category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	104/782	250/9376	4.9877442455243	CTSD/LIPA/LAPTM5/CTSB/ACP5/CTSZ/LGMN/CD68/CTSS/ATP6V0B/ASAH1/HEXB/SCARB2/PSAP/NPC2/ATP6V1F/CD63/CTSL/PPT1/TCIRG1/SLC11A1/ATP6V0D1/CTSH/SLC15A3/RRAGD/GM2A/DNASE2/AP2S1/ATP6AP1/LAMP2/TPP1/BLOC1S2/LITAF/LAMP1/ATP6V0E1/ATP6V1B2/GNS/IGF2R/ARL8B/ATP6V1A/ACP2/MITF/CTSA/DMXL2/FUCA2/FUCA1/GLA/HEXA/GUSB/M6PR/CTSC/ATP6V1D/GNPTG/ATP6V1C1/SLC17A5/CLN8/OSTM1/VPS29/GLB1/NPC1/BLOC1S1/PLA2G15/CLN5/CTBS/AP1S2/MANBA/RRAGC/GAA/ARSB/SUMF1/ARL8A/MCOLN1/VAMP8/NAGLU/GALNS/CLTB/ATP6V1H/SMPD1/SORT1/LAMTOR3/SLC29A3/IDS/SLC11A2/TFEB/LAMTOR2/SNAPIN/CLCN7/GNPTAB/RAB7A/CLN6/SLC36A1/AP3S1/AP1S1/OSBPL1A/SLC15A4/NAGPA/AP5B1/NEU1/ARSA/AGA/VPS18/OSBP/VPS41/FIG4	19.2773977913151
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	53/782	155/9376	4.09972774523554	HLA-B/OLR1/CTSS/ITGB2/ATP6V0B/MSR1/CD36/NCF2/ATP6V1F/CTSL/HLA-A/FCGR3A/TCIRG1/ATP6V0D1/CYBA/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/ATP6AP1/LAMP2/LAMP1/ATP6V0E1/ATP6V1B2/HLA-E/HLA-DPA1/HLA-DPB1/ITGB5/ATP6V1A/ITGAM/HLA-DRB1/MARCO/HLA-DQB1/HLA-DQA2/M6PR/TFRC/ATP6V1D/ATP6V1C1/TUBB6/ACTB/CALR/VAMP3/TAP1/SEC61A1/CLEC7A/ITGAV/ATP6V1H/STX7/TUBB2A/TLR2/RILP/RAB7A	11.7379357709568
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	49/782	181/9376	3.24584928855039	CTSD/CTSS/ITGB2/ATP6V0B/LSP1/FCGR3A/ITGAX/TCIRG1/ATP6V0D1/IL18/HLA-DRA/HLA-DMB/HLA-DMA/ATP6AP1/LAMP2/LAMP1/FCER1G/HLA-DPA1/STAT1/HLA-DPB1/SPHK1/ITGAM/IL10RB/HLA-DRB1/RHOA/CD74/HLA-DQB1/HLA-DQA2/MAPK13/CEBPB/TRADD/CLEC7A/IL10RA/ATP6V1H/IFNGR2/IFNGR1/PLK3/RIPK2/CALM3/IL10/TLR2/RAB7A/CYCS/CASP8/TLR1/MAPK1/CARD9/VDR/IRAK1	9.20312603306796
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	31/782	95/9376	3.91245120473819	ACP5/ITGB2/ATP6V0B/ATP6V1F/CTSL/TCIRG1/ATP6V0D1/IL18/HLA-DRA/HLA-DMB/HLA-DMA/ATP6AP1/TNFSF13B/ATP6V0E1/ATP6V1B2/HLA-DPA1/HLA-DPB1/ATP6V1A/CXCL2/HLA-DRB1/HLA-DQB1/ICAM1/HLA-DQA2/CD86/ATP6V1D/ATP6V1C1/CXCL3/CCL20/ATP6V1H/TLR2/CSF1	8.60625904987037
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	43/782	180/9376	2.8642227905655	HLA-B/B2M/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/HLA-E/HLA-DPA1/STAT1/HLA-DPB1/TAPBP/HLA-DRB1/CD74/HLA-DQB1/HLA-DQA2/TNFRSF14/BST2/PILRA/IFNAR1/CALR/TAP1/TRADD/STAT2/BIRC3/IFNGR2/IFIH1/OAS1/IFNGR1/TAPBPL/OAS2/NFKBIA/BAK1/SP100/TLR2/CYCS/CASP8/ZC3HAV1/TNFSF14/CARD9/IKBKG/IRAK1	7.61773611650453
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	27/782	82/9376	3.94785103861269	CTSB/LGMN/HLA-B/CTSS/B2M/CTSL/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/IFI30/HLA-E/HLA-DPA1/HLA-DPB1/TAPBP/HLA-DRB1/CD74/HLA-DQB1/PSME2/HLA-DQA2/CD4/CALR/TAP1/HSPA1A/TAPBPL	8.08727974733391
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	51/782	248/9376	2.4656381486676	ANXA2/S100A10/FLNA/IL18/ARPC2/AHNAK/ARL8B/ARPC1B/LY96/RHOA/ARPC4/ARPC5/M6PR/MAPK13/TUBB6/ACTB/ACTR3/RRAS/TRADD/PLEKHM2/CASP4/MYL12A/PTPRC/ARL8A/RAB9A/CASP1/STX10/RALA/PYCARD/BIRC3/ABI1/RIPK2/TUBB2A/NFKBIA/SNX9/RHOG/BAK1/TLR2/RILP/RAB7A/CYCS/CASP8/PFN1/MAPK1/IKBKG/VPS18/ARF6/VPS41/DYNLT3/IRAK1/RHOB	7.05596024742755
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	36/782	157/9376	2.74924658315278	LIPA/CD36/HAVCR2/LRP1/SGK1/NR1H3/SPHK1/ITGB5/SIRPA/DUSP2/ALOX5/ADAM9/ABCA1/PTGER4/MAPK13/CEBPB/CALR/TMEM30A/PLA2G15/ITGAV/CASP1/PTPN6/MERTK/CPT1A/ATP2A2/IL10/ADAM17/RAB7A/RXRA/ADAM10/HIF1A/MAPK1/CD47/VPS18/SIRPB1/VPS41	6.6673045454092
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	29/782	112/9376	3.10449397150164	HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/STAT1/HLA-DPB1/IL10RB/LY96/HLA-DRB1/HLA-DQB1/ALOX5/HLA-DQA2/MAPK13/CD40/IL10RA/HSPA1A/BIRC3/IFNGR2/ITGA6/IFNGR1/NFKBIA/IL10/TLR2/PPIF/CYCS/CASP8/MAPK1/IKBKG/IRAK1	6.75847581794888
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	22/782	70/9376	3.76821337230544	HLA-B/ITGB2/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/ICAM1/HLA-DQA2/CD86/ACTB/CD40/CYCS/CASP8/SNTB2/SNTB1	7.01226626081237
Human Diseases	Immune disease	hsa05330	Allograft rejection	16/782	39/9376	4.91887992655256	HLA-B/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/CD86/CD40/IL10	7.39744800319764
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	23/782	78/9376	3.53544494720965	ITGB2/NCF2/FCGR3A/CYBA/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/STAT1/HLA-DPB1/ITGAM/HLA-DRB1/HLA-DQB1/HLA-DQA2/MAPK13/PTPN6/IFNGR2/IFNGR1/NFKBIA/IL10/TLR2/MAPK1/IRAK1	6.78262889189252
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	18/782	52/9376	4.15030493802872	APOE/APOC1/LIPA/LPL/TSPO/NCEH1/CD36/NPC2/CYP27A1/LRP1/SOAT1/PLTP/ABCA1/NPC1/SORT1/LRPAP1/APOC2/STARD3	6.87138802020111
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	41/782	205/9376	2.39795396419437	VIM/HLA-B/B2M/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/CD44/HLA-DMA/HLA-E/HLA-DPA1/STAT1/CD58/HLA-DPB1/TAPBP/HLA-DRB1/HLA-DQB1/ICAM1/HLA-DQA2/MAPK13/IFNAR1/CALR/TAP1/TRADD/CD40/STAT2/OAS1/RELB/TAPBPL/OAS2/NFKBIA/BAK1/NFKBIE/TLR2/CYCS/GADD45B/CASP8/GADD45G/IKBKG/IRAK1	6.1045378919459
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	21/782	76/9376	3.3129627136896	LPL/OLR1/FABP5/CD36/DBI/CYP27A1/PLIN2/NR1H3/PLTP/FABP3/ACSL1/PCK2/FABP4/SCP2/SLC27A1/ME3/CPT1A/ACOX2/CPT2/RXRA/ACSL4	6.10696306895086
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	35/782	174/9376	2.41173530881618	BCAP31/SSR3/SIL1/TRAM1/P4HB/CAPN2/MAN1A1/CALR/RPN1/BCAP29/CKAP4/UBE2D1/SEC61A1/SEL1L/DNAJC1/CAPN1/HSPA1A/DERL1/UBE2J1/DNAJC5/FBXO6/AMFR/EDEM2/BAK1/MAGT1/DERL2/HYOU1/PREB/SAR1A/SAR1B/UGGT1/HERPUD1/PDIA4/NFE2L2/LMAN2	5.66993560723846
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/782	51/9376	3.76149641442255	ATP6V0B/ATP6V1F/TCIRG1/ATP6V0D1/ATP6AP1/ATP6V0E1/ATP6V1B2/ATP6V1A/ATP6V1D/ATP6V1C1/ACTB/ADCY3/SEC61A1/ATP6V1H/PDIA4/PRKACB	5.96480831197382
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	37/782	200/9376	2.2181074168798	IL18/ARPC2/ARPC1B/TMBIM6/RHOA/ARPC4/ARPC5/MAPK13/MYO1E/TMED10/TUBB6/ACTB/ACTR3/RAB1A/TRADD/CASP4/GNA12/CASP1/PTPN6/PYCARD/ARHGEF2/ABI1/HCLS1/TUBB2A/NFKBIA/MYO1C/GNA13/WIPF1/BAK1/NCK1/CYCS/CASP8/MYO5A/MAPK1/IKBKG/ARF6/IRAK1	5.25248986402152
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	19/782	71/9376	3.20852995209106	ATP6V0B/ATP6V1F/TCIRG1/ATP6V0D1/ATP6AP1/ATP6V0E1/ATP6V1B2/ATP6V1A/CXCL2/MAPK13/ATP6V1D/ATP6V1C1/CXCL3/ATP6V1H/NFKBIA/HBEGF/ADAM17/ADAM10/IKBKG	5.63463280248539
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	14/782	42/9376	3.99658994032396	FTH1/FTL/HMOX1/SAT1/SLC39A8/ACSL1/TFRC/ATG7/PRNP/SLC3A2/STEAP3/SLC11A2/GPX4/ACSL4	5.87096382254293
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	16/782	54/9376	3.55252439139907	HLA-B/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/CD86/CD40/IL10	5.67418604698884
Human Diseases	Immune disease	hsa05310	Asthma	12/782	32/9376	4.49616368286445	HLA-DRA/HLA-DMB/HLA-DMA/FCER1G/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/CD40/PRG2/IL10	5.97573969886858
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	16/782	55/9376	3.48793303882818	ASAH1/HEXB/PSAP/GM2A/SPHK1/GLA/HEXA/SGPL1/GLB1/DEGS1/UGCG/SGMS2/SMPD1/ACER3/NEU1/ARSA	5.5818751480013
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	31/782	160/9376	2.3230179028133	HLA-B/ITGB2/ALCAM/HLA-A/HLA-C/HLA-F/SDC2/HLA-DRA/HLA-DMB/HLA-DMA/HLA-E/HLA-DPA1/CD58/HLA-DPB1/ITGAM/HLA-DRB1/HLA-DQB1/CD99/ICAM1/HLA-DQA2/CD86/CD4/CD276/CD40/PTPRC/ITGAV/SDC4/ITGA6/CADM1/ITGB7/GLG1	5.09150083535274
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/782	44/9376	3.81492676121832	HLA-B/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/CD86	5.64543502178972
