category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	128/1938	248/9376	2.49702053996471	ANXA2/S100A10/AHNAK/DYNLRB1/MYL12B/MYL12A/DYNLT1/ARPC2/NFKBIA/RRAS/RHOB/TXN/CYTH3/ACBD3/LY96/SNX9/CD14/TNFRSF1A/MYO6/ABI1/RAB9A/FOS/TUBA1A/ARPC5/MYL9/RAB5A/CASP4/ARPC3/CYTH2/TUBB2A/PTPRC/GCC2/TNFSF10/TCF7L1/IL18/IL1B/BIRC3/TRADD/FLNA/CASP1/DYNC1I2/ACTR3/PIK3CA/PLEKHM2/RAC1/RIPK2/CYFIP1/MAP2K3/ARL8B/RAB5C/NCKAP1L/TNF/MAPK3/RALA/DYNC1LI2/EXOC2/BAX/RELA/DCTN1/RAB5B/KPNA1/RAB7A/MYD88/DCTN6/FHOD1/ACTR10/ACTR1A/KPNA3/AHNAK2/ARL8A/CASP7/TAB3/NAIP/ACTB/GSDMD/KIF5B/DYNC1H1/PIK3CD/M6PR/RHOG/DYNLT3/VPS41/SNX33/PODXL/EXOC7/RIPK1/ARPC1B/TLR2/SKP1/BIRC2/FADD/ARPC5L/HSP90AA1/ARF6/MAP2K7/MAP2K4/CYTH4/TAB2/VPS11/CYTH1/TLR4/TUBA4A/ARF1/MAP3K7/IL6/PKN1/CASP8/STX10/PIK3C3/IKBKB/JUN/EXOC5/CHUK/RILP/PFN1/TLR5/PIK3C2B/TNFRSF10A/IKBKG/PIK3CB/MAPK1/NCKAP1/VPS39/NFKB1/NLRP3/IRAK4/MAPK8/PAK1	12.1955171538483
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	121/1938	250/9376	2.34158101135191	CLTB/LAPTM4A/CTSB/LGMN/CTSL/CTSD/HEXB/SLC17A5/VAMP8/CTSS/ASAH1/PSAP/IDS/LAPTM5/ACP5/CD63/SLC38A9/LAMP2/ATP6V0E1/CD68/ATP6V0D1/HEXA/ATP6V1D/SLC11A2/SLC15A3/CTSZ/GNS/TLR3/GNPTG/HGSNAT/LITAF/NAGLU/ARSG/ATP6V1E1/TPP1/SCARB2/MITF/CTSO/VPS35/TPCN1/ATP6V1G1/VPS13C/LIPA/CD164/CTSA/FUCA2/AP1M2/CTSH/SLC29A3/OSBPL2/MCOLN1/TCIRG1/NPC1/ARSA/SLC11A1/ARL8B/CLCN7/SMPD1/ROGDI/AP2A2/NEU1/PLA2G15/AP1S2/CTBS/ATP6AP1/LAMP1/ATP6V1H/ENTPD4/GPR155/ACP2/VAMP7/GNPTAB/RRAGD/CLTC/ATP6V1C1/RRAGC/PPT1/SUMF1/GAA/OSTM1/RAB7A/GUSB/AP1G1/ATP6V0B/AGA/ARL8A/DMXL2/SNAP29/STX17/IGF2R/NAGPA/BLOC1S6/M6PR/VPS41/LAMTOR3/OSBP/ABCA5/AP2B1/AP5S1/AP4E1/MANBA/GGA1/DTNBP1/VPS11/GALC/AP3S1/GGA2/TLR7/FIG4/AP5B1/LAMTOR5/RRAGA/SPG11/MFSD8/AP5Z1/VPS39/CLN5/GLB1/ARSB/TLR8/GALNS	10.9744082584636
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	118/1938	250/9376	2.28352528379773	CLTB/RAB11FIP1/TGFBR1/SH3KBP1/EGFR/HLA-B/FOLR1/NEDD4L/ARPC2/HLA-A/SH3GL1/CYTH3/HSPA1B/TSG101/ARFGAP3/CXCR4/CHMP5/PDCD6IP/SH3GLB1/IGF1R/ARPC5/AGAP3/RAB5A/ARPC3/CYTH2/ASAP2/FGFR2/HLA-F/SMAP1/VPS35/SMURF2/ARRB1/IST1/PIP5K1B/DNAJC6/PARD6B/RAB31/ARFGEF1/PLD1/ACTR3/CHMP4C/CHMP1A/VPS4B/CHMP1B/HSPA1A/EEA1/ASAP1/HLA-E/RAB5C/AP2A2/HSPA6/SNX2/DAB2/VPS28/ARRB2/VPS37B/RAB11A/MDM2/EHD4/ARAP2/ARAP1/VPS37A/CLTC/VTA1/NEDD4/GIT2/RAB11B/IL2RG/RAB5B/CAPZA2/RAB7A/CHMP2A/RABEP1/ARF4/GIT1/IGF2R/KIF5B/ARFGAP1/HGS/SMAD3/STAMBP/SMAD2/ARPC1B/TGFBR2/USP8/ARPC5L/AP2B1/ARF6/PARD3/CYTH4/PRKCI/CAPZA1/CYTH1/RAB35/ARF1/SMURF1/SH3GLB2/CHMP3/CAV2/RAB22A/EPS15/IQSEC1/PLD2/PIP5K1C/CHMP2B/CAPZB/SNX6/MVB12B/EPN2/VPS36/RAB10/VPS37C/WIPF1/STAM/RUFY1/FOLR2/VPS4A/SNX12	10.499500481348
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	70/1938	119/9376	2.8458689977539	IRF1/CXCL2/JUNB/NFKBIA/RHBDF1/CREB5/CXCL3/TNFRSF1A/CREB3L2/FOS/ICAM1/IL1B/BIRC3/CCL5/CFLAR/MAP3K5/SOCS3/TRADD/MMP9/JAG1/PIK3R1/PIK3CA/MAP2K3/MMP14/RPS6KA4/ATF4/TNF/MAPK3/TRAF3/RELA/CREB3/CCL20/XIAP/EDN1/ADAM17/PTGS2/CASP7/TAB3/CXCL10/TNFRSF1B/PIK3CD/BCL3/RIPK1/CEBPB/IFNB1/BIRC2/FADD/PIK3R3/MAP2K7/MAP2K4/TAB2/DNM1L/RHBDF2/MAP3K7/IL6/CASP8/IKBKB/JUN/CYLD/ATF6B/CHUK/IKBKG/PIK3CB/MAPK1/NFKB1/FAS/TNFAIP3/MAPK8/BAG4/DAB2IP	10.3436463142081
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	115/1938	253/9376	2.19908058917347	EGFR/CAST/CAPN2/MYL12B/MYL12A/ACTN4/WIPI1/ITGB1/SQSTM1/ARPC2/FNBP1L/UBC/NFKBIA/ITPR2/CYTH3/CD44/MAP1LC3B/CD14/TNFRSF1A/ARPC5/PTK2/MYL9/CASP4/ARPC3/CYTH2/IL18/IL1B/HCLS1/CCL5/PLCD3/TRADD/BCL2L1/ILK/CASP1/ACTR3/PIK3R1/PIK3CA/FOXO4/RAC1/GSK3B/RIPK2/UBE2D3/BCAR1/ARHGEF2/TNF/UBE2D1/CAPN1/MAPK3/MDM2/DIAPH1/FBXW11/ACTN1/TNIP1/RRAGD/BAX/CALCOCO2/RELA/RRAGC/BECN1/MYD88/TAB3/NAIP/CTTN/ACTB/NFKBIB/TBK1/WIPI2/SHARPIN/PIK3CD/C3/PXN/WASF2/UBE2D4/FOXO1/CAPNS1/RIPK1/ARPC1B/FOXO3/PLCB2/IFNB1/IRF3/SKP1/ARPC5L/VCL/HK3/PLCB1/BCL10/ARF6/PIK3R3/CYTH4/TAB2/CYTH1/TLR4/ARF1/MAP3K7/RBCK1/TLN1/ATG14/PIK3C3/IKBKB/JUN/CHUK/PFN1/TLR5/RRAGA/IKBKG/PIK3CB/MAPK1/CRK/NFKB1/NLRP3/FOXO6/RBX1/UBB/MAPK8	9.8690246414028
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	103/1938	216/9376	2.30699843290143	CXCL2/KRAS/ABCA1/NFE2L2/NFKBIA/ABCG1/HSPA1B/CCL3/LY96/CALM2/CXCL3/CD14/TNFRSF1A/NCF2/FOS/STAT3/RXRA/PTK2/ICAM1/CD36/VAV2/CYBB/RAP1B/TNFSF10/PDPK1/IL18/IL1B/CCL5/MAP3K5/MMP9/BCL2L1/CASP1/ATF6/PIK3R1/PIK3CA/RAC1/GSK3B/NCF4/NFATC2/HSPA1A/MAP2K3/ATF4/HSPA6/TNF/MAPK3/TRAF3/BAX/RELA/VLDLR/CD40/MIB1/HSPA2/RXRB/MYD88/VAV3/POU2F2/CAMK2D/CASP7/TBK1/VAV1/PIK3CD/PPP3CA/POU2F3/CASP9/PLCB2/IFNB1/BAD/TLR2/IRF3/OLR1/EIF2AK3/PLCB1/HSP90AA1/RAP1A/PIK3R3/MAP2K7/MAP2K4/TAB2/TLR4/SOD2/MAP3K7/IL6/CASP8/IKBKB/NFATC3/JUN/CHUK/TANK/TICAM1/TNFRSF10A/IKBKG/PIK3CB/MAPK1/IKBKE/XBP1/NFKB1/NLRP3/BID/FAS/IRAK4/MAPK8/CCL3L3/NRAS	9.91947399355084
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	99/1938	205/9376	2.33638903571698	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/GADD45A/JAK1/HLA-DPB1/CDKN1A/GADD45B/HLA-A/NFKBIA/VIM/HLA-DQA1/TAPBP/HLA-DMA/HLA-DQB1/HLA-DMB/CD44/STAT1/TAPBPL/CIR1/STAT3/ICAM1/HLA-F/HLA-DQA2/IFNAR1/TRADD/USP7/PIK3R1/PIK3CA/RAC1/SYK/MAP2K3/HLA-E/TAP1/TNF/MDM2/NFKB2/B2M/PSMD7/TRAF3/STAT2/BAX/CD58/NEDD4/RELA/BLNK/CD40/HES1/MYD88/BTK/HLA-DOA/RBPJ/NFKBIB/TBK1/CXCL10/RB1/PIK3CD/NFKBIE/ITGAL/RELB/OAS2/CASP9/RIPK1/IFNB1/TLR2/IRF3/FADD/PSMD8/HLA-DRB5/PIK3R3/MAP2K7/MAP2K4/TAB2/MAP3K7/IL6/ENTPD1/EIF2AK2/DDB2/CASP8/IKBKB/GADD45G/JUN/CHUK/OAS1/MAVS/SNW1/IKBKG/PIK3CB/IKBKE/BCL2L11/NFKB1/PSMD1/BID/PSMC6/FAS/TNFAIP3/IRAK4/MAPK8	9.87497318970007
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	66/1938	112/9376	2.85095090667846	HLA-DRA/LAMB4/HLA-DRB1/HLA-DPA1/BIRC7/JAK1/HLA-DPB1/ITGB1/IFNGR1/NFKBIA/ITGA6/HLA-DQA1/HLA-DMA/HLA-DQB1/HSPA1B/HLA-DMB/STAT1/LY96/TNFRSF1A/STAT3/HLA-DQA2/PDPK1/BIRC3/ALOX5/LAMA5/BCL2L1/LAMC2/LAMB3/LAMB2/HSPA1A/MAP2K3/HSPA6/TNF/GNAI2/MAPK3/LAMA3/RELA/CD40/LAMC1/MYD88/XIAP/IL10RB/HLA-DOA/TGFB2/NFKBIB/IL10/IFNGR2/CASP9/BAD/TLR2/BIRC2/PIK3R5/HLA-DRB5/SOCS1/CIITA/TAB2/TLR4/MAP3K7/CASP8/IKBKB/CHUK/IKBKG/MAPK1/NFKB1/IRAK4/MAPK8	10.0586356156708
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	90/1938	181/9376	2.40562406992457	HLA-DRA/CTSD/CD74/HLA-DRB1/HLA-DPA1/CTSS/JAK1/HLA-DPB1/FCER1G/LAMP2/IFNGR1/ITGB2/HLA-DQA1/FCGR3A/HLA-DMA/HLA-DQB1/HLA-DMB/ATP6V0D1/STAT1/LSP1/PLK3/CALM2/CD14/TNFRSF1A/RAB5A/HLA-DQA2/IL18/IL1B/FCGR1A/PLA2R1/TRADD/CREBBP/ITGAX/FCGR2A/SYK/RIPK2/TCIRG1/EEA1/RAB5C/TNF/MAPK3/ITGAM/ATP6AP1/LAMP1/ATP6V1H/CORO1A/BAX/RELA/KSR1/RAB5B/CLEC7A/RAB7A/CEBPG/MYD88/ATP6V0B/EP300/CAMK2D/IL10RB/HLA-DOA/IL1A/TGFB2/C3/IL10/PPP3CA/IFNGR2/CASP9/CEBPB/IFNB1/BAD/ARHGEF12/TLR2/FADD/BCL10/HLA-DRB5/CIITA/TLR4/TLR1/IL6/CASP8/PIK3C3/SPHK1/CARD9/MAPK1/NFKB1/CLEC4E/BID/IRAK4/MAPK8/VDR/NFYC	9.7469119675497
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	75/1938	138/9376	2.62933548705523	FN1/ITGB1/ARPC2/NFKBIA/BAIAP2/FOS/ARPC5/PTK2/ARPC3/CD4/VAV2/IL18/PIP5K1B/IL1B/CASP1/ACTR3/PIK3R1/PIK3CA/FCGR2A/RAC1/GSK3B/LCP2/GNAQ/NFATC2/BCAR1/MAP2K3/SKAP2/TNF/MAPK3/WAS/PKN2/GIT2/RELA/RAC2/MYD88/VAV3/ACTB/TBK1/VAV1/PIK3CD/IL10/PXN/WASF2/RHOG/ARPC1B/IFNB1/ARHGEF12/IRF3/ARPC5L/ARF6/PIK3R3/MAP2K7/MAP2K4/TAB2/TLR4/MAP3K7/IL6/PKN1/IKBKB/NFATC3/JUN/PIP5K1C/CHUK/TICAM1/IKBKG/PIK3CB/MAPK1/CRK/WIPF1/NFKB1/NLRP3/ARHGEF7/RPS6KA1/IRAK4/MAPK8	9.84227552163529
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	136/1938	333/9376	1.97587060744955	SPP1/FN1/ITGB6/ITGB4/LAMB4/EGFR/HLA-B/IRF1/WNT6/JAK1/CDKN1A/KRAS/ITGB1/HES2/HLA-A/ITGA2/ATP6V0E1/ITGA6/BCAP31/FZD5/ATP6V0D1/CREB5/STAT1/MAML2/WNT10A/ITGA3/ATP6V1D/CRB3/TNFRSF1A/TLR3/CREB3L2/SOS1/PTK2/WNT7A/ATP6V1E1/WNT11/HLA-F/TCF7L1/ATP6V1G1/IFNAR1/PARD6B/LAMA5/TRADD/PPP2R3A/LLGL2/CREBBP/NOTCH3/LAMC2/JAG1/PIK3R1/LAMB3/PIK3CA/LAMB2/GSK3B/TCIRG1/SOS2/UBR4/HLA-E/NOTCH2/PTGER4/PPP2R2A/COL4A5/TNF/MAPK3/ATP6AP1/PPP2R2B/MDM2/RHEB/ATP6V1H/PPP2R5E/LAMA3/TRAF3/STAT2/OASL/BAX/ATP6V1C1/NOTCH1/RELA/CREB3/LAMC1/HES1/ATP6V0B/RBL2/PPP2CB/EP300/LFNG/CSNK1A1/PTGS2/RBPJ/TBK1/PPP2CA/RB1/PIK3CD/THBS1/COL4A2/PXN/VEGFA/EIF4EBP1/FZD1/FOXO1/IFNB1/BAD/TSC2/MX2/IRF3/FADD/UBE3A/TSC1/THBS3/FZD6/PARD3/PIK3R3/PRKCI/PSEN1/MFNG/EIF2AK2/CASP8/IKBKB/CHUK/HES4/TICAM1/WNT5A/IKBKG/TADA3/PIK3CB/MAPK1/IKBKE/DVL3/NFKB1/PRKACB/PPP2R3C/TBP/ITGB3/FAS/WNT9A/NRAS	9.25534317532457
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	88/1938	180/9376	2.36523334479991	HLA-DRA/CD74/HLA-DRB1/HLA-B/HLA-DPA1/JAK1/HLA-DPB1/HLA-A/IFNGR1/NFKBIA/SP100/HLA-DQA1/TAPBP/HLA-DMA/HLA-DQB1/HLA-DMB/STAT1/TAPBPL/TNFRSF1A/TLR3/IFIH1/HLA-F/HLA-DQA2/IFNAR1/IL1B/BIRC3/CCL5/SOCS3/TRADD/BCL2L1/TNFRSF14/PIK3R1/PIK3CA/SYK/PILRA/BST2/HLA-E/TAP1/TNF/RHEB/B2M/TRAF3/STAT2/BAX/RELA/RNASEL/MYD88/DAXX/POU2F2/HLA-DOA/TBK1/PIK3CD/C3/IFNGR2/POU2F3/EIF4EBP1/OAS2/CASP9/IFNB1/BAD/TLR2/TSC2/IRF3/BIRC2/FADD/TSC1/HLA-DRB5/PIK3R3/TAB2/MAP3K7/IL6/EIF2AK2/CASP8/IKBKB/ZC3HAV1/CHUK/TICAM1/OAS1/MAVS/CARD9/IKBKG/PIK3CB/IKBKE/NFKB1/BID/ITGB3/FAS/IRAK4	9.44013262676315
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	84/1938	173/9376	2.34907568138299	HLA-DRA/HLA-DRB1/HLA-DPA1/JAK1/HLA-DPB1/IFNGR1/NFKBIA/HLA-DQA1/HLA-DMA/HLA-DQB1/DNAJB1/HLA-DMB/STAT1/TNFRSF1A/TLR3/IFIH1/ICAM1/HLA-DQA2/TNFSF10/IL18/IFNAR1/IL1B/CCL5/SOCS3/TRADD/CREBBP/CASP1/PIK3R1/PIK3CA/KPNA6/TNF/MAPK3/RAB11A/TRAF3/STAT2/BAX/CALCOCO2/ADAR/RELA/RAB11B/KPNA1/RNASEL/MYD88/EP300/HLA-DOA/IL1A/ACTB/NFKBIB/TBK1/CXCL10/PIK3CD/IFNGR2/OAS2/CASP9/IFNB1/MX2/IRF3/FADD/HLA-DRB5/PIK3R3/PRKCB/CIITA/TLR4/IL6/HNRNPUL1/EIF2AK2/CASP8/TLR7/IKBKB/CHUK/TICAM1/OAS1/MAVS/TNFRSF10A/IKBKG/PIK3CB/MAPK1/IKBKE/NXT1/NFKB1/NLRP3/BID/FAS/IRAK4	9.14174476637046
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	88/1938	187/9376	2.27669519820312	CTSB/GBP2/JAK1/CXCL2/GBP3/NFKBIA/GBP1/GABARAPL2/ITPR2/TXN/GABARAPL1/IFI16/STAT1/CXCL3/MAP1LC3B/GABARAP/CASP4/GPSM3/CYBB/IL18/IFNAR1/IL1B/BIRC3/CCL5/BCL2L1/CASP1/RIPK2/TXNIP/TNF/CARD16/MAPK3/TRAF3/STAT2/PKN2/RELA/MFN2/RNASEL/MYD88/MCU/NAMPT/XIAP/NEK7/TAB3/NAIP/GSDMD/NFKBIB/TBK1/SHARPIN/GBP4/OAS2/RIPK1/CARD6/PLCB2/IFNB1/NLRP7/IRF3/BIRC2/FADD/PLCB1/HSP90AA1/P2RX7/PSTPIP1/TAB2/DNM1L/GBP5/TLR4/MAP3K7/RBCK1/IL6/PKN1/CASP8/IKBKB/JUN/CHUK/TANK/TICAM1/OAS1/MAVS/PANX1/CARD9/IKBKG/MAPK1/IKBKE/NFKB1/NLRP3/TNFAIP3/IRAK4/MAPK8	9.00136432771544
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	82/1938	169/9376	2.34742093660884	CTSB/CTSL/CTSD/VAMP8/WIPI1/KRAS/SQSTM1/STX7/LAMP2/ATG9B/UBC/GABARAPL2/RRAS/GABARAPL1/MRAS/MAP1LC3B/IRS2/SH3GLB1/GABARAP/IGF1R/EIF2AK4/PDPK1/ULK1/CFLAR/BCL2L1/DAPK1/PIK3R1/PIK3CA/RAB1A/OPTN/RRAS2/MAPK3/LAMP1/RHEB/HIF1A/RB1CC1/RRAGD/CALCOCO2/RRAGC/RAB7A/BECN1/VMP1/WDR45/PPP2CB/SNAP29/TAX1BP1/STX17/TBK1/ATG3/WIPI2/PPP2CA/PIK3CD/ATG4D/VPS41/NBR1/DAPK3/GORASP2/BAD/TSC2/BIRC6/CAMKK2/TSC1/EIF2AK3/UVRAG/PIK3R3/VPS11/MAP3K7/ATG14/PIK3C3/ULK2/TANK/RRAGA/MTMR14/PIK3CB/STK11/MAPK1/VPS39/PRKACB/UBB/MAPK8/EPG5/NRAS	9.02239859338879
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	80/1938	163/9376	2.37446738462902	TGFBR1/JAK1/CDKN1A/KRAS/NFKBIA/CREB5/STAT1/TLR3/CREB3L2/FOS/STAT3/SOS1/SMAD4/IFIH1/IFNAR1/MMP9/YWHAZ/CREBBP/PIK3R1/PIK3CA/STAT6/NFATC2/SOS2/MAP2K3/ATF4/TNF/STAT4/MAPK3/ATP6AP1/TRAF3/STAT2/BAX/RELA/CREB3/MYD88/EP300/TGFB2/TBK1/STAT5B/SMAD3/RB1/PIK3CD/STAT5A/CASP9/IFNB1/BAD/TLR2/IRF3/TGFBR2/FADD/PIK3R3/PRKCB/MAP2K7/MAP2K4/TAB2/MAP3K1/TLR4/MAP3K7/IL6/DDB2/CASP8/IKBKB/NFATC3/JUN/ATF6B/CHUK/TICAM1/MAVS/ARAF/IKBKG/PIK3CB/MAPK1/IKBKE/NFKB1/BID/FAS/EGR2/IRAK4/MAPK8/NRAS	9.03570706746351
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	91/1938	200/9376	2.20127966976264	TJP1/ITGB1/ARPC2/NFKBIA/CYTH3/CLDN4/BAIAP2/MYH9/TNFRSF1A/MYO6/ABI1/FOS/TUBA1A/ARPC5/CASP4/ARPC3/CYTH2/TUBB2A/PAK2/TNFSF10/IL18/IL1B/HCLS1/EZR/MYO5B/TRADD/CLDN19/CASP1/CLDN23/ACTR3/PTPN6/FCGR2A/RAB1A/RAC1/CYFIP1/MYO1C/ARHGEF2/NCKAP1L/TNF/MAPK3/GNA13/BAX/RELA/CLDN7/MYD88/MYO5A/CASP7/TAB3/NAIP/CTTN/ACTB/NFKBIB/SEC24D/WASF2/CLDN1/CASP9/RIPK1/ARPC1B/ARHGEF12/FADD/ARPC5L/ARF6/CYTH4/TAB2/CYTH1/NCK1/TLR4/TUBA4A/ARF1/MAP3K7/IL6/CASP8/IKBKB/JUN/CHUK/TLR5/TNFRSF10A/IKBKG/NCK2/MAPK1/NCKAP1/WIPF1/NFKB1/NLRP3/MYO5C/MYO1G/FAS/MYO1D/IRAK4/MAPK8/PAK1	8.76530152092071
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	70/1938	137/9376	2.47195920242857	CTSB/CTSL/CTSD/CAPN2/CTSS/PMAIP1/GADD45A/KRAS/GADD45B/LMNA/NFKBIA/ITPR2/BCL2A1/MCL1/CTSZ/TNFRSF1A/FOS/TUBA1A/CTSO/TNFSF10/PDPK1/CSF2RB/BIRC3/CFLAR/MAP3K5/TRADD/BCL2L1/PIK3R1/PIK3CA/CTSH/PARP4/BBC3/NOL3/ATF4/TNF/CAPN1/MAPK3/BAX/RELA/DAXX/XIAP/SPTAN1/CASP7/ACTB/PIK3CD/CASP9/RIPK1/BAD/BIRC2/FADD/EIF2AK3/PIK3R3/TUBA4A/CASP8/IKBKB/GADD45G/JUN/CHUK/TNFRSF10A/IKBKG/PIK3CB/MAPK1/BCL2L11/NFKB1/HRK/BID/FAS/MAPK8/NRAS/DAB2IP	8.85886351249445
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	60/1938	109/9376	2.66310676854035	SPP1/JAK1/NFKBIA/STAT1/CCL3/LY96/CD14/TLR3/FOS/IFNAR1/IL1B/CCL5/CD86/PIK3R1/PIK3CA/RAC1/MAP2K3/TNF/MAPK3/TRAF3/STAT2/RELA/CD40/MYD88/CCL4/CXCL9/TBK1/CXCL10/PIK3CD/RIPK1/IFNB1/TLR2/IRF3/IRF5/FADD/PIK3R3/MAP2K7/MAP2K4/TAB2/TLR4/MAP3K7/TLR1/IL6/CASP8/TLR7/IKBKB/JUN/CHUK/TLR5/TICAM1/IKBKG/PIK3CB/MAPK1/IKBKE/NFKB1/TOLLIP/TLR8/IRAK4/MAPK8/CCL3L3	8.91452559133778
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	57/1938	103/9376	2.67732724157624	SERPINE1/TGFBR1/IFNGR1/NFKBIA/C1QA/C1QB/CCL3/TNFRSF1A/FOS/BDKRB2/IL1B/CCL5/GNA11/CFLAR/C1QC/PIK3R1/PIK3CA/GNAQ/PPP2R2A/TNF/GNAI2/MAPK3/PPP2R2B/RELA/MYD88/PPP2CB/GNA15/TGFB2/PPP2CA/PIK3CD/C3/IL10/IFNGR2/SMAD2/PLCB2/IFNB1/TLR2/TGFBR2/FADD/PLCB1/PIK3R3/MAP2K4/TLR4/IL6/CASP8/IKBKB/JUN/CHUK/TICAM1/IKBKG/PIK3CB/MAPK1/NFKB1/FAS/IRAK4/MAPK8/CCL3L3	8.73696750465576
