ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0023026 MHC class II protein complex binding 13/719 27/18639 0.481481481481481 12.4816875289754 4.58195107543022e-12 4.42616473886559e-09 GO:0023023 MHC protein complex binding 13/719 37/18639 0.351351351351351 9.10825846709018 5.69272323435923e-10 2.52336491214472e-07 GO:0042605 peptide antigen binding 14/719 45/18639 0.311111111111111 8.06509040333797 7.83653699423825e-10 2.52336491214472e-07 GO:0042277 peptide binding 28/719 249/18639 0.112449799196787 2.91509291686915 4.1266674366403e-07 9.96590185948633e-05 GO:0140375 immune receptor activity 21/719 156/18639 0.134615384615385 3.48970257836739 6.21452986704686e-07 0.000120064717031345 GO:0005044 scavenger receptor activity 8/719 27/18639 0.296296296296296 7.68103847936949 5.45491866800538e-06 0.000764030624731061 GO:0038024 cargo receptor activity 12/719 65/18639 0.184615384615385 4.78587782176099 6.09971751203676e-06 0.000764030624731061 GO:0030695 GTPase regulator activity 40/719 489/18639 0.081799591002045 2.12053209553146 6.78046240993224e-06 0.000764030624731061 GO:0060589 nucleoside-triphosphatase regulator activity 40/719 490/18639 0.0816326530612245 2.11620447900996 7.11829774594156e-06 0.000764030624731061 GO:0001618 virus receptor activity 13/719 81/18639 0.160493827160494 4.16056250965848 1.25429453448397e-05 0.00121164852031151 GO:0140272 exogenous protein binding 13/719 82/18639 0.158536585365854 4.10982394246752 1.43874869232773e-05 0.00126348294253508 GO:0005543 phospholipid binding 39/719 497/18639 0.0784708249496982 2.03423881256944 2.27897996205179e-05 0.00183457886945169 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 38/719 484/18639 0.0785123966942149 2.03531649789078 2.86256438112943e-05 0.00212710553243925 GO:0042608 T cell receptor binding 5/719 11/18639 0.454545454545455 11.7834113035782 3.20616757750945e-05 0.00221225562848152 GO:0001216 DNA-binding transcription activator activity 38/719 491/18639 0.0773930753564155 2.00629976574162 3.91049519169889e-05 0.00251835890345409 GO:0004875 complement receptor activity 5/719 12/18639 0.416666666666667 10.8014603616134 5.3217471650609e-05 0.00321300485090552 GO:0001540 amyloid-beta binding 12/719 83/18639 0.144578313253012 3.74797660740319 7.78136324642626e-05 0.00442164523296927 GO:0035325 Toll-like receptor binding 5/719 13/18639 0.384615384615385 9.9705787953354 8.37347668284226e-05 0.00449376581979201 GO:0005096 GTPase activator activity 24/719 271/18639 0.0885608856088561 2.29580854918424 0.000141096474572791 0.00703190013894291 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 8/719 41/18639 0.195121951219512 5.05824485226772 0.000145587994595091 0.00703190013894291 GO:0071813 lipoprotein particle binding 7/719 32/18639 0.21875 5.67076668984701 0.000178706518822573 0.00784684078102753 GO:0071814 protein-lipid complex binding 7/719 32/18639 0.21875 5.67076668984701 0.000178706518822573 0.00784684078102753 GO:0015485 cholesterol binding 9/719 54/18639 0.166666666666667 4.32058414464534 0.000201657593593156 0.00846961893091255 GO:0033218 amide binding 22/719 247/18639 0.0890688259109312 2.30897614207767 0.000243124302023893 0.00978575315646168 GO:0032934 sterol binding 10/719 68/18639 0.147058823529412 3.81228012762824 0.000263399863075273 0.0101777707092285 GO:0120020 cholesterol transfer activity 6/719 25/18639 0.24 6.22164116828929 0.000304697549447789 0.0113206858756371 GO:0140297 DNA-binding transcription factor binding 35/719 488/18639 0.0717213114754098 1.85926776716295 0.00033802809596814 0.0120938941001934 GO:0030169 low-density lipoprotein particle binding 5/719 17/18639 0.294117647058824 7.62456025525648 0.000354002479187939 0.0122130855319839 GO:0005131 growth hormone receptor binding 4/719 10/18639 0.4 10.3694019471488 0.00038280943915508 0.0123264639407936 GO:0032395 MHC class II receptor activity 4/719 10/18639 0.4 10.3694019471488 0.00038280943915508 0.0123264639407936 GO:0038187 pattern recognition receptor activity 8/719 48/18639 0.166666666666667 4.32058414464534 0.000453333815688025 0.0139566175524341 GO:0043394 proteoglycan binding 7/719 37/18639 0.189189189189189 4.90444686689471 0.0004623310162297 0.0139566175524341 GO:0031625 ubiquitin protein ligase binding 24/719 302/18639 0.0794701986754967 2.060146082215 0.000692494549001521 0.0202712040707718 GO:0035259 nuclear glucocorticoid receptor binding 4/719 12/18639 0.333333333333333 8.64116828929068 0.000848246362947303 0.0241001760766793 GO:0046332 SMAD binding 10/719 79/18639 0.126582278481013 3.28145631238887 0.00089274691400296 0.0246398148264817 GO:0005496 steroid binding 12/719 108/18639 0.111111111111111 2.88038942976356 0.000933629821143957 0.0250524002006962 GO:0003823 antigen binding 16/719 174/18639 0.0919540229885057 2.38377056256295 0.00117328009656877 0.0302009552247579 GO:0017154 semaphorin receptor activity 4/719 13/18639 0.307692307692308 7.97646303626832 0.00118802929455569 0.0302009552247579 GO:0120015 sterol transfer activity 6/719 32/18639 0.1875 4.86065716272601 0.00123907780376161 0.0306910040624029 GO:0008093 cytoskeletal anchor activity 5/719 22/18639 0.227272727272727 5.8917056517891 0.0012836501024532 0.0310001499742447 GO:0019955 cytokine binding 14/719 144/18639 0.0972222222222222 2.52034075104312 0.00137231688404512 0.0323331246338435 GO:0005085 guanyl-nucleotide exchange factor activity 19/719 230/18639 0.0826086956521739 2.14150692386769 0.00154162591512494 0.0354573960478736 GO:0044389 ubiquitin-like protein ligase binding 24/719 322/18639 0.0745341614906832 1.93218669822649 0.00166704422567241 0.0374503423720824 GO:0015295 solute:proton symporter activity 5/719 24/18639 0.208333333333333 5.40073018080668 0.00194378851813408 0.0426749933753982 GO:0004197 cysteine-type endopeptidase activity 10/719 88/18639 0.113636363636364 2.94585282589455 0.00205246526732043 0.0440595877384785 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 25/719 349/18639 0.0716332378223496 1.85698458938911 0.00231400333122611 0.0477548851341758 GO:0044183 protein folding chaperone 9/719 75/18639 0.12 3.11082058414465 0.00232347784814313 0.0477548851341758 GO:0060590 ATPase regulator activity 7/719 49/18639 0.142857142857143 3.70335783826744 0.00258629562865122 0.0520491995266058 GO:0050750 low-density lipoprotein particle receptor binding 5/719 26/18639 0.192307692307692 4.9852893976677 0.00282267386403398 0.0541438856531391 GO:0070412 R-SMAD binding 5/719 26/18639 0.192307692307692 4.9852893976677 0.00282267386403398 0.0541438856531391 GO:0043178 alcohol binding 10/719 92/18639 0.108695652173913 2.81777226824696 0.00285852812454461 0.0541438856531391 GO:0001671 ATPase activator activity 5/719 27/18639 0.185185185185185 4.80064904960593 0.00335581250332192 0.0623406707347881 GO:0035091 phosphatidylinositol binding 21/719 284/18639 0.073943661971831 1.91687888107505 0.0034618808276549 0.0630976769719743 GO:0005080 protein kinase C binding 7/719 52/18639 0.134615384615385 3.48970257836739 0.0036466997538883 0.0652354067084463 GO:0001530 lipopolysaccharide binding 6/719 41/18639 0.146341463414634 3.79368363920079 0.0045845560389695 0.0799171944477228 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/719 29/18639 0.172413793103448 4.46956980480553 0.00463288083754915 0.0799171944477228 GO:0140313 molecular sequestering activity 7/719 55/18639 0.127272727272727 3.2993551650019 0.00500885062752898 0.0819278959670607 GO:0005126 cytokine receptor binding 20/719 275/18639 0.0727272727272727 1.88534580857251 0.00512434038966528 0.0819278959670607 GO:0031210 phosphatidylcholine binding 5/719 30/18639 0.166666666666667 4.32058414464534 0.00538608455188901 0.0819278959670607 GO:0097110 scaffold protein binding 8/719 70/18639 0.114285714285714 2.96268627061395 0.00540455209593003 0.0819278959670607 GO:1901981 phosphatidylinositol phosphate binding 15/719 185/18639 0.0810810810810811 2.10190580009773 0.00547167799312235 0.0819278959670607 GO:0051020 GTPase binding 22/719 315/18639 0.0698412698412698 1.81053049870852 0.00552274306089224 0.0819278959670607 GO:0005031 tumor necrosis factor receptor activity 3/719 10/18639 0.3 7.77705146036161 0.00559755810955073 0.0819278959670607 GO:0005381 iron ion transmembrane transporter activity 3/719 10/18639 0.3 7.77705146036161 0.00559755810955073 0.0819278959670607 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 3/719 10/18639 0.3 7.77705146036161 0.00559755810955073 0.0819278959670607 GO:0050308 sugar-phosphatase activity 3/719 10/18639 0.3 7.77705146036161 0.00559755810955073 0.0819278959670607 GO:0070325 lipoprotein particle receptor binding 5/719 31/18639 0.161290322580645 4.18121046256001 0.00622182039113006 0.0897056492213678 GO:0002020 protease binding 12/719 136/18639 0.0882352941176471 2.28736807657695 0.00642128853067885 0.0912200694211143 GO:0061134 peptidase regulator activity 17/719 226/18639 0.0752212389380531 1.94999815377799 0.00681504646481883 0.0926112699058614 GO:0031267 small GTPase binding 20/719 283/18639 0.0706713780918728 1.83204981398389 0.00698308743837831 0.0926112699058614 GO:0051082 unfolded protein binding 11/719 121/18639 0.0909090909090909 2.35668226071564 0.00713410352845033 0.0926112699058614 GO:0022884 macromolecule transmembrane transporter activity 5/719 32/18639 0.15625 4.05054763560501 0.007144550499902 0.0926112699058614 GO:0141110 transporter inhibitor activity 6/719 45/18639 0.133333333333333 3.45646731571627 0.00729458035104168 0.0926112699058614 GO:0004879 nuclear receptor activity 7/719 59/18639 0.11864406779661 3.07567006906956 0.00737942403682157 0.0926112699058614 GO:0008199 ferric iron binding 3/719 11/18639 0.272727272727273 7.07004678214692 0.00747792862593912 0.0926112699058614 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/719 11/18639 0.272727272727273 7.07004678214692 0.00747792862593912 0.0926112699058614 GO:0019203 carbohydrate phosphatase activity 3/719 11/18639 0.272727272727273 7.07004678214692 0.00747792862593912 0.0926112699058614 GO:0019864 IgG binding 3/719 11/18639 0.272727272727273 7.07004678214692 0.00747792862593912 0.0926112699058614 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/719 21/18639 0.19047619047619 4.93781045102325 0.00778212778237434 0.0951586764275141 GO:0098531 ligand-modulated transcription factor activity 7/719 60/18639 0.116666666666667 3.02440890125174 0.00808340461697006 0.0972992571305941 GO:0140311 protein sequestering activity 5/719 33/18639 0.151515151515152 3.9278037678594 0.00815863336188212 0.0972992571305941 GO:0072341 modified amino acid binding 9/719 91/18639 0.0989010989010989 2.56386311880053 0.0084327831317635 0.0993422988449212 GO:0015026 coreceptor activity 7/719 61/18639 0.114754098360656 2.97482842746073 0.00883562911329583 0.102833948475226 GO:0004866 endopeptidase inhibitor activity 13/719 161/18639 0.0807453416149068 2.09320225641203 0.00963889417443641 0.108819031876053 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/719 12/18639 0.25 6.48087621696801 0.00968782271360302 0.108819031876053 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/719 12/18639 0.25 6.48087621696801 0.00968782271360302 0.108819031876053 GO:0042826 histone deacetylase binding 11/719 127/18639 0.0866141732283465 2.24534294131175 0.010118025460404 0.112344972353451 GO:0061135 endopeptidase regulator activity 14/719 184/18639 0.0760869565217391 1.97244058777287 0.0121215386249799 0.129908537078906 GO:0005035 death receptor activity 3/719 13/18639 0.230769230769231 5.98234727720124 0.0122377607393172 0.129908537078906 GO:0008035 high-density lipoprotein particle binding 3/719 13/18639 0.230769230769231 5.98234727720124 0.0122377607393172 0.129908537078906 GO:0035673 oligopeptide transmembrane transporter activity 3/719 13/18639 0.230769230769231 5.98234727720124 0.0122377607393172 0.129908537078906 GO:0017124 SH3 domain binding 10/719 115/18639 0.0869565217391304 2.25421781459757 0.0134909476625911 0.141654950457207 GO:0008234 cysteine-type peptidase activity 14/719 187/18639 0.0748663101604278 1.94079715588347 0.013811581360485 0.143462232196005 GO:0030414 peptidase inhibitor activity 13/719 169/18639 0.0769230769230769 1.99411575906708 0.0140628647298663 0.144518375840967 GO:0051087 protein-folding chaperone binding 11/719 134/18639 0.082089552238806 2.12804890706412 0.0147183979086376 0.147685590921488 GO:0042887 amide transmembrane transporter activity 5/719 38/18639 0.131578947368421 3.41098748261474 0.0147426154220963 0.147685590921488 GO:0008191 metalloendopeptidase inhibitor activity 3/719 14/18639 0.214285714285714 5.55503675740115 0.0151354798149351 0.147685590921488 GO:0019763 immunoglobulin receptor activity 3/719 14/18639 0.214285714285714 5.55503675740115 0.0151354798149351 0.147685590921488 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/719 14/18639 0.214285714285714 5.55503675740115 0.0151354798149351 0.147685590921488 GO:0019838 growth factor binding 11/719 136/18639 0.0808823529411765 2.09675407019553 0.016284156896289 0.155154362536156 GO:0044325 transmembrane transporter binding 11/719 136/18639 0.0808823529411765 2.09675407019553 0.016284156896289 0.155154362536156 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 18/719 268/18639 0.0671641791044776 1.74113092396156 0.0163827587771097 0.155154362536156 GO:0008238 exopeptidase activity 9/719 102/18639 0.0882352941176471 2.28736807657695 0.0170232181850886 0.159654648221317 GO:0050997 quaternary ammonium group binding 5/719 40/18639 0.125 3.24043810848401 0.0181522434278378 0.167000639536107 GO:0140662 ATP-dependent protein folding chaperone 5/719 40/18639 0.125 3.24043810848401 0.0181522434278378 0.167000639536107 GO:0005041 low-density lipoprotein particle receptor activity 3/719 15/18639 0.2 5.18470097357441 0.0183861890451514 0.167557156769965 GO:0022804 active transmembrane transporter activity 27/719 457/18639 0.0590809628008753 1.53158562676706 0.0191088776414767 0.172515661697818 GO:0042169 SH2 domain binding 5/719 41/18639 0.121951219512195 3.16140303266732 0.0200366444540695 0.179216653172511 GO:0015923 mannosidase