ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0023023 MHC protein complex binding 14/745 37/18639 0.378378378378378 9.46656992563033 6.11786884896794e-11 5.71408950493606e-08 GO:0023026 MHC class II protein complex binding 12/745 27/18639 0.444444444444444 11.1194630872483 1.52435299936191e-10 7.1187285070201e-08 GO:0042605 peptide antigen binding 12/745 45/18639 0.266666666666667 6.67167785234899 1.29953098231681e-07 4.04587312494632e-05 GO:0042277 peptide binding 29/745 249/18639 0.116465863453815 2.9138352065982 2.54397069489611e-07 5.94017157258241e-05 GO:0032395 MHC class II receptor activity 6/745 10/18639 0.6 15.0112751677852 7.31451963878867e-07 0.000136635226852572 GO:0140375 immune receptor activity 20/745 156/18639 0.128205128205128 3.20753742901394 4.23874736360264e-06 0.000659831672934144 GO:0043394 proteoglycan binding 9/745 37/18639 0.243243243243243 6.08565209504807 1.12731665375547e-05 0.0015041625065823 GO:0048306 calcium-dependent protein binding 13/745 80/18639 0.1625 4.06555369127517 1.59013548498071e-05 0.00173755777417956 GO:0015078 proton transmembrane transporter activity 21/745 185/18639 0.113513513513514 2.8399709776891 1.67430620638287e-05 0.00173755777417956 GO:0001540 amyloid-beta binding 13/745 83/18639 0.156626506024096 3.91860596749414 2.39066589622122e-05 0.00223288194707062 GO:0004857 enzyme inhibitor activity 35/745 416/18639 0.0841346153846154 2.1049464377904 2.9327697816453e-05 0.00236850402990698 GO:0008429 phosphatidylethanolamine binding 6/745 17/18639 0.352941176470588 8.83016186340308 3.38788601049757e-05 0.00236850402990698 GO:0016209 antioxidant activity 13/745 86/18639 0.151162790697674 3.78191041048853 3.52369443334643e-05 0.00236850402990698 GO:0019864 IgG binding 5/745 11/18639 0.454545454545455 11.3721781574131 3.8038073285444e-05 0.00236850402990698 GO:0042608 T cell receptor binding 5/745 11/18639 0.454545454545455 11.3721781574131 3.8038073285444e-05 0.00236850402990698 GO:0038024 cargo receptor activity 11/745 65/18639 0.169230769230769 4.2339494062984 4.81709990376141e-05 0.00281198206882072 GO:0035325 Toll-like receptor binding 5/745 13/18639 0.384615384615385 9.62261228704182 9.91077802183571e-05 0.00544509804258503 GO:0061650 ubiquitin-like protein conjugating enzyme activity 8/745 41/18639 0.195121951219512 4.88171550171878 0.00018578447577467 0.00964015002075232 GO:0031625 ubiquitin protein ligase binding 26/745 302/18639 0.0860927152317881 2.15393573047691 0.000210365839166936 0.00988957229952035 GO:0071813 lipoprotein particle binding 7/745 32/18639 0.21875 5.47286073825503 0.000222356550631614 0.00988957229952035 GO:0071814 protein-lipid complex binding 7/745 32/18639 0.21875 5.47286073825503 0.000222356550631614 0.00988957229952035 GO:0044389 ubiquitin-like protein ligase binding 27/745 322/18639 0.0838509316770186 2.09784901413148 0.000245659623350038 0.0100299254048977 GO:0022853 active monoatomic ion transmembrane transporter activity 14/745 118/18639 0.11864406779661 2.96833124786714 0.000261853663596012 0.0100299254048977 GO:0140311 protein sequestering activity 7/745 33/18639 0.212121212121212 5.30701647345943 0.000272579451331549 0.0100299254048977 GO:0042625 ATPase-coupled ion transmembrane transporter activity 6/745 24/18639 0.25 6.25469798657718 0.000289944310419955 0.0100299254048977 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 6/745 24/18639 0.25 6.25469798657718 0.000289944310419955 0.0100299254048977 GO:0046961 proton-transporting ATPase activity, rotational mechanism 6/745 24/18639 0.25 6.25469798657718 0.000289944310419955 0.0100299254048977 GO:0033218 amide binding 22/745 247/18639 0.0890688259109312 2.22839442436758 0.000395604704499622 0.0128914397272132 GO:0061631 ubiquitin conjugating enzyme activity 7/745 35/18639 0.2 5.00375838926174 0.000400269541851375 0.0128914397272132 GO:0036041 long-chain fatty acid binding 5/745 17/18639 0.294117647058824 7.35846821950257 0.000417023613559434 0.0129833351688171 GO:0005345 purine nucleobase transmembrane transporter activity 4/745 10/18639 0.4 10.0075167785235 0.000438366637693427 0.0132075625679246 GO:0005484 SNAP receptor activity 7/745 36/18639 0.194444444444444 4.86476510067114 0.000479942105047339 0.0140083101910692 GO:0005504 fatty acid binding 8/745 47/18639 0.170212765957447 4.2585177780951 0.000495016219215791 0.014010459052956 GO:0098641 cadherin binding involved in cell-cell adhesion 5/745 18/18639 0.277777777777778 6.9496644295302 0.000558531063004522 0.0153431768484183 GO:0015205 nucleobase transmembrane transporter activity 4/745 11/18639 0.363636363636364 9.09774252593045 0.00066712581735513 0.0178027289545626 GO:0051019 mitogen-activated protein kinase binding 6/745 28/18639 0.214285714285714 5.36116970278044 0.000708135487445486 0.018372181813169 GO:0120227 acyl-CoA binding 5/745 19/18639 0.263157894736842 6.58389261744966 0.000733238975973352 0.0185093298259219 GO:0061134 peptidase regulator activity 20/745 226/18639 0.0884955752212389 2.21405238462909 0.000773721791022619 0.018569110614021 GO:0019003 GDP binding 10/745 75/18639 0.133333333333333 3.3358389261745 0.000775369715146485 0.018569110614021 GO:0004859 phospholipase inhibitor activity 4/745 12/18639 0.333333333333333 8.33959731543624 0.000969157502940662 0.0226298276936645 GO:0033293 monocarboxylic acid binding 10/745 79/18639 0.126582278481013 3.16693568940617 0.0011681431045273 0.0266108697470365 GO:0005126 cytokine receptor binding 22/745 275/18639 0.08 2.0015033557047 0.00163558098903209 0.0362983807957197 GO:0005543 phospholipid binding 34/745 497/18639 0.06841046277666 1.71154713515995 0.00169746791268705 0.0362983807957197 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 10/745 83/18639 0.120481927710843 3.0143122826878 0.00170998796039793 0.0362983807957197 GO:0004601 peroxidase activity 8/745 57/18639 0.140350877192982 3.51140939597315 0.0018321638464212 0.0371901681158199 GO:0019763 immunoglobulin receptor activity 4/745 14/18639 0.285714285714286 7.14822627037392 0.00183854288331888 0.0371901681158199 GO:0004860 protein kinase inhibitor activity 10/745 84/18639 0.119047619047619 2.9784276126558 0.00187312863589199 0.0371901681158199 GO:0141110 transporter inhibitor activity 7/745 45/18639 0.155555555555556 3.89181208053691 0.00191127202308282 0.0371901681158199 GO:0005178 integrin binding 15/745 161/18639 0.093167701863354 2.33094334903497 0.00204445244929376 0.0389697670947014 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 8/745 59/18639 0.135593220338983 3.39237856899101 0.00229280179794205 0.0428295375855576 GO:0005041 low-density lipoprotein particle receptor activity 4/745 15/18639 0.266666666666667 6.67167785234899 0.00242844232252865 0.0444738260635639 GO:0015399 primary active transmembrane transporter activity 15/745 166/18639 0.0903614457831325 2.26073421201585 0.00275138261697677 0.0494190646972366 GO:0019905 syntaxin binding 8/745 61/18639 0.131147540983607 3.28115304213885 0.00283966253866821 0.0500423549267191 GO:0019210 kinase inhibitor activity 10/745 90/18639 0.111111111111111 2.77986577181208 0.00313506241125436 0.0523119796396972 GO:0000062 fatty-acyl-CoA binding 4/745 16/18639 0.25 6.25469798657718 0.00313647843664137 0.0523119796396972 GO:0055102 lipase inhibitor activity 4/745 16/18639 0.25 6.25469798657718 0.00313647843664137 0.0523119796396972 GO:0019865 immunoglobulin binding 5/745 26/18639 0.192307692307692 4.81130614352091 0.00329060130397573 0.0539196775072515 GO:0000149 SNARE binding 11/745 106/18639 0.10377358490566 2.59628973027732 0.00341444077592004 0.0549842704260227 GO:1901681 sulfur compound binding 21/745 275/18639 0.0763636363636364 1.91052593044539 0.00358216081796411 0.0567074271860758 GO:0030169 low-density lipoprotein particle binding 4/745 17/18639 0.235294117647059 5.88677457560205 0.00397323376682043 0.0608360711182013 GO:1901567 fatty acid derivative binding 4/745 17/18639 0.235294117647059 5.88677457560205 0.00397323376682043 0.0608360711182013 GO:0030228 lipoprotein particle receptor activity 4/745 18/18639 0.222222222222222 5.55973154362416 0.00494886311076784 0.0652218310505056 GO:0034185 apolipoprotein binding 4/745 18/18639 0.222222222222222 5.55973154362416 0.00494886311076784 0.0652218310505056 GO:0033192 calmodulin-dependent protein phosphatase activity 9/745 81/18639 0.111111111111111 2.77986577181208 0.0049579764503061 0.0652218310505056 GO:0140791 histone H2AXS140 phosphatase activity 9/745 81/18639 0.111111111111111 2.77986577181208 0.0049579764503061 0.0652218310505056 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 9/745 81/18639 0.111111111111111 2.77986577181208 0.0049579764503061 0.0652218310505056 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 9/745 81/18639 0.111111111111111 2.77986577181208 0.0049579764503061 0.0652218310505056 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 9/745 81/18639 0.111111111111111 2.77986577181208 0.0049579764503061 0.0652218310505056 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 9/745 81/18639 0.111111111111111 2.77986577181208 0.0049579764503061 0.0652218310505056 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 9/745 81/18639 0.111111111111111 2.77986577181208 0.0049579764503061 0.0652218310505056 GO:1990439 MAP kinase serine/threonine phosphatase activity 9/745 81/18639 0.111111111111111 2.77986577181208 0.0049579764503061 0.0652218310505056 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 9/745 82/18639 0.109756097560976 2.74596496971681 0.00537708525791312 0.0687070608312945 GO:0033549 MAP kinase phosphatase activity 9/745 82/18639 0.109756097560976 2.74596496971681 0.00537708525791312 0.0687070608312945 GO:0008137 NADH dehydrogenase (ubiquinone) activity 6/745 41/18639 0.146341463414634 3.66128662628908 0.00544360010868929 0.0687070608312945 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 8/745 68/18639 0.117647058823529 2.94338728780103 0.00558732218142055 0.0695807855659573 GO:0140313 molecular sequestering activity 7/745 55/18639 0.127272727272727 3.18420988407566 0.00606209661336832 0.0712803650141877 GO:0015245 fatty acid transmembrane transporter activity 4/745 19/18639 0.210526315789474 5.26711409395973 0.00607302954671303 0.0712803650141877 GO:0048487 beta-tubulin binding 6/745 42/18639 0.142857142857143 3.57411313518696 0.00614083389562801 0.0712803650141877 GO:0005131 growth hormone receptor binding 3/745 10/18639 0.3 7.50563758389262 0.00618170189095204 0.0712803650141877 GO:0005381 iron ion transmembrane transporter activity 3/745 10/18639 0.3 7.50563758389262 0.00618170189095204 0.0712803650141877 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/745 10/18639 0.3 7.50563758389262 0.00618170189095204 0.0712803650141877 GO:0017018 myosin phosphatase activity 9/745 84/18639 0.107142857142857 2.68058485139022 0.00629707817091991 0.0717252562395023 GO:0003779 actin binding 29/745 443/18639 0.0654627539503386 1.63779902131592 0.00657818721085318 0.0740244199389984 GO:0170055 lipid transmembrane transporter activity 7/745 56/18639 0.125 3.12734899328859 0.00669510305262985 0.0742434857942649 GO:0009055 electron transfer activity 11/745 116/18639 0.0948275862068965 2.372471650081 0.00675663414615901 0.0742434857942649 GO:0008200 ion channel inhibitor activity 6/745 43/18639 0.13953488372093 3.49099422506633 0.00690083796577061 0.074946310000346 GO:0061135 endopeptidase regulator activity 15/745 184/18639 0.0815217391304348 2.0395754304056 0.00714374496211674 0.0766926183289314 GO:0050660 flavin adenine dinucleotide binding 9/745 86/18639 0.104651162790698 2.61824566879975 0.00733353490412048 0.0774056649635968 GO:0016504 peptidase activator activity 7/745 57/18639 0.12280701754386 3.07248322147651 0.00737591454149906 0.0774056649635968 GO:0003954 NADH dehydrogenase activity 6/745 44/18639 0.136363636363636 3.41165344722392 0.00772666622151192 0.079304464295518 GO:0016248 channel inhibitor activity 6/745 44/18639 0.136363636363636 3.41165344722392 0.00772666622151192 0.079304464295518 GO:0005518 collagen binding 8/745 72/18639 0.111111111111111 2.77986577181208 0.00787536298900616 0.0799520546927364 GO:0004722 protein serine/threonine phosphatase activity 10/745 103/18639 0.0970873786407767 2.42900892682609 0.00815798554285743 0.0819307365271918 GO:0032050 clathrin heavy chain binding 3/745 11/18639 0.272727272727273 6.82330689444783 0.00824966791855088 0.0819701046375162 GO:0140789 histone phosphatase activity 12/745 136/18639 0.0882352941176471 2.20754046585077 0.00840881229949972 0.0826540875875437 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/745 88/18639 0.102272727272727 2.55874008541794 0.00849549508394454 0.0826540875875437 GO:0008009 chemokine activity 6/745 45/18639 0.133333333333333 3.3358389261745 0.00862134225203948 0.0830137491072668 GO:0010314 phosphatidylinositol-5-phosphate binding 4/745 21/18639 0.19047619047619 4.76548418024928 0.0088028613041962 0.0838640326814041 GO:0001786 phosphatidylserine binding 7/745 59/18639 0.11864406779661 2.96833124786714 0.0088892283034893 0.0838640326814041 GO:0030246 carbohydrate binding 20/745 280/18639 0.0714285714285714 1.78705656759348 0.00904040340758796 0.0844373678268716 GO:0008201 heparin binding 14/745 172/18639 0.0813953488372093 2.03641329795536 0.00928267976653958 0.0858418109103759 GO:0030291 protein serine/threonine kinase inhibitor activity 6/745 46/18639 0.130434782608696 3.26332068864896 0.00958785002824165 0.0877946267291932 GO:0003995 acyl-CoA dehydrogenase activity 3/745 12/18639 0.25 6.25469798657718 0.0106765047237543 0.0931949103923973 GO:0004875 complement receptor activity 3/745 12/18639 0.25 6.25469798657718 0.0106765047237543 0.0931949103923973 GO:0008603 cAMP-dependent protein kinase regulator activity 3/745 12/18639 0.25 6.25469798657718 0.0106765047237543 0.0931949103923973 GO:0016208 AMP binding 3/745 12/18639 0.25 6.25469798657718 0.0106765047237543 0.0931949103923973 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/745 12/18639 0.25 6.25469798657718 0.0106765047237543 