category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	86/1111	250/9376	2.903099909991	CTSS/LAPTM5/VAMP8/CTSD/ASAH1/HEXB/CLTB/CD68/CTSB/ACP5/PSAP/LGMN/LIPA/TPP1/CTSZ/SLC15A3/SLC11A1/TLR3/RRAGD/IDS/LAMP2/GNS/SLC17A5/PPT1/LAPTM4A/ABCA5/CTBS/SLC11A2/AP1S2/ACP2/ATP6V1G1/ATP6V0B/AP2A2/GNPTG/NAGLU/CTSA/DMXL2/ENTPD4/ATP6V0E1/GGA1/SCARB2/BLOC1S1/CD63/CLCN7/VAMP7/OSTM1/MITF/ATP6V1F/ATP6V1B2/TPCN1/BLOC1S6/ARSA/VPS13C/HEXA/CTSO/ATP6V0D1/ATP6AP1/MCOLN1/HGSNAT/SMPD1/MANBA/GGA2/M6PR/PLA2G15/CLTC/AP2S1/ATP6V1C1/AP2M1/GPR155/GALC/SLC29A3/CTNS/ATP6V0A1/CTSH/TLR7/DTNBP1/ATP6V1E1/TFE3/TLR8/GGA3/AP5B1/FIG4/GUSB/CD164/AP4E1/SUMF1	11.181822643027
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	37/1111	78/9376	4.00323109234	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/FCGR3A/HLA-DMB/NCF2/HLA-DQA2/CYBB/FCGR1A/HLA-DRB5/ITGAM/PTPN6/FCGR2A/NFKBIA/STAT1/IL1B/HLA-DOA/IFNGR1/IL10/NCF4/PTGS2/JAK2/ELK1/TLR4/PRKCB/TLR2/IRAK4/RELA/FOS/TAB2/FCGR3B/NFKB1	9.76478129446519
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	59/1111	181/9376	2.75091376540969	HLA-DRA/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/CTSD/HLA-DQB1/HLA-DQA1/FCER1G/ITGB2/HLA-DMA/FCGR3A/HLA-DMB/LSP1/CD14/HLA-DQA2/PLK3/IL18/LAMP2/ITGAX/FCGR1A/HLA-DRB5/ATP6V0B/SYK/ITGAM/FCGR2A/BID/STAT1/IL1B/HLA-DOA/IFNGR1/ARHGEF12/IL10/TRADD/CORO1A/JAK2/TLR1/TLR4/ATP6V0D1/TLR2/ATP6AP1/IRAK4/EP300/CALM2/MAPK8/CEBPB/ATP6V0A1/RELA/CREBBP/CIITA/FCGR2B/CAMK2D/RAB5A/BCL2/VDR/FCGR3B/NFKB1/CLEC4E	8.72066124199242
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	53/1111	155/9376	2.88567695479225	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/CTSS/HLA-DQB1/HLA-DQA1/MSR1/ITGB2/HLA-DMA/FCGR3A/OLR1/HLA-A/HLA-DMB/CD14/NCF2/CD36/HLA-DQA2/STX7/HLA-F/CYBB/LAMP2/TUBA4A/FCGR1A/HLA-DRB5/MARCO/ATP6V1G1/ATP6V0B/ITGAM/FCGR2A/ATP6V0E1/HLA-DOA/CORO1A/NCF4/ATP6V1F/ATP6V1B2/TLR4/ATP6V0D1/TLR2/ATP6AP1/TUBA1A/STX12/M6PR/ATP6V1C1/ATP6V0A1/ATP6V1E1/SCARB1/FCGR2B/RAB5A/FCGR3B/STX18/DYNC1LI2	8.6789137075576
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	37/1111	95/9376	3.28686342318442	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/CCL5/ACP5/HLA-DMB/CXCL2/TNFSF13B/HLA-DQA2/CXCL3/CD86/IL18/CCL3/HLA-DRB5/ICAM1/ATP6V1G1/CCL20/ATP6V0B/IL1B/ATP6V0E1/HLA-DOA/ITGAL/ATP6V1F/ATP6V1B2/TLR4/ATP6V0D1/TLR2/ATP6AP1/ATP6V1C1/ATP6V0A1/ATP6V1E1/FOS	8.21345502387938
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	40/1111	112/9376	3.01401568728301	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/LY96/HLA-DQA2/ALOX5/HLA-DRB5/NFKBIA/STAT1/BIRC3/HLA-DOA/CD40/IFNGR1/IL10/LAMB2/BIRC7/PIK3R5/JAK2/STAT3/BCL2L1/LAMB3/TLR4/TLR2/IKBKB/IRAK4/SOCS1/PDPK1/HSPA6/MAPK8/HSPA1B/RELA/CIITA/TAB2/BCL2/NFKB1	7.86129015034309
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	45/1111	142/9376	2.67440828589901	TYROBP/SQSTM1/TREM2/FCGR3A/ACP5/SPI1/NCF2/TGFBR1/LILRB4/FCGR1A/LCP2/OSCAR/CSF1R/SYK/SIRPA/JUND/FCGR2A/NFKBIA/JUNB/STAT1/BTK/IL1B/CYLD/IFNGR1/LILRB2/NCF4/MITF/LILRB3/LILRA2/LILRB1/IKBKB/NFKB2/SOCS1/MAP2K7/RELB/MAPK8/PIK3CA/RELA/SIRPB1/FOS/TAB2/FCGR2B/FCGR3B/NFKB1/IFNAR1	7.3710921446139
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	51/1111	173/9376	2.48786959620818	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/CCL5/HLA-DMB/HLA-DQA2/TRIM25/TLR3/IL18/PYCARD/HLA-DRB5/ICAM1/CASP1/IFIH1/BID/NFKBIA/STAT1/IL1B/HLA-DOA/IFNGR1/TRADD/CXCL10/MX2/JAK2/TRAF3/TLR4/PRKCB/IKBKB/HNRNPUL1/DNAJB1/IRAK4/EP300/OAS2/TLR7/PIK3CA/RELA/CREBBP/KPNA6/CIITA/CALCOCO2/TNFSF10/TNFRSF10A/NLRP3/ADAR/NFKB1/TBK1/IFNAR1	7.24176535004748
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	57/1111	205/9376	2.34652148141643	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-A/HLA-DMB/CDKN1A/TAPBP/CD44/HLA-DQA2/TAPBPL/HLA-F/VIM/GADD45B/HLA-DRB5/ICAM1/CD58/RBPJ/SYK/BID/NFKBIA/STAT1/BTK/GADD45G/HLA-DOA/CD40/ITGAL/TRADD/CXCL10/TRAF3/BCL2L11/STAT3/TLR2/IKBKB/NFKB2/TNFAIP3/IRAK4/CIR1/ENTPD1/NFKBIE/HES1/MAP2K7/RELB/MAPK8/OAS2/PIK3CA/RELA/TAB2/DDB2/BCL2/NFKB1/TBK1/IFNAR1	7.14665979536696
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	59/1111	216/9376	2.3051638497183	OLR1/CCL5/CXCL2/CD14/LY96/NCF2/CD36/MMP9/CXCL3/CYBB/IL18/CCL3/PYCARD/ABCA1/DDIT3/ICAM1/CASP1/BID/NFKBIA/POU2F3/IL1B/CD40/ABCG1/SOD2/NCF4/POU2F2/NFE2L2/JAK2/TRAF3/CASP7/STAT3/BCL2L1/TLR4/TLR2/IKBKB/PLCB2/IRAK4/ATF4/VAV1/CALM2/PDPK1/HSPA6/MAP2K7/MAPK8/MAP3K5/HSPA1B/PIK3CA/RELA/FOS/TAB2/TNFSF10/CAMK2D/BCL2/TNFRSF10A/NLRP3/RXRB/NFKB1/TBK1/RAP1A	7.1148445162569
