category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	56/1682	112/9376	2.7871581450654	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/NFKBIA/HLA-DRB1/LY96/TGFB2/LAMB2/LAMA2/MAPK3/IL10/BIRC3/SOCS1/TNFRSF1A/LAMC3/IFNGR2/ITGB1/HSPA1B/HSPA1A/HLA-DOA/ALOX5/LAMA5/GNAI2/MAPK1/AKT3/PIK3R5/MAP2K3/IFNGR1/NFKB1/PDPK1/BIRC7/CD40/LAMC1/XIAP/LAMA3/TLR4/MAPK8/TLR2/STAT3/PPIF/BCL2/CIITA/STAT1/MAPK14/TGFB3/HLA-DRB5/HSPA6/TAB2/LAMB3/JAK2/LAMB1	8.89601007065659
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	92/1682	250/9376	2.05134839476813	PSAP/CTSS/LAPTM5/CLTB/CTSB/CTSD/CTSA/LAPTM4A/HEXB/ATP6V0E1/IDS/CD68/LAMP2/NAGLU/LGMN/ATP6V0D1/CTSO/SLC15A3/GNPTG/ASAH1/HEXA/SLC11A1/GAA/ATP6V1G1/GNS/GALNS/VAMP8/DEPTOR/AGA/CTSZ/CTSC/BLOC1S6/TPP1/IGF2R/MCOLN1/PLA2G15/CTSF/DMXL2/CTSH/SLC17A5/CLCN7/LAMP1/LIPA/ACP2/SCARB2/ARSA/MANBA/MITF/CLTC/AP2A2/BLOC1S1/ATP6AP1/HGSNAT/AP1S2/GUSB/LAMTOR4/NAGA/NPC1/VPS13C/VAMP7/VPS35/CTSK/PLEKHM1/NEU1/RRAGC/ENTPD4/SLC29A3/ATP6V0A1/GLB1/GNPTAB/TFE3/TPCN1/AP2B1/SUMF1/SMPD1/TLR8/GGA1/CD63/SLC15A4/NPC2/ATP6V1B2/ATP6V1H/RRAGD/NAGPA/ARL8B/CTBS/SPG11/MFSD8/FUCA1/CTNS/GPR155/AP5S1	7.87769153089851
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	42/1682	78/9376	3.00155492545504	HLA-DRA/HLA-DPA1/HLA-DPB1/FCGR3A/HLA-DQA1/HLA-DQA2/HLA-DMB/ITGB2/HLA-DQB1/NCF2/HLA-DMA/FOS/NFKBIA/HLA-DRB1/TGFB2/MAPK3/IL10/JUN/FCGR1A/FCGR2A/IFNGR2/ITGB1/EEF1A1/HLA-DOA/C3/MAPK1/IFNGR1/NFKB1/ITGAM/TLR4/CYBB/IL1B/TLR2/STAT1/MAPK14/MARCKSL1/PRKCB/TGFB3/HLA-DRB5/PTGS2/TAB2/JAK2	8.29932144187076
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	52/1682	109/9376	2.65930685400735	IL6ST/HLA-DRA/EBI3/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/TGFBR1/HLA-DQB1/HLA-DMA/FOS/NFKBIA/HLA-DRB1/MAPK3/IL4R/CD4/SMAD3/IL1RAP/TGFBR2/IL2RB/IL6R/JUN/AHR/IL1R1/IFNGR2/HLA-DOA/STAT6/IL27RA/MAPK1/SMAD4/IFNGR1/NFKB1/CD3E/CD3D/MAPK8/IL1B/STAT3/JAK3/RXRB/STAT1/MAPK14/RARA/LAT/LCK/RXRA/IL2RG/HLA-DRB5/NFKBIE/STAT5A/JAK2/RUNX1	8.14690997909954
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	73/1682	181/9376	2.24820491259419	HLA-DRA/HLA-DPA1/HLA-DPB1/CTSS/FCGR3A/CD74/HLA-DQA1/HLA-DQA2/HLA-DMB/CTSD/LSP1/ITGB2/HLA-DQB1/HLA-DMA/FCER1G/HLA-DRB1/MRC2/TGFB2/LAMP2/PLK3/ITGAX/MAPK3/ATP6V0D1/IL10/CEBPB/SYK/CREBBP/TNFRSF1A/FCGR1A/FCGR2A/IFNGR2/SPHK1/RAB5A/VDR/HLA-DOA/C3/CAMK2D/CAMK2G/MAPK1/AKT3/IFNGR1/CORO1A/LAMP1/CD14/NFKB1/ITGAM/IL18/TLR4/MAPK8/IL1B/TLR2/ATP6AP1/BCL2/CIITA/STAT1/MAPK14/CARD9/BID/ATP6V0A1/EP300/TRADD/TGFB3/TLR1/HLA-DRB5/ARHGEF12/ATP6V1H/TLR6/CALM2/RAB5B/JAK2/CAMP/RAF1/BAX	7.92814986732219
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	79/1682	204/9376	2.158681308433	FN1/TIMP3/IGF2/CDKN1A/DCN/SDC2/HGF/CD44/WNT2/GPC3/MMP9/LUM/VTN/TGFB2/PIK3R1/FZD2/MAPK3/WNT2B/VEGFA/HSPG2/HBEGF/MRAS/ITGB1/SMO/VAV3/FZD1/PTK2/CAMK2D/CAMK2G/MAPK1/AKT3/FAS/PPP1R12B/COL1A2/ITPR2/PDPK1/PIK3CA/PRKCA/THBS1/WNT5B/TWIST1/FGF2/TLR4/TLR2/SOS1/STAT3/EGFR/ITPR1/WNT4/MAPK14/ESR1/ANK2/MAP2K1/HSPB2/DDX5/PRKACB/FRS2/ITGB5/FZD7/FGFR1/FLNA/PRKCB/PLAUR/ARHGEF1/ARHGEF12/CD63/ROCK2/WNT9A/PLCG2/PIK3CD/TIAM1/VAV1/PDCD4/MSN/RAF1/HCLS1/COL1A1/PRKACA/ITGA2	7.82293289187486
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	83/1682	224/9376	2.06548326821811	HLA-B/HLA-DRA/HLA-DPA1/CREB5/HLA-DPB1/HLA-A/CDKN1A/HLA-DQA1/HLA-DQA2/HLA-DMB/TGFBR1/ITGB2/HLA-DQB1/HLA-DMA/FOS/SPI1/CREB3L1/CCND2/NFKBIA/HLA-F/HLA-DRB1/ADCY7/TGFB2/PIK3R1/MAPK3/CD4/SMAD3/TGFBR2/IL2RB/JUN/CREBBP/TNFRSF1A/IL1R1/MSX1/ZFP36/ANAPC13/HLA-E/HLA-DOA/ICAM1/MAPK1/AKT3/SMAD4/ANAPC16/VAC14/NRP1/B2M/NFKB1/TSPO/IL15RA/PIK3CA/ADCY3/ATF4/CD40/XIAP/CD3E/CD3D/MAPK8/TLN2/CREB3L2/JAK3/ETS2/CDKN2A/NFATC4/RB1/ATM/CRTC1/ITGAL/MAP2K1/MAP3K3/PRKACB/ATF6B/EP300/LCK/IL2RG/TGFB3/CDKN2B/ELK4/HLA-DRB5/PIK3CD/STAT5A/ADCY1/BAX/PRKACA	7.54631935964704
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	63/1682	155/9376	2.26568984695639	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/CTSS/FCGR3A/HLA-A/HLA-DQA1/MSR1/HLA-DQA2/HLA-DMB/ITGB2/HLA-DQB1/NCF2/HLA-DMA/OLR1/HLA-F/ATP6V0E1/HLA-DRB1/SCARB1/MRC2/LAMP2/CD36/ATP6V0D1/TUBB2A/FCGR1A/ATP6V1G1/COLEC12/TUBA1A/FCGR2A/ITGB1/RAB5A/DYNC1LI2/HLA-E/HLA-DOA/C3/MARCO/THBS3/CORO1A/LAMP1/CD14/ITGAM/THBS1/STX12/TLR4/CYBB/TLR2/ATP6AP1/DYNC1H1/ATP6V0A1/ITGB5/STX18/HLA-DRB5/C1R/ATP6V1B2/TUBA4A/ATP6V1H/TLR6/RAB5B/HGS/STX7/DYNC2H1/ITGA2	7.42893703318872
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	51/1682	115/9376	2.47208809388409	CREB5/CDKN1A/JUND/FOS/CREB3L1/ADCY7/MAPK3/WNK1/MAFB/NR4A2/PLD1/HBEGF/AKAP13/ARRB2/VDR/MEF2A/WNK2/GNAI2/MAPK1/GNAQ/ITPR2/ADCY3/PRKCA/ATF4/GNA13/STK39/SGK1/CREB3L2/EGFR/BCL2/RXRB/ITPR1/RUNX2/MAP2K1/PRKACB/ATF6B/PLCB2/FGFR1/RXRA/GNA11/PRKCB/MEF2D/PDE4B/ARRB1/MMP16/SP1/ARHGEF1/CYP24A1/ADCY1/RAF1/PRKACA	7.426365522477
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	108/1682	333/9376	1.80788636436674	HLA-B/FN1/CREB5/SPP1/HLA-A/CDKN1A/WNT2/CREB3L1/CCND2/HLA-F/ATP6V0E1/HES2/VTN/LAMB2/COL6A1/PIK3R1/LAMA2/FZD2/RHEB/NOTCH2/MAPK3/ATP6V0D1/COL6A2/WNT2B/VEGFA/LLGL2/PDGFRB/CREBBP/FOXO1/TNFRSF1A/MX2/ATP6V1G1/LAMC3/RBPJ/ITGB1/PTGER4/LFNG/HLA-E/FZD1/HES4/MAML2/PTK2/LAMA5/MAPK1/AKT3/FAS/THBS3/COL1A2/ITGA1/NFKB1/PIK3CA/RBL2/THBS1/WNT5B/CDK6/COL4A2/LAMC1/TCF7L2/RFNG/LAMA3/ITGA11/HES1/SOS1/CREB3L2/PPP2CB/JAG1/EGFR/ATP6AP1/WNT4/STAT1/CHD4/IFNAR1/RB1/ATM/MAP2K1/PPP2R5E/COL4A4/TNXB/PRKACB/UBR4/ATP6V0A1/EP300/TRADD/CSNK1A1/ITGB5/FZD7/TSC2/COL4A1/MFNG/PARD6G/UBE3A/WNT9A/PTGS2/TADA3/ATP6V1B2/ATP6V1H/PIK3CD/LAMB3/OASL/RAF1/ITGA3/TCF7L1/BAX/NFX1/LAMB1/COL1A1/PRKACA/ITGA2	7.01840898570603
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	46/1682	100/9376	2.56418549346017	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/CD44/CD37/CD59/HLA-DRB1/CD22/CD36/CSF1/IL4R/CD4/IL6R/IL1R1/FCGR1A/CSF2RA/HLA-DOA/CD9/IL11RA/ITGA1/CD1D/CD14/ITGAM/CSF1R/KITLG/IL11/CD3E/CD3D/IL1B/ANPEP/MME/CD33/EPOR/HLA-DRB5/CD8B/CD2/CD38/CD8A/CSF3R/ITGA3/ITGA2	7.35242201565945
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	58/1682	142/9376	2.27683341427878	FCGR3A/TREM2/JUND/TGFBR1/TYROBP/NCF2/FOS/SQSTM1/SPI1/NFKBIA/FOSB/TGFB2/LILRB4/PIK3R1/MAPK3/CSF1/LILRB3/TGFBR2/JUN/CYLD/SYK/JUNB/SOCS1/TNFRSF1A/IL1R1/LCP2/FCGR1A/FCGR2A/IFNGR2/SIRPA/OSCAR/MAPK1/AKT3/IFNGR1/ITPR2/NFKB1/PIK3CA/LILRB2/CSF1R/BTK/MITF/FHL2/MAPK8/TNFRSF11B/IL1B/LILRB1/ITPR1/STAT1/IFNAR1/MAPK14/MAP2K1/CTSK/LILRA2/LCK/SIRPB1/PLCG2/PIK3CD/TAB2	7.16813241802571
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	56/1682	137/9376	2.27855264414106	CTSS/CTSB/CTSD/FOS/ENDOG/TNFSF10/NFKBIA/GADD45B/CSF2RB/PIK3R1/MAPK3/BCL2A1/CTSO/CAPN2/BIRC3/JUN/TNFRSF1A/TUBA1A/CFLAR/CTSZ/CTSC/MAP3K5/MAPK1/AKT3/FAS/CTSF/CTSH/ITPR2/NFKB1/PDPK1/PIK3CA/ATF4/DAB2IP/XIAP/BBC3/MAPK8/BCL2/ITPR1/GADD45A/ATM/MAP2K1/CTSK/BID/PARP4/ERN1/LMNA/TRAF1/TRADD/MCL1/PTPN13/BCL2L11/TNFRSF10A/TUBA4A/PIK3CD/RAF1/BAX	7.04837427892808
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	46/1682	103/9376	2.48950047908754	FN1/ITGB2/HSPB1/TGFB2/LAMB2/PIK3R1/LAMA2/IL10/CXCL3/IL1R1/LAMC3/CXCL2/RAB5A/GNA15/PTK2/LAMA5/COL3A1/COL1A2/GNAQ/CD1D/CD14/NFKB1/PIK3CA/ITGAM/PRKCA/COL4A2/LAMC1/LAMA3/TLR4/IL1B/TLR2/SERPINB6/COL4A4/PRKACB/PLCB2/COL4A1/GNA11/PRKCB/TGFB3/PIK3CD/LAMB3/RAB5B/ADCY1/LAMB1/COL1A1/PRKACA	7.10676038239438
NA	NA	hsa04518	Integrin signaling	60/1682	154/9376	2.1718115416094	FBN1/FN1/SPP1/ITGB2/HGF/PDGFRA/VCAM1/CCND2/VTN/LAMB2/COL6A1/PIK3R1/LAMA2/FERMT3/ITGAX/FLT1/PDGFB/COL6A2/VEGFA/PDGFRB/PARVG/RAC2/PDGFC/LAMC3/ITGB1/ICAM1/C3/PTK2/LAMA5/AKT3/ITGAD/THBS3/COL1A2/ITGA1/PIK3CA/ITGAM/THBS1/LIMS2/COL4A2/LAMC1/FREM1/LAMA3/ITGA11/TLN2/VEGFC/EGFR/ITGAL/COL4A4/TNXB/FLNB/PDGFD/ITGB5/COL4A1/FLNA/PIK3CD/LAMB3/ITGA3/LAMB1/COL1A1/ITGA2	6.85532605478757
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	73/1682	203/9376	2.00455708955442	FN1/SPP1/HGF/PDGFRA/CCND2/VTN/LAMB2/COL6A1/PIK3R1/LAMA2/MAPK3/FLT1/PDGFB/COL6A2/CAPN2/VEGFA/BIRC3/JUN/PDGFRB/PARVG/RAC2/PDGFC/LAMC3/ITGB1/VAV3/PTK2/LAMA5/MAPK1/AKT3/PPP1R12B/THBS3/COL1A2/ITGA1/PDPK1/PIK3CA/PRKCA/THBS1/COL4A2/SHC2/LAMC1/EMP1/EMP2/XIAP/LAMA3/MAPK8/ITGA11/TLN2/BCAR1/VEGFC/SOS1/EGFR/BCL2/MAP2K1/COL4A4/TNXB/FLNB/RAP1A/PDGFD/ITGB5/COL4A1/FLNA/PRKCB/ARHGAP35/ROCK2/PIK3CD/VAV1/LAMB3/RAF1/ITGA3/RAP1B/LAMB1/COL1A1/ITGA2	6.76533782975812
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	42/1682	93/9376	2.51743316328488	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/FOS/NFKBIA/MAF/HLA-DRB1/NOTCH2/MAPK3/IL4R/CD4/IL2RB/JUN/STAT4/IFNGR2/RBPJ/HLA-DOA/STAT6/MAML2/MAPK1/IFNGR1/RUNX3/NFKB1/CD3E/CD3D/MAPK8/JAG1/JAK3/STAT1/MAPK14/LAT/LCK/IL2RG/HLA-DRB5/NFKBIE/STAT5A/JAK2	6.87589780554526
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	47/1682	110/9376	2.38175332396498	FBN1/DCN/NOG/TGFBR1/PITX2/LTBP1/HAMP/EMP3/BAMBI/TGFB2/BMPR2/MAPK3/SMAD3/GDF6/TGFBR2/FMOD/CREBBP/BMP5/LEFTY2/ACVR2A/BMPR1B/SKIL/MAPK1/SMURF2/SMAD4/THBS1/BMPR1A/PPP2CB/SMAD5/BMP6/NBL1/THSD4/EP300/SMAD7/NCOR1/ID2/TGFB3/CDKN2B/SKI/ACVR1B/SP1/SMAD6/ID4/NRROS/RGMB/CHRD/FST	6.81558683858889
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	111/1682	362/9376	1.70925168012298	FN1/PRLR/CREB5/SPP1/IGF2/CDKN1A/CSH1/HGF/PDGFRA/CREB3L1/CCND2/VTN/LAMB2/COL6A1/PIK3R1/LAMA2/RHEB/MAPK3/FLT1/CSF1/IL4R/PDGFB/COL6A2/OSM/VEGFA/EREG/IL2RB/IL6R/SYK/PDGFRB/FOXO3/FGF7/OSMR/PIK3AP1/PDGFC/LAMC3/ITGB1/GDNF/PKN1/IRS1/FGFR2/PTK2/LAMA5/MAPK1/AKT3/THBS3/PIK3R5/COL1A2/ITGA1/NFKB1/PDPK1/PIK3CA/PRKCA/RBL2/THBS1/LPAR1/ATF4/CSF1R/CDK6/KITLG/COL4A2/YWHAG/LAMC1/CSHL1/FGF2/LAMA3/TLR4/ITGA11/TLR2/VEGFC/SGK1/SOS1/CREB3L2/PPP2CB/EGFR/JAK3/BCL2/IFNAR1/MAP2K1/PPP2R5E/COL4A4/TNXB/GNG12/ATF6B/PDGFD/MCL1/BDNF/ITGB5/TSC2/FGFR1/EPOR/RXRA/COL4A1/BCL2L11/IL2RG/CSH2/LPAR5/PKN2/AREG/SGK3/PIK3CD/GNGT2/LAMB3/CSF3R/LPAR2/JAK2/RAF1/ITGA3/LAMB1/COL1A1/ITGA2	6.4345536249757
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	44/1682	101/9376	2.42841501748272	FN1/SERPINE1/F3/TGFBR1/PLCD3/VCAM1/TGFB2/PIK3R1/MAPK3/SMAD3/TGFBR2/VEGFA/JUN/FOXO1/PIM1/ICAM1/MAPK1/AKT3/SMAD4/COL3A1/COL1A2/NFKB1/PIK3CA/PRKCA/COL4A2/MAPK8/CYBB/IL1B/VEGFC/STAT3/BCL2/STAT1/MAPK14/COL4A4/PLCB2/COL4A1/PRKCB/TGFB3/PLCG2/PIK3CD/STAT5A/JAK2/BAX/COL1A1	6.7480870781786
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	50/1682	122/9376	2.28455585661098	CREB5/CSH1/IGFBP3/FOS/CREB3L1/ADCY7/PIK3R1/MAPK3/JUNB/SOCS1/CREBBP/IRS2/IRS1/PTK2/GNAI2/MAPK1/AKT3/MAP2K3/GNAQ/ITPR2/PIK3CA/ADCY3/PRKCA/ATF4/SHC2/CSHL1/MAPK8/BCAR1/SOS1/CREB3L2/STAT3/ITPR1/STAT1/MAPK14/MAP2K1/PRKACB/ATF6B/EP300/PLCB2/GNA11/PRKCB/CSH2/CACNA1C/PLCG2/PIK3CD/STAT5A/ADCY1/JAK2/RAF1/PRKACA	6.67714341354763
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	75/1682	216/9376	1.93552648962875	NCF2/ABCA1/FOS/TNFSF10/VCAM1/OLR1/NFKBIA/MMP9/LY96/VLDLR/PIK3R1/MAPK3/CD36/ABCG1/CXCL3/CASP1/JUN/TNFRSF1A/CXCL2/PYCARD/HSPA1B/VAV3/HSPA1A/ICAM1/MAP3K5/PTK2/CAMK2D/CAMK2G/NFE2L2/MAPK1/AKT3/FAS/MAP2K3/CD14/NFKB1/PDPK1/PIK3CA/PRKCA/ATF4/CD40/IL18/TLR4/MAPK8/CYBB/IL1B/TLR2/STAT3/BCL2/RXRB/ITPR1/MAPK14/CCL5/SOD2/POU2F2/BID/RAP1A/ERN1/PLCB2/RXRA/MIB1/NLRP3/LYN/TNFRSF10A/ARHGEF1/ROCK2/TLR6/PIK3CD/CCL3/HSPA6/VAV1/TAB2/CALM2/JAK2/BAX/RAP1B	6.503659128665
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	54/1682	138/9376	2.18125420048596	FN1/FOS/NFKBIA/PIK3R1/MAPK3/CD4/IL10/CASP1/JUN/RAC2/LCP2/FCGR2A/PYCARD/ITGB1/VAV3/PKN1/PTK2/MAPK1/AKT3/MAP2K3/GNAQ/NFKB1/PIK3CA/IL18/WAS/TLR4/MAPK8/IL1B/GIT2/BCAR1/WIPF2/MAPK14/WASF2/MAP2K1/RPS6KA3/LAT/LCK/SKAP2/LIMK1/PKN2/NLRP3/ARHGEF7/CD8B/ARHGEF1/ARHGEF12/ROCK2/WASL/PIK3CD/VAV1/TAB2/RPS6KA2/CD8A/BAIAP2/WIPF1	6.53606666323734
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	71/1682	205/9376	1.93061686145993	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-A/CDKN1A/HLA-DQA1/HLA-DQA2/HLA-DMB/TAPBPL/VIM/HLA-DQB1/HLA-DMA/CD44/TAPBP/CCND2/NFKBIA/HLA-F/HLA-DRB1/GADD45B/PIK3R1/JUN/SYK/ENTPD1/RBPJ/HLA-E/HLA-DOA/ICAM1/CD58/AKT3/FAS/MAP2K3/ENTPD8/RUNX3/B2M/NFKB1/PIK3CA/BTK/SAP30L/CDK6/CD40/NCOR2/CD3E/CD3D/MAPK8/HES1/TLR2/STAT3/JAK3/BCL2/STAT1/IFNAR1/MAPK14/RB1/GADD45A/ITGAL/OAS2/BID/TRADD/BCL2L11/CIR1/HLA-DRB5/LYN/DDB2/NFKBIE/PLCG2/PIK3CD/TAB2/USP7/POLK/BAX	6.29886127774537
