category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	126/1440	250/9376	3.2816	CTSD/PSAP/LAPTM5/CTSB/CTSS/CD68/CTSZ/NPC2/ASAH1/ACP5/LIPA/LGMN/CTSH/VAMP8/HEXB/CTSA/ATP6V0D1/ATP6V0E1/ATP6V0B/TPP1/SLC11A1/ATP6V1F/AP1S2/PPT1/SLC15A3/GNS/ATP6V1G1/SLC17A5/IDS/ATP6V1B2/CTSL/AP2S1/LAMP2/HEXA/RRAGD/SCARB2/LAMTOR4/CTSC/MITF/FUCA1/ATP6AP1/DMXL2/LAMP1/VPS13C/ARL8A/ATP6V1A/ACP2/MANBA/GUSB/M6PR/ATP6V0A1/NAGLU/IGF2R/LAPTM4A/PLA2G15/GNPTG/DNASE2/BLOC1S2/CLCN7/GGA1/AP1B1/GAA/LITAF/BLOC1S6/RRAGC/GLA/ATP6V1C1/MCOLN1/TFEB/GLB1/CLN8/GALNS/BLOC1S1/AP3S1/RAB7A/SLC29A3/CTSO/TCIRG1/TPCN1/GNPTAB/TLR7/ARSA/GPR155/NAGPA/CTBS/ARL8B/ATP6V1H/NPC1/AP2B1/TLR8/SUMF1/HGSNAT/NEU1/GALC/GGA2/VPS41/AGA/SLC11A2/SMPD1/LAMTOR3/SLC2A6/SGSH/ENTPD4/OSTM1/VPS39/CTSF/TFE3/AP2A2/NAGA/OSBPL1A/ZFYVE26/SNAPIN/AP1G1/ARSB/SPG11/CTSK/DNASE2B/ARSG/CLTC/SLC15A4/TMEM175/ATP6V0D2/VAMP7/DTNBP1/MAN2B1/PLEKHM1	15.5752610699291
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	86/1440	181/9376	3.09367710251688	HLA-DRA/CD74/CTSD/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/FCER1G/HLA-DMA/HLA-DQB1/ITGB2/HLA-DQA1/FCGR3A/HLA-DMB/LSP1/IL18/ATP6V0D1/ATP6V0B/HLA-DQA2/IL1B/HLA-DRB5/FCGR1A/ITGAX/CORO1A/IFNGR2/CD14/BID/FCGR2A/LAMP2/SYK/CLEC7A/C3/STAT1/ITGAM/ATP6AP1/PLK3/LAMP1/CEBPB/MRC2/HLA-DOA/TLR4/TNF/ATP6V0A1/TLR2/CAMK2D/IL10/IFNGR1/CIITA/IRAK1/RAB7A/NFKB1/TGFB2/TLR1/RAB5C/TCIRG1/TRADD/TNFRSF1A/SPHK1/IL10RA/JAK2/RAB5B/ATP6V1H/MAPK1/MAPK8/CARD9/VDR/CAMK2G/MYD88/RAB5A/IL1A/RIPK2/IL10RB/CLEC4E/EP300/RFX5/CREBBP/BCL2/FCGR2B/BAX/JAK1/TLR6/CAMP/PPP3CB/RELA/MAPK13/ATP6V0D2	12.1154396533793
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	70/1440	142/9376	3.20970266040689	TYROBP/TREM2/NFKBIA/JUNB/ACP5/JUN/FCGR3A/SPI1/NCF2/FOSB/JUND/CYBA/IL1B/SQSTM1/LILRB4/FCGR1A/FOS/IFNGR2/LCP2/SIRPA/FCGR2A/TGFBR1/OSCAR/SYK/MITF/STAT1/TGFBR2/BTK/SOCS3/TNF/LILRB1/LILRB3/IFNGR1/LILRB2/CSF1R/ITPR2/SOCS1/NFKB1/TGFB2/PIK3R1/BLNK/LILRA2/TNFRSF1A/NFKB2/CYLD/RELB/NCF4/SIRPB1/MAPK1/STAT2/MAPK8/ITPR1/CSF1/IKBKB/IL1A/TAB2/PLCG2/PIK3CA/MAP2K1/PIK3CD/LILRA6/FCGR2B/FOSL2/CTSK/JAK1/PPP3CB/TYK2/RELA/LILRA5/MAPK13	11.3018393653311
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	48/1440	78/9376	4.00683760683761	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/NFKBIA/HLA-DQB1/ITGB2/HLA-DQA1/JUN/FCGR3A/HLA-DMB/NCF2/CYBA/HLA-DQA2/IL1B/HLA-DRB5/FCGR1A/CYBB/FOS/IFNGR2/FCGR2A/C3/PTPN6/STAT1/ITGAM/HLA-DOA/PTGS2/TLR4/TNF/TLR2/IL10/IFNGR1/IRAK1/NFKB1/TGFB2/ITGA4/NCF4/JAK2/MAPK1/MYD88/IL1A/PRKCB/TAB2/JAK1/EEF1A1/RELA/MAPK13	11.3586981465135
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	52/1440	95/9376	3.56397660818713	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/ITGB2/HLA-DQA1/ACP5/JUN/CCL3/CXCL2/HLA-DMB/CXCL3/IL18/TNFSF13B/ATP6V0D1/ATP6V0E1/ATP6V0B/HLA-DQA2/IL1B/ATP6V1F/HLA-DRB5/CD86/ATP6V1G1/ICAM1/FOS/CCL20/ATP6V1B2/CTSL/ATP6AP1/VEGFA/HLA-DOA/ATP6V1A/TLR4/TNF/ATP6V0A1/TLR2/CCL5/FLT1/ATP6V1C1/TGFB2/TCIRG1/CCL2/ITGAL/ATP6V1H/CSF1/IL1A/LTB/CTSK/IL15/ATP6V0D2	10.6990330643792
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	70/1440	155/9376	2.94050179211469	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/OLR1/HLA-DMA/MSR1/HLA-DQB1/ITGB2/HLA-DQA1/FCGR3A/HLA-DMB/HLA-E/NCF2/CD36/CYBA/ATP6V0D1/ATP6V0E1/ATP6V0B/HLA-DQA2/HLA-F/TUBA1A/ATP6V1F/HLA-DRB5/FCGR1A/CYBB/CORO1A/ATP6V1G1/ATP6V1B2/CD14/CTSL/FCGR2A/HLA-C/LAMP2/TUBB2A/CLEC7A/C3/MARCO/ITGAM/ATP6AP1/SCARB1/LAMP1/MRC2/HLA-DOA/ATP6V1A/TLR4/M6PR/ATP6V0A1/TLR2/TFRC/STX7/ATP6V1C1/RILP/RAB7A/RAB5C/TCIRG1/STX12/NCF4/RAB5B/ATP6V1H/THBS3/RAB5A/TUBA4A/FCGR2B/TLR6/ITGB5/ATP6V0D2	10.3766445642393
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	57/1440	112/9376	3.31369047619048	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/NFKBIA/HSPA1A/HLA-DQB1/HLA-DQA1/HSPA1B/HLA-DMB/LY96/GNAI2/HLA-DQA2/HLA-DRB5/IFNGR2/ALOX5/BIRC3/STAT1/HLA-DOA/TLR4/TNF/CD40/HSPA6/TLR2/IL10/IFNGR1/PIK3R5/MAP2K3/SOCS1/CIITA/IRAK1/NFKB1/TGFB2/TNFRSF1A/BCL2L1/IL10RA/PDPK1/JAK2/STAT3/MAPK1/MAPK8/IKBKB/PPIF/MYD88/XIAP/IL10RB/BCL2/TAB2/CCR5/BIRC2/JAK1/TYK2/LAMB2/RELA/MAPK13/BIRC7	10.4925501038263
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	53/1440	109/9376	3.16595310907238	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/NFKBIA/HLA-DQB1/HLA-DQA1/JUN/HLA-DMB/HLA-DQA2/IL1B/EBI3/HLA-DRB5/CD4/IL6ST/FOS/IFNGR2/TGFBR1/AHR/STAT1/TGFBR2/HLA-DOA/IL2RG/IL6R/NFKBIE/STAT6/STAT5A/IFNGR1/RUNX1/NFKB1/HSP90AA1/IL4R/IL27RA/JAK2/SMAD3/STAT3/RARA/MAPK1/MAPK8/IL2RB/IKBKB/NFATC3/LAT/IL1RAP/HIF1A/RXRA/JAK1/PPP3CB/TYK2/IL12RB1/RELA/MAPK13	9.68854972249251
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	76/1440	196/9376	2.52471655328798	HLA-B/HLA-A/NFKBIA/ZFP36/JUN/CXCL2/HLA-E/CLEC2B/CXCL3/CDKN1A/HLA-F/CD86/ICAM1/IL6ST/FOS/BID/HLA-C/MAP1LC3B/SYK/C3/STAT1/VEGFA/HCK/PTGS2/PREX1/UBC/IFNGR1/PIK3R5/ITPR2/LYN/CDK6/KRAS/NFKB1/PIK3R1/TRADD/TNFRSF1A/PDGFB/JAK2/GNGT2/STAT3/MAPK1/STAT2/MAPK8/ITPR1/IKBKB/NFATC3/MAPKAPK2/MICA/CCR1/MICB/EP300/CREBBP/BECN1/UBB/PLCG2/RCAN1/PIK3CA/HIF1A/RB1/GNB4/MAP2K1/PIK3CD/BAX/CCR5/IRF7/FAS/JAK1/PPP3CB/TYK2/TICAM1/GNG7/TCF7L2/IKBKE/RELA/MAPK13/TCF7	9.18886487306222
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	81/1440	216/9376	2.44166666666667	OLR1/NFKBIA/HSPA1A/HSPA1B/JUN/CCL3/CXCL2/SOD2/LY96/NCF2/PYCARD/ABCA1/CD36/CXCL3/CYBA/IL18/IL1B/TNFSF10/CYBB/ICAM1/FOS/NFE2L2/CD14/BID/MMP9/CASP1/ABCG1/RAP1A/TLR4/TNF/POU2F2/CD40/HSPA6/TLR2/CAMK2D/CCL5/MAP2K3/PLCB2/LYN/VAV1/KRAS/IRAK1/NFKB1/PIK3R1/HSP90AA1/DDIT3/MAP3K5/CCL2/TNFRSF1A/NLRP3/BCL2L1/PDPK1/NCF4/JAK2/STAT3/MAPK1/MAPK8/VAV3/ERN1/ITPR1/IKBKB/CAMK2G/NFATC3/MYD88/BCL2/TAB2/PIK3CA/RXRA/RAP1B/TNFRSF10A/PIK3CD/BAX/IRF7/FAS/TLR6/PPP3CB/TICAM1/IKBKE/EIF2AK3/RELA/MAPK13	9.13082565719473
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	72/1440	187/9376	2.50695187165775	CTSB/NFKBIA/TXNIP/JUN/CXCL2/PYCARD/CXCL3/CYBA/IL18/IL1B/GPSM3/IFI16/CYBB/TNFAIP3/GABARAPL1/NAMPT/GABARAPL2/MAP1LC3B/BIRC3/CARD16/CASP1/GABARAP/STAT1/TLR4/TNF/OAS2/PKN1/TRPV2/CCL5/P2RX7/GBP4/ITPR2/PLCB2/PSTPIP1/GBP5/NFKB1/HSP90AA1/CCL2/GBP2/NLRP3/GBP3/BCL2L1/MAPK1/STAT2/MAPK8/CARD9/ITPR1/CARD6/NAIP/IKBKB/MYD88/XIAP/RIPK2/BCL2/TAB2/ANTXR2/OAS1/PRKCD/ANTXR1/IRF7/BIRC2/RIPK3/JAK1/CAMP/TYK2/TICAM1/CARD8/TRPM7/IKBKE/NLRX1/RELA/MAPK13	8.8664978769915
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	81/1440	224/9376	2.35446428571429	HLA-DRA/HLA-B/HLA-A/B2M/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/NFKBIA/HLA-DQB1/ITGB2/ZFP36/HLA-DQA1/JUN/HLA-DMB/HLA-E/SPI1/HLA-DQA2/CDKN1A/HLA-F/HLA-DRB5/TSPO/CD4/ICAM1/FOS/EGR1/HLA-C/TGFBR1/CREB5/ADCY7/TGFBR2/HLA-DOA/IL2RG/TNF/CD40/MMP7/STAT5A/PRKACB/NRP1/KRAS/NFKB1/TGFB2/ATM/PIK3R1/IL1R2/ITGAL/TNFRSF1A/NFKB2/VAC14/SLC25A5/BCL2L1/RELB/SMAD3/MAPK1/MAPK8/EGR2/IL2RB/ANAPC16/IKBKB/NFATC3/LTBR/XIAP/EP300/CREBBP/MAP3K3/PIK3CA/RB1/MAP2K1/PIK3CD/CCND2/BAX/ANAPC13/MAP3K1/JAK1/IL15/PPP3CB/PRKACA/ELK4/ATF6B/RELA/IL15RA	8.73976220296968
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	58/1440	138/9376	2.7365539452496	FN1/NFKBIA/JUN/PYCARD/IL18/IL1B/CD4/FOS/LCP2/FCGR2A/CASP1/RAC2/WAS/SKAP2/TLR4/TNF/GIT2/PKN1/RHOG/IL10/RPS6KA1/MAP2K3/GNAQ/VAV1/LIMK1/IRAK1/NFKB1/PIK3R1/BAIAP2/RPS6KA3/CCL2/ITGA4/NLRP3/MAPK1/MAPK8/VAV3/IKBKB/RPS6KA2/NFATC3/MYD88/WIPF2/WIPF1/LAT/ARHGEF7/WASF2/TAB2/PIK3CA/MAP2K1/ACTR2/PIK3CD/WIPF3/ARPC2/ARPC1B/TICAM1/ARPC4/RELA/MAPK13/PTK2B	8.75396685532796
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	67/1440	173/9376	2.52164418754014	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/NFKBIA/HLA-DQB1/HLA-DQA1/HLA-DMB/DNAJB1/PYCARD/IL18/HLA-DQA2/IL1B/TNFSF10/HLA-DRB5/ICAM1/IFNGR2/BID/CASP1/STAT1/HLA-DOA/SOCS3/TLR4/TNF/OAS2/MX2/CCL5/IFNGR1/CDK6/CIITA/NFKB1/PIK3R1/TRADD/CXCL10/TLR7/CCL2/TNFRSF1A/NLRP3/SLC25A5/JAK2/MAPK1/STAT2/IKBKB/MYD88/IFIH1/IL1A/EP300/CREBBP/PRKCB/RSAD2/HNRNPUL1/PIK3CA/OAS1/MAP2K1/TNFRSF10A/PIK3CD/BAX/IRF7/FAS/JAK1/TYK2/TICAM1/ADAR/IKBKE/NLRX1/RELA	8.60473513319925
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	75/1440	205/9376	2.38211382113821	HLA-DRA/HLA-B/VIM/HLA-A/B2M/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/NFKBIA/HLA-DQB1/HLA-DQA1/JUN/GADD45B/CD44/HLA-DMB/HLA-E/HLA-DQA2/CDKN1A/TAPBP/HLA-F/HLA-DRB5/TNFAIP3/ICAM1/BID/HLA-C/CD58/SYK/STAT1/BTK/HLA-DOA/ENTPD1/TNF/OAS2/GADD45G/CD40/NFKBIE/TAPBPL/TLR2/MAP2K3/HES1/LYN/CDK6/IRAK1/NFKB1/PIK3R1/TRADD/BLNK/CXCL10/ITGAL/NFKB2/RELB/RUNX3/STAT3/STAT2/MAPK8/IKBKB/MYD88/BCL2/USP7/TAB2/PLCG2/PIK3CA/OAS1/RB1/PIK3CD/CCND2/BAX/IRF7/FAS/JAK1/TYK2/IKBKE/RELA/MAPK13	8.52272446992149
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	85/1440	248/9376	2.23163082437276	NFKBIA/S100A10/JUN/LY96/PYCARD/PTPRC/IL18/IL1B/TUBA1A/RHOB/TNFSF10/FOS/CD14/NCKAP1L/TUBB2A/BIRC3/CASP1/AHNAK/ARL8A/DYNLT1/STX10/TLR4/TNF/M6PR/PKN1/RHOG/CYTH1/TLR2/PLEKHM2/MAP2K3/CYTH4/BRK1/ABI1/RILP/IRAK1/RAB7A/NFKB1/RAB5C/CYFIP1/HSP90AA1/TRADD/TNFRSF1A/TLR5/NLRP3/AHNAK2/ARL8B/RAB5B/MAPK1/MAPK8/NAIP/IKBKB/VPS41/MYD88/RAB5A/RIPK2/BCL2/TAB2/VPS39/PIK3CA/FLNA/TUBA4A/MLKL/MAP2K1/ACTR2/FHOD1/TNFRSF10A/PIK3CD/BAX/RAB9A/BIRC2/ARPC2/CYTH2/ARPC1B/RIPK3/TLR6/TCF7L2/ARPC4/KPNA3/RHOH/KLC1/KPNA4/RELA/MAPK13/TCF7/PLEKHM1	8.37306820652865
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	68/1440	180/9376	2.45975308641975	HLA-DRA/HLA-B/CD74/HLA-A/B2M/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/NFKBIA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-E/BST2/HLA-DQA2/IL1B/TAPBP/HLA-F/HLA-DRB5/PILRA/TNFRSF14/IFNGR2/BID/HLA-C/SYK/BIRC3/C3/STAT1/HLA-DOA/SOCS3/TNF/POU2F2/OAS2/TAPBPL/TLR2/CCL5/IFNGR1/IRAK1/NFKB1/PIK3R1/TRADD/CCL2/TNFRSF1A/BCL2L1/JAK2/STAT2/CARD9/RHEB/IKBKB/MYD88/IFIH1/TNFSF14/BCL2/TAB2/PIK3CA/SP100/OAS1/PIK3CD/BAX/IRF7/BIRC2/FAS/JAK1/TYK2/TICAM1/IKBKE/RELA	8.42329921486768
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	56/1440	137/9376	2.66147607461476	CTSD/CTSB/CTSS/CTSZ/NFKBIA/BCL2A1/JUN/GADD45B/CTSH/TUBA1A/TNFSF10/CSF2RB/FOS/CTSL/BID/CTSC/MCL1/BIRC3/CFLAR/TNF/GADD45G/ITPR2/KRAS/NFKB1/ATM/PIK3R1/DDIT3/CTSO/TRADD/MAP3K5/TNFRSF1A/BCL2L1/PDPK1/MAPK1/MAPK8/PARP4/ENDOG/ERN1/PMAIP1/ITPR1/IKBKB/XIAP/BCL2/PIK3CA/CTSF/TUBA4A/MAP2K1/TNFRSF10A/PIK3CD/BAX/BIRC2/BBC3/FAS/CTSK/EIF2AK3/RELA	8.34464655521838
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	51/1440	119/9376	2.79047619047619	NFKBIA/JUNB/JUN/CXCL2/CXCL3/IL1B/TNFAIP3/ICAM1/FOS/CCL20/CREB5/MMP9/BIRC3/CFLAR/TNFRSF1B/CEBPB/IRF1/PTGS2/SOCS3/TNF/BCL3/CCL5/MAP2K3/NFKB1/PIK3R1/MAP3K8/TRADD/MAP3K5/CXCL10/CCL2/TNFRSF1A/CYLD/RHBDF2/MAPK1/MAPK8/CSF1/IKBKB/ADAM17/XIAP/TAB2/PIK3CA/MLKL/MAP2K1/PIK3CD/BIRC2/FAS/RIPK3/IL15/ATF6B/RELA/MAPK13	8.37284311400889
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	47/1440	105/9376	2.91449735449735	NFKBIA/BCL2A1/GADD45B/CXCL2/LY96/CXCL3/TNFSF13B/IL1B/TNFAIP3/ICAM1/CCL4/CD14/SYK/BIRC3/CFLAR/BTK/PTGS2/TLR4/TNF/PLAU/GADD45G/CD40/LYN/IRAK1/NFKB1/ATM/TRADD/BLNK/TNFRSF1A/NFKB2/BCL2L1/CYLD/RELB/IKBKB/MYD88/LTBR/LAT/TNFSF14/XIAP/BCL2/PRKCB/TAB2/PLCG2/LTB/BIRC2/TICAM1/RELA	8.40334481292872