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	37/1111	105/9376	2.97382881145257	CXCL2/BCL2A1/CD14/LY96/TNFSF13B/CXCL3/TRIM25/PLAU/GADD45B/CFLAR/ICAM1/SYK/NFKBIA/BIRC3/BTK/IL1B/GADD45G/CD40/CYLD/TRADD/PTGS2/TRAF3/BCL2L1/TAB3/TLR4/PRKCB/IKBKB/NFKB2/TNFAIP3/IRAK4/RELB/RELA/TAB2/BCL2/NFKB1/LTBR/ATM	7.45696460484209
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	39/1111	119/9376	2.76580263068324	CCL5/CXCL2/MMP9/CXCL3/IRF1/CFLAR/ICAM1/CCL20/BCL3/NFKBIA/JUNB/BIRC3/IL1B/CREB5/CYLD/TRADD/CXCL10/PTGS2/TRAF3/RPS6KA5/CASP7/TAB3/IKBKB/TNFAIP3/ATF4/RHBDF2/MAP2K7/MAPK8/MAP3K5/CEBPB/PIK3CA/RELA/ATF6B/FOS/TAB2/MLKL/NFKB1/CREB3L2/RHBDF1	7.10725253446171
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	57/1111	224/9376	2.14748617718915	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/HLA-A/HLA-DMB/CDKN1A/SPI1/STAT5B/TGFBR1/HLA-DQA2/HLA-F/CD4/STAT5A/HLA-DRB5/ADCY7/ICAM1/ANAPC13/ZFP36/NFKBIA/MMP7/IL2RG/HLA-DOA/CD40/CREB5/ITGAL/ELK1/CDKN2B/BCL2L1/IKBKB/NFKB2/SMAD4/ANAPC16/EP300/CRTC2/ATF4/RELB/MAPK8/KAT5/VAC14/PIK3CA/RELA/CREBBP/ATF6B/FOS/PRKACB/MAP3K3/TBP/NFKB1/LTBR/ATM/CREB3L2	6.37286479667533
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	33/1111	99/9376	2.81308130813081	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/FCGR3A/HLA-DMB/C1QB/C1QA/HLA-DQA2/C5AR1/FPR3/C1QC/C3AR1/FCGR1A/CFB/HLA-DRB5/ICAM1/ITGAM/PTAFR/FCGR2A/HLA-DOA/FPR1/ITGAL/IL10/C2/SELPLG/KRT27/FCGR2B/FCGR3B	6.64893884268431
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	35/1111	109/9376	2.70984896654803	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/EBI3/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/STAT5B/TGFBR1/HLA-DQA2/CD4/STAT5A/HLA-DRB5/AHR/STAT6/NFKBIA/STAT1/IL1B/IL2RG/HLA-DOA/IL6R/IFNGR1/JAK2/STAT3/IKBKB/SMAD4/NFKBIE/MAPK8/RELA/FOS/IL1RAP/RXRB/NFKB1	6.58298183031789
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	48/1111	180/9376	2.25046504650465	HLA-DRA/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/CCL5/HLA-A/HLA-DMB/TAPBP/HLA-DQA2/TAPBPL/HLA-F/TLR3/TNFRSF14/HLA-DRB5/SYK/IFIH1/BID/NFKBIA/POU2F3/SP100/STAT1/PILRA/BIRC3/IL1B/HLA-DOA/IFNGR1/BST2/TRADD/POU2F2/JAK2/TRAF3/BCL2L1/TLR2/IKBKB/IRAK4/OAS2/PIK3CA/RELA/TAB2/BCL2/NFKB1/TBK1/IFNAR1	6.21054290813417
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	49/1111	187/9376	2.21135268607075	MAP1LC3B/CTSB/CCL5/GABARAPL1/CXCL2/GABARAPL2/CXCL3/GPSM3/CYBB/IL18/GABARAP/GBP2/PYCARD/NAMPT/IFI16/CASP1/NFKBIA/RBCK1/STAT1/BIRC3/IL1B/NEK7/GBP3/TXNIP/TRAF3/BCL2L1/TAB3/TLR4/IKBKB/P2RX7/TNFAIP3/GBP4/PLCB2/IRAK4/TRPM7/GBP5/MFN2/MAP1LC3B2/PSTPIP1/MAPK8/OAS2/RELA/TXN/TAB2/BCL2/NLRP3/NFKB1/TBK1/IFNAR1	6.13449084801117
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	25/1111	66/9376	3.19668330469411	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-DQA2/IL18/HLA-DRB5/STAT6/STAT1/IL1B/IL2RG/HLA-DOA/IFNGR1/IL10/STAT3/TLR4/TLR2/STAT4/RELA/TLR5/NFKB1	6.56577226843283
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	38/1111	133/9376	2.41121254982641	CDKN1A/GABARAPL1/TGFBR1/GABARAPL2/IRS2/PLK3/HOMER3/GABARAP/GADD45B/EGFR/FOXO3/BCL6/GADD45G/PRKAG2/IL10/SOD2/CDKN2B/SOS2/BCL2L11/STAT3/SGK3/IKBKB/FBXO32/SMAD4/EP300/IL7R/PDPK1/FBXO25/MAPK8/PIK3CA/ARAF/CREBBP/SIRT1/TNFSF10/S1PR4/FOXO4/SOS1/ATM	6.00942629049572
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	30/1111	93/9376	2.72233674980401	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/STAT5B/HLA-DQA2/CD4/STAT5A/HLA-DRB5/RBPJ/STAT6/NFKBIA/STAT1/IL2RG/HLA-DOA/IFNGR1/NOTCH2/JAK2/IKBKB/NFKBIE/STAT4/MAPK8/RELA/FOS/MAML2/NFKB1	6.11979121809761
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	43/1111	163/9376	2.22630361195629	CDKN1A/STAT5B/TGFBR1/MMP9/TLR3/STAT5A/IFIH1/STAT6/BID/NFKBIA/STAT1/CREB5/JAK2/TRAF3/ELK1/SOS2/STAT3/TLR4/PRKCB/TLR2/IKBKB/ATP6AP1/SMAD4/IRAK4/EP300/ATF4/STAT4/MAP2K7/MAPK8/PIK3CA/RELA/ARAF/CREBBP/ATF6B/FOS/TAB2/DDB2/BCL2/NFKB1/TBK1/SOS1/CREB3L2/IFNAR1	5.79045262527414
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	32/1111	105/9376	2.57196005314817	SQSTM1/MAP1LC3B/GABARAPL1/GABARAPL2/PINK1/AMFR/GABARAP/MRAS/RRAS/OPTN/ULK1/FIS1/FOXO3/NBR1/MITF/BCL2L1/SMURF2/TBC1D15/UBC/ATF4/MFN2/MAP1LC3B2/USP8/MAPK8/ATG9A/RELA/MUL1/BNIP3L/CALCOCO2/TFE3/RAB5A/TBK1	5.93873714302769
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	66/1111	300/9376	1.85663366336634	HSPB1/CD14/TGFBR1/DUSP2/RASA1/DUSP1/MAP3K2/ANGPT2/MRAS/MAPKAPK3/ARRB2/STK3/RRAS/DDIT3/GADD45B/EGFR/CSF1R/JUND/IL1B/GADD45G/RASGRP3/PDGFB/DUSP10/TRADD/RAPGEF2/EREG/ELK1/RPS6KA5/SOS2/PRKCB/IKBKB/NFKB2/DUSP3/IRAK4/PTPRR/RAC2/ATF4/MAP4K3/ARRB1/HSPA6/MAP2K7/RELB/MAPK8/MAP3K5/HSPA1B/RELA/VEGFB/ARAF/MEF2C/PAK2/FOS/TAB2/RPS6KA3/PLA2G4C/CACNA2D4/IL1RAP/PRKACB/PPM1A/MAP3K3/RASA2/MAPK8IP3/MAPKAPK2/NFKB1/IGF2/SOS1/RAP1A	5.52878573537352
