category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	152/1634	250/9376	3.48874418604651	LIPA/CTSD/NPC2/ACP5/ASAH1/CTSZ/LAPTM5/LGMN/PPT1/ATP6V0D1/CTSS/PSAP/SCARB2/LAMP1/CD68/DNASE2/PLA2G15/ATP6AP1/HEXB/HEXA/FUCA1/GM2A/LAMP2/CTSB/ACP2/SLC15A3/GNS/AP1S2/GUSB/M6PR/BLOC1S2/TCIRG1/ROGDI/FUCA2/ATP6V0B/GLB1/SLC17A5/CTSC/CLN8/ATP6V0E1/GAA/CTSA/GLA/ATP6V1D/ARL8A/CTSH/MCOLN1/NAGA/VAMP8/LITAF/ATP6V0A1/ATP6V1B2/DMXL2/SLC29A3/AP1B1/SNAPIN/VPS13C/NAGLU/IGF2R/CD63/ATP6V1H/SUMF1/IDS/GNPTAB/RRAGD/OSBPL1A/MITF/BLOC1S6/NEU1/MANBA/VPS35/CTBS/SORT1/TPP1/GGA2/ATP6V1A/GGA1/RRAGC/LAMTOR1/SNAP29/VPS29/GNPTG/NAGPA/LAMTOR3/OSTM1/AP2B1/LAMTOR2/GALC/HYAL2/SMPD1/AP3D1/VPS41/AP3B1/CLTC/TFEB/CLN6/AP2A2/AP2S1/GALNS/ATP6V1F/SLC11A2/LAPTM4A/AGA/FIG4/HGSNAT/SLC36A1/AP1M1/RAB7A/ARSB/LAMTOR4/ATP6V0E2/ARSA/TPCN1/SPG11/GPR155/VPS18/NCOA7/ATP6V1G1/VPS16/CTSO/AP5B1/VPS26B/CLN5/VAMP7/OSBP/AP1G1/AP5M1/PLEKHM1/WDR7/DMXL1/VPS33A/TPCN2/CD164/AP5S1/CTSK/CTNS/SGSH/ZFYVE26/VPS13A/TMEM175/TLR7/TLR8/ARSG/GGA3/MTOR/DNASE2B/OSBPL2/OSBPL3/SLC2A6/VPS11/CTSF/MAN2B1	18.3229379721622
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	80/1634	181/9376	2.53616181015303	ITGB2/CTSD/HLA-DMB/LSP1/HLA-DPA1/HLA-DMA/ATP6V0D1/HLA-DQA2/HLA-DRA/CTSS/HLA-DPB1/CD74/LAMP1/ATP6AP1/IL18/ITGAX/LAMP2/TCIRG1/ATP6V0B/CORO1A/ITGAM/IL10RB/RHOA/ATP6V0A1/MAPK1/IFNGR1/ATP6V1H/CALM3/HLA-DQA1/BID/TNFRSF1A/RAB5C/TRADD/FCGR1A/STAT1/C3/HLA-DOA/NFKB1/JAK1/IL10RA/HLA-DQB1/MAPK13/BCL10/SYK/CLEC7A/FCER1G/HLA-DRB1/NFYC/SPHK1/BAX/CALM2/CAMK2D/PLK3/CARD9/HSPA9/EEA1/IFNGR2/PPP3CB/RAB7A/MAPK14/CASP3/IRAK4/EP300/FCGR3A/AKT2/RIPK2/CREB1/TLR1/MRC2/CIITA/CEBPB/CREBBP/CYCS/CASP8/BCL2/VDR/PIK3C3/SRC/CASP10/RFX5	9.58706044534459
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	70/1634	155/9376	2.59138468827733	ITGB2/HLA-B/CYBA/HLA-DMB/MSR1/CD36/HLA-DPA1/HLA-DMA/ATP6V0D1/HLA-DQA2/HLA-DRA/CTSS/HLA-DPB1/HLA-E/HLA-F/HLA-C/LAMP1/ATP6AP1/NCF2/LAMP2/M6PR/TFRC/TCIRG1/ATP6V0B/OLR1/ATP6V0E1/ITGB5/CYBB/CORO1A/ATP6V1D/ITGAM/ATP6V0A1/ATP6V1B2/TUBA1A/ATP6V1H/RILP/HLA-DQA1/ACTB/RAB5C/FCGR1A/VAMP3/ITGAV/ATP6V1A/C3/STX7/HLA-DOA/NCF4/DYNC1H1/CANX/ACTG1/SEC61A1/HLA-DQB1/TAP1/HLA-A/CLEC7A/HLA-DRB1/STX18/ATP6V1F/EEA1/RAB7A/ATP6V0E2/SCARB1/RAC1/FCGR3A/ATP6V1G1/MRC2/THBS3/CALR/ITGB1/PIK3C3	9.17776839747304
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	91/1634	248/9376	2.10550005922533	ANXA2/ARPC1B/ARPC4/PTPRC/RHOG/IL18/AHNAK/STX10/NCKAP1L/LY96/CYFIP1/M6PR/RRAS/KPNA3/ARL8A/PLEKHM2/RHOA/MAPK1/TUBA1A/RILP/PYCARD/TNFRSF1A/ACTB/RAB5C/TRADD/ACTR3/ARPC2/ACTR1A/ACTR10/ACBD3/NFKB1/DYNC1H1/RAB9A/ACTG1/RHOB/MAPK13/VPS41/CASP1/SNX9/KPNA4/IKBKG/FLNA/BAX/BAK1/CYTH4/TAB2/CYTH1/ACTR2/MAP2K3/MYL12A/DYNLT3/SNX18/RAB7A/BIRC2/MAPK14/VPS18/CASP3/IRAK4/FHOD1/RAC1/ARPC3/AKT2/RIPK2/VPS16/ACTR1B/KIF5B/TLR5/MAP3K7/PFN1/EXOC4/ELMO1/PLEKHM1/HSP90B1/CYCS/MLKL/CASP8/ARF1/PIK3CA/IKBKB/VPS33A/BCL2/NLRC4/KPNA1/PIK3CG/PIK3C3/ELMO2/HSP90AA1/TNFRSF10A/ARPC5/VPS11/MAP2K7	8.10553855115657
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	71/1634	174/9376	2.34139478608309	HSPA1A/HSPA1B/DNAJB1/BCAP31/HERPUD1/MAN1A1/BCAP29/DERL1/OS9/DNAJC3/SEC63/SAR1B/DNAJC1/EDEM2/HSPH1/TRAM1/SIL1/SEL1L/STT3B/DERL2/SSR1/DNAJC10/SEC31A/CANX/DNAJB12/DNAJB11/DNAJC5/SEC61A1/HSPA8/STUB1/ERLEC1/AMFR/MAN1B1/NGLY1/RNF5/BAX/BAK1/RPN1/NFE2L2/UBE2G1/ERP29/MAGT1/EDEM3/SEC23A/SEC62/SSR3/EDEM1/PREB/SEC24D/P4HB/MBTPS1/FBXO6/ATF6/UBE4B/HSP90B1/HSPA6/MAP3K5/CALR/BCL2/ERN1/SYVN1/UBXN4/DAD1/SEC24B/DNAJC5B/HSP90AA1/UBQLN2/EIF2AK3/PDIA6/MAP2K7/HSPA5	8.20493612450519
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	51/1634	112/9376	2.61286938275922	HSPA1A/HSPA1B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/GNAI2/LY96/ALOX5/IL10RB/ITGA6/MAPK1/IFNGR1/HLA-DQA1/TNFRSF1A/XIAP/STAT1/HLA-DOA/NFKB1/JAK1/IL10RA/HSPA8/HLA-DQB1/MAPK13/BCL2L1/PDPK1/CD40/HLA-DRB1/IKBKG/GNAI3/TAB2/IFNGR2/MAP2K3/BIRC2/MAPK14/CASP3/IRAK4/PIK3R5/AKT2/PPIF/MAP3K7/CIITA/CYCS/CASP8/HSPA6/ITGB1/IKBKB/BCL2/PIK3CG	7.88849249504125
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	67/1634	169/9376	2.27485460589688	CTSD/LAMP1/LAMP2/CTSB/MRAS/GABARAP/RRAS/ATG7/WIPI2/VAMP8/MAPK1/GABARAPL2/PIK3R1/RRAGD/PRKCD/PRKACB/DAPK1/RRAGC/SNAP29/MTMR14/STX7/EIF2AK4/PRKACA/VPS41/HIF1A/RAB1A/GABARAPL1/ATG5/BCL2L1/PDPK1/PPP2CB/BECN1/WDR41/BIRC6/CFLAR/MAP1LC3B/UVRAG/WDR45/IRS2/ATG4B/YKT6/RAB7A/SUPT20H/VPS18/ITPR1/AKT2/PRKAA1/VPS16/MAP3K7/PLEKHM1/DDIT4/NBR1/PIK3CA/VPS33A/BCL2/ERN1/MTMR3/ATG2A/PIK3C3/ATG16L2/ATG13/MTOR/UBC/ULK2/VPS11/DAPK3/EIF2AK3	7.68298559446433
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	88/1634	250/9376	2.01979926560587	HSPA1A/HSPA1B/HLA-B/HLA-E/ARPC1B/ARPC4/HLA-F/HLA-C/ARRB2/CXCR4/TGFBR1/CHMP1B/TFRC/SMAP1/RAB31/RHOA/WIPF1/ACAP2/SH3KBP1/IGF2R/GIT2/ASAP1/SNX5/RAB5C/EHD4/CAPZA2/ACTR3/ARPC2/ARAP1/PDCD6IP/VPS35/SNX1/RUFY1/SPG21/VPS29/CHMP3/RAB22A/AP2B1/TGFBR2/HSPA8/SMURF2/HLA-A/CLTC/RAB11B/AGAP3/IST1/SMAD2/AP2A2/CBL/VPS36/CAPZA1/AP2S1/CYTH4/RAB4A/CYTH1/RAB11FIP1/ITCH/ACTR2/EEA1/ARRB1/DAB2/RAB7A/ARFGEF1/VPS28/STAMBP/IL2RG/STAM/ARPC3/KIF5B/IQSEC1/STAM2/VPS26B/PSD3/WWP1/HSPA6/ARF1/VPS37B/GIT1/RAB11FIP2/WIPF3/PLD1/GBF1/SRC/PLD2/RUFY2/PSD4/ARPC5/EPS15L1	7.50809134683954
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	55/1634	138/9376	2.28691040036897	CD4/ARPC1B/ARPC4/RHOG/IL18/FN1/SKAP2/RPS6KA1/LIMK1/RHOA/WIPF1/WASF2/MAPK1/PIK3R1/PYCARD/WAS/ROCK1/GIT2/ACTB/RPS6KA3/ACTR3/ARPC2/RAC2/LCP2/NFKB1/ACTG1/VAV1/MAPK13/CASP1/ARHGEF1/IKBKG/TAB2/ACTR2/MAP2K3/MAPK14/ITGA4/IRAK4/RAC1/ARPC3/AKT2/RPS6KA2/GSK3B/MAP3K7/ELMO1/BAIAP2/LAT/PIK3CA/ITGB1/IKBKB/NLRC4/WIPF3/ELMO2/SRC/ARPC5/MAP2K7	6.99655021992189
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	55/1634	142/9376	2.22249038909097	TREM2/ACP5/CYBA/CSF1R/OSCAR/NCF2/TGFBR1/SPI1/LILRB4/SIRPA/IFNAR1/BTK/MAPK1/TYROBP/IFNGR1/PIK3R1/MITF/TNFRSF1A/FCGR1A/LCP2/STAT1/ATP2A2/NCF4/NFKB1/JAK1/LILRB3/TGFBR2/MAPK13/SYK/FOSL2/IKBKG/TAB2/IFNGR2/JUNB/SIRPB1/PPP3CB/BLNK/RELB/CYLD/MAPK14/ITPR1/RAC1/FCGR3A/AKT2/CREB1/PLCG2/MAP3K7/ITPR2/CSF1/LILRA2/PIK3CA/IKBKB/CTSK/TNFRSF11A/MAP2K7	6.74341319488584
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	64/1634	180/9376	2.04020127838977	HLA-B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-E/B2M/CD74/HLA-F/HLA-C/TAPBP/TNFRSF14/PILRA/BST2/IFNAR1/IFNGR1/EIF4EBP1/PIK3R1/HLA-DQA1/BID/TNFRSF1A/TRADD/STAT1/C3/HLA-DOA/NFKB1/JAK1/HLA-DQB1/TAP1/SYK/HLA-A/BCL2L1/HLA-DRB1/IKBKG/BAX/BAK1/TAB2/TAPBPL/CARD9/IFNGR2/IFIH1/TRAF3/ZC3HAV1/BIRC2/DAXX/CASP3/IRAK4/AKT2/MAP3K7/EIF2B5/CYCS/CASP8/CALR/PIK3CA/IKBKB/BCL2/POU2F2/IKBKE/RNASEL/SRC/MTOR/CCL5	6.47350123571462
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	68/1634	196/9376	1.99075762495941	HLA-B/HLA-E/HLA-F/HLA-C/CLEC2B/GNB4/IFNAR1/MAPK1/IFNGR1/CALM3/PIK3R1/BID/TNFRSF1A/TRADD/HCK/STAT1/C3/CDK6/NFKB1/MAPKAPK2/JAK1/GNB2/MAPK13/CD86/HIF1A/SYK/HLA-A/BECN1/IKBKG/BAX/BAK1/PREX1/CALM2/MAP1LC3B/GNB1/RB1/PPP3CB/TRAF3/MAPK14/CASP3/ITPR1/PIK3R5/EP300/RAC1/AKT2/CCND1/CREB1/GSK3B/E2F3/PLCG2/ZFP36/ITPR2/CREBBP/CYCS/CASP8/PIK3CA/IKBKB/MICA/GNGT2/IKBKE/PIK3CG/PIK3C3/SRC/MTOR/MICB/UBC/VEGFA/MAP2K7	6.43960456046225
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	70/1634	205/9376	1.95933964235603	VIM/HLA-B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-E/B2M/HLA-F/HLA-C/TAPBP/IFNAR1/BTK/NFKBIE/PIK3R1/HLA-DQA1/BID/GADD45B/TRADD/ITGAL/STAT1/CDK6/GADD45G/HLA-DOA/NFKB1/CD58/JAK1/HLA-DQB1/MAPK13/TAP1/SYK/HLA-A/CD40/HLA-DRB1/IKBKG/BAX/BAK1/TAB2/ENTPD1/TAPBPL/MAP2K3/RB1/TRAF3/BLNK/RELB/MAPK14/USP7/CASP3/IRAK4/RAC1/AKT2/POLK/CCND1/E2F3/PLCG2/MAP3K7/CYCS/RUNX3/CASP8/DDB2/CALR/PIK3CA/IKBKB/BCL2/IKBKE/HES1/SAP30L/MAP2K7	6.38007898957567
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	37/1634	82/9376	2.5891273845419	HSPA1A/HSPA1B/HLA-B/LGMN/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/CTSS/HLA-DPB1/HLA-E/B2M/CD4/CD74/HLA-F/HLA-C/CTSB/IFI30/TAPBP/HLA-DQA1/HLA-DOA/CANX/HSPA8/HLA-DQB1/TAP1/HLA-A/HLA-DRB1/NFYC/TAPBPL/CREB1/CIITA/HSPA6/CALR/HSP90AA1/HSPA5/RFX5	6.63971417876286
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	75/1634	227/9376	1.89583681568433	HLA-B/HLA-E/B2M/HLA-F/HLA-C/GNAI2/CXCR4/GNA13/TAPBP/PTGER4/GNB4/IL10RB/RHOA/AKAP13/MAPK1/CREB3L2/EIF4EBP1/CALM3/PIK3R1/ROCK1/BID/TNFRSF1A/TRADD/RAC2/PRKACB/ITGAV/IL6R/CDK6/NFKB1/ADCY7/PRKACA/JAK1/IL10RA/GNB2/GNA12/MAPK13/TAP1/HLA-A/ARHGEF1/IKBKG/GNAI3/PLCB2/BAX/BAK1/CALM2/TAPBPL/GNB1/RB1/PPP3CB/ADCY3/PRKCB/MAPK14/CASP3/ITPR1/RAC1/AKT2/CCND1/CREB1/GSK3B/E2F3/SOS1/SOS2/ITPR2/SP1/CYCS/CASP8/CALR/PIK3CA/IKBKB/GNGT2/SRC/MTOR/VEGFA/ARHGEF11/CCL5	6.27682617771206
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	34/1634	78/9376	2.50120829802592	ITGB2/CYBA/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/NCF2/CYBB/ITGAM/PTPN6/MAPK1/IFNGR1/HLA-DQA1/FCGR1A/STAT1/C3/HLA-DOA/NCF4/NFKB1/JAK1/HLA-DQB1/MAPK13/HLA-DRB1/TAB2/IFNGR2/PRKCB/MAPK14/ITGA4/IRAK4/FCGR3A/MAP3K7/ITGB1	6.11615618978382
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	50/1634	137/9376	2.09418470637636	CTSD/CTSZ/CTSS/CTSB/CTSC/CTSH/MAPK1/TUBA1A/PIK3R1/BID/TNFRSF1A/ACTB/GADD45B/TRADD/XIAP/AIFM1/GADD45G/NFKB1/ACTG1/BCL2L1/PDPK1/SPTAN1/ATM/IKBKG/BAX/BAK1/CFLAR/PARP4/LMNA/BIRC2/DAXX/HTRA2/CASP3/ITPR1/AKT2/CTSO/ITPR2/CSF2RB/CYCS/CASP8/MAP3K5/PIK3CA/IKBKB/BCL2/ERN1/CTSK/TNFRSF10A/CASP10/EIF2AK3/CTSF	5.92684433764132
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	71/1634	224/9376	1.8187620213324	ITGB2/HLA-B/HLA-DMB/TSPO/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-E/B2M/CD4/HLA-F/HLA-C/TLN1/TGFBR1/SPI1/MAPK1/CREB3L2/PIK3R1/HLA-DQA1/TNFRSF1A/XIAP/PRKACB/ITGAL/MMP7/HLA-DOA/STAT5A/NFKB1/CANX/ADCY7/PRKACA/SLC25A5/JAK1/NRP1/VAC14/TGFBR2/HLA-DQB1/HLA-A/BCL2L1/CD40/HLA-DRB1/ATM/IKBKG/CDC26/SMAD2/BAX/RB1/CDC27/PPP3CB/ADCY3/RELB/IL2RG/RANBP3/EP300/AKT2/CCND1/CREB1/E2F3/ZFP36/ANAPC7/ANAPC10/CREBBP/KAT5/CALR/PIK3CA/IKBKB/SMAD4/CRTC2/TLN2/IL15	5.69782063551203
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	69/1634	216/9376	1.83299333605331	HSPA1A/HSPA1B/CYBA/CD36/IL18/NCF2/LY96/OLR1/MMP9/CYBB/RHOA/RAP1A/MAPK1/CALM3/PIK3R1/PYCARD/BID/TNFRSF1A/NCF4/NFKB1/VAV1/HSPA8/MAPK13/CASP1/RAP1B/ABCA1/ARHGEF1/BCL2L1/PDPK1/CD40/IKBKG/PLCB2/BAX/TAB2/NFE2L2/CALM2/CAMK2D/MAP2K3/PPP3CB/TRAF3/MAPK14/CASP3/IRAK4/ITPR1/RAC1/AKT2/GSK3B/MAP3K7/ATF6/HSP90B1/CYCS/CASP8/HSPA6/MAP3K5/PIK3CA/RXRB/IKBKB/BCL2/ERN1/POU2F2/IKBKE/SRC/HSP90AA1/TNFRSF10A/EIF2AK3/ABCG1/CCL5/MAP2K7/HSPA5	5.68991458035229
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	31/1634	70/9376	2.54114355656583	ITGB2/HLA-B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-E/HLA-F/HLA-C/HLA-DQA1/BID/ACTB/RAC2/ITGAL/HLA-DOA/EIF4G3/ACTG1/HLA-DQB1/CD86/HLA-A/CD40/HLA-DRB1/SNTB1/CASP3/RAC1/CCND1/CYCS/CASP8/EIF4G2	5.9455997755035
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	54/1634	157/9376	1.97360235130858	LIPA/CD36/C1QB/PLA2G15/C1QA/NR1H3/C1QC/HAVCR2/PTGER4/LRP1/SIRPA/ITGB5/ALOX5/PTPN6/MAPK1/TMEM30A/RAB5C/ADAM9/ITGAV/ADAM10/SGK1/ATP2A2/MAPKAPK2/MAPK13/VPS41/HIF1A/CASP1/ABCA1/MERTK/ODC1/CPT1A/SPHK1/CAMK2D/RAB14/SIRPB1/RAB7A/MAPK14/VPS18/DUSP2/CASP3/RAC1/VPS16/AXL/CREB1/ATP11A/CEBPB/ELMO1/CALR/VPS33A/ATP11B/DNMT3A/TGFBRAP1/VPS11/ATP11C	5.65164160542619
Organismal Systems	Immune system	hsa04611	Platelet activation	46/1634	126/9376	2.09484952691807	FERMT3/TLN1/APBB1IP/GNAI2/GNA13/RHOA/RAP1A/VAMP8/BTK/MAPK1/PIK3R1/ROCK1/ACTB/PRKACB/LCP2/TBXAS1/PTGS1/ADCY7/PRKACA/ORAI1/ACTG1/PPP1R12A/MAPK13/SYK/RAP1B/FCER1G/ARHGEF1/GNAI3/PLCB2/MYL12A/ADCY3/MAPK14/ITPR1/PIK3R5/AKT2/ARHGAP35/PLCG2/VASP/ITPR2/PIK3CA/ITGB1/PIK3CG/SRC/STIM1/TLN2/PLA2G4C	5.68399807331855
