ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 28/500 175/18639 0.16 5.96448 2.61865045986292e-14 2.07397116421143e-11 GO:0023023 MHC protein complex binding 13/500 37/18639 0.351351351351351 13.0976756756757 6.31571855850213e-12 2.50102454916684e-09 GO:0023026 MHC class II protein complex binding 11/500 27/18639 0.407407407407407 15.1873333333333 4.10495800321982e-11 1.08370891285003e-08 GO:0042277 peptide binding 27/500 249/18639 0.108433734939759 4.04219277108434 7.90053206313431e-10 1.56430534850059e-07 GO:0042605 peptide antigen binding 12/500 45/18639 0.266666666666667 9.9408 1.56625378636562e-09 2.48094599760314e-07 GO:0008429 phosphatidylethanolamine binding 7/500 17/18639 0.411764705882353 15.3497647058824 1.47672170990557e-07 1.94927265707535e-05 GO:0001540 amyloid-beta binding 13/500 83/18639 0.156626506024096 5.83872289156627 3.04168105722159e-07 3.44144485331357e-05 GO:0016209 antioxidant activity 13/500 86/18639 0.151162790697674 5.63504651162791 4.65144264825713e-07 4.60492822177456e-05 GO:0061134 peptidase regulator activity 21/500 226/18639 0.0929203539823009 3.46388495575221 8.30947343218414e-07 7.31233662032205e-05 GO:0140311 protein sequestering activity 8/500 33/18639 0.242424242424242 9.03709090909091 1.94997931511292e-06 0.000154438361756943 GO:0032395 MHC class II receptor activity 5/500 10/18639 0.5 18.639 3.06978556401454e-06 0.000221024560609047 GO:0033218 amide binding 21/500 247/18639 0.0850202429149798 3.16938461538462 3.47054700289462e-06 0.000229056102191045 GO:0140375 immune receptor activity 16/500 156/18639 0.102564102564103 3.82338461538462 4.75683973574317e-06 0.000279137724233155 GO:0043394 proteoglycan binding 8/500 37/18639 0.216216216216216 8.06010810810811 4.93425270109112e-06 0.000279137724233155 GO:0140313 molecular sequestering activity 9/500 55/18639 0.163636363636364 6.10003636363636 1.42035987148037e-05 0.000749950012141636 GO:0016504 peptidase activator activity 9/500 57/18639 0.157894736842105 5.886 1.91640216380417e-05 0.000948619071083066 GO:0004601 peroxidase activity 8/500 57/18639 0.140350877192982 5.232 0.00013199895447582 0.00601447931112701 GO:0061135 endopeptidase regulator activity 15/500 184/18639 0.0815217391304348 3.03896739130435 0.000136692711616523 0.00601447931112701 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 8/500 59/18639 0.135593220338983 5.05464406779661 0.000169033196005239 0.00704601532821838 GO:0005507 copper ion binding 8/500 63/18639 0.126984126984127 4.73371428571429 0.000268852008771004 0.0106465395473318 GO:0048306 calcium-dependent protein binding 9/500 80/18639 0.1125 4.193775 0.000286535237296669 0.0108064718066172 GO:0004602 glutathione peroxidase activity 5/500 23/18639 0.217391304347826 8.10391304347826 0.000307017861218178 0.0110526430038544 GO:0004857 enzyme inhibitor activity 24/500 416/18639 0.0576923076923077 2.15065384615385 0.000389741546499277 0.0134206654272794 GO:0005201 extracellular matrix structural constituent 13/500 168/18639 0.0773809523809524 2.88460714285714 0.000618121558066475 0.0203980114161937 GO:0005518 collagen binding 8/500 72/18639 0.111111111111111 4.142 0.000673449585328243 0.0213348828631987 GO:0005539 glycosaminoglycan binding 16/500 242/18639 0.0661157024793388 2.46466115702479 0.000870911546793744 0.0265293055792556 GO:0030291 protein serine/threonine kinase inhibitor activity 6/500 46/18639 0.130434782608696 4.86234782608696 0.00136301767385473 0.0387067482127865 GO:0004866 endopeptidase inhibitor activity 12/500 161/18639 0.0745341614906832 2.77848447204969 0.00136842039136114 0.0387067482127865 GO:0071813 lipoprotein particle binding 5/500 32/18639 0.15625 5.8246875 0.00150638680482924 0.0397686116474919 GO:0071814 protein-lipid complex binding 5/500 32/18639 0.15625 5.8246875 0.00150638680482924 0.0397686116474919 GO:0005125 cytokine activity 15/500 234/18639 0.0641025641025641 2.38961538461538 0.00169519141235759 0.043092049436453 GO:0038024 cargo receptor activity 7/500 65/18639 0.107692307692308 4.01455384615385 0.00174109290652335 0.043092049436453 GO:0005131 growth hormone receptor binding 3/500 10/18639 0.3 11.1834 0.00200035953076924 0.0480086287384616 GO:0030414 peptidase inhibitor activity 12/500 169/18639 0.0710059171597633 2.64695857988166 0.00206354083236579 0.0480683629186385 GO:0008201 heparin binding 12/500 172/18639 0.0697674418604651 2.60079069767442 0.00238922124359735 0.0520787325754465 GO:0004197 cysteine-type endopeptidase activity 8/500 88/18639 0.0909090909090909 3.38890909090909 0.00249362991670571 0.0520787325754465 GO:0003823 antigen binding 12/500 174/18639 0.0689655172413793 2.57089655172414 0.00262876137776944 0.0520787325754465 GO:0008199 ferric iron binding 3/500 11/18639 0.272727272727273 10.1667272727273 0.00269599499443599 0.0520787325754465 GO:0019864 IgG binding 3/500 11/18639 0.272727272727273 10.1667272727273 0.00269599499443599 0.0520787325754465 GO:0042608 T cell receptor binding 3/500 11/18639 0.272727272727273 10.1667272727273 0.00269599499443599 0.0520787325754465 GO:0050786 RAGE receptor binding 3/500 11/18639 0.272727272727273 10.1667272727273 0.00269599499443599 0.0520787325754465 GO:0005179 hormone activity 10/500 132/18639 0.0757575757575758 2.82409090909091 0.0029779233300728 0.0561551256528014 GO:0005126 cytokine receptor binding 16/500 275/18639 0.0581818181818182 2.16890181818182 0.00321208895941963 0.059162196647915 GO:0004859 phospholipase inhibitor activity 3/500 12/18639 0.25 9.3195 0.00352353199076864 0.0634235758338356 GO:0030246 carbohydrate binding 16/500 280/18639 0.0571428571428571 2.13017142857143 0.00382698805454722 0.0673549897600311 GO:0004867 serine-type endopeptidase inhibitor activity 8/500 95/18639 0.0842105263157895 3.1392 0.00401047933630805 0.0690499920512168 GO:0004896 cytokine receptor activity 8/500 96/18639 0.0833333333333333 3.1065 0.00427515720899765 0.0720409470111944 GO:0008198 ferrous iron binding 4/500 26/18639 0.153846153846154 5.73507692307692 0.00478684856165365 0.0789830012672852 GO:0048487 beta-tubulin binding 5/500 42/18639 0.119047619047619 4.43785714285714 0.00511071560505355 0.0826058522286206 GO:0004364 glutathione transferase activity 4/500 27/18639 0.148148148148148 5.52266666666667 0.00550208289088666 0.0837111855025031 GO:0005044 scavenger receptor activity 4/500 27/18639 0.148148148148148 5.52266666666667 0.00550208289088666 0.0837111855025031 GO:0019955 cytokine binding 10/500 144/18639 0.0694444444444444 2.58875 0.00552135826501028 0.0837111855025031 GO:0008191 metalloendopeptidase inhibitor activity 3/500 14/18639 0.214285714285714 7.98814285714286 0.00560188488842508 0.0837111855025031 GO:0019209 kinase activator activity 10/500 148/18639 0.0675675675675676 2.51878378378378 0.006669195248221 0.0978148636405747 GO:0005504 fatty acid binding 5/500 47/18639 0.106382978723404 3.96574468085106 0.00826397266942424 0.117134336707784 GO:0055102 lipase inhibitor activity 3/500 16/18639 0.1875 6.989625 0.00828222582782314 0.117134336707784 GO:0030169 low-density lipoprotein particle binding 3/500 17/18639 0.176470588235294 6.57847058823529 0.00985937956868296 0.136993484533279 GO:0051059 NF-kappaB binding 4/500 32/18639 0.125 4.65975 0.010148792262152 0.138583508131455 GO:0019207 kinase regulator activity 15/500 287/18639 0.0522648083623693 1.9483275261324 0.0109910451341855 0.144920186938077 GO:0072341 modified amino acid binding 7/500 91/18639 0.0769230769230769 2.86753846153846 0.0111980109949403 0.144920186938077 GO:0030228 lipoprotein particle receptor activity 3/500 18/18639 0.166666666666667 6.213 0.0115991157101731 0.144920186938077 GO:0034185 apolipoprotein binding 3/500 18/18639 0.166666666666667 6.213 0.0115991157101731 0.144920186938077 GO:0050811 GABA receptor binding 3/500 18/18639 0.166666666666667 6.213 0.0115991157101731 0.144920186938077 GO:0005178 integrin binding 10/500 161/18639 0.062111801242236 2.31540372670807 0.0117107221768143 0.144920186938077 GO:0031406 carboxylic acid binding 11/500 187/18639 0.0588235294117647 2.19282352941176 0.0123436754145659 0.150402937359019 GO:0005080 protein kinase C binding 5/500 52/18639 0.0961538461538462 3.58442307692308 0.0125608897041622 0.150730676449946 GO:0043177 organic acid binding 11/500 189/18639 0.0582010582010582 2.16961904761905 0.0132810530731591 0.155842694218891 GO:0097001 ceramide binding 3/500 19/18639 0.157894736842105 5.886 0.0135040805378898 0.155842694218891 GO:0004175 endopeptidase activity 19/500 405/18639 0.0469135802469136 1.74884444444444 0.0135772044205852 0.155842694218891 GO:0016004 phospholipase activator activity 3/500 20/18639 0.15 5.5917 0.015576330092074 0.176235049041752 GO:0033293 monocarboxylic acid binding 6/500 79/18639 0.0759493670886076 2.83124050632911 0.0193586872514037 0.215944793001574 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/500 22/18639 0.136363636363636 5.08336363636364 0.0202281850611127 0.219461952991798 GO:0061133 endopeptidase activator activity 3/500 22/18639 0.136363636363636 5.08336363636364 0.0202281850611127 0.219461952991798 GO:0019887 protein kinase regulator activity 13/500 255/18639 0.0509803921568627 1.90044705882353 0.0206260281227407 0.219632810962308 GO:0001786 phosphatidylserine binding 5/500 59/18639 0.0847457627118644 3.15915254237288 0.020798561644158 0.219632810962308 GO:0003714 transcription corepressor activity 11/500 204/18639 0.053921568627451 2.01008823529412 0.0221217402642551 0.230531819595921 GO:0001530 lipopolysaccharide binding 4/500 41/18639 0.0975609756097561 3.63687804878049 0.0236856684130076 0.243624017962363 GO:0016298 lipase activity 8/500 130/18639 0.0615384615384615 2.29403076923077 0.0240110958401744 0.243804973146387 GO:0004860 protein kinase inhibitor activity 6/500 84/18639 0.0714285714285714 2.66271428571429 0.0253519828008212 0.243904879517565 GO:0042625 ATPase-coupled ion transmembrane transporter activity 3/500 24/18639 0.125 4.65975 0.0255607386363105 0.243904879517565 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 3/500 24/18639 0.125 4.65975 0.0255607386363105 0.243904879517565 GO:0046961 proton-transporting ATPase activity, rotational mechanism 3/500 24/18639 0.125 4.65975 0.0255607386363105 0.243904879517565 GO:0060229 lipase activator activity 3/500 24/18639 0.125 4.65975 0.0255607386363105 0.243904879517565 GO:0004620 phospholipase activity 7/500 109/18639 0.0642201834862385 2.394 0.027486040474198 0.25510077787899 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/500 10/18639 0.2 7.4556 0.028022433933677 0.25510077787899 GO:0043208 glycosphingolipid binding 2/500 10/18639 0.2 7.4556 0.028022433933677 0.25510077787899 GO:0070513 death domain binding 2/500 10/18639 0.2 7.4556 0.028022433933677 0.25510077787899 GO:0120020 cholesterol transfer activity 3/500 25/18639 0.12 4.47336 0.0284821821872784 0.256339639685505 GO:0019843 rRNA binding 5/500 65/18639 0.0769230769230769 2.86753846153846 0.0301617685946354 0.264195211131715 GO:0002020 protease binding 8/500 136/18639 0.0588235294117647 2.19282352941176 0.0303557628951845 0.264195211131715 GO:0019838 growth factor binding 8/500 136/18639 0.0588235294117647 2.19282352941176 0.0303557628951845 0.264195211131715 GO:0005200 structural constituent of cytoskeleton 7/500 112/18639 0.0625 2.329875 0.0312474711894425 0.26459572729209 GO:0019865 immunoglobulin binding 3/500 26/18639 0.115384615384615 4.30130769230769 0.0315728778775773 0.26459572729209 GO:0008009 chemokine activity 4/500 45/18639 0.0888888888888889 3.3136 0.0320748545738334 0.26459572729209 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/500 