category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	34/314	238/9376	4.26569608735214	RPS4Y1/RPS15A/NFKBIA/RPS20/RPS12/RPL34/RPS11/RPL13A/MAPK3/RPLP1/RPL10A/C1QB/RPS28/C1QA/RPL31/RPS8/RPS10/RPS29/RPS27L/RPL27A/UBA52/RPL30/RPL10/RPL41/RPL9/RPS16/IL6ST/RPL26/RPS25/IL1B/RPLP2/RPL36A/RPL17/FAU	9.49898279134184
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/314	82/9376	6.9187509709492	HLA-DRA/CD74/HLA-B/CTSB/HLA-DPA1/HLA-DRB1/LGMN/HLA-DPB1/CTSS/HLA-A/HLA-DQB1/TAPBP/HLA-DQA1/HLA-DMA/HLA-DMB/CTSL/B2M/TAPBPL/PSME1	10.0201470036106
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	20/314	95/9376	6.28628897083473	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/ATP6V0E1/CXCL2/CCL3/ATP6V0D1/HLA-DQB1/HLA-DQA1/ITGB2/CXCL3/HLA-DMA/HLA-DMB/ACP5/CCL20/ATP6V1G1/CTSL/IL1B/TNFSF13B	9.63948317037228
Genetic Information Processing	Translation	hsa03010	Ribosome	28/314	222/9376	3.76611005910369	RPS4Y1/RPS15A/RPS20/RPS12/RPL34/RPS11/RPL13A/RPLP1/RPL10A/RPS28/RPL31/RPS8/RPS10/RPS29/RPS27L/RPL27A/UBA52/RPL30/RPL10/RPL41/RPL9/RPS16/RPL26/RPS25/RPLP2/RPL36A/RPL17/FAU	7.76388193546019
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	22/314	155/9376	4.23817546743374	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/TUBB2A/ATP6V0E1/HLA-A/ATP6V0D1/OLR1/HLA-DQB1/HLA-DQA1/ITGB2/MSR1/HLA-DMA/HLA-DMB/FCGR3A/ATP6V1G1/CTSL/SCARB1/RAB5C	7.56685914229298
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	15/314	78/9376	5.74228319451249	HLA-DRA/EEF1A1/HLA-DPA1/HLA-DRB1/NFKBIA/HLA-DPB1/MAPK3/HLA-DQB1/HLA-DQA1/ITGB2/IFNGR2/HLA-DMA/HLA-DMB/FCGR3A/IL1B	7.82849807066034
Human Diseases	Immune disease	hsa05310	Asthma	10/314	32/9376	9.3312101910828	PRG2/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/FCER1G/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB	8.78729282972881
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/314	44/9376	7.46496815286624	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/IL1B	8.0009912661768
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/314	45/9376	7.29907997169144	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/IL1B	7.88420154309136
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	26/314	250/9376	3.10542675159236	CTSD/CLTB/CTSB/VAMP8/LGMN/CTSS/HEXB/LAPTM5/ATP6V0E1/CD68/CTSZ/ASAH1/PSAP/LAPTM4A/ATP6V0D1/CTSA/CTSH/NPC2/LIPA/ACP5/GAA/ATP6V1G1/CTSL/AP3S1/HEXA/SLC15A3	6.28070423096779
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/314	39/9376	7.65637759268332	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB	7.75362883198961
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	24/314	224/9376	3.1992720655141	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/NFKBIA/HLA-DPB1/HLA-A/MAPK3/CDKN2A/ANAPC13/HLA-DQB1/HLA-DQA1/ITGB2/TSPO/HLA-DMA/HLA-DMB/IL1R2/ZFP36/ANAPC16/SPI1/CREB5/B2M/CDKN1A/ETS2	6.20130932481699
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/314	181/9376	3.46440510961748	HLA-DRA/CD74/CTSD/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/FCER1G/MAPK3/ATP6V0D1/HLA-DQB1/HLA-DQA1/ITGB2/IFNGR2/HLA-DMA/HLA-DMB/FCGR3A/IL1B/LSP1/TRADD/RAB5C	6.23180642358224
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/314	180/9376	3.31776362349611	HLA-DRA/CD74/HLA-B/HLA-DPA1/HLA-DRB1/NFKBIA/HLA-DPB1/BST2/HLA-A/HLA-DQB1/TAPBP/HLA-DQA1/RHEB/IFNGR2/HLA-DMA/HLA-DMB/IL1B/TRADD/B2M/TAPBPL	5.84445941349341
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/314	100/9376	4.1803821656051	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/CD59/HLA-DQB1/HLA-DQA1/CSF2RA/HLA-DMA/HLA-DMB/IL1B/IL1R2/CD37/CD44	5.95164985098513
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/314	54/9376	5.52960603916018	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB	6.21356999517382
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/314	66/9376	4.97664543524416	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/IFNGR2/HLA-DMA/HLA-DMB/IL1B/STAT4	6.03465478081153
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/314	109/9376	3.83521299596798	HLA-DRA/EBI3/HLA-DPA1/HLA-DRB1/NFKBIA/HLA-DPB1/MAPK3/HLA-DQB1/HLA-DQA1/IFNGR2/HLA-DMA/HLA-DMB/IL6ST/IL1B	5.54201620954665
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/314	70/9376	4.69226569608735	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/HLA-DMB	5.77163521579401
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/314	99/9376	3.92099337322267	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/C1QB/C1QA/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/KRT14/HLA-DMB/FCGR3A	5.43854622301113
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/314	50/9376	5.37477707006369	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/TNFSF13B	5.77340012206991
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	19/314	205/9376	2.76750038837968	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/NFKBIA/HLA-DPB1/VIM/HLA-A/HLA-DQB1/TAPBP/HLA-DQA1/HLA-DMA/HLA-DMB/GADD45B/TRADD/B2M/CDKN1A/TAPBPL/CD44	4.76284595160754
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/314	93/9376	3.85288678857612	HLA-DRA/HLA-DPA1/HLA-DRB1/NFKBIA/HLA-DPB1/MAPK3/HLA-DQB1/HLA-DQA1/IFNGR2/HLA-DMA/HLA-DMB/STAT4	5.14659827623539