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/782	19/9376	5.6793646520393	HEXB/GNS/HEXA/GUSB/GLB1/ARSB/NAGLU/GALNS/IDS	6.15866690791295
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/782	45/9376	3.73015061096903	HLA-B/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/HLA-E/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/CD86	5.53758120775404
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	28/782	142/9376	2.36417996469868	ACP5/TREM2/NCF2/TYROBP/FCGR3A/CYBA/LILRB4/STAT1/SQSTM1/SIRPA/MITF/OSCAR/SPI1/MAPK13/IFNAR1/STAT2/IFNGR2/RELB/IFNGR1/NFKBIA/ATP2A2/LILRB1/MAPK1/CSF1/IKBKG/FOSL2/SIRPB1/LILRB3	4.94097030751924
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	21/782	93/9376	2.70736737892913	HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/STAT1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/MAPK13/IL2RG/CD4/NOTCH2/IFNGR2/IFNGR1/NFKBIA/NFKBIE/MAPK1/LAT/IKBKG/MAML2	4.99132235227776
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	27/782	138/9376	2.34582453019015	IL18/ARPC2/FN1/ARPC1B/RHOA/ARPC4/ARPC5/MAPK13/SKAP2/CD4/ACTB/ACTR3/LIMK1/RPS6KA1/CASP1/PYCARD/NFKBIA/WIPF1/RHOG/IL10/MAPK1/LAT/RPS6KA2/IKBKG/GIT2/ARF6/IRAK1	4.80430249441208
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	33/782	187/9376	2.11584173311268	CTSB/CYBA/IL18/STAT1/CXCL2/RHOA/GBP1/TRPV2/MAPK13/TXNIP/IFNAR1/CXCL3/P2RX7/GABARAPL1/GBP2/CASP4/GABARAP/STAT2/CASP1/PYCARD/BIRC3/OAS1/OAS2/RIPK2/NFKBIA/GBP3/CASP8/MAPK1/CARD9/CARD16/IKBKG/GBP5/PSTPIP1	4.64922557117663
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	15/782	56/9376	3.21154548776032	ITGB2/IL18/CXCL2/ITGAM/CXCL3/RAB1A/CASP1/PYCARD/HSPA1A/NFKBIA/TLR2/CYCS/CASP8/SAR1A/SAR1B	5.00695022343455
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	14/782	50/9376	3.35713554987212	HLA-DRA/HLA-DMB/HLA-DMA/TNFSF13B/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/CXCR4/HLA-DQA2/CD86/CD40/IL10/ITGB7	5.04095934069858
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	8/782	18/9376	5.32878658709861	HEXB/FUCA2/FUCA1/HEXA/GLB1/MANBA/NEU1/AGA	5.54500889846942
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	21/782	105/9376	2.39795396419437	LSP1/MRAS/FCER1G/STAT1/RHOA/MAPK13/RRAS/CLEC7A/STAT2/CASP1/PYCARD/RELB/PLK3/NFKBIA/CALM3/IL10/NRAS/CASP8/MAPK1/CARD9/IKBKG	4.34525801198318
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/782	43/9376	3.34598227562006	ACAA2/ACSL1/ALDH2/ACAT1/CPT1A/ACADVL/ALDH3A2/CPT2/HADHB/ALDH9A1/ACADS/ACSL4	4.65092848398331
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	20/782	100/9376	2.39795396419437	CD9/CD36/ANPEP/HLA-DRA/HLA-DMB/CD44/HLA-DMA/HLA-DPA1/HLA-DPB1/ITGAM/HLA-DRB1/HLA-DQB1/HLA-DQA2/TFRC/CD4/CD37/CD59/IL7R/ITGA6/CSF1	4.23939457799286
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/782	250/9376	1.82244501278772	HLA-B/HLA-A/HLA-C/HLA-F/RAB31/ARPC2/AP2S1/HLA-E/IGF2R/ARPC1B/RHOA/ARPC4/ARPC5/CXCR4/TFRC/IL2RG/ACTR3/RAB22A/VPS29/RUFY1/AGAP3/CLTB/HSPA1A/CHMP1B/ARRB2/ASAP1/WIPF1/PDCD6IP/RAB7A/CHMP4B/ARAP1/CHMP3/SPG21/EHD4/CHMP4A/SH3GLB1/GIT2/ARF6	3.97583162229795
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/782	173/9376	2.00984580813979	IL18/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/STAT1/HLA-DPB1/HLA-DRB1/HLA-DQB1/ICAM1/HLA-DQA2/ACTB/IFNAR1/TRADD/STAT2/CASP1/PYCARD/IFNGR2/IFIH1/OAS1/IFNGR1/OAS2/NFKBIA/BAK1/CYCS/CASP8/MX2/MAPK1/IKBKG	4.0439404128522
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/782	109/9376	2.30995565358174	HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/STAT1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/MAPK13/IL2RG/CD4/IFNGR2/IFNGR1/NFKBIA/NFKBIE/RXRA/HIF1A/MAPK1/LAT/IKBKG	4.14946017827666
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	35/782	227/9376	1.84864292393839	HLA-B/B2M/HLA-A/HLA-C/HLA-F/HLA-E/TAPBP/IL10RB/RHOA/CXCR4/PTGER4/MAPK13/ADCY3/CALR/TAP1/TRADD/GNA12/ITGAV/CREB3/IL10RA/TAPBPL/NFKBIA/GNA13/BAK1/CALM3/NRAS/CYCS/CASP8/MAPK1/GNG5/GNB4/GNGT2/PRKACB/IKBKG/CCR1	3.90429342373612
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/782	66/9376	2.72494768658452	IL18/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/STAT1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/IL2RG/IFNGR2/IFNGR1/IL10/TLR2	4.24193877423667
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/782	28/9376	3.85385458531239	ATP6V1F/TCIRG1/ATP6V0D1/ATP6V0E1/ATP6V1B2/ATP6V1A/ATP6V1D/ATP6V1C1/CA2	4.56186936211254
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/782	47/9376	3.06121782663111	ME2/MDH1/ALDH2/PCK2/AKR1A1/ACAT1/PKM/HAGH/ME3/ALDH3A2/ALDH9A1/FH	4.27313498764663
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/782	137/9376	2.10039763287098	CTSD/CTSB/CTSZ/CTSS/BCL2A1/CTSL/CTSH/LMNA/CTSC/ACTB/CAPN2/TRADD/CAPN1/BIRC3/NFKBIA/BAK1/NRAS/SPTAN1/CYCS/GADD45B/CASP8/GADD45G/MAPK1/IKBKG	3.91371131221452
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	33/782	214/9376	1.848889738748	HLA-B/B2M/HLA-A/HLA-C/HLA-F/HLA-E/TAPBP/SAMHD1/CXCR4/BST2/MAPK13/CD4/CFL1/CALR/LIMK1/TAP1/TRADD/AP1S2/TAPBPL/NFKBIA/BAK1/CALM3/TLR2/NRAS/CYCS/CASP8/MAPK1/GNG5/AP1S1/GNB4/GNGT2/IKBKG/IRAK1	3.78925966436972
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	13/782	57/9376	2.73450890653744	PPT1/ACAA2/ACSL1/HSD17B4/ACAT1/SCP2/CPT1A/ACADVL/CPT2/ELOVL1/HADHB/ACADS/ACSL4	3.96205633456441
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	20/782	116/9376	2.06720169327101	FBP1/SDS/SDSL/ME2/HK3/MDH1/ACAT1/ADPGK/PGK1/SDHB/CAT/PRPS2/PGAM1/PKM/ME3/SDHD/SUCLG2/ACO2/ACADS/FH	3.4886816986725
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/782	22/9376	3.81492676121832	HNMT/ALDH2/ALDH3B1/ALDH3A2/CNDP2/AOC1/ALDH9A1	3.98722824866963
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/782	196/9376	1.7739965551438	HLA-B/HLA-A/HLA-C/HLA-F/HLA-E/STAT1/CXCL2/CLEC2B/ICAM1/MAPK13/CD86/IFNAR1/CXCL3/TRADD/STAT2/IFNGR1/NFKBIA/BAK1/CALM3/NRAS/CYCS/CASP8/HIF1A/MAPK1/GNG5/GNB4/GNGT2/IKBKG/CCR1	3.30321667995289
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/782	224/9376	1.71282426013884	HLA-B/TSPO/ITGB2/B2M/HLA-A/HLA-C/HLA-F/HLA-DRA/HLA-DMB/HLA-DMA/HLA-E/HLA-DPA1/HLA-DPB1/MMP7/HLA-DRB1/HLA-DQB1/ICAM1/HLA-DQA2/SPI1/IL2RG/CD4/ADCY3/CALR/CD40/CREB3/NRP1/RELB/NFKBIA/NRAS/MAPK1/PRKACB/IKBKG	3.25716542049047
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/782	105/9376	2.05538911216661	BCL2A1/TNFSF13B/CXCL2/LY96/ICAM1/CXCL3/TRADD/CD40/PLAU/BIRC3/RELB/NFKBIA/GADD45B/TNFSF14/GADD45G/LAT/IKBKG/IRAK1	3.28046424478977
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/782	82/9376	2.19325057700705	MGST1/GSTO1/TYMP/UPP1/MGST3/GUSB/DPYD/IMPDH1/MGST2/TK2/TK1/NME3/UCK2/RRM2B/ITPA	3.27362241121422
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	32/782	232/9376	1.65376135461681	ITGB2/RGCC/GSN/ITGAX/ARPC2/MRAS/TMSB4X/ITGB5/FN1/ARPC1B/ITGAM/RHOA/ARPC4/ARPC5/CXCR4/ACTB/ACTR3/CFL1/ACTN1/LIMK1/RRAS/MYL12A/GNA12/ITGAV/MSN/ITGA6/GNA13/NRAS/PFN1/ITGB7/MAPK1/TIAM1	3.04149053038533
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/782	99/9376	2.05884936319719	ITGB2/FCGR3A/C5AR1/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/HLA-DPB1/ITGAM/FPR3/HLA-DRB1/HLA-DQB1/ICAM1/HLA-DQA2/C2/IL10/CFD	3.19476809631618
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/782	67/9376	2.32637324884529	FBP1/GALM/HK3/ALDH2/ALDH3B1/PCK2/AKR1A1/ADPGK/PGK1/PGAM1/PKM/ALDH3A2/ALDH9A1	3.28657070946261
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/782	142/9376	1.85756997226325	MGST1/NCF2/GSTO1/CTSL/CYBA/MGST3/SDC2/MMP9/HMOX1/SQSTM1/RHOA/ICAM1/DUSP1/MAPK13/ACTB/MGST2/ITGAV/SDC4/ARHGEF2/CALM3/NFE2L2/IKBKG	3.10606216131368