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	70/1938	142/9376	2.38491838544165	TGFBR1/TYROBP/JAK1/ACP5/JUNB/SQSTM1/JUND/IFNGR1/NFKBIA/FCGR3A/CSF1R/ITPR2/TREM2/STAT1/TNFRSF1A/NCF2/SPI1/FOSL2/FOS/MITF/LILRB4/FHL2/IFNAR1/IL1B/FCGR1A/SOCS3/PIK3R1/PIK3CA/FCGR2A/RAC1/NCF4/SYK/LCP2/NFATC2/TNF/MAPK3/NFKB2/OSCAR/STAT2/RELA/BLNK/BTK/FOSB/IL1A/TGFB2/LILRB2/PIK3CD/PPP3CA/IFNGR2/LILRB1/RELB/LILRB3/IFNB1/TGFBR2/LILRA2/SOCS1/PIK3R3/MAP2K7/TAB2/MAP3K7/IKBKB/JUN/CYLD/CHUK/IKBKG/PIK3CB/MAPK1/NFKB1/ITGB3/MAPK8	8.48804855813389
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	90/1938	204/9376	2.13440174831543	TIMP3/FN1/IGF2/CTSL/EGFR/PLAU/WNT6/CDKN1A/KRAS/ITGB1/CD63/ITGA2/RRAS/ITPR2/MET/FZD5/CD44/ERBB3/SDC4/WNT10A/MRAS/PPP1R12B/PLAUR/IGF1R/STAT3/SOS1/PTK2/WNT7A/RDX/WNT11/VAV2/PDPK1/HCLS1/TIAM1/PDCD4/EZR/FRS2/MMP9/FLNA/PIK3R1/PIK3CA/PTPN6/RAC1/SOS2/RRAS2/GAB1/TNF/MAPK3/MDM2/HIF1A/HBEGF/PPP1R12A/IQGAP1/SDC2/VAV3/PPP1R12C/CAMK2D/CTTN/TGFB2/ACTB/VAV1/PIK3CD/THBS1/PXN/VEGFA/SMAD2/FZD1/ARHGEF12/TLR2/DDX5/FZD6/GPC1/PIK3R3/PRKCB/HPSE/TLR4/CAV2/MSN/WNT5A/SDC1/ARAF/PIK3CB/MAPK1/PRKACB/SLC9A1/ITGB3/FAS/WNT9A/PAK1/NRAS	8.36150368300407
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	47/1938	78/9376	2.91519144769919	HLA-DRA/HLA-DRB1/HLA-DPA1/JAK1/HLA-DPB1/ITGB1/IFNGR1/NFKBIA/ITGB2/HLA-DQA1/FCGR3A/HLA-DMA/HLA-DQB1/HLA-DMB/STAT1/NCF2/FOS/HLA-DQA2/CYBB/IL1B/FCGR1A/PTPN6/FCGR2A/NCF4/TNF/MAPK3/ITGAM/RELA/MYD88/PTGS2/HLA-DOA/IL1A/TGFB2/NFKBIB/C3/IL10/IFNGR2/TLR2/HLA-DRB5/PRKCB/TAB2/TLR4/MAP3K7/JUN/MAPK1/NFKB1/IRAK4	8.66960202278767
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	74/1938	155/9376	2.30974399946736	HLA-DRA/CTSL/HLA-DRB1/HLA-B/HLA-DPA1/CTSS/HLA-DPB1/ITGB1/STX7/LAMP2/HLA-A/ITGA2/ATP6V0E1/ITGB2/HLA-DQA1/FCGR3A/HLA-DMA/HLA-DQB1/HLA-DMB/MSR1/ATP6V0D1/ATP6V1D/CD14/NCF2/TUBA1A/ATP6V1E1/RAB5A/TUBB2A/HLA-F/CD36/HLA-DQA2/CYBB/ATP6V1G1/FCGR1A/PLA2R1/DYNC1I2/FCGR2A/RAC1/NCF4/TCIRG1/EEA1/HLA-E/TAP1/RAB5C/ITGAM/ATP6AP1/LAMP1/ATP6V1H/DYNC1LI2/CORO1A/STX12/MARCO/ATP6V1C1/RAB5B/CLEC7A/RAB7A/ATP6V0B/HLA-DOA/ACTB/HGS/DYNC1H1/C3/THBS1/STX18/M6PR/TLR2/OLR1/THBS3/HLA-DRB5/TLR4/TUBA4A/PIK3C3/RILP/ITGB3	8.39262257824431
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	87/1938	196/9376	2.14746951412144	IL6ST/HLA-B/JAK1/RCAN1/CDKN1A/CXCL2/KRAS/ZFP36/HLA-A/UBC/IFNGR1/NFKBIA/ITPR2/STAT1/CALM2/CXCL3/MAP1LC3B/TNFRSF1A/TLR3/FOS/STAT3/PDGFB/ICAM1/HLA-F/CLEC2B/TCF7L1/IFNAR1/TRADD/CREBBP/CD86/PIK3R1/PIK3CA/RAC1/GSK3B/SYK/NFATC2/HLA-E/HCK/MAPK3/HIF1A/TRAF3/STAT2/BAX/RELA/BECN1/EP300/PTGS2/TBK1/ATG3/RB1/PIK3CD/C3/PPP3CA/VEGFA/CASP9/IFNB1/IRF3/PREX1/FADD/PIK3R5/PIK3R3/MAPKAPK2/MAP2K7/MAP2K4/CCR1/IL6/EIF2AK2/CASP8/ATG14/PIK3C3/IKBKB/NFATC3/JUN/CHUK/TICAM1/GNB1/IKBKG/PIK3CB/MAPK1/IKBKE/NFKB1/BID/FAS/GNB4/UBB/MAPK8/NRAS	8.28671282502765
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	58/1938	109/9376	2.57433654292234	HLA-DRA/IL6ST/TGFBR1/HLA-DRB1/HLA-DPA1/JAK1/HLA-DPB1/IL1RAP/GATA3/IFNGR1/NFKBIA/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/RUNX1/STAT1/FOS/STAT3/RXRA/SMAD4/EBI3/CD4/HLA-DQA2/IL1B/STAT6/NFATC2/IL4R/AHR/MAPK3/HIF1A/IL6R/RELA/IL2RG/RXRB/HLA-DOA/NFKBIB/STAT5B/SMAD3/STAT5A/PPP3CA/IFNGR2/NFKBIE/SMAD2/TGFBR2/IL27/HSP90AA1/HLA-DRB5/IL6/IKBKB/NFATC3/JUN/IL27RA/CHUK/IKBKG/MAPK1/NFKB1/MAPK8	8.43870259368675
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	95/1938	227/9376	2.02470415478967	EGFR/HLA-B/JAK1/CDKN1A/AKAP13/KRAS/HLA-A/NFKBIA/TAPBP/ITPR2/CREB5/TAPBPL/CCL3/CALM2/CXCR4/TNFRSF1A/CDKN2A/CREB3L2/STAT3/SOS1/PTK2/HLA-F/IL1B/CCL5/GNA11/TRADD/PIK3R1/PIK3CA/RAC1/GSK3B/GNAQ/NFATC2/SOS2/BCAR1/HLA-E/TAP1/PTGER4/ATF4/TNF/GNAI2/MAPK3/MDM2/RHEB/B2M/IL6R/GNA13/BAX/RELA/CREB3/RAC2/CCL4/PTGS2/IL10RB/TBK1/RB1/PIK3CD/PPP3CA/PXN/VEGFA/EIF4EBP1/CASP9/RIPK1/PLCB2/IFNB1/ARHGEF12/TSC2/IRF3/FADD/TSC1/PLCB1/PIK3R3/PRKCB/ADCY9/CCR1/IL6/CASP8/ADCY7/IKBKB/NFATC3/ATF6B/CHUK/GNB1/IKBKG/PIK3CB/MAPK1/CRK/NFKB1/PRKACB/BID/ITGB3/SP1/FAS/GNB4/CCL3L3/NRAS	7.97735739618821
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	65/1938	133/9376	2.36442499437448	TGFBR1/EGFR/GADD45A/CDKN1A/KRAS/GADD45B/PRKAB2/FBXO32/GABARAPL2/HOMER3/GABARAPL1/PLK3/IRS2/GABARAP/IGF1R/STAT3/SOS1/SMAD4/TNFSF10/PDPK1/CDKN2B/PRKAG2/CREBBP/USP7/PIK3R1/PIK3CA/PLK2/FOXO4/SOS2/MAPK3/CCNG2/MDM2/INSR/SGK1/BCL6/STK4/RBL2/EP300/TGFB2/SMAD3/PIK3CD/IL10/KLF2/FOXO1/FOXO3/TGFBR2/IL7R/PIK3R3/CSNK1E/SOD2/IL6/SETD7/IKBKB/GADD45G/CHUK/ARAF/PIK3CB/STK11/MAPK1/S1PR4/BCL2L11/FOXO6/CDKN2D/MAPK8/NRAS	8.08916041607626
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	55/1938	105/9376	2.53417858371419	IRF1/KRAS/FCER1G/NFKBIA/RRAS/ITPR2/STAT1/LSP1/PLK3/MRAS/CALM2/IL1B/CASP1/PIK3R1/PIK3CA/SYK/NFATC2/RRAS2/TNF/MAPK3/MDM2/NFKB2/STAT2/RELA/KSR1/CLEC7A/PTGS2/PIK3CD/BCL3/IL10/PPP3CA/RELB/ARHGEF12/BCL10/PIK3R3/MAPKAPK2/IL6/CASP8/IKBKB/NFATC3/JUN/CYLD/CHUK/CARD9/IKBKG/PIK3CB/MAPK1/IKBKE/NFKB1/NLRP3/CLEC4E/EGR2/MAPK8/PAK1/NRAS	8.06940870523083
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	93/1938	224/9376	2.00862450243255	HLA-DRA/TGFBR1/HLA-DRB1/HLA-B/HLA-DPA1/JAK1/HLA-DPB1/CDKN1A/KRAS/ZFP36/HLA-A/NFKBIA/ITGB2/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/CREB5/TNFRSF1A/SPI1/CDKN2A/CREB3L2/FOS/SMAD4/ICAM1/CD4/HLA-F/ETS2/HLA-DQA2/CDKN2B/BCL2L1/CREBBP/PIK3R1/PIK3CA/NFATC2/HLA-E/ATF4/TNF/NRP1/MAPK3/ANAPC13/NFKB2/B2M/BAX/RELA/IL2RG/CREB3/CD40/EP300/XIAP/HLA-DOA/TGFB2/STAT5B/SMAD3/RB1/PIK3CD/STAT5A/PPP3CA/ITGAL/ELK4/SMAD2/MMP7/RELB/TGFBR2/HLA-DRB5/PIK3R3/MAP2K4/ADCY9/MAP3K1/LTBR/IL6/TLN1/VAC14/ADCY7/IKBKB/NFATC3/JUN/ATF6B/CHUK/KAT5/KAT2B/IKBKG/PIK3CB/MAPK1/NFKB1/PRKACB/MAD1L1/CRTC2/TBP/IL15RA/EGR2/MAPK8/NRAS	7.79883900725805
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	115/1938	300/9376	1.85455796353629	IGF2/TGFBR1/HSPB1/EGFR/PDGFA/EFNA1/DUSP1/GADD45A/IL1RAP/KRAS/GADD45B/JUND/RASA1/CSF1R/RRAS/MET/HSPA1B/FLT1/ERBB3/MRAS/CD14/TNFRSF1A/IGF1R/FOS/DUSP2/SOS1/PDGFB/DUSP3/FGFR2/PAK2/RAP1B/RAPGEF2/ARRB1/IL1B/MAP3K5/TRADD/FLNA/TAOK3/EREG/RASGRF2/DUSP10/RAC1/FGF1/SOS2/RRAS2/HSPA1A/MAP2K3/STK3/RPS6KA4/CACNG4/ATF4/HSPA6/RASA2/TNF/CACNA2D3/ARRB2/MAPK3/MAPKAPK3/NFKB2/INSR/MAP3K2/RELA/EFNA5/RAC2/MYD88/STK4/EPHA2/DAXX/PPM1A/IL1A/TGFB2/TAOK1/MAX/MAPK8IP3/PPP3CA/RASGRP3/VEGFA/ELK4/RELB/LAMTOR3/TGFBR2/DUSP8/MAP4K3/RAP1A/PRKCB/MAPKAPK2/MAP2K7/MAP2K4/TAB2/BDNF/MAP3K1/NTF4/MAP3K7/IKBKB/NFATC3/GADD45G/AREG/MAP4K4/JUN/MAP3K6/CHUK/MAP3K11/PPM1B/ARAF/IKBKG/MAPK1/CRK/NFKB1/PRKACB/RPS6KA1/FAS/IRAK4/MAPK8/PAK1/NRAS	7.67872911256606
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	95/1938	232/9376	1.98106828938472	FN1/GSN/ITGB6/ITGB4/EGFR/PDGFA/MYL12B/TMSB4X/IQGAP2/MYL12A/ACTN4/KRAS/ITGB1/ARPC2/ITGA2/RGCC/ITGA6/ITGB2/RRAS/LIMK2/SCIN/ITGA3/BAIAP2/MRAS/MYH9/PPP1R12B/CXCR4/SOS1/ARPC5/PTK2/MYL9/PDGFB/ARPC3/RDX/FGFR2/PAK2/SSH3/VAV2/BDKRB2/PIP5K1B/TIAM1/EZR/ACTR3/ITGAX/PIK3R1/PIK3CA/RAC1/FGF1/DIAPH2/CYFIP1/SOS2/RRAS2/BCAR1/PIP4K2A/NCKAP1L/MAPK3/ITGAM/SSH2/DIAPH1/ACTN1/GNA13/PPP1R12A/IQGAP1/RAC2/VAV3/GIT1/PPP1R12C/ACTB/VAV1/PIK3CD/PXN/WASF2/ITGAL/SSH1/ARPC1B/ARHGEF12/ARPC5L/VCL/PIK3R3/CFL2/MSN/PIP5K1C/PFN1/ARAF/PIK3CB/FGD3/MAPK1/CRK/NCKAP1/ARHGEF7/SLC9A1/ITGB3/PIP4K2C/PAK1/NRAS	7.72341835144518
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	71/1938	156/9376	2.20189992326215	EGFR/JAK1/CDKN1A/KRAS/NFKBIA/CLDN4/STAT1/TNFRSF1A/TLR3/STAT3/SOS1/RXRA/IFNAR1/CD81/CFLAR/SOCS3/TRADD/YWHAZ/CLDN19/CLDN23/PIK3R1/PIK3CA/GSK3B/SOS2/PIAS1/IFIT1/PPP2R2A/TNF/MAPK3/PPP2R2B/TRAF3/STAT2/BAX/RELA/CLDN7/RNASEL/PPP2CB/TBK1/CXCL10/YWHAH/PPP2CA/RB1/PIK3CD/YWHAG/OAS2/CLDN1/CASP9/RIPK1/IFNB1/BAD/MX2/IRF3/FADD/PIK3R3/EIF2AK2/CASP8/IKBKB/CHUK/TICAM1/OAS1/MAVS/ARAF/PPARA/IKBKG/PIK3CB/MAPK1/IKBKE/NFKB1/BID/FAS/NRAS	7.72679844329019
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	49/1938	91/9376	2.60506469794396	DAPP1/KRAS/NFKBIA/INPPL1/FOS/SOS1/LILRB4/VAV2/CD81/PIK3R1/PIK3CA/PTPN6/RAC1/GSK3B/SYK/NFATC2/SOS2/MAPK3/PIK3AP1/RELA/CD72/BLNK/RAC2/BTK/VAV3/NFKBIB/VAV1/LILRB2/PIK3CD/PPP3CA/LILRB1/RASGRP3/NFKBIE/LILRB3/INPP5D/CD22/LILRA2/BCL10/PIK3R3/PRKCB/IKBKB/NFATC3/JUN/CHUK/IKBKG/PIK3CB/MAPK1/NFKB1/NRAS	7.85338199797481
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	53/1938	105/9376	2.44202663521549	PINK1/KRAS/SQSTM1/ATG9B/UBC/GABARAPL2/RRAS/GABARAPL1/MRAS/MAP1LC3B/GABARAP/CITED2/RAB5A/MITF/ULK1/SMURF2/BCL2L1/OPTN/BNIP3L/AMFR/RRAS2/RAB5C/ATF4/HIF1A/CSNK2B/CALCOCO2/USP15/RELA/FIS1/MFN2/RAB5B/RAB7A/BECN1/TAX1BP1/TBK1/NBR1/FOXO3/TBC1D15/USP8/RHOT2/EIF2AK3/MON1B/SMURF1/CCZ1B/JUN/RHOT1/MUL1/SP1/FUNDC1/TBC1D17/UBB/MAPK8/NRAS	7.58471171929121
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	84/1938	203/9376	2.0019216397993	SPP1/FN1/ITGB6/ITGB4/LAMB4/EGFR/PDGFA/CAPN2/MYL12B/MYL12A/ACTN4/ITGB1/ZYX/ITGA2/ITGA6/MET/FLT1/ITGA3/PPP1R12B/IGF1R/SOS1/PTK2/MYL9/PDGFB/PAK2/VAV2/RAP1B/PDPK1/PIP5K1B/BIRC3/LAMA5/FLNA/ILK/LAMC2/PIK3R1/LAMB3/PIK3CA/LAMB2/VASP/RAC1/GSK3B/FLNB/SOS2/BCAR1/COL4A5/PARVG/RAPGEF1/MAPK3/DIAPH1/ACTN1/LAMA3/PPP1R12A/LAMC1/RAC2/VAV3/XIAP/PPP1R12C/ACTB/VAV1/PIK3CD/THBS1/COL4A2/PXN/VEGFA/BAD/BIRC2/VCL/THBS3/RAP1A/PIK3R3/PRKCB/TLN1/CAV2/PARVB/JUN/PIP5K1C/SHC1/EMP1/PIK3CB/MAPK1/CRK/ITGB3/MAPK8/PAK1	7.36648852163492
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	43/1938	77/9376	2.70172758098455	TGFBR1/EGFR/GADD45A/JAK1/CDKN1A/KRAS/GADD45B/STAT1/RALGDS/CDKN2A/STAT3/SMAD4/PLD1/BCL2L1/PIK3R1/PIK3CA/RAC1/MAPK3/RALA/BAX/RELA/RAC2/TGFB2/SMAD3/RB1/PIK3CD/VEGFA/SMAD2/CASP9/BAD/TGFBR2/PIK3R3/DDB2/IKBKB/GADD45G/PLD2/CHUK/ARAF/IKBKG/PIK3CB/MAPK1/NFKB1/MAPK8	7.65335245499018
Human Diseases	Infectious disease: viral	hsa05162	Measles	63/1938	136/9376	2.2411218357312	JAK1/NFKBIA/HSPA1B/STAT1/RAB9A/FOS/STAT3/IFIH1/IFNAR1/IL1B/TRADD/BCL2L1/PIK3R1/PIK3CA/GSK3B/BBC3/HSPA1A/HSPA6/TRAF3/STAT2/CSNK2B/BAX/ADAR/RELA/IL2RG/MYD88/IL1A/NFKBIB/TBK1/STAT5B/PIK3CD/STAT5A/OAS2/CASP9/IFNB1/BAD/TLR2/MX2/IRF3/FADD/PIK3R3/TAB2/TLR4/MAP3K7/IL6/EIF2AK2/CASP8/TLR7/IKBKB/JUN/MSN/CHUK/OAS1/MAVS/IKBKG/PIK3CB/IKBKE/NFKB1/BID/FAS/TNFAIP3/IRAK4/MAPK8	7.44187417083208
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	52/1938	105/9376	2.39595066096614	PLAU/GADD45A/CXCL2/GADD45B/NFKBIA/BCL2A1/LY96/CXCL3/CD14/TNFRSF1A/TNFSF13B/UBE2I/ICAM1/IL1B/PPP1R13L/BIRC3/CFLAR/TRADD/BCL2L1/SYK/TNF/NFKB2/TRAF3/CSNK2B/RELA/BLNK/CD40/MYD88/BTK/CCL4/XIAP/PTGS2/TAB3/RELB/RIPK1/BIRC2/BCL10/PRKCB/TAB2/TLR4/LTBR/MAP3K7/IKBKB/GADD45G/CYLD/CHUK/TICAM1/IKBKG/NFKB1/EDARADD/TNFAIP3/IRAK4	7.3423632263214
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	41/1938	77/9376	2.57606583303178	TGFBR1/GADD45A/CDKN1A/KRAS/GADD45B/NFKBIA/RUNX1/CDKN2A/SOS1/SMAD4/BCL2L1/PIK3R1/PIK3CA/SOS2/BCR/MAPK3/MDM2/BAX/CTBP2/RELA/TGFB2/STAT5B/SMAD3/RB1/PIK3CD/STAT5A/BAD/TGFBR2/PIK3R3/DDB2/IKBKB/GADD45G/CHUK/SHC1/ARAF/IKBKG/PIK3CB/MAPK1/CRK/NFKB1/NRAS	7.08820110060226
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	46/1938	93/9376	2.39297801746618	FN1/LAMB4/BIRC7/GADD45A/CDKN1A/ITGB1/GADD45B/ITGA2/NFKBIA/ITGA6/ITGA3/RXRA/PTK2/BIRC3/CDKN2B/LAMA5/BCL2L1/LAMC2/PIK3R1/LAMB3/PIK3CA/LAMB2/COL4A5/LAMA3/TRAF3/BAX/RELA/LAMC1/RXRB/XIAP/PTGS2/MAX/RB1/PIK3CD/COL4A2/CASP9/BIRC2/PIK3R3/DDB2/IKBKB/GADD45G/TRAF4/CHUK/IKBKG/PIK3CB/NFKB1	6.89090082450078
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	46/1938	95/9376	2.34259953288795	HLA-DRA/CTSL/HLA-DRB1/HLA-DPA1/HLA-DPB1/CXCL2/ACP5/ATP6V0E1/ITGB2/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/ATP6V0D1/FLT1/CCL3/ATP6V1D/CXCL3/FOS/TNFSF13B/ATP6V1E1/ICAM1/HLA-DQA2/IL18/ATP6V1G1/IL1B/CCL5/CD86/TCIRG1/TNF/ATP6AP1/ATP6V1H/ATP6V1C1/CCL20/ATP6V0B/HLA-DOA/IL1A/TGFB2/VEGFA/ITGAL/TLR2/HLA-DRB5/TLR4/IL6/JUN/CCL3L3	6.7134436134196
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	82/1938	214/9376	1.85380438451819	HLA-B/KRAS/HLA-A/NFKBIA/TAPBP/ITPR2/LIMK2/TAPBPL/CALM2/CXCR4/TNFRSF1A/FOS/PTK2/CD4/PAK2/HLA-F/GNA11/TRADD/BCL2L1/SAMHD1/PIK3R1/AP1M2/PIK3CA/RAC1/GNAQ/NFATC2/MAP2K3/BST2/HLA-E/TAP1/TNF/GNAI2/MAPK3/AP1S2/B2M/FBXW11/BAX/RELA/RAC2/AP1G1/MYD88/TBK1/CUL5/TNFRSF1B/PIK3CD/PPP3CA/PXN/CASP9/RIPK1/IFNB1/BAD/TLR2/IRF3/SKP1/FADD/PIK3R3/PRKCB/MAP2K7/TAB2/TLR4/CFL2/MAP3K7/CASP8/IKBKB/NFATC3/JUN/CHUK/GNB1/WEE1/IKBKG/PIK3CB/MAPK1/CRK/NFKB1/RBX1/BID/FAS/GNB4/IRAK4/MAPK8/PAK1/NRAS	6.44918093109632
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	45/1938	93/9376	2.34095675621692	TGFBR1/EGFR/MYL12B/TJP1/MYL12A/ACTN4/PTPRF/MET/BAIAP2/ARHGAP29/IGF1R/MYL9/SMAD4/RAP1B/TCF7L1/SMURF2/CREBBP/PTPN6/RAC1/MAPK3/WAS/ACTN1/INSR/CSNK2B/PTPRJ/PTPN1/IQGAP1/RAC2/CDH1/EP300/ACTB/SMAD3/PDCD10/WASF2/CCM2/TGFBR2/PTPRM/VCL/RAP1A/PARD3/CTNNA1/MAP3K7/SMURF1/MAPK1/YES1	6.63355767368337
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	45/1938	93/9376	2.34095675621692	HLA-DRA/HLA-DRB1/HLA-DPA1/JAK1/HLA-DPB1/GATA3/IFNGR1/NFKBIA/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/STAT1/MAML2/FOS/CD4/HLA-DQA2/NOTCH3/JAG1/STAT6/NFATC2/IL4R/NOTCH2/STAT4/MAPK3/NOTCH1/RELA/IL2RG/HLA-DOA/RBPJ/NFKBIB/STAT5B/STAT5A/PPP3CA/IFNGR2/NFKBIE/HLA-DRB5/IKBKB/NFATC3/JUN/CHUK/IKBKG/MAPK1/NFKB1/MAPK8	6.63355767368337
