ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0023026 MHC class II protein complex binding 14/1011 27/18639 0.518518518518518 9.55951203428948 1.8060195684356e-11 1.20584847598686e-08 GO:0023023 MHC protein complex binding 16/1011 37/18639 0.432432432432432 7.97241158072019 2.18847273318849e-11 1.20584847598686e-08 GO:0140375 immune receptor activity 30/1011 156/18639 0.192307692307692 3.54542341931066 1.15585517698772e-09 4.24584135013488e-07 GO:0042277 peptide binding 38/1011 249/18639 0.152610441767068 2.81355689821601 7.26406074532193e-09 2.00124873533619e-06 GO:0042605 peptide antigen binding 14/1011 45/18639 0.311111111111111 5.73570722057369 5.99689242973349e-08 1.32171509151326e-05 GO:0019955 cytokine binding 25/1011 144/18639 0.173611111111111 3.20072947576657 2.22815569415024e-07 4.09237929158927e-05 GO:0071813 lipoprotein particle binding 11/1011 32/18639 0.34375 6.3374443620178 5.09563738246851e-07 7.01924049435037e-05 GO:0071814 protein-lipid complex binding 11/1011 32/18639 0.34375 6.3374443620178 5.09563738246851e-07 7.01924049435037e-05 GO:0001540 amyloid-beta binding 17/1011 83/18639 0.204819277108434 3.77608952128991 1.82443135356414e-06 0.000215816268157469 GO:0030228 lipoprotein particle receptor activity 8/1011 18/18639 0.444444444444444 8.19386745796241 1.95840533718211e-06 0.000215816268157469 GO:0043394 proteoglycan binding 11/1011 37/18639 0.297297297297297 5.48103296174513 2.62904384751161e-06 0.000261847400126098 GO:0005539 glycosaminoglycan binding 32/1011 242/18639 0.132231404958678 2.43784486352601 2.85133285073791e-06 0.000261847400126098 GO:0032395 MHC class II receptor activity 6/1011 10/18639 0.6 11.0617210682493 4.36495218366764e-06 0.00037001363895398 GO:0030695 GTPase regulator activity 51/1011 489/18639 0.104294478527607 1.92279405071817 5.92201813798548e-06 0.000427119245209474 GO:0005041 low-density lipoprotein particle receptor activity 7/1011 15/18639 0.466666666666667 8.60356083086053 5.92851371496592e-06 0.000427119245209474 GO:0060589 nucleoside-triphosphatase regulator activity 51/1011 490/18639 0.104081632653061 1.91886998122691 6.27261872528927e-06 0.000427119245209474 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 40/1011 349/18639 0.114613180515759 2.11303172268372 6.58895387346738e-06 0.000427119245209474 GO:0038024 cargo receptor activity 14/1011 65/18639 0.215384615384615 3.97087422962794 7.93673950136966e-06 0.000485904829472743 GO:0140297 DNA-binding transcription factor binding 50/1011 488/18639 0.102459016393443 1.8889551004524 1.18666031488025e-05 0.000688262982630547 GO:0019838 growth factor binding 21/1011 136/18639 0.154411764705882 2.84676645138768 1.36363775958171e-05 0.000751364405529521 GO:0005126 cytokine receptor binding 33/1011 275/18639 0.12 2.21234421364985 1.62039942742284e-05 0.000815378582832212 GO:0030169 low-density lipoprotein particle binding 7/1011 17/18639 0.411764705882353 7.59137720370047 1.62779753378481e-05 0.000815378582832212 GO:0050431 transforming growth factor beta binding 8/1011 24/18639 0.333333333333333 6.14540059347181 2.45829794106186e-05 0.00116584386375202 GO:0034185 apolipoprotein binding 7/1011 18/18639 0.388888888888889 7.16963402571711 2.53904289746357e-05 0.00116584386375202 GO:0005518 collagen binding 14/1011 72/18639 0.194444444444444 3.58481701285856 2.7285520913135e-05 0.00120274576185099 GO:0005201 extracellular matrix structural constituent 23/1011 168/18639 0.136904761904762 2.52400381517592 3.9700425956949e-05 0.00168268728479068 GO:0140311 protein sequestering activity 9/1011 33/18639 0.272727272727273 5.02805503102239 4.63842776563473e-05 0.00189316570286277 GO:0004896 cytokine receptor activity 16/1011 96/18639 0.166666666666667 3.0727002967359 5.50273539400304e-05 0.00214029861315592 GO:0008201 heparin binding 23/1011 172/18639 0.133720930232558 2.4653060520323 5.76697976531373e-05 0.00214029861315592 GO:0001216 DNA-binding transcription activator activity 48/1011 491/18639 0.0977596741344195 1.80231707832982 5.82658424634097e-05 0.00214029861315592 GO:0005044 scavenger receptor activity 8/1011 27/18639 0.296296296296296 5.46257830530828 6.41566914512746e-05 0.00228066690255821 GO:0005096 GTPase activator activity 31/1011 271/18639 0.114391143911439 2.10893821104383 7.24387573039367e-05 0.00249460970465432 GO:0046332 SMAD binding 14/1011 79/18639 0.177215189873418 3.26717499906096 7.97783056058945e-05 0.00264289537024655 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 47/1011 484/18639 0.0971074380165289 1.79029232165191 8.15412364685869e-05 0.00264289537024655 GO:0005114 type II transforming growth factor beta receptor binding 5/1011 11/18639 0.454545454545455 8.38009171837065 0.000163180776112542 0.00499514486877837 GO:0019864 IgG binding 5/1011 11/18639 0.454545454545455 8.38009171837065 0.000163180776112542 0.00499514486877837 GO:0005178 integrin binding 21/1011 161/18639 0.130434782608696 2.40472197135853 0.00017002388179922 0.00506395453358758 GO:0033218 amide binding 28/1011 247/18639 0.11336032388664 2.08993380506734 0.000185168455742531 0.00536988521653339 GO:0005078 MAP-kinase scaffold activity 5/1011 12/18639 0.416666666666667 7.68175074183976 0.000267253838751564 0.00736284325760559 GO:0035259 nuclear glucocorticoid receptor binding 5/1011 12/18639 0.416666666666667 7.68175074183976 0.000267253838751564 0.00736284325760559 GO:0097110 scaffold protein binding 12/1011 70/18639 0.171428571428571 3.1604917337855 0.000350195124778441 0.00939937972627008 GO:0070412 R-SMAD binding 7/1011 26/18639 0.269230769230769 4.96359278703492 0.000358234073052036 0.00939937972627008 GO:0004674 protein serine/threonine kinase activity 41/1011 433/18639 0.0946882217090069 1.74569116165596 0.000383697409767635 0.00983336152474266 GO:0019207 kinase regulator activity 30/1011 287/18639 0.104529616724739 1.92712910596677 0.000455067904284621 0.0113973825118557 GO:0003779 actin binding 41/1011 443/18639 0.0925507900677201 1.70628504062536 0.00060809710713316 0.0148916224902387 GO:0140313 molecular sequestering activity 10/1011 55/18639 0.181818181818182 3.35203668734826 0.000663345020141624 0.0158914393955667 GO:0019887 protein kinase regulator activity 27/1011 255/18639 0.105882352941176 1.95206842380869 0.000704114189876996 0.0165092305796691 GO:0003714 transcription corepressor activity 23/1011 204/18639 0.112745098039216 2.0785913772037 0.000723706571459062 0.016615096703081 GO:0050840 extracellular matrix binding 11/1011 67/18639 0.164179104477612 3.02683909827716 0.000890118449281468 0.0200185822675138 GO:0035925 mRNA 3'-UTR AU-rich region binding 7/1011 30/18639 0.233333333333333 4.30178041543027 0.000916917364397048 0.0202088587113109 GO:1990841 promoter-specific chromatin binding 11/1011 68/18639 0.161764705882353 2.98232675859661 0.00101079217751992 0.0218410388162148 GO:1901681 sulfur compound binding 28/1011 275/18639 0.101818181818182 1.87714054491503 0.0010419162973674 0.0220806107634399 GO:0005024 transforming growth factor beta receptor activity 5/1011 16/18639 0.3125 5.76131305637982 0.00122872061978752 0.0255481155284123 GO:0001618 virus receptor activity 12/1011 81/18639 0.148148148148148 2.73128915265414 0.0013479947921644 0.0273198769574504 GO:0001221 transcription coregulator binding 15/1011 115/18639 0.130434782608696 2.40472197135853 0.00138311610053621 0.0273198769574504 GO:0005131 growth hormone receptor binding 4/1011 10/18639 0.4 7.37448071216617 0.00138830590709367 0.0273198769574504 GO:0140272 exogenous protein binding 12/1011 82/18639 0.146341463414634 2.69798074835348 0.00150276336441335 0.0289681532254675 GO:0015026 coreceptor activity 10/1011 61/18639 0.163934426229508 3.02232816072384 0.00152463964344566 0.0289681532254675 GO:0071889 14-3-3 protein binding 7/1011 33/18639 0.212121212121212 3.91070946857297 0.00166945836436746 0.0311820867378465 GO:0008432 JUN kinase binding 4/1011 11/18639 0.363636363636364 6.70407337469652 0.00208837741051146 0.0372457023657302 GO:0042608 T cell receptor binding 4/1011 11/18639 0.363636363636364 6.70407337469652 0.00208837741051146 0.0372457023657302 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 5/1011 18/18639 0.277777777777778 5.12116716122651 0.00220145878176974 0.0372457023657302 GO:0004857 enzyme inhibitor activity 37/1011 416/18639 0.0889423076923077 1.63975833143118 0.00220689526420103 0.0372457023657302 GO:0001223 transcription coactivator binding 8/1011 44/18639 0.181818181818182 3.35203668734826 0.00225914971590674 0.0372457023657302 GO:0005160 transforming growth factor beta receptor binding 6/1011 26/18639 0.230769230769231 4.25450810317279 0.00226448462659158 0.0372457023657302 GO:0019865 immunoglobulin binding 6/1011 26/18639 0.230769230769231 4.25450810317279 0.00226448462659158 0.0372457023657302 GO:0043548 phosphatidylinositol 3-kinase binding 6/1011 26/18639 0.230769230769231 4.25450810317279 0.00226448462659158 0.0372457023657302 GO:0008009 chemokine activity 8/1011 45/18639 0.177777777777778 3.27754698318497 0.00261935072078768 0.0424488896221768 GO:0019209 kinase activator activity 17/1011 148/18639 0.114864864864865 2.1176718261288 0.00278756414860476 0.0429198830444589 GO:0015245 fatty acid transmembrane transporter activity 5/1011 19/18639 0.263157894736842 4.85163204747774 0.0028556900823719 0.0429198830444589 GO:0043395 heparan sulfate proteoglycan binding 5/1011 19/18639 0.263157894736842 4.85163204747774 0.0028556900823719 0.0429198830444589 GO:0002020 protease binding 16/1011 136/18639 0.117647058823529 2.16896491534299 0.00287574290932247 0.0429198830444589 GO:0035497 cAMP response element binding 4/1011 12/18639 0.333333333333333 6.14540059347181 0.00299893919639141 0.0429198830444589 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 4/1011 12/18639 0.333333333333333 6.14540059347181 0.00299893919639141 0.0429198830444589 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 4/1011 12/18639 0.333333333333333 6.14540059347181 0.00299893919639141 0.0429198830444589 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 4/1011 12/18639 0.333333333333333 6.14540059347181 0.00299893919639141 0.0429198830444589 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 4/1011 12/18639 0.333333333333333 6.14540059347181 0.00299893919639141 0.0429198830444589 GO:0016922 nuclear receptor binding 16/1011 137/18639 0.116788321167883 2.15313305464706 0.00309648784849803 0.0437478155005747 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 6/1011 29/18639 0.206896551724138 3.81438657525836 0.00406681602571439 0.0564249399737245 GO:0008035 high-density lipoprotein particle binding 4/1011 13/18639 0.307692307692308 5.67267747089706 0.00414738669498338 0.0564249399737245 GO:0035325 Toll-like receptor binding 4/1011 13/18639 0.307692307692308 5.67267747089706 0.00414738669498338 0.0564249399737245 GO:0106310 protein serine kinase activity 32/1011 361/18639 0.0886426592797784 1.63423395283461 0.00444354553291409 0.0597169167959918 GO:0016763 pentosyltransferase activity 8/1011 49/18639 0.163265306122449 3.00999212741476 0.00452815448345695 0.060120798081561 GO:0045296 cadherin binding 30/1011 334/18639 0.0898203592814371 1.65594626770198 0.00477703363928824 0.0622026551340718 GO:0008013 beta-catenin binding 13/1011 106/18639 0.122641509433962 2.26104361457925 0.00481080843816408 0.0622026551340718 GO:0001968 fibronectin binding 6/1011 30/18639 0.2 3.68724035608309 0.00485429069104372 0.0622026551340718 GO:0001217 DNA-binding transcription repressor activity 26/1011 278/18639 0.0935251798561151 1.72424908737698 0.00491952699298449 0.0623140085778035 GO:0042379 chemokine receptor binding 10/1011 72/18639 0.138888888888889 2.56058358061325 0.00530582854065705 0.0664434437705008 GO:0019763 immunoglobulin receptor activity 4/1011 14/18639 0.285714285714286 5.26748622297584 0.00555965156242674 0.0683587301391761 GO:0004860 protein kinase inhibitor activity 11/1011 84/18639 0.130952380952381 2.41426451886393 0.00558283639975122 0.0683587301391761 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 5/1011 23/18639 0.217391304347826 4.00786995226422 0.00690211793738413 0.0826753692064925 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 5/1011 23/18639 0.217391304347826 4.00786995226422 0.00690211793738413 0.0826753692064925 GO:0019902 phosphatase binding 19/1011 190/18639 0.1 1.84362017804154 0.00752536239757329 0.0891714985174814 GO:0004712 protein serine/threonine/tyrosine kinase activity 7/1011 43/18639 0.162790697674419 3.00124215030019 0.00786906673811699 0.0914887613324986 GO:0030296 protein tyrosine kinase activator activity 6/1011 33/18639 0.181818181818182 3.35203668734826 0.00788696218383609 0.0914887613324986 GO:0030295 protein kinase activator activity 15/1011 139/18639 0.107913669064748 1.98951817774267 0.0084858071769432 0.0974099948853272 GO:0051427 hormone receptor binding 6/1011 34/18639 0.176470588235294 3.25344737301449 0.00914731926595785 0.103873834793137 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/1011 16/18639 0.25 4.60905044510386 0.00927029023350547 0.103873834793137 GO:0019210 kinase inhibitor activity 11/1011 90/18639 0.122222222222222 2.25331355093966 0.00933167844330363 0.103873834793137 GO:0033293 monocarboxylic acid binding 10/1011 79/18639 0.126582278481013 2.33369642790069 0.0101579011118849 0.111940070252972 GO:0141003 histone H2AX kinase activity 30/1011 354/18639 0.0847457627118644 1.56238998139114 0.0105787186031517 0.115423246541318 GO:1990782 protein tyrosine kinase binding 13/1011 117/18639 0.111111111111111 2.0484668644906 0.0108726787571431 0.117467568533056 GO:0048306 calcium-dependent protein binding 10/1011 80/18639 0.125 2.30452522255193 0.011061867162029 0.118351238956853 GO:0019903 protein phosphatase binding 15/1011 144/18639 0.104166666666667 1.92043768545994 0.01156629550098 0.121858374366949 GO:0036041 long-chain fatty acid binding 4/1011 17/18639 0.235294117647059 4.33792983068598 0.0116108251438563 0.121858374366949 GO:0140996 histone H3 kinase activity 30/1011 357/18639 0.0840336134453782 1.54926065381642 0.0118115238937662 0.12279527670689 GO:0005179 hormone activity 14/1011 132/18639 0.106060606060606 1.95535473428649 0.0124250971941317 0.127966888859188 GO:0003712 transcription coregulator activity 39/1011 495/18639 0.0787878787878788 1.45254923118425 0.0126249555050129 0.128821305245595 GO:0005504 fatty acid binding 7/1011 47/18639 0.148936170212766 2.74581728644485 0.0127424837721959 0.128827679972109 GO:0035173 histone kinase activity 30/1011 360/18639 0.0833333333333333 1.53635014836795 0.0131586707117433 0.131825955675828 GO:0042805 actinin binding 6/1011 37/18639 0.162162162162162 2.98965434277007 0.0137826310880907 0.136832968099783 GO:0015172 acidic amino acid transmembrane transporter activity 4/1011 18/18639 0.222222222222222 4.09693372898121 0.0142992155330238 0.137284600754447 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3/1011 10/18639 0.3 5.53086053412463 0.0143264329280956 0.137284600754447 GO:0004955 prostaglandin receptor activity 3/1011 10/18639 0.3 5.53086053412463 0.0143264329280956 0.137284600754447 GO:0070513 death domain binding 3/1011 10/18639 0.3 5.53086053412463 0.0143264329280956 0.137284600754447 GO:0097718 disordered domain specific binding 5/1011 28/18639 0.178571428571429 3.2921788893599 0.0161226768786209 0.153165430346899 GO:0005125 cytokine activity 21/1011 234/18639 0.0897435897435897 1.65453092901164 0.0164940144028329 0.155353879247196 GO:0048020 CCR chemokine receptor binding 7/1011 50/18639 0.14 2.58106824925816 0.0176029622825704 0.164393766401632 GO:0004629 phospholipase C activity 5/1011 29/18639 0.172413793103448 3.17865547938197 0.0186343145563097 0.166760844235225 GO:0043236 laminin binding 5/1011 29/18639 0.172413793103448 3.17865547938197 0.0186343145563097 0.166760844235225 GO:0004954 prostanoid receptor activity 3/1011 11/18639 