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	32/1634	77/9376	2.38465084487116	TGFBR1/MAPK1/PIK3R1/GADD45B/RAC2/STAT1/CDK6/GADD45G/NFKB1/JAK1/TGFBR2/BCL2L1/IKBKG/SMAD2/BAX/BAK1/RB1/RAC1/AKT2/POLK/CCND1/E2F3/ARAF/DDB2/PIK3CA/IKBKB/PLD1/SMAD4/PLD2/MTOR/VEGFA/ARHGEF6	5.60470288130736
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	74/1634	253/9376	1.67832763266748	ARPC1B/ARPC4/IL18/TLN1/CAPNS1/WIPI2/RHOA/WASF2/MAPK1/PIK3R1/RRAGD/PYCARD/ROCK1/TNFRSF1A/ACTB/TRADD/ACTR3/ARPC2/PRKCD/C3/RRAGC/NFKB1/HK3/ACTG1/ILK/MAPK13/BCL10/CASP1/ATG5/BCL2L1/SHARPIN/BECN1/ATM/IKBKG/HCLS1/PLCB2/BAX/CYTH4/CAST/TAB2/CYTH1/MAP1LC3B/ACTR2/MYL12A/MAPK14/ITPR1/RAC1/ARPC3/AKT2/RIPK2/GSK3B/PLCG2/FOXO3/TLR5/MAP3K7/PFN1/ITPR2/ELMO1/CYCS/ARF1/PIK3CA/ITGB1/IKBKB/BCL2/NLRC4/PIK3C3/ELMO2/SRC/U2AF1L4/MTOR/UBC/TLN2/ARPC5/CCL5	5.02476798134579
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	65/1634	214/9376	1.74287054301696	HLA-B/HLA-E/B2M/CD4/HLA-F/HLA-C/SAMHD1/GNAI2/CXCR4/AP1S2/TAPBP/CFL1/BST2/GNB4/LIMK1/AP1B1/MAPK1/CALM3/PIK3R1/BID/TNFRSF1A/TRADD/RAC2/NFKB1/APOBEC3C/GNB2/MAPK13/RNF7/TAP1/HLA-A/BCL2L1/ATM/TNFRSF1B/IKBKG/GNAI3/BAX/BAK1/TAB2/CALM2/TAPBPL/GNB1/MAP2K3/PPP3CB/PAK2/AP1M1/PRKCB/MAPK14/CASP3/IRAK4/ITPR1/RAC1/AKT2/PLCG2/MAP3K7/ITPR2/AP1G1/CYCS/CASP8/CALR/PIK3CA/IKBKB/BCL2/GNGT2/MTOR/MAP2K7	5.05021609213782
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	39/1634	109/9376	2.05306952039797	HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/CD4/TGFBR1/MAPK1/NFKBIE/IFNGR1/HLA-DQA1/AHR/IL6R/STAT1/HLA-DOA/STAT5A/NFKB1/JAK1/TGFBR2/HLA-DQB1/MAPK13/HIF1A/HLA-DRB1/IKBKG/SMAD2/IFNGR2/PPP3CB/IL4R/IL2RG/MAPK14/IL27RA/STAT6/LAT/RXRB/IKBKB/SMAD4/MTOR/HSP90AA1	5.08025826632
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	58/1634	187/9376	1.77972103495899	CYBA/TXNIP/TRPV2/IL18/CTSB/GABARAP/GPSM3/CYBB/RHOA/IFNAR1/MAPK1/GABARAPL2/PYCARD/XIAP/PRKCD/STAT1/NFKB1/P2RX7/CARD16/JAK1/MAPK13/CASP1/GBP3/GABARAPL1/ATG5/BCL2L1/SHARPIN/IKBKG/PLCB2/PSTPIP1/TAB2/MAP1LC3B/CARD9/TRAF3/CARD6/BIRC2/MAPK14/IRAK4/ITPR1/ANTXR2/TRPM2/RIPK2/GBP5/MAP3K7/ITPR2/GBP1/MFN2/CASP8/GBP4/NEK7/IKBKB/BCL2/NLRC4/IKBKE/RNASEL/MCU/HSP90AA1/CCL5	4.94778715620967
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	43/1634	125/9376	1.9738947368421	CTSD/ASAH1/GNAI2/GNA13/RHOA/MAPK1/CERS6/PIK3R1/DEGS1/ROCK1/BID/TNFRSF1A/TRADD/RAC2/PPP2R5C/NFKB1/SMPD1/GNA12/CERS2/MAPK13/FCER1G/ORMDL2/PDPK1/PPP2CB/PPP2R3C/GNAI3/PLCB2/SPHK1/BAX/SGPL1/ORMDL1/PRKCB/MAPK14/SGMS2/PPP2R5A/RAC1/AKT2/SPTLC2/MAP3K5/PIK3CA/BCL2/PLD1/PLD2	5.03567584012479
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	61/1634	200/9376	1.75011015911873	ARPC1B/ARPC4/IL18/NCKAP1L/CYFIP1/GNA13/NCK1/RHOA/WIPF1/WASF2/PTPN6/MAPK1/TUBA1A/TMBIM6/MYO1F/PYCARD/ROCK1/TNFRSF1A/ACTB/MYO1E/TRADD/ACTR3/ARPC2/NFKB1/ACTG1/MYO5A/GNA12/MAPK13/CASP1/RAB1A/ARHGEF1/IKBKG/HCLS1/TMED10/BAX/BAK1/CYTH4/TAB2/CYTH1/ACTR2/PAK2/MAPK14/SEC24D/CASP3/IRAK4/RAC1/ARPC3/TLR5/MAP3K7/BAIAP2/CYCS/CASP8/ARF1/ITGB1/IKBKB/WIPF3/SRC/SEC24B/TNFRSF10A/ARPC5/ARHGEF11	4.92604555250452
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	23/1634	51/9376	2.58775529795762	ATP6V0D1/ATP6AP1/TCIRG1/ATP6V0B/ATP6V0E1/ATP6V1D/ATP6V0A1/ATP6V1B2/ATP6V1H/ACTB/PRKACB/ATP6V1A/PRKACA/ACTG1/SEC61A1/ATP6V1F/KDELR1/ADCY3/ATP6V0E2/ATP6V1G1/PLCG2/ARF1/KCNQ1	5.22311176649372
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	35/1634	95/9376	2.11402435096309	ITGB2/ACP5/HLA-DMB/HLA-DPA1/HLA-DMA/ATP6V0D1/HLA-DQA2/HLA-DRA/HLA-DPB1/ATP6AP1/IL18/TCIRG1/ATP6V0B/ATP6V0E1/ATP6V1D/TNFSF13B/ATP6V0A1/ATP6V1B2/ATP6V1H/HLA-DQA1/ATP6V1A/ITGAL/HLA-DOA/HLA-DQB1/CD86/HLA-DRB1/ATP6V1F/ATP6V0E2/ATP6V1G1/CSF1/CTSK/TNFRSF11A/VEGFA/CCL5/IL15	5.01353650032147
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	12/1634	18/9376	3.82537739698082	HEXB/HEXA/FUCA1/FUCA2/GLB1/NEU1/MANBA/AGA/MAN2B2/MAN2C1/ENGASE/MAN2B1	5.51196281954428
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	29/1634	73/9376	2.27950570915981	MAPK1/STK4/PIK3R1/GADD45B/CDK6/GADD45G/STAT5A/PDPK1/BAX/BAK1/RB1/PRKCB/AKT2/POLK/CCND1/KIF5B/E2F3/PLCG2/FOXO3/SOS1/SOS2/HGF/ARAF/RASSF1/DDB2/PIK3CA/RXRB/RASSF5/FHIT	5.04170265236365
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	54/1634	173/9376	1.79107265407773	HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/DNAJB1/IL18/IFNAR1/MAPK1/DNAJC3/IFNGR1/PIK3R1/PYCARD/HLA-DQA1/BID/TNFRSF1A/ACTB/TRADD/HNRNPUL1/STAT1/CDK6/HLA-DOA/NFKB1/SLC25A5/JAK1/ACTG1/HLA-DQB1/CASP1/RAB11B/HLA-DRB1/IKBKG/BAX/BAK1/IFNGR2/IFIH1/TRAF3/PRKCB/CASP3/IRAK4/EP300/AKT2/CIITA/CREBBP/CYCS/CASP8/PIK3CA/IKBKB/KPNA1/IKBKE/RNASEL/TLR7/TNFRSF10A/CCL5	4.82458312395219
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	41/1634	120/9376	1.96050591595267	RPS6KA1/MATK/RHOA/RAP1A/MAPK1/NFKBIE/SH2B3/CALM3/PIK3R1/ARHGDIB/RPS6KA3/PRKCD/SORT1/NFKB1/MAPKAPK2/MAPK13/PSEN2/KIDINS220/RAP1B/PDPK1/BAX/CALM2/CAMK2D/PSEN1/ARHGDIA/MAPK14/IRAK4/RAC1/AKT2/RIPK2/RPS6KA2/GSK3B/PLCG2/FOXO3/SOS1/SOS2/MAP3K5/PIK3CA/IKBKB/BCL2/MAP2K7	4.86478974569958
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	34/1634	93/9376	2.09778760479594	HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/CD4/MAPK1/NFKBIE/NOTCH2/IFNGR1/HLA-DQA1/STAT1/HLA-DOA/STAT5A/NFKB1/JAK1/HLA-DQB1/MAPK13/HLA-DRB1/IKBKG/MAML2/MAF/IFNGR2/PPP3CB/IL4R/IL2RG/MAPK14/STAT6/RUNX3/LAT/IKBKB/NOTCH1/MAML3	4.88765679471898
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	35/1634	98/9376	2.04930931981116	GSN/ARPC1B/ARPC4/PTPRC/CFL1/MARCKS/LIMK1/WASF2/MAPK1/PIK3R1/WAS/ASAP1/ACTR3/ARPC2/FCGR1A/RAC2/PRKCD/HCK/VAV1/SYK/SPHK1/ACTR2/PRKCB/RAC1/FCGR3A/ARPC3/AKT2/PLCG2/VASP/LAT/PIK3CA/PLD1/PLD2/PLA2G4C/ARPC5	4.79705242571223
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	12/1634	19/9376	3.62404174450815	HEXB/HEXA/GNS/GUSB/GLB1/NAGLU/IDS/HYAL2/GALNS/HGSNAT/ARSB/SGSH	5.25974035935149
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	21/1634	48/9376	2.51040391676867	ACAA2/ALDH2/ACADM/HADHB/ACAT1/HADHA/ACAA1/BCAT1/IVD/HMGCL/DLD/HADH/IL4I1/ECHS1/ACADS/ALDH3A2/PCCB/MCCC1/HIBCH/MCEE/ACSF3	4.81952829094678
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	27/1634	71/9376	2.18208147292568	ATP6V0D1/ATP6AP1/TCIRG1/ATP6V0B/ATP6V0E1/ATP6V1D/ATP6V0A1/ATP6V1B2/CSK/ATP6V1H/HBEGF/ATP6V1A/ADAM10/NFKB1/MAPK13/IKBKG/ATP6V1F/ATP6V0E2/MAPK14/CASP3/RAC1/ATP6V1G1/PLCG2/IKBKB/GIT1/SRC/CCL5	4.59307436509752
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	48/1634	157/9376	1.75431320116318	NR1H3/CEBPA/SDHD/NDUFS2/NDUFB9/MLX/UQCRC2/SDHB/NDUFB5/PIK3R1/BID/TNFRSF1A/IL6R/NDUFS1/NFKB1/COX7A2L/NDUFS7/NDUFA9/SDHA/MAPK13/SDHC/CYC1/NDUFA10/NDUFS3/BAX/MLXIP/ITCH/IRS2/MAPK14/CASP3/RAC1/UQCRB/COX8A/AKT2/PRKAA1/GSK3B/NDUFB7/NDUFB3/CYCS/CASP8/MAP3K5/ADIPOR2/PIK3CA/IKBKB/COX6A1/ERN1/SREBF1/EIF2AK3	4.37869512690287
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	65/1634	232/9376	1.60764782847254	ITGB2/GSN/TMSB4X/ARPC1B/ARPC4/ITGAX/CXCR4/NCKAP1L/RGCC/CYFIP1/MRAS/FN1/MSN/GNA13/RRAS/CFL1/ITGB5/LIMK1/ITGAM/RHOA/ITGA6/WASF2/ITGAE/MAPK1/PIK3R1/ROCK1/ACTB/ACTR3/ARPC2/IQGAP2/RAC2/ITGAV/ITGAL/ACTG1/PPP1R12A/GNA12/VAV1/ARHGEF1/PIP4K2A/APC/ACTR2/MYL12A/PAK2/ITGA4/DIAPH2/RAC1/ARPC3/AKT2/SSH1/IQGAP1/ARHGAP35/PPP1R12C/SOS1/PFN1/SOS2/ARAF/SLC9A1/BAIAP2/ITGB7/PIK3CA/ITGB1/GIT1/SRC/ARPC5/ARHGEF6	4.30539413414614
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	23/1634	57/9376	2.31536000343576	PPT1/ACAA2/ACADM/HADHB/ACAT1/HADHA/ACAA1/SCP2/HSD17B4/HSD17B12/HADH/ACSL1/ACOX1/ELOVL1/ELOVL5/CPT1A/ECHS1/ACADS/CBR4/ACSF3/ACSL6/MCAT/OXSM	4.57596279517156
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	28/1634	76/9376	2.11402435096309	LPL/DBI/CD36/CYP27A1/NR1H3/FABP5/FABP3/ACADM/OLR1/PCK2/ACAA1/PLTP/SCP2/SLC27A1/ILK/ACSL1/ACOX1/FABP4/PDPK1/CPT1A/ME3/GK/ACOX2/PLIN2/RXRB/ACSL6/UBC/SLC27A4	4.47966034826093
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	38/1634	116/9376	1.87971130713713	FBP1/CAT/SDS/MDH1/ME2/SDHD/ACO2/ACAT1/SDSL/SDHB/ADPGK/IDH3G/SUCLG2/DLD/PGAM1/OGDH/HK3/GLUD1/SDHA/ACOX1/RPE/SDHC/ECHS1/SUCLG1/ACADS/ME3/PGK1/PCCB/GOT2/DLAT/PRPS1/DLST/IDNK/PRPS2/HIBCH/MCEE/PC/GLYCTK	4.37974430087571
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	15/1634	30/9376	2.86903304773562	MDH1/SDHD/ACO2/PCK2/SDHB/IDH3G/SUCLG2/DLD/OGDH/SDHA/SDHC/SUCLG1/DLAT/DLST/PC	4.71031336244555
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	35/1634	105/9376	1.91268869849041	LSP1/MRAS/RRAS/RHOA/MAPK1/CALM3/PIK3R1/PYCARD/PRKCD/STAT1/NFKB1/MAPKAPK2/MAPK13/BCL10/CASP1/SYK/CLEC7A/FCER1G/IKBKG/CALM2/PLK3/CARD9/PPP3CB/RELB/CYLD/MAPK14/ITPR1/AKT2/PLCG2/ITPR2/CASP8/PIK3CA/IKBKB/IKBKE/SRC	4.32055076832685
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	22/1634	55/9376	2.29522643818849	ASAH1/PSAP/HEXB/HEXA/GM2A/GLB1/GLA/CERS6/UGCG/DEGS1/NEU1/ACER3/GALC/SMPD1/CERS2/SPHK1/SGPL1/ARSA/SGMS2/SPTLC2/CERK/SAMD8	4.42568879731469
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	37/1634	115/9376	1.84616039593422	ARRB2/GNAI2/GNA13/RHOA/AKAP13/MAPK1/CREB3L2/HBEGF/PRKACB/MEF2A/SGK1/ADCY7/PRKACA/MAFB/GNA12/NR4A2/ARHGEF1/GNAI3/PLCB2/PDE4A/ARRB1/ADCY3/PRKCB/MEF2D/ITPR1/CREB1/ARAF/ITPR2/SP1/RXRB/BCL2/PLD1/VDR/PLD2/RUNX2/STK39/ARHGEF11	4.19428322465234
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	18/1634	42/9376	2.45917118377339	FTL/TFRC/CYBB/ATG7/PRNP/SAT2/GCLC/ACSL1/ATG5/STEAP3/SLC11A2/MAP1LC3B/GSS/SLC3A2/FTH1/SAT1/SLC39A8/ACSL6	4.35393631370468
Human Diseases	Immune disease	hsa05330	Allograft rejection	17/1634	39/9376	2.50120829802592	HLA-B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-E/HLA-F/HLA-C/HLA-DQA1/HLA-DOA/HLA-DQB1/CD86/HLA-A/CD40/HLA-DRB1	4.31573392182192
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	34/1634	105/9376	1.85804044996211	MRAS/GABARAP/RRAS/GABARAPL2/MITF/RAB5C/CITED2/SAMM50/HIF1A/SMURF2/GABARAPL1/AMFR/BCL2L1/CSNK2A1/BECN1/TFEB/PINK1/MAP1LC3B/RHOT2/CCZ1/RAB7A/TOMM40/MON1B/BCL2L13/FOXO3/RHOT1/SP1/MFN2/NBR1/OPA1/SRC/UBC/TOMM40L/EIF2AK3	4.06185299705261
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	27/1634	77/9376	2.01204915036004	TGFBR1/MAPK1/PIK3R1/GADD45B/CDK6/GADD45G/STAT5A/NFKB1/TGFBR2/BCL2L1/IKBKG/CTBP1/BAX/BAK1/CBL/RB1/AKT2/POLK/CCND1/E2F3/SOS1/SOS2/ARAF/DDB2/PIK3CA/IKBKB/SMAD4	4.09650910195732
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	15/1634	33/9376	2.60821186157783	VAMP8/STX6/STX4/VAMP3/SNAP29/STX7/STX11/STX16/STX18/YKT6/STX5/BET1/VTI1A/VAMP7/BET1L	4.25149954867781
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	37/1634	119/9376	1.78410458430618	MMP9/MAPK1/CREB3L2/PIK3R1/TNFRSF1A/TRADD/XIAP/NFKB1/RHBDF2/MAPK13/TNFRSF1B/IKBKG/CFLAR/TAB2/ITCH/JUNB/MAP2K3/TRAF3/BIRC2/CYLD/MAPK14/CASP3/AKT2/CREB1/MAP3K7/CEBPB/CSF1/MLKL/CASP8/MAP3K5/PIK3CA/IKBKB/CASP10/BAG4/CCL5/IL15/MAP2K7	3.9545532019331
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	36/1634	116/9376	1.78077913307728	ITGB2/CYBA/GNAI2/NCF2/CD99/CXCR4/MSN/MMP9/CYBB/ITGAM/RHOA/RAP1A/PIK3R1/ROCK1/ACTB/RAC2/ITGAL/NCF4/ACTG1/VAV1/MAPK13/RAP1B/GNAI3/SIPA1/MYL12A/PRKCB/MAPK14/ITGA4/RAC1/ARHGAP35/PLCG2/VASP/PIK3CA/ITGB1/RASSF5/CD99L2	3.88719905109148
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	30/1634	91/9376	1.89167014136414	CD81/LILRB4/BTK/PTPN6/MAPK1/NFKBIE/PIK3R1/RAC2/RASGRP3/NFKB1/LILRB3/VAV1/BCL10/SYK/CD72/IKBKG/DAPP1/PPP3CB/BLNK/PRKCB/RAC1/AKT2/GSK3B/PLCG2/SOS1/SOS2/LILRA2/PIK3CA/IKBKB/CD22	3.92662156091081