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	75/1938	193/9376	1.88004299074416	CXCR6/CXCL2/KRAS/NFKBIA/CXCL16/STAT1/CCL3/CXCR4/CXCL3/STAT3/SOS1/PTK2/VAV2/RAP1B/ARRB1/TIAM1/CCL5/PIK3R1/PIK3CA/RAC1/GSK3B/GNAQ/CCL18/SOS2/BCAR1/HCK/ARRB2/GNAI2/MAPK3/WAS/DOCK2/STAT2/FGR/CCL28/RELA/RAC2/CCL20/VAV3/CCL4/CXCL9/NFKBIB/VAV1/CXCL10/STAT5B/PIK3CD/PXN/XCR1/FOXO3/PLCB2/BAD/PREX1/PIK3R5/PLCB1/RAP1A/PARD3/PIK3R3/PRKCB/ADCY9/CCR1/ADCY7/IKBKB/CHUK/SHC1/GNB1/IKBKG/PIK3CB/MAPK1/CRK/NFKB1/PRKACB/GNB4/CCL7/CCL3L3/PAK1/NRAS	6.30557489117875
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	68/1938	170/9376	1.93519091847265	MYL12B/AMOTL2/TJP1/MYL12A/NEDD4L/ACTN4/ITGB1/PRKAB2/MYL6/ARPC2/SYNPO/CLDN4/RUNX1/TJP2/AMOT/F11R/CRB3/MYH9/TUBA1A/ARPC5/MYL9/ARPC3/RDX/RAPGEF2/HCLS1/TIAM1/PARD6B/MAP3K5/EZR/PRKAG2/LLGL2/CLDN19/CLDN23/MPDZ/ACTR3/AMOTL1/SYMPK/VASP/RAC1/YBX3/ARHGEF2/PPP2R2A/CGN/PPP2R2B/WAS/ACTN1/NEDD4/CLDN7/PPP2CB/CTTN/ACTB/PPP2CA/CLDN1/ARPC1B/ARPC5L/RAP1A/PARD3/MAP2K7/PRKCI/MAP3K1/TUBA4A/ARHGEF18/JUN/MSN/STK11/RAP2C/PRKACB/MAPK8	6.28092624647339
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	35/1938	66/9376	2.56559402070238	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/GATA3/IFNGR1/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/STAT1/STAT3/HLA-DQA2/IL18/IL1B/STAT6/IL4R/TNF/STAT4/RELA/IL2RG/HLA-DOA/IL1A/TGFB2/SMAD3/IL10/IFNGR2/SMAD2/TLR2/HLA-DRB5/TLR4/IL6/JUN/TLR5/NFKB1	6.51494447694523
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	60/1938	144/9376	2.01582387340901	CXCL2/PRKAB2/NFKBIA/C1QA/C1QB/ACOX1/ACADVL/LY96/C5AR1/CXCL3/CD14/TNFRSF1A/ADIPOR1/SCD5/TCF7L1/IL1B/MAP3K5/C1QC/TRADD/PRKAG2/C3AR1/GSK3B/MAP2K3/LPIN2/TNF/C2/TRAF3/RELA/LPIN1/MYD88/TAB3/TBK1/C3/NOX4/FOXO1/RIPK1/FOXO3/IFNB1/IRF3/FADD/CAMKK2/MAP2K7/MAP2K4/TAB2/TLR4/MAP3K7/IL6/CASP8/IL17RC/IKBKB/CHUK/TICAM1/PPARA/IKBKG/IKBKE/NFKB1/FAS/IRAK4/ACADM/MAPK8	6.27026940484245
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	54/1938	125/9376	2.09000619195046	CTSD/ASAH1/KRAS/FCER1G/TNFRSF1A/BDKRB2/PDPK1/MAP3K5/TRADD/PPP2R3A/PLD1/PIK3R1/PIK3CA/RAC1/GNAQ/DEGS1/SMPD1/PPP2R2A/TNF/ORMDL1/SGMS2/GNAI2/MAPK3/PPP2R2B/PPP2R5E/GNA13/BAX/RELA/SGMS1/RAC2/PPP2CB/PPP2CA/PIK3CD/ORMDL3/PLCB2/CERS6/SPTLC3/NSMAF/SPTLC2/ADORA3/PLCB1/PIK3R3/PRKCB/SGPL1/PLD2/SPHK1/PIK3CB/MAPK1/S1PR4/NFKB1/PPP2R3C/BID/MAPK8/NRAS	6.26215868532901
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	37/1938	73/9376	2.45212547888658	EGFR/GADD45A/CDKN1A/KRAS/GADD45B/MET/CDKN2A/STAT3/SOS1/RXRA/PDPK1/EML4/PIK3R1/PIK3CA/SOS2/MAPK3/BAX/RXRB/STK4/KIF5B/STAT5B/RB1/PIK3CD/STAT5A/CASP9/FOXO3/BAD/PIK3R3/PRKCB/DDB2/GADD45G/ARAF/PIK3CB/RASSF5/MAPK1/RASSF1/NRAS	6.35753123709788
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	52/1938	120/9376	2.09645682834537	ARHGDIB/KRAS/NFKBIA/CALM2/SOS1/RAP1B/PDPK1/MAP3K5/FRS2/PIK3R1/PIK3CA/RAC1/GSK3B/RIPK2/SOS2/GAB1/ATF4/RAPGEF1/MAPK3/BAX/RELA/CAMK2D/NFKBIB/ARHGDIA/PIK3CD/SH2B3/NFKBIE/FOXO3/BAD/PRDM4/RAP1A/MATK/PIK3R3/MAPKAPK2/MAP2K7/BDNF/PSEN1/MAP3K1/NTF4/KIDINS220/IKBKB/JUN/SHC1/PSEN2/PIK3CB/MAPK1/CRK/NFKB1/RPS6KA1/IRAK4/MAPK8/NRAS	6.17028073710329
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	77/1938	205/9376	1.81719147222432	GSN/IL6ST/HLA-B/PMAIP1/JAK1/CDKN1A/ACTN4/KRAS/HLA-A/NFKBIA/SP100/ATP6V0D1/CREB5/SCIN/CDKN2A/CREB3L2/STAT3/HLA-F/CDKN2B/TRADD/YWHAZ/CREBBP/USP7/PIK3R1/PIK3CA/RAC1/SYK/UBR4/HLA-E/HDAC7/ATF4/RASA2/MAPK3/MDM2/NFKB2/ACTN1/TRAF3/BAX/RELA/GTF2A2/CREB3/RBL2/EP300/RBPJ/HDAC10/STAT5B/YWHAH/RB1/PIK3CD/C3/STAT5A/YWHAG/PXN/GTF2B/BAD/IRF3/UBE3A/PIK3R3/MAPKAPK2/LTBR/VAC14/EIF2AK2/CASP8/JUN/ATF6B/SNW1/KAT2B/IKBKG/GTF2H1/PIK3CB/MAPK1/NFKB1/PRKACB/MAD1L1/TBP/EGR2/NRAS	6.03846908601522
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	45/1938	98/9376	2.22152018702218	GSN/MARCKS/ARPC2/FCGR3A/LIMK2/SCIN/INPPL1/ARPC5/ARPC3/ASAP2/PTPRC/VAV2/PIP5K1B/FCGR1A/PLD1/ACTR3/PIK3R1/PIK3CA/FCGR2A/VASP/RAC1/SYK/ASAP1/HCK/MAPK3/WAS/RAC2/VAV3/VAV1/PIK3CD/WASF2/ARPC1B/INPP5D/ARPC5L/ARF6/PIK3R3/PRKCB/CFL2/PLD2/PIP5K1C/SPHK1/PIK3CB/MAPK1/CRK/PAK1	6.20470216978035
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	63/1938	157/9376	1.94135394687543	SERPINE1/TGFBR1/HLA-B/CAPN2/GADD45A/CDKN1A/KRAS/GADD45B/SQSTM1/HLA-A/ZFP36L1/RRAS/ITPR2/MRAS/CALM2/CDKN2A/HLA-F/IGFBP3/CDKN2B/ZFP36L2/RAD50/PIK3R1/PIK3CA/NFATC2/RRAS2/MAP2K3/HLA-E/HIPK3/CAPN1/MAPK3/MDM2/RHEB/FBXW11/E2F4/RELA/RBL2/MCU/HIPK1/IL1A/TGFB2/SMAD3/RB1/PIK3CD/PPP3CA/EIF4EBP1/SMAD2/FOXO1/FOXO3/TSC2/TGFBR2/TSC1/PIK3R3/MAPKAPK2/IL6/NFATC3/HIPK2/GADD45G/NBN/PIK3CB/RASSF5/MAPK1/NFKB1/NRAS	6.07149028030839
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	119/1938	362/9376	1.59038480178346	SPP1/FN1/ITGB6/IGF2/ITGB4/LAMB4/EGFR/PDGFA/EFNA1/CSH1/JAK1/CDKN1A/KRAS/ITGB1/CSH2/ITGA2/ITGA6/CSF1R/MET/CREB5/FLT1/ERBB3/ITGA3/MCL1/CSF3R/OSMR/IGF1R/CREB3L2/SOS1/RXRA/PTK2/PDGFB/FGFR2/PDPK1/IFNAR1/LAMA5/PPP2R3A/YWHAZ/BCL2L1/LAMC2/PIK3R1/EREG/LAMB3/PIK3CA/LAMB2/RAC1/GSK3B/FGF1/SYK/OSM/IL4R/SOS2/PPP2R2A/COL4A5/ATF4/MAPK3/PPP2R2B/MDM2/RHEB/PPP2R5E/PIK3AP1/IL6R/INSR/LAMA3/PKN2/SGK1/RELA/EFNA5/IL2RG/CREB3/LAMC1/RBL2/EPHA2/PPP2CB/EIF4E2/PHLPP2/YWHAH/PPP2CA/PIK3CD/THBS1/COL4A2/YWHAG/VEGFA/EIF4EBP1/CASP9/FOXO3/IFNB1/BAD/TLR2/TSC2/TSC1/PIK3R5/THBS3/HSP90AA1/IL7R/PIK3R3/BDNF/NTF4/TLR4/IL6/PKN1/LPAR6/IKBKB/AREG/ATF6B/CHUK/GNB1/IKBKG/PIK3CB/STK11/MAPK1/BCL2L11/NFKB1/PPP2R3C/CRTC2/CSHL1/ITGB3/GNB4/NRAS	5.84743112240876
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	41/1938	87/9376	2.27996631199364	TGFBR1/EGFR/PMAIP1/GADD45A/CDKN1A/KRAS/GADD45B/RALGDS/FOS/SOS1/SMAD4/TCF7L1/PIK3R1/EREG/PIK3CA/RAC1/GSK3B/BBC3/SOS2/MAPK3/RALA/BAX/RAC2/TGFB2/SMAD3/PIK3CD/SMAD2/CASP9/BAD/TGFBR2/PIK3R3/DDB2/GADD45G/AREG/JUN/ARAF/PIK3CB/MAPK1/BCL2L11/MAPK8/NRAS	6.12220858219109
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	46/1938	103/9376	2.16065005460539	FN1/HSPB1/LAMB4/ACTN4/CXCL2/ITGB2/CXCL3/CD14/PTK2/RAB5A/IL1B/GNA11/LAMA5/LAMC2/PIK3R1/LAMB3/PIK3CA/LAMB2/GNAQ/RAB5C/COL4A5/TNF/ITGAM/ACTN1/LAMA3/PRDX1/RELA/RAB5B/LAMC1/RAB7A/GNA15/TGFB2/PIK3CD/COL4A2/IL10/PLCB2/TLR2/VCL/PLCB1/PIK3R3/PRKCB/TLR4/IL6/PIK3CB/NFKB1/PRKACB	6.045666915798
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	45/1938	101/9376	2.15553443889281	FN1/SERPINE1/TGFBR1/KRAS/STAT1/PIM1/STAT3/SMAD4/ICAM1/CYBB/IL1B/PLCD3/PIK3R1/PIK3CA/RAC1/COL4A5/TNF/MAPK3/DIAPH1/BAX/RELA/EDN1/IL1A/TGFB2/STAT5B/SMAD3/PIK3CD/STAT5A/COL4A2/NOX4/VEGFA/SMAD2/FOXO1/PLCB2/TGFBR2/PLCB1/PIK3R3/PRKCB/IL6/JUN/PIK3CB/MAPK1/NFKB1/MAPK8/NRAS	5.95965416682995
NA	NA	hsa04518	Integrin signaling	61/1938	154/9376	1.91634165627974	SPP1/FN1/ITGB6/FBN1/ITGB4/LAMB4/EGFR/PDGFA/ACTN4/ITGB1/ITGA2/ITGA6/ITGB2/MET/FLT1/ITGA3/IGF1R/PTK2/PDGFB/ICAM1/FERMT3/LAMA5/FLNA/ILK/LAMC2/ITGAX/PIK3R1/LAMB3/PIK3CA/LAMB2/RAC1/GSK3B/FLNB/FERMT1/COL4A5/PARVG/ITGAM/NPNT/ACTN1/LAMA3/FERMT2/LAMC1/RAC2/CDH1/ACTB/PIK3CD/C3/THBS1/COL4A2/PXN/VEGFA/ITGAL/VCL/THBS3/PIK3R3/TLN1/PARVB/LIMS1/PIK3CB/NCK2/ITGB3	5.85247636880696
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	34/1938	68/9376	2.41898864809082	KRAS/CSF1R/RUNX1/BCL2A1/PIM1/CD14/JUP/SPI1/CEBPA/STAT3/SOS1/TCF7L1/FCGR1A/PIK3R1/PIK3CA/SOS2/MAPK3/ITGAM/RELA/STAT5B/PIK3CD/STAT5A/EIF4EBP1/BAD/PER2/PIK3R3/IKBKB/CHUK/ARAF/IKBKG/PIK3CB/MAPK1/NFKB1/NRAS	5.99431591666771
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	51/1938	122/9376	2.02243313201035	CSH1/KRAS/JUNB/CSH2/ITPR2/CREB5/STAT1/IRS2/CREB3L2/FOS/STAT3/SOS1/PTK2/IGFBP3/GNA11/SOCS3/CREBBP/PIK3R1/PIK3CA/GSK3B/GNAQ/SOS2/BCAR1/MAP2K3/ATF4/GNAI2/MAPK3/CREB3/SOCS2/EP300/STAT5B/PIK3CD/STAT5A/PLCB2/PLCB1/SOCS1/PIK3R3/PRKCB/MAP2K4/ADCY9/MAP3K1/ADCY7/ATF6B/SHC1/PIK3CB/MAPK1/CRK/PRKACB/CSHL1/MAPK8/NRAS	5.80209078208369
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	49/1938	116/9376	2.04362834062845	CD99/MYL12B/MYL12A/ACTN4/ITGB1/ITGB2/CLDN4/F11R/CXCR4/NCF2/PTK2/MYL9/ICAM1/VAV2/CYBB/RAP1B/SIPA1/EZR/MMP9/CLDN19/CLDN23/PIK3R1/PIK3CA/ESAM/VASP/RAC1/NCF4/BCAR1/GNAI2/ITGAM/ACTN1/CLDN7/RAC2/VAV3/ACTB/VAV1/PIK3CD/PXN/ITGAL/CLDN1/VCL/RAP1A/PIK3R3/PRKCB/CD99L2/CTNNA1/MSN/PIK3CB/RASSF5	5.77302984977079
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	37/1938	78/9376	2.29493794818872	SERPING1/IRF1/ITGB1/ITGB2/C1QA/C1QB/LY96/CALM2/CD14/FOS/IL1B/IRF8/C1QC/CASP1/TNF/GNAI2/MAPK3/ITGAM/C2/RELA/MYD88/CASP7/IL1A/C3/IL10/IRF3/TLR4/CFL2/IL6/C4BPB/JUN/TICAM1/MAPK1/NFKB1/NLRP3/IRAK4/MAPK8	5.86186653479918
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	42/1938	94/9376	2.16164943020881	CXCL2/JUND/NFKBIA/CXCL3/FOS/IL1B/TRADD/MMP9/S100A8/GSK3B/TNF/S100A9/MAPK3/IL17RE/TRAF3/RELA/CCL20/PTGS2/TAB3/FOSB/TBK1/CXCL10/CEBPB/FADD/HSP90AA1/TAB2/S100A7/MAP3K7/IL6/CASP8/IL17RC/IKBKB/JUN/TRAF4/CHUK/IKBKG/MAPK1/IKBKE/NFKB1/CCL7/TNFAIP3/MAPK8	5.77766911109955
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	34/1938	70/9376	2.34987468671679	CDKN1A/EPAS1/KRAS/MET/SOS1/PDGFB/PAK2/RAP1B/CREBBP/PIK3R1/PIK3CA/RAC1/SOS2/GAB1/RAPGEF1/MAPK3/HIF1A/EP300/TGFB2/PIK3CD/VEGFA/BAD/RAP1A/PIK3R3/JUN/ARAF/PIK3CB/FLCN/MAPK1/CRK/RBX1/CUL2/PAK1/NRAS	5.78622592548224
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	50/1938	122/9376	1.98277758040231	KRAS/NFKBIA/FOS/SOS1/CD4/PAK2/PTPRC/VAV2/PDPK1/PPP2R3A/PIK3R1/PIK3CA/PTPN6/GSK3B/LCP2/NFATC2/SOS2/PPP2R2A/TNF/MAPK3/PPP2R2B/PPP2R5E/RELA/VAV3/PPP2CB/NFKBIB/VAV1/PPP2CA/PIK3CD/IL10/PPP3CA/NFKBIE/BCL10/PIK3R3/MAP2K7/NCK1/MAP3K7/IKBKB/NFATC3/JUN/CHUK/IKBKG/PIK3CB/NCK2/MAPK1/NFKB1/PPP2R3C/MAPK8/PAK1/NRAS	5.57705395254445
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	37/1938	80/9376	2.237564499484	EGFR/PDGFA/JAK1/KRAS/MET/ERBB3/IGF1R/AXL/STAT3/SOS1/PDGFB/FGFR2/BCL2L1/PIK3R1/PIK3CA/GSK3B/SOS2/GAB1/MAPK3/IL6R/BAX/EIF4E2/PIK3CD/VEGFA/EIF4EBP1/FOXO3/BAD/PIK3R3/PRKCB/GAS6/IL6/SHC1/ARAF/PIK3CB/MAPK1/BCL2L11/NRAS	5.67412914570541
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	29/1938	56/9376	2.50538109980834	CXCL2/NFKBIA/ITGB2/HSPA1B/CXCL3/CD14/IL18/IL1B/CASP1/RAB1A/HSPA1A/HSPA6/TNF/ITGAM/NFKB2/CLK1/RELA/MYD88/CASP7/NAIP/C3/CASP9/TLR2/TLR4/ARF1/IL6/CASP8/TLR5/NFKB1	5.76722578192808
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	65/1938	174/9376	1.80729036926325	MAN1A1/CAPN2/NFE2L2/UBE2J1/BCAP31/DNAJB1/HSPA1B/WFS1/PPP1R15A/MBTPS1/SEC31A/MAP3K5/ATF6/HERPUD1/DNAJB2/TRAM1/AMFR/BCAP29/UBE2D3/HSPA1A/UBE2G1/SIL1/ATF4/HSPA6/SEL1L/MOGS/UBQLN1/UBE2D1/EDEM1/CAPN1/DNAJC1/BAX/STUB1/SEC23A/EDEM2/UGGT2/DNAJA1/HSPH1/SEC24D/RNF5/SEC62/ERLEC1/NPLOC4/UBE2D4/SKP1/EIF2AK3/MAN1B1/HSP90AA1/DNAJB12/DNAJC5/MAP2K7/RNF185/UBXN1/OS9/UBXN6/ATF6B/RAD23B/UBQLN2/UBXN2A/XBP1/UBXN4/SYVN1/RBX1/RAD23A/MAPK8	5.48652950091851
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	31/1938	62/9376	2.41898864809082	MAML2/CIR1/DTX3L/ATXN1/CREBBP/NOTCH3/JAG1/PSENEN/NCSTN/NOTCH2/TLE6/TLE1/TLE2/CTBP2/NOTCH1/HES1/EP300/LFNG/ADAM17/RBPJ/TLE4/PSEN1/MFNG/APH1A/ATXN1L/SPEN/PSEN2/SNW1/KAT2B/DVL3/APH1B	5.72191084469925
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	45/1938	106/9376	2.05385828611484	EGFR/PDGFA/PLAU/FOLR1/CDKN1A/KRAS/SPINT1/NFKBIA/CREB5/IGF1R/CREB3L2/SOS1/PDGFB/FGFR2/PDPK1/TCF7L1/MMP9/CREBBP/PIK3R1/PIK3CA/GSK3B/SOS2/ATF4/MAPK3/MDM2/SLC46A1/RELA/CREB3/EP300/RB1/PIK3CD/CASP9/FOXO1/BAD/HSP90AA1/PIK3R3/IKBKB/CHUK/ARAF/IKBKG/PIK3CB/MAPK1/NFKB1/FOLR2/NRAS	5.56967325064239
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	40/1938	90/9376	2.15021213163628	EGFR/JAK1/KRAS/IFNGR1/NFKBIA/STAT1/FOS/STAT3/CD4/EML4/PIK3R1/PIK3CA/PTPN6/BATF3/NFATC2/MAP2K3/MAPK3/HIF1A/CSNK2B/RELA/MYD88/NFKBIB/BATF/PIK3CD/PPP3CA/IFNGR2/NFKBIE/TLR2/PIK3R3/TLR4/IKBKB/NFATC3/JUN/CHUK/TICAM1/IKBKG/PIK3CB/MAPK1/NFKB1/NRAS	5.59653593292864
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	60/1938	158/9376	1.83720656817024	CLIP1/WNT6/KRAS/SLC38A9/FZD5/WNT10A/ATP6V1D/TNFRSF1A/IGF1R/SOS1/WNT7A/ATP6V1E1/WNT11/PDPK1/ULK1/ATP6V1G1/PIK3R1/PIK3CA/GSK3B/SOS2/LPIN2/CAB39/TNF/MAPK3/RHEB/ATP6V1H/INSR/RRAGD/SGK1/ATP6V1C1/RRAGC/FNIP1/WDR59/LPIN1/EIF4E2/SLC7A5/PIK3CD/EIF4EBP1/FZD1/LAMTOR3/TSC2/TSC1/FZD6/PIK3R3/PRKCB/IKBKB/ULK2/CHUK/LAMTOR5/RRAGA/WNT5A/SLC3A2/PIK3CB/STK11/FLCN/MAPK1/DVL3/RPS6KA1/WNT9A/NRAS	5.41722976454528
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	38/1938	86/9376	2.13771089831281	EGFR/CDKN1A/KRAS/ERBB3/SOS1/PTK2/PAK2/PIK3R1/EREG/PIK3CA/GSK3B/SOS2/GAB1/MAPK3/HBEGF/ABL2/CAMK2D/STAT5B/PIK3CD/STAT5A/EIF4EBP1/BAD/PIK3R3/PRKCB/MAP2K7/MAP2K4/NCK1/AREG/JUN/SHC1/ARAF/PIK3CB/NCK2/MAPK1/CRK/MAPK8/PAK1/NRAS	5.41013029348955
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	42/1938	99/9376	2.0524752165619	EGFR/PDGFA/KRAS/RALGDS/SLC44A2/FOS/SOS1/PDGFB/PDPK1/PIP5K1B/PLD1/PIK3R1/PIK3CA/RAC1/DGKH/SOS2/SLC22A5/MAPK3/RHEB/WAS/HIF1A/DGKA/GPCPD1/RAC2/PIK3CD/WASF2/EIF4EBP1/CHKB/TSC2/TSC1/PIK3R3/PRKCB/JUN/PLD2/PIP5K1C/SLC22A4/SLC44A5/PIK3CB/MAPK1/SP1/MAPK8/NRAS	5.3735356502349
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	62/1938	168/9376	1.78544400216227	IL6ST/EGFR/PDGFA/CSH1/JAK1/CDKN1A/CSH2/IFNGR1/CSF2RA/STAT1/PIM1/MCL1/CSF3R/OSMR/STAT3/SOS1/PDGFB/CSF2RB/IFNAR1/SOCS3/BCL2L1/CREBBP/PIK3R1/PIK3CA/PTPN6/STAT6/IL13RA1/OSM/IL4R/SOS2/PIAS1/STAT4/IL6R/STAT2/CISH/IFNL2/IL2RG/SOCS6/SOCS2/IFNL1/EP300/IL10RB/STAT5B/PIK3CD/STAT5A/IL10/IFNGR2/IFNB1/IL27/IFNL3/IL7R/SOCS1/PIK3R3/IL6/IL27RA/CTF1/PIK3CB/IL31RA/STAM/CSHL1/IL11RA/IL15RA	5.24350456900471