0.272727272727273 5.02805503102239 0.0189157037471897 0.166760844235225 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/1011 11/18639 0.272727272727273 5.02805503102239 0.0189157037471897 0.166760844235225 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/1011 11/18639 0.272727272727273 5.02805503102239 0.0189157037471897 0.166760844235225 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/1011 11/18639 0.272727272727273 5.02805503102239 0.0189157037471897 0.166760844235225 GO:0047676 arachidonate-CoA ligase activity 3/1011 11/18639 0.272727272727273 5.02805503102239 0.0189157037471897 0.166760844235225 GO:0051015 actin filament binding 19/1011 209/18639 0.0909090909090909 1.67601834367413 0.0193164405520313 0.168942202288401 GO:0044183 protein folding chaperone 9/1011 75/18639 0.12 2.21234421364985 0.0198495461834733 0.171393333063982 GO:0004713 protein tyrosine kinase activity 14/1011 140/18639 0.1 1.84362017804154 0.0199077555646004 0.171393333063982 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 23/1011 268/18639 0.0858208955223881 1.5822113468267 0.0202383518368226 0.172888866078903 GO:0051721 protein phosphatase 2A binding 5/1011 30/18639 0.166666666666667 3.0727002967359 0.0213903193293629 0.18132409154583 GO:0015294 solute:monoatomic cation symporter activity 12/1011 116/18639 0.103448275862069 1.90719328762918 0.0235071544122953 0.197747207346179 GO:0031625 ubiquitin protein ligase binding 25/1011 302/18639 0.0827814569536424 1.52617564407412 0.0237976184182148 0.19867405679449 GO:0016298 lipase activity 13/1011 130/18639 0.1 1.84362017804154 0.0242816430655129 0.201190756828535 GO:0019199 transmembrane receptor protein kinase activity 9/1011 78/18639 0.115384615384615 2.1272540515864 0.0249944645969032 0.205551492431249 GO:0005085 guanyl-nucleotide exchange factor activity 20/1011 230/18639 0.0869565217391304 1.60314798090569 0.0255899890528794 0.208890132861283 GO:0015370 solute:sodium symporter activity 9/1011 79/18639 0.113924050632911 2.10032678511062 0.0269020227592627 0.217108411427374 GO:0140857 histone H3T45 kinase activity 21/1011 246/18639 0.0853658536585366 1.5738221032062 0.0269907916202815 0.217108411427374 GO:0051059 NF-kappaB binding 5/1011 32/18639 0.15625 2.88065652818991 0.0276654340302969 0.220922523923095 GO:0044389 ubiquitin-like protein ligase binding 26/1011 322/18639 0.0807453416149068 1.488637410841 0.0282075624367823 0.223631178455641 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/1011 22/18639 0.181818181818182 3.35203668734826 0.0288028874915854 0.2257398925572 GO:0004866 endopeptidase inhibitor activity 15/1011 161/18639 0.093167701863354 1.71765855097038 0.0288832348916199 0.2257398925572 GO:0004679 AMP-activated protein kinase activity 21/1011 248/18639 0.0846774193548387 1.56112998947066 0.0291471325896477 0.226198169815435 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/1011 13/18639 0.230769230769231 4.25450810317279 0.0302434635015309 0.233065012438371 GO:0170055 lipid transmembrane transporter activity 7/1011 56/18639 0.125 2.30452522255193 0.0309673272345886 0.236986073698032 GO:0019956 chemokine binding 5/1011 33/18639 0.151515151515152 2.79336390612355 0.0311973040028791 0.237099510421881 GO:0005516 calmodulin binding 18/1011 207/18639 0.0869565217391304 1.60314798090569 0.0329277890041123 0.247751372232398 GO:0004867 serine-type endopeptidase inhibitor activity 10/1011 95/18639 0.105263157894737 1.9406528189911 0.0330485042814541 0.247751372232398 GO:0031267 small GTPase binding 23/1011 283/18639 0.0812720848056537 1.49834855459207 0.0350227837985698 0.260777755040702 GO:0030165 PDZ domain binding 9/1011 83/18639 0.108433734939759 1.99910621715348 0.0355582468175308 0.262987838878651 GO:0051020 GTPase binding 25/1011 315/18639 0.0793650793650794 1.46319061749329 0.0369082368628701 0.264590287388568 GO:0005313 L-glutamate transmembrane transporter activity 3/1011 14/18639 0.214285714285714 3.95061466723188 0.0369754122121956 0.264590287388568 GO:0008191 metalloendopeptidase inhibitor activity 3/1011 14/18639 0.214285714285714 3.95061466723188 0.0369754122121956 0.264590287388568 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 3/1011 14/18639 0.214285714285714 3.95061466723188 0.0369754122121956 0.264590287388568 GO:0046030 inositol trisphosphate phosphatase activity 3/1011 14/18639 0.214285714285714 3.95061466723188 0.0369754122121956 0.264590287388568 GO:0019957 C-C chemokine binding 4/1011 24/18639 0.166666666666667 3.0727002967359 0.0384290491947376 0.270139344805688 GO:0030215 semaphorin receptor binding 4/1011 24/18639 0.166666666666667 3.0727002967359 0.0384290491947376 0.270139344805688 GO:0005154 epidermal growth factor receptor binding 5/1011 35/18639 0.142857142857143 2.63374311148792 0.0390746698537365 0.270139344805688 GO:0004725 protein tyrosine phosphatase activity 10/1011 98/18639 0.102040816326531 1.88124507963423 0.0397037298795787 0.270139344805688 GO:0043495 protein-membrane adaptor activity 6/1011 47/18639 0.127659574468085 2.35355767409559 0.0404380988885813 0.270139344805688 GO:0030414 peptidase inhibitor activity 15/1011 169/18639 0.0887573964497041 1.63634927045107 0.0416841543627892 0.270139344805688 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 20/1011 243/18639 0.0823045267489712 1.51738286258563 0.0420206663325516 0.270139344805688 GO:0042826 histone deacetylase binding 12/1011 127/18639 0.094488188976378 1.74200331783453 0.0431301293459228 0.270139344805688 GO:0016209 antioxidant activity 9/1011 86/18639 0.104651162790698 1.92936995376441 0.043186312262851 0.270139344805688 GO:0004467 long-chain fatty acid-CoA ligase activity 3/1011 15/18639 0.2 3.68724035608309 0.0444042908077255 0.270139344805688 GO:0004953 icosanoid receptor activity 3/1011 15/18639 0.2 3.68724035608309 0.0444042908077255 0.270139344805688 GO:0047372 monoacylglycerol lipase activity 3/1011 15/18639 0.2 3.68724035608309 0.0444042908077255 0.270139344805688 GO:0043130 ubiquitin binding 10/1011 100/18639 0.1 1.84362017804154 0.0446197675346924 0.270139344805688 GO:0004676 3-phosphoinositide-dependent protein kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0004711 ribosomal protein S6 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0035175 histone H3S10 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0035979 histone H2AXS139 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0044022 histone H3S28 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0044023 histone H4S1 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0044024 histone H2AS1 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0044025 histone H2BS14 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0072354 histone H3T3 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0072371 histone H2AS121 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0072518 Rho-dependent protein serine/threonine kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0140823 histone H2BS36 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0140855 histone H3S57 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0140995 histone H2A kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0140997 histone H4 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0140998 histone H2B kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:1990244 histone H2AT120 kinase activity 20/1011 245/18639 0.0816326530612245 1.50499606370738 0.0451072392454566 0.270139344805688 GO:0031490 chromatin DNA binding 12/1011 128/18639 0.09375 1.72839391691395 0.0453500714964177 0.270139344805688 GO:0019905 syntaxin binding 7/1011 61/18639 0.114754098360656 2.11562971250669 0.0462981525093491 0.274304107877972 GO:0004677 DNA-dependent protein kinase activity 20/1011 246/18639 0.0813008130081301 1.49887819352971 0.0467104646990119 0.275267016568508 GO:0035591 signaling adaptor activity 12/1011 129/18639 0.0930232558139535 1.71499551445725 0.047647656738296 0.276095366919654 GO:0031406 carboxylic acid binding 16/1011 187/18639 0.0855614973262032 1.57742902934036 0.0480441994791774 0.276095366919654 GO:0001222 transcription corepressor binding 6/1011 49/18639 0.122448979591837 2.25749409556107 0.0481327328350976 0.276095366919654 GO:0035254 glutamate receptor binding 6/1011 49/18639 0.122448979591837 2.25749409556107 0.0481327328350976 0.276095366919654 GO:0035402 histone H3T11 kinase activity 20/1011 247/18639 0.0809716599190283 1.49280986076238 0.0483542702499939 0.276095366919654 GO:0035403 histone H3T6 kinase activity 20/1011 247/18639 0.0809716599190283 1.49280986076238 0.0483542702499939 0.276095366919654 GO:0004435 phosphatidylinositol phospholipase C activity 4/1011 26/18639 0.153846153846154 2.83633873544853 0.0496788648028241 0.280749276988267 GO:0050681 nuclear androgen receptor binding 4/1011 26/18639 0.153846153846154 2.83633873544853 0.0496788648028241 0.280749276988267 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 9/1011 89/18639 0.101123595505618 1.86433501150268 0.0518413841921014 0.289341875388403 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 9/1011 89/18639 0.101123595505618 1.86433501150268 0.0518413841921014 0.289341875388403 GO:0043177 organic acid binding 16/1011 189/18639 0.0846560846560847 1.56073665865951 0.0519973574495274 0.289341875388403 GO:0005159 insulin-like growth factor receptor binding 3/1011 16/18639 0.1875 3.45678783382789 0.052512137094084 0.289341875388403 GO:0070411 I-SMAD binding 3/1011 16/18639 0.1875 3.45678783382789 0.052512137094084 0.289341875388403 GO:0140793 histone H2AXY142 phosphatase activity 9/1011 90/18639 0.1 1.84362017804154 0.0549613299727564 0.301330276766057 GO:0008266 poly(U) RNA binding 4/1011 27/18639 0.148148148148148 2.73128915265414 0.0559105237954605 0.305016817933651 GO:0042578 phosphoric ester hydrolase activity 27/1011 363/18639 0.0743801652892562 1.37128773573338 0.0604459843857053 0.321556798773803 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/1011 17/18639 0.176470588235294 3.25344737301449 0.0612767039405614 0.321556798773803 GO:0008429 phosphatidylethanolamine binding 3/1011 17/18639 0.176470588235294 3.25344737301449 0.0612767039405614 0.321556798773803 GO:0016018 cyclosporin A binding 3/1011 17/18639 0.176470588235294 3.25344737301449 0.0612767039405614 0.321556798773803 GO:0019198 transmembrane receptor protein phosphatase activity 3/1011 17/18639 0.176470588235294 3.25344737301449 0.0612767039405614 0.321556798773803 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/1011 17/18639 0.176470588235294 3.25344737301449 0.0612767039405614 0.321556798773803 GO:0046965 nuclear retinoid X receptor binding 3/1011 17/18639 0.176470588235294 3.25344737301449 0.0612767039405614 0.321556798773803 GO:1990226 histone methyltransferase binding 3/1011 17/18639 0.176470588235294 3.25344737301449 0.0612767039405614 0.321556798773803 GO:0000149 SNARE binding 10/1011 106/18639 0.0943396226415094 1.73926431890712 0.0617853003579049 0.322689104238916 GO:0036408 histone H3K14 acetyltransferase activity 4/1011 28/18639 0.142857142857143 2.63374311148792 0.0625418316149339 0.323573232111066 GO:0046966 nuclear thyroid hormone receptor binding 4/1011 28/18639 0.142857142857143 2.63374311148792 0.0625418316149339 0.323573232111066 GO:0140662 ATP-dependent protein folding chaperone 5/1011 40/18639 0.125 2.30452522255193 0.0636396797476166 0.327714612532119 GO:0061134 peptidase regulator activity 18/1011 226/18639 0.079646017699115 1.46837005330742 0.0666371996318469 0.341554390671141 GO:0010484 histone H3 acetyltransferase activity 4/1011 29/18639 0.137931034482759 2.54292438350558 0.0695670343443138 0.354920702997379 GO:0016854 racemase and epimerase activity 3/1011 18/18639 0.166666666666667 3.0727002967359 0.0706722016220688 0.357251221043669 GO:0017075 syntaxin-1 binding 3/1011 18/18639 0.166666666666667 3.0727002967359 0.0706722016220688 0.357251221043669 GO:0004620 phospholipase activity 10/1011 109/18639 0.0917431192660551 1.69139465875371 0.0717769964775359 0.361179224284222 GO:0004520 DNA endonuclease activity 5/1011 42/18639 0.119047619047619 2.19478592623993 0.0754235845713499 0.373703427282138 GO:0042056 chemoattractant activity 5/1011 42/18639 0.119047619047619 2.19478592623993 0.0754235845713499 0.373703427282138 GO:0048487 beta-tubulin binding 5/1011 42/18639 0.119047619047619 2.19478592623993 0.0754235845713499 0.373703427282138 GO:0061135 endopeptidase regulator activity 15/1011 184/18639 0.0815217391304348 1.50295123209908 0.0756606648762883 0.373703427282138 GO:0008187 poly-pyrimidine tract binding 4/1011 30/18639 0.133333333333333 2.45816023738872 0.0769788366543062 0.373703427282138 GO:0043995 histone H4K5 acetyltransferase activity 4/1011 30/18639 0.133333333333333 2.45816023738872 0.0769788366543062 0.373703427282138 GO:0043996 histone H4K8 acetyltransferase activity 4/1011 30/18639 0.133333333333333 2.45816023738872 0.0769788366543062 0.373703427282138 GO:0043997 histone H4K12 acetyltransferase activity 4/1011 30/18639 0.133333333333333 2.45816023738872 0.0769788366543062 0.373703427282138 GO:0042800 histone H3K4 methyltransferase activity 3/1011 19/18639 0.157894736842105 2.91097922848665 0.0806699602412322 0.388202166750384 GO:0140036 ubiquitin-modified protein reader activity 3/1011 19/18639 0.157894736842105 2.91097922848665 0.0806699602412322 0.388202166750384 GO:0017147 Wnt-protein binding 4/1011 31/18639 0.129032258064516 2.37886474586006 0.0847685288737512 0.406151820951625 GO:0001664 G protein-coupled receptor binding 22/1011 297/18639 0.0740740740740741 1.36564457632707 0.0862809661152643 0.411608764757668 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 11/1011 128/18639 0.0859375 1.58436109050445 0.0878806719088279 0.417433191566933 GO:0043014 alpha-tubulin binding 5/1011 44/18639 0.113636363636364 2.09502292959266 0.0883036748829074 0.417642273480532 GO:0003823 antigen binding 14/1011 174/18639 0.0804597701149425 1.48337255704492 0.0910898497747139 0.426039827656428 GO:0016004 phospholipase activator activity 3/1011 20/18639 0.15 2.76543026706231 0.0912390193529192 0.426039827656428 GO:0052745 inositol phosphate phosphatase activity 3/1011 20/18639 0.15 2.76543026706231 0.0912390193529192 0.426039827656428 GO:0035401 histone H3Y41 kinase activity 10/1011 115/18639 0.0869565217391304 1.60314798090569 0.0946518871000346 0.43263575800606 GO:0140801 histone H2AXY142 kinase activity 10/1011 115/18639 0.0869565217391304 1.60314798090569 0.0946518871000346 0.43263575800606 GO:0046915 transition metal ion transmembrane transporter activity 5/1011 45/18639 0.111111111111111 2.0484668644906 0.0951452449881852 0.43263575800606 GO:0001094 TFIID-class transcription factor complex binding 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0005031 tumor necrosis factor receptor activity 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0005345 purine nucleobase transmembrane transporter activity 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0005381 iron ion transmembrane transporter activity 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0035256 G protein-coupled glutamate receptor binding 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0042975 peroxisome proliferator activated receptor binding 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0043208 glycosphingolipid binding 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0050308 sugar-phosphatase activity 2/1011 10/18639 0.2 3.68724035608309 0.0990573804889512 0.43263575800606 GO:0015293 symporter activity 12/1011 146/18639 0.0821917808219178 1.51530425592456 0.0993022831602339 0.43263575800606 GO:0004879 nuclear receptor activity 6/1011 59/18639 0.101694915254237 1.87486797766937 0.099325632282698 0.43263575800606 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/1011 59/18639 0.101694915254237 1.87486797766937 0.099325632282698 0.43263575800606 