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/314	160/9376	2.9859872611465	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/ESAM/CLDN19/HLA-A/HLA-DQB1/HLA-DQA1/ITGB2/JAM2/HLA-DMA/HLA-DMB/MAG/PTPRF	4.71632419138385
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/314	112/9376	3.46587807097361	HLA-DRA/HLA-DPA1/HLA-DRB1/NFKBIA/HLA-DPB1/MAPK3/HLA-DQB1/HLA-DQA1/IFNGR2/HLA-DMA/HLA-DMB/LY96/GNAI2	4.8867460423214
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/314	137/9376	3.05137384350737	CTSD/CTSB/TNFSF10/NFKBIA/CTSS/MAPK3/CTSZ/ENDOG/CTSH/GADD45B/BCL2A1/CTSL/CSF2RB/TRADD	4.5022649307173
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/314	52/9376	4.59382655561	APOE/APOC1/TSPO/NPC2/LIPA/LPL/SCARB1/CYP27A1	4.8372227436538
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	22/314	298/9376	2.20442012567862	CSH1/EBI3/CSH2/TNFSF10/GDF15/CXCL2/INHA/CCL3/TNFRSF12A/CXCL3/CSF2RA/IFNGR2/IL6ST/CCL20/IL1B/IL1R2/CSF2RB/CCL4/TNFSF13B/CXCL16/IL1RN/GH2	3.93305011330314
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	15/314	169/9376	2.65028455131346	CTSD/CTSB/VAMP8/GABARAPL2/MAPK3/MAP1LC3B/UBA52/RHEB/SQSTM1/GABARAPL1/OPTN/GABARAP/CTSL/RRAS/WIPI1	4.02978195873557
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/314	105/9376	3.1281771307249	GABARAPL2/MAP1LC3B/FIS1/UBA52/SQSTM1/GABARAPL1/OPTN/GABARAP/PINK1/RRAS/RAB5C	4.08204289708744
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/314	94/9376	3.17658219270904	NFKBIA/CXCL2/MAPK3/JUND/MMP9/CXCL3/S100A9/CCL20/IL1B/TRADD	3.94781369996402
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	18/314	248/9376	2.16724881857407	TNFSF10/NFKBIA/TUBB2A/DYNLT1/MAPK3/ARPC1B/ARPC2/SKP1/DYNLRB1/S100A10/PKN1/IL1B/TXN/TRADD/RRAS/LY96/RHOB/RAB5C	3.46768708564659
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/314	173/9376	2.41640587607231	HLA-DRA/HLA-DPA1/TNFSF10/HLA-DRB1/NFKBIA/HLA-DPB1/MAPK3/HLA-DQB1/HLA-DQA1/IFNGR2/HLA-DMA/HLA-DMB/IL1B/TRADD	3.50013256829233
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/314	103/9376	2.89901675839466	FN1/HSPB1/PRDX1/CXCL2/ITGB2/CXCL3/IL1B/IL1R2/COL4A1/RAB5C	3.60724560609424
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/314	71/9376	3.36449268861577	NFKBIA/ATP6V0E1/CXCL2/ATP6V0D1/JAM2/CXCL3/ATP6V1G1/TJP1	3.72260875485511
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/314	42/9376	4.26569608735214	FTL/FTH1/GPX4/SAT1/MAP1LC3B/HMOX1	3.9482527464931
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/314	105/9376	2.84379739156809	NFKBIA/CXCL2/CXCL3/GADD45B/BCL2A1/IL1B/TRADD/CCL4/LY96/TNFSF13B	3.53657594438824
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	12/314	142/9376	2.52336951646183	TYROBP/NFKBIA/MAPK3/TREM2/JUND/IFNGR2/SQSTM1/FCGR3A/ACP5/IL1B/SPI1/FHL2	3.4048103875792
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	16/314	227/9376	2.10466062459665	HLA-B/NFKBIA/HLA-A/MAPK3/CDKN2A/CCL3/TAPBP/RHEB/IL1B/TRADD/CCL4/CREB5/B2M/CDKN1A/TAPBPL/GNAI2	3.1361254155612
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/314	78/9376	3.06255103707333	SERPING1/MAPK3/C1QB/C1QA/ITGB2/IL1B/LY96/GNAI2	3.40483183987221
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/314	133/9376	2.4696135242565	TYROBP/HLA-B/TNFSF10/FCER1G/HLA-A/MAPK3/ITGB2/IFNGR2/FCGR3A/VAV3/HCST	3.17731971284958
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/314	103/9376	2.60911508255519	SERPINE1/NFKBIA/MAPK3/C1QB/C1QA/CCL3/IFNGR2/IL1B/GNAI2	3.05656771357512
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	11/314	143/9376	2.296913277805	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/C1QB/C1QA/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/FCGR3A	2.90901506839059
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/314	88/9376	2.71453387376954	SERPINE1/SERPINE2/SERPING1/CD59/C1QB/C1QA/ITGB2/SERPINA1	3.00790929566136
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/314	56/9376	3.1992720655141	EEF1A1/NFKBIA/CXCL2/ITGB2/CXCL3/IL1B	3.07258176378316
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/314	41/9376	3.64144787944695	GCSH/PIPOX/SDS/MAOA/BPGM	3.15511538404338
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/314	15/9376	5.97197452229299	HEXB/HEXA/ST3GAL5	3.58716897489919
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	10/314	133/9376	2.24510320386955	TNFSF10/PRKAG2/GABARAPL2/MAPK3/HOMER3/GABARAPL1/GADD45B/GABARAP/FBXO32/CDKN1A	2.69192606688097
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/314	61/9376	2.93703665030803	FTL/FTH1/MT1X/HMOX1/MT1F/ATOX1	2.82520365353073
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/314	119/9376	2.25830969330407	NFKBIA/CXCL2/MAPK3/MMP9/CXCL3/CCL20/IL1B/TRADD/CREB5	2.57136852932226
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/314	142/9376	2.10280793038486	DUSP1/HMOX1/MMP9/SQSTM1/CTSL/IL1B/IL1R2/TXN/GSTA3/GSTT1	2.46483328982457
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/314	32/9376	3.73248407643312	GABARAPL2/GABARAPL1/GABARAP/WIPI1	2.88207081342023
NA	NA	hsa03272	Virion - Hepatitis viruses	5/314	48/9376	3.1104033970276	CLDN19/HSPG2/SCARB1/TSG101/CHMP1B	2.72853959604658
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/314	187/9376	1.91614155795497	CTSB/NFKBIA/CXCL2/GABARAPL2/MAPK3/MAP1LC3B/CXCL3/PKN1/GABARAPL1/GABARAP/IL1B/TXN	2.35552487487787
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/314	50/9376	2.9859872611465	AOC1/SAT1/PYCR1/MAOA/OAT	2.62091048579203