0.0931949103923973 GO:0005085 guanyl-nucleotide exchange factor activity 17/745 230/18639 0.0739130434782609 1.84921505690108 0.0112081847193213 0.0969300419245012 GO:0004602 glutathione peroxidase activity 4/745 23/18639 0.173913043478261 4.35109425153195 0.012228442254204 0.104783165737858 GO:0005507 copper ion binding 7/745 63/18639 0.111111111111111 2.77986577181208 0.0125799609915504 0.106692183556872 GO:0004866 endopeptidase inhibitor activity 13/745 161/18639 0.0807453416149068 2.02015090249698 0.0126796920501208 0.106692183556872 GO:0019955 cytokine binding 12/745 144/18639 0.0833333333333333 2.08489932885906 0.0129082776618937 0.107645815501863 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/745 13/18639 0.230769230769231 5.77356737222509 0.0134727022603021 0.108525864549762 GO:0008035 high-density lipoprotein particle binding 3/745 13/18639 0.230769230769231 5.77356737222509 0.0134727022603021 0.108525864549762 GO:0017154 semaphorin receptor activity 3/745 13/18639 0.230769230769231 5.77356737222509 0.0134727022603021 0.108525864549762 GO:0046332 SMAD binding 8/745 79/18639 0.10126582278481 2.53354855152493 0.0134785870318762 0.108525864549762 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 11/745 128/18639 0.0859375 2.15005243288591 0.0136570315650608 0.109022798989459 GO:0003924 GTPase activity 22/745 331/18639 0.0664652567975831 1.66288043147671 0.0140644447306724 0.111323655749559 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4/745 24/18639 0.166666666666667 4.16979865771812 0.0142198816176279 0.111608146477852 GO:0045296 cadherin binding 22/745 334/18639 0.0658682634730539 1.64794437969698 0.0154572348630298 0.120308811350582 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4/745 25/18639 0.16 4.0030067114094 0.0164052152384 0.1266319920055 GO:0044548 S100 protein binding 3/745 14/18639 0.214285714285714 5.36116970278044 0.0166456548176611 0.127235613705876 GO:1901981 phosphatidylinositol phosphate binding 14/745 185/18639 0.0756756756756757 1.89331398512607 0.0167558677578402 0.127235613705876 GO:0001221 transcription coregulator binding 10/745 115/18639 0.0869565217391304 2.17554712576598 0.0168952594718847 0.127259454409196 GO:0005201 extracellular matrix structural constituent 13/745 168/18639 0.0773809523809524 1.93597794822627 0.0175271484393383 0.130962853138736 GO:0030414 peptidase inhibitor activity 13/745 169/18639 0.0769230769230769 1.92452245740836 0.0183204910424463 0.132951294895885 GO:0043130 ubiquitin binding 9/745 100/18639 0.09 2.25169127516779 0.0186147062936109 0.132951294895885 GO:0019001 guanyl nucleotide binding 25/745 400/18639 0.0625 1.5636744966443 0.0187348611278535 0.132951294895885 GO:0032561 guanyl ribonucleotide binding 25/745 400/18639 0.0625 1.5636744966443 0.0187348611278535 0.132951294895885 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/745 26/18639 0.153846153846154 3.84904491481673 0.0187896904992044 0.132951294895885 GO:0008198 ferrous iron binding 4/745 26/18639 0.153846153846154 3.84904491481673 0.0187896904992044 0.132951294895885 GO:0030247 polysaccharide binding 4/745 26/18639 0.153846153846154 3.84904491481673 0.0187896904992044 0.132951294895885 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/745 15/18639 0.2 5.00375838926174 0.0201999579414442 0.13902904050512 GO:0120283 protein serine/threonine kinase binding 3/745 15/18639 0.2 5.00375838926174 0.0201999579414442 0.13902904050512 GO:0003925 G protein activity 6/745 54/18639 0.111111111111111 2.77986577181208 0.0202440572898248 0.13902904050512 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 6/745 54/18639 0.111111111111111 2.77986577181208 0.0202440572898248 0.13902904050512 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/745 40/18639 0.125 3.12734899328859 0.0208298078509933 0.142007595130129 GO:0005044 scavenger receptor activity 4/745 27/18639 0.148148148148148 3.70648769574944 0.0213778742800319 0.144447054746894 GO:0097110 scaffold protein binding 7/745 70/18639 0.1 2.50187919463087 0.0214969385544092 0.144447054746894 GO:0098632 cell-cell adhesion mediator activity 6/745 55/18639 0.109090909090909 2.72932275777913 0.0219806239032684 0.146642162326091 GO:0001530 lipopolysaccharide binding 5/745 41/18639 0.121951219512195 3.05107218857423 0.0229667811485355 0.152134564487462 GO:0004721 phosphoprotein phosphatase activity 13/745 175/18639 0.0742857142857143 1.85853883029722 0.0236613527406008 0.155631714505079 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/745 16/18639 0.1875 4.69102348993289 0.0241376839810142 0.156387380349693 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/745 16/18639 0.1875 4.69102348993289 0.0241376839810142 0.156387380349693 GO:0004197 cysteine-type endopeptidase activity 8/745 88/18639 0.0909090909090909 2.27443563148261 0.0243757690686579 0.156387380349693 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 10/745 122/18639 0.0819672131147541 2.05072065133678 0.0244459930739349 0.156387380349693 GO:0042379 chemokine receptor binding 7/745 72/18639 0.0972222222222222 2.43238255033557 0.0246903071910638 0.15687582936363 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 8/745 89/18639 0.0898876404494382 2.2488801749491 0.0258818804200871 0.162239438337996 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 8/745 89/18639 0.0898876404494382 2.2488801749491 0.0258818804200871 0.162239438337996 GO:0005319 lipid transporter activity 13/745 178/18639 0.0730337078651685 1.82721514214614 0.026728161445782 0.166427351935736 GO:0140793 histone H2AXY142 phosphatase activity 8/745 90/18639 0.0888888888888889 2.22389261744966 0.0274516155944792 0.169800059372474 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6/745 58/18639 0.103448275862069 2.58815089099745 0.0277845309796623 0.170728631151346 GO:0051020 GTPase binding 20/745 315/18639 0.0634920634920635 1.58849472674976 0.0285677583968411 0.17439402838333 GO:0045309 protein phosphorylated amino acid binding 6/745 59/18639 0.101694915254237 2.54428392674326 0.029923621848663 0.181484823419813 GO:0001968 fibronectin binding 4/745 30/18639 0.133333333333333 3.3358389261745 0.0304002540599506 0.183186047045122 GO:0005525 GTP binding 23/745 378/18639 0.0608465608465608 1.52230744646852 0.0306381404564382 0.183436046066111 GO:0098631 cell adhesion mediator activity 7/745 76/18639 0.0921052631578947 2.30436241610738 0.0320210161540126 0.19049445278884 GO:0051219 phosphoprotein binding 8/745 93/18639 0.0860215053763441 2.15215414591903 0.0325536901685355 0.191185144389689 GO:0008525 phosphatidylcholine transporter activity 3/745 18/18639 0.166666666666667 4.16979865771812 0.0331605924958561 0.191185144389689 GO:0031690 adrenergic receptor binding 3/745 18/18639 0.166666666666667 4.16979865771812 0.0331605924958561 0.191185144389689 GO:0050811 GABA receptor binding 3/745 18/18639 0.166666666666667 4.16979865771812 0.0331605924958561 0.191185144389689 GO:0070064 proline-rich region binding 3/745 18/18639 0.166666666666667 4.16979865771812 0.0331605924958561 0.191185144389689 GO:0005539 glycosaminoglycan binding 16/745 242/18639 0.0661157024793388 1.65413500471463 0.034194410933645 0.195936072466408 GO:0015026 coreceptor activity 6/745 61/18639 0.0983606557377049 2.46086478160414 0.0345186532511001 0.196587939856875 GO:0042578 phosphoric ester hydrolase activity 22/745 363/18639 0.0606060606060606 1.51629042098841 0.0352164044285363 0.199346192340927 GO:0030276 clathrin binding 5/745 46/18639 0.108695652173913 2.71943390720747 0.0357505847833644 0.201150880648568 GO:0043395 heparan sulfate proteoglycan binding 3/745 19/18639 0.157894736842105 3.9503355704698 0.0382395105488204 0.212593469360704 GO:0140036 ubiquitin-modified protein reader activity 3/745 19/18639 0.157894736842105 3.9503355704698 0.0382395105488204 0.212593469360704 GO:0001784 phosphotyrosine residue binding 5/745 47/18639 0.106382978723404 2.66157361130944 0.0387412347692987 0.214108362571154 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 10/745 132/18639 0.0757575757575758 1.89536302623551 0.0390600627258696 0.214600579917424 GO:0019207 kinase regulator activity 18/745 287/18639 0.0627177700348432 1.56912283983818 0.040277126686049 0.219888396593403 GO:0141108 transporter regulator activity 12/745 170/18639 0.0705882352941176 1.76603237268062 0.0404933663962156 0.219888396593403 GO:0038187 pattern recognition receptor activity 5/745 48/18639 0.104166666666667 2.60612416107383 0.041879977773039 0.226103463815136 GO:0004725 protein tyrosine phosphatase activity 8/745 98/18639 0.0816326530612245 2.04235036296398 0.0424267789907618 0.227739146996388 GO:0001972 retinoic acid binding 3/745 20/18639 0.15 3.75281879194631 0.0436897444594384 0.229248434410761 GO:0016004 phospholipase activator activity 3/745 20/18639 0.15 3.75281879194631 0.0436897444594384 0.229248434410761 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/745 20/18639 0.15 3.75281879194631 0.0436897444594384 0.229248434410761 GO:0043024 ribosomal small subunit binding 3/745 20/18639 0.15 3.75281879194631 0.0436897444594384 0.229248434410761 GO:0035254 glutamate receptor binding 5/745 49/18639 0.102040816326531 2.55293795370497 0.0451677681325837 0.235679862770018 GO:0051427 hormone receptor binding 4/745 34/18639 0.117647058823529 2.94338728780103 0.0454433391955957 0.235800437826035 GO:0003823 antigen binding 12/745 174/18639 0.0689655172413793 1.72543392733164 0.0469297942257582 0.242168109430156 GO:0016791 phosphatase activity 17/745 273/18639 0.0622710622710623 1.55794675123534 0.0478625390804395 0.245624239017201 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/745 21/18639 0.142857142857143 3.57411313518696 0.0495042249853121 0.252660907848533 GO:0019887 protein kinase regulator activity 16/745 255/18639 0.0627450980392157 1.56980655349388 0.050819452837586 0.257963961686442 GO:0032182 ubiquitin-like protein binding 9/745 120/18639 0.075 1.87640939597315 0.0513064707183007 0.25902834405888 GO:0001664 G protein-coupled receptor binding 18/745 297/18639 0.0606060606060606 1.51629042098841 0.0529490930744491 0.26588415554589 GO:0045505 dynein intermediate chain binding 4/745 36/18639 0.111111111111111 2.77986577181208 0.0542665357631418 0.271042483437296 GO:0140035 ubiquitin-like protein reader activity 3/745 22/18639 0.136363636363636 3.41165344722392 0.0556746337337527 0.274242246272465 GO:0099106 ion channel regulator activity 11/745 160/18639 0.06875 1.72004194630872 0.0565117554196734 0.274242246272465 GO:0030695 GTPase regulator activity 27/745 489/18639 0.0552147239263804 1.38140569028698 0.0569940677420948 0.274242246272465 GO:0004090 carbonyl reductase (NADPH) activity 2/745 10/18639 0.2 5.00375838926174 0.0580311489005601 0.274242246272465 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/745 10/18639 0.2 5.00375838926174 0.0580311489005601 0.274242246272465 GO:0004955 prostaglandin receptor activity 2/745 10/18639 0.2 5.00375838926174 0.0580311489005601 0.274242246272465 GO:0015643 toxic substance binding 2/745 10/18639 0.2 5.00375838926174 0.0580311489005601 0.274242246272465 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/745 10/18639 0.2 5.00375838926174 0.0580311489005601 0.274242246272465 GO:0043422 protein kinase B binding 2/745 10/18639 0.2 5.00375838926174 0.0580311489005601 0.274242246272465 GO:0070097 delta-catenin binding 2/745 10/18639 0.2 5.00375838926174 0.0580311489005601 0.274242246272465 GO:0060589 nucleoside-triphosphatase regulator activity 27/745 490/18639 0.0551020408163265 1.37858649500068 0.0581370072397731 0.274242246272465 GO:0005544 calcium-dependent phospholipid binding 5/745 53/18639 0.0943396226415094 2.3602633911612 0.0598193935018283 0.279356567653538 GO:1901505 carbohydrate derivative transmembrane transporter activity 5/745 53/18639 0.0943396226415094 2.3602633911612 0.0598193935018283 0.279356567653538 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/745 70/18639 0.0857142857142857 2.14446788111218 0.0606597484174883 0.281871666775791 GO:0031267 small GTPase binding 17/745 283/18639 0.0600706713780919 1.50289562928356 0.0627108098618858 0.289959883222779 GO:0005501 retinoid binding 4/745 38/18639 0.105263157894737 2.63355704697987 0.0639471663242938 0.291349528521417 GO:0019840 isoprenoid binding 4/745 38/18639 0.105263157894737 2.63355704697987 0.0639471663242938 0.291349528521417 GO:0042887 amide transmembrane transporter activity 4/745 38/18639 0.105263157894737 2.63355704697987 0.0639471663242938 0.291349528521417 GO:0015295 solute:proton symporter activity 3/745 24/18639 0.125 3.12734899328859 0.0690446597182647 0.296025302819827 GO:0060229 lipase activator activity 3/745 24/18639 0.125 3.12734899328859 0.0690446597182647 0.296025302819827 GO:0001851 complement component C3b binding 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0004954 prostanoid receptor activity 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0008199 ferric iron binding 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0008432 JUN kinase binding 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0015217 ADP transmembrane transporter activity 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0019107 myristoyltransferase activity 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0032794 GTPase activating protein binding 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0050786 RAGE receptor binding 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0140031 phosphorylation-dependent protein binding 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:1990948 ubiquitin ligase inhibitor activity 2/745 11/18639 0.181818181818182 4.54887126296522 0.0690937002298955 0.296025302819827 GO:0022804 active transmembrane transporter activity 25/745 457/18639 0.0547045951859956 1.36864288546547 0.0707411645237187 0.301699761028097 GO:0072341 modified amino acid binding 7/745 91/18639 0.0769230769230769 1.92452245740836 0.0718204521959975 0.304910465232098 GO:0031406 carboxylic acid binding 12/745 187/18639 0.0641711229946524 1.6054839751642 