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	36/1938	82/9376	2.12399003246998	HLA-DRA/CTSB/LGMN/CTSL/CD74/HLA-DRB1/HLA-B/HLA-DPA1/CTSS/HLA-DPB1/HLA-A/HLA-DQA1/TAPBP/HLA-DMA/HLA-DQB1/HSPA1B/HLA-DMB/TAPBPL/CD4/HLA-F/HLA-DQA2/PSME1/HSPA1A/HLA-E/TAP1/HSPA6/TNF/B2M/IFI30/HSPA2/HLA-DOA/PSME2/HSP90AA1/HLA-DRB5/CIITA/NFYC	5.21798095444013
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	58/1938	157/9376	1.78727823680595	ABCA1/CD47/C1QA/TMEM30A/C1QB/GULP1/AXL/DUSP2/RXRA/PTK2/RAB5A/ADAM9/CD36/HAVCR2/LRP1/LIPA/ALOX5/ANO6/C1QC/ADAM10/CASP1/PTPN6/RAC1/NFATC2/BCAR1/P2RY6/TMEM30B/PTGER4/RAB5C/PLA2G15/MAPK3/HIF1A/SGK1/RAB5B/RAB7A/ADAM17/PTGS2/CAMK2D/CASP7/RAB14/THBS1/IL10/ATP11A/VPS41/CEBPB/DUSP8/MAPKAPK2/VPS11/GAS6/NFATC3/PANX1/SPHK1/MAPK1/CRK/VPS39/GPR132/ITGB3/SIGLEC10	5.07774167042208
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	48/1938	122/9376	1.90346647718622	RCAN1/KRAS/STAT1/NCOA3/MED13L/RXRA/PDPK1/PLCD3/CREBBP/NOTCH3/NCOA1/PFKP/PIK3R1/MED13/PIK3CA/GSK3B/NOTCH2/MAPK3/SLC16A2/MDM2/RHEB/THRB/HIF1A/NCOR1/MED12/NOTCH1/MED16/RXRB/EP300/ACTB/ATP1B1/PIK3CD/CASP9/FOXO1/MED4/PLCB2/BAD/TSC2/PLCB1/PIK3R3/PRKCB/KAT2B/PIK3CB/MAPK1/PRKACB/SLC9A1/ITGB3/NRAS	5.12698029346596
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	61/1938	168/9376	1.75664651825643	FTL/FTH1/CAPN2/JAK1/SQSTM1/GLUL/IFNGR1/STAT1/CHMP5/TNFRSF1A/TLR3/STAT3/CYBB/TNFSF10/IFNAR1/IL1B/BIRC3/CFLAR/TRADD/CASP1/CHMP4C/CHMP1A/STAT6/VPS4B/CHMP1B/SMPD1/TNF/STAT4/CAPN1/STAT2/BAX/PYGB/CHMP2A/XIAP/CAMK2D/IL1A/STAT5B/SHARPIN/STAT5A/IFNGR2/RIPK1/IFNB1/BIRC2/FADD/HSP90AA1/DNM1L/TLR4/RBCK1/EIF2AK2/CHMP3/CASP8/CYLD/CHMP2B/TICAM1/TNFRSF10A/NLRP3/BID/FAS/VPS4A/TNFAIP3/MAPK8	5.05125695107086
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	19/1938	32/9376	2.87254901960784	PMAIP1/BIRC7/TNFRSF1A/BIRC3/BCL2L1/BBC3/BAX/BECN1/XIAP/CASP7/CASP9/BIRC2/BIRC6/FADD/BOK/CASP8/BCL2L11/BID/MAPK8	5.41596946695494
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	32/1938	70/9376	2.21164676396875	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/ITGB2/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/ICAM1/HLA-F/HLA-DQA2/SGCE/CD86/RAC1/HLA-E/CD55/CD40/RAC2/ABL2/DAG1/EIF4G2/HLA-DOA/ACTB/ITGAL/CASP9/HLA-DRB5/CASP8/SNTB2/BID	5.19371315514824
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	38/1938	90/9376	2.04270152505447	KRAS/PRKAB2/CREB5/IRS2/IGF1R/ADIPOR1/CREB3L2/SESN1/ULK1/PRKAG2/PIK3R1/PIK3CA/ATF4/RHEB/INSR/RB1CC1/BAX/RELA/CREB3/EIF4E2/PIK3CD/EIF4EBP1/FOXO1/FOXO3/TSC2/CAMKK2/TSC1/PIK3R3/ADCY9/SOD2/ADCY7/ATF6B/PIK3CB/STK11/NFKB1/PRKACB/EHMT1/NRAS	5.07342636352241
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	32/1938	71/9376	2.18049680954665	EGFR/TJP1/CXCL2/ATP6V0E1/NFKBIA/MET/ATP6V0D1/F11R/ATP6V1D/CXCL3/ATP6V1E1/ATP6V1G1/CCL5/ADAM10/RAC1/TCIRG1/ATP6AP1/ATP6V1H/HBEGF/ATP6V1C1/RELA/ATP6V0B/GIT1/ADAM17/MAP2K4/IKBKB/JUN/CHUK/IKBKG/NFKB1/MAPK8/PAK1	5.09647902116346
NA	NA	hsa04517	IgSF CAM signaling	95/1938	299/9376	1.53714997704768	MYL12B/IL1RAP/TJP1/MYL12A/ACTN4/ITGB1/MYL6/ARPC2/RASA1/PTPRF/ITGB2/TJP2/F11R/BAIAP2/MYH9/CD84/TUBA1A/ARPC5/PTK2/MYL9/CD48/ARPC3/RDX/ICAM1/TUBB2A/PAK2/VAV2/RAP1B/RAPGEF2/PDPK1/PARD6B/EZR/CD86/MPDZ/ACTR3/ITGAX/PIK3R1/PIK3CA/ESAM/PTPN6/RAC1/GSK3B/LCP2/BCAR1/SRGAP2/NRP1/MAPK3/ITGAM/DOK2/ACTN1/CADM1/L1CAM/IQGAP1/CDH1/VAV3/GIT1/NLGN4X/TRIO/SLAMF7/MBP/SPTAN1/ACTB/VAV1/CABLES1/GLDN/PIK3CD/PXN/APP/ITGAL/FOXO1/GRIP1/ARPC1B/INPP5D/SPTBN1/ARPC5L/VCL/ARF6/RAP1A/PARD3/PIK3R3/PRKCB/PRKCI/NCK1/TUBA4A/DOK1/MSN/EPB41L1/MAG/PIK3CB/NCK2/MAPK1/ITGB3/MAPK8/PAK1/PVR	4.81830653111346
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	53/1938	142/9376	1.80572392040582	BIRC7/NEDD4L/UBC/UBE2J1/UBE2H/UBE2L6/UBE2A/UBE2I/SMURF2/BIRC3/SOCS3/UBE2B/UBE2D3/HERC1/UBE2Q1/PIAS1/UBE2G1/HERC4/UBA7/UBE2D1/UBE2E3/ANAPC13/MDM2/FBXW11/STUB1/NEDD4/MID1/XIAP/CUL5/CUL3/UBE2E1/UBE2D4/SKP1/BIRC2/TRIP12/BIRC6/UBE3A/FZR1/SOCS1/MAP3K1/SMURF1/UBE2F/DDB2/UBE2E2/UBA3/WWP2/UBE2W/SYVN1/RBX1/UBB/CUL2/UBE2R2/PPIL2	4.93821428955443
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	53/1938	142/9376	1.80572392040582	CTSL/PDGFA/DUSP1/SQSTM1/BMPR2/NFE2L2/HMOX1/TXN/SDC4/CALM2/TNFRSF1A/NCF2/FOS/GSTT1/PTK2/PDGFB/ICAM1/IL1B/MAP3K5/MMP9/PIK3R1/PIK3CA/RAC1/ARHGEF2/TNF/RELA/RAC2/SDC2/EDN1/IL1A/ACTB/PIK3CD/GSTM3/KLF2/VEGFA/MEF2A/HSP90AA1/GPC1/PIK3R3/MAP2K7/MAP2K4/MAP3K7/CAV2/IKBKB/JUN/CHUK/SDC1/SUMO1/IKBKG/PIK3CB/NFKB1/ITGB3/MAPK8	4.93821428955443
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	28/1938	59/9376	2.29598922530654	EGFR/GADD45A/CDKN1A/KRAS/GADD45B/SOS1/PDPK1/TCF7L1/ILK/PIK3R1/PIK3CA/GSK3B/SOS2/MAPK3/BAX/CDH1/PIK3CD/CASP9/FOXO3/BAD/PIK3R3/CTNNA1/DDB2/GADD45G/ARAF/PIK3CB/MAPK1/NRAS	5.09710742224564
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	34/1938	78/9376	2.10886189833558	FN1/CLTB/ITGB1/ARPC2/MET/ARPC5/PTK2/ELMO3/ARPC3/HCLS1/ILK/ACTR3/PIK3R1/PIK3CA/RAC1/BCAR1/GAB1/CLTC/CDH1/CTTN/ACTB/PIK3CD/PXN/WASF2/RHOG/ARPC1B/ARPC5L/VCL/PIK3R3/CTNNA1/CAV2/SHC1/PIK3CB/CRK	5.01954588840263
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	78/1938	238/9376	1.58555558446289	IGF2/EGFR/PDGFA/EFNA1/KRAS/RASA1/RASAL2/CSF1R/RRAS/MET/FLT1/RALGDS/MRAS/CALM2/SHOC2/IGF1R/SOS1/RAB5A/PDGFB/FGFR2/PAK2/ETS2/RAP1B/TIAM1/PLD1/BCL2L1/PIK3R1/RASGRF2/PIK3CA/FOXO4/RAC1/FGF1/SOS2/RRAS2/RALGAPA2/GAB1/RAB5C/RASA2/MAPK3/RALA/INSR/EXOC2/RGL2/RELA/EFNA5/KSR1/RAB5B/RAC2/STK4/ABL2/EPHA2/TBK1/PIK3CD/RASGRP3/VEGFA/BAD/ARF6/RAP1A/PIK3R3/PRKCB/BDNF/NTF4/IKBKB/PLD2/CHUK/SHC1/GNB1/IKBKG/PIK3CB/RASSF5/MAPK1/NFKB1/PRKACB/RASSF1/GNB4/MAPK8/PAK1/NRAS	4.67052247650806
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	56/1938	157/9376	1.72564795277816	SERPINE1/TGFBR1/WNT6/BMPR2/ITGB2/FZD5/AMOT/WNT10A/WNT7A/SMAD4/WNT11/TCF7L1/BIRC3/PARD6B/YWHAZ/LLGL2/SMAD7/LATS2/GSK3B/FGF1/TEAD1/BBC3/STK3/PPP2R2A/AJUBA/PPP2R2B/FBXW11/MOB1A/CDH1/PPP2CB/TGFB2/ACTB/YWHAH/PPP2CA/SMAD3/RASSF6/YWHAG/SMAD2/FZD1/TGFBR2/BIRC2/CSNK1D/WWC1/FZD6/PARD3/PRKCI/CSNK1E/CTNNA1/SAV1/AREG/WWTR1/WNT5A/DVL3/RASSF1/WTIP/WNT9A	4.68024222646755
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	70/1938	212/9376	1.59744533364488	EGFR/PDGFA/EFNA1/KRAS/ITGB1/ITGB2/CSF1R/RRAS/MET/FLT1/RALGDS/MRAS/CALM2/IGF1R/PDGFB/FGFR2/VAV2/RAP1B/RAPGEF2/TIAM1/SIPA1/PARD6B/PIK3R1/PIK3CA/VASP/RAC1/FGF1/LCP2/GNAQ/BCAR1/MAP2K3/GNAI2/RAPGEF1/MAPK3/ITGAM/RALA/INSR/FPR1/EFNA5/RAC2/CDH1/VAV3/EPHA2/ACTB/VAV1/DOCK4/PIK3CD/THBS1/RASGRP3/VEGFA/ITGAL/PLCB2/PLCB1/RAP1A/PARD3/PIK3R3/PRKCB/ADCY9/PRKCI/PRKD2/TLN1/APBB1IP/ADCY7/PFN1/PIK3CB/RASSF5/MAPK1/CRK/ITGB3/NRAS	4.49115455896958
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	50/1938	138/9376	1.75289032470349	KRAS/PRKAB2/PTPRF/TRIP10/RHOQ/CALM2/INPPL1/IRS2/FLOT1/SOS1/PDPK1/SOCS3/PRKAG2/PIK3R1/PIK3CA/GSK3B/PPP1R3D/SOS2/RAPGEF1/MAPK3/RHEB/INSR/FBP1/PYGB/PTPN1/SOCS2/PHKB/EIF4E2/PIK3CD/PRKAR1A/EIF4EBP1/EXOC7/FOXO1/FLOT2/BAD/TSC2/TSC1/HK3/SOCS1/PIK3R3/PRKCI/IKBKB/SHC1/ARAF/PIK3CB/MAPK1/CRK/PRKACB/MAPK8/NRAS	4.54796085408897
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	39/1938	100/9376	1.88681114551084	HLA-DRA/CD59/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGA2/ITGA6/HLA-DQA1/CSF1R/HLA-DMA/HLA-DQB1/HLA-DMB/CD44/CD9/CSF2RA/ITGA3/CSF3R/CD37/CD14/MME/CD4/CD36/HLA-DQA2/IL1B/FCGR1A/IL4R/CD55/TNF/ITGAM/IL6R/HLA-DOA/IL1A/CD33/CD22/HLA-DRB5/IL7R/IL6/ITGB3/IL11RA	4.55077339355775
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	34/1938	83/9376	1.98182202494187	NFKBIA/IFI16/IL18/IL1B/CCL5/SAMHD1/CASP1/PCBP1/ADAR/RELA/CCL4/CASP7/TREX1/GSDMD/NFKBIB/TBK1/CXCL10/POLR2K/RIPK1/IFNB1/POLR3D/IRF3/FADD/IL6/CASP8/IKBKB/CHUK/MAVS/POLR3GL/IKBKG/IKBKE/NFKB1/NLRP3/ZDHHC1	4.58593912447736
Human Diseases	Immune disease	hsa05330	Allograft rejection	20/1938	39/9376	2.48101399804186	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-F/HLA-DQA2/CD86/HLA-E/TNF/CD40/HLA-DOA/IL10/HLA-DRB5/FAS	4.73066532938767
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	55/1938	160/9376	1.66305469556244	HLA-DRA/CD99/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/ITGB1/HLA-A/ITGA6/PTPRF/ITGB2/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/CLDN4/SDC4/F11R/ICAM1/VTCN1/CD4/HLA-F/PTPRC/HLA-DQA2/CLDN19/CD86/ALCAM/CLDN23/ESAM/HLA-E/CD276/ITGAM/CADM1/CD58/L1CAM/CD40/CLDN7/SDC2/PDCD1LG2/CDH1/NLGN4X/HLA-DOA/SIGLEC1/GLG1/ITGAL/SELPLG/CLDN1/PTPRM/CD22/HLA-DRB5/CD99L2/SPN/SDC1/MAG/PVR	4.31789970843486
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	38/1938	99/9376	1.85700138641315	EGFR/CDKN1A/KRAS/NCOA3/IGF1R/CDKN2A/FOS/SOS1/PTK2/MMP9/NOTCH3/JAG1/PIK3R1/PIK3CA/SOS2/NOTCH2/MAPK3/MDM2/NCOR1/HBEGF/BAX/NOTCH1/RB1/PIK3CD/BAD/PIK3R3/ADCY9/ADCY7/JUN/SHC1/ARAF/PIK3CB/MAPK1/PRKACB/SP1/BIK/MAPK8/NRAS	4.37552108565109
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	74/1938	233/9376	1.53652497818644	FN1/ITGB6/FBN1/FMNL2/ITGB4/PDLIM1/ITGB1/ZYX/LMNA/PLEC/ITGA2/ITGA6/PDLIM5/VIM/FBLN1/PKP2/TNNT3/DAAM1/SDC4/ITGA3/CSRP1/MYH9/JUP/TMEM43/MYL9/FBLN2/PDLIM2/SUN1/FHL2/TPM1/SGCE/PDLIM3/ANKRD1/AGRN/PDLIM7/ACTG2/DIAPH2/NEBL/COL4A5/INF2/FMNL1/DIAPH1/PDLIM4/FHL3/SYNE3/CAPZA2/SDC2/COL5A1/ACTA1/DAG1/SPTAN1/ACTB/ATP1B1/LMOD1/THBS1/COL4A2/TNNT2/AMPD3/DSC2/SPTBN1/VCL/THBS3/MYOZ1/CAPZA1/TMOD3/TLN1/SYNE1/SNTB2/CAPZB/SUN2/DSG2/SDC1/TPM3/ITGB3	4.23309469425247
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	29/1938	69/9376	2.03335277665605	KRAS/FCER1G/ALOX5AP/SOS1/VAV2/PDPK1/ALOX5/PIK3R1/PIK3CA/RAC1/SYK/LCP2/SOS2/MAP2K3/TNF/MAPK3/RAC2/BTK/VAV3/VAV1/PIK3CD/INPP5D/PIK3R3/MAP2K7/MAP2K4/PIK3CB/MAPK1/MAPK8/NRAS	4.39746849529304
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	61/1938	184/9376	1.60389464710369	EFNA1/MYL12B/MYL12A/KRAS/ITGB1/BMPR2/RASA1/RRAS/DPYSL2/MET/RHOD/LIMK2/SEMA3C/ABLIM1/NTN4/CXCR4/PTK2/MYL9/PAK2/SSH3/PDPK1/PARD6B/ILK/SEMA4C/PIK3R1/PIK3CA/RAC1/GSK3B/NFATC2/PLXNC1/PLXNB2/SRGAP2/NRP1/GNAI2/MAPK3/SSH2/L1CAM/SEMA7A/EFNA5/RAC2/EPHA2/CAMK2D/PIK3CD/PPP3CA/SSH1/SEMA6D/ARHGEF12/SEMA4A/PARD3/PIK3R3/NCK1/CFL2/NFATC3/WNT5A/PIK3CB/NCK2/MAPK1/PLXNB1/EPHA1/PAK1/NRAS	4.22279035818783
Human Diseases	Cancer: specific types	hsa05214	Glioma	31/1938	76/9376	1.97338547607409	EGFR/PDGFA/GADD45A/CDKN1A/KRAS/GADD45B/CALM2/IGF1R/CDKN2A/SOS1/PDGFB/PIK3R1/PIK3CA/SOS2/MAPK3/MDM2/BAX/CAMK1/CAMK1D/CAMK2D/RB1/PIK3CD/PIK3R3/PRKCB/DDB2/GADD45G/SHC1/ARAF/PIK3CB/MAPK1/NRAS	4.34895206926245
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	57/1938	170/9376	1.62214532871972	IGF2/TGFBR1/EGFR/WNT6/GADD45A/CDKN1A/KRAS/GADD45B/NFE2L2/HMOX1/MET/FZD5/WNT10A/IGF1R/CDKN2A/SOS1/GSTT1/WNT7A/SMAD4/WNT11/TCF7L1/BCL2L1/PIK3R1/PIK3CA/GSK3B/SOS2/GAB1/MAPK3/BAX/PBRM1/CSNK1A1/TGFB2/ACTB/SMAD3/RB1/PIK3CD/GSTM3/SMAD2/FZD1/BAD/TGFBR2/FZD6/PIK3R3/PRKCB/DDB2/GADD45G/ARID1B/SHC1/WNT5A/ARID1A/ARAF/PIK3CB/MAPK1/BRD7/DVL3/WNT9A/NRAS	4.17845046085185
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	42/1938	115/9376	1.76691344730112	EGFR/CDKN1A/AKAP13/JUND/GATA3/ITPR2/CREB5/CREB3L2/FOS/RXRA/ARRB1/NR4A2/GNA11/PLD1/WNK1/GNAQ/MMP14/ATF4/ARRB2/GNAI2/MAPK3/MAFB/GNA13/HBEGF/SGK1/CREB3/RXRB/MEF2A/PLCB2/PLCB1/PDE4A/PRKCB/ADCY9/ADCY7/PLD2/ATF6B/MEF2D/ARAF/MAPK1/PRKACB/SP1/VDR	4.22377493375085
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	65/1938	201/9376	1.56452002115326	HPGD/PDGFA/PLAU/GADD45A/CDKN1A/GADD45B/SPINT1/NUPR1/CSF1R/MET/RUNX1/FLT1/BCL2A1/FUT8/JMJD1C/CD14/JUP/SPI1/IGF1R/CEBPA/RXRA/PTK2/MITF/IGFBP3/BIRC3/FCGR1A/MMP9/BCL2L1/CD86/KLF3/ITGAM/MDM2/NCOR1/BAX/BCL6/RELA/CD40/RXRB/LYL1/MAX/PBX3/ELK4/FOXO1/CEBPB/BMI1/TGFBR2/FLI1/BIRC2/NFKBIZ/ASPSCR1/DDX5/PER2/NR4A3/IL6/DDB2/GADD45G/AFF1/BMP2K/CDK9/CCNT2/HHEX/ATF1/NFKB1/SP1/ETV6	4.12960752836265
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	46/1938	130/9376	1.71189965864888	TGFBR1/EGFR/KRAS/NFKBIA/CREB5/EDNRB/CREB3L2/FOS/SOS1/ARRB1/MMP9/PIK3R1/PIK3CA/SOS2/COL4A5/ATF4/ARRB2/GNAI2/MAPK3/RELA/CREB3/EDN1/GNA15/PIK3CD/COL4A2/VEGFA/SMAD2/PLCB2/TGFBR2/PLCB1/PIK3R3/MAP2K7/MAP2K4/ADCY9/ADCY7/JUN/ATF6B/SHC1/GNB1/PIK3CB/MAPK1/NFKB1/PRKACB/GNB4/MAPK8/NRAS	4.17203510273755
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	21/1938	45/9376	2.25772273821809	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-F/HLA-DQA2/IL1B/CD86/HLA-E/TNF/HLA-DOA/IL1A/HLA-DRB5/IL6/FAS	4.31679586775861
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	29/1938	71/9376	1.97607523365165	IRF1/KRAS/STAT1/FOS/STAT3/SOS1/SOCS3/PIK3R1/PIK3CA/GSK3B/SOS2/MAPK3/RELA/CISH/SOCS6/GALT/SOCS2/STAT5B/PIK3CD/STAT5A/FOXO3/SOCS1/PIK3R3/SHC1/PIK3CB/MAPK1/NFKB1/MAPK8/NRAS	4.21394357964699
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	29/1938	72/9376	1.94862974429538	NFKBIA/IFIH1/TRADD/TNF/TRAF3/ADAR/RELA/ZNFX1/NFKBIB/TBK1/CXCL10/DHX58/RIPK1/IFNB1/IRF3/FADD/MAP3K1/MAP3K7/CASP8/IKBKB/CYLD/CHUK/TANK/MAVS/IKBKG/IKBKE/OTUD5/NFKB1/MAPK8	4.12441704251991
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	46/1938	133/9376	1.67328538063425	TYROBP/HLA-B/KRAS/FCER1G/HLA-A/IFNGR1/ITGB2/FCGR3A/SOS1/CD48/ICAM1/HCST/VAV2/TNFSF10/IFNAR1/PIK3R1/PIK3CA/PTPN6/RAC1/SYK/LCP2/NFATC2/SOS2/HLA-E/TNF/MAPK3/LAT2/RAC2/VAV3/VAV1/PIK3CD/PPP3CA/IFNGR2/ITGAL/IFNB1/PIK3R3/PRKCB/SHC1/TNFRSF10A/ARAF/PIK3CB/MAPK1/BID/FAS/PAK1/NRAS	3.99165470597836