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/782	38/9376	2.83968232601965	HEXB/GNPDA1/HK3/HEXA/RENBP/PMM1/CHIT1/AMDHD2/NAGK	3.427670285792
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	25/782	169/9376	1.77363458890116	CTSD/CTSB/CTSL/RRAGD/MRAS/LAMP2/LAMP1/SQSTM1/ATG7/RAB1A/GABARAPL1/RRAS/RRAGC/GABARAP/VAMP8/STX7/NRAS/RAB7A/HIF1A/MAPK1/SH3GLB1/C9orf72/PRKACB/VPS18/VPS41	3.0613395300905
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	30/782	216/9376	1.66524580846831	OLR1/CD36/NCF2/CYBA/MMP9/IL18/CXCL2/LY96/RHOA/ICAM1/ABCA1/MAPK13/CXCL3/CD40/SOD2/CASP1/PYCARD/HSPA1A/RAP1A/NFKBIA/CALM3/TLR2/NRAS/CYCS/RXRA/CASP8/MAPK1/NFE2L2/IKBKG/IRAK1	2.98368262777786
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/782	109/9376	1.97996198878435	SPP1/STAT1/LY96/MAPK13/CD86/IFNAR1/CD40/STAT2/NFKBIA/TOLLIP/TLR2/MAP3K8/CASP8/TLR1/MAPK1/IKBKG/IRAK1/IRF5	3.10416099779191
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/782	61/9376	2.35864324346988	FTH1/FTL/HMOX1/SLC31A1/SLC8A1/ATP1B3/SLC30A1/ATOX1/ATP1A1/ATP1B1/SLC11A2/VDR	3.21122148857616
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	42/782	333/9376	1.51222322066312	SPP1/HLA-B/ATP6V0B/ATP6V1F/HLA-A/TCIRG1/ATP6V0D1/HLA-C/BCAP31/HLA-F/ATP6AP1/ATP6V0E1/ATP6V1B2/HLA-E/STAT1/ITGB5/ATP6V1A/FN1/PTGER4/ATP6V1D/ATP6V1C1/IFNAR1/TRADD/LFNG/NOTCH2/ITGAV/STAT2/CREB3/ATP6V1H/UBR4/PKM/ITGA6/BAK1/NRAS/CASP8/MX2/ITGB7/MAPK1/PRKACB/IKBKG/MAML2/OASL	2.87088934779154
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/782	119/9376	1.91433299662576	MMP9/CXCL2/ICAM1/MAPK13/CEBPB/CXCL3/TRADD/CCL20/MMP14/CREB3/BIRC3/NFKBIA/ADAM17/MAP3K8/CASP8/RHBDF2/MAPK1/CSF1/IKBKG	3.02784808603501
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/782	62/9376	2.32060061051068	APH1A/LFNG/NOTCH2/APH1B/NUMB/ATXN1/PTCRA/ADAM17/TLE3/MAML2/DTX3L/PSENEN	3.14695520991678
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	21/782	138/9376	1.82453019014789	ATP6V0B/ATP6V1F/TCIRG1/ATP6V0D1/ATP6AP1/ATP6V0E1/ATP6V1B2/ATP6V1A/NDUFB9/ATP6V1D/ATP6V1C1/SDHB/UQCRQ/COX7A2/ATP6V1H/NDUFB3/SDHD/CYCS/NDUFB2/COX8A/UQCRC1	2.94339444733253
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	14/782	79/9376	2.1247693353621	ATP6V0B/ATP6V1F/TCIRG1/ATP6V0D1/SLC1A3/AP2S1/ATP6V0E1/ATP6V1B2/ATP6V1A/ATP6V1D/ATP6V1C1/NAPA/CLTB/ATP6V1H	3.02828634229295
NA	NA	hsa03272	Virion - Hepatitis viruses	10/782	48/9376	2.49786871270247	CD9/CD81/CD63/LAMP2/LAMP1/TGOLN2/CHMP1B/PDCD6IP/CHMP4B/CHMP4A	3.13827819573611
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	33/782	253/9376	1.56388302012677	RRAGD/IL18/ARPC2/CD44/ARPC1B/SQSTM1/RHOA/ARPC4/ARPC5/HK3/CAST/MAPK13/ACTB/ACTR3/CAPN2/ACTN1/TRADD/UBE2D1/CASP4/RRAGC/MYL12A/CASP1/CAPN1/PYCARD/ARHGEF2/HCLS1/RIPK2/NFKBIA/CYCS/PFN1/MAPK1/IKBKG/ARF6	2.74265878555241
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/782	42/9376	2.56923639020826	IL4I1/ALDH2/KYNU/ACAT1/CYP1B1/CAT/ALDH3A2/AOC1/ALDH9A1	3.07447140229488
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	16/782	98/9376	1.95751344015867	GSN/FCGR3A/ARPC2/SPHK1/ARPC1B/ARPC4/ARPC5/ACTR3/CFL1/LIMK1/PTPRC/ASAP1/MARCKS/MAPK1/LAT/ARF6	2.87423366926384
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/782	50/9376	2.39795396419437	CD81/ITGB2/CD36/LRP1/SDC2/IL18/ICAM1/CD40/IL10/TLR2	2.98965797450831
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/782	59/9376	2.2353808140795	GPX1/MGST1/GSTO1/ANPEP/MGST3/LAP3/MGST2/GSTK1/SMS/RRM2B/GPX4	2.87131044263582
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/782	23/9376	3.12776604025353	MDH1/PCK2/ATP1B3/ATP1A1/ATP1B1/CA2	3.08179441686659
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	7/782	30/9376	2.79761295822677	MDH1/PCK2/SDHB/SDHD/SUCLG2/ACO2/FH	2.97464585987592
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/782	17/9376	3.52640288852114	CYP27A1/HSD3B7/HSD17B4/SCP2/ACOX2	3.14487715924944
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	15/782	94/9376	1.91326114164445	S100A9/MMP9/S100A8/CXCL2/CCL7/MAPK13/CEBPB/CXCL3/TRADD/CCL20/NFKBIA/CASP8/MAPK1/IL17RA/IKBKG	2.6842901889981
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/782	204/9376	1.58688129983451	PLAUR/CD63/CTSL/FLNA/SDC2/MMP9/CD44/MRAS/ITGB5/FN1/RHOA/MAPK13/ACTB/RRAS/PLAU/ITGAV/MSN/SDC4/PTPN6/HCLS1/TLR2/NRAS/HBEGF/HIF1A/MAPK1/PRKACB/TIAM1	2.55637565073519
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/782	78/9376	1.99829497016198	ITGB2/ITGAM/LY96/RHOA/MAPK13/CFL1/CASP1/PYCARD/C2/CALM3/IL10/MAPK1/IRAK1	2.67056254355016
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/782	31/9376	2.70736737892913	ALDH2/ALDH3B1/DPYD/ALDH3A2/CNDP2/ALDH9A1/ACADS	2.87216584655741
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	29/782	227/9376	1.5317327084061	MGST1/NCF2/GSTO1/CYBA/MGST3/HMOX1/NDUFB9/MAPK13/CBR1/AKR1A1/CYP1B1/SDHB/SOD2/MGST2/UQCRQ/COX7A2/CAT/NDUFB3/SDHD/NFKBIA/NRAS/PPIF/HIF1A/NDUFB2/MAPK1/COX8A/NFE2L2/IKBKG/UQCRC1	2.44630628271878
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	19/782	133/9376	1.71282426013884	HLA-B/ITGB2/TYROBP/HLA-A/FCGR3A/HLA-C/FCER1G/HLA-E/CD48/HCST/ICAM1/IFNAR1/SH3BP2/PTPN6/IFNGR2/IFNGR1/NRAS/MAPK1/LAT	2.4974290321603
NA	NA	hsa04517	IgSF CAM signaling	36/782	299/9376	1.44358432627086	ITGB2/ITGAX/CD84/MYL6/ARPC2/CD48/ARPC1B/ITGAM/RHOA/ARPC4/ARPC5/ICAM1/MAPK13/CD86/TUBB6/ACTB/ACTR3/NRP2/EPB41L3/ACTN1/MBP/MYL12A/SLAMF7/MSN/PTPN6/NRP1/RAP1A/TUBB2A/GLDN/NCK1/SPTAN1/CADM1/MAPK1/ARF6/PPFIA1/CRTAM	2.35142948051325
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/782	48/9376	2.24808184143223	IL4I1/ACAA2/ALDH2/ACAT1/BCAT1/ALDH3A2/HADHB/ALDH9A1/ACADS	2.61493413691387
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/782	90/9376	1.86507530548451	STAT1/MAPK13/CD4/PTPN6/IFNGR2/IFNGR1/NFKBIA/NFKBIE/TLR2/NRAS/HIF1A/MAPK1/LAT/IKBKG	2.487437457258
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/782	136/9376	1.67504137204754	STAT1/IL2RG/IFNAR1/TRADD/RAB9A/STAT2/MSN/HSPA1A/IFIH1/OAS1/OAS2/NFKBIA/BAK1/TLR2/CYCS/CASP8/MX2/IKBKG/IRAK1	2.39196708611669
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	25/782	193/9376	1.55307899235387	CXCL16/STAT1/CCL18/CXCL2/CCL7/RHOA/FGR/CXCR4/ADCY3/CXCL3/CCL20/STAT2/ARRB2/RAP1A/DOCK2/NFKBIA/NRAS/MAPK1/GNG5/GNB4/GNGT2/PRKACB/IKBKG/CCR1/TIAM1	2.34188122766195
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/782	91/9376	1.84457997245721	CD81/LILRB4/RASGRP3/PIK3AP1/PTPN6/NFKBIA/NFKBIE/LILRB1/NRAS/CD72/DAPP1/MAPK1/IKBKG/LILRB3	2.44209110045712
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/782	100/9376	1.79846547314578	IL18/CCL18/CXCL2/IL10RB/CCL7/CXCR4/TNFRSF14/IL2RG/CXCL3/CCL20/IL10RA/IL10/TNFSF14/CSF1/CCR1	2.4214031965777
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/782	50/9376	2.15815856777494	SAT1/ALDH2/LAP3/OAT/ALDH3A2/CNDP2/AOC1/ALDH9A1/SMS	2.47683263296075
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	21/782	158/9376	1.59357700152158	ATP6V1F/RRAGD/SGK1/ATP6V1B2/ATP6V1A/RHOA/FNIP2/ATP6V1D/ATP6V1C1/SLC3A2/RPS6KA1/RRAGC/ATP6V1H/CLIP1/LAMTOR3/CAB39/LAMTOR2/NRAS/MAPK1/RPS6KA2/MAPKAP1	2.26975299194343
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/782	28/9376	2.56923639020826	PPT1/ACAA2/ACOT2/ACOT7/ELOVL1/HADHB	2.50841491617889
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/782	21/9376	2.8547071002314	ALDH2/DPYD/BCAT1/ALDH3A2/PPCS	2.56657775626425
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/782	78/9376	1.84457997245721	ARPC2/FN1/ARPC1B/RHOA/ARPC4/ARPC5/ACTB/ACTR3/ARHGAP10/CLTB/HCLS1/RHOG	2.25935590871592