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	43/1440	93/9376	3.010513739546	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/NFKBIA/HLA-DQB1/HLA-DQA1/JUN/HLA-DMB/HLA-DQA2/HLA-DRB5/CD4/FOS/IFNGR2/NOTCH2/STAT1/HLA-DOA/IL2RG/MAF/NFKBIE/STAT6/STAT5A/IFNGR1/NFKB1/IL4R/JAK2/RUNX3/MAPK1/MAPK8/IL2RB/IKBKB/NFATC3/LAT/STAT4/JAK1/PPP3CB/TYK2/IL12RB1/NOTCH1/MAML2/RELA/MAPK13	8.29985297114296
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	42/1440	91/9376	3.00512820512821	NFKBIA/CD81/JUN/LILRB4/FOS/SYK/PTPN6/RAC2/PIK3AP1/CD72/BTK/RASGRP3/DAPP1/LILRB1/NFKBIE/LILRB3/LILRB2/LYN/VAV1/KRAS/NFKB1/PIK3R1/BLNK/LILRA2/CD22/INPPL1/MAPK1/VAV3/INPP5D/SOS1/IKBKB/NFATC3/PRKCB/PLCG2/PIK3CA/MAP2K1/PIK3CD/LILRA6/FCGR2B/PPP3CB/RELA/LILRA5	8.18724794389173
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	47/1440	109/9376	2.80754332313965	SPP1/NFKBIA/JUN/CCL3/LY96/IL1B/CD86/CCL4/FOS/CD14/STAT1/TLR4/TNF/CD40/TLR2/CCL5/MAP2K3/IRF5/IRAK1/NFKB1/TLR1/PIK3R1/MAP3K8/CXCL10/TLR7/TLR5/CXCL9/MAPK1/STAT2/MAPK8/TLR8/IKBKB/MYD88/TAB2/PIK3CA/MAP2K1/PIK3CD/IRF7/CTSK/JAK1/TLR6/TYK2/TICAM1/TOLLIP/IKBKE/RELA/MAPK13	8.0853427936388
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	93/1440	300/9376	2.01844444444444	DUSP1/HSPA1A/HSPA1B/JUN/GADD45B/DUSP2/JUND/HSPB1/IL1B/IGF2/ARRB2/MAP3K2/EREG/FOS/CD14/TGFBR1/MRAS/RAC2/TGFBR2/VEGFA/MAPKAPK3/DUSP10/RASGRP3/RAP1A/NR4A1/RASGRF2/TNF/MEF2C/GADD45G/HSPA6/AREG/HGF/RPS6KA1/PRKACB/DUSP3/CSF1R/FLT1/MAP2K3/TAOK1/VEGFB/RAPGEF2/KRAS/IRAK1/NFKB1/TGFB2/DDIT3/MAP3K8/TRADD/MAP3K5/RPS6KA3/ARRB1/TNFRSF1A/NFKB2/PDGFB/RELB/MAPK1/MAPK8/PTPN7/MAX/SOS1/GNA12/MAP3K11/RASA1/CACNA2D4/CSF1/DUSP6/IKBKB/RPS6KA2/NFATC3/MAPKAPK2/MYD88/PLA2G4C/IL1A/IL1RAP/LAMTOR3/PRKCB/TAB2/MAP3K3/FLNA/STK4/RAP1B/MAP2K1/MAPK8IP2/TAOK3/MAP3K1/FAS/PPP3CB/PRKACA/PDGFC/ELK4/RELA/MAPK13/MAPK8IP3	7.63689433859493
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	34/1440	66/9376	3.35420875420875	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/JUN/HLA-DMB/IL18/HLA-DQA2/IL1B/HLA-DRB5/IFNGR2/STAT1/HLA-DOA/IL2RG/TLR4/TNF/MAF/STAT6/TLR2/IL10/IFNGR1/NFKB1/TGFB2/IL4R/TLR5/SMAD3/STAT3/IL1A/STAT4/IL12RB1/RELA	8.17538384042507
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	59/1440	163/9376	2.35678254942059	NFKBIA/JUN/CDKN1A/HSPG2/FOS/BID/TGFBR1/CREB5/MMP9/STAT1/TGFBR2/ATP6AP1/TLR4/TNF/STAT6/TLR2/STAT5A/MAP2K3/KRAS/IRAK1/NFKB1/TGFB2/PIK3R1/JAK2/SMAD3/STAT3/MAPK1/STAT2/MAPK8/EGR2/SOS1/IKBKB/NFATC3/MYD88/IFIH1/EP300/CREBBP/BCL2/PRKCB/TAB2/PIK3CA/RB1/MAP2K1/PIK3CD/BAX/IRF7/DDB1/STAT4/MAP3K1/FAS/JAK1/EGR3/TYK2/TICAM1/IKBKE/ATF6B/RELA/MAPK13/PTK2B	7.44336936130358
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	44/1440	105/9376	2.72846560846561	FCER1G/NFKBIA/JUN/LSP1/PYCARD/IL1B/SYK/CLEC7A/CASP1/MRAS/STAT1/PLK3/IRF1/PTGS2/TNF/BCL3/IL10/ITPR2/KRAS/NFKB1/PIK3R1/NFKB2/NLRP3/CYLD/RELB/MAPK1/STAT2/MAPK8/CARD9/EGR2/ITPR1/IKBKB/NFATC3/MAPKAPK2/CLEC4E/PLCG2/PIK3CA/PRKCD/PIK3CD/EGR3/PPP3CB/IKBKE/RELA/MAPK13	7.58679163024418
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	67/1440	201/9376	2.17037037037037	HPGD/BCL2A1/GADD45B/ID2/SPI1/CDKN1A/NFKBIZ/NUPR1/FCGR1A/CD86/NR4A3/CD14/REL/MMP9/MITF/BIRC3/TGFBR2/ITGAM/CEBPB/BCL6/LYL1/LMO2/MEF2C/PLAU/GADD45G/CD40/PBX3/MAF/ETV6/CEBPA/BMP2K/CSF1R/FLT1/JMJD1C/ASPSCR1/RUNX1/NFKB1/ATM/IL1R2/DDIT3/FOXO1/FLI1/BCL2L1/RARA/PTCRA/MAX/IL2RB/DUSP6/CDK14/HHEX/ARNT2/KMT2A/KLF3/DDX5/RXRA/TFE3/ITGB7/CCND2/BAX/RUNX2/BIRC2/IGFBP3/AFF1/ELK4/RELA/BMI1/CEBPE	7.14470604643434
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	42/1440	103/9376	2.65501618122977	NFKBIA/JUN/CCL3/SERPINE1/GNAI2/C1QB/C1QA/IL1B/C1QC/FOS/IFNGR2/TGFBR1/C3/TGFBR2/CFLAR/TLR4/TNF/TLR2/CCL5/IL10/IFNGR1/GNA15/GNAQ/PLCB2/IRAK1/NFKB1/TGFB2/PIK3R1/CCL2/TNFRSF1A/MAPK1/MAPK8/IKBKB/MYD88/PPP2CB/PIK3CA/PIK3CD/FAS/TLR6/TICAM1/RELA/MAPK13	7.19410515275139
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	58/1440	169/9376	2.23458251150559	CTSD/CTSB/VAMP8/SQSTM1/GABARAPL1/GABARAPL2/CTSL/LAMP2/MAP1LC3B/RRAGD/MRAS/GABARAP/CFLAR/LAMP1/IRS2/DAPK1/UBC/PRKACB/STX7/RRAGC/C9orf72/KRAS/RAB7A/PIK3R1/BCL2L1/ATG7/PDPK1/NBR1/MAPK1/MAPK8/OPTN/RB1CC1/RHEB/ATG16L2/ERN1/ITPR1/VPS41/UVRAG/TP53INP2/RAB1A/MTMR14/BCL2/BECN1/UBB/PPP2CB/VPS39/PIK3CA/EPG5/HIF1A/PRKCD/MAP2K1/PIK3CD/MTMR3/DDIT4/PRKACA/EIF2AK3/BIRC6/PLEKHM1	6.89875077840787
Human Diseases	Infectious disease: viral	hsa05162	Measles	50/1440	136/9376	2.3937908496732	NFKBIA/HSPA1A/HSPA1B/JUN/IL1B/TNFAIP3/MSN/FOS/BID/STAT1/IL2RG/TLR4/OAS2/CD46/MX2/HSPA6/TLR2/STAT5A/CDK6/IRAK1/NFKB1/PIK3R1/TRADD/TLR7/BCL2L1/STAT3/STAT2/MAPK8/IL2RB/IKBKB/MYD88/IFIH1/IL1A/BCL2/TAB2/PIK3CA/OAS1/PIK3CD/CCND2/FCGR2B/BAX/IRF7/RAB9A/BBC3/FAS/JAK1/TYK2/ADAR/IKBKE/RELA	6.97424391641466
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	40/1440	100/9376	2.60444444444444	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/CD9/CD44/CD37/HLA-DMB/CD36/HLA-DQA2/IL1B/HLA-DRB5/FCGR1A/CD4/CD14/ITGAM/HLA-DOA/TNF/CSF2RA/ANPEP/IL6R/CD33/CD59/IL7R/TFRC/CSF1R/CSF3R/IL1R2/IL4R/ITGA4/CD22/CSF1/CD1D/CD38/ITGA3/IL1A/ITGA1	6.87084843502359
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	64/1440	200/9376	2.08355555555556	NFKBIA/JUN/PYCARD/IL18/IL1B/TUBA1A/TNFSF10/FOS/FCGR2A/NCKAP1L/TUBB2A/CASP1/PTPN6/GNA13/MYO1F/TLR4/TNF/MYO5A/CYTH1/CYTH4/BRK1/ABI1/IRAK1/NFKB1/CYFIP1/TRADD/BAIAP2/CLDN19/TJP1/TNFRSF1A/TLR5/NLRP3/MAPK1/MAPK8/MYO1G/GNA12/SEC24D/NAIP/HCLS1/ARHGEF2/IKBKB/MYD88/WIPF2/WIPF1/WASF2/RAB1A/TAB2/TUBA4A/ACTR2/TNFRSF10A/BAX/WIPF3/LPAR2/ARPC2/SEC24A/ARHGEF11/CYTH2/ARPC1B/FAS/CLDN23/MYO1C/ARPC4/RELA/MAPK13	6.59789702666045
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	70/1440	227/9376	2.00783162016642	HLA-B/HLA-A/B2M/NFKBIA/CCL3/HLA-E/CXCR4/GNAI2/CDKN1A/IL1B/TAPBP/HLA-F/CCL4/BID/HLA-C/CREB5/PTGER4/GNA13/RAC2/ADCY7/VEGFA/AKAP13/PTGS2/TNF/IL6R/TAPBPL/CCL5/PRKACB/ITPR2/GNAQ/PLCB2/CDK6/KRAS/NFKB1/PIK3R1/TRADD/CCL2/TNFRSF1A/PTGER3/IL10RA/GNGT2/STAT3/MAPK1/RHEB/SOS1/ITPR1/GNA12/IKBKB/NFATC3/CCR1/IL10RB/PRKCB/PIK3CA/RB1/GNB4/PTGER2/MAP2K1/PIK3CD/BAX/CCR5/ARHGEF11/FAS/JAK1/PPP3CB/PRKACA/GNG7/ATF6B/RELA/MAPK13/PTK2B	6.5475699894389
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	62/1440	193/9376	2.09165227403569	NFKBIA/CCL3/CXCL2/CXCR4/CXCL16/CXCL3/GNAI2/ARRB2/CCL4/CCL20/CCL18/FGR/RAC2/DOCK2/STAT1/ADCY7/WAS/HCK/RAP1A/PREX1/FOXO3/CCL5/CCL7/PRKACB/PIK3R5/GNAQ/PLCB2/LYN/VAV1/KRAS/NFKB1/PIK3R1/TIAM1/GRK4/CXCL10/ARRB1/CCL2/JAK2/GNGT2/STAT3/CXCL9/MAPK1/STAT2/VAV3/SOS1/IKBKB/XCR1/CCR1/PRKCB/PLCG2/PIK3CA/CCL23/RAP1B/PRKCD/GNB4/MAP2K1/PIK3CD/CCR5/PRKACA/GNG7/RELA/PTK2B	6.52734760109856
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	66/1440	214/9376	2.00809968847352	HLA-B/HLA-A/B2M/NFKBIA/JUN/HLA-E/CXCR4/SAMHD1/BST2/GNAI2/TAPBP/HLA-F/AP1S2/CD4/FOS/BID/HLA-C/RAC2/TNFRSF1B/TLR4/TNF/APOBEC3C/TAPBPL/TLR2/AP1B1/ITPR2/MAP2K3/GNAQ/KRAS/LIMK1/IRAK1/NFKB1/ATM/PIK3R1/TRADD/TNFRSF1A/BCL2L1/GNGT2/APOBEC3G/MAPK1/MAPK8/ITPR1/IKBKB/NFATC3/MYD88/APOBEC3A/FBXW11/BCL2/PRKCB/TAB2/PLCG2/PIK3CA/GNB4/MAP2K1/PIK3CD/BAX/CCR5/AP1G1/DDB1/FAS/PPP3CB/GNG7/CUL5/RELA/MAPK13/PTK2B	6.35449845092489
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	47/1440	133/9376	2.30091896407686	GADD45B/SOD2/SGK1/CDKN1A/TNFSF10/HOMER3/GABARAPL1/GABARAPL2/PRKAG2/TGFBR1/KLF2/GABARAP/TGFBR2/PLK3/BCL6/IRS2/SGK3/CAT/GADD45G/FOXO3/IL7R/IL10/FBXO32/KRAS/TGFB2/ATM/PIK3R1/FOXO1/PDPK1/SMAD3/STAT3/MAPK1/MAPK8/S1PR4/SOS1/IKBKB/RBL2/PCK2/EP300/CREBBP/USP7/PIK3CA/STK4/MAP2K1/PIK3CD/CCND2/MAPK13	6.43629058390603
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	31/1440	71/9376	2.84287949921753	NFKBIA/JUN/CXCL2/CXCL3/ATP6V0D1/ATP6V0E1/ATP6V0B/ATP6V1F/HBEGF/ATP6V1G1/ATP6V1B2/ATP6AP1/ATP6V1A/ATP6V0A1/JAM2/CCL5/ATP6V1C1/LYN/CSK/NFKB1/TCIRG1/TJP1/ATP6V1H/MAPK8/ADAM10/IKBKB/ADAM17/PLCG2/RELA/MAPK13/ATP6V0D2	6.63947865638747
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	73/1440	250/9376	1.90124444444444	HLA-B/HLA-A/HSPA1A/HSPA1B/HLA-E/CXCR4/HLA-F/ARRB2/RAB31/CHMP1B/DAB2/HLA-C/TGFBR1/AP2S1/TGFBR2/IL2RG/AGAP3/ARAP1/RAB11FIP1/GIT2/HSPA6/IGF2R/CYTH1/ARFGAP3/TFRC/SH3KBP1/SMAP2/CYTH4/CBL/SMURF2/SPG21/RAB7A/RAB5C/SNX1/GRK4/ARRB1/EHD1/ASAP3/SMAD3/RAB5B/RUFY1/AP2B1/RAB22A/IL2RB/IST1/CHMP3/WWP1/ARAP2/PLD1/WIPF2/EHD4/RAB5A/WIPF1/CAPZA2/VPS37B/ZFYVE16/AP2A2/ACTR2/PDCD6IP/CCR5/WIPF3/SH3GLB2/SNX3/ARPC2/FOLR3/IQSEC1/CYTH2/ARPC1B/RNF41/FOLR2/VPS28/CLTC/ARPC4	6.15231307417841
Human Diseases	Immune disease	hsa05330	Allograft rejection	21/1440	39/9376	3.50598290598291	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-E/HLA-DQA2/HLA-F/HLA-DRB5/CD86/HLA-C/HLA-DOA/TNF/CD40/IL10/FAS	6.67994340534936
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	26/1440	56/9376	3.02301587301587	NFKBIA/HSPA1A/ITGB2/HSPA1B/CXCL2/PYCARD/CXCL3/IL18/IL1B/CD14/C3/CASP1/ITGAM/TLR4/TNF/HSPA6/TLR2/CLK1/NFKB1/TLR5/NFKB2/NAIP/MYD88/RAB1A/EEF1A1/RELA	6.46772286161614
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	33/1440	82/9376	2.62032520325203	HLA-DRA/HLA-B/CD74/HLA-A/B2M/HLA-DPA1/CTSB/HLA-DRB1/HLA-DPB1/CTSS/HLA-DMA/HSPA1A/HLA-DQB1/HLA-DQA1/HSPA1B/LGMN/HLA-DMB/HLA-E/HLA-DQA2/TAPBP/HLA-F/HLA-DRB5/CD4/IFI30/CTSL/HLA-C/HLA-DOA/TNF/HSPA6/TAPBPL/CIITA/HSP90AA1/RFX5	6.2773137231514
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	51/1440	157/9376	2.11507430997877	LIPA/DUSP2/SGK1/ABCA1/CD36/C1QB/C1QA/HAVCR2/C1QC/SIRPA/LRP1/PTGER4/ALOX5/CASP1/PTPN6/NR1H3/CEBPB/MERTK/CPT1A/PTGS2/AXL/PLA2G15/CAMK2D/IL10/RAB7A/RAB5C/SPHK1/TMEM30A/SIRPB1/JAK2/RAB5B/MAPK1/ADAM10/CAMK2G/NFATC3/VPS41/GPR132/MAPKAPK2/RAB5A/ADAM17/GULP1/SIGLEC10/VPS39/STAB1/HIF1A/RXRA/PTGER2/MAP2K1/ITGB5/CD47/MAPK13	6.00174837677163
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	41/1440	115/9376	2.32135265700483	NR4A2/MAFB/SGK1/JUND/GNAI2/CDKN1A/HBEGF/ARRB2/FOS/EGR1/CREB5/GNA13/MEF2A/ADCY7/AKAP13/MEF2C/WNK1/PRKACB/ITPR2/GNAQ/PLCB2/ARRB1/MEF2D/MAPK1/PDE4B/VDR/ITPR1/GNA12/PDE4A/PLD1/STK39/BCL2/PRKCB/RXRA/MAP2K1/RUNX2/ARHGEF11/WNK2/PRKACA/ATF6B/PDE4C	6.07302089096587
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	22/1440	44/9376	3.25555555555556	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-E/HLA-DQA2/IL1B/HLA-F/HLA-DRB5/CD86/HLA-C/HLA-DOA/TNF/IL1A/FAS/ICA1	6.38790658237433
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	37/1440	101/9376	2.38525852585258	FN1/JUN/SERPINE1/IL1B/CYBB/ICAM1/EGR1/TGFBR1/STAT1/TGFBR2/VEGFA/TNF/STAT5A/PLCD3/PLCB2/VEGFB/KRAS/NFKB1/TGFB2/PIK3R1/FOXO1/CCL2/JAK2/SMAD3/STAT3/MAPK1/MAPK8/IL1A/BCL2/PRKCB/PLCG2/PIK3CA/PRKCD/PIK3CD/BAX/RELA/MAPK13	5.96211864578282
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	31/1440	78/9376	2.58774928774929	ITGB2/JUN/LY96/PYCARD/GNAI2/C1QB/C1QA/IL1B/C1QC/SERPING1/FOS/CD14/IRF8/C3/CASP1/C2/ITGAM/IRF1/TLR4/TNF/IL10/IRAK1/NFKB1/NLRP3/MAPK1/MAPK8/MYD88/IL1A/TICAM1/RELA/MAPK13	5.99791782930829
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	42/1440	125/9376	2.18773333333333	CTSD/FCER1G/ASAH1/GNAI2/BID/GNA13/RAC2/TNF/CERS6/SGMS2/GNAQ/PLCB2/KRAS/NFKB1/PIK3R1/TRADD/MAP3K5/TNFRSF1A/SPHK1/PDPK1/MAPK1/MAPK8/S1PR4/GNA12/PLD1/SMPD1/BCL2/PRKCB/PPP2CB/PIK3CA/MAP2K1/ADORA3/PIK3CD/SGMS1/BAX/SGPL1/NSMAF/SGPP1/DEGS1/PPP2R5E/RELA/MAPK13	5.69436977743106