activity 3/719 16/18639 0.1875 4.86065716272601 0.0219928071120821 0.193591660515902 GO:0035198 miRNA binding 5/719 42/18639 0.119047619047619 3.08613153188953 0.0220445990235499 0.193591660515902 GO:0001217 DNA-binding transcription repressor activity 18/719 278/18639 0.0647482014388489 1.67850031518596 0.0227752587041712 0.198206305479544 GO:0061980 regulatory RNA binding 6/719 58/18639 0.103448275862069 2.68174188288332 0.0238587982849357 0.205070447652472 GO:0008200 ion channel inhibitor activity 5/719 43/18639 0.116279069767442 3.01436103114791 0.0241787103060328 0.205070447652472 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 8/719 91/18639 0.0879120879120879 2.27898943893381 0.0242008602819688 0.205070447652472 GO:0001786 phosphatidylserine binding 6/719 59/18639 0.101694915254237 2.63628863063106 0.0257243878224581 0.20894727522926 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/719 59/18639 0.101694915254237 2.63628863063106 0.0257243878224581 0.20894727522926 GO:0015278 intracellularly gated calcium channel activity 3/719 17/18639 0.176470588235294 4.57473615315389 0.0259561832582932 0.20894727522926 GO:0016805 dipeptidase activity 3/719 17/18639 0.176470588235294 4.57473615315389 0.0259561832582932 0.20894727522926 GO:0046965 nuclear retinoid X receptor binding 3/719 17/18639 0.176470588235294 4.57473615315389 0.0259561832582932 0.20894727522926 GO:0070403 NAD+ binding 3/719 17/18639 0.176470588235294 4.57473615315389 0.0259561832582932 0.20894727522926 GO:0016248 channel inhibitor activity 5/719 44/18639 0.113636363636364 2.94585282589455 0.0264413607409133 0.211093838642332 GO:0003714 transcription corepressor activity 14/719 204/18639 0.0686274509803922 1.77906405955985 0.027044549435055 0.213128067447588 GO:0001965 G-protein alpha-subunit binding 4/719 30/18639 0.133333333333333 3.45646731571627 0.0271374247371152 0.213128067447588 GO:0015078 proton transmembrane transporter activity 13/719 185/18639 0.0702702702702703 1.82165169341804 0.0273876369195664 0.213358526325009 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/719 130/18639 0.0769230769230769 1.99411575906708 0.0290517539187178 0.224263668664803 GO:0046982 protein heterodimerization activity 22/719 369/18639 0.0596205962059621 1.54557481597069 0.0294245778849224 0.224263668664803 GO:0005516 calmodulin binding 14/719 207/18639 0.0676328502415459 1.75328052246478 0.0301174765850765 0.224263668664803 GO:0008525 phosphatidylcholine transporter activity 3/719 18/18639 0.166666666666667 4.32058414464534 0.030275302671385 0.224263668664803 GO:0030228 lipoprotein particle receptor activity 3/719 18/18639 0.166666666666667 4.32058414464534 0.030275302671385 0.224263668664803 GO:0070064 proline-rich region binding 3/719 18/18639 0.166666666666667 4.32058414464534 0.030275302671385 0.224263668664803 GO:0031072 heat shock protein binding 10/719 131/18639 0.0763358778625954 1.97889350136428 0.030412567903819 0.224263668664803 GO:0004896 cytokine receptor activity 8/719 96/18639 0.0833333333333333 2.16029207232267 0.032021791096151 0.234341289385469 GO:0042626 ATPase-coupled transmembrane transporter activity 8/719 98/18639 0.0816326530612245 2.11620447900996 0.0355836908452472 0.258449965086532 GO:0140693 molecular condensate scaffold activity 5/719 48/18639 0.104166666666667 2.70036509040334 0.0368170945707574 0.26429088588416 GO:0071889 14-3-3 protein binding 4/719 33/18639 0.121212121212121 3.14224301428752 0.037034979091137 0.26429088588416 GO:1990782 protein tyrosine kinase binding 9/719 117/18639 0.0769230769230769 1.99411575906708 0.0372086547414552 0.26429088588416 GO:0120013 lipid transfer activity 6/719 65/18639 0.0923076923076923 2.3929389108805 0.0389552891079882 0.274677439987712 GO:0035254 glutamate receptor binding 5/719 49/18639 0.102040816326531 2.64525559876245 0.0397502433002237 0.278251703101566 GO:0051427 hormone receptor binding 4/719 34/18639 0.117647058823529 3.04982410210259 0.0407372020403082 0.283108900510343 GO:0140658 ATP-dependent chromatin remodeler activity 11/719 158/18639 0.069620253164557 1.80480097181388 0.0426187221996181 0.294069183177365 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 9/719 122/18639 0.0737704918032787 1.91238970336761 0.0465530307666921 0.318937785252657 GO:0030145 manganese ion binding 6/719 68/18639 0.0882352941176471 2.28736807657695 0.0469375131976442 0.319307308091016 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 7/719 86/18639 0.0813953488372093 2.11005272180354 0.0481999514269504 0.32476273150559 GO:0005539 glycosaminoglycan binding 15/719 242/18639 0.0619834710743802 1.6068288141243 0.0487057131362856 0.32476273150559 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/719 36/18639 0.111111111111111 2.88038942976356 0.048748029056222 0.32476273150559 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/719 22/18639 0.136363636363636 3.53502339107346 0.0510339774626728 0.33536613761185 GO:0140517 protein-RNA adaptor activity 3/719 22/18639 0.136363636363636 3.53502339107346 0.0510339774626728 0.33536613761185 GO:1901505 carbohydrate derivative transmembrane transporter activity 5/719 53/18639 0.0943396226415094 2.44561366678038 0.0528701023817375 0.33936576130705 GO:0008239 dipeptidyl-peptidase activity 2/719 10/18639 0.2 5.18470097357441 0.0544530983463694 0.33936576130705 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/719 10/18639 0.2 5.18470097357441 0.0544530983463694 0.33936576130705 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/719 10/18639 0.2 5.18470097357441 0.0544530983463694 0.33936576130705 GO:0030957 Tat protein binding 2/719 10/18639 0.2 5.18470097357441 0.0544530983463694 0.33936576130705 GO:0035256 G protein-coupled glutamate receptor binding 2/719 10/18639 0.2 5.18470097357441 0.0544530983463694 0.33936576130705 GO:0043422 protein kinase B binding 2/719 10/18639 0.2 5.18470097357441 0.0544530983463694 0.33936576130705 GO:1905394 retromer complex binding 2/719 10/18639 0.2 5.18470097357441 0.0544530983463694 0.33936576130705 GO:0015399 primary active transmembrane transporter activity 11/719 166/18639 0.0662650602409639 1.71782261172646 0.0570416863886467 0.348884677284673 GO:0004602 glutathione peroxidase activity 3/719 23/18639 0.130434782608696 3.38132672189635 0.0570639534275137 0.348884677284673 GO:0005158 insulin receptor binding 3/719 23/18639 0.130434782608696 3.38132672189635 0.0570639534275137 0.348884677284673 GO:0005518 collagen binding 6/719 72/18639 0.0833333333333333 2.16029207232267 0.0590495018643986 0.358753577364837 GO:0035591 signaling adaptor activity 9/719 129/18639 0.0697674418604651 1.80861661868875 0.0620708658589011 0.368405128461833 GO:0004622 lysophospholipase activity 3/719 24/18639 0.125 3.24043810848401 0.0634142028410367 0.368405128461833 GO:0050699 WW domain binding 3/719 24/18639 0.125 3.24043810848401 0.0634142028410367 0.368405128461833 GO:0070840 dynein complex binding 3/719 24/18639 0.125 3.24043810848401 0.0634142028410367 0.368405128461833 GO:0019902 phosphatase binding 12/719 190/18639 0.0631578947368421 1.63727399165508 0.0647774774109328 0.368405128461833 GO:0001851 complement component C3b binding 2/719 11/18639 0.181818181818182 4.71336452143128 0.0648920249509095 0.368405128461833 GO:0140031 phosphorylation-dependent protein binding 2/719 11/18639 0.181818181818182 4.71336452143128 0.0648920249509095 0.368405128461833 GO:1902936 phosphatidylinositol bisphosphate binding 8/719 111/18639 0.0720720720720721 1.86836071119798 0.0652683947694594 0.368405128461833 GO:0141108 transporter regulator activity 11/719 170/18639 0.0647058823529412 1.67740325615643 0.0653389357306879 0.368405128461833 GO:0004177 aminopeptidase activity 4/719 40/18639 0.1 2.5923504867872 0.0671703898430595 0.368405128461833 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/719 40/18639 0.1 2.5923504867872 0.0671703898430595 0.368405128461833 GO:0000510 H3-H4 histone complex chaperone activity 10/719 151/18639 0.0662251655629139 1.71678840184583 0.0676806385748163 0.368405128461833 GO:0140584 chromatin extrusion motor activity 10/719 151/18639 0.0662251655629139 1.71678840184583 0.0676806385748163 0.368405128461833 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 10/719 151/18639 0.0662251655629139 1.71678840184583 0.0676806385748163 0.368405128461833 GO:0140849 ATP-dependent H2AZ histone chaperone activity 10/719 151/18639 0.0662251655629139 1.71678840184583 0.0676806385748163 0.368405128461833 GO:0003725 double-stranded RNA binding 6/719 75/18639 0.08 2.07388038942976 0.0692480757321951 0.368405128461833 GO:0019003 GDP binding 6/719 75/18639 0.08 2.07388038942976 0.0692480757321951 0.368405128461833 GO:0008201 heparin binding 11/719 172/18639 0.063953488372093 1.65789856713135 0.069766646027393 0.368405128461833 GO:0001848 complement binding 3/719 25/18639 0.12 3.11082058414465 0.0700752893110476 0.368405128461833 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/719 25/18639 0.12 3.11082058414465 0.0700752893110476 0.368405128461833 GO:0042974 nuclear retinoic acid receptor binding 3/719 25/18639 0.12 3.11082058414465 0.0700752893110476 0.368405128461833 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/719 25/18639 0.12 3.11082058414465 0.0700752893110476 0.368405128461833 GO:0015616 DNA translocase activity 10/719 152/18639 0.0657894736842105 1.70549374130737 0.0700800220205164 0.368405128461833 GO:0140674 ATP-dependent histone chaperone activity 10/719 152/18639 0.0657894736842105 1.70549374130737 0.0700800220205164 0.368405128461833 GO:0042287 MHC protein binding 4/719 41/18639 0.0975609756097561 2.52912242613386 0.0722659298851125 0.368405128461833 GO:0140318 protein transporter activity 4/719 41/18639 0.0975609756097561 2.52912242613386 0.0722659298851125 0.368405128461833 GO:0061775 cohesin loader activity 10/719 153/18639 0.065359477124183 1.69434672339033 0.0725326047700061 0.368405128461833 GO:0016208 AMP binding 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0016801 hydrolase activity, acting on ether bonds 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0016803 ether hydrolase activity 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0034452 dynactin binding 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0070008 serine-type exopeptidase activity 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:1990459 transferrin receptor binding 2/719 12/18639 0.166666666666667 4.32058414464534 0.0759328653983707 0.368405128461833 GO:0004529 DNA exonuclease activity 3/719 26/18639 0.115384615384615 2.99117363860062 0.0770370972559942 0.368405128461833 GO:0008198 ferrous iron binding 3/719 26/18639 0.115384615384615 2.99117363860062 0.0770370972559942 0.368405128461833 GO:0019865 immunoglobulin binding 3/719 26/18639 0.115384615384615 2.99117363860062 0.0770370972559942 0.368405128461833 GO:0030247 polysaccharide binding 3/719 26/18639 0.115384615384615 2.99117363860062 0.0770370972559942 0.368405128461833 GO:0050681 nuclear androgen receptor binding 3/719 26/18639 0.115384615384615 2.99117363860062 0.0770370972559942 0.368405128461833 GO:0070006 metalloaminopeptidase activity 3/719 26/18639 0.115384615384615 2.99117363860062 0.0770370972559942 0.368405128461833 GO:0008375 acetylglucosaminyltransferase activity 4/719 43/18639 0.0930232558139535 2.41148882491833 0.0830266088893021 0.39504589373634 GO:0016922 nuclear receptor binding 9/719 137/18639 0.0656934306569343 1.70300396942225 0.0834258409132644 0.39504589373634 GO:0004364 glutathione transferase activity 3/719 27/18639 0.111111111111111 2.88038942976356 0.0842889337783136 0.395257815678888 GO:0035255 ionotropic glutamate receptor binding 3/719 27/18639 0.111111111111111 2.88038942976356 0.0842889337783136 0.395257815678888 GO:0005172 vascular endothelial growth factor receptor binding 2/719 13/18639 0.153846153846154 3.98823151813416 0.0875137935181986 0.404489591093684 GO:0005542 folic acid binding 2/719 13/18639 0.153846153846154 3.98823151813416 0.0875137935181986 0.404489591093684 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/719 13/18639 0.153846153846154 3.98823151813416 0.0875137935181986 0.404489591093684 GO:0140767 enzyme-substrate adaptor activity 9/719 139/18639 0.0647482014388489 1.67850031518596 0.089376822678197 0.408745415627239 GO:0015179 L-amino acid transmembrane transporter activity 5/719 62/18639 0.0806451612903226 2.09060523128 0.0905107238733647 0.408745415627239 GO:0015291 secondary active transmembrane transporter activity 16/719 287/18639 0.0557491289198606 1.44521281493363 0.0905583303069156 0.408745415627239 GO:0003689 DNA clamp loader activity 10/719 160/18639 0.0625 1.620219054242 0.0911988406506522 0.408745415627239 GO:0099106 ion channel regulator activity 10/719 160/18639 0.0625 1.620219054242 0.0911988406506522 0.408745415627239 GO:0046625 sphingolipid binding 3/719 28/18639 0.107142857142857 2.77751837870058 0.0918196223510463 0.408745415627239 GO:0051019 mitogen-activated protein kinase binding 3/719 28/18639 0.107142857142857 2.77751837870058 0.0918196223510463 0.408745415627239 GO:0097718 disordered domain specific binding 3/719 28/18639 0.107142857142857 2.77751837870058 0.0918196223510463 0.408745415627239 GO:0005178 integrin binding 10/719 161/18639 0.062111801242236 1.61015558185541 0.0940798657105774 0.415047167326808 GO:0004715 non-membrane spanning protein tyrosine kinase activity 4/719 45/18639 0.0888888888888889 2.30431154381085 0.0945241995982379 0.415047167326808 GO:0046915 transition metal ion transmembrane transporter activity 4/719 45/18639 0.0888888888888889 2.30431154381085 0.0945241995982379 0.415047167326808 GO:0005161 platelet-derived growth factor receptor binding 2/719 14/18639 0.142857142857143 3.70335783826744 0.0995768458020759 0.425799074455689 GO:0005545 1-phosphatidylinositol binding 2/719 14/18639 0.142857142857143 3.70335783826744 0.0995768458020759 0.425799074455689 GO:0042043 neurexin family protein binding 2/719 14/18639 0.142857142857143 3.70335783826744 0.0995768458020759 0.425799074455689 GO:0043236 laminin binding 3/719 29/18639 