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	52/1682	133/9376	2.17943193298347	HOMER3/CDKN1A/TGFBR1/PRKAG2/TNFSF10/CCND2/FBXO32/GADD45B/GABARAPL2/TGFB2/PIK3R1/PLK3/GABARAPL1/MAPK3/SMAD3/IL10/TGFBR2/CREBBP/FOXO1/FOXO3/KLF2/IRS2/GABARAP/IRS1/MAPK1/AKT3/SMAD4/PDPK1/PIK3CA/RBL2/CCNG2/MAPK8/SGK1/SOS1/STAT3/EGFR/BCL6/MAPK14/GADD45A/ATM/MAP2K1/SOD2/S1PR4/EP300/BCL2L11/TGFB3/CDKN2B/SGK3/PIK3CD/USP7/RAF1/HOMER1	6.4049356236353
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	48/1682	119/9376	2.2484637136662	CREB5/FOS/VCAM1/CREB3L1/NFKBIA/MMP9/BCL3/PIK3R1/MAPK3/CSF1/CXCL3/BIRC3/CEBPB/JUN/CYLD/JUNB/TNFRSF1A/CXCL2/CFLAR/RHBDF1/ICAM1/MAP3K5/MAPK1/AKT3/FAS/MAP2K3/NFKB1/PIK3CA/ATF4/DAB2IP/XIAP/MAPK8/IL1B/VEGFC/CCL20/CREB3L2/JAG1/MAPK14/RHBDF2/CCL5/MAP2K1/ATF6B/TRAF1/TRADD/PTGS2/PIK3CD/TAB2/TNFRSF1B	6.40821118973995
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	41/1682	95/9376	2.40575755679329	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/ITGB2/HLA-DQB1/HLA-DMA/FOS/ATP6V0E1/HLA-DRB1/TGFB2/TNFSF13B/FLT1/CSF1/ATP6V0D1/CXCL3/VEGFA/JUN/CD86/ATP6V1G1/CXCL2/HLA-DOA/ICAM1/IL18/IL11/TLR4/IL1B/TLR2/CCL20/ATP6AP1/CCL5/ITGAL/CTSK/ATP6V0A1/TGFB3/HLA-DRB5/ATP6V1B2/ATP6V1H/CCL3	6.43868807524159
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	43/1682	103/9376	2.32714175219053	SERPINE1/TGFBR1/FOS/NFKBIA/TGFB2/PIK3R1/MAPK3/C1QA/IL10/C1QB/TGFBR2/JUN/TNFRSF1A/C1QC/IFNGR2/CFLAR/C3/GNA15/GNAI2/MAPK1/AKT3/FAS/GNAQ/IFNGR1/NFKB1/PIK3CA/CD3E/TLR4/CD3D/MAPK8/IL1B/TLR2/PPP2CB/MAPK14/CCL5/PLCB2/ACE/GNA11/TGFB3/TLR6/PIK3CD/CCL3/ADCY1	6.3321083535783
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	40/1682	93/9376	2.39755539360464	FN1/CDKN1A/NFKBIA/GADD45B/LAMB2/PIK3R1/LAMA2/BIRC3/LAMC3/ITGB1/PTK2/LAMA5/AKT3/NFKB1/PIK3CA/RARB/BIRC7/CDK6/COL4A2/LAMC1/XIAP/LAMA3/BCL2/RXRB/RB1/GADD45A/COL4A4/TRAF1/RXRA/COL4A1/CDKN2B/DDB2/PTGS2/PIK3CD/LAMB3/POLK/ITGA3/BAX/LAMB1/ITGA2	6.33269938770283
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	34/1682	73/9376	2.5962569022527	CDKN1A/HGF/GADD45B/PIK3R1/MAPK3/FOXO3/MAPK1/AKT3/PDPK1/PIK3CA/PRKCA/RASSF5/RARB/CDK6/SOS1/STAT3/EGFR/JAK3/RXRB/CDKN2A/RB1/GADD45A/MAP2K1/RXRA/PRKCB/DDB2/EML4/PLCG2/PIK3CD/RASSF1/STAT5A/POLK/RAF1/BAX	6.40140420363362
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	81/1682	250/9376	1.80607847800238	HLA-B/HLA-A/CLTB/TGFBR1/CXCR4/PDGFRA/HLA-F/ASAP3/SMAD3/TGFBR2/AGAP3/PLD1/ARFGAP3/IL2RB/GRK4/ARRB2/BIN1/RAB5A/IST1/HSPA1B/HSPA1A/ARAP1/HLA-E/IGF2R/FGFR2/CYTH1/SMURF2/EHD2/RAB31/ARF1/GIT1/ARAP2/CHMP1A/CLTC/IQSEC1/EHD1/AP2A2/CYTH4/GIT2/SNX1/EGFR/WIPF2/SMAP2/SH3GL1/CHMP1B/RUFY1/SH3GLB2/RABEP1/GBF1/RAB11FIP1/ARFGEF2/VPS35/RAB11FIP2/RAB22A/VPS4B/CYTH3/PDCD6IP/AP2B1/ARFGEF1/ACAP3/IL2RG/ARRB1/ASAP2/PSD3/USP8/PARD6G/WASL/SH3KBP1/VPS36/HSPA6/CYTH2/WWP1/RAB5B/EPN2/ARF4/DNM1/HGS/PSD/STAM/SH3GL3/WIPF1	6.03989850652632
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	75/1682	227/9376	1.84173445709167	HLA-B/CREB5/HLA-A/CDKN1A/TAPBPL/CXCR4/PDGFRA/TAPBP/CREB3L1/NFKBIA/HLA-F/ADCY7/PTGER3/PIK3R1/RHEB/MAPK3/VEGFA/IL6R/AKAP13/TNFRSF1A/IL1R1/RAC2/PTGER2/PTGER4/HLA-E/PTK2/GNAI2/MAPK1/AKT3/FAS/GNAQ/B2M/ITPR2/NFKB1/PIK3CA/ADCY3/PRKCA/ATF4/CDK6/GNA13/IL1B/BCAR1/SOS1/CREB3L2/STAT3/EGFR/CDKN2A/ITPR1/NFATC4/MAPK14/RB1/CCL5/MAP2K1/PRKACB/GNG12/BID/ATF6B/TRADD/PLCB2/TSC2/GNA11/PRKCB/SP1/ARHGEF1/ARHGEF12/ROCK2/PTGS2/PIK3CD/CCL3/GNGT2/CALM2/ADCY1/RAF1/BAX/PRKACA	6.00238383001352
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	92/1682	300/9376	1.70945699564011	IGF2/JUND/TGFBR1/DUSP1/HGF/RASGRF2/FOS/PDGFRA/HSPB1/GADD45B/TGFB2/DUSP2/MAPK3/FLT1/MAP3K2/CSF1/PDGFB/IL1RAP/TGFBR2/RASA1/VEGFA/EREG/JUN/PDGFRB/TNFRSF1A/IL1R1/FGF7/RAC2/PDGFC/MRAS/ARRB2/MAPK8IP2/HSPA1B/HSPA1A/GDNF/MAP3K5/FGFR2/MAPK1/AKT3/FAS/MAP2K3/CD14/NFKB1/PRKCA/ATF4/CSF1R/MAP4K3/KITLG/FGF2/MAPK8/IL1B/VEGFC/MAPK8IP3/SOS1/EGFR/PTPN7/MAPKAPK3/CACNA2D1/MAPK14/CACNA2D4/GADD45A/TAOK1/DUSP10/MAP2K1/MAP3K3/PRKACB/GNG12/RPS6KA3/RAP1A/PDGFD/MAPKAPK2/TRADD/BDNF/FGFR1/FLNA/PRKCB/TGFB3/CACNA1A/ELK4/ARRB1/AREG/DUSP3/CDC25B/CACNA1C/HSPA6/TAB2/RPS6KA2/CACNB1/RAF1/CACNB2/RAP1B/PRKACA	5.83931632285704
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	31/1682	66/9376	2.61823946960689	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/MAF/HLA-DRB1/TGFB2/IL4R/SMAD3/IL10/JUN/STAT4/IFNGR2/HLA-DOA/STAT6/IFNGR1/NFKB1/IL18/TLR4/IL1B/TLR2/STAT3/STAT1/IL2RG/TGFB3/HLA-DRB5/TLR5	6.16825699381826
Organismal Systems	Immune system	hsa04611	Platelet activation	48/1682	126/9376	2.12354906290697	SNAP23/FCER1G/ADCY7/PIK3R1/FERMT3/MAPK3/SYK/LCP2/TBXAS1/FCGR2A/VAMP8/ITGB1/PTGIR/PRKG1/GNAI2/MAPK1/AKT3/COL3A1/PIK3R5/COL1A2/GNAQ/ITPR2/PIK3CA/ADCY3/BTK/GNA13/TLN2/ITPR1/MAPK14/TBXA2R/PRKACB/RAP1A/PLCB2/ARHGAP35/LYN/ARHGEF1/GUCY1A2/ARHGEF12/ROCK2/PLCG2/PIK3CD/P2RX1/PTGS1/ADCY1/RAP1B/COL1A1/PRKACA/ITGA2	5.93647975370402
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	32/1682	70/9376	2.54825887548836	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DQA2/HLA-DMB/ITGB2/HLA-DQB1/HLA-DMA/HLA-F/HLA-DRB1/LAMA2/CD86/RAC2/SGCE/HLA-E/HLA-DOA/ICAM1/EIF4G2/SGCA/ABL1/CD40/SNTB1/SGCD/ITGAL/DAG1/BID/HLA-DRB5/ABL2/DTNA	6.07902062911445
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	77/1682	248/9376	1.73073529975835	FOS/TNFSF10/NFKBIA/LY96/PTPRC/DYNLT1/AHNAK/RHOB/MAPK3/BIRC3/CASP1/JUN/TNFRSF1A/TUBB2A/TUBA1A/AHNAK2/PYCARD/RAB5A/DYNC1LI2/PKN1/CYTH1/NCKAP1L/MAPK1/AKT3/MAP2K3/CD14/NFKB1/PIK3CA/ARF1/IL18/PFN2/S100A10/TCF7L2/TLR4/MAPK8/CYTH4/IL1B/RHOH/TLR2/PLEKHM2/BCL2/MAPK14/NCKAP1/MAP2K1/STX10/PLEKHM1/KLC4/ABI1/DYNC1H1/DYNLT3/TRADD/CYTH3/FLNA/NLRP3/TNFRSF10A/SNX33/NAIP/ROCK2/WASL/TUBA4A/TLR6/PIK3CD/FHOD1/TAB2/KLC1/CYTH2/ARL8B/RAB5B/BRK1/DYNLRB1/RAF1/TXN/TCF7L1/TLR5/BAX/DYNC2H1/FYCO1	5.45281363902774
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	45/1682	120/9376	2.09036860879905	NFKBIA/PIK3R1/ARHGDIG/MAPK3/JUN/FOXO3/IRS1/MAP3K5/CAMK2D/CAMK2G/MAPK1/AKT3/IRAK3/KIDINS220/NFKB1/PDPK1/PIK3CA/MATK/ABL1/ATF4/SHC2/ARHGDIB/MAPK8/SOS1/BCL2/MAPK14/MAP2K1/MAP3K3/RPS6KA3/SH2B3/RAP1A/FRS2/MAPKAPK2/BDNF/ARHGDIA/MAGED1/SH2B1/NFKBIE/PLCG2/PIK3CD/CALM2/RPS6KA2/RAF1/BAX/RAP1B	5.62049845631697
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	65/1682	200/9376	1.81165279429251	FOS/TNFSF10/NFKBIA/TJP1/MAPK3/CASP1/JUN/TNFRSF1A/IL1R1/TUBB2A/TUBA1A/FCGR2A/PYCARD/ITGB1/CYTH1/NCKAP1L/MAPK1/FAS/NFKB1/ARF1/LPAR1/ABL1/GNA13/MYO1D/IL18/ARHGEF2/TLR4/MAPK8/SEC24D/CYTH4/IL1B/MYO5A/WIPF2/MAPK14/WASF2/SEC24A/NCKAP1/MYO1C/ABI1/MYO1G/TRADD/CYTH3/CLDN11/CLDN19/LPAR5/NLRP3/CLDN23/TNFRSF10A/ARHGEF1/ARHGEF12/NAIP/ROCK2/WASL/TUBA4A/RAB1A/TAB2/CYTH2/MYO1F/LPAR2/BRK1/TLR5/BAIAP2/BAX/HCLS1/WIPF1	5.424767462208
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	64/1682	196/9376	1.82018491106312	HLA-B/IL6ST/HLA-A/CDKN1A/FOS/NFKBIA/HLA-F/PIK3R1/MAPK3/PDGFB/CLEC2B/CXCL3/VEGFA/MAP1LC3B/JUN/CD86/SYK/CREBBP/TNFRSF1A/CXCL2/UBB/ZFP36/HLA-E/ICAM1/C3/HCK/MAPK1/AKT3/FAS/PIK3R5/IFNGR1/ITPR2/NFKB1/PIK3CA/CDK6/FGF2/UBC/TCF7L2/MAPK8/STAT3/ITPR1/STAT1/NFATC4/IFNAR1/MAPK14/RB1/MAP2K1/GNG12/BID/MAPKAPK2/EP300/TRADD/MICB/MICA/LYN/PTGS2/PLCG2/PIK3CD/GNGT2/CALM2/JAK2/RAF1/TCF7L1/BAX	5.42551555987099
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	57/1682	168/9376	1.89128588415152	IL6ST/PRLR/CDKN1A/CSH1/FHL1/PDGFRA/CCND2/CSF2RB/PIK3R1/IL4R/PDGFB/IL10/OSM/IL2RB/IL6R/CNTFR/STAT4/PDGFRB/SOCS1/CREBBP/OSMR/IFNGR2/CSF2RA/PIM1/CLCF1/IL13RA1/IL11RA/STAT6/IL27RA/AKT3/IFNGR1/CTF1/CISH/IL15RA/PIK3CA/IL11/PIAS1/CSHL1/SOS1/STAT3/EGFR/JAK3/BCL2/STAT1/SOCS5/IFNAR1/EP300/MCL1/EPOR/IL2RG/CSH2/PIK3CD/CSF3R/STAT5A/JAK2/RAF1/STAM	5.45018892487414
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	65/1682	201/9376	1.80263959631095	HPGD/CDKN1A/IGFBP3/SPI1/CCND2/MAF/MMP9/GADD45B/ARNT2/FLT1/BCL2A1/PLAT/TGFBR2/BIRC3/CEBPB/ASPSCR1/IL2RB/CD86/FOXO1/FCGR1A/KLF3/RUNX1T1/PTK2/HOXA10/REL/NUPR1/NR4A3/CD14/NFKB1/ETV6/JMJD1C/ITGAM/CSF1R/PBX3/CD40/MITF/KMT2A/HOXA11/RXRB/HOXA9/BCL6/RARA/GADD45A/ATM/RUNX2/CEBPA/DDX5/MEIS1/TRAF1/NFKBIZ/AFF1/TFE3/RXRA/FUT8/NCOR1/BMI1/ID2/ELK4/SP1/DDB2/WT1/FLI1/POLK/BAX/RUNX1	5.3782144597414
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	63/1682	193/9376	1.81959547294425	CXCR4/CXCL16/NFKBIA/ADCY7/PIK3R1/XCR1/MAPK3/CXCL3/CXCL14/FOXO3/GRK4/RAC2/CXCL9/FGR/CXCL2/ARRB2/VAV3/HCK/DOCK2/PTK2/GNAI2/MAPK1/AKT3/CCL7/PIK3R5/GNAQ/NFKB1/PIK3CA/ADCY3/SHC2/WAS/BCAR1/SOS1/CCL20/STAT3/JAK3/STAT1/CCL5/MAP2K1/PRKACB/PPBP/GNG12/RAP1A/PLCB2/CXCR6/CCL18/PRKCB/PF4/ARRB1/LYN/ROCK2/PLCG2/PIK3CD/TIAM1/CCL3/GNGT2/VAV1/CCL23/ADCY1/JAK2/RAF1/RAP1B/PRKACA	5.37908560885122
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	47/1682	130/9376	2.01532973566267	CREB5/TGFBR1/FOS/CREB3L1/NFKBIA/MMP9/ADCY7/PIK3R1/MAPK3/TGFBR2/VEGFA/JUN/ARRB2/GNA15/GNAI2/MAPK1/AKT3/COL3A1/COL1A2/NFKB1/PIK3CA/ADCY3/PRKCA/ATF4/COL4A2/SHC2/MAPK8/VEGFC/SOS1/CREB3L2/EGFR/MAPK14/MAP2K1/COL4A4/PRKACB/GNG12/ATF6B/PLCB2/COL4A1/ARRB1/PIK3CD/GNGT2/EDNRB/ADCY1/RAF1/COL1A1/PRKACA	5.45034985091033
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	55/1682	163/9376	1.88090426967604	CREB5/CDKN1A/TGFBR1/FOS/CREB3L1/NFKBIA/MMP9/TGFB2/PIK3R1/MAPK3/SMAD3/TGFBR2/JUN/HSPG2/STAT4/CREBBP/STAT6/MAPK1/AKT3/FAS/SMAD4/MAP2K3/NFKB1/PIK3CA/PRKCA/ATF4/TLR4/MAPK8/TLR2/SOS1/CREB3L2/STAT3/ATP6AP1/JAK3/BCL2/STAT1/NFATC4/IFNAR1/IFIH1/MAPK14/RB1/MAP2K1/BID/ATF6B/EP300/DDB1/PRKCB/TGFB3/DDB2/PIK3CD/TAB2/STAT5A/JAK2/RAF1/BAX	5.30450086479645
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	32/1682	77/9376	2.31659897771669	CDKN1A/TGFBR1/GADD45B/TGFB2/PIK3R1/MAPK3/SMAD3/TGFBR2/VEGFA/PLD1/RAC2/RALGDS/MAPK1/AKT3/SMAD4/NFKB1/PIK3CA/CDK6/MAPK8/STAT3/EGFR/CDKN2A/STAT1/RB1/GADD45A/MAP2K1/TGFB3/DDB2/PIK3CD/POLK/RAF1/BAX	5.42379535999412
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	53/1682	157/9376	1.8817755629104	ABCA1/HAVCR2/DUSP2/MAPK3/CD36/LRP1/C1QA/IL10/C1QB/CEBPB/CASP1/CPT1A/C1QC/PTGER2/SPHK1/GULP1/AXL/RAB5A/PTGER4/SIRPA/ADAM10/ALOX5/PTK2/CAMK2D/CAMK2G/MAPK1/STAB2/PROS1/PLA2G15/LIPA/THBS1/GAS6/ANO6/TMEM30A/BCAR1/SGK1/NFATC4/MAPK14/MAP2K1/GPR132/MAPKAPK2/ITGB5/EPOR/RXRA/SIRPB1/SIGLEC10/RAB14/PTGS2/NR1H2/CH25H/RAB5B/JAK2/MFGE8	5.20940977358133
Human Diseases	Cancer: specific types	hsa05214	Glioma	31/1682	76/9376	2.27373427623756	CDKN1A/PDGFRA/GADD45B/PIK3R1/MAPK3/PDGFB/PDGFRB/CAMK2D/CAMK2G/CAMK1D/MAPK1/AKT3/PIK3CA/PRKCA/CDK6/SHC2/SOS1/EGFR/CDKN2A/RB1/GADD45A/MAP2K1/CAMK1/PRKCB/DDB2/PLCG2/PIK3CD/CALM2/POLK/RAF1/BAX	5.21274764389029
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	34/1682	87/9376	2.17846843522353	CDKN1A/TGFBR1/FOS/GADD45B/TGFB2/PIK3R1/MAPK3/SMAD3/TGFBR2/EREG/JUN/RAC2/RALGDS/MAPK1/AKT3/SMAD4/PIK3CA/TCF7L2/BBC3/MAPK8/SOS1/EGFR/BCL2/GADD45A/MAP2K1/BCL2L11/TGFB3/AREG/DDB2/PIK3CD/POLK/RAF1/TCF7L1/BAX	5.16316070058243
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	56/1682	173/9376	1.80440296096719	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/TNFSF10/NFKBIA/HLA-DRB1/PIK3R1/MAPK3/CASP1/CREBBP/TNFRSF1A/MX2/IFNGR2/PYCARD/HLA-DOA/ICAM1/MAPK1/AKT3/FAS/IFNGR1/DNAJB1/NFKB1/PIK3CA/PRKCA/CDK6/IL18/ADAR/TLR4/IL1B/CIITA/STAT1/IFNAR1/IFIH1/CCL5/MAP2K1/OAS2/BID/HNRNPUL1/EP300/TRADD/PRKCB/TRIM25/HLA-DRB5/NLRP3/TNFRSF10A/RNASEL/NLRX1/PIK3CD/JAK2/RAF1/BAX	4.99291926990365
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	32/1682	80/9376	2.22972651605232	HGF/PDGFRA/PIK3R1/MAPK3/PDGFB/VEGFA/IL6R/PDGFRB/FOXO3/PDGFC/AXL/FGFR2/MAPK1/AKT3/PIK3CA/PRKCA/GAS6/SHC2/FGF2/SOS1/STAT3/EGFR/BCL2/MAP2K1/PDGFD/BCL2L11/PRKCB/PLCG2/PIK3CD/JAK2/RAF1/BAX	5.16449684627502
