category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	31/564	109/9376	4.72795887826144	HLA-DRA/NFKBIA/FOS/HLA-DPA1/HLA-DRB1/EBI3/HLA-DPB1/JUN/HSP90AA1/IL6ST/IL1B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/IL4R/RXRA/MAPK8/IL1RAP/HLA-DQA2/AHR/TGFBR1/CD4/HLA-DRB5/RUNX1/IL2RB/IL27RA/JAK2/SMAD3/RXRB/SMAD4	9.9038197274425
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	29/564	112/9376	4.30445795339412	HLA-DRA/NFKBIA/HLA-DPA1/HLA-DRB1/HSPA1B/HLA-DPB1/HSPA1A/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/LAMA5/HSPA6/LY96/MAPK8/LDLR/PPIF/BIRC7/LAMA3/SOCS1/AKT3/HLA-DQA2/ITGA6/MAP2K3/TGFB2/HLA-DRB5/PDPK1/BCL2/JAK2	8.9001620527906
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	23/564	78/9376	4.90198217857792	HLA-DRA/NFKBIA/FOS/HLA-DPA1/HLA-DRB1/HLA-DPB1/JUN/IL1B/HLA-DQB1/ITGB2/HLA-DQA1/HLA-DMA/FCGR3A/HLA-DMB/NCF2/HLA-DQA2/FCGR1A/TGFB2/FCGR2A/HLA-DRB5/PTGS2/JAK2/CYBB	8.75438733451022
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	25/564	95/9376	4.37476670399403	HLA-DRA/FOS/HLA-DPA1/HLA-DRB1/HLA-DPB1/JUN/CXCL2/CCL3/IL1B/CXCL3/HLA-DQB1/CCL5/ITGB2/HLA-DQA1/HLA-DMA/CCL20/HLA-DMB/CCL2/FLT1/HLA-DQA2/TGFB2/ATP6V0A1/HLA-DRB5/ATP6V0D1/TNFSF13B	8.36365515383683
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	23/564	82/9376	4.66286109669607	HLA-DRA/HLA-B/CD74/HLA-DPA1/HLA-DRB1/HSPA1B/HLA-A/HLA-DPB1/CTSS/HSP90AA1/HSPA1A/HLA-DQB1/HLA-DQA1/HLA-DMA/TAPBP/CTSB/TAPBPL/HLA-DMB/HSPA6/HLA-F/HLA-DQA2/CD4/HLA-DRB5	8.42779547609885
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	38/564	216/9376	2.92461255581823	NFKBIA/FOS/HSPA1B/TNFSF10/JUN/ABCA1/CXCL2/HSP90AA1/CCL3/HSPA1A/IL1B/CXCL3/MMP9/CCL5/ABCG1/CD36/OLR1/CAMK2G/HSPA6/RXRA/LY96/MAPK8/CCL2/LDLR/VAV3/PIK3R1/VLDLR/PTK2/AKT3/NCF2/SOD2/MAP2K3/CD14/PDPK1/BCL2/JAK2/CYBB/RXRB	7.23953045485486
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	34/564	181/9376	3.12276164727087	HLA-DRA/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/FCER1G/CTSS/PLK3/IL1B/HLA-DQB1/MRC2/ITGB2/HLA-DQA1/HLA-DMA/LSP1/FCGR3A/HLA-DMB/CAMK2G/CTSD/MAPK8/KSR1/AKT3/HLA-DQA2/FCGR1A/CD14/TGFB2/FCGR2A/ATP6V0A1/HLA-DRB5/ATP6V0D1/BCL2/JAK2/ITGAX/CREBBP	7.29545862995987
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	31/564	155/9376	3.32482269503546	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/CTSS/HLA-DQB1/MRC2/ITGB2/SCARB1/HLA-DQA1/HLA-DMA/FCGR3A/MSR1/CD36/HLA-DMB/OLR1/DYNC1LI2/THBS3/HLA-F/TUBB2A/NCF2/HLA-DQA2/FCGR1A/CD14/FCGR2A/ATP6V0A1/HLA-DRB5/ATP6V0D1/CYBB	7.38336979605784
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	38/564	224/9376	2.82016210739615	HLA-DRA/HLA-B/CREB5/NFKBIA/FOS/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/JUN/EGR1/CDKN1A/ADCY7/HLA-DQB1/ITGB2/HLA-DQA1/HLA-DMA/HLA-DMB/MAPK8/ETS2/SPI1/PIK3R1/NFKB2/HLA-F/AKT3/ZFP36/HLA-DQA2/MMP7/TGFBR1/CD4/TGFB2/ATM/HLA-DRB5/IL2RB/SMAD3/CREBBP/CDKN2A/SMAD4	6.97531810727354
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	23/564	99/9376	3.86216777706139	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/C1QB/KRT15/C1QA/HLA-DQB1/ITGB2/HLA-DQA1/HLA-DMA/FCGR3A/HLA-DMB/C1QC/C5AR1/KRT13/HLA-DQA2/FCGR1A/KRT14/FCGR2A/HLA-DRB5/FPR3/C2	7.24263923489623
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	26/564	133/9376	3.24982669439556	TNFSF10/GADD45B/CDKN1A/FBXO32/PRKAG2/PLK3/IRS2/HOMER3/HOMER1/MAPK8/GABARAPL1/FOXO1/EGFR/BCL6/PIK3R1/AKT3/SOD2/TGFBR1/TGFB2/ATM/RBL2/PDPK1/SMAD3/CREBBP/MDM2/SMAD4	6.61083557239973
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	19/564	76/9376	4.15602836879433	ANGPTL4/ACOX1/CD36/SLC27A1/OLR1/LPL/RXRA/FABP7/ACSL5/CPT1A/FABP4/CYP27A1/ACSL3/PLIN5/FADS2/PDPK1/HMGCS1/UBC/RXRB	6.98866408229673
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/564	44/9376	5.28949065119278	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/IL1B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-F/HLA-DQA2/HLA-DRB5	7.21493868672301
Human Diseases	Immune disease	hsa05310	Asthma	12/564	32/9376	6.23404255319149	PRG2/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/FCER1G/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-DQA2/HLA-DRB5	7.50297966488518
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/564	45/9376	5.17194641449961	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/IL1B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-F/HLA-DQA2/HLA-DRB5	7.09690235240216
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/564	39/9376	5.54137115839243	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-F/HLA-DQA2/HLA-DRB5	7.18958077784162
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	30/564	180/9376	2.77068557919622	HLA-DRA/HLA-B/CD74/NFKBIA/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/IL1B/HLA-DQB1/CCL5/SRSF5/HLA-DQA1/HLA-DMA/TAPBP/TAPBPL/HLA-DMB/NXF1/CCL2/PIK3R1/HLA-F/AKT3/HLA-DQA2/BST2/TNFRSF14/HLA-DRB5/SRSF6/SRSF7/BCL2/JAK2	6.06828776773926
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/564	100/9376	3.49106382978723	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/IL1B/HLA-DQB1/CD22/HLA-DQA1/HLA-DMA/CD36/HLA-DMB/IL4R/CD37/CD44/HLA-DQA2/ITGA6/FCGR1A/CD14/CD4/HLA-DRB5/ITGA3	6.33566829763593
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	20/564	93/9376	3.5750781667048	HLA-DRA/NFKBIA/FOS/HLA-DPA1/HLA-DRB1/HLA-DPB1/JUN/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/IL4R/MAPK8/HLA-DQA2/CD4/HLA-DRB5/NOTCH2/IL2RB/JAK2/MAML2	6.31357961906632
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	23/564	119/9376	3.21306394898385	CREB5/NFKBIA/FOS/JUN/CXCL2/IL1B/CXCL3/MMP9/CCL5/JUNB/CCL20/DAB2IP/IRF1/BCL3/MAPK8/CCL2/CFLAR/PIK3R1/AKT3/RPS6KA5/MAP2K3/CXCL10/PTGS2	6.14639204825153
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	25/564	142/9376	2.92678054140445	FOSB/TYROBP/NFKBIA/FOS/JUND/JUN/SQSTM1/IL1B/TREM2/JUNB/FCGR3A/ITPR2/MAPK8/SPI1/PIK3R1/LILRB3/NFKB2/SOCS1/AKT3/NCF2/FCGR1A/TGFBR1/TGFB2/LILRB4/FCGR2A	5.8528775036696
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	40/564	298/9376	2.23142462754058	CSH1/CSH2/EBI3/TNFSF10/CXCL2/GDF15/IL6ST/CCL3/IL17RE/INHA/CCL4/IL1B/CXCL3/CCL5/CCL20/CXCR4/IL1RN/IL4R/TNFRSF25/CCL2/CCL18/CSF2RB/IL1RAP/CXCL16/TNFRSF12A/BMPR1B/OSMR/TGFBR1/CD4/TGFB2/CXCL10/TNFRSF14/OSM/RELT/IL2RB/TNFSF13B/IL27RA/CSHL1/PRLR/ACKR3	5.46523478278263
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/564	137/9376	2.91225345550551	NFKBIA/FOS/TNFSF10/JUN/GADD45B/CTSS/BCL2A1/ENDOG/CTSB/DAB2IP/CTSD/ITPR2/MAPK8/CSF2RB/CFLAR/PIK3R1/NOL3/CAPN2/AKT3/MCL1/ATM/PDPK1/CTSF/BCL2	5.7040221111916
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	30/564	205/9376	2.43279709392839	HLA-DRA/HLA-B/NFKBIA/VIM/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/JUN/GADD45B/CDKN1A/HLA-DQB1/HLA-DQA1/HLA-DMA/TAPBP/TAPBPL/HLA-DMB/MAPK8/ENTPD1/PIK3R1/NFKB2/CD44/HLA-F/AKT3/HLA-DQA2/MAP2K3/CXCL10/HLA-DRB5/BCL2/MDM2	5.24736436594763