0.103448275862069 2.68174188288332 0.0996175888478113 0.425799074455689 GO:0051861 glycolipid binding 3/719 29/18639 0.103448275862069 2.68174188288332 0.0996175888478113 0.425799074455689 GO:0099604 ligand-gated calcium channel activity 3/719 29/18639 0.103448275862069 2.68174188288332 0.0996175888478113 0.425799074455689 GO:0004180 carboxypeptidase activity 4/719 46/18639 0.0869565217391304 2.25421781459757 0.10053977254346 0.427847666418423 GO:0140713 histone chaperone activity 10/719 164/18639 0.0609756097560976 1.58070151633366 0.103043473534095 0.436578927341824 GO:0051117 ATPase binding 6/719 84/18639 0.0714285714285714 1.85167891913372 0.105519528875879 0.445117313948031 GO:0140359 ABC-type transporter activity 4/719 47/18639 0.0851063829787234 2.20625573343592 0.106727566403459 0.446395401036625 GO:0001968 fibronectin binding 3/719 30/18639 0.1 2.5923504867872 0.107670940415666 0.446395401036625 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/719 30/18639 0.1 2.5923504867872 0.107670940415666 0.446395401036625 GO:0031624 ubiquitin conjugating enzyme binding 3/719 30/18639 0.1 2.5923504867872 0.107670940415666 0.446395401036625 GO:0008235 metalloexopeptidase activity 5/719 66/18639 0.0757575757575758 1.9639018839297 0.110718327336952 0.447344684817815 GO:0046943 carboxylic acid transmembrane transporter activity 11/719 188/18639 0.0585106382978723 1.51680081673719 0.112012529219016 0.447344684817815 GO:0000774 adenyl-nucleotide exchange factor activity 2/719 15/18639 0.133333333333333 3.45646731571627 0.112067716072372 0.447344684817815 GO:0004559 alpha-mannosidase activity 2/719 15/18639 0.133333333333333 3.45646731571627 0.112067716072372 0.447344684817815 GO:0015929 hexosaminidase activity 2/719 15/18639 0.133333333333333 3.45646731571627 0.112067716072372 0.447344684817815 GO:0016846 carbon-sulfur lyase activity 2/719 15/18639 0.133333333333333 3.45646731571627 0.112067716072372 0.447344684817815 GO:0034483 heparan sulfate sulfotransferase activity 2/719 15/18639 0.133333333333333 3.45646731571627 0.112067716072372 0.447344684817815 GO:0047372 monoacylglycerol lipase activity 2/719 15/18639 0.133333333333333 3.45646731571627 0.112067716072372 0.447344684817815 GO:0140776 protein-containing complex destabilizing activity 2/719 15/18639 0.133333333333333 3.45646731571627 0.112067716072372 0.447344684817815 GO:0016209 antioxidant activity 6/719 86/18639 0.0697674418604651 1.80861661868875 0.114700231724519 0.45035345790541 GO:0005342 organic acid transmembrane transporter activity 11/719 189/18639 0.0582010582010582 1.50877541559044 0.115055537910428 0.45035345790541 GO:0016247 channel regulator activity 10/719 168/18639 0.0595238095238095 1.54306576594476 0.115737146341248 0.45035345790541 GO:0047499 calcium-independent phospholipase A2 activity 3/719 31/18639 0.0967741935483871 2.508726277536 0.115967537661448 0.45035345790541 GO:0072349 modified amino acid transmembrane transporter activity 3/719 31/18639 0.0967741935483871 2.508726277536 0.115967537661448 0.45035345790541 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/719 67/18639 0.0746268656716418 1.93458991551284 0.116084897534624 0.45035345790541 GO:0050840 extracellular matrix binding 5/719 67/18639 0.0746268656716418 1.93458991551284 0.116084897534624 0.45035345790541 GO:0031490 chromatin DNA binding 8/719 128/18639 0.0625 1.620219054242 0.12204375978617 0.467781981249734 GO:0005159 insulin-like growth factor receptor binding 2/719 16/18639 0.125 3.24043810848401 0.124935560209556 0.467781981249734 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/719 16/18639 0.125 3.24043810848401 0.124935560209556 0.467781981249734 GO:0005521 lamin binding 2/719 16/18639 0.125 3.24043810848401 0.124935560209556 0.467781981249734 GO:0016722 oxidoreductase activity, acting on metal ions 2/719 16/18639 0.125 3.24043810848401 0.124935560209556 0.467781981249734 GO:0022858 alanine transmembrane transporter activity 2/719 16/18639 0.125 3.24043810848401 0.124935560209556 0.467781981249734 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/719 16/18639 0.125 3.24043810848401 0.124935560209556 0.467781981249734 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/719 16/18639 0.125 3.24043810848401 0.124935560209556 0.467781981249734 GO:0140328 floppase activity 2/719 16/18639 0.125 3.24043810848401 0.124935560209556 0.467781981249734 GO:0032813 tumor necrosis factor receptor superfamily binding 4/719 50/18639 0.08 2.07388038942976 0.12627806633507 0.470983058222695 GO:0004857 enzyme inhibitor activity 21/719 416/18639 0.0504807692307692 1.30863846688777 0.127536232782229 0.473846157183205 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/719 89/18639 0.0674157303370786 1.74765201356441 0.129195696738807 0.476347492556061 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/719 89/18639 0.0674157303370786 1.74765201356441 0.129195696738807 0.476347492556061 GO:0016887 ATP hydrolysis activity 21/719 417/18639 0.0503597122302158 1.30550024514464 0.129722678384665 0.476471890948998 GO:0061659 ubiquitin-like protein ligase activity 19/719 372/18639 0.0510752688172043 1.32404997981067 0.131071025576933 0.479600798133778 GO:0003743 translation initiation factor activity 4/719 51/18639 0.0784313725490196 2.0332160680684 0.133107562231688 0.482063192538666 GO:0030544 Hsp70 protein binding 4/719 51/18639 0.0784313725490196 2.0332160680684 0.133107562231688 0.482063192538666 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/719 33/18639 0.0909090909090909 2.35668226071564 0.133241068745159 0.482063192538666 GO:0140793 histone H2AXY142 phosphatase activity 6/719 90/18639 0.0666666666666667 1.72823365785814 0.134214817162279 0.483774303652094 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/719 17/18639 0.117647058823529 3.04982410210259 0.138132810469725 0.490574613653507 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/719 17/18639 0.117647058823529 3.04982410210259 0.138132810469725 0.490574613653507 GO:0008429 phosphatidylethanolamine binding 2/719 17/18639 0.117647058823529 3.04982410210259 0.138132810469725 0.490574613653507 GO:0019198 transmembrane receptor protein phosphatase activity 2/719 17/18639 0.117647058823529 3.04982410210259 0.138132810469725 0.490574613653507 GO:0022832 voltage-gated channel activity 10/719 175/18639 0.0571428571428571 1.48134313530697 0.139946525351551 0.494096784590588 GO:0061630 ubiquitin protein ligase activity 18/719 353/18639 0.0509915014164306 1.32187843518894 0.140147535173728 0.494096784590588 GO:0090482 vitamin transmembrane transporter activity 3/719 34/18639 0.0882352941176471 2.28736807657695 0.142193055845629 0.499485425261372 GO:0004623 phospholipase A2 activity 3/719 35/18639 0.0857142857142857 2.22201470296046 0.151338499453144 0.517526816185171 GO:0000900 mRNA regulatory element binding translation repressor activity 2/719 18/18639 0.111111111111111 2.88038942976356 0.151614998944517 0.517526816185171 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/719 18/18639 0.111111111111111 2.88038942976356 0.151614998944517 0.517526816185171 GO:0008409 5'-3' exonuclease activity 2/719 18/18639 0.111111111111111 2.88038942976356 0.151614998944517 0.517526816185171 GO:0015172 acidic amino acid transmembrane transporter activity 2/719 18/18639 0.111111111111111 2.88038942976356 0.151614998944517 0.517526816185171 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/719 18/18639 0.111111111111111 2.88038942976356 0.151614998944517 0.517526816185171 GO:0032393 MHC class I receptor activity 2/719 18/18639 0.111111111111111 2.88038942976356 0.151614998944517 0.517526816185171 GO:0035615 clathrin adaptor activity 2/719 18/18639 0.111111111111111 2.88038942976356 0.151614998944517 0.517526816185171 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/719 54/18639 0.0740740740740741 1.92025961984237 0.154460765175563 0.523540698805592 GO:0051287 NAD binding 4/719 54/18639 0.0740740740740741 1.92025961984237 0.154460765175563 0.523540698805592 GO:0042562 hormone binding 6/719 94/18639 0.0638297872340425 1.65469180007694 0.155183365634655 0.524150808402367 GO:0001221 transcription coregulator binding 7/719 115/18639 0.0608695652173913 1.5779524702183 0.156332154467337 0.526191154060791 GO:0048029 monosaccharide binding 5/719 74/18639 0.0675675675675676 1.75158816674811 0.156899589870645 0.526267374357787 GO:0008514 organic anion transmembrane transporter activity 14/719 269/18639 0.0520446096654275 1.34917869200821 0.158745524908199 0.530616529623947 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/719 36/18639 0.0833333333333333 2.16029207232267 0.160664905852864 0.535180341565057 GO:0015294 solute:monoatomic cation symporter activity 7/719 116/18639 0.0603448275862069 1.56434943168193 0.161244395384684 0.535264900142973 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/719 19/18639 0.105263157894737 2.72878998609179 0.165340589735902 0.537774443383438 GO:0015245 fatty acid transmembrane transporter activity 2/719 19/18639 0.105263157894737 2.72878998609179 0.165340589735902 0.537774443383438 GO:0046624 sphingolipid transporter activity 2/719 19/18639 0.105263157894737 2.72878998609179 0.165340589735902 0.537774443383438 GO:0050145 nucleoside monophosphate kinase activity 2/719 19/18639 0.105263157894737 2.72878998609179 0.165340589735902 0.537774443383438 GO:0097001 ceramide binding 2/719 19/18639 0.105263157894737 2.72878998609179 0.165340589735902 0.537774443383438 GO:1990380 K48-linked deubiquitinase activity 2/719 19/18639 0.105263157894737 2.72878998609179 0.165340589735902 0.537774443383438 GO:0070851 growth factor receptor binding 8/719 139/18639 0.0575539568345324 1.4920002801653 0.169186565815382 0.547168564844224 GO:0170055 lipid transmembrane transporter activity 4/719 56/18639 0.0714285714285714 1.85167891913372 0.16936169864226 0.547168564844224 GO:0016791 phosphatase activity 14/719 273/18639 0.0512820512820513 1.32941050604472 0.17156827986045 0.552449861150648 GO:0004713 protein tyrosine kinase activity 8/719 140/18639 0.0571428571428571 1.48134313530697 0.173837624032147 0.556671057018068 GO:0008083 growth factor activity 9/719 162/18639 0.0555555555555556 1.44019471488178 0.174771679893778 0.556671057018068 GO:0001664 G protein-coupled receptor binding 15/719 297/18639 0.0505050505050505 1.3092679226198 0.17539638063626 0.556671057018068 GO:0003724 RNA helicase activity 5/719 77/18639 0.0649350649350649 1.68334447193974 0.175973869748391 0.556671057018068 GO:0004601 peroxidase activity 4/719 57/18639 0.0701754385964912 1.8191933240612 0.176994791214411 0.556671057018068 GO:0015932 nucleobase-containing compound transmembrane transporter activity 4/719 57/18639 0.0701754385964912 1.8191933240612 0.176994791214411 0.556671057018068 GO:0016504 peptidase activator activity 4/719 57/18639 0.0701754385964912 1.8191933240612 0.176994791214411 0.556671057018068 GO:0004725 protein tyrosine phosphatase activity 6/719 98/18639 0.0612244897959184 1.58715335925747 0.1774893225275 0.556671057018068 GO:0001614 purinergic nucleotide receptor activity 2/719 20/18639 0.1 2.5923504867872 0.179270819437611 0.558631005086233 GO:0016502 nucleotide receptor activity 2/719 20/18639 0.1 2.5923504867872 0.179270819437611 0.558631005086233 GO:0032182 ubiquitin-like protein binding 7/719 120/18639 0.0583333333333333 1.51220445062587 0.181567362668478 0.563968078256429 GO:0043130 ubiquitin binding 6/719 100/18639 0.06 1.55541029207232 0.189103122194883 0.576527719090556 GO:0008186 ATP-dependent activity, acting on RNA 5/719 79/18639 0.0632911392405063 1.64072815619443 0.189154420948897 0.576527719090556 GO:0008094 ATP-dependent activity, acting on DNA 11/719 210/18639 0.0523809523809524 1.35789787403139 0.189273949492856 0.576527719090556 GO:0140597 protein carrier chaperone 10/719 188/18639 0.0531914893617021 1.37890983339745 0.191203718732753 0.576527719090556 GO:0031593 polyubiquitin modification-dependent protein binding 4/719 59/18639 0.0677966101694915 1.75752575375404 0.192597249166431 0.576527719090556 GO:0036002 pre-mRNA binding 4/719 59/18639 0.0677966101694915 1.75752575375404 0.192597249166431 0.576527719090556 GO:0019903 protein phosphatase binding 8/719 144/18639 0.0555555555555556 1.44019471488178 0.192996953398078 0.576527719090556 GO:0001846 opsonin binding 2/719 21/18639 0.0952380952380952 2.46890522551162 0.193369545533478 0.576527719090556 GO:0005123 death receptor binding 2/719 21/18639 0.0952380952380952 2.46890522551162 0.193369545533478 0.576527719090556 GO:0005248 voltage-gated sodium channel activity 2/719 21/18639 0.0952380952380952 2.46890522551162 0.193369545533478 0.576527719090556 GO:0008373 sialyltransferase activity 2/719 21/18639 0.0952380952380952 2.46890522551162 0.193369545533478 0.576527719090556 GO:0019200 carbohydrate kinase activity 2/719 21/18639 0.0952380952380952 2.46890522551162 0.193369545533478 0.576527719090556 GO:0140312 cargo adaptor activity 2/719 21/18639 0.0952380952380952 2.46890522551162 0.193369545533478 0.576527719090556 GO:0030246 carbohydrate binding 14/719 280/18639 0.05 1.2961752433936 0.195209764779939 0.580223485468987 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/719 60/18639 0.0666666666666667 1.72823365785814 0.200554914175337 0.59378226650421 GO:0015171 amino acid transmembrane transporter activity 6/719 102/18639 0.0588235294117647 1.5249120510513 0.201000829344593 0.59378226650421 GO:0030971 receptor tyrosine kinase binding 5/719 81/18639 0.0617283950617284 1.60021634986864 0.202674928621032 0.595730163618937 GO:0015293 symporter activity 8/719 146/18639 0.0547945205479452 1.42046602015737 0.202893606449928 0.595730163618937 GO:0008970 phospholipase A1 activity 2/719 22/18639 0.0909090909090909 2.35668226071564 0.207603102340559 0.607710899578727 GO:0019905 syntaxin binding 4/719 61/18639 0.0655737704918033 1.69990195854899 0.208609040238384 0.607973372423961 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/719 41/18639 0.0731707317073171 1.89684181960039 0.209580883040558 0.607973372423961 GO:0017080 sodium channel