokine receptor binding 25/728 275/18639 0.0909090909090909 2.32754745254745 8.26738146360128e-05 0.00293951340928046 GO:0098531 ligand-modulated transcription factor activity 10/728 60/18639 0.166666666666667 4.26717032967033 9.98719880650923e-05 0.00342418244794602 GO:0061135 endopeptidase regulator activity 19/728 184/18639 0.103260869565217 2.64379031294792 0.000111231608106852 0.00360459443876138 GO:0030414 peptidase inhibitor activity 18/728 169/18639 0.106508875739645 2.72694908641654 0.000112643576211293 0.00360459443876138 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 24/728 268/18639 0.0895522388059701 2.29280793833033 0.000143513924577233 0.00444430218045624 GO:0071813 lipoprotein particle binding 7/728 32/18639 0.21875 5.60066105769231 0.000192945200621949 0.00561295129082034 GO:0071814 protein-lipid complex binding 7/728 32/18639 0.21875 5.60066105769231 0.000192945200621949 0.00561295129082034 GO:0008083 growth factor activity 17/728 162/18639 0.104938271604938 2.68673687423687 0.000207048248246762 0.00584606818579092 GO:0019199 transmembrane receptor protein kinase activity 11/728 78/18639 0.141025641025641 3.61068258664413 0.000214353756509022 0.00587941732139033 GO:0004175 endopeptidase activity 31/728 405/18639 0.0765432098765432 1.95973748473748 0.000297385458814835 0.00793027890172893 GO:0001540 amyloid-beta binding 11/728 83/18639 0.132530120481928 3.3931715874487 0.000372890988119019 0.00947191381572416 GO:0030169 low-density lipoprotein particle binding 5/728 17/18639 0.294117647058824 7.53030058177117 0.000374929921872414 0.00947191381572416 GO:0005160 transforming growth factor beta receptor binding 6/728 26/18639 0.230769230769231 5.90838968723584 0.000409626134085065 0.00983102721804156 GO:0030247 polysaccharide binding 6/728 26/18639 0.230769230769231 5.90838968723584 0.000409626134085065 0.00983102721804156 GO:0004879 nuclear receptor activity 9/728 59/18639 0.152542372881356 3.90554572546098 0.000439422182505176 0.0102889096391456 GO:0001216 DNA-binding transcription activator activity 35/728 491/18639 0.0712830957230143 1.82506266645778 0.000474582762614725 0.0108476060026223 GO:0005516 calmodulin binding 19/728 207/18639 0.0917874396135266 2.35003583373149 0.000505093663291047 0.0111146271438459 GO:0005044 scavenger receptor activity 6/728 27/18639 0.222222222222222 5.68956043956044 0.000509420410759605 0.0111146271438459 GO:0004866 endopeptidase inhibitor activity 16/728 161/18639 0.0993788819875776 2.5443996996792 0.000578924046382982 0.0123503796561703 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 27/728 349/18639 0.0773638968481375 1.98074955130829 0.000606353445953839 0.0124873732757459 GO:0048185 activin binding 4/728 11/18639 0.363636363636364 9.31018981018981 0.000611360983291728 0.0124873732757459 GO:0046875 ephrin receptor binding 6/728 28/18639 0.214285714285714 5.48636185243328 0.00062714414095836 0.0125428828191672 GO:0005520 insulin-like growth factor binding 5/728 19/18639 0.263157894736842 6.73763736263736 0.000660237223677211 0.0129352598924515 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 34/728 484/18639 0.0702479338842975 1.7985593951503 0.00073479258369639 0.0141080176069707 GO:0008013 beta-catenin binding 12/728 106/18639 0.113207547169811 2.89845531826664 0.00088019934119682 0.0164426219315174 GO:0005125 cytokine activity 20/728 234/18639 0.0854700854700855 2.18829247675402 0.00089901863173056 0.0164426219315174 GO:0038024 cargo receptor activity 9/728 65/18639 0.138461538461538 3.5450338123415 0.000908053795830599 0.0164426219315174 GO:0001968 fibronectin binding 6/728 30/18639 0.2 5.1206043956044 0.000924897483647854 0.0164426219315174 GO:0017147 Wnt-protein binding 6/728 31/18639 0.193548387096774 4.95542360864942 0.00110944510478176 0.0193648600107362 GO:0030165 PDZ domain binding 10/728 83/18639 0.120481927710843 3.08470144313518 0.00144107336539111 0.0247041148352762 GO:0140311 protein sequestering activity 6/728 33/18639 0.181818181818182 4.6550949050949 0.00156188520544221 0.0263054350390266 GO:0140297 DNA-binding transcription factor binding 33/728 488/18639 0.0676229508196721 1.73135189605477 0.00164104815543344 0.0265744608575619 GO:0005161 platelet-derived growth factor receptor binding 4/728 14/18639 0.285714285714286 7.31514913657771 0.00168858553365758 0.0265744608575619 GO:0008191 metalloendopeptidase inhibitor activity 4/728 14/18639 0.285714285714286 7.31514913657771 0.00168858553365758 0.0265744608575619 GO:0042813 Wnt receptor activity 4/728 14/18639 0.285714285714286 7.31514913657771 0.00168858553365758 0.0265744608575619 GO:0004857 enzyme inhibitor activity 29/728 416/18639 0.0697115384615385 1.78482605135249 0.00196181558195148 0.0303764993334423 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 5/728 24/18639 0.208333333333333 5.33396291208791 0.00205289915291195 0.0312822728062773 GO:0004714 transmembrane receptor protein tyrosine kinase activity 8/728 60/18639 0.133333333333333 3.41373626373626 0.00221437857221969 0.0326871047899025 GO:0005041 low-density lipoprotein particle receptor activity 4/728 15/18639 0.266666666666667 6.82747252747253 0.00223200369734149 0.0326871047899025 GO:0004197 cysteine-type endopeptidase activity 10/728 88/18639 0.113636363636364 2.90943431568432 0.0022472384543058 0.0326871047899025 GO:0015026 coreceptor activity 8/728 61/18639 0.131147540983607 3.35777337416682 0.00246321966601556 0.0352938937220139 GO:0003779 actin binding 30/728 443/18639 0.0677200902934537 1.73383896013693 0.00255887679046898 0.0361253193948563 GO:0050681 nuclear androgen receptor binding 5/728 26/18639 0.192307692307692 4.92365807269653 0.00297874213926241 0.0414433688940857 GO:0005109 frizzled binding 6/728 38/18639 0.157894736842105 4.04258241758242 0.00330024765879964 0.0440033021173285 GO:0005501 retinoid binding 6/728 38/18639 0.157894736842105 4.04258241758242 0.00330024765879964 0.0440033021173285 GO:0019840 isoprenoid binding 6/728 38/18639 0.157894736842105 4.04258241758242 0.00330024765879964 0.0440033021173285 GO:0004713 protein tyrosine kinase activity 13/728 140/18639 0.0928571428571429 2.37742346938776 0.00334665899947711 0.0440108580753154 GO:0005021 vascular endothelial growth factor receptor activity 7/728 51/18639 0.137254901960784 3.51414027149321 0.00349412036615401 0.0453291290744304 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 4/728 17/18639 0.235294117647059 6.02424046541694 0.00365715921209751 0.0468116379148481 GO:0045499 chemorepellent activity 5/728 28/18639 0.178571428571429 4.57196821036107 0.00417317064085102 0.0527137344107498 GO:0030228 lipoprotein particle receptor activity 4/728 18/18639 0.222222222222222 5.68956043956044 0.0045584793071686 0.0568329887646995 GO:0140313 molecular sequestering activity 7/728 55/18639 0.127272727272727 3.25856643356643 0.00535633626838901 0.0659241386878647 GO:0048487 beta-tubulin binding 6/728 42/18639 0.142857142857143 3.65757456828885 0.00549748394603131 0.0668048682049374 GO:0043395 heparan sulfate proteoglycan binding 4/728 19/18639 0.210526315789474 5.39010989010989 0.00559801052943298 0.0671761263531958 GO:0033612 receptor serine/threonine kinase binding 5/728 30/18639 0.166666666666667 4.26717032967033 0.00567489289399495 0.067257989854755 GO:0001223 transcription coactivator binding 6/728 44/18639 0.136363636363636 3.49132117882118 0.00692766868915571 0.0811044139218229 GO:0002020 protease binding 12/728 136/18639 0.0882352941176471 2.25909017453135 0.00706177917726235 0.0816784097611067 GO:0005114 type II transforming growth factor beta receptor binding 3/728 11/18639 0.272727272727273 6.98264235764236 0.00773987604249756 0.0844350113727007 GO:0019864 IgG binding 3/728 11/18639 0.272727272727273 6.98264235764236 0.00773987604249756 0.0844350113727007 GO:0034713 type I transforming growth factor beta receptor binding 3/728 11/18639 0.272727272727273 6.98264235764236 0.00773987604249756 0.0844350113727007 GO:0042608 T cell receptor binding 3/728 11/18639 0.272727272727273 6.98264235764236 0.00773987604249756 0.0844350113727007 GO:0097493 structural molecule activity conferring elasticity 3/728 11/18639 0.272727272727273 6.98264235764236 0.00773987604249756 0.0844350113727007 GO:0033218 amide binding 18/728 247/18639 0.0728744939271255 1.86580726965342 0.00848841204320526 0.0905775481484184 GO:0030296 protein tyrosine kinase activator activity 5/728 33/18639 0.151515151515152 3.87924575424575 0.00858599675156883 0.0905775481484184 GO:0140416 transcription regulator inhibitor activity 5/728 33/18639 0.151515151515152 3.87924575424575 0.00858599675156883 0.0905775481484184 GO:0005504 fatty acid binding 6/728 47/18639 0.127659574468085 3.26847089081132 0.00955156407329254 0.0996684946778352 GO:0043178 alcohol binding 9/728 92/18639 0.0978260869565217 2.50464345437172 0.00975639995706477 0.100235673513688 GO:0004875 complement receptor activity 3/728 12/18639 0.25 6.40075549450549 0.0100235673513688 0.100235673513688 GO:0035259 nuclear glucocorticoid receptor binding 3/728 12/18639 0.25 6.40075549450549 0.0100235673513688 0.100235673513688 GO:0035497 cAMP response element binding 3/728 12/18639 0.25 6.40075549450549 0.0100235673513688 0.100235673513688 GO:0004222 metalloendopeptidase activity 10/728 110/18639 0.0909090909090909 2.32754745254745 0.0109109806736973 0.10798496336855 GO:0033293 monocarboxylic acid binding 8/728 79/18639 0.10126582278481 2.59271108638197 0.0118569585277335 0.116149797822695 GO:0017154 semaphorin receptor activity 3/728 13/18639 0.230769230769231 5.90838968723584 0.0126573339360951 0.119127848810307 GO:0031994 insulin-like growth factor I binding 3/728 13/18639 0.230769230769231 5.90838968723584 0.0126573339360951 0.119127848810307 GO:0070123 transforming growth factor beta receptor activity, type III 3/728 13/18639 0.230769230769231 5.90838968723584 0.0126573339360951 0.119127848810307 GO:0070700 BMP receptor binding 3/728 13/18639 0.230769230769231 5.90838968723584 0.0126573339360951 0.119127848810307 GO:0035035 histone acetyltransferase binding 4/728 24/18639 0.166666666666667 4.26717032967033 0.0131545924583665 0.122605910291572 GO:0001221 transcription coregulator binding 10/728 115/18639 0.0869565217391304 2.2263497372193 0.01460473069263 0.1348128987012 GO:0003707 nuclear steroid receptor activity 4/728 25/18639 0.16 4.09648351648352 0.0151869564753819 0.138852173489206 GO:0031625 ubiquitin protein ligase binding 20/728 302/18639 0.0662251655629139 1.69556436940543 0.0154171314635771 0.139626850990886 GO:0005003 ephrin receptor activity 6/728 53/18639 0.113207547169811 2.89845531826664 0.0167920742563777 0.149262882278913 GO:0005005 transmembrane-ephrin receptor activity 6/728 53/18639 0.113207547169811 2.89845531826664 0.0167920742563777 0.149262882278913 GO:0070412 R-SMAD binding 4/728 26/18639 0.153846153846154 3.93892645815723 0.0174066318092218 0.153306115017 GO:0016922 nuclear receptor binding 11/728 137/18639 0.0802919708029197 2.05571709312585 0.0185823967931515 0.162173644740231 GO:0005523 tropomyosin binding 3/728 15/18639 0.2 5.1206043956044 0.019003012542069 0.164350378742219 GO:0003823 antigen binding 13/728 174/18639 0.0747126436781609 1.91286945812808 0.0192058139143609 0.164621262123093 GO:0005543 phospholipid binding 29/728 497/18639 0.0583501006036217 1.49393890817432 0.0209804800469184 0.178241246416298 GO:0051019 mitogen-activated protein kinase binding 4/728 28/18639 0.142857142857143 3.65757456828885 0.0224257379837608 0.188048970252152 GO:0005024 transforming growth factor beta receptor activity 3/728 16/18639 0.1875 4.80056662087912 0.0227225839054683 0.188048970252152 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/728 16/18639 0.1875 4.80056662087912 0.0227225839054683 0.188048970252152 GO:0016504 peptidase activator activity 6/728 57/18639 0.105263157894737 2.69505494505495 0.0233109017881083 0.191268937748581 GO:0003713 transcription coactivator activity 17/728 256/18639 0.06640625 1.70020067822802 0.0236416383476536 0.192338752658877 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/728 29/18639 0.137931034482759 3.53145130731338 0.0252325397423992 0.20355662313196 GO:0008429 phosphatidylethanolamine binding 3/728 17/18639 0.176470588235294 4.5181803490627 0.0268080320540478 0.21269182456104 GO:0038191 neuropilin binding 3/728 17/18639 0.176470588235294 4.5181803490627 0.0268080320540478 0.21269182456104 GO:0044389 ubiquitin-like protein ligase binding 20/728 322/18639 0.062111801242236 1.5902498122995 0.0283180204183481 0.222830324603395 GO:0008009 chemokine activity 5/728 45/18639 0.111111111111111 2.84478021978022 0.0302054765560773 0.233848850756727 GO:0141110 transporter inhibitor activity 5/728 45/18639 0.111111111111111 2.84478021978022 0.0302054765560773 0.233848850756727 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/728 18/18639 0.166666666666667 4.26717032967033 0.0312579426034236 0.240060999194293 GO:0031406 carboxylic acid binding 13/728 187/18639 0.0695187165775401 1.77988922841864 0.0321974043894515 0.245313557252964 GO:0003712 transcription coregulator activity 28/728 495/18639 0.0565656565656566 1.44825174825175 0.0325532763772822 0.246072010410952 GO:0043177 organic acid binding 13/728 189/18639 0.0687830687830688 1.76105442176871 0.0346524453272945 0.259523691740084 GO:0043425 bHLH transcription factor binding 4/728 32/18639 0.125 3.20037774725275 0.0348734960775738 0.259523691740084 GO:0005229 intracellularly calcium-gated chloride channel activity 3/728 19/18639 0.157894736842105 4.04258241758242 0.0360691798672969 