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/564	66/9376	3.77820760799484	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/JUN/IL1B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/IL4R/HLA-DQA2/TGFB2/HLA-DRB5/SMAD3	5.72993597790749
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/564	101/9376	3.1273084755284	SERPINE1/FN1/JUN/EGR1/IL1B/PLCD3/MAPK8/CCL2/FOXO1/PIK3R1/PIM1/AKT3/TGFBR1/TGFB2/BCL2/JAK2/CYBB/SMAD3/SMAD4	5.4377863986819
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	25/564	160/9376	2.59751773049645	HLA-DRA/PTPRF/HLA-B/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/JAM2/HLA-DQB1/CD22/ESAM/ITGB2/HLA-DQA1/HLA-DMA/HLA-DMB/MAG/CD99L2/PTPRC/HLA-F/HLA-DQA2/ITGA6/CD4/PVR/HLA-DRB5/ALCAM	5.156112579342
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/564	94/9376	3.18334087822544	FOSB/NFKBIA/FOS/JUND/JUN/CXCL2/HSP90AA1/IL17RE/IL1B/CXCL3/MMP9/CCL20/S100A9/MAPK8/CCL2/S100A8/CXCL10/PTGS2	5.38211083151434
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/564	54/9376	4.00210139217231	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-F/HLA-DQA2/HLA-DRB5	5.59700419567447
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/564	87/9376	3.24838998940246	FOS/JUN/GADD45B/CDKN1A/TCF7/TCF7L2/MAPK8/EGFR/PIK3R1/EREG/RALGDS/AKT3/TGFBR1/TGFB2/BCL2/SMAD3/SMAD4	5.33009235092946
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	24/564	157/9376	2.54126575416723	SERPINE1/HLA-B/HLA-A/GADD45B/CDKN1A/SQSTM1/ZFP36L1/ITPR2/FOXO1/PIK3R1/CAPN2/HLA-F/AKT3/MAP2K3/TGFBR1/TGFB2/HIPK3/ATM/RBL2/ZFP36L2/SMAD3/MDM2/CDKN2A/HIPK2	4.92689598250226
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/564	50/9376	3.98978723404255	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/CXCR4/HLA-DMB/HLA-DQA2/HLA-DRB5/TNFSF13B	5.36247802811605
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/564	115/9376	2.74659266111625	CREB5/FOS/JUND/EGR1/CDKN1A/ADCY7/AKAP13/WNK2/PDE4C/RXRA/ITPR2/NR4A2/MAFB/EGFR/WNK1/HBEGF/PRKCG/BCL2/RXRB	4.76759718880734
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/564	70/9376	3.32482269503546	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-A/HLA-DPB1/HLA-DQB1/ITGB2/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-F/HLA-DQA2/HLA-DRB5	4.93907110434463
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	27/564	201/9376	2.23308986979994	HPGD/FUS/NFKBIZ/GADD45B/CDKN1A/MMP9/REL/ASPSCR1/BCL2A1/NR4A3/RXRA/DDX5/ARNT2/FLT1/FOXO1/BCL6/SPI1/PTK2/FCGR1A/CD14/ATM/RUNX1/IL2RB/AFF1/MDM2/RXRB/CEBPA	4.47072202937663
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	38/564	333/9376	1.89704598215237	SPP1/FN1/HLA-B/CREB5/HLA-A/CDKN1A/HES2/TCF7/LLGL2/TCF7L2/LAMA5/IRF1/WNT2B/FOXO1/EGFR/PIK3R1/LAMA3/ITGB6/THBS3/MX2/HLA-F/PTK2/AKT3/ITGA6/ATP6V0A1/ATM/ITGA3/HES4/RBL2/NOTCH2/ATP6V0D1/PTGS2/PTGER4/FZD8/CSNK1A1/CREBBP/MDM2/MAML2	4.21665920839701
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/564	56/9376	3.56231003039514	NFKBIA/HSPA1B/CXCL2/HSPA1A/IL1B/CXCL3/ITGB2/CLK4/HSPA6/NFKB2/CLK1/CD14	4.86525581004766
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/564	122/9376	2.58900127892106	CSH1/CREB5/CSH2/FOS/ADCY7/IRS2/JUNB/ITPR2/MAPK8/PIK3R1/SOCS1/PTK2/AKT3/MAP2K3/CACNA1C/PRKCG/JAK2/CSHL1/CREBBP	4.46917499741053
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	35/564	300/9376	1.93947990543735	IGF2/FOS/DUSP1/HSPA1B/RASGRF2/JUND/JUN/GADD45B/HSPB1/MAPK8IP3/HSPA1A/IL1B/PDGFB/DUSP2/HSPA6/MAPK8/RASA1/FLT1/EGFR/IL1RAP/NFKB2/EREG/AKT3/RPS6KA5/MAP3K2/MAP2K3/CD14/CACNA1A/TGFBR1/TGFB2/RASGRF1/MAPK8IP2/CACNA1C/PRKCG/MAP3K9	4.18397253587176
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/564	93/9376	2.86006253336384	FN1/NFKBIA/GADD45B/CDKN1A/LAMA5/RXRA/BIRC7/PIK3R1/LAMA3/PTK2/AKT3/ITGA6/ITGA3/PTGS2/BCL2/RXRB	4.56050346458515
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	17/564	103/9376	2.74378571920402	SERPINE1/NFKBIA/FOS/JUN/CCL3/C1QB/C1QA/IL1B/CCL5/C1QC/MAPK8/CCL2/CFLAR/PIK3R1/AKT3/TGFBR1/TGFB2	4.50183470736144
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	21/564	144/9376	2.42434988179669	NFKBIA/CXCL2/TCF7/PRKAG2/C1QB/C1QA/IL1B/CXCL3/TCF7L2/ACOX1/C1QC/C5AR1/LY96/MAPK8/CPT1A/FOXO1/AKT3/TRA2A/MAP2K3/CD14/C2	4.35750584135368
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/564	178/9376	2.2414535022711	JUN/TLE6/TCF7/NOTUM/TCF7L2/CTNND2/TLE4/ANKRD6/CAMK2G/MAPK8/WNT2B/MMP7/SFRP1/BAMBI/PORCN/CELSR1/FZD8/PRKCG/CSNK1A1/SMAD3/CREBBP/TLE3/TBL1XR1/SMAD4	4.23040262060785
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/564	105/9376	2.69152313407633	NFKBIA/FCER1G/JUN/PLK3/IL1B/LSP1/IRF1/ITPR2/BCL3/MAPK8/PIK3R1/NFKB2/KSR1/AKT3/EGR3/PTGS2/MDM2	4.40958020929198
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/564	78/9376	2.98381523913439	FOS/JUN/C1QB/C1QA/IL1B/ITGB2/SERPING1/C1QC/IRF1/LY96/MAPK8/CD14/IRF8/C2	4.45083708962912
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/564	52/9376	3.51663938897981	APOE/APOC1/ABCA1/MYLIP/SCARB1/ANGPTL4/CD36/LPL/LDLR/CYP27A1/LCAT	4.60372607603576
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/564	139/9376	2.39195877340681	CREB5/FOS/HSPA1B/JUN/HSP90AA1/KRT15/HSPA1A/ADCY7/MMP9/HSPA6/CTSD/ITPR2/KRT13/EGFR/PIK3R1/NCOA3/AKT3/KRT14/HBEGF/BCL2	4.18269547899883
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	16/564	99/9376	2.68672541012967	FOS/JUN/CDKN1A/ADCY7/MMP9/MAPK8/EGFR/PIK3R1/NCOA3/PTK2/AKT3/HBEGF/NOTCH2/BCL2/MDM2/CDKN2A	4.26821367070387
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/564	173/9376	2.21014225392531	HLA-DRA/NFKBIA/HLA-DPA1/HLA-DRB1/HLA-DPB1/TNFSF10/IL1B/HLA-DQB1/CCL5/HLA-DQA1/HLA-DMA/DNAJB1/HLA-DMB/NXF1/CCL2/PIK3R1/MX2/AKT3/HLA-DQA2/CXCL10/HLA-DRB5/JAK2/CREBBP	4.0642714992501
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	22/564	168/9376	2.17696724079703	CSH1/CSH2/CDKN1A/IL6ST/PDGFB/IL4R/CSF2RB/EGFR/PIK3R1/SOCS1/PIM1/AKT3/OSMR/MCL1/OSM/IL2RB/BCL2/IL27RA/JAK2/CSHL1/PRLR/CREBBP	3.89425428592217
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/564	105/9376	2.53319824383654	NFKBIA/GADD45B/CXCL2/CCL4/IL1B/CXCL3/BCL2A1/LY96/CFLAR/NFKB2/CD14/ATM/PTGS2/PPP1R13L/TNFSF13B/BCL2	3.99684786849493
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	27/564	227/9376	1.97731746180523	HLA-B/CREB5/NFKBIA/HLA-A/CDKN1A/CCL3/CCL4/IL1B/ADCY7/CCL5/AKAP13/TAPBP/CXCR4/TAPBPL/PTGER3/ITPR2/CCL2/EGFR/PIK3R1/HLA-F/PTK2/AKT3/PTGS2/PTGER4/PRKCG/MDM2/CDKN2A	3.77094084075232
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	25/564	204/9376	2.03726880823251	TIMP3/FN1/IGF2/CDKN1A/HSPG2/MMP9/PPP1R12B/CAMK2G/ITPR2/DDX5/WNT2B/VAV3/EGFR/PIK3R1/CD44/PTK2/AKT3/PDCD4/HBEGF/TGFB2/TIAM1/PDPK1/FZD8/PRKCG/MDM2	3.78932910014414
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/564	106/9376	2.50930014719657	CREB5/NFKBIA/CDKN1A/HSP90AA1/TCF7/MMP9/TCF7L2/PDGFB/FOXO1/EGFR/PIK3R1/AKT3/PDPK1/BCL2/CREBBP/MDM2	3.95345341683265
