ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003779 actin binding 184/3699 443/18639 0.415349887133183 2.09291877433777 3.51751921487883e-26 4.69940567107811e-23 GO:0045296 cadherin binding 142/3699 334/18639 0.425149700598802 2.14229934292 1.33548014275878e-21 8.92100735362865e-19 GO:0051020 GTPase binding 129/3699 315/18639 0.40952380952381 2.0635615803499 4.16695277517658e-18 1.85568296921197e-15 GO:0031267 small GTPase binding 118/3699 283/18639 0.416961130742049 2.10103771719412 2.18455807075079e-17 7.29642395630762e-15 GO:0044389 ubiquitin-like protein ligase binding 129/3699 322/18639 0.400621118012422 2.01870154599447 3.50740472321157e-17 7.84507777505155e-15 GO:0051015 actin filament binding 95/3699 209/18639 0.454545454545455 2.29042247290422 3.52323852172974e-17 7.84507777505155e-15 GO:0140297 DNA-binding transcription factor binding 172/3699 488/18639 0.352459016393443 1.77601611423557 6.09783966681657e-16 1.16381625640956e-13 GO:0030695 GTPase regulator activity 172/3699 489/18639 0.351738241308793 1.77238417944163 7.59754820877743e-16 1.26879055086583e-13 GO:0060589 nucleoside-triphosphatase regulator activity 172/3699 490/18639 0.351020408163265 1.76876706887134 9.45555995340114e-16 1.40362534419377e-13 GO:0031625 ubiquitin protein ligase binding 119/3699 302/18639 0.394039735099338 1.98553842187525 2.50946882070555e-15 3.35265034446261e-13 GO:0005096 GTPase activator activity 107/3699 271/18639 0.394833948339483 1.98954040635297 5.4604489883045e-14 6.63196349852256e-12 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 123/3699 349/18639 0.35243553008596 1.77589776838935 8.91814882567614e-12 9.92887235925277e-10 GO:0005543 phospholipid binding 160/3699 497/18639 0.321931589537223 1.62219056431044 3.00976974962225e-11 3.09311721961179e-09 GO:0019902 phosphatase binding 76/3699 190/18639 0.4 2.01557177615572 1.15449971614772e-10 1.04360141052451e-08 GO:0019003 GDP binding 40/3699 75/18639 0.533333333333333 2.68742903487429 1.17170817049908e-10 1.04360141052451e-08 GO:0035091 phosphatidylinositol binding 101/3699 284/18639 0.355633802816901 1.79201363901169 3.60150437666952e-10 3.00725615451905e-08 GO:0003712 transcription coregulator activity 155/3699 495/18639 0.313131313131313 1.57784659244513 5.92276855881044e-10 4.65459929092397e-08 GO:0035591 signaling adaptor activity 55/3699 129/18639 0.426356589147287 2.14838076915823 2.76434886447123e-09 1.97990279033911e-07 GO:0004674 protein serine/threonine kinase activity 137/3699 433/18639 0.316397228637413 1.59430331023865 2.81573001620083e-09 1.97990279033911e-07 GO:0016922 nuclear receptor binding 57/3699 137/18639 0.416058394160584 2.09648889125686 4.28365900603908e-09 2.86148421603411e-07 GO:0106310 protein serine kinase activity 117/3699 361/18639 0.32409972299169 1.63311563580484 8.84932805687718e-09 5.62985823047043e-07 GO:1901981 phosphatidylinositol phosphate binding 70/3699 185/18639 0.378378378378378 1.90662195041757 9.89619933048846e-09 5.84966324329631e-07 GO:0043130 ubiquitin binding 45/3699 100/18639 0.45 2.26751824817518 1.00705280386089e-08 5.84966324329631e-07 GO:0019787 ubiquitin-like protein transferase activity 144/3699 479/18639 0.30062630480167 1.51483473782058 4.40647880420988e-08 2.45293986767683e-06 GO:0005126 cytokine receptor binding 92/3699 275/18639 0.334545454545455 1.68575094005751 6.45375664681037e-08 3.44888755205546e-06 GO:0023023 MHC protein complex binding 22/3699 37/18639 0.594594594594595 2.99612020779904 1.37633824555815e-07 7.07226113871418e-06 GO:0019207 kinase regulator activity 94/3699 287/18639 0.327526132404181 1.65038107106827 1.44044787397193e-07 7.12754948009815e-06 GO:0003925 G protein activity 28/3699 54/18639 0.518518518518518 2.61277822835 1.56896222284992e-07 7.4045885352086e-06 GO:0023026 MHC class II protein complex binding 18/3699 27/18639 0.666666666666667 3.35928629359286 1.60728343952881e-07 7.4045885352086e-06 GO:0046332 SMAD binding 36/3699 79/18639 0.455696202531646 2.29622101081031 1.99089673385686e-07 8.86612678810921e-06 GO:0016755 aminoacyltransferase activity 145/3699 496/18639 0.292338709677419 1.47307413075897 2.57885850772393e-07 1.11140482784489e-05 GO:0019209 kinase activator activity 56/3699 148/18639 0.378378378378378 1.90662195041757 2.85742905964763e-07 1.19297663240288e-05 GO:0005085 guanyl-nucleotide exchange factor activity 78/3699 230/18639 0.339130434782609 1.70885433195811 3.38513673613484e-07 1.37046747862914e-05 GO:0004842 ubiquitin-protein transferase activity 133/3699 449/18639 0.296213808463252 1.49260048011531 3.60065208932893e-07 1.41484446804219e-05 GO:0019887 protein kinase regulator activity 84/3699 255/18639 0.329411764705882 1.65988263918706 4.9611958168639e-07 1.89375931752291e-05 GO:0019903 protein phosphatase binding 54/3699 144/18639 0.375 1.88959854014599 6.44387060703998e-07 2.39139198083484e-05 GO:0035173 histone kinase activity 110/3699 360/18639 0.305555555555556 1.5396728845634 7.05235608967967e-07 2.54647236103028e-05 GO:0032182 ubiquitin-like protein binding 47/3699 120/18639 0.391666666666667 1.97358069748581 7.9482972855967e-07 2.79445399304137e-05 GO:0140996 histone H3 kinase activity 109/3699 357/18639 0.305322128851541 1.53849666387236 8.23905334789841e-07 2.82240391610058e-05 GO:0004679 AMP-activated protein kinase activity 81/3699 248/18639 0.326612903225806 1.64577937367554 1.15779751202749e-06 3.84717560592771e-05 GO:0005178 integrin binding 58/3699 161/18639 0.360248447204969 1.81526650647565 1.18064520840596e-06 3.84717560592771e-05 GO:0140030 modification-dependent protein binding 61/3699 173/18639 0.352601156069364 1.77673234603322 1.45295986081374e-06 4.62179612868372e-05 GO:0140857 histone H3T45 kinase activity 80/3699 246/18639 0.32520325203252 1.63867624077701 1.62724279605611e-06 5.0558055244906e-05 GO:0141003 histone H2AX kinase activity 107/3699 354/18639 0.30225988700565 1.52306624328151 1.74897445106466e-06 5.31052242414178e-05 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 79/3699 243/18639 0.325102880658436 1.63817047650516 1.91007113311359e-06 5.52717880159017e-05 GO:0035402 histone H3T11 kinase activity 80/3699 247/18639 0.323886639676113 1.63204192401273 1.94444164427199e-06 5.52717880159017e-05 GO:0035403 histone H3T6 kinase activity 80/3699 247/18639 0.323886639676113 1.63204192401273 1.94444164427199e-06 5.52717880159017e-05 GO:0003713 transcription coactivator activity 82/3699 256/18639 0.3203125 1.6140320863747 2.38360531571611e-06 5.57335426087128e-05 GO:0004676 3-phosphoinositide-dependent protein kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0004711 ribosomal protein S6 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0035175 histone H3S10 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0035979 histone H2AXS139 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0044022 histone H3S28 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0044023 histone H4S1 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0044024 histone H2AS1 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0044025 histone H2BS14 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0072354 histone H3T3 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0072371 histone H2AS121 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0072518 Rho-dependent protein serine/threonine kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0140823 histone H2BS36 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0140855 histone H3S57 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0140995 histone H2A kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0140997 histone H4 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0140998 histone H2B kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:1990244 histone H2AT120 kinase activity 79/3699 245/18639 0.322448979591837 1.62479765628879 2.72134266505869e-06 5.57335426087128e-05 GO:0030295 protein kinase activator activity 51/3699 139/18639 0.366906474820144 1.84881583784068 2.75330375162803e-06 5.57335426087128e-05 GO:0002020 protease binding 50/3699 136/18639 0.367647058823529 1.85254758837842 3.21021517114443e-06 6.36350723195317e-05 GO:0004677 DNA-dependent protein kinase activity 79/3699 246/18639 0.321138211382114 1.61819278776729 3.23891086656299e-06 6.36350723195317e-05 GO:0050681 nuclear androgen receptor binding 16/3699 26/18639 0.615384615384615 3.10087965562418 3.85119145899346e-06 7.45679969451487e-05 GO:0001786 phosphatidylserine binding 27/3699 59/18639 0.457627118644068 2.30595076085612 5.90478053690888e-06 0.00011269695424729 GO:0003924 GTPase activity 99/3699 331/18639 0.299093655589124 1.50711182658169 6.89723709683508e-06 0.000129784630441854 GO:0001784 phosphotyrosine residue binding 23/3699 47/18639 0.48936170212766 2.46585908785008 7.15868755539567e-06 0.000132833424639009 GO:0003714 transcription corepressor activity 67/3699 204/18639 0.32843137254902 1.65494251228472 7.60864404102108e-06 0.000139248608750742 GO:0017124 SH3 domain binding 43/3699 115/18639 0.373913043478261 1.88412144292817 9.32407509463338e-06 0.00016833735576257 GO:0140375 immune receptor activity 54/3699 156/18639 0.346153846153846 1.7442448062886 1.05088752756544e-05 0.000187198098243657 GO:0046966 nuclear thyroid hormone receptor binding 16/3699 28/18639 0.571428571428571 2.87938825165103 1.46687604591645e-05 0.000257861368071628 GO:0070273 phosphatidylinositol-4-phosphate binding 17/3699 31/18639 0.548387096774194 2.7632838866651 1.66260501450359e-05 0.00028847276615283 GO:0019955 cytokine binding 50/3699 144/18639 0.347222222222222 1.74962827791295 1.99497232198705e-05 0.000336056957344884 GO:0031593 polyubiquitin modification-dependent protein binding 26/3699 59/18639 0.440677966101695 2.22054517712071 2.0123171098496e-05 0.000336056957344884 GO:0045309 protein phosphorylated amino acid binding 26/3699 59/18639 0.440677966101695 2.22054517712071 2.0123171098496e-05 0.000336056957344884 GO:0001221 transcription coregulator binding 42/3699 115/18639 0.365217391304348 1.84030466518566 2.28678210491003e-05 0.000377177887920962 GO:0005160 transforming growth factor beta receptor binding 15/3699 26/18639 0.576923076923077 2.90707467714767 2.33375303655721e-05 0.000380230982541516 GO:0005525 GTP binding 108/3699 378/18639 0.285714285714286 1.43969412582551 2.489896028477e-05 0.000400783264342804 GO:0043236 laminin binding 16/3699 29/18639 0.551724137931034 2.78009900159409 2.6694181312795e-05 0.000424564598022548 GO:0001223 transcription coactivator binding 21/3699 44/18639 0.477272727272727 2.40494359654944 2.88670192083764e-05 0.000453721619557539 GO:0061650 ubiquitin-like protein conjugating enzyme activity 20/3699 41/18639 0.48780487804878 2.45801436116551 2.98856986889064e-05 0.000464270854050919 GO:0019838 growth factor binding 47/3699 136/18639 0.345588235294118 1.74139473307571 3.99363436879912e-05 0.000613275346748923 GO:1902936 phosphatidylinositol bisphosphate binding 40/3699 111/18639 0.36036036036036 1.81583042896912 5.03156660471675e-05 0.000758231758040505 GO:0140313 molecular sequestering activity 24/3699 55/18639 0.436363636363636 2.19880557398806 5.05109479532971e-05 0.000758231758040505 GO:0051219 phosphoprotein binding 35/3699 93/18639 0.376344086021505 1.89637129477016 5.21857984994247e-05 0.000774669186613682 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 33/3699 86/18639 0.383720930232558 1.9335426922424 5.39468045376645e-05 0.000792010229256261 GO:0048306 calcium-dependent protein binding 31/3699 80/18639 0.3875 1.95258515815085 7.22539408448547e-05 0.00104925288009485 GO:0019001 guanyl nucleotide binding 111/3699 400/18639 0.2775 1.39830291970803 7.39425695231571e-05 0.00105092843492487 GO:0032561 guanyl ribonucleotide binding 111/3699 400/18639 0.2775 1.39830291970803 7.39425695231571e-05 0.00105092843492487 GO:0072341 modified amino acid binding 34/3699 91/18639 0.373626373626374 1.88267693377182 7.85845089559388e-05 0.00110514635752773 GO:0032813 tumor necrosis factor receptor superfamily binding 22/3699 50/18639 0.44 2.21712895377129 8.84470237614312e-05 0.00123088774734658 GO:0120283 protein serine/threonine kinase binding 10/3699 15/18639 0.666666666666667 3.35928629359286 0.000104880298029136 0.00144453688831883 GO:0001217 DNA-binding transcription repressor activity 81/3699 278/18639 0.29136690647482 1.46817728299113 0.000120406500977254 0.00164146005413889 GO:0052742 phosphatidylinositol kinase activity 14/3699 26/18639 0.538461538461538 2.71326969867116 0.00012201851867504 0.00164663374696822 GO:0061631 ubiquitin conjugating enzyme activity 17/3699 35/18639 0.485714285714286 2.44748001390337 0.000125850704762538 0.00168136541562751 GO:0098641 cadherin binding involved in cell-cell adhesion 11/3699 18/18639 0.611111111111111 3.07934576912679 0.000146633683860991 0.00193962971919093 GO:0035325 Toll-like receptor binding 9/3699 13/18639 0.692307692307692 3.4884896125772 0.000154897229635454 0.00202884998816634 GO:0098632 cell-cell adhesion mediator activity 23/3699 55/18639 0.418181818181818 2.10718867507189 0.000158497896819446 0.00205585621505611 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 78/3699 268/18639 0.291044776119403 1.46655409085957 0.000165411695596835 0.00212490408959011 GO:0002039 p53 binding 27/3699 69/18639 0.391304347826087 1.9717549984132 0.000170501768858698 0.00216943203043067 GO:0005123 death receptor binding 12/3699 21/18639 0.571428571428571 2.87938825165103 0.000177878665512188 0.00224194242570079 GO:0019208 phosphatase regulator activity 40/3699 117/18639 0.341880341880342 1.72271091979121 0.000188234233096708 0.00235028911604861 GO:0005484 SNAP receptor activity 17/3699 36/18639 0.472222222222222 2.37949445796161 0.000194577134092344 0.00240699121432752 GO:0071889 14-3-3 protein binding 16/3699 33/18639 0.484848484848485 2.44311730443117 0.000203733252365597 0.00247443295600397 GO:0140311 protein sequestering activity 16/3699 33/18639 0.484848484848485 2.44311730443117 0.000203733252365597 0.00247443295600397 GO:0004197 cysteine-type endopeptidase activity 32/3699 88/18639 0.363636363636364 1.83233797832338 0.000225667850408239 0.00271614637968836 GO:0061659 ubiquitin-like protein ligase activity 102/3699 372/18639 0.274193548387097 1.38164194333255 0.000229737430913764 0.00271703323756319 GO:0005159 insulin-like growth factor receptor binding 10/3699 16/18639 0.625 3.14933090024331 0.00022980894898551 0.00271703323756319 GO:0050840 extracellular matrix binding 26/3699 67/18639 0.388059701492537 1.95540545447943 0.000261345706879501 0.00306278828413169 GO:0061791 GTPase motor activity 18/3699 40/18639 0.45 2.26751824817518 0.000270848953096022 0.00311943277014039 GO:1990606 membrane scission GTPase motor activity 18/3699 40/18639 0.45 2.26751824817518 0.000270848953096022 0.00311943277014039 GO:0043394 proteoglycan binding 17/3699 37/18639 0.459459459459459 2.31518379693562 0.000293799877394718 0.00335484304443883 GO:0036408 histone H3K14 acetyltransferase activity 14/3699 28/18639 0.5 2.51946472019465 0.00033908199659993 0.00380683653325636 GO:0051019 mitogen-activated protein kinase binding 14/3699 28/18639 0.5 2.51946472019465 0.00033908199659993 0.00380683653325636 GO:0001540 amyloid-beta binding 30/3699 83/18639 0.36144578313253 1.82129979773107 0.000393859258081272 0.00438496640663816 GO:0098631 cell adhesion mediator activity 28/3699 76/18639 0.368421052631579 1.85644768856448 0.000424366580675082 0.00468556819654471 GO:0140693 molecular condensate scaffold activity 20/3699 48/18639 0.416666666666667 2.09955393349554 0.0004423933423742 0.00484456971649124 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 126/3699 484/18639 0.260330578512397 1.31178741629969 0.000484220768618155 0.00525950363312077 GO:0042605 peptide antigen binding 19/3699 45/18639 0.422222222222222 2.12754798594215 0.000500233803923807 0.00538961582292101 GO:0010484 histone H3 acetyltransferase activity 14/3699 29/18639 0.482758620689655 2.43258662639483 0.000536441998515734 0.00573349208013616 GO:0019888 protein phosphatase regulator activity 36/3699 107/18639 0.336448598130841 1.6953407462992 0.000543216227101671 0.00575981650323677 GO:0070412 R-SMAD binding 13/3699 26/18639 0.5 2.51946472019465 0.00055241079524694 0.00581118757834577 GO:0001618 virus receptor activity 29/3699 81/18639 0.358024691358025 1.80406115767024 0.000585006317862526 0.00610600344269011 GO:0001216 DNA-binding transcription activator activity 127/3699 491/18639 0.258655804480652 1.30334834812513 0.000605959740133959 0.0062756760683641 GO:0061630 ubiquitin protein ligase activity 95/3699 353/18639 0.269121813031161 1.35608582673366 0.000726085618083507 0.00746192604430435 GO:0140272 exogenous protein binding 29/3699 82/18639 0.353658536585366 1.78206041184499 0.000735708379101358 0.00750310224793446 GO:0048156 tau protein binding 18/3699 43/18639 0.418604651162791 2.10931930062808 0.000789723238384888 0.0078568747899192 GO:0003725 double-stranded RNA binding 27/3699 75/18639 0.36 1.81401459854015 0.0008080934315169 0.0078568747899192 GO:0008239 dipeptidyl-peptidase activity 7/3699 10/18639 0.7 3.52725060827251 0.000819697349998776 0.0078568747899192 GO:0032395 MHC class II receptor activity 7/3699 10/18639 0.7 3.52725060827251 0.000819697349998776 0.0078568747899192 GO:0045322 unmethylated CpG binding 7/3699 10/18639 0.7 3.52725060827251 0.000819697349998776 0.0078568747899192 GO:0001968 fibronectin binding 14/3699 30/18639 0.466666666666667 2.351500405515 0.000823325202536443 0.0078568747899192 GO:0043995 histone H4K5 acetyltransferase activity 14/3699 30/18639 0.466666666666667 2.351500405515 0.000823325202536443 0.0078568747899192 GO:0043996 histone H4K8 acetyltransferase activity 14/3699 30/18639 0.466666666666667 2.351500405515 0.000823325202536443 0.0078568747899192 GO:0043997 histone H4K12 acetyltransferase activity 14/3699 30/18639 0.466666666666667 2.351500405515 0.000823325202536443 0.0078568747899192 GO:1990841 promoter-specific chromatin binding 25/3699 68/18639 0.367647058823529 1.85254758837842 0.000874565932376721 0.00828666727415106 GO:0004860 protein kinase inhibitor activity 29/3699 84/18639 0.345238095238095 1.73963040203916 0.00114154708340585 0.0107401894607761 GO:0001727 lipid kinase activity 17/3699 41/18639 0.414634146341463 2.08931220699068 0.00124558756021249 0.0115562845864159 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 17/3699 41/18639 0.414634146341463 2.08931220699068 0.00124558756021249 0.0115562845864159 GO:0004896 cytokine receptor activity 32/3699 96/18639 0.333333333333333 1.67964314679643 0.00128056463566027 0.0117988576085664 GO:0097110 scaffold protein binding 25/3699 70/18639 0.357142857142857 1.79961765728189 0.00141374022630754 0.0121106415663997 GO:0042974 nuclear retinoic acid receptor binding 12/3699 25/18639 0.48 2.41868613138686 0.0014236428961947 0.0121106415663997 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 12/3699 25/18639 0.48 2.41868613138686 0.0014236428961947 0.0121106415663997 GO:0005080 