regulator activity 3/719 41/18639 0.0731707317073171 1.89684181960039 0.209580883040558 0.607973372423961 GO:0008135 translation factor activity, RNA binding 5/719 83/18639 0.0602409638554217 1.56165691975133 0.21650758559845 0.626186609844619 GO:0042056 chemoattractant activity 3/719 42/18639 0.0714285714285714 1.85167891913372 0.219736921292503 0.628721989914898 GO:0048487 beta-tubulin binding 3/719 42/18639 0.0714285714285714 1.85167891913372 0.219736921292503 0.628721989914898 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/719 23/18639 0.0869565217391304 2.25421781459757 0.221940164141801 0.628721989914898 GO:0008171 O-methyltransferase activity 2/719 23/18639 0.0869565217391304 2.25421781459757 0.221940164141801 0.628721989914898 GO:0016849 phosphorus-oxygen lyase activity 2/719 23/18639 0.0869565217391304 2.25421781459757 0.221940164141801 0.628721989914898 GO:0140103 catalytic activity, acting on a glycoprotein 2/719 23/18639 0.0869565217391304 2.25421781459757 0.221940164141801 0.628721989914898 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/719 23/18639 0.0869565217391304 2.25421781459757 0.221940164141801 0.628721989914898 GO:0004527 exonuclease activity 5/719 84/18639 0.0595238095238095 1.54306576594476 0.223532146150512 0.62923908596085 GO:0180051 translation factor activity 5/719 84/18639 0.0595238095238095 1.54306576594476 0.223532146150512 0.62923908596085 GO:0005507 copper ion binding 4/719 63/18639 0.0634920634920635 1.64593681700775 0.224983184182095 0.62923908596085 GO:0005244 voltage-gated monoatomic ion channel activity 9/719 173/18639 0.0520231213872832 1.34862164052514 0.225379631203368 0.62923908596085 GO:0140030 modification-dependent protein binding 9/719 173/18639 0.0520231213872832 1.34862164052514 0.225379631203368 0.62923908596085 GO:0048156 tau protein binding 3/719 43/18639 0.0697674418604651 1.80861661868875 0.229990194722743 0.640260887902506 GO:0004536 DNA nuclease activity 4/719 64/18639 0.0625 1.620219054242 0.233291495337291 0.646786572955787 GO:0005315 phosphate transmembrane transporter activity 2/719 24/18639 0.0833333333333333 2.16029207232267 0.236351615169144 0.646786572955787 GO:0005540 hyaluronic acid binding 2/719 24/18639 0.0833333333333333 2.16029207232267 0.236351615169144 0.646786572955787 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/719 24/18639 0.0833333333333333 2.16029207232267 0.236351615169144 0.646786572955787 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/719 24/18639 0.0833333333333333 2.16029207232267 0.236351615169144 0.646786572955787 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/719 24/18639 0.0833333333333333 2.16029207232267 0.236351615169144 0.646786572955787 GO:0042578 phosphoric ester hydrolase activity 17/719 363/18639 0.046831955922865 1.21404843733836 0.239117006644014 0.652130290423462 GO:0001046 core promoter sequence-specific DNA binding 3/719 44/18639 0.0681818181818182 1.76751169553673 0.240329589431421 0.652130290423462 GO:0019205 nucleobase-containing compound kinase activity 3/719 44/18639 0.0681818181818182 1.76751169553673 0.240329589431421 0.652130290423462 GO:0004620 phospholipase activity 6/719 109/18639 0.055045871559633 1.42698191933241 0.244610310563342 0.660519701182794 GO:0016829 lyase activity 10/719 200/18639 0.05 1.2961752433936 0.244788874765466 0.660519701182794 GO:0004386 helicase activity 8/719 155/18639 0.0516129032258065 1.3379873480192 0.249735761149641 0.661975059085991 GO:0005319 lipid transporter activity 9/719 178/18639 0.050561797752809 1.31073901017331 0.250036684989014 0.661975059085991 GO:0008009 chemokine activity 3/719 45/18639 0.0666666666666667 1.72823365785814 0.250744260133791 0.661975059085991 GO:0003707 nuclear steroid receptor activity 2/719 25/18639 0.08 2.07388038942976 0.250810426113326 0.661975059085991 GO:0005251 delayed rectifier potassium channel activity 2/719 25/18639 0.08 2.07388038942976 0.250810426113326 0.661975059085991 GO:0015662 P-type ion transporter activity 2/719 25/18639 0.08 2.07388038942976 0.250810426113326 0.661975059085991 GO:0017025 TBP-class protein binding 2/719 25/18639 0.08 2.07388038942976 0.250810426113326 0.661975059085991 GO:0140358 P-type transmembrane transporter activity 2/719 25/18639 0.08 2.07388038942976 0.250810426113326 0.661975059085991 GO:0140104 molecular carrier activity 12/719 249/18639 0.0481927710843374 1.24932553580106 0.255243751650897 0.671840501620617 GO:0003727 single-stranded RNA binding 5/719 89/18639 0.0561797752808989 1.45637667797034 0.259594413623112 0.68143533576067 GO:1901681 sulfur compound binding 13/719 275/18639 0.0472727272727273 1.22547477557213 0.265241254957146 0.685218247589541 GO:0001637 G protein-coupled chemoattractant receptor activity 2/719 26/18639 0.0769230769230769 1.99411575906708 0.265291536851437 0.685218247589541 GO:0004950 chemokine receptor activity 2/719 26/18639 0.0769230769230769 1.99411575906708 0.265291536851437 0.685218247589541 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/719 26/18639 0.0769230769230769 1.99411575906708 0.265291536851437 0.685218247589541 GO:0015216 purine nucleotide transmembrane transporter activity 2/719 26/18639 0.0769230769230769 1.99411575906708 0.265291536851437 0.685218247589541 GO:0052742 phosphatidylinositol kinase activity 2/719 26/18639 0.0769230769230769 1.99411575906708 0.265291536851437 0.685218247589541 GO:1990841 promoter-specific chromatin binding 4/719 68/18639 0.0588235294117647 1.5249120510513 0.267198009371453 0.688302072140862 GO:0001784 phosphotyrosine residue binding 3/719 47/18639 0.0638297872340425 1.65469180007694 0.271757466392485 0.691133807192506 GO:0043495 protein-membrane adaptor activity 3/719 47/18639 0.0638297872340425 1.65469180007694 0.271757466392485 0.691133807192506 GO:0061749 forked DNA-dependent helicase activity 3/719 47/18639 0.0638297872340425 1.65469180007694 0.271757466392485 0.691133807192506 GO:1990518 single-stranded 3'-5' DNA helicase activity 3/719 47/18639 0.0638297872340425 1.65469180007694 0.271757466392485 0.691133807192506 GO:0140789 histone phosphatase activity 7/719 136/18639 0.0514705882352941 1.33429804466988 0.271874582539495 0.691133807192506 GO:0003712 transcription coregulator activity 22/719 495/18639 0.0444444444444444 1.15215577190542 0.276837796684046 0.700832506532563 GO:0015079 potassium ion transmembrane transporter activity 8/719 160/18639 0.05 1.2961752433936 0.277140804860703 0.700832506532563 GO:0008320 protein transmembrane transporter activity 2/719 27/18639 0.0740740740740741 1.92025961984237 0.279771745097287 0.703800796260363 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/719 27/18639 0.0740740740740741 1.92025961984237 0.279771745097287 0.703800796260363 GO:0009378 four-way junction helicase activity 3/719 48/18639 0.0625 1.620219054242 0.282335759895798 0.704745075088737 GO:0036121 double-stranded DNA helicase activity 3/719 48/18639 0.0625 1.620219054242 0.282335759895798 0.704745075088737 GO:0043138 3'-5' DNA helicase activity 3/719 48/18639 0.0625 1.620219054242 0.282335759895798 0.704745075088737 GO:0046875 ephrin receptor binding 2/719 28/18639 0.0714285714285714 1.85167891913372 0.294229600693151 0.727402859426568 GO:0046966 nuclear thyroid hormone receptor binding 2/719 28/18639 0.0714285714285714 1.85167891913372 0.294229600693151 0.727402859426568 GO:0050698 proteoglycan sulfotransferase activity 2/719 28/18639 0.0714285714285714 1.85167891913372 0.294229600693151 0.727402859426568 GO:0004175 endopeptidase activity 18/719 405/18639 0.0444444444444444 1.15215577190542 0.301970273962397 0.727402859426568 GO:0022853 active monoatomic ion transmembrane transporter activity 6/719 118/18639 0.0508474576271186 1.31814431531553 0.30412800587537 0.727402859426568 GO:0004867 serine-type endopeptidase inhibitor activity 5/719 95/18639 0.0526315789473684 1.3643949930459 0.304464552549811 0.727402859426568 GO:0003785 actin monomer binding 2/719 29/18639 0.0689655172413793 1.78782792192221 0.308645305274288 0.727402859426568 GO:0106222 lncRNA binding 2/719 29/18639 0.0689655172413793 1.78782792192221 0.308645305274288 0.727402859426568 GO:0005021 vascular endothelial growth factor receptor activity 3/719 51/18639 0.0588235294117647 1.5249120510513 0.314242414075631 0.727402859426568 GO:0005272 sodium channel activity 3/719 51/18639 0.0588235294117647 1.5249120510513 0.314242414075631 0.727402859426568 GO:0022843 voltage-gated monoatomic cation channel activity 7/719 143/18639 0.048951048951049 1.26898275576996 0.31465854344421 0.727402859426568 GO:0019207 kinase regulator activity 13/719 287/18639 0.0452961672473868 1.17423541213358 0.316209226130416 0.727402859426568 GO:0140097 catalytic activity, acting on DNA 15/719 336/18639 0.0446428571428571 1.15729932445857 0.317780484081077 0.727402859426568 GO:0015215 nucleotide transmembrane transporter activity 2/719 30/18639 0.0666666666666667 1.72823365785814 0.323000617049903 0.727402859426568 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/719 30/18639 0.0666666666666667 1.72823365785814 0.323000617049903 0.727402859426568 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0003796 lysozyme activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0004090 carbonyl reductase (NADPH) activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0005337 nucleoside transmembrane transporter activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0005345 purine nucleobase transmembrane transporter activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0005522 profilin binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0005528 FK506 binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0008140 cAMP response element binding protein binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0015187 glycine transmembrane transporter activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0015203 polyamine transmembrane transporter activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0015279 store-operated calcium channel activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0031419 cobalamin binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0031996 thioesterase binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0035374 chondroitin sulfate binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0042975 peroxisome proliferator activated receptor binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0043121 neurotrophin binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0043208 glycosphingolipid binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0043295 glutathione binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0070513 death domain binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0071723 lipopeptide binding 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/719 10/18639 0.1 2.5923504867872 0.325298173159707 0.727402859426568 GO:0005249 voltage-gated potassium channel activity 5/719 98/18639 0.0510204081632653 1.32262779938123 0.327331028404603 0.730138823379703 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6/719 122/18639 0.0491803278688525 1.27492646891174 0.331398322625277 0.730138823379703 GO:0008146 sulfotransferase activity 3/719 53/18639 0.0566037735849057 1.46736820006823 0.33556717300696 0.730138823379703 GO:0051018 protein kinase A binding 3/719 53/18639 0.0566037735849057 1.46736820006823 0.33556717300696 0.730138823379703 GO:0140296 general transcription initiation factor binding 3/719 53/18639 0.0566037735849057 1.46736820006823 0.33556717300696 0.730138823379703 GO:0098631 cell adhesion mediator activity 4/719 76/18639 0.0526315789473684 1.3643949930459 0.337087134671748 0.730138823379703 GO:0005164 tumor necrosis factor receptor binding 2/719 31/18639 0.0645161290322581 1.672484185024 0.337278760456004 0.730138823379703 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/719 31/18639 0.0645161290322581 1.672484185024 0.337278760456004 0.730138823379703 GO:0017147 Wnt-protein binding 2/719 31/18639 0.0645161290322581 1.672484185024 0.337278760456004 0.730138823379703 GO:0005267 potassium channel activity 6/719 124/18639 0.0483870967741935 1.254363138768 0.345149299046759 0.730138823379703 GO:0000099 sulfur amino acid transmembrane transporter activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0004016 adenylate cyclase activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0005225 volume-sensitive anion channel activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0005536 D-glucose binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0008271 secondary active sulfate transmembrane transporter activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0008432 JUN kinase binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0008503 benzodiazepine receptor activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0008526 phosphatidylinositol transfer activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0010854 adenylate cyclase regulator activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0015205 nucleobase transmembrane transporter activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0019206 nucleoside kinase activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0034056 estrogen response element binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0034713 type I transforming growth factor beta receptor binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0048407 platelet-derived growth factor binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0050786 RAGE receptor binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0050998 nitric-oxide synthase binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0097493 structural molecule activity conferring elasticity 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:1900750 oligopeptide binding 1/719 11/18639 0.0909090909090909 2.35668226071564 0.351338787980587 0.730138823379703 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/719 32/18639 0.0625 1.620219054242 0.351464340446751 0.730138823379703 GO:0042910 xenobiotic transmembrane