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	32/1111	109/9376	2.47757619798677	SPP1/CCL5/CD14/LY96/CD86/TLR3/CCL3/CXCL9/NFKBIA/STAT1/IL1B/CD40/CXCL10/TRAF3/TLR1/TLR4/TLR2/IKBKB/IRF5/IRAK4/MAP2K7/MAPK8/TLR7/PIK3CA/RELA/FOS/TAB2/TLR5/TLR8/NFKB1/TBK1/IFNAR1	5.68872307119289
Human Diseases	Immune disease	hsa05330	Allograft rejection	17/1111	39/9376	3.67864478755568	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-F/CD86/HLA-DRB5/HLA-DOA/CD40/IL10	6.14560989236589
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	24/1111	70/9376	2.89345505979169	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-F/CD86/HLA-DRB5/ICAM1/BID/HLA-DOA/CD40/ITGAL/ABL2/SGCE/RAC2/EIF4G2	5.8296668466681
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	37/1111	137/9376	2.27921186279212	CTSS/CTSD/CTSB/BCL2A1/CTSZ/CSF2RB/TUBA4A/DDIT3/GADD45B/CFLAR/BBC3/BID/NFKBIA/PMAIP1/BIRC3/GADD45G/NOL3/TRADD/BCL2L11/CASP7/BCL2L1/CTSO/IKBKB/TUBA1A/ATF4/PDPK1/MAPK8/MAP3K5/CTSH/PIK3CA/RELA/FOS/TNFSF10/BCL2/TNFRSF10A/NFKB1/ATM	5.52982664691102
Human Diseases	Immune disease	hsa05310	Asthma	15/1111	32/9376	3.95589558955896	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/PRG2/HLA-DQB1/HLA-DQA1/FCER1G/HLA-DMA/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-DOA/CD40/IL10	6.14071444745464
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	56/1111	248/9376	1.90563572486281	CD14/DYNLRB1/LY96/PTPRC/IL18/SNX9/TUBA4A/PFN2/PYCARD/RRAS/NCKAP1L/CYTH3/CASP1/NFKBIA/DYNLT1/DYNLT3/BIRC3/IL1B/TRADD/CASP7/KPNA3/TAB3/STX10/TLR4/CYTH4/TLR2/IKBKB/SKP1/TUBA1A/MYL12B/PIK3C2B/IRAK4/CYTH2/ABI1/M6PR/MAP2K7/MAPK8/PIK3CA/RELA/TXN/S100A10/FOS/TAB2/TLR5/CYTH1/TNFSF10/KIF5B/MLKL/RAB5A/BCL2/ACTR3C/TNFRSF10A/NLRP3/NFKB1/DCTN4/DYNC1LI2	5.2992304873161
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	28/1111	91/9376	2.5966904382746	DAPP1/LILRB4/PIK3AP1/SYK/PTPN6/CD72/NFKBIA/BTK/RASGRP3/LILRB2/SOS2/LILRB3/LILRA2/LILRB1/PRKCB/IKBKB/INPPL1/RAC2/NFKBIE/VAV1/PIK3CA/RELA/FOS/FCGR2B/INPP5D/CD22/NFKB1/SOS1	5.61140617043553
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	26/1111	82/9376	2.67585782968541	HLA-DRA/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/CTSS/HLA-DQB1/HLA-DQA1/HLA-DMA/CTSB/HLA-A/HLA-DMB/TAPBP/LGMN/IFI30/HLA-DQA2/TAPBPL/HLA-F/CD4/HLA-DRB5/HLA-DOA/HSPA6/HSPA1B/CIITA/PSME1	5.58809786814853
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	17/1111	42/9376	3.41588444558742	FTL/SAT1/MAP1LC3B/SLC39A8/CYBB/ACSL3/SLC11A2/PRNP/ACSL1/GPX4/ACSL4/FTH1/MAP1LC3B2/HMOX1/ATG7/LPCAT3/ACSL5	5.75291746364028
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	20/1111	56/9376	3.01401568728301	ITGB2/CXCL2/CD14/CXCL3/IL18/PYCARD/CASP1/ITGAM/NFKBIA/IL1B/CASP7/TLR4/TLR2/NFKB2/CLK1/HSPA6/HSPA1B/RELA/TLR5/NFKB1	5.54204624032572
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	55/1111	250/9376	1.85663366336634	HLA-B/CLTB/HLA-A/CXCR4/TGFBR1/SH3GLB2/HLA-F/SH3KBP1/DAB2/ARRB2/CYTH3/EGFR/ARFGAP3/WWP1/AP2A2/IST1/IL2RG/CHMP3/AGAP3/RAB31/EHD4/SMURF2/ARAP2/CYTH4/RAB11FIP5/ACAP3/CYTH2/GIT2/CLTC/AP2S1/ARRB1/PDCD6IP/ARAP1/AP2M1/HSPA6/USP8/MVB12B/HSPA1B/SNX1/EHD1/STAMBP/RAB11FIP1/RAB35/CYTH1/ZFYVE27/WIPF2/PIP5K1B/KIF5B/GRK4/RAB5A/ACTR3C/SMAP2/VPS37B/CHMP1B/CHMP5	5.03322271391109
Human Diseases	Infectious disease: viral	hsa05162	Measles	35/1111	136/9376	2.17186424524805	STAT5B/STAT5A/BBC3/IFIH1/BID/NFKBIA/STAT1/IL1B/IL2RG/TRADD/MX2/TRAF3/STAT3/BCL2L1/TLR4/TLR2/IKBKB/TNFAIP3/MSN/IRAK4/HSPA6/MAPK8/OAS2/TLR7/HSPA1B/PIK3CA/RELA/FOS/TAB2/FCGR2B/BCL2/ADAR/NFKB1/TBK1/IFNAR1	5.0469849652607
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	27/1111	94/9376	2.4240381484957	S100A7/S100A9/CXCL2/MMP9/CXCL3/CCL20/JUND/NFKBIA/IL1B/TRADD/CXCL10/PTGS2/CCL7/TRAF3/S100A8/TAB3/IKBKB/TNFAIP3/IL17RE/MAPK8/CEBPB/RELA/FOS/TAB2/LCN2/NFKB1/TBK1	5.08728428379904
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	45/1111	196/9376	1.93758151325337	HLA-B/MAP1LC3B/HLA-A/CDKN1A/CXCL2/CXCL3/HLA-F/CD86/TLR3/ANGPT2/GNG11/CLEC2B/GNGT1/ICAM1/HCK/SYK/ZFP36/BID/NFKBIA/STAT1/IFNGR1/PDGFB/TRADD/PTGS2/PIK3R5/JAK2/TRAF3/STAT3/UBC/IKBKB/EP300/CALM2/GNGT2/MAP2K7/MAP1LC3B2/MAPK8/PIK3CA/RELA/CREBBP/FOS/MAPKAPK2/ATG3/NFKB1/TBK1/IFNAR1	4.86336616875439
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	18/1111	50/9376	3.03812781278128	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/CXCR4/TNFSF13B/HLA-DQA2/CD86/HLA-DRB5/HLA-DOA/CD40/IL10/CCL28/LTBR	5.2977315885827