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	21/1634	56/9376	2.15177478580171	ITGB2/HSPA1A/HSPA1B/IL18/ITGAM/PYCARD/SAR1B/C3/NFKB1/HSPA8/CASP1/RAB1A/CLK1/CASP3/BCL2L13/TLR5/CYCS/CASP8/HSPA6/ARF1/NLRC4	3.97135495045253
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	34/1634	109/9376	1.7898554793213	LY96/IFNAR1/MAPK1/SPP1/PIK3R1/STAT1/TOLLIP/NFKB1/JAK1/MAPK13/CD86/CD40/IKBKG/IRF5/TAB2/MAP2K3/TRAF3/MAPK14/IRAK4/RAC1/AKT2/TLR5/MAP3K7/TLR1/CASP8/PIK3CA/IKBKB/CTSK/IKBKE/TLR7/TLR8/CXCL9/CCL5/MAP2K7	3.81045101989446
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	30/1634	93/9376	1.85098906305524	FN1/ITGA6/PIK3R1/GADD45B/XIAP/ITGAV/CDK6/MAX/GADD45G/NFKB1/BCL2L1/IKBKG/BAX/BAK1/RB1/TRAF3/BIRC2/CASP3/AKT2/POLK/CCND1/E2F3/CYCS/DDB2/PIK3CA/ITGB1/RXRB/IKBKB/BCL2/FHIT	3.78884080864316
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	46/1634	163/9376	1.61933153614526	ATP6AP1/TGFBR1/MMP9/IFNAR1/MAPK1/CREB3L2/PIK3R1/BID/STAT1/STAT5A/NFKB1/JAK1/TGFBR2/MAPK13/IKBKG/BAX/TAB2/MAP2K3/RB1/IFIH1/TRAF3/PRKCB/MAPK14/CASP3/IRAK4/EP300/AKT2/STAT6/CREB1/E2F3/MAP3K7/SOS1/SOS2/ARAF/CREBBP/CYCS/CASP8/DDB2/PIK3CA/IKBKB/BCL2/IKBKE/SRC/SMAD4/CASP10/MAP2K7	3.66438875822118
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	55/1634	204/9376	1.54702762377901	MRAS/FN1/MSN/TIMP3/RRAS/MMP9/ITGB5/RHOA/PTPN6/MAPK1/CD63/PIK3R1/ROCK1/PLAUR/SDC2/ACTB/HBEGF/PRKACB/ITGAV/PRKACA/ACTG1/PPP1R12A/VAV1/MAPK13/HIF1A/ARHGEF1/PDPK1/HCLS1/FLNA/SMAD2/CBL/NUDT16L1/CAMK2D/PRKCB/MAPK14/PLAU/CASP3/ITPR1/RAC1/AKT2/CCND1/IQGAP1/PLCG2/PPP1R12C/SOS1/SOS2/HGF/ARAF/ITPR2/SLC9A1/PIK3CA/ITGB1/SRC/MTOR/VEGFA	3.62892004289729
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	82/1634	333/9376	1.41297723672265	HLA-B/ATP6V0D1/HLA-E/HLA-F/HLA-C/ATP6AP1/BCAP31/FN1/TCIRG1/PTGER4/ATP6V0B/ATP6V0E1/ITGB5/ATP6V1D/ITGA6/ATP6V0A1/IFNAR1/ATP6V1B2/MAPK1/SPP1/CREB3L2/NOTCH2/EIF4EBP1/ATP6V1H/PIK3R1/TNFRSF1A/TRADD/LFNG/PPP2R5C/PRKACB/ITGAV/ATP6V1A/STAT1/CDK6/UBR4/NFKB1/PRKACA/JAK1/UBE3A/HLA-A/RFNG/CHD4/PPP2CB/PPP2R3C/ATM/IKBKG/BAX/BAK1/MAML2/ATP6V1F/TADA3/PSEN1/APC/RB1/TRAF3/ATP6V0E2/CASP3/ITGA4/MFNG/PPP2R5A/EP300/AKT2/ATP6V1G1/CCND1/CREB1/GSK3B/SOS1/SOS2/THBS3/CREBBP/CASP8/ITGB7/PIK3CA/ITGB1/IKBKB/RBL2/IKBKE/HES1/NOTCH1/MTOR/VEGFA/MAML3	3.52514549202587
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	14/1634	32/9376	2.51040391676867	GABARAP/ATG7/WIPI2/GABARAPL2/GABARAPL1/ATG5/PPP2CB/BECN1/ATG4B/ATG2A/PIK3C3/ATG13/MTOR/ULK2	3.93175781099127
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	14/1634	32/9376	2.51040391676867	BID/TNFRSF1A/XIAP/BCL2L1/BECN1/BAX/BAK1/BIRC6/BIRC2/HTRA2/CASP3/CYCS/CASP8/BCL2	3.93175781099127
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	28/1634	87/9376	1.84673391578385	TGFBR1/RHOA/MAPK1/PIK3R1/APPL1/GADD45B/RAC2/GADD45G/TGFBR2/SMAD2/BAX/BAK1/APC/CASP3/RAC1/AKT2/POLK/CCND1/GSK3B/SOS1/SOS2/ARAF/CYCS/DDB2/PIK3CA/BCL2/SMAD4/MTOR	3.64508098198356
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	44/1634	157/9376	1.60812043439958	HLA-B/ZFP36L2/HLA-E/HLA-F/HLA-C/TGFBR1/MRAS/RRAS/MAPK1/EIF4EBP1/CALM3/PIK3R1/SERPINE1/GADD45B/CDK6/RAD50/GADD45G/NFKB1/MAPKAPK2/SLC25A5/TGFBR2/MAPK13/HLA-A/HIPK2/ATM/SMAD2/HUS1/CALM2/MAP2K3/RB1/PPP3CB/MAPK14/ITPR1/AKT2/CCND1/HIPK3/E2F3/FOXO3/ITPR2/PIK3CA/RBL2/RASSF5/MCU/MTOR	3.53006414122066
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	25/1634	75/9376	1.91268869849041	MGST1/MGST2/SLC31A1/MAPK1/PIK3R1/BID/XIAP/BCL2L1/PDPK1/ATM/ERCC1/BAX/BAK1/ATP7A/GSTO1/BIRC2/CASP3/REV3L/AKT2/GSTT1/CYCS/CASP8/MAP3K5/PIK3CA/BCL2	3.64563817401346
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	36/1634	122/9376	1.69319983145053	ATP1B1/MAPK1/NOTCH2/ATP1B3/PIK3R1/ACTB/PRKACB/ITGAV/STAT1/ATP2A2/PRKACA/ACTG1/HIF1A/PDPK1/HDAC3/PLCB2/SLC16A10/MED13/MED13L/PRKCB/EP300/AKT2/CCND1/GSK3B/NCOA2/PLCG2/SLC9A1/CREBBP/NCOA1/PIK3CA/RXRB/THRA/TBC1D4/SRC/NOTCH1/MTOR	3.54045188775111
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	59/1634	227/9376	1.49139162833834	CYBA/MGST1/MGST2/CAT/NCF2/AKR1A1/SDHD/NDUFS2/NDUFB9/UQCRC2/MAPK1/SDHB/NDUFB5/PIK3R1/PRKCD/AHR/NDUFS1/NFKB1/COX7A2L/NDUFS7/SLC25A5/NDUFA9/SDHA/CBR1/MAPK13/HIF1A/PDPK1/SDHC/CYC1/IKBKG/NDUFA10/NDUFS3/NFE2L2/GSTO1/MAPK14/RAC1/UQCRB/COX8A/AKT2/PPIF/NDUFB7/CYP1B1/FOXO3/SOS1/EPHX1/SOS2/HGF/GSTT1/NDUFB3/ARAF/MAP3K5/PIK3CA/IKBKB/COX6A1/PLD1/SRC/PLD2/VEGFA/MAP2K7	3.4430152704837
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	17/1634	44/9376	2.21698008234116	HEXB/HEXA/MAN1A1/MGAT1/MGAT4A/MGAT4B/STT3B/MAN1B1/ALG3/RPN1/ALG2/MAGT1/MAN2A1/MGAT2/ALG14/ALG1/DAD1	3.71712806887909
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	32/1634	105/9376	1.74874395290552	LY96/TNFSF13B/BTK/TNFRSF1A/GADD45B/TRADD/XIAP/GADD45G/NFKB1/BCL10/SYK/BCL2L1/CSNK2A1/CD40/ATM/IKBKG/CFLAR/TAB2/TRAF3/BLNK/PRKCB/BIRC2/RELB/CYLD/PLAU/IRAK4/PLCG2/MAP3K7/LAT/IKBKB/BCL2/TNFRSF11A	3.54445745450414
Human Diseases	Cancer: specific types	hsa05214	Glioma	25/1634	76/9376	1.88752174193133	MAPK1/CAMK1/CALM3/PIK3R1/GADD45B/CDK6/GADD45G/CAMK1D/BAX/BAK1/CALM2/CAMK2D/RB1/PRKCB/AKT2/POLK/CCND1/E2F3/PLCG2/SOS1/SOS2/ARAF/DDB2/PIK3CA/MTOR	3.56885911166315
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	19/1634	52/9376	2.09660107334526	LIPA/APOE/LPL/NPC2/NCEH1/APOC1/TSPO/CD36/SOAT1/CYP27A1/LRP1/PLTP/STARD3/SORT1/STARD3NL/ABCA1/LRPAP1/APOC2/SCARB1	3.6427912676468
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	74/1634	300/9376	1.41538963688291	HSPA1A/HSPA1B/CSF1R/ARRB2/MAP3K2/TGFBR1/MRAS/VEGFB/RRAS/RPS6KA1/HSPB1/MAPKAPK3/RAP1A/MAPK1/DUSP1/STK4/TNFRSF1A/GADD45B/TRADD/RPS6KA3/TAOK3/RAC2/TAOK1/PRKACB/RASGRP3/MAX/GADD45G/NFKB1/MAPKAPK2/DUSP3/PRKACA/LAMTOR3/GNA12/TGFBR2/HSPA8/MAPK13/RAP1B/DUSP10/IKBKG/FLNA/TAB2/PTPN7/ARRB1/MAP2K3/MAP3K13/PPP3CB/PAK2/PRKCB/RELB/DAXX/MAPK14/DUSP2/CASP3/IRAK4/RAC1/AKT2/RPS6KA2/CACNA2D4/MAP3K7/SOS1/SOS2/HGF/PPM1A/ARAF/MAP4K3/CSF1/HSPA6/MAP3K5/IKBKB/PPM1B/PLA2G4C/PPP5C/VEGFA/MAP2K7	3.35934124516464
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	38/1634	133/9376	1.63944745584892	ITGB2/HLA-B/HLA-E/HLA-C/CD48/IFNAR1/PTPN6/MAPK1/TYROBP/IFNGR1/PIK3R1/SH3BP2/BID/RAC2/LCP2/ITGAL/LAT2/VAV1/SYK/HLA-A/FCER1G/ICAM2/IFNGR2/HCST/PPP3CB/PRKCB/CASP3/RAC1/FCGR3A/PLCG2/SOS1/SOS2/ARAF/LAT/PIK3CA/MICA/MICB/TNFRSF10A	3.41200209034062
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/1634	69/9376	1.91268869849041	ALOX5AP/ALOX5/BTK/MAPK1/PIK3R1/RAC2/LCP2/VAV1/MAPK13/SYK/FCER1G/PDPK1/MAP2K3/MAPK14/RAC1/AKT2/PLCG2/SOS1/SOS2/LAT/PIK3CA/PLA2G4C/MAP2K7	3.49564597078765
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	25/1634	78/9376	1.83912374854847	ARPC1B/ARPC4/RHOG/FN1/RHOA/WASF2/PIK3R1/ACTB/ACTR3/ARPC2/ACTG1/ILK/CLTC/HCLS1/CBL/ACTR2/ARHGAP10/RAC1/ARPC3/ELMO1/PIK3CA/ITGB1/ELMO2/SRC/ARPC5	3.41872071679071
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	40/1634	144/9376	1.59390724874201	C1QB/C1QA/C1QC/LY96/ALDH2/ACADM/C5AR1/C2/IL17RA/TNFRSF1A/TRADD/C3AR1/C3/NFKB1/LPIN2/MAPK13/ACOX1/IKBKG/CPT1A/TAB2/MAP2K3/ALDH3A2/TRAF3/MAPK14/CASP3/IRAK4/AKT2/PRKAA1/CCND1/GSK3B/FOXO3/MAP3K7/CASP8/MAP3K5/ADIPOR2/IKBKB/IKBKE/SREBF1/MLYCD/MAP2K7	3.29941583882156
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	21/1634	62/9376	1.943538516208	APH1B/NOTCH2/APH1A/NUMB/LFNG/PTCRA/PSENEN/TLE3/PSEN2/RFNG/SPEN/CTBP1/MAML2/PSEN1/ITCH/MFNG/EP300/CREBBP/HES1/NOTCH1/MAML3	3.42430501568306
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	32/1634	109/9376	1.68456986289064	CD36/NR1H3/RPS6KA1/PCK2/MLX/CREB3L2/PIK3R1/TNFRSF1A/RPS6KA3/PRKCD/SLC27A1/NFKB1/PDPK1/G6PC3/CPT1A/SLC27A3/MLXIP/IRS2/PRKCB/PPARGC1B/AKT2/PRKAA1/RPS6KA2/CREB1/GSK3B/PIK3CA/IKBKB/TBC1D4/SREBF1/CRTC2/MTOR/SLC27A4	3.30252812132424
Human Diseases	Infectious disease: viral	hsa05162	Measles	38/1634	136/9376	1.60328317373461	HSPA1A/HSPA1B/MSN/IFNAR1/PIK3R1/BID/TRADD/CD46/STAT1/CDK6/STAT5A/NFKB1/RAB9A/JAK1/HSPA8/BCL2L1/CSNK2A1/IKBKG/BAX/BAK1/TAB2/IFIH1/TRAF3/IL2RG/CASP3/IRAK4/AKT2/CCND1/GSK3B/MAP3K7/CYCS/CASP8/HSPA6/PIK3CA/IKBKB/BCL2/IKBKE/TLR7	3.25566538396838
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	8/1634	15/9376	3.06030191758466	HEXB/HEXA/GLB1/ST6GALNAC4/ST3GAL5/SLC33A1/B3GALT4/ST6GALNAC6	3.66860078333512
Human Diseases	Immune disease	hsa05310	Asthma	13/1634	32/9376	2.33108935128519	HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/PRG2/HLA-DQA1/HLA-DOA/HLA-DQB1/FCER1G/CD40/HLA-DRB1	3.46498105304134
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	37/1634	133/9376	1.59630410174764	CAT/TGFBR1/GABARAP/PCK2/MAPK1/HOMER3/GABARAPL2/STK4/PIK3R1/GADD45B/SGK3/GADD45G/SGK1/TGFBR2/MAPK13/GABARAPL1/PDPK1/ATM/G6PC3/PLK3/IRS2/MAPK14/USP7/EP300/AKT2/PRKAA1/CCND1/FOXO3/SOS1/SOS2/ARAF/CREBBP/PIK3CA/IKBKB/RBL2/FBXO25/SMAD4	3.18179519369659
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/1634	44/9376	2.08656948926227	HLA-B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-E/HLA-F/HLA-C/HLA-DQA1/HLA-DOA/HLA-DQB1/CD86/HLA-A/HLA-DRB1	3.31880365663384
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	38/1634	140/9376	1.55747508305648	GNAI2/TGFBR1/MRAS/GNA13/RRAS/SLC8A1/GNB4/MAPK1/SPP1/CALM3/SERPINE1/PRKACB/MEF2A/ADCY7/PRKACA/GNB2/BECN1/GNAI3/PLCB2/SPHK1/SMAD2/CALM2/MAP1LC3B/GNB1/ADCY3/MEF2D/ITPR1/PIK3R5/AKT2/PRKAA1/CCND1/ITPR2/SLC9A1/GNGT2/PIK3CG/PIK3C3/SMAD4/MTOR	3.05304072472536
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	24/1634	78/9376	1.76555879860653	ITGB2/C1QB/C1QA/C1QC/GNAI2/LY96/CFL1/IRF8/ITGAM/RHOA/MAPK1/C2/CALM3/PYCARD/C3/NFKB1/MAPK13/CASP1/GNAI3/CALM2/MAPK14/CASP3/IRAK4/ITGB1	3.11900566423592
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/1634	45/9376	2.04020127838977	HLA-B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-E/HLA-F/HLA-C/HLA-DQA1/HLA-DOA/HLA-DQB1/CD86/HLA-A/HLA-DRB1	3.21325081347033
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	21/1634	66/9376	1.82574830310448	HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/IL18/IFNGR1/HLA-DQA1/STAT1/HLA-DOA/NFKB1/HLA-DQB1/HLA-DRB1/SMAD2/MAF/IFNGR2/IL4R/IL2RG/STAT6/TLR5	3.092643768921
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	49/1634	193/9376	1.45681470817664	ARRB2/GNAI2/CXCL16/CXCR4/GNB4/DOCK2/FGR/RHOA/RAP1A/MAPK1/PIK3R1/WAS/ROCK1/RAC2/PRKCD/HCK/PRKACB/STAT1/NFKB1/ADCY7/PRKACA/GNB2/VAV1/RAP1B/IKBKG/GNAI3/PLCB2/PREX1/ARRB1/GNB1/ADCY3/PRKCB/PIK3R5/RAC1/AKT2/GSK3B/PLCG2/FOXO3/SOS1/SOS2/ELMO1/CCL23/PIK3CA/IKBKB/GNGT2/PIK3CG/SRC/CXCL9/CCL5	2.94585605397947
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	38/1634	142/9376	1.53553881428103	CYBA/MGST1/MGST2/NCF2/MMP9/RHOA/DUSP1/CALM3/PIK3R1/TNFRSF1A/SDC2/ACTB/RAC2/ITGAV/MEF2A/NFKB1/ACTG1/MAPK13/IKBKG/SUMO3/NFE2L2/CALM2/GSTO1/MAPK14/RAC1/AKT2/PRKAA1/MAP3K7/GSTT1/HSP90B1/MAP3K5/PIK3CA/IKBKB/BCL2/SRC/HSP90AA1/VEGFA/MAP2K7	2.95410053021489
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	23/1634	75/9376	1.75967360261118	TP53I3/SERPINE1/BID/GADD45B/CD82/CDK6/GADD45G/ZNF385A/STEAP3/BCL2L1/ATM/BAX/CASP3/ZMAT3/CCND1/RRM2B/CYCS/SESN3/CASP8/DDB2/BCL2/TNFRSF10A/MDM4	3.03443560772736
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	15/1634	42/9376	2.04930931981116	CAT/ALDH2/ACAT1/HADHA/AOC1/KYNU/DLD/HADH/IL4I1/ECHS1/ALDH3A2/CYP1B1/DLST/AFMID/HAAO	3.13097325566708
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	17/1634	50/9376	1.95094247246022	HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/CXCR4/TNFSF13B/HLA-DQA1/HLA-DOA/HLA-DQB1/CD86/CD40/HLA-DRB1/ITGA4/ITGB7/IL15	3.09725257282668