11/18639 0.181818181818182 6.77781818181818 0.0336505314757305 0.26459572729209 GO:0019215 intermediate filament binding 2/500 11/18639 0.181818181818182 6.77781818181818 0.0336505314757305 0.26459572729209 GO:1990948 ubiquitin ligase inhibitor activity 2/500 11/18639 0.181818181818182 6.77781818181818 0.0336505314757305 0.26459572729209 GO:0050840 extracellular matrix binding 5/500 67/18639 0.0746268656716418 2.78194029850746 0.0337863406621334 0.26459572729209 GO:0030295 protein kinase activator activity 8/500 139/18639 0.0575539568345324 2.1454964028777 0.0339236935322648 0.26459572729209 GO:0031625 ubiquitin protein ligase binding 14/500 302/18639 0.0463576158940397 1.72811920529801 0.0339847745178377 0.26459572729209 GO:0019210 kinase inhibitor activity 6/500 90/18639 0.0666666666666667 2.4852 0.0340329895262741 0.26459572729209 GO:0003924 GTPase activity 15/500 331/18639 0.0453172205438066 1.68933534743202 0.0342660913549073 0.26459572729209 GO:0004180 carboxypeptidase activity 4/500 46/18639 0.0869565217391304 3.2415652173913 0.034410807968542 0.26459572729209 GO:1901681 sulfur compound binding 13/500 275/18639 0.0472727272727273 1.76223272727273 0.035096410385793 0.267272663707193 GO:0046625 sphingolipid binding 3/500 28/18639 0.107142857142857 3.99407142857143 0.0382573011231372 0.283776389867689 GO:0008603 cAMP-dependent protein kinase regulator activity 2/500 12/18639 0.166666666666667 6.213 0.0396759313727228 0.283776389867689 GO:0016208 AMP binding 2/500 12/18639 0.166666666666667 6.213 0.0396759313727228 0.283776389867689 GO:0070008 serine-type exopeptidase activity 2/500 12/18639 0.166666666666667 6.213 0.0396759313727228 0.283776389867689 GO:0097371 MDM2/MDM4 family protein binding 2/500 12/18639 0.166666666666667 6.213 0.0396759313727228 0.283776389867689 GO:0097110 scaffold protein binding 5/500 70/18639 0.0714285714285714 2.66271428571429 0.0397103479639024 0.283776389867689 GO:0022853 active monoatomic ion transmembrane transporter activity 7/500 118/18639 0.0593220338983051 2.21140677966102 0.0397716910041837 0.283776389867689 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/500 29/18639 0.103448275862069 3.85634482758621 0.04184786514731 0.293305391120969 GO:0051861 glycolipid binding 3/500 29/18639 0.103448275862069 3.85634482758621 0.04184786514731 0.293305391120969 GO:0042379 chemokine receptor binding 5/500 72/18639 0.0694444444444444 2.58875 0.0439888810447611 0.305606963047814 GO:0001968 fibronectin binding 3/500 30/18639 0.1 3.7278 0.0456014040629176 0.309238137332664 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/500 13/18639 0.153846153846154 5.73507692307692 0.0460733588450182 0.309238137332664 GO:0008035 high-density lipoprotein particle binding 2/500 13/18639 0.153846153846154 5.73507692307692 0.0460733588450182 0.309238137332664 GO:0035325 Toll-like receptor binding 2/500 13/18639 0.153846153846154 5.73507692307692 0.0460733588450182 0.309238137332664 GO:0005543 phospholipid binding 20/500 497/18639 0.0402414486921529 1.50012072434608 0.0476546398248689 0.317163653288203 GO:0005164 tumor necrosis factor receptor binding 3/500 31/18639 0.0967741935483871 3.60754838709677 0.0495156446860888 0.326803254928186 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 15/500 349/18639 0.0429799426934097 1.60220630372493 0.050275308957202 0.329074749538049 GO:0019003 GDP binding 5/500 75/18639 0.0666666666666667 2.4852 0.0509054662456964 0.33046827267698 GO:0008494 translation activator activity 2/500 14/18639 0.142857142857143 5.32542857142857 0.0528186045044503 0.332990873589625 GO:0019763 immunoglobulin receptor activity 2/500 14/18639 0.142857142857143 5.32542857142857 0.0528186045044503 0.332990873589625 GO:0044548 S100 protein binding 2/500 14/18639 0.142857142857143 5.32542857142857 0.0528186045044503 0.332990873589625 GO:0044389 ubiquitin-like protein ligase binding 14/500 322/18639 0.0434782608695652 1.62078260869565 0.0529758207983494 0.332990873589625 GO:0120015 sterol transfer activity 3/500 32/18639 0.09375 3.4948125 0.0535880776954616 0.333513531596987 GO:0003779 actin binding 18/500 443/18639 0.0406320541760722 1.51468171557562 0.0539011768237554 0.333513531596987 GO:0051015 actin filament binding 10/500 209/18639 0.0478468899521531 1.78363636363636 0.0559019809883353 0.341254637578981 GO:0005506 iron ion binding 8/500 154/18639 0.051948051948052 1.93651948051948 0.0560140187945296 0.341254637578981 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/500 54/18639 0.0740740740740741 2.76133333333333 0.0565692914281186 0.34200670848145 GO:0004129 cytochrome-c oxidase activity 2/500 15/18639 0.133333333333333 4.9704 0.0598884855698479 0.346216646505982 GO:0005041 low-density lipoprotein particle receptor activity 2/500 15/18639 0.133333333333333 4.9704 0.0598884855698479 0.346216646505982 GO:0015929 hexosaminidase activity 2/500 15/18639 0.133333333333333 4.9704 0.0598884855698479 0.346216646505982 GO:0031386 protein tag activity 2/500 15/18639 0.133333333333333 4.9704 0.0598884855698479 0.346216646505982 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/500 15/18639 0.133333333333333 4.9704 0.0598884855698479 0.346216646505982 GO:0141047 molecular tag activity 2/500 15/18639 0.133333333333333 4.9704 0.0598884855698479 0.346216646505982 GO:0051427 hormone receptor binding 3/500 34/18639 0.0882352941176471 3.28923529411765 0.0621964256025972 0.356953399110558 GO:0030170 pyridoxal phosphate binding 4/500 56/18639 0.0714285714285714 2.66271428571429 0.0630657341927991 0.359338571803574 GO:0008234 cysteine-type peptidase activity 9/500 187/18639 0.0481283422459893 1.79412834224599 0.0655168695492888 0.369934446145755 GO:0070279 vitamin B6 binding 4/500 57/18639 0.0701754385964912 2.616 0.0664547068771295 0.369934446145755 GO:0005149 interleukin-1 receptor binding 2/500 16/18639 0.125 4.65975 0.0672608083901372 0.369934446145755 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/500 16/18639 0.125 4.65975 0.0672608083901372 0.369934446145755 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/500 16/18639 0.125 4.65975 0.0672608083901372 0.369934446145755 GO:0005484 SNAP receptor activity 3/500 36/18639 0.0833333333333333 3.1065 0.071402407406659 0.390004873559131 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/500 17/18639 0.117647058823529 4.38564705882353 0.0749143322329977 0.403620075704314 GO:0036041 long-chain fatty acid binding 2/500 17/18639 0.117647058823529 4.38564705882353 0.0749143322329977 0.403620075704314 GO:0008236 serine-type peptidase activity 9/500 194/18639 0.0463917525773196 1.72939175257732 0.0783848022227682 0.419464617300219 GO:0015026 coreceptor activity 4/500 61/18639 0.0655737704918033 2.44445901639344 0.0809292304472534 0.427306336761498 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/500 61/18639 0.0655737704918033 2.44445901639344 0.0809292304472534 0.427306336761498 GO:0016854 racemase and epimerase activity 2/500 18/18639 0.111111111111111 4.142 0.0828287342983508 0.434439454068171 GO:0017171 serine hydrolase activity 9/500 198/18639 0.0454545454545455 1.69445454545455 0.0863831723175623 0.450101792602035 GO:0015245 fatty acid transmembrane transporter activity 2/500 19/18639 0.105263157894737 3.924 0.0909845759172286 0.461573491780763 GO:0043395 heparan sulfate proteoglycan binding 2/500 19/18639 0.105263157894737 3.924 0.0909845759172286 0.461573491780763 GO:0070003 threonine-type peptidase activity 2/500 19/18639 0.105263157894737 3.924 0.0909845759172286 0.461573491780763 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/500 40/18639 0.075 2.79585 0.0914987856181564 0.461573491780763 GO:0071855 neuropeptide receptor binding 3/500 40/18639 0.075 2.79585 0.0914987856181564 0.461573491780763 GO:0004536 DNA nuclease activity 4/500 64/18639 0.0625 2.329875 0.0927205474896657 0.464776415264654 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 5/500 91/18639 0.0549450549450549 2.04824175824176 0.0978525657894363 0.485775986167029 GO:0016505 peptidase activator activity involved in apoptotic process 2/500 20/18639 0.1 3.7278 0.0993632698978014 0.485775986167029 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/500 20/18639 0.1 3.7278 0.0993632698978014 0.485775986167029 GO:0031418 L-ascorbic acid binding 2/500 20/18639 0.1 3.7278 0.0993632698978014 0.485775986167029 GO:0042056 chemoattractant activity 3/500 42/18639 0.0714285714285714 2.66271428571429 0.102330262470748 0.497212072864001 GO:0008375 acetylglucosaminyltransferase activity 3/500 43/18639 0.0697674418604651 2.60079069767442 0.107928249965507 0.519900693016168 GO:0140297 DNA-binding transcription factor binding 18/500 488/18639 0.0368852459016393 1.37500819672131 0.108659677838763 0.519900693016168 GO:0019842 vitamin binding 7/500 150/18639 0.0466666666666667 1.73964 0.109476280338035 0.519900693016168 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/500 68/18639 0.0588235294117647 2.19282352941176 0.109625524916288 0.519900693016168 GO:0016853 isomerase activity 8/500 180/18639 0.0444444444444444 1.6568 0.112182360581579 0.528859699884588 GO:0015377 chloride:monoatomic cation symporter activity 2/500 22/18639 0.0909090909090909 3.38890909090909 0.116718935373572 0.546990513703369 GO:0015078 proton transmembrane transporter activity 8/500 185/18639 0.0432432432432432 1.61202162162162 0.125585159804902 0.585079097444012 GO:0043130 ubiquitin binding 5/500 100/18639 0.05 1.8639 0.131306856570068 0.605240376682323 GO:0043495 protein-membrane adaptor activity 3/500 47/18639 0.0638297872340425 2.37944680851064 0.131441091905757 0.605240376682323 GO:0004622 lysophospholipase activity 2/500 24/18639 0.0833333333333333 3.1065 0.134762890646888 0.606433007910995 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/500 24/18639 0.0833333333333333 3.1065 0.134762890646888 0.606433007910995 GO:0048027 mRNA 5'-UTR binding 2/500 24/18639 0.0833333333333333 3.1065 0.134762890646888 0.606433007910995 GO:0050431 transforming growth factor beta binding 2/500 24/18639 0.0833333333333333 3.1065 0.134762890646888 0.606433007910995 GO:0048029 monosaccharide binding 4/500 74/18639 0.0540540540540541 2.01502702702703 0.137325049990808 0.612149439767542 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/500 48/18639 0.0625 2.329875 0.137579040755836 0.612149439767542 GO:0008238 exopeptidase activity 5/500 102/18639 0.0490196078431373 1.82735294117647 0.139364401862723 0.61318126653196 GO:0016763 pentosyltransferase activity 3/500 49/18639 0.0612244897959184 2.28232653061224 0.143812634654334 0.61318126653196 GO:0035254 glutamate receptor binding 3/500 49/18639 0.0612244897959184 2.28232653061224 0.143812634654334 0.61318126653196 GO:0001848 complement binding 2/500 25/18639 0.08 2.98224 0.144004691382506 0.61318126653196 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/500 25/18639 0.08 2.98224 0.144004691382506 0.61318126653196 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/500 25/18639 0.08 2.98224 0.144004691382506 0.61318126653196 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/500 25/18639 0.08 2.98224 0.144004691382506 0.61318126653196 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/500 25/18639 0.08 2.98224 0.144004691382506 0.61318126653196 GO:0008083 growth factor activity 7/500 162/18639 0.0432098765432099 1.61077777777778 0.146068246036246 0.618641983212337 GO:0032813 tumor necrosis factor receptor superfamily binding 3/500 50/18639 0.06 2.23668 0.150137742303001 0.622934437262923 GO:0048020 CCR chemokine receptor binding 3/500 50/18639 0.06 2.23668 0.150137742303001 0.622934437262923 