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	28/1111	100/9376	2.36298829882988	HLA-DRA/CD59/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DMB/CD37/CD14/CD44/CD36/HLA-DQA2/CD4/FCGR1A/HLA-DRB5/CSF1R/ITGAM/CSF3R/IL1B/HLA-DOA/IL6R/CD33/ANPEP/IL7R/CD22/CD1D	5.02380757225274
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	45/1111	200/9376	1.8988298829883	IL18/TUBA4A/PYCARD/NCKAP1L/CYTH3/CASP1/PTPN6/FCGR2A/NFKBIA/IL1B/ARHGEF12/TRADD/MYO1F/CLDN9/CASP7/TAB3/TLR4/CYTH4/IKBKB/GNA13/TUBA1A/MYO5B/IRAK4/CYTH2/MYO5A/ABI1/MAPK8/MYO1G/RELA/HCLS1/PAK2/FOS/TAB2/CLDN1/TLR5/CYTH1/WIPF2/TNFSF10/CLDN23/BAIAP2/ACTR3C/SEC24B/TNFRSF10A/NLRP3/NFKB1	4.71071724338328
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	34/1111	138/9376	2.07923401035756	FN1/IL18/CD4/PYCARD/LCP2/SKAP2/WAS/CASP1/FCGR2A/NFKBIA/IL1B/ARHGEF12/IL10/TLR4/GNAQ/IKBKB/IRAK4/GIT2/RAC2/VAV1/MAP2K7/MAPK8/PIK3CA/RELA/FOS/TAB2/RPS6KA3/WIPF2/PIP5K1B/BAIAP2/ACTR3C/NLRP3/NFKB1/TBK1	4.68260393715185
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/1111	78/9376	2.48849500334649	ITGB2/C1QB/CD14/LY96/C1QA/C1QC/IRF1/PYCARD/CASP1/ITGAM/IRF8/IL1B/IL10/C2/CASP7/TLR4/IRAK4/CALM2/MAPK8/RELA/FOS/NLRP3/NFKB1	4.83973018348638
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/1111	44/9376	3.06881597250634	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-F/CD86/HLA-DRB5/IL1B/HLA-DOA	5.04291992825223
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	39/1111	168/9376	1.95911019673396	FTL/SQSTM1/GLUL/STAT5B/CYBB/TLR3/PYCARD/STAT5A/CFLAR/CASP1/STAT6/BID/RBCK1/STAT1/BIRC3/IL1B/CYLD/IFNGR1/TRADD/CHMP3/JAK2/STAT3/TLR4/TNFAIP3/SMPD1/FTH1/TRPM7/STAT4/MAPK8/PLA2G4C/TNFSF10/CAMK2D/MLKL/BCL2/TNFRSF10A/NLRP3/CHMP1B/CHMP5/IFNAR1	4.59898224014388
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	39/1111	168/9376	1.95911019673396	CSH1/CSH2/CSHL1/CDKN1A/STAT5B/CSF2RB/OSMR/GH2/CISH/SOCS2/STAT5A/EGFR/OSM/STAT6/PTPN6/CSF3R/STAT1/IL2RG/IL6R/IFNGR1/PDGFB/IL10/JAK2/SOS2/STAT3/BCL2L1/FHL1/IL22RA2/EP300/IL7R/SOCS1/STAT4/IL13RA1/PIK3CA/CREBBP/PIAS1/BCL2/SOS1/IFNAR1	4.59898224014388
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	28/1111	105/9376	2.25046504650465	FCER1G/LSP1/PLK3/IRF1/MRAS/PYCARD/RRAS/CASP1/SYK/BCL3/NFKBIA/STAT1/IL1B/CYLD/ARHGEF12/IL10/PTGS2/IKBKB/NFKB2/CALM2/RELB/MAPK8/PIK3CA/RELA/MAPKAPK2/NLRP3/NFKB1/CLEC4E	4.72415517357618
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	43/1111	193/9376	1.88024605569365	CCL5/CXCL16/CXCL2/CXCR4/STAT5B/CXCL3/CCL18/CCL3/ARRB2/GNG11/GNGT1/ADCY7/WAS/FGR/CCL20/HCK/CXCL9/DOCK2/NFKBIA/STAT1/FOXO3/CXCL10/PIK3R5/CCL7/JAK2/SOS2/STAT3/PRKCB/GNAQ/IKBKB/PLCB2/RAC2/VAV1/ARRB1/GNGT2/CCL28/PIK3CA/RELA/PRKACB/GRK4/NFKB1/SOS1/RAP1A	4.53014067867051
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/1111	45/9376	3.0006200620062	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-F/CD86/HLA-DRB5/IL1B/HLA-DOA	4.93205624283137
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	37/1111	160/9376	1.95157515751575	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMA/HLA-A/HLA-DMB/PTPRC/HLA-DQA2/ALCAM/HLA-F/CD86/CD4/ESAM/HLA-DRB5/ICAM1/CD58/GLG1/ITGAM/SIGLEC1/HLA-DOA/CD40/ITGAL/SDC2/CLDN9/CADM1/CD99/SPN/SELPLG/CD99L2/CLDN1/CD22/CLDN23	4.45095386258597
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	29/1111	115/9376	2.12815716354244	CDKN1A/NR4A2/MAFB/ARRB2/EGFR/ADCY7/WNK1/JUND/HBEGF/CREB5/AKAP13/PRKCB/GNAQ/GNA13/PLCB2/MEF2D/ATF4/ARRB1/MEF2A/ARAF/MEF2C/ATF6B/FOS/PRKACB/BCL2/VDR/RXRB/CREB3L2/PDE4B	4.46283491584843
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	34/1111	144/9376	1.99259925992599	CXCL2/C1QB/CD14/LY96/C1QA/C5AR1/CXCL3/C1QC/C3AR1/NFKBIA/FOXO3/IL1B/ACADVL/PRKAG2/LPIN2/TRADD/C2/TRAF3/TAB3/TLR4/IKBKB/IRAK4/SREBF1/LPIN1/MAP2K7/MAPK8/MAP3K5/RELA/SIRT1/TAB2/ALDH3A2/NFKB1/TBK1/CPT1A	4.40076860711981
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	17/1111	54/9376	2.65679901323466	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-A/HLA-DMB/HLA-DQA2/HLA-F/CD86/HLA-DRB5/HLA-DOA/CD40/IL10	4.47644648084943
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	29/1111	120/9376	2.03948394839484	NFKBIA/FOXO3/MATK/RPS6KA5/SOS2/IKBKB/SH2B3/KIDINS220/IRAK4/NFKBIE/ATF4/CALM2/PSEN1/GAB1/PDPK1/MAP2K7/MAPK8/MAP3K5/PIK3CA/RELA/RPS6KA3/SH2B1/CAMK2D/MAP3K3/BCL2/MAPKAPK2/NFKB1/SOS1/RAP1A	4.20163165277445
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	37/1111	169/9376	1.84764511954154	VAMP8/CTSD/SQSTM1/MAP1LC3B/CTSB/DAPK1/GABARAPL1/GABARAPL2/IRS2/STX7/RRAGD/LAMP2/GABARAP/MRAS/RRAS/CFLAR/OPTN/ULK1/NBR1/BCL2L1/UBC/WDR45/ATG16L2/PDPK1/MAP1LC3B2/MAPK8/ATG9A/PIK3CA/MTMR3/CALCOCO2/PRKACB/BCL2/MTMR4/ATG7/ATG3/TBK1/TP53INP2	4.07680167998753