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/314	168/9376	1.95511070670306	FTL/FTH1/TNFSF10/IFNGR2/SQSTM1/IL1B/TRADD/STAT4/GLUL/CHMP4C/CHMP1B	2.32522044195753
NA	NA	hsa04382	Cornified envelope formation	13/314	217/9376	1.78884029469606	KRT7/CLDN19/COL17A1/KRT8/S100A10/KRT14/S100A9/S100A11/S100A4/COL4A1/TJP1/SPRR2G/S100A13	2.1884335159578
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/314	196/9376	1.82815546600806	HLA-B/NFKBIA/CXCL2/HLA-A/MAPK3/MAP1LC3B/UBA52/CXCL3/IL6ST/ZFP36/TRADD/CDKN1A	2.18100670659827
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/314	157/9376	1.90190271410605	SERPINE1/HLA-B/HLA-A/MAPK3/CDKN2A/RHEB/SQSTM1/GADD45B/RRAS/CDKN1A	2.12131931292062
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/314	250/9376	1.67215286624204	CLTB/HLA-B/HLA-A/ARPC1B/ARPC2/ARFGAP3/SH3GL1/FOLR1/CHMP4C/TSG101/GRK4/CHMP1B/ARF4/RAB5C	2.00510103126155
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/314	98/9376	2.13284804367607	MAPK3/GSN/ARPC1B/ARPC2/FCGR3A/MARCKS/VAV3	2.09843705253972
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/314	41/9376	2.91315830355756	MAPK3/CDKN2A/MMP9/CDKN1A	2.28519943271742
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/314	100/9376	2.09019108280255	TNFSF10/CXCL2/CCL3/CXCL3/IL6ST/CCL20/CCL4	2.04014337197512
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/314	101/9376	2.06949612158668	SERPINE1/FN1/MAPK3/PLCD3/IL1B/PIM1/COL4A1	2.01150619782088
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/314	144/9376	1.86624203821656	NFKBIA/PRKAG2/CXCL2/C1QB/C1QA/CXCL3/IL1B/TRADD/LY96	1.94989415489549
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/314	168/9376	1.77737336973006	CSH1/CSH2/CSF2RA/IFNGR2/IL6ST/PIM1/CSF2RB/STAT4/CDKN1A/GH2	1.89251825745861
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/314	44/9376	2.71453387376954	ARHGDIB/STX4/CREB5/RAB5C	2.12189298156288
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/314	193/9376	1.70185802448764	NFKBIA/CXCL2/MAPK3/CCL3/CXCL3/CCL20/VAV3/CCL4/CXCL16/GRK4/GNAI2	1.83389330619442
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/314	106/9376	1.9718783800024	NFKBIA/MAPK3/MMP9/IL1R2/FOLR1/CREB5/CDKN1A	1.87311059318153
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/314	28/9376	3.1992720655141	ATP6V0E1/ATP6V0D1/ATP6V1G1	2.16938710879967
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/314	109/9376	1.91760649798399	SPP1/NFKBIA/MAPK3/CCL3/IL1B/CCL4/LY96	1.79365363133022
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	11/314	204/9376	1.61009117022605	TIMP3/IGF2/FN1/MAPK3/MMP9/CTSL/HSPG2/VAV3/RRAS/CDKN1A/CD44	1.63989572434364
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/314	253/9376	1.53430175473931	NFKBIA/MAPK3/MAP1LC3B/ARPC1B/ARPC2/SKP1/PLCD3/UBA52/SQSTM1/IL1B/TRADD/CD44/WIPI1	1.60367536186956
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/314	205/9376	1.60223706695666	HLA-B/NFKBIA/HLA-A/MAPK3/CDKN2A/GSN/ATP6V0D1/IL6ST/TRADD/CREB5/CDKN1A	1.62283549985074
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/314	31/9376	2.88966509143209	GCSH/GLUL/HYI	1.96161813383436
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/314	51/9376	2.34195079305608	ATP6V0E1/ATP6V0D1/ATP6V1G1/TJP1	1.788692526564
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/314	138/9376	1.73100710791101	FN1/NFKBIA/MAPK3/ARPC1B/ARPC2/PKN1/IL1B/VAV3	1.61031410639647
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/314	116/9376	1.80188886448496	ESAM/CLDN19/MMP9/ITGB2/JAM2/VAV3/GNAI2	1.61761854512962
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/314	33/9376	2.71453387376954	VAMP8/SNAP23/STX4	1.83653114872557
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/314	16/9376	3.73248407643312	HEXB/HEXA	2.03618924895899
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	11/314	214/9376	1.5348532650753	HLA-B/NFKBIA/BST2/HLA-A/MAPK3/SKP1/TAPBP/TRADD/B2M/TAPBPL/GNAI2	1.47327842032594
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/314	75/9376	1.99065817409766	MAPK3/CDKN2A/GSTA3/GSTT1/CDKN1A	1.60334901806354
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/314	216/9376	1.52064166076905	TNFSF10/NFKBIA/CXCL2/MAPK3/CCL3/OLR1/MMP9/CXCL3/IL1B/VAV3/LY96	1.4409751410257
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/314	76/9376	1.96446530338585	FABP7/OLR1/LPL/FABP5/CYP27A1	1.57141307977456
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/314	55/9376	2.17162709901563	HEXB/ASAH1/PSAP/HEXA	1.62210114990179
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	5/314	77/9376	1.93895276697824	NFKBIA/MAPK3/CDKN2A/GADD45B/CDKN1A	1.53995992136772
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	13/314	268/9376	1.44842665652629	TUBB2A/MT-ND2/UBE2L6/DUSP1/MT-ND4L/COX4I1/UBA52/MAOA/TXN/PINK1/NDUFA13/SOD1/GNAI2	1.38639103216886
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/314	170/9376	1.58081678531285	IGF2/MAPK3/CDKN2A/HMOX1/GADD45B/GSTA3/GSTT1/CDKN1A/BRD7	1.42254681456389
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/314	18/9376	3.31776362349611	HEXB/HEXA	1.83211321766837
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/314	79/9376	1.88986535515601	CLTB/ATP6V0E1/ATP6V0D1/SLC6A2/ATP6V1G1	1.4784439428668