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/564	88/9376	2.64474532559639	SERPINE1/SERPINE2/C1QB/C1QA/ITGB2/SERPING1/C1QC/CD46/C5AR1/SERPINA1/CLU/A2M/ITGAX/C2	3.92163201580257
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/564	70/9376	2.84984802431611	NFKBIA/PRKAG2/IRS2/CD36/RXRA/MAPK8/ACSL5/CPT1A/ACSL3/AKT3/JAK2/RXRB	3.92999042199618
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/564	100/9376	2.4936170212766	TNFSF10/CXCL2/IL6ST/CCL3/CCL4/CXCL3/CCL5/CCL20/CXCR4/CCL2/CCL18/CXCL10/TNFRSF14/IL2RB/ACKR3	3.79880350609876
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/564	71/9376	2.80970931974828	NFKBIA/JUN/CXCL2/CXCL3/JAM2/TJP1/CCL5/MAPK8/EGFR/HBEGF/ATP6V0A1/ATP6V0D1	3.87228892908853
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	24/564	203/9376	1.96541243056283	SPP1/FN1/JUN/PPP1R12B/PDGFB/LAMA5/FLNB/MAPK8/FLT1/VAV3/EGFR/PIK3R1/LAMA3/ITGB6/THBS3/CAPN2/PTK2/AKT3/ITGA6/ITGA3/RASGRF1/PDPK1/PRKCG/BCL2	3.51797828659918
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	23/564	196/9376	1.95078882616877	HLA-B/NFKBIA/FOS/HLA-A/JUN/CXCL2/CDKN1A/TCF7/IL6ST/CXCL3/TCF7L2/PDGFB/ITPR2/MAPK8/PIK3R1/HLA-F/AKT3/ZFP36/CLEC2B/PTGS2/UBC/JAK2/CREBBP	3.4031313375765
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/564	163/9376	2.03976852456163	CREB5/NFKBIA/FOS/JUN/CDKN1A/HSPG2/MMP9/MAPK8/PIK3R1/AKT3/MAP2K3/TGFBR1/TGFB2/EGR3/PRKCG/BCL2/JAK2/SMAD3/CREBBP/SMAD4	3.3878009002383
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	36/564	362/9376	1.65322675443752	SPP1/FN1/CSH1/IGF2/CREB5/CSH2/CDKN1A/HSP90AA1/PDGFB/IL4R/LAMA5/RXRA/FLT1/EGFR/PIK3R1/LAMA3/ITGB6/EREG/THBS3/PTK2/AKT3/ITGA6/OSMR/MCL1/PIK3AP1/ITGA3/RBL2/OSM/IL2RB/LPAR2/PDPK1/BCL2/JAK2/CSHL1/PRLR/MDM2	3.20661941931256
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/564	77/9376	2.59077093119646	GADD45B/CDKN1A/MAPK8/EGFR/PIK3R1/RALGDS/AKT3/TGFBR1/TGFB2/SMAD3/CDKN2A/SMAD4	3.5458701774834
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/564	77/9376	2.59077093119646	NFKBIA/GADD45B/CDKN1A/PIK3R1/AKT3/TGFBR1/TGFB2/RUNX1/SMAD3/MDM2/CDKN2A/SMAD4	3.5458701774834
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/564	142/9376	2.10728198981121	FOS/DUSP1/JUN/HSP90AA1/SQSTM1/IL1B/MMP9/PDGFB/MAPK8/HMOX1/CCL2/PIK3R1/BMPR1B/PTK2/AKT3/NCF2/GSTT1/BCL2	3.36353087916312
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/564	109/9376	2.28772203786844	SPP1/NFKBIA/FOS/JUN/CCL3/CCL4/IL1B/CCL5/LY96/MAPK8/PIK3R1/AKT3/MAP2K3/CD14/CXCL10	3.42100525745378
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/564	109/9376	2.28772203786844	PTPRF/CREB5/NFKBIA/MLXIP/PRKAG2/IRS2/CD36/SLC27A1/MAPK8/CPT1A/FOXO1/PIK3R1/AKT3/PDPK1/TBC1D4	3.42100525745378
NA	NA	hsa04518	Integrin signaling	19/564	154/9376	2.0510269871972	SPP1/FBN1/FN1/ITGB2/PDGFB/LAMA5/FLNB/FLT1/EGFR/PIK3R1/LAMA3/ITGB6/THBS3/PTK2/AKT3/ITGA6/FERMT3/ITGA3/ITGAX	3.32697559387359
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/564	68/9376	2.68919482686692	TCF7/TCF7L2/BCL2A1/SPI1/PIK3R1/PIM1/AKT3/FCGR1A/CD14/RUNX1/CEBPA	3.53666527047644
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	16/564	122/9376	2.18021160330194	MED13L/PLCD3/RXRA/FOXO1/PIK3R1/NCOA3/AKT3/NOTCH2/PDPK1/PRKCG/THRB/CREBBP/MDM2/ATP1B1/RXRB/TBC1D4	3.31942601878351
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/564	41/9376	3.24372945857118	CDKN1A/MMP9/DAPK1/EGFR/RPS6KA5/HBEGF/MDM2/CDKN2A	3.64244668053707
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	25/564	233/9376	1.78370316257267	FBN1/FBLN1/FN1/BGN/SYNE1/VIM/FMNL2/HSPG2/COL11A1/FBN2/CSRP2/SYNE2/ITGB6/SUN1/THBS3/ITGA6/MYOZ1/SYNE3/COL5A1/ITGA3/PDLIM3/AMPD3/ATP1B1/DIAPH2/FMNL1	3.06459540387678
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/564	62/9376	2.6813086250286	HSPA1B/PRKAG2/HSPA1A/ADCY7/IRS2/HSPA6/FOXO1/PIK3R1/AKT3/SOD2	3.36018442756215
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/564	143/9376	1.97629321033576	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/C1QB/C1QA/HLA-DQB1/HLA-DQA1/HLA-DMA/FCGR3A/HLA-DMB/C1QC/HLA-DQA2/FCGR1A/FCGR2A/HLA-DRB5/C2	2.97621852742888
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/564	110/9376	2.11579626047711	SERPINE1/CDKN1A/EPAS1/CAMK2G/HMOX1/PFKFB3/FLT1/EGFR/PIK3R1/AKT3/PRKCG/BCL2/CYBB/CREBBP	2.97798867721707
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/564	110/9376	2.11579626047711	FBN1/NOG/LTBP1/HAMP/BMPR1B/TGFBR1/BAMBI/TGFB2/EMP3/SMAD3/HFE/CREBBP/SKIL/SMAD4	2.97798867721707
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	31/564	323/9376	1.59550315086841	TIMP3/VIM/CDKN1A/MARCKS/FOXP1/MMP9/IRS2/PDGFB/MIR29A/HMOX1/EGFR/PIK3R1/SOCS1/CD44/PIM1/RPS6KA5/DNMT1/PDCD4/MCL1/TGFB2/ATM/NOTCH2/PTGS2/PRKCG/BCL2/CREBBP/RECK/MDM2/ZEB2/MDM4/CDKN2A	2.75535150644072
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	19/564	170/9376	1.85798915310805	IGF2/GADD45B/CDKN1A/TCF7/TCF7L2/HMOX1/WNT2B/EGFR/PIK3R1/AKT3/TGFBR1/GSTT1/TGFB2/FZD8/PRKCG/CSNK1A1/SMAD3/CDKN2A/SMAD4	2.85600339129388
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/564	91/9376	2.19219078793547	NFKBIA/FOS/JUN/CD22/INPPL1/VAV3/PIK3R1/LILRB3/AKT3/DAPP1/LILRB4/PIK3AP1	2.89110223729963
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/564	150/9376	1.88406619385343	GADD45B/CDKN1A/TCF7/TCF7L2/RXRA/WNT2B/EGFR/PIK3R1/AKT3/TGFBR1/TGFB2/FZD8/CSNK1A1/BCL2/SMAD3/RXRB/SMAD4	2.76128754558205
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/564	103/9376	2.09818907939131	FN1/CXCL2/HSPB1/IL1B/CXCL3/ITGB2/LAMA5/PIK3R1/LAMA3/PTK2/CD14/TGFB2/PRKCG	2.8351337314001
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/564	73/9376	2.27727581851744	GADD45B/CDKN1A/RXRA/EGFR/PIK3R1/AKT3/PDPK1/PRKCG/RXRB/CDKN2A	2.77154896504812
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/564	86/9376	2.12634009566221	JUN/CDKN1A/CAMK2G/MAPK8/EGFR/PIK3R1/EREG/PTK2/AKT3/HBEGF/PRKCG	2.65459858804365
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/564	75/9376	2.21654846335697	CDKN1A/PIK3R1/AKT3/GSTT1/ATM/PDPK1/BCL2/MDM2/ERCC1/CDKN2A	2.67598188993565
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/564	75/9376	2.21654846335697	SERPINE1/GADD45B/CDKN1A/ATM/PPP1R13L/SESN3/BCL2/MDM2/MDM4/CDKN2A	2.67598188993565
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/564	76/9376	2.18738335199701	GADD45B/CDKN1A/PDGFB/CAMK2G/EGFR/PIK3R1/AKT3/PRKCG/MDM2/CDKN2A	2.62932471268905
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	12/564	99/9376	2.01504405759725	FOS/JUN/PDGFB/MAPK8/DGKH/EGFR/PIK3R1/RALGDS/AKT3/PDPK1/PRKCG/LYPLA1	2.56854191973681
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/564	187/9376	1.68908104828005	NFKBIA/JUN/CXCL2/HSP90AA1/IL1B/CXCL3/CCL5/CTSB/TXNIP/ANTXR1/ITPR2/MAPK8/CCL2/GABARAPL1/GPSM3/NAMPT/IFI16/BCL2/CYBB	2.40793594156776
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/564	89/9376	2.05466571041517	SPP1/FN1/HSPG2/CD36/LAMA5/LAMA3/ITGB6/CD44/THBS3/ITGA6/ITGA3	2.5290653579138