0.26432376085958 GO:0141147 intracellularly calcium-gated channel activity 3/728 19/18639 0.157894736842105 4.04258241758242 0.0360691798672969 0.26432376085958 GO:0051087 protein-folding chaperone binding 10/728 134/18639 0.0746268656716418 1.91067328194194 0.0373447780105648 0.271526211195017 GO:0019956 chemokine binding 4/728 33/18639 0.121212121212121 3.1033966033966 0.0384993580535745 0.271526211195017 GO:0044325 transmembrane transporter binding 10/728 136/18639 0.0735294117647059 1.88257514544279 0.0406760124097276 0.271526211195017 GO:0001972 retinoic acid binding 3/728 20/18639 0.15 3.8404532967033 0.0412370724745605 0.271526211195017 GO:0016505 peptidase activator activity involved in apoptotic process 3/728 20/18639 0.15 3.8404532967033 0.0412370724745605 0.271526211195017 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/728 20/18639 0.15 3.8404532967033 0.0412370724745605 0.271526211195017 GO:0005004 GPI-linked ephrin receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0005008 hepatocyte growth factor receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0005009 insulin receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0005011 macrophage colony-stimulating factor receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0005018 platelet-derived growth factor alpha-receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0005020 stem cell factor receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0008288 boss receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0036332 placental growth factor receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0038062 protein tyrosine kinase collagen receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0060175 brain-derived neurotrophic factor receptor activity 5/728 49/18639 0.102040816326531 2.61255326306347 0.041577451089237 0.271526211195017 GO:0030332 cyclin binding 4/728 34/18639 0.117647058823529 3.01212023270847 0.0423326070184422 0.274589883362869 GO:0005006 epidermal growth factor receptor activity 5/728 50/18639 0.1 2.5603021978022 0.0447731528795974 0.282777807660615 GO:0005007 fibroblast growth factor receptor activity 5/728 50/18639 0.1 2.5603021978022 0.0447731528795974 0.282777807660615 GO:0005017 platelet-derived growth factor receptor activity 5/728 50/18639 0.1 2.5603021978022 0.0447731528795974 0.282777807660615 GO:0005019 platelet-derived growth factor beta-receptor activity 5/728 50/18639 0.1 2.5603021978022 0.0447731528795974 0.282777807660615 GO:0070851 growth factor receptor binding 10/728 139/18639 0.0719424460431655 1.84194402719583 0.0460456634058854 0.288913966468301 GO:0010485 histone H4 acetyltransferase activity 4/728 35/18639 0.114285714285714 2.92605965463108 0.0463732118527084 0.289079762198702 GO:0036122 BMP binding 3/728 21/18639 0.142857142857143 3.65757456828885 0.0467555852431407 0.28958297957042 GO:0005010 insulin-like growth factor receptor activity 5/728 51/18639 0.0980392156862745 2.51010019392372 0.0481116401211509 0.294185824944617 GO:0005030 neurotrophin receptor activity 5/728 51/18639 0.0980392156862745 2.51010019392372 0.0481116401211509 0.294185824944617 GO:0061133 endopeptidase activator activity 3/728 22/18639 0.136363636363636 3.49132117882118 0.052617478171694 0.319701133195103 GO:0038064 collagen receptor activity 5/728 53/18639 0.0943396226415094 2.41537943188887 0.0552184812612934 0.320087865422169 GO:0004955 prostaglandin receptor activity 2/728 10/18639 0.2 5.1206043956044 0.0556819515890648 0.320087865422169 GO:0005031 tumor necrosis factor receptor activity 2/728 10/18639 0.2 5.1206043956044 0.0556819515890648 0.320087865422169 GO:0005131 growth hormone receptor binding 2/728 10/18639 0.2 5.1206043956044 0.0556819515890648 0.320087865422169 GO:0005381 iron ion transmembrane transporter activity 2/728 10/18639 0.2 5.1206043956044 0.0556819515890648 0.320087865422169 GO:0005528 FK506 binding 2/728 10/18639 0.2 5.1206043956044 0.0556819515890648 0.320087865422169 GO:0008239 dipeptidyl-peptidase activity 2/728 10/18639 0.2 5.1206043956044 0.0556819515890648 0.320087865422169 GO:0035374 chondroitin sulfate binding 2/728 10/18639 0.2 5.1206043956044 0.0556819515890648 0.320087865422169 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/728 10/18639 0.2 5.1206043956044 0.0556819515890648 0.320087865422169 GO:0008237 metallopeptidase activity 12/728 184/18639 0.0652173913043478 1.66976230291448 0.0575310287896418 0.32874873594081 GO:0005212 structural constituent of eye lens 3/728 23/18639 0.130434782608696 3.33952460582895 0.0588144533613294 0.330186404835534 GO:0017134 fibroblast growth factor binding 3/728 23/18639 0.130434782608696 3.33952460582895 0.0588144533613294 0.330186404835534 GO:0044013 histone H2B acetyltransferase activity 3/728 23/18639 0.130434782608696 3.33952460582895 0.0588144533613294 0.330186404835534 GO:0019209 kinase activator activity 10/728 148/18639 0.0675675675675676 1.72993391743392 0.0649534833302165 0.351836001705911 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/728 24/18639 0.125 3.20037774725275 0.0653372906331813 0.351836001705911 GO:0030215 semaphorin receptor binding 3/728 24/18639 0.125 3.20037774725275 0.0653372906331813 0.351836001705911 GO:0001851 complement component C3b binding 2/728 11/18639 0.181818181818182 4.6550949050949 0.0663357461549686 0.351836001705911 GO:0004954 prostanoid receptor activity 2/728 11/18639 0.181818181818182 4.6550949050949 0.0663357461549686 0.351836001705911 GO:0005225 volume-sensitive anion channel activity 2/728 11/18639 0.181818181818182 4.6550949050949 0.0663357461549686 0.351836001705911 GO:0008199 ferric iron binding 2/728 11/18639 0.181818181818182 4.6550949050949 0.0663357461549686 0.351836001705911 GO:0010854 adenylate cyclase regulator activity 2/728 11/18639 0.181818181818182 4.6550949050949 0.0663357461549686 0.351836001705911 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/728 11/18639 0.181818181818182 4.6550949050949 0.0663357461549686 0.351836001705911 GO:0070697 activin receptor binding 2/728 11/18639 0.181818181818182 4.6550949050949 0.0663357461549686 0.351836001705911 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/728 40/18639 0.1 2.5603021978022 0.0696513259649487 0.367391609485444 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/728 25/18639 0.12 3.07236263736264 0.0721759725637904 0.374534776547236 GO:0017025 TBP-class protein binding 3/728 25/18639 0.12 3.07236263736264 0.0721759725637904 0.374534776547236 GO:0042974 nuclear retinoic acid receptor binding 3/728 25/18639 0.12 3.07236263736264 0.0721759725637904 0.374534776547236 GO:0042562 hormone binding 7/728 94/18639 0.074468085106383 1.90660801963993 0.0747884456478529 0.380072727750311 GO:0098631 cell adhesion mediator activity 6/728 76/18639 0.0789473684210526 2.02129120879121 0.0763489753830272 0.380072727750311 GO:0005025 transforming growth factor beta receptor activity, type I 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0005026 transforming growth factor beta receptor activity, type II 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0005095 GTPase inhibitor activity 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0005247 voltage-gated chloride channel activity 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0005527 macrolide binding 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0016361 activin receptor activity, type I 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0016362 activin receptor activity, type II 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0017002 activin receptor activity 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0070410 co-SMAD binding 2/728 12/18639 0.166666666666667 4.26717032967033 0.0775981819156885 0.380072727750311 GO:0004867 serine-type endopeptidase inhibitor activity 7/728 95/18639 0.0736842105263158 1.88653846153846 0.0781670228511669 0.380915441305179 GO:0019865 immunoglobulin binding 3/728 26/18639 0.115384615384615 2.95419484361792 0.0793197996187341 0.382648279567762 GO:0043548 phosphatidylinositol 3-kinase binding 3/728 26/18639 0.115384615384615 2.95419484361792 0.0793197996187341 0.382648279567762 GO:0004402 histone acetyltransferase activity 4/728 42/18639 0.0952380952380952 2.4383830455259 0.0803602043423959 0.3857289808435 GO:0004896 cytokine receptor activity 7/728 96/18639 0.0729166666666667 1.86688701923077 0.081633152749322 0.389889684772881 GO:0030246 carbohydrate binding 16/728 280/18639 0.0571428571428571 1.46302982731554 0.0834421720359515 0.396556857200562 GO:0004252 serine-type endopeptidase activity 11/728 176/18639 0.0625 1.60018887362637 0.0846602887275707 0.400363926987526 GO:0008200 ion channel inhibitor activity 4/728 43/18639 0.0930232558139535 2.38167646307181 0.0860025498541736 0.402353604756673 GO:0048156 tau protein binding 4/728 43/18639 0.0930232558139535 2.38167646307181 0.0860025498541736 0.402353604756673 GO:0004364 glutathione transferase activity 3/728 27/18639 0.111111111111111 2.84478021978022 0.0867574960256576 0.402353604756673 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/728 27/18639 0.111111111111111 2.84478021978022 0.0867574960256576 0.402353604756673 GO:0005035 death receptor activity 2/728 13/18639 0.153846153846154 3.93892645815723 0.0894056088210692 0.40295485665834 GO:0008035 high-density lipoprotein particle binding 2/728 13/18639 0.153846153846154 3.93892645815723 0.0894056088210692 0.40295485665834 GO:0019855 calcium channel inhibitor activity 2/728 13/18639 0.153846153846154 3.93892645815723 0.0894056088210692 0.40295485665834 GO:0031432 titin binding 2/728 13/18639 0.153846153846154 3.93892645815723 0.0894056088210692 0.40295485665834 GO:0035325 Toll-like receptor binding 2/728 13/18639 0.153846153846154 3.93892645815723 0.0894056088210692 0.40295485665834 GO:0035673 oligopeptide transmembrane transporter activity 2/728 13/18639 0.153846153846154 3.93892645815723 0.0894056088210692 0.40295485665834 GO:0016248 channel inhibitor activity 4/728 44/18639 0.0909090909090909 2.32754745254745 0.0918319217035218 0.410040208536656 GO:0030547 signaling receptor inhibitor activity 4/728 44/18639 0.0909090909090909 2.32754745254745 0.0918319217035218 0.410040208536656 GO:0036408 histone H3K14 acetyltransferase activity 3/728 28/18639 0.107142857142857 2.74318092621664 0.0944773069906853 0.418991566064839 GO:0030295 protein kinase activator activity 9/728 139/18639 0.0647482014388489 1.65774962447624 0.094709551912573 0.418991566064839 GO:0001618 virus receptor activity 6/728 81/18639 0.0740740740740741 1.89652014652015 0.096750387676308 0.42605675306998 GO:0005507 copper ion binding 5/728 63/18639 0.0793650793650794 2.03198587127159 0.0992460221579424 0.433340988167159 GO:0140272 exogenous protein binding 6/728 82/18639 0.0731707317073171 1.87339185205039 0.101147504757532 0.433340988167159 GO:0019763 immunoglobulin receptor activity 2/728 14/18639 0.142857142857143 3.65757456828885 0.101698408495727 0.433340988167159 GO:0042043 neurexin family protein binding 2/728 14/18639 0.142857142857143 3.65757456828885 0.101698408495727 0.433340988167159 GO:0044548 S100 protein binding 2/728 14/18639 0.142857142857143 3.65757456828885 0.101698408495727 0.433340988167159 GO:0098821 BMP receptor activity 2/728 14/18639 0.142857142857143 3.65757456828885 0.101698408495727 0.433340988167159 GO:0003785 actin monomer binding 3/728 29/18639 0.103448275862069 2.64858848048503 0.102467087827026 0.433340988167159 GO:0010484 histone H3 acetyltransferase activity 3/728 29/18639 0.103448275862069 2.64858848048503 0.102467087827026 0.433340988167159 GO:0043236 laminin binding 3/728 29/18639 0.103448275862069 2.64858848048503 0.102467087827026 0.433340988167159 GO:0008238 exopeptidase activity 7/728 102/18639 0.0686274509803922 1.75707013574661 0.10425015709293 0.43894802986497 GO:0061733 protein-lysine-acetyltransferase activity 4/728 47/18639 0.0851063829787234 2.17898059387421 0.110400219942677 0.454212863718269 GO:0001965 G-protein alpha-subunit binding 3/728 30/18639 0.1 2.5603021978022 0.110714385531328 0.454212863718269 GO:0043995 histone H4K5 acetyltransferase activity 3/728 30/18639 0.1 2.5603021978022 0.110714385531328 0.454212863718269 GO:0043996 histone H4K8 acetyltransferase activity 3/728 30/18639 0.1 2.5603021978022 0.110714385531328 0.454212863718269 GO:0043997 histone H4K12 acetyltransferase activity 3/728 30/18639 0.1 2.5603021978022 0.110714385531328 0.454212863718269 GO:0048019 receptor antagonist activity 3/728 30/18639 0.1 2.5603021978022 0.110714385531328 0.454212863718269 GO:0005096 GTPase activator activity 15/728 271/18639 0.0553505535055351 1.4171414378979 0.111485110601387 0.455428536924817 GO:0004953 icosanoid receptor activity 2/728 15/18639 0.133333333333333 3.41373626373626 0.114420777103982 0.463476565484484 GO:0031005 filamin binding 2/728 15/18639 0.133333333333333 3.41373626373626 0.114420777103982 0.463476565484484 GO:0008234 cysteine-type peptidase activity 11/728 187/18639 0.0588235294117647 1.50606011635423 0.11606213815653 0.468149800967517 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/728 86/18639 0.0697674418604651 1.78625734730386 0.119757048553353 0.481032496281249 GO:0016500 protein-hormone receptor activity 5/728 67/18639 0.0746268656716418 1.91067328194194 0.120633038281957 0.482532153127827 GO:0001664 G protein-coupled receptor binding 16/728 297/18639 0.0538720538720539 1.37928737928738 0.121919105441292 0.485652868147884 GO:0008081 phosphoric diester hydrolase activity 6/728 87/18639 0.0689655172413793 1.76572565365669 0.12465806845793 