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/782	70/9376	1.88410668615272	CD36/ACSL1/PCK2/PRKAG2/TRADD/CPT1A/NFKBIA/NFKBIE/RXRA/IKBKG/ACSL4	2.2395641709888
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/782	15/9376	3.19727195225916	HEXB/HEXA/GLB1/ST3GAL5	2.56897370503949
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/782	38/9376	2.2086418091264	IL2RG/CD4/TAP1/CD40/IL7R/PTPRC/IKBKG	2.25192445277869
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	21/782	168/9376	1.49872122762148	FTH1/FTL/GLUL/STAT1/SQSTM1/CAPN2/IFNAR1/TRADD/STAT2/CASP1/CAPN1/PYCARD/CHMP1B/BIRC3/IFNGR2/SMPD1/IFNGR1/CHMP4B/CASP8/CHMP3/CHMP4A	1.9675291689826
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	6/782	31/9376	2.32060061051068	ALDH2/GUSB/AKR1A1/HSD17B14/ALDH3A2/ALDH9A1	2.22153943976055
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/782	65/9376	1.84457997245721	LPL/MGLL/GLA/ALDH2/AKR1A1/AGPAT2/AGPAT3/ALDH3A2/ALDH9A1/DGAT1	2.06105999534121
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/782	17/9376	2.82112231081691	LAMP2/LAMP1/TFRC/NRP2	2.26694086897603
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/782	133/9376	1.53252696959791	SGK1/MAPK13/PCK2/GABARAPL1/PRKAG2/HOMER3/SOD2/GABARAP/IL7R/CAT/PLK3/IL10/NRAS/GADD45B/SGK3/GADD45G/MAPK1	1.86574502111239
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/782	33/9376	2.17995814926761	STX4/STX11/VAMP3/VAMP8/STX7/STX6	2.04819706560394
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	18/782	144/9376	1.49872122762148	C5AR1/CXCL2/LY96/ALDH2/MAPK13/CXCL3/PRKAG2/TRADD/C2/CPT1A/NFKBIA/ACADVL/ALDH3A2/CASP8/ALDH9A1/IL17RA/IKBKG/IRAK1	1.81920877493745
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/782	59/9376	1.82894793879232	TYMP/UPP1/DPYD/DCTD/TK2/TK1/NME3/UCK2/RRM2B	1.9266665354758
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/782	125/9376	1.5346905370844	CTSD/ASAH1/FCER1G/SPHK1/RHOA/MAPK13/SGPL1/TRADD/DEGS1/GNA12/SGMS2/ORMDL2/SMPD1/GNA13/NRAS/MAPK1	1.81532548277041
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/782	116/9376	1.55040126995326	ITGB2/NCF2/CYBA/MMP9/ITGAM/RHOA/CD99/CXCR4/ICAM1/MAPK13/ACTB/ACTN1/MYL12A/MSN/RAP1A	1.79926142313983
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/782	156/9376	1.46029247819529	CD81/NR1H3/STAT1/IFNAR1/TRADD/YWHAH/STAT2/OAS1/PIAS1/OAS2/NFKBIA/BAK1/NRAS/CYCS/RXRA/CASP8/MX2/MAPK1/IKBKG	1.74872716583161
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/782	27/9376	2.22032774462442	HSD17B4/SCP2/ACOT2/ACOT7/ELOVL1	1.91543371493278
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/782	44/9376	1.90746338060916	HEXB/MGAT1/HEXA/MAN1A1/RPN1/MGAT4A/MAGT1	1.81994985463329
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/782	53/9376	1.80977657675047	AP2S1/SLC8A1/ATP1B3/ATP1A1/CLTB/ATP1B1/VDR/PRKACB	1.7832681097801
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/782	120/9376	1.49872122762148	RHOA/MAPK13/RPS6KA1/MATK/SORT1/RAP1A/RIPK2/NFKBIA/CALM3/NFKBIE/NRAS/MAPK1/RPS6KA2/SH2B3/IRAK1	1.65854837857371
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/782	73/9376	1.64243422205094	ELL2/SAMHD1/CXCR4/BST2/CD4/MDFIC/PDCD6IP/CHMP4B/MX2/CHMP4A	1.66214890225252
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/782	122/9376	1.47415202716867	STAT1/SLC16A10/ATP1B3/ACTB/NOTCH2/ATP1A1/ITGAV/ATP1B1/ATP2A2/NRAS/RXRA/HIF1A/MAPK1/THRA/PRKACB	1.59009883530637
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	11/782	83/9376	1.58900563892398	PRDX1/ACSL1/DHRS4/HSD17B4/SOD2/CAT/SCP2/ACOX2/GSTK1/PXMP4/ACSL4	1.62581778580031
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/782	37/9376	1.94428699799544	BAK1/NRAS/GADD45B/RXRA/GADD45G/MAPK1	1.73598522377162
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/782	46/9376	1.82453019014789	FTH1/FTL/HMOX1/ALAS1/GUSB/BLVRA/BLVRB	1.69097036309942
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/782	103/9376	1.51327191915179	ITGB2/PRDX1/FN1/CXCL2/ITGAM/HSPB1/CXCL3/ACTN1/IL10/TLR2/RAB7A/GNA15/PRKACB	1.57996449429854
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/782	205/9376	1.34519368723099	HLA-B/HLA-A/GSN/ATP6V0D1/HLA-C/HLA-F/HLA-E/RHOA/REL/ACTN1/TRADD/YWHAH/CREB3/UBR4/PKM/NFKBIA/BAK1/SP100/NRAS/CASP8/MAPK1/PRKACB/IKBKG	1.50738006954076
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/782	154/9376	1.40140166738632	PDXK/DHRS3/ALDH2/ALAS1/GUSB/AKR1A1/KYNU/BCAT1/SPR/COQ2/PMM1/ALDH3A2/VKORC1/NME3/PPCS/NADK/PNPO/MTHFD2	1.51501981736766
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/782	56/9376	1.71282426013884	MGAT1/SRD5A3/MAN1A1/RPN1/MGAT4A/MAGT1/ALG5/DHRSX	1.61383774755011
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/782	21/9376	2.28376568018512	CHST11/DSE/CSGALNACT2/CHST13	1.77649853101198
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/782	75/9376	1.59863597612958	MGST1/GSTO1/MGST3/SLC31A1/MGST2/BIRC3/BAK1/CYCS/CASP8/MAPK1	1.57007342416738
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/782	85/9376	1.5516172709493	TYMP/UPP1/GUK1/IMPDH1/DCTD/TK2/TK1/NME3/UCK2/RRM2B/ITPA	1.54101699454738
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/782	115/9376	1.45962415211831	SGK1/MAFB/RHOA/ADCY3/MMP14/GNA12/CREB3/ARRB2/GNA13/HBEGF/RXRA/MAPK1/VDR/PRKACB	1.49593994799748
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/782	157/9376	1.37462329157639	HLA-B/HLA-A/HLA-C/HLA-F/MRAS/HLA-E/SQSTM1/MAPK13/CAPN2/RRAS/CAPN1/ZFP36L2/CALM3/HUS1/NRAS/GADD45B/GADD45G/MAPK1	1.42788763962689
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/782	31/9376	1.93383384209224	GLUL/MDH1/ACAT1/CAT/ACO2	1.57091303296368
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	22/782	201/9376	1.31231311473324	BCL2A1/MMP9/ID2/ITGAM/MITF/CEBPA/NUPR1/SPI1/SPINT1/CD86/CEBPB/REL/CD40/PLAU/BIRC3/PBX3/PTCRA/BAK1/GADD45B/RXRA/ITGB7/GADD45G	1.35013300462303
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/782	23/9376	2.08517736016902	ANPEP/ATP6AP2/CTSA/PRCP	1.57173931090677
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	10/782	79/9376	1.5176923824015	MGST1/GSTO1/MGST3/ALDH3B1/CBR1/CYP1B1/HSD11B1/MGST2/CBR3/GSTK1	1.39381535559988
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/782	32/9376	1.87340153452685	GALM/GLA/HK3/GLB1/GAA	1.49284206815188
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/782	122/9376	1.37587522535743	RHOA/MAPK13/CD4/PTPRC/PTPN6/NFKBIA/NFKBIE/IL10/NRAS/NCK1/MAP3K8/MAPK1/LAT/IKBKG	1.26052135984805
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/782	62/9376	1.54706707367379	ADCY3/PRKAG2/SOD2/CAT/HSPA1A/NRAS/CLPB/PRKACB	1.30364590472657
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/782	16/9376	2.24808184143223	HEXB/GLA/HEXA	1.50714997827341
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/782	43/9376	1.67299113781003	CD36/ABCA1/AGPAT2/ACAT1/SLC27A1/DGAT1	1.33421027295772
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/782	103/9376	1.39686638690934	SLC7A7/SLC8A1/KCNN4/SLC16A10/ATP1B3/SLC3A2/PRCP/ATP1A1/ATP1B1/SLC36A1/COL22A1/COL8A2	1.22164251910278
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/782	103/9376	1.39686638690934	MAPK13/CALR/IFNGR2/IFNGR1/NFKBIA/IL10/TLR2/CASP8/MAPK1/GNA15/IKBKG/IRAK1	1.22164251910278
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/782	93/9376	1.41814481753431	FN1/ITGAV/BIRC3/ITGA6/NFKBIA/BAK1/CYCS/GADD45B/RXRA/GADD45G/IKBKG	1.22240567554777
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/782	54/9376	1.55422942123709	SDS/IL4I1/SDSL/MDH1/BCAT1/APIP/SMS	1.23203557208341
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/782	105/9376	1.37025940811107	MRAS/SQSTM1/MITF/MTX1/GABARAPL1/RRAS/GABARAP/AMFR/TFEB/NRAS/RAB7A/HIF1A	1.15087671040295