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	43/1938	122/9376	1.70518871914598	PRKAB2/RAB2A/CREB5/IRS2/IGF1R/ADIPOR1/CREB3L2/SCD5/CD36/PDPK1/ULK1/PRKAG2/PPP2R3A/PFKP/PIK3R1/PIK3CA/CAB39/PPP2R2A/PPP2R2B/RHEB/PPP2R5E/INSR/FBP1/RAB11B/CREB3/PPP2CB/RAB14/PPP2CA/PIK3CD/EIF4EBP1/FOXO1/FOXO3/TSC2/CAMKK2/TBC1D1/TSC1/PIK3R3/MAP3K7/PIK3CB/STK11/RAB10/PPP2R3C/CRTC2	4.00179614576975
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	50/1938	150/9376	1.61265909872721	TGFBR1/EGFR/WNT6/GADD45A/CDKN1A/KRAS/GADD45B/MET/FZD5/WNT10A/JUP/SOS1/RXRA/WNT7A/SMAD4/WNT11/FGFR2/TCF7L1/CDKN2B/PIK3R1/PIK3CA/GSK3B/FGF1/SOS2/GAB1/MAPK3/BAX/RXRB/CDH1/CSNK1A1/TGFB2/SMAD3/RB1/PIK3CD/SMAD2/FZD1/TGFBR2/FZD6/PIK3R3/CTNNA1/DDB2/GADD45G/SHC1/WNT5A/ARAF/PIK3CB/MAPK1/DVL3/WNT9A/NRAS	3.86093268343441
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	20/1938	44/9376	2.19908058917347	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-F/HLA-DQA2/IL1B/CD86/HLA-E/TNF/HLA-DOA/IL1A/HLA-DRB5/FAS	4.06931944211479
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	19/1938	41/9376	2.24198947871832	EGFR/CDKN1A/KRAS/CDKN2A/TYMP/MMP9/DAPK1/MAPK3/MDM2/HBEGF/CDH1/RB1/THBS1/VEGFA/DAPK3/ARAF/MAPK1/RASSF1/NRAS	4.06805786288767
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	15/1938	29/9376	2.50240204974912	RASSF2/LATS2/RASSF4/TEAD1/STK3/AJUBA/MOB1A/RASSF6/WWC1/CSNK1E/SAV1/WWTR1/RASSF1/WTIP/PAK1	4.13602811821763
Human Diseases	Immune disease	hsa05310	Asthma	16/1938	32/9376	2.41898864809082	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/PRG2/FCER1G/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-DQA2/TNF/CD40/HLA-DOA/IL10/HLA-DRB5	4.1041377884062
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	29/1938	75/9376	1.87068455452356	PMAIP1/CDKN1A/CDKN2A/GSTT1/PDPK1/BIRC3/MAP3K5/BCL2L1/PIK3R1/PIK3CA/BBC3/MAPK3/MDM2/ERCC1/BAX/XIAP/PIK3CD/GSTM3/CASP9/BAD/BIRC2/FADD/PIK3R3/CASP8/PIK3CB/MAPK1/REV3L/BID/FAS	3.86421326872227
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	29/1938	75/9376	1.87068455452356	SERPINE1/PMAIP1/GADD45A/CDKN1A/GADD45B/PERP/CDKN2A/SESN1/IGFBP3/PPP1R13L/BCL2L1/BBC3/RRM2B/ZMAT3/CCNG2/MDM2/BAX/PPM1D/CD82/THBS1/CASP9/TSC2/DDB2/CASP8/MDM4/GADD45G/TNFRSF10A/BID/FAS	3.86421326872227
Human Diseases	Cancer: specific types	hsa05218	Melanoma	28/1938	73/9376	1.85566252456282	EGFR/PDGFA/GADD45A/CDKN1A/KRAS/GADD45B/MET/IGF1R/CDKN2A/PDGFB/MITF/PIK3R1/PIK3CA/FGF1/MAPK3/MDM2/BAX/CDH1/RB1/PIK3CD/BAD/PIK3R3/DDB2/GADD45G/ARAF/PIK3CB/MAPK1/NRAS	3.74616471332298
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	11/1938	19/9376	2.80093422410515	HEXB/IDS/HEXA/GNS/HGSNAT/NAGLU/GUSB/HPSE/GLB1/ARSB/GALNS	4.01089021326291
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	27/1938	70/9376	1.86607695709863	ACSL3/PRKAB2/NFKBIA/TNFRSF1A/IRS2/ADIPOR1/STAT3/RXRA/CD36/SOCS3/TRADD/PRKAG2/TNF/RELA/RXRB/NFKBIB/TNFRSF1B/NFKBIE/CAMKK2/IKBKB/CHUK/PPARA/IKBKG/ACSL5/STK11/NFKB1/MAPK8	3.71243122931325
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	38/1938	110/9376	1.67130124777184	SERPINE1/EGFR/CDKN1A/EPAS1/IFNGR1/HMOX1/FLT1/IGF1R/STAT3/CYBB/CREBBP/PFKP/PIK3R1/PIK3CA/MAPK3/HIF1A/IL6R/INSR/RELA/EP300/EDN1/CAMK2D/EIF4E2/PIK3CD/IFNGR2/VEGFA/EIF4EBP1/HK3/PIK3R3/PRKCB/TLR4/LTBR/IL6/PIK3CB/MAPK1/NFKB1/RBX1/CUL2	3.61494826755005
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	17/1938	37/9376	2.22285443338075	GADD45A/CDKN1A/KRAS/GADD45B/RXRA/CCDC6/TCF7L1/MAPK3/BAX/RXRB/CDH1/TFG/DDB2/GADD45G/TPM3/MAPK1/NRAS	3.80416963132718
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	24/1938	60/9376	1.93519091847265	HSPB1/KRAS/PTK2/PIK3R1/PIK3CA/RAC1/NFATC2/MAPK3/MAPKAPK3/RAC2/PTGS2/PIK3CD/PPP3CA/PXN/VEGFA/CASP9/BAD/PIK3R3/PRKCB/MAPKAPK2/SPHK1/PIK3CB/MAPK1/NRAS	3.70933112405627
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	35/1938	99/9376	1.71039601380159	KRT18/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGB2/HLA-DQA1/FCGR3A/HLA-DMA/HLA-DQB1/HLA-DMB/KRT14/C1QA/C1QB/C5AR1/FPR3/ICAM1/KRT19/HLA-DQA2/FCGR1A/C1QC/C3AR1/FCGR2A/ITGAM/PTAFR/C2/FPR1/HLA-DOA/KRT23/C3/IL10/KRT17/ITGAL/SELPLG/HLA-DRB5	3.62701016221322
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	21/1938	50/9376	2.03195046439628	ITGB2/MET/ICAM1/CD36/IL18/CD81/IL1B/LRP1/TNF/CD40/MYD88/SDC2/TGFB2/THBS1/IL10/ITGAL/TLR2/THBS3/TLR4/IL6/SDC1	3.73448384424609
NA	NA	hsa04519	Cadherin signaling	111/1938	404/9376	1.32924623731723	KRT18/KRT8/KRT7/EGFR/WNT6/AMOTL2/TJP1/ACTN4/KRAS/LIMA1/ARPC2/NFKBIA/VIM/RRAS/MET/PKP2/FZD5/KRT14/ANKRD6/DAAM1/WNT10A/MRAS/CDH8/JUP/SHOC2/IGF1R/TMC4/ARPC5/PTK2/WNT7A/ARPC3/WNT11/KRT19/VAV2/TCF7L1/ADAM10/YWHAZ/CREBBP/LATS2/MPDZ/ACTR3/TAOK3/AMOTL1/VASP/LHFPL2/RAC1/GSK3B/PSENEN/TEAD1/NCSTN/CYFIP1/MYO1C/RRAS2/MAP2K3/STK3/NCKAP1L/MAPK3/AJUBA/ACTN1/MOB1A/RELA/TMC5/RAC2/CDH1/VAV3/EP300/TMC1/CSNK1A1/KRT23/ACTB/TAOK1/VAV1/YWHAH/KRT17/TMC7/YWHAG/FZD1/DSC2/CELSR2/ARPC1B/ARPC5L/VCL/WWC1/FZD6/PSEN1/CTNNA1/GABRE/PCDH1/APH1A/SAV1/IKBKB/WWTR1/CHUK/WNT5A/DSG2/PSEN2/IKBKG/MAPK1/NCKAP1/DVL3/NFKB1/MYO1G/TMC8/WTIP/VANGL1/MYO1D/APH1B/WNT9A/PCDH11Y/MAPK8/NRAS	3.45303760575374
Organismal Systems	Immune system	hsa04611	Platelet activation	42/1938	126/9376	1.61265909872721	SNAP23/VAMP8/MYL12B/MYL12A/FCER1G/ITGB1/ITGA2/ITPR2/FERMT3/RAP1B/PIK3R1/PIK3CA/FCGR2A/VASP/SYK/LCP2/GNAQ/GNAI2/MAPK3/TBXAS1/GNA13/PPP1R12A/BTK/ACTB/PIK3CD/PLCB2/ARHGEF12/PTGS1/PIK3R5/PLCB1/RAP1A/PIK3R3/ADCY9/PRKCI/TLN1/APBB1IP/ADCY7/PIK3CB/MAPK1/PRKACB/ITGB3/PRKG1	3.53400965298554
NA	NA	hsa03272	Virion - Hepatitis viruses	20/1938	48/9376	2.01582387340901	EGFR/CD63/LAMP2/CD9/CLDN4/TSG101/PDCD6IP/DPP4/CD81/IST1/CLDN19/CLDN23/CHMP1A/VPS4B/CHMP1B/LAMP1/TGOLN2/CLDN7/CLDN1/VPS4A	3.60146503464225
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	30/1938	83/9376	1.74866649259577	LCOR/PHC2/CREBBP/USP7/UBE2D3/AEBP2/UBE2D1/L3MBTL3/CSNK2B/PHC1/ASXL2/EP300/USP16/MAX/SCML1/FBRS/FOXK2/UBE2D4/PCGF5/FOXK1/BMI1/SKP1/DCAF7/YAF2/KDM2A/MBD6/PHF1/EZH1/KDM2B/CBX6	3.49690562277155
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	37/1938	109/9376	1.64224917393321	PRKAB2/NFKBIA/PTPRF/CREB5/TNFRSF1A/IRS2/CREB3L2/STAT3/CD36/PDPK1/MLXIP/SOCS3/PRKAG2/PIK3R1/PIK3CA/GSK3B/PPP1R3D/TNF/INSR/SLC27A1/PYGB/RELA/PTPN1/CREB3/GFPT1/PIK3CD/FOXO1/PIK3R3/PRKCB/IL6/IKBKB/PPARA/PIK3CB/NFKB1/CRTC2/RPS6KA1/MAPK8	3.44256111835089
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	34/1938	98/9376	1.67848191908342	ITPR2/CALM2/INPPL1/CDS1/PIP5K1B/PLCD3/CDIPT/SYNJ2/PIK3R1/PIK3CA/DGKH/IPMK/PIP4K2A/DGKA/PI4K2A/ITPKC/OCRL/PIK3CD/PLCB2/INPP5D/PLCB1/PIK3R3/PRKCB/MTM1/SACM1L/PIK3C3/PIP5K1C/PIK3C2B/MTMR14/PIK3CB/CDS2/PIP4K2C/PI4KB/INPP1	3.44634356453515
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	47/1938	148/9376	1.53638468189552	EGFR/WNT6/GADD45A/CDKN1A/KRAS/GADD45B/FZD5/WNT10A/NCOA3/IGF1R/FOS/SOS1/WNT7A/WNT11/TCF7L1/NOTCH3/NCOA1/JAG1/PIK3R1/PIK3CA/GSK3B/FGF1/SOS2/NOTCH2/MAPK3/NFKB2/BAX/NOTCH1/HES1/CSNK1A1/RB1/PIK3CD/FZD1/FZD6/PIK3R3/DDB2/GADD45G/JUN/SHC1/WNT5A/ARAF/PIK3CB/MAPK1/DVL3/SP1/WNT9A/NRAS	3.35728236382474
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	47/1938	149/9376	1.52607337530562	EGFR/PDGFA/KRAS/FCER1G/RRAS/CYTH3/RALGDS/MRAS/SOS1/PDGFB/CYTH2/PIP5K1B/PLD1/PIK3R1/PIK3CA/DGKH/SYK/SOS2/RRAS2/GAB1/MAPK3/RHEB/RALA/INSR/DGKA/GNA13/PIK3CD/PLCB2/TSC2/TSC1/PIK3R5/PLCB1/ARF6/PIK3R3/CYTH4/ADCY9/CYTH1/ARF1/LPAR6/ADCY7/PLD2/PIP5K1C/SHC1/SPHK1/PIK3CB/MAPK1/NRAS	3.30402735304511
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	15/1938	33/9376	2.19908058917347	SNAP23/VAMP8/STX7/STX3/STX4/STX11/VAMP7/SNAP29/STX17/VAMP5/STX18/USE1/STX5/STX6/GOSR1	3.52205882883585
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	69/1938	238/9376	1.40260686317871	IL6ST/EGFR/RPS4Y1/JAK1/NFKBIA/C1QA/C1QB/STAT1/C5AR1/TNFRSF1A/TLR3/FOS/STAT3/IFIH1/CYBB/IFNAR1/IL1B/C1QC/C3AR1/CASP1/PIK3R1/PIK3CA/FCGR2A/SYK/TNF/NRP1/MAPK3/IL6R/C2/TRAF3/STAT2/HBEGF/ADAR/RELA/MYD88/ADAM17/NFKBIB/TBK1/CXCL10/PIK3CD/C3/RPS27L/OAS2/IFNB1/TLR2/MX2/IRF3/PIK3R3/PRKCB/TAB2/TLR4/MAP3K7/IL6/EIF2AK2/TLR7/IKBKB/JUN/CHUK/OAS1/MAVS/IKBKG/PIK3CB/MAPK1/IKBKE/NFKB1/NLRP3/TLR8/IRAK4/MAPK8	3.21128250428587
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	20/1938	50/9376	1.93519091847265	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/CXCR4/TNFSF13B/HLA-DQA2/CD86/CCL28/CD40/HLA-DOA/IL10/HLA-DRB5/LTBR/IL6/IL15RA	3.38432463264111
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	44/1938	139/9376	1.53144605058987	KRT18/CTSD/EGFR/KRAS/ITPR2/HSPA1B/KRT14/CREB5/NCOA3/CALM2/CREB3L2/FOS/SOS1/KRT19/MMP9/NCOA1/PIK3R1/PIK3CA/GNAQ/SOS2/HSPA1A/ATF4/HSPA6/GNAI2/MAPK3/HBEGF/CREB3/KRT23/PIK3CD/KRT17/PLCB2/PLCB1/HSP90AA1/PIK3R3/ADCY9/ADCY7/JUN/ATF6B/SHC1/PIK3CB/MAPK1/PRKACB/SP1/NRAS	3.22207429212205
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	18/1938	44/9376	1.97917253025612	ARHGDIB/CREB5/CREB3L2/STX4/RAB5A/DYNC1I2/RAB5C/RAB11A/DYNC1LI2/RAB11B/DCTN1/CREB3/RAB5B/DCTN6/DYNC1H1/ARHGDIA/ADCY9/PRKACB	3.32301752737282
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	104/1938	388/9376	1.29677741959508	APOE/CAPN2/WNT6/WIPI1/KRAS/SLC39A8/ITPR2/RTN4/FZD5/WNT10A/SLC11A2/CALM2/TNFRSF1A/IRS2/MME/TUBA1A/WNT7A/WNT11/TUBB2A/CYBB/ULK1/IL1B/LRP1/SLC39A13/LPL/MAP3K5/ADAM10/ATF6/PIK3R1/PIK3CA/GSK3B/PSENEN/GNAQ/NCSTN/ATF4/TNF/CAPN1/MAPK3/PSMD7/INSR/RB1CC1/CSNK2B/SLC39A11/RELA/BECN1/MCU/ADAM17/CSNK1A1/PTGS2/RTN3/CASP7/IL1A/KIF5B/WIPI2/PIK3CD/PPP3CA/NOX4/PSMA5/MT-ND4L/APP/FZD1/CASP9/PSMA3/PLCB2/BAD/FADD/EIF2AK3/PSMD8/PLCB1/FZD6/PIK3R3/MAP2K7/NDUFA13/PSEN1/CSNK1E/TUBA4A/IL6/EIF2AK2/SLC39A7/APH1A/CASP8/ATG14/PIK3C3/IKBKB/ULK2/CHUK/WNT5A/PSEN2/ARAF/IKBKG/PIK3CB/MAPK1/XBP1/DVL3/NFKB1/PSMD1/BID/PSMC6/FAS/PSMD9/APH1B/WNT9A/MAPK8/NRAS	3.04754146174314
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	36/1938	110/9376	1.5833380242049	TGFBR1/FBN1/SKIL/BMPR2/EMP3/TGIF1/HAMP/SMAD4/SMURF2/ID3/CDKN2B/SMAD7/CREBBP/LTBP1/TNF/MAPK3/BAMBI/NCOR1/E2F4/PPP2CB/EP300/INHBA/TGFB2/PPP2CA/SMAD3/NOG/THBS1/SMAD2/SKP1/TGFBR2/SMURF1/THSD4/SKI/MAPK1/RBX1/SP1	3.14126748161846
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	21/1938	55/9376	1.84722769490571	HEXB/ASAH1/PSAP/HEXA/UGCG/ACER3/DEGS1/ARSA/SMPD1/NEU1/SGMS2/B4GALT5/SGMS1/KDSR/CERS6/SPTLC3/SPTLC2/GALC/SGPL1/SPHK1/GLB1	3.2165082690407
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	27/1938	78/9376	1.67468444867826	INPPL1/PIP5K1B/PLCD3/CDIPT/SYNJ2/PIK3CA/IPMK/PIP4K2A/ISYNA1/PI4K2A/ITPKC/OCRL/PIK3CD/PLCB2/INPP5D/PLCB1/MTM1/SACM1L/FIG4/PIK3C3/PIP5K1C/PIK3C2B/MTMR14/PIK3CB/PIP4K2C/PI4KB/INPP1	3.05413104681069
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	33/1938	101/9376	1.58072525518806	WNT6/KRAS/FZD5/EDNRB/WNT10A/CALM2/CREB3L2/WNT7A/WNT11/MITF/TCF7L1/CREBBP/GSK3B/GNAQ/GNAI2/MAPK3/CREB3/EP300/EDN1/CAMK2D/FZD1/PLCB2/PLCB1/FZD6/PRKCB/ADCY9/ADCY7/WNT5A/MAPK1/DVL3/PRKACB/WNT9A/NRAS	2.99508311511774
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	81/1938	298/9376	1.31502067446548	IL6ST/TGFBR1/TNFRSF12A/CSH1/CXCR6/IL1RAP/CXCL2/IL32/CSH2/BMPR2/IFNGR1/CSF1R/CXCL16/CSF2RA/CCL3/CSF3R/TNFRSF21/CXCR4/CXCL3/OSMR/TNFRSF1A/TNFSF13B/EBI3/CD4/TNFSF10/CSF2RB/IL18/IFNAR1/IL1B/CCL5/ACKR3/TNFRSF14/IL1RN/IL13RA1/CCL18/OSM/IL4R/TNF/TNFSF12/IL17RE/IL6R/CCL28/INHA/GDF15/IFNL2/IL2RG/CD40/CCL20/IFNL1/CCL4/INHBA/IL10RB/IL1A/TGFB2/CXCL9/CXCL10/TNFRSF1B/IL10/IFNGR2/XCR1/TNFRSF10C/TNFSF15/IFNB1/TGFBR2/IL27/IFNL3/IL7R/CCR1/LTBR/IL6/IL17RC/IL27RA/TNFRSF10A/CTF1/IL31RA/CSHL1/FAS/CCL7/IL11RA/IL15RA/CCL3L3	2.82089250795657
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	22/1938	62/9376	1.71670162122574	KRAS/PRKAB2/HSPA1B/IRS2/IGF1R/PRKAG2/PIK3R1/PIK3CA/HSPA1A/HSPA6/INSR/PIK3CD/FOXO1/FOXO3/PIK3R3/ADCY9/SOD2/ADCY7/PIK3CB/PRKACB/EIF4EBP2/NRAS	2.89001803109748
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	32/1938	100/9376	1.54815273477812	IL6ST/CXCL2/CSF1R/CCL3/CXCR4/CXCL3/TNFRSF1A/TNFSF10/IL18/CCL5/ACKR3/TNFRSF14/CCL18/TNF/IL6R/CCL28/IL2RG/CCL20/CCL4/IL10RB/CXCL9/CXCL10/TNFRSF1B/IL10/XCR1/TNFRSF10C/CCR1/LTBR/IL6/TNFRSF10A/CCL7/CCL3L3	2.81290880664029
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	14/1938	34/9376	1.99210829842773	PRKAB2/PRKAG2/BHLHE40/FBXL3/FBXW11/NR1D2/NFIL3/SKP1/CSNK1D/PER2/CSNK1E/CRY1/CLOCK/RBX1	2.95810133109208
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	43/1938	144/9376	1.44467377594313	WIPI1/ITPR2/ATXN1/ULK1/MAP3K5/PIK3R1/PIK3CA/GNAQ/ATXN2/PSMD7/RB1CC1/ATXN2L/VLDLR/SLC1A6/BECN1/MCU/RBPJ/WIPI2/PIK3CD/PSMA5/PUM1/GTF2B/PSMA3/PLCB2/PSMD8/PLCB1/PIK3R3/PRKCB/CIC/ATXN1L/ATG14/PIK3C3/ULK2/ATXN10/KAT5/PIK3CB/XBP1/PSMD1/TBP/PSMC6/SP1/PSMD9/MAPK8	2.74479114482211
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	30/1938	93/9376	1.56063783747795	EGFR/KRAS/ITPR2/CALM2/SOS1/GNA11/PLD1/GNAQ/SOS2/MAP2K3/MMP14/ATF4/MAPK3/HBEGF/MAP3K2/CAMK2D/PLCB2/PLCB1/PRKCB/MAP2K7/MAP2K4/ADCY9/MAP3K1/ADCY7/JUN/PLD2/MAPK1/PRKACB/MAPK8/NRAS	2.7734104114223
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	51/1938	178/9376	1.38616203429923	WNT6/FZD5/ANKRD6/DAAM1/WNT10A/SFRP1/WNT7A/SMAD4/WNT11/TCF7L1/TBL1XR1/CREBBP/RAC1/GSK3B/NFATC2/TLE6/BAMBI/FBXW11/TLE1/TLE2/CSNK2B/CTBP2/RAC2/EP300/CSNK1A1/CAMK2D/PORCN/SMAD3/PPP3CA/TLE4/MMP7/FZD1/CELSR2/PLCB2/SKP1/PLCB1/FZD6/PRKCB/PSEN1/CSNK1E/MAP3K7/CBY1/NFATC3/JUN/WNT5A/DVL3/PRKACB/RBX1/VANGL1/WNT9A/MAPK8	2.65501702174333