0.494511345948815 GO:1990841 promoter-specific chromatin binding 5/728 68/18639 0.0735294117647059 1.88257514544279 0.126291833805218 0.498930701452714 GO:0005159 insulin-like growth factor receptor binding 2/728 16/18639 0.125 3.20037774725275 0.127520518989484 0.50127915837263 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/728 32/18639 0.09375 2.40028331043956 0.127930618543015 0.50127915837263 GO:0005496 steroid binding 7/728 108/18639 0.0648148148148148 1.65945512820513 0.129896724672159 0.506914047501109 GO:0097110 scaffold protein binding 5/728 70/18639 0.0714285714285714 1.82878728414443 0.137965397576001 0.536221788149638 GO:0008236 serine-type peptidase activity 11/728 194/18639 0.0567010309278351 1.45171774102186 0.139065905840757 0.536948002212858 GO:0008484 sulfuric ester hydrolase activity 2/728 17/18639 0.117647058823529 3.01212023270847 0.140948850580875 0.536948002212858 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/728 17/18639 0.117647058823529 3.01212023270847 0.140948850580875 0.536948002212858 GO:0046965 nuclear retinoid X receptor binding 2/728 17/18639 0.117647058823529 3.01212023270847 0.140948850580875 0.536948002212858 GO:0051787 misfolded protein binding 2/728 17/18639 0.117647058823529 3.01212023270847 0.140948850580875 0.536948002212858 GO:1902936 phosphatidylinositol bisphosphate binding 7/728 111/18639 0.0630630630630631 1.61460498960499 0.14379848014203 0.5456385017247 GO:0005179 hormone activity 8/728 132/18639 0.0606060606060606 1.5516983016983 0.145274987383478 0.549070818457239 GO:0042379 chemokine receptor binding 5/728 72/18639 0.0694444444444444 1.77798763736264 0.150094211727368 0.558172201183964 GO:0005246 calcium channel regulator activity 4/728 53/18639 0.0754716981132075 1.93230354551109 0.151961477699563 0.558172201183964 GO:0034212 protein N-acetyltransferase activity 4/728 53/18639 0.0754716981132075 1.93230354551109 0.151961477699563 0.558172201183964 GO:0140296 general transcription initiation factor binding 4/728 53/18639 0.0754716981132075 1.93230354551109 0.151961477699563 0.558172201183964 GO:0017171 serine hydrolase activity 11/728 198/18639 0.0555555555555556 1.42239010989011 0.15322485691994 0.558172201183964 GO:0008308 voltage-gated monoatomic anion channel activity 2/728 18/18639 0.111111111111111 2.84478021978022 0.154660214078057 0.558172201183964 GO:0008409 5'-3' exonuclease activity 2/728 18/18639 0.111111111111111 2.84478021978022 0.154660214078057 0.558172201183964 GO:0017075 syntaxin-1 binding 2/728 18/18639 0.111111111111111 2.84478021978022 0.154660214078057 0.558172201183964 GO:0034185 apolipoprotein binding 2/728 18/18639 0.111111111111111 2.84478021978022 0.154660214078057 0.558172201183964 GO:0050811 GABA receptor binding 2/728 18/18639 0.111111111111111 2.84478021978022 0.154660214078057 0.558172201183964 GO:0070064 proline-rich region binding 2/728 18/18639 0.111111111111111 2.84478021978022 0.154660214078057 0.558172201183964 GO:0098641 cadherin binding involved in cell-cell adhesion 2/728 18/18639 0.111111111111111 2.84478021978022 0.154660214078057 0.558172201183964 GO:0016229 steroid dehydrogenase activity 3/728 35/18639 0.0857142857142857 2.19454474097331 0.155365043977009 0.558615888456662 GO:0017124 SH3 domain binding 7/728 115/18639 0.0608695652173913 1.55844481605351 0.163383147612869 0.579823342019089 GO:0035401 histone H3Y41 kinase activity 7/728 115/18639 0.0608695652173913 1.55844481605351 0.163383147612869 0.579823342019089 GO:0140801 histone H2AXY142 kinase activity 7/728 115/18639 0.0608695652173913 1.55844481605351 0.163383147612869 0.579823342019089 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/728 36/18639 0.0833333333333333 2.13358516483516 0.164887262886678 0.579823342019089 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/728 36/18639 0.0833333333333333 2.13358516483516 0.164887262886678 0.579823342019089 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/728 36/18639 0.0833333333333333 2.13358516483516 0.164887262886678 0.579823342019089 GO:0098632 cell-cell adhesion mediator activity 4/728 55/18639 0.0727272727272727 1.86203796203796 0.166968120438532 0.584997794237194 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/728 19/18639 0.105263157894737 2.69505494505495 0.168612100455793 0.588609514318405 GO:0016407 acetyltransferase activity 6/728 96/18639 0.0625 1.60018887362637 0.172895744874778 0.601376503912272 GO:0017022 myosin binding 5/728 76/18639 0.0657894736842105 1.68440934065934 0.175617476856191 0.608638186938424 GO:0010851 cyclase regulator activity 2/728 20/18639 0.1 2.5603021978022 0.182764881342597 0.626622450317475 GO:0016004 phospholipase activator activity 2/728 20/18639 0.1 2.5603021978022 0.182764881342597 0.626622450317475 GO:0140939 histone H4 methyltransferase activity 2/728 20/18639 0.1 2.5603021978022 0.182764881342597 0.626622450317475 GO:1901981 phosphatidylinositol phosphate binding 10/728 185/18639 0.0540540540540541 1.38394713394713 0.188279772259007 0.643233385653549 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/728 39/18639 0.0769230769230769 1.96946322907861 0.194406331402898 0.650855589142164 GO:0051015 actin filament binding 11/728 209/18639 0.0526315789473684 1.34752747252747 0.195707680264498 0.650855589142164 GO:0001846 opsonin binding 2/728 21/18639 0.0952380952380952 2.4383830455259 0.197081649353066 0.650855589142164 GO:0005248 voltage-gated sodium channel activity 2/728 21/18639 0.0952380952380952 2.4383830455259 0.197081649353066 0.650855589142164 GO:0009975 cyclase activity 2/728 21/18639 0.0952380952380952 2.4383830455259 0.197081649353066 0.650855589142164 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/728 21/18639 0.0952380952380952 2.4383830455259 0.197081649353066 0.650855589142164 GO:0051010 microtubule plus-end binding 2/728 21/18639 0.0952380952380952 2.4383830455259 0.197081649353066 0.650855589142164 GO:0072542 protein phosphatase activator activity 2/728 21/18639 0.0952380952380952 2.4383830455259 0.197081649353066 0.650855589142164 GO:0001786 phosphatidylserine binding 4/728 59/18639 0.0677966101694915 1.73579810020488 0.19843037795264 0.650855589142164 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 4/728 59/18639 0.0677966101694915 1.73579810020488 0.19843037795264 0.650855589142164 GO:0070888 E-box binding 4/728 59/18639 0.0677966101694915 1.73579810020488 0.19843037795264 0.650855589142164 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/728 122/18639 0.0573770491803279 1.46902585119798 0.200289374044162 0.650855589142164 GO:0048306 calcium-dependent protein binding 5/728 80/18639 0.0625 1.60018887362637 0.202648806614799 0.650855589142164 GO:0008194 UDP-glycosyltransferase activity 8/728 145/18639 0.0551724137931034 1.41258052292535 0.20694817888715 0.650855589142164 GO:0019902 phosphatase binding 10/728 190/18639 0.0526315789473684 1.34752747252747 0.210094346996423 0.650855589142164 GO:0005243 gap junction channel activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0032931 histone H3K56 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0043992 histone H3K9 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0043993 histone H3K18 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0043994 histone H3K23 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0043999 histone H2AK5 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0044012 histone H2AK9 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0044014 histone H2BK5 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0044015 histone H2BK12 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0044016 histone H3K4 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0044017 histone H3K27 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0044018 histone H3K36 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0046972 histone H4K16 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0140517 protein-RNA adaptor activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0140908 histone H3K122 acetyltransferase activity 2/728 22/18639 0.0909090909090909 2.32754745254745 0.211528066471203 0.650855589142164 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/728 61/18639 0.0655737704918033 1.67888668708341 0.214789061567625 0.658777952411886 GO:0141108 transporter regulator activity 9/728 170/18639 0.0529411764705882 1.35545410471881 0.221142936195403 0.676103835815222 GO:0005254 chloride channel activity 5/728 83/18639 0.0602409638554217 1.54235072156759 0.22377530952433 0.676103835815222 GO:0016859 cis-trans isomerase activity 3/728 42/18639 0.0714285714285714 1.82878728414443 0.225092203628647 0.676103835815222 GO:0042056 chemoattractant activity 3/728 42/18639 0.0714285714285714 1.82878728414443 0.225092203628647 0.676103835815222 GO:0004602 glutathione peroxidase activity 2/728 23/18639 0.0869565217391304 2.2263497372193 0.226072220100715 0.676103835815222 GO:0005158 insulin receptor binding 2/728 23/18639 0.0869565217391304 2.2263497372193 0.226072220100715 0.676103835815222 GO:0008171 O-methyltransferase activity 2/728 23/18639 0.0869565217391304 2.2263497372193 0.226072220100715 0.676103835815222 GO:0016849 phosphorus-oxygen lyase activity 2/728 23/18639 0.0869565217391304 2.2263497372193 0.226072220100715 0.676103835815222 GO:0004527 exonuclease activity 5/728 84/18639 0.0595238095238095 1.52398940345369 0.230960419440494 0.688577648021347 GO:0019842 vitamin binding 8/728 150/18639 0.0533333333333333 1.36549450549451 0.233056636301012 0.689722707341216 GO:0019207 kinase regulator activity 14/728 287/18639 0.0487804878048781 1.24892790136693 0.233630360062873 0.689722707341216 GO:0000149 SNARE binding 6/728 106/18639 0.0566037735849057 1.44922765913332 0.233903173716625 0.689722707341216 GO:0031490 chromatin DNA binding 7/728 128/18639 0.0546875 1.40016526442308 0.234236251329882 0.689722707341216 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0004806 triacylglycerol lipase activity 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0005540 hyaluronic acid binding 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0043998 histone H2A acetyltransferase activity 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0048027 mRNA 5'-UTR binding 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0050699 WW domain binding 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0060229 lipase activator activity 2/728 24/18639 0.0833333333333333 2.13358516483516 0.240684486415945 0.689722707341216 GO:0016298 lipase activity 7/728 130/18639 0.0538461538461538 1.37862426035503 0.245956306448865 0.698806088174734 GO:0001046 core promoter sequence-specific DNA binding 3/728 44/18639 0.0681818181818182 1.74566058941059 0.246037976878188 0.698806088174734 GO:0043014 alpha-tubulin binding 3/728 44/18639 0.0681818181818182 1.74566058941059 0.246037976878188 0.698806088174734 GO:0001848 complement binding 2/728 25/18639 0.08 2.04824175824176 0.255337400663959 0.716157886117743 GO:0015662 P-type ion transporter activity 2/728 25/18639 0.08 2.04824175824176 0.255337400663959 0.716157886117743 GO:0019211 phosphatase activator activity 2/728 25/18639 0.08 2.04824175824176 0.255337400663959 0.716157886117743 GO:0140358 P-type transmembrane transporter activity 2/728 25/18639 0.08 2.04824175824176 0.255337400663959 0.716157886117743 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/728 45/18639 0.0666666666666667 1.70686813186813 0.256623242525525 0.716157886117743 GO:0046915 transition metal ion transmembrane transporter activity 3/728 45/18639 0.0666666666666667 1.70686813186813 0.256623242525525 0.716157886117743 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 7/728 132/18639 0.053030303030303 1.35773601398601 0.257853978151148 0.717506721811889 GO:0030291 protein serine/threonine kinase inhibitor activity 3/728 46/18639 0.0652173913043478 1.66976230291448 0.267268918466691 0.736378729321074 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/728 26/18639 0.0769230769230769 1.96946322907861 0.270005534084394 0.736378729321074 GO:0005227 calcium-activated cation channel activity 2/728 26/18639 0.0769230769230769 1.96946322907861 0.270005534084394 0.736378729321074 GO:0008143 poly(A) binding 2/728 26/18639 0.0769230769230769 1.96946322907861 0.270005534084394 0.736378729321074 GO:0008198 ferrous iron binding 2/728 26/18639 0.0769230769230769 1.96946322907861 0.270005534084394 0.736378729321074 GO:0050750 low-density lipoprotein particle receptor binding 2/728 26/18639 0.0769230769230769 1.96946322907861 0.270005534084394 0.736378729321074 GO:0070006 metalloaminopeptidase activity 2/728 26/18639 0.0769230769230769 1.96946322907861 0.270005534084394 0.736378729321074 GO:0005200 structural constituent of cytoskeleton 6/728 112/18639 0.0535714285714286 1.37159046310832 0.273307340357457 0.743272087091101 GO:0003714 transcription corepressor activity 10/728 204/18639 0.0490196078431373 1.25505009696186 0.276065159040977 0.747467594078317 GO:0030695 GTPase regulator activity 22/728 489/18639 0.0449897750511247 1.15187419942021 0.277203504626572 0.747467594078317 GO:0001784 phosphotyrosine residue binding 3/728 47/18639 0.0638297872340425 1.63423544540566 0.277964511547874 0.747467594078317 GO:0099095 ligand-gated monoatomic anion channel activity 3/728 47/18639 0.0638297872340425 1.63423544540566 0.277964511547874 0.747467594078317 GO:0060589 nucleoside-triphosphatase regulator activity 22/728 490/18639 0.0448979591836735 1.14952343574793 0.280379499752011 0.750765829791014 GO:0072341 modified amino acid binding 5/728 91/18639 