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/782	105/9376	1.37025940811107	LMNA/ITGB5/SLC8A1/ACTB/ADCY3/ITGAV/ITGA6/ATP2A2/ITGB7/SNTB2/PRKACB/SNTB1	1.15087671040295
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	38/782	388/9376	1.17425580720858	APOE/LPL/LRP1/RTN4/SLC39A8/NDUFB9/SLC39A11/TUBB6/CAPN2/APH1A/SDHB/PSMD9/APH1B/UQCRQ/COX7A2/CAPN1/SLC39A1/NDUFB3/SDHD/TUBB2A/SLC11A2/CALM3/ATP2A2/NRAS/ADAM17/PPIF/CYCS/SLC39A13/CASP8/ADAM10/NDUFB2/MAPK1/COX8A/CSF1/CDK5/IKBKG/PSENEN/UQCRC1	1.05745752290435
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	30/782	300/9376	1.19897698209719	FLNA/MRAS/MAP3K2/VEGFB/HSPB1/DUSP2/DUSP1/MAPK13/RASGRP3/RRAS/TRADD/RPS6KA1/GNA12/DUSP10/HSPA1A/ARRB2/RAP1A/LAMTOR3/RELB/NRAS/MAP3K8/GADD45B/EREG/GADD45G/MAPK1/RPS6KA2/CSF1/PRKACB/IKBKG/IRAK1	1.05659259680338
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/782	75/9376	1.43877237851662	SDS/SDSL/GLUL/PGK1/BCAT1/PRPS2/PGAM1/PKM/ACO2	1.15079092843986
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/782	75/9376	1.43877237851662	CD82/STEAP3/TP53I3/AIFM2/CYCS/GADD45B/CASP8/GADD45G/RRM2B	1.15079092843986
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/782	75/9376	1.43877237851662	GPX1/ASGR1/ATP1B3/ADCY3/ATP1A1/CREB3/ATP1B1/PDIA4/PRKACB	1.15079092843986
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	18/782	170/9376	1.26950503986761	RAB13/MYL6/ARPC2/ARPC1B/RHOA/ARPC4/ARPC5/ACTB/ACTR3/ACTN1/PRKAG2/MYL12A/MSN/RAP1A/ARHGEF2/HCLS1/PRKACB/TIAM1	1.069663573624
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/782	86/9376	1.39415928150836	LMNA/ITGB5/SLC8A1/ACTB/ITGAV/ITGA6/ATP2A2/ITGB7/SNTB2/SNTB1	1.10765488276463
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/782	46/9376	1.56388302012677	PSMB9/PSMB8/PSME2/POMP/PSMD9/PSMB10	1.1564276077245
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/782	87/9376	1.37813446218067	SLC8A1/ATP1B3/UQCRQ/COX7A2/ATP1A1/ATP1B1/ATP2A2/COX8A/ASPH/UQCRC1	1.06884011366809
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	15/782	140/9376	1.28461819510413	SPP1/MRAS/SPHK1/SLC8A1/ADCY3/PRKAG2/RRAS/GNA13/CALM3/NRAS/MAPK1/GNG5/GNB4/GNGT2/PRKACB	1.02347221266214
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	14/782	130/9376	1.29120598072005	MMP9/VEGFB/MAPK13/ADCY3/CREB3/ARRB2/NFKBIA/NRAS/MAPK1/GNG5/GNB4/GNA15/GNGT2/PRKACB	1.00852428838375
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/782	88/9376	1.36247384329226	PLAUR/ITGB2/ITGAX/C5AR1/SERPINA1/ITGAM/CD59/PLAU/C2/CFD	1.03050059150758
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/782	10/9376	2.39795396419437	PAPSS2/PAPSS1	1.33415759628236
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/782	99/9376	1.33219664677465	LMNA/ITGB5/SLC8A1/ACTB/PRKAG2/ITGAV/ITGA6/ATP2A2/ITGB7/SNTB2/SNTB1	1.00230616904213
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/782	28/9376	1.71282426013884	PCBD1/CBR1/SPR/QDPR	1.13944528555647
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/782	89/9376	1.34716514842381	SPP1/CD36/CD44/ITGB5/FN1/ITGAV/SDC4/ITGA6/ITGB7/CD47	0.992623930021677
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/782	38/9376	1.57760129223314	SGK1/ATP1B3/ATP1A1/ATP1B1/MAPK1	1.07617861976538
NA	NA	hsa04518	Integrin signaling	16/782	154/9376	1.24569037101006	SPP1/ITGB2/ITGAX/FLNA/LIMS1/ITGB5/FN1/ITGAM/VEGFB/ICAM1/FERMT3/ACTB/ACTN1/ITGAV/ITGA6/ITGB7	0.927314984614696
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	29/782	298/9376	1.16678968056438	CXCL16/IL1RN/IL18/TNFSF13B/CCL18/CXCL2/IL10RB/CCL7/CXCR4/TNFRSF14/IL2RG/OSM/CD4/IFNAR1/CXCL3/TNFSF12/CD40/CCL20/IL7R/TNFRSF12A/IL10RA/IL13RA1/IFNGR2/IFNGR1/IL10/TNFSF14/IL17RA/CSF1/CCR1	0.882619584514903
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/782	90/9376	1.33219664677465	NCEH1/AQP9/ABCC3/ATP1B3/ADCY3/ATP1A1/ATP1B1/RXRA/CA2/PRKACB	0.955198208900402
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/782	70/9376	1.37025940811107	MGST1/GSTO1/MGST3/CBR1/CYP1B1/HSD11B1/MGST2/GSTK1	0.937918146491468
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/782	212/9376	1.1876658784925	ITGB2/MRAS/ITGAM/VEGFB/RHOA/APBB1IP/MAPK13/ACTB/ADCY3/RASGRP3/RRAS/RALA/RAP1A/DOCK4/CALM3/NRAS/PFN1/MAPK1/LAT/CSF1/TIAM1	0.833685112966806
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	16/782	157/9376	1.22188737029013	NR1H3/CEBPA/NDUFB9/MAPK13/PRKAG2/SDHB/UQCRQ/COX7A2/NDUFB3/SDHD/CYCS/RXRA/CASP8/NDUFB2/COX8A/UQCRC1	0.845730205651081
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	23/782	235/9376	1.17346683354193	MGLL/ACSL1/NDUFB9/MAPK13/ACTB/ADCY3/PRKAG2/SDHB/RPS6KA1/UQCRQ/COX7A2/CREB3/NDUFB3/CPT1A/SDHD/NRAS/CPT2/NDUFB2/COX8A/RPS6KA2/PRKACB/ACSL4/UQCRC1	0.812353147834377
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	11/782	104/9376	1.26814873106433	PLD3/AGPAT2/PLA2G15/PCYT1A/SGMS2/GPD2/AGPAT3/GPCPD1/CDS2/LPCAT2/LPGAT1	0.829463050070816
Organismal Systems	Immune system	hsa04611	Platelet activation	13/782	126/9376	1.23703974343361	FCER1G/RHOA/APBB1IP/FERMT3/MAPK13/ACTB/ADCY3/MYL12A/VAMP8/RAP1A/GNA13/MAPK1/PRKACB	0.808028938322855
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/782	83/9376	1.30009552275599	IL18/DNASE2/SAMHD1/CASP1/PYCARD/NFKBIA/CASP8/IKBKG/POLR3GL	0.82834629431908
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/782	41/9376	1.46216705133803	TYMP/MMP9/NRAS/HBEGF/MAPK1	0.894592160295912
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/782	12/9376	1.99829497016198	COQ2/VKORC1	1.04378281797234
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/782	12/9376	1.99829497016198	ASGR1/NPC1	1.04378281797234
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/782	32/9376	1.49872122762148	BIRC3/BAK1/CYCS/CASP8	0.852428120906637
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	16/782	163/9376	1.17690992107699	MMP9/ATP6AP1/STAT1/MAPK13/IFNAR1/STAT2/CREB3/IFIH1/NFKBIA/TLR2/NRAS/CYCS/CASP8/MAPK1/IKBKG/IRAK1	0.687284889055485
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/782	76/9376	1.26208103378651	ATP1B3/ACTB/ADCY3/ATP1A1/ATP1B1/CALM3/CA2/PRKACB	0.691977948859182
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/782	109/9376	1.20997677092377	CD36/NR1H3/PCK2/PRKAG2/RPS6KA1/CREB3/SLC27A1/CPT1A/NFKBIA/RPS6KA2/SLC27A3	0.665129576660836
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/782	87/9376	1.24032101596261	RHOA/RALA/BAK1/NRAS/CYCS/GADD45B/EREG/GADD45G/MAPK1	0.679294715792322
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/782	233/9376	1.1320812706497	VIM/SDC2/LMNA/FMNL2/ITGB5/FN1/ZYX/ATP1B3/ACTB/PLEC/PDLIM7/ATP1A1/ITGAV/INF2/SDC4/ATP1B1/ITGA6/SPTAN1/FMNL1/ITGB7/SNTB2/SNTB1	0.61583756839685
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/782	143/9376	1.17382361883641	FCGR3A/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA2/CD86/ACTN1/CD40/C2/IL10	0.631824886864995
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	25/782	268/9376	1.11844867732947	SLC39A8/NDUFB9/SLC39A11/DUSP1/TUBB6/SDHB/PSMD9/UQCRQ/COX7A2/UBE2L6/SLC39A1/NDUFB3/UBE2J1/SDHD/TUBB2A/SLC11A2/CALM3/PPIF/CYCS/SLC39A13/NDUFB2/COX8A/NFE2L2/PRKACB/UQCRC1	0.593440854851534
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/782	67/9376	1.252662518609	RPS6KA1/RAP1A/CALM3/NRAS/MAPK1/RPS6KA2/PRKACB	0.626063013380522
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/782	35/9376	1.37025940811107	FBP1/HK3/HSD17B14/PMM1	0.661964620606347
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/782	68/9376	1.2342410109824	BCL2A1/ITGAM/CEBPA/SPI1/NRAS/MAPK1/IKBKG	0.584763885177405