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	52/1682	157/9376	1.8462703636102	HLA-B/SERPINE1/HLA-A/CDKN1A/TGFBR1/IGFBP3/ZFP36L1/SQSTM1/CCND2/HLA-F/GADD45B/TGFB2/ZFP36L2/PIK3R1/RHEB/MAPK3/SMAD3/CAPN2/TGFBR2/HIPK3/FOXO1/FOXO3/HIPK2/MRAS/HLA-E/MAPK1/AKT3/MAP2K3/ITPR2/NFKB1/PIK3CA/RBL2/RASSF5/GATA4/CDK6/CDKN2A/ITPR1/NFATC4/MAPK14/RB1/GADD45A/ATM/MAP2K1/MAPKAPK2/TSC2/TRPM7/TGFB3/CDKN2B/HIPK1/PIK3CD/CALM2/RAF1	4.99964989813535
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	70/1682	233/9376	1.67468729746419	FBN1/FBLN1/FN1/BGN/FMNL2/SYNE1/DCN/FHL1/SDC2/VIM/TNNI3/MYOZ1/DES/VCAN/COL6A1/LAMA2/FBLN2/COL6A2/FMNL1/COL11A1/ATP1B1/COL5A2/HSPG2/TNNI2/SGCE/COL5A1/ELN/ITGB1/CSRP2/SUN1/FBN2/COL3A1/THBS3/COL1A2/SGCA/ITGA1/TNNT3/THBS1/COL4A2/ATP1A2/SUN2/AMPD2/TMEM43/SNTB1/FHL2/ITGA11/TLN2/PDLIM4/SGCD/SYNPO2/LMOD1/PDLIM3/ANK2/COL4A4/DAG1/MYOM2/LMNA/ITGB5/DIAPH2/COL4A1/DAAM1/COL5A3/AGRN/PKP2/SYNE2/DTNA/SYNE3/ITGA3/COL1A1/ITGA2	4.87594364179236
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	34/1682	89/9376	2.12951408836457	GJA1/PDGFRA/TJP1/ADCY7/MAPK3/MAP3K2/PDGFB/PDGFRB/TUBB2A/TUBA1A/PDGFC/PRKG1/GNAI2/MAPK1/GNAQ/HTR2B/ITPR2/ADCY3/PRKCA/LPAR1/SOS1/EGFR/ITPR1/MAP2K1/PRKACB/PDGFD/PLCB2/GNA11/PRKCB/GUCY1A2/TUBA4A/ADCY1/RAF1/PRKACA	5.00577673710141
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	57/1682	180/9376	1.76520015854142	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-A/CD74/HLA-DQA1/HLA-DQA2/HLA-DMB/TAPBPL/HLA-DQB1/HLA-DMA/TAPBP/BST2/NFKBIA/HLA-F/HLA-DRB1/PIK3R1/TNFRSF14/RHEB/BIRC3/SYK/TNFRSF1A/IFNGR2/HLA-E/HLA-DOA/C3/AKT3/FAS/IFNGR1/B2M/NFKB1/TNFSF14/PIK3CA/HCFC2/IL1B/TLR2/BCL2/STAT1/IFNAR1/IFIH1/CCL5/OAS2/PILRA/POU2F2/CARD9/BID/TRADD/TSC2/HLA-DRB5/SP100/RNASEL/PIK3CD/TAB2/PILRB/JAK2/BAX	4.84656861411219
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	69/1682	232/9376	1.65787855180614	FN1/ITGB2/CXCR4/PDGFRA/RGCC/PIK3R1/ITGAX/MAPK3/PDGFB/GSN/SSH2/C7/PDGFRB/TMSB4X/FGF7/RAC2/IQGAP2/PDGFC/MRAS/ITGB1/VAV3/FGFR2/NCKAP1L/PTK2/MAPK1/AKT3/PPP1R12B/ITGAD/ITGA1/PIK3CA/ITGAM/GIT1/LPAR1/GNA13/PFN2/FGF2/SCIN/ITGA11/BCAR1/SOS1/EGFR/WASF2/NCKAP1/ITGAL/MAP2K1/GNG12/PDGFD/ITGB5/DIAPH2/FGFR1/ARHGAP35/LIMK1/LPAR5/ARHGEF7/ARHGEF1/ARHGEF12/ROCK2/CHRM5/WASL/PIK3CD/TIAM1/VAV1/LPAR2/BRK1/MSN/RAF1/ITGA3/BAIAP2/ITGA2	4.74399425508862
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	84/1682	298/9376	1.57128378647982	IL6ST/EBI3/PRLR/CSH1/TGFBR1/CXCR4/TNFSF10/CXCL16/TGFB2/BMPR2/GDF15/CSF2RB/TNFSF13B/TNFRSF14/XCR1/INHA/CSF1/IL4R/CD4/IL10/OSM/IL1RAP/GDF6/TNFRSF12A/TGFBR2/IL17RE/CXCL3/IL2RB/IL6R/CNTFR/BMP5/TNFRSF1A/CXCL14/IL1R1/OSMR/CXCL9/IFNGR2/CXCL2/CSF2RA/ACVR2A/CLCF1/BMPR1B/IL1RN/IL13RA1/IL11RA/IL27RA/FAS/CCL7/IFNGR1/CTF1/IL15RA/TNFSF14/TNFSF12/CSF1R/CD40/IL18/IL11/ACKR3/CSHL1/TNFRSF11B/IL1B/BMPR1A/CCL20/IFNAR1/RELL2/CCL5/BMP6/PPBP/IL16/CXCR6/EPOR/CCL18/IL2RG/TGFB3/PF4/CSH2/ACVR1B/TNFRSF10A/CCL3/CCL23/TNFRSF8/CSF3R/TNFRSF1B/TNFRSF10D	4.68584031315791
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	43/1682	125/9376	1.91756480380499	CTSD/FCER1G/SGMS2/PIK3R1/MAPK3/CERS6/PLD1/ASAH1/TNFRSF1A/RAC2/SPHK1/MAP3K5/GNAI2/MAPK1/AKT3/GNAQ/NFKB1/PDPK1/PIK3CA/PRKCA/GNA13/MAPK8/PPP2CB/BCL2/MAPK14/SGMS1/MAP2K1/PPP2R5E/BID/S1PR4/TRADD/PLCB2/CERS2/SMPD1/PRKCB/S1PR3/ROCK2/S1PR5/PIK3CD/ADORA1/RAF1/BAX/SPTLC2	4.8285858281845
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	36/1682	98/9376	2.04770802494601	MARCKS/FCGR3A/PTPRC/ASAP3/PIK3R1/MAPK3/GSN/PLD1/SYK/RAC2/FCGR1A/FCGR2A/SPHK1/BIN1/VAV3/HCK/MAPK1/AKT3/PIK3CA/PRKCA/WAS/SCIN/INPP5D/INPPL1/WASF2/MAP2K1/LAT/MARCKSL1/PRKCB/LIMK1/LYN/ASAP2/PLCG2/PIK3CD/VAV1/RAF1	4.87470868450844
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	64/1682	212/9376	1.68281246494515	ITGB2/HGF/PDGFRA/ADCY7/PIK3R1/MAPK3/FLT1/CSF1/PDGFB/EVL/VEGFA/PDGFRB/FGF7/RAC2/LCP2/DOCK4/PDGFC/RALGDS/MRAS/ITGB1/VAV3/FGFR2/GNAI2/MAPK1/AKT3/MAP2K3/GNAQ/PIK3CA/ADCY3/ITGAM/PRKCA/THBS1/RASSF5/LPAR1/CSF1R/KITLG/FPR1/PFN2/FGF2/TLN2/BCAR1/VEGFC/EGFR/MAPK14/ITGAL/MAP2K1/ADORA2B/LAT/RAP1A/PDGFD/PLCB2/FGFR1/PRKCB/LPAR5/PARD6G/RAPGEF3/PIK3CD/TIAM1/VAV1/CALM2/LPAR2/ADCY1/RAF1/RAP1B	4.70164001391564
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	34/1682	91/9376	2.08271158092799	FOS/NFKBIA/LILRB4/PIK3R1/CD22/MAPK3/LILRB3/CD81/JUN/SYK/CD72/RAC2/PIK3AP1/DAPP1/VAV3/MAPK1/AKT3/NFKB1/PIK3CA/LILRB2/BTK/LILRB1/SOS1/INPP5D/INPPL1/MAP2K1/LILRA2/PRKCB/LYN/NFKBIE/PLCG2/PIK3CD/VAV1/RAF1	4.85249467172383
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	36/1682	99/9376	2.02702410550211	HLA-DRA/HLA-DPA1/HLA-DPB1/FCGR3A/HLA-DQA1/HLA-DQA2/HLA-DMB/ITGB2/HLA-DQB1/FPR3/HLA-DMA/C5AR1/HLA-DRB1/C1QA/C2/IL10/C1QB/C1QC/CFH/FCGR1A/C3AR1/FCGR2A/PTAFR/HLA-DOA/ICAM1/C3/ITGAM/FPR1/SELPLG/CFB/KRT14/ITGAL/HLA-DRB5/C1R/CFI/CAMP	4.80304879883854
Human Diseases	Immune disease	hsa05330	Allograft rejection	19/1682	39/9376	2.71569255160218	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/HLA-F/HLA-DRB1/IL10/CD86/HLA-E/HLA-DOA/FAS/CD40/HLA-DRB5	5.01984876187449
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	30/1682	77/9376	2.1718115416094	CDKN1A/TGFBR1/NFKBIA/GADD45B/TGFB2/PIK3R1/MAPK3/SMAD3/TGFBR2/MAPK1/AKT3/SMAD4/NFKB1/PIK3CA/ABL1/CDK6/SHC2/SOS1/CDKN2A/RB1/GADD45A/MAP2K1/TGFB3/DDB2/PIK3CD/STAT5A/POLK/RAF1/BAX/RUNX1	4.82733627303198
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	24/1682	56/9376	2.38899269577034	ITGB2/NFKBIA/CXCL3/CASP1/CXCL2/PYCARD/EEF1A1/HSPA1B/HSPA1A/C3/CD14/NFKB1/CLK4/ARF1/ITGAM/IL18/TLR4/IL1B/TLR2/NAIP/HSPA6/RAB1A/TLR5/CLK1	4.87425855056636
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	33/1682	89/9376	2.06688132105973	FN1/SPP1/CD44/VTN/LAMB2/COL6A1/LAMA2/CD36/COL6A2/HSPG2/LAMC3/ITGB1/LAMA5/THBS3/COL1A2/ITGA1/THBS1/COL4A2/LAMC1/FREM1/LAMA3/ITGA11/COL4A4/TNXB/DAG1/ITGB5/COL4A1/AGRN/LAMB3/ITGA3/LAMB1/COL1A1/ITGA2	4.72820104965796
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	53/1682	169/9376	1.74815836317711	CTSB/CTSD/SQSTM1/GABARAPL2/LAMP2/DAPK1/PIK3R1/GABARAPL1/RHEB/MAPK3/MAP1LC3B/UBB/CFLAR/MRAS/VAMP8/DEPTOR/IRS2/NBR1/ATG16L2/RB1CC1/GABARAP/IRS1/MAPK1/AKT3/LAMP1/OPTN/ULK2/PDPK1/PIK3CA/UBC/MAPK8/PPP2CB/BCL2/EIF2AK4/ITPR1/MAP2K1/PRKACB/C9orf72/PLEKHM1/RRAGC/ERN1/TSC2/BIRC6/TAX1BP1/WDFY3/PIK3CD/RRAGD/RAB1A/ULK1/CAMKK2/RAF1/STX7/PRKACA	4.58881298597979
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	37/1682	105/9376	1.96428288318895	VCAM1/NFKBIA/GADD45B/LY96/TNFSF13B/BCL2A1/CXCL3/BIRC3/CYLD/SYK/TNFRSF1A/IL1R1/CXCL2/CFLAR/ICAM1/CD14/NFKB1/TNFSF14/BTK/CD40/XIAP/TLR4/IL1B/BCL2/CSNK2A2/GADD45A/ATM/LAT/TRAF1/TRADD/LCK/PRKCB/TRIM25/LYN/PTGS2/PLCG2/TAB2	4.64577700120484
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	41/1682	122/9376	1.87333580242101	SLC16A10/PLCD3/MED13L/PIK3R1/RHEB/NOTCH2/MAPK3/DIO3/ATP1B1/CREBBP/FOXO1/MED13/MAPK1/AKT3/PDPK1/PIK3CA/PRKCA/GATA4/ATP1A2/THRB/RXRB/NCOA1/WNT4/STAT1/ESR1/MAP2K1/PRKACB/MED4/EP300/PLCB2/TSC2/RXRA/NCOR1/PRKCB/MED1/PLCG2/PIK3CD/THRA/NCOA3/RAF1/PRKACA	4.5396145063988
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	49/1682	155/9376	1.76220321429941	CREB5/CDKN1A/WNT2/CREB3L1/ADCY7/SCARB1/HSD3B2/FZD2/MAPK3/WNT2B/AHR/FZD1/CAMK2D/GNAI2/CAMK2G/MAPK1/GNAQ/ITPR2/ADCY3/WNT5B/ATF4/POMC/CDK6/KMT2A/TCF7L2/CREB3L2/EGFR/CDKN2A/ITPR1/WNT4/RB1/MAP2K1/PRKACB/RAP1A/ATF6B/PLCB2/FZD7/KCNK3/GNA11/CDKN2B/CRH/SP1/USP8/CACNA1C/WNT9A/ADCY1/TCF7L1/RAP1B/PRKACA	4.47373398715388
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	35/1682	99/9376	1.97071788034927	CDKN1A/FOS/MMP9/ADCY7/PIK3R1/NOTCH2/MAPK3/JUN/HBEGF/PTK2/MAPK1/AKT3/PIK3CA/ADCY3/SHC2/MAPK8/SOS1/JAG1/EGFR/BCL2/CDKN2A/MAPK14/RB1/ESR1/MAP2K1/PRKACB/NCOR1/MED1/SP1/PIK3CD/NCOA3/ADCY1/RAF1/BAX/PRKACA	4.53972338550245
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	27/1682	69/9376	2.18125420048596	FCER1G/PIK3R1/MAPK3/SYK/RAC2/LCP2/ALOX5AP/VAV3/ALOX5/MAPK1/AKT3/MAP2K3/PDPK1/PIK3CA/PRKCA/BTK/MAPK8/SOS1/INPP5D/MAPK14/MAP2K1/LAT/LYN/PLCG2/PIK3CD/VAV1/RAF1	4.60453307812192
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	50/1682	160/9376	1.74197384066587	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/PTPRF/HLA-A/JAM2/HLA-DQA1/MAG/HLA-DQA2/HLA-DMB/ITGB2/SDC2/HLA-DQB1/HLA-DMA/VCAM1/ESAM/HLA-F/HLA-DRB1/PTPRC/VCAN/CD22/ALCAM/CD4/GLG1/CD99/PVR/CD86/PTPRD/ITGB1/NFASC/HLA-E/CD99L2/HLA-DOA/PDCD1LG2/ICAM1/CD58/ITGAM/CD40/SELPLG/ITGAL/SIGLEC1/NLGN4Y/CLDN11/CLDN19/HLA-DRB5/CLDN23/CD8B/CD2/CD8A	4.42588265478006
Human Diseases	Cancer: specific types	hsa05218	Melanoma	28/1682	73/9376	2.13809391950222	CDKN1A/HGF/PDGFRA/GADD45B/PIK3R1/MAPK3/PDGFB/PDGFRB/FGF7/PDGFC/MAPK1/AKT3/PIK3CA/CDK6/MITF/FGF2/EGFR/CDKN2A/RB1/GADD45A/MAP2K1/PDGFD/FGFR1/DDB2/PIK3CD/POLK/RAF1/BAX	4.56405180779482
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	52/1682	170/9376	1.70508498286354	GSTT1/IGF2/CDKN1A/TGFBR1/HGF/WNT2/GADD45B/TGFB2/PIK3R1/FZD2/MAPK3/SMAD3/WNT2B/TGFBR2/FZD1/SMARCD3/NFE2L2/MAPK1/AKT3/SMAD4/PIK3CA/PRKCA/BRD7/WNT5B/CDK6/SHC2/TCF7L2/SOS1/EGFR/CDKN2A/WNT4/RB1/GADD45A/MAP2K1/FRAT1/CSNK1A1/FZD7/PRKCB/TGFB3/SMARCC2/PBRM1/HMOX1/GSTO1/WNT9A/DDB2/PLCG2/PIK3CD/SMARCD2/POLK/RAF1/TCF7L1/BAX	4.33763478872452
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	35/1682	101/9376	1.93169376390671	WNT2/CREB3L1/ADCY7/FZD2/MAPK3/WNT2B/CREBBP/FZD1/CAMK2D/GNAI2/CAMK2G/MAPK1/GNAQ/ADCY3/PRKCA/WNT5B/POMC/KITLG/MITF/TCF7L2/CREB3L2/WNT4/MAP2K1/PRKACB/EP300/PLCB2/FZD7/PRKCB/WNT9A/CALM2/EDNRB/ADCY1/RAF1/TCF7L1/PRKACA	4.40148736332822
NA	NA	hsa04517	IgSF CAM signaling	81/1682	299/9376	1.5100990618749	PTPRF/JAM2/MAG/ITGB2/PMP22/CD84/NRP2/ESAM/CABLES1/CD48/TJP1/PIK3R1/ITGAX/MAPK3/IL1RAP/MBP/RASA1/SLIT2/SLIT3/LMO7/PVR/CD86/FOXO1/LCP2/TUBB2A/CLMP/TUBA1A/PTPRD/ITGB1/PLXNA4/NFASC/VAV3/TJP2/ICAM1/PTK2/MAPK1/AKT3/CASK/NRP1/DOK1/PDPK1/PIK3CA/ITGAM/PRKCA/GIT1/IL1RAPL1/ABL1/DOK2/MAPK8/BCAR1/INPP5D/EPB41L2/MAPK14/SLAMF7/ANK2/ITGAL/MAP2K1/RAP1A/TRIO/SORBS1/FGFR1/NLGN4Y/LCK/UNC5B/PRKCB/LYN/PPFIA1/CRTAM/CD2/ROBO2/PARD6G/WASL/PLCG2/TUBA4A/PIK3CD/CSK/VAV1/MSN/BAIAP2/RAP1B/LRFN4	4.19123000153202
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	30/1682	82/9376	2.03938400858444	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/CTSS/HLA-A/CD74/HLA-DQA1/CTSB/HLA-DQA2/HLA-DMB/TAPBPL/HLA-DQB1/HLA-DMA/TAPBP/HLA-F/HLA-DRB1/LGMN/CD4/HSPA1B/HSPA1A/HLA-E/HLA-DOA/B2M/CIITA/IFI30/HLA-DRB5/CD8B/HSPA6/CD8A	4.41981575607969
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	32/1682	90/9376	1.98197912537984	FOS/NFKBIA/PIK3R1/MAPK3/CD4/JUN/IFNGR2/MAPK1/AKT3/MAP2K3/IFNGR1/NFKB1/PIK3CA/CD3E/TLR4/CD3D/TLR2/STAT3/EGFR/CSNK2A2/STAT1/MAPK14/MAP2K1/MAP3K3/LAT/LCK/BATF/EML4/NFKBIE/PIK3CD/JAK2/RAF1	4.3765481794477
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	44/1682	139/9376	1.7645317752932	CREB5/CTSD/FOS/CREB3L1/MMP9/ADCY7/PIK3R1/MAPK3/JUN/HBEGF/HSPA1B/HSPA1A/GNAI2/MAPK1/AKT3/GNAQ/ITPR2/PIK3CA/ADCY3/ATF4/POMC/SHC2/SOS1/CREB3L2/EGFR/BCL2/KRT14/NCOA1/ITPR1/RARA/ESR1/MAP2K1/PRKACB/GABBR1/ATF6B/PLCB2/SP1/PIK3CD/HSPA6/NCOA3/CALM2/ADCY1/RAF1/PRKACA	4.24580468015988
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	53/1682	178/9376	1.65976833357827	TLE6/NOTUM/RSPO2/WNT2/CCND2/BAMBI/CTNND2/SERPINF1/MCC/FZD2/SMAD3/RSPO3/WNT2B/PRICKLE1/JUN/CREBBP/RAC2/FRZB/FZD1/ANKRD6/CAMK2D/CAMK2G/SMAD4/TLE4/PRKCA/RYK/WNT5B/TCF7L2/MAPK8/CSNK2A2/WNT4/NFATC4/TLE2/PRKACB/SFRP1/EP300/FRAT1/PLCB2/CSNK1A1/FZD7/DAAM1/TBL1XR1/PRKCB/CELSR1/ROCK2/WNT9A/PRICKLE2/ROR2/CBY1/NKD2/SIAH1/TCF7L1/PRKACA	4.15506008800203
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	55/1682	187/9376	1.63950479121494	TXNIP/CTSB/ANTXR1/NFKBIA/IFI16/GABARAPL2/GABARAPL1/MAPK3/GPSM3/CXCL3/NLRP1/MAP1LC3B/BIRC3/CASP1/JUN/P2RX7/CXCL2/PYCARD/PKN1/GABARAP/MAPK1/NAMPT/PSTPIP1/ITPR2/NFKB1/IL18/AIM2/XIAP/TLR4/MAPK8/CYBB/IL1B/GBP5/BCL2/ANTXR2/ITPR1/STAT1/IFNAR1/MAPK14/CCL5/NEK7/OAS2/GBP3/CARD9/PLCB2/TRPM7/PKN2/NLRP3/NAIP/RNASEL/NLRX1/TAB2/RBCK1/CAMP/TXN	4.13002825701483
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	46/1682	149/9376	1.72092986138266	PDGFRA/FCER1G/ADCY7/PIK3R1/RHEB/MAPK3/PDGFB/PLD1/SYK/PDGFRB/PDGFC/RALGDS/MRAS/SPHK1/CYTH1/MAPK1/AKT3/PIK3R5/PIK3CA/ARF1/ADCY3/PRKCA/DGKH/LPAR1/GNA13/KITLG/SHC2/CYTH4/SOS1/EGFR/MAP2K1/AGPAT4/PDGFD/PLCB2/CYTH3/TSC2/LPAR5/RAPGEF3/PLCG2/PIK3CD/CYTH2/PTGFR/LPAR2/DNM1/ADCY1/RAF1	4.14742395240996