0.0549450549450549 1.40675944934187 0.28287589715162 0.750765829791014 GO:0008080 N-acetyltransferase activity 4/728 69/18639 0.0579710144927536 1.4842331581462 0.283276428434938 0.750765829791014 GO:0001671 ATPase activator activity 2/728 27/18639 0.0740740740740741 1.89652014652015 0.284665377129093 0.750765829791014 GO:0005104 fibroblast growth factor receptor binding 2/728 27/18639 0.0740740740740741 1.89652014652015 0.284665377129093 0.750765829791014 GO:0008266 poly(U) RNA binding 2/728 27/18639 0.0740740740740741 1.89652014652015 0.284665377129093 0.750765829791014 GO:0035255 ionotropic glutamate receptor binding 2/728 27/18639 0.0740740740740741 1.89652014652015 0.284665377129093 0.750765829791014 GO:0099106 ion channel regulator activity 8/728 160/18639 0.05 1.2801510989011 0.288320523995209 0.755182169036577 GO:0032266 phosphatidylinositol-3-phosphate binding 3/728 48/18639 0.0625 1.60018887362637 0.288699850037941 0.755182169036577 GO:0038187 pattern recognition receptor activity 3/728 48/18639 0.0625 1.60018887362637 0.288699850037941 0.755182169036577 GO:0019887 protein kinase regulator activity 12/728 255/18639 0.0470588235294118 1.20484809308339 0.29541135936042 0.758492173654024 GO:0051213 dioxygenase activity 5/728 93/18639 0.0537634408602151 1.37650655795817 0.298118486848608 0.758492173654024 GO:0051219 phosphoprotein binding 5/728 93/18639 0.0537634408602151 1.37650655795817 0.298118486848608 0.758492173654024 GO:0046966 nuclear thyroid hormone receptor binding 2/728 28/18639 0.0714285714285714 1.82878728414443 0.299295228678202 0.758492173654024 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/728 28/18639 0.0714285714285714 1.82878728414443 0.299295228678202 0.758492173654024 GO:0097718 disordered domain specific binding 2/728 28/18639 0.0714285714285714 1.82878728414443 0.299295228678202 0.758492173654024 GO:0060590 ATPase regulator activity 3/728 49/18639 0.0612244897959184 1.56753195783808 0.299465090299417 0.758492173654024 GO:0019208 phosphatase regulator activity 6/728 117/18639 0.0512820512820513 1.31297548605241 0.307258878286687 0.758492173654024 GO:0141003 histone H2AX kinase activity 16/728 354/18639 0.0451977401129944 1.15719873346992 0.310110955903237 0.758492173654024 GO:0008276 protein methyltransferase activity 5/728 95/18639 0.0526315789473684 1.34752747252747 0.313489681101244 0.758492173654024 GO:0051861 glycolipid binding 2/728 29/18639 0.0689655172413793 1.76572565365669 0.313875090963473 0.758492173654024 GO:0005272 sodium channel activity 3/728 51/18639 0.0588235294117647 1.50606011635423 0.32104757088686 0.758492173654024 GO:0016597 amino acid binding 3/728 51/18639 0.0588235294117647 1.50606011635423 0.32104757088686 0.758492173654024 GO:0140996 histone H3 kinase activity 16/728 357/18639 0.0448179271708683 1.14747437436513 0.321903202771429 0.758492173654024 GO:0008187 poly-pyrimidine tract binding 2/728 30/18639 0.0666666666666667 1.70686813186813 0.328386569922913 0.758492173654024 GO:0022839 monoatomic ion-gated channel activity 2/728 30/18639 0.0666666666666667 1.70686813186813 0.328386569922913 0.758492173654024 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/728 30/18639 0.0666666666666667 1.70686813186813 0.328386569922913 0.758492173654024 GO:0070566 adenylyltransferase activity 2/728 30/18639 0.0666666666666667 1.70686813186813 0.328386569922913 0.758492173654024 GO:0000182 rDNA binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0001094 TFIID-class transcription factor complex binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0003796 lysozyme activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0004090 carbonyl reductase (NADPH) activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0004935 adrenergic receptor activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0005522 profilin binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0008140 cAMP response element binding protein binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0008401 retinoic acid 4-hydroxylase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0008519 ammonium channel activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0015279 store-operated calcium channel activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0030957 Tat protein binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0033204 ribonuclease P RNA binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0042975 peroxisome proliferator activated receptor binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0043121 neurotrophin binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0043208 glycosphingolipid binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0043295 glutathione binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0047429 nucleoside triphosphate diphosphatase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0050308 sugar-phosphatase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0051880 G-quadruplex DNA binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0070097 delta-catenin binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0098505 G-rich strand telomeric DNA binding 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0140940 histone H2A methyltransferase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:1990259 histone H2AQ104 methyltransferase activity 1/728 10/18639 0.1 2.5603021978022 0.328679941916744 0.758492173654024 GO:0005080 protein kinase C binding 3/728 52/18639 0.0576923076923077 1.47709742180896 0.331846802605782 0.76396386211403 GO:0035173 histone kinase activity 16/728 360/18639 0.0444444444444444 1.13791208791209 0.333809242467271 0.76664323628847 GO:0016247 channel regulator activity 8/728 168/18639 0.0476190476190476 1.21919152276295 0.334648312735454 0.766735990992926 GO:0005164 tumor necrosis factor receptor binding 2/728 31/18639 0.0645161290322581 1.65180786954981 0.342812780723673 0.769114643415812 GO:0070325 lipoprotein particle receptor binding 2/728 31/18639 0.0645161290322581 1.65180786954981 0.342812780723673 0.769114643415812 GO:0042578 phosphoric ester hydrolase activity 16/728 363/18639 0.0440771349862259 1.12850785578058 0.34581676310065 0.769114643415812 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/728 54/18639 0.0555555555555556 1.42239010989011 0.353418774289466 0.769114643415812 GO:0004016 adenylate cyclase activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0005536 D-glucose binding 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0008046 axon guidance receptor activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0008172 S-methyltransferase activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0015173 aromatic amino acid transmembrane transporter activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0019203 carbohydrate phosphatase activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0019215 intermediate filament binding 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0034056 estrogen response element binding 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0035252 UDP-xylosyltransferase activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0042285 xylosyltransferase activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0043522 leucine zipper domain binding 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0050998 nitric-oxide synthase binding 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:1900750 oligopeptide binding 1/728 11/18639 0.0909090909090909 2.32754745254745 0.354914361492921 0.769114643415812 GO:0070717 poly-purine tract binding 2/728 32/18639 0.0625 1.60018887362637 0.357138258202384 0.769873262324394 GO:0071889 14-3-3 protein binding 2/728 33/18639 0.0606060606060606 1.5516983016983 0.371348871983702 0.769873262324394 GO:0170055 lipid transmembrane transporter activity 3/728 56/18639 0.0535714285714286 1.37159046310832 0.374902747829269 0.769873262324394 GO:0005253 monoatomic anion channel activity 5/728 103/18639 0.0485436893203883 1.24286514456417 0.375704293837022 0.769873262324394 GO:0004526 ribonuclease P activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0004859 phospholipase inhibitor activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0005049 nuclear export signal receptor activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0005165 neurotrophin receptor binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0008179 adenylate cyclase binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0008603 cAMP-dependent protein kinase regulator activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0010853 cyclase activator activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0015132 prostaglandin transmembrane transporter activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0015166 polyol transmembrane transporter activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0015269 calcium-activated potassium channel activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0016208 AMP binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0016273 arginine N-methyltransferase activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0016274 protein-arginine N-methyltransferase activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0016801 hydrolase activity, acting on ether bonds 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0016803 ether hydrolase activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0016840 carbon-nitrogen lyase activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0017166 vinculin binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0035251 UDP-glucosyltransferase activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0036009 protein-glutamine N-methyltransferase activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0043047 single-stranded telomeric DNA binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0045295 gamma-catenin binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0070679 inositol 1,4,5 trisphosphate binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0097677 STAT family protein binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:1990459 transferrin receptor binding 1/728 12/18639 0.0833333333333333 2.13358516483516 0.38012492327267 0.769873262324394 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 6/728 128/18639 0.046875 1.20014165521978 0.383885347601457 0.774088862357969 GO:0015020 glucuronosyltransferase activity 2/728 34/18639 0.0588235294117647 1.50606011635423 0.385431746049072 0.774088862357969 GO:0015035 protein-disulfide reductase activity 2/728 34/18639 0.0588235294117647 1.50606011635423 0.385431746049072 0.774088862357969 GO:0051427 hormone receptor binding 2/728 34/18639 0.0588235294117647 1.50606011635423 0.385431746049072 0.774088862357969 GO:0004465 lipoprotein lipase activity 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0004535 poly(A)-specific ribonuclease activity 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0005172 vascular endothelial growth factor receptor binding 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0030955 potassium ion binding 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0039706 co-receptor binding 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0045159 myosin II binding 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0046974 histone H3K9 methyltransferase activity 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0046975 histone H3K36 methyltransferase activity 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0051011 microtubule minus-end binding 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0061459 L-arginine transmembrane transporter activity 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0071714 icosanoid transmembrane transporter activity 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0071837 HMG box domain binding 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0140666 annealing activity 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:1901338 catecholamine binding 1/728 13/18639 0.0769230769230769 1.96946322907861 0.404351532810303 0.785306096314918 GO:0031072 heat shock protein binding 6/728 131/18639 0.0458015267175573 1.17265749517658 0.404923455912379 0.785306096314918 GO:0045309 protein phosphorylated amino acid binding 3/728 59/18639 0.0508474576271186 1.30184857515366 0.406837169463051 0.787426779605905 GO:0004190 aspartic-type endopeptidase activity 2/728 36/18639 0.0555555555555556 1.42239010989011 0.413168589576618 0.789889248783555 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/728 36/18639 0.0555555555555556 1.42239010989011 0.413168589576618 0.789889248783555 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/728 60/18639 0.05 1.2801510989011 0.417377941267534 0.789889248783555 GO:0140658 ATP-dependent chromatin remodeler activity 7/728 158/18639 0.0443037974683544 1.13431110029211 0.421787635504003 0.789889248783555 GO:0004620 phospholipase activity 5/728 109/18639 0.0458715596330275 1.17445054945055 0.422404203363052 0.789889248783555 GO:0022829 wide pore channel activity 2/728 37/18639 0.0540540540540541 1.38394713394713 0.426802412929951 0.789889248783555 GO:0030551 cyclic nucleotide binding 2/728 37/18639 0.0540540540540541 1.38394713394713 0.426802412929951 0.789889248783555 GO:0042805 actinin binding 2/728 37/18639 0.0540540540540541 1.38394713394713 0.426802412929951 0.789889248783555 GO:0070001 aspartic-type peptidase activity 2/728 37/18639 0.0540540540540541 1.38394713394713 0.426802412929951 0.789889248783555 GO:0004065 arylsulfatase activity 