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/782	205/9376	1.1112469590169	CTSD/CD36/NCF2/CYBA/MMP9/NDUFB9/MAPK13/SDHB/UQCRQ/COX7A2/NDUFB3/SDHD/MPC1/ATP2A2/PPIF/CPT2/NDUFB2/COX8A/UQCRC1	0.485789442339621
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/782	69/9376	1.2163534600986	FCER1G/ALOX5AP/ALOX5/MAPK13/NRAS/MAPK1/LAT	0.544095173768268
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/782	149/9376	1.12655555364836	MRAS/FCER1G/SPHK1/RHOA/AGPAT2/ADCY3/RRAS/GNA12/RALA/AGPAT3/GNA13/NRAS/MAPK1/ARF6	0.469716073745311
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/782	195/9376	1.10674798347433	ITGB2/NCF2/FCGR3A/C5AR1/CYBA/AQP9/ITGAM/FPR3/MAPK13/SIGLEC9/ACTB/ATG7/CASP4/CLEC7A/CASP1/TLR2/PPIF/MAPK1	0.454384315331326
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/782	93/9376	1.16030030525534	MAP3K2/MAPK13/ADCY3/MMP14/CALM3/NRAS/HBEGF/MAPK1/PRKACB	0.468622340201773
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/782	93/9376	1.16030030525534	LYZ/KCNN4/ATP1B3/ADCY3/BST1/ATP1A1/ATP1B1/CALM3/PRKACB	0.468622340201773
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/782	48/9376	1.24893435635124	HK3/ATP1B3/ATP1A1/ATP1B1/SLC2A5	0.521557901624897
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/782	71/9376	1.18208998234934	SLC16A3/HK3/PGAM1/PKM/NRAS/HIF1A/MAPK1	0.464567024132107
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/782	49/9376	1.22344590009917	GALNT6/COLGALT1/PLOD3/LFNG/GALNT7	0.473032284182079
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/782	16/9376	1.49872122762148	IL4I1/ALDH3B1	0.602242306892038
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/782	107/9376	1.12053923560485	FBP1/PCK2/PRKAG2/CREB3/PGAM1/SIK1/PKM/CPT1A/CALM3/PRKACB	0.378264183037367
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/782	17/9376	1.41056115540845	PAPSS2/PAPSS1	0.51106828842921
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/782	17/9376	1.41056115540845	GLUL/CA2	0.51106828842921
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	21/782	238/9376	1.05792086655634	MRAS/VEGFB/RHOA/REL/RASGRP3/RRAS/RALA/RAP1A/CALM3/NRAS/MAPK1/GNG5/GNB4/GNGT2/LAT/CSF1/PRKACB/IKBKG/ARF6/RASAL2/TIAM1	0.273016749976194
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/782	238/9376	1.05792086655634	C5AR1/STAT1/MAPK13/IFNAR1/STAT2/CASP1/NRP1/IFIH1/C2/OAS1/OAS2/NFKBIA/RPS27L/TLR2/HBEGF/ADAM17/MX2/MAPK1/IKBKG/CFD/IRAK1	0.273016749976194
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	18/782	203/9376	1.06313229939652	SPP1/FLNA/EMP1/ITGB5/FN1/ZYX/VEGFB/RHOA/ACTB/CAPN2/ACTN1/MYL12A/ITGAV/BIRC3/RAP1A/ITGA6/ITGB7/MAPK1	0.27430597631099
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/782	63/9376	1.14188284009256	ALDH2/COLGALT1/PLOD3/ACAT1/ALDH3A2/ALDH9A1	0.340836962710862
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/782	52/9376	1.15286248278576	ALOX5/ADCY3/CYP1B1/ACOT2/PRKACB	0.333420876269048
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/782	18/9376	1.33219664677465	ACSL1/ACSL4	0.42553111024163
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/782	18/9376	1.33219664677465	PRDX1/LMBRD1	0.42553111024163
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/782	41/9376	1.16973364107043	SDS/SDSL/ALAS1/PGAM1	0.328544374161854
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/782	76/9376	1.1043209045632	CAMK1/BAK1/CALM3/NRAS/GADD45B/GADD45G/MAPK1	0.275440631929053
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/782	77/9376	1.08997907463381	STAT1/RALA/BAK1/GADD45B/GADD45G/MAPK1/IKBKG	0.239144337070168
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/782	77/9376	1.08997907463381	NFKBIA/BAK1/NRAS/GADD45B/GADD45G/MAPK1/IKBKG	0.239144337070168
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/782	89/9376	1.07773211873904	GLUL/ADCY3/GABARAPL1/GABARAP/GNG5/GNB4/GNGT2/PRKACB	0.222253764647681
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/782	102/9376	1.05792086655634	RHOA/ATP1B3/ADCY3/BST1/ATP1A1/ATP1B1/RAP1A/ATP2A2/CA2	0.177416060224498
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/782	31/9376	1.16030030525534	FBP1/PRPS2/DERA	0.269660219369947
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/782	31/9376	1.16030030525534	TMEM208/SEC11C/SEC61A1	0.269660219369947
NA	NA	hsa04981	Folate transport and metabolism	3/782	31/9376	1.16030030525534	ABCC3/SLCO2B1/MTHFS	0.269660219369947
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/782	68/9376	1.05792086655634	DHRS3/ALDH1A1/DHRS4/DHRS4L2/DHRS9/DGAT1	0.144594794986064
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/782	44/9376	1.08997907463381	STX4/ADCY3/CREB3/PRKACB	0.180456211566253
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/782	20/9376	1.19897698209719	LIPA/SOAT1	0.26869777544436
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/782	20/9376	1.19897698209719	NPL/CYB5R3	0.26869777544436
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/782	32/9376	1.12404092071611	ATG7/GABARAPL1/GABARAP	0.212014173661394
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	14/782	166/9376	1.01118540658799	SLC8A1/RHOA/RGS2/ATP1B3/ADCY3/ATP1A1/GNA12/CREB3/ATP1B1/GNA13/CALM3/ATP2A2/PPIF/MAPK1	0.043859870418162
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/782	45/9376	1.06575731741972	ABCC3/ABCA1/TAP1/ABCB8	0.13337596971858
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/782	168/9376	0.999147485080989	STAT1/IL10RB/IL2RG/OSM/IFNAR1/IL7R/STAT2/IL10RA/IL13RA1/PTPN6/IFNGR2/PIAS1/IFNGR1/IL10	-0.0033632977247566
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/782	34/9376	1.05792086655634	BHLHE40/PRKAG2/BHLHE41	0.102057733159702
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/782	59/9376	1.01608218821795	MGLL/ADCY3/FABP4/ABHD5/PRKACB	0.0373787211557558
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/782	59/9376	1.01608218821795	BAK1/NRAS/GADD45B/GADD45G/MAPK1	0.0373787211557558
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/782	72/9376	0.999147485080989	MAPK13/TRADD/IFIH1/NFKBIA/CASP8/IKBKG	-0.00219040652895683
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/782	60/9376	0.999147485080989	SPHK1/HSPB1/MAPK13/NRAS/MAPK1	-0.00199827020628241
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/782	184/9376	0.977426887579228	PLXNC1/RHOA/CXCR4/SEMA3C/CFL1/LIMK1/RRAS/MYL12A/PLXNB2/NRP1/SEMA4A/NRAS/NCK1/MAPK1/CDK5	-0.0932796028213138
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/782	73/9376	0.985460533230564	MGST1/GSTO1/MGST3/ALDH3B1/MGST2/GSTK1	-0.0376174834724763
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/782	73/9376	0.985460533230564	MITF/BAK1/NRAS/GADD45B/GADD45G/MAPK1	-0.0376174834724763
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/782	73/9376	0.985460533230564	BAK1/NRAS/GADD45B/RXRA/GADD45G/MAPK1	-0.0376174834724763
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/782	98/9376	0.978756720079336	CAMK1/ATP1B3/ADCY3/ATP1A1/CREB3/ATP1B1/CALM3/PRKACB	-0.0637674081978949
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/782	23/9376	1.04258868008451	ACAT1/ICMT	0.0616842049469509
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/782	86/9376	0.97591149705585	KCNN4/ATP1B3/ADCY3/ATP1A1/CREB3/ATP1B1/PRKACB	-0.0676928063255886
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/782	36/9376	0.999147485080989	GUSB/AKR1A1/CRYL1	-0.00154586349006012
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/782	36/9376	0.999147485080989	HK3/GYG1/GAA	-0.00154586349006012
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/782	99/9376	0.968870288563383	MMP9/MAPK13/ADCY3/NOTCH2/NRAS/HBEGF/MAPK1/PRKACB	-0.0939247945948957