protein kinase C binding 20/3699 52/18639 0.384615384615385 1.93804978476511 0.00147296974942543 0.0121106415663997 GO:0030159 signaling receptor complex adaptor activity 20/3699 52/18639 0.384615384615385 1.93804978476511 0.00147296974942543 0.0121106415663997 GO:0032931 histone H3K56 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0043992 histone H3K9 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0043993 histone H3K18 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0043994 histone H3K23 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0043999 histone H2AK5 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0044012 histone H2AK9 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0044014 histone H2BK5 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0044015 histone H2BK12 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0044016 histone H3K4 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0044017 histone H3K27 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0044018 histone H3K36 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0046972 histone H4K16 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0140908 histone H3K122 acetyltransferase activity 11/3699 22/18639 0.5 2.51946472019465 0.00147757078991254 0.0121106415663997 GO:0010485 histone H4 acetyltransferase activity 15/3699 35/18639 0.428571428571429 2.15954118873827 0.00159786505294038 0.0130167543337094 GO:1990782 protein tyrosine kinase binding 37/3699 117/18639 0.316239316239316 1.59350760080687 0.00167025716813456 0.013524021676532 GO:0042608 T cell receptor binding 7/3699 11/18639 0.636363636363636 3.20659146206591 0.00186731694843213 0.0150285267656947 GO:0004857 enzyme inhibitor activity 107/3699 416/18639 0.257211538461538 1.29607079356167 0.00189760134275481 0.0151808107420385 GO:0043548 phosphatidylinositol 3-kinase binding 12/3699 26/18639 0.461538461538462 2.32565974171814 0.00217041326843563 0.0172599531347024 GO:0140767 enzyme-substrate adaptor activity 42/3699 139/18639 0.302158273381295 1.5225542193982 0.00226951544868777 0.017941258221579 GO:0044013 histone H2B acetyltransferase activity 11/3699 23/18639 0.478260869565217 2.40992277583836 0.00232791765455862 0.0182946940381783 GO:0038024 cargo receptor activity 23/3699 65/18639 0.353846153846154 1.7830058019839 0.00247429322854869 0.0193313201949769 GO:0032452 histone demethylase activity 13/3699 30/18639 0.433333333333333 2.18353609083536 0.00287310574104708 0.0223166818025517 GO:0043998 histone H2A acetyltransferase activity 11/3699 24/18639 0.458333333333333 2.30950932684509 0.00353433022726302 0.0272940184024473 GO:0019210 kinase inhibitor activity 29/3699 90/18639 0.322222222222222 1.62365504190322 0.00370897032145271 0.028043052322783 GO:0035259 nuclear glucocorticoid receptor binding 7/3699 12/18639 0.583333333333333 2.93937550689376 0.00371528462659625 0.028043052322783 GO:0035497 cAMP response element binding 7/3699 12/18639 0.583333333333333 2.93937550689376 0.00371528462659625 0.028043052322783 GO:0070008 serine-type exopeptidase activity 7/3699 12/18639 0.583333333333333 2.93937550689376 0.00371528462659625 0.028043052322783 GO:0000149 SNARE binding 33/3699 106/18639 0.311320754716981 1.56872331634761 0.0038002575715789 0.0283404530786632 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 10/3699 21/18639 0.476190476190476 2.39949020970919 0.00381832451658636 0.0283404530786632 GO:0140312 cargo adaptor activity 10/3699 21/18639 0.476190476190476 2.39949020970919 0.00381832451658636 0.0283404530786632 GO:0004706 JUN kinase kinase kinase activity 9/3699 18/18639 0.5 2.51946472019465 0.00400699590763173 0.0294764205537892 GO:0051371 muscle alpha-actinin binding 8/3699 15/18639 0.533333333333333 2.68742903487429 0.00401550040478266 0.0294764205537892 GO:0140457 protein demethylase activity 13/3699 31/18639 0.419354838709677 2.1130994427439 0.00406027137383684 0.0295062423000623 GO:0042277 peptide binding 67/3699 249/18639 0.269076305220884 1.35585651608869 0.00406373396946966 0.0295062423000623 GO:0004713 protein tyrosine kinase activity 41/3699 140/18639 0.292857142857143 1.47568647897115 0.00470607929485256 0.0339855239887731 GO:0004402 histone acetyltransferase activity 16/3699 42/18639 0.380952380952381 1.91959216776735 0.00474864641968088 0.0341085570789982 GO:0017022 myosin binding 25/3699 76/18639 0.328947368421053 1.65754257907543 0.00501463503866617 0.0358264834848021 GO:0016504 peptidase activator activity 20/3699 57/18639 0.350877192982456 1.76804541768045 0.00512840199097547 0.0364443886167193 GO:0004709 MAP kinase kinase kinase activity 11/3699 25/18639 0.44 2.21712895377129 0.00519272741595955 0.0367062636387405 GO:0030276 clathrin binding 17/3699 46/18639 0.369565217391304 1.86221305405691 0.00525456262352807 0.0369338432861559 GO:0016407 acetyltransferase activity 30/3699 96/18639 0.3125 1.57466545012165 0.00528021262549086 0.0369338432861559 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 6/3699 10/18639 0.6 3.02335766423358 0.00610431838959122 0.0420379864355354 GO:0016303 1-phosphatidylinositol-3-kinase activity 6/3699 10/18639 0.6 3.02335766423358 0.00610431838959122 0.0420379864355354 GO:0070513 death domain binding 6/3699 10/18639 0.6 3.02335766423358 0.00610431838959122 0.0420379864355354 GO:0005149 interleukin-1 receptor binding 8/3699 16/18639 0.5 2.51946472019465 0.0066455220357978 0.0455239278835394 GO:0031994 insulin-like growth factor I binding 7/3699 13/18639 0.538461538461538 2.71326969867116 0.00667866007872285 0.0455239278835394 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 36/3699 122/18639 0.295081967213115 1.48689721191815 0.00678544865781109 0.0460170528265767 GO:0070851 growth factor receptor binding 40/3699 139/18639 0.287769784172662 1.4500516375221 0.00717076242961268 0.0481719465285391 GO:0008013 beta-catenin binding 32/3699 106/18639 0.30188679245283 1.52118624615526 0.00717531239459527 0.0481719465285391 GO:0008238 exopeptidase activity 31/3699 102/18639 0.303921568627451 1.53143933972616 0.00724501482429618 0.0482802098620279 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 15/3699 40/18639 0.375 1.88959854014599 0.00729684813078816 0.0482802098620279 GO:0004725 protein tyrosine phosphatase activity 30/3699 98/18639 0.306122448979592 1.54252942052733 0.00729985208991739 0.0482802098620279 GO:0030296 protein tyrosine kinase activator activity 13/3699 33/18639 0.393939393939394 1.98503280985033 0.00760645345834965 0.0500602060116016 GO:0140789 histone phosphatase activity 39/3699 136/18639 0.286764705882353 1.44498711893517 0.00835502184659927 0.0547172018973364 GO:0140103 catalytic activity, acting on a glycoprotein 10/3699 23/18639 0.434782608695652 2.19083888712578 0.00841590259721652 0.0548470530238111 GO:0032266 phosphatidylinositol-3-phosphate binding 17/3699 48/18639 0.354166666666667 1.78462084347121 0.00853919946198765 0.0551129008754372 GO:0038187 pattern recognition receptor activity 17/3699 48/18639 0.354166666666667 1.78462084347121 0.00853919946198765 0.0551129008754372 GO:0004721 phosphoprotein phosphatase activity 48/3699 175/18639 0.274285714285714 1.38210636079249 0.00928072364912576 0.0596108019001539 GO:0005518 collagen binding 23/3699 72/18639 0.319444444444444 1.60965801567991 0.0101960567758723 0.0651767074285424 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 8/3699 17/18639 0.470588235294118 2.37126091312437 0.0103944330473253 0.0655045403359745 GO:0008429 phosphatidylethanolamine binding 8/3699 17/18639 0.470588235294118 2.37126091312437 0.0103944330473253 0.0655045403359745 GO:0008484 sulfuric ester hydrolase activity 8/3699 17/18639 0.470588235294118 2.37126091312437 0.0103944330473253 0.0655045403359745 GO:0060590 ATPase regulator activity 17/3699 49/18639 0.346938775510204 1.74820000993098 0.0107072404945943 0.0670319734482516 GO:0044548 S100 protein binding 7/3699 14/18639 0.5 2.51946472019465 0.0110911989033057 0.0670319734482516 GO:0005516 calmodulin binding 55/3699 207/18639 0.265700483091787 1.33884598657687 0.0111563980173803 0.0670319734482516 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 6/3699 11/18639 0.545454545454545 2.74850696748507 0.0111887201189821 0.0670319734482516 GO:0002162 dystroglycan binding 6/3699 11/18639 0.545454545454545 2.74850696748507 0.0111887201189821 0.0670319734482516 GO:0005114 type II transforming growth factor beta receptor binding 6/3699 11/18639 0.545454545454545 2.74850696748507 0.0111887201189821 0.0670319734482516 GO:0008432 JUN kinase binding 6/3699 11/18639 0.545454545454545 2.74850696748507 0.0111887201189821 0.0670319734482516 GO:0019215 intermediate filament binding 6/3699 11/18639 0.545454545454545 2.74850696748507 0.0111887201189821 0.0670319734482516 GO:0032050 clathrin heavy chain binding 6/3699 11/18639 0.545454545454545 2.74850696748507 0.0111887201189821 0.0670319734482516 GO:0034713 type I transforming growth factor beta receptor binding 6/3699 11/18639 0.545454545454545 2.74850696748507 0.0111887201189821 0.0670319734482516 GO:0050786 RAGE receptor binding 6/3699 11/18639 0.545454545454545 2.74850696748507 0.0111887201189821 0.0670319734482516 GO:0019905 syntaxin binding 20/3699 61/18639 0.327868852459016 1.65210801324239 0.0117861685382595 0.0702960766389047 GO:0050431 transforming growth factor beta binding 10/3699 24/18639 0.416666666666667 2.09955393349554 0.0119027400043262 0.0703451734907608 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 27/3699 89/18639 0.303370786516854 1.52866398753383 0.0119523610646727 0.0703451734907608 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 27/3699 89/18639 0.303370786516854 1.52866398753383 0.0119523610646727 0.0703451734907608 GO:0005154 epidermal growth factor receptor binding 13/3699 35/18639 0.371428571428571 1.87160236357317 0.0132299366776566 0.077522786848023 GO:0051010 microtubule plus-end binding 9/3699 21/18639 0.428571428571429 2.15954118873827 0.0136602741288748 0.079694874393785 GO:0140793 histone H2AXY142 phosphatase activity 27/3699 90/18639 0.3 1.51167883211679 0.0139223957735217 0.0803729758236449 GO:0097718 disordered domain specific binding 11/3699 28/18639 0.392857142857143 1.97957942301008 0.0139749545990701 0.0803729758236449 GO:0141052 histone H3 demethylase activity 11/3699 28/18639 0.392857142857143 1.97957942301008 0.0139749545990701 0.0803729758236449 GO:0003774 cytoskeletal motor activity 42/3699 153/18639 0.274509803921569 1.38323553265588 0.0140171432387045 0.0803729758236449 GO:0031490 chromatin DNA binding 36/3699 128/18639 0.28125 1.41719890510949 0.0149366830357117 0.0852795236568839 GO:0030228 lipoprotein particle receptor activity 8/3699 18/18639 0.444444444444444 2.23952419572858 0.0155043827590801 0.0874002336123672 GO:0034185 apolipoprotein binding 8/3699 18/18639 0.444444444444444 2.23952419572858 0.0155043827590801 0.0874002336123672 GO:0070064 proline-rich region binding 8/3699 18/18639 0.444444444444444 2.23952419572858 0.0155043827590801 0.0874002336123672 GO:0061733 protein-lysine-acetyltransferase activity 16/3699 47/18639 0.340425531914894 1.71538023502614 0.015835072543206 0.0888893147803496 GO:0005041 low-density lipoprotein particle receptor activity 7/3699 15/18639 0.466666666666667 2.351500405515 0.0172824350895134 0.0962055553316243 GO:0050700 CARD domain binding 7/3699 15/18639 0.466666666666667 2.351500405515 0.0172824350895134 0.0962055553316243 GO:0004177 aminopeptidase activity 14/3699 40/18639 0.35 1.76362530413625 0.0180874714767615 0.0998548012105512 GO:0032451 demethylase activity 14/3699 40/18639 0.35 1.76362530413625 0.0180874714767615 0.0998548012105512 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 11/3699 29/18639 0.379310344827586 1.91131806359594 0.0185624047002511 0.100941861930314 GO:0005078 MAP-kinase scaffold activity 6/3699 12/18639 0.5 2.51946472019465 0.018662155611368 0.100941861930314 GO:0005165 neurotrophin receptor binding 6/3699 12/18639 0.5 2.51946472019465 0.018662155611368 0.100941861930314 GO:0017166 vinculin binding 6/3699 12/18639 0.5 2.51946472019465 0.018662155611368 0.100941861930314 GO:0070410 co-SMAD binding 6/3699 12/18639 0.5 2.51946472019465 0.018662155611368 0.100941861930314 GO:0033691 sialic acid binding 9/3699 22/18639 0.409090909090909 2.0613802256138 0.0191234967104549 0.103020127440193 GO:0140034 methylation-dependent protein binding 23/3699 76/18639 0.302631578947368 1.52493917274939 0.0198752850018167 0.106640083383241 GO:0008234 cysteine-type peptidase activity 49/3699 187/18639 0.262032085561497 1.32036119026244 0.0203967131258195 0.109000034944379 GO:0042805 actinin binding 13/3699 37/18639 0.351351351351351 1.77043466824489 0.021595257110047 0.114945272904473 GO:0005520 insulin-like growth factor binding 8/3699 19/18639 0.421052631578947 2.12165450121655 0.0222086798895779 0.116580265961793 GO:0030971 receptor tyrosine kinase binding 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:0033192 calmodulin-dependent protein phosphatase activity 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:0140791 histone H2AXS140 phosphatase activity 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:1990439 MAP kinase serine/threonine phosphatase activity 24/3699 81/18639 0.296296296296296 1.49301613048572 0.0227750369880449 0.116580265961793 GO:0004715 non-membrane spanning protein tyrosine kinase activity 15/3699 45/18639 0.333333333333333 1.67964314679643 0.0232722390783983 0.118670654231833 GO:0001222 transcription corepressor binding 16/3699 49/18639 0.326530612244898 1.64536471522916 0.0237379271876798 0.120585059782282 GO:0034212 protein N-acetyltransferase activity 17/3699 53/18639 0.320754716981132 1.61626038653996 0.0240115238933939 0.120910208895776 GO:0051018 protein kinase A binding 17/3699 53/18639 0.320754716981132 1.61626038653996 0.0240115238933939 0.120910208895776 GO:0035401 histone H3Y41 kinase activity 32/3699 115/18639 0.278260869565217 1.4021368877605 0.0241639414484822 0.120910208895776 GO:0140801 histone H2AXY142 kinase activity 32/3699 115/18639 0.278260869565217 1.4021368877605 0.0241639414484822 0.120910208895776 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 7/3699 16/18639 0.4375 2.20453163017032 0.0255555896868477 0.126452843783809 GO:0015923 mannosidase activity 7/3699 16/18639 0.4375 2.20453163017032 0.0255555896868477 0.126452843783809 GO:0055102 lipase inhibitor activity 7/3699 16/18639 0.4375 2.20453163017032 0.0255555896868477 0.126452843783809 GO:0005158 insulin receptor binding 9/3699 23/18639 0.391304347826087 1.9717549984132 0.0260069500689654 0.126807610555247 GO:0042171 lysophosphatidic acid acyltransferase activity 9/3699 23/18639 0.391304347826087 1.9717549984132 0.0260069500689654 0.126807610555247 GO:0071617 lysophospholipid acyltransferase activity 9/3699 23/18639 0.391304347826087 1.9717549984132 0.0260069500689654 0.126807610555247 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 9/3699 23/18639 0.391304347826087 1.9717549984132 0.0260069500689654 0.126807610555247 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 24/3699 82/18639 0.292682926829268 1.47480861669931 0.0263081535459351 0.127346714265831 GO:0033549 MAP kinase phosphatase activity 24/3699 82/18639 0.292682926829268 1.47480861669931 0.0263081535459351 0.127346714265831 GO:0048487 beta-tubulin binding 14/3699 42/18639 0.333333333333333 1.67964314679643 0.0278419802260625 0.134284785494655 GO:0140463 chromatin-protein adaptor activity 17/3699 54/18639 0.314814814814815 1.58632963864107 0.0287447811239264 0.137076078757445 GO:0017154 semaphorin receptor activity 6/3699 13/18639 0.461538461538462 2.32565974171814 0.0289337232107781 0.137076078757445 GO:0043560 insulin receptor substrate binding 6/3699 13/18639 0.461538461538462 2.32565974171814 0.0289337232107781 0.137076078757445 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 6/3699 13/18639 0.461538461538462 2.32565974171814 0.0289337232107781 0.137076078757445 GO:0089720 caspase binding 6/3699 13/18639 0.461538461538462 2.32565974171814 0.0289337232107781 0.137076078757445 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 24/3699 83/18639 0.289156626506024 1.45703983818486 0.0302461320239645 0.142284621070481 GO:0030165 PDZ domain binding 24/3699 83/18639 0.289156626506024 1.45703983818486 0.0302461320239645 0.142284621070481 GO:0016004 phospholipase activator activity 8/3699 20/18639 0.4 2.01557177615572 0.0307196026668911 0.144004874256023 GO:0005164 tumor necrosis factor receptor binding 11/3699 31/18639 0.354838709677419 1.7880072207833 0.0309291835002538 0.144480381665521 GO:0005131 growth hormone receptor binding 5/3699 10/18639 0.5 2.51946472019465 0.0317451737812597 0.145744165538704 GO:0005381 iron ion transmembrane transporter activity 5/3699 10/18639 0.5 2.51946472019465 0.0317451737812597 0.145744165538704 GO:0008140 cAMP response element binding protein binding 5/3699 10/18639 0.5 2.51946472019465 0.0317451737812597 0.145744165538704 GO:0015924 mannosyl-oligosaccharide mannosidase activity 5/3699 10/18639 0.5 2.51946472019465 0.0317451737812597 0.145744165538704 GO:1905394 retromer complex binding 5/3699 10/18639 0.5 2.51946472019465 0.0317451737812597 0.145744165538704 GO:0008375 acetylglucosaminyltransferase activity 14/3699 43/18639 0.325581395348837 1.64058167826628 0.0339596248576054 0.15401745846138 GO:0043495 protein-membrane adaptor activity 15/3699 47/18639 0.319148936170213 1.60816897033701 0.0342450715016767 0.15401745846138 GO:0004622 lysophospholipase activity 9/3699 24/18639 0.375 1.88959854014599 0.0344694761077489 0.15401745846138 GO:0035035 histone acetyltransferase binding 9/3699 24/18639 0.375 1.88959854014599 0.0344694761077489 0.15401745846138 GO:0042625 ATPase-coupled ion transmembrane transporter activity 9/3699 24/18639 0.375 1.88959854014599 0.0344694761077489 0.15401745846138 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 9/3699 24/18639 0.375 1.88959854014599 0.0344694761077489 0.15401745846138 GO:0046961 proton-transporting ATPase activity, rotational mechanism 9/3699 24/18639 0.375 1.88959854014599 0.0344694761077489 0.15401745846138 GO:0050699 WW domain binding 9/3699 24/18639 0.375 1.88959854014599 0.0344694761077489 0.15401745846138 GO:0017018 myosin phosphatase activity 24/3699 84/18639 0.285714285714286 1.43969412582551 0.034614788875045 0.154151193123534 GO:0042826 histone deacetylase binding 34/3699 127/18639 0.267716535433071 1.34900473207272 0.0354048123099481 0.157145612113258 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 7/3699 17/18639 0.411764705882353 2.07485329898383 0.0361683993345135 0.158429447576754 GO:0019198 transmembrane receptor protein phosphatase activity 7/3699 17/18639 0.411764705882353 2.07485329898383 0.0361683993345135 0.158429447576754 GO:0031489 myosin V binding 7/3699 17/18639 0.411764705882353 2.07485329898383 0.0361683993345135 0.158429447576754 GO:0046965 nuclear retinoid X receptor binding 7/3699 17/18639 0.411764705882353 2.07485329898383 0.0361683993345135 