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	20/1111	71/9376	2.37725180968801	CCL5/CXCL2/CXCL3/EGFR/ATP6V1G1/ATP6V0B/NFKBIA/HBEGF/ATP6V0E1/ATP6V1F/ATP6V1B2/ATP6V0D1/IKBKB/ATP6AP1/ATP6V1C1/MAPK8/ATP6V0A1/RELA/ATP6V1E1/NFKB1	4.2707640277516
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	29/1111	122/9376	2.0060497853064	CSH1/CSH2/CSHL1/STAT5B/IRS2/GH2/SOCS2/STAT5A/ADCY7/JUNB/STAT1/CREB5/JAK2/SOS2/STAT3/PRKCB/GNAQ/PLCB2/EP300/ATF4/SOCS1/MAPK8/PIK3CA/CREBBP/ATF6B/FOS/PRKACB/SOS1/CREB3L2	4.10067999162352
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	40/1111	201/9376	1.67945152724228	CDKN1A/BCL2A1/CD14/SPI1/MMP9/AFF1/FUT8/CD86/HPGD/PLAU/KLF3/FCGR1A/DDIT3/GADD45B/CSF1R/ITGAM/NR4A3/BIRC3/BCL6/GADD45G/CD40/PBX3/MITF/BCL2L1/JMJD1C/BMI1/LYL1/FLI1/ETV6/CEBPB/RELA/PER2/MEF2C/TFE3/CDK9/NCOR1/DDB2/RXRB/NFKB1/ATM	3.5700533827254
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	24/1111	103/9376	1.96642576879047	CCL5/C1QB/C1QA/TGFBR1/SERPINE1/C1QC/CCL3/CFLAR/NFKBIA/IL1B/GNA15/IFNGR1/IL10/TLR4/GNAQ/TLR2/IKBKB/PLCB2/IRAK4/MAPK8/PIK3CA/RELA/FOS/NFKB1	3.61574856607596
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	11/1111	33/9376	2.81308130813081	VAMP8/VAMP2/SNAP23/STX7/STX11/STX4/STX3/VAMP7/BET1/STX18/STX16	3.82518386154925
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	18/1111	70/9376	2.17009129484377	CD36/IRS2/ACSL3/NFKBIA/ACSL1/PRKAG2/TRADD/ACSL4/JAK2/STAT3/IKBKB/NFKBIE/MAPK8/RELA/RXRB/NFKB1/CPT1A/ACSL5	3.60253727377934
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	47/1111	253/9376	1.5677646816065	CAST/SQSTM1/MAP1LC3B/CCL5/CD14/CD44/IL18/RRAGD/PFN2/PYCARD/CYTH3/EGFR/CASP1/NFKBIA/RBCK1/FOXO3/IL1B/TRADD/TNIP1/RPS6KA5/HK3/BCL2L1/TAB3/TLR4/UBC/CYTH4/IKBKB/SKP1/MYL12B/PLCB2/CYTH2/MAP1LC3B2/MAPK8/PIK3CA/RELA/HCLS1/CALCOCO2/TAB2/TLR5/CYTH1/BCL2/ACTR3C/FOXO4/NLRP3/NFKB1/TBK1/ATM	3.35645659353796
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	43/1111	227/9376	1.59862329845319	HLA-B/CCL5/HLA-A/CDKN1A/TAPBP/CXCR4/TAPBPL/HLA-F/CCL3/GNG11/EGFR/GNGT1/ADCY7/PTGER4/BID/NFKBIA/IL1B/IL6R/CREB5/AKAP13/ARHGEF12/TRADD/PTGS2/ELK1/SOS2/STAT3/PRKCB/GNAQ/IKBKB/GNA13/PLCB2/RAC2/ATF4/CALM2/GNGT2/PIK3CA/RELA/ATF6B/PRKACB/NFKB1/TBK1/SOS1/CREB3L2	3.34734880079204
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	18/1111	71/9376	2.13952662871921	STAT5B/IRF1/CISH/SOCS2/STAT5A/STAT1/FOXO3/JAK2/SOS2/STAT3/SOCS1/MAPK8/PIK3CA/RELA/GALT/FOS/NFKB1/SOS1	3.53359443811622
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/1111	83/9376	2.03355275286565	CCL5/SAMHD1/IL18/PYCARD/IFI16/CASP1/TREX1/NFKBIA/IL1B/CXCL10/CASP7/IKBKB/ZDHHC1/RELA/ZCCHC3/MLKL/NLRP3/ADAR/NFKB1/TBK1	3.46748798093402
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	32/1111	157/9376	1.72010067248763	GULP1/C1QB/C1QA/CD36/DUSP2/LIPA/HAVCR2/C1QC/ALOX5/ABCA1/DNMT3A/CASP1/PTGER4/SIRPA/PTPN6/NR1H3/IL10/PTGS2/JAK2/CASP7/SIGLEC10/PLA2G15/CEBPB/SIRPB1/VPS8/SIRT1/GPR132/CD47/CAMK2D/RAB5A/MAPKAPK2/CPT1A	3.33597182440662
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	39/1111	204/9376	1.61338486789855	FN1/CDKN1A/TIMP3/CD44/MMP9/PLAU/MRAS/ANK3/RRAS/EGFR/PLAUR/GPC3/PTPN6/HBEGF/TWIST1/ARHGEF12/CD63/SDC2/ELK1/SOS2/STAT3/TLR4/PRKCB/TLR2/MSN/VAV1/GAB1/PDPK1/NUDT16L1/PIK3CA/ARAF/HCLS1/PRKACB/CAMK2D/PPP1R12C/FZD1/IGF2/SOS1/PPP1R12B	3.24741174601163
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	28/1111	133/9376	1.77668293145104	TYROBP/HLA-B/FCER1G/ITGB2/FCGR3A/HLA-A/CD48/HCST/LCP2/SH3BP2/ICAM1/SYK/PTPN6/LAT2/BID/IFNGR1/ITGAL/SOS2/PRKCB/RAC2/VAV1/PIK3CA/ARAF/TNFSF10/TNFRSF10A/FCGR3B/SOS1/IFNAR1	3.30738188816085
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	18/1111	73/9376	2.08090946080909	CDKN1A/STAT5B/STAT5A/GADD45B/EGFR/FOXO3/GADD45G/SOS2/STAT3/PRKCB/PDPK1/PIK3CA/ARAF/KIF5B/DDB2/RXRB/SOS1/RASSF5	3.3990728794327
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	19/1111	79/9376	2.02969157675261	CLTB/VAMP2/ATP6V1G1/ATP6V0B/AP2A2/ATP6V0E1/STX3/ATP6V1F/ATP6V1B2/SLC1A3/ATP6V0D1/SYT1/CLTC/AP2S1/ATP6V1C1/AP2M1/ATP6V0A1/ATP6V1E1/SLC6A2	3.36953932252162
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	23/1111	103/9376	1.88449136175754	HSPB1/FN1/ITGB2/CXCL2/CD14/CXCL3/ITGAM/IL1B/GNA15/IL10/LAMB2/LAMB3/TLR4/PRKCB/GNAQ/TLR2/PLCB2/PIK3CA/RELA/PRKACB/RAB5A/CD1D/NFKB1	3.30920229598592
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	17/1111	68/9376	2.10981098109811	BCL2A1/CD14/SPI1/STAT5B/FCGR1A/STAT5A/CSF1R/ITGAM/SOS2/STAT3/IKBKB/PIK3CA/RELA/ARAF/PER2/NFKB1/SOS1	3.36741409519703
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	25/1111	116/9376	1.81880256991216	ITGB2/CXCR4/NCF2/MMP9/CYBB/ESAM/ICAM1/ITGAM/ITGAL/NCF4/CLDN9/PRKCB/CD99/MSN/MYL12B/TXK/RAC2/VAV1/SIPA1/PIK3CA/CD99L2/CLDN1/CLDN23/RASSF5/RAP1A	3.25329868070345