GO:0004529 DNA exonuclease activity 2/500 26/18639 0.0769230769230769 2.86753846153846 0.153374009174583 0.622934437262923 GO:0030247 polysaccharide binding 2/500 26/18639 0.0769230769230769 2.86753846153846 0.153374009174583 0.622934437262923 GO:0043548 phosphatidylinositol 3-kinase binding 2/500 26/18639 0.0769230769230769 2.86753846153846 0.153374009174583 0.622934437262923 GO:0050681 nuclear androgen receptor binding 2/500 26/18639 0.0769230769230769 2.86753846153846 0.153374009174583 0.622934437262923 GO:0050750 low-density lipoprotein particle receptor binding 2/500 26/18639 0.0769230769230769 2.86753846153846 0.153374009174583 0.622934437262923 GO:0070412 R-SMAD binding 2/500 26/18639 0.0769230769230769 2.86753846153846 0.153374009174583 0.622934437262923 GO:0015399 primary active transmembrane transporter activity 7/500 166/18639 0.0421686746987952 1.57196385542169 0.159415250397637 0.644167746504736 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/500 27/18639 0.0740740740740741 2.76133333333333 0.162857391728477 0.651429566913907 GO:0035255 ionotropic glutamate receptor binding 2/500 27/18639 0.0740740740740741 2.76133333333333 0.162857391728477 0.651429566913907 GO:0005544 calcium-dependent phospholipid binding 3/500 53/18639 0.0566037735849057 2.11007547169811 0.169620990507827 0.675074494885423 GO:0016866 intramolecular transferase activity 2/500 28/18639 0.0714285714285714 2.66271428571429 0.172442014082734 0.679473010714055 GO:0051019 mitogen-activated protein kinase binding 2/500 28/18639 0.0714285714285714 2.66271428571429 0.172442014082734 0.679473010714055 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/500 54/18639 0.0555555555555556 2.071 0.176271090453693 0.688574023043178 GO:0001664 G protein-coupled receptor binding 11/500 297/18639 0.037037037037037 1.38066666666667 0.176490563987077 0.688574023043178 GO:0004629 phospholipase C activity 2/500 29/18639 0.0689655172413793 2.57089655172414 0.182115654744617 0.707037247832043 GO:0045296 cadherin binding 12/500 334/18639 0.0359281437125748 1.33932934131737 0.188602942311062 0.728651367367616 GO:0170055 lipid transmembrane transporter activity 3/500 56/18639 0.0535714285714286 1.99703571428571 0.189780582065861 0.729641849495931 GO:0001965 G-protein alpha-subunit binding 2/500 30/18639 0.0666666666666667 2.4852 0.191866672650453 0.730569253553647 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/500 30/18639 0.0666666666666667 2.4852 0.191866672650453 0.730569253553647 GO:0004252 serine-type endopeptidase activity 7/500 176/18639 0.0397727272727273 1.48264772727273 0.19504239261037 0.739108014102455 GO:0070325 lipoprotein particle receptor binding 2/500 31/18639 0.0645161290322581 2.40503225806452 0.201683984923857 0.760636743141404 GO:0008081 phosphoric diester hydrolase activity 4/500 87/18639 0.0459770114942529 1.71393103448276 0.205339121961478 0.764169753493183 GO:0043425 bHLH transcription factor binding 2/500 32/18639 0.0625 2.329875 0.21155704540575 0.764169753493183 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/500 60/18639 0.05 1.8639 0.217526293138928 0.764169753493183 GO:0032182 ubiquitin-like protein binding 5/500 120/18639 0.0416666666666667 1.55325 0.220392580452959 0.764169753493183 GO:0030296 protein tyrosine kinase activator activity 2/500 33/18639 0.0606060606060606 2.25927272727273 0.221475823930882 0.764169753493183 GO:0003796 lysozyme activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0004090 carbonyl reductase (NADPH) activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0004955 prostaglandin receptor activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0005345 purine nucleobase transmembrane transporter activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0005528 FK506 binding 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0008190 eukaryotic initiation factor 4E binding 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0008239 dipeptidyl-peptidase activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0016783 sulfurtransferase activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0016868 intramolecular phosphotransferase activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0030957 Tat protein binding 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0031720 haptoglobin binding 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0035256 G protein-coupled glutamate receptor binding 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0043295 glutathione binding 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0043422 protein kinase B binding 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0050308 sugar-phosphatase activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0140999 histone H3K4 trimethyltransferase activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0141109 transporter activator activity 1/500 10/18639 0.1 3.7278 0.23813431591948 0.764169753493183 GO:0051213 dioxygenase activity 4/500 93/18639 0.043010752688172 1.60335483870968 0.239526273901581 0.764169753493183 GO:0000175 3'-5'-RNA exonuclease activity 2/500 35/18639 0.0571428571428571 2.13017142857143 0.241412875108744 0.764169753493183 GO:0005154 epidermal growth factor receptor binding 2/500 35/18639 0.0571428571428571 2.13017142857143 0.241412875108744 0.764169753493183 GO:0061631 ubiquitin conjugating enzyme activity 2/500 35/18639 0.0571428571428571 2.13017142857143 0.241412875108744 0.764169753493183 GO:0004190 aspartic-type endopeptidase activity 2/500 36/18639 0.0555555555555556 2.071 0.251413490855926 0.764169753493183 GO:0045505 dynein intermediate chain binding 2/500 36/18639 0.0555555555555556 2.071 0.251413490855926 0.764169753493183 GO:0055106 ubiquitin-protein transferase regulator activity 2/500 36/18639 0.0555555555555556 2.071 0.251413490855926 0.764169753493183 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/500 36/18639 0.0555555555555556 2.071 0.251413490855926 0.764169753493183 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/500 36/18639 0.0555555555555556 2.071 0.251413490855926 0.764169753493183 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/500 36/18639 0.0555555555555556 2.071 0.251413490855926 0.764169753493183 GO:0120013 lipid transfer activity 3/500 65/18639 0.0461538461538462 1.72052307692308 0.253257817708663 0.764169753493183 GO:0003712 transcription coregulator activity 16/500 495/18639 0.0323232323232323 1.20494545454545 0.257175540839774 0.764169753493183 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0001851 complement component C3b binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0004954 prostanoid receptor activity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0005114 type II transforming growth factor beta receptor binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0008046 axon guidance receptor activity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0008503 benzodiazepine receptor activity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0010854 adenylate cyclase regulator activity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0015205 nucleobase transmembrane transporter activity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0019203 carbohydrate phosphatase activity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0019206 nucleoside kinase activity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0031731 CCR6 chemokine receptor binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0032050 clathrin heavy chain binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0034713 type I transforming growth factor beta receptor binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0048185 activin binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0048407 platelet-derived growth factor binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0050998 nitric-oxide synthase binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0097493 structural molecule activity conferring elasticity 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:1900750 oligopeptide binding 1/500 11/18639 0.0909090909090909 3.38890909090909 0.258582694363855 0.764169753493183 GO:0070001 aspartic-type peptidase activity 2/500 37/18639 0.0540540540540541 2.01502702702703 0.261424474232951 0.769695849786234 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/500 130/18639 0.0384615384615385 1.43376923076923 0.27046470898699 0.789744391446593 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/500 38/18639 0.0526315789473684 1.962 0.271438088648865 0.789744391446593 GO:0005527 macrolide binding 1/500 12/18639 0.0833333333333333 3.1065 0.27848330918123 0.789744391446593 GO:0008504 monoamine transmembrane transporter activity 1/500 12/18639 0.0833333333333333 3.1065 0.27848330918123 0.789744391446593 GO:0015132 prostaglandin transmembrane transporter activity 1/500 12/18639 0.0833333333333333 3.1065 0.27848330918123 0.789744391446593 GO:0016840 carbon-nitrogen lyase activity 1/500 12/18639 0.0833333333333333 3.1065 0.27848330918123 0.789744391446593 GO:0035259 nuclear glucocorticoid receptor binding 1/500 12/18639 0.0833333333333333 3.1065 0.27848330918123 0.789744391446593 GO:0035497 cAMP response element binding 1/500 12/18639 0.0833333333333333 3.1065 0.27848330918123 0.789744391446593 GO:0097677 STAT family protein binding 1/500 12/18639 0.0833333333333333 3.1065 0.27848330918123 0.789744391446593 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/500 39/18639 0.0512820512820513 1.91169230769231 0.281447003524567 0.789744391446593 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/500 70/18639 0.0428571428571429 1.59762857142857 0.289739737566096 0.789744391446593 GO:0016757 glycosyltransferase activity 9/500 267/18639 0.0337078651685393 1.25656179775281 0.289934683673681 0.789744391446593 GO:0004532 RNA exonuclease activity 2/500 40/18639 0.05 1.8639 0.29144427815122 0.789744391446593 GO:0015036 disulfide oxidoreductase activity 2/500 40/18639 0.05 1.8639 0.29144427815122 0.789744391446593 GO:0004465 lipoprotein lipase activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0004535 poly(A)-specific ribonuclease activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0005542 folic acid binding 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0008253 5'-nucleotidase activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0009982 pseudouridine synthase activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0017154 semaphorin receptor activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0035673 oligopeptide transmembrane transporter activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0045159 myosin II binding 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0046975 histone H3K36 methyltransferase activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0061459 L-arginine transmembrane transporter activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0071714 icosanoid transmembrane transporter activity 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0089720 caspase binding 1/500 13/18639 0.0769230769230769 2.86753846153846 0.297850805042581 0.789744391446593 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/500 41/18639 0.0487804878048781 1.81843902439024 0.301423346119696 0.789744391446593 GO:0017080 sodium channel regulator activity 2/500 41/18639 0.0487804878048781 1.81843902439024 0.301423346119696 0.789744391446593 GO:0042287 MHC protein binding 2/500 41/18639 0.0487804878048781 1.81843902439024 0.301423346119696 0.789744391446593 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/500 41/18639 