transporter activity 2/719 32/18639 0.0625 1.620219054242 0.351464340446751 0.730138823379703 GO:0047498 calcium-dependent phospholipase A2 activity 2/719 32/18639 0.0625 1.620219054242 0.351464340446751 0.730138823379703 GO:0098632 cell-cell adhesion mediator activity 3/719 55/18639 0.0545454545454545 1.41400935642938 0.356857340133149 0.738981537748734 GO:0004721 phosphoprotein phosphatase activity 8/719 175/18639 0.0457142857142857 1.18507450824558 0.363223928110791 0.738981537748734 GO:0019956 chemokine binding 2/719 33/18639 0.0606060606060606 1.57112150714376 0.365543261201693 0.738981537748734 GO:0140416 transcription regulator inhibitor activity 2/719 33/18639 0.0606060606060606 1.57112150714376 0.365543261201693 0.738981537748734 GO:0005253 monoatomic anion channel activity 5/719 103/18639 0.0485436893203883 1.25842256640156 0.365767052648782 0.738981537748734 GO:0046906 tetrapyrrole binding 7/719 152/18639 0.0460526315789474 1.19384561891516 0.371193681071076 0.738981537748734 GO:0048306 calcium-dependent protein binding 4/719 80/18639 0.05 1.2961752433936 0.372405653374767 0.738981537748734 GO:0046873 metal ion transmembrane transporter activity 19/719 450/18639 0.0422222222222222 1.09454798331015 0.375986333178197 0.738981537748734 GO:0000340 RNA 7-methylguanosine cap binding 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0004859 phospholipase inhibitor activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0005049 nuclear export signal receptor activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0005078 MAP-kinase scaffold activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0005095 GTPase inhibitor activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0005247 voltage-gated chloride channel activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0005527 macrolide binding 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0008179 adenylate cyclase binding 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0008504 monoamine transmembrane transporter activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0015132 prostaglandin transmembrane transporter activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0016840 carbon-nitrogen lyase activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0017166 vinculin binding 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0035197 siRNA binding 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0035251 UDP-glucosyltransferase activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0035497 cAMP response element binding 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0045295 gamma-catenin binding 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0097677 STAT family protein binding 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/719 12/18639 0.0833333333333333 2.16029207232267 0.376375690033516 0.738981537748734 GO:0030332 cyclin binding 2/719 34/18639 0.0588235294117647 1.5249120510513 0.379502649036447 0.743609653081558 GO:0016298 lipase activity 6/719 130/18639 0.0461538461538462 1.19646945544025 0.386641420400119 0.746695810828359 GO:0017116 single-stranded DNA helicase activity 3/719 58/18639 0.0517241379310345 1.34087094144166 0.38859647481898 0.746695810828359 GO:0000149 SNARE binding 5/719 106/18639 0.0471698113207547 1.22280683339019 0.3888843044638 0.746695810828359 GO:0016229 steroid dehydrogenase activity 2/719 35/18639 0.0571428571428571 1.48134313530697 0.393330779314223 0.746695810828359 GO:0005254 chloride channel activity 4/719 83/18639 0.0481927710843374 1.24932553580106 0.398812124904818 0.746695810828359 GO:0030165 PDZ domain binding 4/719 83/18639 0.0481927710843374 1.24932553580106 0.398812124904818 0.746695810828359 GO:0015459 potassium channel regulator activity 3/719 59/18639 0.0508474576271186 1.31814431531553 0.399096433336081 0.746695810828359 GO:0045309 protein phosphorylated amino acid binding 3/719 59/18639 0.0508474576271186 1.31814431531553 0.399096433336081 0.746695810828359 GO:0004535 poly(A)-specific ribonuclease activity 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0031994 insulin-like growth factor I binding 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0032396 inhibitory MHC class I receptor activity 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0039706 co-receptor binding 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0043560 insulin receptor substrate binding 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0046974 histone H3K9 methyltransferase activity 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0046975 histone H3K36 methyltransferase activity 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0071714 icosanoid transmembrane transporter activity 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0089720 caspase binding 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/719 13/18639 0.0769230769230769 1.99411575906708 0.400447514743126 0.746695810828359 GO:0005179 hormone activity 6/719 132/18639 0.0454545454545455 1.17834113035782 0.400492131462694 0.746695810828359 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 6/719 132/18639 0.0454545454545455 1.17834113035782 0.400492131462694 0.746695810828359 GO:0004843 cysteine-type deubiquitinase activity 5/719 108/18639 0.0462962962962963 1.20016226240148 0.404269103630509 0.746695810828359 GO:0004033 aldo-keto reductase (NADPH) activity 2/719 36/18639 0.0555555555555556 1.44019471488178 0.407017007164891 0.746695810828359 GO:0005484 SNAP receptor activity 2/719 36/18639 0.0555555555555556 1.44019471488178 0.407017007164891 0.746695810828359 GO:0016409 palmitoyltransferase activity 2/719 36/18639 0.0555555555555556 1.44019471488178 0.407017007164891 0.746695810828359 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/719 36/18639 0.0555555555555556 1.44019471488178 0.407017007164891 0.746695810828359 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/719 36/18639 0.0555555555555556 1.44019471488178 0.407017007164891 0.746695810828359 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/719 36/18639 0.0555555555555556 1.44019471488178 0.407017007164891 0.746695810828359 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/719 60/18639 0.05 1.2961752433936 0.40954598697612 0.746695810828359 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/719 60/18639 0.05 1.2961752433936 0.40954598697612 0.746695810828359 GO:0004518 nuclease activity 9/719 209/18639 0.0430622009569378 1.11632317612846 0.416303783893896 0.746695810828359 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/719 61/18639 0.0491803278688525 1.27492646891174 0.419939277324624 0.746695810828359 GO:0005313 L-glutamate transmembrane transporter activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0005347 ATP transmembrane transporter activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0008174 mRNA methyltransferase activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0008474 palmitoyl-(protein) hydrolase activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0008494 translation activator activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0008559 ABC-type xenobiotic transporter activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0015386 potassium:proton antiporter activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0016530 metallochaperone activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0019992 diacylglycerol binding 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0031404 chloride ion binding 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0032454 histone H3K9 demethylase activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0034236 protein kinase A catalytic subunit binding 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0042813 Wnt receptor activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0043176 amine binding 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0044548 S100 protein binding 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0046030 inositol trisphosphate phosphatase activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0061783 peptidoglycan muralytic activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0071933 Arp2/3 complex binding 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0098599 palmitoyl hydrolase activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:1901474 azole transmembrane transporter activity 1/719 14/18639 0.0714285714285714 1.85167891913372 0.423591412353976 0.746695810828359 GO:0016779 nucleotidyltransferase activity 6/719 136/18639 0.0441176470588235 1.14368403828847 0.428121457140127 0.753306607645469 GO:0000146 microfilament motor activity 2/719 38/18639 0.0526315789473684 1.3643949930459 0.433926184438647 0.757848029053833 GO:0043531 ADP binding 2/719 38/18639 0.0526315789473684 1.3643949930459 0.433926184438647 0.757848029053833 GO:0005200 structural constituent of cytoskeleton 5/719 112/18639 0.0446428571428571 1.15729932445857 0.43487451558486 0.757848029053833 GO:1901682 sulfur compound transmembrane transporter activity 3/719 63/18639 0.0476190476190476 1.23445261275581 0.440535122755992 0.757848029053833 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4/719 88/18639 0.0454545454545455 1.17834113035782 0.442339091422159 0.757848029053833 GO:0004089 carbonate dehydratase activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0015116 sulfate transmembrane transporter activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0017081 chloride channel regulator activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0031386 protein tag activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0033130 acetylcholine receptor binding 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0061578 K63-linked deubiquitinase activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0120283 protein serine/threonine kinase binding 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0141047 molecular tag activity 1/719 15/18639 0.0666666666666667 1.72823365785814 0.445843104945519 0.757848029053833 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/719 39/18639 0.0512820512820513 1.32941050604472 0.447132669104317 0.757848029053833 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/719 39/18639 0.0512820512820513 1.32941050604472 0.447132669104317 0.757848029053833 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/719 39/18639 0.0512820512820513 1.32941050604472 0.447132669104317 0.757848029053833 GO:0015081 sodium ion transmembrane transporter activity 7/719 164/18639 0.0426829268292683 1.10649106143356 0.447177408447914 0.757848029053833 GO:0016755 aminoacyltransferase activity 20/719 496/18639 0.0403225806451613 1.04530261564 0.451873277050021 0.763185539399189 GO:0015103 inorganic anion transmembrane transporter activity 7/719 165/18639 0.0424242424242424 1.09978505500063 0.453462649808089 0.763185539399189 GO:0022836 gated channel activity 13/719 318/18639 0.0408805031446541 1.0597659222715 0.455342033346231 0.763185539399189 GO:0035401 histone H3Y41 kinase activity 5/719 115/18639 0.0434782608695652 1.12710890729878 0.45760347306722 0.763185539399189 GO:0101005 deubiquitinase activity 5/719 115/18639 0.0434782608695652 1.12710890729878 0.45760347306722 0.763185539399189 GO:0140801 histone H2AXY142 kinase activity 5/719 115/18639 0.0434782608695652 1.12710890729878 0.45760347306722 0.763185539399189 GO:0015144 carbohydrate transmembrane transporter activity 2/719 40/18639 0.05 1.2961752433936 0.460164207086448 0.763185539399189 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/719 40/18639 0.05 1.2961752433936 0.460164207086448 0.763185539399189 GO:0030331 nuclear estrogen receptor binding 2/719 40/18639 0.05 1.2961752433936 0.460164207086448 0.763185539399189 GO:0061791 GTPase motor activity 2/719 40/18639 0.05 1.2961752433936 0.460164207086448 0.763185539399189 GO:1990606 membrane scission GTPase motor activity 2/719 40/18639 0.05 1.2961752433936 0.460164207086448 0.763185539399189 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0005149 interleukin-1 receptor binding 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0008142 oxysterol binding 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0008296 3'-5'-DNA exonuclease activity 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0015385 sodium:proton antiporter activity 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0015562 efflux transmembrane transporter activity 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0055102 lipase inhibitor activity 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0070411 I-SMAD binding 1/719 16/18639 0.0625 1.620219054242 0.46723694126125 0.763185539399189 GO:0004842 ubiquitin-protein transferase activity 18/719 449/18639 0.0400890868596882 1.03924963835567 0.46770790820323 0.763185539399189 GO:0020037 heme binding 6/719 142/18639 0.0422535211267606 1.09535936061431 0.46914975448446 0.764247323494079 GO:0001727 lipid kinase activity 2/719 41/18639 0.0487804878048781 1.26456121306693 0.473014633960596 0.766664658399222 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/719 41/18639 0.0487804878048781 1.26456121306693 0.473014633960596 0.766664658399222 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/719 41/18639 0.0487804878048781 1.26456121306693 0.473014633960596 0.766664658399222 GO:0019001 guanyl nucleotide binding 16/719 400/18639 0.04 1.03694019471488 0.477166546492321 0.770807498179903 GO:0032561 guanyl ribonucleotide binding 16/719 400/18639 0.04 1.03694019471488 0.477166546492321 0.770807498179903 GO:0019787 ubiquitin-like protein transferase activity 19/719 479/18639 0.0396659707724426 1.02828098640829 0.483760222999471 0.771228391415558 GO:0016859 cis-trans isomerase activity 2/719 42/18639 0.0476190476190476 1.23445261275581 0.485678519594001 0.771228391415558 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0005092 GDP-dissociation inhibitor activity 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0008484 sulfuric ester hydrolase activity 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0016018 