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	49/1440	157/9376	2.03213021939137	HLA-B/HLA-A/GADD45B/SERPINE1/HLA-E/ZFP36L2/ZFP36L1/CDKN1A/SQSTM1/HLA-F/HLA-C/TGFBR1/MRAS/TGFBR2/HIPK2/GADD45G/HIPK3/FOXO3/ITPR2/MAP2K3/CDK6/KRAS/NFKB1/TGFB2/ATM/PIK3R1/RASSF5/FOXO1/SLC25A5/SMAD3/MAPK1/RHEB/ITPR1/NFATC3/RBL2/MAPKAPK2/IL1A/FBXW11/PIK3CA/RB1/MAP2K1/HIPK1/PIK3CD/CCND2/IGFBP3/PPP3CB/TRPM7/RELA/MAPK13	5.55531215580335
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	35/1440	98/9376	2.32539682539683	MARCKS/FCGR3A/PTPRC/GSN/FCGR1A/FCGR2A/SYK/RAC2/WAS/HCK/LYN/VAV1/LIMK1/PIK3R1/SPHK1/ASAP3/INPPL1/MAPK1/VAV3/INPP5D/PLD1/LAT/WASF2/PLA2G4C/PRKCB/PLCG2/PIK3CA/PRKCD/MAP2K1/ACTR2/PIK3CD/FCGR2B/ARPC2/ARPC1B/ARPC4	5.61820826696659
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	33/1440	90/9376	2.38740740740741	NFKBIA/JUN/CD4/FOS/IFNGR2/PTPN6/STAT1/TLR4/NFKBIE/TLR2/IFNGR1/MAP2K3/KRAS/NFKB1/PIK3R1/BATF/JAK2/STAT3/MAPK1/IKBKB/NFATC3/MYD88/LAT/MAP3K3/PIK3CA/HIF1A/MAP2K1/PIK3CD/JAK1/PPP3CB/TICAM1/RELA/MAPK13	5.63348287692787
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	51/1440	168/9376	1.9765873015873	FTL/FTH1/GLUL/PYCARD/IL1B/SQSTM1/TNFSF10/CYBB/TNFAIP3/CHMP1B/IFNGR2/BID/BIRC3/CASP1/STAT1/CFLAR/TLR4/TNF/STAT6/CAMK2D/STAT5A/IFNGR1/HSP90AA1/TRADD/TNFRSF1A/NLRP3/SLC25A5/CYLD/JAK2/STAT3/STAT2/MAPK8/CAMK2G/CHMP3/PLA2G4C/XIAP/IL1A/SMPD1/BCL2/MLKL/TNFRSF10A/BAX/BIRC2/PYGB/STAT4/FAS/RIPK3/JAK1/TYK2/TICAM1/TRPM7	5.440629013191
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	51/1440	168/9376	1.9765873015873	CSH1/CDKN1A/CSF2RB/CSH2/IL6ST/IFNGR2/OSM/MCL1/PTPN6/STAT1/IL2RG/SOCS3/CSF2RA/IL6R/STAT6/IL7R/STAT5A/IL10/IFNGR1/IL13RA1/SOCS1/CSF3R/PIK3R1/PIAS1/IL4R/BCL2L1/IL10RA/IL27RA/PDGFB/JAK2/STAT3/STAT2/SOS1/IL2RB/IL10RB/EP300/CREBBP/BCL2/PIK3CA/PIK3CD/CCND2/STAT4/JAK1/IL15/FHL1/OSMR/TYK2/PRLR/IL12RB1/SOCS6/IL15RA	5.440629013191
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	21/1440	45/9376	3.03851851851852	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-E/HLA-DQA2/IL1B/HLA-F/HLA-DRB5/CD86/HLA-C/HLA-DOA/TNF/IL1A/FAS	5.83879030080718
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	40/1440	120/9376	2.17037037037037	NFKBIA/JUN/ARHGDIB/SH2B3/RAP1A/MATK/NFKBIE/FOXO3/CAMK2D/RPS6KA1/KRAS/IRAK1/NFKB1/PIK3R1/MAP3K5/RPS6KA3/KIDINS220/PDPK1/MAPK1/MAPK8/SOS1/IRAK3/IKBKB/CAMK2G/RPS6KA2/MAPKAPK2/RIPK2/BCL2/MAP3K3/PLCG2/PIK3CA/RAP1B/PRKCD/MAP2K1/PIK3CD/PSEN2/BAX/MAP3K1/RELA/MAPK13	5.49627334400781
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	35/1440	100/9376	2.27888888888889	CCL3/CXCL2/CXCR4/CXCL3/IL18/TNFSF10/TNFRSF14/CCL4/IL6ST/CCL20/CCL18/TNFRSF1B/IL2RG/TNF/IL6R/CCL5/IL10/CCL7/CSF1R/CXCL10/CCL2/TNFRSF1A/IL10RA/CXCL9/IL2RB/CSF1/XCR1/CCR1/LTBR/TNFSF14/ACKR3/IL10RB/CCL23/TNFRSF10A/CCR5	5.47669428581174
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	29/1440	76/9376	2.48450292397661	OLR1/FABP5/CD36/CYP27A1/LPL/ACSL1/NR1H3/FABP3/GK/SLC27A1/PLIN2/CPT1A/FABP4/ACSL3/UBC/ACSL5/ANGPTL4/SCP2/PDPK1/PLTP/PCK2/FABP7/ME1/ACADM/ME3/RXRA/ACOX1/ACSL6/DBI	5.53493383790915
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	29/1440	77/9376	2.45223665223665	GADD45B/CDKN1A/TGFBR1/RAC2/STAT1/TGFBR2/VEGFA/GADD45G/RALGDS/CDK6/KRAS/NFKB1/TGFB2/PIK3R1/BCL2L1/ARHGEF6/SMAD3/STAT3/MAPK1/MAPK8/IKBKB/PLD1/PIK3CA/RB1/MAP2K1/PIK3CD/BAX/JAK1/RELA	5.45042900268389
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	42/1440	133/9376	2.05614035087719	HLA-B/TYROBP/HLA-A/FCER1G/ITGB2/FCGR3A/HLA-E/CD48/HCST/TNFSF10/ICAM1/IFNGR2/LCP2/BID/HLA-C/SYK/PTPN6/RAC2/SH3BP2/LAT2/TNF/IFNGR1/VAV1/KRAS/ICAM2/PIK3R1/ITGAL/MAPK1/VAV3/SOS1/MICA/LAT/MICB/PRKCB/PLCG2/PIK3CA/MAP2K1/TNFRSF10A/PIK3CD/FAS/PPP3CB/PTK2B	5.22524952233111
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	34/1440	99/9376	2.2361391694725	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/ITGB2/HLA-DQA1/FCGR3A/HLA-DMB/C5AR1/C1QB/C1QA/HLA-DQA2/FPR3/HLA-DRB5/FCGR1A/C1QC/CFD/ICAM1/C3AR1/FCGR2A/C3/C2/ITGAM/FPR1/PTAFR/HLA-DOA/IL10/SELPLG/ITGAL/KRT14/FCGR2B/CAMP	5.26680503148259
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	83/1440	333/9376	1.62288955622289	HLA-B/HLA-A/SPP1/FN1/HLA-E/ATP6V0D1/ATP6V0E1/ATP6V0B/CDKN1A/HLA-F/ATP6V1F/ATP6V1G1/ATP6V1B2/HLA-C/CREB5/NOTCH2/PTGER4/STAT1/ATP6AP1/VEGFA/IRF1/ATP6V1A/PTGS2/TNF/MX2/ATP6V0A1/HES2/PRKACB/LFNG/HES1/ATP6V1C1/UBR4/CDK6/KRAS/NFKB1/ATM/MFNG/PIK3R1/FOXO1/TCIRG1/TRADD/ITGA4/TNFRSF1A/ATP6V1H/MAPK1/STAT2/OASL/THBS3/RHEB/SOS1/IKBKB/LLGL2/RBL2/ITGA3/RFNG/APC/EP300/CREBBP/PPP2CB/PIK3CA/ITGA1/RB1/MAP2K1/ITGB7/PIK3CD/CCND2/BAX/FAS/JAK1/TYK2/TICAM1/ITGB5/PRKACA/TCF7L2/IKBKE/WNT2B/NOTCH1/MAML2/LAMB2/PPP2R5E/RELA/ATP6V0D2/TCF7	4.92995500185889
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	67/1440	253/9376	1.72428634167765	NFKBIA/JUN/CD44/PYCARD/IL18/IL1B/SQSTM1/CD14/MAP1LC3B/RRAGD/C3/CASP1/TLR4/TNF/CYTH1/FOXO3/UBC/CCL5/HK3/UBE2D1/CAST/PLCD3/ITPR2/RRAGC/PLCB2/CYTH4/FNBP1/NFKB1/ATM/PIK3R1/FOXO1/TRADD/TNFRSF1A/TLR5/NLRP3/BCL2L1/CAPNS1/MAPK1/MAPK8/TNIP1/ITPR1/NAIP/HCLS1/ARHGEF2/TECPR1/IKBKB/MYD88/WASF2/RIPK2/FBXW11/BCL2/TAB2/BECN1/UBB/PLCG2/PIK3CA/PRKCD/ACTR2/PIK3CD/BAX/ARPC2/CYTH2/ARPC1B/ARPC4/U2AF1L4/RELA/MAPK13	4.97471005336743
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	12/1440	19/9376	4.11228070175439	HEXB/GNS/IDS/HEXA/GUSB/NAGLU/GLB1/GALNS/HPSE/HGSNAT/SGSH/ARSB	5.78433317581385
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	47/1440	160/9376	1.91263888888889	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/ITGB2/HLA-DQA1/HLA-DMB/HLA-E/PTPRC/ALCAM/HLA-DQA2/HLA-F/HLA-DRB5/CD86/CD4/ICAM1/SDC2/HLA-C/PTPRF/CD99/CD58/ITGAM/SPN/HLA-DOA/ESAM/CADM1/CD40/JAM2/SIGLEC1/SELPLG/ICAM2/SDC3/MAG/CLDN19/ITGA4/ITGAL/CD22/CD99L2/PVR/PDCD1LG2/ITGB7/GLG1/CLDN23	4.95968145188813
Human Diseases	Immune disease	hsa05310	Asthma	16/1440	32/9376	3.25555555555556	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/FCER1G/HLA-DMA/HLA-DQB1/PRG2/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-DOA/TNF/CD40/IL10	5.4441258667902
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	43/1440	142/9376	1.9716744913928	DUSP1/JUN/NCF2/GSTO1/CYBA/IL1B/SQSTM1/ICAM1/HMOX1/FOS/NFE2L2/SDC2/CTSL/KLF2/MMP9/RAC2/MEF2A/VEGFA/MGST2/TNF/MEF2C/BMPR2/NFKB1/PIK3R1/IL1R2/HSP90AA1/MAP3K5/CCL2/TNFRSF1A/PDGFB/MAPK8/GSTT1/ARHGEF2/IKBKB/IL1A/SUMO3/BCL2/PIK3CA/PIK3CD/GSTM4/GSTA3/RELA/MAPK13	4.96976774924512
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	26/1440	69/9376	2.45346215780998	FCER1G/ALOX5AP/LCP2/ALOX5/SYK/RAC2/BTK/TNF/MAP2K3/LYN/VAV1/KRAS/PIK3R1/PDPK1/MAPK1/MAPK8/VAV3/INPP5D/SOS1/LAT/PLA2G4C/PLCG2/PIK3CA/MAP2K1/PIK3CD/MAPK13	5.16166092756813
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	21/1440	50/9376	2.73466666666667	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/CXCR4/TNFSF13B/HLA-DQA2/HLA-DRB5/CD86/HLA-DOA/CD40/IL10/ITGA4/LTBR/ITGB7/IL15/IL15RA	5.23865000881211
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	75/1440	298/9376	1.63870246085011	CCL3/CXCL2/CXCR4/CXCL16/CSH1/CXCL3/IL18/TNFSF13B/IL1B/IL1RN/EBI3/GDF15/TNFSF10/CSF2RB/CSH2/CD4/TNFRSF14/CCL4/IL6ST/IFNGR2/CCL20/CCL18/TGFBR1/OSM/TNFSF12/TGFBR2/INHA/TNFRSF1B/IL2RG/TNF/CSF2RA/BMPR2/CD40/IL6R/IL7R/CCL5/IL10/IFNGR1/CCL7/IL13RA1/CSF1R/CSF3R/TGFB2/IL1R2/CXCL10/IL4R/CCL2/TNFRSF1A/IL10RA/IL27RA/IL17RE/CXCL9/IL2RB/CSF1/IL16/XCR1/CCR1/LTBR/TNFSF14/ACKR3/IL1A/IL1RAP/IL10RB/CCL23/TNFRSF10A/CCR5/LTB/FAS/IL15/OSMR/RELT/TNFSF9/PRLR/IL12RB1/IL15RA	4.77284891510579
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	26/1440	70/9376	2.4184126984127	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/ITGB2/HLA-DQA1/HLA-DMB/HLA-E/HLA-DQA2/HLA-F/HLA-DRB5/CD86/ICAM1/BID/HLA-C/RAC2/HLA-DOA/CD40/ABL2/SNTB1/ITGAL/EIF4G3	5.07383291205809
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	27/1440	75/9376	2.344	GSTO1/CDKN1A/BID/BIRC3/MGST2/ERCC1/ATM/PIK3R1/MAP3K5/BCL2L1/PDPK1/SLC31A1/MAPK1/PMAIP1/GSTT1/XIAP/BCL2/PIK3CA/PIK3CD/BAX/BIRC2/ATP7A/BBC3/GSTM4/FAS/XPA/GSTA3	4.97772767114708
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	25/1440	68/9376	2.3937908496732	BCL2A1/SPI1/FCGR1A/CD14/ITGAM/CEBPA/STAT5A/CSF1R/RUNX1/KRAS/NFKB1/PIK3R1/STAT3/RARA/MAPK1/SOS1/DUSP6/IKBKB/PIK3CA/MAP2K1/PIK3CD/TCF7L2/RELA/TCF7/CEBPE	4.91348837348342
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	55/1440	205/9376	1.74688346883469	HLA-B/HLA-A/NFKBIA/JUN/HLA-E/GSN/ATP6V0D1/CDKN1A/HLA-F/IL6ST/REL/HLA-C/CREB5/SYK/C3/STAT5A/PRKACB/LYN/YWHAG/UBR4/CDK6/KRAS/NFKB1/PIK3R1/TRADD/NFKB2/VAC14/STAT3/MAPK1/EGR2/PMAIP1/RBL2/MAPKAPK2/LTBR/EP300/CREBBP/USP7/PIK3CA/SP100/RB1/PIK3CD/CCND2/BAX/CCR5/IRF7/DDB1/JAK1/EGR3/GTF2E2/PRKACA/HDAC7/GTF2B/ATF6B/RELA/ATP6V0D2	4.60561345864777
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	42/1440	144/9376	1.89907407407407	NFKBIA/CXCL2/C5AR1/LY96/CXCL3/C1QB/C1QA/IL1B/C1QC/C3AR1/PRKAG2/CD14/C3/C2/CPT1A/TLR4/TNF/FOXO3/MAP2K3/LPIN2/IRAK1/NFKB1/FOXO1/TRADD/MAP3K5/TNFRSF1A/MAPK8/ALDH3A2/IKBKB/MYD88/ACADM/TAB2/LPIN1/FAS/ACOX1/TICAM1/TCF7L2/IKBKE/RELA/MAPK13/MLYCD/TCF7	4.6312142966589
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	18/1440	42/9376	2.79047619047619	FTL/FTH1/SAT1/CYBB/HMOX1/PRNP/MAP1LC3B/ACSL1/SAT2/ACSL3/TFRC/ACSL5/ATG7/PCBP1/STEAP3/SLC11A2/SLC40A1/ACSL6	4.95365038237066
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	37/1440	122/9376	1.97468123861566	JUNB/CSH1/GNAI2/CSH2/FOS/CREB5/STAT1/ADCY7/IRS2/SOCS3/STAT5A/PRKACB/ITPR2/MAP2K3/GNAQ/SOCS1/PLCB2/KRAS/PIK3R1/JAK2/STAT3/MAPK1/MAPK8/SOS1/ITPR1/EP300/CREBBP/PRKCB/PLCG2/PIK3CA/MAP2K1/PIK3CD/MAP3K1/IGFBP3/PRKACA/ATF6B/MAPK13	4.61576647996079
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	20/1440	50/9376	2.60444444444444	ITGB2/CD81/CD36/IL18/IL1B/ICAM1/SDC2/LRP1/TLR4/TNF/CD40/TLR2/HGF/GYPC/IL10/TGFB2/CCL2/ITGAL/THBS3/MYD88	4.84538215009267
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	25/1440	70/9376	2.32539682539683	NFKBIA/CD36/PRKAG2/ACSL1/TNFRSF1B/IRS2/CPT1A/SOCS3/TNF/ACSL3/NFKBIE/ACSL5/POMC/NFKB1/TRADD/TNFRSF1A/JAK2/STAT3/MAPK8/IKBKB/PCK2/AGRP/RXRA/RELA/ACSL6	4.74110394087792
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	33/1440	105/9376	2.04634920634921	JUN/SQSTM1/GABARAPL1/GABARAPL2/MAP1LC3B/MITF/MRAS/GABARAP/PINK1/FOXO3/UBC/TFEB/SMURF2/KRAS/RAB7A/RAB5C/AMFR/BCL2L1/NBR1/RAB5B/MAPK8/OPTN/RAB5A/BECN1/UBB/CITED2/HIF1A/TFE3/FIS1/EIF2AK3/CCZ1B/NLRX1/RELA	4.5927632937342
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	44/1440	156/9376	1.83646723646724	NFKBIA/CD81/CDKN1A/BID/NR1H3/STAT1/CFLAR/SCARB1/SOCS3/TNF/OAS2/MX2/YWHAG/CDK6/KRAS/NFKB1/PIK3R1/TRADD/CXCL10/PIAS1/CLDN19/TNFRSF1A/STAT3/MAPK1/STAT2/SOS1/IKBKB/RSAD2/PPP2CB/PIK3CA/RXRA/OAS1/RB1/MAP2K1/PIK3CD/BAX/IRF7/FAS/JAK1/CLDN23/TYK2/TICAM1/IKBKE/RELA	4.487576117762
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	21/1440	55/9376	2.48606060606061	PSAP/ASAH1/HEXB/HEXA/ACER3/UGCG/CERS6/SGMS2/GLA/GLB1/B4GALT5/ARSA/SPHK1/NEU1/GALC/CERK/SMPD1/SGMS1/SGPL1/SGPP1/DEGS1	4.70817576031731
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	35/1440	116/9376	1.96455938697318	ITGB2/CXCR4/NCF2/CYBA/GNAI2/CYBB/MSN/ICAM1/CD99/MMP9/RAC2/ITGAM/RAP1A/ESAM/JAM2/VAV1/PIK3R1/RASSF5/CLDN19/ITGA4/ITGAL/NCF4/CD99L2/VAV3/SIPA1/PRKCB/PLCG2/PIK3CA/ARHGAP35/RAP1B/PIK3CD/CLDN23/RHOH/MAPK13/PTK2B	4.45264968242813