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	16/1938	42/9376	1.84303896997395	FTL/FTH1/ACSL3/GPX4/SLC39A8/HMOX1/LPCAT3/SLC11A2/MAP1LC3B/SLC40A1/CYBB/SAT1/PRNP/PCBP1/SLC3A2/ACSL5	2.79494222615903
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/1938	32/9376	1.96542827657379	WIPI1/ATG9B/GABARAPL2/GABARAPL1/GABARAP/BECN1/PPP2CB/ATG3/WIPI2/PPP2CA/ATG4D/PIK3C3/ULK2	2.79230610985745
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/1938	54/9376	1.70225127087872	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQA1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-F/HLA-DQA2/CD86/HLA-E/CD40/HLA-DOA/IL10/HLA-DRB5/FAS	2.64161366175353
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	24/1938	73/9376	1.5905678781967	TSG101/CXCR4/PDCD6IP/CD4/SERINC3/CREBBP/SAMHD1/VPS4B/BST2/SUPT5H/AFF4/ELL/MDFIC/FEZ1/SUPT4H1/EP300/HGS/ELL2/MX2/CDK9/CCNT2/MAP1S/KAT2B/VPS4A	2.58555736942303
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	28/1938	89/9376	1.52206027295602	SPP1/FN1/ITGB6/ITGB4/LAMB4/ITGB1/CD47/ITGA2/ITGA6/CD44/SDC4/ITGA3/CD36/LAMA5/LAMC2/AGRN/LAMB3/LAMB2/COL4A5/NPNT/LAMA3/LAMC1/DAG1/THBS1/COL4A2/THBS3/SDC1/ITGB3	2.52587796461255
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	12/1938	30/9376	1.93519091847265	FOLR1/IL1B/TNF/SLC46A1/RELA/ABCC3/IL6/IKBKB/CHUK/IKBKG/NFKB1/FOLR2	2.61868015692317
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	40/1938	140/9376	1.38227922748047	SPP1/SERPINE1/TGFBR1/KRAS/PRKAB2/RRAS/ITPR2/MRAS/CALM2/MAP1LC3B/SMAD4/PRKAG2/NOTCH3/JAG1/GNAQ/RRAS2/GNAI2/MAPK3/SLC8A1/GNA13/BECN1/CDH1/SMAD3/KLF2/MEF2A/SMAD2/PLCB2/PIK3R5/PLCB1/ADCY9/ADCY7/PIK3C3/MEF2D/GNB1/SPHK1/MAPK1/PRKACB/SLC9A1/GNB4/NRAS	2.32614719618359
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	14/1938	38/9376	1.78241268806692	HEXB/HEXA/GALE/AMDHD2/GNPDA1/UGP2/GALT/PGM2/GFPT1/RENBP/PMM2/HK3/GMPPA/UAP1	2.46680707683044
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	14/1938	38/9376	1.78241268806692	NEDD4L/KRAS/PDPK1/PIK3R1/PIK3CA/MAPK3/INSR/SGK1/ATP1B1/PIK3CD/PIK3R3/PRKCB/PIK3CB/MAPK1	2.46680707683044
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	24/1938	76/9376	1.52778230405736	ACSL3/UBC/ACOX1/SCD5/RXRA/CYP27A1/CD36/PDPK1/LPL/ILK/SLC27A1/PLIN2/RXRB/FABP5/OLR1/FABP4/GK/ACADL/FABP3/PPARA/ME3/ACSL5/FABP7/ACADM	2.358058549022
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	8/1938	18/9376	2.15021213163628	HEXB/HEXA/FUCA2/MAN2B2/NEU1/AGA/MANBA/GLB1	2.49319997342522
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	27/1938	89/9376	1.4677009774933	EGFR/PDGFA/TJP1/KRAS/ITPR2/SOS1/TUBA1A/PDGFB/TUBB2A/GNA11/GNAQ/SOS2/ADRB1/GNAI2/MAPK3/MAP3K2/PLCB2/CSNK1D/PLCB1/PRKCB/ADCY9/TUBA4A/ADCY7/MAPK1/PRKACB/PRKG1/NRAS	2.26287203657347
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	43/1938	155/9376	1.34214854023103	EGFR/WNT6/CDKN1A/HSD3B1/ITPR2/FZD5/CREB5/WNT10A/CDKN2A/CREB3L2/WNT7A/WNT11/RAP1B/TCF7L1/GNA11/CDKN2B/GSK3B/GNAQ/AHR/ATF4/GNAI2/MAPK3/CREB3/CAMK2D/RB1/NCEH1/FZD1/PLCB2/USP8/ASH2L/PLCB1/RAP1A/FZD6/ADCY9/ADCY7/ATF6B/PDE8A/WNT5A/MAPK1/DVL3/PRKACB/SP1/WNT9A	2.19243116595615
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	16/1938	47/9376	1.64697099444481	IRS2/SOCS3/PIK3R1/PIK3CA/TNF/MAPK3/INSR/SOCS2/PIK3CD/HK3/SOCS1/PIK3R3/IKBKB/PIK3CB/MAPK1/MAPK8	2.26960683362924
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	57/1938	217/9376	1.27080509623204	EGFR/KRAS/KLF4/CREB5/CREB3L2/FOS/STAT3/SOS1/RXRA/GSTT1/KLF5/ARRB1/JAG1/PIK3R1/PIK3CA/SOS2/NOTCH2/AHR/KPNA6/ADRB1/ATF4/ARRB2/GNAI2/MAPK3/MIR29A/BCL6/RELA/CREB3/KPNA1/RXRB/KPNA3/XIAP/STAT5B/RB1/PIK3CD/STAT5A/GSTM3/VEGFA/EIF4EBP1/BAD/HSP90AA1/PIK3R3/PRKCB/ADCY9/ADCY7/JUN/ATF6B/PPARA/PIK3CB/MAPK1/IKBKE/PAQR7/NFKB1/PRKACB/RPS6KA1/NRAS/VDR	2.06014177144404
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	18/1938	56/9376	1.55506413091552	SPOPL/SMURF2/ARRB1/GSK3B/SPOP/ARRB2/KIF3A/FBXW11/IQCE/CSNK1A1/CUL3/GLI3/CSNK1D/CSNK1E/SMURF1/GAS1/PRKACB/HHAT	2.12649153549694
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	13/1938	37/9376	1.69982986082057	APOL1/ICAM1/IL18/IL1B/GNAQ/TNF/MYD88/IL10/PLCB2/PLCB1/PRKCB/IL6/FAS	2.1770960066517
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	8/1938	20/9376	1.93519091847265	CYB5R1/UGP2/CMAS/GMPPA/UAP1/GMDS/CYB5R4/CYB5R3	2.13700043024733
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	115/1938	480/9376	1.15909872721018	CAPN2/PINK1/WNT6/WIPI1/KRAS/GPR37/SQSTM1/UBC/UBE2J1/ITPR2/FZD5/WNT10A/CALM2/MAP1LC3B/TNFRSF1A/UBE2L6/TUBA1A/WNT7A/RAB5A/WNT11/TUBB2A/CYBB/ATXN1/ULK1/IL1B/MAP3K5/BCL2L1/PRNP/ATF6/RAB1A/OPTN/RAC1/GSK3B/GNAQ/GPX1/MAP2K3/UBE2G1/ATF4/TNF/ATXN2/UBA7/CAPN1/MAPK3/PSMD7/RB1CC1/CSNK2B/BAX/ATXN2L/RELA/DCTN1/MFN2/BECN1/DCTN6/ACTR10/ACTR1A/DAXX/MCU/CSNK1A1/PTGS2/CAMK2D/CASP7/IL1A/KIF5B/TBK1/WIPI2/TNFRSF1B/PPP3CA/NOX4/PSMA5/MT-ND4L/APP/FZD1/CASP9/PSMA3/PLCB2/BAD/FADD/EIF2AK3/PSMD8/PLCB1/FZD6/PRKCB/MAP2K7/BDNF/NDUFA13/PSEN1/CSNK1E/TUBA4A/IL6/ATXN1L/CASP8/ATG14/FIG4/PIK3C3/ULK2/CHMP2B/TANK/WNT5A/PSEN2/ARAF/SPG11/LRRK2/MAPK1/XBP1/DVL3/NFKB1/PSMD1/BID/PSMC6/FAS/PSMD9/WNT9A/UBB/MAPK8/NRAS	1.82651975781096
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	41/1938	154/9376	1.28803291651589	EGFR/RCAN1/CDKN1A/KRAS/PRKAB2/MYL6/ITPR2/CALM2/PPP1R12B/FOS/MYL9/PRKAG2/GNAQ/NFATC2/CACNG4/CACNA2D3/GNAI2/MAPK3/PPP1R12A/KCNJ2/CAMK1/CAMK1D/PPP1R12C/PTGS2/CAMK2D/ACTB/PPP3CA/PLCB2/RGS2/CAMKK2/OXTR/PIK3R5/PLCB1/PRKCB/ADCY9/ADCY7/NFATC3/JUN/MAPK1/PRKACB/NRAS	1.83960406666614
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/1938	51/9376	1.51779679880208	TJP1/ATP6V0E1/ATP6V0D1/TJP2/ATP6V1D/ATP6V1E1/ATP6V1G1/TCIRG1/ATP6AP1/ATP6V1H/ATP6V1C1/ATP6V0B/ACTB/ADCY9/ARF1/PRKACB	1.89258095945484
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	20/1938	67/9376	1.4441723272184	KRAS/ITPR2/CALM2/RAP1B/CREBBP/GNAQ/ATF4/MAPK3/EP300/CAMK2D/PPP3CA/PLCB2/PLCB1/RAP1A/PRKCB/ARAF/MAPK1/PRKACB/RPS6KA1/NRAS	1.86239510468706
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	19/1938	63/9376	1.45907251789605	WNT6/GADD45A/CDKN1A/GADD45B/FZD5/WNT10A/WNT7A/WNT11/TCF7L1/GSK3B/BAX/FZD1/GLI3/FZD6/DDB2/GADD45G/WNT5A/DVL3/WNT9A	1.86612703893589
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	18/1938	59/9376	1.47599307341135	MGLL/IRS2/PNPLA2/PIK3R1/PIK3CA/ADRB1/GNAI2/INSR/PTGS2/PIK3CD/PTGS1/FABP4/PIK3R3/ADCY9/ADCY7/PIK3CB/PRKACB/PRKG1	1.87207407287558
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/1938	21/9376	1.84303896997395	DSE/CHPF/CHPF2/B3GAT3/CHST11/B4GALT7/CHST14/CHST13	1.97410314138516
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	12/1938	36/9376	1.61265909872721	ST6GALNAC2/GALNT6/GALNT18/GALNT1/C1GALT1/B4GALT5/GALNT7/C1GALT1C1/B3GNT3/GALNT3/GCNT1/ST6GALNAC1	1.87988437210241
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	16/1938	52/9376	1.48860839882512	APOE/APOC1/LRPAP1/ABCA1/MYLIP/CYP27A1/CD36/LRP1/LIPA/LPL/NPC1/LCAT/NCEH1/STARD3/APOC2/VAPA	1.80341594356491
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	38/1938	144/9376	1.27668845315904	IL6ST/SKIL/WNT6/JAK1/KRAS/BMPR2/FZD5/KLF4/WNT10A/IGF1R/STAT3/WNT7A/SMAD4/WNT11/FGFR2/ID3/PIK3R1/PIK3CA/GSK3B/ISL1/MAPK3/ZFHX3/INHBA/SMAD3/PIK3CD/SMAD2/FZD1/PCGF5/BMI1/FZD6/PIK3R3/WNT5A/KAT6A/PIK3CB/MAPK1/DVL3/WNT9A/NRAS	1.70788577422789
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	41/1938	157/9376	1.26342082256973	PRKAB2/TNFRSF1A/IRS2/ADIPOR1/CEBPA/FOS/RXRA/IL1B/MAP3K5/MLXIP/SOCS3/PRKAG2/PIK3R1/PIK3CA/RAC1/GSK3B/ATF4/TNF/IL6R/INSR/BAX/RELA/CASP7/IL1A/PIK3CD/EIF2AK3/PIK3R3/NDUFA13/IL6/CASP8/IKBKB/JUN/MAP3K11/PPARA/PIK3CB/XBP1/BCL2L11/NFKB1/BID/FAS/MAPK8	1.69899639680862
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	19/1938	65/9376	1.41417797888386	SPP1/KRAS/ITPR2/ARRB1/GNA11/PIK3R1/PIK3CA/GNAQ/ARRB2/MAPK3/PIK3CD/KCNN4/PLCB2/PLCB1/PIK3R3/PRKCB/PIK3CB/MAPK1/NRAS	1.71033017137803
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	16/1938	53/9376	1.46052144790389	CLTB/ATP2B4/BDKRB2/GNAQ/AP2A2/RAB11A/SLC8A1/CLTC/ATP1B1/PLCB2/AP2B1/PLCB1/PRKCB/ADCY9/PRKACB/VDR	1.71610711408176
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	28/1938	104/9376	1.30253234897198	PLD3/LPCAT3/CDS1/PLD1/CDIPT/DGKH/LCAT/GDPD5/LPIN2/MBOAT2/PLA2G15/SGMS2/LPCAT1/DGKA/GPCPD1/MBOAT7/SGMS1/LPIN1/PNPLA6/LPCAT2/PGS1/LPCAT4/CHKB/CRLS1/ACHE/PLD2/MBOAT1/CDS2	1.58356616949454
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	24/1938	88/9376	1.31944835350408	SERPINE1/CLU/CD59/SERPING1/PLAU/F5/ITGB2/C1QA/C1QB/C5AR1/SERPINA1/PLAUR/BDKRB2/C1QC/C3AR1/ITGAX/A2M/CD55/ITGAM/C2/VSIG4/C3/SERPINE2/C4BPB	1.53679282527333
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	30/1938	115/9376	1.26208103378651	KRAS/ITPR2/CREB5/CREB3L2/FOS/GNA11/PIK3R1/PIK3CA/GNAQ/ATF4/GNAI2/MAPK3/KCNJ2/CREB3/CAMK2D/PIK3CD/PLCB2/PIK3R5/ACHE/PLCB1/PIK3R3/PRKCB/ADCY9/ADCY7/GNB1/PIK3CB/MAPK1/PRKACB/GNB4/NRAS	1.44341099378891
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/1938	60/9376	1.37076023391813	KRAS/ITPR2/IGF1R/GNA11/GNAQ/GNAI2/MAPK3/GNA13/PPP2CB/PPP2CA/PLCB2/PLCB1/PRKCB/ARAF/MAPK1/PRKG1/NRAS	1.47057937376144
NA	NA	hsa04382	Cornified envelope formation	53/1938	217/9376	1.1816257912333	KRT18/KRT8/COL17A1/KRT7/S100A10/ITGB4/TJP1/DST/S100A11/PLEC/ITGA6/PKP2/KRT14/CLDN4/UGCG/JUP/PRSS8/KRT19/LAMA5/PPP2R3A/CLDN19/LAMC2/CLDN23/S100A8/LAMB3/S100A16/PPL/PPP2R2A/COL4A5/S100A9/CAPN1/PPP2R2B/PPP2R5E/LAMA3/SLC27A1/CLDN7/ST14/PPP2CB/KRT23/S100A4/PPP2CA/COL4A2/KRT17/PCSK6/CLDN1/KDSR/SPTLC3/SPTLC2/S100A7/EVPL/DSG2/PPP2R3C/TMEM79	1.38171284254815
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/1938	17/9376	1.70752139865234	LAMP2/MYH9/LAMP1/DAG1/PCDH1/PCDH11Y	1.49033449622714
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/1938	37/9376	1.43831757454048	GALE/UGP2/GALT/CMAS/PGM2/GFPT1/PMM2/HK3/GMPPA/UAP1/GMDS	1.36355919431395
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	54/1938	226/9376	1.1559768760788	NFKBIA/RRAS/CREB5/ACOX1/ATP2B4/CALM2/CREB3L2/FOS/MYL9/VAV2/RAP1B/TIAM1/PLD1/CREBBP/PIK3R1/PIK3CA/RAC1/HCAR2/RRAS2/ADRB1/GNAI2/MAPK3/PDE10A/RELA/PPP1R12A/CREB3/RAC2/VAV3/EP300/EDN1/CAMK2D/ATP1B1/VAV1/PIK3CD/GLI3/SUCNR1/BAD/OXTR/RAP1A/PIK3R3/PDE4A/BDNF/ADCY9/ADCY7/JUN/PLD2/PPARA/PIK3CB/MAPK1/NFKB1/PRKACB/SLC9A1/MAPK8/PAK1	1.21154159229055
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1938	71/9376	1.29466998066832	EGFR/KRAS/MET/FGFR2/GLS/PFKP/PIK3R1/PIK3CA/MAPK3/HIF1A/SLC7A5/PIK3CD/SIRT6/HK3/PIK3R3/PIK3CB/MAPK1/SCO2/NRAS	1.2721587745921
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	25/1938	98/9376	1.23417788167899	HSD3B1/ITPR2/CREB5/ATP2B4/CALM2/CREB3L2/NR4A2/GNA11/GNAQ/ATF4/CREB3/CAMK1/DAGLB/CAMK1D/CAMK2D/ATP1B1/PLCB2/PLCB1/PRKCB/ADCY9/PRKD2/ADCY7/ATF6B/ATF1/PRKACB	1.18950470569816
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	22/1938	85/9376	1.25218235901172	UPP1/NME3/TYMP/GUK1/UCK2/RRM2B/TK2/DCTD/ENTPD4/LACC1/CDA/CTPS1/DGUOK/AMPD3/CMPK2/AK9/GMPR/GDA/AK3/ENTPD1/GMPR2/ENTPD6	1.19214031068456
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	14/1938	51/9376	1.32807219895182	PLD3/PAFAH1B2/PLA2G7/PLD1/LPCAT1/GDPD3/LPCAT2/GDPD1/LPCAT4/AGPS/PLD2/PAFAH1B1/TMEM86A/PAFAH2	1.19912521378879
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	40/1938	166/9376	1.16577766173051	ITPR2/GTF2I/CREB5/NPPB/EDNRB/ATP2B4/CALM2/IRS2/CREB3L2/MYL9/BDKRB2/GNA11/VASP/GNAQ/NFATC2/ADRB1/ATF4/GNAI2/MAPK3/SLC8A1/INSR/GNA13/PPP1R12A/CREB3/ATP1B1/PPP3CA/MEF2A/PLCB2/BAD/RGS2/PIK3R5/ADORA3/PLCB1/ADCY9/ADCY7/NFATC3/ATF6B/MEF2D/MAPK1/PRKG1	1.09997971462452
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	17/1938	65/9376	1.26531713900135	HSD3B1/ITPR2/CREB5/CREB3L2/GNA11/GNAQ/ATF4/CREB3/NCEH1/PLCB2/PLCB1/ADCY9/ADCY7/ATF6B/PDE8A/PRKACB/SP1	1.09561572790655
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1938	15/9376	1.61265909872721	HEXB/HEXA/B3GALT4/ST3GAL5/GLB1	1.21209827215734
Cellular Processes	Cell motility	hsa04814	Motor proteins	45/1938	194/9376	1.12221122849574	DYNLRB1/MYL12B/MYL12A/DYNLT1/MYL6/TNNT3/MYH9/MYO6/TUBA1A/MYL9/TUBB2A/TPM1/MYO5B/DYNC1I2/MYO9B/ACTG2/KIF13A/MYO1C/KIF3A/DYNC1LI2/KIFC3/DCTN1/CAPZA2/DCTN6/ACTR10/MYO5A/ACTR1A/ACTA1/ACTB/KIF5B/DYNC1H1/TNNT2/DYNLT3/CAPZA1/TUBA4A/CAPZB/KIF3B/TPM3/KIF13B/MYO5C/KIF16B/MYO9A/KIF1B/MYO1G/MYO1D	0.877966142011797
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	28/1938	117/9376	1.15780653241954	SMARCA1/BAZ2B/SRCAP/MORF4L2/RSF1/BAZ1A/MEAF6/MBD3/INO80C/BRD8/EPC1/PBRM1/ACTB/BAZ2A/MBD2/EPC2/BCL7B/GATAD2B/ARID1B/INO80D/ARID1A/KAT5/ZNHIT1/TFPT/VPS72/BRD7/CDK2AP2/SMARCA5	0.876738954720609
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	24/1938	99/9376	1.17284298089252	ITGB6/ITGB4/ITGB1/PRKAB2/LMNA/ITGA2/ITGA6/ITGA3/TPM1/PRKAG2/SGCE/CACNG4/TNF/CACNA2D3/SLC8A1/EDN1/DAG1/TGFB2/ACTB/TNNT2/IL6/SNTB2/TPM3/ITGB3	0.882470109607734
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1938	59/9376	1.22999422784279	UPP1/NME3/TYMP/UCK2/RRM2B/TK2/DCTD/ENTPD4/CDA/DPYD/CTPS1/CMPK2/AK9/ENTPD1/ENTPD6	0.904564068064567
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	45/1938	195/9376	1.11645629911884	ITGB2/FCGR3A/C5AR1/NCF2/CASP4/FPR3/CYBB/FCGR1A/CASP1/PIK3R1/PIK3CA/AQP9/FCGR2A/RAC1/NCF4/SYK/HDAC7/MAPK3/ITGAM/FPR1/HAT1/RELA/CLEC7A/RAC2/ACTB/GSDMD/HDAC10/PIK3CD/C3/SIGLEC9/ITGAL/SELPLG/PLCB2/TLR2/PLCB1/PIK3R3/PRKCB/TLR4/MAP3K7/TLR7/PIK3CB/MAPK1/NFKB1/ITGB3/TLR8	0.838821848807793