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/1634	31/9376	2.22118687566629	OXA1L/SEC63/TMEM208/SEC61A1/SRPRB/SEC62/SEC11A/BAG6/SRP72/SEC11C/SPCS1/HSPA5	3.12866024006422
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	51/1634	205/9376	1.42751888228797	CTSD/CYBA/CD36/NCF2/TGFBR1/SDHD/MMP9/CYBB/NDUFS2/NDUFB9/UQCRC2/SDHB/NDUFB5/PIK3R1/RAC2/PRKCD/MPC1/NDUFS1/ATP2A2/NCF4/NFKB1/COX7A2L/NDUFS7/SLC25A5/NDUFA9/TGFBR2/SDHA/MAPK13/SDHC/CYC1/NDUFA10/NDUFS3/PLCB2/SMAD2/CAMK2D/PDK4/PRKCB/MAPK14/RAC1/UQCRB/COX8A/AKT2/GSK3B/PPIF/NDUFB7/NDUFB3/SP1/PIK3CA/COX6A1/TBC1D4/MTOR	2.84321018136354
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	19/1634	59/9376	1.84785179345684	MAPK1/PIK3R1/GADD45B/GADD45G/ILK/PDPK1/BAX/BAK1/APC/AKT2/POLK/CCND1/GSK3B/FOXO3/SOS1/SOS2/ARAF/DDB2/PIK3CA	3.00118648492798
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	37/1634	139/9376	1.52739888872256	HSPA1A/CTSD/HSPA1B/GNAI2/MMP9/MAPK1/CREB3L2/CALM3/PIK3R1/PRKCD/HBEGF/PRKACB/ADCY7/PRKACA/FKBP5/HSPA8/GNAI3/PLCB2/CALM2/ADCY3/ITPR1/AKT2/CREB1/NCOA2/SOS1/SOS2/ITPR2/POMC/SP1/HSP90B1/NCOA1/HSPA6/PIK3CA/BCL2/KCNJ5/SRC/HSP90AA1	2.8778371823677
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	15/1634	43/9376	2.00165096353648	ACAA2/ALDH2/ACADM/HADHB/ACAT1/HADHA/ACAA1/HADH/ACSL1/ACOX1/CPT1A/ECHS1/ACADS/ALDH3A2/ACSL6	3.02430152749219
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	29/1634	103/9376	1.61557200746278	C1QB/C1QA/C1QC/GNAI2/TGFBR1/MAPK1/IFNGR1/PIK3R1/SERPINE1/TNFRSF1A/C3/NFKB1/TGFBR2/MAPK13/PPP2CB/IKBKG/GNAI3/PLCB2/SMAD2/CFLAR/IFNGR2/MAPK14/IRAK4/AKT2/CASP8/CALR/PIK3CA/IKBKB/CCL5	2.88584117599939
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	11/1634	28/9376	2.25424025179227	PPT1/ACAA2/HADHB/HADHA/HSD17B12/ACOT2/HADH/ELOVL1/ELOVL5/ECHS1/ACOT4	3.05341249816925
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	11/1634	28/9376	2.25424025179227	ATP6V0D1/TCIRG1/ATP6V0E1/ATP6V1D/ATP6V0A1/ATP6V1B2/ATP6V1A/ATP6V1F/ATP6V0E2/ATP6V1G1/SLC12A7	3.05341249816925
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	18/1634	56/9376	1.84437838783004	MAN1A1/MGAT1/MGAT4A/SRD5A3/MGAT4B/STT3B/MAN1B1/ALG3/RPN1/ALG2/MAGT1/DPAGT1/MAN2A1/ALG8/MGAT2/ALG14/ALG1/DAD1	2.91144269860866
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	28/1634	100/9376	1.60665850673195	CD9/HLA-DMB/CD36/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/CD37/HLA-DPB1/CD4/CSF1R/TFRC/ITGAM/ITGA6/HLA-DQA1/FCGR1A/CD33/ANPEP/IL6R/HLA-DOA/HLA-DQB1/HLA-DRB1/CSF3R/CD59/IL4R/ITGA4/CSF1/CD22	2.8018765895813
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	63/1634	268/9376	1.34887374632346	GNAI2/SDHD/NDUFS2/NDUFB9/UQCRC2/TUBA1A/DUSP1/SDHB/SLC39A11/NDUFB5/CALM3/PRKACB/PSMD9/NDUFS1/SLC39A3/PRKACA/SNCA/COX7A2L/NDUFS7/SLC25A5/NDUFA9/SDHA/BCL2L1/UBE2L6/SDHC/CYC1/NDUFA10/PINK1/NDUFS3/GNAI3/BAX/SLC39A1/SLC11A2/NFE2L2/CALM2/CAMK2D/UBE2G1/DAXX/HTRA2/TRAP1/CASP3/ITPR1/UQCRB/COX8A/SLC39A13/KIF5B/PPIF/NDUFB7/SLC39A6/ATF6/NDUFB3/ITPR2/CYCS/MFN2/MAP3K5/COX6A1/ERN1/SLC39A8/MCU/UBC/LRRK2/EIF2AK3/HSPA5	2.66200738342826
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	21/1634	70/9376	1.72141982864137	CD36/PCK2/NFKBIE/APPL1/TNFRSF1A/TRADD/NFKB1/ACSL1/TNFRSF1B/IKBKG/G6PC3/CPT1A/IRS2/AKT2/PRKAA1/POMC/ADIPOR2/RXRB/IKBKB/ACSL6/MTOR	2.78317587802904
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	49/1634	201/9376	1.39883203322433	CSF1R/ID2/SPI1/CEBPA/PBX3/MMP9/ITGAM/BMP2K/SPINT1/MITF/GADD45B/FCGR1A/PTCRA/MAX/GADD45G/NFKB1/JMJD1C/REL/NR4A3/KMT2A/TGFBR2/CD86/BCL2L1/LMO2/CD40/ATM/ETV6/BAX/BAK1/CDK9/MAF/BIRC2/PLAU/POLK/CDK14/FLI1/CEBPB/CCNT1/SP1/ITGB7/DDB2/RXRB/NUPR1/DOT1L/AFF1/CCNT2/SUPT3H/RUNX2/BMI1	2.62585116033422
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	40/1634	158/9376	1.45267496087879	CAB39/RPS6KA1/ATP6V1D/RHOA/ATP6V1B2/MAPK1/EIF4EBP1/ATP6V1H/PIK3R1/RRAGD/TNFRSF1A/RPS6KA3/ATP6V1A/RRAGC/LAMTOR1/SGK1/LAMTOR3/LAMTOR2/LPIN2/PDPK1/ATP6V1F/SLC3A2/PRKCB/LAMTOR4/FNIP1/AKT2/PRKAA1/ATP6V1G1/RPS6KA2/GSK3B/SOS1/SOS2/FLCN/DDIT4/MIOS/PIK3CA/IKBKB/MTOR/ULK2/PRR5L	2.63622057414447
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	26/1634	93/9376	1.60419052131454	TGFBR1/RHOA/RAP1A/WASF2/PTPN6/MAPK1/WAS/ROCK1/ACTB/RAC2/ACTG1/CCM2/TGFBR2/SMURF2/RAP1B/CSNK2A1/MYL12A/EP300/RAC1/IQGAP1/MAP3K7/BAIAP2/CREBBP/SRC/SMAD4/SNAI1	2.69002482256734
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	27/1634	98/9376	1.58089576099718	CALM3/PIK3R1/CDS2/MTMR14/DGKZ/PPIP5K2/PIP4K2A/PLCB2/CALM2/SACM1L/MTMR6/PRKCB/ITPK1/ITPR1/ITPKB/PLCG2/ITPR2/IMPA1/DGKH/PIK3CA/INPP1/PI4KB/MTMR3/PIK3C3/DGKQ/INPP4A/MTM1	2.6556396352974
NA	NA	hsa04518	Integrin signaling	39/1634	154/9376	1.45314660859336	ITGB2/FERMT3/LIMS1/TLN1/ITGAX/FN1/VEGFB/ITGB5/ITGAM/PARVG/ITGA6/ITGAE/PARVB/SPP1/PIK3R1/ACTB/RAC2/ITGAV/ITGAL/C3/ACTG1/ILK/FLNA/ICAM2/ITGA4/RAC1/AKT2/CCND1/GSK3B/HGF/THBS3/ITGB7/PIK3CA/ITGB1/SRC/MTOR/TLN2/VEGFA/ARHGEF6	2.60478340481435
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	17/1634	54/9376	1.80642821524094	HLA-B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-E/HLA-F/HLA-C/HLA-DQA1/HLA-DOA/HLA-DQB1/CD86/HLA-A/CD40/HLA-DRB1	2.73019159823325
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	86/1634	388/9376	1.27183939229517	APOE/LPL/RTN4/SDHD/LRP1/APH1B/CYBB/RTN3/NDUFS2/NDUFB9/WIPI2/UQCRC2/MAPK1/TUBA1A/SDHB/SLC39A11/NDUFB5/CALM3/PIK3R1/APH1A/BID/TNFRSF1A/PSENEN/PSMD9/ADAM10/NDUFS1/SLC39A3/ATP2A2/NFKB1/SNCA/COX7A2L/NDUFS7/SLC25A5/NDUFA9/CDK5/SDHA/PSEN2/CSNK2A1/BECN1/SDHC/CYC1/IKBKG/NDUFA10/NDUFS3/PLCB2/SLC39A1/SLC11A2/CALM2/PSEN1/APC/IRS2/PPP3CB/CASP3/ITPR1/UQCRB/COX8A/AKT2/BACE1/SLC39A13/KIF5B/GSK3B/PPIF/NDUFB7/SLC39A6/ATF6/NDUFB3/ARAF/ITPR2/CSF1/CYCS/IDE/CASP8/MAP3K5/PIK3CA/IKBKB/COX6A1/ERN1/SLC39A8/ATG2A/PIK3C3/MCU/ATG13/MTOR/ULK2/EIF2AK3/MAP2K7	2.51235960730532
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	82/1634	368/9376	1.27859081475174	GPX1/CHCHD10/CAT/SDHD/ANXA11/DERL1/NDUFS2/NDUFB9/WIPI2/UQCRC2/TUBA1A/RANBP2/SDHB/NDUFB5/BID/TNFRSF1A/ACTB/NUP214/ACTR1A/PSMD9/NDUFS1/ACTR10/COX7A2L/NDUFS7/NDUFA9/ACTG1/SDHA/MAPK13/CASP1/RAB1A/BCL2L1/BECN1/SDHC/CYC1/TNFRSF1B/NDUFA10/PINK1/NDUFS3/WDR41/BAX/MAP1LC3B/MAP2K3/SETX/POM121/FIG4/PPP3CB/TOMM40/DAXX/MAPK14/SPG11/CASP3/RAC1/UQCRB/COX8A/ACTR1B/KIF5B/NDUFB7/ATF6/PFN1/ATXN2L/NDUFB3/NUP210/CYCS/ANG/NUP85/MAP3K5/BCL2/COX6A1/ERN1/ATG2A/PIK3C3/NUP160/MCU/ATG13/MTOR/NUP107/TOMM40L/ULK2/UBQLN2/EIF2AK3/DNAL4/HSPA5	2.50473390656572
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	49/1634	203/9376	1.38505043683788	ZYX/TLN1/FN1/VEGFB/ITGB5/PARVG/RHOA/RAP1A/ITGA6/PARVB/MAPK1/SPP1/PIK3R1/ROCK1/ACTB/XIAP/RAC2/ITGAV/ACTG1/PPP1R12A/VAV1/ILK/RAP1B/PDPK1/EMP1/FLNA/MYL12A/PAK2/PRKCB/BIRC2/ITGA4/RAC1/AKT2/CCND1/ARHGAP35/GSK3B/PPP1R12C/SOS1/SOS2/HGF/VASP/THBS3/ITGB7/PIK3CA/ITGB1/BCL2/SRC/TLN2/VEGFA	2.54797418408941
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	19/1634	63/9376	1.73052787006275	ALDH2/COLGALT1/ACAT1/HADHA/PLOD3/DLD/SETDB2/KMT2A/HADH/ECHS1/PLOD1/ALDH3A2/PHYKPL/KMT2B/DLST/PRDM2/EHMT2/DOT1L/SETDB1	2.67268233511585
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	32/1634	122/9376	1.50506651684491	CSH1/GNAI2/MAPK1/CREB3L2/PIK3R1/CSH2/PRKACB/STAT1/STAT5A/ADCY7/PRKACA/MAPK13/GNAI3/PLCB2/JUNB/MAP2K3/IRS2/ADCY3/PRKCB/MAPK14/ITPR1/EP300/AKT2/CREB1/GSK3B/PLCG2/SOS1/SOS2/ITPR2/CREBBP/PIK3CA/MTOR	2.57957896392113
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	27/1634	99/9376	1.5649271169467	WASF2/MAPK1/EIF4EBP1/PIK3R1/WAS/RAC2/DGKZ/CHPT1/HIF1A/PDPK1/GPCPD1/PCYT1A/PRKCB/RAC1/AKT2/SLC44A1/SOS1/SOS2/SP1/DGKH/PIK3CA/PLD1/PLD2/MTOR/PLA2G4C/DGKQ/SLC22A4	2.59592010218618
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	13/1634	38/9376	1.96302261160858	HEXB/HEXA/GNPDA1/RENBP/AMDHD2/HK3/GALE/NAGK/UAP1L1/PMM2/CHIT1/MPI/GALT	2.73266521607814
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	36/1634	142/9376	1.45472098195045	UBE2E2/UBE2F/XIAP/UBE2B/TRIP12/RNF7/STUB1/UBE2W/SMURF2/UBE3A/UBE2Q1/UBE2L6/UBE4A/CDC26/CBL/BIRC6/CUL2/UBE2G1/ITCH/PIAS1/CDC27/BIRC2/ANAPC7/PIAS2/ANAPC10/UBE4B/HERC2/WWP1/HERC4/DDB2/SYVN1/RHOBTB2/UBC/HERC3/MGRN1/UBE2O	2.50829904025361
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	49/1634	205/9376	1.37153774964922	GSN/HLA-B/ATP6V0D1/HLA-E/HLA-F/HLA-C/RHOA/MAPK1/CREB3L2/YWHAH/PIK3R1/TRADD/PRKACB/C3/CDK6/UBR4/STAT5A/NFKB1/MAPKAPK2/PRKACA/REL/JAK1/VAC14/SYK/UBE3A/HLA-A/CHD4/HDAC3/IKBKG/YWHAG/MRPS18B/BAX/BAK1/RB1/GTF2A1/TRAF3/USP7/CASP3/EP300/RAC1/CCND1/CREB1/HDAC7/CREBBP/CASP8/PIK3CA/RBL2/SRC/HDAC10	2.47090820155174
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	18/1634	60/9376	1.72141982864137	HSPB1/MAPKAPK3/MAPK1/PIK3R1/RAC2/MAPKAPK2/MAPK13/SPHK1/PPP3CB/PRKCB/MAPK14/RAC1/AKT2/PLCG2/PIK3CA/SRC/PLA2G4C/VEGFA	2.57533684361042
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	35/1634	138/9376	1.45530661841662	ATP6V0D1/ATP6AP1/SDHD/TCIRG1/ATP6V0B/ATP6V0E1/ATP6V1D/NDUFS2/NDUFB9/ATP6V0A1/ATP6V1B2/UQCRC2/ATP6V1H/SDHB/NDUFB5/ATP6V1A/NDUFS1/COX7A2L/NDUFS7/NDUFA9/SDHA/PPA2/SDHC/CYC1/NDUFA10/NDUFS3/ATP6V1F/ATP6V0E2/UQCRB/COX8A/ATP6V1G1/NDUFB7/NDUFB3/CYCS/COX6A1	2.47536706541601
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	11/1634	31/9376	2.03608796936076	ALDH2/HADHA/DPYD/ALDH3B1/ACOX1/CNDP2/ECHS1/ACADS/ALDH3A2/HIBCH/MLYCD	2.65443995471969
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	27/1634	101/9376	1.53393846116558	TGFBR1/FN1/VEGFB/CYBB/MAPK1/PIK3R1/SERPINE1/PRKCD/STAT1/STAT5A/NFKB1/TGFBR2/MAPK13/PLCB2/SMAD2/BAX/PRKCB/MAPK14/CASP3/RAC1/AKT2/CCND1/PLCG2/PIK3CA/BCL2/SMAD4/VEGFA	2.47844915617375
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	23/1634	83/9376	1.5900665083836	CAT/GSTK1/ACAA1/SCP2/HMGCL/AGPS/HSD17B4/ABCD1/ACSL1/ACOX1/DHRS4/PEX13/PEX16/ABCD4/PEX11B/NUDT19/ACOX2/FAR1/FAR2/ACSL6/MLYCD/MPV17L2/PRDX1	2.48054507744357
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	25/1634	93/9376	1.54249088587936	MAP3K2/MAPK1/CALM3/PRKCD/HBEGF/PRKACB/ADCY7/PRKACA/MAPK13/PLCB2/CALM2/CAMK2D/MAP2K3/ADCY3/PRKCB/MAPK14/ITPR1/SOS1/SOS2/ITPR2/PLD1/SRC/PLD2/PLA2G4C/MAP2K7	2.41532082604838
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	39/1634	160/9376	1.39865361077111	ITGB2/HLA-B/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/ALCAM/HLA-DPB1/HLA-E/CD4/PTPRC/HLA-F/HLA-C/CD99/CADM1/ITGAM/ITGA6/SPN/HLA-DQA1/GLG1/SDC2/ITGAV/ITGAL/CD276/HLA-DOA/CD58/HLA-DQB1/CD86/HLA-A/CD40/HLA-DRB1/ICAM2/ITGA4/ITGB7/ITGB1/SDC3/CD22/CD99L2	2.33652020607722
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/1634	32/9376	1.97246022031824	HADHA/SUCLG2/DLD/ACOX1/ECHS1/SUCLG1/ACADS/PCCB/HIBCH/MCEE/MLYCD	2.53142753714146
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	22/1634	80/9376	1.57796817625459	MAPK1/EIF4EBP1/PIK3R1/IL6R/JAK1/BCL2L1/BAX/PRKCB/AKT2/AXL/GSK3B/PLCG2/FOXO3/SOS1/SOS2/HGF/ARAF/PIK3CA/BCL2/SRC/MTOR/VEGFA	2.38498659825205
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	31/1634	122/9376	1.45803318819351	CD36/FBP1/CAB39/PCK2/CREB3L2/EIF4EBP1/PIK3R1/PPP2R5C/TBC1D1/PDPK1/PPP2CB/PPP2R3C/RAB11B/G6PC3/CPT1A/RAB14/IRS2/PPP2R5A/AKT2/PRKAA1/CCND1/CREB1/FOXO3/MAP3K7/PFKFB3/ADIPOR2/PIK3CA/SREBF1/CRTC2/MTOR/MLYCD	2.33936073296363