0.158429447576754 GO:0019789 SUMO transferase activity 10/3699 28/18639 0.357142857142857 1.79961765728189 0.0371186341417861 0.162060441873942 GO:0032934 sterol binding 20/3699 68/18639 0.294117647058824 1.48203807070273 0.0381775585211119 0.166140775844318 GO:0042578 phosphoric ester hydrolase activity 86/3699 363/18639 0.236914600550964 1.19379595557432 0.0389165884342253 0.167739222091621 GO:0008378 galactosyltransferase activity 11/3699 32/18639 0.34375 1.73213199513382 0.0389215260841335 0.167739222091621 GO:0043425 bHLH transcription factor binding 11/3699 32/18639 0.34375 1.73213199513382 0.0389215260841335 0.167739222091621 GO:0061134 peptidase regulator activity 56/3699 226/18639 0.247787610619469 1.24858428611416 0.0396156705306071 0.170181787231161 GO:0044390 ubiquitin-like protein conjugating enzyme binding 12/3699 36/18639 0.333333333333333 1.67964314679643 0.0400742589996622 0.171600032126758 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 8/3699 21/18639 0.380952380952381 1.91959216776735 0.0412176509979779 0.174815180105709 GO:0009931 calcium-dependent protein serine/threonine kinase activity 8/3699 21/18639 0.380952380952381 1.91959216776735 0.0412176509979779 0.174815180105709 GO:0010314 phosphatidylinositol-5-phosphate binding 8/3699 21/18639 0.380952380952381 1.91959216776735 0.0412176509979779 0.174815180105709 GO:0004065 arylsulfatase activity 6/3699 14/18639 0.428571428571429 2.15954118873827 0.0423156164413825 0.177778816244299 GO:0032036 myosin heavy chain binding 6/3699 14/18639 0.428571428571429 2.15954118873827 0.0423156164413825 0.177778816244299 GO:0042043 neurexin family protein binding 6/3699 14/18639 0.428571428571429 2.15954118873827 0.0423156164413825 0.177778816244299 GO:0004722 protein serine/threonine phosphatase activity 28/3699 103/18639 0.271844660194175 1.36980606146505 0.0439528116124383 0.183926021690814 GO:0008080 N-acetyltransferase activity 20/3699 69/18639 0.289855072463768 1.46055925808385 0.0440541369319315 0.183926021690814 GO:0003785 actin monomer binding 10/3699 29/18639 0.344827586206897 1.73756187599631 0.0468850706899626 0.195135372092804 GO:0140296 general transcription initiation factor binding 16/3699 53/18639 0.30188679245283 1.52118624615526 0.0478975730073433 0.197865323405258 GO:0016798 hydrolase activity, acting on glycosyl bonds 34/3699 130/18639 0.261538461538462 1.31787385364028 0.0480311675918945 0.197865323405258 GO:0019956 chemokine binding 11/3699 33/18639 0.333333333333333 1.67964314679643 0.0482425740970633 0.197865323405258 GO:0019864 IgG binding 5/3699 11/18639 0.454545454545455 2.29042247290422 0.0488755518331576 0.197865323405258 GO:0050998 nitric-oxide synthase binding 5/3699 11/18639 0.454545454545455 2.29042247290422 0.0488755518331576 0.197865323405258 GO:0097493 structural molecule activity conferring elasticity 5/3699 11/18639 0.454545454545455 2.29042247290422 0.0488755518331576 0.197865323405258 GO:0140031 phosphorylation-dependent protein binding 5/3699 11/18639 0.454545454545455 2.29042247290422 0.0488755518331576 0.197865323405258 GO:0035064 methylated histone binding 21/3699 74/18639 0.283783783783784 1.42996646281318 0.0491040787830413 0.197865323405258 GO:0042169 SH2 domain binding 13/3699 41/18639 0.317073170731707 1.59770933475758 0.0491537989427726 0.197865323405258 GO:0032393 MHC class I receptor activity 7/3699 18/18639 0.388888888888889 1.9595836712625 0.0493182280643346 0.197865323405258 GO:0035615 clathrin adaptor activity 7/3699 18/18639 0.388888888888889 1.9595836712625 0.0493182280643346 0.197865323405258 GO:1990381 ubiquitin-specific protease binding 7/3699 18/18639 0.388888888888889 1.9595836712625 0.0493182280643346 0.197865323405258 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 56/3699 229/18639 0.244541484716157 1.23222728673275 0.0494766105499148 0.197906442199659 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 8/3699 22/18639 0.363636363636364 1.83233797832338 0.0538428820194195 0.214089554696263 GO:0061133 endopeptidase activator activity 8/3699 22/18639 0.363636363636364 1.83233797832338 0.0538428820194195 0.214089554696263 GO:0008157 protein phosphatase 1 binding 9/3699 26/18639 0.346153846153846 1.7442448062886 0.0566469537559362 0.223245811852303 GO:0034237 protein kinase A regulatory subunit binding 9/3699 26/18639 0.346153846153846 1.7442448062886 0.0566469537559362 0.223245811852303 GO:0050750 low-density lipoprotein particle receptor binding 9/3699 26/18639 0.346153846153846 1.7442448062886 0.0566469537559362 0.223245811852303 GO:0030291 protein serine/threonine kinase inhibitor activity 14/3699 46/18639 0.304347826086957 1.53358722098805 0.0580150646717634 0.224178172119951 GO:0031624 ubiquitin conjugating enzyme binding 10/3699 30/18639 0.333333333333333 1.67964314679643 0.0582392485307064 0.224178172119951 GO:0051721 protein phosphatase 2A binding 10/3699 30/18639 0.333333333333333 1.67964314679643 0.0582392485307064 0.224178172119951 GO:0051117 ATPase binding 23/3699 84/18639 0.273809523809524 1.37970687058278 0.0589662381129134 0.224178172119951 GO:0000774 adenyl-nucleotide exchange factor activity 6/3699 15/18639 0.4 2.01557177615572 0.0590044040092953 0.224178172119951 GO:0004559 alpha-mannosidase activity 6/3699 15/18639 0.4 2.01557177615572 0.0590044040092953 0.224178172119951 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 6/3699 15/18639 0.4 2.01557177615572 0.0590044040092953 0.224178172119951 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 6/3699 15/18639 0.4 2.01557177615572 0.0590044040092953 0.224178172119951 GO:0005523 tropomyosin binding 6/3699 15/18639 0.4 2.01557177615572 0.0590044040092953 0.224178172119951 GO:0042809 nuclear vitamin D receptor binding 6/3699 15/18639 0.4 2.01557177615572 0.0590044040092953 0.224178172119951 GO:0061578 K63-linked deubiquitinase activity 6/3699 15/18639 0.4 2.01557177615572 0.0590044040092953 0.224178172119951 GO:0000146 microfilament motor activity 12/3699 38/18639 0.315789473684211 1.59124087591241 0.0590649076244183 0.224178172119951 GO:0005109 frizzled binding 12/3699 38/18639 0.315789473684211 1.59124087591241 0.0590649076244183 0.224178172119951 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 33/3699 128/18639 0.2578125 1.29909899635036 0.0605254645319165 0.22907087992816 GO:0008381 mechanosensitive monoatomic ion channel activity 7/3699 19/18639 0.368421052631579 1.85644768856448 0.0651321311662761 0.243743773776316 GO:0043395 heparan sulfate proteoglycan binding 7/3699 19/18639 0.368421052631579 1.85644768856448 0.0651321311662761 0.243743773776316 GO:0140036 ubiquitin-modified protein reader activity 7/3699 19/18639 0.368421052631579 1.85644768856448 0.0651321311662761 0.243743773776316 GO:1990380 K48-linked deubiquitinase activity 7/3699 19/18639 0.368421052631579 1.85644768856448 0.0651321311662761 0.243743773776316 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 8/3699 23/18639 0.347826086956522 1.75267110970062 0.0686887123929951 0.254034146660616 GO:0043274 phospholipase binding 8/3699 23/18639 0.347826086956522 1.75267110970062 0.0686887123929951 0.254034146660616 GO:0030246 carbohydrate binding 66/3699 280/18639 0.235714285714286 1.18774765380605 0.0690216131132555 0.254034146660616 GO:0004859 phospholipase inhibitor activity 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:0035197 siRNA binding 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:0097371 MDM2/MDM4 family protein binding 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:0097677 STAT family protein binding 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:1990459 transferrin receptor binding 5/3699 12/18639 0.416666666666667 2.09955393349554 0.070456549134436 0.254034146660616 GO:0001671 ATPase activator activity 9/3699 27/18639 0.333333333333333 1.67964314679643 0.0705439134813536 0.254034146660616 GO:0005044 scavenger receptor activity 9/3699 27/18639 0.333333333333333 1.67964314679643 0.0705439134813536 0.254034146660616 GO:0016411 acylglycerol O-acyltransferase activity 10/3699 31/18639 0.32258064516129 1.625461109803 0.0712440414023504 0.25517973006311 GO:0070325 lipoprotein particle receptor binding 10/3699 31/18639 0.32258064516129 1.625461109803 0.0712440414023504 0.25517973006311 GO:0043539 protein serine/threonine kinase activator activity 20/3699 73/18639 0.273972602739726 1.38052861380529 0.0740866992821747 0.264651952516004 GO:0005521 lamin binding 6/3699 16/18639 0.375 1.88959854014599 0.0790736926027638 0.278006456098138 GO:0022858 alanine transmembrane transporter activity 6/3699 16/18639 0.375 1.88959854014599 0.0790736926027638 0.278006456098138 GO:0030275 LRR domain binding 6/3699 16/18639 0.375 1.88959854014599 0.0790736926027638 0.278006456098138 GO:0031435 mitogen-activated protein kinase kinase kinase binding 6/3699 16/18639 0.375 1.88959854014599 0.0790736926027638 0.278006456098138 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 6/3699 16/18639 0.375 1.88959854014599 0.0790736926027638 0.278006456098138 GO:0070411 I-SMAD binding 6/3699 16/18639 0.375 1.88959854014599 0.0790736926027638 0.278006456098138 GO:0008081 phosphoric diester hydrolase activity 23/3699 87/18639 0.264367816091954 1.33213077159717 0.0824919220050946 0.288817495651388 GO:0015026 coreceptor activity 17/3699 61/18639 0.278688524590164 1.40429181125603 0.0826362434307224 0.288817495651388 GO:0030331 nuclear estrogen receptor binding 12/3699 40/18639 0.3 1.51167883211679 0.0832395693715952 0.288817495651388 GO:0001614 purinergic nucleotide receptor activity 7/3699 20/18639 0.35 1.76362530413625 0.0836619542044065 0.288817495651388 GO:0016502 nucleotide receptor activity 7/3699 20/18639 0.35 1.76362530413625 0.0836619542044065 0.288817495651388 GO:0030742 GTP-dependent protein binding 7/3699 20/18639 0.35 1.76362530413625 0.0836619542044065 0.288817495651388 GO:0042288 MHC class I protein binding 7/3699 20/18639 0.35 1.76362530413625 0.0836619542044065 0.288817495651388 GO:0016409 palmitoyltransferase activity 11/3699 36/18639 0.305555555555556 1.5396728845634 0.0848158909500972 0.291413112518559 GO:0060229 lipase activator activity 8/3699 24/18639 0.333333333333333 1.67964314679643 0.0857983305356183 0.291413112518559 GO:0051059 NF-kappaB binding 10/3699 32/18639 0.3125 1.57466545012165 0.0859360938197219 0.291413112518559 GO:0071813 lipoprotein particle binding 10/3699 32/18639 0.3125 1.57466545012165 0.0859360938197219 0.291413112518559 GO:0071814 protein-lipid complex binding 10/3699 32/18639 0.3125 1.57466545012165 0.0859360938197219 0.291413112518559 GO:0120015 sterol transfer activity 10/3699 32/18639 0.3125 1.57466545012165 0.0859360938197219 0.291413112518559 GO:0046875 ephrin receptor binding 9/3699 28/18639 0.321428571428571 1.6196558915537 0.0863769405369381 0.291413112518559 GO:0051393 alpha-actinin binding 9/3699 28/18639 0.321428571428571 1.6196558915537 0.0863769405369381 0.291413112518559 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 9/3699 28/18639 0.321428571428571 1.6196558915537 0.0863769405369381 0.291413112518559 GO:0005544 calcium-dependent phospholipid binding 15/3699 53/18639 0.283018867924528 1.42611210577056 0.0885826167178626 0.298101702607215 GO:0008017 microtubule binding 64/3699 276/18639 0.231884057971014 1.16844740646708 0.093952651011401 0.315378748118673 GO:0046915 transition metal ion transmembrane transporter activity 13/3699 45/18639 0.288888888888889 1.45569072722357 0.0945067061480897 0.315652398534619 GO:0141110 transporter inhibitor activity 13/3699 45/18639 0.288888888888889 1.45569072722357 0.0945067061480897 0.315652398534619 GO:0004535 poly(A)-specific ribonuclease activity 5/3699 13/18639 0.384615384615385 1.93804978476511 0.0964083153367221 0.318028417999656 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 5/3699 13/18639 0.384615384615385 1.93804978476511 0.0964083153367221 0.318028417999656 GO:0005035 death receptor activity 5/3699 13/18639 0.384615384615385 1.93804978476511 0.0964083153367221 0.318028417999656 GO:0032396 inhibitory MHC class I receptor activity 5/3699 13/18639 0.384615384615385 1.93804978476511 0.0964083153367221 0.318028417999656 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 5/3699 13/18639 0.384615384615385 1.93804978476511 0.0964083153367221 0.318028417999656 GO:0051213 dioxygenase activity 24/3699 93/18639 0.258064516129032 1.3003688878424 0.096954220269636 0.319041473596635 GO:0015175 neutral L-amino acid transmembrane transporter activity 12/3699 41/18639 0.292682926829268 1.47480861669931 0.0973440261007633 0.31953714710226 GO:0061135 endopeptidase regulator activity 44/3699 184/18639 0.239130434782609 1.20496138791918 0.0991253152517034 0.324586816608519 GO:0015485 cholesterol binding 15/3699 54/18639 0.277777777777778 1.39970262233036 0.10112904375091 0.32831825099815 GO:0051087 protein-folding chaperone binding 33/3699 134/18639 0.246268656716418 1.24093038457348 0.101638824804083 0.32831825099815 GO:0140416 transcription regulator inhibitor activity 10/3699 33/18639 0.303030303030303 1.52694831526948 0.10232458065566 0.32831825099815 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 6/3699 17/18639 0.352941176470588 1.77844568484328 0.102476579839991 0.32831825099815 GO:0005092 GDP-dissociation inhibitor activity 6/3699 17/18639 0.352941176470588 1.77844568484328 0.102476579839991 0.32831825099815 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 6/3699 17/18639 0.352941176470588 1.77844568484328 0.102476579839991 0.32831825099815 GO:0036041 long-chain fatty acid binding 6/3699 17/18639 0.352941176470588 1.77844568484328 0.102476579839991 0.32831825099815 GO:0051787 misfolded protein binding 6/3699 17/18639 0.352941176470588 1.77844568484328 0.102476579839991 0.32831825099815 GO:1990226 histone methyltransferase binding 6/3699 17/18639 0.352941176470588 1.77844568484328 0.102476579839991 0.32831825099815 GO:0004629 phospholipase C activity 9/3699 29/18639 0.310344827586207 1.56380568839668 0.104148281968077 0.331290725498455 GO:0035250 UDP-galactosyltransferase activity 9/3699 29/18639 0.310344827586207 1.56380568839668 0.104148281968077 0.331290725498455 GO:0051861 glycolipid binding 9/3699 29/18639 0.310344827586207 1.56380568839668 0.104148281968077 0.331290725498455 GO:0017025 TBP-class protein binding 8/3699 25/18639 0.32 1.61245742092457 0.105163657636951 0.331364732554166 GO:0019706 protein-cysteine S-palmitoyltransferase activity 8/3699 25/18639 0.32 1.61245742092457 0.105163657636951 0.331364732554166 GO:0019707 protein-cysteine S-acyltransferase activity 8/3699 25/18639 0.32 1.61245742092457 0.105163657636951 0.331364732554166 GO:0120020 cholesterol transfer activity 8/3699 25/18639 0.32 1.61245742092457 0.105163657636951 0.331364732554166 GO:0001664 G protein-coupled receptor binding 68/3699 297/18639 0.228956228956229 1.15369428264805 0.106025718879021 0.3332949656997 GO:0005200 structural constituent of cytoskeleton 28/3699 112/18639 0.25 1.25973236009732 0.107130737771563 0.335978088410347 GO:0070063 RNA polymerase binding 16/3699 59/18639 0.271186440677966 1.36648933976659 0.110081005233329 0.344422067896317 GO:0008374 O-acyltransferase activity 15/3699 55/18639 0.272727272727273 1.37425348374253 0.11470925991697 0.357005263980524 GO:0008194 UDP-glycosyltransferase activity 35/3699 145/18639 0.241379310344828 1.21629331319742 0.117200601795957 0.357005263980524 GO:0004090 carbonyl reductase (NADPH) activity 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0004382 GDP phosphatase activity 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0004445 inositol-polyphosphate 5-phosphatase activity 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0005031 tumor necrosis factor receptor activity 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0005522 profilin binding 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0030957 Tat protein binding 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0031996 thioesterase binding 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0042975 peroxisome proliferator activated receptor binding 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0051864 histone H3K36 demethylase activity 4/3699 10/18639 0.4 2.01557177615572 0.118111022963616 0.357005263980524 GO:0044325 transmembrane transporter binding 33/3699 136/18639 0.242647058823529 1.22268140832976 0.118655204411162 0.357840526170007 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 16/3699 60/18639 0.266666666666667 1.34371451743714 0.123758112326235 0.371749001278472 GO:0035925 mRNA 3'-UTR AU-rich region binding 9/3699 30/18639 0.3 1.51167883211679 0.123823582012665 0.371749001278472 GO:0005161 platelet-derived growth factor receptor binding 5/3699 14/18639 0.357142857142857 1.79961765728189 0.126459814723022 0.372394146117424 GO:0008494 translation activator activity 5/3699 14/18639 0.357142857142857 1.79961765728189 0.126459814723022 0.372394146117424 GO:0032454 histone H3K9 demethylase activity 5/3699 14/18639 0.357142857142857 1.79961765728189 0.126459814723022 0.372394146117424 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 5/3699 14/18639 0.357142857142857 1.79961765728189 0.126459814723022 0.372394146117424 GO:0046030 inositol trisphosphate phosphatase activity 5/3699 14/18639 0.357142857142857 1.79961765728189 0.126459814723022 0.372394146117424 GO:0071933 Arp2/3 complex binding 5/3699 14/18639 0.357142857142857 1.79961765728189 0.126459814723022 0.372394146117424 GO:0004435 phosphatidylinositol phospholipase C activity 8/3699 26/18639 0.307692307692308 1.55043982781209 0.126726637139624 0.372394146117424 GO:0019865 immunoglobulin binding 8/3699 26/18639 0.307692307692308 1.55043982781209 0.126726637139624 0.372394146117424 GO:0019199 transmembrane receptor protein kinase activity 20/3699 78/18639 0.256410256410256 1.29203318984341 0.127700099468043 0.372394146117424 GO:0000287 magnesium ion binding 53/3699 230/18639 0.230434782608696 1.16114461017666 0.127915053602487 0.372394146117424 GO:0008093 cytoskeletal anchor activity 7/3699 22/18639 0.318181818181818 1.60329573103296 0.128703343575448 0.372394146117424 GO:0050321 tau-protein kinase activity 7/3699 22/18639 0.318181818181818 1.60329573103296 0.128703343575448 0.372394146117424 GO:0140035 ubiquitin-like protein reader activity 7/3699 22/18639 0.318181818181818 1.60329573103296 0.128703343575448 0.372394146117424 GO:0000900 mRNA regulatory element binding translation repressor activity 6/3699 18/18639 0.333333333333333 1.67964314679643 0.12905575572782 0.372394146117424 GO:0015172 acidic amino acid transmembrane transporter activity 6/3699 18/18639 0.333333333333333 1.67964314679643 0.12905575572782 0.372394146117424 GO:0017075 syntaxin-1 binding 6/3699 18/18639 0.333333333333333 1.67964314679643 0.12905575572782 0.372394146117424 GO:0050811 GABA receptor binding 6/3699 18/18639 0.333333333333333 1.67964314679643 0.12905575572782 0.372394146117424 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 6/3699 18/18639 0.333333333333333 