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0004705 JUN kinase activity 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0005545 1-phosphatidylinositol binding 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0008195 phosphatidate phosphatase activity 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0016530 metallochaperone activity 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0031404 chloride ion binding 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0032036 myosin heavy chain binding 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0032454 histone H3K9 demethylase activity 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0034236 protein kinase A catalytic subunit binding 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0061783 peptidoglycan muralytic activity 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0071933 Arp2/3 complex binding 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0098847 sequence-specific single stranded DNA binding 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:1901612 cardiolipin binding 1/728 14/18639 0.0714285714285714 1.82878728414443 0.427632542372962 0.789889248783555 GO:0019905 syntaxin binding 3/728 61/18639 0.0491803278688525 1.25916501531256 0.427856676424426 0.789889248783555 GO:0035091 phosphatidylinositol binding 12/728 284/18639 0.0422535211267606 1.08181783005727 0.432021382202499 0.79604707661113 GO:0016209 antioxidant activity 4/728 86/18639 0.0465116279069767 1.19083823153591 0.434378975944452 0.798529794580254 GO:0015631 tubulin binding 16/728 385/18639 0.0415584415584416 1.06402169259312 0.435787835442939 0.798529794580254 GO:0015179 L-amino acid transmembrane transporter activity 3/728 62/18639 0.0483870967741935 1.23885590216235 0.43826783194108 0.798529794580254 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/728 38/18639 0.0526315789473684 1.34752747252747 0.440268071299683 0.798529794580254 GO:0042887 amide transmembrane transporter activity 2/728 38/18639 0.0526315789473684 1.34752747252747 0.440268071299683 0.798529794580254 GO:0000774 adenyl-nucleotide exchange factor activity 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0004559 alpha-mannosidase activity 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0015250 water channel activity 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0015929 hexosaminidase activity 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0016846 carbon-sulfur lyase activity 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0030553 cGMP binding 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0033130 acetylcholine receptor binding 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0034483 heparan sulfate sulfotransferase activity 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0047372 monoacylglycerol lipase activity 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0050700 CARD domain binding 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0051371 muscle alpha-actinin binding 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0120283 protein serine/threonine kinase binding 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0140776 protein-containing complex destabilizing activity 1/728 15/18639 0.0666666666666667 1.70686813186813 0.450004811320747 0.798529794580254 GO:0000217 DNA secondary structure binding 2/728 39/18639 0.0512820512820513 1.31297548605241 0.453557895077887 0.799688353797743 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/728 39/18639 0.0512820512820513 1.31297548605241 0.453557895077887 0.799688353797743 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/728 89/18639 0.0449438202247191 1.15069761698975 0.460491180666762 0.799688353797743 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/728 89/18639 0.0449438202247191 1.15069761698975 0.460491180666762 0.799688353797743 GO:0004177 aminopeptidase activity 2/728 40/18639 0.05 1.2801510989011 0.466665068391771 0.799688353797743 GO:0004532 RNA exonuclease activity 2/728 40/18639 0.05 1.2801510989011 0.466665068391771 0.799688353797743 GO:0015036 disulfide oxidoreductase activity 2/728 40/18639 0.05 1.2801510989011 0.466665068391771 0.799688353797743 GO:0019843 rRNA binding 3/728 65/18639 0.0461538461538462 1.18167793744717 0.469044907664476 0.799688353797743 GO:0140793 histone H2AXY142 phosphatase activity 4/728 90/18639 0.0444444444444444 1.13791208791209 0.469104173133492 0.799688353797743 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0004707 MAP kinase activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0004708 MAP kinase kinase activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0005149 interleukin-1 receptor binding 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0005521 lamin binding 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0008142 oxysterol binding 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0015562 efflux transmembrane transporter activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0015923 mannosidase activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0016722 oxidoreductase activity, acting on metal ions 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0022841 potassium ion leak channel activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0022858 alanine transmembrane transporter activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0030275 LRR domain binding 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0055102 lipase inhibitor activity 1/728 16/18639 0.0625 1.60018887362637 0.471503764142831 0.799688353797743 GO:0008235 metalloexopeptidase activity 3/728 66/18639 0.0454545454545455 1.16377372627373 0.479136290216153 0.799688353797743 GO:0001530 lipopolysaccharide binding 2/728 41/18639 0.0487804878048781 1.24892790136693 0.479583574274445 0.799688353797743 GO:0001727 lipid kinase activity 2/728 41/18639 0.0487804878048781 1.24892790136693 0.479583574274445 0.799688353797743 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/728 41/18639 0.0487804878048781 1.24892790136693 0.479583574274445 0.799688353797743 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/728 41/18639 0.0487804878048781 1.24892790136693 0.479583574274445 0.799688353797743 GO:0017080 sodium channel regulator activity 2/728 41/18639 0.0487804878048781 1.24892790136693 0.479583574274445 0.799688353797743 GO:0042169 SH2 domain binding 2/728 41/18639 0.0487804878048781 1.24892790136693 0.479583574274445 0.799688353797743 GO:0042287 MHC protein binding 2/728 41/18639 0.0487804878048781 1.24892790136693 0.479583574274445 0.799688353797743 GO:0020037 heme binding 6/728 142/18639 0.0422535211267606 1.08181783005727 0.481177750352987 0.799688353797743 GO:0042054 histone methyltransferase activity 3/728 67/18639 0.0447761194029851 1.14640396916516 0.489136799794603 0.799688353797743 GO:0004549 tRNA-specific ribonuclease activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0004550 nucleoside diphosphate kinase activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0004659 prenyltransferase activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0005092 GDP-dissociation inhibitor activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0016018 cyclosporin A binding 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0016805 dipeptidase activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0019198 transmembrane receptor protein phosphatase activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0030548 acetylcholine receptor regulator activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0036041 long-chain fatty acid binding 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0045125 bioactive lipid receptor activity 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0048038 quinone binding 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0070403 NAD+ binding 1/728 17/18639 0.0588235294117647 1.50606011635423 0.492163446240453 0.799688353797743 GO:0008307 structural constituent of muscle 2/728 42/18639 0.0476190476190476 1.21919152276295 0.492308142806735 0.799688353797743 GO:0051879 Hsp90 protein binding 2/728 42/18639 0.0476190476190476 1.21919152276295 0.492308142806735 0.799688353797743 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/728 68/18639 0.0441176470588235 1.12954508726568 0.4990426127868 0.807893605860586 GO:0032934 sterol binding 3/728 68/18639 0.0441176470588235 1.12954508726568 0.4990426127868 0.807893605860586 GO:0016410 N-acyltransferase activity 4/728 94/18639 0.0425531914893617 1.08949029693711 0.503019628279462 0.810437679505284 GO:0008375 acetylglucosaminyltransferase activity 2/728 43/18639 0.0465116279069767 1.19083823153591 0.504834202082101 0.810437679505284 GO:0016279 protein-lysine N-methyltransferase activity 3/728 69/18639 0.0434782608695652 1.11317486860965 0.508850166620975 0.810437679505284 GO:0000400 four-way junction DNA binding 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:0005372 water transmembrane transporter activity 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:0015172 acidic amino acid transmembrane transporter activity 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:0016854 racemase and epimerase activity 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:0017128 phospholipid scramblase activity 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:0031690 adrenergic receptor binding 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:0035615 clathrin adaptor activity 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:0099602 neurotransmitter receptor regulator activity 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:1901611 phosphatidylglycerol binding 1/728 18/18639 0.0555555555555556 1.42239010989011 0.512016577544124 0.810437679505284 GO:0003697 single-stranded DNA binding 5/728 121/18639 0.0413223140495868 1.0579761147943 0.513277197020013 0.810437679505284 GO:0015108 chloride transmembrane transporter activity 5/728 121/18639 0.0413223140495868 1.0579761147943 0.513277197020013 0.810437679505284 GO:0051082 unfolded protein binding 5/728 121/18639 0.0413223140495868 1.0579761147943 0.513277197020013 0.810437679505284 GO:0003954 NADH dehydrogenase activity 2/728 44/18639 0.0454545454545455 1.16377372627373 0.517157831853716 0.811839391695496 GO:0019205 nucleobase-containing compound kinase activity 2/728 44/18639 0.0454545454545455 1.16377372627373 0.517157831853716 0.811839391695496 GO:0016278 lysine N-methyltransferase activity 3/728 70/18639 0.0428571428571429 1.09727237048666 0.518556152100516 0.811839391695496 GO:0004674 protein serine/threonine kinase activity 17/728 433/18639 0.0392609699769053 1.00519947719717 0.526550580426248 0.811839391695496 GO:0140299 molecular sensor activity 3/728 71/18639 0.0422535211267606 1.08181783005727 0.528157505671129 0.811839391695496 GO:0003756 protein disulfide isomerase activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0008574 plus-end-directed microtubule motor activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0015245 fatty acid transmembrane transporter activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0022840 leak channel activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0022842 narrow pore channel activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0030506 ankyrin binding 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0031420 alkali metal ion binding 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0034987 immunoglobulin receptor binding 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0042577 lipid phosphatase activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0042800 histone H3K4 methyltransferase activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0042834 peptidoglycan binding 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0046527 glucosyltransferase activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0050145 nucleoside monophosphate kinase activity 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0097001 ceramide binding 1/728 19/18639 0.0526315789473684 1.34752747252747 0.531094604049031 0.811839391695496 GO:0003924 GTPase activity 13/728 331/18639 0.0392749244712991 1.00555675442382 0.531923934767153 0.811839391695496 GO:0004725 protein tyrosine phosphatase activity 4/728 98/18639 0.0408163265306122 1.04502130522539 0.535949235902361 0.815390279661278 GO:0008170 N-methyltransferase activity 4/728 98/18639 0.0408163265306122 1.04502130522539 0.535949235902361 0.815390279661278 GO:0004180 carboxypeptidase activity 2/728 46/18639 0.0434782608695652 1.11317486860965 0.541185119786844 0.822053346511662 GO:0045296 cadherin binding 13/728 334/18639 0.0389221556886228 0.996524807527802 0.545176928162113 0.826808611430693 GO:0043539 protein serine/threonine kinase activator activity 3/728 73/18639 0.0410958904109589 1.05217898539816 0.547035244430961 0.828022978736884 GO:0046906 tetrapyrrole binding 6/728 152/18639 0.0394736842105263 1.0106456043956 0.547759550598795 0.828022978736884 GO:0030742 GTP-dependent protein binding 1/728 20/18639 0.05 1.2801510989011 0.54942774734937 0.828022978736884 GO:0031418 L-ascorbic acid binding 1/728 20/18639 0.05 1.2801510989011 0.54942774734937 0.828022978736884 GO:0043495 protein-membrane adaptor activity 2/728 47/18639 0.0425531914893617 1.08949029693711 0.552883813486354 0.830623569556963 GO:0140938 histone H3 methyltransferase activity 2/728 47/18639 0.0425531914893617 1.08949029693711 0.552883813486354 0.830623569556963 GO:0035064 methylated histone binding 3/728 74/18639 0.0405405405405405 1.03796035046035 