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	31/1634	122/9376	1.45803318819351	CD4/PTPRC/NCK1/RHOA/PTPN6/MAPK1/NFKBIE/PIK3R1/PPP2R5C/LCP2/NFKB1/VAV1/MAPK13/BCL10/PDPK1/PPP2CB/PPP2R3C/IKBKG/PPP3CB/PAK2/MAPK14/PPP2R5A/AKT2/GSK3B/MAP3K7/SOS1/SOS2/LAT/PIK3CA/IKBKB/MAP2K7	2.33936073296363
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	18/1634	62/9376	1.66589015674971	HSPA1A/HSPA1B/CAT/PIK3R1/PRKACB/ADCY7/PRKACA/HSPA8/ATG5/IRS2/ADCY3/AKT2/PRKAA1/FOXO3/CLPB/HSPA6/PIK3CA/MTOR	2.41665916598296
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	62/1634	275/9376	1.29367308334261	HSPA1A/HSPA1B/CYBA/C1QB/C1QA/C1QC/NCF2/SDHD/CYBB/NDUFS2/PRNP/NDUFB9/UQCRC2/MAPK1/TUBA1A/CREB3L2/SDHB/NDUFB5/PIK3R1/RAC2/PRKCD/PRKACB/PSMD9/NDUFS1/NCF4/PRKACA/COX7A2L/NDUFS7/SLC25A5/NDUFA9/HSPA8/SDHA/MAPK13/CSNK2A1/SDHC/CYC1/NDUFA10/NDUFS3/BAX/PPP3CB/MAPK14/CASP3/ITPR1/RAC1/UQCRB/COX8A/KIF5B/CREB1/GSK3B/PPIF/NDUFB7/NDUFB3/ITPR2/CYCS/HSPA6/PIK3CA/COX6A1/MCU/NOTCH1/EIF2AK3/CCL5/HSPA5	2.27075883994242
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	54/1634	235/9376	1.31853433683169	MGLL/SDHD/RPS6KA1/NDUFS2/NDUFB9/UQCRC2/CREB3L2/SDHB/NDUFB5/ACTB/RPS6KA3/PRKACB/NDUFS1/ADCY7/PRKACA/COX7A2L/NDUFS7/NDUFA9/ACTG1/SDHA/MAPK13/ACSL1/SDHC/CYC1/NDUFA10/NDUFS3/SLC25A20/CPT1A/COX14/COA5/MAP2K3/SMARCC2/ADCY3/ARID1A/NDUFAF1/MAPK14/PNPLA2/UQCRB/COX8A/PRKAA1/RPS6KA2/CREB1/NDUFB7/SOS1/SOS2/NDUFB3/MAP3K5/COX6A1/ACSL6/SLC25A29/KDM3B/SIRT6/MTOR/NDUFAF5	2.2718435057466
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	21/1634	76/9376	1.58551826322232	ATP1B1/GNAI2/ATP1B3/CALM3/ACTB/PRKACB/ADCY7/PRKACA/ACTG1/SLC4A2/GNAI3/PLCB2/CALM2/CAMK2D/ADCY3/PRKCB/ITPR1/ITPR2/SLC9A1/KCNJ2/KCNQ1	2.35445746286611
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	19/1634	67/9376	1.62721277334259	RPS6KA1/RAP1A/MAPK1/CALM3/RPS6KA3/PRKACB/PRKACA/RAP1B/PLCB2/CALM2/CAMK2D/PPP3CB/PRKCB/ITPR1/EP300/RPS6KA2/ARAF/ITPR2/CREBBP	2.36693243654363
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	5/1634	10/9376	2.86903304773562	PAPSS1/ETHE1/PAPSS2/MPST/BPNT1	2.71659554787152
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	16/1634	54/9376	1.70016773199148	SDS/MDH1/SDSL/BCAT1/GCLC/LACC1/IL4I1/MAT2B/GSS/AMD1/AHCYL1/MPST/GOT2/MTR/SMS/DNMT3A	2.37044292735469
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/1634	21/9376	2.1859299411319	CHST11/DSE/CSGALNACT2/B3GAT3/B4GALT7/B3GALT6/CHST12/CHST7	2.49937755866556
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1634	68/9376	1.60328317373461	CSF1R/SPI1/CEBPA/ITGAM/MAPK1/EIF4EBP1/PIK3R1/FCGR1A/STAT5A/NFKB1/IKBKG/AKT2/CCND1/SOS1/SOS2/ARAF/PIK3CA/IKBKB/MTOR	2.29367859854042
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	20/1634	73/9376	1.57207290286883	CD4/SAMHD1/CXCR4/MDFIC/BST2/SERINC3/ELL2/RANBP2/PDCD6IP/APOBEC3C/NELFE/AFF4/CDK9/EP300/CCNT1/CREBBP/CPSF7/NELFA/CCNT2/PPIA	2.25416850514336
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	27/1634	106/9376	1.46158287337475	MMP9/MAPK1/CREB3L2/SPINT1/PIK3R1/NFKB1/PDPK1/IKBKG/RB1/PLAU/EP300/AKT2/CCND1/CREB1/GSK3B/E2F3/SOS1/SOS2/ARAF/CREBBP/HSP90B1/PIK3CA/IKBKB/BCL2/SLC46A1/MTOR/HSP90AA1	2.19557275370704
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	32/1634	130/9376	1.41244703888523	ARRB2/GNAI2/TGFBR1/VEGFB/MMP9/GNB4/MAPK1/CREB3L2/PIK3R1/PRKACB/NFKB1/ADCY7/PRKACA/GNB2/TGFBR2/MAPK13/GNAI3/PLCB2/SMAD2/ARRB1/GNB1/ADCY3/MAPK14/AKT2/CREB1/SOS1/SOS2/PIK3CA/GNGT2/SRC/VEGFA/MAP2K7	2.17544447173284
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/1634	18/9376	2.23147014823881	MMADHC/LMBRD1/ABCD4/MTR/TCN2/THAP11/PRDX1	2.40244636972195
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	37/1634	156/9376	1.36095157392587	CD81/NR1H3/IFNAR1/MAPK1/YWHAH/PIK3R1/BID/TNFRSF1A/TRADD/STAT1/CDK6/NFKB1/JAK1/PPP2CB/IKBKG/YWHAG/BAX/BAK1/CFLAR/PIAS1/RB1/TRAF3/SCARB1/CASP3/AKT2/CCND1/GSK3B/E2F3/SOS1/SOS2/ARAF/CYCS/CASP8/PIK3CA/IKBKB/IKBKE/RNASEL	2.08848259045722
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	49/1634	217/9376	1.29569234413867	MGST1/MGST2/ARRB2/GNAI2/KPNA3/RPS6KA1/KLF4/MAPK1/CREB3L2/NOTCH2/EIF4EBP1/PIK3R1/RPS6KA3/XIAP/AHR/PRKACB/STAT5A/NFKB1/ADCY7/PRKACA/KPNA4/GNAI3/ARRB1/GSTO1/RB1/KPNB1/ADCY3/PRKCB/AKT2/CCND1/RPS6KA2/CREB1/CYP1B1/SOS1/EPHX1/SOS2/GSTT1/HSP90B1/PIK3CA/RXRB/BCL2/KPNA1/VDR/IKBKE/PAQR8/SRC/MTOR/HSP90AA1/VEGFA	2.02456161465837
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	25/1634	99/9376	1.44900658976546	MMP9/MAPK1/NOTCH2/PIK3R1/HBEGF/PRKACB/ADCY7/PRKACA/MAPK13/BAX/RB1/ADCY3/MAPK14/AKT2/CCND1/E2F3/SOS1/SOS2/ARAF/SP1/PIK3CA/BCL2/SRC/NOTCH1/MTOR	2.0632488641826
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	25/1634	99/9376	1.44900658976546	ITGB2/HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/C1QB/C1QA/C1QC/ITGAM/C5AR1/C2/HLA-DQA1/FPR3/PTAFR/FCGR1A/ITGAL/C3AR1/C3/HLA-DOA/HLA-DQB1/HLA-DRB1/CFD/FCGR3A	2.0632488641826
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/1634	31/9376	1.85098906305524	CAT/MDH1/GRHPR/ACO2/ACAT1/DLD/PCCB/MCEE/AFMID/GLYCTK	2.18021966937516
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	23/1634	90/9376	1.46639466884265	CAT/CREB3L2/EIF4EBP1/PIK3R1/APPL1/PRKACB/NFKB1/ADCY7/PRKACA/ATG5/BAX/IRS2/ADCY3/AKT2/PRKAA1/CREB1/FOXO3/SESN3/ADIPOR2/PIK3CA/EHMT2/ATG13/MTOR	2.04242244005188
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/1634	27/9376	1.91268869849041	ACAA1/SCP2/HSD17B4/HSD17B12/ACOT2/ACOX1/ELOVL1/ELOVL5/ACOT4	2.1817604050474
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	36/1634	154/9376	1.34136610024003	DHRS3/AKR1A1/ALDH2/GUSB/NME4/BCAT1/PPCS/NME3/KYNU/CMPK1/ALAS1/DLD/VKORC1/GCLC/UROS/COQ2/MAT2B/AK3/MOCS2/GSS/NADK/PNPO/ALDH3A2/PDXK/SPR/PMM2/FECH/NADSYN1/AFMID/HAAO/MPI/FLAD1/OXSM/NFS1/NME7/COQ7	1.96224518954601
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	99/1634	480/9376	1.18347613219094	GPX1/CAT/SDHD/DERL1/CYBB/NDUFS2/PRNP/NDUFB9/WIPI2/UQCRC2/MAPK1/TUBA1A/SDHB/NDUFB5/CALM3/BID/TNFRSF1A/ACTR1A/PSMD9/NDUFS1/ACTR10/ATP2A2/NFKB1/SNCA/COX7A2L/NDUFS7/SLC25A5/NDUFA9/CDK5/SDHA/MAPK13/PSEN2/RAB1A/BCL2L1/CSNK2A1/UBE2L6/BECN1/SDHC/CYC1/TNFRSF1B/NDUFA10/PINK1/NDUFS3/PLCB2/WDR41/BAX/BAK1/CALM2/CAMK2D/MAP1LC3B/UBE2G1/PSEN1/APC/MAP2K3/FIG4/PPP3CB/PRKCB/TOMM40/DAXX/MAPK14/SPG11/HTRA2/TRAP1/CASP3/ITPR1/RAC1/UQCRB/COX8A/ACTR1B/KIF5B/GSK3B/PPIF/NDUFB7/ATF6/ATXN2L/NDUFB3/ARAF/ITPR2/CSF1/CYCS/MFN2/CASP8/MAP3K5/BCL2/COX6A1/ERN1/ATG2A/PIK3C3/MCU/ATG13/MTOR/UBC/TOMM40L/ULK2/LRRK2/EIF2AK3/DNAL4/MAP2K7/HSPA5	1.89577978799437
NA	NA	hsa04517	IgSF CAM signaling	64/1634	299/9376	1.22821481642194	ITGB2/CD84/ARPC1B/ARPC4/ITGAX/MSN/MBP/CD48/NCK1/CADM1/ITGAM/RHOA/RAP1A/PTPN6/MAPK1/TUBA1A/CSK/EPB41L3/DOK2/PIK3R1/ACTB/PMP22/ACTR3/ARPC2/EPB41L2/DOK1/LCP2/ITGAL/NRP1/ACTG1/VAV1/MAPK13/CD86/RAP1B/PDPK1/NRP2/SPTAN1/PPFIA1/ICAM2/SLAMF7/ACTR2/MYL12A/PAK2/PRKCB/MAPK14/ITGA4/GLDN/RAC1/ARPC3/AKT2/MYL6/IQGAP1/GSK3B/PLCG2/CRTAM/LRFN4/BAIAP2/PIK3CA/ITGB1/PLXNA1/GIT1/SRC/ARPC5/EPB41L1	1.84243995869791
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/1634	41/9376	1.67943397916231	MMP9/MAPK1/HBEGF/DAPK1/RB1/CCND1/E2F3/ARAF/RASSF1/SRC/DAPK3/VEGFA	2.00293617586383
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/1634	50/9376	1.60665850673195	ALDH2/AOC1/LAP3/SAT2/CNDP2/ODC1/OAT/AMD1/ALDH3A2/GOT2/SMS/SAT1/GATM/L3HYPDH	1.97590777067886
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	20/1634	78/9376	1.47129899883878	MTMR14/PPIP5K2/PIP4K2A/PLCB2/SACM1L/FIG4/MTMR6/ITPK1/ITPKB/PLCG2/IMPA1/PIK3CA/INPP1/MINPP1/PI4KB/PIK3CG/MTMR3/PIK3C3/INPP4A/MTM1	1.92014545401676
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	47/1634	212/9376	1.27211842682617	ITGB2/CSF1R/TLN1/APBB1IP/GNAI2/EVL/MRAS/VEGFB/RRAS/ITGAM/RHOA/RAP1A/MAPK1/CALM3/PIK3R1/ACTB/RAC2/RASGRP3/LCP2/ITGAL/DOCK4/ADCY7/ACTG1/VAV1/MAPK13/RAP1B/GNAI3/PLCB2/SIPA1/CALM2/MAP2K3/ADCY3/PRKCB/MAPK14/RAC1/AKT2/PFN1/HGF/VASP/CSF1/LAT/PIK3CA/ITGB1/RASSF5/SRC/TLN2/VEGFA	1.84106203567587
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	14/1634	51/9376	1.57515539875681	PLD3/PLA2G7/AGPS/CHPT1/CEPT1/TMEM86A/LPCAT2/PAFAH1B1/PAFAH1B2/PLA2G12A/PLD1/PLD2/PAFAH2/PLA2G4C	1.8920427692311
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	31/1634	133/9376	1.33744397713991	ARRB2/GNAI2/GNB4/CREB3L2/CALM3/PPP2R5C/PRKACB/PRKACA/GNB2/MAPK13/PPP2CB/PPP2R3C/GNAI3/PLCB2/CALM2/CAMK2D/COMT/ARRB1/GNB1/PPP3CB/PRKCB/MAPK14/ITPR1/PPP2R5A/AKT2/KIF5B/CREB1/GSK3B/ITPR2/GNGT2/KCNJ5	1.80055381383244
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	18/1634	70/9376	1.47550271026403	RAP1A/MAPK1/PIK3R1/HIF1A/RAP1B/CUL2/PAK2/EP300/RAC1/AKT2/SOS1/SOS2/HGF/ARAF/CREBBP/FLCN/PIK3CA/VEGFA	1.8344487087867
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/1634	104/9376	1.37934281141135	PLD3/PLA2G15/LPGAT1/CDS2/AGPAT2/DGKZ/CHPT1/LPIN2/ETNK1/CEPT1/GPCPD1/PNPLA6/LPCAT2/CRLS1/PCYT1A/AGPAT4/SGMS2/MBOAT1/DGKH/SAMD8/PLA2G12A/PLD1/PLD2/PLA2G4C/DGKQ	1.78709194586327
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1634	154/9376	1.30410593078892	GNAI2/RGS2/RHOA/MAPK1/CAMK1/CALM3/ROCK1/ACTB/PRKACB/ADCY7/PRKACA/ACTG1/PPP1R12A/GNAI3/CAMK1D/PLCB2/CALM2/CAMK2D/PPP3CB/ADCY3/PRKCB/ITPR1/PIK3R5/PRKAA1/TRPM2/CCND1/MYL6/CACNA2D4/PPP1R12C/ITPR2/KCNJ2/PIK3CG/KCNJ5/SRC/PLA2G4C	1.74806578445656
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	13/1634	47/9376	1.58712466470481	AKR1A1/MDH1/ME2/ALDH2/GRHPR/ACAT1/PCK2/DLD/ACYP2/ME3/ALDH3A2/DLAT/PC	1.85373132309968
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	11/1634	38/9376	1.66101913289957	CD4/PTPRC/BTK/ORAI1/TAP1/CD40/IKBKG/BLNK/IL2RG/CIITA/RFX5	1.87570257423091
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/1634	85/9376	1.41763985888113	NME4/NME3/CMPK1/UPP1/IMPDH1/DCTD/DCK/HDDC2/ITPA/LACC1/AK3/ENTPD1/TK2/RRM2B/AMPD3/ENTPD6/NT5C2/AMPD2/GUK1/UCKL1/NME7	1.77690927377163
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	22/1634	90/9376	1.40263837889297	CD4/PTPN6/MAPK1/NFKBIE/IFNGR1/PIK3R1/STAT1/NFKB1/JAK1/MAPK13/HIF1A/CSNK2A1/IKBKG/IFNGR2/MAP2K3/PPP3CB/MAPK14/AKT2/LAT/PIK3CA/IKBKB/MTOR	1.76322268502292
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	38/1634	170/9376	1.28262653898769	MGST1/MGST2/TGFBR1/MAPK1/PIK3R1/ACTB/GADD45B/PBRM1/CDK6/GADD45G/ACTG1/TGFBR2/BCL2L1/SMAD2/BAX/BAK1/NFE2L2/APC/GSTO1/SMARCC2/RB1/PRKCB/ARID1A/AKT2/POLK/CCND1/GSK3B/E2F3/PLCG2/SOS1/SOS2/HGF/GSTT1/ARAF/DDB2/PIK3CA/SMAD4/MTOR	1.70838990483388
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	18/1634	71/9376	1.45472098195045	MAPK1/PIK3R1/STAT1/STAT5A/NFKB1/MAPK13/MAPK14/AKT2/CCND1/GSK3B/SOCS6/FOXO3/SOS1/SOS2/PIK3CA/SRC/GALT/TNFRSF11A	1.76685561300555
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/1634	30/9376	1.72141982864137	GPAA1/PIGT/PIGF/PIGH/B3GALT4/PIGK/MPPE1/PIGV/PIGU	1.8181130948431
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/1634	72/9376	1.43451652386781	TRADD/NFKB1/MAPK13/ATG5/IKBKG/ZNFX1/IFIH1/TRAF3/CYLD/MAPK14/MAP3K7/OTUD5/RNF125/CASP8/IKBKB/IKBKE/CASP10/DHX58	1.70028911557012
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	37/1634	168/9376	1.26374074721688	CSH1/IL10RB/IFNAR1/PTPN6/IL13RA1/IFNGR1/PIK3R1/CSH2/IL6R/STAT1/STAT5A/JAK1/IL10RA/OSM/BCL2L1/PIAS1/IFNGR2/CSF3R/IL4R/IL2RG/STAM/IL27RA/EP300/AKT2/CCND1/STAT6/SOCS6/STAM2/SOS1/SOS2/PIAS2/CREBBP/CSF2RB/PIK3CA/BCL2/MTOR/IL15	1.5846534432204
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/1634	22/9376	1.82574830310448	HNMT/ALDH2/AOC1/ALDH3B1/CNDP2/ALDH3A2/AMDHD1	1.78133429140992