0.0725908251762393 0.306786564319491 GO:0016247 channel regulator activity 11/745 168/18639 0.0654761904761905 1.63813518696069 0.0744451687802027 0.30912307102107 GO:0015144 carbohydrate transmembrane transporter activity 4/745 40/18639 0.1 2.50187919463087 0.0744675492288444 0.30912307102107 GO:0061791 GTPase motor activity 4/745 40/18639 0.1 2.50187919463087 0.0744675492288444 0.30912307102107 GO:1990606 membrane scission GTPase motor activity 4/745 40/18639 0.1 2.50187919463087 0.0744675492288444 0.30912307102107 GO:0001848 complement binding 3/745 25/18639 0.12 3.00225503355705 0.0762227657837008 0.312245891412178 GO:0003707 nuclear steroid receptor activity 3/745 25/18639 0.12 3.00225503355705 0.0762227657837008 0.312245891412178 GO:0120020 cholesterol transfer activity 3/745 25/18639 0.12 3.00225503355705 0.0762227657837008 0.312245891412178 GO:0051015 actin filament binding 13/745 209/18639 0.062200956937799 1.5561928004881 0.0769773996601445 0.313535637000189 GO:0043177 organic acid binding 12/745 189/18639 0.0634920634920635 1.58849472674976 0.0772089898394469 0.313535637000189 GO:0031072 heat shock protein binding 9/745 131/18639 0.0687022900763359 1.7188483016548 0.0796711514465906 0.316999361912898 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/745 41/18639 0.0975609756097561 2.44085775085939 0.0800351998321211 0.316999361912898 GO:0042169 SH2 domain binding 4/745 41/18639 0.0975609756097561 2.44085775085939 0.0800351998321211 0.316999361912898 GO:0005095 GTPase inhibitor activity 2/745 12/18639 0.166666666666667 4.16979865771812 0.0807771393311238 0.316999361912898 GO:0015132 prostaglandin transmembrane transporter activity 2/745 12/18639 0.166666666666667 4.16979865771812 0.0807771393311238 0.316999361912898 GO:0015166 polyol transmembrane transporter activity 2/745 12/18639 0.166666666666667 4.16979865771812 0.0807771393311238 0.316999361912898 GO:0016840 carbon-nitrogen lyase activity 2/745 12/18639 0.166666666666667 4.16979865771812 0.0807771393311238 0.316999361912898 GO:0035259 nuclear glucocorticoid receptor binding 2/745 12/18639 0.166666666666667 4.16979865771812 0.0807771393311238 0.316999361912898 GO:0017022 myosin binding 6/745 76/18639 0.0789473684210526 1.9751677852349 0.0831972597228975 0.325130713728813 GO:0120014 phospholipid transfer activity 3/745 26/18639 0.115384615384615 2.88678368611255 0.0837140364729829 0.325787125274025 GO:0004867 serine-type endopeptidase inhibitor activity 7/745 95/18639 0.0736842105263158 1.84348993288591 0.0858882363157986 0.332861463564132 GO:0031593 polyubiquitin modification-dependent protein binding 5/745 59/18639 0.0847457627118644 2.12023660561938 0.0862711616744054 0.332963904974771 GO:0140030 modification-dependent protein binding 11/745 173/18639 0.0635838150289017 1.59079023936067 0.0872992175108687 0.335545140556178 GO:0051087 protein-folding chaperone binding 9/745 134/18639 0.0671641791044776 1.68036662325954 0.0887834717826569 0.339851486250006 GO:0017124 SH3 domain binding 8/745 115/18639 0.0695652173913043 1.74043770061278 0.089838953554327 0.342488092325475 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5/745 60/18639 0.0833333333333333 2.08489932885906 0.0911896473896968 0.342841869394117 GO:0004364 glutathione transferase activity 3/745 27/18639 0.111111111111111 2.77986577181208 0.0915060567471017 0.342841869394117 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/745 27/18639 0.111111111111111 2.77986577181208 0.0915060567471017 0.342841869394117 GO:0035255 ionotropic glutamate receptor binding 3/745 27/18639 0.111111111111111 2.77986577181208 0.0915060567471017 0.342841869394117 GO:0048156 tau protein binding 4/745 43/18639 0.0930232558139535 2.32732948337756 0.091767095662237 0.342841869394117 GO:0032396 inhibitory MHC class I receptor activity 2/745 13/18639 0.153846153846154 3.84904491481673 0.0930143097076367 0.344743512964019 GO:0071714 icosanoid transmembrane transporter activity 2/745 13/18639 0.153846153846154 3.84904491481673 0.0930143097076367 0.344743512964019 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/745 61/18639 0.0819672131147541 2.05072065133678 0.096249557580643 0.355324453677156 GO:0042626 ATPase-coupled transmembrane transporter activity 7/745 98/18639 0.0714285714285714 1.78705656759348 0.097396376086714 0.358142579783429 GO:0046915 transition metal ion transmembrane transporter activity 4/745 45/18639 0.0888888888888889 2.22389261744966 0.104266002195675 0.379859304659509 GO:0001618 virus receptor activity 6/745 81/18639 0.0740740740740741 1.85324384787472 0.105066191794843 0.379859304659509 GO:0005347 ATP transmembrane transporter activity 2/745 14/18639 0.142857142857143 3.57411313518696 0.105742418855966 0.379859304659509 GO:0032036 myosin heavy chain binding 2/745 14/18639 0.142857142857143 3.57411313518696 0.105742418855966 0.379859304659509 GO:0071933 Arp2/3 complex binding 2/745 14/18639 0.142857142857143 3.57411313518696 0.105742418855966 0.379859304659509 GO:0098847 sequence-specific single stranded DNA binding 2/745 14/18639 0.142857142857143 3.57411313518696 0.105742418855966 0.379859304659509 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/745 29/18639 0.103448275862069 2.58815089099745 0.107940446574661 0.386269644064113 GO:0140272 exogenous protein binding 6/745 82/18639 0.0731707317073171 1.83064331314454 0.109766369729222 0.391304539416387 GO:0001965 G-protein alpha-subunit binding 3/745 30/18639 0.1 2.50187919463087 0.11655602352074 0.403837137548942 GO:0031210 phosphatidylcholine binding 3/745 30/18639 0.1 2.50187919463087 0.11655602352074 0.403837137548942 GO:0003714 transcription corepressor activity 12/745 204/18639 0.0588235294117647 1.47169364390051 0.117697528857731 0.403837137548942 GO:0120013 lipid transfer activity 5/745 65/18639 0.0769230769230769 1.92452245740836 0.117860146814717 0.403837137548942 GO:0004953 icosanoid receptor activity 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0015250 water channel activity 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0017081 chloride channel regulator activity 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0030553 cGMP binding 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0031386 protein tag activity 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0050780 dopamine receptor binding 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0141047 molecular tag activity 2/745 15/18639 0.133333333333333 3.3358389261745 0.1189027974582 0.403837137548942 GO:0051117 ATPase binding 6/745 84/18639 0.0714285714285714 1.78705656759348 0.119482884966634 0.404337009271144 GO:0032266 phosphatidylinositol-3-phosphate binding 4/745 48/18639 0.0833333333333333 2.08489932885906 0.124367576388821 0.419347712444616 GO:0070273 phosphatidylinositol-4-phosphate binding 3/745 31/18639 0.0967741935483871 2.42117341415891 0.125418930483707 0.421371514646699 GO:0008013 beta-catenin binding 7/745 106/18639 0.0660377358490566 1.65218437381284 0.131967246051201 0.432516036847854 GO:0004708 MAP kinase kinase activity 2/745 16/18639 0.125 3.12734899328859 0.132440670812084 0.432516036847854 GO:0005159 insulin-like growth factor receptor binding 2/745 16/18639 0.125 3.12734899328859 0.132440670812084 0.432516036847854 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/745 16/18639 0.125 3.12734899328859 0.132440670812084 0.432516036847854 GO:0034450 ubiquitin-ubiquitin ligase activity 2/745 16/18639 0.125 3.12734899328859 0.132440670812084 0.432516036847854 GO:0043023 ribosomal large subunit binding 2/745 16/18639 0.125 3.12734899328859 0.132440670812084 0.432516036847854 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/745 16/18639 0.125 3.12734899328859 0.132440670812084 0.432516036847854 GO:0070411 I-SMAD binding 2/745 16/18639 0.125 3.12734899328859 0.132440670812084 0.432516036847854 GO:0120015 sterol transfer activity 3/745 32/18639 0.09375 2.34551174496644 0.134515287945479 0.437760553801665 GO:0005548 phospholipid transporter activity 5/745 68/18639 0.0735294117647059 1.83961705487564 0.135436587756859 0.43922837835037 GO:0005496 steroid binding 7/745 108/18639 0.0648148148148148 1.62158836689038 0.141453060586555 0.453982776549406 GO:0002039 p53 binding 5/745 69/18639 0.072463768115942 1.81295593813831 0.141540779289153 0.453982776549406 GO:0019956 chemokine binding 3/745 33/18639 0.0909090909090909 2.27443563148261 0.14383114691208 0.453982776549406 GO:0140416 transcription regulator inhibitor activity 3/745 33/18639 0.0909090909090909 2.27443563148261 0.14383114691208 0.453982776549406 GO:0005125 cytokine activity 13/745 234/18639 0.0555555555555556 1.38993288590604 0.145611682852884 0.453982776549406 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/745 17/18639 0.117647058823529 2.94338728780103 0.14630494190725 0.453982776549406 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/745 17/18639 0.117647058823529 2.94338728780103 0.14630494190725 0.453982776549406 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/745 17/18639 0.117647058823529 2.94338728780103 0.14630494190725 0.453982776549406 GO:0017110 nucleoside diphosphate phosphatase activity 2/745 17/18639 0.117647058823529 2.94338728780103 0.14630494190725 0.453982776549406 GO:0019198 transmembrane receptor protein phosphatase activity 2/745 17/18639 0.117647058823529 2.94338728780103 0.14630494190725 0.453982776549406 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/745 17/18639 0.117647058823529 2.94338728780103 0.14630494190725 0.453982776549406 GO:0045236 CXCR chemokine receptor binding 2/745 17/18639 0.117647058823529 2.94338728780103 0.14630494190725 0.453982776549406 GO:0048038 quinone binding 2/745 17/18639 0.117647058823529 2.94338728780103 0.14630494190725 0.453982776549406 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/745 52/18639 0.0769230769230769 1.92452245740836 0.153464798593914 0.474622920154688 GO:0046906 tetrapyrrole binding 9/745 152/18639 0.0592105263157895 1.48137583892617 0.155601535198537 0.47964301609054 GO:0000900 mRNA regulatory element binding translation repressor activity 2/745 18/18639 0.111111111111111 2.77986577181208 0.160447985583674 0.486553306932309 GO:0005372 water transmembrane transporter activity 2/745 18/18639 0.111111111111111 2.77986577181208 0.160447985583674 0.486553306932309 GO:0016854 racemase and epimerase activity 2/745 18/18639 0.111111111111111 2.77986577181208 0.160447985583674 0.486553306932309 GO:0017075 syntaxin-1 binding 2/745 18/18639 0.111111111111111 2.77986577181208 0.160447985583674 0.486553306932309 GO:0032393 MHC class I receptor activity 2/745 18/18639 0.111111111111111 2.77986577181208 0.160447985583674 0.486553306932309 GO:0016860 intramolecular oxidoreductase activity 4/745 53/18639 0.0754716981132075 1.88821071292896 0.161109321458574 0.486977690104558 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 18/745 349/18639 0.0515759312320917 1.29036749293283 0.162734816785481 0.490304254443999 GO:0005506 iron ion binding 9/745 154/18639 0.0584415584415584 1.46213719166739 0.16423980642573 0.493247521548654 GO:0035091 phosphatidylinositol binding 15/745 284/18639 0.0528169014084507 1.32141506758673 0.16674934333803 0.49917912396705 GO:0004033 aldo-keto reductase (NADPH) activity 3/745 36/18639 0.0833333333333333 2.08489932885906 0.172956394210085 0.508682159879545 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/745 36/18639 0.0833333333333333 2.08489932885906 0.172956394210085 0.508682159879545 GO:0048029 monosaccharide binding 5/745 74/18639 0.0675675675675676 1.69045891529113 0.173755187852089 0.508682159879545 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/745 19/18639 0.105263157894737 2.63355704697987 0.174825453234833 0.508682159879545 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/745 19/18639 0.105263157894737 2.63355704697987 0.174825453234833 0.508682159879545 GO:0042577 lipid phosphatase activity 2/745 19/18639 0.105263157894737 2.63355704697987 0.174825453234833 0.508682159879545 GO:0046624 sphingolipid transporter activity 2/745 19/18639 0.105263157894737 2.63355704697987 0.174825453234833 0.508682159879545 GO:0070003 threonine-type peptidase activity 2/745 19/18639 0.105263157894737 2.63355704697987 0.174825453234833 0.508682159879545 GO:0097001 ceramide binding 2/745 19/18639 0.105263157894737 2.63355704697987 0.174825453234833 0.508682159879545 GO:0030551 cyclic nucleotide binding 3/745 37/18639 0.0810810810810811 2.02855069834936 0.183011316858808 0.53084649051592 GO:0030170 pyridoxal phosphate binding 4/745 56/18639 0.0714285714285714 1.78705656759348 0.184830870975847 0.534464499973502 GO:0016408 C-acyltransferase activity 2/745 20/18639 0.1 2.50187919463087 0.18939608754321 0.544295217739564 GO:0016505 peptidase activator activity involved in apoptotic process 2/745 20/18639 0.1 2.50187919463087 0.18939608754321 0.544295217739564 GO:0003712 transcription coregulator activity 24/745 495/18639 0.0484848484848485 1.21303233679073 0.191234059764385 0.547891447300416 GO:0070279 vitamin B6 binding 4/745 57/18639 0.0701754385964912 1.75570469798658 0.192979189389184 0.55120049813302 GO:0001846 opsonin binding 2/745 21/18639 0.0952380952380952 2.38274209012464 0.204121546759831 0.579481837913927 GO:0005123 death receptor binding 2/745 21/18639 0.0952380952380952 2.38274209012464 0.204121546759831 0.579481837913927 GO:0020037 heme binding 8/745 142/18639 0.0563380281690141 1.40950940542584 0.208494732866365 0.589653257951042 GO:0004879 nuclear receptor activity 4/745 59/18639 0.0677966101694915 1.69618928449551 0.209598374346623 0.589653257951042 GO:0070063 RNA polymerase binding 4/745 59/18639 0.0677966101694915 1.69618928449551 0.209598374346623 0.589653257951042 GO:0003697 single-stranded DNA binding 7/745 121/18639 0.0578512396694215 1.4473681291253 0.210343469330451 0.589972373437362 GO:0050997 quaternary ammonium group binding 3/745 40/18639 0.075 1.87640939597315 0.214026489350599 0.596718630010328 GO:0071949 FAD binding 3/745 40/18639 0.075 