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/564	138/9376	1.80696885599753	FN1/NFKBIA/FOS/JUN/BAIAP2/IL1B/MAPK8/CCL2/VAV3/PIK3R1/PTK2/AKT3/MAP2K3/CD4/FCGR2A	2.41599084444233
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/564	115/9376	1.87924761023743	CREB5/FOS/ADCY7/KCNJ2/CAMK2G/ITPR2/PIK3R1/AKT3/CACNA1A/CACNA1C/PRKCG/BCL2/JAK2	2.4000435408646
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	21/564	217/9376	1.60878517501716	KLF4/CREB5/FOS/JUN/HSP90AA1/ADCY7/RXRA/MIR29A/EGFR/BCL6/PIK3R1/AKT3/AHR/CACNA1A/GSTT1/NOTCH2/CACNA1C/PRKCG/BCL2/JAK2/RXRB	2.29539722056127
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/564	37/9376	2.69580218516389	GADD45B/CDKN1A/TCF7/TCF7L2/RXRA/RXRB	2.61465149842658
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	19/564	193/9376	1.63657075662367	NFKBIA/CXCL2/CCL3/CCL4/CXCL3/ADCY7/CCL5/CCL20/CXCR4/CCL2/CCL18/VAV3/PIK3R1/CXCL16/PTK2/AKT3/TIAM1/CXCL10/JAK2	2.26058578329925
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/564	93/9376	1.96629299168764	JUN/EGR1/ADCY7/CAMK2G/ITPR2/MAPK8/EGFR/MAP3K2/MAP2K3/HBEGF/CACNA1C	2.36915827148368
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/564	70/9376	2.13738601823708	JUN/CDKN1A/EPAS1/PDGFB/ARNT2/PIK3R1/AKT3/TGFB2/CREBBP	2.41636939847349
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/564	155/9376	1.7160375200183	CREB5/CDKN1A/TCF7/ADCY7/TCF7L2/SCARB1/CAMK2G/ITPR2/WNT2B/LDLR/CRH/EGFR/AHR/CACNA1C/FZD8/CDKN2A	2.27405290280283
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/564	59/9376	2.25411708137997	ADCY7/IRS2/PTGER3/MGLL/FABP4/PIK3R1/AKT3/PTGS2	2.4446347850914
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/564	59/9376	2.25411708137997	GADD45B/CDKN1A/TCF7/TCF7L2/EGFR/PIK3R1/AKT3/PDPK1	2.4446347850914
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/564	157/9376	1.69417716944482	ABCA1/C1QB/C1QA/DUSP2/CD36/C1QC/CAMK2G/RXRA/STAB2/CPT1A/GULP1/PTK2/PTGS2/PTGER4/JAK2/HAVCR2	2.21904541642816
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/564	107/9376	1.86438655796381	CREB5/PRKAG2/SIK1/FBP1/CAMK2G/PHKB/ITPR2/CPT1A/FOXO1/AKT3/PHKA2/CREBBP	2.27494760260815
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	23/564	253/9376	1.51128304319794	NFKBIA/JUN/SQSTM1/IL1B/CCL5/TECPR1/PLCD3/ITPR2/MAPK8/FOXO1/EGFR/PIK3R1/CD44/CAPN2/PTK2/AKT3/RPS6KA5/CD14/ATM/FNBP1/UBC/BCL2/MDM2	2.08564677681893
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/564	148/9376	1.68487636572743	FOS/JUN/GADD45B/CDKN1A/TCF7/TCF7L2/WNT2B/EGFR/PIK3R1/NFKB2/NCOA3/AKT3/NOTCH2/FZD8/CSNK1A1	2.12460006390732
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/564	98/9376	1.86597192068317	MARCKS/FCGR3A/ASAP3/INPPL1/VAV3/PTPRC/PIK3R1/AKT3/FCGR1A/FCGR2A/PRKCG	2.18010599850835
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/564	98/9376	1.86597192068317	CREB5/ADCY7/SCARB1/DAGLB/CAMK2G/ITPR2/NR4A2/LDLR/CACNA1C/PRKCG/ATP1B1	2.18010599850835
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	20/564	214/9376	1.55365546496984	HLA-B/NFKBIA/FOS/HLA-A/JUN/TAPBP/CXCR4/TAPBPL/ITPR2/MAPK8/PIK3R1/HLA-F/PTK2/AKT3/BST2/MAP2K3/CD4/ATM/PRKCG/BCL2	2.07271351867002
Human Diseases	Infectious disease: viral	hsa05162	Measles	14/564	136/9376	1.71130579891531	NFKBIA/FOS/HSPA1B/JUN/HSPA1A/IL1B/CD46/HSPA6/MAPK8/PIK3R1/MX2/AKT3/IL2RB/BCL2	2.11386751045458
NA	NA	hsa04517	IgSF CAM signaling	26/564	299/9376	1.44557508479803	PTPRF/BAIAP2/JAM2/TJP1/ESAM/ITGB2/CABLES1/MAG/TJP2/MAPK8/RASA1/CD84/CD48/FOXO1/VAV3/PIK3R1/IL1RAP/PTK2/AKT3/TUBB2A/PVR/CRTAM/PDPK1/PRKCG/ITGAX/MBP	1.98094889118032
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/564	42/9376	2.37487335359676	FTL/SAT1/ACSL5/HMOX1/ACSL3/CYBB	2.25913085864558
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	21/564	232/9376	1.50476889214967	FN1/TMSB4X/SSH2/RGCC/BAIAP2/PPP1R12B/ITGB2/PDGFB/CXCR4/VAV3/EGFR/PIK3R1/ITGB6/PTK2/AKT3/ITGA6/TIAM1/ITGA3/LPAR2/ITGAX/DIAPH2	1.96950193623814
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/564	90/9376	1.84712371946414	CREB5/PRKAG2/ADCY7/IRS2/FOXO1/PIK3R1/AKT3/SOD2/SESN3/ULK1	2.04287457405797
NA	NA	hsa04519	Cadherin signaling	33/564	404/9376	1.35791025911102	NFKBIA/VIM/TCF7/KRT15/EVL/TCF7L2/TJP1/CTNND2/AMOTL2/ANKRD6/TEAD1/GJA1/MAPK8/WNT2B/VAV3/KRT13/EGFR/PCDH1/FAT1/KRT7/TMC1/PTK2/FMN1/MAP2K3/KRT14/GABRE/CELSR1/MYO1D/FZD8/CSNK1A1/LHFPL2/TMC4/CREBBP	1.86040776368968
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/564	116/9376	1.71973587674248	JAM2/MMP9/ESAM/ITGB2/CXCR4/CD99L2/VAV3/PIK3R1/PTK2/NCF2/PRKCG/CYBB	1.97326130123518
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/564	116/9376	1.71973587674248	ADCY7/GLUL/HOMER3/HOMER1/SLC17A8/ITPR2/SLC1A3/CACNA1A/SLC1A6/CACNA1C/PRKCG/SLC38A2	1.97326130123518
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	22/564	250/9376	1.4629219858156	HLA-B/HSPA1B/HLA-A/CLTB/HSPA1A/ASAP3/CXCR4/ARFGAP3/HSPA6/LDLR/ACAP3/SH3GLB2/EGFR/HLA-F/AGAP3/TGFBR1/ARAP2/EHD1/IL2RB/SMAD3/MDM2/RAB11FIP1	1.87683254441818
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/564	79/9376	1.89388634527336	SLC6A2/CLTB/SLC17A8/SLC1A3/CACNA1A/VAMP2/ATP6V0A1/SLC1A6/ATP6V0D1	2.01842389680859
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	16/564	169/9376	1.57388056569726	SQSTM1/DAPK1/IRS2/CTSB/CTSD/ATG16L2/MAPK8/GABARAPL1/CFLAR/PIK3R1/ATG9B/AKT3/PDPK1/UBC/BCL2/ULK1	1.90455598946111
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/564	238/9376	1.46683354192741	RPS4Y1/NFKBIA/FOS/JUN/IL6ST/C1QB/C1QA/IL1B/C1QC/C5AR1/MAPK8/CCL2/EGFR/PIK3R1/MX2/HBEGF/FCGR2A/CXCL10/PRKCG/CYBB/C2	1.84549511565259
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/564	144/9376	1.61623325453113	KLF4/TCF7/IL6ST/ZFHX3/WNT2B/PIK3R1/JARID2/BMPR1B/AKT3/FZD8/JAK2/SMAD3/SKIL/SMAD4	1.88523904173642
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/564	93/9376	1.7875390833524	PTPRF/TCF7/BAIAP2/TCF7L2/TJP1/EGFR/TGFBR1/SMAD3/CREBBP/SMAD4	1.93088923286338
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/564	69/9376	1.92743344639737	FCER1G/ALOX5AP/MAPK8/VAV3/PIK3R1/AKT3/MAP2K3/PDPK1	1.9560970059602
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/564	69/9376	1.92743344639737	CREB5/FOSB/FOS/JUN/MAOA/CAMK2G/CACNA1C/PRKCG	1.9560970059602
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	16/564	174/9376	1.52865411265998	HSPA1B/HSP90AA1/MAN1A1/HSPA1A/DNAJB1/HSPA6/MAPK8/SEC31A/SEC24D/CAPN2/UBE2G2/HSPH1/SEC24A/MBTPS1/AMFR/BCL2	1.78070948002586
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/564	47/9376	2.12222725215029	IRS2/MAPK8/PIK3R1/SOCS1/CACNA1A/CACNA1C	1.95119259575105
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/564	71/9376	1.87313954649885	FOS/IRF1/MAPK8/PIK3R1/SOCS1/AKT3/JAK2/PRLR	1.86828269190058
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/564	122/9376	1.63515870247646	CREB5/PRKAG2/IRS2/CD36/FBP1/PFKFB3/CPT1A/FOXO1/PIK3R1/AKT3/PDPK1/ULK1	1.78642738061416