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	30/1440	94/9376	2.07801418439716	NFKBIA/JUN/CXCL2/S100A9/FOSB/CXCL3/JUND/IL1B/S100A8/TNFAIP3/FOS/CCL20/MMP9/CEBPB/PTGS2/TNF/CCL7/NFKB1/HSP90AA1/TRADD/CXCL10/CCL2/IL17RE/MAPK1/MAPK8/IKBKB/TAB2/IKBKE/RELA/MAPK13	4.47438834151534
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	32/1440	103/9376	2.02286947141316	FN1/ITGB2/CXCL2/CXCL3/HSPB1/IL1B/CD14/ITGAM/TLR4/TNF/TLR2/IL10/PRKACB/GNA15/GNAQ/PLCB2/RAB7A/NFKB1/TGFB2/RAB5C/PIK3R1/IL1R2/RAB5B/CD1D/PRDX1/RAB5A/PRKCB/PIK3CA/PIK3CD/PRKACA/LAMB2/RELA	4.44625896613145
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	28/1440	87/9376	2.09553001277139	JUN/GADD45B/CDKN1A/EREG/FOS/TGFBR1/RAC2/TGFBR2/GADD45G/RALGDS/AREG/KRAS/TGFB2/PIK3R1/SMAD3/MAPK1/MAPK8/SOS1/PMAIP1/APC/BCL2/PIK3CA/MAP2K1/PIK3CD/BAX/BBC3/TCF7L2/TCF7	4.37285905399499
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	20/1440	54/9376	2.41152263374486	HLA-DRA/HLA-B/HLA-A/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-E/HLA-DQA2/HLA-F/HLA-DRB5/CD86/HLA-C/HLA-DOA/CD40/IL10/FAS	4.43094369850227
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	52/1440	204/9376	1.65969498910675	FN1/TIMP3/PLAUR/CD44/CDKN1A/IGF2/HBEGF/MSN/HSPG2/SDC2/CTSL/MMP9/MRAS/PTPN6/VEGFA/TLR4/TNF/PLAU/TLR2/CAMK2D/HGF/PRKACB/ITPR2/VAV1/CBL/KRAS/TGFB2/PIK3R1/TIAM1/PDPK1/HPSE/STAT3/MAPK1/VAV3/SOS1/ITPR1/HCLS1/CAMK2G/PRKCB/PLCG2/PIK3CA/DDX5/FLNA/HIF1A/MAP2K1/PIK3CD/GPC3/FAS/ITGB5/PRKACA/WNT2B/MAPK13	4.05781553666067
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	14/1440	32/9376	2.84861111111111	BID/BIRC3/TNFRSF1A/BCL2L1/MAPK8/PMAIP1/XIAP/BCL2/BECN1/BAX/BIRC2/BBC3/BIRC6/BIRC7	4.46190365067596
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	25/1440	77/9376	2.11399711399711	NFKBIA/GADD45B/CDKN1A/TGFBR1/TGFBR2/GADD45G/STAT5A/CBL/CDK6/RUNX1/KRAS/NFKB1/TGFB2/PIK3R1/BCL2L1/SMAD3/MAPK1/SOS1/IKBKB/PIK3CA/RB1/MAP2K1/PIK3CD/BAX/RELA	4.18097296310807
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	32/1440	109/9376	1.91151885830785	NFKBIA/CD36/PRKAG2/PTPRF/CREB5/MLXIP/NR1H3/SLC27A1/IRS2/CPT1A/SOCS3/TNF/RPS6KA1/NFKB1/PIK3R1/FOXO1/RPS6KA3/TNFRSF1A/PDPK1/STAT3/MAPK8/IKBKB/RPS6KA2/PCK2/PRKCB/PPARGC1B/PIK3CA/PRKCD/PIK3CD/PYGB/PTPN1/RELA	4.07732547150452
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	19/1440	52/9376	2.37905982905983	APOE/APOC1/NPC2/LIPA/ABCA1/CD36/CYP27A1/LPL/TSPO/LRP1/NCEH1/MYLIP/SCARB1/SOAT1/APOC2/ANGPTL4/PLTP/NPC1/STARD3	4.24765956276039
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	32/1440	110/9376	1.89414141414141	SERPINE1/CDKN1A/CYBB/HMOX1/IFNGR2/VEGFA/EPAS1/PFKFB3/TLR4/IL6R/CAMK2D/TFRC/IFNGR1/HK3/FLT1/NFKB1/PIK3R1/STAT3/EGLN2/MAPK1/CAMK2G/LTBR/EP300/CREBBP/BCL2/PRKCB/PLCG2/PIK3CA/HIF1A/MAP2K1/PIK3CD/RELA	4.01811590403741
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	23/1440	71/9376	2.10923317683881	FOS/STAT1/IRF1/SOCS3/FOXO3/STAT5A/SOCS1/KRAS/NFKB1/PIK3R1/JAK2/STAT3/MAPK1/MAPK8/SOS1/PIK3CA/MAP2K1/PIK3CD/CCND2/PRLR/RELA/MAPK13/SOCS6	3.99631663692887
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	23/1440	73/9376	2.05144596651446	GADD45B/CDKN1A/GADD45G/FOXO3/HGF/STAT5A/CDK6/KRAS/PIK3R1/RASSF5/PDPK1/STAT3/MAPK1/SOS1/PRKCB/PLCG2/PIK3CA/STK4/RXRA/RB1/MAP2K1/PIK3CD/BAX	3.84151854056143
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	56/1440	238/9376	1.53202614379085	NFKBIA/JUN/C5AR1/RPS4Y1/C1QB/C1QA/IL1B/CYBB/C1QC/HBEGF/CFD/C3AR1/IL6ST/FOS/FCGR2A/SYK/C3/CASP1/C2/STAT1/TLR4/TNF/OAS2/MX2/IL6R/TLR2/NRP1/IRAK1/NFKB1/PIK3R1/CXCL10/TLR7/CCL2/TNFRSF1A/NLRP3/STAT3/MAPK1/STAT2/MAPK8/TLR8/IKBKB/MYD88/ADAM17/IFIH1/PRKCB/TAB2/PLCG2/PIK3CA/OAS1/PIK3CD/JAK1/TYK2/ADAR/IKBKE/RELA/MAPK13	3.54129356631754
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	22/1440	70/9376	2.04634920634921	JUN/CDKN1A/VEGFA/EPAS1/RAP1A/HGF/KRAS/TGFB2/PIK3R1/PDGFB/EGLN2/MAPK1/SOS1/ARNT2/EP300/CREBBP/PIK3CA/HIF1A/RAP1B/TFE3/MAP2K1/PIK3CD	3.74291702733739
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	27/1440	93/9376	1.89032258064516	JUN/HBEGF/MAP3K2/EGR1/ADCY7/CAMK2D/PRKACB/ITPR2/MAP2K3/GNAQ/PLCB2/KRAS/MAPK1/MAPK8/SOS1/ITPR1/CAMK2G/PLD1/PLA2G4C/PRKCB/MAP3K3/PRKCD/MAP2K1/MAP3K1/PRKACA/MAPK13/PTK2B	3.67545188619903
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	23/1440	75/9376	1.99674074074074	GADD45B/SERPINE1/CDKN1A/BID/CD82/ZNF385A/GADD45G/CDK6/ATM/SESN3/BCL2L1/RRM2B/PMAIP1/STEAP3/ZMAT3/BCL2/TNFRSF10A/CCND2/BAX/BBC3/FAS/IGFBP3/SESN1	3.69159521290537
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	9/1440	18/9376	3.25555555555556	HEXB/HEXA/FUCA1/MANBA/GLB1/NEU1/AGA/MAN2B2/MAN2B1	4.08003900805638
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	20/1440	62/9376	2.10035842293907	NOTCH2/ATXN1/NUMB/TLE6/LFNG/HES1/MFNG/PTCRA/ADAM17/RFNG/EP300/CREBBP/NCSTN/NRARP/DTX4/PSEN2/APH1A/NOTCH1/MAML2/TLE3	3.70278038827642
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	36/1440	139/9376	1.6863309352518	CTSD/HSPA1A/HSPA1B/JUN/GNAI2/HBEGF/FOS/CREB5/MMP9/ADCY7/HSPA6/PRKACB/POMC/ITPR2/GNAQ/PLCB2/KRAS/NCOA1/PIK3R1/HSP90AA1/FKBP5/RARA/MAPK1/KRT14/SOS1/ITPR1/NCOA3/NCOA2/BCL2/PIK3CA/PRKCD/MAP2K1/PIK3CD/KCNJ5/PRKACA/ATF6B	3.47249442722606
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	29/1440	106/9376	1.78134171907757	NFKBIA/CDKN1A/CREB5/MMP9/PLAU/KRAS/NFKB1/PIK3R1/IL1R2/HSP90AA1/FOXO1/PDGFB/PDPK1/MAPK1/SOS1/IKBKB/EP300/CREBBP/BCL2/PIK3CA/RB1/MAP2K1/PIK3CD/FOLR3/FOLR2/PDGFC/TCF7L2/RELA/TCF7	3.4460385695336
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	17/1440	51/9376	2.17037037037037	ATP6V0D1/ATP6V0E1/ATP6V0B/ATP6V1F/ATP6V1G1/ATP6V1B2/ATP6AP1/ATP6V1A/ATP6V0A1/PRKACB/ATP6V1C1/TCIRG1/TJP1/ATP6V1H/PLCG2/PRKACA/ATP6V0D2	3.5698505990729
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	24/1440	83/9376	1.88273092369478	NFKBIA/PYCARD/SAMHD1/IL18/IL1B/IFI16/CCL4/CASP1/POLR3GL/DNASE2/CCL5/TREX1/NFKB1/CXCL10/NLRP3/IKBKB/PCBP1/MLKL/IRF7/RIPK3/DNASE2B/ADAR/IKBKE/RELA	3.44076865569011
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	27/1440	99/9376	1.77575757575758	JUN/FOS/GPCPD1/RAC2/WAS/RALGDS/KRAS/PIK3R1/PDGFB/PDPK1/MAPK1/MAPK8/RHEB/SOS1/PLD1/CHKB/WASF2/PLA2G4C/PRKCB/PIK3CA/HIF1A/MAP2K1/PIK3CD/DGKH/CHKA/PDGFC/SLC44A5	3.30526206442779
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	11/1440	28/9376	2.55793650793651	ATP6V0D1/ATP6V0E1/ATP6V1F/ATP6V1G1/ATP6V1B2/ATP6V1A/ATP6V0A1/ATP6V1C1/TCIRG1/SLC12A7/ATP6V0D2	3.51670122707922
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	33/1440	130/9376	1.65282051282051	NFKBIA/JUN/GNAI2/ARRB2/FOS/TGFBR1/CREB5/MMP9/ADCY7/TGFBR2/VEGFA/PRKACB/GNA15/PLCB2/VEGFB/KRAS/NFKB1/PIK3R1/ARRB1/GNGT2/MAPK1/MAPK8/SOS1/EDNRB/PIK3CA/GNB4/MAP2K1/PIK3CD/PRKACA/GNG7/ATF6B/RELA/MAPK13	3.19267402233326
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	20/1440	67/9376	1.94361525704809	RAP1A/CAMK2D/RPS6KA1/PRKACB/ITPR2/GNAQ/PLCB2/KRAS/RPS6KA3/MAPK1/ITPR1/CAMK2G/RPS6KA2/EP300/CREBBP/PRKCB/RAP1B/MAP2K1/PPP3CB/PRKACA	3.30177059247336
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	76/1440	362/9376	1.36697360343769	SPP1/FN1/SGK1/CSH1/CDKN1A/IGF2/CSH2/EREG/CREB5/OSM/SYK/MCL1/VEGFA/PIK3AP1/SGK3/IL2RG/NR4A1/TLR4/IL6R/PKN1/FOXO3/TLR2/AREG/IL7R/HGF/CSF1R/FLT1/PIK3R5/YWHAG/VEGFB/CDK6/KRAS/CSF3R/NFKB1/PIK3R1/HSP90AA1/IL4R/ITGA4/LPAR6/BCL2L1/PDGFB/PDPK1/JAK2/GNGT2/MAPK1/THBS3/RHEB/SOS1/IL2RB/CSF1/IKBKB/RBL2/PCK2/ITGA3/BCL2/PPP2CB/PIK3CA/ITGA1/RXRA/GNB4/MAP2K1/ITGB7/PIK3CD/CCND2/LPAR2/DDIT4/JAK1/OSMR/PRLR/ITGB5/GNG7/PDGFC/LAMB2/PPP2R5E/ATF6B/RELA	3.03316746883969
Organismal Systems	Immune system	hsa04611	Platelet activation	32/1440	126/9376	1.65361552028219	FCER1G/VAMP8/GNAI2/FERMT3/LCP2/FCGR2A/APBB1IP/TBXAS1/SYK/GNA13/ADCY7/SNAP23/BTK/RAP1A/PTGS1/PRKACB/PIK3R5/ITPR2/GNAQ/PLCB2/LYN/PIK3R1/MAPK1/ITPR1/PLA2G4C/PLCG2/PIK3CA/ARHGAP35/RAP1B/PIK3CD/PRKACA/MAPK13	3.14631946399082
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	12/1440	33/9376	2.36767676767677	VAMP8/STX11/STX4/VAMP5/SNAP23/VAMP2/STX7/STX8/STX3/VAMP4/STX16/VAMP7	3.3524578014383
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	31/1440	122/9376	1.65446265938069	NFKBIA/JUN/PTPRC/CD4/FOS/LCP2/PTPN6/TNF/NFKBIE/IL10/VAV1/KRAS/NFKB1/PIK3R1/MAP3K8/PDPK1/MAPK1/MAPK8/VAV3/SOS1/IKBKB/NFATC3/LAT/PPP2CB/PIK3CA/MAP2K1/PIK3CD/PPP3CB/PPP2R5E/RELA/MAPK13	3.09931769061841
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	31/1440	122/9376	1.65446265938069	MED13L/NOTCH2/ATP1B1/STAT1/SLC16A10/PLCD3/PRKACB/PLCB2/KRAS/NCOA1/PIK3R1/FOXO1/PDPK1/MAPK1/RHEB/MED13/NCOA3/NCOA2/EP300/CREBBP/PRKCB/PLCG2/RCAN1/PIK3CA/HIF1A/RXRA/MAP2K1/THRA/PIK3CD/PRKACA/NOTCH1	3.09931769061841
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	52/1440	232/9376	1.45938697318008	TMSB4X/FN1/ITGB2/RGCC/CXCR4/GSN/ITGAX/MSN/IQGAP2/NCKAP1L/MRAS/GNA13/RAC2/ITGAM/SSH2/VAV1/BRK1/KRAS/LIMK1/PIK3R1/CYFIP1/BAIAP2/TIAM1/ITGA4/ITGAL/PDGFB/ARHGEF6/PIP4K2A/MAPK1/VAV3/SOS1/GNA12/ITGA3/ARHGEF7/WASF2/APC/DIAPH2/PIK3CA/ITGA1/SSH1/SPATA13/ARHGAP35/MAP2K1/ACTR2/ITGB7/PIK3CD/LPAR2/ARPC2/ARPC1B/ITGB5/PDGFC/ARPC4	3.01800958120827
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	51/1440	227/9376	1.46284875183554	NFKBIA/JUN/SOD2/NCF2/GSTO1/CYBA/HMOX1/FOS/NFE2L2/AHR/AKR1A1/VEGFA/MGST2/CAT/FOXO3/HGF/ABL2/KRAS/NFKB1/PIK3R1/MAP3K5/SLC25A5/MT-ND2/PDPK1/CYP1B1/MAPK1/MAPK8/SOS1/GSTT1/SDHD/IKBKB/PPIF/PLD1/EPHX1/NDUFB5/SLC26A2/UQCRB/PIK3CA/HIF1A/PRKCD/MAP2K1/PIK3CD/NDUFB1/GSTM4/PTPN1/MT-ND4/UQCRC2/GSTA3/RELA/MAPK13/MT-ND3	3.00698503254659
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	25/1440	93/9376	1.75029868578256	FN1/NFKBIA/GADD45B/CDKN1A/BIRC3/PTGS2/GADD45G/CDK6/NFKB1/PIK3R1/BCL2L1/MAX/IKBKB/ITGA3/XIAP/BCL2/PIK3CA/RXRA/RB1/PIK3CD/BAX/BIRC2/LAMB2/RELA/BIRC7	3.09740175058104
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	18/1440	60/9376	1.95333333333333	HSPB1/RAC2/VEGFA/MAPKAPK3/PTGS2/KRAS/PIK3R1/SPHK1/MAPK1/MAPKAPK2/PLA2G4C/PRKCB/PLCG2/PIK3CA/MAP2K1/PIK3CD/PPP3CB/MAPK13	3.15552567625777
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	22/1440	79/9376	1.81322081575246	ATP6V0D1/ATP6V0E1/ATP6V0B/ATP6V1F/ATP6V1G1/ATP6V1B2/AP2S1/SLC6A2/SLC1A3/ATP6V1A/ATP6V0A1/VAMP2/ATP6V1C1/TCIRG1/ATP6V1H/AP2B1/NAPA/SLC17A8/AP2A2/STX3/CLTC/ATP6V0D2	3.09183757928412
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	22/1440	80/9376	1.79055555555556	VEGFA/IL6R/AXL/FOXO3/HGF/KRAS/PIK3R1/BCL2L1/PDGFB/JAK2/STAT3/MAPK1/SOS1/BCL2/PRKCB/PLCG2/PIK3CA/MAP2K1/PIK3CD/BAX/JAK1/PDGFC	3.02479109386483
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	7/1440	15/9376	3.03851851851852	HEXB/HEXA/ST3GAL5/GLB1/B3GALT4/ST6GALNAC6/ST3GAL2	3.36562110713645
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	52/1440	238/9376	1.42259570494865	IGF2/REL/MRAS/RAC2/VEGFA/RASGRP3/RAP1A/RASGRF2/RALGDS/HGF/ABL2/PRKACB/CSF1R/FLT1/VEGFB/KRAS/NFKB1/RAB5C/PIK3R1/RASSF5/TIAM1/BCL2L1/PDGFB/GNGT2/RAB5B/MAPK1/MAPK8/SHOC2/SOS1/RASA1/CSF1/IKBKB/PLD1/RAB5A/LAT/PLA2G4C/RASA3/PRKCB/PLCG2/PIK3CA/STK4/RAP1B/RASA4/GNB4/MAP2K1/RASAL2/PIK3CD/PRKACA/GNG7/PDGFC/RGL2/RELA	2.81289832944071