0.556306660720489 0.83108893154079 GO:0048029 monosaccharide binding 3/728 74/18639 0.0405405405405405 1.03796035046035 0.556306660720489 0.83108893154079 GO:0042826 histone deacetylase binding 5/728 127/18639 0.0393700787401575 1.00799299126071 0.556480509269964 0.83108893154079 GO:0016853 isomerase activity 7/728 180/18639 0.0388888888888889 0.995673076923077 0.558592771350398 0.83108893154079 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/728 48/18639 0.0416666666666667 1.06679258241758 0.56437007276672 0.83108893154079 GO:0140693 molecular condensate scaffold activity 2/728 48/18639 0.0416666666666667 1.06679258241758 0.56437007276672 0.83108893154079 GO:0003725 double-stranded RNA binding 3/728 75/18639 0.04 1.02412087912088 0.565463491771139 0.83108893154079 GO:0044183 protein folding chaperone 3/728 75/18639 0.04 1.02412087912088 0.565463491771139 0.83108893154079 GO:0004386 helicase activity 6/728 155/18639 0.0387096774193548 0.991084721729883 0.566987934058482 0.83108893154079 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/728 21/18639 0.0476190476190476 1.21919152276295 0.567045052249185 0.83108893154079 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/728 21/18639 0.0476190476190476 1.21919152276295 0.567045052249185 0.83108893154079 GO:0010314 phosphatidylinositol-5-phosphate binding 1/728 21/18639 0.0476190476190476 1.21919152276295 0.567045052249185 0.83108893154079 GO:0015174 basic amino acid transmembrane transporter activity 1/728 21/18639 0.0476190476190476 1.21919152276295 0.567045052249185 0.83108893154079 GO:0019200 carbohydrate kinase activity 1/728 21/18639 0.0476190476190476 1.21919152276295 0.567045052249185 0.83108893154079 GO:0061891 calcium ion sensor activity 1/728 21/18639 0.0476190476190476 1.21919152276295 0.567045052249185 0.83108893154079 GO:0140312 cargo adaptor activity 1/728 21/18639 0.0476190476190476 1.21919152276295 0.567045052249185 0.83108893154079 GO:0140034 methylation-dependent protein binding 3/728 76/18639 0.0394736842105263 1.0106456043956 0.574503785684709 0.837181840611857 GO:0001222 transcription corepressor binding 2/728 49/18639 0.0408163265306122 1.04502130522539 0.575642625212137 0.837181840611857 GO:0016763 pentosyltransferase activity 2/728 49/18639 0.0408163265306122 1.04502130522539 0.575642625212137 0.837181840611857 GO:0035254 glutamate receptor binding 2/728 49/18639 0.0408163265306122 1.04502130522539 0.575642625212137 0.837181840611857 GO:0046982 protein heterodimerization activity 14/728 369/18639 0.037940379403794 0.971388367729831 0.582868306799537 0.837181840611857 GO:0003724 RNA helicase activity 3/728 77/18639 0.038961038961039 0.997520336806051 0.583425789769483 0.837181840611857 GO:0008093 cytoskeletal anchor activity 1/728 22/18639 0.0454545454545455 1.16377372627373 0.583974432524327 0.837181840611857 GO:0008970 phospholipase A1 activity 1/728 22/18639 0.0454545454545455 1.16377372627373 0.583974432524327 0.837181840611857 GO:0070034 telomerase RNA binding 1/728 22/18639 0.0454545454545455 1.16377372627373 0.583974432524327 0.837181840611857 GO:0140784 metal ion sensor activity 1/728 22/18639 0.0454545454545455 1.16377372627373 0.583974432524327 0.837181840611857 GO:0032813 tumor necrosis factor receptor superfamily binding 2/728 50/18639 0.04 1.02412087912088 0.58670062118596 0.837181840611857 GO:0048020 CCR chemokine receptor binding 2/728 50/18639 0.04 1.02412087912088 0.58670062118596 0.837181840611857 GO:0003743 translation initiation factor activity 2/728 51/18639 0.0392156862745098 1.00404007756949 0.597543602830821 0.837181840611857 GO:0015079 potassium ion transmembrane transporter activity 6/728 160/18639 0.0375 0.960113324175824 0.598127388946622 0.837181840611857 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:0005283 amino acid:sodium symporter activity 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:0016493 C-C chemokine receptor activity 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:0031681 G-protein beta-subunit binding 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:0042171 lysophosphatidic acid acyltransferase activity 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:0070577 lysine-acetylated histone binding 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:0071617 lysophospholipid acyltransferase activity 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/728 23/18639 0.0434782608695652 1.11317486860965 0.600242714907218 0.837181840611857 GO:0008186 ATP-dependent activity, acting on RNA 3/728 79/18639 0.0379746835443038 0.97226665739324 0.600908868432114 0.837181840611857 GO:0019888 protein phosphatase regulator activity 4/728 107/18639 0.0373831775700935 0.957122316935401 0.605738507925287 0.837181840611857 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 9/728 243/18639 0.037037037037037 0.948260073260073 0.61194948211817 0.837181840611857 GO:0004622 lysophospholipase activity 1/728 24/18639 0.0416666666666667 1.06679258241758 0.615875681363361 0.837181840611857 GO:0019957 C-C chemokine binding 1/728 24/18639 0.0416666666666667 1.06679258241758 0.615875681363361 0.837181840611857 GO:0030552 cAMP binding 1/728 24/18639 0.0416666666666667 1.06679258241758 0.615875681363361 0.837181840611857 GO:0070840 dynein complex binding 1/728 24/18639 0.0416666666666667 1.06679258241758 0.615875681363361 0.837181840611857 GO:0140033 acetylation-dependent protein binding 1/728 24/18639 0.0416666666666667 1.06679258241758 0.615875681363361 0.837181840611857 GO:0015101 organic cation transmembrane transporter activity 3/728 81/18639 0.037037037037037 0.948260073260073 0.617902405347535 0.837181840611857 GO:0005544 calcium-dependent phospholipid binding 2/728 53/18639 0.0377358490566038 0.966151772755546 0.618584476908045 0.837181840611857 GO:0008146 sulfotransferase activity 2/728 53/18639 0.0377358490566038 0.966151772755546 0.618584476908045 0.837181840611857 GO:0016860 intramolecular oxidoreductase activity 2/728 53/18639 0.0377358490566038 0.966151772755546 0.618584476908045 0.837181840611857 GO:0017046 peptide hormone binding 2/728 53/18639 0.0377358490566038 0.966151772755546 0.618584476908045 0.837181840611857 GO:0004676 3-phosphoinositide-dependent protein kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0004711 ribosomal protein S6 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0035175 histone H3S10 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0035979 histone H2AXS139 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0044022 histone H3S28 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0044023 histone H4S1 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0044024 histone H2AS1 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0044025 histone H2BS14 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0072354 histone H3T3 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0072371 histone H2AS121 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0072518 Rho-dependent protein serine/threonine kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0140823 histone H2BS36 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0140855 histone H3S57 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0140995 histone H2A kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0140997 histone H4 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0140998 histone H2B kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:1990244 histone H2AT120 kinase activity 9/728 245/18639 0.036734693877551 0.940519174702848 0.621726887936223 0.837181840611857 GO:0015081 sodium ion transmembrane transporter activity 6/728 164/18639 0.0365853658536585 0.936695926025194 0.622154091831313 0.837181840611857 GO:0004677 DNA-dependent protein kinase activity 9/728 246/18639 0.0365853658536585 0.936695926025194 0.626567199507934 0.837181840611857 GO:0140857 histone H3T45 kinase activity 9/728 246/18639 0.0365853658536585 0.936695926025194 0.626567199507934 0.837181840611857 GO:0016791 phosphatase activity 10/728 273/18639 0.0366300366300366 0.937839632894578 0.627026592706296 0.837181840611857 GO:0015485 cholesterol binding 2/728 54/18639 0.037037037037037 0.948260073260073 0.62878315777799 0.837181840611857 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/728 54/18639 0.037037037037037 0.948260073260073 0.62878315777799 0.837181840611857 GO:0051287 NAD binding 2/728 54/18639 0.037037037037037 0.948260073260073 0.62878315777799 0.837181840611857 GO:0008139 nuclear localization sequence binding 1/728 25/18639 0.04 1.02412087912088 0.630898109725836 0.837181840611857 GO:0015271 outward rectifier potassium channel activity 1/728 25/18639 0.04 1.02412087912088 0.630898109725836 0.837181840611857 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/728 25/18639 0.04 1.02412087912088 0.630898109725836 0.837181840611857 GO:0017056 structural constituent of nuclear pore 1/728 25/18639 0.04 1.02412087912088 0.630898109725836 0.837181840611857 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/728 25/18639 0.04 1.02412087912088 0.630898109725836 0.837181840611857 GO:0019707 protein-cysteine S-acyltransferase activity 1/728 25/18639 0.04 1.02412087912088 0.630898109725836 0.837181840611857 GO:0120020 cholesterol transfer activity 1/728 25/18639 0.04 1.02412087912088 0.630898109725836 0.837181840611857 GO:0035402 histone H3T11 kinase activity 9/728 247/18639 0.0364372469635627 0.932903634826712 0.631374638128108 0.837181840611857 GO:0035403 histone H3T6 kinase activity 9/728 247/18639 0.0364372469635627 0.932903634826712 0.631374638128108 0.837181840611857 GO:0004679 AMP-activated protein kinase activity 9/728 248/18639 0.0362903225806452 0.929141926621765 0.636148766795882 0.841739755762818 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 6/728 167/18639 0.0359281437125748 0.919869053102586 0.639625142654263 0.841739755762818 GO:0008017 microtubule binding 10/728 276/18639 0.036231884057971 0.927645723841376 0.640645204680311 0.841739755762818 GO:0004860 protein kinase inhibitor activity 3/728 84/18639 0.0357142857142857 0.914393642072214 0.64245886237714 0.841739755762818 GO:0051117 ATPase binding 3/728 84/18639 0.0357142857142857 0.914393642072214 0.64245886237714 0.841739755762818 GO:0001637 G protein-coupled chemoattractant receptor activity 1/728 26/18639 0.0384615384615385 0.984731614539307 0.645333812751493 0.841739755762818 GO:0004435 phosphatidylinositol phospholipase C activity 1/728 26/18639 0.0384615384615385 0.984731614539307 0.645333812751493 0.841739755762818 GO:0004529 DNA exonuclease activity 1/728 26/18639 0.0384615384615385 0.984731614539307 0.645333812751493 0.841739755762818 GO:0004950 chemokine receptor activity 1/728 26/18639 0.0384615384615385 0.984731614539307 0.645333812751493 0.841739755762818 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/728 26/18639 0.0384615384615385 0.984731614539307 0.645333812751493 0.841739755762818 GO:0008157 protein phosphatase 1 binding 1/728 26/18639 0.0384615384615385 0.984731614539307 0.645333812751493 0.841739755762818 GO:0030507 spectrin binding 1/728 26/18639 0.0384615384615385 0.984731614539307 0.645333812751493 0.841739755762818 GO:0004601 peroxidase activity 2/728 57/18639 0.0350877192982456 0.898351648351648 0.658102892994983 0.856342961615217 GO:0005385 zinc ion transmembrane transporter activity 1/728 27/18639 0.037037037037037 0.948260073260073 0.659205675660047 0.856342961615217 GO:0008395 steroid hydroxylase activity 1/728 27/18639 0.037037037037037 0.948260073260073 0.659205675660047 0.856342961615217 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/728 58/18639 0.0344827586206897 0.882862826828344 0.667455131531857 0.865460764449688 GO:0031267 small GTPase binding 10/728 283/18639 0.0353356890459364 0.90470042325166 0.671347651711183 0.865460764449688 GO:0046625 sphingolipid binding 1/728 28/18639 0.0357142857142857 0.914393642072214 0.67253569221493 0.865460764449688 GO:0050698 proteoglycan sulfotransferase activity 1/728 28/18639 0.0357142857142857 0.914393642072214 0.67253569221493 0.865460764449688 GO:0051393 alpha-actinin binding 1/728 28/18639 0.0357142857142857 0.914393642072214 0.67253569221493 0.865460764449688 GO:0051959 dynein light intermediate chain binding 1/728 28/18639 0.0357142857142857 0.914393642072214 0.67253569221493 0.865460764449688 GO:0141052 histone H3 demethylase activity 1/728 28/18639 0.0357142857142857 0.914393642072214 0.67253569221493 0.865460764449688 GO:0016651 oxidoreductase activity, acting on NAD(P)H 3/728 88/18639 0.0340909090909091 0.872830294705295 0.673436657337413 0.865460764449688 GO:0003727 single-stranded RNA binding 3/728 89/18639 0.0337078651685393 0.863023212742314 0.680864987918948 0.869374858722662 GO:0022853 active monoatomic ion transmembrane transporter activity 4/728 118/18639 0.0338983050847458 0.86789905010244 0.681767362150787 0.869374858722662 GO:0004181 metallocarboxypeptidase activity 1/728 29/18639 0.0344827586206897 0.882862826828344 0.685344999402482 0.869374858722662 GO:0004629 phospholipase C activity 1/728 29/18639 0.0344827586206897 0.882862826828344 0.685344999402482 0.869374858722662 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/728 29/18639 0.0344827586206897 0.882862826828344 0.685344999402482 0.869374858722662 GO:0005416 amino acid:monoatomic cation symporter activity 1/728 29/18639 0.0344827586206897 0.882862826828344 0.685344999402482 0.869374858722662 GO:0016417 S-acyltransferase activity 1/728 29/18639 0.0344827586206897 0.882862826828344 0.685344999402482 0.869374858722662 GO:0097472 cyclin-dependent