0.0487804878048781 1.81843902439024 0.301423346119696 0.789744391446593 GO:0141108 transporter regulator activity 6/500 170/18639 0.0352941176470588 1.31569411764706 0.305988804243606 0.789744391446593 GO:0016922 nuclear receptor binding 5/500 137/18639 0.0364963503649635 1.36051094890511 0.306852178333824 0.789744391446593 GO:0004520 DNA endonuclease activity 2/500 42/18639 0.0476190476190476 1.77514285714286 0.311378000302144 0.789744391446593 GO:0016859 cis-trans isomerase activity 2/500 42/18639 0.0476190476190476 1.77514285714286 0.311378000302144 0.789744391446593 GO:0043539 protein serine/threonine kinase activator activity 3/500 73/18639 0.0410958904109589 1.53197260273973 0.31181845063554 0.789744391446593 GO:0004705 JUN kinase activity 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0005344 oxygen carrier activity 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0005545 1-phosphatidylinositol binding 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0008474 palmitoyl-(protein) hydrolase activity 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0015926 glucosidase activity 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0016530 metallochaperone activity 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0043176 amine binding 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0061783 peptidoglycan muralytic activity 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0098599 palmitoyl hydrolase activity 1/500 14/18639 0.0714285714285714 2.66271428571429 0.316699435853207 0.789744391446593 GO:0000149 SNARE binding 4/500 106/18639 0.0377358490566038 1.40671698113208 0.317143162778764 0.789744391446593 GO:0070851 growth factor receptor binding 5/500 139/18639 0.0359712230215827 1.34093525179856 0.31738458069093 0.789744391446593 GO:0035064 methylated histone binding 3/500 74/18639 0.0405405405405405 1.51127027027027 0.319191411226162 0.789744391446593 GO:0140030 modification-dependent protein binding 6/500 173/18639 0.0346820809248555 1.29287861271676 0.320112768823483 0.789744391446593 GO:0048156 tau protein binding 2/500 43/18639 0.0465116279069767 1.73386046511628 0.321302378367345 0.789744391446593 GO:0044183 protein folding chaperone 3/500 75/18639 0.04 1.49112 0.326566313404994 0.789744391446593 GO:0003954 NADH dehydrogenase activity 2/500 44/18639 0.0454545454545455 1.69445454545455 0.331190948812132 0.789744391446593 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/500 44/18639 0.0454545454545455 1.69445454545455 0.331190948812132 0.789744391446593 GO:0020037 heme binding 5/500 142/18639 0.0352112676056338 1.31260563380282 0.333262695149467 0.789744391446593 GO:0098631 cell adhesion mediator activity 3/500 76/18639 0.0394736842105263 1.4715 0.333940415603735 0.789744391446593 GO:0140034 methylation-dependent protein binding 3/500 76/18639 0.0394736842105263 1.4715 0.333940415603735 0.789744391446593 GO:0004559 alpha-mannosidase activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0004953 icosanoid receptor activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0008252 nucleotidase activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0016846 carbon-sulfur lyase activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0017081 chloride channel regulator activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0033130 acetylcholine receptor binding 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0047372 monoacylglycerol lipase activity 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0120283 protein serine/threonine kinase binding 1/500 15/18639 0.0666666666666667 2.4852 0.335043075159161 0.789744391446593 GO:0043021 ribonucleoprotein complex binding 6/500 177/18639 0.0338983050847458 1.26366101694915 0.339087339016784 0.795936742775157 GO:0141110 transporter inhibitor activity 2/500 45/18639 0.0444444444444444 1.6568 0.341038497491672 0.795936742775157 GO:0004222 metalloendopeptidase activity 4/500 110/18639 0.0363636363636364 1.35556363636364 0.341530579779854 0.795936742775157 GO:0005319 lipid transporter activity 6/500 178/18639 0.0337078651685393 1.25656179775281 0.343851183119745 0.795936742775157 GO:0008194 UDP-glycosyltransferase activity 5/500 145/18639 0.0344827586206897 1.28544827586207 0.349210002300015 0.795936742775157 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0004707 MAP kinase activity 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0005024 transforming growth factor beta receptor activity 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0005159 insulin-like growth factor receptor binding 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0008296 3'-5'-DNA exonuclease activity 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0015378 sodium:chloride symporter activity 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0015923 mannosidase activity 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0016722 oxidoreductase activity, acting on metal ions 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0022841 potassium ion leak channel activity 1/500 16/18639 0.0625 2.329875 0.352895226277096 0.795936742775157 GO:0043022 ribosome binding 4/500 112/18639 0.0357142857142857 1.33135714285714 0.353749663455626 0.795936742775157 GO:0004550 nucleoside diphosphate kinase activity 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0005092 GDP-dissociation inhibitor activity 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0016018 cyclosporin A binding 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0019198 transmembrane receptor protein phosphatase activity 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0030548 acetylcholine receptor regulator activity 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0048038 quinone binding 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0070403 NAD+ binding 1/500 17/18639 0.0588235294117647 2.19282352941176 0.370269032154852 0.801277571043673 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/500 48/18639 0.0416666666666667 1.55325 0.370287362376243 0.801277571043673 GO:0038187 pattern recognition receptor activity 2/500 48/18639 0.0416666666666667 1.55325 0.370287362376243 0.801277571043673 GO:0140693 molecular condensate scaffold activity 2/500 48/18639 0.0416666666666667 1.55325 0.370287362376243 0.801277571043673 GO:0009055 electron transfer activity 4/500 116/18639 0.0344827586206897 1.28544827586207 0.378177099527014 0.806958972884719 GO:0008135 translation factor activity, RNA binding 3/500 83/18639 0.036144578313253 1.34739759036145 0.385321878559511 0.806958972884719 GO:0046906 tetrapyrrole binding 5/500 152/18639 0.0328947368421053 1.22625 0.38653009239641 0.806958972884719 GO:0000400 four-way junction DNA binding 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0000900 mRNA regulatory element binding translation repressor activity 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0003746 translation elongation factor activity 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0008409 5'-3' exonuclease activity 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0015373 monoatomic anion:sodium symporter activity 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0032393 MHC class I receptor activity 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0070064 proline-rich region binding 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0098641 cadherin binding involved in cell-cell adhesion 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0099602 neurotransmitter receptor regulator activity 1/500 18/18639 0.0555555555555556 2.071 0.387177284969941 0.806958972884719 GO:0004527 exonuclease activity 3/500 84/18639 0.0357142857142857 1.33135714285714 0.392599690302226 0.811362662168812 GO:0051117 ATPase binding 3/500 84/18639 0.0357142857142857 1.33135714285714 0.392599690302226 0.811362662168812 GO:0180051 translation factor activity 3/500 84/18639 0.0357142857142857 1.33135714285714 0.392599690302226 0.811362662168812 GO:0003743 translation initiation factor activity 2/500 51/18639 0.0392156862745098 1.46188235294118 0.399007150740983 0.811362662168812 GO:0016830 carbon-carbon lyase activity 2/500 51/18639 0.0392156862745098 1.46188235294118 0.399007150740983 0.811362662168812 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0008301 DNA binding, bending 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0022840 leak channel activity 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0022842 narrow pore channel activity 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0042800 histone H3K4 methyltransferase activity 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0042834 peptidoglycan binding 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0046527 glucosyltransferase activity 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0050145 nucleoside monophosphate kinase activity 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0140036 ubiquitin-modified protein reader activity 1/500 19/18639 0.0526315789473684 1.962 0.403632435472869 0.811362662168812 GO:0051082 unfolded protein binding 4/500 121/18639 0.0330578512396694 1.2323305785124 0.408572943540482 0.819214610845725 GO:0016860 intramolecular oxidoreductase activity 2/500 53/18639 0.0377358490566038 1.40671698113208 0.4178112668007 0.820642244071629 GO:0001614 purinergic nucleotide receptor activity 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0001972 retinoic acid binding 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0005326 neurotransmitter transmembrane transporter activity 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0010851 cyclase regulator activity 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0016502 nucleotide receptor activity 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0042288 MHC class I protein binding 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0043024 ribosomal small subunit binding 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0061608 nuclear import signal receptor activity 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0140939 histone H4 methyltransferase activity 1/500 20/18639 0.05 1.8639 0.419646602082083 0.820642244071629 GO:0015485 cholesterol binding 2/500 54/18639 0.037037037037037 1.38066666666667 0.427101273583278 0.826698189728418 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 3/500 89/18639 0.0337078651685393 1.25656179775281 0.428616648562684 0.826698189728418 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 3/500 89/18639 0.0337078651685393 1.25656179775281 0.428616648562684 0.826698189728418 GO:0005525 GTP binding 11/500 378/18639 0.0291005291005291 1.08480952380952 0.434849139048326 0.826698189728418 GO:0001846 opsonin binding 1/500 21/18639 0.0476190476190476 1.77514285714286 0.43523157973711 0.826698189728418 GO:0008373 sialyltransferase activity 1/500 21/18639 0.0476190476190476 1.77514285714286 0.43523157973711 0.826698189728418 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/500 21/18639 0.0476190476190476 1.77514285714286 0.43523157973711 0.826698189728418 GO:0015174 basic amino acid transmembrane transporter activity 1/500 21/18639 0.0476190476190476 1.77514285714286 0.43523157973711 0.826698189728418 GO:0036122 BMP binding 1/500 21/18639 0.0476190476190476 1.77514285714286 0.43523157973711 0.826698189728418 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/500 21/18639 0.0476190476190476 1.77514285714286 0.43523157973711 0.826698189728418 GO:0061891 calcium ion sensor activity 1/500 21/18639 0.0476190476190476 1.77514285714286 0.43523157973711 0.826698189728418 GO:0140793 