category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	36/454	155/9376	4.79658945573398	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/CTSS/HLA-B/HLA-DQB1/HLA-DMA/ITGB2/MSR1/OLR1/HLA-DQA1/NCF2/HLA-DMB/FCGR3A/STX7/HLA-DQA2/CTSL/ATP6V0E1/HLA-A/CD36/ATP6V1G1/ATP6V1E1/RAB5C/MARCO/CYBB/HLA-F/FCGR2A/ATP6V1B2/NCF4/FCGR1A/CD14/ATP6V1C1/ATP6V0D1/STX12/ITGAM	10.7511007197262
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	26/454	95/9376	5.65212149316021	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/ACP5/HLA-DMA/ITGB2/HLA-DQA1/HLA-DMB/CXCL2/HLA-DQA2/CXCL3/CTSL/ATP6V0E1/CD86/ATP6V1G1/ATP6V1E1/CCL3/CCL20/TNFSF13B/ATP6V1B2/IL18/ATP6V1C1/ICAM1/ATP6V0D1	10.2801137356227
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	22/454	99/9376	4.58932941752325	HLA-DRA/HLA-DRB1/KRT18/HLA-DPA1/HLA-DPB1/HLA-DQB1/C1QB/C1QA/HLA-DMA/ITGB2/HLA-DQA1/HLA-DMB/FCGR3A/HLA-DQA2/FPR3/C5AR1/C1QC/FCGR2A/C3AR1/FCGR1A/ICAM1/ITGAM	8.09859335007187
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/454	78/9376	5.0306110922851	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/ITGB2/HLA-DQA1/NCF2/HLA-DMB/FCGR3A/HLA-DQA2/NFKBIA/CYBB/FCGR2A/PTPN6/NCF4/FCGR1A/ITGAM	8.06317120654704
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/454	82/9376	4.7852154292468	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-DPB1/CTSS/HLA-B/HLA-DQB1/LGMN/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/CTSB/CTSL/HLA-A/CD4/HLA-F/TAPBPL	7.76566495048531
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/454	250/9376	2.89127753303965	VAMP8/LAPTM5/CTSS/CLTB/ACP5/CD68/HEXB/CTSD/LGMN/LIPA/CTSB/SLC29A3/CTSL/LAMTOR5/ATP6V0E1/CTSZ/SLC17A5/ATP6V1G1/ATP6V1E1/SLC15A3/SLC11A1/RRAGD/ATP6V1B2/CLTCL1/ASAH1/BLOC1S2/ATP6V1C1/VPS35/TFEB/ROGDI/CTBS/ATP6V0D1/CLTA/GNPTG/SNAP29	6.83703008275397
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/454	39/9376	6.88399412628487	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-A/CD86/HLA-F	8.3058351997706
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	28/454	181/9376	3.1947818044637	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-DPB1/CTSS/HLA-DQB1/FCER1G/CTSD/HLA-DMA/ITGB2/HLA-DQA1/HLA-DMB/FCGR3A/HLA-DQA2/BAD/LSP1/PLK3/CEBPB/RAB5C/FCGR2A/IL18/FCGR1A/CAMK2G/CD14/SYK/ATP6V0D1/ITGAM	6.72569589930168
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/454	44/9376	6.10172206647978	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-A/CD86/HLA-F	7.65135273120176
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/454	45/9376	5.96612824278022	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-A/CD86/HLA-F	7.53255909837818
Human Diseases	Immune disease	hsa05310	Asthma	11/454	32/9376	7.09911894273128	HLA-DRA/PRG2/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/FCER1G/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2	7.79575410982111
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/454	70/9376	4.42542479546885	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/ITGB2/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-A/CD86/HLA-F/ICAM1	6.48879999702646
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	29/454	224/9376	2.67369414726243	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/CDKN1A/HLA-DMA/ITGB2/HLA-DQA1/HLA-DMB/SLC25A5/HLA-DQA2/CDKN2A/SPI1/HLA-A/MSX2/CD4/NFKBIA/TGFBR1/CDKN2B/HLA-F/STAT5B/MMP7/ICAM1/NRP1/ADCY7/ANAPC13/HRAS	5.71905872543027
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/454	54/9376	4.97177353565019	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-A/CD86/HLA-F	6.60251297779569
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/454	50/9376	4.95647577092511	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/CD86/CXCR4/TNFSF13B	6.32744330187574
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	17/454	100/9376	3.51083700440529	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/CD59/CD37/CD44/CD4/CD36/FCGR1A/CD14/ITGAM	5.69404120758468
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	25/454	205/9376	2.51853443644569	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/CDKN1A/HLA-DMA/HLA-DQA1/HLA-DMB/VIM/HLA-DQA2/CD44/HLA-A/MAP2K3/PSMD7/NFKBIA/GADD45G/NEDD4/HLA-F/CDK6/TAPBPL/ICAM1/SYK/CXCL10	4.95878962662866
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/454	112/9376	3.13467589679043	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/BAD/MAP2K3/LY96/LAMC2/NFKBIA/BIRC7/ALOX5/BIRC3	5.12653751373216
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/454	76/9376	3.53257593322513	OLR1/SCP2/LPL/DBI/CYP27A1/CD36/ACADL/FABP5/FABP4/SORBS1/RXRA/CPT2/GK	5.0004633961221
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	27/454	250/9376	2.2304140969163	ARPC2/HLA-B/CLTB/SH3GLB2/SH3KBP1/HLA-A/TSG101/TGFBR1/CXCR4/EHD1/RAB5C/DAB2/NEDD4L/NEDD4/CHMP5/HLA-F/PIP5K1B/SNX3/ARRB2/CLTCL1/RAB31/EPN3/VPS35/CLTA/CYTH3/HRAS/RAB11A	4.44798716629441
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/454	88/9376	3.28554265118142	SERPINE2/C1QB/C1QA/ITGB2/SERPINE1/CD59/SERPINA1/C5AR1/C1QC/C3AR1/PLAUR/F5/A2M/ITGAM	4.85905727326988
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	18/454	138/9376	2.69373683202452	COX4I1/MT-ND2/MT-ND4L/MT-ND3/MT-ND1/MT-ND5/MT-ND4/MT-ATP6/ATP6V0E1/MT-CYB/ATP6V1G1/ATP6V1E1/UQCRB/ATP6V1B2/NDUFA13/ATP6V1C1/ATP6V0D1/NDUFAB1	4.52146268713529
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/454	205/9376	2.31705168153003	COX4I1/MT-ND2/MT-ND4L/CTSD/MT-ND3/MT-ND1/NCF2/PDK4/SLC25A5/MMP9/MT-ND5/MT-ND4/MT-ATP6/TGFBR1/CD36/MT-CYB/CYBB/UQCRB/NCF4/NDUFA13/CAMK2G/NDUFAB1/CPT2	4.30084564390355
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/454	42/9376	4.42542479546885	FTL/GPX4/HMOX1/MAP1LC3B/SLC40A1/CYBB/LPCAT3/PCBP1/STEAP3	5.01865843709015
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/454	193/9376	2.35411198100934	CXCL2/CXCL16/CXCL3/BAD/CCL18/NFKBIA/CXCL9/CXCR4/GNG12/CCL3/CCL20/VAV3/FGR/ARRB2/STAT5B/WAS/CXCR6/DOCK2/CXCL10/ADCY7/BCAR1/HRAS	4.2876901962915