1.67964314679643 0.12905575572782 0.372394146117424 GO:0008200 ion channel inhibitor activity 12/3699 43/18639 0.27906976744186 1.40621286708538 0.129586025628273 0.373118384136578 GO:0016791 phosphatase activity 62/3699 273/18639 0.227106227106227 1.1443722538613 0.13218387057974 0.379779894826951 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 11/3699 39/18639 0.282051282051282 1.42123650882775 0.134809084898087 0.386491282025417 GO:0001046 core promoter sequence-specific DNA binding 12/3699 44/18639 0.272727272727273 1.37425348374253 0.147671474619539 0.420659040707257 GO:0016248 channel inhibitor activity 12/3699 44/18639 0.272727272727273 1.37425348374253 0.147671474619539 0.420659040707257 GO:0043014 alpha-tubulin binding 12/3699 44/18639 0.272727272727273 1.37425348374253 0.147671474619539 0.420659040707257 GO:0016298 lipase activity 31/3699 130/18639 0.238461538461538 1.20159086655437 0.149967552032773 0.426290743650606 GO:0035255 ionotropic glutamate receptor binding 8/3699 27/18639 0.296296296296296 1.49301613048572 0.150382520785211 0.426562734116863 GO:0016757 glycosyltransferase activity 60/3699 267/18639 0.224719101123595 1.1323436944695 0.157038007969696 0.434335388652992 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0016176 superoxide-generating NADPH oxidase activator activity 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0019107 myristoyltransferase activity 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0019206 nucleoside kinase activity 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0032794 GTPase activating protein binding 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0043522 leucine zipper domain binding 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0045294 alpha-catenin binding 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0048185 activin binding 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0140537 transcription regulator activator activity 4/3699 11/18639 0.363636363636364 1.83233797832338 0.157674149323878 0.434335388652992 GO:0015245 fatty acid transmembrane transporter activity 6/3699 19/18639 0.315789473684211 1.59124087591241 0.158558967063917 0.435874032916447 GO:0016763 pentosyltransferase activity 13/3699 49/18639 0.26530612244898 1.33685883112369 0.159210300724372 0.436756177197401 GO:0047372 monoacylglycerol lipase activity 5/3699 15/18639 0.333333333333333 1.67964314679643 0.160187520079885 0.436756177197401 GO:0048531 beta-1,3-galactosyltransferase activity 5/3699 15/18639 0.333333333333333 1.67964314679643 0.160187520079885 0.436756177197401 GO:0050780 dopamine receptor binding 5/3699 15/18639 0.333333333333333 1.67964314679643 0.160187520079885 0.436756177197401 GO:0008009 chemokine activity 12/3699 45/18639 0.266666666666667 1.34371451743714 0.167004117700066 0.454414462825434 GO:0015101 organic cation transmembrane transporter activity 20/3699 81/18639 0.246913580246914 1.2441801087381 0.168634620821377 0.457918401254795 GO:0001530 lipopolysaccharide binding 11/3699 41/18639 0.268292682926829 1.35190789864103 0.175279435770265 0.474035073257234 GO:0042287 MHC protein binding 11/3699 41/18639 0.268292682926829 1.35190789864103 0.175279435770265 0.474035073257234 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 22/3699 91/18639 0.241758241758242 1.21820272185236 0.180941533755091 0.48835937191273 GO:0019957 C-C chemokine binding 7/3699 24/18639 0.291666666666667 1.46968775344688 0.183437974086892 0.491128523807792 GO:0030215 semaphorin receptor binding 7/3699 24/18639 0.291666666666667 1.46968775344688 0.183437974086892 0.491128523807792 GO:0070300 phosphatidic acid binding 7/3699 24/18639 0.291666666666667 1.46968775344688 0.183437974086892 0.491128523807792 GO:0140033 acetylation-dependent protein binding 7/3699 24/18639 0.291666666666667 1.46968775344688 0.183437974086892 0.491128523807792 GO:0019213 deacetylase activity 10/3699 37/18639 0.27027027027027 1.36187282172684 0.184072804232663 0.491842532909677 GO:0033218 amide binding 55/3699 247/18639 0.222672064777328 1.12202882275875 0.188330892075649 0.501215282496149 GO:0042393 histone binding 55/3699 247/18639 0.222672064777328 1.12202882275875 0.188330892075649 0.501215282496149 GO:0019239 deaminase activity 9/3699 33/18639 0.272727272727273 1.37425348374253 0.193420029146468 0.510273283535577 GO:0052689 carboxylic ester hydrolase activity 22/3699 92/18639 0.239130434782609 1.20496138791918 0.195663135005482 0.510273283535577 GO:0004707 MAP kinase activity 5/3699 16/18639 0.3125 1.57466545012165 0.197057441660395 0.510273283535577 GO:0005024 transforming growth factor beta receptor activity 5/3699 16/18639 0.3125 1.57466545012165 0.197057441660395 0.510273283535577 GO:0005324 long-chain fatty acid transmembrane transporter activity 5/3699 16/18639 0.3125 1.57466545012165 0.197057441660395 0.510273283535577 GO:0034450 ubiquitin-ubiquitin ligase activity 5/3699 16/18639 0.3125 1.57466545012165 0.197057441660395 0.510273283535577 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 5/3699 16/18639 0.3125 1.57466545012165 0.197057441660395 0.510273283535577 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 5/3699 16/18639 0.3125 1.57466545012165 0.197057441660395 0.510273283535577 GO:0008307 structural constituent of muscle 11/3699 42/18639 0.261904761904762 1.31971961534005 0.197450023901307 0.510273283535577 GO:0004714 transmembrane receptor protein tyrosine kinase activity 15/3699 60/18639 0.25 1.25973236009732 0.197494698376154 0.510273283535577 GO:0098531 ligand-modulated transcription factor activity 15/3699 60/18639 0.25 1.25973236009732 0.197494698376154 0.510273283535577 GO:0005010 insulin-like growth factor receptor activity 13/3699 51/18639 0.254901960784314 1.28443299460904 0.198364657435591 0.510273283535577 GO:0005125 cytokine activity 52/3699 234/18639 0.222222222222222 1.11976209786429 0.200487529918988 0.510273283535577 GO:0003995 acyl-CoA dehydrogenase activity 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0004000 adenosine deaminase activity 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0004875 complement receptor activity 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0005095 GTPase inhibitor activity 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0008179 adenylate cyclase binding 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0008603 cAMP-dependent protein kinase regulator activity 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0034452 dynactin binding 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0035014 phosphatidylinositol 3-kinase regulator activity 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0045295 gamma-catenin binding 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/3699 12/18639 0.333333333333333 1.67964314679643 0.201282949418599 0.510273283535577 GO:0003684 damaged DNA binding 18/3699 74/18639 0.243243243243243 1.22568553955415 0.202789189720658 0.513118101262877 GO:0016417 S-acyltransferase activity 8/3699 29/18639 0.275862068965517 1.39004950079705 0.203351027519356 0.513567056268167 GO:0160215 deacylase activity 16/3699 65/18639 0.246153846153846 1.24035186224967 0.205781358210501 0.518724329375903 GO:0031406 carboxylic acid binding 42/3699 187/18639 0.224598930481283 1.13173816308209 0.207492258800802 0.521732989505988 GO:0042887 amide transmembrane transporter activity 10/3699 38/18639 0.263157894736842 1.32603406326034 0.208146469615787 0.521732989505988 GO:0043531 ADP binding 10/3699 38/18639 0.263157894736842 1.32603406326034 0.208146469615787 0.521732989505988 GO:0019211 phosphatase activator activity 7/3699 25/18639 0.28 1.410900243309 0.213877986039648 0.535031901795669 GO:0015631 tubulin binding 83/3699 385/18639 0.215584415584416 1.08631465857743 0.214253044506499 0.535031901795669 GO:0030332 cyclin binding 9/3699 34/18639 0.264705882352941 1.33383426363246 0.219710510469052 0.546616837963974 GO:0052866 phosphatidylinositol phosphate phosphatase activity 9/3699 34/18639 0.264705882352941 1.33383426363246 0.219710510469052 0.546616837963974 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6/3699 21/18639 0.285714285714286 1.43969412582551 0.224967119282142 0.557617943155735 GO:0072542 protein phosphatase activator activity 6/3699 21/18639 0.285714285714286 1.43969412582551 0.224967119282142 0.557617943155735 GO:0016410 N-acyltransferase activity 22/3699 94/18639 0.234042553191489 1.17932391158047 0.226795286681476 0.561108338900837 GO:0043177 organic acid binding 42/3699 189/18639 0.222222222222222 1.11976209786429 0.229604329073613 0.567008102850919 GO:0001965 G-protein alpha-subunit binding 8/3699 30/18639 0.266666666666667 1.34371451743714 0.232270098612699 0.572532936801782 GO:0017110 nucleoside diphosphate phosphatase activity 5/3699 17/18639 0.294117647058824 1.48203807070273 0.236466134085563 0.578434476222298 GO:0030169 low-density lipoprotein particle binding 5/3699 17/18639 0.294117647058824 1.48203807070273 0.236466134085563 0.578434476222298 GO:0038191 neuropilin binding 5/3699 17/18639 0.294117647058824 1.48203807070273 0.236466134085563 0.578434476222298 GO:0070403 NAD+ binding 5/3699 17/18639 0.294117647058824 1.48203807070273 0.236466134085563 0.578434476222298 GO:0015179 L-amino acid transmembrane transporter activity 15/3699 62/18639 0.241935483870968 1.21909583235225 0.2368290856988 0.578434476222298 GO:0004866 endopeptidase inhibitor activity 36/3699 161/18639 0.22360248447205 1.1267171419504 0.237575105126088 0.579197701548272 GO:0004620 phospholipase activity 25/3699 109/18639 0.229357798165138 1.15571776155718 0.240928329019923 0.583550478427034 GO:0004864 protein phosphatase inhibitor activity 13/3699 53/18639 0.245283018867925 1.23596382500115 0.241398695886291 0.583550478427034 GO:0038064 collagen receptor activity 13/3699 53/18639 0.245283018867925 1.23596382500115 0.241398695886291 0.583550478427034 GO:1901505 carbohydrate derivative transmembrane transporter activity 13/3699 53/18639 0.245283018867925 1.23596382500115 0.241398695886291 0.583550478427034 GO:0046982 protein heterodimerization activity 79/3699 369/18639 0.214092140921409 1.07879519184486 0.241544471983645 0.583550478427034 GO:0001637 G protein-coupled chemoattractant receptor activity 7/3699 26/18639 0.269230769230769 1.35663484933558 0.245986377739656 0.586170349723262 GO:0004950 chemokine receptor activity 7/3699 26/18639 0.269230769230769 1.35663484933558 0.245986377739656 0.586170349723262 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 7/3699 26/18639 0.269230769230769 1.35663484933558 0.245986377739656 0.586170349723262 GO:0070006 metalloaminopeptidase activity 7/3699 26/18639 0.269230769230769 1.35663484933558 0.245986377739656 0.586170349723262 GO:0140566 histone reader activity 9/3699 35/18639 0.257142857142857 1.29572471324296 0.24727168298987 0.586170349723262 GO:0005338 nucleotide-sugar transmembrane transporter activity 4/3699 13/18639 0.307692307692308 1.55043982781209 0.247893897899433 0.586170349723262 GO:0008035 high-density lipoprotein particle binding 4/3699 13/18639 0.307692307692308 1.55043982781209 0.247893897899433 0.586170349723262 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 4/3699 13/18639 0.307692307692308 1.55043982781209 0.247893897899433 0.586170349723262 GO:0045159 myosin II binding 4/3699 13/18639 0.307692307692308 1.55043982781209 0.247893897899433 0.586170349723262 GO:0070123 transforming growth factor beta receptor activity, type III 4/3699 13/18639 0.307692307692308 1.55043982781209 0.247893897899433 0.586170349723262 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 4/3699 13/18639 0.307692307692308 1.55043982781209 0.247893897899433 0.586170349723262 GO:0140852 histone ubiquitin ligase activity 4/3699 13/18639 0.307692307692308 1.55043982781209 0.247893897899433 0.586170349723262 GO:0061980 regulatory RNA binding 14/3699 58/18639 0.241379310344828 1.21629331319742 0.249951658268864 0.589991900083397 GO:0042379 chemokine receptor binding 17/3699 72/18639 0.236111111111111 1.18974722898081 0.250990613724541 0.591399400239836 GO:0004407 histone deacetylase activity 6/3699 22/18639 0.272727272727273 1.37425348374253 0.261066035172152 0.611902145596482 GO:0031683 G-protein beta/gamma-subunit complex binding 6/3699 22/18639 0.272727272727273 1.37425348374253 0.261066035172152 0.611902145596482 GO:0033558 protein lysine deacetylase activity 6/3699 22/18639 0.272727272727273 1.37425348374253 0.261066035172152 0.611902145596482 GO:0016758 hexosyltransferase activity 43/3699 197/18639 0.218274111675127 1.09986784739462 0.266859255133524 0.624385227422746 GO:0004879 nuclear receptor activity 14/3699 59/18639 0.23728813559322 1.19567817229576 0.272006669150479 0.635316276197622 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 5/3699 18/18639 0.277777777777778 1.39970262233036 0.27777781806931 0.646282863669168 GO:0008409 5'-3' exonuclease activity 5/3699 18/18639 0.277777777777778 1.39970262233036 0.27777781806931 0.646282863669168 GO:0004683 calcium/calmodulin-dependent protein kinase activity 7/3699 27/18639 0.259259259259259 1.306389114175 0.279447727673713 0.646282863669168 GO:0005385 zinc ion transmembrane transporter activity 7/3699 27/18639 0.259259259259259 1.306389114175 0.279447727673713 0.646282863669168 GO:0005017 platelet-derived growth factor receptor activity 12/3699 50/18639 0.24 1.20934306569343 0.279604412575434 0.646282863669168 GO:0005019 platelet-derived growth factor beta-receptor activity 12/3699 50/18639 0.24 1.20934306569343 0.279604412575434 0.646282863669168 GO:0031072 heat shock protein binding 29/3699 131/18639 0.221374045801527 1.1154881967274 0.285996658286818 0.659916296150585 GO:0017080 sodium channel regulator activity 10/3699 41/18639 0.24390243902439 1.22900718058275 0.287051893905565 0.661209190099716 GO:0001098 basal transcription machinery binding 14/3699 60/18639 0.233333333333333 1.1757502027575 0.2946842254731 0.669155133745779 GO:0001099 basal RNA polymerase II transcription machinery binding 14/3699 60/18639 0.233333333333333 1.1757502027575 0.2946842254731 0.669155133745779 GO:0005545 1-phosphatidylinositol binding 4/3699 14/18639 0.285714285714286 1.43969412582551 0.296467531169998 0.669155133745779 GO:0008191 metalloendopeptidase inhibitor activity 4/3699 14/18639 0.285714285714286 1.43969412582551 0.296467531169998 0.669155133745779 GO:0019763 immunoglobulin receptor activity 4/3699 14/18639 0.285714285714286 1.43969412582551 0.296467531169998 0.669155133745779 GO:0034236 protein kinase A catalytic subunit binding 4/3699 14/18639 0.285714285714286 1.43969412582551 0.296467531169998 0.669155133745779 GO:0061665 SUMO ligase activity 4/3699 14/18639 0.285714285714286 1.43969412582551 0.296467531169998 0.669155133745779 GO:0070742 C2H2 zinc finger domain binding 4/3699 14/18639 0.285714285714286 1.43969412582551 0.296467531169998 0.669155133745779 GO:0098847 sequence-specific single stranded DNA binding 4/3699 14/18639 0.285714285714286 1.43969412582551 0.296467531169998 0.669155133745779 GO:1901612 cardiolipin binding 4/3699 14/18639 0.285714285714286 1.43969412582551 0.296467531169998 0.669155133745779 GO:0019783 ubiquitin-like protein peptidase activity 28/3699 127/18639 0.220472440944882 1.11094507347166 0.298496524143057 0.669155133745779 GO:0004602 glutathione peroxidase activity 6/3699 23/18639 0.260869565217391 1.31450333227547 0.298515314156051 0.669155133745779 GO:0005283 amino acid:sodium symporter activity 6/3699 23/18639 0.260869565217391 1.31450333227547 0.298515314156051 0.669155133745779 GO:0016493 C-C chemokine receptor activity 6/3699 23/18639 0.260869565217391 1.31450333227547 0.298515314156051 0.669155133745779 GO:0017134 fibroblast growth factor binding 6/3699 23/18639 0.260869565217391 1.31450333227547 0.298515314156051 0.669155133745779 GO:0070577 lysine-acetylated histone binding 6/3699 23/18639 0.260869565217391 1.31450333227547 0.298515314156051 0.669155133745779 GO:0004843 cysteine-type deubiquitinase activity 24/3699 108/18639 0.222222222222222 1.11976209786429 0.30226705354255 0.675298969118473 GO:0005496 steroid binding 24/3699 108/18639 0.222222222222222 1.11976209786429 0.30226705354255 0.675298969118473 GO:0005021 vascular endothelial growth factor receptor activity 12/3699 51/18639 0.235294117647059 1.18563045656219 0.304601260310769 0.678245472958647 GO:0030544 Hsp70 protein binding 12/3699 51/18639 0.235294117647059 1.18563045656219 0.304601260310769 0.678245472958647 GO:0019212 phosphatase inhibitor activity 13/3699 56/18639 0.232142857142857 1.16975147723323 0.311669623765179 0.684207827981733 GO:0045499 chemorepellent activity 7/3699 28/18639 0.25 1.25973236009732 0.313935385936776 0.684207827981733 GO:0051959 dynein light intermediate chain binding 7/3699 28/18639 0.25 1.25973236009732 0.313935385936776 0.684207827981733 GO:0035198 miRNA binding 10/3699 42/18639 0.238095238095238 1.19974510485459 0.315052478281896 0.684207827981733 GO:0042056 chemoattractant activity 10/3699 42/18639 0.238095238095238 1.19974510485459 0.315052478281896 0.684207827981733 GO:0043175 RNA polymerase core enzyme binding 10/3699 42/18639 0.238095238095238 1.19974510485459 0.315052478281896 0.684207827981733 GO:0001094 TFIID-class transcription factor complex binding 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0005345 purine nucleobase transmembrane transporter activity 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0008190 eukaryotic initiation factor 4E binding 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0015279 store-operated calcium channel activity 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0016868 intramolecular phosphotransferase activity 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0031434 mitogen-activated protein kinase kinase binding 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0043422 protein kinase B binding 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0050815 phosphoserine residue binding 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0070097 delta-catenin binding 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0140999 histone H3K4 trimethyltransferase activity 3/3699 10/18639 0.3 1.51167883211679 0.31752159681787 0.684207827981733 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/3699 19/18639 0.263157894736842 1.32603406326034 0.320355979142665 0.685890365600321 GO:0008574 plus-end-directed microtubule motor activity 5/3699 19/18639 0.263157894736842 1.32603406326034 0.320355979142665 0.685890365600321 GO:0030506 ankyrin binding 5/3699 19/18639 0.263157894736842 1.32603406326034 0.320355979142665 0.685890365600321 GO:0097001 ceramide binding 5/3699 19/18639 0.263157894736842 1.32603406326034 0.320355979142665 0.685890365600321 GO:0005504 fatty acid binding 11/3699 47/18639 0.234042553191489 1.17932391158047 0.323178175402837 0.690238362751481 GO:0008235 metalloexopeptidase activity 15/3699 66/18639 0.227272727272727 1.14521123645211 0.323420071169481 0.690238362751481 GO:0042162 telomeric DNA