1.87640939597315 0.214026489350599 0.596718630010328 GO:0008234 cysteine-type peptidase activity 10/745 187/18639 0.053475935828877 1.33790331263683 0.216169299729137 0.600899184366112 GO:0098531 ligand-modulated transcription factor activity 4/745 60/18639 0.0666666666666667 1.66791946308725 0.218056140557832 0.60328751135787 GO:0008093 cytoskeletal anchor activity 2/745 22/18639 0.0909090909090909 2.27443563148261 0.218966238062439 0.60328751135787 GO:0061133 endopeptidase activator activity 2/745 22/18639 0.0909090909090909 2.27443563148261 0.218966238062439 0.60328751135787 GO:0017080 sodium channel regulator activity 3/745 41/18639 0.0731707317073171 1.83064331314454 0.224604749049427 0.615193066311333 GO:0042287 MHC protein binding 3/745 41/18639 0.0731707317073171 1.83064331314454 0.224604749049427 0.615193066311333 GO:0000295 adenine nucleotide transmembrane transporter activity 2/745 23/18639 0.0869565217391304 2.17554712576598 0.233897159548796 0.627758468444183 GO:0005158 insulin receptor binding 2/745 23/18639 0.0869565217391304 2.17554712576598 0.233897159548796 0.627758468444183 GO:0016493 C-C chemokine receptor activity 2/745 23/18639 0.0869565217391304 2.17554712576598 0.233897159548796 0.627758468444183 GO:0042171 lysophosphatidic acid acyltransferase activity 2/745 23/18639 0.0869565217391304 2.17554712576598 0.233897159548796 0.627758468444183 GO:0043274 phospholipase binding 2/745 23/18639 0.0869565217391304 2.17554712576598 0.233897159548796 0.627758468444183 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/745 23/18639 0.0869565217391304 2.17554712576598 0.233897159548796 0.627758468444183 GO:0071617 lysophospholipid acyltransferase activity 2/745 23/18639 0.0869565217391304 2.17554712576598 0.233897159548796 0.627758468444183 GO:0008307 structural constituent of muscle 3/745 42/18639 0.0714285714285714 1.78705656759348 0.235281802292638 0.627866295260926 GO:0042056 chemoattractant activity 3/745 42/18639 0.0714285714285714 1.78705656759348 0.235281802292638 0.627866295260926 GO:0019209 kinase activator activity 8/745 148/18639 0.0540540540540541 1.3523671322329 0.240811413701016 0.640791625061963 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/745 24/18639 0.0833333333333333 2.08489932885906 0.248883750442481 0.651141240653438 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/745 24/18639 0.0833333333333333 2.08489932885906 0.248883750442481 0.651141240653438 GO:0019957 C-C chemokine binding 2/745 24/18639 0.0833333333333333 2.08489932885906 0.248883750442481 0.651141240653438 GO:0030552 cAMP binding 2/745 24/18639 0.0833333333333333 2.08489932885906 0.248883750442481 0.651141240653438 GO:0050431 transforming growth factor beta binding 2/745 24/18639 0.0833333333333333 2.08489932885906 0.248883750442481 0.651141240653438 GO:0050699 WW domain binding 2/745 24/18639 0.0833333333333333 2.08489932885906 0.248883750442481 0.651141240653438 GO:0001223 transcription coactivator binding 3/745 44/18639 0.0681818181818182 1.70582672361196 0.25688363278741 0.670193611797322 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/745 86/18639 0.0581395348837209 1.45458092711097 0.260331289940591 0.677296447923433 GO:0019843 rRNA binding 4/745 65/18639 0.0615384615384615 1.53961796592669 0.261566446225677 0.678619613263285 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/745 25/18639 0.08 2.0015033557047 0.263897749108462 0.682771461682281 GO:0003774 cytoskeletal motor activity 8/745 153/18639 0.0522875816993464 1.30817212791157 0.268936599351407 0.693886143077939 GO:0001637 G protein-coupled chemoattractant receptor activity 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0004950 chemokine receptor activity 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0005160 transforming growth factor beta receptor binding 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0015216 purine nucleotide transmembrane transporter activity 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0030507 spectrin binding 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0043548 phosphatidylinositol 3-kinase binding 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0050750 low-density lipoprotein particle receptor binding 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0051139 metal cation:proton antiporter activity 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0070412 R-SMAD binding 2/745 26/18639 0.0769230769230769 1.92452245740836 0.278913058494751 0.697806061866678 GO:0016829 lyase activity 10/745 200/18639 0.05 1.25093959731544 0.279330193103529 0.697806061866678 GO:0050840 extracellular matrix binding 4/745 67/18639 0.0597014925373134 1.49365922067515 0.279421271025843 0.697806061866678 GO:0015631 tubulin binding 18/745 385/18639 0.0467532467532468 1.16970975333391 0.280339959268847 0.698233391885608 GO:1902936 phosphatidylinositol bisphosphate binding 6/745 111/18639 0.0540540540540541 1.3523671322329 0.283984674401554 0.705430015667689 GO:0032934 sterol binding 4/745 68/18639 0.0588235294117647 1.47169364390051 0.288420313730155 0.714547939055609 GO:0043495 protein-membrane adaptor activity 3/745 47/18639 0.0638297872340425 1.59694416678566 0.289731866066685 0.715898314566888 GO:0016853 isomerase activity 9/745 180/18639 0.05 1.25093959731544 0.293811987748333 0.724064370862647 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/745 48/18639 0.0625 1.5636744966443 0.300756152045209 0.735356664948234 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/745 48/18639 0.0625 1.5636744966443 0.300756152045209 0.735356664948234 GO:0140693 molecular condensate scaffold activity 3/745 48/18639 0.0625 1.5636744966443 0.300756152045209 0.735356664948234 GO:0002020 protease binding 7/745 136/18639 0.0514705882352941 1.28773193841295 0.301734752172912 0.735823129319842 GO:0019789 SUMO transferase activity 2/745 28/18639 0.0714285714285714 1.78705656759348 0.3088532858607 0.738005681380148 GO:0046625 sphingolipid binding 2/745 28/18639 0.0714285714285714 1.78705656759348 0.3088532858607 0.738005681380148 GO:0051959 dynein light intermediate chain binding 2/745 28/18639 0.0714285714285714 1.78705656759348 0.3088532858607 0.738005681380148 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/745 28/18639 0.0714285714285714 1.78705656759348 0.3088532858607 0.738005681380148 GO:0008017 microtubule binding 13/745 276/18639 0.0471014492753623 1.1784213597899 0.311729011973911 0.738005681380148 GO:0060590 ATPase regulator activity 3/745 49/18639 0.0612244897959184 1.53176277222298 0.311800625482184 0.738005681380148 GO:0051213 dioxygenase activity 5/745 93/18639 0.0537634408602151 1.34509634119939 0.314789797405889 0.738005681380148 GO:0005516 calmodulin binding 10/745 207/18639 0.0483091787439614 1.20863729209221 0.315384647662324 0.738005681380148 GO:0030295 protein kinase activator activity 7/745 139/18639 0.0503597122302158 1.25993916276375 0.320995408580279 0.738005681380148 GO:0032813 tumor necrosis factor receptor superfamily binding 3/745 50/18639 0.06 1.50112751677852 0.322855489494239 0.738005681380148 GO:0048020 CCR chemokine receptor binding 3/745 50/18639 0.06 1.50112751677852 0.322855489494239 0.738005681380148 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/745 29/18639 0.0689655172413793 1.72543392733164 0.323735718400407 0.738005681380148 GO:0043236 laminin binding 2/745 29/18639 0.0689655172413793 1.72543392733164 0.323735718400407 0.738005681380148 GO:0051861 glycolipid binding 2/745 29/18639 0.0689655172413793 1.72543392733164 0.323735718400407 0.738005681380148 GO:0097472 cyclin-dependent protein kinase activity 2/745 29/18639 0.0689655172413793 1.72543392733164 0.323735718400407 0.738005681380148 GO:0003743 translation initiation factor activity 3/745 51/18639 0.0588235294117647 1.47169364390051 0.333911319892545 0.738005681380148 GO:0030544 Hsp70 protein binding 3/745 51/18639 0.0588235294117647 1.47169364390051 0.333911319892545 0.738005681380148 GO:0003796 lysozyme activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0004382 GDP phosphatase activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0004935 adrenergic receptor activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0005031 tumor necrosis factor receptor activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0005337 nucleoside transmembrane transporter activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0005522 profilin binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0005528 FK506 binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0016783 sulfurtransferase activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0016868 intramolecular phosphotransferase activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0030957 Tat protein binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0031419 cobalamin binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0035256 G protein-coupled glutamate receptor binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0043121 neurotrophin binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0050308 sugar-phosphatase activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0050815 phosphoserine residue binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0097177 mitochondrial ribosome binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0098505 G-rich strand telomeric DNA binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0140999 histone H3K4 trimethyltransferase activity 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:1905394 retromer complex binding 1/745 10/18639 0.1 2.50187919463087 0.335026133731459 0.738005681380148 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/745 30/18639 0.0666666666666667 1.66791946308725 0.338534268034668 0.738789949638979 GO:0015215 nucleotide transmembrane transporter activity 2/745 30/18639 0.0666666666666667 1.66791946308725 0.338534268034668 0.738789949638979 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/745 30/18639 0.0666666666666667 1.66791946308725 0.338534268034668 0.738789949638979 GO:0004896 cytokine receptor activity 5/745 96/18639 0.0520833333333333 1.30306208053691 0.33859056650039 0.738789949638979 GO:0005080 protein kinase C binding 3/745 52/18639 0.0576923076923077 1.44339184305627 0.344959066094502 0.738789949638979 GO:0019902 phosphatase binding 9/745 190/18639 0.0473684210526316 1.18510067114094 0.349521884747524 0.738789949638979 GO:0070325 lipoprotein particle receptor binding 2/745 31/18639 0.0645161290322581 1.61411560943927 0.353231877520942 0.738789949638979 GO:0019903 protein phosphatase binding 7/745 144/18639 0.0486111111111111 1.21619127516779 0.35351069381703 0.738789949638979 GO:0005246 calcium channel regulator activity 3/745 53/18639 0.0566037735849057 1.41615803469672 0.355990050772658 0.738789949638979 GO:0140034 methylation-dependent protein binding 4/745 76/18639 0.0526315789473684 1.31677852348993 0.361359602174029 0.738789949638979 GO:0004016 adenylate cyclase activity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0005114 type II transforming growth factor beta receptor binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0005225 volume-sensitive anion channel activity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0008526 phosphatidylinositol transfer activity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0010854 adenylate cyclase regulator activity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0019203 carbohydrate phosphatase activity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0019215 intermediate filament binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0031731 CCR6 chemokine receptor binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0032404 mismatch repair complex binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0034056 estrogen response element binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0034713 type I transforming growth factor beta receptor binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0045294 alpha-catenin binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0048185 activin binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0050998 nitric-oxide synthase binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0070697 activin receptor binding 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0097493 structural molecule activity conferring elasticity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/745 11/18639 0.0909090909090909 2.27443563148261 0.361619377081616 0.738789949638979 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/745 122/18639 0.0491803278688525 1.23043239080207 0.361783161253049 0.738789949638979 GO:0019787 ubiquitin-like protein transferase activity 21/745 479/18639 0.0438413361169102 1.09685726695717 0.362883947786325 0.738789949638979 GO:0015485 cholesterol binding 3/745 54/18639 0.0555555555555556 1.38993288590604 0.366995968363635 0.738789949638979 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/745 54/18639 0.0555555555555556 1.38993288590604 0.366995968363635 0.738789949638979 GO:0050661 NADP binding 3/745 54/18639 0.0555555555555556 1.38993288590604 0.366995968363635 0.738789949638979 GO:0022884 macromolecule transmembrane transporter activity 2/745 32/18639 0.0625 1.5636744966443 0.367812983492639 0.738789949638979 GO:0030515 snoRNA binding 2/745 32/18639 0.0625 1.5636744966443 0.367812983492639 0.738789949638979 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/745 32/18639 0.0625 1.5636744966443 0.367812983492639 0.738789949638979 GO:0051059 NF-kappaB binding 2/745 32/18639 0.0625 1.5636744966443 0.367812983492639 0.738789949638979 GO:0008374 O-acyltransferase activity 3/745 55/18639 0.0545454545454545 1.36466137888957 0.377968882551147 0.740980650185446 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/745 33/18639 0.0606060606060606 1.51629042098841 0.382263424562353 0.740980650185446 GO:0030296 protein tyrosine kinase activator activity 2/745 33/18639 0.0606060606060606 1.51629042098841 0.382263424562353 0.740980650185446 GO:0004000 