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	31/1682	88/9376	1.96367960220517	SERPINE2/SERPINE1/F3/SERPING1/ITGB2/SERPINA1/CD59/C5AR1/F10/CD46/VTN/CLU/ITGAX/PLAT/C1QA/C2/C1QB/C7/C1QC/CFH/C3AR1/C3/A2M/PROS1/ITGAM/CFB/VSIG4/C4BPB/PLAUR/C1R/CFI	4.24654218013288
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	38/1682	116/9376	1.82606912952561	JAM2/ITGB2/NCF2/CXCR4/VCAM1/ESAM/MMP9/PIK3R1/CD99/RAC2/ITGB1/VAV3/CD99L2/ICAM1/PTK2/GNAI2/PIK3CA/ITGAM/PRKCA/RASSF5/CYBB/RHOH/BCAR1/MAPK14/ITGAL/RAP1A/CLDN11/PRKCB/ARHGAP35/CLDN19/CLDN23/ROCK2/RAPGEF3/PLCG2/PIK3CD/VAV1/MSN/RAP1B	4.18564543861169
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	54/1682	184/9376	1.63594065036447	CXCR4/SEMA6D/EPHB2/BMPR2/PIK3R1/SEMA3C/RHOD/MAPK3/DPYSL2/SSH2/RASA1/PLXNB2/SLIT2/SLIT3/PLXNC1/RAC2/EPHA3/NTN4/ITGB1/EFNB2/SMO/PLXNA4/BMPR1B/SEMA5A/EFNB1/PTK2/CAMK2D/GNAI2/CAMK2G/MAPK1/NRP1/PDPK1/PIK3CA/PRKCA/RYK/WNT5B/ABL1/WNT4/NFATC4/SEMA6B/SEMA4A/UNC5B/LIMK1/EPHA7/ROBO2/ARHGEF12/PARD6G/ROCK2/PLCG2/ABLIM1/PIK3CD/TRPC1/RGS3/RAF1	4.0732684495653
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	23/1682	59/9376	2.1730385537798	ADCY7/PTGER3/PIK3R1/MGLL/FABP4/IRS2/IRS1/PRKG1/GNAI2/AKT3/PIK3CA/ADCY3/ADRB3/NPY1R/PRKACB/PTGS2/PIK3CD/ADORA1/PDE3B/PTGS1/ADCY1/ADRB2/PRKACA	4.22593475050205
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	28/1682	78/9376	2.00103661697003	SERPING1/ITGB2/FOS/LY96/MAPK3/C1QA/C2/IL10/C1QB/CASP1/JUN/C1QC/PYCARD/ITGB1/C3/GNAI2/MAPK1/CD14/NFKB1/ITGAM/TLR4/MAPK8/IL1B/MAPK14/C4BPB/NLRP3/C1R/CALM2	4.15073528768059
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	25/1682	67/9376	2.07996876497418	MAPK3/CREBBP/CAMK2D/CAMK2G/MAPK1/GNAQ/ITPR2/PRKCA/ATF4/ITPR1/MAP2K1/PRKACB/RPS6KA3/RAP1A/EP300/PLCB2/PRKCB/CACNA1C/RAPGEF3/CALM2/RPS6KA2/ADCY1/RAF1/RAP1B/PRKACA	4.14781735180771
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	26/1682	71/9376	2.04129892314649	PRLR/FOS/CCND2/PIK3R1/MAPK3/SOCS1/FOXO3/MAPK1/AKT3/CISH/NFKB1/PIK3CA/SHC2/MAPK8/SOS1/STAT3/GCK/STAT1/SOCS5/MAPK14/ESR1/MAP2K1/PIK3CD/STAT5A/JAK2/RAF1	4.11783506841051
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/1682	75/9376	2.00675386444709	SERPINE1/CDKN1A/IGFBP3/CCND2/GADD45B/SESN3/CD82/FAS/THBS1/CDK6/CCNG2/BBC3/BCL2/CDKN2A/GADD45A/ATM/SESN1/BID/TSC2/ZNF385A/RRM2B/TNFRSF10A/DDB2/GORAB/SIAH1/ZMAT3/BAX	4.09271645679036
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	37/1682	115/9376	1.79347567595513	CREB5/FOS/CREB3L1/ADCY7/PIK3R1/SLC18A3/MAPK3/KCNJ2/CAMK2D/GNAI2/CAMK2G/MAPK1/AKT3/PIK3R5/GNAQ/ITPR2/PIK3CA/ADCY3/PRKCA/ATF4/CREB3L2/BCL2/ITPR1/MAP2K1/PRKACB/GNG12/PLCB2/GNA11/PRKCB/CACNA1A/CACNA1C/CHRM5/PIK3CD/GNGT2/ADCY1/JAK2/PRKACA	4.00291288769927
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	34/1682	103/9376	1.84006557149949	COL17A1/SLC16A10/COL15A1/SLC7A7/COL8A2/COL14A1/COL6A1/DPP4/PRCP/COL6A2/COL11A1/ATP1B1/COL5A2/COL5A1/ELN/COL12A1/COL16A1/COL3A1/COL1A2/CTRB2/SLC1A5/COL4A2/ATP1A2/SLC38A2/CPA1/MME/COL4A4/COL22A1/COL4A1/COL5A3/COL23A1/CPB1/COL8A1/COL1A1	4.00815226713007
Human Diseases	Immune disease	hsa05310	Asthma	15/1682	32/9376	2.61296076099881	PRG2/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/FCER1G/HLA-DRB1/IL10/HLA-DOA/CD40/HLA-DRB5	4.27321672504667
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	25/1682	68/9376	2.04938098901868	SPI1/PIK3R1/MAPK3/BCL2A1/FCGR1A/PIM1/RUNX1T1/MAPK1/AKT3/CD14/NFKB1/PIK3CA/ITGAM/CSF1R/TCF7L2/SOS1/STAT3/RARA/MAP2K1/CEBPA/PIK3CD/STAT5A/RAF1/TCF7L1/RUNX1	4.06052327373247
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	41/1682	133/9376	1.71839825485235	HLA-B/FCGR3A/HLA-A/ITGB2/TYROBP/TNFSF10/FCER1G/CD48/HCST/PIK3R1/MAPK3/SYK/RAC2/LCP2/LAT2/IFNGR2/VAV3/HLA-E/ICAM1/MAPK1/FAS/SH3BP2/IFNGR1/PIK3CA/PRKCA/SHC2/SOS1/IFNAR1/ITGAL/MAP2K1/LAT/BID/MICB/MICA/LCK/PRKCB/TNFRSF10A/PLCG2/PIK3CD/VAV1/RAF1	3.90128030773417
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	45/1682	150/9376	1.67229488703924	CDKN1A/TGFBR1/HGF/WNT2/GADD45B/TGFB2/PIK3R1/FZD2/MAPK3/SMAD3/WNT2B/TGFBR2/FGF7/FZD1/FGFR2/MAPK1/AKT3/SMAD4/PIK3CA/RARB/WNT5B/SHC2/FGF2/TCF7L2/SOS1/EGFR/BCL2/RXRB/WNT4/RB1/GADD45A/MAP2K1/FRAT1/CSNK1A1/FZD7/RXRA/TGFB3/CDKN2B/WNT9A/DDB2/PIK3CD/POLK/RAF1/TCF7L1/BAX	3.8807999470525
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	20/1682	50/9376	2.22972651605232	ITGB2/SDC2/HGF/VCAM1/TGFB2/CD36/LRP1/IL10/CD81/ICAM1/THBS3/THBS1/CD40/IL18/TLR4/HBB/IL1B/TLR2/ITGAL/TGFB3	4.07632100859735
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	34/1682	105/9376	1.80501670347092	LSP1/FCER1G/NFKBIA/BCL3/PIK3R1/PLK3/MAPK3/IL10/CASP1/JUN/CYLD/SYK/MRAS/PYCARD/MAPK1/AKT3/ITPR2/NFKB1/PIK3CA/MAPK8/IL1B/ITPR1/STAT1/NFATC4/MAPK14/CARD9/MAPKAPK2/NLRP3/ARHGEF12/PTGS2/PLCG2/PIK3CD/CALM2/RAF1	3.87845532858861
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	31/1682	93/9376	1.8581054300436	ADCY7/MAPK3/MAP3K2/PLD1/JUN/HBEGF/CAMK2D/CAMK2G/MAPK1/MAP2K3/GNAQ/ITPR2/ADCY3/PRKCA/ATF4/MAPK8/SOS1/EGFR/ITPR1/MAPK14/MAP2K1/MAP3K3/PRKACB/PLCB2/GNA11/PRKCB/CACNA1C/CALM2/ADCY1/RAF1/PRKACA	3.88830650741193
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	59/1682	214/9376	1.53684421083045	HLA-B/HLA-A/TAPBPL/CXCR4/FOS/TAPBP/BST2/NFKBIA/HLA-F/PIK3R1/MAPK3/CD4/JUN/TNFRSF1A/RAC2/SAMHD1/HLA-E/APOBEC3A/PTK2/GNAI2/MAPK1/AKT3/FAS/MAP2K3/GNAQ/B2M/ITPR2/NFKB1/PIK3CA/PRKCA/CD3E/TLR4/CD3D/MAPK8/TLR2/BCL2/ITPR1/NFATC4/MAPK14/AP1S2/ATM/MAP2K1/GNG12/BID/TRADD/DDB1/GNA11/PRKCB/LIMK1/CUL5/PLCG2/PIK3CD/GNGT2/TAB2/CALM2/APOBEC3G/TNFRSF1B/RAF1/BAX	3.71434773818353
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	34/1682	106/9376	1.78798824400422	CREB5/CDKN1A/PDGFRA/CREB3L1/NFKBIA/MMP9/PIK3R1/MAPK3/PDGFB/PLAT/PDGFRB/CREBBP/FOXO1/PDGFC/FGFR2/MAPK1/AKT3/NFKB1/PDPK1/PIK3CA/ATF4/TCF7L2/SOS1/CREB3L2/EGFR/BCL2/RB1/MAP2K1/PDGFD/EP300/FGFR1/PIK3CD/RAF1/TCF7L1	3.81465570819046
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	18/1682	44/9376	2.28040211868987	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/HLA-F/HLA-DRB1/CD86/HLA-E/HLA-DOA/FAS/IL1B/HLA-DRB5	3.98022753889844
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	11/1682	21/9376	2.91987996149708	DSE/CHPF2/UST/CSGALNACT2/CHSY3/CHST7/CHST12/CHST13/B3GALT6/CHST11/CHST15	4.11798130005324
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	32/1682	99/9376	1.80179920489076	FOS/PDGFRA/PIK3R1/RHEB/MAPK3/PDGFB/PLD1/JUN/PDGFRB/RAC2/PDGFC/RALGDS/MAPK1/AKT3/PDPK1/PIK3CA/PRKCA/DGKH/CHKB/WAS/MAPK8/SOS1/EGFR/WASF2/MAP2K1/PDGFD/TSC2/PRKCB/SP1/PIK3CD/GPCPD1/RAF1	3.74974714549421
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	67/1682	253/9376	1.47620233770262	PLCD3/CD44/SQSTM1/NFKBIA/PIK3R1/MAPK3/CAPN2/MAP1LC3B/CASP1/JUN/FOXO1/TNFRSF1A/FOXO3/IL1R1/UBB/PYCARD/ITGB1/HK3/C3/CYTH1/PTK2/MAPK1/AKT3/CD14/ITPR2/NFKB1/PIK3CA/ARF1/IL18/ARHGEF2/PFN2/UBC/TLR4/MAPK8/CYTH4/IL1B/TLN2/BCAR1/EGFR/FNBP1/BCL2/ITPR1/MAPK14/WASF2/ATM/TECPR1/CCL5/CAST/RRAGC/TRADD/PLCB2/CYTH3/NLRP3/NAIP/ROCK2/WASL/PLCG2/PIK3CD/RRAGD/TAB2/CYTH2/UBE2D1/TNIP1/RBCK1/TLR5/BAX/HCLS1	3.59009126562443
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	18/1682	45/9376	2.22972651605232	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/HLA-F/HLA-DRB1/CD86/HLA-E/HLA-DOA/FAS/IL1B/HLA-DRB5	3.86610142004445
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	34/1682	109/9376	1.73877755838942	SPP1/FOS/NFKBIA/LY96/PIK3R1/MAPK3/JUN/CD86/CXCL9/MAPK1/AKT3/IRF5/MAP2K3/CD14/NFKB1/PIK3CA/CD40/TLR4/MAPK8/IL1B/TLR2/STAT1/IFNAR1/MAPK14/CCL5/MAP2K1/CTSK/TLR1/TLR8/TLR6/PIK3CD/CCL3/TAB2/TLR5	3.62727017503835
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	33/1682	105/9376	1.75192797689825	SQSTM1/GABARAPL2/PINK1/GABARAPL1/MAP1LC3B/JUN/FOXO3/AMFR/UBB/MRAS/RAB5A/NBR1/GABARAP/SMURF2/OPTN/ATF4/MITF/UBC/TBC1D15/MAPK8/CSNK2A2/FIS1/TFE3/SP1/RHOT1/BNIP3L/USP8/TAX1BP1/NLRX1/CCZ1/ULK1/SIAH1/RAB5B	3.62268143771653
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	43/1682	148/9376	1.61956486807854	CDKN1A/WNT2/FOS/GADD45B/PIK3R1/FZD2/NOTCH2/MAPK3/WNT2B/JUN/FGF7/FZD1/MAPK1/AKT3/PIK3CA/WNT5B/CDK6/SHC2/FGF2/TCF7L2/HES1/SOS1/JAG1/EGFR/NCOA1/WNT4/RB1/GADD45A/ESR1/MAP2K1/FRAT1/CSNK1A1/FZD7/FGFR1/SP1/WNT9A/DDB2/PIK3CD/NCOA3/POLK/RAF1/TCF7L1/BAX	3.55210987613183
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	63/1682	238/9376	1.47555431209345	IGF2/HGF/RASGRF2/PDGFRA/PIK3R1/MAPK3/FLT1/CSF1/PDGFB/RASA1/VEGFA/PLD1/PDGFRB/FGF7/RAC2/PDGFC/RALGDS/MRAS/RAB5A/FGFR2/REL/MAPK1/AKT3/NFKB1/PIK3CA/PRKCA/RASSF5/ABL1/CSF1R/KITLG/SHC2/FGF2/MAPK8/VEGFC/SOS1/EGFR/ETS2/RASA3/RASA4/MAP2K1/PRKACB/RASAL2/GNG12/LAT/RAP1A/PDGFD/BDNF/FGFR1/PRKCB/RALGAPA1/ABL2/PLCG2/PIK3CD/TIAM1/RASSF1/GNGT2/CALM2/RAB5B/SHOC2/RAF1/RAP1B/RGL2/PRKACA	3.4744460189502
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	42/1682	144/9376	1.62584225128815	IL6ST/KLF4/WNT2/BMPR2/ZFHX3/PIK3R1/FZD2/MAPK3/SMAD3/WNT2B/LEFTY2/ACVR2A/FZD1/BMPR1B/SKIL/FGFR2/MAPK1/AKT3/SMAD4/KAT6A/PIK3CA/WNT5B/FGF2/JARID2/BMPR1A/STAT3/JAK3/WNT4/MAPK14/SMAD5/MAP2K1/MEIS1/FZD7/FGFR1/BMI1/ID2/ACVR1B/WNT9A/PIK3CD/ID4/JAK2/RAF1	3.53851279709535
Human Diseases	Infectious disease: viral	hsa05162	Measles	40/1682	136/9376	1.63950479121494	FOS/CCND2/NFKBIA/CD46/PIK3R1/IL2RB/JUN/MX2/HSPA1B/HSPA1A/AKT3/FAS/NFKB1/PIK3CA/CDK6/ADAR/BBC3/CD3E/TLR4/CD3D/MAPK8/IL1B/TLR2/STAT3/JAK3/BCL2/CSNK2A2/STAT1/IFNAR1/IFIH1/OAS2/BID/TRADD/IL2RG/PIK3CD/HSPA6/TAB2/STAT5A/MSN/BAX	3.51236640128465
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	31/1682	98/9376	1.76330413259239	CREB5/CREB3L1/ADCY7/SCARB1/HSD3B2/NR4A2/ATP1B1/CAMK2D/CAMK2G/CAMK1D/GNAQ/DAGLB/ITPR2/ADCY3/PRKCA/ATF4/POMC/ATP1A2/CREB3L2/ITPR1/PRKACB/ATF6B/PLCB2/KCNK3/CAMK1/GNA11/PRKCB/CACNA1C/CALM2/ADCY1/PRKACA	3.55145249962277
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	29/1682	90/9376	1.79616858237548	CREB5/PRKAG2/CREB3L1/ADCY7/SESN3/PIK3R1/RHEB/FOXO1/FOXO3/IRS2/RB1CC1/IRS1/AKT3/NFKB1/PIK3CA/ADCY3/ATF4/CREB3L2/SESN1/SOD2/PRKACB/ATF6B/TSC2/PIK3CD/ULK1/CAMKK2/ADCY1/BAX/PRKACA	3.54841571441861
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	60/1682	226/9376	1.47990697968074	CREB5/FXYD1/TNNI3/FOS/CREB3L1/NFKBIA/ADCY7/PTGER3/PIK3R1/MAPK3/PDE10A/ATP1B1/PLD1/JUN/CREBBP/RAC2/PTGER2/VAV3/PDE3A/ACOX1/CAMK2D/GNAI2/CAMK2G/MAPK1/AKT3/VIPR2/NFKB1/PIK3CA/ADCY3/POMC/ATP1A2/MAPK8/NPY1R/CREB3L2/MAP2K1/PRKACB/RAP1A/GABBR1/GLI3/EP300/BDNF/SUCNR1/PDE4B/CRH/HCAR2/PPARA/CACNA1C/ROCK2/RAPGEF3/PIK3CD/TIAM1/ADORA1/VAV1/PDE3B/CALM2/ADCY1/RAF1/RAP1B/ADRB2/PRKACA	3.41446984640993
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	24/1682	70/9376	1.91119415661627	PRKAG2/ACSL5/NFKBIA/CD36/CPT1A/TNFRSF1A/IRS2/IRS1/ACSL3/AKT3/NFKB1/POMC/MAPK8/STAT3/RXRB/AGRP/TRADD/RXRA/ACSL1/PPARA/NFKBIE/CAMKK2/TNFRSF1B/JAK2	3.57767564771858
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	24/1682	70/9376	1.91119415661627	CDKN1A/HGF/EPAS1/TGFB2/PIK3R1/MAPK3/ARNT2/PDGFB/VEGFA/JUN/CREBBP/EGLN2/MAPK1/AKT3/PIK3CA/SOS1/MAP2K1/RAP1A/EP300/TFE3/TGFB3/PIK3CD/RAF1/RAP1B	3.57767564771858
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	55/1682	205/9376	1.49554827296192	HLA-B/IL6ST/CREB5/HLA-A/CDKN1A/CREB3L1/CCND2/NFKBIA/HLA-F/PIK3R1/MAPK3/ATP6V0D1/GSN/JUN/SYK/CREBBP/RBPJ/HLA-E/C3/REL/MAPK1/VAC14/NFKB1/PIK3CA/RBL2/ATF4/CDK6/YWHAG/SCIN/CREB3L2/STAT3/JAK3/CDKN2A/CHD4/RB1/PRKACB/UBR4/ATF6B/MAPKAPK2/EP300/TRAF1/TRADD/DDB1/CDKN2B/LYN/SP100/HDAC7/UBE3A/PIK3CD/USP7/STAT5A/HDAC4/BAX/HDAC9/PRKACA	3.35410839528166
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	24/1682	71/9376	1.8842759290583	JAM2/NFKBIA/ATP6V0E1/TJP1/ATP6V0D1/CXCL3/JUN/HBEGF/ATP6V1G1/CXCL2/ADAM10/NFKB1/GIT1/MAPK8/EGFR/ATP6AP1/MAPK14/CCL5/ATP6V0A1/LYN/ATP6V1B2/PLCG2/ATP6V1H/CSK	3.49688485206979