GO:0140416 transcription regulator inhibitor activity 4/1011 33/18639 0.121212121212121 2.23469112489884 0.101440432451182 0.437155076665322 GO:0004180 carboxypeptidase activity 5/1011 46/18639 0.108695652173913 2.00393497613211 0.102248020175989 0.437155076665322 GO:0030291 protein serine/threonine kinase inhibitor activity 5/1011 46/18639 0.108695652173913 2.00393497613211 0.102248020175989 0.437155076665322 GO:0008083 growth factor activity 13/1011 162/18639 0.0802469135802469 1.47944829102099 0.102269597133668 0.437155076665322 GO:0005123 death receptor binding 3/1011 21/18639 0.142857142857143 2.63374311148792 0.102346651342698 0.437155076665322 GO:0004197 cysteine-type endopeptidase activity 8/1011 88/18639 0.0909090909090909 1.67601834367413 0.104356586144929 0.44401914259348 GO:0098531 ligand-modulated transcription factor activity 6/1011 60/18639 0.1 1.84362017804154 0.105594347464639 0.447557580407816 GO:0016791 phosphatase activity 20/1011 273/18639 0.0732600732600733 1.35063749307073 0.106522202299898 0.449760409710682 GO:0140938 histone H3 methyltransferase activity 5/1011 47/18639 0.106382978723404 1.96129806174632 0.109606344138776 0.460415961949006 GO:0030332 cyclin binding 4/1011 34/18639 0.117647058823529 2.16896491534299 0.110299286710107 0.460415961949006 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/1011 34/18639 0.117647058823529 2.16896491534299 0.110299286710107 0.460415961949006 GO:0015377 chloride:monoatomic cation symporter activity 3/1011 22/18639 0.136363636363636 2.5140275155112 0.113958824582347 0.461320704407811 GO:0140035 ubiquitin-like protein reader activity 3/1011 22/18639 0.136363636363636 2.5140275155112 0.113958824582347 0.461320704407811 GO:0032182 ubiquitin-like protein binding 10/1011 120/18639 0.0833333333333333 1.53635014836795 0.116658758373528 0.461320704407811 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0015205 nucleobase transmembrane transporter activity 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0019203 carbohydrate phosphatase activity 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0019215 intermediate filament binding 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0032050 clathrin heavy chain binding 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0032794 GTPase activating protein binding 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0048185 activin binding 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0048407 platelet-derived growth factor binding 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0050786 RAGE receptor binding 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0097493 structural molecule activity conferring elasticity 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1011 11/18639 0.181818181818182 3.35203668734826 0.11686664198712 0.461320704407811 GO:0140693 molecular condensate scaffold activity 5/1011 48/18639 0.104166666666667 1.92043768545994 0.117213972081839 0.461320704407811 GO:0005343 organic acid:sodium symporter activity 4/1011 35/18639 0.114285714285714 2.10699448919033 0.119489559852864 0.466941471481761 GO:0010485 histone H4 acetyltransferase activity 4/1011 35/18639 0.114285714285714 2.10699448919033 0.119489559852864 0.466941471481761 GO:0015108 chloride transmembrane transporter activity 10/1011 121/18639 0.0826446280991736 1.52365303970375 0.121376307497255 0.47068162341395 GO:0060590 ATPase regulator activity 5/1011 49/18639 0.102040816326531 1.88124507963423 0.125064112905333 0.47068162341395 GO:0052689 carboxylic ester hydrolase activity 8/1011 92/18639 0.0869565217391304 1.60314798090569 0.125927415467216 0.47068162341395 GO:0004602 glutathione peroxidase activity 3/1011 23/18639 0.130434782608696 2.40472197135853 0.126040611896881 0.47068162341395 GO:0005158 insulin receptor binding 3/1011 23/18639 0.130434782608696 2.40472197135853 0.126040611896881 0.47068162341395 GO:0005283 amino acid:sodium symporter activity 3/1011 23/18639 0.130434782608696 2.40472197135853 0.126040611896881 0.47068162341395 GO:0016493 C-C chemokine receptor activity 3/1011 23/18639 0.130434782608696 2.40472197135853 0.126040611896881 0.47068162341395 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1011 23/18639 0.130434782608696 2.40472197135853 0.126040611896881 0.47068162341395 GO:0071617 lysophospholipid acyltransferase activity 3/1011 23/18639 0.130434782608696 2.40472197135853 0.126040611896881 0.47068162341395 GO:0099186 structural constituent of postsynapse 3/1011 23/18639 0.130434782608696 2.40472197135853 0.126040611896881 0.47068162341395 GO:0004033 aldo-keto reductase (NADPH) activity 4/1011 36/18639 0.111111111111111 2.0484668644906 0.128997332504677 0.47068162341395 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/1011 36/18639 0.111111111111111 2.0484668644906 0.128997332504677 0.47068162341395 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/1011 36/18639 0.111111111111111 2.0484668644906 0.128997332504677 0.47068162341395 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/1011 36/18639 0.111111111111111 2.0484668644906 0.128997332504677 0.47068162341395 GO:0032813 tumor necrosis factor receptor superfamily binding 5/1011 50/18639 0.1 1.84362017804154 0.133149471743149 0.47068162341395 GO:0070851 growth factor receptor binding 11/1011 139/18639 0.079136690647482 1.45897999701129 0.134340739890062 0.47068162341395 GO:0004859 phospholipase inhibitor activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0004875 complement receptor activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0005025 transforming growth factor beta receptor activity, type I 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0005026 transforming growth factor beta receptor activity, type II 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0005247 voltage-gated chloride channel activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0005436 sodium:phosphate symporter activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0016208 AMP binding 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0016361 activin receptor activity, type I 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0016362 activin receptor activity, type II 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0017002 activin receptor activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0070008 serine-type exopeptidase activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0070410 co-SMAD binding 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0097371 MDM2/MDM4 family protein binding 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0097677 STAT family protein binding 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/1011 12/18639 0.166666666666667 3.0727002967359 0.135395711998387 0.47068162341395 GO:0004806 triacylglycerol lipase activity 3/1011 24/18639 0.125 2.30452522255193 0.138556549425759 0.477154117084957 GO:0005540 hyaluronic acid binding 3/1011 24/18639 0.125 2.30452522255193 0.138556549425759 0.477154117084957 GO:0060229 lipase activator activity 3/1011 24/18639 0.125 2.30452522255193 0.138556549425759 0.477154117084957 GO:0004222 metalloendopeptidase activity 9/1011 110/18639 0.0818181818181818 1.50841650930672 0.142837331972979 0.49036367549602 GO:0030971 receptor tyrosine kinase binding 7/1011 81/18639 0.0864197530864197 1.59325200571491 0.149494486862027 0.50080812206725 GO:0005080 protein kinase C binding 5/1011 52/18639 0.0961538461538462 1.77271170965533 0.14999440070849 0.50080812206725 GO:0003707 nuclear steroid receptor activity 3/1011 25/18639 0.12 2.21234421364985 0.151470950543388 0.50080812206725 GO:0004709 MAP kinase kinase kinase activity 3/1011 25/18639 0.12 2.21234421364985 0.151470950543388 0.50080812206725 GO:0008483 transaminase activity 3/1011 25/18639 0.12 2.21234421364985 0.151470950543388 0.50080812206725 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/1011 25/18639 0.12 2.21234421364985 0.151470950543388 0.50080812206725 GO:0015645 fatty acid ligase activity 3/1011 25/18639 0.12 2.21234421364985 0.151470950543388 0.50080812206725 GO:0042974 nuclear retinoic acid receptor binding 3/1011 25/18639 0.12 2.21234421364985 0.151470950543388 0.50080812206725 GO:0120020 cholesterol transfer activity 3/1011 25/18639 0.12 2.21234421364985 0.151470950543388 0.50080812206725 GO:0120515 fatty acid-CoA ligase activity 3/1011 25/18639 0.12 2.21234421364985 0.151470950543388 0.50080812206725 GO:0004465 lipoprotein lipase activity 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0005035 death receptor activity 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0032396 inhibitory MHC class I receptor activity 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0043560 insulin receptor substrate binding 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0045159 myosin II binding 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0046974 histone H3K9 methyltransferase activity 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0070123 transforming growth factor beta receptor activity, type III 2/1011 13/18639 0.153846153846154 2.83633873544853 0.154514302634179 0.50080812206725 GO:0004721 phosphoprotein phosphatase activity 13/1011 175/18639 0.0742857142857143 1.36954641797372 0.155936840536394 0.503936651821426 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/1011 39/18639 0.102564102564103 1.89089249029902 0.159276730742423 0.51322502128114 GO:0001637 G protein-coupled chemoattractant receptor activity 3/1011 26/18639 0.115384615384615 2.1272540515864 0.164748179118244 0.524718188983541 GO:0004950 chemokine receptor activity 3/1011 26/18639 0.115384615384615 2.1272540515864 0.164748179118244 0.524718188983541 GO:0015145 monosaccharide transmembrane transporter activity 3/1011 26/18639 0.115384615384615 2.1272540515864 0.164748179118244 0.524718188983541 GO:0050750 low-density lipoprotein particle receptor binding 3/1011 26/18639 0.115384615384615 2.1272540515864 0.164748179118244 0.524718188983541 GO:0140463 chromatin-protein adaptor activity 5/1011 54/18639 0.0925925925925926 1.70705572040884 0.167681938172936 0.532523042843156 GO:0015144 carbohydrate transmembrane transporter activity 4/1011 40/18639 0.1 1.84362017804154 0.169903069741845 0.538026387515844 GO:0002039 p53 binding 6/1011 69/18639 0.0869565217391304 1.60314798090569 0.170511361261388 0.538405501747993 GO:0008331 high voltage-gated calcium channel activity 2/1011 14/18639 0.142857142857143 2.63374311148792 0.174104117704509 0.541985134775054 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/1011 14/18639 0.142857142857143 2.63374311148792 0.174104117704509 0.541985134775054 GO:0042043 neurexin family protein binding 2/1011 14/18639 0.142857142857143 2.63374311148792 0.174104117704509 0.541985134775054 GO:0043176 amine binding 2/1011 14/18639 0.142857142857143 2.63374311148792 0.174104117704509 0.541985134775054 GO:0098821 BMP receptor activity 2/1011 14/18639 0.142857142857143 2.63374311148792 0.174104117704509 0.541985134775054 GO:0008374 O-acyltransferase activity 5/1011 55/18639 0.0909090909090909 1.67601834367413 0.176819299848655 0.543632217794154 GO:0004364 glutathione transferase activity 3/1011 27/18639 0.111111111111111 2.0484668644906 0.178352886033592 0.543632217794154 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1011 27/18639 0.111111111111111 2.0484668644906 0.178352886033592 0.543632217794154 GO:0005385 zinc ion transmembrane transporter activity 3/1011 27/18639 0.111111111111111 2.0484668644906 0.178352886033592 0.543632217794154 GO:0016405 CoA-ligase activity 3/1011 27/18639 0.111111111111111 2.0484668644906 0.178352886033592 0.543632217794154 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/1011 27/18639 0.111111111111111 2.0484668644906 0.178352886033592 0.543632217794154 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1011 27/18639 0.111111111111111 2.0484668644906 0.178352886033592 0.543632217794154 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/1011 70/18639 0.0857142857142857 1.58024586689275 0.178579730346174 0.543632217794154 GO:0001530 lipopolysaccharide binding 4/1011 41/18639 0.0975609756097561 1.79865383223565 0.180769016075946 0.547273229988167 GO:0042169 SH2 domain binding 4/1011 41/18639 0.0975609756097561 1.79865383223565 0.180769016075946 0.547273229988167 GO:0015103 inorganic anion transmembrane transporter activity 12/1011 165/18639 0.0727272727272727 1.3408146749393 0.185680255203116 0.55690585110483 GO:0008509 monoatomic anion transmembrane transporter activity 11/1011 149/18639 0.0738255033557047 1.36106187640651 0.186024264706159 0.55690585110483 GO:0030170 pyridoxal phosphate binding 5/1011 56/18639 0.0892857142857143 1.64608944467995 0.186139893881123 0.55690585110483 GO:0004402 histone acetyltransferase activity 4/1011 42/18639 0.0952380952380952 1.75582874099195 0.191858008865904 0.55690585110483 GO:0016859 cis-trans isomerase activity 4/1011 42/18639 0.0952380952380952 1.75582874099195 0.191858008865904 0.55690585110483 GO:0019894 kinesin binding 4/1011 42/18639 0.0952380952380952 1.75582874099195 0.191858008865904 0.55690585110483 GO:0046873 metal ion transmembrane transporter activity 29/1011 450/18639 0.0644444444444444 1.18811078140455 0.192053354606613 0.55690585110483 GO:0019789 SUMO transferase activity 3/1011 28/18639 0.107142857142857 1.97530733361594 0.192250212563832 0.55690585110483 GO:0045499 chemorepellent activity 3/1011 28/18639 0.107142857142857 1.97530733361594 0.192250212563832 0.55690585110483 GO:0051019 mitogen-activated protein kinase binding 3/1011 28/18639 0.107142857142857 1.97530733361594 0.192250212563832 0.55690585110483 GO:0051119 sugar transmembrane transporter activity 3/1011 28/18639 0.107142857142857 1.97530733361594 0.192250212563832 0.55690585110483 GO:0051393 alpha-actinin binding 3/1011 28/18639 0.107142857142857 1.97530733361594 0.192250212563832 0.55690585110483 GO:0141052 histone H3 demethylase activity 3/1011 28/18639 0.107142857142857 1.97530733361594 0.192250212563832 0.55690585110483 GO:0008081 phosphoric diester hydrolase activity 7/1011 87/18639 0.0804597701149425 1.48337255704492 0.192568240566053 0.55690585110483 GO:0000774 adenyl-nucleotide exchange factor activity 2/1011 15/18639 0.133333333333333 2.45816023738872 0.194057937227091 0.55690585110483 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/1011 15/18639 0.133333333333333 2.45816023738872 0.194057937227091 0.55690585110483 GO:0031005 filamin binding 2/1011 15/18639 0.133333333333333 2.45816023738872 0.194057937227091 0.55690585110483 GO:0051371 muscle alpha-actinin binding 2/1011 15/18639 0.133333333333333 2.45816023738872 0.194057937227091 0.55690585110483 GO:0120283 protein serine/threonine kinase binding 2/1011 15/18639 0.133333333333333 2.45816023738872 0.194057937227091 0.55690585110483 GO:0140776 protein-containing complex destabilizing activity 2/1011 15/18639 0.133333333333333 2.45816023738872 0.194057937227091 0.55690585110483 GO:0004601 peroxidase activity 5/1011 57/18639 0.087719298245614 1.61721068249258 0.195634068202242 0.558520059997075 GO:0070279 vitamin B6 binding 5/1011 57/18639 0.087719298245614 1.61721068249258 0.195634068202242 0.558520059997075 GO:0005245 voltage-gated calcium channel activity 4/1011 43/18639 0.0930232558139535 1.71499551445725 0.203153359912826 0.575514145562814 GO:0008375 acetylglucosaminyltransferase activity 4/1011 43/18639 0.0930232558139535 1.71499551445725 0.203153359912826 0.575514145562814 GO:0048156 tau protein binding 4/1011 43/18639 0.0930232558139535 1.71499551445725 0.203153359912826 0.575514145562814 GO:0140789 histone phosphatase activity 10/1011 136/18639 0.0735294117647059 1.35560307208937 0.20384316002917 0.57598759577473 GO:0005416 amino acid:monoatomic cation symporter activity 3/1011 29/18639 0.103448275862069 1.90719328762918 0.206405963896853 0.578777028535196 