cyclosporin A binding 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0032183 SUMO binding 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0045125 bioactive lipid receptor activity 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0048038 quinone binding 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0051787 misfolded protein binding 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0070402 NADPH binding 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0070492 oligosaccharide binding 1/719 17/18639 0.0588235294117647 1.5249120510513 0.487805949435721 0.771228391415558 GO:0005548 phospholipid transporter activity 3/719 68/18639 0.0441176470588235 1.14368403828847 0.49068610590391 0.773250861832263 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/719 68/18639 0.0441176470588235 1.14368403828847 0.49068610590391 0.773250861832263 GO:0005525 GTP binding 15/719 378/18639 0.0396825396825397 1.02871051062984 0.492729419719922 0.775206220601702 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/719 43/18639 0.0465116279069767 1.20574441245916 0.498151120807233 0.777718885083714 GO:0141003 histone H2AX kinase activity 14/719 354/18639 0.0395480225988701 1.02522335635652 0.500690121559158 0.777718885083714 GO:0015108 chloride transmembrane transporter activity 5/719 121/18639 0.0413223140495868 1.0712192094162 0.502209841831868 0.777718885083714 GO:0015085 calcium ion transmembrane transporter activity 6/719 147/18639 0.0408163265306122 1.05810223950498 0.502712788922596 0.777718885083714 GO:0003746 translation elongation factor activity 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0004970 glutamate-gated receptor activity 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0008308 voltage-gated monoatomic anion channel activity 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0015280 ligand-gated sodium channel activity 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0017075 syntaxin-1 binding 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0022851 GABA-gated chloride ion channel activity 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0034185 apolipoprotein binding 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0050811 GABA receptor binding 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0098641 cadherin binding involved in cell-cell adhesion 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:1901611 phosphatidylglycerol binding 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:1990381 ubiquitin-specific protease binding 1/719 18/18639 0.0555555555555556 1.44019471488178 0.507581887699909 0.777718885083714 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/719 70/18639 0.0428571428571429 1.11100735148023 0.510123612794885 0.777718885083714 GO:0016782 transferase activity, transferring sulphur-containing groups 3/719 70/18639 0.0428571428571429 1.11100735148023 0.510123612794885 0.777718885083714 GO:0003954 NADH dehydrogenase activity 2/719 44/18639 0.0454545454545455 1.17834113035782 0.510428336587034 0.777718885083714 GO:0016790 thiolester hydrolase activity 2/719 44/18639 0.0454545454545455 1.17834113035782 0.510428336587034 0.777718885083714 GO:0043014 alpha-tubulin binding 2/719 44/18639 0.0454545454545455 1.17834113035782 0.510428336587034 0.777718885083714 GO:0140996 histone H3 kinase activity 14/719 357/18639 0.0392156862745098 1.0166080340342 0.513537906338194 0.78016645084621 GO:0003924 GTPase activity 13/719 331/18639 0.0392749244712991 1.01814369571703 0.513649961426697 0.78016645084621 GO:0008509 monoatomic anion transmembrane transporter activity 6/719 149/18639 0.0402684563758389 1.04389952488075 0.51592951428188 0.780201001802935 GO:0051539 4 iron, 4 sulfur cluster binding 2/719 45/18639 0.0444444444444444 1.15215577190542 0.522506665724394 0.780201001802935 GO:0140303 intramembrane lipid transporter activity 2/719 45/18639 0.0444444444444444 1.15215577190542 0.522506665724394 0.780201001802935 GO:0019887 protein kinase regulator activity 10/719 255/18639 0.0392156862745098 1.0166080340342 0.524278460072158 0.780201001802935 GO:0035173 histone kinase activity 14/719 360/18639 0.0388888888888889 1.00813630041725 0.526299986019416 0.780201001802935 GO:0004890 GABA-A receptor activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0005229 intracellularly calcium-gated chloride channel activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0005520 insulin-like growth factor binding 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0022821 solute:potassium antiporter activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0042800 histone H3K4 methyltransferase activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0043395 heparan sulfate proteoglycan binding 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0046527 glucosyltransferase activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0070003 threonine-type peptidase activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0140036 ubiquitin-modified protein reader activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0141147 intracellularly calcium-gated channel activity 1/719 19/18639 0.0526315789473684 1.3643949930459 0.526595293142354 0.780201001802935 GO:0042379 chemokine receptor binding 3/719 72/18639 0.0416666666666667 1.08014603616134 0.529163649685083 0.782805644097689 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/719 46/18639 0.0434782608695652 1.12710890729878 0.534383166757824 0.784391685457418 GO:0030276 clathrin binding 2/719 46/18639 0.0434782608695652 1.12710890729878 0.534383166757824 0.784391685457418 GO:0030291 protein serine/threonine kinase inhibitor activity 2/719 46/18639 0.0434782608695652 1.12710890729878 0.534383166757824 0.784391685457418 GO:0004521 RNA endonuclease activity 3/719 73/18639 0.0410958904109589 1.06534951511803 0.53852745312884 0.784391685457418 GO:0043539 protein serine/threonine kinase activator activity 3/719 73/18639 0.0410958904109589 1.06534951511803 0.53852745312884 0.784391685457418 GO:0003779 actin binding 17/719 443/18639 0.0383747178329571 0.99480718454588 0.5440767430422 0.784391685457418 GO:0000339 RNA cap binding 1/719 20/18639 0.05 1.2961752433936 0.544875528600498 0.784391685457418 GO:0010851 cyclase regulator activity 1/719 20/18639 0.05 1.2961752433936 0.544875528600498 0.784391685457418 GO:0016004 phospholipase activator activity 1/719 20/18639 0.05 1.2961752433936 0.544875528600498 0.784391685457418 GO:0016505 peptidase activator activity involved in apoptotic process 1/719 20/18639 0.05 1.2961752433936 0.544875528600498 0.784391685457418 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/719 20/18639 0.05 1.2961752433936 0.544875528600498 0.784391685457418 GO:0042288 MHC class I protein binding 1/719 20/18639 0.05 1.2961752433936 0.544875528600498 0.784391685457418 GO:0043024 ribosomal small subunit binding 1/719 20/18639 0.05 1.2961752433936 0.544875528600498 0.784391685457418 GO:0052745 inositol phosphate phosphatase activity 1/719 20/18639 0.05 1.2961752433936 0.544875528600498 0.784391685457418 GO:0019783 ubiquitin-like protein peptidase activity 5/719 127/18639 0.0393700787401575 1.02061042786898 0.545320373722451 0.784391685457418 GO:0099095 ligand-gated monoatomic anion channel activity 2/719 47/18639 0.0425531914893617 1.10312786671796 0.546055420107395 0.784391685457418 GO:0003678 DNA helicase activity 3/719 74/18639 0.0405405405405405 1.05095290004887 0.547783737202094 0.784391685457418 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 5/719 128/18639 0.0390625 1.01263690890125 0.55233384392917 0.784391685457418 GO:0005261 monoatomic cation channel activity 13/719 341/18639 0.0381231671554252 0.988286109332365 0.557345081212218 0.784391685457418 GO:0003730 mRNA 3'-UTR binding 10/719 262/18639 0.0381679389312977 0.989446750682139 0.558997183540023 0.784391685457418 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0009975 cyclase activity 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0015125 bile acid transmembrane transporter activity 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0036122 BMP binding 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0051010 microtubule plus-end binding 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0051428 peptide hormone receptor binding 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0061891 calcium ion sensor activity 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0070182 DNA polymerase binding 1/719 21/18639 0.0476190476190476 1.23445261275581 0.562450827753849 0.784391685457418 GO:0005216 monoatomic ion channel activity 17/719 448/18639 0.0379464285714286 0.983704425789787 0.562986044786253 0.784391685457418 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5/719 130/18639 0.0384615384615385 0.99705787953354 0.566200422912694 0.784391685457418 GO:0008237 metallopeptidase activity 7/719 184/18639 0.0380434782608696 0.986220293886437 0.56872470430233 0.784391685457418 GO:0001222 transcription corepressor binding 2/719 49/18639 0.0408163265306122 1.05810223950498 0.568779902115493 0.784391685457418 GO:0016763 pentosyltransferase activity 2/719 49/18639 0.0408163265306122 1.05810223950498 0.568779902115493 0.784391685457418 GO:0005262 calcium channel activity 5/719 131/18639 0.0381679389312977 0.989446750682139 0.573050913600003 0.784391685457418 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/719 22/18639 0.0454545454545455 1.17834113035782 0.579348338487816 0.784391685457418 GO:0061133 endopeptidase activator activity 1/719 22/18639 0.0454545454545455 1.17834113035782 0.579348338487816 0.784391685457418 GO:0140035 ubiquitin-like protein reader activity 1/719 22/18639 0.0454545454545455 1.17834113035782 0.579348338487816 0.784391685457418 GO:0140784 metal ion sensor activity 1/719 22/18639 0.0454545454545455 1.17834113035782 0.579348338487816 0.784391685457418 GO:0015605 organophosphate ester transmembrane transporter activity 2/719 50/18639 0.04 1.03694019471488 0.579829588754026 0.784391685457418 GO:0048020 CCR chemokine receptor binding 2/719 50/18639 0.04 1.03694019471488 0.579829588754026 0.784391685457418 GO:0015276 ligand-gated monoatomic ion channel activity 7/719 186/18639 0.0376344086021505 0.975615774597335 0.580223804448319 0.784391685457418 GO:0019199 transmembrane receptor protein kinase activity 3/719 78/18639 0.0384615384615385 0.99705787953354 0.583691348673643 0.784391685457418 GO:0008013 beta-catenin binding 4/719 106/18639 0.0377358490566038 0.978245466712153 0.588392083835109 0.784391685457418 GO:0016597 amino acid binding 2/719 51/18639 0.0392156862745098 1.0166080340342 0.590669881598043 0.784391685457418 GO:0022834 ligand-gated channel activity 7/719 188/18639 0.0372340425531915 0.965236883378214 0.591573067090622 0.784391685457418 GO:0000295 adenine nucleotide transmembrane transporter activity 1/719 23/18639 0.0434782608695652 1.12710890729878 0.595594164594452 0.784391685457418 GO:0003887 DNA-directed DNA polymerase activity 1/719 23/18639 0.0434782608695652 1.12710890729878 0.595594164594452 0.784391685457418 GO:0005283 amino acid:sodium symporter activity 1/719 23/18639 0.0434782608695652 1.12710890729878 0.595594164594452 0.784391685457418 GO:0016493 C-C chemokine receptor activity 1/719 23/18639 0.0434782608695652 1.12710890729878 0.595594164594452 0.784391685457418 GO:0016917 GABA receptor activity 1/719 23/18639 0.0434782608695652 1.12710890729878 0.595594164594452 0.784391685457418 GO:0031681 G-protein beta-subunit binding 1/719 23/18639 0.0434782608695652 1.12710890729878 0.595594164594452 0.784391685457418 GO:0043274 phospholipase binding 1/719 23/18639 0.0434782608695652 1.12710890729878 0.595594164594452 0.784391685457418 GO:0070577 lysine-acetylated histone binding 1/719 23/18639 0.0434782608695652 1.12710890729878 0.595594164594452 0.784391685457418 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 9/719 243/18639 0.037037037037037 0.960129809921187 0.596998612707813 0.784391685457418 GO:0015297 antiporter activity 5/719 135/18639 0.037037037037037 0.960129809921187 0.599873304591018 0.784391685457418 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/719 52/18639 0.0384615384615385 0.99705787953354 0.601300471811284 0.784391685457418 GO:0004676 3-phosphoinositide-dependent protein kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0004711 ribosomal protein S6 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0035175 histone H3S10 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0035979 histone H2AXS139 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0044022 histone H3S28 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0044023 histone H4S1 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0044024 histone H2AS1 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0044025 histone H2BS14 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0072354 histone H3T3 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0072371 histone H2AS121 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0072518 Rho-dependent protein serine/threonine kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0140823 histone H2BS36 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0140855 histone H3S57 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0140995 histone H2A kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0140997 histone H4 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0140998 histone H2B kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:1990244 histone H2AT120 kinase activity 9/719 245/18639 0.036734693877551 0.952292015554483 0.606839823817737 0.784391685457418 GO:0015101 organic cation transmembrane transporter activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:0033192 calmodulin-dependent protein phosphatase activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:0140791 histone H2AXS140 phosphatase activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/719 81/18639 0.037037037037037 0.960129809921187 0.609401481178527 0.784391685457418 GO:0015149 hexose transmembrane transporter activity 