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/1111	98/9376	1.89452414629218	GSN/FCGR3A/MARCKS/PTPRC/FCGR1A/WAS/HCK/SYK/FCGR2A/SCIN/PRKCB/INPPL1/RAC2/VAV1/PIK3CA/FCGR2B/INPP5D/PLA2G4C/PIP5K1B/ACTR3C/LIMK2/FCGR3B	3.26361680431557
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	40/1111	214/9376	1.57742877091447	HLA-B/HLA-A/TAPBP/CXCR4/SAMHD1/TAPBPL/HLA-F/CD4/GNG11/GNGT1/AP1S2/BID/NFKBIA/BST2/TRADD/BCL2L1/TLR4/PRKCB/GNAQ/TLR2/IKBKB/SKP1/IRAK4/RAC2/CALM2/GNGT2/MAP2K7/MAPK8/APOBEC3G/PIK3CA/RELA/PAK2/FOS/TAB2/BCL2/LIMK2/NFKB1/TBK1/CUL5/ATM	3.13279084422997
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	20/1111	87/9376	1.94005607457297	CDKN1A/TGFBR1/GADD45B/EGFR/BBC3/PMAIP1/GADD45G/RALGDS/EREG/SOS2/BCL2L11/SMAD4/RAC2/MAPK8/PIK3CA/ARAF/FOS/DDB2/BCL2/SOS1	3.22961046551066
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	18/1111	76/9376	1.99876829788242	OLR1/LPL/CYP27A1/CD36/SORBS1/ACSL3/GK/FABP3/NR1H3/ACSL1/FABP4/ACSL4/UBC/FABP5/PDPK1/RXRB/CPT1A/ACSL5	3.20517177345419
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1111	32/9376	2.63726372637264	BBC3/BID/PMAIP1/BIRC3/BIRC7/BCL2L11/CASP7/BCL2L1/MAPK8/BCL2	3.4013275212911
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	18/1111	77/9376	1.97281026803979	CDKN1A/TGFBR1/GADD45B/EGFR/STAT1/GADD45G/RALGDS/STAT3/BCL2L1/IKBKB/SMAD4/RAC2/MAPK8/PIK3CA/RELA/ARAF/DDB2/NFKB1	3.14250967461182
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	18/1111	77/9376	1.97281026803979	CDKN1A/STAT5B/TGFBR1/STAT5A/GADD45B/NFKBIA/BCR/GADD45G/SOS2/BCL2L1/IKBKB/SMAD4/PIK3CA/RELA/ARAF/DDB2/NFKB1/SOS1	3.14250967461182
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	18/1111	78/9376	1.94751782870595	MTMR1/IMPA2/INPPL1/ITPKC/PIK3C2B/PLCB2/MINPP1/CDIPT/ITPK1/MTM1/OCRL/PIK3CA/MTMR3/INPP5D/PIP5K1B/PIP4K2A/FIG4/MTMR4	3.08078335813681
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	14/1111	55/9376	2.14817118075444	ASAH1/HEXB/SPTLC3/ACER3/PSAP/SGMS2/SGMS1/ARSA/HEXA/SMPD1/CERS6/UGCG/GALC/B4GALT5	3.13096325883745
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	51/1111	298/9376	1.44430013471146	CSH1/CSH2/CSHL1/EBI3/TNFRSF12A/INHBA/CCL5/CXCL16/CXCL2/CXCR4/TGFBR1/TNFSF13B/CXCL3/CSF2RB/OSMR/GH2/IL1RN/CCL18/IL18/CCL3/IL32/CD4/TNFRSF14/CSF1R/TNFSF12/CCL20/OSM/CXCL9/CSF3R/BMPR2/IL1B/IL2RG/IL6R/CD40/RELL2/IFNGR1/IL10/CXCL10/ACKR3/CCL7/IL7R/IL17RE/IL13RA1/IL16/CCL28/IL1RAP/TNFSF10/GDF15/TNFRSF10A/LTBR/IFNAR1	2.85766112276026
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	28/1111	142/9376	1.66407626678161	SQSTM1/NCF2/DUSP1/MMP9/ICAM1/BMPR2/IL1B/PDGFB/SDC2/NFE2L2/SUMO3/IKBKB/GSTT1/RAC2/CALM2/MAP2K7/MAPK8/MAP3K5/PIK3CA/MEF2A/RELA/TXN/MEF2C/FOS/HMOX1/BCL2/NFKB1/GSTO1	2.92340129627958
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/1111	110/9376	1.76456918419115	CDKN1A/SERPINE1/EPAS1/CYBB/ANGPT2/EGFR/EGLN2/IL6R/IFNGR1/STAT3/HK3/TLR4/PRKCB/EP300/PIK3CA/RELA/CREBBP/HMOX1/CAMK2D/BCL2/NFKB1/LTBR/PFKFB3	2.95725124460952
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	7/1111	19/9376	3.10919513003932	HEXB/IDS/GNS/NAGLU/HEXA/HGSNAT/GUSB	3.37401092398679
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	30/1111	156/9376	1.62293152392162	CDKN1A/TLR3/EGFR/CFLAR/BID/NFKBIA/STAT1/NR1H3/YWHAG/TRADD/CXCL10/MX2/TRAF3/SOS2/CLDN9/STAT3/IKBKB/YWHAH/OAS2/PIK3CA/RELA/ARAF/CLDN1/SCARB1/PIAS1/CLDN23/NFKB1/TBK1/SOS1/IFNAR1	2.87646031451422
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	26/1111	130/9376	1.68784878487849	TGFBR1/MMP9/ARRB2/GNG11/EGFR/GNGT1/ADCY7/NFKBIA/GNA15/CREB5/SOS2/PLCB2/ATF4/ARRB1/GNGT2/MAP2K7/MAPK8/PIK3CA/RELA/VEGFB/ATF6B/FOS/PRKACB/NFKB1/SOS1/CREB3L2	2.89540249786447
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	42/1111	238/9376	1.48927833959867	RPS4Y1/C1QB/C1QA/C5AR1/C1QC/C3AR1/CYBB/TLR3/CFB/EGFR/CASP1/SYK/IFIH1/FCGR2A/NFKBIA/HBEGF/STAT1/IL1B/IL6R/C2/CXCL10/MX2/TRAF3/STAT3/TLR4/PRKCB/TLR2/IKBKB/IRAK4/MAPK8/OAS2/TLR7/PIK3CA/RELA/FOS/TAB2/TLR8/NLRP3/ADAR/NFKB1/TBK1/IFNAR1	2.80310993271904
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	20/1111	93/9376	1.81489116653601	FN1/CDKN1A/GADD45B/NFKBIA/BIRC3/GADD45G/LAMB2/BIRC7/PTGS2/TRAF3/CDKN2B/BCL2L1/LAMB3/IKBKB/PIK3CA/RELA/DDB2/BCL2/RXRB/NFKB1	2.89546385469616
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	37/1111	205/9376	1.523180610744	HLA-B/GSN/HLA-A/CDKN1A/STAT5B/HLA-F/STAT5A/RBPJ/SYK/NFKBIA/SP100/PMAIP1/CREB5/YWHAG/SCIN/TRADD/TRAF3/CDKN2B/STAT3/ATP6V0D1/UBR4/NFKB2/EP300/ATF4/YWHAH/VAC14/PIK3CA/RELA/CREBBP/ATF6B/PRKACB/RASA2/MAPKAPK2/TBP/NFKB1/LTBR/CREB3L2	2.77677993862122