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/454	180/9376	2.40939794419971	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/BAD/HLA-A/NFKBIA/HLA-F/SP100/TNFRSF14/TAPBPL/BIRC3/SYK/EIF2B1	4.30678171084505
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/454	142/9376	2.61785692126326	TYROBP/TREM2/ACP5/NCF2/FCGR3A/SQSTM1/SPI1/NFKBIA/TGFBR1/LILRB4/OSCAR/FCGR2A/LCP2/LILRB2/JUND/NCF4/FCGR1A/SYK	4.3819942509776
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	20/454	169/9376	2.44402158329641	GABARAPL1/VAMP8/GABARAPL2/MAP1LC3B/CTSD/MRAS/STX7/CTSB/CFLAR/BAD/CTSL/SQSTM1/GABARAP/DAPK1/RRAGD/C9orf72/OPTN/CALCOCO2/SNAP29/HRAS	4.27307406451541
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/454	109/9376	2.84201592369559	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/CD4/NFKBIA/TGFBR1/IL27/STAT5B/RXRA	4.36334449582343
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	24/454	227/9376	2.18346950261018	GSTA3/COX4I1/MT-ND2/HMOX1/MT-ND4L/SOD1/MT-ND3/MT-ND1/NCF2/SLC25A5/MT-ND5/MT-ND4/BAD/MT-ATP6/GSTT1/NFKBIA/MT-CYB/NFE2L2/UQCRB/EPHX2/NDUFA13/CAT/NDUFAB1/HRAS	4.07160501714241
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/454	160/9376	2.45242290748899	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/ITGB2/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-A/CD4/CD86/ALCAM/PTPRC/HLA-F/ICAM1/ITGAM	4.179884712193
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	23/454	216/9376	2.19905367922989	OLR1/NCF2/CXCL2/MMP9/CXCL3/BAD/MAP2K3/LY96/NFKBIA/CD36/NFE2L2/CYBB/CCL3/VAV3/CASP1/IL18/NCF4/CAMK2G/CD14/ICAM1/RXRA/ABCA1/HRAS	4.0216124800527
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	13/454	93/9376	2.88683624650656	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/CD4/NFKBIA/MAML2/STAT5B	4.12490513228244
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/454	105/9376	2.75359765051395	GABARAPL1/GABARAPL2/MAP1LC3B/MRAS/SQSTM1/GABARAP/RAB5C/FIS1/PINK1/AMFR/OPTN/TFEB/CALCOCO2/HRAS	4.07609004176674
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/454	157/9376	2.36774320267123	C1QB/C1QA/LIPA/DUSP2/CEBPB/CD36/RAB5C/HAVCR2/ALOX5/C1QC/PTPN6/P2RY6/PTGER4/CASP1/CAMK2G/RXRA/ABCA1/BCAR1	3.89847666496214
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/454	232/9376	2.04739480480024	FN1/GSN/ARPC2/TMSB4X/MRAS/ITGB2/MYL12B/MYL12A/PPP1R12B/RGCC/SCIN/CXCR4/GNG12/VAV3/PIP5K1B/ITGB6/CFL1/BAIAP2/IQGAP2/ITGAM/FGD3/BCAR1/HRAS	3.64391933385988
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/454	66/9376	3.1290882392204	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/IL18	3.91537391760317
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	16/454	143/9376	2.3107113151166	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/C1QB/C1QA/HLA-DMA/HLA-DQA1/HLA-DMB/FCGR3A/HLA-DQA2/CD86/C1QC/FCGR2A/FCGR1A	3.56275620188038
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/454	68/9376	3.0370562321845	BAD/SPI1/BCL2A1/PIM1/STAT5B/FCGR1A/CD14/PER2/ITGAM/HRAS	3.80287229847979
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/454	105/9376	2.55691210404867	CXCL2/CXCL3/CFLAR/LY96/NFKBIA/UBE2I/BCL2A1/GADD45G/TNFSF13B/BIRC3/CD14/ICAM1/SYK	3.61891105485853
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/454	173/9376	2.14876117236638	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/SLC25A5/HLA-DQA2/NFKBIA/CDK6/CASP1/IL18/ICAM1/CALCOCO2/CXCL10/RAB11A	3.44009585471004
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/454	28/9376	4.42542479546885	ATP6V0E1/ATP6V1G1/ATP6V1E1/ATP6V1B2/ATP6V1C1/ATP6V0D1	4.09464783878206
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/454	133/9376	2.3291709449836	GABARAPL1/GABARAPL2/FBXO32/CDKN1A/GABARAP/PLK3/FOXO4/TGFBR1/PRKAB2/CDKN2B/GADD45G/PRKAG2/HOMER3/CAT/HRAS	3.48243194786707
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/454	98/9376	2.52881416883934	GSN/ARPC2/FCGR3A/SCIN/VAV3/PTPRC/FCGR2A/PIP5K1B/CFL1/WAS/FCGR1A/SYK	3.4318082028876
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/454	157/9376	2.10466062459665	HLA-B/CDKN1A/MRAS/SERPINE1/SLC25A5/SQSTM1/CDKN2A/HLA-A/MAP2K3/TGFBR1/CDKN2B/GADD45G/HLA-F/CDK6/E2F4/HRAS	3.14861273613488
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/454	116/9376	2.31444630107854	ITGB2/NCF2/MYL12B/MMP9/MYL12A/CXCR4/CYBB/SIPA1/VAV3/NCF4/ICAM1/ITGAM/BCAR1	3.21328173247758
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	15/454	144/9376	2.15124816446402	C1QB/C1QA/CXCL2/CXCL3/MAP2K3/LY96/C5AR1/NFKBIA/PRKAB2/ACADVL/LPIN2/C1QC/C3AR1/PRKAG2/CD14	3.14039844823097
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/454	54/9376	3.0595529450155	CDO1/SMS/LDHB/SDS/IL4I1/SDSL/LACC1/AHCYL2	3.4237161121766
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	22/454	248/9376	1.83203069489839	DYNLRB1/ARPC2/SKP1/MYL12B/MYL12A/MAP2K3/LY96/NFKBIA/TXN/RAB5C/DYNLT1/ACTR1A/RAB9A/PTPRC/DYNLL2/CASP1/BIRC3/IL18/DYNLRB2/CD14/CYTH3/HRAS	2.99543450539908
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/454	33/9376	3.75490588706448	VAMP8/STX7/STX4/SNAP23/SNAP29/VAMP2	3.57604535064614
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/454	79/9376	2.61417498466514	CLTB/ATP6V0E1/ATP6V1G1/ATP6V1E1/ATP6V1B2/CLTCL1/ATP6V1C1/ATP6V0D1/CLTA/VAMP2	3.2499389135737
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/454	133/9376	2.1738928819847	TYROBP/HLA-B/FCER1G/ITGB2/FCGR3A/HLA-A/CD48/VAV3/PTPN6/LCP2/HCST/ICAM1/SYK/HRAS	3.07560294710451
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/454	56/9376	2.95028319697923	ITGB2/CXCL2/CXCL3/NFKBIA/CASP1/IL18/CD14/ITGAM	3.30191729873663
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/454	137/9376	2.11042155696325	PMAIP1/CTSS/CTSD/CTSB/CFLAR/BAD/CTSL/CTSZ/NFKBIA/BCL2A1/GADD45G/LMNA/BIRC3/HRAS	2.95337190706992
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	14/454	138/9376	2.09512864713018	FN1/ARPC2/MAP2K3/CD4/NFKBIA/VAV3/FCGR2A/PIP5K1B/LCP2/BAIAP2/CASP1/IL18/WAS/BCAR1	2.92346675232506
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/454	71/9376	2.61785692126326	CXCL2/CXCL3/ATP6V0E1/NFKBIA/ATP6V1G1/ATP6V1E1/ATP6V1B2/ATP6V1C1/ATP6V0D1	3.08669381690431