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	23/1634	98/9376	1.34668898159019	ATP1B1/CAMK1/CREB3L2/ATP1B3/CALM3/ATP2B1/PRKACB/ADCY7/PRKACA/ORAI1/NR4A2/CAMK1D/PLCB2/CALM2/CAMK2D/ADCY3/PRKCB/SCARB1/ITPR1/CREB1/ITPR2/POMC/KCNJ5	1.58493324008998
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1634	59/9376	1.4588303632554	NME4/NME3/CMPK1/UPP1/DPYD/DCTD/DCK/HDDC2/ENTPD1/TK2/RRM2B/ENTPD6/NT5C2/UCKL1/NME7	1.62414645543449
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/1634	59/9376	1.4588303632554	MGLL/GNAI2/PIK3R1/PRKACB/PTGS1/ADCY7/PRKACA/FABP4/GNAI3/IRS2/ADCY3/ABHD5/PNPLA2/AKT2/PIK3CA	1.62414645543449
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1634	18/9376	1.91268869849041	ACSL1/CBR4/ACSF3/ACSL6/MCAT/OXSM	1.78054307975748
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	33/1634	149/9376	1.2708468533594	MRAS/GNA13/RRAS/RHOA/MAPK1/PIK3R1/AGPAT2/ADCY7/DGKZ/GNA12/SYK/FCER1G/PLCB2/SPHK1/CYTH4/CYTH1/LPAR6/AGPAT4/ADCY3/PIK3R5/AKT2/PLCG2/SOS1/SOS2/DGKH/ARF1/PIK3CA/PLD1/PIK3CG/PLD2/MTOR/PLA2G4C/DGKQ	1.53098786759619
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/1634	65/9376	1.41244703888523	LPL/MGLL/AKR1A1/ALDH2/GLA/AGPAT2/DGKZ/LPIN2/AGPAT4/ALDH3A2/GK/PNPLA2/MBOAT1/DGKH/DGKQ/GLYCTK	1.53289280510956
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/1634	32/9376	1.61383108935129	GALM/GLB1/GAA/GLA/HK3/GALE/G6PC3/GALT/GANC	1.59787402124159
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	26/1634	115/9376	1.29730189984567	GNAI2/GNB4/MAPK1/CREB3L2/PIK3R1/PRKACB/ADCY7/PRKACA/GNB2/GNAI3/PLCB2/CAMK2D/GNB1/ADCY3/PRKCB/ITPR1/PIK3R5/AKT2/CREB1/ITPR2/PIK3CA/KCNJ2/BCL2/GNGT2/PIK3CG/KCNQ1	1.473678485984
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	18/1634	75/9376	1.3771358629131	GPX1/ATP1B1/CREB3L2/ATP1B3/ASGR1/PRKACB/CANX/ADCY7/PRKACA/PLCB2/ADCY3/PRKCB/ITPR1/CREB1/ITPR2/HSP90B1/TTF2/HSPA5	1.50642919201211
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1634	110/9376	1.30410593078892	TFRC/CYBB/MAPK1/IFNGR1/EIF4EBP1/PIK3R1/SERPINE1/IL6R/NFKB1/HK3/HIF1A/CUL2/CAMK2D/IFNGR2/PGK1/PRKCB/EP300/AKT2/PLCG2/PFKFB3/CREBBP/PIK3CA/BCL2/MTOR/VEGFA	1.47387334752675
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1634	37/9376	1.55082867445169	MAPK1/GADD45B/GADD45G/BAX/BAK1/POLK/CCND1/DDB2/RXRB/TPM3	1.54224118048509
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	20/1634	86/9376	1.33443397569099	NCK1/MAPK1/EIF4EBP1/PIK3R1/HBEGF/STAT5A/CBL/CAMK2D/PAK2/PRKCB/AKT2/GSK3B/PLCG2/SOS1/SOS2/ARAF/PIK3CA/SRC/MTOR/MAP2K7	1.43132033403566
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	41/1634	195/9376	1.2064651790478	ITGB2/CYBA/NCF2/CYBB/ATG7/ITGAM/C5AR1/MAPK1/PIK3R1/SIGLEC9/ACTB/FPR3/FCGR1A/RAC2/ITGAL/C3/NCF4/NFKB1/SLC25A5/ACTG1/MAPK13/CASP1/SYK/CLEC7A/HDAC3/PLCB2/PRKCB/MAPK14/RAC1/FCGR3A/AKT2/PPIF/PLCG2/HDAC7/MAP3K7/PIK3CA/TLR7/SRC/TLR8/MTOR/HDAC10	1.33845634222388
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	28/1634	128/9376	1.25520195838433	PAPSS1/NME4/NME3/IMPDH1/ADCY7/DCK/HDDC2/ITPA/LACC1/PAPSS2/AK3/ENTPD1/PDE4A/ADCY3/NUDT9/RRM2B/AMPD3/PRPS1/ENTPD6/PRPS2/NT5C2/AMPD2/GUK1/PDE8A/ENPP4/PDE6G/FHIT/NME7	1.3355192672308
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1634	53/9376	1.40745017436087	ATP1B1/SLC8A1/ATP1B3/ATP2B1/PRKACB/PRKACA/AP2B1/CLTC/PLCB2/AP2A2/AP2S1/PRKCB/VDR	1.36653160821861
Human Diseases	Cancer: specific types	hsa05218	Melanoma	17/1634	73/9376	1.33626196743851	MAPK1/PIK3R1/MITF/GADD45B/CDK6/GADD45G/BAX/BAK1/RB1/AKT2/POLK/CCND1/E2F3/HGF/ARAF/DDB2/PIK3CA	1.32499045606994
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/1634	34/9376	1.51889984880121	BHLHE41/BHLHE40/FBXL3/PRKAA1/NR1D2/CREB1/DBP/PER1/PER3	1.39247738950166
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	35/1634	166/9376	1.20983321290056	ATP1B1/GNAI2/RGS2/GNA13/SLC8A1/RHOA/MAPK1/CREB3L2/ATP1B3/CALM3/GTF2I/ROCK1/ATP2B1/MEF2A/ATP2A2/ADCY7/SLC25A5/PPP1R12A/GNA12/GNAI3/PLCB2/CALM2/IRS2/PPP3CB/ADCY3/MEF2D/ITPR1/PIK3R5/AKT2/CREB1/PPIF/VASP/ITPR2/PIK3CG/KCNMB1	1.25309368165274
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	22/1634	99/9376	1.27512579899361	TRPV2/PTGER4/CALM3/PIK3R1/PRKCD/PRKACB/ADCY7/PRKACA/MAPK13/PLCB2/CALM2/CAMK2D/MAP2K3/ADCY3/PRKCB/MAPK14/ITPR1/PLCG2/ITPR2/PIK3CA/SRC/PLA2G4C	1.26424200717723
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1634	44/9376	1.43451652386781	CREB3L2/STX4/ARHGDIB/RAB5C/PRKACB/DYNC1H1/PRKACA/RAB11B/ARHGDIA/ADCY3/CREB1	1.32718159540759
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1634	16/9376	1.79314565483476	HEXB/HEXA/GLA/NAGA/GBGT1	1.45868023084956
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/1634	79/9376	1.30740746479091	ATP6V0D1/TCIRG1/ATP6V0B/ATP6V0E1/ATP6V1D/ATP6V0A1/ATP6V1B2/SLC1A3/ATP6V1H/ATP6V1A/AP2B1/CLTC/AP2A2/AP2S1/ATP6V1F/NAPA/ATP6V0E2/ATP6V1G1	1.26049643075772
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/1634	59/9376	1.36157500570504	GPX1/MGST1/MGST2/GSTK1/LAP3/ANPEP/GCLC/TXNDC12/ODC1/GSS/GSTO1/RRM2B/GSTT1/SMS	1.27988644806112
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1634	30/9376	1.53015095879233	ABCC3/NFKB1/IKBKG/MTHFR/ABCC5/MTR/IKBKB/SLC46A1	1.33607971690935
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	35/1634	168/9376	1.19543043655651	FTL/CHMP1B/CYBB/IFNAR1/IFNGR1/PYCARD/BID/TNFRSF1A/TRADD/XIAP/AIFM1/STAT1/STAT5A/CHMP3/SLC25A5/JAK1/GLUD1/SMPD1/CASP1/SHARPIN/BAX/CFLAR/CAMK2D/IFNGR2/BIRC2/CYLD/STAT6/FTH1/MLKL/CASP8/BCL2/PPIA/HSP90AA1/TNFRSF10A/PLA2G4C	1.17421944643492
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	48/1634	238/9376	1.15725702765806	CSF1R/MRAS/VEGFB/RRAS/GNB4/RHOA/RAP1A/MAPK1/STK4/CALM3/PIK3R1/RAB5C/RAC2/PRKACB/RASGRP3/NFKB1/PRKACA/REL/GNB2/RAP1B/BCL2L1/IKBKG/SHOC2/CALM2/GNB1/PAK2/PRKCB/RASAL2/RAC1/AKT2/PLCG2/SOS1/SOS2/HGF/CSF1/RASA3/RASSF1/LAT/PIK3CA/IKBKB/RASSF5/PLA2G12A/PLD1/GNGT2/PLD2/RALGAPA1/PLA2G4C/VEGFA	1.12890668608621
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	15/1634	65/9376	1.3241690989549	NCEH1/CREB3L2/PRKACB/ADCY7/PRKACA/ORAI1/PLCB2/ADCY3/SCARB1/ITPR1/CREB1/ITPR2/POMC/SP1/PDE8A	1.20480069579332
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	7/1634	26/9376	1.54486394878072	LMBRD1/SCARB1/ABCD4/TCN2/SLC19A2/BTD/SLC46A1	1.27806818149155
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	32/1634	154/9376	1.19232542243558	ATP1B1/GNAI2/SLC8A1/MAPK1/CREB3L2/ATP1B3/CALM3/PPP2R5C/ATP2B1/PRKACB/ATP2A2/ADCY7/PRKACA/MAPK13/PPP2CB/PPP2R3C/GNAI3/PLCB2/CALM2/CAMK2D/ADCY3/MAPK14/PIK3R5/PPP2R5A/AKT2/CACNA2D4/CREB1/SLC9A1/BCL2/PIK3CG/TPM3/KCNQ1	1.10552756918823
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1634	31/9376	1.48079125044419	FBP1/RPE/DERA/PRPS1/IDNK/PRPS2/RBKS/GLYCTK	1.23177909868609
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/1634	17/9376	1.68766649866801	CYP27A1/HSD3B7/SCP2/HSD17B4/ACOX2	1.30368504917836
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/1634	17/9376	1.68766649866801	PAPSS1/SEPHS2/PAPSS2/MTR/SEPSECS	1.30368504917836
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	23/1634	107/9376	1.23341607659662	FBP1/PCK2/CREB3L2/CALM3/SIK1/PRKACB/PGAM1/PRKACA/G6PC3/CPT1A/PLCB2/CALM2/CAMK2D/PPP3CB/ITPR1/EP300/AKT2/PRKAA1/CREB1/ITPR2/CREBBP/CRTC2/SIK2	1.11555578697106
Organismal Systems	Digestive system	hsa04978	Mineral absorption	14/1634	61/9376	1.3169332022393	ATP1B1/FTL/SLC31A1/SLC8A1/ATP1B3/ATP2B1/ATOX1/SLC30A1/SLC11A2/ATP7A/FTH1/CYBRD1/SLC46A1/VDR	1.14084411747624
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/1634	56/9376	1.33205105787725	ARRB2/PRKACB/PRKACA/SMURF2/ARRB1/CSNK1G2/SPOPL/CSNK1G1/CCND1/GSK3B/BCL2/IQCE/MGRN1	1.14492227886889
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	21/1634	97/9376	1.24226173200924	GNAI2/GNB4/MAPK1/CALM3/PRKACB/ADCY7/PRKACA/GNB2/GNAI3/PLCB2/CALM2/CAMK2D/GNB1/ADCY3/PRKCB/ITPR1/CREB1/GNGT2/KCNJ5/PER1/PER3	1.10180611505311
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	18/1634	82/9376	1.25957548437173	MGST1/MGST2/GUSB/NME4/NME3/CMPK1/UPP1/DPYD/TPMT/IMPDH1/ITPA/TK2/GSTO1/RRM2B/GSTT1/CES2/UCKL1/NME7	1.08456190536235
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/1634	67/9376	1.2846416631652	FBP1/GALM/AKR1A1/ALDH2/PCK2/ADPGK/DLD/ALDH3B1/PGAM1/HK3/G6PC3/PGK1/ALDH3A2/DLAT/MINPP1	1.07416113633491
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	20/1634	94/9376	1.22086512669601	MMP9/MAPK1/IL17RA/TRADD/NFKB1/MAPK13/IKBKG/TAB2/TRAF3/MAPK14/CASP3/MAPK6/GSK3B/MAP3K7/CEBPB/HSP90B1/CASP8/IKBKB/IKBKE/HSP90AA1	0.988679147217599
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	23/1634	110/9376	1.1997774563258	GNAI2/RPS6KA1/MAPK1/PIK3R1/CPEB4/RPS6KA3/PRKACB/ADCY7/PRKACA/MAPK13/STK10/GNAI3/CDC26/CDC27/ADCY3/MAPK14/AKT2/RPS6KA2/ANAPC7/ARAF/ANAPC10/PIK3CA/HSP90AA1	0.968237178247173
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1634	23/9376	1.49688680751424	ACAT1/ZMPSTE24/GGPS1/PCYOX1/PDSS1/ICMT	1.09605159374484
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1634	23/9376	1.49688680751424	ATP6AP2/PRCP/CTSA/ANPEP/NLN/PREP	1.09605159374484
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/1634	23/9376	1.49688680751424	ATP1B1/MDH1/PCK2/ATP1B3/GLUD1/GLS	1.09605159374484
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1634	33/9376	1.39104632617485	ACO2/BCAT1/IDH3G/DLD/OGDH/GOT2/DLAT/DLST	1.03377752581264
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1634	69/9376	1.24740567292853	GNAI2/CTSB/PTGER4/CALM3/PRKACB/PRKACA/ORAI1/GNAI3/PLCB2/CALM2/PPP3CB/ITPR1/CREB1/ITPR2/KCNJ2	0.947576808119868
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/1634	149/9376	1.15531532123582	MGLL/GNAI2/GNB4/NDUFS2/NDUFB9/MAPK1/NDUFB5/PRKACB/NDUFS1/ADCY7/PRKACA/NDUFS7/NDUFA9/GNB2/MAPK13/NDUFA10/NDUFS3/GNAI3/PLCB2/GNB1/ADCY3/PRKCB/MAPK14/ITPR1/NDUFB7/NDUFB3/ITPR2/ABHD6/GNGT2/KCNJ5	0.877934779431658
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/1634	50/9376	1.26237454100367	ITGB2/CD81/CD36/IL18/LRP1/SDC2/ITGAL/GYPC/CD40/HGF/THBS3	0.85456296853103
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/1634	93/9376	1.17229307326832	LYZ/ATP1B1/ATP1B3/CALM3/ATP2B1/PRKACB/BST1/KCNN4/ADCY7/PRKACA/SLC4A2/PLCB2/CALM2/ADCY3/CST3/PRKCB/ITPR1/ITPR2/SLC9A1	0.767096846934651
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	68/1634	362/9376	1.07786876931504	CSF1R/CSH1/FN1/VEGFB/ITGB5/GNB4/PCK2/ITGA6/IFNAR1/MAPK1/SPP1/CREB3L2/EIF4EBP1/YWHAH/PIK3R1/SGK3/CSH2/PPP2R5C/ITGAV/IL6R/CDK6/SGK1/NFKB1/JAK1/GNB2/SYK/OSM/BCL2L1/PDPK1/PPP2CB/PPP2R3C/IKBKG/G6PC3/YWHAG/LPAR6/GNB1/CSF3R/IL4R/IL2RG/ITGA4/PIK3R5/PPP2R5A/RAC1/AKT2/PRKAA1/CCND1/CREB1/GSK3B/FOXO3/SOS1/SOS2/HGF/CSF1/THBS3/HSP90B1/DDIT4/ITGB7/PIK3CA/ITGB1/IKBKB/RBL2/BCL2/GNGT2/PIK3CG/CRTC2/MTOR/HSP90AA1/VEGFA	0.694134931193261
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/1634	88/9376	1.17369533771003	ITGB2/A2M/C1QB/C1QA/C1QC/ITGAX/ITGAM/C5AR1/C2/SERPINE1/PLAUR/C3AR1/CD46/C3/CD59/SERPINA1/CFD/PLAU	0.752061704883498
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	17/1634	83/9376	1.17526654967483	DNASE2/IL18/SAMHD1/POLR3GL/PYCARD/NFKB1/CASP1/IKBKG/TREX1/CASP3/POLR3H/MLKL/CASP8/IKBKB/IKBKE/DNASE2B/CCL5	0.736792498573384
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	58/1634	308/9376	1.08054491408225	GPX1/SDHD/NDUFS2/NDUFB9/WIPI2/UQCRC2/SLC1A3/TUBA1A/CREB3L2/SDHB/NDUFB5/ACTR1A/PSMD9/NDUFS1/ACTR10/COX7A2L/NDUFS7/SLC25A5/NDUFA9/AP2B1/REST/SDHA/CLTC/BECN1/SDHC/CYC1/NDUFA10/NDUFS3/PLCB2/AP2A2/BAX/AP2S1/POLR2B/CASP3/ITPR1/EP300/UQCRB/COX8A/ACTR1B/KIF5B/CREB1/PPIF/NDUFB7/NDUFB3/CREBBP/SP1/CYCS/CASP8/MAP3K5/COX6A1/ERN1/ATG2A/PIK3C3/ATG13/MTOR/ULK2/DNAL4/MAP2K7	0.660302293739198