binding 9/3699 38/18639 0.236842105263158 1.19343065693431 0.335625087794831 0.715143727741458 GO:0001091 RNA polymerase II general transcription initiation factor binding 6/3699 24/18639 0.25 1.25973236009732 0.336874427512438 0.715523426322125 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 6/3699 24/18639 0.25 1.25973236009732 0.336874427512438 0.715523426322125 GO:0101005 deubiquitinase activity 25/3699 115/18639 0.217391304347826 1.09541944356289 0.339834221500022 0.720664317339729 GO:0004712 protein serine/threonine/tyrosine kinase activity 10/3699 43/18639 0.232558139534884 1.17184405590449 0.343620419183179 0.727538637129521 GO:0030414 peptidase inhibitor activity 36/3699 169/18639 0.21301775147929 1.07338141925452 0.345994285401265 0.728012486376502 GO:0015929 hexosaminidase activity 4/3699 15/18639 0.266666666666667 1.34371451743714 0.346023898839131 0.728012486376502 GO:0031005 filamin binding 4/3699 15/18639 0.266666666666667 1.34371451743714 0.346023898839131 0.728012486376502 GO:0140776 protein-containing complex destabilizing activity 4/3699 15/18639 0.266666666666667 1.34371451743714 0.346023898839131 0.728012486376502 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 7/3699 29/18639 0.241379310344828 1.21629331319742 0.349121318160501 0.732223047193766 GO:0097472 cyclin-dependent protein kinase activity 7/3699 29/18639 0.241379310344828 1.21629331319742 0.349121318160501 0.732223047193766 GO:0008376 acetylgalactosaminyltransferase activity 8/3699 34/18639 0.235294117647059 1.18563045656219 0.358636442398023 0.748653573505872 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 8/3699 34/18639 0.235294117647059 1.18563045656219 0.358636442398023 0.748653573505872 GO:0051427 hormone receptor binding 8/3699 34/18639 0.235294117647059 1.18563045656219 0.358636442398023 0.748653573505872 GO:0001972 retinoic acid binding 5/3699 20/18639 0.25 1.25973236009732 0.363588743236603 0.753334956942749 GO:0015095 magnesium ion transmembrane transporter activity 5/3699 20/18639 0.25 1.25973236009732 0.363588743236603 0.753334956942749 GO:0052745 inositol phosphate phosphatase activity 5/3699 20/18639 0.25 1.25973236009732 0.363588743236603 0.753334956942749 GO:0061608 nuclear import signal receptor activity 5/3699 20/18639 0.25 1.25973236009732 0.363588743236603 0.753334956942749 GO:0043178 alcohol binding 20/3699 92/18639 0.217391304347826 1.09541944356289 0.363698388643767 0.753334956942749 GO:0019205 nucleobase-containing compound kinase activity 10/3699 44/18639 0.227272727272727 1.14521123645211 0.372583128883025 0.754630003936345 GO:0003707 nuclear steroid receptor activity 6/3699 25/18639 0.24 1.20934306569343 0.375715409030161 0.754630003936345 GO:0008483 transaminase activity 6/3699 25/18639 0.24 1.20934306569343 0.375715409030161 0.754630003936345 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 6/3699 25/18639 0.24 1.20934306569343 0.375715409030161 0.754630003936345 GO:0001851 complement component C3b binding 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0005225 volume-sensitive anion channel activity 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0008199 ferric iron binding 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0015205 nucleobase transmembrane transporter activity 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0047676 arachidonate-CoA ligase activity 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0048407 platelet-derived growth factor binding 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0070697 activin receptor binding 3/3699 11/18639 0.272727272727273 1.37425348374253 0.377464389628117 0.754630003936345 GO:0005004 GPI-linked ephrin receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0005008 hepatocyte growth factor receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0005009 insulin receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0005011 macrophage colony-stimulating factor receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0005018 platelet-derived growth factor alpha-receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0005020 stem cell factor receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0008288 boss receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0035254 glutamate receptor binding 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0036332 placental growth factor receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0038062 protein tyrosine kinase collagen receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0060175 brain-derived neurotrophic factor receptor activity 11/3699 49/18639 0.224489795918367 1.13118824172005 0.37787984478549 0.754630003936345 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 12/3699 54/18639 0.222222222222222 1.11976209786429 0.382403448618177 0.761387492330677 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 12/3699 54/18639 0.222222222222222 1.11976209786429 0.382403448618177 0.761387492330677 GO:0031210 phosphatidylcholine binding 7/3699 30/18639 0.233333333333333 1.1757502027575 0.384684732805484 0.764789885458521 GO:0008201 heparin binding 36/3699 172/18639 0.209302325581395 1.05465965031404 0.389797967335602 0.773803988648386 GO:0005343 organic acid:sodium symporter activity 8/3699 35/18639 0.228571428571429 1.15175530066041 0.391633408148586 0.776294114668415 GO:0000062 fatty-acyl-CoA binding 4/3699 16/18639 0.25 1.25973236009732 0.395679384565376 0.780838490072884 GO:0004708 MAP kinase kinase activity 4/3699 16/18639 0.25 1.25973236009732 0.395679384565376 0.780838490072884 GO:0140327 flippase activity 4/3699 16/18639 0.25 1.25973236009732 0.395679384565376 0.780838490072884 GO:0004532 RNA exonuclease activity 9/3699 40/18639 0.225 1.13375912408759 0.397199000676615 0.782681216672503 GO:0033293 monocarboxylic acid binding 17/3699 79/18639 0.215189873417722 1.0843265884382 0.397858010437281 0.782825186957596 GO:0140303 intramembrane lipid transporter activity 10/3699 45/18639 0.222222222222222 1.11976209786429 0.401770081803671 0.789360043073096 GO:0005201 extracellular matrix structural constituent 35/3699 168/18639 0.208333333333333 1.04977696674777 0.403833135162317 0.792221741807699 GO:0005006 epidermal growth factor receptor activity 11/3699 50/18639 0.22 1.10856447688564 0.405598556434481 0.792221741807699 GO:0005007 fibroblast growth factor receptor activity 11/3699 50/18639 0.22 1.10856447688564 0.405598556434481 0.792221741807699 GO:0048020 CCR chemokine receptor binding 11/3699 50/18639 0.22 1.10856447688564 0.405598556434481 0.792221741807699 GO:0035613 RNA stem-loop binding 5/3699 21/18639 0.238095238095238 1.19974510485459 0.406908000722373 0.793619107978234 GO:0005112 Notch binding 6/3699 26/18639 0.230769230769231 1.16282987085907 0.414634118417312 0.806333598552444 GO:0030247 polysaccharide binding 6/3699 26/18639 0.230769230769231 1.16282987085907 0.414634118417312 0.806333598552444 GO:0008028 monocarboxylic acid transmembrane transporter activity 15/3699 70/18639 0.214285714285714 1.07977059436913 0.416256186731276 0.808311432373524 GO:0008327 methyl-CpG binding 7/3699 31/18639 0.225806451612903 1.1378227768621 0.420319335434535 0.815016882642292 GO:0000993 RNA polymerase II complex binding 8/3699 36/18639 0.222222222222222 1.11976209786429 0.424696442323908 0.817323832514918 GO:0004033 aldo-keto reductase (NADPH) activity 8/3699 36/18639 0.222222222222222 1.11976209786429 0.424696442323908 0.817323832514918 GO:0004869 cysteine-type endopeptidase inhibitor activity 8/3699 36/18639 0.222222222222222 1.11976209786429 0.424696442323908 0.817323832514918 GO:0004180 carboxypeptidase activity 10/3699 46/18639 0.217391304347826 1.09541944356289 0.431015505951396 0.817323832514918 GO:0005030 neurotrophin receptor activity 11/3699 51/18639 0.215686274509804 1.08682791851534 0.433372812868501 0.817323832514918 GO:0030170 pyridoxal phosphate binding 12/3699 56/18639 0.214285714285714 1.07977059436913 0.435361030021239 0.817323832514918 GO:0170055 lipid transmembrane transporter activity 12/3699 56/18639 0.214285714285714 1.07977059436913 0.435361030021239 0.817323832514918 GO:0000340 RNA 7-methylguanosine cap binding 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0005025 transforming growth factor beta receptor activity, type I 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0005026 transforming growth factor beta receptor activity, type II 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0005247 voltage-gated chloride channel activity 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0008504 monoamine transmembrane transporter activity 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0016208 AMP binding 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0016273 arginine N-methyltransferase activity 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0016274 protein-arginine N-methyltransferase activity 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0016361 activin receptor activity, type I 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0016362 activin receptor activity, type II 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0017002 activin receptor activity 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0035251 UDP-glucosyltransferase activity 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0042301 phosphate ion binding 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0043047 single-stranded telomeric DNA binding 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0070679 inositol 1,4,5 trisphosphate binding 3/3699 12/18639 0.25 1.25973236009732 0.436191536364623 0.817323832514918 GO:0050660 flavin adenine dinucleotide binding 18/3699 86/18639 0.209302325581395 1.05465965031404 0.442770736703129 0.8262538955489 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4/3699 17/18639 0.235294117647059 1.18563045656219 0.444668077020703 0.8262538955489 GO:0015278 intracellularly gated calcium channel activity 4/3699 17/18639 0.235294117647059 1.18563045656219 0.444668077020703 0.8262538955489 GO:0016805 dipeptidase activity 4/3699 17/18639 0.235294117647059 1.18563045656219 0.444668077020703 0.8262538955489 GO:0032977 membrane insertase activity 4/3699 17/18639 0.235294117647059 1.18563045656219 0.444668077020703 0.8262538955489 GO:1901567 fatty acid derivative binding 4/3699 17/18639 0.235294117647059 1.18563045656219 0.444668077020703 0.8262538955489 GO:0015377 chloride:monoatomic cation symporter activity 5/3699 22/18639 0.227272727272727 1.14521123645211 0.449802696472437 0.83347628638998 GO:0140517 protein-RNA adaptor activity 5/3699 22/18639 0.227272727272727 1.14521123645211 0.449802696472437 0.83347628638998 GO:0008266 poly(U) RNA binding 6/3699 27/18639 0.222222222222222 1.11976209786429 0.453258801486912 0.836400219318391 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 6/3699 27/18639 0.222222222222222 1.11976209786429 0.453258801486912 0.836400219318391 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 6/3699 27/18639 0.222222222222222 1.11976209786429 0.453258801486912 0.836400219318391 GO:0004520 DNA endonuclease activity 9/3699 42/18639 0.214285714285714 1.07977059436913 0.45903025523072 0.844716833317138 GO:0019894 kinesin binding 9/3699 42/18639 0.214285714285714 1.07977059436913 0.45903025523072 0.844716833317138 GO:0070279 vitamin B6 binding 12/3699 57/18639 0.210526315789474 1.06082725060827 0.461801069305749 0.848646806867237 GO:0005548 phospholipid transporter activity 14/3699 68/18639 0.205882352941176 1.03742664949191 0.487134920386844 0.881153395020058 GO:0005507 copper ion binding 13/3699 63/18639 0.206349206349206 1.03977909087398 0.487591449195152 0.881153395020058 GO:1901682 sulfur compound transmembrane transporter activity 13/3699 63/18639 0.206349206349206 1.03977909087398 0.487591449195152 0.881153395020058 GO:0005003 ephrin receptor activity 11/3699 53/18639 0.207547169811321 1.04581554423174 0.488550873064477 0.881153395020058 GO:0005005 transmembrane-ephrin receptor activity 11/3699 53/18639 0.207547169811321 1.04581554423174 0.488550873064477 0.881153395020058 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 8/3699 38/18639 0.210526315789474 1.06082725060827 0.490122541791123 0.881153395020058 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 7/3699 33/18639 0.212121212121212 1.06886382068864 0.490682924380603 0.881153395020058 GO:0016854 racemase and epimerase activity 4/3699 18/18639 0.222222222222222 1.11976209786429 0.492351008149672 0.881153395020058 GO:0017128 phospholipid scramblase activity 4/3699 18/18639 0.222222222222222 1.11976209786429 0.492351008149672 0.881153395020058 GO:0031690 adrenergic receptor binding 4/3699 18/18639 0.222222222222222 1.11976209786429 0.492351008149672 0.881153395020058 GO:0070628 proteasome binding 4/3699 18/18639 0.222222222222222 1.11976209786429 0.492351008149672 0.881153395020058 GO:1901611 phosphatidylglycerol binding 4/3699 18/18639 0.222222222222222 1.11976209786429 0.492351008149672 0.881153395020058 GO:0005172 vascular endothelial growth factor receptor binding 3/3699 13/18639 0.230769230769231 1.16282987085907 0.492680827904179 0.881153395020058 GO:0005542 folic acid binding 3/3699 13/18639 0.230769230769231 1.16282987085907 0.492680827904179 0.881153395020058 GO:0031432 titin binding 3/3699 13/18639 0.230769230769231 1.16282987085907 0.492680827904179 0.881153395020058 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/3699 13/18639 0.230769230769231 1.16282987085907 0.492680827904179 0.881153395020058 GO:0061459 L-arginine transmembrane transporter activity 3/3699 13/18639 0.230769230769231 1.16282987085907 0.492680827904179 0.881153395020058 GO:0071714 icosanoid transmembrane transporter activity 3/3699 13/18639 0.230769230769231 1.16282987085907 0.492680827904179 0.881153395020058 GO:0071837 HMG box domain binding 3/3699 13/18639 0.230769230769231 1.16282987085907 0.492680827904179 0.881153395020058 GO:0097157 pre-mRNA intronic binding 3/3699 13/18639 0.230769230769231 1.16282987085907 0.492680827904179 0.881153395020058 GO:0003727 single-stranded RNA binding 18/3699 89/18639 0.202247191011236 1.01910932502255 0.506592943246376 0.904823759595132 GO:0004536 DNA nuclease activity 13/3699 64/18639 0.203125 1.02353254257908 0.512533852394749 0.914212585846976 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 12/3699 59/18639 0.203389830508475 1.02486700482494 0.514040664307755 0.915677770020214 GO:0050661 NADP binding 11/3699 54/18639 0.203703703703704 1.02644858970893 0.515704865364693 0.916199069318125 GO:0051287 NAD binding 11/3699 54/18639 0.203703703703704 1.02644858970893 0.515704865364693 0.916199069318125 GO:0016790 thiolester hydrolase activity 9/3699 44/18639 0.204545454545455 1.0306901128069 0.519664806270402 0.922008208734737 GO:0016776 phosphotransferase activity, phosphate group as acceptor 8/3699 39/18639 0.205128205128205 1.03362655187473 0.522081379093797 0.925067271179459 GO:0005539 glycosaminoglycan binding 48/3699 242/18639 0.198347107438017 0.99945707908548 0.527695933795805 0.933670906471554 GO:0005416 amino acid:monoatomic cation symporter activity 6/3699 29/18639 0.206896551724138 1.04253712559779 0.52833473450037 0.933670906471554 GO:0015295 solute:proton symporter activity 5/3699 24/18639 0.208333333333333 1.04977696674777 0.532603954029063 0.9350546717237 GO:0070840 dynein complex binding 5/3699 24/18639 0.208333333333333 1.04977696674777 0.532603954029063 0.9350546717237 GO:0120013 lipid transfer activity 13/3699 65/18639 0.2 1.00778588807786 0.537140453739903 0.9350546717237 GO:0005229 intracellularly calcium-gated chloride channel activity 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0005346 purine ribonucleotide transmembrane transporter activity 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0008301 DNA binding, bending 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0031420 alkali metal ion binding 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0042800 histone H3K4 methyltransferase activity 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0042834 peptidoglycan binding 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0046527 glucosyltransferase activity 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0050145 nucleoside monophosphate kinase activity 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0120227 acyl-CoA binding 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0141147 intracellularly calcium-gated channel activity 4/3699 19/18639 0.210526315789474 1.06082725060827 0.538216349218208 0.9350546717237 GO:0015605 organophosphate ester transmembrane transporter activity 10/3699 50/18639 0.2 1.00778588807786 0.545554005838656 0.935531508180701 GO:0004705 JUN kinase activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0005313 L-glutamate transmembrane transporter activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0008474 palmitoyl-(protein) hydrolase activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0015386 potassium:proton antiporter activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0015926 glucosidase activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0016530 metallochaperone activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0042813 Wnt receptor activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0098599 palmitoyl hydrolase activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0098821 BMP receptor activity 3/3699 14/18639 0.214285714285714 1.07977059436913 0.546193545195319 0.935531508180701 GO:0016209 antioxidant activity 17/3699 86/18639 0.197674418604651 0.996067447518814 0.550468641622298 0.941646741622779 GO:0050997 quaternary ammonium group binding 8/3699 40/18639 0.2 1.00778588807786 0.553301973698092 0.944075909145148 GO:0071949 FAD binding 8/3699 40/18639 0.2 1.00778588807786 0.553301973698092 0.944075909145148 GO:0005319 lipid transporter activity 35/3699 178/18639 0.196629213483146 0.990800732660816 0.554647864388569 0.945165238294806 GO:0000175 3'-5'-RNA exonuclease activity 7/3699 35/18639 0.2 1.00778588807786 0.558238144821851 0.950071543289163 GO:0015171 amino acid transmembrane transporter activity 20/3699 102/18639 0.196078431372549 0.988025380468489 0.563745634424528 0.955080914488459 GO:0008106 alcohol dehydrogenase (NADP+) activity 6/3699 30/18639 0.2 1.00778588807786 0.564247234924092 0.955080914488459 GO:0008187 poly-pyrimidine tract binding 6/3699 30/18639 0.2 1.00778588807786 0.564247234924092 0.955080914488459 GO:0016769 transferase activity, transferring nitrogenous groups 6/3699 30/18639 0.2 1.00778588807786 0.564247234924092 0.955080914488459 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 12/3699 61/18639 0.19672131147541 0.991264807945435 0.564755929974463 0.955080914488459 GO:0008139 nuclear localization sequence binding 5/3699 25/18639 0.2 1.00778588807786 0.57182609027879 0.96278591691669 GO:0015296 monoatomic anion:monoatomic cation symporter activity 5/3699 25/18639 0.2 1.00778588807786 0.57182609027879 0.96278591691669 