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	23/454	275/9376	1.72725670804966	COX4I1/MT-ND2/MT-ND4L/C1QB/C1QA/SOD1/MT-ND3/MT-ND1/NCF2/SLC25A5/MT-ND5/MT-ND4/BAD/MT-ATP6/PSMD7/MT-CYB/CYBB/PSMB1/C1QC/UQCRB/NCF4/NDUFA13/NDUFAB1	2.7611625901365
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/454	73/9376	2.54613481383139	CDKN1A/BAD/CDKN2A/GADD45G/CDK6/STAT5B/EML4/RXRA/HRAS	2.99143612468804
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/454	142/9376	2.03611093876032	SKP1/UBE2A/BIRC7/UBE2I/NEDD4L/NEDD4/UBE2D3/BIRC3/UBE2Q1/UBE2E2/STUB1/UBE2E1/UBE2J1/ANAPC13	2.80632490880441
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	20/454	235/9376	1.75761552160465	COX4I1/MT-ND2/MT-ND4L/MT-ND3/MT-ND1/MT-ND5/MT-ND4/MT-ATP6/MGLL/MAP2K3/MT-CYB/PRKAB2/UQCRB/PRKAG2/NDUFA13/NDUFAB1/PRKG1/CPT2/ADCY7/HRAS	2.65319026732187
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	22/454	268/9376	1.69531198632389	COX4I1/MT-ND2/MT-ND4L/SOD1/MT-ND3/MT-ND1/SLC25A5/MT-ND5/MT-ND4/MT-ATP6/PSMD7/MT-CYB/TXN/NFE2L2/PINK1/PSMB1/UQCRB/NDUFA13/CAMK2G/UBE2J1/NDUFAB1/DUSP1	2.60506196091265
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/454	77/9376	2.41386807025574	CDKN1A/BAD/CDKN2A/NFKBIA/TGFBR1/GADD45G/CDK6/STAT5B/HRAS	2.81007933178331
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/454	52/9376	2.78007455099966	APOE/APOC1/LIPA/LPL/CYP27A1/CD36/ABCA1	2.90349569117964
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/454	78/9376	2.382921043714	C1QB/C1QA/ITGB2/LY96/C1QC/CFL1/CASP1/CD14/ITGAM	2.76651080575499
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/454	93/9376	2.22064326654351	FN1/CDKN1A/LAMC2/NFKBIA/BIRC7/CDKN2B/GADD45G/CDK6/BIRC3/RXRA	2.66850802986936
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/454	94/9376	2.19701940200581	CXCL2/MMP9/CXCL3/S100A9/CEBPB/NFKBIA/CCL20/JUND/S100A8/CXCL10	2.63103599515971
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/454	43/9376	2.88167195984018	ECI1/ACADVL/ACADL/HADHB/ACADS/CPT2	2.78965157246482
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	15/454	170/9376	1.8222337393107	ARPC2/MYL12B/MYL12A/MYL6/PRKAB2/AMOT/SYMPK/NEDD4L/NEDD4/SYNPO/HCLS1/AMOTL2/PRKAG2/PPP2R2B/WAS	2.44043207361297
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/454	69/9376	2.39443273957735	FCER1G/ALOX5AP/MAP2K3/ALOX5/VAV3/LCP2/SYK/HRAS	2.62240469953375
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/454	44/9376	2.81617941529836	RAB5C/STX4/DYNLL2/AQP3/RAB11A/VAMP2	2.72383111986812
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/454	83/9376	2.2393715832493	PRDX5/SOD1/PMVK/ECH1/SCP2/CROT/EPHX2/PRDX1/CAT	2.55826227754513
Organismal Systems	Immune system	hsa04611	Platelet activation	12/454	126/9376	1.96685546465282	VAMP8/FCER1G/MYL12B/MYL12A/FCGR2A/LCP2/SNAP23/FERMT3/TBXAS1/SYK/PRKG1/ADCY7	2.46466794949576
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/454	187/9376	1.76701453508917	GABARAPL1/GABARAPL2/MAP1LC3B/CXCL2/CXCL3/CTSB/GBP2/GABARAP/NFKBIA/TXN/CYBB/GBP1/CASP1/BIRC3/IL18/GBP3	2.38986146553196
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	27/454	368/9376	1.51522696801379	COX4I1/MT-ND2/MAP1LC3B/MT-ND4L/SOD1/MT-ND3/MT-ND1/MT-ND5/MT-ND4/BAD/MT-ATP6/SQSTM1/MAP2K3/PSMD7/ANXA11/MT-CYB/PINK1/ACTR1A/PSMB1/UQCRB/C9orf72/CASP1/GPX1/OPTN/NDUFA13/CAT/NDUFAB1	2.27452525083857
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	20/454	253/9376	1.63256777698456	CAST/MAP1LC3B/ARPC2/SKP1/MYL12B/MYL12A/SQSTM1/CD44/FOXO4/NFKBIA/RRAGD/HCLS1/TNIP1/UBE2D3/CASP1/IL18/CD14/CALCOCO2/CYTH3/BCAR1	2.3008109918883
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	17/454	205/9376	1.71260341678307	PMAIP1/GSN/HLA-B/CDKN1A/BAD/CDKN2A/HLA-A/NFKBIA/SCIN/CDKN2B/HLA-F/SP100/CDK6/STAT5B/SYK/ATP6V0D1/HRAS	2.3270136957282
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/454	100/9376	2.06519823788546	CXCL2/CXCL3/CCL18/CXCL9/CXCR4/CCL3/CCL20/TNFRSF14/IL18/CXCL10	2.41564173625162
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/454	103/9376	2.00504683289851	FN1/ITGB2/CXCL2/CXCL3/LAMC2/HSPB1/RAB5C/PRDX1/CD14/ITGAM	2.31354119517235
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/454	75/9376	2.20287812041116	PMAIP1/CDKN1A/SERPINE1/CDKN2A/GADD45G/CDK6/STEAP3/PPM1D	2.35922787067401
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	16/454	196/9376	1.68587611255956	MAP1LC3B/HLA-B/CDKN1A/CXCL2/CXCL3/HLA-A/NFKBIA/CD86/GNG12/HLA-F/CDK6/RCAN1/CLEC2B/ICAM1/SYK/HRAS	2.18894489122067
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/454	119/9376	1.90900677451597	CXCL2/MMP9/CXCL3/CFLAR/MAP2K3/CEBPB/NFKBIA/CCL20/BIRC3/ICAM1/CXCL10	2.25106442133156
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/454	78/9376	2.11815203885688	FN1/ARPC2/CLTB/HCLS1/CLTCL1/CLTA/ELMO3/BCAR1	2.23684476567579
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/454	201/9376	1.64393889582922	CDKN1A/HPGD/NUPR1/MMP9/SPI1/CEBPB/CD86/BCL2A1/GADD45G/BIRC3/FCGR1A/CD14/PER2/RXRA/CDK9/ITGAM	2.08171899963854
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/454	51/9376	2.4296449857476	ATP6V0E1/ATP6V1G1/ATP6V1E1/ATP6V1B2/ATP6V1C1/ATP6V0D1	2.30925199968726
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/454	204/9376	1.61976332383174	FN1/TIMP3/CDKN1A/MRAS/MMP9/IGF2/CTSL/CD44/PPP1R12B/VAV3/PTPN6/HCLS1/PLAUR/CAMK2G/NUDT16L1/HRAS	2.01879113035548
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	18/454	238/9376	1.56191463369489	RPS4Y1/RPL34/C1QB/C1QA/FAU/C5AR1/NFKBIA/CYBB/C1QC/FCGR2A/RPLP2/RPL23/C3AR1/CASP1/SYK/NRP1/CXCL10/RPS15A	1.98068630711735
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/454	142/9376	1.74523794750884	GSTA3/HMOX1/NCF2/MMP9/CTSL/SQSTM1/GSTT1/TXN/ASS1/NFE2L2/ICAM1/DUSP1	2.01849023771781
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/454	41/9376	2.51853443644569	CDKN1A/MMP9/CDKN2A/DAPK1/HRAS	2.19807176402767
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/454	298/9376	1.45534104012063	CSH1/CSH2/CXCL2/CXCL16/CXCL3/CCL18/TNFRSF12A/CD4/TGFBR1/CXCL9/CXCR4/IL27/CCL3/CCL20/TNFSF13B/OSM/TNFRSF14/IL18/CXCR6/IL1RN/CXCL10	1.80190667158556