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/314	37/9376	2.42107075228094	MAPK3/GADD45B/CDKN1A	1.61214762856827
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/314	19/9376	3.14314448541736	HEXB/HEXA	1.74059755895617
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	10/314	200/9376	1.49299363057325	TNFSF10/NFKBIA/CLDN19/TUBB2A/MAPK3/ARPC1B/ARPC2/IL1B/TRADD/TJP1	1.31180123965051
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/314	59/9376	2.02439814315017	GPX4/GPX1/GSTA3/GSTT1	1.4692482224975
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/314	105/9376	1.70627843494086	NFKBIA/FCER1G/MAPK3/IL1B/LSP1/RRAS	1.35470813359146
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/314	20/9376	2.9859872611465	NPL/GMDS	1.65494964098831
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/314	63/9376	1.89586492771206	PIPOX/PLOD3/PLOD2/SMYD3	1.32802558276942
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/314	110/9376	1.62872032426173	SERPINE1/MAPK3/HMOX1/IFNGR2/EPAS1/CDKN1A	1.23465644475135
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/314	110/9376	1.62872032426173	FBN1/NOG/MAPK3/SKP1/LTBP1/HAMP	1.23465644475135
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/314	22/9376	2.71453387376954	AOC1/MAOA	1.49863945011968
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/314	89/9376	1.67752093322837	SPP1/FN1/HSPG2/COL4A1/CD44	1.19541425926856
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/314	89/9376	1.67752093322837	GABARAPL2/GABARAPL1/GABARAP/GLUL/GNAI2	1.19541425926856
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/314	23/9376	2.59651066186652	PRCP/CTSA	1.4269169844611
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/314	138/9376	1.51463121942214	ATP6V0E1/MT-ND2/ATP6V0D1/MT-ND4L/COX4I1/ATP6V1G1/NDUFA13	1.13366601125904
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/314	44/9376	2.03590040532716	HEXB/MAN1A1/HEXA	1.2820217980466
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/314	139/9376	1.50373459194428	CTSD/MAPK3/MMP9/POMC/KRT14/CREB5/GNAI2	1.11373568988117
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/314	140/9376	1.49299363057325	SPP1/SERPINE1/PRKAG2/MAPK3/MAP1LC3B/RRAS/GNAI2	1.09396089356295
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/314	68/9376	1.75646309479206	MAPK3/BCL2A1/PIM1/SPI1	1.16533944659479
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/314	46/9376	1.94738299639989	FTL/FTH1/HMOX1	1.19895287391764
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/314	46/9376	1.94738299639989	PSMB8/PSMB10/PSME1	1.19895287391764
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/314	69/9376	1.73100710791101	FCER1G/MAPK3/ALOX5AP/VAV3	1.13443527294079
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/314	93/9376	1.60536949524005	FN1/NFKBIA/GADD45B/COL4A1/CDKN1A	1.09208455560304
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/314	70/9376	1.70627843494086	NFKBIA/PRKAG2/POMC/TRADD	1.10403254337309
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/314	122/9376	1.46851832515401	CSH1/CSH2/MAPK3/CREB5/GH2/GNAI2	0.96957226354838
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/314	49/9376	1.82815546600806	MAOA/CREB5/GNAI2	1.08187567851001
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	14/314	333/9376	1.25537001970123	SPP1/FN1/HLA-B/ATP6V0E1/HLA-A/MAPK3/ATP6V0D1/RHEB/HES2/ATP6V1G1/TRADD/COL4A1/CREB5/CDKN1A	0.883230778202016
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/314	73/9376	1.63615740336794	MAPK3/CDKN2A/GADD45B/CDKN1A	1.01567073383486
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/314	73/9376	1.63615740336794	MAPK3/CDKN2A/GADD45B/CDKN1A	1.01567073383486
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	10/314	227/9376	1.31541289037291	NFKBIA/MT-ND2/MAPK3/MT-ND4L/HMOX1/COX4I1/GSTA3/GSTT1/NDUFA13/SOD1	0.895455454706075
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/314	201/9376	1.33700922140888	HPGD/ASPSCR1/MMP9/GADD45B/BCL2A1/IL1R2/NUPR1/SPI1/CDKN1A	0.899032123700816
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/314	50/9376	1.7915923566879	HBB/ITGB2/IL1B	1.04466566765309
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/314	125/9376	1.43327388535032	CTSD/FCER1G/MAPK3/ASAH1/TRADD/GNAI2	0.907740292072567
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/314	75/9376	1.59252653927813	SERPINE1/CDKN2A/GADD45B/CDKN1A	0.958985520705471
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/314	51/9376	1.75646309479206	PLA2G7/PLD3/GDPD3	1.0082932185573
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/314	76/9376	1.57157224270868	MAPK3/CDKN2A/GADD45B/CDKN1A	0.931268439699555
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	10/314	232/9376	1.28706347463211	FN1/TMSB4X/MAPK3/GSN/ARPC1B/ARPC2/ITGB2/RGCC/VAV3/RRAS	0.824123416605078
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/314	77/9376	1.5511622135826	MAPK3/CDKN2A/GADD45B/CDKN1A	0.903951454151449
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/314	155/9376	1.34851037600164	MAPK3/CDKN2A/POMC/CREB5/CDKN1A/SCARB1/GNAI2	0.814387284244956
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/314	78/9376	1.53127551853667	FN1/CLTB/ARPC1B/ARPC2	0.87702256513614
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/314	30/9376	1.99065817409766	IL1B/FOLR1	1.01160274621248