histone H2AXY142 phosphatase activity 3/500 90/18639 0.0333333333333333 1.2426 0.435732453373629 0.826698189728418 GO:0098632 cell-cell adhesion mediator activity 2/500 55/18639 0.0363636363636364 1.35556363636364 0.436312933467776 0.826698189728418 GO:0016829 lyase activity 6/500 200/18639 0.03 1.11834 0.449003510335828 0.831832887905434 GO:0052689 carboxylic ester hydrolase activity 3/500 92/18639 0.0326086956521739 1.21558695652174 0.449862636464337 0.831832887905434 GO:0008093 cytoskeletal anchor activity 1/500 22/18639 0.0454545454545455 1.69445454545455 0.450398848516327 0.831832887905434 GO:0008970 phospholipase A1 activity 1/500 22/18639 0.0454545454545455 1.69445454545455 0.450398848516327 0.831832887905434 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/500 22/18639 0.0454545454545455 1.69445454545455 0.450398848516327 0.831832887905434 GO:0016881 acid-amino acid ligase activity 1/500 22/18639 0.0454545454545455 1.69445454545455 0.450398848516327 0.831832887905434 GO:0031683 G-protein beta/gamma-subunit complex binding 1/500 22/18639 0.0454545454545455 1.69445454545455 0.450398848516327 0.831832887905434 GO:0033691 sialic acid binding 1/500 22/18639 0.0454545454545455 1.69445454545455 0.450398848516327 0.831832887905434 GO:0140035 ubiquitin-like protein reader activity 1/500 22/18639 0.0454545454545455 1.69445454545455 0.450398848516327 0.831832887905434 GO:0140784 metal ion sensor activity 1/500 22/18639 0.0454545454545455 1.69445454545455 0.450398848516327 0.831832887905434 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/500 128/18639 0.03125 1.1649375 0.450576147615443 0.831832887905434 GO:0008408 3'-5' exonuclease activity 2/500 58/18639 0.0344827586206897 1.28544827586207 0.463453917249484 0.83728724764605 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/500 58/18639 0.0344827586206897 1.28544827586207 0.463453917249484 0.83728724764605 GO:0042562 hormone binding 3/500 94/18639 0.0319148936170213 1.18972340425532 0.463847135716021 0.83728724764605 GO:0003887 DNA-directed DNA polymerase activity 1/500 23/18639 0.0434782608695652 1.62078260869565 0.465159582025583 0.83728724764605 GO:0005158 insulin receptor binding 1/500 23/18639 0.0434782608695652 1.62078260869565 0.465159582025583 0.83728724764605 GO:0005212 structural constituent of eye lens 1/500 23/18639 0.0434782608695652 1.62078260869565 0.465159582025583 0.83728724764605 GO:0017134 fibroblast growth factor binding 1/500 23/18639 0.0434782608695652 1.62078260869565 0.465159582025583 0.83728724764605 GO:0042171 lysophosphatidic acid acyltransferase activity 1/500 23/18639 0.0434782608695652 1.62078260869565 0.465159582025583 0.83728724764605 GO:0070577 lysine-acetylated histone binding 1/500 23/18639 0.0434782608695652 1.62078260869565 0.465159582025583 0.83728724764605 GO:0071617 lysophospholipid acyltransferase activity 1/500 23/18639 0.0434782608695652 1.62078260869565 0.465159582025583 0.83728724764605 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/500 23/18639 0.0434782608695652 1.62078260869565 0.465159582025583 0.83728724764605 GO:0016247 channel regulator activity 5/500 168/18639 0.0297619047619048 1.10946428571429 0.470885790819364 0.842092078063237 GO:0031593 polyubiquitin modification-dependent protein binding 2/500 59/18639 0.0338983050847458 1.26366101694915 0.472329187491198 0.842092078063237 GO:0070063 RNA polymerase binding 2/500 59/18639 0.0338983050847458 1.26366101694915 0.472329187491198 0.842092078063237 GO:0004806 triacylglycerol lipase activity 1/500 24/18639 0.0416666666666667 1.55325 0.479524655563788 0.842092078063237 GO:0005540 hyaluronic acid binding 1/500 24/18639 0.0416666666666667 1.55325 0.479524655563788 0.842092078063237 GO:0015295 solute:proton symporter activity 1/500 24/18639 0.0416666666666667 1.55325 0.479524655563788 0.842092078063237 GO:0019957 C-C chemokine binding 1/500 24/18639 0.0416666666666667 1.55325 0.479524655563788 0.842092078063237 GO:0030215 semaphorin receptor binding 1/500 24/18639 0.0416666666666667 1.55325 0.479524655563788 0.842092078063237 GO:0050699 WW domain binding 1/500 24/18639 0.0416666666666667 1.55325 0.479524655563788 0.842092078063237 GO:0070840 dynein complex binding 1/500 24/18639 0.0416666666666667 1.55325 0.479524655563788 0.842092078063237 GO:0140033 acetylation-dependent protein binding 1/500 24/18639 0.0416666666666667 1.55325 0.479524655563788 0.842092078063237 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/500 60/18639 0.0333333333333333 1.2426 0.481115494193001 0.842361392294185 GO:0005516 calmodulin binding 6/500 207/18639 0.0289855072463768 1.08052173913043 0.481909660449343 0.842361392294185 GO:0016836 hydro-lyase activity 2/500 61/18639 0.0327868852459016 1.22222950819672 0.489811217438507 0.842361392294185 GO:0019905 syntaxin binding 2/500 61/18639 0.0327868852459016 1.22222950819672 0.489811217438507 0.842361392294185 GO:0031267 small GTPase binding 8/500 283/18639 0.0282685512367491 1.05379505300353 0.490544456718727 0.842361392294185 GO:0004725 protein tyrosine phosphatase activity 3/500 98/18639 0.0306122448979592 1.14116326530612 0.491333413295782 0.842361392294185 GO:0042626 ATPase-coupled transmembrane transporter activity 3/500 98/18639 0.0306122448979592 1.14116326530612 0.491333413295782 0.842361392294185 GO:0008139 nuclear localization sequence binding 1/500 25/18639 0.04 1.49112 0.493504654071341 0.842361392294185 GO:0008483 transaminase activity 1/500 25/18639 0.04 1.49112 0.493504654071341 0.842361392294185 GO:0015271 outward rectifier potassium channel activity 1/500 25/18639 0.04 1.49112 0.493504654071341 0.842361392294185 GO:0017056 structural constituent of nuclear pore 1/500 25/18639 0.04 1.49112 0.493504654071341 0.842361392294185 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/500 25/18639 0.04 1.49112 0.493504654071341 0.842361392294185 GO:0019707 protein-cysteine S-acyltransferase activity 1/500 25/18639 0.04 1.49112 0.493504654071341 0.842361392294185 GO:0042393 histone binding 7/500 247/18639 0.0283400809716599 1.05646153846154 0.495155743598311 0.843362040709381 GO:0004435 phosphatidylinositol phospholipase C activity 1/500 26/18639 0.0384615384615385 1.43376923076923 0.507109879867211 0.852719797993273 GO:0005160 transforming growth factor beta receptor binding 1/500 26/18639 0.0384615384615385 1.43376923076923 0.507109879867211 0.852719797993273 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/500 26/18639 0.0384615384615385 1.43376923076923 0.507109879867211 0.852719797993273 GO:0008143 poly(A) binding 1/500 26/18639 0.0384615384615385 1.43376923076923 0.507109879867211 0.852719797993273 GO:0008157 protein phosphatase 1 binding 1/500 26/18639 0.0384615384615385 1.43376923076923 0.507109879867211 0.852719797993273 GO:0097602 cullin family protein binding 1/500 26/18639 0.0384615384615385 1.43376923076923 0.507109879867211 0.852719797993273 GO:0019001 guanyl nucleotide binding 11/500 400/18639 0.0275 1.025145 0.50969236602361 0.853438380318604 GO:0032561 guanyl ribonucleotide binding 11/500 400/18639 0.0275 1.025145 0.50969236602361 0.853438380318604 GO:0042578 phosphoric ester hydrolase activity 10/500 363/18639 0.0275482093663912 1.02694214876033 0.511040596949792 0.85389061768826 GO:0008266 poly(U) RNA binding 1/500 27/18639 0.037037037037037 1.38066666666667 0.52035036018024 0.865793036266281 GO:0008395 steroid hydroxylase activity 1/500 27/18639 0.037037037037037 1.38066666666667 0.52035036018024 0.865793036266281 GO:0019789 SUMO transferase activity 1/500 28/18639 0.0357142857142857 1.33135714285714 0.533235854480147 0.875088840368658 GO:0036408 histone H3K14 acetyltransferase activity 1/500 28/18639 0.0357142857142857 1.33135714285714 0.533235854480147 0.875088840368658 GO:0046966 nuclear thyroid hormone receptor binding 1/500 28/18639 0.0357142857142857 1.33135714285714 0.533235854480147 0.875088840368658 GO:0051537 2 iron, 2 sulfur cluster binding 1/500 28/18639 0.0357142857142857 1.33135714285714 0.533235854480147 0.875088840368658 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/500 28/18639 0.0357142857142857 1.33135714285714 0.533235854480147 0.875088840368658 GO:0097718 disordered domain specific binding 1/500 28/18639 0.0357142857142857 1.33135714285714 0.533235854480147 0.875088840368658 GO:0016500 protein-hormone receptor activity 2/500 67/18639 0.0298507462686567 1.11277611940299 0.540010702582798 0.875088840368658 GO:0008013 beta-catenin binding 3/500 106/18639 0.0283018867924528 1.05503773584906 0.544107895236762 0.875088840368658 GO:0003785 actin monomer binding 1/500 29/18639 0.0344827586206897 1.28544827586207 0.545775861613559 0.875088840368658 GO:0004181 metallocarboxypeptidase activity 1/500 29/18639 0.0344827586206897 1.28544827586207 0.545775861613559 0.875088840368658 GO:0010484 histone H3 acetyltransferase activity 1/500 29/18639 0.0344827586206897 1.28544827586207 0.545775861613559 0.875088840368658 GO:0016417 S-acyltransferase activity 1/500 29/18639 0.0344827586206897 1.28544827586207 0.545775861613559 0.875088840368658 GO:0035250 UDP-galactosyltransferase activity 1/500 29/18639 0.0344827586206897 1.28544827586207 0.545775861613559 0.875088840368658 GO:0043236 laminin binding 1/500 29/18639 0.0344827586206897 1.28544827586207 0.545775861613559 0.875088840368658 GO:0099604 ligand-gated calcium channel activity 1/500 29/18639 0.0344827586206897 1.28544827586207 0.545775861613559 0.875088840368658 GO:0032934 sterol binding 2/500 68/18639 0.0294117647058824 1.09641176470588 0.548038788462861 0.875088840368658 GO:0008237 metallopeptidase activity 5/500 184/18639 0.0271739130434783 1.01298913043478 0.551262089499669 0.875088840368658 GO:0002039 p53 binding 2/500 69/18639 0.0289855072463768 1.08052173913043 0.555968202189693 0.875088840368658 GO:0008080 N-acetyltransferase activity 2/500 69/18639 0.0289855072463768 1.08052173913043 0.555968202189693 0.875088840368658 GO:1901981 phosphatidylinositol phosphate binding 5/500 185/18639 0.027027027027027 1.00751351351351 0.556093312141707 0.875088840368658 GO:0005496 steroid binding 3/500 108/18639 0.0277777777777778 1.0355 0.55679810239325 0.875088840368658 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/500 30/18639 0.0333333333333333 1.2426 0.557979626750218 0.875088840368658 GO:0008187 poly-pyrimidine tract binding 1/500 30/18639 0.0333333333333333 1.2426 0.557979626750218 0.875088840368658 GO:0016769 transferase activity, transferring nitrogenous groups 1/500 30/18639 0.0333333333333333 1.2426 0.557979626750218 0.875088840368658 GO:0031210 phosphatidylcholine binding 1/500 30/18639 0.0333333333333333 1.2426 0.557979626750218 0.875088840368658 GO:0043995 histone H4K5 acetyltransferase activity 1/500 30/18639 0.0333333333333333 1.2426 0.557979626750218 0.875088840368658 GO:0043996 histone H4K8 acetyltransferase activity 1/500 30/18639 0.0333333333333333 1.2426 0.557979626750218 0.875088840368658 GO:0043997 histone H4K12 acetyltransferase activity 1/500 30/18639 0.0333333333333333 1.2426 0.557979626750218 0.875088840368658 GO:0048019 receptor antagonist activity 1/500 30/18639 0.0333333333333333 1.2426 0.557979626750218 0.875088840368658 GO:0017147 Wnt-protein binding 1/500 31/18639 0.032258064516129 1.20251612903226 0.56985614814443 0.890189485858754 GO:0047499 calcium-independent phospholipase A2 activity 1/500 31/18639 0.032258064516129 1.20251612903226 0.56985614814443 0.890189485858754 GO:1902936 phosphatidylinositol bisphosphate binding 3/500 111/18639 0.027027027027027 1.00751351351351 0.575431113741371 0.895875551563391 GO:0008378 galactosyltransferase