GO:0047617 fatty acyl-CoA hydrolase activity 5/3699 25/18639 0.2 1.00778588807786 0.57182609027879 0.96278591691669 GO:0003743 translation initiation factor activity 10/3699 51/18639 0.196078431372549 0.988025380468489 0.572915272416743 0.96278591691669 GO:0016597 amino acid binding 10/3699 51/18639 0.196078431372549 0.988025380468489 0.572915272416743 0.96278591691669 GO:0000339 RNA cap binding 4/3699 20/18639 0.2 1.00778588807786 0.581873250713609 0.971428339346236 GO:0005326 neurotransmitter transmembrane transporter activity 4/3699 20/18639 0.2 1.00778588807786 0.581873250713609 0.971428339346236 GO:0016505 peptidase activator activity involved in apoptotic process 4/3699 20/18639 0.2 1.00778588807786 0.581873250713609 0.971428339346236 GO:0043024 ribosomal small subunit binding 4/3699 20/18639 0.2 1.00778588807786 0.581873250713609 0.971428339346236 GO:0005253 monoatomic anion channel activity 20/3699 103/18639 0.194174757281553 0.978432901046465 0.582894929806192 0.971428339346236 GO:0140318 protein transporter activity 8/3699 41/18639 0.195121951219512 0.983205744466204 0.583635088665879 0.971428339346236 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 13/3699 67/18639 0.194029850746269 0.977702727239714 0.58502667989917 0.971428339346236 GO:0141108 transporter regulator activity 33/3699 170/18639 0.194117647058824 0.978145126663804 0.587369394943706 0.971428339346236 GO:0004190 aspartic-type endopeptidase activity 7/3699 36/18639 0.194444444444444 0.979791835631252 0.590472348873079 0.971428339346236 GO:0045505 dynein intermediate chain binding 7/3699 36/18639 0.194444444444444 0.979791835631252 0.590472348873079 0.971428339346236 GO:0099106 ion channel regulator activity 31/3699 160/18639 0.19375 0.976292579075426 0.591207768653393 0.971428339346236 GO:0004601 peroxidase activity 11/3699 57/18639 0.192982456140351 0.97242497972425 0.594122051298695 0.971428339346236 GO:0015932 nucleobase-containing compound transmembrane transporter activity 11/3699 57/18639 0.192982456140351 0.97242497972425 0.594122051298695 0.971428339346236 GO:0005254 chloride channel activity 16/3699 83/18639 0.192771084337349 0.971359892123237 0.595550749204637 0.971428339346236 GO:0004467 long-chain fatty acid-CoA ligase activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0017081 chloride channel regulator activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0031386 protein tag activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0033130 acetylcholine receptor binding 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0045504 dynein heavy chain binding 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0141047 molecular tag activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0141050 histone H3K deacetylase activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0141051 histone H4K deacetylase activity 3/3699 15/18639 0.2 1.00778588807786 0.596235956784367 0.971428339346236 GO:0017147 Wnt-protein binding 6/3699 31/18639 0.193548387096774 0.975276665881799 0.598789930801586 0.97440115414241 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 25/3699 130/18639 0.192307692307692 0.969024892382557 0.604956678239021 0.9749890602763 GO:0140938 histone H3 methyltransferase activity 9/3699 47/18639 0.191489361702128 0.964901382202205 0.605749877298898 0.9749890602763 GO:0030145 manganese ion binding 13/3699 68/18639 0.191176470588235 0.963324745956777 0.608164732147538 0.9749890602763 GO:0042562 hormone binding 18/3699 94/18639 0.191489361702128 0.964901382202205 0.608448932969703 0.9749890602763 GO:0008198 ferrous iron binding 5/3699 26/18639 0.192307692307692 0.969024892382557 0.609252750245808 0.9749890602763 GO:0016289 acyl-CoA hydrolase activity 5/3699 26/18639 0.192307692307692 0.969024892382557 0.609252750245808 0.9749890602763 GO:0051139 metal cation:proton antiporter activity 5/3699 26/18639 0.192307692307692 0.969024892382557 0.609252750245808 0.9749890602763 GO:0051879 Hsp90 protein binding 8/3699 42/18639 0.19047619047619 0.959796083883675 0.612953873003563 0.9749890602763 GO:0004955 prostaglandin receptor activity 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0019911 structural constituent of myelin sheath 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0031419 cobalamin binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0035256 G protein-coupled glutamate receptor binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0035374 chondroitin sulfate binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0042166 acetylcholine binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0043121 neurotrophin binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0043208 glycosphingolipid binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0043295 glutathione binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0051880 G-quadruplex DNA binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0071723 lipopeptide binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0098505 G-rich strand telomeric DNA binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0099122 RNA polymerase II C-terminal domain binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:1990757 ubiquitin ligase activator activity 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:1990763 arrestin family protein binding 2/3699 10/18639 0.2 1.00778588807786 0.61957036264478 0.9749890602763 GO:0017171 serine hydrolase activity 38/3699 198/18639 0.191919191919192 0.967067266337339 0.61993734307594 0.9749890602763 GO:0022829 wide pore channel activity 7/3699 37/18639 0.189189189189189 0.953310975208785 0.62147665247623 0.9749890602763 GO:0070001 aspartic-type peptidase activity 7/3699 37/18639 0.189189189189189 0.953310975208785 0.62147665247623 0.9749890602763 GO:0008373 sialyltransferase activity 4/3699 21/18639 0.19047619047619 0.959796083883675 0.623041544829194 0.9749890602763 GO:0015174 basic amino acid transmembrane transporter activity 4/3699 21/18639 0.19047619047619 0.959796083883675 0.623041544829194 0.9749890602763 GO:0140597 protein carrier chaperone 36/3699 188/18639 0.191489361702128 0.964901382202205 0.624069617058389 0.9749890602763 GO:0017046 peptide hormone binding 10/3699 53/18639 0.188679245283019 0.950741403847037 0.62535870740761 0.9749890602763 GO:0031491 nucleosome binding 14/3699 74/18639 0.189189189189189 0.953310975208785 0.625423371749094 0.9749890602763 GO:0048029 monosaccharide binding 14/3699 74/18639 0.189189189189189 0.953310975208785 0.625423371749094 0.9749890602763 GO:0015108 chloride transmembrane transporter activity 23/3699 121/18639 0.190082644628099 0.957813034123585 0.627613212377569 0.977262531161343 GO:0031369 translation initiation factor binding 6/3699 32/18639 0.1875 0.944799270072993 0.631801649457327 0.98149651590115 GO:0070717 poly-purine tract binding 6/3699 32/18639 0.1875 0.944799270072993 0.631801649457327 0.98149651590115 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/3699 48/18639 0.1875 0.944799270072993 0.632679195120418 0.981718240047477 GO:0004175 endopeptidase activity 78/3699 405/18639 0.192592592592593 0.970460484815716 0.637355929449676 0.985538888888509 GO:0140658 ATP-dependent chromatin remodeler activity 30/3699 158/18639 0.189873417721519 0.956758754504296 0.638458343027739 0.985538888888509 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 3/3699 16/18639 0.1875 0.944799270072993 0.642518242681057 0.985538888888509 GO:0008142 oxysterol binding 3/3699 16/18639 0.1875 0.944799270072993 0.642518242681057 0.985538888888509 GO:0015378 sodium:chloride symporter activity 3/3699 16/18639 0.1875 0.944799270072993 0.642518242681057 0.985538888888509 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/3699 16/18639 0.1875 0.944799270072993 0.642518242681057 0.985538888888509 GO:0016722 oxidoreductase activity, acting on metal ions 3/3699 16/18639 0.1875 0.944799270072993 0.642518242681057 0.985538888888509 GO:0043023 ribosomal large subunit binding 3/3699 16/18639 0.1875 0.944799270072993 0.642518242681057 0.985538888888509 GO:0097027 ubiquitin-protein transferase activator activity 3/3699 16/18639 0.1875 0.944799270072993 0.642518242681057 0.985538888888509 GO:0140328 floppase activity 3/3699 16/18639 0.1875 0.944799270072993 0.642518242681057 0.985538888888509 GO:0004364 glutathione transferase activity 5/3699 27/18639 0.185185185185185 0.933135081553573 0.644705920418284 0.987760446879389 GO:0044183 protein folding chaperone 14/3699 75/18639 0.186666666666667 0.940600162206002 0.646676150783171 0.989644143695666 GO:0005501 retinoid binding 7/3699 38/18639 0.184210526315789 0.928223844282238 0.651137258114802 0.994193573533001 GO:0019840 isoprenoid binding 7/3699 38/18639 0.184210526315789 0.928223844282238 0.651137258114802 0.994193573533001 GO:0008509 monoatomic anion transmembrane transporter activity 28/3699 149/18639 0.187919463087248 0.946912914972485 0.659009848597093 1 GO:0008970 phospholipase A1 activity 4/3699 22/18639 0.181818181818182 0.91616898916169 0.661539066686251 1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 11/3699 60/18639 0.183333333333333 0.923803730738037 0.666185747044223 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 11/3699 60/18639 0.183333333333333 0.923803730738037 0.666185747044223 1 GO:0000099 sulfur amino acid transmembrane transporter activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0003953 NAD+ nucleosidase activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0004016 adenylate cyclase activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0004954 prostanoid receptor activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0005536 D-glucose binding 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0008271 secondary active sulfate transmembrane transporter activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0008526 phosphatidylinositol transfer activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0010854 adenylate cyclase regulator activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0015173 aromatic amino acid transmembrane transporter activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0180030 inositol phosphate kinase activity 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:1900750 oligopeptide binding 2/3699 11/18639 0.181818181818182 0.91616898916169 0.673371689981817 1 GO:0046625 sphingolipid binding 5/3699 28/18639 0.178571428571429 0.899808828640945 0.678064577762052 1 GO:0050698 proteoglycan sulfotransferase activity 5/3699 28/18639 0.178571428571429 0.899808828640945 0.678064577762052 1 GO:0042626 ATPase-coupled transmembrane transporter activity 18/3699 98/18639 0.183673469387755 0.925517652316401 0.682637567580223 1 GO:0015297 antiporter activity 25/3699 135/18639 0.185185185185185 0.933135081553573 0.684259533877151 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/3699 17/18639 0.176470588235294 0.88922284242164 0.684914706751132 1 GO:0004550 nucleoside diphosphate kinase activity 3/3699 17/18639 0.176470588235294 0.88922284242164 0.684914706751132 1 GO:0045125 bioactive lipid receptor activity 3/3699 17/18639 0.176470588235294 0.88922284242164 0.684914706751132 1 GO:0045236 CXCR chemokine receptor binding 3/3699 17/18639 0.176470588235294 0.88922284242164 0.684914706751132 1 GO:0070492 oligosaccharide binding 3/3699 17/18639 0.176470588235294 0.88922284242164 0.684914706751132 1 GO:0003724 RNA helicase activity 14/3699 77/18639 0.181818181818182 0.91616898916169 0.68720495622021 1 GO:0008083 growth factor activity 30/3699 162/18639 0.185185185185185 0.933135081553573 0.694874639757261 1 GO:0000295 adenine nucleotide transmembrane transporter activity 4/3699 23/18639 0.173913043478261 0.876335554850312 0.697267929285861 1 GO:0016849 phosphorus-oxygen lyase activity 4/3699 23/18639 0.173913043478261 0.876335554850312 0.697267929285861 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/3699 23/18639 0.173913043478261 0.876335554850312 0.697267929285861 1 GO:0016500 protein-hormone receptor activity 12/3699 67/18639 0.17910447761194 0.902494825144351 0.701576695184412 1 GO:0008236 serine-type peptidase activity 36/3699 194/18639 0.185567010309278 0.935059071412446 0.70196706336073 1 GO:0016247 channel regulator activity 31/3699 168/18639 0.18452380952381 0.92980245626231 0.704806047300171 1 GO:0140662 ATP-dependent protein folding chaperone 7/3699 40/18639 0.175 0.881812652068126 0.706109559095129 1 GO:0008237 metallopeptidase activity 34/3699 184/18639 0.184782608695652 0.931106527028457 0.707925195381371 1 GO:0099604 ligand-gated calcium channel activity 5/3699 29/18639 0.172413793103448 0.868780937998154 0.709258295108236 1 GO:0003697 single-stranded DNA binding 22/3699 121/18639 0.181818181818182 0.91616898916169 0.711920255255228 1 GO:0004540 RNA nuclease activity 22/3699 121/18639 0.181818181818182 0.91616898916169 0.711920255255228 1 GO:0051082 unfolded protein binding 22/3699 121/18639 0.181818181818182 0.91616898916169 0.711920255255228 1 GO:0004527 exonuclease activity 15/3699 84/18639 0.178571428571429 0.899808828640945 0.717920632528608 1 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0015132 prostaglandin transmembrane transporter activity 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0015368 calcium:monoatomic cation antiporter activity 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0016801 hydrolase activity, acting on ether bonds 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0016803 ether hydrolase activity 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0016840 carbon-nitrogen lyase activity 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0140900 chloride:bicarbonate antiporter activity 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/3699 12/18639 0.166666666666667 0.839821573398216 0.720807720705256 1 GO:0140713 histone chaperone activity 30/3699 164/18639 0.182926829268293 0.921755385437066 0.72118180339532 1 GO:0003777 microtubule motor activity 12/3699 68/18639 0.176470588235294 0.88922284242164 0.7215935444066 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/3699 18/18639 0.166666666666667 0.839821573398216 0.723427446471425 1 GO:0008308 voltage-gated monoatomic anion channel activity 3/3699 18/18639 0.166666666666667 0.839821573398216 0.723427446471425 1 GO:0008525 phosphatidylcholine transporter activity 3/3699 18/18639 0.166666666666667 0.839821573398216 0.723427446471425 1 GO:0015373 monoatomic anion:sodium symporter activity 3/3699 18/18639 0.166666666666667 0.839821573398216 0.723427446471425 1 GO:0008186 ATP-dependent activity, acting on RNA 14/3699 79/18639 0.177215189873418 0.892974837537343 0.724893018763216 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 22/3699 122/18639 0.180327868852459 0.908659407283316 0.72678493724769 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 9/3699 52/18639 0.173076923076923 0.872122403144301 0.729568264507863 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/3699 24/18639 0.166666666666667 0.839821573398216 0.730200724337221 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/3699 24/18639 0.166666666666667 0.839821573398216 0.730200724337221 1 GO:0030552 cAMP binding 4/3699 24/18639 0.166666666666667 0.839821573398216 0.730200724337221 1 GO:0140828 metal cation:monoatomic cation antiporter activity 7/3699 41/18639 0.170731707317073 0.860305026407928 0.731324891242328 1 GO:0033612 receptor serine/threonine kinase binding 5/3699 30/18639 0.166666666666667 0.839821573398216 0.738260507145065 1 GO:0008408 3'-5' exonuclease activity 10/3699 58/18639 0.172413793103448 0.868780937998154 0.740032826944263 1 GO:0015291 secondary active transmembrane transporter activity 53/3699 287/18639 0.184668989547038 0.930534008155514 0.744237369064929 1 GO:0005246 calcium channel regulator activity 9/3699 53/18639 0.169811320754717 0.855667263462333 0.750883855732915 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 9/3699 53/18639 0.169811320754717 0.855667263462333 0.750883855732915 1 GO:0046943 carboxylic acid transmembrane transporter activity 34/3699 188/18639 0.180851063829787 0.911295749857638 0.755137785169586 1 GO:0003756 protein disulfide isomerase activity 3/3699 19/18639 0.157894736842105 0.795620437956204 0.758154527206403 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/3699 19/18639 0.157894736842105 0.795620437956204 0.758154527206403 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/3699 19/18639 0.157894736842105 0.795620437956204 0.758154527206403 1 GO:0022821 solute:potassium antiporter activity 3/3699 19/18639 0.157894736842105 0.795620437956204 0.758154527206403 1 GO:0034987 immunoglobulin receptor binding 3/3699 19/18639 0.157894736842105 0.795620437956204 0.758154527206403 1 GO:0046624 sphingolipid transporter activity 3/3699 19/18639 0.157894736842105 0.795620437956204 0.758154527206403 1 GO:0070003 threonine-type peptidase activity 3/3699 19/18639 0.157894736842105 0.795620437956204 0.758154527206403 1 GO:0070888 E-box binding 10/3699 59/18639 0.169491525423729 0.854055837354118 0.759838544933127 1 GO:0001848 complement binding 4/3699 25/18639 0.16 0.806228710462287 0.760367321300732 1 GO:0005537 D-mannose binding 4/3699 25/18639 0.16 0.806228710462287 0.760367321300732 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/3699 25/18639 0.16 0.806228710462287 0.760367321300732 1 GO:0004465 lipoprotein lipase activity 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0008417 fucosyltransferase activity 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0019104 DNA N-glycosylase activity 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0019855 calcium channel inhibitor activity 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0030955 potassium ion binding 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0035673 oligopeptide transmembrane transporter activity 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0046974 histone H3K9 methyltransferase activity 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0140666 annealing activity 2/3699 13/18639 0.153846153846154 0.775219913906045 0.762285337578179 1 GO:0047499 calcium-independent phospholipase A2 activity 5/3699 31/18639 0.161290322580645 0.812730554901499 0.765081771826503 1 GO:0072349 modified amino acid transmembrane transporter activity 5/3699 31/18639 0.161290322580645 0.812730554901499 0.765081771826503 1 GO:0005342 organic acid transmembrane transporter activity 34/3699 189/18639 0.17989417989418 0.906474079223471 0.766158611542469 1 GO:0140674 ATP-dependent histone chaperone activity 27/3699 152/18639 0.177631578947368 0.89507299270073 0.770164163228126 1 GO:0140299 molecular sensor activity 12/3699 71/18639 0.169014084507042 0.851650046262979 0.776331583434919 1 GO:1901681 sulfur compound binding 50/3699 275/18639 0.181818181818182 0.91616898916169 0.778466774716621 1 GO:0061775 cohesin loader activity 27/3699 153/18639 0.176470588235294 0.88922284242164 0.781900875229111 1 GO:0140104 molecular carrier activity 45/3699 