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/564	73/9376	1.82182065481395	GADD45B/CDKN1A/PDGFB/EGFR/PIK3R1/AKT3/MDM2/CDKN2A	1.78326102497467
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/564	138/9376	1.56603967519786	PTPRF/PRKAG2/IRS2/FBP1/PHKB/MAPK8/INPPL1/FOXO1/PIK3R1/SOCS1/AKT3/PHKA2/PDPK1	1.69467094387262
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/564	99/9376	1.67920338133104	IL1B/ADCY7/CAMK2G/ITPR2/MAPK8/PIK3R1/IL1RAP/MAP2K3/PTGER4/PRKCG	1.71870604425328
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/564	62/9376	1.87691603752002	TLE6/ATXN1/TLE4/NOTCH2/CREBBP/MAML2/TLE3	1.75256319374687
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/564	50/9376	1.99489361702128	IL1B/ITGB2/CD36/CCL2/THBS3/TGFB2	1.78443974234776
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/564	154/9376	1.51128304319794	FOS/JUN/CDKN1A/PRKAG2/ADCY7/PPP1R12B/RGS2/KCNJ2/CAMK2G/ITPR2/EGFR/PTGS2/CACNA1C/PRKCG	1.61844198769541
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/564	76/9376	1.74990668159761	ADCY7/KCNJ2/CAMK2G/SLC4A2/ITPR2/KCNJ15/PRKCG/ATP1B1	1.66058263055401
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/564	89/9376	1.68109012670332	ADCY7/TJP1/PDGFB/GJA1/ITPR2/EGFR/TUBB2A/MAP3K2/PRKCG	1.63323926060364
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/564	89/9376	1.68109012670332	ADCY7/GLUL/GABARAPL1/CACNA1A/GABRE/CACNA1C/PRKCG/ABAT/SLC38A2	1.63323926060364
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/564	226/9376	1.39760246030252	CREB5/NFKBIA/FOS/JUN/PDE10A/ADCY7/ACOX1/CAMK2G/PTGER3/PDE4C/MAPK8/CRH/VAV3/PIK3R1/AKT3/TIAM1/CACNA1C/CREBBP/ATP1B1	1.53066686722098
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/564	184/9376	1.44557508479803	SSH2/SEMA5A/CXCR4/EPHB2/EFNB2/CAMK2G/RASA1/RHOD/PIK3R1/SEMA4A/BMPR1B/PTK2/NTN4/DPYSL2/SEMA3C/PDPK1	1.54423271205241
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/564	157/9376	1.48240502326422	SERPINE1/TCF7/LLGL2/TCF7L2/ITGB2/TEAD1/WNT2B/BMPR1B/TGFBR1/TGFB2/AMOT/FZD8/SMAD3/SMAD4	1.54208277490963
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/564	90/9376	1.66241134751773	NFKBIA/FOS/JUN/EGFR/PIK3R1/AKT3/MAP2K3/CD4/JAK2	1.59743289949128
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/564	65/9376	1.79028914348063	SPP1/KISS1/ITPR2/PIK3R1/AKT3/CACNA1C/PRKCG	1.61745600579425
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/564	105/9376	1.58324890239784	JUN/SQSTM1/MAPK8/GABARAPL1/PINK1/ATG9B/TBC1D15/AMFR/UBC/ULK1	1.52045382371266
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/564	133/9376	1.49992001279795	HLA-B/TYROBP/HLA-A/FCER1G/TNFSF10/ITGB2/FCGR3A/CD48/VAV3/PIK3R1/HCST/PRKCG	1.46895270297569
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/564	248/9376	1.3406543125143	NFKBIA/FOS/TNFSF10/JUN/HSP90AA1/TCF7/IL1B/TCF7L2/RHOB/LY96/MAPK8/AHNAK2/DYNC1LI2/PTPRC/AKT3/TUBB2A/MAP2K3/CD14/DYNLT1/BCL2	1.37543433651366
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	17/564	205/9376	1.37858501989275	HLA-B/CREB5/NFKBIA/HLA-A/JUN/CDKN1A/IL6ST/REL/PIK3R1/NFKB2/HLA-F/RBL2/EGR3/ATP6V0D1/CREBBP/MDM2/CDKN2A	1.3865002597263
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/564	205/9376	1.37858501989275	MMP9/MT-ND2/CD36/CAMK2G/CTSD/MAPK8/PPIF/PIK3R1/AKT3/NCF2/TGFBR1/TGFB2/MT-ND4L/PRKCG/CYBB/SMAD3/TBC1D4	1.3865002597263
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/564	55/9376	1.81353965183752	HEXB/SGMS2/PSAP/ACER3/UGCG/ASAH1	1.53079403752056
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/564	149/9376	1.45042600790138	ADCY7/MT-ND2/SLC17A8/DAGLB/MGLL/ITPR2/MAPK8/CACNA1A/GABRE/MT-ND4L/PTGS2/CACNA1C/PRKCG	1.40208479266797
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/564	20/9376	2.4936170212766	GNE/UGDH/NPL	1.69159772114177
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/564	125/9376	1.4629219858156	FCER1G/SGMS2/CTSD/MAPK8/PIK3R1/AKT3/ORMDL1/ASAH1/PDPK1/PRKCG/BCL2	1.31812446084762
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/564	98/9376	1.52670429874077	PLCD3/INPP5B/ITPR2/DGKH/INPPL1/PIK3R1/SYNJ2/PRKCG/MTMR1	1.32599126334145
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/564	73/9376	1.59409307296221	CXCR4/MX2/BST2/CD4/ELL2/ELL/CREBBP	1.28911705493795
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/564	60/9376	1.66241134751773	HSPB1/PIK3R1/PTK2/AKT3/PTGS2/PRKCG	1.30219671305883
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	12/564	144/9376	1.38534278959811	ATXN1/ITPR2/MAPK8/PPIF/PIK3R1/VLDLR/AKT3/ATXN2/CACNA1A/SLC1A6/PRKCG/ULK1	1.17887709898863
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/564	130/9376	1.40665575559193	CREB5/NFKBIA/FOS/JUN/ADCY7/MMP9/MAPK8/EGFR/PIK3R1/AKT3/TGFBR1	1.18116236577064
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/564	63/9376	1.58324890239784	GADD45B/CDKN1A/TCF7/TCF7L2/WNT2B/FZD8	1.17507976945217
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/564	50/9376	1.66241134751773	AOC1/SAT1/MAOA/OAT/AMD1	1.18810002805304
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/564	38/9376	1.74990668159761	NT5E/NMNAT2/NAMPT/QPRT	1.17181764327712
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/564	38/9376	1.74990668159761	PIK3R1/PDPK1/PRKCG/ATP1B1	1.17181764327712
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/564	65/9376	1.53453355155483	CREB5/ADCY7/SCARB1/ITPR2/LDLR/CACNA1C	1.09401035101284
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/564	122/9376	1.36263225206371	NFKBIA/FOS/JUN/MAPK8/VAV3/PTPRC/PIK3R1/AKT3/CD4/PDPK1	1.01992806152948
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/564	80/9376	1.45460992907801	PDGFB/EGFR/PIK3R1/AKT3/PRKCG/BCL2/JAK2	1.03305584384617
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	17/564	227/9376	1.24497766113663	NFKBIA/FOS/JUN/MT-ND2/MAPK8/HMOX1/PPIF/EGFR/PIK3R1/PTK2/AKT3/NCF2/SOD2/AHR/GSTT1/MT-ND4L/PDPK1	0.94523663349442
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/564	168/9376	1.28638973319824	FTL/TNFSF10/HSP90AA1/SQSTM1/IL1B/GLUL/CAMK2G/MAPK8/CFLAR/CAPN2/BCL2/JAK2/CYBB	0.947583252356385
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	20/564	275/9376	1.20902643455835	CREB5/HSPA1B/EGR1/C1QB/C1QA/HSPA1A/IL1B/MT-ND2/CCL5/C1QC/HSPA6/ITPR2/MAPK8/PPIF/PIK3R1/TUBB2A/NCF2/MT-ND4L/CACNA1C/CYBB	0.890042916952927
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/564	170/9376	1.27125573633709	JUN/PRKAG2/LLGL2/JAM2/TJP1/AMOTL2/TJP2/MAPK8/MICALL2/SYMPK/TIAM1/RUNX1/AMOT	0.902933679383099
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/564	15/9376	2.21654846335697	ST3GAL5/HEXB	1.19289403619254
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	18/564	250/9376	1.19693617021277	CTSS/LAPTM5/CLTB/HEXB/PSAP/CTSB/IDS/CD68/CTSD/GGA1/CLCN7/CTSA/ASAH1/ATP6V0A1/ATP6V0D1/SLC11A1/ARSG/CTSF	0.798441691589103
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/564	85/9376	1.36904463913225	GDA/ENTPD1/NT5E/UPP1/TK2/AMPD3/AK9	0.864659425031878