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	27/1634	138/9376	1.12266510563568	FBP1/RHOQ/PCK2/MAPK1/PRKAR2A/EIF4EBP1/CALM3/PIK3R1/PRKACB/PRKACA/HK3/PDPK1/G6PC3/CBL/CALM2/IRS2/AKT2/PRKAA1/GSK3B/SOS1/SOS2/ARAF/PRKAR1B/PIK3CA/IKBKB/SREBF1/MTOR	0.666893803613655
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/1634	144/9376	1.11573507411941	WIPI2/PIK3R1/PSMD9/ATP2A2/SLC25A5/BECN1/PLCB2/ATXN10/PRKCB/ITPR1/AKT2/OMA1/PPIF/ATXN2L/ITPR2/SP1/CYCS/KAT5/MAP3K5/PIK3CA/OPA1/ERN1/ATG2A/PIK3C3/MCU/ATG13/MTOR/ULK2	0.64295921200759
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1634	21/9376	1.36620621320744	ALDH2/BCAT1/PPCS/DPYD/ALDH3A2	0.771788922253685
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1634	37/9376	1.24066293956135	NANS/HK3/GALE/NAGK/UAP1L1/PMM2/MPI/GALT	0.673821667649331
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	20/1634	102/9376	1.12511099911201	ATP1B1/RHOA/RAP1A/ATP1B3/ATP2B1/BST1/ATP2A2/ADCY7/RAP1B/SLC4A2/PLCB2/ADCY3/PRKCB/ITPR1/RAC1/ITPR2/SLC9A1/TPCN2/PLA2G12A/KCNQ1	0.583642774337587
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1634	48/9376	1.19543043655651	CD81/CD9/LAMP1/LAMP2/CHMP1B/TGOLN2/CD63/PDCD6IP/IST1/SCARB1	0.623596448234335
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	10/1634	48/9376	1.19543043655651	ATP1B1/ATP1B3/PIK3R1/HK3/G6PC3/PLCB2/PRKCB/AKT2/SLC37A4/PIK3CA	0.623596448234335
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	15/1634	75/9376	1.14761321909425	SDS/ACO2/SDSL/BCAT1/IDH3G/PGAM1/ASL/MAT2B/RPE/PGK1/GOT2/MTR/PRPS1/PRPS2/PC	0.589625342582955
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	21/1634	108/9376	1.11573507411941	KPNA3/TMEM33/RANBP2/NUP214/IPO7/KPNA4/SUMO3/UPF3A/POM121/KPNB1/PHAX/THOC2/SNUPN/NUP210/NUP85/DDX19B/KPNA1/NMD3/NUP160/NUP107/AAAS	0.555736523704642
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1634	27/9376	1.27512579899361	ACAT1/HADHA/HMGCL/HADH/ECHS1/ACADS	0.657681612190567
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	9/1634	43/9376	1.20099057812189	CD36/ACAT1/SLC27A1/AGPAT2/ABCA1/SCARB1/GOT2/PLA2G12A/SLC27A4	0.60685421823929
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1634	38/9376	1.20801391483605	ATP1B1/MAPK1/ATP1B3/PIK3R1/SGK1/PDPK1/PRKCB/PIK3CA	0.590258611460053
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	13/1634	65/9376	1.14761321909425	ARRB2/MAPK1/SPP1/PIK3R1/KCNN4/PLCB2/ARRB1/PRKCB/ITPR1/AKT2/ITPR2/PIK3CA/KCNJ5	0.548616477160838
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1634	17/9376	1.35013319893441	LAMP1/LAMP2/TFRC/NRP2	0.663786032264097
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	32/1634	170/9376	1.08010655914753	ARPC1B/ARPC4/MSN/RAB13/RHOA/RAP1A/TUBA1A/WAS/ROCK1/ACTB/ACTR3/ARPC2/PRKACB/PRKACA/ACTG1/PPP2CB/HCLS1/YBX3/ACTR2/MYL12A/RAC1/ARPC3/PRKAA1/CCND1/MYL6/VASP/NF2/MAP3K5/ITGB1/SRC/ARPC5/MAP2K7	0.484219342772245
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/1634	60/9376	1.14761321909425	GNAI2/GNA13/MAPK1/GNA12/PPP2CB/GNAI3/PLCB2/PRKCB/ITPR1/ARAF/ITPR2/PLA2G4C	0.526952194332231
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1634	12/9376	1.43451652386781	VKORC1/COQ2/COQ7	0.691912693189277
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	26/1634	138/9376	1.08108491653806	RPS6KA1/MAPK1/YWHAH/CALM3/CPEB4/RPS6KA3/PPP2R5C/PRKACB/ADCY7/PRKACA/MAPK13/PPP2CB/CDC26/YWHAG/CALM2/CAMK2D/CDC27/PPP3CB/ADCY3/MAPK14/ITPR1/PPP2R5A/RPS6KA2/ANAPC7/ITPR2/ANAPC10	0.440834645888361
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	22/1634	116/9376	1.08825391465834	GNAI2/GNB4/SLC1A3/MAPK1/HOMER3/PRKACB/ADCY7/PRKACA/GNB2/GLS/GNAI3/PLCB2/GNB1/PPP3CB/ADCY3/PRKCB/ITPR1/ITPR2/PLD1/GNGT2/PLD2/PLA2G4C	0.439382302601886
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	29/1634	155/9376	1.07357365657204	NCEH1/GNAI2/RAP1A/MAPK1/CREB3L2/AHR/PRKACB/CDK6/ADCY7/PRKACA/ORAI1/KMT2A/RAP1B/GNAI3/PLCB2/CAMK2D/APC/RB1/ADCY3/SCARB1/ITPR1/CCND1/CREB1/GSK3B/E2F3/ITPR2/POMC/SP1/PDE8A	0.42431096965268
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/1634	83/9376	1.10613322322337	DCAF7/MAX/PCGF5/MTF2/ASXL2/USP7/KDM2A/EP300/FBRS/KDM2B/JARID2/SFMBT2/CREBBP/L3MBTL2/MBD6/BMI1	0.446167068761687
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	34/1634	184/9376	1.06029482198925	GNAI2/CXCR4/PLXNC1/RRAS/CFL1/NCK1/DPYSL2/LIMK1/RHOA/MAPK1/PIK3R1/ROCK1/RAC2/CDK5/NRP1/ILK/PDPK1/GNAI3/PLXNB2/CAMK2D/MYL12A/PPP3CB/PAK2/RAC1/SSH1/GSK3B/PLCG2/SEMA4A/EPHB6/PIK3CA/ITGB1/PLXNA1/SRC/EPHB2	0.379462620706161
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	9/1634	45/9376	1.14761321909425	ABCC3/ABCD1/TAP1/ABCA1/ABCC5/ABCB8/ABCD4/ABCB7/ABCG1	0.455987034612961
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/1634	134/9376	1.07053471930434	GNA13/RHOA/MAPK1/CALM3/ROCK1/PRKCD/PRKACB/ADCY7/PRKACA/PPP1R12A/GNA12/ARHGEF1/PLCB2/CALM2/ADCY3/PRKCB/ITPR1/MYL6/PPP1R12C/ARAF/ITPR2/PLA2G12A/KCNMB1/PLA2G4C/ARHGEF11	0.377796073827908
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1634	29/9376	1.18718608871819	RASSF4/RASSF2/MOB1A/RASSF1/NF2/MOB1B	0.463790157814063
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	19/1634	101/9376	1.07943817637578	GNAI2/MAPK1/CREB3L2/CALM3/MITF/PRKACB/ADCY7/PRKACA/GNAI3/PLCB2/CALM2/CAMK2D/ADCY3/PRKCB/EP300/CREB1/GSK3B/POMC/CREBBP	0.368738151540411
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1634	46/9376	1.12266510563568	FTL/GUSB/ALAS1/BLVRA/UROS/FECH/FTH1/FXN/BLVRB	0.383128281792921
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1634	24/9376	1.19543043655651	HS3ST1/B3GAT3/B4GALT7/B3GALT6/HS2ST1	0.440383110620497
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1634	35/9376	1.14761321909425	FBP1/HSD17B14/HK3/SORD/PMM2/PFKFB3/MPI	0.401927450437669
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1634	52/9376	1.10347424912908	ALOX5/PRKACB/ADCY7/PRKACA/ACOT2/ADCY3/ACOT4/SCARB1/CYP1B1/PLA2G4C	0.34373036860512
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1634	41/9376	1.11962265277488	SDS/GRHPR/SDSL/ALAS1/DLD/PGAM1/GATM/GLYCTK	0.352641383922245
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1634	19/9376	1.20801391483605	DLD/OGDH/DLAT/DLST	0.416951896996194
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7/1634	36/9376	1.11573507411941	AKR1A1/GUSB/CRYL1/RPE/SORD/FGGY/DHDH	0.319615540174906
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1634	110/9376	1.04328474463113	ID2/TGFBR1/HAMP/TFRC/TGIF1/RHOA/MAPK1/ROCK1/TGFBR2/SMURF2/PPP2CB/SMAD7/SMAD2/SKIL/EP300/TMEM53/CREBBP/SP1/SMAD4/LEMD3	0.20978292432781
NA	NA	hsa04981	Folate transport and metabolism	6/1634	31/9376	1.11059343783314	ABCC3/SLCO2B1/MTHFR/ABCC5/MTR/SLC46A1	0.283338527997022
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1634	20/9376	1.14761321909425	LIPA/SOAT1/LBR/LSS	0.303584939803467
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1634	20/9376	1.14761321909425	CYB5R3/NANS/NPL/UAP1L1	0.303584939803467
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	40/1634	226/9376	1.01558691955243	ATP1B1/GNAI2/RRAS/RHOA/RAP1A/MAPK1/CREB3L2/ATP1B3/CALM3/PIK3R1/ROCK1/RAC2/ATP2B1/PRKACB/ATP2A2/NFKB1/ADCY7/PRKACA/ORAI1/PPP1R12A/VAV1/ACOX1/RAP1B/SUCNR1/GNAI3/PDE4A/CALM2/CAMK2D/ADCY3/EP300/RAC1/AKT2/CREB1/SLC9A1/POMC/CREBBP/PIK3CA/PLD1/PLD2/HCAR2	0.108965507844686
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1634	89/9376	1.03156244412966	GNAI2/MAP3K2/MAPK1/TUBA1A/PRKACB/ADCY7/PRKACA/GNAI3/PLCB2/ADCY3/PRKCB/ITPR1/SOS1/SOS2/ITPR2/SRC	0.137439949860144
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/1634	89/9376	1.03156244412966	GNAI2/GABARAP/GNB4/GABARAPL2/PRKACB/ADCY7/PRKACA/GNB2/GABARAPL1/GLS/GNAI3/GNB1/ADCY3/PRKCB/GNGT2/SRC	0.137439949860144
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/1634	49/9376	1.05393050733145	COLGALT1/LFNG/PLOD3/GALNT7/GALNT6/RFNG/GALNT1/MFNG/GALNT11	0.173878801563719
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1634	38/9376	1.05701217548154	BST1/SIRT2/NNT/NADK/NADSYN1/NT5C2/SIRT6	0.161777290536434
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1634	91/9376	1.00889074206088	ARRB2/GNAI2/GNB4/PRKACB/ADCY7/PRKACA/GNB2/GNAI3/PDE4A/ARRB1/GNB1/ADCY3/PRKCB/GNGT2/KCNJ5/PDE8A	0.0391518991712855
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/1634	115/9376	0.997924538342824	GNAI2/GNB4/ALOX5/MAPK1/DUSP1/PRKACB/PTGS1/PRKACA/GNB2/GNAI3/PLCB2/GNB1/PRKCB/CASP3/ITPR1/ARAF/ITPR2/GNGT2/KCNJ5/PLA2G4C	-0.0102877351078252
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1634	16/9376	1.07588739290086	ALDH3B1/IL4I1/GOT2	0.139565083815853
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	26/1634	150/9376	0.994598123215014	TGFBR1/MAPK1/PIK3R1/GADD45B/GADD45G/TGFBR2/SMAD2/BAX/BAK1/APC/RB1/AKT2/POLK/CCND1/GSK3B/E2F3/SOS1/SOS2/HGF/ARAF/DDB2/PIK3CA/RXRB/BCL2/SMAD4/MTOR	-0.0306385818187579
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/1634	87/9376	0.989321740598489	ATP1B1/SLC8A1/UQCRC2/ATP1B3/ATP2A2/COX7A2L/CYC1/UQCRB/COX8A/CACNA2D4/SLC9A1/COX6A1/SLC9A6/TPM3/SLC9A7	-0.0459685380962954
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/1634	105/9376	0.983668473509355	SLC8A1/ITGB5/ITGA6/ACTB/PRKACB/ITGAV/ATP2A2/ADCY7/PRKACA/ACTG1/SNTB1/LMNA/ADCY3/ITGA4/CACNA2D4/ITGB7/ITGB1/TPM3	-0.0773113433351541
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	27/1634	158/9376	0.980555598593186	YWHAH/ATRX/GADD45B/PPP2R5C/CDK6/GADD45G/NIPBL/PPP2CB/ATM/CDC26/YWHAG/SMAD2/CCNH/ESCO1/RB1/CDC27/PPP2R5A/EP300/CCND1/GSK3B/E2F3/ANAPC7/ANAPC10/CREBBP/MAD2L1BP/RBL2/SMAD4	-0.113237389894627
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1634	23/9376	0.997924538342824	GLUD1/ASL/GLS/GOT2	-0.0045781313222714
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1634	47/9376	0.976692101356806	MAPK1/PIK3R1/PRKCD/HK3/IRS2/PIK3CA/IKBKB/MTOR	-0.0735901323652346
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/1634	71/9376	0.969813987966969	MAPK1/PIK3R1/PGAM1/HK3/HIF1A/SLC16A3/GLS/AKT2/PIK3CA/SLC1A5/SIRT6/MTOR	-0.117290221722437
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	25/1634	148/9376	0.969267921532303	MAPK1/NOTCH2/PIK3R1/GADD45B/CDK6/GADD45G/BAX/BAK1/APC/RB1/AKT2/POLK/CCND1/GSK3B/E2F3/SOS1/SOS2/ARAF/SP1/NCOA1/DDB2/PIK3CA/HES1/NOTCH1/MTOR	-0.173122724831452
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1634	36/9376	0.956344349245206	GYG1/GAA/HK3/G6PC3/PGM2L1/GANC	-0.120560033367973
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1634	49/9376	0.936827117627957	GNAI2/CREB3L2/PRKACB/NFKB1/PRKACA/CDK5/GNAI3/CREB1	-0.203677391919705
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1634	37/9376	0.930497204671011	GLUD1/ASL/IL4I1/GLS/ASRGL1/GOT2	-0.194597845186425
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1634	37/9376	0.930497204671011	ALDH3B1/FAH/IL4I1/COMT/FAHD1/GOT2	-0.194597845186425
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1634	12/9376	0.956344349245206	ASGR1/CD46	-0.0695161109589228
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1634	31/9376	0.925494531527619	AKR1A1/ALDH2/GUSB/HSD17B14/ALDH3A2	-0.190881757347512
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1634	26/9376	0.882779399303267	ACAA1/ACOX1/PLA2G12A/PLA2G4C	-0.274960236038877