adenosine deaminase activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0004300 enoyl-CoA hydratase activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0005025 transforming growth factor beta receptor activity, type I 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0005026 transforming growth factor beta receptor activity, type II 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0005078 MAP-kinase scaffold activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0005247 voltage-gated chloride channel activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0005527 macrolide binding 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0008504 monoamine transmembrane transporter activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0015368 calcium:monoatomic cation antiporter activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0016361 activin receptor activity, type I 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0016362 activin receptor activity, type II 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0016801 hydrolase activity, acting on ether bonds 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0016803 ether hydrolase activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0017002 activin receptor activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0031543 peptidyl-proline dioxygenase activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0043047 single-stranded telomeric DNA binding 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0070410 co-SMAD binding 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0097371 MDM2/MDM4 family protein binding 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0097677 STAT family protein binding 1/745 12/18639 0.0833333333333333 2.08489932885906 0.387150489604387 0.740980650185446 GO:0019842 vitamin binding 7/745 150/18639 0.0466666666666667 1.16754362416107 0.392905800269668 0.750458113398507 GO:0140297 DNA-binding transcription factor binding 21/745 488/18639 0.0430327868852459 1.07662834195181 0.395494494834655 0.752838843456259 GO:0008376 acetylgalactosaminyltransferase activity 2/745 34/18639 0.0588235294117647 1.47169364390051 0.396570354368822 0.752838843456259 GO:0030332 cyclin binding 2/745 34/18639 0.0588235294117647 1.47169364390051 0.396570354368822 0.752838843456259 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/745 57/18639 0.0526315789473684 1.31677852348993 0.399785780242317 0.75456805530619 GO:0005096 GTPase activator activity 12/745 271/18639 0.044280442804428 1.10784318581441 0.400051489451698 0.75456805530619 GO:0005154 epidermal growth factor receptor binding 2/745 35/18639 0.0571428571428571 1.42964525407478 0.410722159320094 0.75456805530619 GO:0016229 steroid dehydrogenase activity 2/745 35/18639 0.0571428571428571 1.42964525407478 0.410722159320094 0.75456805530619 GO:0043015 gamma-tubulin binding 2/745 35/18639 0.0571428571428571 1.42964525407478 0.410722159320094 0.75456805530619 GO:0004465 lipoprotein lipase activity 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0004535 poly(A)-specific ribonuclease activity 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0005035 death receptor activity 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0035673 oligopeptide transmembrane transporter activity 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0045159 myosin II binding 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0046975 histone H3K36 methyltransferase activity 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0061459 L-arginine transmembrane transporter activity 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0070123 transforming growth factor beta receptor activity, type III 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0140666 annealing activity 1/745 13/18639 0.0769230769230769 1.92452245740836 0.411661837929117 0.75456805530619 GO:0035591 signaling adaptor activity 6/745 129/18639 0.0465116279069767 1.16366474168878 0.412023242190746 0.75456805530619 GO:0015459 potassium channel regulator activity 3/745 59/18639 0.0508474576271186 1.27214196337163 0.421384487829458 0.76692696277934 GO:0000993 RNA polymerase II complex binding 2/745 36/18639 0.0555555555555556 1.38993288590604 0.424708380797154 0.76692696277934 GO:0016409 palmitoyltransferase activity 2/745 36/18639 0.0555555555555556 1.38993288590604 0.424708380797154 0.76692696277934 GO:0055106 ubiquitin-protein transferase regulator activity 2/745 36/18639 0.0555555555555556 1.38993288590604 0.424708380797154 0.76692696277934 GO:0016755 aminoacyltransferase activity 21/745 496/18639 0.0423387096774194 1.05926336869452 0.424772255394434 0.76692696277934 GO:0008135 translation factor activity, RNA binding 4/745 83/18639 0.0481927710843374 1.20572491307512 0.42507980072672 0.76692696277934 GO:0030165 PDZ domain binding 4/745 83/18639 0.0481927710843374 1.20572491307512 0.42507980072672 0.76692696277934 GO:0004842 ubiquitin-protein transferase activity 19/745 449/18639 0.0423162583518931 1.05870166365226 0.432518595216456 0.76692696277934 GO:0005179 hormone activity 6/745 132/18639 0.0454545454545455 1.13721781574131 0.433471200341145 0.76692696277934 GO:0180051 translation factor activity 4/745 84/18639 0.0476190476190476 1.19137104506232 0.434074390061612 0.76692696277934 GO:0005344 oxygen carrier activity 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0005545 1-phosphatidylinositol binding 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0008191 metalloendopeptidase inhibitor activity 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0008195 phosphatidate phosphatase activity 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0015926 glucosidase activity 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0030983 mismatched DNA binding 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0042043 neurexin family protein binding 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0061783 peptidoglycan muralytic activity 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0098821 BMP receptor activity 1/745 14/18639 0.0714285714285714 1.78705656759348 0.435194100934743 0.76692696277934 GO:0030280 structural constituent of skin epidermis 2/745 37/18639 0.0540540540540541 1.3523671322329 0.43851964159363 0.769882227910622 GO:0042805 actinin binding 2/745 37/18639 0.0540540540540541 1.3523671322329 0.43851964159363 0.769882227910622 GO:0042162 telomeric DNA binding 2/745 38/18639 0.0526315789473684 1.31677852348993 0.45214757637794 0.785978747540677 GO:0000774 adenyl-nucleotide exchange factor activity 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0004129 cytochrome-c oxidase activity 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0005523 tropomyosin binding 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0008242 omega peptidase activity 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0010181 FMN binding 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0015929 hexosaminidase activity 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0016846 carbon-sulfur lyase activity 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0033130 acetylcholine receptor binding 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0042809 nuclear vitamin D receptor binding 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0047372 monoacylglycerol lipase activity 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0050700 CARD domain binding 1/745 15/18639 0.0666666666666667 1.66791946308725 0.457786336897354 0.785978747540677 GO:0008081 phosphoric diester hydrolase activity 4/745 87/18639 0.0459770114942529 1.15028928488776 0.460807145228697 0.78971352962129 GO:0019838 growth factor binding 6/745 136/18639 0.0441176470588235 1.10377023292538 0.461846179015396 0.790044562638058 GO:0043022 ribosome binding 5/745 112/18639 0.0446428571428571 1.11691035474593 0.465555265628775 0.794933488294836 GO:0016922 nuclear receptor binding 6/745 137/18639 0.0437956204379562 1.09571351589673 0.468886636790792 0.799160800661679 GO:0046943 carboxylic acid transmembrane transporter activity 8/745 188/18639 0.0425531914893617 1.06462944452378 0.479353023899794 0.804004719575772 GO:0005024 transforming growth factor beta receptor activity 1/745 16/18639 0.0625 1.5636744966443 0.479476047969705 0.804004719575772 GO:0005149 interleukin-1 receptor binding 1/745 16/18639 0.0625 1.5636744966443 0.479476047969705 0.804004719575772 GO:0008142 oxysterol binding 1/745 16/18639 0.0625 1.5636744966443 0.479476047969705 0.804004719575772 GO:0008296 3'-5'-DNA exonuclease activity 1/745 16/18639 0.0625 1.5636744966443 0.479476047969705 0.804004719575772 GO:0016722 oxidoreductase activity, acting on metal ions 1/745 16/18639 0.0625 1.5636744966443 0.479476047969705 0.804004719575772 GO:0019841 retinol binding 1/745 16/18639 0.0625 1.5636744966443 0.479476047969705 0.804004719575772 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/745 16/18639 0.0625 1.5636744966443 0.479476047969705 0.804004719575772 GO:0140328 floppase activity 1/745 16/18639 0.0625 1.5636744966443 0.479476047969705 0.804004719575772 GO:0140767 enzyme-substrate adaptor activity 6/745 139/18639 0.0431654676258993 1.0799478537975 0.482890183082087 0.808278550176827 GO:0005342 organic acid transmembrane transporter activity 8/745 189/18639 0.0423280423280423 1.05899648449984 0.485341191398725 0.810927858258335 GO:0140318 protein transporter activity 2/745 41/18639 0.0487804878048781 1.22042887542969 0.49186159456389 0.818369801426633 GO:0140828 metal cation:monoatomic cation antiporter activity 2/745 41/18639 0.0487804878048781 1.22042887542969 0.49186159456389 0.818369801426633 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/745 91/18639 0.043956043956044 1.09972711851906 0.495735394176131 0.818369801426633 GO:0004549 tRNA-specific ribonuclease activity 1/745 17/18639 0.0588235294117647 1.47169364390051 0.500299242098609 0.818369801426633 GO:0016805 dipeptidase activity 1/745 17/18639 0.0588235294117647 1.47169364390051 0.500299242098609 0.818369801426633 GO:0030548 acetylcholine receptor regulator activity 1/745 17/18639 0.0588235294117647 1.47169364390051 0.500299242098609 0.818369801426633 GO:0031489 myosin V binding 1/745 17/18639 0.0588235294117647 1.47169364390051 0.500299242098609 0.818369801426633 GO:0051787 misfolded protein binding 1/745 17/18639 0.0588235294117647 1.47169364390051 0.500299242098609 0.818369801426633 GO:0070403 NAD+ binding 1/745 17/18639 0.0588235294117647 1.47169364390051 0.500299242098609 0.818369801426633 GO:0070492 oligosaccharide binding 1/745 17/18639 0.0588235294117647 1.47169364390051 0.500299242098609 0.818369801426633 GO:0019208 phosphatase regulator activity 5/745 117/18639 0.0427350427350427 1.06917914300465 0.503975752579678 0.818369801426633 GO:1990782 protein tyrosine kinase binding 5/745 117/18639 0.0427350427350427 1.06917914300465 0.503975752579678 0.818369801426633 GO:0043178 alcohol binding 4/745 92/18639 0.0434782608695652 1.08777356288299 0.504318706792784 0.818369801426633 GO:0004402 histone acetyltransferase activity 2/745 42/18639 0.0476190476190476 1.19137104506232 0.504690584177453 0.818369801426633 GO:0035198 miRNA binding 2/745 42/18639 0.0476190476190476 1.19137104506232 0.504690584177453 0.818369801426633 GO:0043175 RNA polymerase core enzyme binding 2/745 42/18639 0.0476190476190476 1.19137104506232 0.504690584177453 0.818369801426633 GO:0051879 Hsp90 protein binding 2/745 42/18639 0.0476190476190476 1.19137104506232 0.504690584177453 0.818369801426633 GO:0008514 organic anion transmembrane transporter activity 11/745 269/18639 0.0408921933085502 1.02307327661485 0.512698492879789 0.826447823091903 GO:0003777 microtubule motor activity 3/745 68/18639 0.0441176470588235 1.10377023292538 0.514644641667443 0.826447823091903 GO:1990841 promoter-specific chromatin binding 3/745 68/18639 0.0441176470588235 1.10377023292538 0.514644641667443 0.826447823091903 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/745 43/18639 0.0465116279069767 1.16366474168878 0.517307422171967 0.826447823091903 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/745 18/18639 0.0555555555555556 1.38993288590604 0.52029049248184 0.826447823091903 GO:0008308 voltage-gated monoatomic anion channel activity 1/745 18/18639 0.0555555555555556 1.38993288590604 0.52029049248184 0.826447823091903 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/745 18/18639 0.0555555555555556 1.38993288590604 0.52029049248184 0.826447823091903 GO:0035615 clathrin adaptor activity 1/745 18/18639 0.0555555555555556 1.38993288590604 0.52029049248184 0.826447823091903 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/745 18/18639 0.0555555555555556 1.38993288590604 0.52029049248184 0.826447823091903 GO:0070628 proteasome binding 1/745 18/18639 0.0555555555555556 1.38993288590604 0.52029049248184 0.826447823091903 GO:0099602 neurotransmitter receptor regulator activity 1/745 18/18639 0.0555555555555556 1.38993288590604 0.52029049248184 0.826447823091903 GO:1990381 ubiquitin-specific protease binding 1/745 18/18639 0.0555555555555556 1.38993288590604 0.52029049248184 0.826447823091903 GO:0030547 signaling receptor inhibitor activity 2/745 44/18639 0.0454545454545455 1.13721781574131 0.529708554999803 0.839979270576937 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0005229 intracellularly calcium-gated chloride channel activity 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0008301 DNA binding, bending 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0008381 mechanosensitive monoatomic ion channel activity 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0016918 retinal binding 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0030506 ankyrin binding 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0034987 immunoglobulin receptor binding 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0042800 histone H3K4 methyltransferase activity 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0042834 peptidoglycan binding 