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/454	57/9376	2.1738928819847	SCP2/ACADVL/ACADL/HADHB/ACADS/CPT2	2.00522770510773
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/454	87/9376	1.89903286242341	PMAIP1/CDKN1A/BAD/TGFBR1/EREG/GADD45G/RALGDS/HRAS	1.90034812575522
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/454	103/9376	1.80454214960866	C1QB/C1QA/SERPINE1/CFLAR/NFKBIA/TGFBR1/CCL3/C1QC/PPP2R2B	1.85199469859939
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/454	20/9376	3.09779735682819	CYB5R1/CMAS/NPL	2.11843859618375
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/454	75/9376	1.92751835535977	GSTA3/PMAIP1/CDKN1A/BAD/GSTT1/CDKN2A/BIRC3	1.8191594953764
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	21/454	308/9376	1.40808970764918	COX4I1/MT-ND2/CLTB/MT-ND4L/SOD1/MT-ND3/MT-ND1/SLC25A5/MT-ND5/MT-ND4/MT-ATP6/PSMD7/MT-CYB/ACTR1A/PSMB1/UQCRB/CLTCL1/GPX1/NDUFA13/NDUFAB1/CLTA	1.6426978901945
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/454	91/9376	1.81555889044876	DAPP1/NFKBIA/LILRB4/VAV3/PTPN6/LILRB2/SYK/HRAS	1.76346775761563
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/454	77/9376	1.87745294353224	CDKN1A/BAD/CDKN2A/TGFBR1/GADD45G/CDK6/RALGDS	1.74394799140374
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/454	62/9376	1.99857893988916	SOD1/PRKAB2/PRKAG2/CAT/ADCY7/HRAS	1.77947784643914
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/454	21/9376	2.95028319697923	PPCS/DPYD/PANK1	2.01821711906304
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/454	34/9376	2.4296449857476	SKP1/PRKAB2/PRKAG2/PER2	1.88378002561154
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/454	109/9376	1.70520955421735	SPP1/MAP2K3/LY96/NFKBIA/CD86/CXCL9/CCL3/CD14/CXCL10	1.67049165385223
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	30/454	480/9376	1.29074889867841	COX4I1/MT-ND2/MAP1LC3B/MT-ND4L/SOD1/MT-ND3/MT-ND1/SLC25A5/MT-ND5/MT-ND4/BAD/MT-ATP6/SQSTM1/MAP2K3/PSMD7/MT-CYB/CYBB/PINK1/ACTR1A/PSMB1/UQCRB/C9orf72/GPX1/OPTN/NDUFA13/CAT/CAMK2G/UBE2J1/NDUFAB1/HRAS	1.47510781914645
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/454	195/9376	1.48270642719982	ITGB2/NCF2/FCGR3A/SLC25A5/FPR3/C5AR1/CYBB/FCGR2A/AQP9/CASP1/NCF4/FCGR1A/SYK/ITGAM	1.53651869457914
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/454	37/9376	2.23264674365996	CDKN1A/GADD45G/RXRA/HRAS	1.69461779376858
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/454	83/9376	1.74173345363834	NFKBIA/SAMHD1/TREX1/CASP1/IL18/PCBP1/CXCL10	1.53105714225058
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/454	149/9376	1.52464299441209	MT-ND2/MT-ND4L/MT-ND3/MT-ND1/MT-ND5/MT-ND4/MGLL/GNG12/NDUFA13/NDUFAB1/ADCY7	1.45616036926206
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/454	203/9376	1.42427464681756	SPP1/FN1/MYL12B/MYL12A/BAD/PPP1R12B/LAMC2/VAV3/PIP5K1B/ITGB6/BIRC3/PARVG/BCAR1/HRAS	1.37854789041471
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/454	101/9376	1.63580058446373	FN1/SERPINE1/TGFBR1/CYBB/PIM1/STAT5B/ICAM1/HRAS	1.44912919380513
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/454	170/9376	1.45778699144856	GSTA3/HMOX1/CDKN1A/IGF2/BAD/GSTT1/CDKN2A/TGFBR1/NFE2L2/GADD45G/CDK6/HRAS	1.3587353612495
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	21/454	333/9376	1.30237726713498	SPP1/FN1/HLA-B/CDKN1A/BAD/ATP6V0E1/HLA-A/LAMC2/MAML2/ATP6V1G1/ATP6V1E1/HLA-F/ITGB6/HES2/ATP6V1B2/CDK6/PTGER4/PPP2R2B/ATP6V1C1/ATP6V0D1/HRAS	1.26735255321894
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/454	105/9376	1.57348437172226	FCER1G/MRAS/LSP1/PLK3/NFKBIA/CASP1/SYK/HRAS	1.33301612031748
NA	NA	hsa04517	IgSF CAM signaling	19/454	299/9376	1.3123333284222	ARPC2/ITGB2/MYL12B/MYL12A/CD84/RASA1/MYL6/CD86/CD48/VAV3/DYNLL2/PTPN6/LCP2/BAIAP2/SORBS1/ICAM1/NRP1/ITGAM/BCAR1	1.23812704714405
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	15/454	227/9376	1.36466843913136	HLA-B/CDKN1A/CDKN2A/HLA-A/NFKBIA/CXCR4/GNG12/CCL3/HLA-F/CDK6/PTGER4/TAPBPL/ADCY7/BCAR1/HRAS	1.25460423195191
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/454	140/9376	1.47514159848962	SPP1/MAP1LC3B/MRAS/SERPINE1/TGFBR1/PRKAB2/GNG12/PRKAG2/ADCY7/HRAS	1.27769608866028
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/454	73/9376	1.69742320922093	CDKN1A/BAD/CDKN2A/GADD45G/CDK6/HRAS	1.34936291686584
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/454	214/9376	1.35106426777554	HLA-B/SKP1/BAD/HLA-A/MAP2K3/CD4/NFKBIA/SAMHD1/CXCR4/GNG12/HLA-F/CFL1/TAPBPL/HRAS	1.17187375020249
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/454	59/9376	1.75016799820802	GSTA3/GPX4/SMS/GSTT1/GPX1	1.30385394895775
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/454	59/9376	1.75016799820802	ADRB1/MGLL/FABP4/PRKG1/ADCY7	1.30385394895775
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/454	76/9376	1.63041966148852	CDKN1A/CDKN2A/GADD45G/CDK6/CAMK2G/HRAS	1.24473679154591
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/454	110/9376	1.50196235482579	FBN1/SKP1/HAMP/TGFBR1/CDKN2B/SMAD7/E2F4/TGIF1	1.19454852901853
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/454	93/9376	1.55445028658046	MYL12B/MYL12A/TGFBR1/PTPN6/BAIAP2/WAS/SORBS1	1.21211092745628
NA	NA	hsa04382	Cornified envelope formation	14/454	217/9376	1.3323859599261	KRT8/KRT18/S100A11/S100A6/S100A9/LAMC2/DST/KRT7/COL17A1/KRT80/EPHX2/PPP2R2B/S100A8/TMEM79	1.11745736793863
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/454	46/9376	1.79582455468301	PSMB10/PSMD7/PSMB1/PSMB9	1.22050028187188
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/454	31/9376	1.99857893988916	GLUL/ACSS1/CAT	1.25619208229826
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/454	63/9376	1.63904622054402	GPX4/HPGD/ALOX5/EPHX2/TBXAS1	1.14799553547423
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/454	168/9376	1.35221313194881	FTL/SLC25A5/GLUL/CFLAR/SQSTM1/CYBB/CHMP5/STAT5B/CASP1/BIRC3/CAMK2G	1.03910631680463