protein kinase activity 1/728 29/18639 0.0344827586206897 0.882862826828344 0.685344999402482 0.869374858722662 GO:0001098 basal transcription machinery binding 2/728 60/18639 0.0333333333333333 0.853434065934066 0.685538300055266 0.869374858722662 GO:0001099 basal RNA polymerase II transcription machinery binding 2/728 60/18639 0.0333333333333333 0.853434065934066 0.685538300055266 0.869374858722662 GO:0019210 kinase inhibitor activity 3/728 90/18639 0.0333333333333333 0.853434065934066 0.688167084980515 0.871557258022816 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/728 91/18639 0.032967032967033 0.84405566960512 0.69534324494398 0.875487260566396 GO:0008509 monoatomic anion transmembrane transporter activity 5/728 149/18639 0.0335570469798658 0.859161811343019 0.696250543920425 0.875487260566396 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/728 30/18639 0.0333333333333333 0.853434065934066 0.697653910763847 0.875487260566396 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/728 30/18639 0.0333333333333333 0.853434065934066 0.697653910763847 0.875487260566396 GO:0031210 phosphatidylcholine binding 1/728 30/18639 0.0333333333333333 0.853434065934066 0.697653910763847 0.875487260566396 GO:0032452 histone demethylase activity 1/728 30/18639 0.0333333333333333 0.853434065934066 0.697653910763847 0.875487260566396 GO:0051721 protein phosphatase 2A binding 1/728 30/18639 0.0333333333333333 0.853434065934066 0.697653910763847 0.875487260566396 GO:0004540 RNA nuclease activity 4/728 121/18639 0.0330578512396694 0.846380891835437 0.700619210590121 0.876580013506536 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/728 122/18639 0.0327868852459016 0.839443343541704 0.706721498221333 0.876580013506536 GO:0000510 H3-H4 histone complex chaperone activity 5/728 151/18639 0.033112582781457 0.847782184702714 0.707318586918599 0.876580013506536 GO:0140584 chromatin extrusion motor activity 5/728 151/18639 0.033112582781457 0.847782184702714 0.707318586918599 0.876580013506536 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 5/728 151/18639 0.033112582781457 0.847782184702714 0.707318586918599 0.876580013506536 GO:0140849 ATP-dependent H2AZ histone chaperone activity 5/728 151/18639 0.033112582781457 0.847782184702714 0.707318586918599 0.876580013506536 GO:0008327 methyl-CpG binding 1/728 31/18639 0.032258064516129 0.825903934774903 0.709481948431853 0.876580013506536 GO:0016411 acylglycerol O-acyltransferase activity 1/728 31/18639 0.032258064516129 0.825903934774903 0.709481948431853 0.876580013506536 GO:0047499 calcium-independent phospholipase A2 activity 1/728 31/18639 0.032258064516129 0.825903934774903 0.709481948431853 0.876580013506536 GO:0070273 phosphatidylinositol-4-phosphate binding 1/728 31/18639 0.032258064516129 0.825903934774903 0.709481948431853 0.876580013506536 GO:0072349 modified amino acid transmembrane transporter activity 1/728 31/18639 0.032258064516129 0.825903934774903 0.709481948431853 0.876580013506536 GO:0140457 protein demethylase activity 1/728 31/18639 0.032258064516129 0.825903934774903 0.709481948431853 0.876580013506536 GO:0004518 nuclease activity 7/728 209/18639 0.0334928229665072 0.857517482517482 0.712611914296969 0.877225556953496 GO:0015616 DNA translocase activity 5/728 152/18639 0.0328947368421053 0.84220467032967 0.712745765024715 0.877225556953496 GO:0140674 ATP-dependent histone chaperone activity 5/728 152/18639 0.0328947368421053 0.84220467032967 0.712745765024715 0.877225556953496 GO:0008094 ATP-dependent activity, acting on DNA 7/728 210/18639 0.0333333333333333 0.853434065934066 0.717217191326062 0.8781903032566 GO:0061775 cohesin loader activity 5/728 153/18639 0.0326797385620915 0.836700064641241 0.718101638021412 0.8781903032566 GO:0005267 potassium channel activity 4/728 124/18639 0.032258064516129 0.825903934774903 0.71865388589698 0.8781903032566 GO:0016757 glycosyltransferase activity 9/728 267/18639 0.0337078651685393 0.863023212742314 0.720071191034139 0.8781903032566 GO:0031369 translation initiation factor binding 1/728 32/18639 0.03125 0.800094436813187 0.720847873923126 0.8781903032566 GO:0047498 calcium-dependent phospholipase A2 activity 1/728 32/18639 0.03125 0.800094436813187 0.720847873923126 0.8781903032566 GO:0120015 sterol transfer activity 1/728 32/18639 0.03125 0.800094436813187 0.720847873923126 0.8781903032566 GO:0140142 nucleocytoplasmic carrier activity 1/728 32/18639 0.03125 0.800094436813187 0.720847873923126 0.8781903032566 GO:0005506 iron ion binding 5/728 154/18639 0.0324675324675325 0.831266947338376 0.723386197612733 0.880165715726519 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/728 33/18639 0.0303030303030303 0.775849150849151 0.731769717733733 0.888114954518816 GO:0042923 neuropeptide binding 1/728 33/18639 0.0303030303030303 0.775849150849151 0.731769717733733 0.888114954518816 GO:0008376 acetylgalactosaminyltransferase activity 1/728 34/18639 0.0294117647058824 0.753030058177117 0.742264807784783 0.896319767891059 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/728 34/18639 0.0294117647058824 0.753030058177117 0.742264807784783 0.896319767891059 GO:0019825 oxygen binding 1/728 34/18639 0.0294117647058824 0.753030058177117 0.742264807784783 0.896319767891059 GO:0090482 vitamin transmembrane transporter activity 1/728 34/18639 0.0294117647058824 0.753030058177117 0.742264807784783 0.896319767891059 GO:0140597 protein carrier chaperone 6/728 188/18639 0.0319148936170213 0.817117722702829 0.74765734611439 0.901692640314752 GO:0000175 3'-5'-RNA exonuclease activity 1/728 35/18639 0.0285714285714286 0.731514913657771 0.752349796762621 0.901692640314752 GO:0004623 phospholipase A2 activity 1/728 35/18639 0.0285714285714286 0.731514913657771 0.752349796762621 0.901692640314752 GO:0005154 epidermal growth factor receptor binding 1/728 35/18639 0.0285714285714286 0.731514913657771 0.752349796762621 0.901692640314752 GO:0005343 organic acid:sodium symporter activity 1/728 35/18639 0.0285714285714286 0.731514913657771 0.752349796762621 0.901692640314752 GO:0043015 gamma-tubulin binding 1/728 35/18639 0.0285714285714286 0.731514913657771 0.752349796762621 0.901692640314752 GO:0003689 DNA clamp loader activity 5/728 160/18639 0.03125 0.800094436813187 0.753600085725565 0.902064940519379 GO:0106310 protein serine kinase activity 12/728 361/18639 0.0332409972299169 0.85106998264893 0.755896164395156 0.903686572626836 GO:0002039 p53 binding 2/728 69/18639 0.0289855072463768 0.742116579073101 0.757114836531536 0.904017715261536 GO:0140104 molecular carrier activity 8/728 249/18639 0.0321285140562249 0.822587051502714 0.761095084730595 0.905394877302781 GO:0004033 aldo-keto reductase (NADPH) activity 1/728 36/18639 0.0277777777777778 0.711195054945055 0.762040688396507 0.905394877302781 GO:0005484 SNAP receptor activity 1/728 36/18639 0.0277777777777778 0.711195054945055 0.762040688396507 0.905394877302781 GO:0016409 palmitoyltransferase activity 1/728 36/18639 0.0277777777777778 0.711195054945055 0.762040688396507 0.905394877302781 GO:0016782 transferase activity, transferring sulphur-containing groups 2/728 70/18639 0.0285714285714286 0.731514913657771 0.764131268426566 0.90675651135909 GO:0015171 amino acid transmembrane transporter activity 3/728 102/18639 0.0294117647058824 0.753030058177117 0.766142858464687 0.908021165587777 GO:0004722 protein serine/threonine phosphatase activity 3/728 103/18639 0.029126213592233 0.745719086738504 0.771861895255171 0.913103058741149 GO:0140713 histone chaperone activity 5/728 164/18639 0.0304878048780488 0.780579938354329 0.772333003851888 0.913103058741149 GO:0015103 inorganic anion transmembrane transporter activity 5/728 165/18639 0.0303030303030303 0.775849150849151 0.776842435594428 0.91730472099711 GO:0042162 telomeric DNA binding 1/728 38/18639 0.0263157894736842 0.673763736263736 0.780301100320842 0.920256825931215 GO:0015399 primary active transmembrane transporter activity 5/728 166/18639 0.0301204819277108 0.771175360783794 0.781283036779171 0.920284313261355 GO:0140789 histone phosphatase activity 4/728 136/18639 0.0294117647058824 0.753030058177117 0.782747115458971 0.920878959363495 GO:0031491 nucleosome binding 2/728 74/18639 0.027027027027027 0.691973566973567 0.790461713689241 0.92536342027308 GO:0051020 GTPase binding 10/728 315/18639 0.0317460317460317 0.812794348508634 0.790665797075168 0.92536342027308 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 7/728 229/18639 0.0305676855895196 0.782625125965737 0.795199976703673 0.92536342027308 GO:0019003 GDP binding 2/728 75/18639 0.0266666666666667 0.682747252747253 0.796626048536312 0.92536342027308 GO:0140767 enzyme-substrate adaptor activity 4/728 139/18639 0.0287769784172662 0.73677761087833 0.796822433192274 0.92536342027308 GO:0015144 carbohydrate transmembrane transporter activity 1/728 40/18639 0.025 0.640075549450549 0.797162029756081 0.92536342027308 GO:0030331 nuclear estrogen receptor binding 1/728 40/18639 0.025 0.640075549450549 0.797162029756081 0.92536342027308 GO:0032451 demethylase activity 1/728 40/18639 0.025 0.640075549450549 0.797162029756081 0.92536342027308 GO:0050997 quaternary ammonium group binding 1/728 40/18639 0.025 0.640075549450549 0.797162029756081 0.92536342027308 GO:0071855 neuropeptide receptor binding 1/728 40/18639 0.025 0.640075549450549 0.797162029756081 0.92536342027308 GO:0140662 ATP-dependent protein folding chaperone 1/728 40/18639 0.025 0.640075549450549 0.797162029756081 0.92536342027308 GO:0005085 guanyl-nucleotide exchange factor activity 7/728 230/18639 0.0304347826086957 0.779222408026756 0.798808521778979 0.926154807859686 GO:0008227 G protein-coupled amine receptor activity 1/728 41/18639 0.024390243902439 0.624463950683463 0.805101491143122 0.931201724695659 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/728 41/18639 0.024390243902439 0.624463950683463 0.805101491143122 0.931201724695659 GO:0019894 kinesin binding 1/728 42/18639 0.0238095238095238 0.609595761381476 0.812730597200107 0.935548718440818 GO:0031492 nucleosomal DNA binding 1/728 42/18639 0.0238095238095238 0.609595761381476 0.812730597200107 0.935548718440818 GO:0035198 miRNA binding 1/728 42/18639 0.0238095238095238 0.609595761381476 0.812730597200107 0.935548718440818 GO:0008168 methyltransferase activity 6/728 204/18639 0.0294117647058824 0.753030058177117 0.812757949145461 0.935548718440818 GO:0004721 phosphoprotein phosphatase activity 5/728 175/18639 0.0285714285714286 0.731514913657771 0.818221807763565 0.940572288172657 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/728 43/18639 0.0232558139534884 0.595419115767953 0.820061463750535 0.940572288172657 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/728 43/18639 0.0232558139534884 0.595419115767953 0.820061463750535 0.940572288172657 GO:0005319 lipid transporter activity 5/728 178/18639 0.0280898876404494 0.719186010618595 0.829362670072371 0.942230592436915 GO:0033192 calmodulin-dependent protein phosphatase activity 2/728 81/18639 0.0246913580246914 0.632173382173382 0.830340709585032 0.942230592436915 GO:0140791 histone H2AXS140 phosphatase activity 2/728 81/18639 0.0246913580246914 0.632173382173382 0.830340709585032 0.942230592436915 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/728 81/18639 0.0246913580246914 0.632173382173382 0.830340709585032 0.942230592436915 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/728 81/18639 0.0246913580246914 0.632173382173382 0.830340709585032 0.942230592436915 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/728 81/18639 0.0246913580246914 0.632173382173382 0.830340709585032 0.942230592436915 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/728 81/18639 0.0246913580246914 0.632173382173382 0.830340709585032 0.942230592436915 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/728 81/18639 0.0246913580246914 0.632173382173382 0.830340709585032 0.942230592436915 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/728 81/18639 0.0246913580246914 0.632173382173382 0.830340709585032 0.942230592436915 GO:0140303 intramembrane lipid transporter activity 1/728 45/18639 0.0222222222222222 0.568956043956044 0.833874598226362 0.942592065138148 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/728 82/18639 0.024390243902439 0.624463950683463 0.83544389936998 0.942592065138148 GO:0033549 MAP kinase phosphatase activity 2/728 82/18639 0.024390243902439 0.624463950683463 0.83544389936998 0.942592065138148 GO:0009055 electron transfer activity 3/728 116/18639 0.0258620689655172 0.662147120121258 0.836242643030536 0.942592065138148 GO:0005216 monoatomic ion channel activity 14/728 448/18639 0.03125 0.800094436813187 0.838370305216398 0.942592065138148 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/728 46/18639 0.0217391304347826 0.556587434304826 0.840378808858351 0.942592065138148 GO:0030276 clathrin binding 1/728 46/18639 0.0217391304347826 0.556587434304826 0.840378808858351 0.942592065138148 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/728 83/18639 0.0240963855421687 0.616940288627036 0.84040797609757 0.942592065138148 GO:0008135 translation factor activity, RNA binding 2/728 83/18639 0.0240963855421687 0.616940288627036 0.84040797609757 0.942592065138148 GO:1990782 protein tyrosine kinase binding 3/728 117/18639 0.0256410256410256 0.656487743026204 0.840477924748182 0.942592065138148 GO:0046873 metal ion transmembrane transporter activity 14/728 450/18639 0.0311111111111111 0.796538461538462 0.842860139689516 0.943976250940309 