GO:0051861 glycolipid binding 3/1011 29/18639 0.103448275862069 1.90719328762918 0.206405963896853 0.578777028535196 GO:0099604 ligand-gated calcium channel activity 3/1011 29/18639 0.103448275862069 1.90719328762918 0.206405963896853 0.578777028535196 GO:0004708 MAP kinase kinase activity 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0005149 interleukin-1 receptor binding 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0005521 lamin binding 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0008142 oxysterol binding 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0015562 efflux transmembrane transporter activity 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0055102 lipase inhibitor activity 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0140328 floppase activity 2/1011 16/18639 0.125 2.30452522255193 0.214278765817521 0.57973391645645 GO:0019205 nucleobase-containing compound kinase activity 4/1011 44/18639 0.0909090909090909 1.67601834367413 0.214638328415818 0.57973391645645 GO:0030020 extracellular matrix structural constituent conferring tensile strength 4/1011 44/18639 0.0909090909090909 1.67601834367413 0.214638328415818 0.57973391645645 GO:0030547 signaling receptor inhibitor activity 4/1011 44/18639 0.0909090909090909 1.67601834367413 0.214638328415818 0.57973391645645 GO:0015291 secondary active transmembrane transporter activity 19/1011 287/18639 0.0662020905923345 1.22051510044562 0.215854259891284 0.581592651345221 GO:0001965 G-protein alpha-subunit binding 3/1011 30/18639 0.1 1.84362017804154 0.220786755812691 0.58487260794612 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1011 30/18639 0.1 1.84362017804154 0.220786755812691 0.58487260794612 GO:0016769 transferase activity, transferring nitrogenous groups 3/1011 30/18639 0.1 1.84362017804154 0.220786755812691 0.58487260794612 GO:0031210 phosphatidylcholine binding 3/1011 30/18639 0.1 1.84362017804154 0.220786755812691 0.58487260794612 GO:0032452 histone demethylase activity 3/1011 30/18639 0.1 1.84362017804154 0.220786755812691 0.58487260794612 GO:0048019 receptor antagonist activity 3/1011 30/18639 0.1 1.84362017804154 0.220786755812691 0.58487260794612 GO:0098918 structural constituent of synapse 3/1011 30/18639 0.1 1.84362017804154 0.220786755812691 0.58487260794612 GO:0004715 non-membrane spanning protein tyrosine kinase activity 4/1011 45/18639 0.0888888888888889 1.63877349159248 0.226296190213636 0.596599046926859 GO:0140303 intramembrane lipid transporter activity 4/1011 45/18639 0.0888888888888889 1.63877349159248 0.226296190213636 0.596599046926859 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/1011 17/18639 0.117647058823529 2.16896491534299 0.234679040734449 0.603178770400044 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/1011 17/18639 0.117647058823529 2.16896491534299 0.234679040734449 0.603178770400044 GO:0008484 sulfuric ester hydrolase activity 2/1011 17/18639 0.117647058823529 2.16896491534299 0.234679040734449 0.603178770400044 GO:0015278 intracellularly gated calcium channel activity 2/1011 17/18639 0.117647058823529 2.16896491534299 0.234679040734449 0.603178770400044 GO:0016805 dipeptidase activity 2/1011 17/18639 0.117647058823529 2.16896491534299 0.234679040734449 0.603178770400044 GO:0038191 neuropilin binding 2/1011 17/18639 0.117647058823529 2.16896491534299 0.234679040734449 0.603178770400044 GO:0051787 misfolded protein binding 2/1011 17/18639 0.117647058823529 2.16896491534299 0.234679040734449 0.603178770400044 GO:0070403 NAD+ binding 2/1011 17/18639 0.117647058823529 2.16896491534299 0.234679040734449 0.603178770400044 GO:0008327 methyl-CpG binding 3/1011 31/18639 0.0967741935483871 1.78414855939504 0.235360137270435 0.603178770400044 GO:0016878 acid-thiol ligase activity 3/1011 31/18639 0.0967741935483871 1.78414855939504 0.235360137270435 0.603178770400044 GO:0070325 lipoprotein particle receptor binding 3/1011 31/18639 0.0967741935483871 1.78414855939504 0.235360137270435 0.603178770400044 GO:0140457 protein demethylase activity 3/1011 31/18639 0.0967741935483871 1.78414855939504 0.235360137270435 0.603178770400044 GO:0030276 clathrin binding 4/1011 46/18639 0.0869565217391304 1.60314798090569 0.238110301645793 0.608811026481819 GO:0015179 L-amino acid transmembrane transporter activity 5/1011 62/18639 0.0806451612903226 1.48679046616253 0.245360296368976 0.625895941200491 GO:0061733 protein-lysine-acetyltransferase activity 4/1011 47/18639 0.0851063829787234 1.56903844939706 0.250064158158074 0.630511760038325 GO:0043425 bHLH transcription factor binding 3/1011 32/18639 0.09375 1.72839391691395 0.250094691417233 0.630511760038325 GO:0070717 poly-purine tract binding 3/1011 32/18639 0.09375 1.72839391691395 0.250094691417233 0.630511760038325 GO:0120015 sterol transfer activity 3/1011 32/18639 0.09375 1.72839391691395 0.250094691417233 0.630511760038325 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0004706 JUN kinase kinase kinase activity 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0008308 voltage-gated monoatomic anion channel activity 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0008525 phosphatidylcholine transporter activity 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0032393 MHC class I receptor activity 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0050811 GABA receptor binding 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0070064 proline-rich region binding 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0098641 cadherin binding involved in cell-cell adhesion 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:1990381 ubiquitin-specific protease binding 2/1011 18/18639 0.111111111111111 2.0484668644906 0.255179895623496 0.630511760038325 GO:0030246 carbohydrate binding 18/1011 280/18639 0.0642857142857143 1.18518440016956 0.261508670248437 0.640938791467859 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/1011 48/18639 0.0833333333333333 1.53635014836795 0.262141447801368 0.640938791467859 GO:0032266 phosphatidylinositol-3-phosphate binding 4/1011 48/18639 0.0833333333333333 1.53635014836795 0.262141447801368 0.640938791467859 GO:0038187 pattern recognition receptor activity 4/1011 48/18639 0.0833333333333333 1.53635014836795 0.262141447801368 0.640938791467859 GO:0005200 structural constituent of cytoskeleton 8/1011 112/18639 0.0714285714285714 1.31687155574396 0.262307980900185 0.640938791467859 GO:0016407 acetyltransferase activity 7/1011 96/18639 0.0729166666666667 1.34430637982196 0.26490896147536 0.645862114039483 GO:0004536 DNA nuclease activity 5/1011 64/18639 0.078125 1.44032826409496 0.266114041883051 0.647367934117268 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/1011 19/18639 0.105263157894737 1.9406528189911 0.275710476256704 0.661945413583633 GO:0005520 insulin-like growth factor binding 2/1011 19/18639 0.105263157894737 1.9406528189911 0.275710476256704 0.661945413583633 GO:0008301 DNA binding, bending 2/1011 19/18639 0.105263157894737 1.9406528189911 0.275710476256704 0.661945413583633 GO:0008381 mechanosensitive monoatomic ion channel activity 2/1011 19/18639 0.105263157894737 1.9406528189911 0.275710476256704 0.661945413583633 GO:0050145 nucleoside monophosphate kinase activity 2/1011 19/18639 0.105263157894737 1.9406528189911 0.275710476256704 0.661945413583633 GO:0097001 ceramide binding 2/1011 19/18639 0.105263157894737 1.9406528189911 0.275710476256704 0.661945413583633 GO:0015081 sodium ion transmembrane transporter activity 11/1011 164/18639 0.0670731707317073 1.23657450966201 0.277398180896823 0.664549555104999 GO:0019825 oxygen binding 3/1011 34/18639 0.0882352941176471 1.62672368650724 0.279927294469038 0.669153749468286 GO:0008514 organic anion transmembrane transporter activity 17/1011 269/18639 0.0631970260223048 1.16511312366938 0.292457814364651 0.697479593784892 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 6/1011 83/18639 0.072289156626506 1.33273747810232 0.294742663999414 0.697479593784892 GO:0005254 chloride channel activity 6/1011 83/18639 0.072289156626506 1.33273747810232 0.294742663999414 0.697479593784892 GO:0001972 retinoic acid binding 2/1011 20/18639 0.1 1.84362017804154 0.296207304801569 0.697479593784892 GO:0005326 neurotransmitter transmembrane transporter activity 2/1011 20/18639 0.1 1.84362017804154 0.296207304801569 0.697479593784892 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1011 20/18639 0.1 1.84362017804154 0.296207304801569 0.697479593784892 GO:0043024 ribosomal small subunit binding 2/1011 20/18639 0.1 1.84362017804154 0.296207304801569 0.697479593784892 GO:0042054 histone methyltransferase activity 5/1011 67/18639 0.0746268656716418 1.37583595376235 0.297915525927886 0.700006203779383 GO:0005010 insulin-like growth factor receptor activity 4/1011 51/18639 0.0784313725490196 1.44597661022866 0.29895467178504 0.700953294270455 GO:0051117 ATPase binding 6/1011 84/18639 0.0714285714285714 1.31687155574396 0.30430483771709 0.711982868713872 GO:0005484 SNAP receptor activity 3/1011 36/18639 0.0833333333333333 1.53635014836795 0.310056604778815 0.720848899717836 GO:0016409 palmitoyltransferase activity 3/1011 36/18639 0.0833333333333333 1.53635014836795 0.310056604778815 0.720848899717836 GO:0045505 dynein intermediate chain binding 3/1011 36/18639 0.0833333333333333 1.53635014836795 0.310056604778815 0.720848899717836 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/1011 52/18639 0.0769230769230769 1.41816936772426 0.311368027708086 0.720856232214938 GO:0030159 signaling receptor complex adaptor activity 4/1011 52/18639 0.0769230769230769 1.41816936772426 0.311368027708086 0.720856232214938 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1011 21/18639 0.0952380952380952 1.75582874099195 0.316613689376187 0.72538105133588 GO:0019200 carbohydrate kinase activity 2/1011 21/18639 0.0952380952380952 1.75582874099195 0.316613689376187 0.72538105133588 GO:0036122 BMP binding 2/1011 21/18639 0.0952380952380952 1.75582874099195 0.316613689376187 0.72538105133588 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1011 21/18639 0.0952380952380952 1.75582874099195 0.316613689376187 0.72538105133588 GO:0051428 peptide hormone receptor binding 2/1011 21/18639 0.0952380952380952 1.75582874099195 0.316613689376187 0.72538105133588 GO:0008080 N-acetyltransferase activity 5/1011 69/18639 0.072463768115942 1.33595665075474 0.31944735917836 0.728842629015636 GO:0016279 protein-lysine N-methyltransferase activity 5/1011 69/18639 0.072463768115942 1.33595665075474 0.31944735917836 0.728842629015636 GO:0046943 carboxylic acid transmembrane transporter activity 12/1011 188/18639 0.0638297872340425 1.17677883704779 0.32269863863686 0.729353343404401 GO:0050660 flavin adenine dinucleotide binding 6/1011 86/18639 0.0697674418604651 1.28624663584294 0.323585776904417 0.729353343404401 GO:0034212 protein N-acetyltransferase activity 4/1011 53/18639 0.0754716981132075 1.39141145512569 0.323827683458935 0.729353343404401 GO:0051018 protein kinase A binding 4/1011 53/18639 0.0754716981132075 1.39141145512569 0.323827683458935 0.729353343404401 GO:0140296 general transcription initiation factor binding 4/1011 53/18639 0.0754716981132075 1.39141145512569 0.323827683458935 0.729353343404401 GO:0005342 organic acid transmembrane transporter activity 12/1011 189/18639 0.0634920634920635 1.17055249399463 0.329185595563205 0.729353343404401 GO:0016278 lysine N-methyltransferase activity 5/1011 70/18639 0.0714285714285714 1.31687155574396 0.330283330626989 0.729353343404401 GO:0016887 ATP hydrolysis activity 25/1011 417/18639 0.0599520383693046 1.10528787652371 0.331037491620906 0.729353343404401 GO:0051082 unfolded protein binding 8/1011 121/18639 0.0661157024793388 1.218922431763 0.334405174314869 0.729353343404401 GO:0051287 NAD binding 4/1011 54/18639 0.0740740740740741 1.36564457632707 0.336319343081816 0.729353343404401 GO:0005243 gap junction channel activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0032931 histone H3K56 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0033691 sialic acid binding 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0043992 histone H3K9 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0043993 histone H3K18 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0043994 histone H3K23 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0043999 histone H2AK5 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0044012 histone H2AK9 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0044014 histone H2BK5 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0044015 histone H2BK12 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0044016 histone H3K4 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0044017 histone H3K27 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0044018 histone H3K36 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0046972 histone H4K16 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0050321 tau-protein kinase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0140908 histone H3K122 acetyltransferase activity 2/1011 22/18639 0.0909090909090909 1.67601834367413 0.336879175855572 0.729353343404401 GO:0005109 frizzled binding 3/1011 38/18639 0.0789473684210526 1.45548961424332 0.340274812600726 0.733821611518591 GO:0042887 amide transmembrane transporter activity 3/1011 38/18639 0.0789473684210526 1.45548961424332 0.340274812600726 0.733821611518591 GO:0098632 cell-cell adhesion mediator activity 4/1011 55/18639 0.0727272727272727 1.3408146749393 0.348829150394221 0.750800241668811 GO:0003727 single-stranded RNA binding 6/1011 89/18639 0.0674157303370786 1.24289000766846 0.352796020178529 0.757858117420543 GO:0140658 ATP-dependent chromatin remodeler activity 10/1011 158/18639 0.0632911392405063 1.16684821395034 0.354250195774232 0.759501392496504 GO:0044013 histone H2B acetyltransferase activity 2/1011 23/18639 0.0869565217391304 1.60314798090569 0.356959039089733 0.760868203243492 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/1011 23/18639 0.0869565217391304 1.60314798090569 0.356959039089733 0.760868203243492 GO:0140103 catalytic activity, acting on a glycoprotein 2/1011 23/18639 0.0869565217391304 1.60314798090569 0.356959039089733 0.760868203243492 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 14/1011 229/18639 0.0611353711790393 1.12710403897736 0.361359300149838 0.768760518851586 GO:0030331 nuclear estrogen receptor binding 3/1011 40/18639 0.075 1.38271513353116 0.37039487119814 0.772427081932771 GO:0032451 demethylase activity 3/1011 40/18639 0.075 1.38271513353116 0.37039487119814 0.772427081932771 GO:0050997 quaternary ammonium group binding 3/1011 40/18639 0.075 1.38271513353116 0.37039487119814 0.772427081932771 GO:0071855 neuropeptide receptor binding 3/1011 40/18639 0.075 1.38271513353116 0.37039487119814 0.772427081932771 GO:0071949 FAD binding 3/1011 40/18639 0.075 1.38271513353116 0.37039487119814 0.772427081932771 GO:0031491 nucleosome binding 5/1011 74/18639 0.0675675675675676 1.24568930948753 0.373876914055975 0.772427081932771 GO:0035064 methylated histone binding 5/1011 74/18639 0.0675675675675676 1.24568930948753 0.373876914055975 0.772427081932771 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0004622 lysophospholipase activity 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0005315 phosphate transmembrane transporter activity 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0015149 hexose transmembrane transporter activity 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0043998 histone H2A acetyltransferase activity 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0055056 D-glucose transmembrane transporter activity 2/1011 24/18639 0.0833333333333333 1.53635014836795 0.376813810877366 0.772427081932771 GO:0016757 glycosyltransferase activity 