249/18639 0.180722891566265 0.910649898865535 0.782379879119695 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/3699 26/18639 0.153846153846154 0.775219913906045 0.787842697856173 1 GO:0004529 DNA exonuclease activity 4/3699 26/18639 0.153846153846154 0.775219913906045 0.787842697856173 1 GO:0005227 calcium-activated cation channel activity 4/3699 26/18639 0.153846153846154 0.775219913906045 0.787842697856173 1 GO:0015216 purine nucleotide transmembrane transporter activity 4/3699 26/18639 0.153846153846154 0.775219913906045 0.787842697856173 1 GO:0030507 spectrin binding 4/3699 26/18639 0.153846153846154 0.775219913906045 0.787842697856173 1 GO:0097602 cullin family protein binding 4/3699 26/18639 0.153846153846154 0.775219913906045 0.787842697856173 1 GO:0016408 C-acyltransferase activity 3/3699 20/18639 0.15 0.755839416058394 0.789262987763955 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/3699 20/18639 0.15 0.755839416058394 0.789262987763955 1 GO:0031418 L-ascorbic acid binding 3/3699 20/18639 0.15 0.755839416058394 0.789262987763955 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/3699 32/18639 0.15625 0.787332725060827 0.789763275968943 1 GO:0140142 nucleocytoplasmic carrier activity 5/3699 32/18639 0.15625 0.787332725060827 0.789763275968943 1 GO:0008135 translation factor activity, RNA binding 14/3699 83/18639 0.168674698795181 0.849939905607833 0.791194751783616 1 GO:0008195 phosphatidate phosphatase activity 2/3699 14/18639 0.142857142857143 0.719847062912756 0.798300636308655 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/3699 14/18639 0.142857142857143 0.719847062912756 0.798300636308655 1 GO:0019992 diacylglycerol binding 2/3699 14/18639 0.142857142857143 0.719847062912756 0.798300636308655 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/3699 14/18639 0.142857142857143 0.719847062912756 0.798300636308655 1 GO:0030983 mismatched DNA binding 2/3699 14/18639 0.142857142857143 0.719847062912756 0.798300636308655 1 GO:0031404 chloride ion binding 2/3699 14/18639 0.142857142857143 0.719847062912756 0.798300636308655 1 GO:0043176 amine binding 2/3699 14/18639 0.142857142857143 0.719847062912756 0.798300636308655 1 GO:0004867 serine-type endopeptidase inhibitor activity 16/3699 95/18639 0.168421052631579 0.848661800486618 0.804678920296897 1 GO:0180051 translation factor activity 14/3699 84/18639 0.166666666666667 0.839821573398216 0.805849575634618 1 GO:0004518 nuclease activity 37/3699 209/18639 0.177033492822967 0.892059278920593 0.806188452190204 1 GO:0001846 opsonin binding 3/3699 21/18639 0.142857142857143 0.719847062912756 0.816966561586414 1 GO:0015125 bile acid transmembrane transporter activity 3/3699 21/18639 0.142857142857143 0.719847062912756 0.816966561586414 1 GO:0019200 carbohydrate kinase activity 3/3699 21/18639 0.142857142857143 0.719847062912756 0.816966561586414 1 GO:0036122 BMP binding 3/3699 21/18639 0.142857142857143 0.719847062912756 0.816966561586414 1 GO:0061891 calcium ion sensor activity 3/3699 21/18639 0.142857142857143 0.719847062912756 0.816966561586414 1 GO:0000510 H3-H4 histone complex chaperone activity 26/3699 151/18639 0.172185430463576 0.867630234769018 0.819132901925946 1 GO:0140584 chromatin extrusion motor activity 26/3699 151/18639 0.172185430463576 0.867630234769018 0.819132901925946 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 26/3699 151/18639 0.172185430463576 0.867630234769018 0.819132901925946 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 26/3699 151/18639 0.172185430463576 0.867630234769018 0.819132901925946 1 GO:0005048 signal sequence binding 8/3699 51/18639 0.156862745098039 0.790420304374791 0.820394637079408 1 GO:0015616 DNA translocase activity 26/3699 152/18639 0.171052631578947 0.861922141119221 0.829237562292163 1 GO:0004129 cytochrome-c oxidase activity 2/3699 15/18639 0.133333333333333 0.671857258718572 0.829387510081623 1 GO:0004953 icosanoid receptor activity 2/3699 15/18639 0.133333333333333 0.671857258718572 0.829387510081623 1 GO:0010181 FMN binding 2/3699 15/18639 0.133333333333333 0.671857258718572 0.829387510081623 1 GO:0015116 sulfate transmembrane transporter activity 2/3699 15/18639 0.133333333333333 0.671857258718572 0.829387510081623 1 GO:0030553 cGMP binding 2/3699 15/18639 0.133333333333333 0.671857258718572 0.829387510081623 1 GO:0140161 monocarboxylate:sodium symporter activity 2/3699 15/18639 0.133333333333333 0.671857258718572 0.829387510081623 1 GO:0015020 glucuronosyltransferase activity 5/3699 34/18639 0.147058823529412 0.741019035351367 0.832988974228837 1 GO:0090482 vitamin transmembrane transporter activity 5/3699 34/18639 0.147058823529412 0.741019035351367 0.832988974228837 1 GO:0015036 disulfide oxidoreductase activity 6/3699 40/18639 0.15 0.755839416058394 0.833101154710008 1 GO:0016866 intramolecular transferase activity 4/3699 28/18639 0.142857142857143 0.719847062912756 0.835181295902736 1 GO:0051537 2 iron, 2 sulfur cluster binding 4/3699 28/18639 0.142857142857143 0.719847062912756 0.835181295902736 1 GO:0005243 gap junction channel activity 3/3699 22/18639 0.136363636363636 0.687126741871267 0.841507744991703 1 GO:0070034 telomerase RNA binding 3/3699 22/18639 0.136363636363636 0.687126741871267 0.841507744991703 1 GO:0140784 metal ion sensor activity 3/3699 22/18639 0.136363636363636 0.687126741871267 0.841507744991703 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 22/3699 132/18639 0.166666666666667 0.839821573398216 0.848620676805764 1 GO:0140359 ABC-type transporter activity 7/3699 47/18639 0.148936170212766 0.750478852823937 0.850890215507274 1 GO:0004623 phospholipase A2 activity 5/3699 35/18639 0.142857142857143 0.719847062912756 0.851716733089337 1 GO:0016229 steroid dehydrogenase activity 5/3699 35/18639 0.142857142857143 0.719847062912756 0.851716733089337 1 GO:0003689 DNA clamp loader activity 27/3699 160/18639 0.16875 0.850319343065693 0.852744957915416 1 GO:0004519 endonuclease activity 21/3699 127/18639 0.165354330708661 0.833208805103742 0.853908140760844 1 GO:0015459 potassium channel regulator activity 9/3699 59/18639 0.152542372881356 0.768650253618706 0.854151227034798 1 GO:0004181 metallocarboxypeptidase activity 4/3699 29/18639 0.137931034482759 0.695024750398523 0.855328976029856 1 GO:0008296 3'-5'-DNA exonuclease activity 2/3699 16/18639 0.125 0.629866180048662 0.856083119710275 1 GO:0015385 sodium:proton antiporter activity 2/3699 16/18639 0.125 0.629866180048662 0.856083119710275 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/3699 16/18639 0.125 0.629866180048662 0.856083119710275 1 GO:0043021 ribonucleoprotein complex binding 30/3699 177/18639 0.169491525423729 0.854055837354118 0.857401400696936 1 GO:0003887 DNA-directed DNA polymerase activity 3/3699 23/18639 0.130434782608696 0.657251666137734 0.86314371734758 1 GO:0099186 structural constituent of postsynapse 3/3699 23/18639 0.130434782608696 0.657251666137734 0.86314371734758 1 GO:0055106 ubiquitin-protein transferase regulator activity 5/3699 36/18639 0.138888888888889 0.69985131116518 0.868662587538522 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 4/3699 30/18639 0.133333333333333 0.671857258718572 0.873339509704439 1 GO:0015215 nucleotide transmembrane transporter activity 4/3699 30/18639 0.133333333333333 0.671857258718572 0.873339509704439 1 GO:0022839 monoatomic ion-gated channel activity 4/3699 30/18639 0.133333333333333 0.671857258718572 0.873339509704439 1 GO:0048019 receptor antagonist activity 4/3699 30/18639 0.133333333333333 0.671857258718572 0.873339509704439 1 GO:0015293 symporter activity 24/3699 146/18639 0.164383561643836 0.828317168283172 0.874511737408338 1 GO:0004549 tRNA-specific ribonuclease activity 2/3699 17/18639 0.117647058823529 0.592815228281093 0.878905574771494 1 GO:0004659 prenyltransferase activity 2/3699 17/18639 0.117647058823529 0.592815228281093 0.878905574771494 1 GO:0009881 photoreceptor activity 2/3699 17/18639 0.117647058823529 0.592815228281093 0.878905574771494 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/3699 17/18639 0.117647058823529 0.592815228281093 0.878905574771494 1 GO:0030548 acetylcholine receptor regulator activity 2/3699 17/18639 0.117647058823529 0.592815228281093 0.878905574771494 1 GO:0032183 SUMO binding 2/3699 17/18639 0.117647058823529 0.592815228281093 0.878905574771494 1 GO:0048038 quinone binding 2/3699 17/18639 0.117647058823529 0.592815228281093 0.878905574771494 1 GO:0070402 NADPH binding 2/3699 17/18639 0.117647058823529 0.592815228281093 0.878905574771494 1 GO:0004806 triacylglycerol lipase activity 3/3699 24/18639 0.125 0.629866180048662 0.882135573491917 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/3699 24/18639 0.125 0.629866180048662 0.882135573491917 1 GO:0140612 DNA damage sensor activity 3/3699 24/18639 0.125 0.629866180048662 0.882135573491917 1 GO:0015085 calcium ion transmembrane transporter activity 24/3699 147/18639 0.163265306122449 0.822682357614579 0.882448380260466 1 GO:0030551 cyclic nucleotide binding 5/3699 37/18639 0.135135135135135 0.680936410863418 0.883941115839375 1 GO:0016779 nucleotidyltransferase activity 22/3699 136/18639 0.161764705882353 0.815120938886503 0.88396015074876 1 GO:0005262 calcium channel activity 21/3699 131/18639 0.16030534351145 0.807767314871566 0.888885651214199 1 GO:0008514 organic anion transmembrane transporter activity 46/3699 269/18639 0.171003717472119 0.861675666386273 0.88918052270653 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/3699 31/18639 0.129032258064516 0.650184443921199 0.889377693093763 1 GO:0000182 rDNA binding 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0003796 lysozyme activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0004935 adrenergic receptor activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0005337 nucleoside transmembrane transporter activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0008401 retinoic acid 4-hydroxylase activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0015187 glycine transmembrane transporter activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0015203 polyamine transmembrane transporter activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0015643 toxic substance binding 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0016783 sulfurtransferase activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0032052 bile acid binding 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0032356 oxidized DNA binding 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0033204 ribonuclease P RNA binding 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0050308 sugar-phosphatase activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0051378 serotonin binding 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0140135 mechanosensitive monoatomic cation channel activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0140940 histone H2A methyltransferase activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0141109 transporter activator activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:1990259 histone H2AQ104 methyltransferase activity 1/3699 10/18639 0.1 0.503892944038929 0.890599277453231 1 GO:0140223 general transcription initiation factor activity 10/3699 68/18639 0.147058823529412 0.741019035351367 0.891707566496051 1 GO:0030547 signaling receptor inhibitor activity 6/3699 44/18639 0.136363636363636 0.687126741871267 0.89409843383376 1 GO:0000400 four-way junction DNA binding 2/3699 18/18639 0.111111111111111 0.559881048932144 0.898340340809003 1 GO:0015280 ligand-gated sodium channel activity 2/3699 18/18639 0.111111111111111 0.559881048932144 0.898340340809003 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/3699 18/18639 0.111111111111111 0.559881048932144 0.898340340809003 1 GO:0099602 neurotransmitter receptor regulator activity 2/3699 18/18639 0.111111111111111 0.559881048932144 0.898340340809003 1 GO:0015645 fatty acid ligase activity 3/3699 25/18639 0.12 0.604671532846715 0.898740335154351 1 GO:0015662 P-type ion transporter activity 3/3699 25/18639 0.12 0.604671532846715 0.898740335154351 1 GO:0120515 fatty acid-CoA ligase activity 3/3699 25/18639 0.12 0.604671532846715 0.898740335154351 1 GO:0140358 P-type transmembrane transporter activity 3/3699 25/18639 0.12 0.604671532846715 0.898740335154351 1 GO:0004386 helicase activity 25/3699 155/18639 0.161290322580645 0.812730554901499 0.899768279269871 1 GO:0004222 metalloendopeptidase activity 17/3699 110/18639 0.154545454545455 0.778743640787436 0.902548810539971 1 GO:0042910 xenobiotic transmembrane transporter activity 4/3699 32/18639 0.125 0.629866180048662 0.903608324111594 1 GO:0047498 calcium-dependent phospholipase A2 activity 4/3699 32/18639 0.125 0.629866180048662 0.903608324111594 1 GO:0019842 vitamin binding 24/3699 150/18639 0.16 0.806228710462287 0.903915952468904 1 GO:0015294 solute:monoatomic cation symporter activity 18/3699 116/18639 0.155172413793103 0.781902844198339 0.904508857773552 1 GO:0016782 transferase activity, transferring sulphur-containing groups 10/3699 70/18639 0.142857142857143 0.719847062912756 0.910953116296386 1 GO:0008046 axon guidance receptor activity 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0008503 benzodiazepine receptor activity 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0016594 glycine binding 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0019203 carbohydrate phosphatase activity 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0031731 CCR6 chemokine receptor binding 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0032404 mismatch repair complex binding 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0034056 estrogen response element binding 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0034511 U3 snoRNA binding 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0070990 snRNP binding 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:1990948 ubiquitin ligase inhibitor activity 1/3699 11/18639 0.0909090909090909 0.458084494580845 0.912322036200373 1 GO:0008143 poly(A) binding 3/3699 26/18639 0.115384615384615 0.581414935429534 0.913205244367157 1 GO:0120014 phospholipid transfer activity 3/3699 26/18639 0.115384615384615 0.581414935429534 0.913205244367157 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/3699 19/18639 0.105263157894737 0.530413625304136 0.914832789468133 1 GO:0016918 retinal binding 2/3699 19/18639 0.105263157894737 0.530413625304136 0.914832789468133 1 GO:0022840 leak channel activity 2/3699 19/18639 0.105263157894737 0.530413625304136 0.914832789468133 1 GO:0022842 narrow pore channel activity 2/3699 19/18639 0.105263157894737 0.530413625304136 0.914832789468133 1 GO:0042577 lipid phosphatase activity 2/3699 19/18639 0.105263157894737 0.530413625304136 0.914832789468133 1 GO:0043022 ribosome binding 17/3699 112/18639 0.151785714285714 0.764837504344804 0.916988896138306 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 29/3699 181/18639 0.160220994475138 0.807342286029224 0.920657833926992 1 GO:0015144 carbohydrate transmembrane transporter activity 5/3699 40/18639 0.125 0.629866180048662 0.920947239831923 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/3699 40/18639 0.125 0.629866180048662 0.920947239831923 1 GO:0036002 pre-mRNA binding 8/3699 59/18639 0.135593220338983 0.683244669883294 0.921293042730873 1 GO:0008146 sulfotransferase activity 7/3699 53/18639 0.132075471698113 0.665518982692926 0.923289966097419 1 GO:0016860 intramolecular oxidoreductase activity 7/3699 53/18639 0.132075471698113 0.665518982692926 0.923289966097419 1 GO:0015103 inorganic anion transmembrane transporter activity 26/3699 165/18639 0.157575757575758 0.794013123940131 0.925547055260971 1 GO:0005104 fibroblast growth factor receptor binding 3/3699 27/18639 0.111111111111111 0.559881048932144 0.925763893606293 1 GO:0016405 CoA-ligase activity 3/3699 27/18639 0.111111111111111 0.559881048932144 0.925763893606293 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/3699 34/18639 0.117647058823529 0.592815228281093 0.927286661265266 1 GO:0016831 carboxy-lyase activity 4/3699 34/18639 0.117647058823529 0.592815228281093 0.927286661265266 1 GO:0010851 cyclase regulator activity 2/3699 20/18639 0.1 0.503892944038929 0.928784989657486 1 GO:0003720 telomerase activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0004126 cytidine deaminase activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0004300 enoyl-CoA hydratase activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0004526 ribonuclease P activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0010853 cyclase activator activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0015166 polyol transmembrane transporter activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0015269 calcium-activated potassium channel activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0016423 tRNA (guanine) methyltransferase activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0031543 peptidyl-proline dioxygenase activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0036009 protein-glutamine N-methyltransferase activity 1/3699 12/18639 0.0833333333333333 0.419910786699108 0.92973242851811 1 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/3699 41/18639 0.121951219512195 0.614503590291377 0.930724840619466 1 GO:0004521 RNA endonuclease activity 10/3699 73/18639 0.136986301369863 0.690264306902643 0.934361766698559 1 GO:0036121 double-stranded DNA helicase activity 6/3699 48/18639 0.125 0.629866180048662 0.934949347811737 1 GO:0042054 histone methyltransferase activity 9/3699 67/18639 0.134328358208955 0.676871118858263 0.935442761100482 1 GO:0051119 sugar transmembrane transporter activity 3/3699 28/18639 0.107142857142857 0.539885297184567 0.93663380533072 1 GO:0034061 DNA polymerase activity 4/3699 35/18639 0.114285714285714 0.575877650330205 0.937037619739579 1 GO:0043015 gamma-tubulin binding 4/3699 35/18639 0.114285714285714 0.575877650330205 0.937037619739579 1 GO:0016887 ATP hydrolysis activity 71/3699 417/18639 0.170263788968825 0.857947218867242 0.938116659784066 1 GO:0016859 cis-trans isomerase activity 5/3699 42/18639 0.119047619047619 0.599872552427297 0.93940746538243 1 GO:0005248 voltage-gated sodium channel activity 2/3699 21/18639 0.0952380952380952 0.479898041941838 0.940555350507072 1 GO:0009975 cyclase activity 2/3699 21/18639 0.0952380952380952 0.479898041941838 0.940555350507072 1 GO:0002161 aminoacyl-tRNA editing activity 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0003964 RNA-directed DNA polymerase activity 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0008253 5'-nucleotidase activity 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0009982 pseudouridine synthase activity 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0039706 co-receptor binding 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0046975 histone H3K36 methyltransferase activity 