NA	NA	hsa03272	Virion - Hepatitis viruses	18/1682	48/9376	2.09036860879905	SCARB1/LAMP2/DPP4/CD81/HSPG2/IST1/CD9/TGOLN2/LAMP1/CHMP1A/EGFR/CHMP1B/VPS4B/PDCD6IP/CLDN11/CLDN19/CLDN23/CD63	3.54096988159379
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	41/1682	144/9376	1.58713172149557	PRKAG2/C5AR1/NFKBIA/LY96/C1QA/C2/C1QB/CXCL3/LPIN2/CPT1A/FOXO1/TNFRSF1A/FOXO3/C1QC/C3AR1/CXCL2/C3/MAP3K5/ACOX1/AKT3/FAS/MAP2K3/CD14/NFKB1/TCF7L2/TLR4/MAPK8/IL1B/MAPK14/SREBF1/ADH1B/TRADD/MLYCD/PPARA/ALDH9A1/TAB2/ACADM/CAMKK2/ACADVL/FASN/TCF7L1	3.31964341783655
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	21/1682	60/9376	1.95101070154578	HSPB1/PIK3R1/MAPK3/VEGFA/RAC2/SPHK1/PTK2/MAPK1/AKT3/PIK3CA/PRKCA/SHC2/MAPKAPK3/MAPK14/MAP2K1/MAPKAPK2/PRKCB/PTGS2/PLCG2/PIK3CD/RAF1	3.45516532176202
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	25/1682	76/9376	1.83365667438513	ACSL5/OLR1/LPL/CYP27A1/ANGPTL4/CD36/CPT1A/FABP4/SLC27A1/ACOX1/ACSL3/PDPK1/GK/UBC/FABP3/RXRB/ME3/SORBS1/RXRA/ACSL1/FABP5/ACOX2/ME1/PPARA/ACADM	3.41173347242483
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	57/1682	217/9376	1.46422132966569	GSTT1/CREB5/KLF4/FOS/CREB3L1/ADCY7/PIK3R1/NOTCH2/MAPK3/VEGFA/JUN/AHR/FGF7/ARRB2/VDR/GNAI2/MAPK1/AKT3/NFKB1/PIK3CA/ADCY3/PRKCA/ATF4/FGF2/PAQR8/XIAP/MIR29A/ADRB3/SOS1/CREB3L2/JAG1/STAT3/EGFR/BCL2/RXRB/BCL6/RB1/ESR1/MAP2K1/PRKACB/RPS6KA3/ATF6B/RXRA/PRKCB/CACNA1A/ARRB1/PPARA/GSTO1/CACNA1C/PIK3CD/RPS6KA2/STAT5A/ADCY1/JAK2/RAF1/ADRB2/PRKACA	3.2348449671469
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/1682	54/9376	1.96133350949047	HLA-B/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/HLA-F/HLA-DRB1/IL10/CD86/HLA-E/HLA-DOA/FAS/CD40/HLA-DRB5	3.31237085321133
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	21/1682	62/9376	1.88807487246366	TLE6/ATXN1/NOTCH2/CREBBP/RBPJ/LFNG/MAML2/TLE4/NCOR2/NUMB/RFNG/HES1/JAG1/TLE2/EP300/NCSTN/CIR1/MFNG/ATXN1L/SPEN/DTX3	3.28019644074629
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	45/1682	166/9376	1.51110983768606	CREB5/RGS2/CREB3L1/ADCY7/MAPK3/ATP1B1/GTF2I/IRS2/IRS1/PDE3A/MEF2A/PRKG1/GNAI2/MAPK1/AKT3/PIK3R5/GNAQ/ITPR2/ADCY3/GATA4/ATF4/GNA13/ATP1A2/ADRB3/CREB3L2/PPIF/ITPR1/NFATC4/MAP2K1/ATF6B/PLCB2/GNA11/MEF2D/KCNMA1/GUCY1A2/CACNA1C/ROCK2/ADORA1/KCNMB1/PDE3B/CALM2/EDNRB/ADCY1/RAF1/ADRB2	3.10642599701072
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	64/1682	254/9376	1.40455213609595	HGF/PLCD3/CXCR4/PDGFRA/ADCY7/P2RX4/ORAI3/PTGER3/FLT1/PDGFB/VEGFA/PDGFRB/FGF7/P2RX7/PDGFC/SPHK1/PTAFR/ORAI2/GDNF/GNA15/MCOLN1/FGFR2/CAMK2D/CAMK2G/CAMK1D/GNAQ/HTR2B/ITPR2/ADCY3/PRKCA/CYSLTR2/FGF2/PHKB/ADRB3/VEGFC/STIM2/EGFR/PPIF/ITPR1/NFATC4/P2RX6/TBXA2R/PRKACB/ADORA2B/PDGFD/PLCB2/FGFR1/TPCN1/CAMK1/GNA11/PRKCB/CACNA1A/CD38/CACNA1C/CHRM5/PLCG2/CALM2/P2RX1/ITPKA/PTGFR/EDNRB/ADCY1/ADRB2/PRKACA	3.05610918376759
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	30/1682	100/9376	1.67229488703924	IL6ST/CXCR4/TNFSF10/TNFRSF14/XCR1/CSF1/IL10/CXCL3/IL2RB/IL6R/TNFRSF1A/CXCL14/CXCL9/CXCL2/CCL7/TNFSF14/CSF1R/IL18/ACKR3/CCL20/CCL5/PPBP/CCL18/IL2RG/PF4/TNFRSF10A/CCL3/CCL23/TNFRSF1B/TNFRSF10D	3.16010840731433
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	32/1682	109/9376	1.63649652554299	CREB5/PTPRF/PRKAG2/MLXIP/CREB3L1/NFKBIA/PIK3R1/CD36/CPT1A/FOXO1/TNFRSF1A/SLC27A1/IRS2/IRS1/AKT3/NFKB1/PDPK1/PIK3CA/GFPT2/MAPK8/CREB3L2/STAT3/PPP1R3D/SREBF1/PPP1R3C/RPS6KA3/PRKCB/PPARA/PIK3CD/NR1H2/RPS6KA2/GFPT1	3.1250879745871
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	20/1682	59/9376	1.88959874241722	CDKN1A/GADD45B/PIK3R1/MAPK3/FOXO3/MAPK1/AKT3/PDPK1/PIK3CA/TCF7L2/SOS1/EGFR/GADD45A/MAP2K1/DDB2/PIK3CD/POLK/RAF1/TCF7L1/BAX	3.20482752034895
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	32/1682	110/9376	1.62161928440169	SERPINE1/CDKN1A/EPAS1/PIK3R1/MAPK3/FLT1/VEGFA/IL6R/CREBBP/IFNGR2/HK3/PFKFB3/CAMK2D/EGLN2/CAMK2G/MAPK1/AKT3/IFNGR1/NFKB1/PIK3CA/PRKCA/TLR4/CYBB/STAT3/EGFR/BCL2/MAP2K1/EP300/PRKCB/HMOX1/PLCG2/PIK3CD	3.06617696509233
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	16/1682	44/9376	2.02702410550211	CREB5/CREB3L1/ARHGDIG/VAMP2/STX4/RAB5A/DYNC1LI2/ADCY3/ARHGDIB/CREB3L2/PRKACB/DYNC1H1/ARHGDIA/RAB5B/DYNC2H1/PRKACA	3.19258268020887
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/1682	19/9376	2.64046561111459	HEXB/IDS/NAGLU/HEXA/GNS/GALNS/HGSNAT/GUSB/GLB1	3.34655648328616
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	39/1682	142/9376	1.53097419235987	GSTT1/DUSP1/SDC2/NCF2/FOS/SQSTM1/VCAM1/MMP9/BMPR2/PIK3R1/PDGFB/PLAT/VEGFA/JUN/TNFRSF1A/IL1R1/RAC2/KLF2/ACVR2A/ICAM1/BMPR1B/MEF2A/MAP3K5/PTK2/NFE2L2/AKT3/NFKB1/PIK3CA/ARHGEF2/MAPK8/IL1B/BMPR1A/BCL2/MAPK14/HMOX1/GSTO1/PIK3CD/CALM2/TXN	2.98088480362935
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/1682	37/9376	2.10920075842787	CDKN1A/GADD45B/MAPK3/MAPK1/TCF7L2/RXRB/GADD45A/TFG/MAP2K1/RXRA/DDB2/POLK/TCF7L1/BAX	3.16070071830972
Organismal Systems	Endocrine system	hsa04924	Renin secretion	22/1682	69/9376	1.77731823743301	CTSB/KCNJ2/PTGER2/PTGER4/PDE3A/GNAI2/GNAQ/ITPR2/ADRB3/ITPR1/PRKACB/PLCB2/ACE/KCNMA1/GUCY1A2/CACNA1C/REN/ADORA1/PDE3B/CALM2/ADRB2/PRKACA	3.0299892563474
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	21/1682	65/9376	1.80093295527303	CREB5/CREB3L1/ADCY7/SCARB1/HSD3B2/GNAQ/ITPR2/ADCY3/ATF4/POMC/CREB3L2/ITPR1/PRKACB/ATF6B/PLCB2/KCNK3/GNA11/SP1/CACNA1C/ADCY1/PRKACA	3.02954370064438
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	21/1682	65/9376	1.80093295527303	SPP1/PIK3R1/MAPK3/ARRB2/MAPK1/AKT3/GNAQ/ITPR2/PIK3CA/PRKCA/ITPR1/MAP2K1/GABBR1/PLCB2/GNA11/PRKCB/ARRB1/CACNA1C/PIK3CD/TRPC1/RAF1	3.02954370064438
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	26/1682	86/9376	1.68525841329536	CDKN1A/PIK3R1/MAPK3/EREG/JUN/HBEGF/PTK2/CAMK2D/CAMK2G/MAPK1/AKT3/PIK3CA/PRKCA/ABL1/SHC2/MAPK8/SOS1/EGFR/MAP2K1/PRKCB/AREG/ABL2/PLCG2/PIK3CD/STAT5A/RAF1	2.98482097472627
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	41/1682	154/9376	1.48407122009976	CDKN1A/RGS2/PRKAG2/FOS/ADCY7/MAPK3/JUN/KCNJ2/CAMK2D/GNAI2/CAMK2G/CAMK1D/MAPK1/PPP1R12B/PIK3R5/GNAQ/ITPR2/ADCY3/PRKCA/EGFR/ITPR1/NFATC4/CACNA2D1/CACNA2D4/MAP2K1/PRKACB/PLCB2/CAMK1/PRKCB/CD38/GUCY1A2/CACNA1C/ROCK2/PTGS2/CALM2/CAMKK2/CACNB1/ADCY1/RAF1/CACNB2/PRKACA	2.83191104515407
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	20/1682	62/9376	1.79816654520348	PRKAG2/ADCY7/PIK3R1/FOXO1/FOXO3/EIF4EBP2/IRS2/HSPA1B/HSPA1A/IRS1/AKT3/PIK3CA/ADCY3/SOD2/PRKACB/PIK3CD/CRYAB/HSPA6/ADCY1/PRKACA	2.94811073016411
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	17/1682	50/9376	1.89526753864447	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/CXCR4/HLA-DMA/HLA-DRB1/TNFSF13B/IL10/CD86/HLA-DOA/IL15RA/CD40/HLA-DRB5	2.96764998432907
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	23/1682	75/9376	1.70945699564011	GSTT1/CDKN1A/PIK3R1/MAPK3/BIRC3/MAP3K5/MAPK1/AKT3/FAS/PDPK1/PIK3CA/XIAP/BBC3/BCL2/CDKN2A/ATM/BID/ERCC1/GSTO1/REV3L/XPA/PIK3CD/BAX	2.88412731649756
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/1682	93/9376	1.61834989068313	PTPRF/TGFBR1/TJP1/MAPK3/SMAD3/TGFBR2/LMO7/CREBBP/RAC2/SNAI2/MAPK1/SMURF2/SMAD4/WAS/TCF7L2/EGFR/CSNK2A2/WASF2/RAP1A/EP300/SORBS1/FGFR1/ROCK2/WASL/TCF7L1/BAIAP2/RAP1B	2.80190967172708
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	18/1682	55/9376	1.8243216949519	PSAP/HEXB/SGMS2/CERS6/ASAH1/HEXA/SPHK1/B4GALT5/ACER3/ARSA/UGCG/SGMS1/NEU1/GLB1/CERS2/SMPD1/CERK/SPTLC2	2.86661496467109
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	37/1682	138/9376	1.49456306329594	PTPRF/FBP1/PRKAG2/PIK3R1/RHEB/MAPK3/SOCS1/FOXO1/HK3/IRS2/TRIP10/IRS1/MAPK1/AKT3/PDPK1/PIK3CA/SHC2/PHKB/MAPK8/SOS1/RHOQ/GCK/PPP1R3D/INPPL1/SREBF1/MAP2K1/PRKACB/PPP1R3C/PRKAR1A/TSC2/SORBS1/PIK3CD/PDE3B/CALM2/FASN/RAF1/PRKACA	2.73649579366345
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	41/1682	157/9376	1.45571317130804	SERPINE1/TGFBR1/ITGB2/WNT2/CCND2/TGFB2/BMPR2/FZD2/SMAD3/GDF6/WNT2B/TGFBR2/BIRC3/LLGL2/BMP5/FZD1/BMPR1B/SNAI2/TEAD1/SMAD4/YAP1/WNT5B/YWHAG/TCF7L2/BBC3/BMPR1A/PPP2CB/GLI2/WNT4/BMP6/FZD7/SMAD7/ID2/TGFB3/AREG/PARD6G/WNT9A/RASSF1/NKD2/AMOT/TCF7L1	2.69229126822955
Organismal Systems	Nervous system	hsa04730	Long-term depression	19/1682	60/9376	1.76520015854142	MAPK3/PRKG1/GNAI2/MAPK1/GNAQ/ITPR2/PRKCA/GNA13/PPP2CB/ITPR1/MAP2K1/PLCB2/GNA11/PRKCB/CACNA1A/CRH/LYN/GUCY1A2/RAF1	2.78008759281227
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	18/1682	56/9376	1.79174452182776	CCND2/GAS1/ARRB2/SMO/SMURF2/BCL2/GLI2/PRKACB/DISP1/CDON/GLI3/CSNK1A1/SCUBE2/ARRB1/EVC2/CSNK1G3/SPOPL/PRKACA	2.77839294413474
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	17/1682	52/9376	1.82237263331199	APOE/ABCA1/LPL/CYP27A1/SCARB1/ANGPTL4/CD36/MYLIP/LRP1/APOC1/APOC2/LIPA/TSPO/NPC1/SOAT1/NPC2/LCAT	2.78030046220673
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	8/1682	18/9376	2.4774739067248	HEXB/HEXA/AGA/MAN2B2/MANBA/NEU1/GLB1/FUCA1	2.93350676935205
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	14/1682	41/9376	1.90342507467881	CDKN1A/MMP9/DAPK1/MAPK3/VEGFA/HBEGF/MAPK1/THBS1/EGFR/CDKN2A/RB1/MAP2K1/RASSF1/RAF1	2.71050024239301
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	7/1682	15/9376	2.60134760206104	HEXB/ST3GAL5/HEXA/ST6GALNAC6/ST3GAL2/GLB1/B3GALT4	2.90196829719341
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	40/1682	158/9376	1.41121931395716	WNT2/PIK3R1/FZD2/RHEB/MAPK3/WNT2B/LPIN2/TNFRSF1A/ATP6V1G1/DEPTOR/FZD1/IRS1/MAPK1/AKT3/ULK2/PDPK1/PIK3CA/PRKCA/WNT5B/CAB39/SGK1/SOS1/WNT4/LAMTOR4/MAP2K1/RPS6KA3/RRAGC/FZD7/TSC2/PRKCB/RICTOR/MAPKAP1/WNT9A/ATP6V1B2/ATP6V1H/PIK3CD/RRAGD/ULK1/RPS6KA2/RAF1	2.43728456818013
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	19/1682	63/9376	1.68114300813468	CDKN1A/WNT2/GADD45B/FZD2/WNT2B/SMO/FZD1/WNT5B/TCF7L2/GLI2/WNT4/GADD45A/GLI3/FZD7/WNT9A/DDB2/POLK/TCF7L1/BAX	2.53621647401127
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	36/1682	140/9376	1.4333956174622	SERPINE1/SPP1/TGFBR1/PRKAG2/ADCY7/MAPK3/SMAD3/PLAT/MAP1LC3B/KLF2/MRAS/SPHK1/MEF2A/GNAI2/MAPK1/AKT3/SMAD4/PIK3R5/GNAQ/ITPR2/ADCY3/GNA13/JAG1/ITPR1/MAP2K1/PRKACB/GNG12/PLCB2/MEF2D/GNGT2/PDE3B/CALM2/HDAC4/ADCY1/RAF1/PRKACA	2.41562276646432
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	27/1682	99/9376	1.52026807912658	ADCY7/PIK3R1/IL1RAP/IL1R1/PTGER2/PTGER4/CAMK2D/CAMK2G/MAP2K3/GNAQ/HTR2B/ITPR2/PIK3CA/ADCY3/PRKCA/MAPK8/IL1B/ITPR1/MAPK14/PRKACB/PLCB2/PRKCB/PLCG2/PIK3CD/CALM2/ADCY1/PRKACA	2.4331200788138
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	24/1682	86/9376	1.55562315073418	CREB5/CREB3L1/ADCY7/ATP1B1/VAMP2/CAMK2D/CAMK2G/GNAQ/ADCY3/PRKCA/ATF4/ATP1A2/CREB3L2/GCK/PRKACB/ATF6B/PLCB2/GNA11/PRKCB/KCNMA1/CACNA1C/KCNMB1/ADCY1/PRKACA	2.42016092349683
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	24/1682	86/9376	1.55562315073418	GJA1/DES/LAMA2/SGCE/ITGB1/SGCA/ITGA1/TCF7L2/SNTB1/ITGA11/SGCD/CACNA2D1/CACNA2D4/DAG1/LMNA/ITGB5/PKP2/CACNA1C/DTNA/CACNB1/ITGA3/CACNB2/TCF7L1/ITGA2	2.42016092349683
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	21/1682	73/9376	1.60357043962667	CXCR4/BST2/CD4/CREBBP/MX2/SERINC3/SAMHD1/APOBEC3A/ELL2/MDFIC/MAP1B/AFF4/ELL/FEZ1/VPS4B/EP300/PDCD6IP/SUPT5H/RANBP2/APOBEC3G/HGS	2.42047401264956
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	28/1682	105/9376	1.48648434403488	TNNI3/ADCY7/TGFB2/DES/LAMA2/SGCE/ITGB1/SGCA/ITGA1/ADCY3/SNTB1/ITGA11/SGCD/CACNA2D1/CACNA2D4/PRKACB/DAG1/LMNA/ITGB5/TGFB3/CACNA1C/DTNA/CACNB1/ADCY1/ITGA3/CACNB2/PRKACA/ITGA2	2.34381198335614
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	11/1682	32/9376	1.91617122473246	BIRC3/TNFRSF1A/BIRC7/XIAP/BBC3/MAPK8/BCL2/BID/BCL2L11/BIRC6/BAX	2.42721230125209
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	41/1682	168/9376	1.36039861842478	SQSTM1/TNFSF10/GLUL/FTL/CAPN2/BIRC3/CASP1/CYLD/STAT4/TNFRSF1A/IFNGR2/CFLAR/PYCARD/STAT6/CAMK2D/CAMK2G/FAS/IFNGR1/CHMP1A/XIAP/TLR4/MAPK8/CYBB/IL1B/STAT3/JAK3/BCL2/CHMP1B/STAT1/IFNAR1/BID/VPS4B/TRADD/TRPM7/SMPD1/NLRP3/TNFRSF10A/STAT5A/RBCK1/JAK2/BAX	2.20382774327069