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/564	57/9376	1.45825556799801	ACOX1/ACSL5/CPT1A/ACSL3/FADS2	0.87790691218514
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/564	43/9376	1.54642916048161	ACOX1/ACSL5/CPT1A/ACSL3	0.908542836462521
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/564	43/9376	1.54642916048161	ABCA1/SCARB1/CD36/SLC27A1	0.908542836462521
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/564	86/9376	1.35312551542141	CREB5/ADCY7/CAMK2G/VAMP2/CACNA1C/PRKCG/ATP1B1	0.83225883394369
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/564	86/9376	1.35312551542141	TCF7/TCF7L2/GJA1/ITGB6/ITGA6/ITGA3/CACNA1C	0.83225883394369
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/564	101/9376	1.31676146338038	TCF7/ADCY7/TCF7L2/CAMK2G/WNT2B/FZD8/PRKCG/CREBBP	0.809699767105267
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/564	238/9376	1.18743667679838	IGF2/RASGRF2/REL/PDGFB/MAPK8/RASA1/FLT1/EGFR/RASAL2/ETS2/PIK3R1/RALGDS/KSR1/AKT3/TIAM1/RASGRF1/PRKCG	0.740978186994434
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/564	254/9376	1.17808678170548	ADCY7/PDGFB/P2RX4/PLCD3/CXCR4/CAMK2G/PTGER3/PHKB/ITPR2/PPIF/FLT1/EGFR/CACNA1A/CASQ1/PHKA2/CACNA1C/PRKCG/STIM2	0.727933080248604
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/564	133/9376	1.24993334399829	CREB5/FOS/MAOA/CAMK2G/ITPR2/MAPK8/AKT3/CACNA1A/CACNA1C/PRKCG	0.734398007343688
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/564	103/9376	1.29119327962542	COL17A1/COL11A1/COL12A1/PRCP/SLC7A7/COL5A1/SLC38A2/ATP1B1	0.751757511448432
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/564	59/9376	1.40882317586248	ENTPD1/NT5E/UPP1/TK2/AK9	0.796913917770138
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/564	18/9376	1.84712371946414	ACSL5/ACSL3	0.910079894919408
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/564	120/9376	1.2468085106383	NFKBIA/JUN/CAMK2G/MAPK8/PIK3R1/AKT3/RPS6KA5/PDPK1/BCL2	0.688378071510796
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/564	90/9376	1.2929866036249	ADCY7/SCARB1/SLC4A2/RXRA/LDLR/AQP9/ATP1B1	0.706549550357909
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/564	32/9376	1.55851063829787	MAPK8/BIRC7/BCL2	0.800622830094455
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/564	200/9376	1.16368794326241	NFKBIA/FOS/TNFSF10/JUN/BAIAP2/IL1B/TJP1/MAPK8/SEC24D/TUBB2A/FCGR2A/SEC24A/MYO1D/LPAR2	0.591960779189679
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/564	19/9376	1.74990668159761	HEXB/IDS	0.827758510950704
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/564	33/9376	1.51128304319794	SNAP23/STX11/VAMP2	0.744325899573802
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/564	93/9376	1.25127735834668	LYZ/ADCY7/SLC4A2/ITPR2/VAMP2/PRKCG/ATP1B1	0.616082117002503
NA	NA	hsa03272	Virion - Hepatitis viruses	4/564	48/9376	1.38534278959811	HSPG2/SCARB1/LDLR/EGFR	0.677113594013864
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/564	63/9376	1.31937408533153	PLOD2/KMT2C/PIPOX/ASH1L/PRDM2	0.643447463025636
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/564	140/9376	1.18743667679838	SPP1/SERPINE1/EGR1/PRKAG2/ADCY7/ITPR2/AKT3/TGFBR1/SMAD3/SMAD4	0.565281246042889
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/564	156/9376	1.17221312965994	NFKBIA/CDKN1A/SCARB1/RXRA/LDLR/EGFR/CFLAR/PIK3R1/MX2/AKT3/CXCL10	0.548720321015562
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/564	49/9376	1.35707048776958	CREB5/FOSB/JUN/MAOA	0.633970360866047
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	11/564	157/9376	1.16474680399331	FOS/MLXIP/JUN/PRKAG2/IL1B/IRS2/RXRA/MAPK8/PIK3R1/AKT3/CEBPA	0.52663881263184
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/564	65/9376	1.27877795962902	GPAM/LPL/MGLL/PNPLA3/DGKH	0.570564696231437
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/564	51/9376	1.30385203726881	TJP1/TJP2/ATP6V0A1/ATP6V0D1	0.550440988770366
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/564	36/9376	1.38534278959811	GALNT7/B3GNT3/GALNT6	0.58602075179324
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/564	67/9376	1.24060548322219	CAMK2G/ITPR2/CACNA1C/PRKCG/CREBBP	0.500010762609737
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/564	52/9376	1.27877795962902	ADCY7/SCARB1/LDLR/PTGS2	0.509972691275585
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/564	83/9376	1.2017431427839	NFKBIA/CCL4/IL1B/CCL5/CXCL10/IFI16	0.467033255110233
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/564	22/9376	1.51128304319794	AOC1/MAOA	0.607382105999773
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/564	37/9376	1.34790109258194	GLUL/RIMKLB/ABAT	0.536406970684328
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/564	37/9376	1.34790109258194	IL1B/PRKCG/APOL1	0.536406970684328
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	13/564	195/9376	1.10827423167849	ITGB2/FCGR3A/C5AR1/PPIF/PIK3R1/AKT3/NCF2/FCGR1A/FCGR2A/AQP9/PRKCG/CYBB/FPR3	0.386531924071645
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/564	212/9376	1.0978188143985	ADCY7/EVL/ITGB2/PDGFB/FLT1/VAV3/EGFR/PIK3R1/RALGDS/AKT3/MAP2K3/TIAM1/LPAR2/PRKCG	0.364448133922352
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/564	69/9376	1.20464590399836	CTSB/KCNJ2/ITPR2/CACNA1C/PTGER4	0.431629074461572
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/564	38/9376	1.31243001119821	HEXB/GNE/UGDH	0.488208744361845
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/564	23/9376	1.44557508479803	HMGCS1/IDI1	0.541249234596817
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/564	23/9376	1.44557508479803	CTSA/PRCP	0.541249234596817
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/564	54/9376	1.2314158129761	SDS/DNMT1/BCAT1/AMD1	0.431442881825988
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/564	24/9376	1.38534278959811	EXTL3/NDST1	0.478176858799549
NA	NA	hsa04382	Cornified envelope formation	14/564	217/9376	1.07252345001144	COL17A1/KRT15/TJP1/SLC27A1/S100A9/LAMA5/S100A8/KRT13/LAMA3/KRT7/ITGA6/UGCG/KRT14/SPRR2G	0.273446418232966
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/564	104/9376	1.1189307146754	SGMS2/GDPD5/GPAM/LPCAT1/DGKH/LCAT/LYPLA1	0.308540325082802
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/564	56/9376	1.18743667679838	IQCE/CSNK1A1/BCL2/MGRN1	0.355900484325352
NA	NA	hsa04081	Hormone signaling	14/564	219/9376	1.06272871530814	CSH1/IGF2/CSH2/ADCY7/IRS2/HAMP/CRH/PIK3R1/BMPR1B/THRB/JAK2/CSHL1/PRLR/SMAD4	0.237629191016602
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/564	41/9376	1.21639854696419	MAOA/SDS/PIPOX	0.351299113202673
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/564	41/9376	1.21639854696419	SLC17A8/CACNA1A/GABRE	0.351299113202673
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/564	26/9376	1.27877795962902	ACOX1/FADS2	0.36010342304329