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/314	130/9376	1.378147966683	NFKBIA/MAPK3/MMP9/COL4A1/CREB5/GNAI2	0.808155502820045
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/314	10/9376	2.9859872611465	ETHE1	1.16960122649836
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/314	32/9376	1.86624203821656	GAA/GALM	0.913663474650702
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/314	82/9376	1.45657915177878	UPP1/GSTA3/CMPK1/GSTT1	0.772965485803079
NA	NA	hsa04517	IgSF CAM signaling	12/314	299/9376	1.19838953624609	ESAM/TUBB2A/MAPK3/ARPC1B/ARPC2/ITGB2/JAM2/MAG/VAV3/EPB41L3/TJP1/PTPRF	0.648965518411999
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/314	83/9376	1.43903000537181	PRDX1/PRDX5/PIPOX/SOD1	0.747814210909155
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/314	163/9376	1.28232581767027	NFKBIA/MAPK3/MMP9/HSPG2/STAT4/CREB5/CDKN1A	0.676834198975471
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	11/314	275/9376	1.1943949044586	TUBB2A/MT-ND2/MAPK3/C1QB/C1QA/MT-ND4L/COX4I1/IL1B/NDUFA13/CREB5/SOD1	0.609038994692989
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/314	34/9376	1.75646309479206	PRKAG2/SKP1	0.822518558102382
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/314	59/9376	1.51829860736263	UPP1/NT5E/CMPK1	0.743372401328958
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/314	59/9376	1.51829860736263	MAPK3/GADD45B/CDKN1A	0.743372401328958
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/314	35/9376	1.70627843494086	FBP1/GMDS	0.779204972677937
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/314	142/9376	1.26168475823091	UBE2L6/ANAPC13/SKP1/UBE2A/UBA52/ANAPC16	0.584879094315324
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/314	115/9376	1.29825533093326	MAPK3/JUND/CREB5/CDKN1A/GNAI2	0.599027315083878
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/314	62/9376	1.44483254571605	PRKAG2/SOD1/EIF4EBP2	0.654127964111473
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/314	89/9376	1.3420167465827	TUBB2A/MAPK3/TJP1/GNAI2	0.603452492346516
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/314	37/9376	1.6140471681873	HBB/IL1B	0.696611822059724
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/314	63/9376	1.42189869578405	HPGD/PTGES/GPX4	0.625420466865679
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/314	90/9376	1.32710544939844	NFKBIA/MAPK3/IFNGR2/BATF3	0.580407649584824
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/314	91/9376	1.31252187303143	NFKBIA/MAPK3/DAPP1/VAV3	0.557633163190154
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/314	38/9376	1.57157224270868	HEXB/HEXA	0.657165002323924
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/314	38/9376	1.57157224270868	QPRT/NT5E	0.657165002323924
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/314	65/9376	1.378147966683	POMC/CREB5/SCARB1	0.569454091694545
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/314	65/9376	1.378147966683	SPP1/KISS1/MAPK3	0.569454091694545
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	9/314	233/9376	1.15338563735272	FN1/BGN/FBLN1/FBN1/VIM/FMNL2/HSPG2/COL4A1/FHL2	0.441323170183968
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/314	149/9376	1.20241097764288	MT-ND2/MAPK3/MT-ND4L/MGLL/NDUFA13/GNAI2	0.463591398809916
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/314	122/9376	1.22376527096168	PRKAG2/RHEB/FBP1/CREB5/RAB2A	0.463069614616487
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/314	235/9376	1.14356958937525	PRKAG2/MT-ND2/MT-ND4L/MGLL/COX4I1/RHEB/COX14/NDUFA13/CREB5	0.414894777562279
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/314	67/9376	1.33700922140888	FBP1/GALM/BPGM	0.51530707345418
NA	NA	hsa04518	Integrin signaling	6/314	154/9376	1.16337166018695	SPP1/FN1/FBN1/ITGB2/LIMS2/COL4A1	0.380507268531484
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/314	42/9376	1.42189869578405	AOC1/MAOA	0.510078905022002
Organismal Systems	Immune system	hsa04611	Platelet activation	5/314	126/9376	1.18491557982004	VAMP8/FCER1G/SNAP23/MAPK3/GNAI2	0.388979168050698
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/314	70/9376	1.27970882620564	MAPK3/EPAS1/CDKN1A	0.437232161598669
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/314	16/9376	1.86624203821656	MAOA	0.645505216453201
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/314	156/9376	1.1484566389025	NFKBIA/CLDN19/MAPK3/TRADD/CDKN1A/SCARB1	0.348044596627063
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/314	99/9376	1.20645949945313	MAPK3/CDKN2A/MMP9/CDKN1A	0.384403313355272
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/314	157/9376	1.14114162846363	MAPK3/C1QB/C1QA/DUSP2/LIPA/RAB5C	0.331972016087932
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/314	158/9376	1.13391921309361	CDKN2A/ANAPC13/SKP1/GADD45B/ANAPC16/CDKN1A	0.31600322410957
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/314	17/9376	1.75646309479206	CYP27A1	0.581079983494503
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/314	17/9376	1.75646309479206	GLUL	0.581079983494503
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/314	73/9376	1.22711805252596	MAOA/GSTA3/GSTT1	0.362610193412721