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/782	37/9376	0.972143498997719	IL4I1/GLUL/ASRGL1	-0.0512116276392623
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/782	37/9376	0.972143498997719	HK3/PMM1/NAGK	-0.0512116276392623
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/782	37/9376	0.972143498997719	IL18/ICAM1/IL10	-0.0512116276392623
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/782	63/9376	0.951569033410466	LTA4H/ALOX5/CBR1/CBR3/GPX4	-0.116342917457527
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	22/782	275/9376	0.959181585677749	NCF2/CYBA/NDUFB9/MAPK13/TUBB6/PRNP/SDHB/PSMD9/UQCRQ/COX7A2/CREB3/HSPA1A/NDUFB3/SDHD/TUBB2A/PPIF/CYCS/NDUFB2/MAPK1/COX8A/PRKACB/UQCRC1	-0.207237936550802
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/782	139/9376	0.948830705256766	CTSD/MMP9/ADCY3/CREB3/FKBP5/HSPA1A/CALM3/NRAS/HBEGF/MAPK1/PRKACB	-0.183333867262225
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/782	89/9376	0.943015603896664	MAP3K2/TUBB6/ADCY3/TUBB2A/NRAS/MAPK1/PRKACB	-0.162931318039317
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/782	38/9376	0.946560775339884	BST1/NNT/NADK	-0.0995672132479274
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/782	51/9376	0.940374103605637	PLA2G7/PLD3/TMEM86A/LPCAT2	-0.128791419233604
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/782	90/9376	0.932537652742256	ADCY3/PRKAG2/SOD2/CAT/CREB3/NRAS/PRKACB	-0.193981227367798
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/782	116/9376	0.930240761971955	SLC1A3/GLUL/ADCY3/HOMER3/MAPK1/GNG5/GNB4/GNGT2/PRKACB	-0.228042907499376
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/782	65/9376	0.922289986228605	SPP1/KCNN4/ARRB2/NRAS/MAPK1	-0.189638643876026
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	17/782	217/9376	0.939290723301943	MGST1/GSTO1/MGST3/ADCY3/CYP1B1/NOTCH2/RPS6KA1/MGST2/CREB3/ARRB2/NRAS/RXRA/MAPK1/MIR29A/RPS6KA2/VDR/PRKACB	-0.272930603876117
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/782	66/9376	0.908315895528172	SRD5A3/CYP1B1/HSD11B1/HSD17B11/DHRS9	-0.225466755174641
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/782	93/9376	0.902455792976377	RHOA/ACTB/ACTN1/MYL12A/PTPN6/RAP1A/MAPK1	-0.285160995144225
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/782	106/9376	0.904888288375235	MMP9/SPINT1/PLAU/CREB3/NFKBIA/NRAS/MAPK1/IKBKG	-0.297056050701648
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/782	27/9376	0.888131097849768	ACAT1/ACADS	-0.175590096820276
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/782	70/9376	0.856412130069419	RAP1A/NRAS/HIF1A/MAPK1/FH	-0.363727878005868
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/782	149/9376	0.885150792152286	MGLL/NDUFB9/MAPK13/ADCY3/NDUFB3/NDUFB2/MAPK1/GNG5/GNB4/GNGT2/PRKACB	-0.426267496192848
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/782	110/9376	0.871983259707045	HMOX1/HK3/TFRC/PGK1/IFNGR2/IFNGR1/HIF1A/MAPK1	-0.407388062762777
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/782	110/9376	0.871983259707045	HAMP/ID2/EMP3/RHOA/TFRC/SKIL/SMAD7/MAPK1	-0.407388062762777
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/782	97/9376	0.865241121101063	ADCY3/CALM3/MAPK1/GNG5/GNB4/GNGT2/PRKACB	-0.402424125639664
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/782	44/9376	0.817484305975355	POLD4/MBD4/POLE4	-0.366041669456094
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/782	30/9376	0.799317988064791	PIGP/PIGT	-0.332083674198422
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/782	30/9376	0.799317988064791	ABCC3/IKBKG	-0.332083674198422
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	11/782	154/9376	0.856412130069419	SLC8A1/MAPK13/ATP1B3/ADCY3/ATP1A1/CREB3/ATP1B1/CALM3/ATP2A2/MAPK1/PRKACB	-0.54194709726772
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/782	154/9376	0.856412130069419	MYL6/RHOA/CAMK1/RGS2/ACTB/ADCY3/PRKAG2/CALM3/NRAS/MAPK1/PRKACB	-0.54194709726772
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/782	101/9376	0.830974146007951	MITF/ADCY3/CREB3/CALM3/NRAS/MAPK1/PRKACB	-0.51516720281491
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/782	101/9376	0.830974146007951	STAT1/FN1/VEGFB/ICAM1/MAPK13/NRAS/MAPK1	-0.51516720281491
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/782	60/9376	0.799317988064791	GNA12/GNA13/NRAS/MAPK1	-0.470392806558892
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/782	128/9376	0.843030690537084	GUK1/PAPSS2/ADCY3/PAPSS1/IMPDH1/PRPS2/NME3/RRM2B/ITPA	-0.539370465656317
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/782	115/9376	0.834070944067608	ADCY3/CREB3/NRAS/MAPK1/GNG5/GNB4/GNGT2/PRKACB	-0.54004973881111
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/782	115/9376	0.834070944067608	ALOX5/DUSP1/NRAS/MAPK1/GNG5/GNB4/GNGT2/PRKACB	-0.54004973881111
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	27/782	362/9376	0.894264599906742	SPP1/SGK1/ITGB5/FN1/VEGFB/PCK2/IL2RG/OSM/IFNAR1/YWHAH/IL7R/ITGAV/CREB3/PIK3AP1/ITGA6/TLR2/NRAS/RXRA/ITGB7/EREG/SGK3/MAPK1/GNG5/GNB4/GNGT2/CSF1/IKBKG	-0.618881159038627
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/782	32/9376	0.749360613810742	SUCLG2/ACADS	-0.428399773583848
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/782	47/9376	0.765304456657779	HK3/PKM/MAPK1	-0.486550099044852
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/782	170/9376	0.846336693245073	MGST1/GSTO1/MGST3/HMOX1/ACTB/MGST2/BAK1/NRAS/GADD45B/GADD45G/MAPK1/NFE2L2	-0.609888564306997
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/782	33/9376	0.726652716422537	BCAT1/ACO2	-0.47448217079705
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	36/782	480/9376	0.89923273657289	GPX1/SQSTM1/NDUFB9/MAPK13/TUBB6/CAPN2/PRNP/RAB1A/SDHB/PSMD9/UQCRQ/COX7A2/CAT/UBE2L6/CAPN1/DERL1/NDUFB3/UBE2J1/ATXN1/SDHD/TUBB2A/BAK1/CALM3/ATP2A2/NRAS/PPIF/CYCS/CASP8/NDUFB2/MAPK1/COX8A/CSF1/CDK5/C9orf72/FIG4/UQCRC1	-0.683650343039143
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/782	91/9376	0.790534273910233	ADCY3/ARRB2/GNG5/GNB4/GNGT2/PRKACB	-0.605667198153371
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	27/782	368/9376	0.879684198821306	GPX1/SQSTM1/NDUFB9/CHCHD10/MAPK13/ANXA11/TUBB6/ACTB/RAB1A/SDHB/PSMD9/UQCRQ/COX7A2/CAT/CASP1/DERL1/NDUFB3/SDHD/TUBB2A/CYCS/PFN1/NDUFB2/COX8A/C9orf72/NUP214/FIG4/UQCRC1	-0.710270419383679
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/782	49/9376	0.734067540059502	CREB3/CDK5/PRKACB	-0.562975820581101
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/782	65/9376	0.737831988982884	NCEH1/ADCY3/CREB3/PRKACB	-0.639778371719473
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	22/782	308/9376	0.856412130069419	GPX1/SLC1A3/AP2S1/NDUFB9/TUBB6/SDHB/PSMD9/SOD2/UQCRQ/COX7A2/CREB3/CLTB/NDUFB3/SDHD/TGM2/TUBB2A/PPIF/CYCS/CASP8/NDUFB2/COX8A/UQCRC1	-0.77290958934899
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/782	122/9376	0.786214414489959	FBP1/CD36/PCK2/PRKAG2/TBC1D1/CREB3/CPT1A/CAB39	-0.716943492901864
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/782	36/9376	0.666098323387326	GALNT6/GALNT7	-0.605463200273498
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/782	36/9376	0.666098323387326	POLD4/POLE4	-0.605463200273498
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/782	138/9376	0.781941510063383	FBP1/RHOQ/HK3/PCK2/PRKAG2/CALM3/NRAS/MAPK1/PRKACB	-0.778421646826579
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/782	37/9376	0.648095665998479	IL4I1/ALDH3B1	-0.64694391144289