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	31/1682	122/9376	1.41642463109881	FOS/NFKBIA/PTPRC/PIK3R1/MAPK3/CD4/IL10/JUN/LCP2/VAV3/MAPK1/AKT3/NFKB1/PDPK1/PIK3CA/CD3E/CD3D/MAPK8/SOS1/PPP2CB/MAPK14/MAP2K1/PPP2R5E/LAT/LCK/CD8B/NFKBIE/PIK3CD/VAV1/CD8A/RAF1	2.16458238734454
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/1682	37/9376	1.80788636436674	VCAM1/APOL1/IL10/ICAM1/FAS/GNAQ/PRKCA/IL18/HBB/IL1B/PLCB2/PRKCB	2.30209634528721
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	11/1682	33/9376	1.8581054300436	SNAP23/VAMP2/STX11/STX4/VAMP8/VAMP5/STX5/VAMP7/STX18/STX16/STX7	2.30875042626597
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	35/1682	142/9376	1.37395119827168	HERC1/BIRC3/SOCS1/UBB/ANAPC13/UBE2R2/UBE2K/SMURF2/ANAPC16/BIRC7/UBE2L6/PIAS1/UBE2H/UBC/UBE2A/XIAP/SYVN1/TRIP12/UBA7/UBE2B/UBE2E2/STUB1/CDC34/KLHL9/DDB1/BIRC6/WWP2/CUL5/FBXW8/UBE3A/DDB2/UBE2D1/WWP1/SIAH1/CUL7	2.09935899007222
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/1682	42/9376	1.72538361361191	SAT1/ACSL5/FTL/MAP1LC3B/PRNP/SLC40A1/ACSL3/CYBB/SLC39A8/PCBP1/ACSL1/HMOX1/SLC39A14	2.20283024392538
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	12/1682	38/9376	1.76031040740973	PIK3R1/MAPK3/ATP1B1/IRS1/MAPK1/PDPK1/PIK3CA/PRKCA/ATP1A2/SGK1/PRKCB/PIK3CD	2.19572699750419
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	12/1682	38/9376	1.76031040740973	PTPRC/CD4/BTK/CD40/CD3E/CD3D/JAK3/CIITA/LCK/IL2RG/CD8B/CD8A	2.19572699750419
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	15/1682	51/9376	1.63950479121494	ATP6V0E1/TJP1/ATP6V0D1/ATP6V1G1/TJP2/ARF1/ADCY3/PRKCA/ATP6AP1/PRKACB/ATP6V0A1/ATP6V1B2/PLCG2/ATP6V1H/PRKACA	2.1410510049301
Organismal Systems	Digestive system	hsa04970	Salivary secretion	24/1682	93/9376	1.43853323616279	LYZ/ADCY7/ATP1B1/VAMP2/SLC4A2/PRKG1/GNAQ/ITPR2/ADCY3/PRKCA/ATP1A2/ADRB3/ITPR1/PRKACB/PLCB2/PRKCB/KCNMA1/CD38/GUCY1A2/CALM2/ADCY1/CAMP/ADRB2/PRKACA	1.98711204496345
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	20/1682	75/9376	1.48648434403488	CREB5/CREB3L1/ADCY7/ATP1B1/GPX7/GNAQ/ITPR2/ADCY3/PRKCA/ATF4/ATP1A2/CREB3L2/ITPR1/ASGR1/PRKACB/ATF6B/PLCB2/PRKCB/ADCY1/PRKACA	1.97768546127797
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	30/1682	122/9376	1.37073351396659	CREB5/FBP1/PRKAG2/CREB3L1/PIK3R1/RHEB/CD36/CPT1A/FOXO1/FOXO3/IRS2/IRS1/PFKFB3/AKT3/PDPK1/PIK3CA/CAB39/CREB3L2/PPP2CB/SREBF1/PPP2R5E/TSC2/MLYCD/RAB14/PIK3CD/ULK1/CAMKK2/FASN/TBC1D1/RAB2A	1.92707917543912
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	37/1682	156/9376	1.32211347906948	CDKN1A/NFKBIA/SCARB1/PIK3R1/MAPK3/CD81/TNFRSF1A/MX2/CFLAR/MAPK1/AKT3/FAS/NFKB1/PIK3CA/CDK6/YWHAG/PIAS1/SOS1/PPP2CB/STAT3/EGFR/STAT1/IFNAR1/RB1/MAP2K1/OAS2/BID/TRADD/RXRA/CLDN11/CLDN19/CLDN23/PPARA/RNASEL/PIK3CD/RAF1/BAX	1.8968294339316
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	15/1682	53/9376	1.57763668588607	CLTB/ATP1B1/VDR/GNAQ/PRKCA/ATP1A2/CLTC/AP2A2/ESR1/PRKACB/PLCB2/AP2B1/PRKCB/DNM1/PRKACA	1.97168441336395
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	25/1682	99/9376	1.40765562882091	PRKAG2/TNNI3/TGFB2/DES/LAMA2/SGCE/ITGB1/SGCA/ITGA1/SNTB1/ITGA11/SGCD/CACNA2D1/CACNA2D4/DAG1/LMNA/ITGB5/ACE/TGFB3/CACNA1C/DTNA/CACNB1/ITGA3/CACNB2/ITGA2	1.90646925214163
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	20/1682	76/9376	1.4669253395081	ADCY7/ATP1B1/KCNJ2/SLC4A2/CAMK2D/GNAI2/CAMK2G/GNAQ/ITPR2/ADCY3/PRKCA/KCNJ15/ATP1A2/ITPR1/PRKACB/PLCB2/PRKCB/CALM2/ADCY1/PRKACA	1.91088832953695
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	32/1682	133/9376	1.34118888183598	CREB5/FOS/CREB3L1/MAOA/ARRB2/CAMK2D/GNAI2/CAMK2G/AKT3/GNAQ/COMT/ITPR2/PRKCA/ATF4/MAPK8/CREB3L2/PPP2CB/ITPR1/MAPK14/PPP2R5E/PRKACB/GNG12/ATF6B/PLCB2/PRKCB/CLOCK/CACNA1A/ARRB1/CACNA1C/GNGT2/CALM2/PRKACA	1.8528350492696
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/1682	49/9376	1.59266179718023	GALNT7/PLOD3/GXYLT2/GALNT15/LFNG/GALNT6/RFNG/GALNT11/B4GALT2/GALNT3/POFUT2/MFNG/ST6GAL2/GALNT12	1.9447175263986
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	14/1682	49/9376	1.59266179718023	CREB5/CREB3L1/FOSB/MAOA/JUN/GNAI2/NFKB1/ATF4/CREB3L2/GPSM1/PRKACB/ATF6B/BDNF/PRKACA	1.9447175263986
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	16/1682	59/9376	1.51167899393378	ENPP1/DPYD/ENTPD1/DCTD/NME3/NT5E/ENTPD8/UPP1/NME4/ENTPD4/TK2/CMPK2/RRM2B/UCK1/NT5C2/AK9	1.84335121347816
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	28/1682	116/9376	1.34552462175571	HOMER3/GLUL/ADCY7/MAPK3/PLD1/SLC17A8/SLC1A3/GNAI2/MAPK1/GNAQ/ITPR2/ADCY3/PRKCA/SLC38A2/ITPR1/PRKACB/GNG12/GLS/PLCB2/PRKCB/CACNA1A/SLC38A1/CACNA1C/GNGT2/TRPC1/ADCY1/HOMER1/PRKACA	1.75075366611311
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	24/1682	97/9376	1.37921227797051	FOS/ADCY7/MAPK3/PRKG1/CAMK2D/GNAI2/CAMK2G/MAPK1/GNAQ/ADCY3/PRKCA/ITPR1/PRKACB/GNG12/PLCB2/PER1/PRKCB/NOS1AP/GUCY1A2/CACNA1C/GNGT2/CALM2/ADCY1/PRKACA	1.75525497645371
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	11/1682	38/9376	1.61361787345892	HEXB/RENBP/HEXA/HK3/GFPT2/UGDH/GCK/GNPDA1/PGM3/GFPT1/GNE	1.77208850197783
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	13/1682	47/9376	1.54183216535533	PIK3R1/MAPK3/SOCS1/HK3/IRS2/IRS1/MAPK1/PIK3CA/MAPK8/GCK/CACNA1A/CACNA1C/PIK3CD	1.74107992610558
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1682	71/9376	1.41320694679372	PDGFRA/PIK3R1/MAPK3/PDGFRB/HK3/FGFR2/MAPK1/AKT3/PIK3CA/SLC1A5/GCK/EGFR/MAP2K1/GLS/FGFR1/PIK3CD/SIRT6/RAF1	1.63403420304763
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	31/1682	134/9376	1.28958063428399	ADCY7/MAPK3/ADM/PTGIR/PRKG1/MAPK1/PPP1R12B/GNAQ/ITPR2/ADCY3/PRKCA/GNA13/ITPR1/MAP2K1/PRKACB/ADORA2B/PLCB2/GNA11/PRKCB/KCNMA1/ARHGEF1/CALD1/GUCY1A2/ARHGEF12/CACNA1C/ROCK2/KCNMB1/CALM2/ADCY1/RAF1/PRKACA	1.57856138590352
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	35/1682	154/9376	1.26689006593882	CREB5/TNNI3/CREB3L1/ADCY7/MAPK3/ATP1B1/CAMK2D/GNAI2/CAMK2G/MAPK1/AKT3/PIK3R5/GNAQ/ADCY3/PRKCA/ATF4/ATP1A2/CREB3L2/PPP2CB/BCL2/CACNA2D1/MAPK14/CACNA2D4/PPP2R5E/PRKACB/ATF6B/PLCB2/CACNA1C/RAPGEF3/CALM2/CACNB1/ADCY1/CACNB2/ADRB2/PRKACA	1.56135893684875
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	39/1682	174/9376	1.24941572020173	MAN1A1/MBTPS1/SEC31A/CAPN2/PPP1R15A/OS9/HERPUD1/AMFR/SEC62/HSPA1B/HSPA1A/MAP3K5/NFE2L2/RRBP1/DNAJB1/EDEM3/ATF4/DNAJC5B/MAPK8/SEC24D/BCL2/DNAJB2/SYVN1/SEC24A/SEL1L/UBQLN4/MAN1C1/STUB1/BCAP29/UBXN6/UGGT2/ATF6B/ERN1/RNF185/CRYAB/HSPA6/UBE2D1/DERL3/BAX	1.55267255104605
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	27/1682	115/9376	1.30875252029158	DUSP1/MAPK3/MAOA/KCND2/ALOX5/GNAI2/MAPK1/GNAQ/HTR2B/ITPR2/PRKCA/ITPR1/MAP2K1/PRKACB/GNG12/PLCB2/PRKCB/CACNA1A/SLC6A4/CACNA1C/RAPGEF3/PTGS2/GNGT2/TRPC1/PTGS1/RAF1/PRKACA	1.55758957714374
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/1682	107/9376	1.3024103481614	CREB5/FBP1/PRKAG2/CREB3L1/CPT1A/CREBBP/FOXO1/CAMK2D/CAMK2G/AKT3/GNAQ/ITPR2/ATF4/SIK1/PHKB/CREB3L2/GCK/ITPR1/PRKACB/EP300/PLCB2/PPARA/PDE3B/CALM2/PRKACA	1.47093891880455
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/1682	36/9376	1.548421191703	GALNT7/B3GNT3/GALNT15/GALNT6/B4GALT5/ST3GAL2/GALNT11/GALNT3/ST6GALNAC2/GALNT12	1.54139726251974
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	23/1682	98/9376	1.30825790482662	PLCD3/PIK3R1/ITPR2/PIK3CA/PRKCA/DGKH/IPMK/CDIPT/INPP5D/ITPR1/INPPL1/PLCB2/PRKCB/SACM1L/INPP1/INPP5B/PLCG2/PIK3CD/CALM2/PI4KA/MTMR1/ITPKA/PI4K2A	1.43424260380569
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/1682	69/9376	1.37338227438005	CREB5/FOS/CREB3L1/FOSB/MAOA/JUN/CAMK2D/CAMK2G/PRKCA/ATF4/CREB3L2/PRKACB/ATF6B/PRKCB/CACNA1C/CALM2/PRKACA	1.45544543457289
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/1682	23/9376	1.69653104482242	CTSA/PRCP/ATP6AP2/ANPEP/MME/ACE/REN	1.56369292703085
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/1682	94/9376	1.30462721683912	JUND/FOS/NFKBIA/MMP9/FOSB/MAPK3/IL17RE/CXCL3/CEBPB/JUN/CXCL2/MAPK1/CCL7/NFKB1/MAPK8/IL1B/CCL20/MAPK14/TRADD/PTGS2/TAB2/MAPK6	1.38782398970423
Human Diseases	Substance dependence	hsa05032	Morphine addiction	21/1682	91/9376	1.28638068233788	ADCY7/PDE10A/GRK4/ARRB2/PDE3A/GNAI2/ADCY3/PRKCA/PRKACB/GNG12/GABBR1/PRKCB/PDE4B/CACNA1A/ARRB1/PDE7B/ADORA1/GNGT2/PDE3B/ADCY1/PRKACA	1.28350038884603
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1682	20/9376	1.67229488703924	GMDS/UGDH/NPL/CYB5R1/CYB5R3/GNE	1.40718838755197
NA	NA	hsa04081	Hormone signaling	46/1682	219/9376	1.17086095591788	PRLR/SLC16A10/IGF2/CSH1/HAMP/ADCY7/PIK3R1/GUCA2A/IRS2/SLC40A1/IRS1/BMPR1B/GNA15/PRKG1/GNAI2/SMAD4/GNAQ/VIPR2/PIK3CA/ADCY3/POMC/GNA13/CSHL1/ADRB3/BMPR1A/STAT3/THRB/ESR1/SMAD5/PRKACB/GNG12/PLCB2/EPOR/GNA11/CSH2/CRH/NPR3/RAPGEF3/PIK3CD/THRA/GNGT2/STAT5A/ADCY1/JAK2/ADRB2/PRKACA	1.19621935494166
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1682	16/9376	1.74197384066587	HEXB/HEXA/GBGT1/ST3GAL2/NAGA	1.38877920132895
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/1682	44/9376	1.3935790725327	MAN1A1/HEXB/HEXA/MGAT2/MGAT4A/CHST9/B4GALT2/MAN1C1/MGAT1/MGAT4B/FUT8	1.22347053348495
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	49/1682	238/9376	1.14765335385046	RPS4Y1/IL6ST/FOS/C5AR1/NFKBIA/PIK3R1/MAPK3/C1QA/C2/C1QB/C7/IL6R/CASP1/JUN/SYK/HBEGF/TNFRSF1A/C1QC/MX2/C3AR1/FCGR2A/C3/MAPK1/NRP1/NFKB1/PIK3CA/PRKCA/ADAR/TLR4/MAPK8/CYBB/IL1B/TLR2/STAT3/EGFR/CFB/STAT1/IFNAR1/IFIH1/MAPK14/OAS2/ACE/PRKCB/TLR8/NLRP3/C1R/PLCG2/PIK3CD/TAB2	1.07876975231708
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	20/1682	89/9376	1.25265534609681	GLUL/ADCY7/GABARAPL2/GABARAPL1/GABARAP/GNAI2/ADCY3/PRKCA/SLC38A2/PRKACB/GNG12/GLS/GABBR1/PRKCB/CACNA1A/SLC38A1/CACNA1C/GNGT2/ADCY1/PRKACA	1.11971711289314
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/1682	79/9376	1.27009738256145	SLC6A2/CLTB/ATP6V0E1/SLC18A3/ATP6V0D1/VAMP2/ATP6V1G1/SLC17A8/SLC1A3/CLTC/AP2A2/ATP6V0A1/AP2B1/CACNA1A/SLC6A4/ATP6V1B2/ATP6V1H/DNM1	1.12715865120132
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	24/1682	110/9376	1.21621446330126	ADCY7/PIK3R1/MAPK3/ANAPC13/CPEB2/GNAI2/MAPK1/AKT3/ANAPC16/PIK3CA/ADCY3/MAPK8/MAPK14/MAP2K1/PRKACB/RPS6KA3/CDC25B/MAD2L2/PIK3CD/PDE3B/RPS6KA2/ADCY1/RAF1/PRKACA	1.0664916992275
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/1682	17/9376	1.63950479121494	CYP27A1/CYP39A1/HSD3B7/ACOX2/CH25H	1.23388897168802
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1682	17/9376	1.63950479121494	NRP2/LAMP2/LAMP1/PCDH7/DAG1	1.23388897168802
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/1682	22/9376	1.52026807912658	AOC1/MAOA/HNMT/ALDH3B1/ALDH9A1/AMDHD1	1.14225319446242
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	42/1682	205/9376	1.14205504480729	TGFBR1/CTSD/NCF2/TNNI3/MMP9/PDK4/TGFB2/PIK3R1/CD36/SMAD3/TGFBR2/RAC2/IRS1/MT-ND4L/CAMK2D/CAMK2G/AKT3/COL3A1/MPC1/COL1A2/MT-ND2/NFKB1/PIK3CA/PRKCA/GFPT2/MAPK8/CYBB/PPIF/MT-ND3/MAPK14/PLCB2/ACE/COX7A1/PRKCB/TGFB3/SP1/PPARA/REN/PIK3CD/GFPT1/NDUFS1/COL1A1	0.9614966782799
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	40/1682	195/9376	1.14344949541145	FCGR3A/ITGB2/NCF2/FPR3/C5AR1/PIK3R1/MAPK3/AQP9/CASP1/SYK/RAC2/FCGR1A/FCGR2A/C3/MAPK1/AKT3/NFKB1/PIK3CA/ITGAM/PRKCA/FPR1/TLR4/CYBB/TLR2/PPIF/SELPLG/MAPK14/ITGAL/MAP2K1/PLCB2/PRKCB/TLR8/HDAC7/SIGLEC9/PLCG2/PIK3CD/HDAC4/CAMP/RAF1/HDAC9	0.946441728144968
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	64/1682	323/9376	1.10450849092375	TIMP3/MARCKS/CDKN1A/VIM/CD44/ZEB2/PDGFRA/CCND2/MMP9/TGFB2/BMPR2/PIK3R1/NOTCH2/MAPK3/PDGFB/VEGFA/PDGFRB/FOXP1/SOCS1/CREBBP/DICER1/PIM1/IRS2/IRS1/MAPK1/NFKB1/PIK3CA/PRKCA/THBS1/ABL1/CDK6/SOX4/RECK/MIR29A/SOS1/STAT3/EGFR/BCL2/CDKN2A/ATM/BMF/MAP2K1/FSCN1/TNXB/GLS/EP300/MCL1/BCL2L11/BMI1/PRKCB/ST14/MMP16/HMOX1/CDC25B/PTGS2/PLCG2/PIK3CD/RASSF1/ZFPM2/BCL2L2/PDCD4/CYP24A1/HDAC4/RAF1	0.893673995029931