GO:0017018 myosin phosphatase activity 2/728 84/18639 0.0238095238095238 0.609595761381476 0.845236003261483 0.943976250940309 GO:0180051 translation factor activity 2/728 84/18639 0.0238095238095238 0.609595761381476 0.845236003261483 0.943976250940309 GO:0061749 forked DNA-dependent helicase activity 1/728 47/18639 0.0212765957446809 0.544745148468553 0.84662870006209 0.943976250940309 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/728 47/18639 0.0212765957446809 0.544745148468553 0.84662870006209 0.943976250940309 GO:0016741 transferase activity, transferring one-carbon groups 6/728 215/18639 0.027906976744186 0.714502938921544 0.849324642178799 0.945183411847208 GO:0009378 four-way junction helicase activity 1/728 48/18639 0.0208333333333333 0.533396291208791 0.852634202770502 0.945183411847208 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/728 48/18639 0.0208333333333333 0.533396291208791 0.852634202770502 0.945183411847208 GO:0036121 double-stranded DNA helicase activity 1/728 48/18639 0.0208333333333333 0.533396291208791 0.852634202770502 0.945183411847208 GO:0043138 3'-5' DNA helicase activity 1/728 48/18639 0.0208333333333333 0.533396291208791 0.852634202770502 0.945183411847208 GO:0015276 ligand-gated monoatomic ion channel activity 5/728 186/18639 0.0268817204301075 0.688253278979086 0.856374609043646 0.948234861224799 GO:0019001 guanyl nucleotide binding 12/728 400/18639 0.03 0.768090659340659 0.861037915179246 0.95120414104957 GO:0032561 guanyl ribonucleotide binding 12/728 400/18639 0.03 0.768090659340659 0.861037915179246 0.95120414104957 GO:0022834 ligand-gated channel activity 5/728 188/18639 0.0265957446808511 0.680931435585691 0.86254207972095 0.951770570726566 GO:0005048 signal sequence binding 1/728 51/18639 0.0196078431372549 0.502020038784745 0.869277969960561 0.957003269681352 GO:0030544 Hsp70 protein binding 1/728 51/18639 0.0196078431372549 0.502020038784745 0.869277969960561 0.957003269681352 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/728 52/18639 0.0192307692307692 0.492365807269654 0.874397705159007 0.961536995363857 GO:0005525 GTP binding 11/728 378/18639 0.0291005291005291 0.745061486132915 0.877066793490858 0.962536491111713 GO:0004864 protein phosphatase inhibitor activity 1/728 53/18639 0.0188679245283019 0.483075886377773 0.879317190317679 0.962536491111713 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/728 53/18639 0.0188679245283019 0.483075886377773 0.879317190317679 0.962536491111713 GO:0051018 protein kinase A binding 1/728 53/18639 0.0188679245283019 0.483075886377773 0.879317190317679 0.962536491111713 GO:0140463 chromatin-protein adaptor activity 1/728 54/18639 0.0185185185185185 0.474130036630037 0.884044247535409 0.966608744457851 GO:0016798 hydrolase activity, acting on glycosyl bonds 3/728 130/18639 0.0230769230769231 0.590838968723584 0.887446435070841 0.968266671986899 GO:0016758 hexosyltransferase activity 5/728 197/18639 0.0253807106598985 0.649822892843197 0.887607272521425 0.968266671986899 GO:0008374 O-acyltransferase activity 1/728 55/18639 0.0181818181818182 0.46550949050949 0.88858639377131 0.968266671986899 GO:0019212 phosphatase inhibitor activity 1/728 56/18639 0.0178571428571429 0.457196821036107 0.892950852732486 0.970818594137244 GO:0030170 pyridoxal phosphate binding 1/728 56/18639 0.0178571428571429 0.457196821036107 0.892950852732486 0.970818594137244 GO:0070279 vitamin B6 binding 1/728 57/18639 0.0175438596491228 0.449175824175824 0.897144566299227 0.972925160474338 GO:0005249 voltage-gated potassium channel activity 2/728 98/18639 0.0204081632653061 0.522510652612693 0.90018183978227 0.972925160474338 GO:0042626 ATPase-coupled transmembrane transporter activity 2/728 98/18639 0.0204081632653061 0.522510652612693 0.90018183978227 0.972925160474338 GO:0008408 3'-5' exonuclease activity 1/728 58/18639 0.0172413793103448 0.441431413414172 0.901174205505672 0.972925160474338 GO:0017116 single-stranded DNA helicase activity 1/728 58/18639 0.0172413793103448 0.441431413414172 0.901174205505672 0.972925160474338 GO:0061980 regulatory RNA binding 1/728 58/18639 0.0172413793103448 0.441431413414172 0.901174205505672 0.972925160474338 GO:0016779 nucleotidyltransferase activity 3/728 136/18639 0.0220588235294118 0.564772543632838 0.904628881277532 0.972925160474338 GO:0099094 ligand-gated monoatomic cation channel activity 3/728 136/18639 0.0220588235294118 0.564772543632838 0.904628881277532 0.972925160474338 GO:0015459 potassium channel regulator activity 1/728 59/18639 0.0169491525423729 0.43394952505122 0.905046181093201 0.972925160474338 GO:0070063 RNA polymerase binding 1/728 59/18639 0.0169491525423729 0.43394952505122 0.905046181093201 0.972925160474338 GO:0043130 ubiquitin binding 2/728 100/18639 0.02 0.51206043956044 0.906353706736316 0.972925160474338 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/728 60/18639 0.0166666666666667 0.426717032967033 0.908766653653166 0.972925160474338 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/728 60/18639 0.0166666666666667 0.426717032967033 0.908766653653166 0.972925160474338 GO:0005244 voltage-gated monoatomic ion channel activity 4/728 173/18639 0.023121387283237 0.591977386775075 0.910090410527037 0.972925160474338 GO:0140030 modification-dependent protein binding 4/728 173/18639 0.023121387283237 0.591977386775075 0.910090410527037 0.972925160474338 GO:0022832 voltage-gated channel activity 4/728 175/18639 0.0228571428571429 0.585211930926217 0.914544052663051 0.976598765913825 GO:1901682 sulfur compound transmembrane transporter activity 1/728 63/18639 0.0158730158730159 0.406397174254317 0.919077108898594 0.979991786676691 GO:0005261 monoatomic cation channel activity 9/728 341/18639 0.0263929618768328 0.675739582997647 0.920093881901181 0.979991786676691 GO:0004536 DNA nuclease activity 1/728 64/18639 0.015625 0.400047218406593 0.922248505578279 0.979991786676691 GO:0004497 monooxygenase activity 2/728 106/18639 0.0188679245283019 0.483075886377773 0.922793555656062 0.979991786676691 GO:0042393 histone binding 6/728 247/18639 0.0242914979757085 0.621935756551141 0.923795116224979 0.979991786676691 GO:0019903 protein phosphatase binding 3/728 144/18639 0.0208333333333333 0.533396291208791 0.923846423898339 0.979991786676691 GO:0120013 lipid transfer activity 1/728 65/18639 0.0153846153846154 0.393892645815723 0.925295778145655 0.98044585763778 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4/728 181/18639 0.0220994475138122 0.565812640398276 0.926746928137946 0.980900828018113 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/728 67/18639 0.0149253731343284 0.382134656388388 0.93103716806439 0.981808116958465 GO:0022836 gated channel activity 8/728 318/18639 0.0251572327044025 0.644101181837031 0.932845470354567 0.981808116958465 GO:0003777 microtubule motor activity 1/728 68/18639 0.0147058823529412 0.376515029088559 0.93374042789904 0.981808116958465 GO:0005548 phospholipid transporter activity 1/728 68/18639 0.0147058823529412 0.376515029088559 0.93374042789904 0.981808116958465 GO:0030145 manganese ion binding 1/728 68/18639 0.0147058823529412 0.376515029088559 0.93374042789904 0.981808116958465 GO:0140223 general transcription initiation factor activity 1/728 68/18639 0.0147058823529412 0.376515029088559 0.93374042789904 0.981808116958465 GO:0061630 ubiquitin protein ligase activity 9/728 353/18639 0.0254957507082153 0.652768265728606 0.936729117442511 0.983015628506345 GO:0016887 ATP hydrolysis activity 11/728 417/18639 0.026378896882494 0.675379476638469 0.937742617424448 0.983015628506345 GO:0008028 monocarboxylic acid transmembrane transporter activity 1/728 70/18639 0.0142857142857143 0.365757456828885 0.93883361081461 0.983015628506345 GO:0046943 carboxylic acid transmembrane transporter activity 4/728 188/18639 0.0212765957446809 0.544745148468553 0.938984720146165 0.983015628506345 GO:0005342 organic acid transmembrane transporter activity 4/728 189/18639 0.0211640211640212 0.541862899005756 0.940572679122174 0.983605416075476 GO:0004521 RNA endonuclease activity 1/728 73/18639 0.0136986301369863 0.350726328466055 0.945749716585615 0.986830824016677 GO:0003730 mRNA 3'-UTR binding 6/728 262/18639 0.0229007633587786 0.58632874758829 0.945874472396008 0.986830824016677 GO:0003678 DNA helicase activity 1/728 74/18639 0.0135135135135135 0.345986783486784 0.947876949502004 0.986830824016677 GO:0003684 damaged DNA binding 1/728 74/18639 0.0135135135135135 0.345986783486784 0.947876949502004 0.986830824016677 GO:0000287 magnesium ion binding 5/728 230/18639 0.0217391304347826 0.556587434304826 0.948796719341034 0.986830824016677 GO:0032182 ubiquitin-like protein binding 2/728 120/18639 0.0166666666666667 0.426717032967033 0.951194557236032 0.988254085440033 GO:0140097 catalytic activity, acting on DNA 8/728 336/18639 0.0238095238095238 0.609595761381476 0.95393874409146 0.989095463581522 GO:0008514 organic anion transmembrane transporter activity 6/728 269/18639 0.0223048327137546 0.571071122186364 0.954064999246343 0.989095463581522 GO:0016829 lyase activity 4/728 200/18639 0.02 0.51206043956044 0.95571435182569 0.989272108228982 GO:0061659 ubiquitin-like protein ligase activity 9/728 372/18639 0.0241935483870968 0.619427951081177 0.956922669195713 0.989272108228982 GO:0015370 solute:sodium symporter activity 1/728 79/18639 0.0126582278481013 0.324088885797747 0.957326863067422 0.989272108228982 GO:0000049 tRNA binding 1/728 80/18639 0.0125 0.320037774725275 0.959000680076415 0.989936185885332 GO:0030971 receptor tyrosine kinase binding 1/728 81/18639 0.0123456790123457 0.316086691086691 0.960608929707557 0.990531227195763 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2/728 130/18639 0.0153846153846154 0.393892645815723 0.96504323194619 0.99311579051781 GO:0005262 calcium channel activity 2/728 131/18639 0.0152671755725191 0.390885831725526 0.966199094389673 0.99311579051781 GO:0004842 ubiquitin-protein transferase activity 11/728 449/18639 0.0244988864142539 0.627245527301207 0.966218904524619 0.99311579051781 GO:0052689 carboxylic ester hydrolase activity 1/728 92/18639 0.0108695652173913 0.278293717152413 0.974638957093762 0.999973656843306 GO:0022843 voltage-gated monoatomic cation channel activity 2/728 143/18639 0.013986013986014 0.358084223468839 0.977494842125473 0.999973656843306 GO:0015085 calcium ion transmembrane transporter activity 2/728 147/18639 0.0136054421768707 0.348340435075129 0.980372818365892 0.999973656843306 GO:0019787 ubiquitin-like protein transferase activity 11/728 479/18639 0.022964509394572 0.58796083874372 0.981682337031313 0.999973656843306 GO:0022804 active transmembrane transporter activity 10/728 457/18639 0.0218818380743982 0.560241181138336 0.98574748685225 0.999973656843306 GO:0004843 cysteine-type deubiquitinase activity 1/728 108/18639 0.00925925925925926 0.237065018315018 0.986639991394425 0.999973656843306 GO:0016755 aminoacyltransferase activity 11/728 496/18639 0.0221774193548387 0.567808955157746 0.987247604037496 0.999973656843306 GO:0015291 secondary active transmembrane transporter activity 5/728 287/18639 0.0174216027874564 0.446045679059616 0.988584617698828 0.999973656843306 GO:0101005 deubiquitinase activity 1/728 115/18639 0.00869565217391304 0.22263497372193 0.989908703696605 0.999973656843306 GO:0015294 solute:monoatomic cation symporter activity 1/728 116/18639 0.00862068965517241 0.220715706707086 0.990305295345756 0.999973656843306 GO:0008528 G protein-coupled peptide receptor activity 1/728 122/18639 0.00819672131147541 0.209860835885426 0.992378504705157 0.999973656843306 GO:0004519 endonuclease activity 1/728 127/18639 0.0078740157480315 0.201598598252142 0.99376358325857 0.999973656843306 GO:0019783 ubiquitin-like protein peptidase activity 1/728 127/18639 0.0078740157480315 0.201598598252142 0.99376358325857 0.999973656843306 GO:0001653 peptide receptor activity 1/728 128/18639 0.0078125 0.200023609203297 0.994008835602334 0.999973656843306 GO:0140098 catalytic activity, acting on RNA 7/728 387/18639 0.0180878552971576 0.463103756708408 0.994076986575011 0.999973656843306 GO:0035591 signaling adaptor activity 1/728 129/18639 0.00775193798449612 0.198473038589318 0.994244455918984 0.999973656843306 GO:0015078 proton transmembrane transporter activity 2/728 185/18639 0.0108108108108108 0.276789426789427 0.994786513731946 0.999973656843306 GO:0015297 antiporter activity 1/728 135/18639 0.00740740740740741 0.189652014652015 0.995476057295576 0.999973656843306 GO:0140101 catalytic activity, acting on a tRNA 1/728 139/18639 0.00719424460431655 0.184194402719583 0.996147124148016 0.999973656843306 GO:0015293 symporter activity 1/728 146/18639 0.00684931506849315 0.175363164233027 0.997091179987662 0.999973656843306 GO:0003774 cytoskeletal motor activity 1/728 153/18639 0.0065359477124183 0.167340012928248 0.997804155763575 0.999973656843306 GO:0016874 ligase activity 1/728 167/18639 0.00598802395209581 0.153311508850431 0.998749080726059 0.999973656843306 GO:0003735 structural constituent of ribosome 1/728 175/18639 0.00571428571428571 0.146302982731554 0.999093217481755 0.999973656843306 GO:0043021 ribonucleoprotein complex binding 1/728 177/18639 0.00564971751412429 0.14464984168374 0.999163315062611 0.999973656843306 GO:0045182 translation regulator activity 3/728 356/18639 0.00842696629213483 0.215755803185578 0.99992519557432 0.999973656843306 GO:0030371 translation repressor activity 2/728 329/18639 0.0060790273556231 0.155641470991015 0.999973656843306 0.999973656843306