activity 1/500 32/18639 0.03125 1.1649375 0.581414183716645 0.895875551563391 GO:0022884 macromolecule transmembrane transporter activity 1/500 32/18639 0.03125 1.1649375 0.581414183716645 0.895875551563391 GO:0031369 translation initiation factor binding 1/500 32/18639 0.03125 1.1649375 0.581414183716645 0.895875551563391 GO:0042910 xenobiotic transmembrane transporter activity 1/500 32/18639 0.03125 1.1649375 0.581414183716645 0.895875551563391 GO:0070717 poly-purine tract binding 1/500 32/18639 0.03125 1.1649375 0.581414183716645 0.895875551563391 GO:0140142 nucleocytoplasmic carrier activity 1/500 32/18639 0.03125 1.1649375 0.581414183716645 0.895875551563391 GO:0000287 magnesium ion binding 6/500 230/18639 0.0260869565217391 0.972469565217391 0.584807736939992 0.899354810983445 GO:0019956 chemokine binding 1/500 33/18639 0.0303030303030303 1.12963636363636 0.59266225745995 0.906155420672356 GO:0071889 14-3-3 protein binding 1/500 33/18639 0.0303030303030303 1.12963636363636 0.59266225745995 0.906155420672356 GO:0140416 transcription regulator inhibitor activity 1/500 33/18639 0.0303030303030303 1.12963636363636 0.59266225745995 0.906155420672356 GO:0031491 nucleosome binding 2/500 74/18639 0.027027027027027 1.00751351351351 0.594121248475191 0.906635893626881 GO:0008376 acetylgalactosaminyltransferase activity 1/500 34/18639 0.0294117647058824 1.09641176470588 0.603608665676118 0.911557965990071 GO:0015035 protein-disulfide reductase activity 1/500 34/18639 0.0294117647058824 1.09641176470588 0.603608665676118 0.911557965990071 GO:0016831 carboxy-lyase activity 1/500 34/18639 0.0294117647058824 1.09641176470588 0.603608665676118 0.911557965990071 GO:0019825 oxygen binding 1/500 34/18639 0.0294117647058824 1.09641176470588 0.603608665676118 0.911557965990071 GO:0030332 cyclin binding 1/500 34/18639 0.0294117647058824 1.09641176470588 0.603608665676118 0.911557965990071 GO:0015294 solute:monoatomic cation symporter activity 3/500 116/18639 0.0258620689655172 0.964086206896552 0.605376141855746 0.911557965990071 GO:1990782 protein tyrosine kinase binding 3/500 117/18639 0.0256410256410256 0.955846153846154 0.611194640531671 0.911557965990071 GO:0016758 hexosyltransferase activity 5/500 197/18639 0.0253807106598985 0.946142131979695 0.611949414338725 0.911557965990071 GO:0051020 GTPase binding 8/500 315/18639 0.0253968253968254 0.946742857142857 0.612091548960802 0.911557965990071 GO:0004623 phospholipase A2 activity 1/500 35/18639 0.0285714285714286 1.06508571428571 0.614261483045747 0.911557965990071 GO:0010485 histone H4 acetyltransferase activity 1/500 35/18639 0.0285714285714286 1.06508571428571 0.614261483045747 0.911557965990071 GO:0034061 DNA polymerase activity 1/500 35/18639 0.0285714285714286 1.06508571428571 0.614261483045747 0.911557965990071 GO:0019199 transmembrane receptor protein kinase activity 2/500 78/18639 0.0256410256410256 0.955846153846154 0.622841320245882 0.911557965990071 GO:0000993 RNA polymerase II complex binding 1/500 36/18639 0.0277777777777778 1.0355 0.624628568536885 0.911557965990071 GO:0004033 aldo-keto reductase (NADPH) activity 1/500 36/18639 0.0277777777777778 1.0355 0.624628568536885 0.911557965990071 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/500 36/18639 0.0277777777777778 1.0355 0.624628568536885 0.911557965990071 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/500 36/18639 0.0277777777777778 1.0355 0.624628568536885 0.911557965990071 GO:0016409 palmitoyltransferase activity 1/500 36/18639 0.0277777777777778 1.0355 0.624628568536885 0.911557965990071 GO:0099106 ion channel regulator activity 4/500 160/18639 0.025 0.93195 0.625584470551614 0.911557965990071 GO:0016835 carbon-oxygen lyase activity 2/500 79/18639 0.0253164556962025 0.943746835443038 0.629771442551649 0.911557965990071 GO:0046332 SMAD binding 2/500 79/18639 0.0253164556962025 0.943746835443038 0.629771442551649 0.911557965990071 GO:0004540 RNA nuclease activity 3/500 121/18639 0.0247933884297521 0.924247933884298 0.633889511710229 0.911557965990071 GO:0015108 chloride transmembrane transporter activity 3/500 121/18639 0.0247933884297521 0.924247933884298 0.633889511710229 0.911557965990071 GO:0030280 structural constituent of skin epidermis 1/500 37/18639 0.027027027027027 1.00751351351351 0.634717571156438 0.911557965990071 GO:0000049 tRNA binding 2/500 80/18639 0.025 0.93195 0.636602080301603 0.911557965990071 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 3/500 122/18639 0.0245901639344262 0.916672131147541 0.63941731052009 0.911557965990071 GO:0015101 organic cation transmembrane transporter activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0030971 receptor tyrosine kinase binding 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0033192 calmodulin-dependent protein phosphatase activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0140791 histone H2AXS140 phosphatase activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/500 81/18639 0.0246913580246914 0.920444444444444 0.643333572867667 0.911557965990071 GO:0005109 frizzled binding 1/500 38/18639 0.0263157894736842 0.981 0.644535935548535 0.911557965990071 GO:0005501 retinoid binding 1/500 38/18639 0.0263157894736842 0.981 0.644535935548535 0.911557965990071 GO:0019840 isoprenoid binding 1/500 38/18639 0.0263157894736842 0.981 0.644535935548535 0.911557965990071 GO:0042887 amide transmembrane transporter activity 1/500 38/18639 0.0263157894736842 0.981 0.644535935548535 0.911557965990071 GO:0043531 ADP binding 1/500 38/18639 0.0263157894736842 0.981 0.644535935548535 0.911557965990071 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/500 82/18639 0.024390243902439 0.909219512195122 0.649966312936096 0.915966761290726 GO:0033549 MAP kinase phosphatase activity 2/500 82/18639 0.024390243902439 0.909219512195122 0.649966312936096 0.915966761290726 GO:0000217 DNA secondary structure binding 1/500 39/18639 0.0256410256410256 0.955846153846154 0.654090907443903 0.918510635985055 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/500 39/18639 0.0256410256410256 0.955846153846154 0.654090907443903 0.918510635985055 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/500 83/18639 0.0240963855421687 0.898265060240964 0.65650074341453 0.920262988998775 GO:0017018 myosin phosphatase activity 2/500 84/18639 0.0238095238095238 0.887571428571429 0.66293735446605 0.921925935575981 GO:0004177 aminopeptidase activity 1/500 40/18639 0.025 0.93195 0.663389538964227 0.921925935575981 GO:0030331 nuclear estrogen receptor binding 1/500 40/18639 0.025 0.93195 0.663389538964227 0.921925935575981 GO:0050997 quaternary ammonium group binding 1/500 40/18639 0.025 0.93195 0.663389538964227 0.921925935575981 GO:0004518 nuclease activity 5/500 209/18639 0.0239234449760766 0.891818181818182 0.663507302119077 0.921925935575981 GO:0042826 histone deacetylase binding 3/500 127/18639 0.0236220472440945 0.880582677165354 0.666173732465313 0.924009800547334 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/500 41/18639 0.024390243902439 0.909219512195122 0.672438693785341 0.929444058425812 GO:0042169 SH2 domain binding 1/500 41/18639 0.024390243902439 0.909219512195122 0.672438693785341 0.929444058425812 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 2/500 86/18639 0.0232558139534884 0.86693023255814 0.675519298274835 0.930137200287755 GO:0050660 flavin adenine dinucleotide binding 2/500 86/18639 0.0232558139534884 0.86693023255814 0.675519298274835 0.930137200287755 GO:0035591 signaling adaptor activity 3/500 129/18639 0.0232558139534884 0.86693023255814 0.676463418391095 0.930137200287755 GO:0004402 histone acetyltransferase activity 1/500 42/18639 0.0238095238095238 0.887571428571429 0.68124505216298 0.930251864332897 GO:0031492 nucleosomal DNA binding 1/500 42/18639 0.0238095238095238 0.887571428571429 0.68124505216298 0.930251864332897 GO:0035198 miRNA binding 1/500 42/18639 0.0238095238095238 0.887571428571429 0.68124505216298 0.930251864332897 GO:0043175 RNA polymerase core enzyme binding 1/500 42/18639 0.0238095238095238 0.887571428571429 0.68124505216298 0.930251864332897 GO:0022804 active transmembrane transporter activity 11/500 457/18639 0.0240700218818381 0.89728227571116 0.685242267002701 0.934099613538965 GO:0016651 oxidoreductase activity, acting on NAD(P)H 2/500 88/18639 0.0227272727272727 0.847227272727273 0.687716905639129 0.935502691324018 GO:0008200 ion channel inhibitor activity 1/500 43/18639 0.0232558139534884 0.86693023255814 0.689815115824781 0.935502691324018 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/500 43/18639 0.0232558139534884 0.86693023255814 0.689815115824781 0.935502691324018 GO:0001223 transcription coactivator binding 1/500 44/18639 0.0227272727272727 0.847227272727273 0.698155212732052 0.937184624548788 GO:0016248 channel inhibitor activity 1/500 44/18639 0.0227272727272727 0.847227272727273 0.698155212732052 0.937184624548788 GO:0016790 thiolester hydrolase activity 1/500 44/18639 0.0227272727272727 0.847227272727273 0.698155212732052 0.937184624548788 GO:0019205 nucleobase-containing compound kinase activity 1/500 44/18639 0.0227272727272727 0.847227272727273 0.698155212732052 0.937184624548788 GO:0030547 signaling receptor inhibitor activity 1/500 44/18639 0.0227272727272727 0.847227272727273 0.698155212732052 0.937184624548788 GO:0043014 alpha-tubulin binding 1/500 44/18639 0.0227272727272727 0.847227272727273 0.698155212732052 0.937184624548788 GO:0051087 protein-folding chaperone binding 3/500 134/18639 0.0223880597014925 0.834582089552239 0.701157479801792 0.939622206434888 GO:0140789 histone phosphatase activity 3/500 136/18639 0.0220588235294118 0.822308823529412 0.710625360983206 0.942791950830205 GO:0043178 alcohol binding 2/500 92/18639 0.0217391304347826 0.810391304347826 0.71098101105948 0.942791950830205 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/500 46/18639 0.0217391304347826 0.810391304347826 0.714169976983294 0.942791950830205 GO:0030276 clathrin binding 1/500 46/18639 0.0217391304347826 0.810391304347826 0.714169976983294 0.942791950830205 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4/500 181/18639 0.0220994475138122 0.82382320441989 0.71917085370428 0.942791950830205 GO:0001784 phosphotyrosine residue binding 1/500 47/18639 0.0212765957446809 0.793148936170213 0.721856472519698 0.942791950830205 GO:0061733 protein-lysine-acetyltransferase activity 1/500 47/18639 0.0212765957446809 0.793148936170213 0.721856472519698 0.942791950830205 GO:0140938 histone H3 methyltransferase activity 1/500 47/18639 0.0212765957446809 0.793148936170213 0.721856472519698 0.942791950830205 GO:0016410 N-acyltransferase activity 2/500 94/18639 0.0212765957446809 0.793148936170213 0.722059667517236 0.942791950830205 GO:0140767 enzyme-substrate adaptor activity 3/500 139/18639 0.0215827338129496 0.804561151079137 0.724392458210833 0.942791950830205 GO:0032266 phosphatidylinositol-3-phosphate binding 1/500 48/18639 0.0208333333333333 0.776625 0.729336666352537 0.942791950830205 GO:0016407 acetyltransferase activity 2/500 96/18639 0.0208333333333333 0.776625 0.73277817249573 0.942791950830205 GO:0005004 GPI-linked ephrin receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0005008 hepatocyte growth factor receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0005009 insulin receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0005011 macrophage colony-stimulating factor receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0005020 stem cell factor receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0008288 