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	35/1682	170/9376	1.14765335385046	JAM2/PRKAG2/TJP1/LLGL2/JUN/AMOTL2/TUBA1A/ITGB1/TJP2/MAP3K5/CD1D/GATA4/ARHGEF2/WAS/YBX3/MAPK8/PPP2CB/MICALL2/PRKACB/AMOTL1/RAP1A/CLDN11/CLDN19/CLDN23/SYMPK/PARD6G/ROCK2/TUBA4A/TIAM1/SYNPO/AMOT/MSN/HCLS1/RUNX1/PRKACA	0.908353375691672
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/1682	52/9376	1.28638068233788	HSD17B2/ADCY7/SCARB1/HSD3B2/ALOX5/ADCY3/BMP6/PRKACB/PTGS2/HSD17B1/ADCY1/PRKACA	0.968203842416781
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	18/1682	83/9376	1.20888787014885	CREBBP/PHC2/CBX4/JARID2/ASXL2/LCOR/EP300/CBX6/PHC3/USP16/MBD6/BMI1/PHF1/DCAF7/FBRS/UBE2D1/USP7/MGA	0.893710462867026
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/1682	63/9376	1.2387369533624	PIPOX/PLOD2/ASH1L/PLOD3/PRDM6/PRDM2/KMT2E/SMYD3/KMT2A/KMT2C/KMT2B/ALDH9A1/SETD2/SETD1A	0.888930205319308
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/1682	38/9376	1.32023280555729	ENPP1/QPRT/NT5E/NMNAT2/NAMPT/NNT/CD38/NT5C2/SIRT6	0.924811510925094
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1682	14/9376	1.59266179718023	CHST2/ST3GAL2/B4GALT2/FUT8	1.03755033754952
NA	NA	hsa04519	Cadherin signaling	78/1682	404/9376	1.07622938274803	GJA1/CDH11/VIM/PCDH10/WNT2/PDGFRA/NFKBIA/TJP1/CTNND2/LHFPL2/DES/FZD2/PCDH18/MAPK3/WNT2B/EVL/PRICKLE1/PDGFRB/CREBBP/RAC2/AMOTL2/MRAS/ADAM10/VAV3/FZD1/ANKRD6/TEAD1/NCKAP1L/PTK2/MAPK1/MAP2K3/NFKB1/YAP1/FAT1/RYK/WNT5B/MYO1D/YWHAG/PCDH7/TCF7L2/MAPK8/PKP1/EGFR/KRT14/WNT4/MAPK14/TAOK1/NCKAP1/MYO1C/ATN1/DCHS1/MAP2K1/AMOTL1/TMC4/MYO1G/EP300/CSNK1A1/FZD7/NCSTN/FGFR1/CDH18/DAAM1/ARHGAP35/CELSR1/CDH16/PKP2/ROCK2/WNT9A/FAT2/PRICKLE2/VAV1/CDH8/MYO1F/CDH23/SHOC2/BRK1/RAF1/TCF7L1	0.732303308435474
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/1682	24/9376	1.3935790725327	EXTL3/EXT2/EXT1/B3GALT6/NDST1/HS2ST1	0.902626152871801
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/1682	85/9376	1.18044344967476	ENPP1/ENTPD1/DCTD/NME3/NT5E/GDA/ENTPD8/AMPD2/UPP1/NME4/ENTPD4/TK2/CMPK2/RRM2B/UCK1/NT5C2/AK9/LACC1	0.781343308218177
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	21/1682	102/9376	1.14765335385046	ADCY7/ATP1B1/SLC4A2/GNAQ/ITPR2/CTRB2/ADCY3/PRKCA/ATP1A2/RAB27B/CPA1/ITPR1/RAP1A/PLCB2/PRKCB/KCNMA1/CD38/CPB1/TRPC1/ADCY1/RAP1B	0.70102321327224
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1682	56/9376	1.19449634788517	MAN1A1/MGAT5/MGAT2/MGAT4A/B4GALT2/DHRSX/MAN1C1/MGAT1/MGAT4B/FUT8/ST6GAL2/ALG5	0.682527337703129
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	17/1682	83/9376	1.14172743291836	NFKBIA/IFI16/CASP1/SAMHD1/PYCARD/ZDHHC1/NFKB1/IL18/AIM2/ADAR/IL1B/CCL5/POLR3D/PCBP1/ZCCHC3/TREX1/NLRP3	0.606369769504389
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	16/1682	78/9376	1.14344949541145	PLCD3/PIK3CA/IPMK/CDIPT/INPP5D/INPPL1/PLCB2/SACM1L/INPP1/INPP5B/PLCG2/PIK3CD/PI4KA/MTMR1/ITPKA/PI4K2A	0.594804298374719
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1682	37/9376	1.2052575762445	HK3/GMDS/GFPT2/UGDH/GCK/PGM3/GFPT1/GNE	0.58488759924219
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/1682	144/9376	1.0838948341921	ATXN1/VLDLR/PIK3R1/RBPJ/RB1CC1/MAP3K5/AKT3/GNAQ/ULK2/ITPR2/PIK3CA/PRKCA/MAPK8/ATXN2L/PPIF/ITPR1/PUM2/ATXN2/ERN1/PLCB2/BEAN1/PRKCB/CACNA1A/SP1/ATXN1L/PIK3CD/CIC/ULK1	0.474341487472144
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1682	43/9376	1.16671736305063	ACSL5/CPT1A/ACOX1/ACSL3/ADH1B/ACSL1/ALDH9A1/ACADM/ACADVL	0.512303084031418
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/1682	17/9376	1.31160383297195	GGT5/FMO1/ADO/GGT7	0.601222286871939
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1682	12/9376	1.3935790725327	CD46/ASGR1/NPC1	0.637843980650827
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1682	18/9376	1.2387369533624	ACSL5/ACSL3/ACSL1/FASN	0.474009365306193
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1682	18/9376	1.2387369533624	LMBRD1/ABCD4/TCN2/ZNF76	0.474009365306193
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1682	29/9376	1.15330681864775	TEAD1/YAP1/RASSF2/RASSF4/DCHS1/RASSF1	0.386586685206155
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/1682	149/9376	1.04752252431988	ADCY7/MAPK3/MGLL/SLC17A8/MT-ND4L/GNAI2/MAPK1/MT-ND2/GNAQ/DAGLB/ITPR2/ADCY3/PRKCA/MAPK8/ITPR1/MT-ND3/MAPK14/PRKACB/GNG12/PLCB2/PRKCB/CACNA1A/CACNA1C/PTGS2/GNGT2/NDUFS1/ADCY1/PRKACA	0.273391443746348
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/1682	78/9376	1.07198390194823	FN1/CLTB/PIK3R1/ITGB1/PTK2/PIK3CA/SHC2/CLTC/BCAR1/WASF2/MAD2L2/WASL/PIK3CD/DNM1/HCLS1	0.298476715932564
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	24/1682	128/9376	1.04518430439952	ENPP1/PAPSS2/ADCY7/PDE10A/ENTPD1/NME3/PDE3A/NT5E/GDA/ENTPD8/ADCY3/AMPD2/NME4/ENTPD4/PDE4B/NUDT9/RRM2B/GUCY1A2/PDE7B/NT5C2/PDE3B/AK9/ADCY1/LACC1	0.240652965673318
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	71/1682	388/9376	1.02004241391569	APOE/WNT2/LPL/RTN4/PIK3R1/FZD2/MAPK3/CSF1/LRP1/SLC39A13/CAPN2/WNT2B/TNFRSF1A/TUBB2A/TUBA1A/IRS2/ADAM10/RB1CC1/FZD1/IRS1/MAP3K5/MT-ND4L/MAPK1/AKT3/FAS/MT-ND2/GNAQ/ULK2/ITPR2/NFKB1/PIK3CA/WNT5B/ATF4/SLC39A11/MAPK8/CYBB/IL1B/PPIF/CSNK2A2/MME/ITPR1/WNT4/MT-ND3/MAP2K1/SLC39A8/KLC4/BID/BACE1/ERN1/FRAT1/PLCB2/CSNK1A1/FZD7/NCSTN/COX7A1/SLC39A9/SLC39A6/CACNA1C/WNT9A/PTGS2/CHRM5/TUBA4A/PIK3CD/CALM2/ULK1/KLC1/BACE2/SLC39A14/RTN3/NDUFS1/RAF1	0.188519769811619
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	29/1682	157/9376	1.02965077970569	PRKAG2/FOS/MLXIP/PIK3R1/IL6R/JUN/TNFRSF1A/IRS2/IRS1/MAP3K5/AKT3/FAS/NFKB1/PIK3CA/ATF4/MAPK8/IL1B/MAPK14/SREBF1/CEBPA/BID/ERN1/RXRA/BCL2L11/COX7A1/PPARA/PIK3CD/NDUFS1/BAX	0.175172762877776
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	29/1682	158/9376	1.02313400261894	CDKN1A/CCND2/GADD45B/TGFB2/SMAD3/CREBBP/ANAPC13/SMAD4/ANAPC16/RBL2/ABL1/NIPBL/CDK6/YWHAG/PPP2CB/CDKN2A/MAU2/RB1/GADD45A/ATM/PDS5A/PPP2R5E/EP300/TGFB3/CDKN2B/CDC14A/CDC25B/MAD2L2/STAG1	0.137114541242739
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1682	48/9376	1.04518430439952	PIK3R1/ATP1B1/HK3/AKT3/PIK3CA/ATP1A2/PLCB2/PRKCB/PIK3CD	0.146735938386656
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/1682	37/9376	1.05460037921393	GLUL/IL4I1/GFPT2/GLS/GFPT1/DDO/AGXT	0.155585412730935
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1682	32/9376	1.04518430439952	GALM/GAA/HK3/B4GALT2/GCK/GLB1	0.119706771508864
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1682	83/9376	1.00740655845737	ACSL5/PIPOX/ACOX1/ACSL3/SOD2/PEX2/PEX6/ACSL1/ABCD4/DECR2/MLYCD/ACOX2/DHRS4/DDO/AGXT	0.0316883827791135
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1682	21/9376	1.06177453145348	ENPP1/DPYD/PANK3/BCAT1	0.132501182598227
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	21/1682	117/9376	1.00051830848501	MORF4L2/SMARCA1/BAZ2B/SMARCD3/MBD3/RSF1/BRD7/CHD4/EPC1/EPC2/BCL7C/GATAD2B/SMARCC2/PBRM1/CHD3/PHF6/DPF2/SRCAP/BPTF/SMARCD2/MBD2	0.00263767783768678
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	13/1682	72/9376	1.00647377460695	NFKBIA/CYLD/NFKB1/TBKBP1/ADAR/MAPK8/IFIH1/MAPK14/ZNFX1/TRADD/TRIM25/RNF125/NLRX1	0.0257816978934787
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1682	10/9376	1.11486325802616	PAPSS2/TST	0.169912995673071
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1682	16/9376	1.04518430439952	IL4I1/MAOA/ALDH3B1	0.0845730923886217
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1682	28/9376	0.995413623237642	ATP6V0E1/ATP6V0D1/ATP6V1G1/ATP6V0A1/ATP6V1B2	-0.0113634952593092
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	18/1682	104/9376	0.964785511753407	PLD3/LPCAT2/SGMS2/PLD1/LPIN2/GDPD5/PLA2G15/DGKH/CHKB/CDIPT/SGMS1/GPAM/AGPAT4/PGS1/PCYT2/GPAT2/GPCPD1/LCAT	-0.168839432025164
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1682	17/9376	0.983702874728964	PAPSS2/INMT/SEPHS2	-0.031444397944144
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1682	47/9376	0.948819794064817	ACYP2/ADH1B/ME3/ACSS1/HAGH/ME1/ALDH9A1/ME2	-0.164458359738133
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1682	30/9376	0.929052715021799	PIGT/PIGP/MPPE1/B3GALT4/PGAP3	-0.181972626043887
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1682	42/9376	0.929052715021799	AOC1/IL4I1/INMT/MAOA/HAAO/TDO2/ALDH9A1	-0.215451275906525
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	24/1682	143/9376	0.935549587154819	HLA-DRA/HLA-DPA1/HLA-DPB1/FCGR3A/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-DQB1/HLA-DMA/HLA-DRB1/C1QA/C2/IL10/C1QB/C7/CD86/C1QC/FCGR1A/FCGR2A/HLA-DOA/C3/CD40/HLA-DRB5/C1R	-0.363115550048261
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1682	31/9376	0.899083272601741	DPYD/ACOX1/ALDH3B1/MLYCD/ALDH9A1	-0.263133956257787
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	23/1682	138/9376	0.929052715021799	ADCY7/MAPK3/ANAPC13/CPEB2/CAMK2D/CAMK2G/MAPK1/ANAPC16/ITPR2/ADCY3/YWHAG/PPP2CB/ITPR1/MAPK14/MAP2K1/PPP2R5E/PRKACB/RPS6KA3/MAD2L2/CALM2/RPS6KA2/ADCY1/PRKACA	-0.39256256951505
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1682	32/9376	0.870986920332937	GABARAPL2/GABARAPL1/GABARAP/ULK2/PPP2CB	-0.341794334439782
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	38/1682	227/9376	0.933145458259781	GSTT1/HGF/NCF2/FOS/NFKBIA/PIK3R1/MAPK3/VEGFA/PLD1/JUN/FOXO3/AHR/MAP3K5/MT-ND4L/PTK2/NFE2L2/MAPK1/AKT3/MT-ND2/NFKB1/PDPK1/PIK3CA/ABL1/MAPK8/SOS1/EGFR/PPIF/MT-ND3/MAPK14/MAP2K1/SOD2/COX7A1/HMOX1/ABL2/GSTO1/PIK3CD/NDUFS1/RAF1	-0.476737784610796
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1682	26/9376	0.857587121558584	SCARB1/LMBRD1/ABCD4/TCN2	-0.339979457028586
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/1682	20/9376	0.836147443519619	LIPA/SOAT1/CYP24A1	-0.342961725866043
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	81/1682	480/9376	0.940665873959572	ATXN1/WNT2/SQSTM1/HIP1/PINK1/FZD2/MAPK3/CSF1/DNAH11/CAPN2/WNT2B/MAP1LC3B/PRNP/TNFRSF1A/TUBB2A/TUBA1A/UBB/RAB5A/RB1CC1/FZD1/GPX7/MAP3K5/MT-ND4L/CAMK2D/CAMK2G/MAPK1/FAS/MAP2K3/MT-ND2/GNAQ/OPTN/ULK2/ITPR2/NFKB1/PRKCA/WNT5B/ATF4/UBE2L6/UBC/MAPK8/CYBB/IL1B/ATXN2L/PPIF/BCL2/CSNK2A2/LRRK2/ITPR1/WNT4/UBA7/MT-ND3/MAPK14/ATXN2/MAP2K1/C9orf72/KLC4/BID/ERN1/FRAT1/PLCB2/CSNK1A1/BDNF/FZD7/COX7A1/PRKCB/ATXN1L/CACNA1C/WNT9A/PTGS2/CHRM5/TUBA4A/RAB1A/CALM2/ULK1/UCHL1/KLC1/TNFRSF1B/NDUFS1/SPG11/RAF1/BAX	-0.623950769048933
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1682	65/9376	0.857587121558584	LPL/MGLL/LPIN2/PNPLA3/GK/DGKH/GPAM/AGPAT4/GPAT2/ALDH9A1	-0.538679343798197
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1682	28/9376	0.796330898590114	B3GNT3/B4GALT2/B3GALT2/ST3GAL6	-0.504623363552295
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1682	35/9376	0.796330898590114	FBP1/HK3/PFKFB3/GMDS/HSD17B14	-0.564397428509518
NA	NA	hsa04082	Neuroactive ligand signaling	32/1682	199/9376	0.896372468764751	SLC6A2/ADCY7/P2RX4/SLC18A3/TAC3/SLC17A8/SLC1A3/GNAI2/GNAQ/HTR2B/ADCY3/PRKCA/POMC/P2RX6/PRKACB/P2RY11/ADORA2B/GNG12/AGRP/GABBR1/PLCB2/GNA11/PRKCB/SLC6A4/P2RY14/CHRM5/ADORA1/GNGT2/P2RX1/ADCY1/ADRB2/PRKACA	-0.690834260208676
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1682	61/9376	0.822440108379954	FTL/ATP1B1/CYBRD1/SLC40A1/VDR/MT1G/ATP1A2/TRPM7/HMOX1	-0.650490415750991
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1682	23/9376	0.727084733495321	ATP1B1/ATP1A2/GLS	-0.612687223468854
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1682	30/9376	0.743242172017439	ABCC3/NFKB1/IL1B/MTHFR	-0.658557917045979
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1682	37/9376	0.75328598515281	IL4I1/MAOA/COMT/ALDH3B1/ADH1B	-0.703018960291576