NA	NA	hsa04517	IgSF CAM signaling	63/1440	299/9376	1.37190635451505	ITGB2/CD84/CD48/TUBA1A/ITGAX/CD86/MSN/ICAM1/LCP2/MBP/PTPRF/TUBB2A/PTPN6/DOK2/ITGAM/PMP22/NRP2/RAP1A/ESAM/CADM1/SLAMF7/JAM2/DOK1/LYN/VAV1/EPB41L3/RAPGEF2/NRP1/CSK/ICAM2/CRTAM/MAG/PIK3R1/FOXO1/BAIAP2/TRIO/ITGA4/TJP1/ITGAL/EPB41L2/PDPK1/MAPK1/MAPK8/VAV3/INPP5D/GLDN/RASA1/PVR/IL1RAP/PRKCB/PLCG2/CABLES1/PIK3CA/RAP1B/TUBA4A/MAP2K1/ACTR2/PIK3CD/ARPC2/ARPC1B/ARPC4/PLXNA1/MAPK13	2.78396698086344
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	34/1440	142/9376	1.55899843505477	UBE2L6/BIRC3/HERC1/SOCS3/UBC/UBE2D1/UBE2E2/SOCS1/CBL/SMURF2/PIAS1/UBE2A/UBE2W/UBE2B/ANAPC16/WWP1/XIAP/FBXW11/UBB/UBE2J1/UBE2R2/UBA7/SYVN1/ANAPC13/BIRC2/DDB1/MAP3K1/UBE2Q1/CUL5/BIRC6/UBE2G2/BIRC7/WWP2/KLHL9	2.85907721054978
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	48/1440	217/9376	1.44024577572965	JUN/KLF4/GSTO1/GNAI2/ARRB2/FOS/CREB5/NOTCH2/AHR/ADCY7/VEGFA/BCL6/MGST2/STAT5A/RPS6KA1/MIR29A/PRKACB/KRAS/NFKB1/PIK3R1/HSP90AA1/RPS6KA3/ARRB1/CYP1B1/JAK2/STAT3/MAPK1/VDR/SOS1/GSTT1/RPS6KA2/EPHX1/XIAP/BCL2/PRKCB/PIK3CA/RXRA/RB1/MAP2K1/PIK3CD/GSTM4/PRKACA/IKBKE/KPNA3/GSTA3/ATF6B/KPNA4/RELA	2.79490525074029
Human Diseases	Cancer: specific types	hsa05214	Glioma	20/1440	76/9376	1.71345029239766	GADD45B/CDKN1A/CAMK1/GADD45G/CAMK2D/CAMK1D/CDK6/KRAS/PIK3R1/PDGFB/MAPK1/SOS1/CAMK2G/PRKCB/PLCG2/PIK3CA/RB1/MAP2K1/PIK3CD/BAX	2.66008244327326
NA	NA	hsa04518	Integrin signaling	35/1440	154/9376	1.47979797979798	SPP1/FN1/ITGB2/FBN1/FERMT3/ITGAX/ICAM1/LIMS1/PARVG/C3/RAC2/ITGAM/VEGFA/PARVB/HGF/FLT1/VEGFB/ICAM2/PIK3R1/ITGA4/ITGAL/PDGFB/ARHGEF6/THBS3/LIMS2/ITGA3/PIK3CA/ITGA1/FLNA/ITGB7/PIK3CD/CCND2/ITGB5/PDGFC/LAMB2	2.55724460573356
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	34/1440	149/9376	1.48575689783743	FCER1G/SYK/MRAS/GNA13/ADCY7/CYTH1/RALGDS/PIK3R5/PLCB2/CYTH4/KRAS/PIK3R1/SPHK1/LPAR6/AGPAT3/PDGFB/MAPK1/RHEB/SOS1/GNA12/PLD1/PLA2G4C/AGPAT2/PLCG2/AGPAT4/PIK3CA/MAP2K1/PIK3CD/DGKH/LPAR2/CYTH2/PDGFC/AGPAT1/PTK2B	2.54593847876818
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	17/1440	62/9376	1.78530465949821	HSPA1A/HSPA1B/SOD2/PRKAG2/ADCY7/IRS2/CAT/HSPA6/FOXO3/PRKACB/KRAS/PIK3R1/FOXO1/CRYAB/PIK3CA/PIK3CD/PRKACA	2.64260320218685
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/1440	30/9376	2.17037037037037	IL1B/ABCC3/TNF/MTHFR/NFKB1/IKBKB/ABCC5/FOLR3/FOLR2/RELA	2.73487267541476
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	19/1440	73/9376	1.69467275494673	CXCR4/SAMHD1/BST2/ELL2/CD4/MDFIC/MX2/APOBEC3C/APOBEC3G/AFF4/SERINC3/APOBEC3A/EP300/ELL/RANBP2/CREBBP/PDCD6IP/CCR5/MAP1S	2.53802701492796
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/1440	157/9376	1.45152158527955	JUN/IL1B/FOS/PRKAG2/BID/MLXIP/NR1H3/IRS2/SOCS3/TNF/IL6R/CEBPA/NFKB1/PIK3R1/DDIT3/MAP3K5/TNFRSF1A/MAPK8/ERN1/MAP3K11/SDHD/IKBKB/IL1A/NDUFB5/UQCRB/PIK3CA/RXRA/PIK3CD/BAX/NDUFB1/FAS/UQCRC2/EIF2AK3/RELA/MAPK13	2.43025860902533
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	24/1440	99/9376	1.57845117845118	IL1B/PTGER4/ADCY7/TRPV2/CAMK2D/PRKACB/ITPR2/MAP2K3/GNAQ/PLCB2/PIK3R1/MAPK8/ITPR1/CAMK2G/PLA2G4C/IL1RAP/PRKCB/PLCG2/PIK3CA/PRKCD/PTGER2/PIK3CD/PRKACA/MAPK13	2.46460079283287
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	16/1440	59/9376	1.76572504708098	GADD45B/CDKN1A/GADD45G/FOXO3/KRAS/PIK3R1/PDPK1/MAPK1/SOS1/APC/PIK3CA/MAP2K1/PIK3CD/BAX/TCF7L2/TCF7	2.5131989290133
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	35/1440	158/9376	1.44233473980309	SGK1/ATP6V1F/ATP6V1G1/ATP6V1B2/RRAGD/LAMTOR4/FNIP2/ATP6V1A/TNF/RPS6KA1/RRAGC/ATP6V1C1/KRAS/LPIN2/CAB39/PIK3R1/RPS6KA3/TNFRSF1A/PDPK1/ATP6V1H/MAPK1/RHEB/SOS1/FNIP1/IKBKB/RPS6KA2/LAMTOR3/PRKCB/PIK3CA/MAP2K1/LPIN1/PIK3CD/DDIT4/WNT2B/MAPKAP1	2.38851127275443
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	22/1440	90/9376	1.5916049382716	SOD2/PRKAG2/CREB5/ADCY7/IRS2/CAT/FOXO3/PRKACB/KRAS/NFKB1/PIK3R1/FOXO1/SESN3/RB1CC1/RHEB/PIK3CA/PIK3CD/BAX/SESN1/PRKACA/ATF6B/RELA	2.40217564924705
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	17/1440	65/9376	1.70290598290598	SPP1/ARRB2/ITPR2/KISS1/GNAQ/PLCB2/KRAS/PIK3R1/ARRB1/MAPK1/ITPR1/KCNN4/PRKCB/PIK3CA/MAP2K1/PIK3CD/KCNJ5	2.42226586785238
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	11/1440	37/9376	1.93573573573574	IL18/IL1B/ICAM1/TNF/IL10/GNAQ/PLCB2/APOL1/MYD88/PRKCB/FAS	2.42923731999905
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	41/1440	195/9376	1.36900284900285	ITGB2/FCGR3A/C5AR1/NCF2/CYBA/FPR3/FCGR1A/CYBB/AQP9/FCGR2A/SYK/CLEC7A/C3/CASP1/RAC2/ITGAM/FPR1/TLR4/TLR2/SIGLEC9/SELPLG/PLCB2/NFKB1/PIK3R1/TLR7/ITGAL/SLC25A5/ATG7/NCF4/MAPK1/TLR8/PPIF/PRKCB/PLCG2/PIK3CA/MAP2K1/PIK3CD/CAMP/HDAC7/RELA/MAPK13	2.21803342197928
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	31/1440	140/9376	1.44174603174603	SPP1/SERPINE1/GNAI2/PRKAG2/EGR1/TGFBR1/MAP1LC3B/KLF2/MRAS/GNA13/MEF2A/ADCY7/SLC8A1/MEF2C/PRKACB/PIK3R5/ITPR2/GNAQ/PLCB2/KRAS/SPHK1/SMAD3/GNGT2/MEF2D/MAPK1/ITPR1/BECN1/GNB4/MAP2K1/PRKACA/GNG7	2.24316266129916
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/1440	72/9376	1.62777777777778	NFKBIA/TNF/ZNFX1/NFKB1/TRADD/CXCL10/CYLD/MAPK8/IKBKB/IFIH1/IRF7/MAP3K1/RNF125/ADAR/IKBKE/NLRX1/RELA/MAPK13	2.27773602340684
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	37/1440	174/9376	1.3845466155811	HSPA1A/HSPA1B/DNAJB1/MAN1A1/NFE2L2/PPP1R15A/HERPUD1/HSPA6/UBE2D1/OS9/HSP90AA1/DDIT3/MAP3K5/AMFR/HSPH1/SEC31A/FBXO6/DNAJC5B/MAPK8/ERN1/SEC24D/UBXN6/EDEM3/SEL1L/CRYAB/BCL2/UBE2J1/DNAJB2/DNAJC5/MBTPS1/SYVN1/BAX/SEC24A/BAG1/EIF2AK3/ATF6B/UBE2G2	2.1809643054985
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	21/1440	88/9376	1.55378787878788	ITGB2/PLAUR/SERPINE1/C5AR1/SERPINA1/SERPINE2/C1QB/C1QA/A2M/ITGAX/C1QC/CFD/SERPING1/C3AR1/C3/C2/ITGAM/VSIG4/PLAU/CD46/CD59	2.22325733149903
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1440	83/9376	1.56894243641232	PCGF5/JARID2/UBE2D1/PHC2/MAX/DCAF7/SFMBT2/ASXL2/PHF1/EP300/KDM2A/CREBBP/USP7/PHC3/FBRS/BCORL1/MBD6/L3MBTL4/MGA/BMI1	2.21766253968501
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	20/1440	83/9376	1.56894243641232	SOD2/ACSL1/PIPOX/CAT/ACSL3/ACSL5/ABCD1/GSTK1/SCP2/DHRS4/PRDX1/PEX11B/HSD17B4/NUDT19/ABCD4/DECR2/ACOX1/PEX2/MLYCD/ACSL6	2.21766253968501
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	26/1440	115/9376	1.47207729468599	GNAI2/FOS/CREB5/ADCY7/CAMK2D/PRKACB/PIK3R5/ITPR2/GNAQ/PLCB2/KRAS/PIK3R1/KCNJ2/JAK2/GNGT2/MAPK1/ITPR1/CAMK2G/BCL2/PRKCB/PIK3CA/GNB4/MAP2K1/PIK3CD/PRKACA/GNG7	2.16969728526318
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	23/1440	99/9376	1.51268237934905	JUN/CDKN1A/HBEGF/FOS/NOTCH2/MMP9/ADCY7/PRKACB/KRAS/PIK3R1/MAPK1/MAPK8/SOS1/NCOA3/BCL2/PIK3CA/RB1/MAP2K1/PIK3CD/BAX/PRKACA/NOTCH1/MAPK13	2.1843803689679
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	6/1440	16/9376	2.44166666666667	HEXB/HEXA/GLA/GBGT1/NAGA/ST3GAL2	2.45840244239123
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	21/1440	89/9376	1.53632958801498	GNAI2/TUBA1A/MAP3K2/TUBB2A/ADCY7/PRKACB/ITPR2/GNAQ/PLCB2/KRAS/TJP1/PDGFB/MAPK1/SOS1/ITPR1/PRKCB/GJA1/TUBA4A/MAP2K1/PRKACA/PDGFC	2.16548456145582
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	30/1440	138/9376	1.41545893719807	FBP1/RHOQ/PRKAG2/PTPRF/IRS2/SOCS3/HK3/PRKACB/SOCS1/CBL/KRAS/PIK3R1/FOXO1/PRKAR1A/PDPK1/INPPL1/MAPK1/MAPK8/RHEB/SOS1/IKBKB/PCK2/PIK3CA/MAP2K1/PIK3CD/PRKAR1B/PYGB/PHKB/PTPN1/PRKACA	2.09432812377097
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	43/1440	212/9376	1.3206498951782	ITGB2/GNAI2/LCP2/APBB1IP/MRAS/RAC2/ADCY7/ITGAM/EVL/DOCK4/VEGFA/FPR1/RASGRP3/RAP1A/RALGDS/HGF/CSF1R/FLT1/MAP2K3/GNAQ/PLCB2/VAV1/VEGFB/RAPGEF2/KRAS/PIK3R1/RASSF5/TIAM1/ITGAL/PDGFB/MAPK1/VAV3/SIPA1/CSF1/LAT/PRKCB/PIK3CA/RAP1B/MAP2K1/PIK3CD/LPAR2/PDGFC/MAPK13	2.01151162664874
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/1440	65/9376	1.60273504273504	LPL/MGLL/AKR1A1/GK/GLA/LPIN2/AGPAT3/ALDH3A2/AGPAT2/AGPAT4/LPIN1/DGKH/MBOAT1/PNPLA2/DGAT1/AGPAT1	2.07706941878587
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	20/1440	86/9376	1.51421188630491	JUN/CDKN1A/HBEGF/EREG/AREG/CAMK2D/STAT5A/ABL2/CBL/KRAS/PIK3R1/MAPK1/MAPK8/SOS1/CAMK2G/PRKCB/PLCG2/PIK3CA/MAP2K1/PIK3CD	2.04056077776035
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	41/1440	203/9376	1.31505199781062	SPP1/FN1/JUN/PARVG/BIRC3/RAC2/VEGFA/PARVB/RAP1A/ZYX/EMP1/HGF/FLT1/VAV1/VEGFB/PIK3R1/ITGA4/PDGFB/PDPK1/MAPK1/MAPK8/THBS3/VAV3/SOS1/ITGA3/XIAP/BCL2/PRKCB/PIK3CA/ITGA1/FLNA/ARHGAP35/RAP1B/MAP2K1/ITGB7/PIK3CD/CCND2/BIRC2/ITGB5/PDGFC/LAMB2	1.9330389936368
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	22/1440	98/9376	1.46167800453515	NR4A2/CREB5/ATP1B1/ADCY7/SCARB1/CAMK1/NR4A1/CAMK2D/PRKACB/POMC/ITPR2/GNAQ/CAMK1D/PLCB2/DAGLB/ITPR1/CAMK2G/PRKCB/ATP2B1/KCNJ5/PRKACA/ATF6B	1.95700120300154
Organismal Systems	Digestive system	hsa04978	Mineral absorption	15/1440	61/9376	1.60109289617486	FTL/FTH1/HMOX1/ATP1B1/SLC8A1/ATOX1/SLC31A1/VDR/CYBRD1/SLC11A2/SLC30A1/ATP2B1/SLC40A1/ATP7A/TRPM7	2.00623192947785
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/1440	22/9376	2.07171717171717	AOC1/HNMT/ALDH3B1/MAOA/ALDH3A2/CNDP2/AMDHD1	2.14367479494934
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	32/1440	154/9376	1.35295815295815	JUN/RGS2/GNAI2/CDKN1A/FOS/PRKAG2/ADCY7/CAMK1/PTGS2/MEF2C/CAMK2D/PRKACB/PIK3R5/ITPR2/GNAQ/CAMK1D/PLCB2/KRAS/KCNJ2/MAPK1/ITPR1/CACNA2D4/CAMK2G/NFATC3/CD38/PLA2G4C/PRKCB/RCAN1/MAP2K1/KCNJ5/PPP3CB/PRKACA	1.88120911447347
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1440	37/9376	1.75975975975976	GADD45B/CDKN1A/GADD45G/KRAS/MAPK1/RXRA/MAP2K1/BAX/TCF7L2/TCF7	1.97239102041001
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/1440	47/9376	1.66241134751773	IRS2/SOCS3/TNF/HK3/SOCS1/PIK3R1/MAPK1/MAPK8/IKBKB/PIK3CA/PRKCD/PIK3CD	1.93921160141562
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1440	10/9376	2.60444444444444	PAPSS2/TST/ETHE1/PAPSS1	2.1622886154729
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1440	53/9376	1.59706498951782	AP2S1/ATP1B1/SLC8A1/PRKACB/GNAQ/PLCB2/AP2B1/VDR/PRKCB/ATP2B1/AP2A2/CLTC/PRKACA	1.85672571931256
NA	NA	hsa03272	Virion - Hepatitis viruses	12/1440	48/9376	1.62777777777778	CD81/CD9/HSPG2/CHMP1B/LAMP2/SCARB1/LAMP1/TGOLN2/CLDN19/IST1/PDCD6IP/CLDN23	1.85736964261114
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/1440	43/9376	1.6656330749354	ACSL1/CPT1A/ACSL3/ACSL5/HADHB/ACAA2/ALDH3A2/ACADM/ACADS/ACOX1/ACSL6	1.86347917280018
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1440	59/9376	1.54500941619586	GNAI2/MGLL/ADCY7/IRS2/PTGS2/FABP4/PTGS1/PRKACB/PIK3R1/PTGER3/PIK3CA/PIK3CD/PNPLA2/PRKACA	1.7887844812013
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	34/1440	170/9376	1.30222222222222	GADD45B/GSTO1/CDKN1A/IGF2/HMOX1/NFE2L2/TGFBR1/TGFBR2/MGST2/GADD45G/HGF/CDK6/KRAS/TGFB2/PIK3R1/BCL2L1/SMAD3/MAPK1/SOS1/GSTT1/APC/PRKCB/PLCG2/PIK3CA/RB1/MAP2K1/PIK3CD/BAX/GSTM4/ARID1B/TCF7L2/WNT2B/GSTA3/TCF7	1.69387525894177