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	25/1111	125/9376	1.68784878487849	CTSD/ASAH1/FCER1G/SPTLC3/BID/SGMS2/TRADD/SGMS1/PRKCB/GNAQ/GNA13/SMPD1/CERS6/PLCB2/RAC2/PDPK1/MAPK8/MAP3K5/PIK3CA/RELA/ORMDL1/ORMDL3/S1PR4/BCL2/NFKB1	2.83840837220551
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	17/1111	75/9376	1.91289528952895	CDKN1A/SERPINE1/GADD45B/BBC3/BID/PMAIP1/GADD45G/CD82/ZNF385A/BCL2L1/PPM1D/SESN3/RRM2B/DDB2/BCL2/TNFRSF10A/ATM	2.91010067974635
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	16/1111	69/9376	1.95692612739535	FCER1G/ALOX5AP/ALOX5/LCP2/SYK/BTK/SOS2/RAC2/VAV1/PDPK1/MAP2K7/MAPK8/PIK3CA/INPP5D/PLA2G4C/SOS1	2.92495601497192
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	21/1111	100/9376	1.77224122412241	CCL5/CXCL2/CXCR4/CXCL3/CCL18/IL18/CCL3/TNFRSF14/CSF1R/CCL20/CXCL9/IL2RG/IL6R/IL10/CXCL10/ACKR3/CCL7/CCL28/TNFSF10/TNFRSF10A/LTBR	2.84638636493248
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	19/1111	88/9376	1.82210948367564	CD59/ITGB2/C1QB/SERPINA1/C1QA/C5AR1/SERPINE1/C1QC/C3AR1/PLAU/ITGAX/A2M/CFB/PLAUR/ITGAM/VSIG4/C2/CLU/SERPINE2	2.84073766512135
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	41/1111	238/9376	1.45381933151298	RASA1/ANGPT2/MRAS/GNG11/RRAS/EGFR/GNGT1/CSF1R/RASGRP3/PDGFB/RALGDS/RASAL2/ABL2/ELK1/SOS2/BCL2L1/RALGAPA2/PRKCB/IKBKB/RAC2/CALM2/GAB1/RALGAPB/GNGT2/MAPK8/PLA2G2F/PIK3CA/RELA/VEGFB/PAK2/PLA2G4C/PRKACB/RAB5A/RASA2/FOXO4/NFKB1/TBK1/IGF2/SOS1/RASSF5/RAP1A	2.59996278778131
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	54/1111	333/9376	1.36852604179337	SPP1/HLA-B/FN1/HLA-A/CDKN1A/HES2/HLA-F/IRF1/TLR3/EGFR/RBPJ/ATP6V1G1/ATP6V0B/PTGER4/STAT1/ATP6V0E1/CREB5/TRADD/LAMB2/NOTCH2/MX2/PTGS2/ATP6V1F/TRAF3/ATP6V1B2/SOS2/LAMB3/ATP6V0D1/UBR4/IKBKB/ATP6AP1/EP300/DVL3/HES1/ATP6V1C1/PSEN1/OASL/MFNG/LFNG/ATP6V0A1/PIK3CA/RELA/CREBBP/ATP6V1E1/MAML2/PRKACB/FZD1/TBP/NFKB1/TBK1/SOS1/ATM/CREB3L2/IFNAR1	2.51047136819543
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	16/1111	73/9376	1.84969729849697	CXCR4/SAMHD1/ELL2/CD4/SERINC3/MDFIC/FURIN/BST2/MX2/EP300/PDCD6IP/APOBEC3G/AFF4/CREBBP/ELL/CDK9	2.67199349045053
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	18/1111	86/9376	1.766353379524	CDKN1A/STAT5B/STAT5A/EGFR/HBEGF/ABL2/EREG/ELK1/SOS2/PRKCB/GAB1/MAP2K7/MAPK8/PIK3CA/ARAF/PAK2/CAMK2D/SOS1	2.61753009859911
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/1111	50/9376	2.02541854185419	ITGB2/CD36/IL18/ICAM1/HBB/IL1B/CD40/ITGAL/IL10/SDC2/TLR4/TLR2	2.66538347920691
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	8/1111	28/9376	2.41121254982641	ATP6V1G1/ATP6V0E1/ATP6V1F/ATP6V1B2/ATP6V0D1/ATP6V1C1/ATP6V0A1/ATP6V1E1	2.74178459825197
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/1111	101/9376	1.67113741077078	FN1/STAT5B/TGFBR1/SERPINE1/CYBB/STAT5A/ICAM1/STAT1/IL1B/JAK2/STAT3/PRKCB/SMAD4/PLCB2/MAPK8/PIK3CA/RELA/VEGFB/BCL2/NFKB1	2.48620201754258
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1111	51/9376	1.98570445279822	ATP6V1G1/ATP6V0B/ATP6V0E1/TJP2/ATP6V1F/ATP6V1B2/ATP6V0D1/ATP6AP1/ATP6V1C1/ATP6V0A1/ATP6V1E1/PRKACB	2.5877875847851
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1111	18/9376	2.81308130813081	OLAH/ACSL3/ACSL1/ACSL4/MECR/ACSL5	2.82282042657689
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	17/1111	83/9376	1.7285198399358	LCOR/FBRS/SCML1/MBD6/PHF1/BMI1/RYBP/SKP1/EP300/BCORL1/KDM2A/CREBBP/PHC2/EZH1/PCGF1/CBX7/PHC3	2.444126612643
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1111	52/9376	1.94751782870595	APOE/APOC1/LPL/CYP27A1/CD36/LIPA/ABCA1/MYLIP/NCEH1/APOC2/LRPAP1/SCARB1	2.51193946176086
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	18/1111	90/9376	1.68784878487849	CD4/EGFR/PTPN6/NFKBIA/STAT1/IFNGR1/JAK2/BATF/STAT3/TLR4/TLR2/IKBKB/NFKBIE/PIK3CA/RELA/FOS/MAP3K3/NFKB1	2.40392618556072
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1111	53/9376	1.9107722092964	CLTB/AP2A2/SLC8A1/PRKCB/GNAQ/PLCB2/ATP1B1/CLTC/AP2S1/AP2M1/PRKACB/VDR	2.4377608707742
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/1111	72/9376	1.75817581758176	TRIM25/IFIH1/NFKBIA/CYLD/TRADD/CXCL10/TRAF3/ZNFX1/IKBKB/MAPK8/RELA/OTUD5/ADAR/NFKB1/TBK1	2.36767759407311
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	19/1111	98/9376	1.63617994452506	CDS1/MTMR1/IMPA2/PRKCB/INPPL1/ITPKC/PIK3C2B/PLCB2/CALM2/CDIPT/ITPK1/MTM1/OCRL/PIK3CA/MTMR3/INPP5D/PIP5K1B/PIP4K2A/MTMR4	2.32106373665444
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	19/1111	98/9376	1.63617994452506	HSD3B1/NR4A2/ADCY7/DAGLB/CREB5/CAMK1/PRKCB/GNAQ/ORAI1/PLCB2/ATP1B1/ATF4/CALM2/CAMK1D/ATF6B/SCARB1/PRKACB/CAMK2D/CREB3L2	2.32106373665444