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1682	63/9376	0.796330898590114	HPGD/PTGES/TBXAS1/ALOX5/GGT5/PTGIS/PTGS2/LTC4S/PTGS1	-0.75835606337265
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	44/1682	275/9376	0.891890606420928	CREB5/NCF2/CREB3L1/PIK3R1/MAPK3/C1QA/C1QB/C7/PRNP/C1QC/RAC2/TUBB2A/TUBA1A/HSPA1B/HSPA1A/MT-ND4L/MAPK1/MT-ND2/ITPR2/PIK3CA/ATF4/LAMC1/MAPK8/CYBB/IL1B/CREB3L2/PPIF/CSNK2A2/ITPR1/MT-ND3/MAPK14/CCL5/PRKACB/KLC4/ATF6B/COX7A1/CACNA1C/TUBA4A/PIK3CD/HSPA6/KLC1/NDUFS1/BAX/PRKACA	-0.850761373911663
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1682	57/9376	0.782360181070989	ACSL5/CPT1A/ACOX1/ACSL3/ACSL1/ACADM/ACADVL/FASN	-0.770572792524385
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1682	31/9376	0.719266618081393	UGDH/GUSB/ALDH9A1/HSD17B14	-0.731994460604615
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1682	31/9376	0.719266618081393	GLUL/HYI/ACSS1/AGXT	-0.731994460604615
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1682	51/9376	0.765102235900305	ENPP2/PLD3/LPCAT2/PLA2G7/PLD1/GDPD3/TMEM86A	-0.786433660529757
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	37/1682	235/9376	0.877658309509955	CREB5/PRKAG2/ACSL5/CREB3L1/ADCY7/RHEB/MGLL/CPT1A/MAP3K5/SMARCD3/MT-ND4L/ACSL3/PRKG1/MAP2K3/MT-ND2/ADCY3/COX14/ADRB3/SOS1/CREB3L2/MT-ND3/MAPK14/PRKACB/RPS6KA3/FRS2/TSC2/SLC25A20/FGFR1/ACSL1/COX7A1/SMARCC2/RPS6KA2/SMARCD2/NDUFS1/ADCY1/SIRT6/PRKACA	-0.888043207550971
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1682	45/9376	0.743242172017439	ABCA1/ABCG1/ABCC3/ABCA8/ABCD4/ABCA9	-0.807213466094499
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1682	41/9376	0.679794669528146	SDS/PIPOX/MAOA/SDSL/AGXT	-0.960695745762937
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/1682	34/9376	0.655801916485976	PRKAG2/PER1/CLOCK/CRY1	-0.94004905645992
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/1682	268/9376	0.852787193639413	DUSP1/PINK1/SLC39A13/MAOA/TUBB2A/TUBA1A/UBB/MAP3K5/MT-ND4L/CAMK2D/GNAI2/CAMK2G/NFE2L2/MT-ND2/ITPR2/ATF4/UBE2L6/SLC39A11/UBC/MAPK8/PPIF/LRRK2/ITPR1/UBA7/MT-ND3/PRKACB/SLC39A8/KLC4/ERN1/COX7A1/SLC39A9/SLC39A6/TUBA4A/CALM2/UCHL1/KLC1/SLC39A14/NDUFS1/TXN/BAX/PRKACA	-1.1432047515153
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/1682	82/9376	0.74777413648096	GSTT1/DPYD/NME3/UPP1/NME4/GUSB/CES2/TK2/RRM2B/UCK1/GSTO1	-1.07255050728606
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/1682	63/9376	0.707849687635657	POLD4/XPC/DDB1/POLR2B/ERCC1/DDB2/XPA/UVSSA	-1.08781331711104
Human Diseases	Substance dependence	hsa05034	Alcoholism	28/1682	191/9376	0.817177257191949	CREB5/CREB3L1/FOSB/MAPK3/MAOA/GNAI2/MAPK1/ATF4/SHC2/SOS1/CREB3L2/CAMKK1/MAP2K1/PRKACB/ADORA2B/GNG12/SLC29A3/ATF6B/BDNF/CRH/HDAC7/GNGT2/CALM2/CAMKK2/HDAC4/RAF1/HDAC9/PRKACA	-1.19352045478592
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/1682	90/9376	0.743242172017439	ADCY7/SCARB1/AQP9/ATP1B1/ABCC3/SLC4A2/ADCY3/ATP1A2/PRKACB/RXRA/ADCY1/PRKACA	-1.14433492074626
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1682	50/9376	0.668917954815695	AOC1/SAT1/MAOA/OAT/ALDH9A1/PYCR1	-1.09747710465466
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1682	36/9376	0.6193684766812	UGDH/GUSB/FGGY/CRYL1	-1.06980619448793
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1682	36/9376	0.6193684766812	ENPP1/GAA/HK3/GCK	-1.06980619448793
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/1682	59/9376	0.661359559846027	GSTT1/GPX7/GGT5/ANPEP/RRM2B/GSTO1/GGT7	-1.21997047698112
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/1682	67/9376	0.665590004791737	FBP1/GALM/HK3/GCK/ALDH3B1/ADH1B/ACSS1/ALDH9A1	-1.2843626831892
NA	NA	hsa04981	Folate transport and metabolism	3/1682	31/9376	0.539449963561045	ABCC3/SLCO2B1/MTHFR	-1.20085496495144
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1682	23/9376	0.484723155663548	GLUL/GLS	-1.15678226109378
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1682	23/9376	0.484723155663548	B4GALT2/POMGNT2	-1.15678226109378
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1682	68/9376	0.655801916485976	CYP2W1/RDH10/ALDH1A1/DHRS4L2/ADH1B/CYP26A1/DHRS4/HSD17B6	-1.331855964143
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/1682	54/9376	0.6193684766812	SDS/IL4I1/SDSL/TST/BCAT1/LACC1	-1.31150402145336
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1682	54/9376	0.6193684766812	HES1/REV1/WDR48/ERCC1/REV3L/POLK	-1.31150402145336
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1682	32/9376	0.522592152199762	ACOX1/ACSS1/MLYCD	-1.26479654633707
Cellular Processes	Cell motility	hsa04814	Motor proteins	27/1682	194/9376	0.77580690635841	TNNI3/DYNLT1/DNAH11/KIF21A/TUBB2A/TNNI2/TUBA1A/MYO7B/DYNC1LI2/TNNT3/MYO1D/KIF12/MYO9B/MYO5A/MYO9A/MYO1C/KLC4/DYNC1H1/MYO1G/DYNLT3/KIF1B/TUBA4A/KLC1/MYO1F/MYO15B/DYNLRB1/DYNC2H1	-1.47528862392231
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1682	15/9376	0.37162108600872	ALPP	-1.13875069015654
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1682	33/9376	0.506756026375527	BCAT1/OGDH/AGXT	-1.32708312345811
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/1682	78/9376	0.643190341168938	PABPC1/CNOT1/XRN1/TOB1/PABPC4L/DCP1B/CNOT6L/CNOT4/LSM1	-1.47948877872037
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/1682	34/9376	0.491851437364482	CRCP/POLR3D/POLR2B	-1.38781881633435
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1682	26/9376	0.428793560779292	HES1/GCK	-1.36362987099777
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1682	43/9376	0.518541050244725	ABCA1/SCARB1/CD36/SLC27A1	-1.47946740687859
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1682	17/9376	0.327900958242988	GLUL	-1.29677776757631
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/1682	46/9376	0.484723155663548	FTL/GUSB/HMOX1/BLVRA	-1.63795234961539
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1682	29/9376	0.384435606215917	RCVRN/CALM2	-1.5522401457609
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1682	19/9376	0.293385067901621	OGDH	-1.44149732013825
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/1682	48/9376	0.4645263575109	IL4I1/BCAT1/ALDH9A1/ACADM	-1.73894958561731
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	52/1682	370/9376	0.783417424558923	PRLR/CSH1/FPR3/C5AR1/P2RX4/PTGER3/PGRMC1/NR3C1/TAC3/ADM/C3AR1/P2RX7/PTGER2/PTAFR/PTGER4/PTGIR/C3/GPR35/HTR2B/VIPR2/TSPO/LPAR1/CYSLTR2/POMC/FPR1/CSHL1/ADRB3/NPY1R/GLP2R/THRB/LYPD6/P2RX6/TBXA2R/P2RY11/ADORA2B/S1PR4/NPW/GABBR1/NPFFR2/CSH2/CRH/S1PR3/P2RY14/CHRM5/S1PR5/ADORA1/THRA/P2RX1/PTGFR/LPAR2/EDNRB/ADRB2	-1.98738014827449
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/1682	87/9376	0.576653409323876	TNNI3/ATP1B1/ATP1A2/CACNA2D1/CACNA2D4/COX7A1/CACNA1C/CACNB1/CACNB2	-1.85478576631535
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	13/1682	116/9376	0.624707860100865	FBP1/SDS/H6PD/SDSL/HK3/ACOX1/GCK/ME3/ACSS1/ME1/ME2/OGDH/AGXT	-1.90158399263478
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1682	31/9376	0.359633309040697	FBP1/H6PD	-1.66971546929827
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1682	66/9376	0.506756026375527	HSD17B2/HSD3B2/COMT/HSD17B1/HSD17B6/HSD11B1L	-1.88010220187433
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1682	23/9376	0.242361577831774	PCYOX1	-1.70087729871871
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1682	23/9376	0.242361577831774	POLD4	-1.70087729871871
NA	NA	hsa04382	Cornified envelope formation	27/1682	217/9376	0.693578524578486	COL17A1/TJP1/S100A4/DST/SLC27A1/LAMA5/COL4A2/S100A13/S100A10/S100A16/LAMA3/PKP1/PPP2CB/KRT14/UGCG/PPL/PPP2R5E/COL4A4/S100A2/COL4A1/CLDN11/CLDN19/ST14/CLDN23/PKP2/LAMB3/SPTLC2	-2.13524434197549
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/1682	44/9376	0.380067019781645	MPG/POLD4/PARP4	-1.92710890127333
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/1682	46/9376	0.363542366747661	PSMB8/PSMB9/PSMB10	-2.02315956417328
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1682	26/9376	0.214396780389646	ACOX1	-1.87545507798236
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1682	73/9376	0.458162982750476	GSTT1/MAOA/FMO1/ALDH3B1/ADH1B/GSTO1	-2.17290697694744
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/1682	27/9376	0.206456158893733	ACOX1	-1.93060208312489
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	39/1682	308/9376	0.705838751023055	CREB5/CLTB/CREB3L1/HIP1/DNAH11/CREBBP/TUBB2A/TUBA1A/SLC1A3/RB1CC1/GPX7/MAP3K5/MT-ND4L/MT-ND2/GNAQ/ULK2/CLTC/BBC3/AP2A2/MAPK8/CREB3L2/PPIF/ITPR1/MT-ND3/SOD2/KLC4/ERN1/EP300/PLCB2/BDNF/AP2B1/COX7A1/POLR2B/SP1/TUBA4A/ULK1/KLC1/NDUFS1/BAX	-2.45429976784569
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/1682	28/9376	0.199082724647528	ALPP	-1.98440296843125
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/1682	86/9376	0.453723418964135	PRKACB/GABBR1/PLCB2/PKD2L1/CACNA1A/CACNA1C/PRKACA	-2.37944951195341
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/1682	41/9376	0.271917867811258	POLD4/ATM	-2.18442774181492
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1682	41/9376	0.271917867811258	SLC17A8/CACNA1A	-2.18442774181492
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1682	70/9376	0.398165449295057	GSTT1/SULT1A1/GSTO1/PTGS2/HSD11B1L	-2.36301868309662
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/1682	103/9376	0.48707618069104	PABPC1/PPP2CB/PABPC4L/PPP2R5E/SYMPK/DDX19A/MSI2/SMG1/PCF11	-2.44728130633726
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1682	30/9376	0.18581054300436	OGDH	-2.08831379005225
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/1682	31/9376	0.179816654520348	SEC62	-2.1385759736451
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/1682	44/9376	0.253378013187763	GTF2I/TAF7	-2.32093133061811
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	13/1682	138/9376	0.525116751968843	ATP6V0E1/ATP6V0D1/ATP6V1G1/MT-ND4L/MT-ND2/LHPP/ATP6AP1/MT-ND3/ATP6V0A1/COX7A1/ATP6V1B2/ATP6V1H/NDUFS1	-2.62760425749969
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/1682	75/9376	0.37162108600872	SDS/GLUL/SDSL/BCAT1/PYCR1	-2.55452381482001
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1682	36/9376	0.1548421191703	POLD4	-2.37540792299176
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1682	79/9376	0.352804828489291	GSTT1/ALDH3B1/ADH1B/GSTO1/HSD11B1L	-2.70084674522183
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	14/1682	154/9376	0.506756026375527	QPRT/NME3/HAAO/NMNAT2/UGDH/TDO2/NME4/GUSB/PANK3/BCAT1/CMPK2/ALPP/HSD17B6/AK9	-2.88557344221986
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	44/1682	368/9376	0.666494339037378	SQSTM1/PINK1/DNAH11/MAP1LC3B/CASP1/TNFRSF1A/TUBB2A/TUBA1A/RAB5A/RB1CC1/GPX7/MAP3K5/MT-ND4L/MAP2K3/MT-ND2/OPTN/ULK2/ATF4/PFN2/NUP214/ATXN2L/BCL2/MT-ND3/MAPK14/ANG/UBQLN4/ATXN2/C9orf72/KLC4/BID/ERN1/POM121/COX7A1/RANBP2/SETX/TUBA4A/RAB1A/ULK1/KLC1/POM121C/TNFRSF1B/NDUFS1/SPG11/BAX	-3.05165528121296
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/1682	108/9376	0.412912317787466	EEF1A1/NUP214/POM121/RANBP2/DDX19A/TNPO1/POM121C/XPOT	-2.86909135314791
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/1682	39/9376	0.142931186926431	MTHFR	-2.50764964627892
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/1682	183/9376	0.213225213283692	RPP25/SBDS/REXO2/XRN1/CSNK2A2/SNORD3D/SNORD3B-1	-5.02539139359634
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/1682	243/9376	0.137637439262489	HSPA1B/HSPA1A/DDX5/PCBP1/SNRNP200/HSPA6	-6.36808489344542
Genetic Information Processing	Translation	hsa03010	Ribosome	1/1682	222/9376	0.025109532838427	RPS4Y1	-6.87304836239005
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	12/1682	449/9376	0.148979499958952	RGS2/ARRB2/NCALD/PRKG1/CAMK2D/CAMK2G/ADCY3/PRKACB/ANO2/ARRB1/CALM2/PRKACA	-8.64038248529175