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/564	91/9376	1.09609539396773	PDE10A/ADCY7/PDE4C/CACNA1A/GABRE/PRKCG	0.233034520402068
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/564	75/9376	1.10827423167849	CREB5/ADCY7/ITPR2/PRKCG/ATP1B1	0.238165508276433
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	10/564	158/9376	1.05215908070742	GADD45B/CDKN1A/TGFB2/ATM/RBL2/SMAD3/CREBBP/MDM2/CDKN2A/SMAD4	0.167273855073529
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/564	27/9376	1.2314158129761	HMGCS1/ABAT	0.3046353374585
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/564	27/9376	1.2314158129761	ACOX1/FADS2	0.3046353374585
Organismal Systems	Immune system	hsa04611	Platelet activation	8/564	126/9376	1.05549926826523	FCER1G/ADCY7/SNAP23/ITPR2/PIK3R1/AKT3/FERMT3/FCGR2A	0.158668095644386
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/564	60/9376	1.10827423167849	ITPR2/CRH/CACNA1A/PRKCG	0.212850140821179
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/564	44/9376	1.13346228239845	CREB5/DYNC1LI2/VAMP2	0.224484038501678
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/564	128/9376	1.03900709219858	PDE10A/ADCY7/GDA/PDE4C/ENTPD1/NT5E/AMPD3/AK9	0.112411979903718
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/564	78/9376	1.06564829969085	PLCD3/INPP5B/INPPL1/SYNJ2/MTMR1	0.147286844748017
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/564	28/9376	1.18743667679838	ATP6V0A1/ATP6V0D1	0.251282466039353
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/564	12/9376	1.38534278959811	CD46	0.33790537765986
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/564	97/9376	1.02829567887695	FOS/ADCY7/CAMK2G/RPS6KA5/CACNA1C/PRKCG	0.0708668850548929
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/564	115/9376	1.01190255935862	DUSP1/MAOA/ITPR2/CACNA1A/PTGS2/CACNA1C/PRKCG	0.0324898929218537
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/564	149/9376	1.00414108239326	FCER1G/ADCY7/PDGFB/DGKH/EGFR/PIK3R1/RALGDS/AKT3/LPAR2	0.0128903494623388
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/564	166/9376	1.00145261898658	CREB5/ADCY7/IRS2/RGS2/ITPR2/PPIF/AKT3/GTF2I/CACNA1C/ATP1B1	0.00477709514549133
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/564	99/9376	1.00752202879862	PRKAG2/ITGB6/ITGA6/TGFB2/ITGA3/CACNA1C	0.0190342932862138
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/564	48/9376	1.03900709219858	BCAT1/HMGCS1/ABAT	0.0685421736271704
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/564	48/9376	1.03900709219858	PIK3R1/AKT3/ATP1B1	0.0685421736271704
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/564	31/9376	1.07252345001144	FBP1/H6PD	0.10231930834272
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/564	31/9376	1.07252345001144	ACOX1/ABAT	0.10231930834272
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/564	83/9376	1.00145261898658	JARID2/PHF1/LCOR/CREBBP/PHC2	0.00336279768609672
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/564	83/9376	1.00145261898658	ACOX1/ACSL5/PIPOX/ACSL3/SOD2	0.00336279768609672
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/564	32/9376	1.03900709219858	ACOX1/ABAT	0.055916515117708
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/564	32/9376	1.03900709219858	GABARAPL1/ATG9B	0.055916515117708
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/564	68/9376	0.977889027951606	RDH10/CYP26A1/ALDH1A1/RDH13	-0.0462937168029765
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/564	103/9376	0.968394959719066	FUS/MSI2/PABPC1/NXF1/SYMPK/UPF2	-0.0815929765322369
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	28/564	480/9376	0.969739952718676	FUS/DNAH11/SQSTM1/IL1B/HIP1/MT-ND2/ATXN1/CAMK2G/ITPR2/MAPK8/WNT2B/PPIF/PINK1/CAPN2/UBE2G2/TUBB2A/MAP2K3/ATXN2/MT-ND4L/PTGS2/CACNA1C/FZD8/PRKCG/CSNK1A1/UBC/BCL2/CYBB/ULK1	-0.172179237338063
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/564	105/9376	0.949949341438703	ADCY7/ITGB6/ITGA6/TGFB2/ITGA3/CACNA1C	-0.130475539475516
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/564	34/9376	0.977889027951606	PRKAG2/CRY1	-0.0326749783552331
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/564	53/9376	0.940987555198715	CLTB/PRKCG/ATP1B1	-0.108991253112362
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/564	142/9376	0.936569773249426	HERC1/BIRC7/SOCS1/UBE2G2/PPIL2/UBC/MGRN1/MDM2	-0.192678584417553
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/564	16/9376	1.03900709219858	MAOA	0.0395051385940144
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/564	16/9376	1.03900709219858	HEXB	0.0395051385940144
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/564	35/9376	0.949949341438703	FBP1/PFKFB3	-0.0750473010763063
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/564	17/9376	0.977889027951606	CYP27A1	-0.0230837051593658
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/564	17/9376	0.977889027951606	GLUL	-0.0230837051593658
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/564	17/9376	0.977889027951606	PCDH1	-0.0230837051593658
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/564	110/9376	0.906769825918762	HSP90AA1/ADCY7/MAPK8/PIK3R1/AKT3/CPEB2	-0.248825356943019
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/564	37/9376	0.898600728387962	GNE/UGDH	-0.156341205229757
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/564	18/9376	0.923561859732072	HEXB	-0.0821188370299372
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/564	38/9376	0.874953340798805	PTPRC/CD4	-0.195400154553427
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/564	78/9376	0.852518639752682	FN1/CLTB/PIK3R1/PTK2	-0.330885404683217
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/564	41/9376	0.810932364642795	ATM/TOP3B	-0.306930400264206
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/564	154/9376	0.863590310398821	CREB5/ADCY7/CAMK2G/AKT3/RPS6KA5/CACNA1C/BCL2/ATP1B1	-0.43179833971841
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/564	61/9376	0.817579351238228	FTL/HMOX1/ATP1B1	-0.361605834977164
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	21/564	388/9376	0.899758719017328	APOE/IL1B/MT-ND2/IRS2/LPL/ITPR2/MAPK8/WNT2B/PPIF/PIK3R1/CAPN2/AKT3/TUBB2A/MT-ND4L/SLC39A13/PTGS2/CACNA1C/FZD8/CSNK1A1/CYBB/ULK1	-0.510174661200035
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/564	42/9376	0.791624451198919	AOC1/MAOA	-0.342393451187503
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/564	21/9376	0.791624451198919	DSE	-0.241836837002475
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/564	21/9376	0.791624451198919	BCAT1	-0.241836837002475
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/564	63/9376	0.791624451198919	HPGD/PTGES/PTGS2	-0.419817149827442
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/564	158/9376	0.841727264565939	WNT2B/PIK3R1/AKT3/FNIP1/PDPK1/FZD8/PRKCG/ULK1	-0.507579701367696