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	38/1634	233/9376	0.935821938317197	VIM/ZYX/ATP1B1/TLN1/FMNL2/FN1/FMNL1/ITGB5/ITGA6/ATP1B3/SDC2/ACTB/CAPZA2/ITGAV/PDLIM7/ACTG1/SPTAN1/SUN2/SNTB1/CAPZA1/FMNL3/LMNA/FHL3/ITGA4/DIAPH2/LBR/AMPD3/MYOZ1/THBS3/ITGB7/SYNE1/DAAM1/ITGB1/SDC3/AMPD2/TPM3/TLN2/PDLIM4	-0.455727543774102
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1634	34/9376	0.843833249334005	POLR3GL/CRCP/POLR2B/POLR3H/POLR2M	-0.419076378219662
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1634	28/9376	0.819723727924462	PCBD1/CBR1/MOCS2/SPR	-0.438877496948626
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	12/1634	79/9376	0.871604976527276	MGST1/MGST2/GSTK1/ALDH3B1/CBR1/GSTO1/HSD11B1/CYP1B1/EPHX1/GSTT1/CYP2S1/DHDH	-0.526472149674371
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	13/1634	86/9376	0.86738208419914	ATP1B1/CREB3L2/ATP1B3/PRKACB/KCNN4/ADCY7/PRKACA/PLCB2/CAMK2D/ADCY3/PRKCB/CREB1/KCNMB1	-0.567582044112021
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1634	86/9376	0.86738208419914	SLC8A1/ITGB5/ITGA6/ACTB/ITGAV/ATP2A2/ACTG1/SNTB1/LMNA/ITGA4/CACNA2D4/ITGB7/ITGB1	-0.567582044112021
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	18/1634	117/9376	0.882779399303267	TFPT/ACTB/BAZ2B/PBRM1/MBD2/MEAF6/ACTG1/BAZ1A/CHD4/RSF1/EPC1/SMARCC2/CDK2AP1/ARID1A/BAZ2A/KAT5/INO80D/DPF2	-0.58613804604803
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/1634	99/9376	0.869403953859278	SLC8A1/ITGB5/ITGA6/ACTB/ITGAV/ATP2A2/ACTG1/SNTB1/LMNA/ITGA4/PRKAA1/CACNA2D4/ITGB7/ITGB1/TPM3	-0.600107325835306
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/1634	29/9376	0.791457392478791	CALM3/CALM2/GNB1/PDE6G	-0.5167051115579
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1634	36/9376	0.796953624371005	GALNT7/ST6GALNAC4/GALNT6/GALNT1/GALNT11	-0.560735606910851
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/1634	100/9376	0.860709914320685	CSF1R/IL18/CXCR4/TNFRSF14/IL10RB/TNFRSF1A/IL6R/IL10RA/TNFRSF1B/IL2RG/CSF1/CCL23/TNFRSF10A/CXCL9/CCL5	-0.643316834586297
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	15/1634	103/9376	0.835640693515228	ATP1B1/SLC7A7/PRCP/SLC8A1/ATP1B3/KCNN4/COL8A2/SLC7A8/KCNE3/SLC16A10/SLC3A2/SLC36A1/SLC1A5/COL22A1/KCNQ1	-0.770527003441008
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1634	103/9376	0.835640693515228	ITGB2/FN1/HSPB1/ITGAM/PIK3R1/RAB5C/PRKACB/NFKB1/PRKACA/PLCB2/RAB7A/PRKCB/CASP3/PIK3CA/PRDX1	-0.770527003441008
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	11/1634	78/9376	0.809214449361328	C1D/TOB1/HSPA9/EXOSC6/ZCCHC7/CNOT4/CNOT6L/MPHOSPH6/BTG1/DIS3L/PARN	-0.777290018976351
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	39/1634	254/9376	0.881041644580229	CXCR4/VEGFB/SLC8A1/MCOLN1/CAMK1/CALM3/PTAFR/ATP2B1/PRKACB/P2RX4/ORAI2/ATP2A2/P2RX7/ADCY7/PRKACA/ORAI1/SLC25A5/TFEB/CAMK1D/PLCB2/SPHK1/CALM2/CAMK2D/PPP3CB/ADCY3/PRKCB/ORAI3/TPCN1/ITPR1/ITPKB/PPIF/PLCG2/HGF/ITPR2/TPCN2/MCU/STIM1/STIM2/VEGFA	-0.882982012799867
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1634	39/9376	0.735649499419389	DLD/MAT2B/MTHFR/AHCYL1/MTR	-0.759965438578096
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	36/1634	238/9376	0.867942770743548	C1QB/C1QA/C1QC/CYBB/C5AR1/IFNAR1/MAPK1/C2/PIK3R1/TNFRSF1A/HBEGF/C3AR1/IL6R/STAT1/C3/NFKB1/JAK1/NRP1/MAPK13/CASP1/SYK/IKBKG/TAB2/IFIH1/TRAF3/PRKCB/CFD/MAPK14/IRAK4/PLCG2/MAP3K7/PIK3CA/IKBKB/IKBKE/TLR7/TLR8	-0.948003986046232
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/1634	69/9376	0.748443403757118	CREB3L2/CALM3/PRKACB/PRKACA/CALM2/CAMK2D/PPP3CB/PRKCB/CREB1	-0.963475063880967
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1634	63/9376	0.728643313710633	LTA4H/ALOX5/TBXAS1/PTGS1/CBR1/PTGES2/PLA2G12A/PLA2G4C	-0.992775569122181
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/1634	63/9376	0.728643313710633	GADD45B/GADD45G/BAX/BAK1/APC/POLK/GSK3B/DDB2	-0.992775569122181
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/1634	90/9376	0.765075479396165	NCEH1/ATP1B1/ABCC3/ATP1B3/PRKACB/ADCY7/PRKACA/SLC4A2/ADCY3/SCARB1/EPHX1/SLC9A1	-1.0287748652667
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1634	70/9376	0.737751355132016	MGST1/MGST2/GSTK1/CBR1/GSTO1/HSD11B1/CYP1B1/EPHX1/GSTT1	-1.01173279894031
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1634	28/9376	0.614792795943347	B3GNT2/ST3GAL6/FUT4	-0.937776067679752
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/1634	144/9376	0.796953624371005	ID2/KLF4/MAPK1/PIK3R1/JAK1/REST/PCGF5/MAPK13/SMAD2/SKIL/APC/MAPK14/AKT2/JARID2/GSK3B/KAT6A/PIK3CA/SMAD4/SETDB1/BMI1	-1.12801187253506
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	22/1634	157/9376	0.804060217199791	ITGB2/ID2/TGFBR1/YWHAH/SERPINE1/ACTB/ACTG1/TGFBR2/PPP2CB/YWHAG/SMAD7/SMAD2/MOB1A/APC/BIRC2/CCND1/GSK3B/RASSF1/NF2/TP53BP2/MOB1B/SMAD4	-1.13740628003152
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/1634	44/9376	0.652052965394459	GTF2I/TAF12/CCNH/GTF2A1/TAF13	-1.0627648780639
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/1634	44/9376	0.652052965394459	POLD4/MBD4/MPG/PARP4/PNKP	-1.0627648780639
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8/1634	66/9376	0.695523163087423	HSD17B11/SRD5A3/HSD17B12/COMT/DHRS9/HSD11B1/CYP1B1/SRD5A1	-1.14034553739714
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1634	13/9376	0.441389699651634	RAD50	-0.925887422925598
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	19/1634	143/9376	0.762400390307367	HLA-DMB/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-DRA/HLA-DPB1/C1QB/C1QA/C1QC/C2/HLA-DQA1/FCGR1A/C3/HLA-DOA/HLA-DQB1/CD86/CD40/HLA-DRB1/FCGR3A	-1.31530782751664
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1634	54/9376	0.637562899496804	ERCC1/REV3L/POLK/ERCC4/REV1/HES1	-1.22704378143093
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1634	23/9376	0.498962269171412	FUT4/POMGNT1	-1.10520785638938
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1634	14/9376	0.409861863962231	B3GNT2	-1.01512251620431
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/1634	178/9376	0.773671833097245	RHOA/RAC2/PRKACB/MMP7/PRKACA/TLE3/CTNNBIP1/CSNK2A1/CTBP1/PLCB2/CAMK2D/PSEN1/APC/PPP3CB/PRKCB/EP300/RAC1/CCND1/GSK3B/MAP3K7/CREBBP/CHD8/DAAM1/SMAD4	-1.40051248683216
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/1634	63/9376	0.637562899496804	POLD4/ERCC1/CCNH/POLR2B/POLR2M/DDB2/ERCC4	-1.325999014962
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1634	15/9376	0.382537739698082	NFS1	-1.09946144906716
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1634	89/9376	0.644726527581038	CD36/FN1/ITGB5/ITGA6/SPP1/ITGAV/ITGA4/THBS3/ITGB7/ITGB1	-1.54705282123621
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1634	17/9376	0.337533299733602	GLUD1	-1.25591101847871
NA	NA	hsa04081	Hormone signaling	29/1634	219/9376	0.759835236386602	CSH1/GNAI2/HAMP/GNA13/GNB4/RHOA/PIK3R1/APPL1/CSH2/PRKACB/ITGAV/STAT5A/ADCY7/PRKACA/GNB2/GNA12/GNAI3/PLCB2/SLC16A10/GNB1/IRS2/ADCY3/POMC/ADIPOR2/PIK3CA/GNGT2/THRA/SRC/SMAD4	-1.65211327274795
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1634	36/9376	0.478172174622603	POLD4/RNASEH2B/RNASEH1	-1.44108675399661
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7/1634	68/9376	0.590683274533804	ALDH1A1/DHRS3/DHRS4L2/DHRS4/PNPLA4/DHRS9/CYP2S1	-1.55621945729828
Cellular Processes	Cell motility	hsa04814	Motor proteins	25/1634	194/9376	0.739441507148355	MYO9B/TUBA1A/MYO1F/ACTB/MYO1E/CAPZA2/ACTR1A/ACTR10/HOOK3/DYNC1H1/ACTG1/KIF1B/MYO5A/CAPZA1/MYL12A/DYNLT3/MYL6/ACTR1B/KIF5B/KIF1C/MYO9A/KIF13B/KIF16B/TPM3/DNAL4	-1.68469984160557
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1634	37/9376	0.465248602335506	IL18/PLCB2/PRKCB	-1.49722711444006
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1634	46/9376	0.498962269171412	PSMB8/PSMD9/PSME4/PSMB9	-1.56492528116284
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	44/1634	323/9376	0.781656062540973	VIM/ST14/TIMP3/MARCKS/MMP9/RHOA/MAPK1/NOTCH2/PIK3R1/ROCK1/FOXP1/DICER1/CDK6/NFKB1/GLS/ATM/ZEB2/BAK1/APC/IRS2/PRKCB/PLAU/CASP3/EP300/CCND1/CYP1B1/E2F3/PLCG2/SOS1/SOS2/CREBBP/RASSF1/DDIT4/PIK3CA/IKBKB/BCL2/SPRY2/NOTCH1/MTOR/DNMT3A/BMF/MDM4/BMI1/VEGFA	-1.83455704088725
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	40/1634	298/9376	0.770210214157213	CD4/CSF1R/CSH1/TNFSF12/IL18/CXCL16/CXCR4/TGFBR1/TNFRSF14/TNFSF13B/IL10RB/IFNAR1/IL13RA1/IFNGR1/IL17RA/TNFRSF1A/CSH2/IL6R/IL10RA/TGFBR2/TNFRSF12A/OSM/CD40/TNFRSF1B/IFNGR2/CSF3R/TNFRSF21/IL4R/IL2RG/IL27RA/CSF1/CCL23/CSF2RB/IL16/TNFRSF11A/TNFRSF10A/CXCL9/CCL5/IL15/TNFSF9	-1.85194823824199
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1634	30/9376	0.382537739698082	PLA2G12A/PLA2G4C	-1.5561205506931
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1634	41/9376	0.419858494790578	POLD4/RAD50/ATM	-1.71022710600474
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1634	23/9376	0.249481134585706	POLD4	-1.65552271892293
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/1634	103/9376	0.557093795676819	PPP2R5C/PPP2CB/PPP2R3C/UPF3A/CPSF2/PPP2R5A/GSPT1/CPSF7/DDX19B/GSPT2	-2.07637278181258
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1634	73/9376	0.471621870860649	MGST1/MGST2/GSTK1/ALDH3B1/GSTO1/GSTT1	-2.08199572386596
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1634	26/9376	0.220694849825817	HES1	-1.8279886535693
NA	NA	hsa04519	Cadherin signaling	53/1634	404/9376	0.752766096683108	VIM/ARPC1B/ARPC4/NCKAP1L/CYFIP1/EVL/MRAS/RRAS/APH1B/RHOA/MAPK1/MYO1F/YWHAH/APH1A/ROCK1/ACTB/MYO1E/TMC6/ACTR3/ARPC2/TAOK3/RAC2/TAOK1/PSENEN/ADAM10/NFKB1/LHFPL2/ACTG1/VAV1/MAPK13/PSEN2/IKBKG/YWHAG/SHOC2/MOB1A/TMC8/PSEN1/APC/ACTR2/MAP2K3/MAPK14/EP300/RAC1/ARPC3/ARHGAP35/GSK3B/VASP/CREBBP/NF2/MOB1B/DAAM1/IKBKB/ARPC5	-2.33366845876356
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1634	191/9376	0.600844617326831	GNAI2/GNB4/SLC29A3/MAPK1/CREB3L2/CALM3/PRKACB/PRKACA/GNB2/HDAC3/GNAI3/CALM2/GNB1/CREB1/HDAC7/SOS1/SOS2/ARAF/GNGT2/HDAC10	-2.56037851534228
NA	NA	hsa04082	Neuroactive ligand signaling	18/1634	199/9376	0.51902105386172	GNAI2/GNB4/SLC1A3/P2RY11/PRKACB/P2RX4/OGFRL1/ADCY7/PRKACA/GNB2/SLC17A9/GNAI3/PLCB2/GNB1/ADCY3/PRKCB/POMC/GNGT2	-3.15055684264223
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1634	86/9376	0.200165096353648	PRKACB/PRKACA/PLCB2	-3.42315687003728
NA	NA	hsa04382	Cornified envelope formation	16/1634	217/9376	0.423083214412626	S100A4/ST14/ITGA6/UGCG/DST/PPP2R5C/SLC27A1/PPP2CB/ELOVL1/PPP2R3C/ABHD5/PPP2R5A/S100A6/PADI2/SPTLC2/SLC27A4	-3.95006364589727
Genetic Information Processing	Transcription	hsa03040	Spliceosome	15/1634	243/9376	0.354201610831558	HSPA1A/HSPA1B/PRPF38B/SF3B1/HSPA8/BCAS2/RBMX2/SF3A1/THOC2/CWC25/PRPF40A/DHX8/HSPA6/AQR/U2AF1L4	-4.68574279635535
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/1634	183/9376	0.188133314605614	CSNK2A1/GNL2/LSG1/RIOK2/NOP10/NMD3	-5.09526429737623
Genetic Information Processing	Translation	hsa03010	Ribosome	8/1634	222/9376	0.206777156593558	MRPL35/MRPL34/MRPL44/MRPS7/MRPS18B/MRPS23/MRPL39/MRPL45	-5.49479287720369
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	20/1634	370/9376	0.310165734890337	TSPO/CSH1/PTGER4/C5AR1/NR3C1/P2RY11/FPR3/PTAFR/CSH2/P2RX4/C3AR1/OGFRL1/C3/P2RX7/LPAR6/PGRMC1/GPR35/POMC/UTS2/THRA	-6.21963264186317
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	11/1634	449/9376	0.140576229510431	ARRB2/RGS2/SLC8A1/CALM3/PRKACB/PRKACA/CALM2/CAMK2D/ARRB1/GNB1/ADCY3	-8.57359265073834