Organismal Systems	Nervous system	hsa04730	Long-term depression	14/1440	60/9376	1.51925925925926	GNAI2/GNA13/ITPR2/GNAQ/PLCB2/LYN/KRAS/MAPK1/ITPR1/GNA12/PLA2G4C/PRKCB/PPP2CB/MAP2K1	1.71874397751103
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	22/1440	104/9376	1.37735042735043	PLD3/GPCPD1/LPCAT2/PLA2G15/SGMS2/LPIN2/AGPAT3/ETNK1/PLD1/GDPD5/CHKB/PLA2G4C/AGPAT2/AGPAT4/PLD4/LPIN1/SGMS1/DGKH/LPGAT1/MBOAT1/CHKA/AGPAT1	1.6483174601716
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	23/1440	110/9376	1.36141414141414	EMP3/ID2/FBN1/HAMP/NOG/TGFBR1/LTBP1/TGFBR2/TNF/BMPR2/TFRC/SMURF2/TGFB2/SMAD7/BAMBI/SKIL/SMAD3/MAPK1/EP300/CREBBP/PPP2CB/ZFYVE16/TMEM53	1.62413225312312
Human Diseases	Cancer: specific types	hsa05218	Melanoma	16/1440	73/9376	1.42709284627093	GADD45B/CDKN1A/MITF/GADD45G/HGF/CDK6/KRAS/PIK3R1/PDGFB/MAPK1/PIK3CA/RB1/MAP2K1/PIK3CD/BAX/PDGFC	1.56040837070286
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1440	41/9376	1.58807588075881	CDKN1A/TYMP/HBEGF/MMP9/VEGFA/DAPK1/KRAS/MAPK1/RB1/MAP2K1	1.60743784714417
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	13/1440	57/9376	1.48499025341131	PPT1/ACSL1/CPT1A/ACSL3/ACSL5/HADHB/SCP2/ACAA2/ACADM/HSD17B4/ACADS/ACOX1/ACSL6	1.56441451776421
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/1440	12/9376	2.17037037037037	ASGR1/CD46/NPC1/FCGR2B	1.72802210474719
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	35/1440	184/9376	1.23852657004831	CXCR4/GNAI2/PLXNC1/RAC2/DPYSL2/SSH2/EPHB2/SEMA3C/BMPR2/CAMK2D/PLXNB2/RHOD/SEMA4A/NRP1/KRAS/NTN4/LIMK1/PIK3R1/PDPK1/MAPK1/SEMA5A/RASA1/CAMK2G/NFATC3/CDK5/EPHB6/PLCG2/PIK3CA/SSH1/FES/PIK3CD/EFNB2/PPP3CB/EFNB1/PLXNA1	1.39189579085465
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	20/1440	98/9376	1.32879818594104	PLCD3/ITPR2/PLCB2/PI4K2A/PIK3R1/INPPL1/PIP4K2A/INPP5D/ITPR1/MTMR14/PRKCB/IPMK/SACM1L/PLCG2/PIK3CA/PIK3CD/DGKH/MTMR6/MTMR3/ITPK1	1.39373857777614
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/1440	59/9376	1.4346516007533	TYMP/DPYD/ENTPD1/TK2/DCTD/NME3/NME4/RRM2B/UPP1/NT5E/ENTPD4/NT5C2/CDA	1.4265772572953
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	50/1440	275/9376	1.18383838383838	HSPA1A/HSPA1B/NCF2/CYBA/C1QB/C1QA/IL1B/TUBA1A/CYBB/C1QC/EGR1/PRNP/TUBB2A/CREB5/RAC2/TNF/HSPA6/CCL5/PRKACB/ITPR2/PIK3R1/DDIT3/SLC25A5/MT-ND2/NCF4/MAPK1/MAPK8/ITPR1/SDHD/PPIF/IL1A/NDUFB5/UQCRB/PIK3CA/PRKCD/TUBA4A/PIK3CD/BAX/NDUFB1/PSMD9/PPP3CB/MT-ND4/UQCRC2/PRKACA/EIF2AK3/NOTCH1/KLC1/ATF6B/MAPK13/MT-ND3	1.31802618316625
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/1440	133/9376	1.27284878863826	GNAI2/ARRB2/FOS/CREB5/COMT/CAMK2D/PRKACB/ITPR2/GNAQ/PLCB2/ARRB1/GNGT2/MAPK8/ITPR1/MAOA/CAMK2G/PRKCB/PPP2CB/GNB4/KCNJ5/PPP3CB/PRKACA/GNG7/PPP2R5E/ATF6B/MAPK13	1.34991812529136
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1440	93/9376	1.33022700119474	TGFBR1/PTPRF/PTPN6/RAC2/TGFBR2/WAS/RAP1A/SMURF2/BAIAP2/TJP1/SMAD3/MAPK1/WASF2/EP300/CREBBP/RAP1B/PTPN1/TCF7L2/TCF7	1.36325134372707
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/1440	93/9376	1.33022700119474	LYZ/CST3/ATP1B1/ADCY7/VAMP2/SLC4A2/PRKACB/KCNMA1/ITPR2/GNAQ/PLCB2/BST1/ITPR1/CD38/KCNN4/PRKCB/ATP2B1/CAMP/PRKACA	1.36325134372707
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1440	38/9376	1.54210526315789	HEXB/HEXA/RENBP/HK3/GNPDA1/CHIT1/UAP1L1/AMDHD2/UGDH	1.42631201925487
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1440	38/9376	1.54210526315789	SGK1/ATP1B1/KRAS/PIK3R1/PDPK1/MAPK1/PRKCB/PIK3CA/PIK3CD	1.42631201925487
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	9/1440	38/9376	1.54210526315789	PTPRC/CD4/BTK/IL2RG/CD40/IL7R/CIITA/BLNK/RFX5	1.42631201925487
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1440	49/9376	1.46167800453515	JUN/FOSB/GNAI2/CREB5/PRKACB/NFKB1/MAOA/CDK5/PRKACA/ATF6B/RELA	1.3801690699804
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	20/1440	101/9376	1.28932893289329	GNAI2/MITF/ADCY7/CAMK2D/PRKACB/POMC/GNAQ/PLCB2/KRAS/MAPK1/CAMK2G/EP300/CREBBP/PRKCB/EDNRB/MAP2K1/PRKACA/TCF7L2/WNT2B/TCF7	1.24526461550261
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1440	34/9376	1.53202614379085	PRKAG2/BHLHE41/DBP/NR1D2/PER1/BHLHE40/FBXW11/PER3	1.32378835314287
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	29/1440	155/9376	1.21820788530466	GNAI2/CDKN1A/NCEH1/CREB5/AHR/ADCY7/SCARB1/RAP1A/NR4A1/CAMK2D/PRKACB/POMC/ITPR2/GNAQ/PLCB2/CDK6/MAPK1/ITPR1/CAMK2G/KMT2A/APC/RAP1B/RB1/MAP2K1/PRKACA/TCF7L2/WNT2B/ATF6B/TCF7	1.16684543973197
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	37/1440	205/9376	1.17517615176152	CTSD/NCF2/CD36/CYBA/CYBB/TGFBR1/MMP9/RAC2/TGFBR2/MPC2/PDK4/CAMK2D/MPC1/PLCB2/NFKB1/TGFB2/PIK3R1/SLC25A5/MT-ND2/NCF4/SMAD3/MAPK8/SDHD/CAMK2G/PPIF/NDUFB5/PRKCB/UQCRB/PIK3CA/PRKCD/PIK3CD/NDUFB1/MT-ND4/UQCRC2/RELA/MAPK13/MT-ND3	1.08021354850142
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/1440	76/9376	1.28508771929825	GNAI2/ATP1B1/ADCY7/CAMK2D/SLC4A2/PRKACB/ITPR2/GNAQ/PLCB2/KCNJ2/ITPR1/CAMK2G/PRKCB/HRH2/PRKACA	1.06294277958665
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1440	20/9376	1.62777777777778	NPL/CYB5R4/GMDS/UAP1L1/UGDH	1.19713157116815
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/1440	82/9376	1.27046070460705	GSTO1/TYMP/MGST2/DPYD/GUSB/TK2/NME3/NME4/RRM2B/UPP1/GSTT1/CES2/CDA/GSTM4/CES1/GSTA3	1.04779379423066
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1440	42/9376	1.3952380952381	AOC1/IL4I1/KYNU/CAT/CYP1B1/MAOA/ALDH3A2/HAAO/KMO	1.09349197270416
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/1440	31/9376	1.47025089605735	DPYD/ALDH3B1/ALDH3A2/ACADS/CNDP2/ACOX1/MLYCD	1.11708669833793
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1440	65/9376	1.30222222222222	NCEH1/CREB5/ADCY7/SCARB1/NR4A1/PRKACB/POMC/ITPR2/GNAQ/PLCB2/ITPR1/PRKACA/ATF6B	1.04148007158634
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	30/1440	166/9376	1.17670682730924	RGS2/GNAI2/CREB5/ATP1B1/GNA13/MEF2A/ADCY7/IRS2/SLC8A1/MEF2C/PIK3R5/KCNMA1/ITPR2/GNAQ/PLCB2/GTF2I/SLC25A5/MEF2D/MAPK1/ITPR1/GNA12/NFATC3/PPIF/KCNMB1/EDNRB/ATP2B1/MAP2K1/ADORA3/PPP3CB/ATF6B	0.978461209481968
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	20/1440	107/9376	1.21703011422638	FBP1/PRKAG2/CREB5/SIK1/CPT1A/CAMK2D/PRKACB/ITPR2/GNAQ/PLCB2/FOXO1/ITPR1/CAMK2G/PCK2/EP300/CREBBP/PYGB/PHKB/PPP3CB/PRKACA	0.961748464116703
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	15/1440	78/9376	1.25213675213675	PLCD3/PLCB2/PI4K2A/INPPL1/PIP4K2A/INPP5D/MTMR14/IPMK/SACM1L/PLCG2/PIK3CA/PIK3CD/MTMR6/MTMR3/ITPK1	0.952477530762217
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1440	21/9376	1.55026455026455	DSE/CHST11/CSGALNACT2/CHST13/CHPF2	1.07528934210609
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1440	85/9376	1.22562091503268	TYMP/ENTPD1/TK2/DCTD/LACC1/NME3/NME4/RRM2B/UPP1/NT5E/AMPD3/ENTPD4/NT5C2/AMPD2/CDA/AK3	0.890068935150001
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1440	44/9376	1.33181818181818	ARHGDIB/CREB5/STX4/VAMP2/PRKACB/RAB5C/RAB5B/RAB5A/PRKACA	0.939734577836976
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	21/1440	115/9376	1.18898550724638	DUSP1/GNAI2/ALOX5/PTGS2/PTGS1/PRKACB/ITPR2/GNAQ/PLCB2/KRAS/GNGT2/MAPK1/ITPR1/MAOA/PLA2G4C/PRKCB/GNB4/MAP2K1/KCNJ5/PRKACA/GNG7	0.868589416695616
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/1440	97/9376	1.20824742268041	GNAI2/FOS/ADCY7/CAMK2D/PRKACB/GNAQ/PLCB2/GNGT2/MAPK1/PER1/ITPR1/CAMK2G/PRKCB/GNB4/PER3/KCNJ5/PRKACA/GNG7	0.878174798265742
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	30/1440	170/9376	1.14901960784314	JUN/TUBA1A/MSN/PRKAG2/WAS/RAP1A/YBX3/JAM2/PRKACB/RAPGEF2/RUNX1/TIAM1/MAP3K5/CLDN19/TJP1/MAPK8/HCLS1/ARHGEF2/LLGL2/CD1D/PPP2CB/TUBA4A/ACTR2/ARPC2/ARPC1B/MAP3K1/NF2/CLDN23/PRKACA/ARPC4	0.835215309339801
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/1440	56/9376	1.27896825396825	ARRB2/PRKACB/SMURF2/ARRB1/SPOP/SPOPL/FBXW11/BCL2/CCND2/PRKACA/CSNK1G1	0.891880967382532
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	39/1440	226/9376	1.123598820059	NFKBIA/JUN/GNAI2/FOS/CREB5/ATP1B1/RAC2/ADCY7/RAP1A/CAMK2D/PRKACB/POMC/VAV1/SUCNR1/NFKB1/PIK3R1/TIAM1/PDE10A/PTGER3/MAPK1/MAPK8/VAV3/PDE4B/CAMK2G/PDE4A/PLD1/EP300/CREBBP/HCAR2/ATP2B1/PIK3CA/RAP1B/PTGER2/MAP2K1/PIK3CD/ACOX1/PRKACA/RELA/PDE4C	0.801168843909909
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1440	116/9376	1.17873563218391	GLUL/GNAI2/HOMER3/SLC1A3/ADCY7/PRKACB/ITPR2/GNAQ/PLCB2/GNGT2/MAPK1/ITPR1/SLC17A8/PLD1/PLA2G4C/SLC38A2/PRKCB/GNB4/PPP3CB/PRKACA/GNG7	0.825088809077546
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	20/1440	110/9376	1.18383838383838	GNAI2/ADCY7/CPEB4/RPS6KA1/PRKACB/CPEB2/KRAS/PIK3R1/HSP90AA1/RPS6KA3/MAPK1/MAPK8/ANAPC16/RPS6KA2/PIK3CA/MAP2K1/PIK3CD/ANAPC13/PRKACA/MAPK13	0.826137702818356
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1440	69/9376	1.22673107890499	CTSB/GNAI2/PTGER4/PRKACB/KCNMA1/ITPR2/GNAQ/PLCB2/KCNJ2/ITPR1/PTGER2/PPP3CB/PRKACA	0.805187080214484
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1440	17/9376	1.53202614379085	CYP27A1/HSD3B7/SCP2/HSD17B4	0.9352091898925
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1440	17/9376	1.53202614379085	LAMP2/LAMP1/NRP2/TFRC	0.9352091898925
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	43/1440	254/9376	1.10227471566054	CXCR4/P2RX4/ADCY7/VEGFA/CAMK1/SLC8A1/PTAFR/ORAI2/ORAI3/CAMK2D/P2RX7/HGF/PLCD3/PRKACB/GNA15/FLT1/ITPR2/GNAQ/CAMK1D/PLCB2/MCOLN1/TFEB/VEGFB/TPCN1/PTGER3/SPHK1/SLC25A5/PDGFB/ITPR1/CAMK2G/NFATC3/PPIF/CD38/PRKCB/EDNRB/ATP2B1/PLCG2/PHKB/HRH2/PPP3CB/PRKACA/PDGFC/PTK2B	0.703892211492839
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/1440	149/9376	1.13616703952274	GNAI2/MGLL/ADCY7/PTGS2/PRKACB/ITPR2/GNAQ/PLCB2/MT-ND2/GNGT2/MAPK1/MAPK8/DAGLB/ITPR1/SLC17A8/NDUFB5/PRKCB/GNB4/NDUFB1/ABHD6/KCNJ5/MT-ND4/PRKACA/GNG7/MAPK13/MT-ND3	0.713675723400476
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/1440	59/9376	1.21393596986817	GPX1/GSTO1/MGST2/ANPEP/LAP3/GSTK1/PGD/RRM2B/GSTT1/GSTM4/GSTA3	0.702162809483304
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1440	18/9376	1.44691358024691	ACSL1/ACSL3/ACSL5/ACSL6	0.808414953977236
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1440	18/9376	1.44691358024691	TCN2/PRDX1/LMBRD1/ABCD4	0.808414953977236
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1440	91/9376	1.14481074481074	GNAI2/ARRB2/ADCY7/PRKACB/GRK4/PDE10A/ARRB1/GNGT2/PDE4B/PDE4A/PRKCB/GNB4/KCNJ5/PRKACA/GNG7/PDE4C	0.591284621937377
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	63/1440	388/9376	1.05721649484536	APOE/LPL/IL1B/TUBA1A/CYBB/BID/LRP1/TUBB2A/IRS2/PTGS2/TNF/SLC39A11/RTN4/ITPR2/GNAQ/PLCB2/KRAS/NFKB1/SLC39A13/PIK3R1/DDIT3/MAP3K5/TNFRSF1A/SLC25A5/MT-ND2/MAPK1/MAPK8/RB1CC1/ERN1/ITPR1/ADAM10/CSF1/SDHD/IKBKB/PPIF/SNCA/ADAM17/CDK5/SLC11A2/APC/IL1A/NDUFB5/NCSTN/UQCRB/BECN1/PIK3CA/TUBA4A/MAP2K1/PIK3CD/PSEN2/BACE1/NDUFB1/FAS/PSMD9/APH1A/PPP3CB/MT-ND4/UQCRC2/WNT2B/EIF2AK3/KLC1/RELA/MT-ND3	0.490310997533171