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/454	168/9376	1.35221313194881	CSH1/CSH2/CDKN1A/IL27/OSM/PIM1/PTPN6/STAT5B/SOCS2/CISH/HRAS	1.03910631680463
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/454	47/9376	1.75761552160465	LDHB/ACSS1/HAGH/LDHD	1.17452617918733
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/454	17/9376	2.4296449857476	SCP2/CYP27A1	1.33082330533067
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/454	32/9376	1.93612334801762	LDHB/ACSS1/ACADS	1.19653141808378
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/454	32/9376	1.93612334801762	GABARAPL1/GABARAPL2/GABARAP	1.19653141808378
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/454	32/9376	1.93612334801762	PMAIP1/BIRC7/BIRC3	1.19653141808378
NA	NA	hsa04518	Integrin signaling	10/454	154/9376	1.34103781680874	SPP1/FN1/FBN1/ITGB2/LAMC2/ITGB6/FERMT3/PARVG/ICAM1/ITGAM	0.962571050642046
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/454	154/9376	1.34103781680874	CDKN1A/RGS2/PPP1R12B/MYL6/PRKAB2/RCAN1/PRKAG2/CAMK2G/ADCY7/HRAS	0.962571050642046
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/454	18/9376	2.29466470876162	TCN2/PRDX1	1.24017935378363
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/454	50/9376	1.65215859030837	ITGB2/CD36/IL18/ICAM1	1.04297277246881
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	10/454	158/9376	1.30708749233257	LAMTOR5/ATP6V1G1/ATP6V1E1/LPIN2/RRAGD/WDR59/ATP6V1B2/FNIP2/ATP6V1C1/HRAS	0.878121831944288
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/454	86/9376	1.44083597992009	CDKN1A/BAD/EREG/STAT5B/CAMK2G/HRAS	0.926404929059315
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/454	122/9376	1.35422835271178	CD4/NFKBIA/VAV3/PTPRC/PTPN6/LCP2/PPP2R2B/HRAS	0.888343527571219
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/454	122/9376	1.35422835271178	CSH1/CSH2/MAP2K3/STAT5B/SOCS2/ADCY7/BCAR1/HRAS	0.888343527571219
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/454	52/9376	1.58861402914266	HSD17B1/ALOX5/HSD3B1/ADCY7	0.960093663731016
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/454	70/9376	1.47514159848962	NFKBIA/CD36/PRKAB2/PRKAG2/RXRA	0.900063200028474
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/454	53/9376	1.5586401795362	CLTB/CLTCL1/CLTA/RAB11A	0.91997222663038
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/454	71/9376	1.45436495625737	GALT/STAT5B/SOCS2/CISH/HRAS	0.866878574158782
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/454	89/9376	1.39226847497896	SPP1/FN1/CD44/LAMC2/CD36/ITGB6	0.838731864577596
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/454	89/9376	1.39226847497896	GABARAPL1/GABARAPL2/GLUL/GABARAP/GNG12/ADCY7	0.838731864577596
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/454	37/9376	1.67448505774497	GLUL/ASS1/IL4I1	0.92726840545726
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/454	90/9376	1.37679882525697	MAP2K3/CD4/NFKBIA/PTPN6/EML4/HRAS	0.810212446158422
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/454	73/9376	1.41451934101744	TSG101/CD4/SAMHD1/CXCR4/CDK9	0.802005180925107
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/454	110/9376	1.31421706047257	HMOX1/CDKN1A/LDHB/SERPINE1/CYBB/EPAS1/CAMK2G	0.747760312643961
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/454	300/9376	1.17027900146843	MRAS/DUSP9/IGF2/DUSP2/RASA1/MAP2K3/HSPB1/TGFBR1/EREG/GNG12/GADD45G/MAPKAPK3/ARRB2/JUND/CD14/DUSP1/HRAS	0.676171612087826
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/454	75/9376	1.37679882525697	TALDO1/GLUL/SDS/ASS1/SDSL	0.73902274478118
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/454	23/9376	1.79582455468301	GLUL/ASS1	0.861962239659089
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/454	41/9376	1.51112066186741	SDS/SDSL/BPGM	0.73984485823814
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/454	59/9376	1.40013439856642	CDKN1A/BAD/GADD45G/HRAS	0.695466638047632
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/454	116/9376	1.24624031596537	TALDO1/SDS/FBP1/ACSS1/SDSL/ACADS/CAT	0.601956510845504
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/454	60/9376	1.37679882525697	BAD/HSPB1/MAPKAPK3/HRAS	0.660469672687249
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/454	42/9376	1.47514159848962	AOC1/IL4I1/CAT	0.696139467206149
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/454	156/9376	1.191460521857	CDKN1A/CFLAR/BAD/NFKBIA/CDK6/PPP2R2B/RXRA/CXCL10/HRAS	0.543949437699523
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/454	99/9376	1.25163529568816	CDKN1A/MMP9/BAD/CDKN2A/ADCY7/HRAS	0.567763973502801
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/454	138/9376	1.19721636978867	RHOQ/BAD/FBP1/PRKAB2/PRKAG2/SOCS2/SORBS1/HRAS	0.526472850109726
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/454	158/9376	1.17637874309931	CDKN1A/TFDP2/SKP1/CDKN2A/CDKN2B/GADD45G/CDK6/E2F4/ANAPC13	0.504357972478624
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/454	65/9376	1.27089122331413	LPL/MGLL/LPIN2/GK	0.494351555016314
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/454	184/9376	1.12239034667688	MYL12B/MYL12A/RASA1/CXCR4/PLXNC1/CFL1/CAMK2G/NRP1/HRAS/RHOD	0.378210449568624
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/454	67/9376	1.23295417187192	LDHB/FBP1/ACSS1/BPGM	0.431657045460376
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/454	48/9376	1.29074889867841	IL4I1/HADHB/ACADS	0.455540383952108
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/454	29/9376	1.42427464681756	RASSF6/RASSF4	0.516169588545837
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/454	107/9376	1.15805508666475	LDHB/FBP1/PPP4C/PRKAB2/PRKAG2/CAMK2G	0.370908153374012
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	20/454	388/9376	1.06453517416776	APOE/COX4I1/MT-ND2/MT-ND4L/MT-ND3/MT-ND1/SLC25A5/MT-ND5/MT-ND4/LPL/BAD/MT-ATP6/PSMD7/MT-CYB/CYBB/PSMB1/UQCRB/NDUFA13/NDUFAB1/HRAS	0.292862167676398
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/454	149/9376	1.10883126866334	FCER1G/MRAS/PIP5K1B/SYK/RALGDS/ADCY7/CYTH3/HRAS	0.302064036024437