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0141147 intracellularly calcium-gated channel activity 1/745 19/18639 0.0526315789473684 1.31677852348993 0.539482994662229 0.841197190341439 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/745 45/18639 0.0444444444444444 1.11194630872483 0.541891050947915 0.843543735975587 GO:0003735 structural constituent of ribosome 7/745 175/18639 0.04 1.00075167785235 0.553223679919964 0.857050415038529 GO:0001614 purinergic nucleotide receptor activity 1/745 20/18639 0.05 1.25093959731544 0.557908621352704 0.857050415038529 GO:0005326 neurotransmitter transmembrane transporter activity 1/745 20/18639 0.05 1.25093959731544 0.557908621352704 0.857050415038529 GO:0010851 cyclase regulator activity 1/745 20/18639 0.05 1.25093959731544 0.557908621352704 0.857050415038529 GO:0016502 nucleotide receptor activity 1/745 20/18639 0.05 1.25093959731544 0.557908621352704 0.857050415038529 GO:0030742 GTP-dependent protein binding 1/745 20/18639 0.05 1.25093959731544 0.557908621352704 0.857050415038529 GO:0031418 L-ascorbic acid binding 1/745 20/18639 0.05 1.25093959731544 0.557908621352704 0.857050415038529 GO:0042288 MHC class I protein binding 1/745 20/18639 0.05 1.25093959731544 0.557908621352704 0.857050415038529 GO:0043539 protein serine/threonine kinase activator activity 3/745 73/18639 0.0410958904109589 1.02816953204008 0.562862044957883 0.862935005982203 GO:0061733 protein-lysine-acetyltransferase activity 2/745 47/18639 0.0425531914893617 1.06462944452378 0.565591253566985 0.862935005982203 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 9/745 229/18639 0.0393013100436681 0.983271299199906 0.568305236911572 0.862935005982203 GO:0035064 methylated histone binding 3/745 74/18639 0.0405405405405405 1.01427534917468 0.572150079784198 0.862935005982203 GO:0003713 transcription coactivator activity 10/745 256/18639 0.0390625 0.977296560402685 0.574878913674813 0.862935005982203 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0009975 cyclase activity 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0015125 bile acid transmembrane transporter activity 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0015174 basic amino acid transmembrane transporter activity 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0019200 carbohydrate kinase activity 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0051010 microtubule plus-end binding 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0140312 cargo adaptor activity 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:1904047 S-adenosyl-L-methionine binding 1/745 21/18639 0.0476190476190476 1.19137104506232 0.575597975082348 0.862935005982203 GO:0044183 protein folding chaperone 3/745 75/18639 0.04 1.00075167785235 0.581314582663345 0.870108686230071 GO:0001222 transcription corepressor binding 2/745 49/18639 0.0408163265306122 1.02117518148199 0.588395406079906 0.8757438762539 GO:0016763 pentosyltransferase activity 2/745 49/18639 0.0408163265306122 1.02117518148199 0.588395406079906 0.8757438762539 GO:0001216 DNA-binding transcription activator activity 19/745 491/18639 0.0386965376782077 0.968140625213576 0.591184792981311 0.8757438762539 GO:0008970 phospholipase A1 activity 1/745 22/18639 0.0454545454545455 1.13721781574131 0.592580438749963 0.8757438762539 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/745 22/18639 0.0454545454545455 1.13721781574131 0.592580438749963 0.8757438762539 GO:0016881 acid-amino acid ligase activity 1/745 22/18639 0.0454545454545455 1.13721781574131 0.592580438749963 0.8757438762539 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/745 22/18639 0.0454545454545455 1.13721781574131 0.592580438749963 0.8757438762539 GO:0140517 protein-RNA adaptor activity 1/745 22/18639 0.0454545454545455 1.13721781574131 0.592580438749963 0.8757438762539 GO:0015605 organophosphate ester transmembrane transporter activity 2/745 50/18639 0.04 1.00075167785235 0.599459569270976 0.884510644074395 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/745 23/18639 0.0434782608695652 1.08777356288299 0.608884224168197 0.890654042636939 GO:0005212 structural constituent of eye lens 1/745 23/18639 0.0434782608695652 1.08777356288299 0.608884224168197 0.890654042636939 GO:0016849 phosphorus-oxygen lyase activity 1/745 23/18639 0.0434782608695652 1.08777356288299 0.608884224168197 0.890654042636939 GO:0031681 G-protein beta-subunit binding 1/745 23/18639 0.0434782608695652 1.08777356288299 0.608884224168197 0.890654042636939 GO:0140102 catalytic activity, acting on a rRNA 1/745 23/18639 0.0434782608695652 1.08777356288299 0.608884224168197 0.890654042636939 GO:0016597 amino acid binding 2/745 51/18639 0.0392156862745098 0.981129095933675 0.610298273327239 0.890654042636939 GO:0016830 carbon-carbon lyase activity 2/745 51/18639 0.0392156862745098 0.981129095933675 0.610298273327239 0.890654042636939 GO:0030159 signaling receptor complex adaptor activity 2/745 52/18639 0.0384615384615385 0.962261228704182 0.620911841616548 0.89328792503103 GO:0019888 protein phosphatase regulator activity 4/745 107/18639 0.0373831775700935 0.935281941918083 0.624036580736374 0.89328792503103 GO:0004622 lysophospholipase activity 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0004806 triacylglycerol lipase activity 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0005540 hyaluronic acid binding 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0015149 hexose transmembrane transporter activity 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0030215 semaphorin receptor binding 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0035035 histone acetyltransferase binding 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0055056 D-glucose transmembrane transporter activity 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0070300 phosphatidic acid binding 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0070840 dynein complex binding 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0140612 DNA damage sensor activity 1/745 24/18639 0.0416666666666667 1.04244966442953 0.624536418678011 0.89328792503103 GO:0034212 protein N-acetyltransferase activity 2/745 53/18639 0.0377358490566038 0.94410535646448 0.631300931453563 0.901582675806771 GO:0008083 growth factor activity 6/745 162/18639 0.037037037037037 0.92662192393736 0.632676442080211 0.90214242362145 GO:0015101 organic cation transmembrane transporter activity 3/745 81/18639 0.037037037037037 0.92662192393736 0.633624657275879 0.90214242362145 GO:0008139 nuclear localization sequence binding 1/745 25/18639 0.04 1.00075167785235 0.639563029910076 0.902303791412438 GO:0015645 fatty acid ligase activity 1/745 25/18639 0.04 1.00075167785235 0.639563029910076 0.902303791412438 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/745 25/18639 0.04 1.00075167785235 0.639563029910076 0.902303791412438 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/745 25/18639 0.04 1.00075167785235 0.639563029910076 0.902303791412438 GO:0019707 protein-cysteine S-acyltransferase activity 1/745 25/18639 0.04 1.00075167785235 0.639563029910076 0.902303791412438 GO:0120515 fatty acid-CoA ligase activity 1/745 25/18639 0.04 1.00075167785235 0.639563029910076 0.902303791412438 GO:0051287 NAD binding 2/745 54/18639 0.037037037037037 0.92662192393736 0.641466506957022 0.902303791412438 GO:0140463 chromatin-protein adaptor activity 2/745 54/18639 0.037037037037037 0.92662192393736 0.641466506957022 0.902303791412438 GO:0004222 metalloendopeptidase activity 4/745 110/18639 0.0363636363636364 0.909774252593044 0.645665970082712 0.906845136928201 GO:0005254 chloride channel activity 3/745 83/18639 0.036144578313253 0.904293684806339 0.65001726662733 0.908966894148939 GO:0004529 DNA exonuclease activity 1/745 26/18639 0.0384615384615385 0.962261228704182 0.653989028766689 0.908966894148939 GO:0008143 poly(A) binding 1/745 26/18639 0.0384615384615385 0.962261228704182 0.653989028766689 0.908966894148939 GO:0008157 protein phosphatase 1 binding 1/745 26/18639 0.0384615384615385 0.962261228704182 0.653989028766689 0.908966894148939 GO:0015145 monosaccharide transmembrane transporter activity 1/745 26/18639 0.0384615384615385 0.962261228704182 0.653989028766689 0.908966894148939 GO:0052742 phosphatidylinositol kinase activity 1/745 26/18639 0.0384615384615385 0.962261228704182 0.653989028766689 0.908966894148939 GO:0097602 cullin family protein binding 1/745 26/18639 0.0384615384615385 0.962261228704182 0.653989028766689 0.908966894148939 GO:0004175 endopeptidase activity 15/745 405/18639 0.037037037037037 0.92662192393736 0.655985040394339 0.910386371067329 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 18/745 484/18639 0.0371900826446281 0.930450940151977 0.657455276840574 0.910972481872588 GO:0061630 ubiquitin protein ligase activity 13/745 353/18639 0.0368271954674221 0.921371941365477 0.658358057027834 0.910972481872588 GO:0005200 structural constituent of cytoskeleton 4/745 112/18639 0.0357142857142857 0.89352828379674 0.659621454621749 0.9113704713265 GO:0004674 protein serine/threonine kinase activity 16/745 433/18639 0.0369515011547344 0.924481919494087 0.662335327979862 0.911931369749982 GO:0001671 ATPase activator activity 1/745 27/18639 0.037037037037037 0.92662192393736 0.667838390694848 0.911931369749982 GO:0008266 poly(U) RNA binding 1/745 27/18639 0.037037037037037 0.92662192393736 0.667838390694848 0.911931369749982 GO:0008320 protein transmembrane transporter activity 1/745 27/18639 0.037037037037037 0.92662192393736 0.667838390694848 0.911931369749982 GO:0008395 steroid hydroxylase activity 1/745 27/18639 0.037037037037037 0.92662192393736 0.667838390694848 0.911931369749982 GO:0015252 proton channel activity 1/745 27/18639 0.037037037037037 0.92662192393736 0.667838390694848 0.911931369749982 GO:0016405 CoA-ligase activity 1/745 27/18639 0.037037037037037 0.92662192393736 0.667838390694848 0.911931369749982 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/745 27/18639 0.037037037037037 0.92662192393736 0.667838390694848 0.911931369749982 GO:0001217 DNA-binding transcription repressor activity 10/745 278/18639 0.0359712230215827 0.899956544831249 0.677756006949674 0.915365873938596 GO:0008408 3'-5' exonuclease activity 2/745 58/18639 0.0344827586206897 0.862716963665818 0.679922300109504 0.915365873938596 GO:0061980 regulatory RNA binding 2/745 58/18639 0.0344827586206897 0.862716963665818 0.679922300109504 0.915365873938596 GO:0016866 intramolecular transferase activity 1/745 28/18639 0.0357142857142857 0.89352828379674 0.681134135318334 0.915365873938596 GO:0036408 histone H3K14 acetyltransferase activity 1/745 28/18639 0.0357142857142857 0.89352828379674 0.681134135318334 0.915365873938596 GO:0046875 ephrin receptor binding 1/745 28/18639 0.0357142857142857 0.89352828379674 0.681134135318334 0.915365873938596 GO:0046966 nuclear thyroid hormone receptor binding 1/745 28/18639 0.0357142857142857 0.89352828379674 0.681134135318334 0.915365873938596 GO:0050698 proteoglycan sulfotransferase activity 1/745 28/18639 0.0357142857142857 0.89352828379674 0.681134135318334 0.915365873938596 GO:0051119 sugar transmembrane transporter activity 1/745 28/18639 0.0357142857142857 0.89352828379674 0.681134135318334 0.915365873938596 GO:0051537 2 iron, 2 sulfur cluster binding 1/745 28/18639 0.0357142857142857 0.89352828379674 0.681134135318334 0.915365873938596 GO:0097718 disordered domain specific binding 1/745 28/18639 0.0357142857142857 0.89352828379674 0.681134135318334 0.915365873938596 GO:0036002 pre-mRNA binding 2/745 59/18639 0.0338983050847458 0.848094642247753 0.688993802294769 0.924598004803612 GO:0003785 actin monomer binding 1/745 29/18639 0.0344827586206897 0.862716963665818 0.693898364493974 0.925858674910532 GO:0010484 histone H3 acetyltransferase activity 1/745 29/18639 0.0344827586206897 0.862716963665818 0.693898364493974 0.925858674910532 GO:0016417 S-acyltransferase activity 1/745 29/18639 0.0344827586206897 0.862716963665818 0.693898364493974 0.925858674910532 GO:0106222 lncRNA binding 1/745 29/18639 0.0344827586206897 0.862716963665818 0.693898364493974 0.925858674910532 GO:0001098 basal transcription machinery binding 2/745 60/18639 0.0333333333333333 0.833959731543624 0.697852692725929 0.926787014180884 GO:0001099 basal RNA polymerase II transcription machinery binding 2/745 60/18639 0.0333333333333333 0.833959731543624 0.697852692725929 0.926787014180884 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/745 60/18639 0.0333333333333333 0.833959731543624 0.697852692725929 0.926787014180884 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/745 30/18639 0.0333333333333333 0.833959731543624 0.70615229885464 0.926787014180884 GO:0008187 poly-pyrimidine tract binding 1/745 30/18639 0.0333333333333333 0.833959731543624 0.70615229885464 0.926787014180884 GO:0033612 receptor serine/threonine kinase binding 1/745 30/18639 0.0333333333333333 0.833959731543624 0.70615229885464 0.926787014180884 GO:0043995 histone H4K5 acetyltransferase activity 1/745 30/18639 0.0333333333333333 0.833959731543624 0.70615229885464 0.926787014180884 GO:0043996 histone H4K8 acetyltransferase activity 1/745 30/18639 0.0333333333333333 0.833959731543624 0.70615229885464 0.926787014180884 GO:0043997 histone H4K12 acetyltransferase activity 1/745 30/18639 0.0333333333333333 0.833959731543624 0.70615229885464 0.926787014180884 GO:0048019 receptor antagonist activity 1/745 30/18639 0.0333333333333333 0.833959731543624 0.70615229885464 0.926787014180884 GO:0051721 protein phosphatase 2A binding 1/745 30/18639 0.0333333333333333 0.833959731543624 0.70615229885464 0.926787014180884 GO:0016836 hydro-lyase activity 2/745 61/18639 0.0327868852459016 0.820288260534712 0.706501449782429 0.926787014180884 GO:0043021 ribonucleoprotein complex binding 6/745 177/18639 0.0338983050847458 0.848094642247753 0.715250303437624 0.932592261818855 GO:0004540 RNA nuclease activity 4/745 121/18639 0.0330578512396694 