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/1938	46/9376	1.26208103378651	PSMB10/PSMB9/PSMB8/PSME1/PSMD7/PSMA5/PSMA3/PSME2/PSMD8/PSMD1/PSMC6/PSMD9	0.909511353332404
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	21/1938	86/9376	1.18136654906761	ITGB6/ITGB4/ITGB1/LMNA/ITGA2/ITGA6/PKP2/ITGA3/JUP/TCF7L1/SGCE/CACNG4/CACNA2D3/SLC8A1/DAG1/ACTB/DSC2/CTNNA1/SNTB2/DSG2/ITGB3	0.862448151627477
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	10/1938	38/9376	1.2731519200478	CD4/PTPRC/TAP1/BLNK/IL2RG/CD40/BTK/IL7R/CIITA/IKBKG	0.861199082914286
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	31/1938	133/9376	1.12764884347091	ITPR2/CREB5/CALM2/CREB3L2/FOS/ARRB1/PPP2R3A/GSK3B/GNAQ/PPP2R2A/ATF4/ARRB2/GNAI2/PPP2R2B/PPP2R5E/CREB3/PPP2CB/CAMK2D/KIF5B/PPP2CA/PPP3CA/PLCB2/PLCB1/PRKCB/ATF6B/GNB1/CLOCK/PRKACB/PPP2R3C/GNB4/MAPK8	0.756781776953707
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	19/1938	79/9376	1.16356415984115	CLTB/ATP6V0E1/SLC1A3/ATP6V0D1/ATP6V1D/STX3/ATP6V1E1/ATP6V1G1/TCIRG1/AP2A2/ATP6V1H/CLTC/ATP6V1C1/SLC1A6/ATP6V0B/SYT1/AP2B1/SLC6A2/SLC6A4	0.74518604773134
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/1938	107/9376	1.13036852714524	PRKAB2/ITPR2/CREB5/CALM2/CREB3L2/PRKAG2/CREBBP/PPP4C/PFKP/GNAQ/ATF4/FBP1/PYGB/CREB3/EP300/PHKB/SIK1/CAMK2D/PPP3CA/FOXO1/PLCB2/PLCB1/PPARA/PRKACB/CRTC2	0.692281369851572
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/1938	44/9376	1.20949432404541	HEXB/MAN1A1/HEXA/FUT8/MGAT4B/MGAT4A/MAN1B1/MGAT2/B4GALT3/MAN2A1/ALG13	0.710960825775943
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	12/1938	49/9376	1.18481076641183	GALNT6/GALNT18/GALNT1/C1GALT1/PLOD3/GALNT7/C1GALT1C1/LFNG/POFUT2/B4GALT3/MFNG/GALNT3	0.662046901363712
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	12/1938	49/9376	1.18481076641183	CREB5/CREB3L2/ATF4/GNAI2/RELA/CREB3/FOSB/BDNF/JUN/ATF6B/NFKB1/PRKACB	0.662046901363712
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	24/1938	105/9376	1.10582338198437	ITGB6/ITGB4/ITGB1/LMNA/ITGA2/ITGA6/ITGA3/TPM1/SGCE/CACNG4/ADRB1/TNF/CACNA2D3/SLC8A1/DAG1/TGFB2/ACTB/TNNT2/ADCY9/ADCY7/SNTB2/TPM3/PRKACB/ITGB3	0.556605423166792
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1938	14/9376	1.38227922748047	FUT8/B4GALT4/B3GNT2/B4GALT3	0.730625518472261
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	50/1938	227/9376	1.06563376567877	EGFR/KRAS/NFE2L2/NFKBIA/HMOX1/MET/NCF2/FOS/SOS1/GSTT1/PTK2/PDPK1/MAP3K5/PLD1/PIK3R1/PIK3CA/RAC1/SOS2/AHR/MAPK3/CBR1/HIF1A/PTPRJ/RELA/PTPN1/ABL2/PIK3CD/NOX4/MT-ND4L/GSTM3/VEGFA/FOXO3/BAD/PIK3R3/MAP2K7/MAP2K4/NDUFA13/PRKD2/SOD2/IKBKB/JUN/PLD2/CHUK/ARAF/IKBKG/PIK3CB/MAPK1/NFKB1/MAPK8/NRAS	0.51096114291126
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/1938	32/9376	1.20949432404541	PFKP/GALE/UGP2/GAA/GALT/PGM2/HK3/GLB1	0.605919978942878
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1938	78/9376	1.11645629911884	BTG2/BTG1/LSM1/PFKP/CNOT6L/XRN1/CNOT6/BTG3/PAN3/C1D/PARN/CNOT4/CNOT1/PATL1/DCP1B/EXOSC1/EXOSC6/XRN2	0.527169107621047
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	35/1938	158/9376	1.07170383143264	GADD45A/CDKN1A/GADD45B/CDKN2A/SMAD4/CDKN2B/YWHAZ/CREBBP/GSK3B/TFDP2/ANAPC13/MDM2/PPP2R5E/E2F4/RBL2/PPP2CB/EP300/TGFB2/CDC14A/YWHAH/PPP2CA/SMAD3/RB1/YWHAG/SMAD2/SKP1/FZR1/SMC1B/NIPBL/GADD45G/WEE1/MAD1L1/RBX1/CDKN2D/ATRX	0.463966892564855
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1938	28/9376	1.20949432404541	ATP6V0E1/ATP6V0D1/ATP6V1D/ATP6V1E1/ATP6V1G1/TCIRG1/ATP6V1C1	0.56666496463905
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/1938	154/9376	1.06812485759854	CREB5/ATP2B4/CALM2/CREB3L2/TPM1/PPP2R3A/GNAQ/PPP2R2A/CACNG4/ADRB1/ATF4/CACNA2D3/GNAI2/MAPK3/PPP2R2B/PPP2R5E/SLC8A1/CREB3/PPP2CB/CAMK2D/ATP1B1/PPP2CA/TNNT2/PLCB2/PIK3R5/PLCB1/ADCY9/ADCY7/ATF6B/TPM3/MAPK1/PRKACB/PPP2R3C/SLC9A1	0.435098760916848
Organismal Systems	Digestive system	hsa04978	Mineral absorption	14/1938	61/9376	1.11035544502529	FTL/FTH1/HMOX1/ATP2B4/SLC11A2/SLC40A1/SLC8A1/SLC46A1/CYBRD1/ATP1B1/MT2A/MT1F/SLC30A1/VDR	0.441368862915983
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	22/1938	99/9376	1.07510606581814	IL1RAP/ITPR2/CALM2/BDKRB2/IL1B/PIK3R1/PIK3CA/GNAQ/MAP2K3/PTGER4/CAMK2D/PIK3CD/PLCB2/PLCB1/PIK3R3/PRKCB/ADCY9/ADCY7/PRKCH/PIK3CB/PRKACB/MAPK8	0.383462827315827
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	17/1938	76/9376	1.08217913204063	ITPR2/CALM2/EZR/SLC4A2/GNAQ/GNAI2/KCNJ2/CAMK2D/ACTB/ATP1B1/PLCB2/PLCB1/PRKCB/ADCY9/ADCY7/PRKACB/SLC9A1	0.367165028781546
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1938	16/9376	1.20949432404541	HEXB/A4GALT/HEXA/GBGT1	0.428083772649848
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1938	30/9376	1.12886136910905	B3GALT4/PIGC/PIGP/PGAP3/PIGQ/MPPE1/DPM2	0.360831893909888
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1938	31/9376	1.09244648623456	PFKP/DERA/FBP1/H6PD/PGM2/TALDO1/IDNK	0.263157674832493
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1938	56/9376	1.03670942061035	MAN1A1/FUT8/MGAT4B/MGAT4A/MOGS/MAN1B1/MGAT2/ALG5/B4GALT3/DPM2/MAN2A1/ALG13	0.14063649198904
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	67/1938	323/9376	1.00354327815532	TIMP3/MARCKS/EGFR/PDGFA/EFNA1/PLAU/SOX4/CDKN1A/KRAS/BMPR2/VIM/HMOX1/MET/CD44/ERBB3/PIM1/FOXP1/MCL1/IRS2/CDKN2A/STAT3/SOS1/ZEB2/UBE2I/PDGFB/RDX/GLS/PDCD4/TPM1/EZR/MMP9/CREBBP/NOTCH3/PIK3R1/PIK3CA/TP63/SOS2/NOTCH2/MAPK3/MDM2/MIR29A/NOTCH1/EFNA5/ST14/EP300/PTGS2/TGFB2/FSCN1/PIK3CD/THBS1/BMF/VEGFA/BMI1/SOCS1/PIK3R3/PRKCB/MDM4/IKBKB/SHC1/PIK3CB/MAPK1/CRK/BCL2L11/NFKB1/RASSF1/ITGB3/NRAS	0.0330784145248209
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	23/1938	110/9376	1.0115770710198	KRAS/IGF1R/CPEB2/PIK3R1/PIK3CA/CPEB4/GNAI2/MAPK3/ANAPC13/PIK3CD/STK10/HSP90AA1/FZR1/PIK3R3/ADCY9/ADCY7/ARAF/PIK3CB/MAPK1/PRKACB/MAD1L1/RPS6KA1/MAPK8	0.0623423730630958
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1938	18/9376	1.07510606581814	ACSL3/OLAH/ACSL5/MECR	0.162799918511965
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1938	23/9376	1.05173419482209	MME/CTSA/LNPEP/PRCP/ATP6AP2	0.126794548804819
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1938	28/9376	1.03670942061035	A4GALT/ST3GAL6/B4GALT4/B3GNT2/B4GALT3/B3GNT3	0.0992959719881233
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	24/1938	116/9376	1.00096081989965	GLUL/SLC1A3/HOMER3/ITPR2/GLS/PLD1/GNAQ/GNAI2/MAPK3/SLC1A6/PPP3CA/PLCB2/PLCB1/SLC38A1/PRKCB/SLC38A2/ADCY9/SHANK2/ADCY7/PLD2/GNB1/MAPK1/PRKACB/GNB4	0.00531495911425699
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	10/1938	48/9376	1.00791193670451	PIK3R1/PIK3CA/ATP1B1/PIK3CD/PLCB2/HK3/PLCB1/PIK3R3/PRKCB/PIK3CB	0.0280506927859028
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1938	63/9376	0.998312775402559	POLD4/XPC/ERCC1/ERCC4/POLR2K/POLR2C/DDB2/RAD23B/GTF2H1/RBX1/RAD23A/RPA1/ERCC5	-0.00685855789510784
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/1938	93/9376	0.988403963736032	LYZ/ITPR2/CST3/ATP2B4/CALM2/BST1/SLC4A2/GNAQ/ADRB1/ATP1B1/KCNN4/PLCB2/PLCB1/PRKCB/ADCY9/ADCY7/PRKACB/SLC9A1/PRKG1	-0.0573642475691528
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1938	44/9376	0.989586265128061	GTF2I/GTF2A2/TAF13/TAF6/GTF2B/TAF3/GTF2H1/TAF5L/TBP	-0.0353410889660228
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	56/1938	275/9376	0.985188103949714	ITPR2/HSPA1B/C1QA/C1QB/CREB5/NCF2/CREB3L2/TUBA1A/TUBB2A/CYBB/IL1B/CCL5/C1QC/PRNP/PIK3R1/PIK3CA/RAC1/GSK3B/NCF4/HSPA1A/ATF4/HSPA6/TNF/MAPK3/PSMD7/CSNK2B/BAX/NOTCH1/CREB3/LAMC1/RAC2/MCU/IL1A/KIF5B/PIK3CD/PPP3CA/PSMA5/MT-ND4L/CASP9/PSMA3/BAD/EIF2AK3/PSMD8/PIK3R3/NDUFA13/TUBA4A/IL6/CAV2/ATF6B/PIK3CB/MAPK1/PRKACB/PSMD1/PSMC6/PSMD9/MAPK8	-0.127252663956215
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	27/1938	134/9376	0.974816320872418	MYL6/CALD1/ITPR2/NPPB/CALM2/MYH9/PPP1R12B/MYL9/GNA11/ACTG2/GNAQ/MAPK3/GNA13/PPP1R12A/EDN1/PPP1R12C/PLCB2/ARHGEF12/PLCB1/PRKCB/ADCY9/ADCY7/PRKCH/ARAF/MAPK1/PRKACB/PRKG1	-0.149872872741291
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1938	75/9376	0.967595459236326	ITPR2/CREB5/CREB3L2/GNAQ/GPX1/ATF4/CREB3/ATP1B1/PLCB2/PLCB1/PRKCB/ADCY9/ADCY7/ATF6B/PRKACB	-0.143815639929847
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1938	35/9376	0.967595459236326	PFKP/FBP1/PMM2/HSD17B14/HK3/GMPPA/GMDS	-0.0980342080224153
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/1938	86/9376	0.956344349245206	CREB5/CREB3L2/GNA11/GNAQ/ATF4/CREB3/CAMK2D/ATP1B1/KCNN4/PLCB2/PLCB1/PRKCB/ADCY9/ADCY7/ATF6B/PRKACB/CCK	-0.207594705281247
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1938	10/9376	0.967595459236326	ETHE1/PAPSS2	-0.0523315058513724
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1938	26/9376	0.930380249265698	SLC46A1/LMBRD1/TCN2/BTD/SLC5A6	-0.181446155226729
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/1938	57/9376	0.933644741368385	ACSL3/ACOX1/ACADVL/SCD5/ACAA2/PPT1/TECR/ACADL/ACSL5/MECR/ACADM	-0.256485345135555
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1938	52/9376	0.930380249265698	HSD3B1/HSD17B1/IGF1R/ALOX5/INSR/PTGS2/ADCY9/CYP19A1/ADCY7/PRKACB	-0.256961134444587
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1938	21/9376	0.921519484986977	BCAT1/DPYD/BCAT2/PPCS	-0.183773985239994
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1938	69/9376	0.911502968845814	CTSB/ITPR2/CALM2/GNAQ/PTGER4/ADRB1/GNAI2/KCNJ2/EDN1/PPP3CA/PLCB2/PLCB1/PRKACB	-0.376602178093369
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1938	69/9376	0.911502968845814	CREB5/CALM2/CREB3L2/FOS/ATF4/CREB3/CAMK2D/FOSB/PPP3CA/PRKCB/JUN/ATF6B/PRKACB	-0.376602178093369
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/1938	97/9376	0.897768982796591	CALM2/FOS/GNAQ/GNAI2/MAPK3/CAMK2D/PLCB2/PLCB1/PER2/PRKCB/ADCY9/ADCY7/GNB1/MAPK1/PRKACB/NOS1AP/PRKG1/GNB4	-0.516597618056277
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	26/1938	138/9376	0.911502968845814	ITPR2/CALM2/IGF1R/CPEB2/YWHAZ/CPEB4/MAPK3/ANAPC13/PPP2R5E/FBXW11/PPP2CB/CAMK2D/SLK/YWHAH/PPP2CA/PPP3CA/YWHAG/SKP1/SMC1B/ADCY9/ADCY7/MAPK1/PRKACB/MAD1L1/RBX1/RPS6KA1	-0.534581226755487
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1938	18/9376	0.806329549363605	LMBRD1/PRDX1/TCN2	-0.419800095216349
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1938	83/9376	0.874333246297885	ACSL3/PRDX5/ACOX1/ABCD1/PRDX1/CROT/GSTK1/PEX6/NUDT19/SOD2/DECR2/AGPS/PEX11B/PEX3/ACSL5	-0.586970008625248
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1938	24/9376	0.806329549363605	EXT1/B3GAT3/B4GALT7/NDST1	-0.484898870403403
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/1938	89/9376	0.869748727403439	GLUL/GABARAPL2/GABARAPL1/GABARAP/GLS/GNAI2/SLC38A1/PRKCB/SLC38A2/ADCY9/GABRE/ABAT/ADCY7/GNB1/PRKACB/GNB4	-0.630193171856445
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1938	63/9376	0.844726194571396	PLOD3/KMT2C/PLOD2/PRDM2/PHYKPL/KMT2E/KMT2B/SETD7/SMYD2/EZH1/EHMT1	-0.631187090172106
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1938	36/9376	0.806329549363605	AGL/UGP2/PYGB/GAA/PGM2/HK3	-0.594258788036865
NA	NA	hsa04981	Folate transport and metabolism	5/1938	31/9376	0.780318918738973	FOLR1/SLCO2B1/SLC46A1/ABCC3/FOLR2	-0.625342994677572
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	26/1938	143/9376	0.879632235669387	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ACTN4/HLA-DQA1/FCGR3A/HLA-DMA/HLA-DQB1/HLA-DMB/C1QA/C1QB/HLA-DQA2/FCGR1A/C1QC/CD86/FCGR2A/TNF/ACTN1/C2/CD40/HLA-DOA/C3/IL10/HLA-DRB5/TRIM21	-0.740357077927683
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	23/1938	128/9376	0.869324045407637	PDE7A/NME3/GUK1/RRM2B/ENTPD4/LACC1/PDE10A/PGM2/NUDT9/DGUOK/AMPD3/AK9/GMPR/PDE4A/GDA/ADCY9/AK3/ENTPD1/GMPR2/ADCY7/PDE8A/PAPSS2/ENTPD6	-0.759820826261016
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	18/1938	102/9376	0.85376069932617	ITPR2/ATP2B4/RAP1B/BST1/SLC4A2/RAC1/GNAQ/RAB27B/RAB11A/ATP1B1/PLCB2/PLCB1/RAP1A/PRKCB/ADCY9/ADCY7/SLC9A1/CCK	-0.757992797955006
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1938	43/9376	0.787577699378405	ACSL3/ACOX1/ACADVL/ACAA2/ACADL/ACSL5/ACADM	-0.712620219357684
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1938	38/9376	0.763891152028679	BST1/NMRK1/NAMPT/NADK/SIRT6/SIRT7	-0.744408911001869
NA	NA	hsa04081	Hormone signaling	40/1938	219/9376	0.883648821220389	IGF2/CSH1/CSH2/NPPB/IRS2/IGF1R/ADIPOR1/STAT3/HAMP/SMAD4/SLC40A1/GNA11/PIK3R1/PIK3CA/GNAQ/ADRB1/GNAI2/SLC16A2/THRB/INSR/GNA13/GNA15/STAT5B/PIK3CD/STAT5A/PLCB2/OXTR/PLCB1/PIK3R3/ADCY9/ADCY7/GNB1/PIK3CB/STK11/PRKACB/CSHL1/ITGB3/PRKG1/GNB4/CCK	-0.889304879933725
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/1938	115/9376	0.841387355857675	DUSP1/KRAS/ITPR2/ALOX5/GNAQ/GNAI2/MAPK3/PTGS2/APP/PLCB2/PTGS1/PLCB1/PRKCB/GNB1/ARAF/MAPK1/PRKACB/GNB4/SLC6A4/NRAS	-0.873558956179383
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1938	28/9376	0.691139613740233	ACAA2/PPT1/TECR/MECR	-0.835442013313729
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1938	28/9376	0.691139613740233	PTS/CBR1/SPR/ALPP	-0.835442013313729