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/314	103/9376	1.15960670335786	COL17A1/PRCP/COL4A1/SLC7A7	0.303178250979492
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/314	18/9376	1.65888181174805	PRDX1	0.52082363531275
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/314	75/9376	1.1943949044586	PYCR1/SDS/GLUL	0.314622023347402
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	13/314	368/9376	1.05483245638327	TUBB2A/MT-ND2/MAP1LC3B/MT-ND4L/COX4I1/GPX1/SQSTM1/OPTN/PINK1/NDUFA13/SOD1/WIPI1/ANXA11	0.199749571218599
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/314	19/9376	1.57157224270868	GCSH	0.464213802286919
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/314	49/9376	1.21877031067204	PLOD3/GALNT7	0.28579450116659
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/314	138/9376	1.08187944244438	PRKAG2/MAPK3/RHEB/FBP1/PTPRF	0.180369820984173
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/314	20/9376	1.49299363057325	LIPA	0.410818159757843
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/314	109/9376	1.09577514170514	NFKBIA/PRKAG2/CREB5/PTPRF	0.187212526380325
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/314	110/9376	1.08581354950782	MAPK3/ANAPC13/ANAPC16/GNAI2	0.168517300711135
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/314	170/9376	1.05387785687523	CLDN19/PRKAG2/ARPC1B/ARPC2/JAM2/TJP1	0.131958606589013
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/314	21/9376	1.42189869578405	DSE	0.360275199728204
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/314	21/9376	1.42189869578405	PPCS	0.360275199728204
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/314	83/9376	1.07927250402885	NFKBIA/IL1B/CCL4	0.135027456715462
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/314	205/9376	1.01960540624515	CTSD/MT-ND2/MT-ND4L/MMP9/MPC1/COX4I1/NDUFA13	0.0528302739723375
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/314	115/9376	1.03860426474661	MAPK3/DUSP1/MAOA/GNAI2	0.0775342690089996
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/314	23/9376	1.29825533093326	GLUL	0.266572349048501
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/314	23/9376	1.29825533093326	POLD4	0.266572349048501
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	16/314	480/9376	0.995329087048832	TUBB2A/MT-ND2/MAPK3/UBE2L6/MAP1LC3B/MT-ND4L/COX4I1/UBA52/GPX1/SQSTM1/OPTN/IL1B/PINK1/NDUFA13/SOD1/WIPI1	-0.0195552529766181
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/314	85/9376	1.05387785687523	UPP1/NT5E/CMPK1	0.0928810204929634
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/314	116/9376	1.02965077970569	MAPK3/HOMER3/GLUL/GNAI2	0.0598133397952612
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	10/314	300/9376	0.995329087048832	IGF2/HSPB1/MAPK3/DUSP1/JUND/DUSP2/GADD45B/IL1B/TRADD/RRAS	-0.0153057138888467
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/314	362/9376	0.989830031319281	SPP1/IGF2/CSH1/FN1/CSH2/MAPK3/RHEB/PKN1/COL4A1/CREB5/CDKN1A/GH2	-0.0367327596541428
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/314	24/9376	1.24416135881104	EXTL3	0.222930114106614
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/314	87/9376	1.02965077970569	MAPK3/GADD45B/CDKN1A	0.0517189496589529
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/314	90/9376	0.995329087048832	PRKAG2/RHEB/CREB5	-0.00828794999407149
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	10/314	308/9376	0.969476383489122	CLTB/TUBB2A/MT-ND2/MT-ND4L/COX4I1/GPX1/NDUFA13/CREB5/SOD1/WIPI1	-0.101389743512941
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/314	122/9376	0.979012216769343	MAPK3/PLCD3/RHEB/MED13L	-0.0434330343154057
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/314	26/9376	1.1484566389025	SCARB1	0.141097372241869
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/314	154/9376	0.969476383489122	PRKAG2/MAPK3/RGS2/CDKN1A/GNAI2	-0.0710922440952494
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/314	59/9376	1.01219907157508	MGLL/GNAI2	0.0174965801604192
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/314	60/9376	0.995329087048832	HSPB1/MAPK3	-0.00675617814288954
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/314	60/9376	0.995329087048832	MAPK3/GNAI2	-0.00675617814288954
NA	NA	hsa04081	Hormone signaling	7/314	219/9376	0.954425151964634	IGF2/CSH1/CSH2/POMC/HAMP/GH2/GNAI2	-0.127030823316142
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/314	93/9376	0.963221697144031	MAPK3/TJP1/PTPRF	-0.0663479360062036
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/314	63/9376	0.947932463856031	GADD45B/CDKN1A	-0.0771846490380601
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/314	226/9376	0.924863310974579	NFKBIA/MAPK3/POMC/VAV3/RRAS/CREB5/GNAI2	-0.212830644106863
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/314	98/9376	0.91407773300403	POMC/CREB5/SCARB1	-0.159158564742256
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/314	65/9376	0.918765311121999	MGLL/LPL	-0.122331547555008
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	10/314	323/9376	0.924454260416872	TIMP3/VIM/MAPK3/CDKN2A/HMOX1/MMP9/MARCKS/PIM1/CDKN1A/CD44	-0.257189605055879
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/314	31/9376	0.963221697144031	FBP1	-0.0381787154459444