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0051011 microtubule minus-end binding 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0140333 glycerophospholipid flippase activity 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:1901338 catecholamine binding 1/3699 13/18639 0.0769230769230769 0.387609956953023 0.943686352763105 1 GO:0106222 lncRNA binding 3/3699 29/18639 0.103448275862069 0.521268562798893 0.946015131788512 1 GO:0005245 voltage-gated calcium channel activity 5/3699 43/18639 0.116279069767442 0.585922027952243 0.947097840722231 1 GO:0004252 serine-type endopeptidase activity 27/3699 176/18639 0.153409090909091 0.773017584605176 0.948922288012449 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/3699 22/18639 0.0909090909090909 0.458084494580845 0.950460111058609 1 GO:0051536 iron-sulfur cluster binding 10/3699 76/18639 0.131578947368421 0.66301703163017 0.952242958534939 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/3699 44/18639 0.113636363636364 0.572605618226056 0.953892636477164 1 GO:0070566 adenylyltransferase activity 3/3699 30/18639 0.1 0.503892944038929 0.954090200908965 1 GO:0098918 structural constituent of synapse 3/3699 30/18639 0.1 0.503892944038929 0.954090200908965 1 GO:0005344 oxygen carrier activity 1/3699 14/18639 0.0714285714285714 0.359923531456378 0.954869869413447 1 GO:0005347 ATP transmembrane transporter activity 1/3699 14/18639 0.0714285714285714 0.359923531456378 0.954869869413447 1 GO:0008174 mRNA methyltransferase activity 1/3699 14/18639 0.0714285714285714 0.359923531456378 0.954869869413447 1 GO:0008559 ABC-type xenobiotic transporter activity 1/3699 14/18639 0.0714285714285714 0.359923531456378 0.954869869413447 1 GO:0061783 peptidoglycan muralytic activity 1/3699 14/18639 0.0714285714285714 0.359923531456378 0.954869869413447 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/3699 14/18639 0.0714285714285714 0.359923531456378 0.954869869413447 1 GO:1990825 sequence-specific mRNA binding 1/3699 14/18639 0.0714285714285714 0.359923531456378 0.954869869413447 1 GO:0016830 carbon-carbon lyase activity 6/3699 51/18639 0.117647058823529 0.592815228281093 0.955703628408919 1 GO:0022804 active transmembrane transporter activity 77/3699 457/18639 0.168490153172867 0.849009993238459 0.956228289337626 1 GO:0051540 metal cluster binding 10/3699 77/18639 0.12987012987013 0.654406420829778 0.957164717942785 1 GO:0005212 structural constituent of eye lens 2/3699 23/18639 0.0869565217391304 0.438167777425156 0.958775958078707 1 GO:0008171 O-methyltransferase activity 2/3699 23/18639 0.0869565217391304 0.438167777425156 0.958775958078707 1 GO:0051539 4 iron, 4 sulfur cluster binding 5/3699 45/18639 0.111111111111111 0.559881048932144 0.959882105511779 1 GO:0016878 acid-thiol ligase activity 3/3699 31/18639 0.0967741935483871 0.487638332940899 0.961023683889165 1 GO:0008020 G protein-coupled photoreceptor activity 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0008242 omega peptidase activity 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0008252 nucleotidase activity 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0015250 water channel activity 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0016846 carbon-sulfur lyase activity 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0034483 heparan sulfate sulfotransferase activity 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/3699 15/18639 0.0666666666666667 0.335928629359286 0.963832895080006 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/3699 46/18639 0.108695652173913 0.547709721781445 0.965149919398385 1 GO:0000217 DNA secondary structure binding 4/3699 39/18639 0.102564102564103 0.516813275937363 0.965241756027529 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/3699 39/18639 0.102564102564103 0.516813275937363 0.965241756027529 1 GO:0015370 solute:sodium symporter activity 10/3699 79/18639 0.126582278481013 0.637839169669531 0.965675008545657 1 GO:0005540 hyaluronic acid binding 2/3699 24/18639 0.0833333333333333 0.419910786699108 0.965743265768415 1 GO:0048027 mRNA 5'-UTR binding 2/3699 24/18639 0.0833333333333333 0.419910786699108 0.965743265768415 1 GO:0015106 bicarbonate transmembrane transporter activity 3/3699 32/18639 0.09375 0.472399635036496 0.966963203866155 1 GO:0022884 macromolecule transmembrane transporter activity 3/3699 32/18639 0.09375 0.472399635036496 0.966963203866155 1 GO:0061749 forked DNA-dependent helicase activity 5/3699 47/18639 0.106382978723404 0.53605632344567 0.969773161271851 1 GO:0099095 ligand-gated monoatomic anion channel activity 5/3699 47/18639 0.106382978723404 0.53605632344567 0.969773161271851 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 5/3699 47/18639 0.106382978723404 0.53605632344567 0.969773161271851 1 GO:0017069 snRNA binding 6/3699 54/18639 0.111111111111111 0.559881048932144 0.970267097189248 1 GO:0015562 efflux transmembrane transporter activity 1/3699 16/18639 0.0625 0.314933090024331 0.971016213437988 1 GO:0019841 retinol binding 1/3699 16/18639 0.0625 0.314933090024331 0.971016213437988 1 GO:0022841 potassium ion leak channel activity 1/3699 16/18639 0.0625 0.314933090024331 0.971016213437988 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/3699 16/18639 0.0625 0.314933090024331 0.971016213437988 1 GO:0000030 mannosyltransferase activity 2/3699 25/18639 0.08 0.403114355231144 0.971569607560942 1 GO:0009378 four-way junction helicase activity 5/3699 48/18639 0.104166666666667 0.524888483373885 0.973822441906748 1 GO:0043138 3'-5' DNA helicase activity 5/3699 48/18639 0.104166666666667 0.524888483373885 0.973822441906748 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 11/3699 88/18639 0.125 0.629866180048662 0.974452646804635 1 GO:0016279 protein-lysine N-methyltransferase activity 8/3699 69/18639 0.115942028985507 0.584223703233541 0.975801185879945 1 GO:0003823 antigen binding 25/3699 174/18639 0.14367816091954 0.723984114998462 0.975893635361484 1 GO:0008276 protein methyltransferase activity 12/3699 95/18639 0.126315789473684 0.636496350364964 0.976219890911765 1 GO:0015035 protein-disulfide reductase activity 3/3699 34/18639 0.0882352941176471 0.44461142121082 0.976371234429389 1 GO:0019825 oxygen binding 3/3699 34/18639 0.0882352941176471 0.44461142121082 0.976371234429389 1 GO:0015145 monosaccharide transmembrane transporter activity 2/3699 26/18639 0.0769230769230769 0.387609956953023 0.976433304493758 1 GO:0005132 type I interferon receptor binding 1/3699 17/18639 0.0588235294117647 0.296407614140547 0.976773128354644 1 GO:0008569 minus-end-directed microtubule motor activity 1/3699 17/18639 0.0588235294117647 0.296407614140547 0.976773128354644 1 GO:0016018 cyclosporin A binding 1/3699 17/18639 0.0588235294117647 0.296407614140547 0.976773128354644 1 GO:0008094 ATP-dependent activity, acting on DNA 31/3699 210/18639 0.147619047619048 0.743841965009848 0.977265320170055 1 GO:0031492 nucleosomal DNA binding 4/3699 42/18639 0.0952380952380952 0.479898041941838 0.978113259751656 1 GO:0016278 lysine N-methyltransferase activity 8/3699 70/18639 0.114285714285714 0.575877650330205 0.978657555000469 1 GO:0008320 protein transmembrane transporter activity 2/3699 27/18639 0.0740740740740741 0.373254032621429 0.980486857364755 1 GO:0008395 steroid hydroxylase activity 2/3699 27/18639 0.0740740740740741 0.373254032621429 0.980486857364755 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/3699 43/18639 0.0930232558139535 0.468737622361795 0.981294328370058 1 GO:0003746 translation elongation factor activity 1/3699 18/18639 0.0555555555555556 0.279940524466072 0.981386821739682 1 GO:0005372 water transmembrane transporter activity 1/3699 18/18639 0.0555555555555556 0.279940524466072 0.981386821739682 1 GO:0022851 GABA-gated chloride ion channel activity 1/3699 18/18639 0.0555555555555556 0.279940524466072 0.981386821739682 1 GO:0015399 primary active transmembrane transporter activity 23/3699 166/18639 0.13855421686747 0.698164922463577 0.982795211725877 1 GO:0005272 sodium channel activity 5/3699 51/18639 0.0980392156862745 0.494012690234245 0.983140410182593 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/3699 36/18639 0.0833333333333333 0.419910786699108 0.983192784628545 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/3699 36/18639 0.0833333333333333 0.419910786699108 0.983192784628545 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/3699 36/18639 0.0833333333333333 0.419910786699108 0.983192784628545 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/3699 36/18639 0.0833333333333333 0.419910786699108 0.983192784628545 1 GO:0005242 inward rectifier potassium channel activity 2/3699 28/18639 0.0714285714285714 0.359923531456378 0.983860169059681 1 GO:0022853 active monoatomic ion transmembrane transporter activity 15/3699 118/18639 0.127118644067797 0.640541878015588 0.984588478807736 1 GO:0004890 GABA-A receptor activity 1/3699 19/18639 0.0526315789473684 0.265206812652068 0.98508426797699 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/3699 20/18639 0.05 0.251946472019465 0.988047387888543 1 GO:0015464 acetylcholine receptor activity 1/3699 20/18639 0.05 0.251946472019465 0.988047387888543 1 GO:0140939 histone H4 methyltransferase activity 1/3699 20/18639 0.05 0.251946472019465 0.988047387888543 1 GO:0140097 catalytic activity, acting on DNA 51/3699 336/18639 0.151785714285714 0.764837504344804 0.989125345561285 1 GO:0051428 peptide hormone receptor binding 1/3699 21/18639 0.0476190476190476 0.239949020970919 0.990421989757616 1 GO:0070182 DNA polymerase binding 1/3699 21/18639 0.0476190476190476 0.239949020970919 0.990421989757616 1 GO:1904047 S-adenosyl-L-methionine binding 1/3699 21/18639 0.0476190476190476 0.239949020970919 0.990421989757616 1 GO:0005506 iron ion binding 20/3699 154/18639 0.12987012987013 0.654406420829778 0.990476437299799 1 GO:0005452 solute:inorganic anion antiporter activity 2/3699 31/18639 0.0645161290322581 0.3250922219606 0.990918892905078 1 GO:0016853 isomerase activity 24/3699 180/18639 0.133333333333333 0.671857258718572 0.991614061905673 1 GO:0008170 N-methyltransferase activity 11/3699 98/18639 0.112244897959184 0.565594120860023 0.992067022596751 1 GO:0016881 acid-amino acid ligase activity 1/3699 22/18639 0.0454545454545455 0.229042247290422 0.992324936362331 1 GO:0034062 5'-3' RNA polymerase activity 1/3699 22/18639 0.0454545454545455 0.229042247290422 0.992324936362331 1 GO:0097747 RNA polymerase activity 1/3699 22/18639 0.0454545454545455 0.229042247290422 0.992324936362331 1 GO:0030515 snoRNA binding 2/3699 32/18639 0.0625 0.314933090024331 0.992515938841006 1 GO:0005179 hormone activity 16/3699 132/18639 0.121212121212121 0.610779326107793 0.993185026253004 1 GO:0042923 neuropeptide binding 2/3699 33/18639 0.0606060606060606 0.305389663053897 0.99383695149658 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/3699 23/18639 0.0434782608695652 0.219083888712578 0.993849889920678 1 GO:0016917 GABA receptor activity 1/3699 23/18639 0.0434782608695652 0.219083888712578 0.993849889920678 1 GO:0140102 catalytic activity, acting on a rRNA 1/3699 23/18639 0.0434782608695652 0.219083888712578 0.993849889920678 1 GO:0017116 single-stranded DNA helicase activity 5/3699 58/18639 0.0862068965517241 0.434390468999077 0.994219858151459 1 GO:0015078 proton transmembrane transporter activity 24/3699 185/18639 0.12972972972973 0.653698954428881 0.994773649237475 1 GO:0008175 tRNA methyltransferase activity 2/3699 34/18639 0.0588235294117647 0.296407614140547 0.994928558813279 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/3699 34/18639 0.0588235294117647 0.296407614140547 0.994928558813279 1 GO:0005315 phosphate transmembrane transporter activity 1/3699 24/18639 0.0416666666666667 0.209955393349554 0.995071917057732 1 GO:0015149 hexose transmembrane transporter activity 1/3699 24/18639 0.0416666666666667 0.209955393349554 0.995071917057732 1 GO:0055056 D-glucose transmembrane transporter activity 1/3699 24/18639 0.0416666666666667 0.209955393349554 0.995071917057732 1 GO:0003678 DNA helicase activity 7/3699 74/18639 0.0945945945945946 0.476655487604393 0.995153971483813 1 GO:0015271 outward rectifier potassium channel activity 1/3699 25/18639 0.04 0.201557177615572 0.996051179953432 1 GO:0017056 structural constituent of nuclear pore 1/3699 25/18639 0.04 0.201557177615572 0.996051179953432 1 GO:0016836 hydro-lyase activity 5/3699 61/18639 0.0819672131147541 0.413027003310598 0.9964058820304 1 GO:0015081 sodium ion transmembrane transporter activity 20/3699 164/18639 0.121951219512195 0.614503590291377 0.996563522242694 1 GO:0046906 tetrapyrrole binding 18/3699 152/18639 0.118421052631579 0.596715328467153 0.996867635536386 1 GO:0030280 structural constituent of skin epidermis 2/3699 37/18639 0.0540540540540541 0.272374564345367 0.997185752098452 1 GO:0015252 proton channel activity 1/3699 27/18639 0.037037037037037 0.186627016310715 0.997464704110552 1 GO:0020037 heme binding 16/3699 142/18639 0.112676056338028 0.567766697508653 0.997795172257996 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/3699 48/18639 0.0625 0.314933090024331 0.998012129359725 1 GO:0009055 electron transfer activity 12/3699 116/18639 0.103448275862069 0.521268562798893 0.99805431099066 1 GO:0019843 rRNA binding 5/3699 65/18639 0.0769230769230769 0.387609956953023 0.998117574830024 1 GO:0071855 neuropeptide receptor binding 2/3699 40/18639 0.05 0.251946472019465 0.998446846699196 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 5/3699 68/18639 0.0735294117647059 0.370509517675683 0.99885146937025 1 GO:0005184 neuropeptide hormone activity 1/3699 31/18639 0.032258064516129 0.1625461109803 0.998955082947196 1 GO:0099094 ligand-gated monoatomic cation channel activity 14/3699 136/18639 0.102941176470588 0.518713324745957 0.999118005538387 1 GO:0160041 neuropeptide activity 1/3699 32/18639 0.03125 0.157466545012165 0.999162797273202 1 GO:0016835 carbon-oxygen lyase activity 6/3699 79/18639 0.0759493670886076 0.382703501801719 0.999293050453175 1 GO:0000049 tRNA binding 6/3699 80/18639 0.075 0.377919708029197 0.999398458641111 1 GO:0016829 lyase activity 23/3699 200/18639 0.115 0.579476885644769 0.999430899022118 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/3699 46/18639 0.0434782608695652 0.219083888712578 0.999533392249473 1 GO:0008173 RNA methyltransferase activity 4/3699 67/18639 0.0597014925373134 0.30083160838145 0.999683788446469 1 GO:0008188 neuropeptide receptor activity 2/3699 48/18639 0.0416666666666667 0.209955393349554 0.999688578842321 1 GO:0046873 metal ion transmembrane transporter activity 62/3699 450/18639 0.137777777777778 0.694252500675858 0.999733606866764 1 GO:0001653 peptide receptor activity 11/3699 128/18639 0.0859375 0.433032998783455 0.999859512951033 1 GO:0015276 ligand-gated monoatomic ion channel activity 19/3699 186/18639 0.102150537634409 0.514729351437616 0.999874697383141 1 GO:0004497 monooxygenase activity 8/3699 106/18639 0.0754716981132075 0.380296561538815 0.999879694492309 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/3699 41/18639 0.024390243902439 0.122900718058275 0.99988615621785 1 GO:0008227 G protein-coupled amine receptor activity 1/3699 41/18639 0.024390243902439 0.122900718058275 0.99988615621785 1 GO:0008528 G protein-coupled peptide receptor activity 10/3699 122/18639 0.0819672131147541 0.413027003310598 0.999888093837321 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/3699 73/18639 0.0547945205479452 0.276105722761057 0.99989336617306 1 GO:0022834 ligand-gated channel activity 19/3699 188/18639 0.101063829787234 0.509253507273386 0.999902495341951 1 GO:0140098 catalytic activity, acting on RNA 49/3699 387/18639 0.126614987080103 0.638003985992443 0.99993667267613 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/3699 56/18639 0.0357142857142857 0.179961765728189 0.999939085002404 1 GO:0003954 NADH dehydrogenase activity 1/3699 44/18639 0.0227272727272727 0.114521123645211 0.999941471883067 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/3699 58/18639 0.0344827586206897 0.173756187599631 0.999959615427812 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 15/3699 167/18639 0.0898203592814371 0.452598452729577 0.99996336100569 1 GO:0022824 transmitter-gated monoatomic ion channel activity 2/3699 63/18639 0.0317460317460317 0.159966013980612 0.999985614450464 1 GO:0022835 transmitter-gated channel activity 2/3699 63/18639 0.0317460317460317 0.159966013980612 0.999985614450464 1 GO:0008168 methyltransferase activity 19/3699 204/18639 0.0931372549019608 0.469312055722532 0.999987796595626 1 GO:0003730 mRNA 3'-UTR binding 27/3699 262/18639 0.103053435114504 0.519278988131721 0.999990622107654 1 GO:0140101 catalytic activity, acting on a tRNA 10/3699 139/18639 0.0719424460431655 0.362512909380525 0.999991854156808 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/3699 53/18639 0.0188679245283019 0.0950741403847037 0.999992052747338 1 GO:0030594 neurotransmitter receptor activity 5/3699 97/18639 0.0515463917525773 0.259738630947902 0.999992819182846 1 GO:0098960 postsynaptic neurotransmitter receptor activity 2/3699 69/18639 0.0289855072463768 0.146055925808385 0.999995863624214 1 GO:0022832 voltage-gated channel activity 14/3699 175/18639 0.08 0.403114355231144 0.999996026186257 1 GO:0015079 potassium ion transmembrane transporter activity 12/3699 160/18639 0.075 0.377919708029197 0.999996328055198 1 GO:0005216 monoatomic ion channel activity 54/3699 448/18639 0.120535714285714 0.607370959332638 0.999996446715911 1 GO:0016741 transferase activity, transferring one-carbon groups 19/3699 215/18639 0.0883720930232558 0.445300741243705 0.99999726658605 1 GO:0005244 voltage-gated monoatomic ion channel activity 13/3699 173/18639 0.0751445086705202 0.378647877023473 0.999998332632317 1 GO:0022843 voltage-gated monoatomic cation channel activity 9/3699 143/18639 0.0629370629370629 0.3171354193252 0.999998892703516 1 GO:0005249 voltage-gated potassium channel activity 4/3699 98/18639 0.0408163265306122 0.205670589403645 0.99999903556929 1 GO:0005267 potassium channel activity 6/3699 124/18639 0.0483870967741935 0.24381916647045 0.999999713834683 1 GO:0022836 gated channel activity 31/3699 318/18639 0.0974842767295598 0.491216391987636 0.999999722817488 1 GO:0005261 monoatomic cation channel activity 33/3699 341/18639 0.0967741935483871 0.487638332940899 0.999999911658848 1 GO:0016874 ligase activity 10/3699 167/18639 0.0598802395209581 0.301732301819718 0.999999917862091 1 GO:0003735 structural constituent of ribosome 3/3699 175/18639 0.0171428571428571 0.0863816475495308 0.999999999999987 1 GO:0045182 translation regulator activity 21/3699 356/18639 0.0589887640449438 0.297240219798245 0.99999999999999 1 GO:0030371 translation repressor activity 14/3699 329/18639 0.0425531914893617 0.214422529378268 1 1 GO:1903231 mRNA base-pairing translational repressor activity 2/3699 298/18639 0.00671140939597315 0.0338183183918745 1 1