boss receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0036332 placental growth factor receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0038062 protein tyrosine kinase collagen receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0060175 brain-derived neurotrophic factor receptor activity 1/500 49/18639 0.0204081632653061 0.760775510204082 0.736616084717538 0.942791950830205 GO:0005096 GTPase activator activity 6/500 271/18639 0.022140221402214 0.825343173431734 0.737990279675784 0.942791950830205 GO:0005085 guanyl-nucleotide exchange factor activity 5/500 230/18639 0.0217391304347826 0.810391304347826 0.742453008924065 0.942791950830205 GO:0005006 epidermal growth factor receptor activity 1/500 50/18639 0.02 0.74556 0.743700106107599 0.942791950830205 GO:0005007 fibroblast growth factor receptor activity 1/500 50/18639 0.02 0.74556 0.743700106107599 0.942791950830205 GO:0005017 platelet-derived growth factor receptor activity 1/500 50/18639 0.02 0.74556 0.743700106107599 0.942791950830205 GO:0005019 platelet-derived growth factor beta-receptor activity 1/500 50/18639 0.02 0.74556 0.743700106107599 0.942791950830205 GO:0016791 phosphatase activity 6/500 273/18639 0.021978021978022 0.819296703296703 0.744308396906408 0.942791950830205 GO:0019903 protein phosphatase binding 3/500 144/18639 0.0208333333333333 0.776625 0.746194226030862 0.942791950830205 GO:0046943 carboxylic acid transmembrane transporter activity 4/500 188/18639 0.0212765957446809 0.793148936170213 0.746232866496804 0.942791950830205 GO:0005342 organic acid transmembrane transporter activity 4/500 189/18639 0.0211640211640212 0.788952380952381 0.74993180358566 0.942791950830205 GO:0005010 insulin-like growth factor receptor activity 1/500 51/18639 0.0196078431372549 0.730941176470588 0.750593965214931 0.942791950830205 GO:0005021 vascular endothelial growth factor receptor activity 1/500 51/18639 0.0196078431372549 0.730941176470588 0.750593965214931 0.942791950830205 GO:0005030 neurotrophin receptor activity 1/500 51/18639 0.0196078431372549 0.730941176470588 0.750593965214931 0.942791950830205 GO:0005048 signal sequence binding 1/500 51/18639 0.0196078431372549 0.730941176470588 0.750593965214931 0.942791950830205 GO:0016597 amino acid binding 1/500 51/18639 0.0196078431372549 0.730941176470588 0.750593965214931 0.942791950830205 GO:0019902 phosphatase binding 4/500 190/18639 0.0210526315789474 0.7848 0.753589356815032 0.942791950830205 GO:0015293 symporter activity 3/500 146/18639 0.0205479452054795 0.765986301369863 0.754521374708682 0.942791950830205 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/500 52/18639 0.0192307692307692 0.716884615384615 0.75730275676822 0.942791950830205 GO:0030159 signaling receptor complex adaptor activity 1/500 52/18639 0.0192307692307692 0.716884615384615 0.75730275676822 0.942791950830205 GO:0001217 DNA-binding transcription repressor activity 6/500 278/18639 0.0215827338129496 0.804561151079137 0.759623004058591 0.942791950830205 GO:0004864 protein phosphatase inhibitor activity 1/500 53/18639 0.0188679245283019 0.703358490566038 0.763831439267596 0.942791950830205 GO:0005003 ephrin receptor activity 1/500 53/18639 0.0188679245283019 0.703358490566038 0.763831439267596 0.942791950830205 GO:0005005 transmembrane-ephrin receptor activity 1/500 53/18639 0.0188679245283019 0.703358490566038 0.763831439267596 0.942791950830205 GO:0005246 calcium channel regulator activity 1/500 53/18639 0.0188679245283019 0.703358490566038 0.763831439267596 0.942791950830205 GO:0017046 peptide hormone binding 1/500 53/18639 0.0188679245283019 0.703358490566038 0.763831439267596 0.942791950830205 GO:0034212 protein N-acetyltransferase activity 1/500 53/18639 0.0188679245283019 0.703358490566038 0.763831439267596 0.942791950830205 GO:0038064 collagen receptor activity 1/500 53/18639 0.0188679245283019 0.703358490566038 0.763831439267596 0.942791950830205 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/500 53/18639 0.0188679245283019 0.703358490566038 0.763831439267596 0.942791950830205 GO:0008509 monoatomic anion transmembrane transporter activity 3/500 149/18639 0.0201342281879195 0.750563758389262 0.766598618424671 0.942791950830205 GO:0004722 protein serine/threonine phosphatase activity 2/500 103/18639 0.0194174757281553 0.723844660194175 0.767560117529035 0.942791950830205 GO:0003925 G protein activity 1/500 54/18639 0.0185185185185185 0.690333333333333 0.77018483862013 0.942791950830205 GO:0050661 NADP binding 1/500 54/18639 0.0185185185185185 0.690333333333333 0.77018483862013 0.942791950830205 GO:0051287 NAD binding 1/500 54/18639 0.0185185185185185 0.690333333333333 0.77018483862013 0.942791950830205 GO:0140463 chromatin-protein adaptor activity 1/500 54/18639 0.0185185185185185 0.690333333333333 0.77018483862013 0.942791950830205 GO:0035091 phosphatidylinositol binding 6/500 284/18639 0.0211267605633803 0.78756338028169 0.777099829169228 0.949788680095723 GO:0004497 monooxygenase activity 2/500 106/18639 0.0188679245283019 0.703358490566038 0.781221884730068 0.953305360232098 GO:0019212 phosphatase inhibitor activity 1/500 56/18639 0.0178571428571429 0.665678571428571 0.782384449685434 0.953305360232098 GO:0061980 regulatory RNA binding 1/500 58/18639 0.0172413793103448 0.642724137931034 0.79393767749257 0.965896529299716 GO:0045309 protein phosphorylated amino acid binding 1/500 59/18639 0.0169491525423729 0.631830508474576 0.79948265145811 0.971150705452183 GO:0001098 basal transcription machinery binding 1/500 60/18639 0.0166666666666667 0.6213 0.804878704971078 0.973227380667319 GO:0001099 basal RNA polymerase II transcription machinery binding 1/500 60/18639 0.0166666666666667 0.6213 0.804878704971078 0.973227380667319 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/500 60/18639 0.0166666666666667 0.6213 0.804878704971078 0.973227380667319 GO:0015631 tubulin binding 8/500 385/18639 0.0207792207792208 0.774607792207792 0.814347480563457 0.982754960939617 GO:0015179 L-amino acid transmembrane transporter activity 1/500 62/18639 0.0161290322580645 0.601258064516129 0.815239910779455 0.982754960939617 GO:0001221 transcription coregulator binding 2/500 115/18639 0.0173913043478261 0.648313043478261 0.818062573981719 0.984658903637571 GO:0003713 transcription coactivator activity 5/500 256/18639 0.01953125 0.7280859375 0.820204003244504 0.985738346843168 GO:0015103 inorganic anion transmembrane transporter activity 3/500 165/18639 0.0181818181818182 0.677781818181818 0.823048763238142 0.987658515885771 GO:0008235 metalloexopeptidase activity 1/500 66/18639 0.0151515151515152 0.564818181818182 0.834343915984533 0.998292866280905 GO:0003730 mRNA 3'-UTR binding 5/500 262/18639 0.0190839694656489 0.711412213740458 0.835181849216159 0.998292866280905 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/500 67/18639 0.0149253731343284 0.556388059701493 0.838803510126983 0.998292866280905 GO:0042054 histone methyltransferase activity 1/500 67/18639 0.0149253731343284 0.556388059701493 0.838803510126983 0.998292866280905 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/500 122/18639 0.0163934426229508 0.611114754098361 0.842772966737495 0.998292866280905 GO:0003777 microtubule motor activity 1/500 68/18639 0.0147058823529412 0.548205882352941 0.843143282092119 0.998292866280905 GO:0030145 manganese ion binding 1/500 68/18639 0.0147058823529412 0.548205882352941 0.843143282092119 0.998292866280905 GO:1990841 promoter-specific chromatin binding 1/500 68/18639 0.0147058823529412 0.548205882352941 0.843143282092119 0.998292866280905 GO:0016279 protein-lysine N-methyltransferase activity 1/500 69/18639 0.0144927536231884 0.540260869565217 0.847366445031861 0.998292866280905 GO:0030695 GTPase regulator activity 10/500 489/18639 0.0204498977505112 0.762331288343558 0.84882376560131 0.998292866280905 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 5/500 268/18639 0.0186567164179104 0.695485074626866 0.849126147990543 0.998292866280905 GO:0060589 nucleoside-triphosphatase regulator activity 10/500 490/18639 0.0204081632653061 0.760775510204082 0.850517263520842 0.998292866280905 GO:0008514 organic anion transmembrane transporter activity 5/500 269/18639 0.0185873605947955 0.692899628252788 0.851352741028863 0.998292866280905 GO:0016278 lysine N-methyltransferase activity 1/500 70/18639 0.0142857142857143 0.532542857142857 0.851476126102624 0.998292866280905 GO:0016782 transferase activity, transferring sulphur-containing groups 1/500 70/18639 0.0142857142857143 0.532542857142857 0.851476126102624 0.998292866280905 GO:0004721 phosphoprotein phosphatase activity 3/500 175/18639 0.0171428571428571 0.639051428571429 0.852078254552894 0.998292866280905 GO:0140299 molecular sensor activity 1/500 71/18639 0.0140845070422535 0.525042253521127 0.855475368762363 0.999588144403624 GO:0004519 endonuclease activity 2/500 127/18639 0.015748031496063 0.587055118110236 0.858517948886555 0.999588144403624 GO:0031490 chromatin DNA binding 2/500 128/18639 0.015625 0.58246875 0.861488899273616 0.999588144403624 GO:0004521 RNA endonuclease activity 1/500 73/18639 0.0136986301369863 0.510657534246575 0.8631543075435 0.999588144403624 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/500 73/18639 0.0136986301369863 0.510657534246575 0.8631543075435 0.999588144403624 GO:0008017 microtubule binding 5/500 276/18639 0.0181159420289855 0.675326086956522 0.866186486575688 0.999588144403624 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4/500 229/18639 0.0174672489082969 0.651144104803493 0.866228315828108 0.999588144403624 GO:0031072 heat shock protein binding 2/500 131/18639 0.0152671755725191 0.569129770992366 0.870062447238902 0.999588144403624 GO:0003725 double-stranded RNA binding 1/500 75/18639 0.0133333333333333 0.49704 0.870426018552751 0.999588144403624 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2/500 132/18639 0.0151515151515152 0.564818181818182 0.872810238605456 0.999588144403624 GO:0017022 myosin binding 1/500 76/18639 0.0131578947368421 0.4905 0.87391594479298 0.999588144403624 GO:0051536 iron-sulfur cluster binding 1/500 76/18639 0.0131578947368421 0.4905 0.87391594479298 0.999588144403624 GO:0003724 RNA helicase activity 1/500 77/18639 0.012987012987013 0.48412987012987 0.877312056822475 0.999588144403624 GO:0051540 metal cluster binding 1/500 77/18639 0.012987012987013 0.48412987012987 0.877312056822475 0.999588144403624 GO:0044325 transmembrane transporter binding 2/500 136/18639 0.0147058823529412 0.548205882352941 0.883274945943076 0.999588144403624 GO:0008186 ATP-dependent activity, acting on RNA 1/500 79/18639 0.0126582278481013 0.471873417721519 0.883832838622076 0.999588144403624 GO:0015370 solute:sodium symporter activity 1/500 79/18639 0.0126582278481013 0.471873417721519 0.883832838622076 0.999588144403624 GO:0001618 virus receptor activity 1/500 81/18639 0.0123456790123457 0.460222222222222 0.890007701504759 0.999588144403624 GO:0140097 catalytic activity, acting on DNA 6/500 336/18639 0.0178571428571429 0.665678571428571 0.890557036434249 0.999588144403624 GO:0140272 exogenous protein binding 1/500 82/18639 0.0121951219512195 0.454609756097561 0.892971175437706 0.999588144403624 GO:0005254 chloride channel activity 1/500 83/18639 0.0120481927710843 0.449132530120482 0.895854961194086 0.999588144403624 GO:0030165 PDZ domain binding 1/500 83/18639 0.0120481927710843 0.449132530120482 0.895854961194086 0.999588144403624 GO:0004674 protein serine/threonine kinase activity 8/500 433/18639 0.0184757505773672 0.688739030023095 