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/564	102/9376	0.814907523293005	ADCY7/SLC4A2/ITPR2/PRKCG/ATP1B1	-0.475492041938332
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/564	44/9376	0.755641521598968	MAN1A1/HEXB	-0.411011838609353
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/564	44/9376	0.755641521598968	TAF4B/GTF2I	-0.411011838609353
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/564	23/9376	0.722787542399013	GLUL	-0.336735682977535
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/564	23/9376	0.722787542399013	ATP1B1	-0.336735682977535
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/564	45/9376	0.738849487785658	ABCA1/ABCG1	-0.444243405913278
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/564	46/9376	0.722787542399013	FTL/HMOX1	-0.476802784485024
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/564	26/9376	0.639388979814512	SCARB1	-0.465808928828992
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/564	49/9376	0.678535243884788	GALNT7/GALNT6	-0.57075321097831
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/564	71/9376	0.702427329937069	EGFR/PIK3R1/AKT3	-0.636725104584353
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/564	72/9376	0.692671394799054	NFKBIA/MAPK8/CXCL10	-0.662250550896374
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/564	51/9376	0.651926018634404	LPCAT1/PLA2G7	-0.630550935877448
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/564	28/9376	0.593718338399189	B3GNT3	-0.5446717236853
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/564	134/9376	0.744363289933312	ADCY7/PPP1R12B/ADM/ITPR2/CACNA1C/PRKCG	-0.754016036815044
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	13/564	268/9376	0.806393564094422	DUSP1/MT-ND2/MAOA/CAMK2G/ITPR2/MAPK8/PPIF/PINK1/UBE2G2/TUBB2A/MT-ND4L/SLC39A13/UBC	-0.81351136045682
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/564	154/9376	0.755641521598968	BCAT1/PDXK/NMNAT2/AK9/RDH13/UGDH/QPRT	-0.773505060954047
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/564	29/9376	0.573245292247493	TEAD1	-0.582276341061057
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/564	75/9376	0.664964539007092	GLUL/SDS/BCAT1	-0.736961044387252
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/564	54/9376	0.615707906488048	TOP3B/ERCC1	-0.716459632362565
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/564	30/9376	0.554137115839243	IL1B	-0.618781051300251
NA	NA	hsa04082	Neuroactive ligand signaling	9/564	199/9376	0.751844328023094	SLC6A2/ADCY7/TAC3/P2RX4/SLC17A8/SLC1A3/GABRE/SLC1A6/PRKCG	-0.895134558781984
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/564	31/9376	0.536261725005719	UGDH	-0.654262580475374
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/564	31/9376	0.536261725005719	GLUL	-0.654262580475374
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/564	56/9376	0.593718338399189	MAN1A1/MGAT5	-0.771438347105224
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/564	32/9376	0.519503546099291	GALM	-0.688789799859039
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/564	33/9376	0.503761014399312	BCAT1	-0.722424759191218
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/564	243/9376	0.752531885707615	FUS/HSPA1B/HSPA1A/SRSF5/HSPA6/DDX5/SF1/TRA2A/SRSF6/SF3B1/SRSF7	-0.988788946657799
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/564	82/9376	0.608199273482096	GSTT1/UPP1/TK2	-0.901485560961695
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/564	34/9376	0.488944513975803	CRCP	-0.755223556323784
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/564	36/9376	0.461780929866036	UGDH	-0.81851160219792
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/564	308/9376	0.755641521598968	CREB5/DNAH11/CLTB/HIP1/MT-ND2/TAF4B/MAPK8/SLC1A3/PPIF/TUBB2A/SOD2/MT-ND4L/ULK1/CREBBP	-1.10315099395397
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/564	37/9376	0.449300364193981	MAOA	-0.849089381143843
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/564	63/9376	0.527749634132613	UVSSA/ERCC1	-0.95144945625398
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/564	194/9376	0.685530452584631	DNAH11/KIF21A/MYO7B/DYNC1LI2/KIF12/TUBB2A/DYNLT1/MYO1D	-1.11969248230622
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/564	235/9376	0.707409084050098	CREB5/PRKAG2/ADCY7/MT-ND2/MGLL/ACSL5/CPT1A/ACSL3/MAP2K3/MT-ND4L	-1.14917418406797
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/564	67/9376	0.496242193288875	GALM/FBP1	-1.04687691124494
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/564	116/9376	0.573245292247493	ACOX1/FBP1/SDS/H6PD	-1.17001052349826
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/564	70/9376	0.474974670719352	GSTT1/PTGS2	-1.11541298974609
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/564	73/9376	0.455455163703488	MAOA/GSTT1	-1.18160279524566
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	16/564	370/9376	0.71888058271037	CSH1/CSH2/KISS1/TAC3/P2RX4/ADM/PTGER3/C5AR1/CRH/GABRE/LPAR2/PTGER4/THRB/FPR3/CSHL1/PRLR	-1.39576942482221
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/564	78/9376	0.426259319876341	PABPC1/CNOT6L	-1.28722990354568
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/564	86/9376	0.386607290120402	CACNA1A/CACNA1C	-1.44566585868126
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	4/564	138/9376	0.481858361599342	MT-ND2/ATP6V0A1/MT-ND4L/ATP6V0D1	-1.5512686086911
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/564	138/9376	0.481858361599342	ADCY7/CAMK2G/ITPR2/CPEB2	-1.5512686086911
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/564	87/9376	0.382163528164995	CACNA1C/ATP1B1	-1.46465936433394
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/564	59/9376	0.281764635172497	GSTT1	-1.40004723865821
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/564	117/9376	0.426259319876341	BAZ2B/SMARCA1/MORF4L2	-1.57984499508473
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	13/564	368/9376	0.587264878199198	FUS/DNAH11/SQSTM1/MT-ND2/NXF1/PINK1/TUBB2A/MAP2K3/ATXN2/MT-ND4L/SRSF7/BCL2/ULK1	-2.04347389186485
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/564	108/9376	0.307853953244024	NXF1/UPF2	-1.83022529735849
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/564	79/9376	0.210431816141485	GSTT1	-1.78287015892654
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/564	191/9376	0.348148973302143	CREB5/FOSB/MAOA/CRH	-2.30257297529356
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/564	183/9376	0.0908421501375809	NXF1	-3.14213003183459
Genetic Information Processing	Translation	hsa03010	Ribosome	1/564	222/9376	0.0748833940323302	RPS4Y1	-3.52903085747923
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/564	449/9376	0.111074254845283	RGS2/CAMK2G/NCALD	-4.88341725646613