NA	NA	hsa04981	Folate transport and metabolism	1/314	31/9376	0.963221697144031	FOLR1	-0.0381787154459444
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/314	101/9376	0.886926909251435	MAPK3/POMC/GNAI2	-0.212667646246408
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/314	69/9376	0.865503553955506	CTSB/GNAI2	-0.208722337754102
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/314	69/9376	0.865503553955506	MAOA/CREB5	-0.208722337754102
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/314	138/9376	0.865503553955506	MAPK3/ANAPC13/SKP1/ANAPC16	-0.296278274153258
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/314	70/9376	0.853139217470428	GSTA3/GSTT1	-0.229568220175749
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/314	72/9376	0.829440905874027	NFKBIA/TRADD	-0.270423675580737
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/314	107/9376	0.837192690041074	PRKAG2/FBP1/CREB5	-0.315273727628016
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/314	36/9376	0.829440905874027	GAA	-0.190849543863993
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/314	36/9376	0.829440905874027	GALNT7	-0.190849543863993
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/314	36/9376	0.829440905874027	POLD4	-0.190849543863993
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/314	73/9376	0.818078701683972	BST2/TSG101	-0.290450347009421
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/314	37/9376	0.807023584093648	GLUL	-0.218923984448823
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/314	37/9376	0.807023584093648	MAOA	-0.218923984448823
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/314	37/9376	0.807023584093648	GMDS	-0.218923984448823
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/314	75/9376	0.796263269639066	GPX1/CREB5	-0.329741474010668
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/314	38/9376	0.785786121354341	MAPK3	-0.246292338114362
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/314	39/9376	0.765637759268333	GCSH	-0.272995003898841
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/314	217/9376	0.825618597552027	MAPK3/KLF4/GSTA3/GSTT1/CREB5/GNAI2	-0.483776130913686
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/314	149/9376	0.80160731842859	FCER1G/MAPK3/RHEB/RRAS	-0.454388105992993
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/314	78/9376	0.765637759268333	PLCD3/CDIPT	-0.386882072231897
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/314	78/9376	0.765637759268333	PABPC1/CNOT6L	-0.386882072231897
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/314	184/9376	0.811409581833287	MAPK3/RHOD/RRAS/GNAI2/EPHB2	-0.480907954330035
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/314	115/9376	0.778953198559956	MAPK3/CREB5/GNAI2	-0.443958777065879
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/314	79/9376	0.755946142062404	GSTA3/GSTT1	-0.405477015045557
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/314	116/9376	0.772238084779266	GCSH/SDS/FBP1	-0.459455061982859
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/314	41/9376	0.728289575889389	POLD4	-0.324548421260476
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/314	117/9376	0.765637759268333	MORF4L2/BRD7/ZNHIT1	-0.474828702953511
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	11/314	388/9376	0.846542780221945	APOE/TUBB2A/MT-ND2/MAPK3/MT-ND4L/COX4I1/LPL/IL1B/BACE2/NDUFA13/WIPI1	-0.57465883748012
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/314	43/9376	0.694415642127092	SCARB1	-0.373846352882764
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/314	120/9376	0.746496815286624	ARHGDIB/NFKBIA/MAPK3	-0.520236480628613
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/314	157/9376	0.76076108564242	PRKAG2/COX4I1/IL1B/NDUFA13	-0.56270163232841
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/314	44/9376	0.678633468442386	POLD4	-0.39772056898595
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/314	122/9376	0.734259162577007	NFKBIA/MAPK3/VAV3	-0.549935683247298
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/314	86/9376	0.694415642127092	MAPK3/CDKN1A	-0.529920745723757
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/314	47/9376	0.635316438541808	MAPK3	-0.466536904174327
NA	NA	hsa04519	Cadherin signaling	11/314	404/9376	0.813016333480482	KRT7/NFKBIA/VIM/MAPK3/ARPC1B/ARPC2/KRT8/KRT14/VAV3/RRAS/TJP1	-0.71513519958318
NA	NA	hsa04082	Neuroactive ligand signaling	5/314	199/9376	0.750248055564447	TAC3/POMC/SLC6A2/P2RX4/GNAI2	-0.662862550848083
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/314	166/9376	0.719515002685903	MAPK3/RGS2/CREB5/GNAI2	-0.678691326014837
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/314	91/9376	0.656260936515714	GRK4/GNAI2	-0.613334034586079
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/314	203/9376	0.73546484264692	SPP1/FN1/MAPK3/VAV3/COL4A1	-0.709274186796102
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/314	133/9376	0.673530961160864	MAOA/CREB5/GNAI2	-0.705829454899325
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/314	52/9376	0.574228319451249	SCARB1	-0.573080649520812
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/314	53/9376	0.56339382285783	CLTB	-0.593319199158031