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/454	50/9376	1.23911894273128	AOC1/SMS/CKMT1B	0.38241395629294
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/454	70/9376	1.18011327879169	CDKN1A/BAD/EPAS1/HRAS	0.341189520328674
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/454	130/9376	1.11202982039986	MMP9/NFKBIA/TGFBR1/GNG12/ARRB2/ADCY7/HRAS	0.290142151066749
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/454	90/9376	1.14733235438081	PRKAB2/PRKAG2/CAT/ADCY7/HRAS	0.316801696926065
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/454	31/9376	1.3323859599261	TALDO1/FBP1	0.418134805819784
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/454	31/9376	1.3323859599261	ACADS/DPYD	0.418134805819784
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/454	212/9376	1.07156512343114	MRAS/ITGB2/MAP2K3/SIPA1/VAV3/LCP2/RALGDS/ADCY7/ITGAM/BCAR1/HRAS	0.237743838335927
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/454	91/9376	1.13472430653047	GNG12/PDE7A/ARRB2/PDE4B/ADCY7	0.291311851928788
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/454	194/9376	1.06453517416776	DYNLRB1/MYL12B/MYL12A/KIFC3/MYL6/DYNLT1/ACTR1A/DYNLL2/TNNC1/DYNLRB2	0.204885470968552
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/454	174/9376	1.06820598511317	SKP1/NFE2L2/SVIP/DNAJB2/AMFR/UBE2D3/HSPA4L/STUB1/UBE2J1	0.204851170948289
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/454	93/9376	1.11032163327175	LYZ/ADRB1/PRKG1/ADCY7/VAMP2	0.241179525847558
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/454	217/9376	1.04687468279908	GSTA3/ADRB1/BAD/GSTT1/PAQR7/ARRB2/STAT5B/EPHX2/RXRA/ADCY7/HRAS	0.157589266632278
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/454	115/9376	1.07749473280981	CDKN1A/ARRB2/JUND/PDE4B/RXRA/ADCY7	0.188614301004823
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/454	157/9376	1.05233031229832	ITGB2/SERPINE1/RASSF6/TGFBR1/AMOT/SMAD7/BIRC3/PPP2R2B	0.149157020825816
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/454	157/9376	1.05233031229832	COX4I1/MT-CYB/PRKAB2/UQCRB/PRKAG2/NDUFA13/RXRA/NDUFAB1	0.149157020825816
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/454	97/9376	1.06453517416776	GNG12/CAMK2G/PER2/PRKG1/ADCY7	0.144116670922014
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/454	35/9376	1.18011327879169	FBP1/KHK	0.240805012915151
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/454	15/9376	1.37679882525697	HEXB	0.329440131181647
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/454	36/9376	1.14733235438081	GALNT18/GALNT7	0.199782938390219
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/454	99/9376	1.04302941307347	PIP5K1B/WAS/GPCPD1/RALGDS/HRAS	0.0970871374672339
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/454	99/9376	1.04302941307347	PRKAB2/ITGB6/LMNA/PRKAG2/TNNC1	0.0970871374672339
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/454	163/9376	1.01359422718305	CDKN1A/MMP9/BAD/MAP2K3/NFKBIA/TGFBR1/STAT5B/HRAS	0.0394939202855244
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/454	37/9376	1.11632337182998	CMAS/GALT	0.159919017145939
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/454	37/9376	1.11632337182998	IL18/ICAM1	0.159919017145939
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/454	16/9376	1.29074889867841	IL4I1	0.262556394856799
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/454	16/9376	1.29074889867841	HEXB	0.262556394856799
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/454	38/9376	1.08694644099235	HEXB/GALT	0.121143224237979
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/454	38/9376	1.08694644099235	CD4/PTPRC	0.121143224237979
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/454	82/9376	1.00741377457827	GSTA3/GSTT1/UPP1/DPYD	0.0152099373125404
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/454	125/9376	0.991295154185022	FCER1G/CTSD/ORMDL1/PPP2R2B/ASAH1/HRAS	-0.022100607121065
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/454	17/9376	1.2148224928738	CDO1	0.199973268102071
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/454	17/9376	1.2148224928738	GLUL	0.199973268102071
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/454	61/9376	1.01567126453383	FTL/HMOX1/SLC40A1	0.0276987381507901
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/454	83/9376	0.99527625922191	SKP1/UBE2D3/FBRS/L3MBTL3	-0.00975056069125571
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	11/454	233/9376	0.974986292563952	FN1/FBN1/VIM/FMNL2/CSRP2/ITGB6/LMNA/TNNC1/FMNL1/FBLN1/CSRP1	-0.0872155897390441
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/454	105/9376	0.983427732326411	ADRB1/ITGB6/LMNA/TNNC1/ADCY7	-0.0385208404071552
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/454	106/9376	0.974150112210124	CDKN1A/MMP9/BAD/NFKBIA/HRAS	-0.0603745883964749
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	17/454	362/9376	0.969844476355051	SPP1/CSH1/FN1/CSH2/CDKN1A/IGF2/BAD/LAMC2/EREG/GNG12/OSM/ITGB6/CDK6/PPP2R2B/SYK/RXRA/HRAS	-0.131991157637448
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/454	18/9376	1.14733235438081	HEXB	0.141131941583694
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/454	19/9376	1.08694644099235	HEXB	0.0855741808312083
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/454	87/9376	0.949516431211707	COX4I1/MT-CYB/UQCRB/TNNC1	-0.106710621311065
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/454	65/9376	0.953168417485598	SPP1/ARRB2/HRAS	-0.0854633286255373
NA	NA	hsa04081	Hormone signaling	10/454	219/9376	0.943012894011627	CSH1/CSH2/SLC40A1/ADRB1/IGF2/HAMP/GNG12/STAT5B/PRKG1/ADCY7	-0.192488375802885
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/454	43/9376	0.960557319946727	CD36/ABCA1	-0.058475301105186
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/454	155/9376	0.932670171948273	CDKN1A/CDKN2A/CDKN2B/CDK6/HSD3B1/CAMK2G/ADCY7	-0.190663165260784
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/454	20/9376	1.03259911894273	LIPA	0.0329198773871477