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0019957 C-C chemokine binding 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0035035 histone acetyltransferase binding 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0048027 mRNA 5'-UTR binding 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0050431 transforming growth factor beta binding 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0055056 D-glucose transmembrane transporter activity 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0060229 lipase activator activity 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0070300 phosphatidic acid binding 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0140033 acetylation-dependent protein binding 1/719 24/18639 0.0416666666666667 1.08014603616134 0.611213405873813 0.784391685457418 GO:0004677 DNA-dependent protein kinase activity 9/719 246/18639 0.0365853658536585 0.948420909800197 0.611715447654316 0.784391685457418 GO:0140857 histone H3T45 kinase activity 9/719 246/18639 0.0365853658536585 0.948420909800197 0.611715447654316 0.784391685457418 GO:0017046 peptide hormone binding 2/719 53/18639 0.0377358490566038 0.978245466712153 0.611721385489884 0.784391685457418 GO:0035402 histone H3T11 kinase activity 9/719 247/18639 0.0364372469635627 0.944581149031775 0.616560424632303 0.784391685457418 GO:0035403 histone H3T6 kinase activity 9/719 247/18639 0.0364372469635627 0.944581149031775 0.616560424632303 0.784391685457418 GO:0042393 histone binding 9/719 247/18639 0.0364372469635627 0.944581149031775 0.616560424632303 0.784391685457418 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/719 82/18639 0.0365853658536585 0.948420909800197 0.617732181831848 0.784391685457418 GO:0033549 MAP kinase phosphatase activity 3/719 82/18639 0.0365853658536585 0.948420909800197 0.617732181831848 0.784391685457418 GO:0004679 AMP-activated protein kinase activity 9/719 248/18639 0.0362903225806452 0.940772354076002 0.621374281776489 0.784391685457418 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/719 54/18639 0.037037037037037 0.960129809921187 0.621932958350468 0.784391685457418 GO:0050661 NADP binding 2/719 54/18639 0.037037037037037 0.960129809921187 0.621932958350468 0.784391685457418 GO:0140463 chromatin-protein adaptor activity 2/719 54/18639 0.037037037037037 0.960129809921187 0.621932958350468 0.784391685457418 GO:0008236 serine-type peptidase activity 7/719 194/18639 0.0360824742268041 0.935384196263424 0.624663337520388 0.784391685457418 GO:0008017 microtubule binding 10/719 276/18639 0.036231884057971 0.939257422748987 0.625104878063464 0.784391685457418 GO:0030295 protein kinase activator activity 5/719 139/18639 0.0359712230215827 0.932500175103311 0.625719741281625 0.784391685457418 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/719 83/18639 0.036144578313253 0.936994151850797 0.625941683966612 0.784391685457418 GO:0005537 D-mannose binding 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0008139 nuclear localization sequence binding 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0008483 transaminase activity 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0015271 outward rectifier potassium channel activity 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0015645 fatty acid ligase activity 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0017056 structural constituent of nuclear pore 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0019707 protein-cysteine S-acyltransferase activity 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0047617 fatty acyl-CoA hydrolase activity 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0120515 fatty acid-CoA ligase activity 1/719 25/18639 0.04 1.03694019471488 0.626230196697167 0.784391685457418 GO:0015631 tubulin binding 14/719 385/18639 0.0363636363636364 0.942672904286256 0.627879118000285 0.784391685457418 GO:0008374 O-acyltransferase activity 2/719 55/18639 0.0363636363636364 0.942672904286256 0.631935811868104 0.784391685457418 GO:0005201 extracellular matrix structural constituent 6/719 168/18639 0.0357142857142857 0.925839459566859 0.63336659597636 0.784391685457418 GO:0004860 protein kinase inhibitor activity 3/719 84/18639 0.0357142857142857 0.925839459566859 0.634029297304541 0.784391685457418 GO:0017018 myosin phosphatase activity 3/719 84/18639 0.0357142857142857 0.925839459566859 0.634029297304541 0.784391685457418 GO:0106310 protein serine kinase activity 13/719 361/18639 0.03601108033241 0.933533416294561 0.639831075741619 0.784391685457418 GO:0005112 Notch binding 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0005160 transforming growth factor beta receptor binding 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0008066 glutamate receptor activity 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0008143 poly(A) binding 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0008157 protein phosphatase 1 binding 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0015145 monosaccharide transmembrane transporter activity 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0016289 acyl-CoA hydrolase activity 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0030507 spectrin binding 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0034237 protein kinase A regulatory subunit binding 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0043548 phosphatidylinositol 3-kinase binding 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0051139 metal cation:proton antiporter activity 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0120014 phospholipid transfer activity 1/719 26/18639 0.0384615384615385 0.99705787953354 0.640667743090997 0.784391685457418 GO:0017171 serine hydrolase activity 7/719 198/18639 0.0353535353535354 0.91648754583386 0.64587523875422 0.78976643118554 GO:0005385 zinc ion transmembrane transporter activity 1/719 27/18639 0.037037037037037 0.960129809921187 0.654548358398447 0.794338836950879 GO:0008266 poly(U) RNA binding 1/719 27/18639 0.037037037037037 0.960129809921187 0.654548358398447 0.794338836950879 GO:0008395 steroid hydroxylase activity 1/719 27/18639 0.037037037037037 0.960129809921187 0.654548358398447 0.794338836950879 GO:0015252 proton channel activity 1/719 27/18639 0.037037037037037 0.960129809921187 0.654548358398447 0.794338836950879 GO:0016405 CoA-ligase activity 1/719 27/18639 0.037037037037037 0.960129809921187 0.654548358398447 0.794338836950879 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/719 27/18639 0.037037037037037 0.960129809921187 0.654548358398447 0.794338836950879 GO:0008081 phosphoric diester hydrolase activity 3/719 87/18639 0.0344827586206897 0.893913960961105 0.657555985648296 0.796801776710961 GO:0003713 transcription coactivator activity 9/719 256/18639 0.03515625 0.911373218011127 0.658713614536684 0.796801776710961 GO:0009055 electron transfer activity 4/719 116/18639 0.0344827586206897 0.893913960961105 0.659133611419933 0.796801776710961 GO:0008408 3'-5' exonuclease activity 2/719 58/18639 0.0344827586206897 0.893913960961105 0.660702094353499 0.796801776710961 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/719 58/18639 0.0344827586206897 0.893913960961105 0.660702094353499 0.796801776710961 GO:0008194 UDP-glycosyltransferase activity 5/719 145/18639 0.0344827586206897 0.893913960961105 0.662548002114199 0.797509417373603 GO:0019208 phosphatase regulator activity 4/719 117/18639 0.0341880341880342 0.88627367069648 0.665736113661903 0.797509417373603 GO:0005242 inward rectifier potassium channel activity 1/719 28/18639 0.0357142857142857 0.925839459566859 0.667893497572717 0.797509417373603 GO:0019789 SUMO transferase activity 1/719 28/18639 0.0357142857142857 0.925839459566859 0.667893497572717 0.797509417373603 GO:0051119 sugar transmembrane transporter activity 1/719 28/18639 0.0357142857142857 0.925839459566859 0.667893497572717 0.797509417373603 GO:0051959 dynein light intermediate chain binding 1/719 28/18639 0.0357142857142857 0.925839459566859 0.667893497572717 0.797509417373603 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/719 28/18639 0.0357142857142857 0.925839459566859 0.667893497572717 0.797509417373603 GO:0141052 histone H3 demethylase activity 1/719 28/18639 0.0357142857142857 0.925839459566859 0.667893497572717 0.797509417373603 GO:0070888 E-box binding 2/719 59/18639 0.0338983050847458 0.878762876877018 0.66988124035411 0.79889540516305 GO:0004252 serine-type endopeptidase activity 6/719 176/18639 0.0340909090909091 0.883755847768365 0.677476353901759 0.805856839815613 GO:0019210 kinase inhibitor activity 3/719 90/18639 0.0333333333333333 0.864116828929068 0.679973695416854 0.805856839815613 GO:0019209 kinase activator activity 5/719 148/18639 0.0337837837837838 0.875794083374056 0.680055326533688 0.805856839815613 GO:0004181 metallocarboxypeptidase activity 1/719 29/18639 0.0344827586206897 0.893913960961105 0.680723790154804 0.805856839815613 GO:0005416 amino acid:monoatomic cation symporter activity 1/719 29/18639 0.0344827586206897 0.893913960961105 0.680723790154804 0.805856839815613 GO:0016417 S-acyltransferase activity 1/719 29/18639 0.0344827586206897 0.893913960961105 0.680723790154804 0.805856839815613 GO:0016836 hydro-lyase activity 2/719 61/18639 0.0327868852459016 0.849950979274493 0.687635234691789 0.811509167925434 GO:0004540 RNA nuclease activity 4/719 121/18639 0.0330578512396694 0.85697536753296 0.691265350329128 0.811509167925434 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/719 30/18639 0.0333333333333333 0.864116828929068 0.693059071986007 0.811509167925434 GO:0008187 poly-pyrimidine tract binding 1/719 30/18639 0.0333333333333333 0.864116828929068 0.693059071986007 0.811509167925434 GO:0016769 transferase activity, transferring nitrogenous groups 1/719 30/18639 0.0333333333333333 0.864116828929068 0.693059071986007 0.811509167925434 GO:0032452 histone demethylase activity 1/719 30/18639 0.0333333333333333 0.864116828929068 0.693059071986007 0.811509167925434 GO:0048019 receptor antagonist activity 1/719 30/18639 0.0333333333333333 0.864116828929068 0.693059071986007 0.811509167925434 GO:0051721 protein phosphatase 2A binding 1/719 30/18639 0.0333333333333333 0.864116828929068 0.693059071986007 0.811509167925434 GO:0070566 adenylyltransferase activity 1/719 30/18639 0.0333333333333333 0.864116828929068 0.693059071986007 0.811509167925434 GO:0051219 phosphoprotein binding 3/719 93/18639 0.032258064516129 0.836242092512001 0.701284073107556 0.816488236894184 GO:0004674 protein serine/threonine kinase activity 15/719 433/18639 0.0346420323325635 0.898042893806191 0.701961161160277 0.816488236894184 GO:0022824 transmitter-gated monoatomic ion channel activity 2/719 63/18639 0.0317460317460317 0.822968408503874 0.704596966704808 0.816488236894184 GO:0022835 transmitter-gated channel activity 2/719 63/18639 0.0317460317460317 0.822968408503874 0.704596966704808 0.816488236894184 GO:0005184 neuropeptide hormone activity 1/719 31/18639 0.032258064516129 0.836242092512001 0.704918415703674 0.816488236894184 GO:0008327 methyl-CpG binding 1/719 31/18639 0.032258064516129 0.836242092512001 0.704918415703674 0.816488236894184 GO:0016411 acylglycerol O-acyltransferase activity 1/719 31/18639 0.032258064516129 0.836242092512001 0.704918415703674 0.816488236894184 GO:0016878 acid-thiol ligase activity 1/719 31/18639 0.032258064516129 0.836242092512001 0.704918415703674 0.816488236894184 GO:0140457 protein demethylase activity 1/719 31/18639 0.032258064516129 0.836242092512001 0.704918415703674 0.816488236894184 GO:0016757 glycosyltransferase activity 9/719 267/18639 0.0337078651685393 0.873826006782204 0.706416691584337 0.81724374140176 GO:0005506 iron ion binding 5/719 154/18639 0.0324675324675325 0.841672235969871 0.713210932107995 0.820836624702882 GO:0008276 protein methyltransferase activity 3/719 95/18639 0.0315789473684211 0.818636995827538 0.714880343825725 0.820836624702882 GO:0031369 translation initiation factor binding 1/719 32/18639 0.03125 0.810109527121001 0.716320160066801 0.820836624702882 GO:0043425 bHLH transcription factor binding 1/719 32/18639 0.03125 0.810109527121001 0.716320160066801 0.820836624702882 GO:0051059 NF-kappaB binding 1/719 32/18639 0.03125 0.810109527121001 0.716320160066801 0.820836624702882 GO:0070717 poly-purine tract binding 1/719 32/18639 0.03125 0.810109527121001 0.716320160066801 0.820836624702882 GO:0140142 nucleocytoplasmic carrier activity 1/719 32/18639 0.03125 0.810109527121001 0.716320160066801 0.820836624702882 GO:0160041 neuropeptide activity 1/719 32/18639 0.03125 0.810109527121001 0.716320160066801 0.820836624702882 GO:0160215 deacylase activity 2/719 65/18639 0.0307692307692308 0.797646303626832 0.720784507512767 0.824973737271721 GO:0004519 endonuclease activity 4/719 127/18639 0.031496062992126 0.816488342295183 0.7269054932564 0.830442496760071 GO:0030296 protein tyrosine kinase activator activity 1/719 33/18639 0.0303030303030303 0.78556075357188 0.727281938156335 0.830442496760071 GO:0031406 carboxylic acid binding 6/719 187/18639 0.0320855614973262 0.831770209664344 0.732278669463355 0.835160796578041 GO:0016500 protein-hormone receptor activity 2/719 67/18639 0.0298507462686567 0.773835966205136 0.736217730540079 0.837526205100504 GO:0042054 histone methyltransferase activity 2/719 67/18639 0.0298507462686567 0.773835966205136 0.736217730540079 0.837526205100504 GO:0015035 protein-disulfide reductase activity 1/719 34/18639 0.0294117647058824 0.762456025525648 0.737820704493302 0.837526205100504 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/719 34/18639 0.0294117647058824 0.762456025525648 0.737820704493302 0.837526205100504 GO:0043177 organic acid binding 6/719 189/18639 0.0317460317460317 0.822968408503874 0.741498552630028 0.840713147700243 GO:0000175 3'-5'-RNA exonuclease activity 1/719 35/18639 0.0285714285714286 0.740671567653487 0.747952761116216 0.843083275657251 GO:0005154 epidermal growth factor receptor binding 1/719 35/18639 0.0285714285714286 0.740671567653487 