16/1011 267/18639 0.0599250936329588 1.10479111792752 0.377101424754837 0.772427081932771 GO:0001727 lipid kinase activity 3/1011 41/18639 0.0731707317073171 1.34899037417674 0.385365333444629 0.77931066223802 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/1011 41/18639 0.0731707317073171 1.34899037417674 0.385365333444629 0.77931066223802 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1011 41/18639 0.0731707317073171 1.34899037417674 0.385365333444629 0.77931066223802 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/1011 41/18639 0.0731707317073171 1.34899037417674 0.385365333444629 0.77931066223802 GO:0042287 MHC protein binding 3/1011 41/18639 0.0731707317073171 1.34899037417674 0.385365333444629 0.77931066223802 GO:0051213 dioxygenase activity 6/1011 93/18639 0.0645161290322581 1.18943237293003 0.392004146420976 0.77931066223802 GO:0098631 cell adhesion mediator activity 5/1011 76/18639 0.0657894736842105 1.21290801186944 0.395699554748776 0.77931066223802 GO:0140034 methylation-dependent protein binding 5/1011 76/18639 0.0657894736842105 1.21290801186944 0.395699554748776 0.77931066223802 GO:0015271 outward rectifier potassium channel activity 2/1011 25/18639 0.08 1.47489614243323 0.396408842210756 0.77931066223802 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/1011 25/18639 0.08 1.47489614243323 0.396408842210756 0.77931066223802 GO:0017025 TBP-class protein binding 2/1011 25/18639 0.08 1.47489614243323 0.396408842210756 0.77931066223802 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1011 25/18639 0.08 1.47489614243323 0.396408842210756 0.77931066223802 GO:0019707 protein-cysteine S-acyltransferase activity 2/1011 25/18639 0.08 1.47489614243323 0.396408842210756 0.77931066223802 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/1011 25/18639 0.08 1.47489614243323 0.396408842210756 0.77931066223802 GO:0035198 miRNA binding 3/1011 42/18639 0.0714285714285714 1.31687155574396 0.400250512258376 0.77931066223802 GO:0042562 hormone binding 6/1011 94/18639 0.0638297872340425 1.17677883704779 0.401810522774462 0.77931066223802 GO:0003724 RNA helicase activity 5/1011 77/18639 0.0649350649350649 1.19715595976724 0.406587945600257 0.77931066223802 GO:0001098 basal transcription machinery binding 4/1011 60/18639 0.0666666666666667 1.22908011869436 0.4111984211953 0.77931066223802 GO:0001099 basal RNA polymerase II transcription machinery binding 4/1011 60/18639 0.0666666666666667 1.22908011869436 0.4111984211953 0.77931066223802 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/1011 60/18639 0.0666666666666667 1.22908011869436 0.4111984211953 0.77931066223802 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4/1011 60/18639 0.0666666666666667 1.22908011869436 0.4111984211953 0.77931066223802 GO:0008237 metallopeptidase activity 11/1011 184/18639 0.0597826086956522 1.10216423687266 0.414353418901191 0.77931066223802 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/1011 26/18639 0.0769230769230769 1.41816936772426 0.415713897468465 0.77931066223802 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/1011 26/18639 0.0769230769230769 1.41816936772426 0.415713897468465 0.77931066223802 GO:0008143 poly(A) binding 2/1011 26/18639 0.0769230769230769 1.41816936772426 0.415713897468465 0.77931066223802 GO:0030247 polysaccharide binding 2/1011 26/18639 0.0769230769230769 1.41816936772426 0.415713897468465 0.77931066223802 GO:0034237 protein kinase A regulatory subunit binding 2/1011 26/18639 0.0769230769230769 1.41816936772426 0.415713897468465 0.77931066223802 GO:0051139 metal cation:proton antiporter activity 2/1011 26/18639 0.0769230769230769 1.41816936772426 0.415713897468465 0.77931066223802 GO:0052742 phosphatidylinositol kinase activity 2/1011 26/18639 0.0769230769230769 1.41816936772426 0.415713897468465 0.77931066223802 GO:0031072 heat shock protein binding 8/1011 131/18639 0.0610687022900763 1.12587491788797 0.417448173620852 0.77931066223802 GO:1901981 phosphatidylinositol phosphate binding 11/1011 185/18639 0.0594594594594595 1.09620659234903 0.42136610084204 0.77931066223802 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 8/1011 132/18639 0.0606060606060606 1.11734556244942 0.425777753726991 0.77931066223802 GO:0003796 lysozyme activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0004090 carbonyl reductase (NADPH) activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0004382 GDP phosphatase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0005522 profilin binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0005528 FK506 binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0008140 cAMP response element binding protein binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0008239 dipeptidyl-peptidase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0008401 retinoic acid 4-hydroxylase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0015279 store-operated calcium channel activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0030957 Tat protein binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0031434 mitogen-activated protein kinase kinase binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0043121 neurotrophin binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0043295 glutathione binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0043422 protein kinase B binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0051864 histone H3K36 demethylase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0070097 delta-catenin binding 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0140999 histone H3K4 trimethyltransferase activity 1/1011 10/18639 0.1 1.84362017804154 0.427541274003203 0.77931066223802 GO:0008186 ATP-dependent activity, acting on RNA 5/1011 79/18639 0.0632911392405063 1.16684821395034 0.428279668831407 0.77931066223802 GO:0022804 active transmembrane transporter activity 26/1011 457/18639 0.0568927789934354 1.04888675337156 0.429467778905585 0.77931066223802 GO:0017124 SH3 domain binding 7/1011 115/18639 0.0608695652173913 1.12220358663398 0.432950767770886 0.77931066223802 GO:0001671 ATPase activator activity 2/1011 27/18639 0.0740740740740741 1.36564457632707 0.434702778383255 0.77931066223802 GO:0008320 protein transmembrane transporter activity 2/1011 27/18639 0.0740740740740741 1.36564457632707 0.434702778383255 0.77931066223802 GO:0035255 ionotropic glutamate receptor binding 2/1011 27/18639 0.0740740740740741 1.36564457632707 0.434702778383255 0.77931066223802 GO:0000510 H3-H4 histone complex chaperone activity 9/1011 151/18639 0.0596026490066225 1.09884646373337 0.434804433884226 0.77931066223802 GO:0140584 chromatin extrusion motor activity 9/1011 151/18639 0.0596026490066225 1.09884646373337 0.434804433884226 0.77931066223802 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 9/1011 151/18639 0.0596026490066225 1.09884646373337 0.434804433884226 0.77931066223802 GO:0140849 ATP-dependent H2AZ histone chaperone activity 9/1011 151/18639 0.0596026490066225 1.09884646373337 0.434804433884226 0.77931066223802 GO:0008234 cysteine-type peptidase activity 11/1011 187/18639 0.0588235294117647 1.0844824576715 0.435386293306504 0.77931066223802 GO:0046982 protein heterodimerization activity 21/1011 369/18639 0.0569105691056911 1.0492147354708 0.442212990129303 0.77931066223802 GO:0140597 protein carrier chaperone 11/1011 188/18639 0.0585106382978723 1.07871393396048 0.442389480884843 0.77931066223802 GO:0051087 protein-folding chaperone binding 8/1011 134/18639 0.0597014925373134 1.10066876300988 0.442402650865673 0.77931066223802 GO:0015616 DNA translocase activity 9/1011 152/18639 0.0592105263157895 1.09161721068249 0.442598365852035 0.77931066223802 GO:0140674 ATP-dependent histone chaperone activity 9/1011 152/18639 0.0592105263157895 1.09161721068249 0.442598365852035 0.77931066223802 GO:0141110 transporter inhibitor activity 3/1011 45/18639 0.0666666666666667 1.22908011869436 0.444224352881816 0.77931066223802 GO:0005543 phospholipid binding 28/1011 497/18639 0.0563380281690141 1.03865925523467 0.445610841089198 0.77931066223802 GO:0005507 copper ion binding 4/1011 63/18639 0.0634920634920635 1.17055249399463 0.448055960540217 0.77931066223802 GO:0033192 calmodulin-dependent protein phosphatase activity 5/1011 81/18639 0.0617283950617284 1.13803714693922 0.449808790844616 0.77931066223802 GO:0140791 histone H2AXS140 phosphatase activity 5/1011 81/18639 0.0617283950617284 1.13803714693922 0.449808790844616 0.77931066223802 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/1011 81/18639 0.0617283950617284 1.13803714693922 0.449808790844616 0.77931066223802 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/1011 81/18639 0.0617283950617284 1.13803714693922 0.449808790844616 0.77931066223802 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/1011 81/18639 0.0617283950617284 1.13803714693922 0.449808790844616 0.77931066223802 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/1011 81/18639 0.0617283950617284 1.13803714693922 0.449808790844616 0.77931066223802 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/1011 81/18639 0.0617283950617284 1.13803714693922 0.449808790844616 0.77931066223802 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/1011 81/18639 0.0617283950617284 1.13803714693922 0.449808790844616 0.77931066223802 GO:0061775 cohesin loader activity 9/1011 153/18639 0.0588235294117647 1.0844824576715 0.450379392485423 0.77931066223802 GO:0019208 phosphatase regulator activity 7/1011 117/18639 0.0598290598290598 1.10302061934109 0.450794945029794 0.77931066223802 GO:0005242 inward rectifier potassium channel activity 2/1011 28/18639 0.0714285714285714 1.31687155574396 0.453352975753979 0.77931066223802 GO:0046625 sphingolipid binding 2/1011 28/18639 0.0714285714285714 1.31687155574396 0.453352975753979 0.77931066223802 GO:0051959 dynein light intermediate chain binding 2/1011 28/18639 0.0714285714285714 1.31687155574396 0.453352975753979 0.77931066223802 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0001851 complement component C3b binding 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0003953 NAD+ nucleosidase activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0004016 adenylate cyclase activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0008046 axon guidance receptor activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0008199 ferric iron binding 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0008503 benzodiazepine receptor activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0010854 adenylate cyclase regulator activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0019107 myristoyltransferase activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0019206 nucleoside kinase activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0031731 CCR6 chemokine receptor binding 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0034713 type I transforming growth factor beta receptor binding 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0050998 nitric-oxide synthase binding 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0070990 snRNP binding 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:1900750 oligopeptide binding 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:1990948 ubiquitin ligase inhibitor activity 1/1011 11/18639 0.0909090909090909 1.67601834367413 0.458608737204812 0.77931066223802 GO:0044325 transmembrane transporter binding 8/1011 136/18639 0.0588235294117647 1.0844824576715 0.458958820138362 0.77931066223802 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/1011 82/18639 0.0609756097560976 1.12415864514728 0.460494948478161 0.779516794505274 GO:0033549 MAP kinase phosphatase activity 5/1011 82/18639 0.0609756097560976 1.12415864514728 0.460494948478161 0.779516794505274 GO:0005244 voltage-gated monoatomic ion channel activity 10/1011 173/18639 0.0578034682080925 1.06567640349222 0.464604681071452 0.784064867596846 GO:0140030 modification-dependent protein binding 10/1011 173/18639 0.0578034682080925 1.06567640349222 0.464604681071452 0.784064867596846 GO:0004386 helicase activity 9/1011 155/18639 0.0580645161290323 1.07048913563702 0.465891495056192 0.785034292892849 GO:0003785 actin monomer binding 2/1011 29/18639 0.0689655172413793 1.27146219175279 0.471645347002655 0.786476475712616 GO:0016417 S-acyltransferase activity 2/1011 29/18639 0.0689655172413793 1.27146219175279 0.471645347002655 0.786476475712616 GO:0106222 lncRNA binding 2/1011 29/18639 0.0689655172413793 1.27146219175279 0.471645347002655 0.786476475712616 GO:0022832 voltage-gated channel activity 10/1011 175/18639 0.0571428571428571 1.05349724459517 0.479212204625232 0.786476475712616 GO:0017018 myosin phosphatase activity 5/1011 84/18639 0.0595238095238095 1.09739296311997 0.48167802259012 0.786476475712616 GO:0140767 enzyme-substrate adaptor activity 8/1011 139/18639 0.0575539568345324 1.06107636146276 0.483606327685577 0.786476475712616 GO:0005095 GTPase inhibitor activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0005165 neurotrophin receptor binding 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0005527 macrolide binding 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0008504 monoamine transmembrane transporter activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0015132 prostaglandin transmembrane transporter activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0015166 polyol transmembrane transporter activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0016840 carbon-nitrogen lyase activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0035251 UDP-glucosyltransferase activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0045295 gamma-catenin binding 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0140900 chloride:bicarbonate antiporter activity 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:1990459 transferrin receptor binding 1/1011 12/18639 0.0833333333333333 1.53635014836795 0.487991739496305 0.786476475712616 GO:0004722 protein serine/threonine phosphatase activity 6/1011 103/18639 0.058252427184466 1.07395350177177 0.488938124027325 0.786476475712616 GO:0005253 monoatomic anion channel activity 6/1011 103/18639 0.058252427184466 1.07395350177177 0.488938124027325 0.786476475712616 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1011 30/18639 0.0666666666666667 1.22908011869436 0.489563817801939 0.786476475712616 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/1011 122/18639 0.0573770491803279 1.05781485625334 0.494856860177545 0.786476475712616 GO:0016500 protein-hormone receptor activity 4/1011 67/18639 0.0597014925373134 1.10066876300988 0.495980642938487 0.786476475712616 GO:0005004 GPI-linked ephrin receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0005008 hepatocyte growth factor receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0005009 insulin receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0005011 macrophage colony-stimulating factor receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0005020 stem cell factor receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0008288 boss receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0036332 placental growth factor receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0038062 protein tyrosine kinase collagen receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0060175 brain-derived neurotrophic factor receptor activity 3/1011 49/18639 0.0612244897959184 1.12874704778054 0.50072995723092 0.786476475712616 GO:0005319 lipid transporter activity 10/1011 178/18639 0.0561797752808989 1.03574167305705 0.500957505997123 0.786476475712616 GO:0003689 DNA clamp loader activity 9/1011 160/18639 0.05625 1.03703635014837 0.504255273616524 0.786476475712616 GO:0005164 tumor necrosis factor receptor binding 2/1011 31/18639 