0.898202116270563 0.999588144403624 GO:0035402 histone H3T11 kinase activity 4/500 247/18639 0.0161943319838057 0.603692307692308 0.901192958037918 0.999588144403624 GO:0004679 AMP-activated protein kinase activity 4/500 248/18639 0.0161290322580645 0.601258064516129 0.902875530670237 0.999588144403624 GO:0140104 molecular carrier activity 4/500 249/18639 0.0160642570281124 0.598843373493976 0.904532772075877 0.999588144403624 GO:0003727 single-stranded RNA binding 1/500 89/18639 0.0112359550561798 0.41885393258427 0.911600062922847 0.999588144403624 GO:0045182 translation regulator activity 6/500 356/18639 0.0168539325842697 0.628280898876404 0.91876003853901 0.999588144403624 GO:0051219 phosphoprotein binding 1/500 93/18639 0.010752688172043 0.400838709677419 0.920753291421066 0.999588144403624 GO:0008276 protein methyltransferase activity 1/500 95/18639 0.0105263157894737 0.3924 0.924968784912495 0.999588144403624 GO:0030594 neurotransmitter receptor activity 1/500 97/18639 0.0103092783505155 0.384309278350515 0.928960461690222 0.999588144403624 GO:0005249 voltage-gated potassium channel activity 1/500 98/18639 0.0102040816326531 0.380387755102041 0.930876100194962 0.999588144403624 GO:0008170 N-methyltransferase activity 1/500 98/18639 0.0102040816326531 0.380387755102041 0.930876100194962 0.999588144403624 GO:0015079 potassium ion transmembrane transporter activity 2/500 160/18639 0.0125 0.465975 0.931031989894962 0.999588144403624 GO:0015171 amino acid transmembrane transporter activity 1/500 102/18639 0.00980392156862745 0.365470588235294 0.938036755952022 0.999588144403624 GO:0005253 monoatomic anion channel activity 1/500 103/18639 0.00970873786407767 0.361922330097087 0.939708095544404 0.999588144403624 GO:0016874 ligase activity 2/500 167/18639 0.0119760479041916 0.446443113772455 0.941030748701465 0.999588144403624 GO:0019888 protein phosphatase regulator activity 1/500 107/18639 0.00934579439252336 0.348392523364486 0.945955447145454 0.999588144403624 GO:0004843 cysteine-type deubiquitinase activity 1/500 108/18639 0.00925925925925926 0.345166666666667 0.947413588545587 0.999588144403624 GO:0015291 secondary active transmembrane transporter activity 4/500 287/18639 0.0139372822299652 0.519554006968641 0.951532575597212 0.999588144403624 GO:0017124 SH3 domain binding 1/500 115/18639 0.00869565217391304 0.32415652173913 0.956578323681172 0.999588144403624 GO:0035401 histone H3Y41 kinase activity 1/500 115/18639 0.00869565217391304 0.32415652173913 0.956578323681172 0.999588144403624 GO:0101005 deubiquitinase activity 1/500 115/18639 0.00869565217391304 0.32415652173913 0.956578323681172 0.999588144403624 GO:0140801 histone H2AXY142 kinase activity 1/500 115/18639 0.00869565217391304 0.32415652173913 0.956578323681172 0.999588144403624 GO:0019208 phosphatase regulator activity 1/500 117/18639 0.00854700854700855 0.318615384615385 0.95889082625159 0.999588144403624 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 3/500 243/18639 0.0123456790123457 0.460222222222222 0.960344130892971 0.999588144403624 GO:0004676 3-phosphoinositide-dependent protein kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0004711 ribosomal protein S6 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0035175 histone H3S10 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0035979 histone H2AXS139 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0044022 histone H3S28 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0044023 histone H4S1 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0044024 histone H2AS1 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0044025 histone H2BS14 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0072354 histone H3T3 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0072371 histone H2AS121 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0072518 Rho-dependent protein serine/threonine kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0140823 histone H2BS36 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0140855 histone H3S57 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0140995 histone H2A kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0140997 histone H4 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0140998 histone H2B kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:1990244 histone H2AT120 kinase activity 3/500 245/18639 0.0122448979591837 0.456465306122449 0.961931100031163 0.999588144403624 GO:0004677 DNA-dependent protein kinase activity 3/500 246/18639 0.0121951219512195 0.454609756097561 0.962702042571689 0.999588144403624 GO:0140857 histone H3T45 kinase activity 3/500 246/18639 0.0121951219512195 0.454609756097561 0.962702042571689 0.999588144403624 GO:0035403 histone H3T6 kinase activity 3/500 247/18639 0.0121457489878543 0.452769230769231 0.96345830180776 0.999588144403624 GO:0140996 histone H3 kinase activity 5/500 357/18639 0.0140056022408964 0.522100840336135 0.964712616554423 0.999588144403624 GO:0005267 potassium channel activity 1/500 124/18639 0.00806451612903226 0.300629032258065 0.966058516358413 0.999588144403624 GO:0035173 histone kinase activity 5/500 360/18639 0.0138888888888889 0.51775 0.966532071363058 0.999588144403624 GO:0106310 protein serine kinase activity 5/500 361/18639 0.0138504155124654 0.516315789473684 0.967119100897064 0.999588144403624 GO:0019783 ubiquitin-like protein peptidase activity 1/500 127/18639 0.0078740157480315 0.293527559055118 0.968734849818968 0.999588144403624 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/500 130/18639 0.00769230769230769 0.286753846153846 0.971200539294505 0.999588144403624 GO:0046982 protein heterodimerization activity 5/500 369/18639 0.013550135501355 0.505121951219512 0.9714845624535 0.999588144403624 GO:0005262 calcium channel activity 1/500 131/18639 0.00763358778625954 0.284564885496183 0.97197852461801 0.999588144403624 GO:0016779 nucleotidyltransferase activity 1/500 136/18639 0.00735294117647059 0.274102941176471 0.975564882177098 0.999588144403624 GO:0099094 ligand-gated monoatomic cation channel activity 1/500 136/18639 0.00735294117647059 0.274102941176471 0.975564882177098 0.999588144403624 GO:0004713 protein tyrosine kinase activity 1/500 140/18639 0.00714285714285714 0.266271428571429 0.978101142561445 0.999588144403624 GO:0001216 DNA-binding transcription activator activity 7/500 491/18639 0.0142566191446029 0.531458248472505 0.979158338817704 0.999588144403624 GO:0022843 voltage-gated monoatomic cation channel activity 1/500 143/18639 0.00699300699300699 0.260685314685315 0.979829350938839 0.999588144403624 GO:0016741 transferase activity, transferring one-carbon groups 2/500 215/18639 0.00930232558139535 0.346772093023256 0.980454758348539 0.999588144403624 GO:0015085 calcium ion transmembrane transporter activity 1/500 147/18639 0.00680272108843537 0.253591836734694 0.981923737909223 0.999588144403624 GO:0000510 H3-H4 histone complex chaperone activity 1/500 151/18639 0.00662251655629139 0.24687417218543 0.983801047058975 0.999588144403624 GO:0140584 chromatin extrusion motor activity 1/500 151/18639 0.00662251655629139 0.24687417218543 0.983801047058975 0.999588144403624 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 1/500 151/18639 0.00662251655629139 0.24687417218543 0.983801047058975 0.999588144403624 GO:0140849 ATP-dependent H2AZ histone chaperone activity 1/500 151/18639 0.00662251655629139 0.24687417218543 0.983801047058975 0.999588144403624 GO:0015616 DNA translocase activity 1/500 152/18639 0.00657894736842105 0.24525 0.984239140766813 0.999588144403624 GO:0140674 ATP-dependent histone chaperone activity 1/500 152/18639 0.00657894736842105 0.24525 0.984239140766813 0.999588144403624 GO:0003774 cytoskeletal motor activity 1/500 153/18639 0.0065359477124183 0.243647058823529 0.984665409475451 0.999588144403624 GO:0061775 cohesin loader activity 1/500 153/18639 0.0065359477124183 0.243647058823529 0.984665409475451 0.999588144403624 GO:0004386 helicase activity 1/500 155/18639 0.00645161290322581 0.240503225806452 0.985483737559245 0.999588144403624 GO:0140658 ATP-dependent chromatin remodeler activity 1/500 158/18639 0.00632911392405063 0.235936708860759 0.986630232545479 0.999588144403624 GO:0141003 histone H2AX kinase activity 4/500 354/18639 0.0112994350282486 0.421220338983051 0.986652243878872 0.999588144403624 GO:0003689 DNA clamp loader activity 1/500 160/18639 0.00625 0.2329875 0.987343898533491 0.999588144403624 GO:0015081 sodium ion transmembrane transporter activity 1/500 164/18639 0.00609756097560976 0.22730487804878 0.988659184275206 0.999588144403624 GO:0140713 histone chaperone activity 1/500 164/18639 0.00609756097560976 0.22730487804878 0.988659184275206 0.999588144403624 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/500 167/18639 0.00598802395209581 0.223221556886228 0.989555306795024 0.999588144403624 GO:0019787 ubiquitin-like protein transferase activity 6/500 479/18639 0.0125260960334029 0.466947807933194 0.989686801760989 0.999588144403624 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 6/500 484/18639 0.012396694214876 0.462123966942149 0.990583102893419 0.999588144403624 GO:0005244 voltage-gated monoatomic ion channel activity 1/500 173/18639 0.00578034682080925 0.215479768786127 0.991141079293902 0.999588144403624 GO:0022832 voltage-gated channel activity 1/500 175/18639 0.00571428571428571 0.213017142857143 0.991614339259684 0.999588144403624 GO:0016755 aminoacyltransferase activity 6/500 496/18639 0.0120967741935484 0.450943548387097 0.99244353837723 0.999588144403624 GO:0140098 catalytic activity, acting on RNA 4/500 387/18639 0.0103359173126615 0.385302325581395 0.993172779211505 0.999588144403624 GO:0004842 ubiquitin-protein transferase activity 5/500 449/18639 0.0111358574610245 0.415122494432071 0.993644314603815 0.999588144403624 GO:0030371 translation repressor activity 3/500 329/18639 0.00911854103343465 0.339920972644377 0.993672434397794 0.999588144403624 GO:0015276 ligand-gated monoatomic ion channel activity 1/500 186/18639 0.00537634408602151 0.20041935483871 0.993800579840321 0.999588144403624 GO:0022834 ligand-gated channel activity 1/500 188/18639 0.00531914893617021 0.198287234042553 0.994131994475842 0.999588144403624 GO:0140597 protein carrier chaperone 1/500 188/18639 0.00531914893617021 0.198287234042553 0.994131994475842 0.999588144403624 GO:0008168 methyltransferase activity 1/500 204/18639 0.00490196078431373 0.182735294117647 0.996219827615325 0.999588144403624 GO:0061630 ubiquitin protein ligase activity 3/500 353/18639 0.0084985835694051 0.316810198300283 0.996297919481591 0.999588144403624 GO:0016887 ATP hydrolysis activity 4/500 417/18639 0.00959232613908873 0.35758273381295 0.996349843077316 0.999588144403624 GO:0008094 ATP-dependent activity, acting on DNA 1/500 210/18639 0.00476190476190476 0.177514285714286 0.996794829136912 0.999588144403624 GO:0061659 ubiquitin-like protein ligase activity 3/500 372/18639 0.00806451612903226 0.300629032258065 0.997592451758304 0.999588144403624 GO:0046873 metal ion transmembrane transporter activity 4/500 450/18639 0.00888888888888889 0.33136 0.998196280878454 0.999588144403624 GO:0022836 gated channel activity 2/500 318/18639 0.00628930817610063 0.234452830188679 0.998383845748431 0.999588144403624 GO:0005261 monoatomic cation channel activity 2/500 341/18639 0.00586510263929619 0.218639296187683 0.999088422595147 0.999588144403624 GO:0005216 monoatomic ion channel activity 3/500 448/18639 0.00669642857142857 0.249629464285714 0.999588144403624 0.999588144403624