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	25/1440	148/9376	1.09984984984985	JUN/GADD45B/CDKN1A/FOS/NOTCH2/GADD45G/HES1/CDK6/KRAS/NCOA1/PIK3R1/NFKB2/MAPK1/SOS1/NCOA3/APC/PIK3CA/RB1/MAP2K1/PIK3CD/BAX/TCF7L2/WNT2B/NOTCH1/TCF7	0.521543498105527
NA	NA	hsa04981	Folate transport and metabolism	6/1440	31/9376	1.26021505376344	SLCO2B1/ABCC3/MTHFR/ABCC5/FOLR3/FOLR2	0.618144011427848
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	44/1440	268/9376	1.06898839137645	DUSP1/GNAI2/TUBA1A/NFE2L2/TUBB2A/UBE2L6/SLC39A11/PINK1/CAMK2D/UBC/PRKACB/ITPR2/SLC39A13/DDIT3/MAP3K5/SLC25A5/BCL2L1/MT-ND2/MAPK8/LRRK2/ERN1/ITPR1/MAOA/SDHD/CAMK2G/PPIF/SNCA/SLC11A2/NDUFB5/UQCRB/UBB/UBE2J1/TUBA4A/UBA7/BAX/NDUFB1/PSMD9/MT-ND4/UQCRC2/PRKACA/EIF2AK3/KLC1/MT-ND3/UBE2G2	0.488087807665483
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/1440	86/9376	1.13565891472868	CREB5/ATP1B1/ADCY7/CAMK2D/VAMP2/PRKACB/KCNMA1/GNAQ/PLCB2/CAMK2G/KCNMB1/KCNN4/PRKCB/PRKACA/ATF6B	0.538338898655369
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/1440	50/9376	1.172	SAT1/AOC1/SAT2/LAP3/OAT/PYCR1/MAOA/ALDH3A2/CNDP2	0.51943570417891
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/1440	75/9376	1.12859259259259	GPX1/CREB5/ATP1B1/ADCY7/ASGR1/PRKACB/ITPR2/GNAQ/PLCB2/ITPR1/PRKCB/PRKACA/ATF6B	0.476264067301109
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1440	38/9376	1.19941520467836	NAMPT/SIRT2/BST1/NNT/NT5E/CD38/NT5C2	0.524673569111014
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1440	32/9376	1.22083333333333	GABARAPL1/GABARAPL2/GABARAP/ATG7/BECN1/PPP2CB	0.533014786218991
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1440	69/9376	1.13236714975845	JUN/FOSB/FOS/CREB5/CAMK2D/PRKACB/MAOA/CAMK2G/PRKCB/PPP3CB/PRKACA/ATF6B	0.470073707341126
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1440	26/9376	1.25213675213675	SCARB1/TCN2/SLC19A2/LMBRD1/ABCD4	0.548381856449588
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1440	63/9376	1.136860670194	PIPOX/SETDB2/KMT2C/KMT2E/PLOD2/ALDH3A2/ASH1L/PLOD3/KMT2A/PHYKPL/PRDM2	0.464269539007344
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/1440	51/9376	1.14901960784314	PLA2G7/PLD3/LPCAT2/TMEM86A/PLD1/PLA2G4C/PLD4/PAFAH1B2/PAFAH2	0.454537939271382
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	29/1440	178/9376	1.06079900124844	JUN/NOTUM/SFRP1/RAC2/CAMK2D/MMP7/TLE6/PRKACB/PLCB2/BAMBI/SMAD3/MAPK8/CAMK2G/NFATC3/APC/ANKRD6/FBXW11/EP300/CREBBP/PRKCB/CTNND2/CCND2/PPP3CB/PRKACA/TCF7L2/WNT2B/PORCN/TLE3/TCF7	0.348839614867464
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	76/1440	480/9376	1.03092592592593	GPX1/IL1B/SQSTM1/TUBA1A/CYBB/BID/PRNP/TUBB2A/MAP1LC3B/UBE2L6/ATXN1/TNFRSF1B/PTGS2/TNF/CAT/HIP1/PINK1/CAMK2D/UBC/ITPR2/MAP2K3/GNAQ/PLCB2/C9orf72/KRAS/NFKB1/DDIT3/MAP3K5/TNFRSF1A/SLC25A5/BCL2L1/MT-ND2/MAPK1/MAPK8/LRRK2/OPTN/RB1CC1/ERN1/ITPR1/CSF1/SDHD/CAMK2G/PPIF/SNCA/DNAH11/RAB5A/CDK5/RAB1A/APC/IL1A/NDUFB5/BCL2/PRKCB/UQCRB/BECN1/UBB/UBE2J1/TUBA4A/UBA7/MAP2K1/PSEN2/BAX/NDUFB1/FAS/SPG11/PSMD9/PPP3CB/MT-ND4/UQCRC2/WNT2B/EIF2AK3/KLC1/RELA/MAPK13/MT-ND3/UBE2G2	0.296286591304617
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1440	52/9376	1.12692307692308	ALOX5/ADCY7/SCARB1/PTGS2/PRKACB/CYP1B1/ACOT2/PLA2G4C/PRKACA	0.390937369116776
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	21/1440	128/9376	1.06822916666667	ADCY7/ENTPD1/PAPSS2/LACC1/PDE10A/NME3/NME4/RRM2B/PDE4B/NT5E/AMPD3/PDE4A/ENTPD4/NT5C2/AMPD2/AK3/PDE6H/PDE6G/PAPSS1/PDE4C/ENPP4	0.331067992896322
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	20/1440	122/9376	1.06739526411658	FBP1/CD36/PRKAG2/CREB5/IRS2/PFKFB3/CPT1A/FOXO3/CAB39/PIK3R1/FOXO1/PDPK1/RHEB/PCK2/PPP2CB/PIK3CA/PIK3CD/TBC1D1/PPP2R5E/MLYCD	0.319161576824051
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/1440	78/9376	1.08518518518519	FN1/RHOG/CBL/PIK3R1/HCLS1/WASF2/PIK3CA/ACTR2/PIK3CD/ARPC2/ARPC1B/CLTC/ARPC4	0.321797493443958
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1440	47/9376	1.10827423167849	ME2/AKR1A1/ACYP2/HAGH/ALDH3A2/PCK2/ME1/ME3	0.316973202515473
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	23/1440	143/9376	1.04724164724165	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/FCGR3A/HLA-DMB/C1QB/C1QA/HLA-DQA2/HLA-DRB5/FCGR1A/C1QC/CD86/FCGR2A/C3/C2/HLA-DOA/TNF/CD40/IL10	0.242486568647681
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/1440	144/9376	1.03996913580247	KLF4/ID2/IL6ST/BMPR2/ZFHX3/PCGF5/JARID2/KRAS/PIK3R1/SKIL/JAK2/SMAD3/STAT3/MAPK1/APC/PIK3CA/MAP2K1/PIK3CD/JAK1/WNT2B/MAPK13/BMI1/TCF7	0.20588474130358
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1440	16/9376	1.22083333333333	IL4I1/ALDH3B1/MAOA	0.376576096666865
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	25/1440	157/9376	1.03680113234253	ITGB2/SERPINE1/ID2/TGFBR1/BIRC3/TGFBR2/BMPR2/AREG/YWHAG/TGFB2/SMAD7/SMAD3/LLGL2/APC/FBXW11/PPP2CB/CCND2/LATS1/BIRC2/BBC3/NF2/TCF7L2/WNT2B/TEAD1/TCF7	0.198077504183882
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/1440	138/9376	1.03800322061192	ATP6V0D1/ATP6V0E1/ATP6V0B/ATP6V1F/ATP6V1G1/ATP6V1B2/ATP6AP1/ATP6V1A/ATP6V0A1/ATP6V1C1/TCIRG1/MT-ND2/ATP6V1H/SDHD/NDUFB5/UQCRB/LHPP/NDUFB1/MT-ND4/UQCRC2/MT-ND3/ATP6V0D2	0.191574200468972
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	22/1440	138/9376	1.03800322061192	ADCY7/CAMK2D/CPEB4/RPS6KA1/PRKACB/ITPR2/YWHAG/CPEB2/RPS6KA3/MAPK1/ITPR1/ANAPC16/CAMK2G/RPS6KA2/FBXW11/PPP2CB/MAP2K1/ANAPC13/PPP3CB/PRKACA/PPP2R5E/MAPK13	0.191574200468972
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/1440	48/9376	1.08518518518519	IL4I1/BCAT1/HADHB/ACAA2/ALDH3A2/ACADM/ACADS/IVD	0.252032458879387
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1440	29/9376	1.12260536398467	RASSF4/RASSF2/LATS1/NF2/TEAD1	0.281668579300811
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1440	23/9376	1.13236714975845	CTSA/ATP6AP2/ANPEP/PRCP	0.270728964949788
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1440	36/9376	1.08518518518519	AKR1A1/GUSB/CRYL1/DHDH/FGGY/UGDH	0.21812625286884
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1440	17/9376	1.14901960784314	PAPSS2/SEPHS2/PAPSS1	0.261950485620995
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/1440	43/9376	1.05994832041344	ABCA1/CD36/SCARB1/SLC27A1/AGPAT2/DGAT1/AGPAT1	0.167828869600016
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	11/1440	70/9376	1.0231746031746	GSTO1/MGST2/PTGS2/GSTK1/SULT1A1/CYP1B1/GSTT1/EPHX1/HSD11B1/GSTM4/GSTA3	0.0828983443554703
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1440	31/9376	1.05017921146953	AKR1A1/GUSB/HSD17B14/ALDH3A2/UGDH	0.119201324517767
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1440	150/9376	0.99837037037037	GADD45B/CDKN1A/TGFBR1/TGFBR2/GADD45G/HGF/KRAS/TGFB2/PIK3R1/SMAD3/MAPK1/SOS1/APC/BCL2/PIK3CA/RXRA/RB1/MAP2K1/PIK3CD/BAX/TCF7L2/WNT2B/TCF7	-0.00857025751107656
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1440	45/9376	1.01283950617284	ABCA1/ABCG1/ABCC3/ABCD1/ABCC5/ABCD4/ABCC10	0.0367753265070219
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1440	32/9376	1.01736111111111	GALM/HK3/GAA/GLA/GLB1	0.0419036781618702
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	12/1440	79/9376	0.989029535864979	GSTO1/MGST2/ALDH3B1/GSTK1/CYP1B1/GSTT1/EPHX1/HSD11B1/DHDH/CYP2S1/GSTM4/GSTA3	-0.0417093274272157
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1440	46/9376	0.990821256038647	FTL/FTH1/HMOX1/BLVRA/BLVRB/GUSB/ALAS1	-0.0265819847269401
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/1440	54/9376	0.964609053497942	SDS/IL4I1/SDSL/BCAT1/LACC1/MAT2A/TST/APIP	-0.111096547542623
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1440	27/9376	0.964609053497942	SCP2/ACOT2/HSD17B4/ACOX1	-0.0784436032595649
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	15/1440	102/9376	0.957516339869281	ATP1B1/ADCY7/RAP1A/SLC4A2/KCNMA1/ITPR2/GNAQ/PLCB2/BST1/ITPR1/CD38/PRKCB/RAB3D/ATP2B1/RAP1B	-0.183761497190489
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/1440	41/9376	0.952845528455284	SDS/SDSL/PIPOX/MAOA/ALAS1/BPGM	-0.128891329678841
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1440	48/9376	0.949537037037037	ATP1B1/HK3/PLCB2/PIK3R1/PRKCB/PIK3CA/PIK3CD	-0.14930183705355
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/1440	89/9376	0.951061173533084	SPP1/FN1/CD44/CD36/HSPG2/ITGA4/THBS3/ITGA3/ITGA1/ITGB7/ITGB5/CD47/LAMB2	-0.197595425533213
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1440	89/9376	0.951061173533084	GLUL/GNAI2/GABARAPL1/GABARAPL2/GABARAP/ADCY7/PRKACB/GNGT2/SLC38A2/PRKCB/GNB4/PRKACA/GNG7	-0.197595425533213
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1440	35/9376	0.93015873015873	FBP1/PFKFB3/HK3/HSD17B14/GMDS	-0.176325659888878
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1440	28/9376	0.93015873015873	PPT1/HADHB/ACAA2/ACOT2	-0.157651404983684
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1440	49/9376	0.93015873015873	GALNT7/LFNG/MFNG/PLOD3/RFNG/POFUT2/GALNT11	-0.208787855380139
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1440	21/9376	0.93015873015873	DPYD/BCAT1/ALDH3A2	-0.136479031882696
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1440	63/9376	0.93015873015873	HPGD/LTA4H/ALOX5/TBXAS1/PTGES/PTGS2/PTGS1/LTC4S/PLA2G4C	-0.236921053410964
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1440	36/9376	0.904320987654321	GALNT7/B4GALT5/B3GNT3/GALNT11/ST3GAL2	-0.244996878222248
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	47/1440	323/9376	0.947437220502236	VIM/MARCKS/TIMP3/CD44/ZEB2/CDKN1A/HMOX1/ST14/FOXP1/NOTCH2/MMP9/MCL1/VEGFA/IRS2/PTGS2/DICER1/PLAU/BMPR2/MIR29A/SOCS1/CDK6/KRAS/NFKB1/TGFB2/ATM/PIK3R1/PDGFB/CYP1B1/STAT3/MAPK1/RECK/SOS1/IKBKB/APC/EP300/CREBBP/BCL2/PRKCB/PLCG2/PIK3CA/MAP2K1/PIK3CD/SOX4/CCND2/DDIT4/NOTCH1/BMI1	-0.409495730558115
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1440	44/9376	0.887878787878788	HEXB/MAN1A1/HEXA/MGAT1/MGAT4A/MGAT2	-0.317535884748567
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1440	37/9376	0.87987987987988	IL4I1/COMT/ALDH3B1/FAH/MAOA	-0.31184047753518
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1440	31/9376	0.840143369175627	FBP1/H6PD/PGD/RBKS	-0.379741362392314
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	21/1440	154/9376	0.887878787878788	GNAI2/CREB5/ATP1B1/ADCY7/SLC8A1/CAMK2D/PRKACB/PIK3R5/GNAQ/PLCB2/MAPK1/CACNA2D4/CAMK2G/BCL2/PPP2CB/ATP2B1/PRKACA/PPP2R5E/ATF6B/MAPK13/KCNE1	-0.597587686813527
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/1440	134/9376	0.874626865671642	GNA13/ADCY7/PRKACB/KCNMA1/ITPR2/GNAQ/PLCB2/MAPK1/ITPR1/GNA12/KCNMB1/PLA2G4C/ADM/PRKCB/PRKCD/MAP2K1/ARHGEF11/PRKACA	-0.622644211720333
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/1440	63/9376	0.826807760141093	GADD45B/CDKN1A/GADD45G/APC/BAX/TCF7L2/WNT2B/TCF7	-0.587516349620118
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/1440	71/9376	0.825352112676056	HK3/KRAS/PIK3R1/MAPK1/PIK3CA/HIF1A/MAP2K1/PIK3CD/SCO2	-0.629216897123676
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1440	86/9376	0.8328165374677	SLC8A1/SNTB1/ITGA4/CACNA2D4/ITGA3/ITGA1/GJA1/ITGB7/ITGB5/TCF7L2/TCF7	-0.663438604628617