0.0645161290322581 1.18943237293003 0.507095106114456 0.786476475712616 GO:0005452 solute:inorganic anion antiporter activity 2/1011 31/18639 0.0645161290322581 1.18943237293003 0.507095106114456 0.786476475712616 GO:0016411 acylglycerol O-acyltransferase activity 2/1011 31/18639 0.0645161290322581 1.18943237293003 0.507095106114456 0.786476475712616 GO:0047499 calcium-independent phospholipase A2 activity 2/1011 31/18639 0.0645161290322581 1.18943237293003 0.507095106114456 0.786476475712616 GO:0070273 phosphatidylinositol-4-phosphate binding 2/1011 31/18639 0.0645161290322581 1.18943237293003 0.507095106114456 0.786476475712616 GO:0005548 phospholipid transporter activity 4/1011 68/18639 0.0588235294117647 1.0844824576715 0.507688502149568 0.786476475712616 GO:0030145 manganese ion binding 4/1011 68/18639 0.0588235294117647 1.0844824576715 0.507688502149568 0.786476475712616 GO:0032934 sterol binding 4/1011 68/18639 0.0588235294117647 1.0844824576715 0.507688502149568 0.786476475712616 GO:0020037 heme binding 8/1011 142/18639 0.0563380281690141 1.03865925523467 0.50795512181296 0.786476475712616 GO:0005006 epidermal growth factor receptor activity 3/1011 50/18639 0.06 1.10617210682493 0.514397678225355 0.786476475712616 GO:0005007 fibroblast growth factor receptor activity 3/1011 50/18639 0.06 1.10617210682493 0.514397678225355 0.786476475712616 GO:0005017 platelet-derived growth factor receptor activity 3/1011 50/18639 0.06 1.10617210682493 0.514397678225355 0.786476475712616 GO:0005019 platelet-derived growth factor beta-receptor activity 3/1011 50/18639 0.06 1.10617210682493 0.514397678225355 0.786476475712616 GO:0016853 isomerase activity 10/1011 180/18639 0.0555555555555556 1.0242334322453 0.515318698628731 0.786476475712616 GO:0004535 poly(A)-specific ribonuclease activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0005172 vascular endothelial growth factor receptor binding 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0008253 5'-nucleotidase activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0017154 semaphorin receptor activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0030955 potassium ion binding 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0031994 insulin-like growth factor I binding 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0035673 oligopeptide transmembrane transporter activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0039706 co-receptor binding 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0046975 histone H3K36 methyltransferase activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0061459 L-arginine transmembrane transporter activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0071714 icosanoid transmembrane transporter activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0071837 HMG box domain binding 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0089720 caspase binding 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0140333 glycerophospholipid flippase activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0140666 annealing activity 1/1011 13/18639 0.0769230769230769 1.41816936772426 0.515781525901482 0.786476475712616 GO:0022843 voltage-gated monoatomic cation channel activity 8/1011 143/18639 0.0559440559440559 1.03139590379946 0.515991371996571 0.786476475712616 GO:0016651 oxidoreductase activity, acting on NAD(P)H 5/1011 88/18639 0.0568181818181818 1.04751146479633 0.523123206428316 0.794678795728029 GO:0015106 bicarbonate transmembrane transporter activity 2/1011 32/18639 0.0625 1.15226261127596 0.524228467094271 0.794678795728029 GO:0022884 macromolecule transmembrane transporter activity 2/1011 32/18639 0.0625 1.15226261127596 0.524228467094271 0.794678795728029 GO:0019888 protein phosphatase regulator activity 6/1011 107/18639 0.0560747663551402 1.03380570731301 0.526398325913222 0.794678795728029 GO:0003713 transcription coactivator activity 14/1011 256/18639 0.0546875 1.00822978486647 0.526671001137496 0.794678795728029 GO:0005021 vascular endothelial growth factor receptor activity 3/1011 51/18639 0.0588235294117647 1.0844824576715 0.527862866127874 0.794678795728029 GO:0005030 neurotrophin receptor activity 3/1011 51/18639 0.0588235294117647 1.0844824576715 0.527862866127874 0.794678795728029 GO:0005048 signal sequence binding 3/1011 51/18639 0.0588235294117647 1.0844824576715 0.527862866127874 0.794678795728029 GO:0016830 carbon-carbon lyase activity 3/1011 51/18639 0.0588235294117647 1.0844824576715 0.527862866127874 0.794678795728029 GO:0004175 endopeptidase activity 22/1011 405/18639 0.054320987654321 1.00147268930652 0.528790691765042 0.794910616762743 GO:0140713 histone chaperone activity 9/1011 164/18639 0.0548780487804878 1.01174278063255 0.534353064045893 0.794910616762743 GO:0019239 deaminase activity 2/1011 33/18639 0.0606060606060606 1.11734556244942 0.540955457402686 0.794910616762743 GO:0004065 arylsulfatase activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0004705 JUN kinase activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0005161 platelet-derived growth factor receptor binding 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0005344 oxygen carrier activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0005545 1-phosphatidylinositol binding 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0008494 translation activator activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0032454 histone H3K9 demethylase activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0042813 Wnt receptor activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0061783 peptidoglycan muralytic activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0070742 C2H2 zinc finger domain binding 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0071933 Arp2/3 complex binding 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0098599 palmitoyl hydrolase activity 1/1011 14/18639 0.0714285714285714 1.31687155574396 0.542064403455096 0.794910616762743 GO:0061630 ubiquitin protein ligase activity 19/1011 353/18639 0.0538243626062323 0.992316809710746 0.547744954445627 0.794910616762743 GO:0004864 protein phosphatase inhibitor activity 3/1011 53/18639 0.0566037735849057 1.04355859134427 0.554155050275254 0.794910616762743 GO:0005003 ephrin receptor activity 3/1011 53/18639 0.0566037735849057 1.04355859134427 0.554155050275254 0.794910616762743 GO:0005005 transmembrane-ephrin receptor activity 3/1011 53/18639 0.0566037735849057 1.04355859134427 0.554155050275254 0.794910616762743 GO:0017046 peptide hormone binding 3/1011 53/18639 0.0566037735849057 1.04355859134427 0.554155050275254 0.794910616762743 GO:0038064 collagen receptor activity 3/1011 53/18639 0.0566037735849057 1.04355859134427 0.554155050275254 0.794910616762743 GO:0140097 catalytic activity, acting on DNA 18/1011 336/18639 0.0535714285714286 0.987653666807969 0.556455495688641 0.794910616762743 GO:0008376 acetylgalactosaminyltransferase activity 2/1011 34/18639 0.0588235294117647 1.0844824576715 0.557269717586039 0.794910616762743 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1011 34/18639 0.0588235294117647 1.0844824576715 0.557269717586039 0.794910616762743 GO:0016831 carboxy-lyase activity 2/1011 34/18639 0.0588235294117647 1.0844824576715 0.557269717586039 0.794910616762743 GO:0090482 vitamin transmembrane transporter activity 2/1011 34/18639 0.0588235294117647 1.0844824576715 0.557269717586039 0.794910616762743 GO:0004842 ubiquitin-protein transferase activity 24/1011 449/18639 0.0534521158129176 0.985453992717083 0.559998018063745 0.794910616762743 GO:1902936 phosphatidylinositol bisphosphate binding 6/1011 111/18639 0.0540540540540541 0.996551447590023 0.562695488004591 0.794910616762743 GO:0043178 alcohol binding 5/1011 92/18639 0.0543478260869565 1.00196748806606 0.563068907477789 0.794910616762743 GO:0043539 protein serine/threonine kinase activator activity 4/1011 73/18639 0.0547945205479452 1.01020283728304 0.564250138290248 0.794910616762743 GO:0004559 alpha-mannosidase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0008242 omega peptidase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0008252 nucleotidase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0015250 water channel activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0015929 hexosaminidase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0016846 carbon-sulfur lyase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0030553 cGMP binding 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0031386 protein tag activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0033130 acetylcholine receptor binding 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0034483 heparan sulfate sulfotransferase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0042809 nuclear vitamin D receptor binding 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0045504 dynein heavy chain binding 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0048531 beta-1,3-galactosyltransferase activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0141047 molecular tag activity 1/1011 15/18639 0.0666666666666667 1.22908011869436 0.566922008185668 0.794910616762743 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/1011 54/18639 0.0555555555555556 1.0242334322453 0.566968915404279 0.794910616762743 GO:0005262 calcium channel activity 7/1011 131/18639 0.0534351145038168 0.985140553151969 0.57099784354556 0.799542088420848 GO:0004623 phospholipase A2 activity 2/1011 35/18639 0.0571428571428571 1.05349724459517 0.573166771252508 0.800544717262691 GO:0140566 histone reader activity 2/1011 35/18639 0.0571428571428571 1.05349724459517 0.573166771252508 0.800544717262691 GO:0035091 phosphatidylinositol binding 15/1011 284/18639 0.0528169014084507 0.973743051782505 0.58012359295157 0.805283673193617 GO:0016410 N-acyltransferase activity 5/1011 94/18639 0.0531914893617021 0.980649030873161 0.582394000297779 0.805283673193617 GO:0046906 tetrapyrrole binding 8/1011 152/18639 0.0526315789473684 0.970326409495549 0.586015952463636 0.805283673193617 GO:0000993 RNA polymerase II complex binding 2/1011 36/18639 0.0555555555555556 1.0242334322453 0.588643839868607 0.805283673193617 GO:0004190 aspartic-type endopeptidase activity 2/1011 36/18639 0.0555555555555556 1.0242334322453 0.588643839868607 0.805283673193617 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1011 36/18639 0.0555555555555556 1.0242334322453 0.588643839868607 0.805283673193617 GO:0000062 fatty-acyl-CoA binding 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0004707 MAP kinase activity 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0015378 sodium:chloride symporter activity 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0015923 mannosidase activity 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0022841 potassium ion leak channel activity 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0022858 alanine transmembrane transporter activity 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0043023 ribosomal large subunit binding 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0140327 flippase activity 1/1011 16/18639 0.0625 1.15226261127596 0.590431557676877 0.805283673193617 GO:0008094 ATP-dependent activity, acting on DNA 11/1011 210/18639 0.0523809523809524 0.96570580754557 0.591186762366366 0.805283673193617 GO:0008276 protein methyltransferase activity 5/1011 95/18639 0.0526315789473684 0.970326409495549 0.591882193019032 0.805283673193617 GO:0019212 phosphatase inhibitor activity 3/1011 56/18639 0.0535714285714286 0.987653666807969 0.591905422220354 0.805283673193617 GO:0017022 myosin binding 4/1011 76/18639 0.0526315789473684 0.970326409495549 0.596415740822285 0.810419416012525 GO:0015297 antiporter activity 7/1011 135/18639 0.0518518518518519 0.955951203428948 0.60306890872039 0.811488018226357 GO:0019213 deacetylase activity 2/1011 37/18639 0.0540540540540541 0.996551447590023 0.60369967207438 0.811488018226357 GO:0022829 wide pore channel activity 2/1011 37/18639 0.0540540540540541 0.996551447590023 0.60369967207438 0.811488018226357 GO:0030280 structural constituent of skin epidermis 2/1011 37/18639 0.0540540540540541 0.996551447590023 0.60369967207438 0.811488018226357 GO:0070001 aspartic-type peptidase activity 2/1011 37/18639 0.0540540540540541 0.996551447590023 0.60369967207438 0.811488018226357 GO:0016504 peptidase activator activity 3/1011 57/18639 0.0526315789473684 0.970326409495549 0.60401960698031 0.811488018226357 GO:0019787 ubiquitin-like protein transferase activity 25/1011 479/18639 0.0521920668058455 0.96222347496949 0.608803359280471 0.811488018226357 GO:0016779 nucleotidyltransferase activity 7/1011 136/18639 0.0514705882352941 0.948922150462559 0.610888836007787 0.811488018226357 GO:0008236 serine-type peptidase activity 10/1011 194/18639 0.0515463917525773 0.950319679402857 0.611477035095214 0.811488018226357 GO:0015631 tubulin binding 20/1011 385/18639 0.051948051948052 0.957724767813789 0.61205867811399 0.811488018226357 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0004550 nucleoside diphosphate kinase activity 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0008569 minus-end-directed microtubule motor activity 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0009881 photoreceptor activity 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0017110 nucleoside diphosphate phosphatase activity 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0031489 myosin V binding 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0045125 bioactive lipid receptor activity 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0045236 CXCR chemokine receptor binding 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0048038 quinone binding 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:1901567 fatty acid derivative binding 1/1011 17/18639 0.0588235294117647 1.0844824576715 0.612666089985779 0.811488018226357 GO:0061980 regulatory RNA binding 3/1011 58/18639 0.0517241379310345 0.953596643814591 0.615893264703203 0.811908418543237 GO:0000146 microfilament motor activity 2/1011 38/18639 0.0526315789473684 0.970326409495549 0.618334386489583 0.811908418543237 GO:0005501 retinoid binding 2/1011 38/18639 0.0526315789473684 0.970326409495549 0.618334386489583 0.811908418543237 GO:0019840 isoprenoid binding 2/1011 38/18639 0.0526315789473684 0.970326409495549 0.618334386489583 0.811908418543237 GO:0042162 telomeric DNA binding 2/1011 38/18639 0.0526315789473684 0.970326409495549 0.618334386489583 0.811908418543237 GO:0043531 ADP binding 2/1011 38/18639 0.0526315789473684 0.970326409495549 0.618334386489583 0.811908418543237 GO:0005249 voltage-gated potassium channel activity 5/1011 98/18639 0.0510204081632653 0.940622539817114 0.619614319414575 0.811908418543237 GO:0008170 N-methyltransferase activity 5/1011 98/18639 0.0510204081632653 0.940622539817114 0.619614319414575 0.811908418543237 GO:0042626 ATPase-coupled transmembrane transporter activity 5/1011 98/18639 0.0510204081632653 0.940622539817114 0.619614319414575 0.811908418543237 GO:0043021 ribonucleoprotein complex binding 9/1011 177/18639 0.0508474576271186 0.937433988834683 0.626826246059488 0.813906233098918 GO:0001786 phosphatidylserine binding 3/1011 59/18639 0.0508474576271186 0.937433988834683 0.62752384322767 0.813906233098918 GO:0015459 potassium channel regulator activity 3/1011 59/18639 0.0508474576271186 0.937433988834683 0.62752384322767 0.813906233098918 GO:0031593 polyubiquitin modification-dependent protein binding 3/1011 59/18639 0.0508474576271186 0.937433988834683 0.62752384322767 0.813906233098918 GO:0036002 pre-mRNA binding 3/1011 59/18639 0.0508474576271186 0.937433988834683 0.62752384322767 0.813906233098918 GO:0070063 RNA polymerase binding 3/1011 59/18639 0.0508474576271186 