0.827067502357313 0.717736854592883 0.932592261818855 GO:0051082 unfolded protein binding 4/745 121/18639 0.0330578512396694 0.827067502357313 0.717736854592883 0.932592261818855 GO:0005164 tumor necrosis factor receptor binding 1/745 31/18639 0.032258064516129 0.807057804719636 0.717916312899097 0.932592261818855 GO:0016411 acylglycerol O-acyltransferase activity 1/745 31/18639 0.032258064516129 0.807057804719636 0.717916312899097 0.932592261818855 GO:0016878 acid-thiol ligase activity 1/745 31/18639 0.032258064516129 0.807057804719636 0.717916312899097 0.932592261818855 GO:0047499 calcium-independent phospholipase A2 activity 1/745 31/18639 0.032258064516129 0.807057804719636 0.717916312899097 0.932592261818855 GO:0061659 ubiquitin-like protein ligase activity 13/745 372/18639 0.0349462365591398 0.874312621779606 0.728820341018317 0.942022283199308 GO:0042910 xenobiotic transmembrane transporter activity 1/745 32/18639 0.03125 0.781837248322148 0.729209968686402 0.942022283199308 GO:0043425 bHLH transcription factor binding 1/745 32/18639 0.03125 0.781837248322148 0.729209968686402 0.942022283199308 GO:0070717 poly-purine tract binding 1/745 32/18639 0.03125 0.781837248322148 0.729209968686402 0.942022283199308 GO:0019239 deaminase activity 1/745 33/18639 0.0303030303030303 0.758145210494204 0.740052048190278 0.952077979352231 GO:0042923 neuropeptide binding 1/745 33/18639 0.0303030303030303 0.758145210494204 0.740052048190278 0.952077979352231 GO:0071889 14-3-3 protein binding 1/745 33/18639 0.0303030303030303 0.758145210494204 0.740052048190278 0.952077979352231 GO:0016407 acetyltransferase activity 3/745 96/18639 0.03125 0.781837248322148 0.74372218323106 0.954945757218644 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 9/745 268/18639 0.0335820895522388 0.840183311629771 0.748606131220994 0.954945757218644 GO:0008175 tRNA methyltransferase activity 1/745 34/18639 0.0294117647058824 0.735846821950257 0.750460584366686 0.954945757218644 GO:0015035 protein-disulfide reductase activity 1/745 34/18639 0.0294117647058824 0.735846821950257 0.750460584366686 0.954945757218644 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/745 34/18639 0.0294117647058824 0.735846821950257 0.750460584366686 0.954945757218644 GO:0016831 carboxy-lyase activity 1/745 34/18639 0.0294117647058824 0.735846821950257 0.750460584366686 0.954945757218644 GO:0019825 oxygen binding 1/745 34/18639 0.0294117647058824 0.735846821950257 0.750460584366686 0.954945757218644 GO:0090482 vitamin transmembrane transporter activity 1/745 34/18639 0.0294117647058824 0.735846821950257 0.750460584366686 0.954945757218644 GO:0042826 histone deacetylase binding 4/745 127/18639 0.031496062992126 0.787993447127834 0.752216760607186 0.955878169261376 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/745 67/18639 0.0298507462686567 0.746829610337574 0.754135984957399 0.957014959171482 GO:0000175 3'-5'-RNA exonuclease activity 1/745 35/18639 0.0285714285714286 0.714822627037392 0.760452890985704 0.961113667362175 GO:0004623 phospholipase A2 activity 1/745 35/18639 0.0285714285714286 0.714822627037392 0.760452890985704 0.961113667362175 GO:0010485 histone H4 acetyltransferase activity 1/745 35/18639 0.0285714285714286 0.714822627037392 0.760452890985704 0.961113667362175 GO:0140658 ATP-dependent chromatin remodeler activity 5/745 158/18639 0.0316455696202532 0.791733922351542 0.761752692625548 0.961455425557111 GO:0016298 lipase activity 4/745 130/18639 0.0307692307692308 0.769808982963345 0.76820063909838 0.962814701810624 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/745 130/18639 0.0307692307692308 0.769808982963345 0.76820063909838 0.962814701810624 GO:0008080 N-acetyltransferase activity 2/745 69/18639 0.0289855072463768 0.725182375255325 0.768464241213426 0.962814701810624 GO:0004190 aspartic-type endopeptidase activity 1/745 36/18639 0.0277777777777778 0.69496644295302 0.770045591276805 0.962814701810624 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/745 36/18639 0.0277777777777778 0.69496644295302 0.770045591276805 0.962814701810624 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/745 36/18639 0.0277777777777778 0.69496644295302 0.770045591276805 0.962814701810624 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/745 36/18639 0.0277777777777778 0.69496644295302 0.770045591276805 0.962814701810624 GO:0016782 transferase activity, transferring sulphur-containing groups 2/745 70/18639 0.0285714285714286 0.714822627037392 0.77535209412426 0.968153550684571 GO:0070001 aspartic-type peptidase activity 1/745 37/18639 0.027027027027027 0.676183566116452 0.779254645434671 0.971727421676879 GO:0005253 monoatomic anion channel activity 3/745 103/18639 0.029126213592233 0.728702678047827 0.785268088951393 0.976234856958576 GO:0000146 microfilament motor activity 1/745 38/18639 0.0263157894736842 0.658389261744966 0.788095377030799 0.976234856958576 GO:0005109 frizzled binding 1/745 38/18639 0.0263157894736842 0.658389261744966 0.788095377030799 0.976234856958576 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/745 38/18639 0.0263157894736842 0.658389261744966 0.788095377030799 0.976234856958576 GO:0043531 ADP binding 1/745 38/18639 0.0263157894736842 0.658389261744966 0.788095377030799 0.976234856958576 GO:0000217 DNA secondary structure binding 1/745 39/18639 0.0256410256410256 0.641507485802788 0.796582498374385 0.98250711890613 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/745 39/18639 0.0256410256410256 0.641507485802788 0.796582498374385 0.98250711890613 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/745 39/18639 0.0256410256410256 0.641507485802788 0.796582498374385 0.98250711890613 GO:0031491 nucleosome binding 2/745 74/18639 0.027027027027027 0.676183566116452 0.801139307174982 0.98250711890613 GO:0004497 monooxygenase activity 3/745 106/18639 0.0283018867924528 0.70807901734836 0.801289772331588 0.98250711890613 GO:0016874 ligase activity 5/745 167/18639 0.029940119760479 0.749065627134992 0.802161648556742 0.98250711890613 GO:0004532 RNA exonuclease activity 1/745 40/18639 0.025 0.625469798657718 0.804730134864229 0.98250711890613 GO:0015036 disulfide oxidoreductase activity 1/745 40/18639 0.025 0.625469798657718 0.804730134864229 0.98250711890613 GO:0030331 nuclear estrogen receptor binding 1/745 40/18639 0.025 0.625469798657718 0.804730134864229 0.98250711890613 GO:0071855 neuropeptide receptor binding 1/745 40/18639 0.025 0.625469798657718 0.804730134864229 0.98250711890613 GO:0140662 ATP-dependent protein folding chaperone 1/745 40/18639 0.025 0.625469798657718 0.804730134864229 0.98250711890613 GO:0003725 double-stranded RNA binding 2/745 75/18639 0.0266666666666667 0.667167785234899 0.807161902367082 0.984189578082055 GO:0070851 growth factor receptor binding 4/745 139/18639 0.0287769784172662 0.719965235864999 0.811322204950046 0.984494416650096 GO:0001727 lipid kinase activity 1/745 41/18639 0.024390243902439 0.610214437714847 0.812551848371737 0.984494416650096 GO:0008227 G protein-coupled amine receptor activity 1/745 41/18639 0.024390243902439 0.610214437714847 0.812551848371737 0.984494416650096 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/745 41/18639 0.024390243902439 0.610214437714847 0.812551848371737 0.984494416650096 GO:0051536 iron-sulfur cluster binding 2/745 76/18639 0.0263157894736842 0.658389261744966 0.813021580040871 0.984494416650096 GO:0015291 secondary active transmembrane transporter activity 9/745 287/18639 0.0313588850174216 0.784561419919089 0.814744484377123 0.984494416650096 GO:0004713 protein tyrosine kinase activity 4/745 140/18639 0.0285714285714286 0.714822627037392 0.815682780635712 0.984494416650096 GO:0004620 phospholipase activity 3/745 109/18639 0.0275229357798165 0.688590604026846 0.816296849192914 0.984494416650096 GO:0051540 metal cluster binding 2/745 77/18639 0.025974025974026 0.649838751852175 0.818721720942784 0.984494416650096 GO:0016859 cis-trans isomerase activity 1/745 42/18639 0.0238095238095238 0.59568552253116 0.820060659693549 0.984494416650096 GO:0019894 kinesin binding 1/745 42/18639 0.0238095238095238 0.59568552253116 0.820060659693549 0.984494416650096 GO:0031492 nucleosomal DNA binding 1/745 42/18639 0.0238095238095238 0.59568552253116 0.820060659693549 0.984494416650096 GO:0019199 transmembrane receptor protein kinase activity 2/745 78/18639 0.0256410256410256 0.641507485802788 0.8242656962023 0.988272349490306 GO:0008375 acetylglucosaminyltransferase activity 1/745 43/18639 0.0232558139534884 0.581832370844389 0.827269070110729 0.990601681389002 GO:0016835 carbon-oxygen lyase activity 2/745 79/18639 0.0253164556962025 0.633387137881234 0.829656862704592 0.992188872939935 GO:0001046 core promoter sequence-specific DNA binding 1/745 44/18639 0.0227272727272727 0.568608907870653 0.834189082090053 0.992525608499503 GO:0016790 thiolester hydrolase activity 1/745 44/18639 0.0227272727272727 0.568608907870653 0.834189082090053 0.992525608499503 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/745 44/18639 0.0227272727272727 0.568608907870653 0.834189082090053 0.992525608499503 GO:0043014 alpha-tubulin binding 1/745 44/18639 0.0227272727272727 0.568608907870653 0.834189082090053 0.992525608499503 GO:0030971 receptor tyrosine kinase binding 2/745 81/18639 0.0246913580246914 0.617747949291573 0.839994100659418 0.994425086832306 GO:0015293 symporter activity 4/745 146/18639 0.0273972602739726 0.68544635469339 0.84013584204997 0.994425086832306 GO:0051539 4 iron, 4 sulfur cluster binding 1/745 45/18639 0.0222222222222222 0.555973154362416 0.840832219161465 0.994425086832306 GO:0140303 intramembrane lipid transporter activity 1/745 45/18639 0.0222222222222222 0.555973154362416 0.840832219161465 0.994425086832306 GO:0035401 histone H3Y41 kinase activity 3/745 115/18639 0.0260869565217391 0.652664137729793 0.843435273470402 0.994425086832306 GO:0140801 histone H2AXY142 kinase activity 3/745 115/18639 0.0260869565217391 0.652664137729793 0.843435273470402 0.994425086832306 GO:0004180 carboxypeptidase activity 1/745 46/18639 0.0217391304347826 0.543886781441494 0.847209545004464 0.994425086832306 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/745 46/18639 0.0217391304347826 0.543886781441494 0.847209545004464 0.994425086832306 GO:0015294 solute:monoatomic cation symporter activity 3/745 116/18639 0.0258620689655172 0.647037722749364 0.84760432455507 0.994425086832306 GO:0061749 forked DNA-dependent helicase activity 1/745 47/18639 0.0212765957446809 0.532314722261888 0.853331681774844 0.994425086832306 GO:0099095 ligand-gated monoatomic anion channel activity 1/745 47/18639 0.0212765957446809 0.532314722261888 0.853331681774844 0.994425086832306 GO:0140359 ABC-type transporter activity 1/745 47/18639 0.0212765957446809 0.532314722261888 0.853331681774844 0.994425086832306 GO:0140938 histone H3 methyltransferase activity 1/745 47/18639 0.0212765957446809 0.532314722261888 0.853331681774844 0.994425086832306 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/745 47/18639 0.0212765957446809 0.532314722261888 0.853331681774844 0.994425086832306 GO:0004527 exonuclease activity 2/745 84/18639 0.0238095238095238 0.59568552253116 0.85443655265854 0.994425086832306 GO:0000510 H3-H4 histone complex chaperone activity 4/745 151/18639 0.0264900662251656 0.662749455531357 0.858380226581134 0.994425086832306 GO:0140584 chromatin extrusion motor activity 4/745 151/18639 0.0264900662251656 0.662749455531357 0.858380226581134 0.994425086832306 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 4/745 151/18639 0.0264900662251656 0.662749455531357 0.858380226581134 0.994425086832306 GO:0140849 ATP-dependent H2AZ histone chaperone activity 4/745 151/18639 0.0264900662251656 0.662749455531357 0.858380226581134 0.994425086832306 GO:0009378 four-way junction helicase activity 1/745 48/18639 0.0208333333333333 0.521224832214765 0.859208827702003 0.994425086832306 GO:0036121 double-stranded DNA helicase activity 1/745 48/18639 0.0208333333333333 0.521224832214765 0.859208827702003 0.994425086832306 GO:0043138 3'-5' DNA helicase activity 1/745 48/18639 0.0208333333333333 0.521224832214765 0.859208827702003 0.994425086832306 GO:0015616 DNA translocase activity 4/745 152/18639 0.0263157894736842 0.658389261744966 0.86180844716558 0.994967972376578 GO:0140674 ATP-dependent histone chaperone activity 4/745 152/18639 0.0263157894736842 0.658389261744966 0.86180844716558 0.994967972376578 GO:0008237 metallopeptidase activity 5/745 184/18639 0.0271739130434783 0.679858476801868 0.863529697935134 0.995724367742488 GO:0061775 cohesin loader activity 4/745 153/18639 0.0261437908496732 0.654086063955784 0.86516551497587 0.996380506766292 GO:0015108 chloride transmembrane transporter activity 3/745 121/18639 0.0247933884297521 0.620300626767985 0.867030505450998 0.997298635580336 GO:0004386 helicase activity 4/745 155/18639 0.0258064516129032 0.645646243775709 0.871670341948125 0.999700918095069 GO:0005021 vascular endothelial growth factor receptor activity 1/745 51/18639 0.0196078431372549 0.490564547966838 0.875466293974664 0.999700918095069 GO:0005048 signal sequence binding 1/745 51/18639 0.0196078431372549 0.490564547966838 0.875466293974664 0.999700918095069 GO:0005272 sodium channel activity 1/745 51/18639 0.0196078431372549 0.490564547966838 0.875466293974664 0.999700918095069 GO:0003727 single-stranded RNA binding 2/745 89/18639 0.0224719101123595 0.562220043737275 0.875884893623995 0.999700918095069 GO:0004864 protein phosphatase inhibitor activity 1/745 53/18639 0.0188679245283019 0.47205267823224 0.885249031328946 0.999700918095069 GO:0008146 sulfotransferase activity 1/745 53/18639 0.0188679245283019 0.47205267823224 0.885249031328946 0.999700918095069 GO:0017046 peptide hormone binding 1/745 53/18639 0.0188679245283019 0.47205267823224 0.885249031328946 0.999700918095069 GO:0038064 collagen receptor activity 1/745 53/18639 0.0188679245283019 0.47205267823224 0.885249031328946 0.999700918095069 GO:0003689 