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/782	69/9376	0.69505912005634	CTSB/PTGER4/CALM3/PRKACB	-0.766878703887534
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/782	99/9376	0.726652716422537	PTGER4/TRPV2/MAPK13/ADCY3/CALM3/PRKACB	-0.824745437019579
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/782	39/9376	0.61485999081907	MTHFS/MTHFD2	-0.727007013550758
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/782	71/9376	0.675479989913908	STAT1/MAPK13/NRAS/MAPK1	-0.827949420456213
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/782	86/9376	0.697079640754178	NRAS/NCK1/HBEGF/EREG/MAPK1	-0.851257932385733
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/782	226/9376	0.795781182807867	SUCNR1/RHOA/ATP1B3/ADCY3/RRAS/ATP1A1/CREB3/ATP1B1/RAP1A/NFKBIA/CALM3/ATP2A2/MAPK1/PRKACB/TIAM1	-0.937412562009254
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/782	23/9376	0.521294340042255	GLUL	-0.693343348032959
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/782	23/9376	0.521294340042255	POLD4	-0.693343348032959
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/782	133/9376	0.721189162163721	MAPK13/CREB3/ARRB2/CALM3/GNG5/GNB4/GNGT2/PRKACB	-0.976833028603206
NA	NA	hsa04382	Cornified envelope formation	14/782	217/9376	0.773533536836895	S100A10/S100A6/S100A11/ST14/S100A9/S100A4/S100A8/PLEC/UGCG/SLC27A1/CAPN1/ITGA6/ELOVL1/ABHD5	-1.01812493758097
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/782	24/9376	0.499573742540494	HS3ST1	-0.740431354071642
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/782	134/9376	0.715807153490858	MYL6/RHOA/ADCY3/GNA12/GNA13/CALM3/MAPK1/PRKACB	-0.99947951902386
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/782	122/9376	0.687937612678714	STAT1/MAPK13/ADCY3/CREB3/NRAS/MAPK1/PRKACB	-1.04652096836018
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/782	194/9376	0.741635246658054	MYL6/MYO1E/TUBB6/ACTB/MYL12A/KIFC3/TUBB2A/MYO1C/MYO5A/KIF1C/MYO9B/DYNLT3	-1.09687421367971
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/782	26/9376	0.461144993114303	LMBRD1	-0.829935097700942
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/782	138/9376	0.69505912005634	MAPK13/ADCY3/YWHAH/RPS6KA1/CALM3/MAPK1/RPS6KA2/PRKACB	-1.08857298800651
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/782	110/9376	0.653987444780284	MAPK13/ADCY3/RPS6KA1/MAPK1/RPS6KA2/PRKACB	-1.10111680894218
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/782	63/9376	0.570941420046279	BAK1/GADD45B/GADD45G	-1.03070267779431
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	16/782	254/9376	0.755261091084842	SPHK1/VEGFB/SLC8A1/CXCR4/CAMK1/ADCY3/P2RX7/P2RX4/MCOLN1/CALM3/ATP2A2/TFEB/PPIF/GNA15/ASPH/PRKACB	-1.19279602721492
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/782	28/9376	0.428206065034709	ST3GAL6	-0.914009160377176
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/782	29/9376	0.413440338654202	CALM3	-0.954259319819568
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/782	99/9376	0.605543930352115	PCYT1A/GPCPD1/NRAS/HIF1A/MAPK1	-1.19015575823192
NA	NA	hsa04081	Hormone signaling	13/782	219/9376	0.711721496222074	HAMP/RHOA/SLC16A10/ADCY3/GNA12/ITGAV/GNA13/GNG5/GNB4/GNA15/GNGT2/THRA/PRKACB	-1.30211412397799
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/782	69/9376	0.521294340042255	CREB3/CALM3/PRKACB	-1.20386999643947
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/782	34/9376	0.352640288852114	POLR3GL	-1.14066084619792
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/782	56/9376	0.428206065034709	ARRB2/PRKACB	-1.29454437463656
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/782	142/9376	0.591044991174669	UBE2D1/UBE2L6/BIRC3/UBE2J1/PIAS1/UBE2E2/UBE2A	-1.4812082042002
NA	NA	hsa04519	Cadherin signaling	25/782	404/9376	0.741941201792814	VIM/LHFPL2/ARPC2/MRAS/ARPC1B/RHOA/ARPC4/ARPC5/MAPK13/MYO1E/ACTB/ACTR3/APH1A/ACTN1/RRAS/YWHAH/APH1B/NFKBIA/MYO1C/NRAS/ADAM10/MAPK1/IKBKG/TMC6/PSENEN	-1.59939620266334
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/782	78/9376	0.461144993114303	PI4K2A/ITPK1/FIG4	-1.4415038047922
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/782	98/9376	0.489378360039668	PI4K2A/CALM3/CDS2/ITPK1	-1.53276794692876
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/782	41/9376	0.292433410267606	POLD4	-1.36959898424032
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/782	63/9376	0.380627613364186	POLD4/POLE4	-1.4878825579627
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/782	155/9376	0.541473475785826	NCEH1/ADCY3/CREB3/RAP1A/MAPK1/PRKACB/FH	-1.73633148871824
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/782	44/9376	0.272494768658452	TAF13	-1.45903743150079
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/782	191/9376	0.564962975857313	CREB3/SLC29A3/CALM3/NRAS/MAPK1/GNG5/GNB4/GNGT2/PRKACB	-1.83229190468843
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/782	144/9376	0.499573742540494	ID2/MAPK13/PCGF5/SKIL/NRAS/MAPK1	-1.82542829211673
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/782	148/9376	0.48607174949886	NOTCH2/BAK1/NRAS/GADD45B/GADD45G/MAPK1	-1.90095088548238
NA	NA	hsa04082	Neuroactive ligand signaling	9/782	199/9376	0.542250896425863	SLC1A3/ADCY3/P2RY11/P2RX4/OGFR/GNG5/GNB4/GNGT2/PRKACB	-1.96877014459979
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/782	150/9376	0.479590792838875	BAK1/NRAS/GADD45B/RXRA/GADD45G/MAPK1	-1.93809569114019
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/782	80/9376	0.299744245524297	NRAS/MAPK1	-1.89733912518948
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/782	157/9376	0.458207763858797	ITGB2/ID2/ACTB/YWHAH/BIRC3/SMAD7	-2.06505696422798
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/782	83/9376	0.288910116167997	PCGF5/UBE2D1	-1.96280392586522
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/782	144/9376	0.416311452117079	PSMD9/ATXN1/ATP2A2/PPIF/CYCS	-2.12914804770457
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	15/782	323/9376	0.556800456082285	VIM/ST14/MMP9/CD44/HMOX1/RHOA/CYP1B1/NOTCH2/PLAU/ZEB2/BAK1/MARCKS/NRAS/MAPK1/MIR29A	-2.44509448360637
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/782	117/9376	0.307429995409535	ACTB/TFPT/MBD2	-2.27387144077575
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/782	78/9376	0.153714997704768	BTG1	-2.26391707446067
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/782	108/9376	0.222032774462442	TMEM33/NUP214	-2.45285291464255
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/782	86/9376	0.139415928150836	PRKACB	-2.41838818450602
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/782	178/9376	0.269433029684761	MMP7/RHOA/TLE3/PRKACB	-2.96834702307701
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/782	158/9376	0.227653857360225	YWHAH/GADD45B/GADD45G	-2.95334044880253
Genetic Information Processing	Translation	hsa03010	Ribosome	4/782	222/9376	0.21603188866616	RPS27L/MRPL44/MRPL24/MRPL34	-3.56583112050294
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/782	183/9376	0.131035735748326	NOP10/POP4	-3.58088333146773
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/782	370/9376	0.291643049699316	TSPO/C5AR1/FPR3/PTGER4/P2RX7/P2RY11/P2RX4/OGFR/THRA	-4.19351682948843
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/782	243/9376	0.0493406165472093	HSPA1A	-4.52910810836074
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/782	449/9376	0.160219641260203	SLC8A1/RGS2/ADCY3/ARRB2/CALM3/PRKACB	-5.50082027913702