0.747952761116216 0.843083275657251 GO:0005343 organic acid:sodium symporter activity 1/719 35/18639 0.0285714285714286 0.740671567653487 0.747952761116216 0.843083275657251 GO:0034061 DNA polymerase activity 1/719 35/18639 0.0285714285714286 0.740671567653487 0.747952761116216 0.843083275657251 GO:0043015 gamma-tubulin binding 1/719 35/18639 0.0285714285714286 0.740671567653487 0.747952761116216 0.843083275657251 GO:0002039 p53 binding 2/719 69/18639 0.0289855072463768 0.75140593819919 0.750917936152873 0.844454861843627 GO:0016279 protein-lysine N-methyltransferase activity 2/719 69/18639 0.0289855072463768 0.75140593819919 0.750917936152873 0.844454861843627 GO:0004190 aspartic-type endopeptidase activity 1/719 36/18639 0.0277777777777778 0.72009735744089 0.757693782657682 0.849452573064309 GO:0045505 dynein intermediate chain binding 1/719 36/18639 0.0277777777777778 0.72009735744089 0.757693782657682 0.849452573064309 GO:0016278 lysine N-methyltransferase activity 2/719 70/18639 0.0285714285714286 0.740671567653487 0.75800012213399 0.849452573064309 GO:0004722 protein serine/threonine phosphatase activity 3/719 103/18639 0.029126213592233 0.755053539840933 0.764496330438629 0.854646874144103 GO:0140299 molecular sensor activity 2/719 71/18639 0.028169014084507 0.730239573742875 0.764907522647581 0.854646874144103 GO:0019213 deacetylase activity 1/719 37/18639 0.027027027027027 0.700635266699244 0.767058840458527 0.854646874144103 GO:0022829 wide pore channel activity 1/719 37/18639 0.027027027027027 0.700635266699244 0.767058840458527 0.854646874144103 GO:0070001 aspartic-type peptidase activity 1/719 37/18639 0.027027027027027 0.700635266699244 0.767058840458527 0.854646874144103 GO:0099094 ligand-gated monoatomic cation channel activity 4/719 136/18639 0.0294117647058824 0.762456025525648 0.774467915182498 0.861696900322581 GO:0005109 frizzled binding 1/719 38/18639 0.0263157894736842 0.682197496522949 0.776062425756362 0.861696900322581 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/719 38/18639 0.0263157894736842 0.682197496522949 0.776062425756362 0.861696900322581 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/719 73/18639 0.0273972602739726 0.710233010078686 0.778209698741172 0.86308905738688 GO:0004497 monooxygenase activity 3/719 106/18639 0.0283018867924528 0.733684100034114 0.781201630553013 0.86541373292914 GO:0035064 methylated histone binding 2/719 74/18639 0.027027027027027 0.700635266699244 0.784610419895035 0.867320416403421 GO:0000217 DNA secondary structure binding 1/719 39/18639 0.0256410256410256 0.66470525302236 0.784718471984047 0.867320416403421 GO:0004532 RNA exonuclease activity 1/719 40/18639 0.025 0.648087621696801 0.793040376212191 0.872525060843936 GO:0015036 disulfide oxidoreductase activity 1/719 40/18639 0.025 0.648087621696801 0.793040376212191 0.872525060843936 GO:0032451 demethylase activity 1/719 40/18639 0.025 0.648087621696801 0.793040376212191 0.872525060843936 GO:0071855 neuropeptide receptor binding 1/719 40/18639 0.025 0.648087621696801 0.793040376212191 0.872525060843936 GO:0051536 iron-sulfur cluster binding 2/719 76/18639 0.0263157894736842 0.682197496522949 0.796926161564572 0.874807581899291 GO:0140034 methylation-dependent protein binding 2/719 76/18639 0.0263157894736842 0.682197496522949 0.796926161564572 0.874807581899291 GO:0008227 G protein-coupled amine receptor activity 1/719 41/18639 0.024390243902439 0.632280606533465 0.801041019768481 0.877319492571678 GO:0140828 metal cation:monoatomic cation antiporter activity 1/719 41/18639 0.024390243902439 0.632280606533465 0.801041019768481 0.877319492571678 GO:0005125 cytokine activity 7/719 234/18639 0.0299145299145299 0.77548946185942 0.802700372455188 0.877319492571678 GO:0051540 metal cluster binding 2/719 77/18639 0.025974025974026 0.673337788775897 0.802847237508658 0.877319492571678 GO:0004520 DNA endonuclease activity 1/719 42/18639 0.0238095238095238 0.617226306377906 0.808732788065419 0.881756064640175 GO:0051879 Hsp90 protein binding 1/719 42/18639 0.0238095238095238 0.617226306377906 0.808732788065419 0.881756064640175 GO:0015370 solute:sodium symporter activity 2/719 79/18639 0.0253164556962025 0.656291262477773 0.814230978425012 0.884754921438202 GO:0016835 carbon-oxygen lyase activity 2/719 79/18639 0.0253164556962025 0.656291262477773 0.814230978425012 0.884754921438202 GO:0033293 monocarboxylic acid binding 2/719 79/18639 0.0253164556962025 0.656291262477773 0.814230978425012 0.884754921438202 GO:0005245 voltage-gated calcium channel activity 1/719 43/18639 0.0232558139534884 0.602872206229582 0.816127589666804 0.885819383840599 GO:0051015 actin filament binding 6/719 209/18639 0.0287081339712919 0.744215450752308 0.821289877728586 0.890422022318534 GO:0001223 transcription coactivator binding 1/719 44/18639 0.0227272727272727 0.58917056517891 0.823236874622148 0.890533953958561 GO:0030547 signaling receptor inhibitor activity 1/719 44/18639 0.0227272727272727 0.58917056517891 0.823236874622148 0.890533953958561 GO:0045296 cadherin binding 10/719 334/18639 0.029940119760479 0.776152840355451 0.833979644904278 0.901145790802609 GO:0019842 vitamin binding 4/719 150/18639 0.0266666666666667 0.691293463143255 0.835178360175359 0.901432732882008 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/719 46/18639 0.0217391304347826 0.563554453649392 0.836642507326859 0.902005203211769 GO:0016741 transferase activity, transferring one-carbon groups 6/719 215/18639 0.027906976744186 0.723446647475499 0.841018736302686 0.904496981731022 GO:0005504 fatty acid binding 1/719 47/18639 0.0212765957446809 0.55156393335898 0.842959617918586 0.904496981731022 GO:0140938 histone H3 methyltransferase activity 1/719 47/18639 0.0212765957446809 0.55156393335898 0.842959617918586 0.904496981731022 GO:0003774 cytoskeletal motor activity 4/719 153/18639 0.0261437908496732 0.677738689356132 0.846247109931516 0.904496981731022 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1/719 48/18639 0.0208333333333333 0.540073018080668 0.849032769527694 0.904496981731022 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/719 48/18639 0.0208333333333333 0.540073018080668 0.849032769527694 0.904496981731022 GO:0032266 phosphatidylinositol-3-phosphate binding 1/719 48/18639 0.0208333333333333 0.540073018080668 0.849032769527694 0.904496981731022 GO:0005004 GPI-linked ephrin receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0005008 hepatocyte growth factor receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0005009 insulin receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0005011 macrophage colony-stimulating factor receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0005020 stem cell factor receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0008288 boss receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0036332 placental growth factor receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0038062 protein tyrosine kinase collagen receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0060175 brain-derived neurotrophic factor receptor activity 1/719 49/18639 0.0204081632653061 0.529051119752491 0.854871370932115 0.904496981731022 GO:0005006 epidermal growth factor receptor activity 1/719 50/18639 0.02 0.518470097357441 0.860484468527586 0.906464554632114 GO:0005007 fibroblast growth factor receptor activity 1/719 50/18639 0.02 0.518470097357441 0.860484468527586 0.906464554632114 GO:0005017 platelet-derived growth factor receptor activity 1/719 50/18639 0.02 0.518470097357441 0.860484468527586 0.906464554632114 GO:0005019 platelet-derived growth factor beta-receptor activity 1/719 50/18639 0.02 0.518470097357441 0.860484468527586 0.906464554632114 GO:0005010 insulin-like growth factor receptor activity 1/719 51/18639 0.0196078431372549 0.508304017017099 0.865880760266177 0.908187637803612 GO:0005030 neurotrophin receptor activity 1/719 51/18639 0.0196078431372549 0.508304017017099 0.865880760266177 0.908187637803612 GO:0005048 signal sequence binding 1/719 51/18639 0.0196078431372549 0.508304017017099 0.865880760266177 0.908187637803612 GO:0016830 carbon-carbon lyase activity 1/719 51/18639 0.0196078431372549 0.508304017017099 0.865880760266177 0.908187637803612 GO:0030159 signaling receptor complex adaptor activity 1/719 52/18639 0.0192307692307692 0.49852893976677 0.87106860905941 0.90996790298264 GO:0052689 carboxylic ester hydrolase activity 2/719 92/18639 0.0217391304347826 0.563554453649392 0.874880960275725 0.90996790298264 GO:0004864 protein phosphatase inhibitor activity 1/719 53/18639 0.0188679245283019 0.489122733356076 0.876056055666516 0.90996790298264 GO:0005003 ephrin receptor activity 1/719 53/18639 0.0188679245283019 0.489122733356076 0.876056055666516 0.90996790298264 GO:0005005 transmembrane-ephrin receptor activity 1/719 53/18639 0.0188679245283019 0.489122733356076 0.876056055666516 0.90996790298264 GO:0005544 calcium-dependent phospholipid binding 1/719 53/18639 0.0188679245283019 0.489122733356076 0.876056055666516 0.90996790298264 GO:0016860 intramolecular oxidoreductase activity 1/719 53/18639 0.0188679245283019 0.489122733356076 0.876056055666516 0.90996790298264 GO:0038064 collagen receptor activity 1/719 53/18639 0.0188679245283019 0.489122733356076 0.876056055666516 0.90996790298264 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/719 53/18639 0.0188679245283019 0.489122733356076 0.876056055666516 0.90996790298264 GO:0003925 G protein activity 1/719 54/18639 0.0185185185185185 0.480064904960593 0.880850831087574 0.913344466633553 GO:0016758 hexosyltransferase activity 5/719 197/18639 0.0253807106598985 0.65795697634193 0.881197766979784 0.913344466633553 GO:0000287 magnesium ion binding 6/719 230/18639 0.0260869565217391 0.676265344379271 0.882692855962925 0.913913503601485 GO:0019212 phosphatase inhibitor activity 1/719 56/18639 0.0178571428571429 0.462919729783429 0.889891814620352 0.917472560432757 GO:0030170 pyridoxal phosphate binding 1/719 56/18639 0.0178571428571429 0.462919729783429 0.889891814620352 0.917472560432757 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/719 56/18639 0.0178571428571429 0.462919729783429 0.889891814620352 0.917472560432757 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 4/719 167/18639 0.0239520958083832 0.62092227228436 0.889929388328668 0.917472560432757 GO:0030594 neurotransmitter receptor activity 2/719 97/18639 0.0206185567010309 0.534505255007671 0.892907106787941 0.919561050274149 GO:0070279 vitamin B6 binding 1/719 57/18639 0.0175438596491228 0.454798331015299 0.894152040917934 0.919862482989056 GO:0008170 N-methyltransferase activity 2/719 98/18639 0.0204081632653061 0.529051119752491 0.896209955433957 0.920998741435322 GO:0008168 methyltransferase activity 5/719 204/18639 0.0245098039215686 0.635380021271374 0.89850505955892 0.92237607601904 GO:0070063 RNA polymerase binding 1/719 59/18639 0.0169491525423729 0.439381438438509 0.902185005975236 0.925170611223012 GO:0019888 protein phosphatase regulator activity 2/719 107/18639 0.0186915887850467 0.484551492857421 0.921939892912842 0.94431786766514 GO:0019843 rRNA binding 1/719 65/18639 0.0153846153846154 0.398823151813416 0.92281166363964 0.94431786766514 GO:0008173 RNA methyltransferase activity 1/719 67/18639 0.0149253731343284 0.386917983102568 0.928672079014079 0.948732647432043 GO:0004222 metalloendopeptidase activity 2/719 110/18639 0.0181818181818182 0.471336452143128 0.929090149555603 0.948732647432043 GO:0140098 catalytic activity, acting on RNA 10/719 387/18639 0.0258397932816537 0.669858006921758 0.933629159847232 0.950820997010472 GO:0008080 N-acetyltransferase activity 1/719 69/18639 0.0144927536231884 0.375702969099595 0.934088122321882 0.950820997010472 GO:0098960 postsynaptic neurotransmitter receptor activity 1/719 69/18639 0.0144927536231884 0.375702969099595 0.934088122321882 0.950820997010472 GO:0017022 myosin binding 1/719 76/18639 0.0131578947368421 0.341098748261474 0.950008240603675 0.966008379392789 GO:0008528 G protein-coupled peptide receptor activity 2/719 122/18639 0.0163934426229508 0.424975489637247 0.95195212043001 0.966967138102408 GO:0000049 tRNA binding 1/719 80/18639 0.0125 0.324043810848401 0.957315621321175 0.971393792222957 GO:0016874 ligase activity 3/719 167/18639 0.0179640718562874 0.46569170421327 0.95854160950687 0.971617203340647 GO:0001653 peptide receptor activity 2/719 128/18639 0.015625 0.405054763560501 0.960555299074529 0.972637755666661 GO:0043021 ribonucleoprotein complex binding 3/719 177/18639 0.0169491525423729 0.439381438438509 0.969159153458085 0.980322243183781 GO:0016853 isomerase activity 3/719 180/18639 0.0166666666666667 0.432058414464534 0.971806111728898 0.981786663417537 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3/719 181/18639 0.0165745856353591 0.429671351401194 0.972639582702467 0.981786663417537 GO:0051213 dioxygenase activity 1/719 93/18639 0.010752688172043 0.278747364170667 0.974465992290406 0.98257602274771 GO:0016410 N-acyltransferase activity 1/719 94/18639 0.0106382978723404 0.27578196667949 0.975455906640843 0.98257602274771 GO:0016407 acetyltransferase activity 1/719 96/18639 0.0104166666666667 0.270036509040334 0.977322238756253 0.98343050274848 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4/719 229/18639 0.0174672489082969 0.452812312102568 0.978568123570227 0.983659528999832 GO:0043022 ribosome binding 1/719 112/18639 0.00892857142857143 0.231459864891715 0.987958251729583 0.992066186248209 GO:0045182 translation regulator activity 6/719 356/18639 0.0168539325842697 0.436913003391102 0.994440577926611 0.997538523652238 GO:0030371 translation repressor activity 4/719 329/18639 0.0121580547112462 0.315179390490846 0.998926668135005 0.999992638560191 GO:0003735 structural constituent of ribosome 1/719 175/18639 0.00571428571428571 0.148134313530697 0.999009465148596 0.999992638560191 GO:1903231 mRNA base-pairing translational repressor activity 1/719 298/18639 0.00335570469798658 0.0869916270733961 0.999992638560191 0.999992638560191