0.937433988834683 0.62752384322767 0.813906233098918 GO:0070888 E-box binding 3/1011 59/18639 0.0508474576271186 0.937433988834683 0.62752384322767 0.813906233098918 GO:0000217 DNA secondary structure binding 2/1011 39/18639 0.0512820512820513 0.945446245149509 0.632549327051781 0.813906233098918 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/1011 39/18639 0.0512820512820513 0.945446245149509 0.632549327051781 0.813906233098918 GO:0000400 four-way junction DNA binding 1/1011 18/18639 0.0555555555555556 1.0242334322453 0.633694689654149 0.813906233098918 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1011 18/18639 0.0555555555555556 1.0242334322453 0.633694689654149 0.813906233098918 GO:0005372 water transmembrane transporter activity 1/1011 18/18639 0.0555555555555556 1.0242334322453 0.633694689654149 0.813906233098918 GO:0015373 monoatomic anion:sodium symporter activity 1/1011 18/18639 0.0555555555555556 1.0242334322453 0.633694689654149 0.813906233098918 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1011 18/18639 0.0555555555555556 1.0242334322453 0.633694689654149 0.813906233098918 GO:0017128 phospholipid scramblase activity 1/1011 18/18639 0.0555555555555556 1.0242334322453 0.633694689654149 0.813906233098918 GO:0022851 GABA-gated chloride ion channel activity 1/1011 18/18639 0.0555555555555556 1.0242334322453 0.633694689654149 0.813906233098918 GO:0035615 clathrin adaptor activity 1/1011 18/18639 0.0555555555555556 1.0242334322453 0.633694689654149 0.813906233098918 GO:0017171 serine hydrolase activity 10/1011 198/18639 0.0505050505050505 0.931121302041183 0.637170185956449 0.817417398048902 GO:0061659 ubiquitin-like protein ligase activity 19/1011 372/18639 0.0510752688172043 0.941633961902939 0.640322252086162 0.820153169792973 GO:0015079 potassium ion transmembrane transporter activity 8/1011 160/18639 0.05 0.921810089020772 0.643925501486456 0.820153169792973 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/1011 40/18639 0.05 0.921810089020772 0.646346929991446 0.820153169792973 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/1011 61/18639 0.0491803278688525 0.906698448217152 0.650048523989849 0.820153169792973 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 9/1011 181/18639 0.0497237569060773 0.916717215600767 0.653241144069543 0.820153169792973 GO:0004890 GABA-A receptor activity 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0008574 plus-end-directed microtubule motor activity 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0022840 leak channel activity 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0022842 narrow pore channel activity 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0030506 ankyrin binding 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0031420 alkali metal ion binding 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0034987 immunoglobulin receptor binding 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0042834 peptidoglycan binding 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0046527 glucosyltransferase activity 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0046624 sphingolipid transporter activity 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0120227 acyl-CoA binding 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0141147 intracellularly calcium-gated channel activity 1/1011 19/18639 0.0526315789473684 0.970326409495549 0.653582701509562 0.820153169792973 GO:0008238 exopeptidase activity 5/1011 102/18639 0.0490196078431373 0.903735381392913 0.654794372943407 0.820153169792973 GO:0015171 amino acid transmembrane transporter activity 5/1011 102/18639 0.0490196078431373 0.903735381392913 0.654794372943407 0.820153169792973 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/1011 122/18639 0.0491803278688525 0.906698448217152 0.654931750832864 0.820153169792973 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/1011 41/18639 0.0487804878048781 0.899326916117826 0.659730601609232 0.823355745156708 GO:0140318 protein transporter activity 2/1011 41/18639 0.0487804878048781 0.899326916117826 0.659730601609232 0.823355745156708 GO:0140828 metal cation:monoatomic cation antiporter activity 2/1011 41/18639 0.0487804878048781 0.899326916117826 0.659730601609232 0.823355745156708 GO:0003730 mRNA 3'-UTR binding 13/1011 262/18639 0.049618320610687 0.914773370783972 0.669404464286629 0.828291034521347 GO:1901682 sulfur compound transmembrane transporter activity 3/1011 63/18639 0.0476190476190476 0.877914370495973 0.671584603461877 0.828291034521347 GO:0001614 purinergic nucleotide receptor activity 1/1011 20/18639 0.05 0.921810089020772 0.672391932915246 0.828291034521347 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1011 20/18639 0.05 0.921810089020772 0.672391932915246 0.828291034521347 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/1011 20/18639 0.05 0.921810089020772 0.672391932915246 0.828291034521347 GO:0010851 cyclase regulator activity 1/1011 20/18639 0.05 0.921810089020772 0.672391932915246 0.828291034521347 GO:0015095 magnesium ion transmembrane transporter activity 1/1011 20/18639 0.05 0.921810089020772 0.672391932915246 0.828291034521347 GO:0016502 nucleotide receptor activity 1/1011 20/18639 0.05 0.921810089020772 0.672391932915246 0.828291034521347 GO:0031418 L-ascorbic acid binding 1/1011 20/18639 0.05 0.921810089020772 0.672391932915246 0.828291034521347 GO:0042288 MHC class I protein binding 1/1011 20/18639 0.05 0.921810089020772 0.672391932915246 0.828291034521347 GO:0031492 nucleosomal DNA binding 2/1011 42/18639 0.0476190476190476 0.877914370495973 0.672704606076775 0.828291034521347 GO:0043175 RNA polymerase core enzyme binding 2/1011 42/18639 0.0476190476190476 0.877914370495973 0.672704606076775 0.828291034521347 GO:0008194 UDP-glycosyltransferase activity 7/1011 145/18639 0.0482758620689655 0.890023534226952 0.677350775573588 0.832413590178851 GO:0016755 aminoacyltransferase activity 25/1011 496/18639 0.0504032258064516 0.929244041351584 0.677563512151025 0.832413590178851 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1011 43/18639 0.0465116279069767 0.857497757228625 0.685273962534944 0.834314589208081 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0001846 opsonin binding 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0005248 voltage-gated sodium channel activity 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0008373 sialyltransferase activity 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0009975 cyclase activity 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0015174 basic amino acid transmembrane transporter activity 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0035613 RNA stem-loop binding 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0051010 microtubule plus-end binding 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0061891 calcium ion sensor activity 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0070182 DNA polymerase binding 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0140312 cargo adaptor activity 1/1011 21/18639 0.0476190476190476 0.877914370495973 0.690180845092199 0.834314589208081 GO:0015085 calcium ion transmembrane transporter activity 7/1011 147/18639 0.0476190476190476 0.877914370495973 0.691107270299389 0.834314589208081 GO:0120013 lipid transfer activity 3/1011 65/18639 0.0461538461538462 0.850901620634558 0.692130951321271 0.834314589208081 GO:0004519 endonuclease activity 6/1011 127/18639 0.047244094488189 0.871001658917264 0.692636477947481 0.834314589208081 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/1011 86/18639 0.0465116279069767 0.857497757228625 0.69273852007749 0.834314589208081 GO:0042393 histone binding 12/1011 247/18639 0.048582995951417 0.89568591645743 0.693797741209551 0.834678068573062 GO:0001046 core promoter sequence-specific DNA binding 2/1011 44/18639 0.0454545454545455 0.838009171837065 0.697444350812612 0.835417037603802 GO:0003954 NADH dehydrogenase activity 2/1011 44/18639 0.0454545454545455 0.838009171837065 0.697444350812612 0.835417037603802 GO:0016248 channel inhibitor activity 2/1011 44/18639 0.0454545454545455 0.838009171837065 0.697444350812612 0.835417037603802 GO:0016790 thiolester hydrolase activity 2/1011 44/18639 0.0454545454545455 0.838009171837065 0.697444350812612 0.835417037603802 GO:0140104 molecular carrier activity 12/1011 249/18639 0.0481927710843374 0.888491652068214 0.70420689925348 0.837762598905399 GO:0004407 histone deacetylase activity 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0008093 cytoskeletal anchor activity 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0008970 phospholipase A1 activity 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0033558 protein lysine deacetylase activity 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0034062 5'-3' RNA polymerase activity 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0097747 RNA polymerase activity 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0140517 protein-RNA adaptor activity 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0140784 metal ion sensor activity 1/1011 22/18639 0.0454545454545455 0.838009171837065 0.707004734103467 0.837762598905399 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/1011 67/18639 0.0447761194029851 0.825501572257407 0.71169330292678 0.842412481015373 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6/1011 130/18639 0.0461538461538462 0.850901620634558 0.713902662629792 0.844120959461406 GO:0003777 microtubule motor activity 3/1011 68/18639 0.0441176470588235 0.813361843253622 0.721108909116498 0.84750353624321 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/1011 23/18639 0.0434782608695652 0.801573990452845 0.722915902058637 0.84750353624321 GO:0005212 structural constituent of eye lens 1/1011 23/18639 0.0434782608695652 0.801573990452845 0.722915902058637 0.84750353624321 GO:0016849 phosphorus-oxygen lyase activity 1/1011 23/18639 0.0434782608695652 0.801573990452845 0.722915902058637 0.84750353624321 GO:0016917 GABA receptor activity 1/1011 23/18639 0.0434782608695652 0.801573990452845 0.722915902058637 0.84750353624321 GO:0017134 fibroblast growth factor binding 1/1011 23/18639 0.0434782608695652 0.801573990452845 0.722915902058637 0.84750353624321 GO:0043274 phospholipase binding 1/1011 23/18639 0.0434782608695652 0.801573990452845 0.722915902058637 0.84750353624321 GO:0070577 lysine-acetylated histone binding 1/1011 23/18639 0.0434782608695652 0.801573990452845 0.722915902058637 0.84750353624321 GO:0001784 phosphotyrosine residue binding 2/1011 47/18639 0.0425531914893617 0.784519224698529 0.731626654309479 0.853177325977827 GO:0061749 forked DNA-dependent helicase activity 2/1011 47/18639 0.0425531914893617 0.784519224698529 0.731626654309479 0.853177325977827 GO:0099095 ligand-gated monoatomic anion channel activity 2/1011 47/18639 0.0425531914893617 0.784519224698529 0.731626654309479 0.853177325977827 GO:0140359 ABC-type transporter activity 2/1011 47/18639 0.0425531914893617 0.784519224698529 0.731626654309479 0.853177325977827 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/1011 47/18639 0.0425531914893617 0.784519224698529 0.731626654309479 0.853177325977827 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/1011 91/18639 0.043956043956044 0.810382495842437 0.73430169769198 0.854239630894226 GO:0072341 modified amino acid binding 4/1011 91/18639 0.043956043956044 0.810382495842437 0.73430169769198 0.854239630894226 GO:0015295 solute:proton symporter activity 1/1011 24/18639 0.0416666666666667 0.768175074183976 0.737963819066518 0.854239630894226 GO:0030552 cAMP binding 1/1011 24/18639 0.0416666666666667 0.768175074183976 0.737963819066518 0.854239630894226 GO:0035035 histone acetyltransferase binding 1/1011 24/18639 0.0416666666666667 0.768175074183976 0.737963819066518 0.854239630894226 GO:0050699 WW domain binding 1/1011 24/18639 0.0416666666666667 0.768175074183976 0.737963819066518 0.854239630894226 GO:0140033 acetylation-dependent protein binding 1/1011 24/18639 0.0416666666666667 0.768175074183976 0.737963819066518 0.854239630894226 GO:0009378 four-way junction helicase activity 2/1011 48/18639 0.0416666666666667 0.768175074183976 0.74226831334157 0.855627281697082 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/1011 48/18639 0.0416666666666667 0.768175074183976 0.74226831334157 0.855627281697082 GO:0036121 double-stranded DNA helicase activity 2/1011 48/18639 0.0416666666666667 0.768175074183976 0.74226831334157 0.855627281697082 GO:0043138 3'-5' DNA helicase activity 2/1011 48/18639 0.0416666666666667 0.768175074183976 0.74226831334157 0.855627281697082 GO:0004252 serine-type endopeptidase activity 8/1011 176/18639 0.0454545454545455 0.838009171837065 0.744631576459713 0.857454542589972 GO:0051219 phosphoprotein binding 4/1011 93/18639 0.043010752688172 0.792954915286685 0.749693838255557 0.861662364482255 GO:0001848 complement binding 1/1011 25/18639 0.04 0.737448071216617 0.752195276435508 0.861662364482255 GO:0008139 nuclear localization sequence binding 1/1011 25/18639 0.04 0.737448071216617 0.752195276435508 0.861662364482255 GO:0015662 P-type ion transporter activity 1/1011 25/18639 0.04 0.737448071216617 0.752195276435508 0.861662364482255 GO:0140358 P-type transmembrane transporter activity 1/1011 25/18639 0.04 0.737448071216617 0.752195276435508 0.861662364482255 GO:0015605 organophosphate ester transmembrane transporter activity 2/1011 50/18639 0.04 0.737448071216617 0.762469410554331 0.872524704497272 GO:0008198 ferrous iron binding 1/1011 26/18639 0.0384615384615385 0.709084683862132 0.76565453159419 0.874353672349012 GO:0030507 spectrin binding 1/1011 26/18639 0.0384615384615385 0.709084683862132 0.76565453159419 0.874353672349012 GO:0016597 amino acid binding 2/1011 51/18639 0.0392156862745098 0.722988305114331 0.77204518787786 0.879577493224289 GO:0030544 Hsp70 protein binding 2/1011 51/18639 0.0392156862745098 0.722988305114331 0.77204518787786 0.879577493224289 GO:0048029 monosaccharide binding 3/1011 74/18639 0.0405405405405405 0.747413585692517 0.772623424175238 0.879577493224289 GO:0022853 active monoatomic ion transmembrane transporter activity 5/1011 118/18639 0.0423728813559322 0.781194990695569 0.773608943514485 0.879790563212552 GO:0008395 steroid hydroxylase activity 1/1011 27/18639 0.037037037037037 0.682822288163534 0.778383445179226 0.883397071665815 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/1011 27/18639 0.037037037037037 0.682822288163534 0.778383445179226 0.883397071665815 GO:0003725 double-stranded RNA binding 3/1011 75/18639 0.04 0.737448071216617 0.780405578056334 0.884780809689382 GO:0005246 calcium channel regulator activity 2/1011 53/18639 0.0377358490566038 0.695705727562846 0.790189239857089 0.888821035720684 GO:0005544 calcium-dependent phospholipid binding 2/1011 53/18639 0.0377358490566038 0.695705727562846 0.790189239857089 0.888821035720684 GO:0016860 intramolecular oxidoreductase activity 2/1011 53/18639 0.0377358490566038 0.695705727562846 0.790189239857089 0.888821035720684 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1011 53/18639 0.0377358490566038 0.695705727562846 0.790189239857089 0.888821035720684 GO:0046875 ephrin receptor binding 1/1011 28/18639 0.0357142857142857 0.65843577787198 0.790421610713494 0.888821035720684 GO:0050698 proteoglycan sulfotransferase activity 1/1011 28/18639 0.0357142857142857 0.65843577787198 0.790421610713494 0.888821035720684 GO:0051537 2 iron, 2 sulfur cluster binding 1/1011 28/18639 0.0357142857142857 0.65843577787198 0.790421610713494 0.888821035720684 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/1011 28/18639 0.0357142857142857 0.65843577787198 0.790421610713494 0.888821035720684 GO:0015485 cholesterol binding 2/1011 54/18639 0.037037037037037 0.682822288163534 0.798774636951428 