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1938	34/9376	0.711467249438475	CRCP/POLR2K/POLR3D/POLR2C/POLR3GL	-0.860298331192599
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1938	22/9376	0.659724176752041	AOC1/HNMT/ALDH3B1	-0.815601824347537
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	46/1938	254/9376	0.876169116631319	EGFR/PDGFA/ITPR2/MET/P2RX4/FLT1/ERBB3/EDNRB/ATP2B4/CALM2/CXCR4/PDGFB/FGFR2/TPCN1/BDKRB2/GNA11/STIM2/PLCD3/FGF1/GNAQ/MCOLN1/NFATC2/ADRB1/PTAFR/SLC8A1/CAMK1/MCU/PHKB/CAMK1D/CAMK2D/GNA15/ITPKC/PPP3CA/VEGFA/PLCB2/ORAI2/OXTR/PLCB1/P2RX7/PRKCB/ADCY9/ADCY7/NFATC3/ORAI3/SPHK1/PRKACB	-1.02125743883663
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1938	16/9376	0.604747162022704	IL4I1/ALDH3B1	-0.807665442979764
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1938	41/9376	0.707996677489995	POLD4/RAD50/UIMC1/NBN/RPA1/RBBP8	-0.956438385735765
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1938	23/9376	0.631040516893256	POMGNT1/B4GALT3/B3GAT2	-0.904277168102364
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1938	23/9376	0.631040516893256	PCYOX1/FNTA/RCE1	-0.904277168102364
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1938	65/9376	0.744304199412559	MGLL/LPL/PNPLA2/DGKH/LPIN2/MBOAT2/DGKA/LPIN1/GK/MBOAT1	-1.05588482424361
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1938	48/9376	0.705538355693154	BCAT1/AUH/IL4I1/ACAA2/BCAT2/ABAT/ACADM	-1.043973609771
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1938	17/9376	0.56917379955078	CYP27A1/HSD3B7	-0.907499263811583
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1938	17/9376	0.56917379955078	CDO1/FMO4	-0.907499263811583
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/1938	54/9376	0.716737377212093	BCAT1/CDO1/SMS/SDS/IL4I1/LACC1/SDSL/BCAT2	-1.06553087940214
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1938	37/9376	0.65378071570022	GLUL/GLS/IL4I1/GFPT1/ABAT	-1.07705124269928
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1938	31/9376	0.624255134991178	ACOX1/DPYD/ALDH3B1/ABAT	-1.0695933294326
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	47/1938	268/9376	0.848451242240808	PINK1/DUSP1/GPR37/UBC/NFE2L2/SLC39A8/UBE2J1/ITPR2/TXN/SLC11A2/CALM2/UBE2L6/TUBA1A/TUBB2A/SLC39A13/MAP3K5/BCL2L1/ATF6/UBE2G1/ATF4/UBA7/GNAI2/PSMD7/BAX/SLC39A11/MFN2/DAXX/MCU/CAMK2D/KIF5B/PSMA5/MT-ND4L/CASP9/PSMA3/EIF2AK3/PSMD8/NDUFA13/TUBA4A/SLC39A7/LRRK2/XBP1/PRKACB/PSMD1/PSMC6/PSMD9/UBB/MAPK8	-1.28482123077521
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1938	91/9376	0.744304199412559	PDE7A/ARRB1/ARRB2/GNAI2/PDE10A/PDE4A/PRKCB/ADCY9/GABRE/ADCY7/PDE8A/GNB1/PRKACB/GNB4	-1.25108775980399
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1938	45/9376	0.645063639490884	ABCA1/ABCG1/TAP1/ABCD1/ABCC3/ABCA5	-1.21822383249093
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1938	63/9376	0.691139613740233	HPGD/PTGES/GPX4/ALOX5/CBR1/TBXAS1/PTGS2/PTGS1/LTA4H	-1.2555156224491
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1938	19/9376	0.509260768019119	OGDH/GLDC	-1.09293341004404
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1938	46/9376	0.631040516893256	FTL/FTH1/HMOX1/ALAD/BLVRA/GUSB	-1.28041634282697
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/1938	82/9376	0.707996677489995	UPP1/NME3/GSTT1/TYMP/UCK2/RRM2B/TK2/CDA/DPYD/GUSB/CES2/GSTM3	-1.35558833394827
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	65/1938	368/9376	0.854534033292951	PINK1/WIPI1/SQSTM1/ANXA11/MAP1LC3B/TNFRSF1A/TUBA1A/RAB5A/TUBB2A/ULK1/MAP3K5/BCL2L1/CASP1/ATF6/RAB1A/OPTN/RAC1/GPX1/MAP2K3/ATF4/TNF/ATXN2/UBQLN1/ANXA7/PSMD7/RB1CC1/BAX/ATXN2L/DCTN1/BECN1/DCTN6/ACTR10/ACTR1A/DAXX/MCU/ACTB/KIF5B/TBK1/WIPI2/TNFRSF1B/PPP3CA/PSMA5/MT-ND4L/CASP9/PSMA3/BAD/EIF2AK3/PSMD8/NDUFA13/TUBA4A/ATG14/FIG4/PIK3C3/ULK2/PFN1/CHMP2B/TANK/SPG11/UBQLN2/XBP1/NXT1/PSMD1/BID/PSMC6/PSMD9	-1.45313363591703
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1938	12/9376	0.403164774681803	NPC1	-1.05596325345374
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1938	27/9376	0.53755303290907	ACOX1/SCD5/TECR	-1.2282751777107
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	34/1938	205/9376	0.802396234488661	TGFBR1/CTSD/MPC1/NCF2/PDK4/CD36/CYBB/MMP9/PIK3R1/PIK3CA/RAC1/GSK3B/NCF4/INSR/RELA/RAC2/CAMK2D/GFPT1/TGFB2/SMAD3/PIK3CD/MT-ND4L/SMAD2/PLCB2/TGFBR2/PLCB1/PIK3R3/PRKCB/NDUFA13/PPARA/PIK3CB/NFKB1/SP1/MAPK8	-1.46015257118699
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	53/1938	308/9376	0.832509080187099	CLTB/WIPI1/SLC1A3/CREB5/CREB3L2/TUBA1A/TUBB2A/ULK1/MAP3K5/CREBBP/GNAQ/GPX1/BBC3/AP2A2/PSMD7/RB1CC1/BAX/CLTC/DCTN1/CREB3/BECN1/DCTN6/ACTR10/ACTR1A/EP300/RCOR1/KIF5B/WIPI2/PSMA5/MT-ND4L/CASP9/POLR2K/PSMA3/PLCB2/POLR2C/AP2B1/PSMD8/PLCB1/MAP2K7/BDNF/NDUFA13/TUBA4A/SOD2/CASP8/ATG14/PIK3C3/ULK2/PSMD1/TBP/PSMC6/SP1/PSMD9/MAPK8	-1.52561625613647
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1938	54/9376	0.627145205060582	ERCC1/HES1/ERCC4/POLI/WDR48/REV3L/RPA1	-1.4025440195072
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1938	13/9376	0.372152099706279	RAD50	-1.15625346758287
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/1938	44/9376	0.549770147293367	POLD4/PARP4/MPG/TDG/XRCC1	-1.52794491844995
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1938	23/9376	0.420693677928837	GLUL/GLS	-1.41981302655595
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1938	23/9376	0.420693677928837	POLD4/RPA1	-1.41981302655595
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1938	23/9376	0.420693677928837	GLS/ATP1B1	-1.41981302655595
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1938	15/9376	0.322531819745442	ALPP	-1.34031798831368
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1938	31/9376	0.468191351243384	GLUL/HYI/GLDC	-1.51384366418764
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1938	31/9376	0.468191351243384	TMEM208/IMMP2L/SEC62	-1.51384366418764
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/1938	59/9376	0.573997306326634	GPX4/SMS/GSTT1/GPX1/RRM2B/GSTK1/GSTM3	-1.67546261143148
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	14/1938	103/9376	0.657589147053814	COL17A1/SLC7A7/MME/DPP4/COL4A5/SLC8A1/COL5A1/ATP1B1/COL4A2/KCNN4/SLC38A2/PRCP/COL8A2/SLC3A2	-1.78357116087911
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1938	33/9376	0.439816117834694	BCAT1/BCAT2/OGDH	-1.64542784343783
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1938	17/9376	0.28458689977539	PAPSS2	-1.50695770382126
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1938	17/9376	0.28458689977539	GLUL	-1.50695770382126
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1938	41/9376	0.47199778499333	SDS/BPGM/SDSL/GLDC	-1.72943780860091
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1938	26/9376	0.372152099706279	HES1/HHEX	-1.63632570317925
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1938	36/9376	0.403164774681803	UGP2/GUSB/FGGY	-1.8313303681065
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/1938	103/9376	0.610618493692827	PPP2R3A/SYMPK/PPP2R2A/PPP2R2B/PPP2R5E/SMG1/PPP2CB/DDX19B/PPP2CA/UPF1/DDX19A/NXT1/PPP2R3C	-2.02823485077527
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1938	29/9376	0.333653606633216	CALM2/GNB1	-1.83441404376288
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1938	20/9376	0.241898864809082	LIPA	-1.73233338783899
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	20/1938	149/9376	0.649392925661964	MGLL/ITPR2/GNAQ/GNAI2/MAPK3/DAGLB/PTGS2/MT-ND4L/PLCB2/PLCB1/PRKCB/NDUFA13/ADCY9/GABRE/ADCY7/GNB1/MAPK1/PRKACB/GNB4/MAPK8	-2.20200340515432
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/1938	47/9376	0.411742748611203	HAGH/ME2/ACYP2/ME3	-2.06363606583272
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1938	31/9376	0.312127567495589	GUSB/HSD17B14	-1.95809399894267
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/1938	32/9376	0.302373581011352	ACOX1/ABAT	-2.01774337815461
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1938	90/9376	0.53755303290907	RXRA/SLC4A2/AQP9/ATP1B1/NCEH1/ABCC3/ADCY9/ADCY7/PRKACB/SLC9A1	-2.25010760816481
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	20/1938	154/9376	0.628308739763848	RFK/BCAT1/PTS/NME3/RDH13/ALAD/UGP2/CTPS1/BCAT2/GUSB/SPR/PPCS/PMM2/NADK/CMPK2/AK9/ALPP/GMPPA/AK3/PDXK	-2.37391185058173
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1938	43/9376	0.337533299733602	ABCA1/CD36/SLC27A1	-2.22239926730654
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	33/1938	235/9376	0.679375535208484	MGLL/ACSL3/KRAS/PRKAB2/CREB5/NPPB/CREB3L2/SOS1/MAP3K5/FRS2/PRKAG2/PNPLA2/SOS2/MAP2K3/COX19/RHEB/CREB3/ACTB/MT-ND4L/TSC2/SIRT6/TSC1/NDUFA13/ADCY9/ADCY7/ARID1B/ARID1A/ACSL5/KDM3A/PRKACB/PRKG1/RPS6KA1/NRAS	-2.54078649124239
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/1938	67/9376	0.433251698165519	PFKP/BPGM/FBP1/PGM2/ALDH3B1/HK3	-2.37635079505359
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/1938	75/9376	0.451544547643619	BCAT1/GLUL/SDS/PFKP/SDSL/BCAT2/TALDO1	-2.43411787344534
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/1938	36/9376	0.268776516454535	POLD4/RPA1	-2.24368756146305
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1938	26/9376	0.18607604985314	ACOX1	-2.12128555249676
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	13/1938	116/9376	0.542187110778976	ACOX1/SDS/PFKP/ME2/FBP1/SDSL/H6PD/OGDH/GLDC/HK3/TALDO1/ME3/IDNK	-2.53247959277462
Human Diseases	Substance dependence	hsa05034	Alcoholism	25/1938	191/9376	0.633243101594454	KRAS/CREB5/CALM2/CREB3L2/SOS1/SLC29A3/SOS2/HDAC7/ATF4/GNAI2/MAPK3/HAT1/CREB3/FOSB/HDAC10/CAMKK2/BDNF/ATF6B/SHC1/GNB1/ARAF/MAPK1/PRKACB/GNB4/NRAS	-2.61390519670003
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1938	37/9376	0.261512286280088	IL4I1/ALDH3B1	-2.29735646120589
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1938	27/9376	0.179184344303023	ABAT	-2.18011483935343
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/1938	87/9376	0.444871475510955	TPM1/CACNG4/CACNA2D3/SLC8A1/ATP1B1/TNNT2/TPM3/SLC9A1	-2.65523598941625
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1938	66/9376	0.366513431528911	HSD17B11/HSD3B1/HSD17B1/STS/CYP19A1	-2.63614306512753
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1938	30/9376	0.161265909872721	OGDH	-2.34858602170606
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/1938	50/9376	0.290278637770898	AOC1/SMS/SAT1	-2.5683819646435
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/1938	42/9376	0.230379871246744	AOC1/IL4I1	-2.55153542430059
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1938	68/9376	0.355733624719238	RDH13/ALDH1A3/ALDH1A1/DHRS4L2/CYP26B1	-2.72161175715912
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1938	70/9376	0.345569806870116	GSTT1/CBR1/GSTK1/PTGS2/GSTM3	-2.80520924436072
NA	NA	hsa04082	Neuroactive ligand signaling	24/1938	199/9376	0.583474648785724	SLC1A3/P2RX4/GNA11/TAC3/GNAQ/P2RY6/ADRB1/GNAI2/SLC1A6/OGFR/PLCB2/ADORA3/ACHE/PLCB1/PRKCB/ADCY9/GABRE/SLC6A2/ADCY7/GNB1/PRKACB/P2RY11/GNB4/SLC6A4	-3.03146144520023
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/1938	108/9376	0.447960860757558	UBE2I/KPNA6/KPNA1/KPNA3/DDX19B/RANGAP1/UPF1/DDX19A/SUMO1/NXT1	-2.94525683666982
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1938	73/9376	0.331368307957646	GSTT1/GSTK1/GSTM3/ALDH3B1/FMO4	-2.92732751410176
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/1938	39/9376	0.124050699902093	GLDC	-2.79796341543926
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1938	79/9376	0.30620109469504	GSTT1/CBR1/GSTK1/GSTM3/ALDH3B1	-3.16089578955828
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1938	41/9376	0.117999446248332	GABRE	-2.88893694289863
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/1938	138/9376	0.420693677928837	ATP6V0E1/ATP6V0D1/ATP6V1D/ATP6V1E1/ATP6V1G1/TCIRG1/ATP6AP1/ATP6V1H/ATP6V1C1/ATP6V0B/MT-ND4L/NDUFA13	-3.49939744058142
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1938	86/9376	0.168766649866801	PLCB2/PLCB1/PRKACB	-3.95274470446178
Genetic Information Processing	Transcription	hsa03040	Spliceosome	19/1938	243/9376	0.378278060195272	HSPA1B/HSPA1A/HSPA6/SNRNP27/PCBP1/CRNKL1/SLU7/CWC25/PRPF6/SART1/PRPF18/DDX5/SF3A1/CDC5L/CCDC12/SNW1/DDX46/SMNDC1/GPKOW	-5.01218438175057
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	10/1938	183/9376	0.264370344053641	REXO2/SBDS/XRN1/CSNK2B/UTP18/EIF6/RPP38/TBL3/NXT1/XRN2	-5.12968363218824
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	30/1938	370/9376	0.392268429420132	CSH1/CSH2/P2RX4/EDNRB/C5AR1/FPR3/NR3C1/BDKRB2/C3AR1/TAC3/P2RY6/PTGER4/ADRB1/PTAFR/THRB/FPR1/CHRNB1/EDN1/OGFR/C3/OXTR/ADORA3/P2RX7/GABRE/LPAR6/S1PR4/CSHL1/GPR35/P2RY11/CCK	-6.08809086998616
Genetic Information Processing	Translation	hsa03010	Ribosome	3/1938	222/9376	0.065378071570022	RPS4Y1/MRPL46/RPS27L	-7.19351969690454
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/1938	449/9376	0.107750051139903	CALM2/ARRB1/ANO2/ARRB2/SLC8A1/CAMK2D/RGS2/GNB1/PRKACB/PRKG1	-9.88988797780552