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/454	89/9376	0.928178983319309	ADRB1/PRKG1/ADCY7/HRAS	-0.153564660631179
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/454	200/9376	0.929339207048458	ARPC2/NFKBIA/FCGR2A/PTPN6/HCLS1/BAIAP2/CASP1/IL18/CYTH3	-0.227850117728873
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/454	21/9376	0.983427732326411	DSE	-0.0171495269878433
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/454	69/9376	0.897912277341505	ADRB1/CTSB/PTGER4	-0.191988696238929
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/454	46/9376	0.897912277341505	FTL/HMOX1	-0.156564777433866
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/454	22/9376	0.938726471766119	AOC1	-0.0649034826609849
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/454	93/9376	0.888257306617403	MAP2K3/CAMK2G/ADCY7/HRAS	-0.244286174956802
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/454	139/9376	0.891452476785092	KRT18/CTSD/MMP9/FKBP4/ADCY7/HRAS	-0.290833414337062
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/454	23/9376	0.897912277341505	PMVK	-0.110571810767339
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/454	49/9376	0.842938056279781	GALNT18/GALNT7	-0.248645426038584
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/454	166/9376	0.870866726819171	RGS2/ADRB1/SLC25A5/BAD/CNGB1/PRKG1/ADCY7	-0.378656000543364
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/454	122/9376	0.846392720444862	FBP1/CD36/PRKAB2/PRKAG2/PPP2R2B	-0.385220526634859
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/454	99/9376	0.834423530458773	MAP2K3/PTGER4/CAMK2G/ADCY7	-0.373589698568333
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/454	26/9376	0.794307014571332	TCN2	-0.236909679552516
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/454	78/9376	0.794307014571332	BTG3/LSM1/CNOT6L	-0.411485434720235
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/454	27/9376	0.764888236253875	ACADS	-0.27596634192906
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/454	27/9376	0.764888236253875	SCP2	-0.27596634192906
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/454	150/9376	0.826079295154185	CDKN1A/TGFBR1/CDKN2B/GADD45G/RXRA/HRAS	-0.484364880322107
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/454	103/9376	0.802018733159403	SYMPK/PPP2R2B/SSU72/SAP18	-0.455737784265407
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/454	104/9376	0.794307014571332	LPIN2/LPCAT3/PCYT2/GPCPD1	-0.47580816997799
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/454	28/9376	0.737570799244808	HADHB	-0.31369982523831
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/454	28/9376	0.737570799244808	MOCS2	-0.31369982523831
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/454	55/9376	0.750981177412895	HEXB/ASAH1	-0.417796426733186
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/454	29/9376	0.71213732340878	CNGB1	-0.35021173300908
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/454	109/9376	0.757870912985491	NFKBIA/CD36/PRKAB2/PRKAG2	-0.573552381123772
NA	NA	hsa04981	Folate transport and metabolism	1/454	31/9376	0.666192979963052	SLCO2B1	-0.419922470658689
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/454	59/9376	0.700067199283208	UPP1/DPYD	-0.521307983772595
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/454	86/9376	0.720417989960045	CAMK2G/ADCY7/VAMP2	-0.58753405796023
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/454	136/9376	0.759264058046126	BAD/NFKBIA/RAB9A/CDK6/STAT5B	-0.637906252826266
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/454	60/9376	0.688399412628487	PRKG1/HRAS	-0.546187313110811
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/454	32/9376	0.645374449339207	GALT	-0.453274254850559
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/454	138/9376	0.748260231117921	SKP1/CPEB2/CAMK2G/ADCY7/ANAPC13	-0.672024100997943
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/454	62/9376	0.666192979963052	MAML2/TLE6	-0.59484751121183
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/454	115/9376	0.718329821873204	GNG12/CAMK2G/ADCY7/HRAS	-0.685556577008631
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/454	115/9376	0.718329821873204	GNG12/ALOX5/DUSP1/HRAS	-0.685556577008631
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/454	63/9376	0.655618488217607	CDKN1A/GADD45G	-0.618653902200521
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/454	90/9376	0.688399412628487	AQP9/RXRA/ADCY7	-0.670019801538649
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/454	116/9376	0.71213732340878	GLUL/GNG12/HOMER3/ADCY7	-0.703706099970531
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/454	238/9376	0.780957316847444	MRAS/IGF2/BAD/RASA1/FOXO4/RAB5C/GNG12/RALGDS/HRAS	-0.772100986837957
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/454	65/9376	0.635445611657065	HSD3B1/ADCY7	-0.665278212267388
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/454	36/9376	0.573666177190406	AGL	-0.578109433016214
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/454	66/9376	0.62581764784408	HSD17B1/HSD3B1	-0.688117944137042
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/454	120/9376	0.688399412628487	BAD/NFKBIA/CAMK2G/HRAS	-0.774925001616319
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/454	37/9376	0.55816168591499	IL4I1	-0.607430371165383
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/454	67/9376	0.616477085935959	CAMK2G/HRAS	-0.710656377694149
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/454	122/9376	0.677114176355889	BAD/RCAN1/RXRA/HRAS	-0.809741878036884
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/454	38/9376	0.543473220496174	NEDD4L	-0.63608268939888
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/454	39/9376	0.529538009714221	AHCYL2	-0.664103273253432
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/454	70/9376	0.590056639395847	GSTA3/GSTT1	-0.776557839070924