DNA clamp loader activity 4/745 160/18639 0.025 0.625469798657718 0.88676000175842 0.999700918095069 GO:0052689 carboxylic ester hydrolase activity 2/745 92/18639 0.0217391304347826 0.543886781441494 0.887315699798275 0.999700918095069 GO:0017069 snRNA binding 1/745 54/18639 0.0185185185185185 0.46331096196868 0.889848701600114 0.999700918095069 GO:0016410 N-acyltransferase activity 2/745 94/18639 0.0212765957446809 0.532314722261888 0.894385835845433 0.999700918095069 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/745 130/18639 0.0230769230769231 0.577356737222509 0.896550439116354 0.999700918095069 GO:0140713 histone chaperone activity 4/745 164/18639 0.024390243902439 0.610214437714847 0.897694351131682 0.999700918095069 GO:0019212 phosphatase inhibitor activity 1/745 56/18639 0.0178571428571429 0.44676414189837 0.89850299806657 0.999700918095069 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/745 56/18639 0.0178571428571429 0.44676414189837 0.89850299806657 0.999700918095069 GO:0005262 calcium channel activity 3/745 131/18639 0.0229007633587786 0.572949433884933 0.899438043073702 0.999700918095069 GO:0017116 single-stranded DNA helicase activity 1/745 58/18639 0.0172413793103448 0.431358481832909 0.90647819003478 0.999700918095069 GO:0015297 antiporter activity 3/745 135/18639 0.0222222222222222 0.555973154362416 0.910275520622695 0.999700918095069 GO:0016779 nucleotidyltransferase activity 3/745 136/18639 0.0220588235294118 0.551885116462692 0.912814061525065 0.999700918095069 GO:0044325 transmembrane transporter binding 3/745 136/18639 0.0220588235294118 0.551885116462692 0.912814061525065 0.999700918095069 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/745 60/18639 0.0166666666666667 0.416979865771812 0.913827500995714 0.999700918095069 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/745 60/18639 0.0166666666666667 0.416979865771812 0.913827500995714 0.999700918095069 GO:0106310 protein serine kinase activity 10/745 361/18639 0.0277008310249307 0.693041328152596 0.915922920284113 0.999700918095069 GO:0008238 exopeptidase activity 2/745 102/18639 0.0196078431372549 0.490564547966838 0.918733501700624 0.999700918095069 GO:0140101 catalytic activity, acting on a tRNA 3/745 139/18639 0.0215827338129496 0.539973926898749 0.920042757759784 0.999700918095069 GO:0015179 L-amino acid transmembrane transporter activity 1/745 62/18639 0.0161290322580645 0.403528902359818 0.92059998832551 0.999700918095069 GO:1901682 sulfur compound transmembrane transporter activity 1/745 63/18639 0.0158730158730159 0.39712368168744 0.923784195070275 0.999700918095069 GO:0004518 nuclease activity 5/745 209/18639 0.0239234449760766 0.598535692495424 0.924223350142724 0.999700918095069 GO:0008094 ATP-dependent activity, acting on DNA 5/745 210/18639 0.0238095238095238 0.59568552253116 0.926055097535621 0.999700918095069 GO:0004536 DNA nuclease activity 1/745 64/18639 0.015625 0.390918624161074 0.926840868986761 0.999700918095069 GO:0008235 metalloexopeptidase activity 1/745 66/18639 0.0151515151515152 0.379072605247102 0.932591819798559 0.999700918095069 GO:0008194 UDP-glycosyltransferase activity 3/745 145/18639 0.0206896551724138 0.517630178199491 0.932882739156226 0.999700918095069 GO:0042393 histone binding 6/745 247/18639 0.0242914979757085 0.607743933918431 0.933142860355868 0.999700918095069 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4/745 181/18639 0.0220994475138122 0.552901479476436 0.934443387366841 0.999700918095069 GO:0004679 AMP-activated protein kinase activity 6/745 248/18639 0.0241935483870968 0.605293353539727 0.934681170395307 0.999700918095069 GO:0008173 RNA methyltransferase activity 1/745 67/18639 0.0149253731343284 0.373414805168787 0.935295696084031 0.999700918095069 GO:0042054 histone methyltransferase activity 1/745 67/18639 0.0149253731343284 0.373414805168787 0.935295696084031 0.999700918095069 GO:0140104 molecular carrier activity 6/745 249/18639 0.0240963855421687 0.60286245653756 0.936188047575214 0.999700918095069 GO:0015085 calcium ion transmembrane transporter activity 3/745 147/18639 0.0204081632653061 0.510587590740994 0.936722087758714 0.999700918095069 GO:0030145 manganese ion binding 1/745 68/18639 0.0147058823529412 0.367923410975128 0.937891254258562 0.999700918095069 GO:0008509 monoatomic anion transmembrane transporter activity 3/745 149/18639 0.0201342281879195 0.503734066033062 0.9403577707185 0.999700918095069 GO:0016279 protein-lysine N-methyltransferase activity 1/745 69/18639 0.0144927536231884 0.362591187627663 0.940382827979814 0.999700918095069 GO:0098960 postsynaptic neurotransmitter receptor activity 1/745 69/18639 0.0144927536231884 0.362591187627663 0.940382827979814 0.999700918095069 GO:0016278 lysine N-methyltransferase activity 1/745 70/18639 0.0142857142857143 0.357411313518696 0.942774577745837 0.999700918095069 GO:0140299 molecular sensor activity 1/745 71/18639 0.0140845070422535 0.352377351356461 0.94507049780504 0.999700918095069 GO:0140597 protein carrier chaperone 4/745 188/18639 0.0212765957446809 0.532314722261888 0.94573880572173 0.999700918095069 GO:0004521 RNA endonuclease activity 1/745 73/18639 0.0136986301369863 0.342723177346695 0.949390034091523 0.999700918095069 GO:0003678 DNA helicase activity 1/745 74/18639 0.0135135135135135 0.338091783058226 0.951420865967092 0.999700918095069 GO:0003684 damaged DNA binding 1/745 74/18639 0.0135135135135135 0.338091783058226 0.951420865967092 0.999700918095069 GO:0003724 RNA helicase activity 1/745 77/18639 0.012987012987013 0.324919375926087 0.957037942403981 0.999700918095069 GO:0016758 hexosyltransferase activity 4/745 197/18639 0.0203045685279188 0.507995775559568 0.957644038416834 0.999700918095069 GO:0016757 glycosyltransferase activity 6/745 267/18639 0.0224719101123595 0.562220043737275 0.958503170601134 0.999700918095069 GO:0008186 ATP-dependent activity, acting on RNA 1/745 79/18639 0.0126582278481013 0.316693568940617 0.960417454656193 0.999700918095069 GO:0000049 tRNA binding 1/745 80/18639 0.0125 0.312734899328859 0.962006301438582 0.999700918095069 GO:0015103 inorganic anion transmembrane transporter activity 3/745 165/18639 0.0181818181818182 0.454887126296522 0.963181923825077 0.999700918095069 GO:0004519 endonuclease activity 2/745 127/18639 0.015748031496063 0.393996723563917 0.965050810448407 0.999700918095069 GO:0031490 chromatin DNA binding 2/745 128/18639 0.015625 0.390918624161074 0.966233351090469 0.999700918095069 GO:0005244 voltage-gated monoatomic ion channel activity 3/745 173/18639 0.0173410404624277 0.433851883462001 0.971230951608707 0.999700918095069 GO:0022832 voltage-gated channel activity 3/745 175/18639 0.0171428571428571 0.428893576222435 0.972965839406614 0.999700918095069 GO:0004252 serine-type endopeptidase activity 3/745 176/18639 0.0170454545454545 0.42645668090299 0.973795647288426 0.999700918095069 GO:0042562 hormone binding 1/745 94/18639 0.0106382978723404 0.266157361130944 0.978594827155384 0.999700918095069 GO:0008276 protein methyltransferase activity 1/745 95/18639 0.0105263157894737 0.263355704697987 0.979454727601285 0.999700918095069 GO:0015276 ligand-gated monoatomic ion channel activity 3/745 186/18639 0.0161290322580645 0.403528902359818 0.980865814348164 0.999700918095069 GO:0030594 neurotransmitter receptor activity 1/745 97/18639 0.0103092783505155 0.257925690168131 0.981072411204707 0.999700918095069 GO:0005249 voltage-gated potassium channel activity 1/745 98/18639 0.0102040816326531 0.255293795370497 0.981832903797334 0.999700918095069 GO:0008170 N-methyltransferase activity 1/745 98/18639 0.0102040816326531 0.255293795370497 0.981832903797334 0.999700918095069 GO:0022834 ligand-gated channel activity 3/745 188/18639 0.0159574468085106 0.399236041696416 0.982042251021172 0.999700918095069 GO:0000287 magnesium ion binding 4/745 230/18639 0.0173913043478261 0.435109425153195 0.983568772659958 0.999700918095069 GO:0015171 amino acid transmembrane transporter activity 1/745 102/18639 0.00980392156862745 0.245282273983419 0.984581695997774 0.999700918095069 GO:0008236 serine-type peptidase activity 3/745 194/18639 0.0154639175257732 0.386888535252197 0.985170999852299 0.999700918095069 GO:0017171 serine hydrolase activity 3/745 198/18639 0.0151515151515152 0.379072605247102 0.986959028142444 0.999700918095069 GO:0016887 ATP hydrolysis activity 9/745 417/18639 0.0215827338129496 0.539973926898749 0.987018218159419 0.999700918095069 GO:0004843 cysteine-type deubiquitinase activity 1/745 108/18639 0.00925925925925926 0.23165548098434 0.98794592731284 0.999700918095069 GO:0140098 catalytic activity, acting on RNA 8/745 387/18639 0.020671834625323 0.517184329639457 0.988281836576044 0.999700918095069 GO:0022836 gated channel activity 6/745 318/18639 0.0188679245283019 0.47205267823224 0.988819510417124 0.999700918095069 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 4/745 243/18639 0.0164609053497942 0.411831966194382 0.988848337357394 0.999700918095069 GO:0141003 histone H2AX kinase activity 7/745 354/18639 0.019774011299435 0.494721874644523 0.988861844232288 0.999700918095069 GO:0004676 3-phosphoinositide-dependent protein kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0004711 ribosomal protein S6 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0035175 histone H3S10 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0035979 histone H2AXS139 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0044022 histone H3S28 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0044023 histone H4S1 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0044024 histone H2AS1 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0044025 histone H2BS14 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0072354 histone H3T3 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0072371 histone H2AS121 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0072518 Rho-dependent protein serine/threonine kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0140823 histone H2BS36 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0140855 histone H3S57 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0140995 histone H2A kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0140997 histone H4 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0140998 histone H2B kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:1990244 histone H2AT120 kinase activity 4/745 245/18639 0.0163265306122449 0.408470072592795 0.989500712113227 0.999700918095069 GO:0140996 histone H3 kinase activity 7/745 357/18639 0.0196078431372549 0.490564547966838 0.989690440766541 0.999700918095069 GO:0004677 DNA-dependent protein kinase activity 4/745 246/18639 0.016260162601626 0.406809625143231 0.989813085057519 0.999700918095069 GO:0140857 histone H3T45 kinase activity 4/745 246/18639 0.016260162601626 0.406809625143231 0.989813085057519 0.999700918095069 GO:0035402 histone H3T11 kinase activity 4/745 247/18639 0.0161943319838057 0.405162622612287 0.990116574503273 0.999700918095069 GO:0035403 histone H3T6 kinase activity 4/745 247/18639 0.0161943319838057 0.405162622612287 0.990116574503273 0.999700918095069 GO:0035173 histone kinase activity 7/745 360/18639 0.0194444444444444 0.486476510067114 0.990460887193702 0.999700918095069 GO:0101005 deubiquitinase activity 1/745 115/18639 0.00869565217391304 0.217554712576598 0.990955819743482 0.999700918095069 GO:0046982 protein heterodimerization activity 7/745 369/18639 0.018970189701897 0.47461122933377 0.992459866804559 0.999700918095069 GO:0140097 catalytic activity, acting on DNA 6/745 336/18639 0.0178571428571429 0.44676414189837 0.993155197582673 0.999700918095069 GO:0008528 G protein-coupled peptide receptor activity 1/745 122/18639 0.00819672131147541 0.205072065133678 0.993214896496104 0.999700918095069 GO:0005267 potassium channel activity 1/745 124/18639 0.00806451612903226 0.201764451179909 0.993749901672439 0.999700918095069 GO:0003730 mRNA 3'-UTR binding 4/745 262/18639 0.0152671755725191 0.381966289256622 0.993751226233723 0.999700918095069 GO:0005216 monoatomic ion channel activity 9/745 448/18639 0.0200892857142857 0.502609659635666 0.993859797706112 0.999700918095069 GO:0019783 ubiquitin-like protein peptidase activity 1/745 127/18639 0.0078740157480315 0.196998361781958 0.994474456101432 0.999700918095069 GO:0001653 peptide receptor activity 1/745 128/18639 0.0078125 0.195459312080537 0.994696827007031 0.999700918095069 GO:0099094 ligand-gated monoatomic cation channel activity 1/745 136/18639 0.00735294117647059 0.183961705487564 0.996182434870283 0.999700918095069 GO:0022843 voltage-gated monoatomic cation channel activity 1/745 143/18639 0.00699300699300699 0.174956587037124 0.997136948954118 0.999700918095069 GO:0046873 metal ion transmembrane transporter activity 8/745 450/18639 0.0177777777777778 0.444778523489933 0.99769108797567 0.999700918095069 GO:0008168 methyltransferase activity 2/745 204/18639 0.00980392156862745 0.245282273983419 0.997772989062844 0.999700918095069 GO:0005261 monoatomic cation channel activity 5/745 341/18639 0.0146627565982405 0.366844456690744 0.998084686930367 0.999700918095069 GO:0016741 transferase activity, transferring one-carbon groups 2/745 215/18639 0.00930232558139535 0.232732948337756 0.998516362016657 0.999700918095069 GO:0015079 potassium ion transmembrane transporter activity 1/745 160/18639 0.00625 0.15636744966443 0.998577146749746 0.999700918095069 GO:0015081 sodium ion transmembrane transporter activity 1/745 164/18639 0.00609756097560976 0.152553609428712 0.998793111524426 0.999700918095069 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/745 167/18639 0.00598802395209581 0.149813125426998 0.998933312901499 0.999700918095069 GO:0030371 translation repressor activity 4/745 329/18639 0.0121580547112462 0.304179841292507 0.999265711111167 0.999700918095069 GO:0045182 translation regulator activity 4/745 356/18639 0.0112359550561798 0.281110021868637 0.999700918095069 0.999700918095069