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	32/1440	235/9376	0.88661938534279	PRKAG2/MGLL/CREB5/ACSL1/ADCY7/CPT1A/ACSL3/ACSL5/RPS6KA1/PRKACB/MAP2K3/KRAS/COX14/MAP3K5/SLC25A20/RPS6KA3/MT-ND2/RHEB/SOS1/SDHD/RPS6KA2/NDUFB5/UQCRB/NDUFB1/ARID1B/PNPLA2/MT-ND4/UQCRC2/PRKACA/MAPK13/MT-ND3/ACSL6	-0.749793961330444
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1440	36/9376	0.723456790123457	HK3/GAA/GYG1/PYGB	-0.708120009313336
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/1440	44/9376	0.73989898989899	POLD4/PARP4/MPG/MBD4/POLL	-0.736626038943748
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/1440	67/9376	0.777446102819237	FBP1/GALM/AKR1A1/ALDH3B1/HK3/ALDH3A2/BPGM/PCK2	-0.778730427961205
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/1440	233/9376	0.866285169289461	VIM/FN1/FBN1/BGN/FBLN1/FMNL2/HSPG2/SDC2/ATP1B1/FMNL1/SYNE1/ZYX/SNTB1/SDC3/ITGA4/MYOZ1/FMNL3/THBS3/AMPD3/ITGA3/DIAPH2/CAPZA2/ITGA1/PDLIM7/AMPD2/ITGB7/FHL1/FBN2/ITGB5/SUN2/PLEC	-0.88039837875454
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/1440	90/9376	0.795802469135802	AQP9/NCEH1/ATP1B1/ADCY7/SCARB1/ABCC3/SLC4A2/PRKACB/EPHX1/RXRA/PRKACA	-0.829131578433769
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1440	20/9376	0.651111111111111	LIPA/SOAT1	-0.665308519197873
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/1440	105/9376	0.806137566137566	ADCY7/SLC8A1/TNF/PRKACB/SNTB1/TGFB2/ITGA4/CACNA2D4/ITGA3/ITGA1/ITGB7/ITGB5/PRKACA	-0.850924590829395
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1440	68/9376	0.766013071895425	ALDH1A1/DHRS4L2/RDH10/DHRS9/DHRS3/DHRS4/CYP2S1/DGAT1	-0.824866981339772
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/1440	37/9376	0.703903903903904	HK3/GMDS/UAP1L1/UGDH	-0.768686777124218
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/1440	144/9376	0.813888888888889	ATXN1/ITPR2/GNAQ/PLCB2/PIK3R1/MAP3K5/SLC25A5/MAPK8/RB1CC1/ERN1/ITPR1/PPIF/PRKCB/BECN1/PIK3CA/PIK3CD/PSMD9/GTF2B	-0.958675668000451
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1440	30/9376	0.651111111111111	OGDH/SDHD/PCK2	-0.815269006405287
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	14/1440	116/9376	0.785823754789272	FBP1/SDS/SDSL/ME2/CAT/HK3/H6PD/PGD/OGDH/SDHD/ME1/ME3/ACADS/ACOX1	-0.988691627597745
NA	NA	hsa04081	Hormone signaling	28/1440	219/9376	0.832470826991375	CSH1/HAMP/GNAI2/IGF2/CSH2/GNA13/ADCY7/IRS2/SLC16A10/STAT5A/PRKACB/GNA15/POMC/GNAQ/PLCB2/PIK3R1/JAK2/GNGT2/STAT3/GNA12/PIK3CA/GNB4/SLC40A1/THRA/PIK3CD/PRLR/PRKACA/GNG7	-1.06856747163588
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/1440	103/9376	0.758576051779935	SLC7A7/COL17A1/ATP1B1/SLC8A1/SLC16A10/PRCP/KCNE3/COL8A2/SLC7A8/KCNN4/SLC38A2/COL22A1	-1.04943340710843
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1440	13/9376	0.500854700854701	POLL	-0.767109223310382
NA	NA	hsa04519	Cadherin signaling	54/1440	404/9376	0.87029702970297	VIM/NFKBIA/LHFPL2/NCKAP1L/MRAS/RAC2/EVL/MYO1F/MAP2K3/YWHAG/VAV1/TAOK1/BRK1/KRAS/NFKB1/CYFIP1/TJP1/MAPK1/KRT14/MAPK8/SHOC2/VAV3/MYO1G/ADAM10/IKBKB/TMC4/TMC6/APC/ANKRD6/EP300/TMC8/CREBBP/NCSTN/GJA1/ARHGAP35/MAP2K1/ACTR2/CTNND2/PSEN2/LATS1/ARPC2/TAOK3/ARPC1B/NF2/APH1A/MYO1C/TCF7L2/ARPC4/WNT2B/RELA/MAPK13/PTK2B/TEAD1/TCF7	-1.13517293134778
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1440	23/9376	0.566183574879227	ATP1B1/PCK2	-0.887279600455874
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1440	32/9376	0.610416666666667	ACADS/ACOX1/MLYCD	-0.940318537952371
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/1440	73/9376	0.713546423135464	GSTO1/MGST2/ALDH3B1/GSTK1/MAOA/GSTT1/GSTM4/GSTA3	-1.04657468056407
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1440	24/9376	0.542592592592593	EXTL3/NDST1	-0.955702275141799
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1440	14/9376	0.465079365079365	ST3GAL2	-0.853169075858302
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/1440	99/9376	0.723456790123457	PRKAG2/SLC8A1/TNF/SNTB1/TGFB2/ITGA4/CACNA2D4/ITGA3/ITGA1/ITGB7/ITGB5	-1.17826471741176
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/1440	44/9376	0.591919191919192	TAF7/GTF2I/GTF2E2/GTF2B	-1.15571619313893
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1440	26/9376	0.500854700854701	PLA2G4C/ACOX1	-1.08561018361546
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1440	26/9376	0.500854700854701	HES1/HHEX	-1.08561018361546
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1440	46/9376	0.566183574879227	PSMB9/PSMB8/PSMB10/PSMD9	-1.25634854130485
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1440	37/9376	0.527927927927928	GLUL/IL4I1/ASRGL1	-1.22553307671326
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	18/1440	158/9376	0.741772151898734	GADD45B/CDKN1A/GADD45G/YWHAG/CDK6/TGFB2/ATM/SMAD3/ANAPC16/RBL2/EP300/CREBBP/PPP2CB/RB1/CCND2/ANAPC13/MAU2/PPP2R5E	-1.3943741484188
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1440	17/9376	0.383006535947712	GLUL	-1.08456692292202
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1440	28/9376	0.465079365079365	B3GNT3/GCNT2	-1.20746644271594
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1440	56/9376	0.581349206349206	MAN1A1/MGAT5/MGAT1/MGAT4A/MGAT2	-1.33845579031091
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	46/1440	368/9376	0.813888888888889	GPX1/SQSTM1/TUBA1A/BID/TUBB2A/MAP1LC3B/CASP1/NUP214/TNFRSF1B/TNF/CAT/PINK1/MAP2K3/C9orf72/CHCHD10/DDIT3/MAP3K5/TNFRSF1A/BCL2L1/MT-ND2/OPTN/RB1CC1/ERN1/SDHD/DNAH11/RAB5A/RAB1A/NDUFB5/RANBP2/SETX/BCL2/ANG/UQCRB/BECN1/TUBA4A/BAX/NDUFB1/SPG11/PSMD9/PPP3CB/MT-ND4/UQCRC2/EIF2AK3/KLC1/MAPK13/MT-ND3	-1.551486772202
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1440	30/9376	0.434074074074074	PIGT/B3GALT4	-1.32243210380815
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1440	19/9376	0.342690058479532	OGDH	-1.22164421075061
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	37/1440	308/9376	0.782178932178932	GPX1/SOD2/TUBA1A/AP2S1/TUBB2A/CREB5/SLC1A3/HIP1/GNAQ/PLCB2/MAP3K5/SLC25A5/MT-ND2/MAPK8/AP2B1/RB1CC1/ERN1/ITPR1/SDHD/PPIF/DNAH11/NDUFB5/EP300/CREBBP/UQCRB/BECN1/TUBA4A/AP2A2/BAX/NDUFB1/BBC3/PSMD9/CLTC/MT-ND4/UQCRC2/KLC1/MT-ND3	-1.65571483468574
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/1440	31/9376	0.420071684587814	GLUL/CAT	-1.37762673621248
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/1440	78/9376	0.584330484330484	BTG1/BTG2/PABPC1/TOB1/XRN1/CNOT6L/PATL1	-1.57024261851082
NA	NA	hsa04082	Neuroactive ligand signaling	22/1440	199/9376	0.719821328866555	GNAI2/SLC6A2/SLC1A3/P2RX4/ADCY7/P2RY11/TAC3/PRKACB/POMC/GNAQ/PLCB2/GNGT2/SLC17A8/PRKCB/AGRP/GNB4/SLC17A9/ADORA3/HRH2/OGFRL1/PRKACA/GNG7	-1.70167766303863
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1440	33/9376	0.394612794612795	BCAT1/OGDH	-1.48392888404384
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/1440	154/9376	0.676479076479076	AKR1A1/KYNU/GUSB/BCAT1/PDXK/NME3/NME4/DHRS3/MAT2A/ALDH3A2/ALAS1/HAAO/KMO/PNPO/AK3/UGDH	-1.72431350558034
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1440	23/9376	0.283091787439613	GLUL	-1.4662838831587
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1440	23/9376	0.283091787439613	POLD4	-1.4662838831587
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/1440	75/9376	0.520888888888889	GLUL/SDS/SDSL/BCAT1/PYCR1/MAT2A	-1.77446773462188
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/1440	39/9376	0.333903133903134	MTHFR/MAT2A	-1.77554657591028
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1440	27/9376	0.241152263374486	ACADS	-1.68197679547253
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/1440	28/9376	0.232539682539683	PCBD1	-1.73237396158207
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/1440	41/9376	0.317615176151762	POLD4/ATM	-1.86522050650185
Cellular Processes	Cell motility	hsa04814	Motor proteins	19/1440	194/9376	0.637686139747995	TUBA1A/TUBB2A/MYO1F/DYNLT1/MYO5A/MYO9B/MYO1G/KIFC3/DNAH11/KIF1B/KIF13A/MYO7B/CAPZA2/TUBA4A/KIF16B/KIF13B/KIF12/MYO1C/KLC1	-2.17211704517319
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/1440	63/9376	0.413403880070547	POLD4/ERCC1/DDB1/XPA	-1.98989753445673
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1440	29/9376	0.224521072796935	PDE6G	-1.78155376407763
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1440	30/9376	0.217037037037037	PLA2G4C	-1.82959520121102
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1440	66/9376	0.394612794612795	COMT/DHRS9/CYP1B1/HSD11B1	-2.10230837315279
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/1440	34/9376	0.191503267973856	POLR3GL	-2.0117029396041
NA	NA	hsa04382	Cornified envelope formation	20/1440	217/9376	0.600102406554019	S100A4/S100A10/S100A9/S100A8/COL17A1/ST14/S100A6/DST/SLC27A1/UGCG/CLDN19/TJP1/KRT14/PADI2/PPP2CB/SPRR2G/CLDN23/PCSK6/PPP2R5E/PLEC	-2.53875436244262
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1440	36/9376	0.180864197530864	POLD4	-2.0974894025866
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/1440	87/9376	0.374201787994891	ATP1B1/SLC8A1/CACNA2D4/UQCRB/UQCRC2	-2.49790270046345
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/1440	117/9376	0.445204178537512	BAZ2B/TFPT/RSF1/SMARCA1/GATAD2B/ARID1B/ZNHIT1/EPC1	-2.57223192985986
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/1440	108/9376	0.42201646090535	NUP214/SUMO3/RANBP2/TMEM33/EEF1A1/KPNA3/KPNA4	-2.57335907412704
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/1440	191/9376	0.54543339150669	FOSB/GNAI2/CREB5/PRKACB/KRAS/SLC29A3/GNGT2/MAPK1/SOS1/MAOA/GNB4/MAP2K1/PRKACA/GNG7/HDAC7/ATF6B	-2.70358910833882
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/1440	54/9376	0.241152263374486	ERCC1/HES1	-2.38211667056507
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1440	41/9376	0.158807588075881	SLC17A8	-2.29930280070761
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1440	86/9376	0.302842377260982	PRKACB/PLCB2/PKD2L1/PRKACA	-2.76654923537559
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/1440	103/9376	0.316073354908306	PABPC1/PPP2CB/SMG1/PCF11/PPP2R5E	-2.97292573774239
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	31/1440	370/9376	0.545525525525526	C5AR1/CSH1/FPR3/TSPO/CSH2/C3AR1/PTGER4/C3/P2RX4/FPR1/PTAFR/P2RY11/NR3C1/TAC3/P2RX7/POMC/KISS1/PTGER3/LPAR6/GPR35/S1PR4/UTS2/ADM/EDNRB/PTGER2/ADORA3/THRA/LPAR2/HRH2/OGFRL1/PRLR	-3.79935995973056
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/1440	243/9376	0.16076817558299	HSPA1A/HSPA1B/HSPA6/PCBP1/DDX5/U2AF1L4	-5.64604593278655
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/1440	183/9376	0.0711596842744384	NOP10/XRN1	-5.40510365446127
Genetic Information Processing	Translation	hsa03010	Ribosome	1/1440	222/9376	0.0293293293293293	RPS4Y1	-6.23460574274725
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/1440	449/9376	0.130512249443207	RGS2/ARRB2/SLC8A1/CAMK2D/PRKACB/ARRB1/CAMK2G/PRKACA/GNG7	-8.04266400569187