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/454	98/9376	0.632203542209835	HSD3B1/CAMK2G/ADCY7	-0.825611723493864
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/454	226/9376	0.731043624030252	ADRB1/BAD/NFKBIA/CNGB1/VAV3/CAMK2G/PDE4B/ADCY7	-0.923225883823885
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/454	323/9376	0.767256311288717	TIMP3/HMOX1/CDKN1A/VIM/MMP9/CD44/CDKN2A/UBE2I/PIM1/CDK6/ZEB2/HRAS	-0.960208108915105
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/454	71/9376	0.581745982502947	LDHB/HRAS	-0.797982857900362
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/454	178/9376	0.696134237489482	SKP1/CBY1/CAMK2G/MMP7/CTNNBIP1/TLE6	-0.923267446963573
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/454	72/9376	0.573666177190406	NFKBIA/CXCL10	-0.819150387257675
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/454	154/9376	0.670518908404371	ADRB1/PPP2R2B/TNNC1/CAMK2G/ADCY7	-0.929952471170532
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/454	101/9376	0.6134252191739	CAMK2G/ADCY7/HRAS	-0.881088841647451
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/454	128/9376	0.645374449339207	PDE7A/LACC1/PDE4B/ADCY7	-0.911241630846869
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/454	73/9376	0.565807736406976	GSTA3/GSTT1	-0.840068026897094
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/454	75/9376	0.55071953010279	GPX1/ADCY7	-0.881182381111652
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/454	44/9376	0.46936323588306	HEXB	-0.795827173941623
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/454	76/9376	0.543473220496174	CAMK2G/ADCY7	-0.90139269678334
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/454	133/9376	0.621112251995628	GNG12/ARRB2/PPP2R2B/CAMK2G	-0.992687060521104
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/454	45/9376	0.458932941752325	ABCA1	-0.820683517056047
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/454	134/9376	0.616477085935959	PPP1R12B/MYL6/PRKG1/ADCY7	-1.00865626135478
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/454	78/9376	0.529538009714221	ISYNA1/PIP5K1B	-0.94115147479944
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/454	79/9376	0.522834996933028	GSTA3/GSTT1	-0.960711897034241
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/454	47/9376	0.439403880401162	SOCS2	-0.869088343154699
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/454	80/9376	0.516299559471366	BAD/HRAS	-0.980067243339413
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/454	110/9376	0.563235883059672	CPEB2/ADCY7/ANAPC13	-1.03939255285433
NA	NA	hsa03272	Virion - Hepatitis viruses	1/454	48/9376	0.430249632892805	TSG101	-0.892675095825344
Genetic Information Processing	Translation	hsa03010	Ribosome	7/454	222/9376	0.651188633567488	RPS4Y1/RPL34/MRPL46/FAU/RPLP2/RPL23/RPS15A	-1.18643545592123
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/454	51/9376	0.404940830957934	PLA2G7	-0.961176788462665
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/454	85/9376	0.485928997149521	UPP1/LACC1	-1.07394933976422
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/454	86/9376	0.480278659973363	ITGB6/LMNA	-1.09218038696674
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/454	117/9376	0.529538009714221	SRCAP/BCL7B/SMARCA1	-1.15509548293036
NA	NA	hsa04519	Cadherin signaling	14/454	404/9376	0.715662755702883	KRT8/KRT18/ARPC2/MRAS/VIM/MAP2K3/NFKBIA/KRT7/VAV3/AMOTL2/KRT80/CDH26/TMC4/HRAS	-1.31783869494592
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/454	54/9376	0.382444118126937	RMI2	-1.02659949969012
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/454	148/9376	0.55816168591499	CDKN1A/GADD45G/CDK6/HRAS	-1.22214544378313
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/454	56/9376	0.368785399622404	ARRB2	-1.06867475012354
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/454	154/9376	0.536415126723497	PNPO/PPCS/PANK1/MOCS2	-1.30845717553305
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/454	63/9376	0.327809244108804	SMYD2	-1.2075370480921
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/454	63/9376	0.327809244108804	XPC	-1.2075370480921
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/454	102/9376	0.404940830957934	ADCY7/RAB11A	-1.3630417131207
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/454	103/9376	0.401009366579701	SLC7A7/COL17A1	-1.37883077741132
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/454	68/9376	0.30370562321845	DHRS4L2	-1.29987506246218
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/454	254/9376	0.569149120677096	ADRB1/SLC25A5/CXCR4/TNNC1/CAMK2G/TFEB/ADCY7	-1.57029505539179
NA	NA	hsa04082	Neuroactive ligand signaling	5/454	199/9376	0.518894029619463	ADRB1/GNG12/P2RY6/TAC3/ADCY7	-1.54738853212988
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/454	69/9376	0.299304092447168	CAMK2G	-1.317746054548
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/454	108/9376	0.382444118126937	UBE2I/SAP18	-1.45605433892402
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/454	144/9376	0.430249632892805	DUSP9/ISL1/HRAS	-1.55417678305308
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/454	144/9376	0.430249632892805	SLC25A5/PSMD7/PSMB1	-1.55417678305308
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/454	370/9376	0.55816168591499	CSH1/CSH2/ADRB1/FPR3/C5AR1/NPB/C3AR1/P2RY6/PTGER4/TAC3	-1.95605345489811
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/454	98/9376	0.210734514069945	PIP5K1B	-1.77170504046752
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/454	191/9376	0.324376686578868	SLC29A3/GNG12/HRAS	-2.12796355490612
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/454	183/9376	0.112852362725982	SBDS	-2.7338537018059
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/454	243/9376	0.0849875818059861	PCBP1	-3.25991181017236
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/454	449/9376	0.229977532058515	RGS2/CNGB1/ARRB2/CAMK2G/PRKG1	-3.77186600091384