0.895876125372829 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/1011 54/18639 0.037037037037037 0.682822288163534 0.798774636951428 0.895876125372829 GO:0004181 metallocarboxypeptidase activity 1/1011 29/18639 0.0344827586206897 0.635731095876394 0.801806477274595 0.895876125372829 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/1011 29/18639 0.0344827586206897 0.635731095876394 0.801806477274595 0.895876125372829 GO:0035250 UDP-galactosyltransferase activity 1/1011 29/18639 0.0344827586206897 0.635731095876394 0.801806477274595 0.895876125372829 GO:0097472 cyclin-dependent protein kinase activity 1/1011 29/18639 0.0344827586206897 0.635731095876394 0.801806477274595 0.895876125372829 GO:0015399 primary active transmembrane transporter activity 7/1011 166/18639 0.0421686746987952 0.777430195559687 0.802386330075301 0.895876125372829 GO:0005267 potassium channel activity 5/1011 124/18639 0.0403225806451613 0.743395233081267 0.80915282225021 0.902516609432926 GO:0031624 ubiquitin conjugating enzyme binding 1/1011 30/18639 0.0333333333333333 0.614540059347181 0.812573465532273 0.903588253296231 GO:0033612 receptor serine/threonine kinase binding 1/1011 30/18639 0.0333333333333333 0.614540059347181 0.812573465532273 0.903588253296231 GO:0070566 adenylyltransferase activity 1/1011 30/18639 0.0333333333333333 0.614540059347181 0.812573465532273 0.903588253296231 GO:0141108 transporter regulator activity 7/1011 170/18639 0.0411764705882353 0.759137720370047 0.821391018163574 0.90940541366016 GO:0015101 organic cation transmembrane transporter activity 3/1011 81/18639 0.037037037037037 0.682822288163534 0.822588947832257 0.90940541366016 GO:0008017 microtubule binding 12/1011 276/18639 0.0434782608695652 0.801573990452845 0.822616008174828 0.90940541366016 GO:0005184 neuropeptide hormone activity 1/1011 31/18639 0.032258064516129 0.594716186465014 0.822756077512867 0.90940541366016 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1011 31/18639 0.032258064516129 0.594716186465014 0.822756077512867 0.90940541366016 GO:0072349 modified amino acid transmembrane transporter activity 1/1011 31/18639 0.032258064516129 0.594716186465014 0.822756077512867 0.90940541366016 GO:0022836 gated channel activity 14/1011 318/18639 0.0440251572327044 0.811656682156654 0.824592244348591 0.910521696665478 GO:0019842 vitamin binding 6/1011 150/18639 0.04 0.737448071216617 0.829563303641326 0.912725743754642 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/1011 58/18639 0.0344827586206897 0.635731095876394 0.830073422843069 0.912725743754642 GO:0017116 single-stranded DNA helicase activity 2/1011 58/18639 0.0344827586206897 0.635731095876394 0.830073422843069 0.912725743754642 GO:0008378 galactosyltransferase activity 1/1011 32/18639 0.03125 0.576131305637982 0.832386000429596 0.912725743754642 GO:0042910 xenobiotic transmembrane transporter activity 1/1011 32/18639 0.03125 0.576131305637982 0.832386000429596 0.912725743754642 GO:0047498 calcium-dependent phospholipase A2 activity 1/1011 32/18639 0.03125 0.576131305637982 0.832386000429596 0.912725743754642 GO:0160041 neuropeptide activity 1/1011 32/18639 0.03125 0.576131305637982 0.832386000429596 0.912725743754642 GO:0045309 protein phosphorylated amino acid binding 2/1011 59/18639 0.0338983050847458 0.624955992556455 0.837180425636592 0.917070406611853 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/1011 130/18639 0.0384615384615385 0.709084683862132 0.840106652916713 0.919054025568785 GO:0180051 translation factor activity 3/1011 84/18639 0.0357142857142857 0.65843577787198 0.840956770921734 0.919054025568785 GO:0042923 neuropeptide binding 1/1011 33/18639 0.0303030303030303 0.55867278122471 0.841493204899187 0.919054025568785 GO:0003774 cytoskeletal motor activity 6/1011 153/18639 0.0392156862745098 0.722988305114331 0.843174447305839 0.919975963425708 GO:0005496 steroid binding 4/1011 108/18639 0.037037037037037 0.682822288163534 0.84400698640961 0.919975963425708 GO:0008175 tRNA methyltransferase activity 1/1011 34/18639 0.0294117647058824 0.542241228835748 0.85010603784807 0.923882498726404 GO:0015035 protein-disulfide reductase activity 1/1011 34/18639 0.0294117647058824 0.542241228835748 0.85010603784807 0.923882498726404 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1011 34/18639 0.0294117647058824 0.542241228835748 0.85010603784807 0.923882498726404 GO:0016829 lyase activity 8/1011 200/18639 0.04 0.737448071216617 0.855381093336483 0.928699472765324 GO:0000175 3'-5'-RNA exonuclease activity 1/1011 35/18639 0.0285714285714286 0.526748622297584 0.858251310394998 0.929983229159576 GO:0061631 ubiquitin conjugating enzyme activity 1/1011 35/18639 0.0285714285714286 0.526748622297584 0.858251310394998 0.929983229159576 GO:0043022 ribosome binding 4/1011 112/18639 0.0357142857142857 0.65843577787198 0.863425480859872 0.93373945972757 GO:0003924 GTPase activity 14/1011 331/18639 0.0422960725075529 0.779778927268326 0.86435381577861 0.93373945972757 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1011 36/18639 0.0277777777777778 0.512116716122651 0.865954380981467 0.93373945972757 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/1011 36/18639 0.0277777777777778 0.512116716122651 0.865954380981467 0.93373945972757 GO:0055106 ubiquitin-protein transferase regulator activity 1/1011 36/18639 0.0277777777777778 0.512116716122651 0.865954380981467 0.93373945972757 GO:0099094 ligand-gated monoatomic cation channel activity 5/1011 136/18639 0.0367647058823529 0.677801536044685 0.866812341009897 0.933750928438814 GO:0030551 cyclic nucleotide binding 1/1011 37/18639 0.027027027027027 0.498275723795012 0.873239234006664 0.939212467385129 GO:0019843 rRNA binding 2/1011 65/18639 0.0307692307692308 0.567267747089706 0.874439193772361 0.939212467385129 GO:0160215 deacylase activity 2/1011 65/18639 0.0307692307692308 0.567267747089706 0.874439193772361 0.939212467385129 GO:0008235 metalloexopeptidase activity 2/1011 66/18639 0.0303030303030303 0.55867278122471 0.879826839605672 0.942302555456116 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/1011 38/18639 0.0263157894736842 0.485163204747774 0.880128554209828 0.942302555456116 GO:0015078 proton transmembrane transporter activity 7/1011 185/18639 0.0378378378378378 0.697586013313016 0.880160010613168 0.942302555456116 GO:0009055 electron transfer activity 4/1011 116/18639 0.0344827586206897 0.635731095876394 0.88073650827568 0.942302555456116 GO:0015276 ligand-gated monoatomic ion channel activity 7/1011 186/18639 0.0376344086021505 0.69383555087585 0.883429564081951 0.944267099532793 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/1011 39/18639 0.0256410256410256 0.472723122574755 0.886643797029776 0.946784364657765 GO:0022834 ligand-gated channel activity 7/1011 188/18639 0.0372340425531915 0.686454321611213 0.889745309584191 0.946940703739345 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 2/1011 68/18639 0.0294117647058824 0.542241228835748 0.889966581319407 0.946940703739345 GO:0004532 RNA exonuclease activity 1/1011 40/18639 0.025 0.460905044510386 0.892805255158965 0.946940703739345 GO:0015036 disulfide oxidoreductase activity 1/1011 40/18639 0.025 0.460905044510386 0.892805255158965 0.946940703739345 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/1011 40/18639 0.025 0.460905044510386 0.892805255158965 0.946940703739345 GO:0061791 GTPase motor activity 1/1011 40/18639 0.025 0.460905044510386 0.892805255158965 0.946940703739345 GO:1990606 membrane scission GTPase motor activity 1/1011 40/18639 0.025 0.460905044510386 0.892805255158965 0.946940703739345 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 6/1011 167/18639 0.0359281437125748 0.662378507080794 0.895449361019267 0.947920457102048 GO:0016874 ligase activity 6/1011 167/18639 0.0359281437125748 0.662378507080794 0.895449361019267 0.947920457102048 GO:0016247 channel regulator activity 6/1011 168/18639 0.0357142857142857 0.65843577787198 0.898537332605295 0.948742631325508 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/1011 41/18639 0.024390243902439 0.449663458058913 0.898632121497708 0.948742631325508 GO:0016782 transferase activity, transferring sulphur-containing groups 2/1011 70/18639 0.0285714285714286 0.526748622297584 0.899307204985326 0.948742631325508 GO:0003697 single-stranded DNA binding 4/1011 121/18639 0.0330578512396694 0.609461215881502 0.899669736601775 0.948742631325508 GO:0008307 structural constituent of muscle 1/1011 42/18639 0.0238095238095238 0.438957185247986 0.904142548703096 0.951638098061903 GO:0051879 Hsp90 protein binding 1/1011 42/18639 0.0238095238095238 0.438957185247986 0.904142548703096 0.951638098061903 GO:0008200 ion channel inhibitor activity 1/1011 43/18639 0.0232558139534884 0.428748878614312 0.909353705516624 0.956209717060419 GO:0004521 RNA endonuclease activity 2/1011 73/18639 0.0273972602739726 0.505101418641519 0.911940508923087 0.95710327698404 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/1011 73/18639 0.0273972602739726 0.505101418641519 0.911940508923087 0.95710327698404 GO:0016758 hexosyltransferase activity 7/1011 197/18639 0.0355329949238579 0.655093464278721 0.914709713845258 0.958426487743718 GO:0003678 DNA helicase activity 2/1011 74/18639 0.027027027027027 0.498275723795012 0.915810427943861 0.958426487743718 GO:0003684 damaged DNA binding 2/1011 74/18639 0.027027027027027 0.498275723795012 0.915810427943861 0.958426487743718 GO:0019003 GDP binding 2/1011 75/18639 0.0266666666666667 0.491632047477745 0.919520149858588 0.961395830307556 GO:0051536 iron-sulfur cluster binding 2/1011 76/18639 0.0263157894736842 0.485163204747774 0.923075645686008 0.962659639008749 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1011 46/18639 0.0217391304347826 0.400786995226422 0.92334958115449 0.962659639008749 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/1011 46/18639 0.0217391304347826 0.400786995226422 0.92334958115449 0.962659639008749 GO:0005506 iron ion binding 5/1011 154/18639 0.0324675324675325 0.598577979883618 0.925389168815011 0.963874162603159 GO:0051540 metal cluster binding 2/1011 77/18639 0.025974025974026 0.478862383906894 0.926482710783492 0.964101933223238 GO:0005216 monoatomic ion channel activity 18/1011 448/18639 0.0401785714285714 0.740740250105977 0.92977821670941 0.966566333574387 GO:0008168 methyltransferase activity 7/1011 204/18639 0.0343137254901961 0.632614766975039 0.930605154194578 0.966566333574387 GO:0004497 monooxygenase activity 3/1011 106/18639 0.0283018867924528 0.521779295672135 0.931788610617765 0.96688422683689 GO:0000287 magnesium ion binding 8/1011 230/18639 0.0347826086956522 0.641259192362276 0.935782822801657 0.970115400496168 GO:0099106 ion channel regulator activity 5/1011 160/18639 0.03125 0.576131305637982 0.939069524813795 0.972607722128573 GO:0004518 nuclease activity 7/1011 209/18639 0.0334928229665072 0.617480442406258 0.94031073091249 0.972945613214093 GO:0003743 translation initiation factor activity 1/1011 51/18639 0.0196078431372549 0.361494152557165 0.94204443675085 0.972945613214093 GO:0005272 sodium channel activity 1/1011 51/18639 0.0196078431372549 0.361494152557165 0.94204443675085 0.972945613214093 GO:0008135 translation factor activity, RNA binding 2/1011 83/18639 0.0240963855421687 0.444245826034107 0.944110903046656 0.974166868124921 GO:0008146 sulfotransferase activity 1/1011 53/18639 0.0188679245283019 0.347852863781423 0.948177547179249 0.976534258870591 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/1011 53/18639 0.0188679245283019 0.347852863781423 0.948177547179249 0.976534258870591 GO:0016741 transferase activity, transferring one-carbon groups 7/1011 215/18639 0.0325581395348837 0.600248430060037 0.950357745563632 0.977610177196957 GO:0050661 NADP binding 1/1011 54/18639 0.0185185185185185 0.341411144081767 0.950996470013737 0.977610177196957 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/1011 57/18639 0.0175438596491228 0.323442136498516 0.958566892929574 0.984474106251995 GO:0008408 3'-5' exonuclease activity 1/1011 58/18639 0.0172413793103448 0.317865547938197 0.960821164334601 0.985870505676657 GO:0004540 RNA nuclease activity 3/1011 121/18639 0.0247933884297521 0.457095911911126 0.963090220756264 0.987279463510142 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/1011 60/18639 0.0166666666666667 0.30727002967359 0.964968757875981 0.98736821836521 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1011 60/18639 0.0166666666666667 0.30727002967359 0.964968757875981 0.98736821836521 GO:0016836 hydro-lyase activity 1/1011 61/18639 0.0163934426229508 0.302232816072384 0.966875027631478 0.988401002272624 GO:0022824 transmitter-gated monoatomic ion channel activity 1/1011 63/18639 0.0158730158730159 0.292638123498658 0.970382290797442 0.990149337461834 GO:0022835 transmitter-gated channel activity 1/1011 63/18639 0.0158730158730159 0.292638123498658 0.970382290797442 0.990149337461834 GO:0019783 ubiquitin-like protein peptidase activity 3/1011 127/18639 0.0236220472440945 0.435500829458632 0.971324406111597 0.9901937979047 GO:0008173 RNA methyltransferase activity 1/1011 67/18639 0.0149253731343284 0.275167190752469 0.976322971512403 0.99436960684535 GO:0140223 general transcription initiation factor activity 1/1011 68/18639 0.0147058823529412 0.271120614417874 0.977611872858568 0.994762958347314 GO:0005261 monoatomic cation channel activity 11/1011 341/18639 0.032258064516129 0.594716186465014 0.979871848193706 0.99614278294231 GO:0140299 molecular sensor activity 1/1011 71/18639 0.0140845070422535 0.259664813808668 0.981073017101492 0.996444668060686 GO:0004843 cysteine-type deubiquitinase activity 2/1011 108/18639 0.0185185185185185 0.341411144081767 0.982789896940982 0.997269306104017 GO:0019001 guanyl nucleotide binding 13/1011 400/18639 0.0325 0.599176557863502 0.985467033506962 0.997618766725392 GO:0032561 guanyl ribonucleotide binding 13/1011 400/18639 0.0325 0.599176557863502 0.985467033506962 0.997618766725392 GO:0005525 GTP binding 12/1011 378/18639 0.0317460317460317 0.585276246997315 0.986219909167992 0.997618766725392 GO:0101005 deubiquitinase activity 2/1011 115/18639 0.0173913043478261 0.320629596181138 0.987726856546365 0.997618766725392 GO:0016835 carbon-oxygen lyase activity 1/1011 79/18639 0.0126582278481013 0.233369642790069 0.987907248709691 0.997618766725392 GO:0000049 tRNA binding 1/1011 80/18639 0.0125 0.230452522255193 0.988565964849481 0.997618766725392 GO:0004527 exonuclease activity 1/1011 84/18639 0.0119047619047619 0.219478592623993 0.990861316248228 0.998522155969768 GO:0008528 G protein-coupled peptide receptor activity 2/1011 122/18639 0.0163934426229508 0.302232816072384 0.991273356289406 0.998522155969768 GO:0001653 peptide receptor activity 2/1011 128/18639 0.015625 0.288065652818991 0.993499178963028 0.999850315266902 GO:0140098 catalytic activity, acting on RNA 11/1011 387/18639 0.0284237726098191 0.524026407195271 0.995066338296124 0.999999947182514 GO:0030594 neurotransmitter receptor activity 1/1011 97/18639 0.0103092783505155 0.190063935880571 0.995589803159332 0.999999947182514 GO:0140101 catalytic activity, acting on a tRNA 1/1011 139/18639 0.00719424460431655 0.132634545182845 0.999582556269153 0.999999947182514 GO:0003735 structural constituent of ribosome 1/1011 175/18639 0.00571428571428571 0.105349724459517 0.999944906692532 0.999999947182514 GO:0045182 translation regulator activity 4/1011 356/18639 0.0112359550561798 0.207148334611409 0.999996611958307 0.999999947182514 GO:0030371 translation repressor activity 3/1011 329/18639 0.00911854103343465 0.168111262435399 0.999998141987968 0.999999947182514 GO:1903231 mRNA base-pairing translational repressor activity 1/1011 298/18639 0.00335570469798658 0.0618664489275686 0.999999947182514 0.999999947182514