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/314	136/9376	0.658673660547021	NFKBIA/IL1B/TRADD	-0.746348570045801
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/314	97/9376	0.615667476525051	MAPK3/GNAI2	-0.708240651194305
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/314	54/9376	0.552960603916018	SDS	-0.61323447429063
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	5/314	212/9376	0.704242278572287	MAPK3/ITGB2/VAV3/RRAS/GNAI2	-0.810774190379901
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/314	98/9376	0.60938515533602	PLCD3/CDIPT	-0.723557469062751
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/314	99/9376	0.603229749726565	MAPK3/RHEB	-0.738739555457141
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/314	178/9376	0.671008373291348	SFRP1/NOTUM/SKP1/TLE6	-0.824872027865519
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/314	56/9376	0.533212010919017	MAN1A1	-0.652144991651122
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/314	144/9376	0.62208067940552	MAPK3/KLF4/IL6ST	-0.850689116596563
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/314	104/9376	0.574228319451249	PLD3/CDIPT	-0.81272788949752
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/314	148/9376	0.605267688070236	MAPK3/GADD45B/CDKN1A	-0.900986277184606
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/314	370/9376	0.726321225684283	CSH1/CSH2/TAC3/KISS1/TSPO/POMC/P2RX4/PGRMC1/GH2	-0.999803010699688
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/314	62/9376	0.481610848572016	TLE6	-0.762293234851384
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/314	150/9376	0.597197452229299	MAPK3/GADD45B/CDKN1A	-0.925698471347558
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/314	63/9376	0.473966231928015	POLD4	-0.7797897649418
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/314	191/9376	0.625337646313402	MAPK3/MAOA/CREB5/GNAI2	-0.97376821317111
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/314	154/9376	0.581685830093473	QPRT/CMPK1/PPCS	-0.974291269348716
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/314	154/9376	0.581685830093473	MAPK3/CREB5/GNAI2	-0.974291269348716
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/314	67/9376	0.445669740469626	MAPK3	-0.847603820962292
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/314	158/9376	0.566959606546803	MAPK3/RHEB/ATP6V1G1	-1.02182619909242
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/314	238/9376	0.62730824814002	IGF2/MAPK3/RRAS/ETS2/RAB5C	-1.08405449946918
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/314	71/9376	0.420561586076971	MAPK3	-0.912255945198967
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/314	71/9376	0.420561586076971	MAPK3	-0.912255945198967
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/314	76/9376	0.392893060677171	GNAI2	-0.989165480525451
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/314	174/9376	0.514825389852844	SKP1/MAN1A1/OS9	-1.20245825605372
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/314	80/9376	0.373248407643312	MAPK3	-1.04792648156624
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/314	83/9376	0.359757501342951	SKP1	-1.09054605167192
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/314	86/9376	0.347207821063546	CREB5	-1.13202168027368
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/314	87/9376	0.343216926568563	COX4I1	-1.14560666022337
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/314	90/9376	0.331776362349611	SCARB1	-1.18567914915186
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/314	93/9376	0.32107389904801	MAPK3	-1.22478042761545
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/314	93/9376	0.32107389904801	LYZ	-1.22478042761545
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/314	194/9376	0.461750607393788	TUBB2A/DYNLT1/DYNLRB1	-1.41011392879302
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/314	195/9376	0.459382655560999	MAPK3/ITGB2/FCGR3A	-1.42004046544358
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/314	99/9376	0.301614874863283	IL1B	-1.30031098986335
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/314	99/9376	0.301614874863283	PRKAG2	-1.30031098986335
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/314	157/9376	0.38038054282121	SERPINE1/ITGB2	-1.45737528074475
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/314	103/9376	0.289901675839466	PABPC1	-1.34885542657788
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/314	108/9376	0.276480301958009	EEF1A1	-1.40769204997434
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/314	183/9376	0.326337405589781	REXO2/SBDS	-1.71308053983667
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/314	128/9376	0.23328025477707	NT5E	-1.62575895671465
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/314	134/9376	0.222834870234813	MAPK3	-1.68663518771399
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/314	144/9376	0.207360226468507	WIPI1	-1.78421687376058
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/314	254/9376	0.235117107176889	PLCD3/P2RX4	-2.30040978045931
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/314	449/9376	0.0665030570411246	RGS2	-3.77330348303504