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/1111	174/9376	1.45504205592973	MAN1C1/CRYAB/AMFR/DERL3/DDIT3/DNAJB2/BCAP29/NFE2L2/DNAJB1/SKP1/MAN1A1/ATF4/SYVN1/DNAJC1/HSPA6/MAP2K7/MAPK8/MAP3K5/MBTPS1/UBQLN4/HSPA1B/ATF6B/STUB1/SEL1L/DNAJC5B/UBQLN2/FBXO6/BCL2/SEC24B/EDEM3	2.22129523663125
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	19/1111	99/9376	1.61965287437835	EGFR/WAS/PDGFB/RALGDS/SOS2/GPCPD1/PRKCB/SLC22A5/RAC2/PDPK1/MAPK8/PIK3CA/FOS/PLA2G4C/CHKB/PIP5K1B/SLC44A1/SLC44A2/SOS1	2.27239343705038
NA	NA	hsa03272	Virion - Hepatitis viruses	11/1111	48/9376	1.93399339933993	LAMP2/EGFR/IST1/CD63/TGOLN2/CLDN9/PDCD6IP/CLDN1/SCARB1/CLDN23/CHMP1B	2.37843559469314
Organismal Systems	Immune system	hsa04611	Platelet activation	23/1111	126/9376	1.54049690683354	VAMP8/FCER1G/SNAP23/FERMT3/LCP2/ADCY7/TBXAS1/SYK/FCGR2A/BTK/ARHGEF12/PIK3R5/PTGS1/GNAQ/GNA13/MYL12B/ORAI1/PLCB2/APBB1IP/PIK3CA/PLA2G4C/PRKACB/RAP1A	2.23938547929308
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/1111	106/9376	1.59231017441367	CDKN1A/MMP9/PLAU/EGFR/NFKBIA/CREB5/PDGFB/SOS2/IKBKB/EP300/ATF4/PDPK1/PIK3CA/RELA/ARAF/CREBBP/BCL2/NFKB1/SOS1/CREB3L2	2.24845136011263
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/1111	93/9376	1.63340204988241	MAP3K2/EGFR/ADCY7/HBEGF/ELK1/SOS2/PRKCB/GNAQ/PLCB2/ATF4/CALM2/MAP2K7/MAPK8/PLA2G4C/PRKACB/CAMK2D/MAP3K3/SOS1	2.25059838201587
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1111	61/9376	1.79852739372298	FTL/TRPV6/MT2A/SLC11A2/MT1E/SLC8A1/ATOX1/SLC30A1/ATP1B1/FTH1/TRPM7/HMOX1/VDR	2.29395316052187
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/1111	37/9376	2.05278906269005	APOL1/IL18/ICAM1/HBB/IL1B/IL10/PRKCB/GNAQ/PLCB2	2.35241141158561
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	13/1111	62/9376	1.76951888737261	RBPJ/NOTCH2/TLE2/ATXN1/CIR1/EP300/DVL3/HES1/PSEN1/MFNG/LFNG/CREBBP/MAML2	2.2287853809225
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	27/1111	157/9376	1.45133494241144	HLA-B/SQSTM1/HLA-A/CDKN1A/TGFBR1/SERPINE1/HLA-F/MRAS/RRAS/GADD45B/ZFP36L2/FOXO3/GADD45G/HIPK3/CDKN2B/RAD50/TRPM7/HIPK2/CALM2/HIPK1/PIK3CA/RELA/SIRT1/MAPKAPK2/NFKB1/ATM/RASSF5	2.09087521895156
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1111	109/9376	1.54848512374173	CD36/IRS2/NFKBIA/NR1H3/CREB5/PRKAG2/STAT3/PRKCB/IKBKB/SREBF1/CRTC2/PDPK1/MAPK8/PIK3CA/RELA/MLXIP/RPS6KA3/NFKB1/CPT1A/CREB3L2	2.11168803469289
Human Diseases	Cancer: specific types	hsa05214	Glioma	15/1111	76/9376	1.66564024823535	CDKN1A/GADD45B/EGFR/GADD45G/PDGFB/SOS2/CAMK1/PRKCB/CALM2/PIK3CA/CAMK1D/ARAF/CAMK2D/DDB2/SOS1	2.1361224014042
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	14/1111	70/9376	1.68784878487849	CDKN1A/EPAS1/EGLN2/PDGFB/SOS2/EP300/GAB1/PIK3CA/ARAF/CREBBP/PAK2/TFE3/SOS1/RAP1A	2.11778422518684
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	19/1111	104/9376	1.54178494772554	GDPD5/PLD3/SGMS2/CDS1/PISD/LPIN2/SGMS1/GPCPD1/LPIN1/PLA2G15/CEPT1/CDIPT/PLA2G2F/AGPAT3/PLA2G4C/CHKB/PLD4/LPCAT3/GPD2	2.03693950858784
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	36/1111	227/9376	1.33838229637942	MT-ND2/MT-ND4L/NCF2/MT-ATP6/MT-ND5/SOD1/MT-ND3/MT-ND1/MT-ND4/EGFR/COX4I1/AHR/NFKBIA/FOXO3/PTPRJ/SOD2/ABL2/NFE2L2/SOS2/MT-ATP8/IKBKB/GSTT1/PDPK1/MAP2K7/MAPK8/MAP3K5/PIK3CA/RELA/ARAF/FOS/CBR1/HMOX1/NDUFA13/NFKB1/GSTO1/SOS1	1.89214749396104
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	12/1111	59/9376	1.71645639140185	CDKN1A/GADD45B/EGFR/FOXO3/GADD45G/ELK1/SOS2/PDPK1/PIK3CA/ARAF/DDB2/SOS1	2.02394617240914
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1111	80/9376	1.58235823582358	EGFR/FOXO3/IL6R/PDGFB/JAK2/SOS2/BCL2L11/STAT3/BCL2L1/PRKCB/GAB1/PIK3CA/ARAF/BCL2/SOS1	1.91782244227769
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	34/1111	217/9376	1.32227784990481	STAT5B/KLF4/ARRB2/STAT5A/EGFR/ADCY7/PAQR7/AHR/BCL6/CREB5/NOTCH2/JAK2/SOS2/STAT3/KPNA3/PRKCB/GSTT1/ATF4/ARRB1/PIK3CA/RELA/KPNA6/MIR29A/ATF6B/FOS/RPS6KA3/PRKACB/BCL2/VDR/RXRB/NFKB1/GSTO1/SOS1/CREB3L2	1.76099261096142
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	36/1111	232/9376	1.30953785033676	FN1/GSN/RGCC/ITGB2/IQGAP2/CXCR4/TMSB4X/MRAS/ITGAX/PFN2/RRAS/NCKAP1L/EGFR/DIAPH2/ITGAM/ITGAL/PDGFB/ARHGEF12/SCIN/SOS2/GNA13/MSN/MYL12B/RAC2/VAV1/PIK3CA/ARAF/PAK2/PIP5K1B/PPP1R12C/PIP4K2A/BAIAP2/ACTR3C/LIMK2/SOS1/PPP1R12B	1.75029351894603
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	14/1111	75/9376	1.57532553255326	CDKN1A/BBC3/BID/PMAIP1/BIRC3/BCL2L1/GSTT1/PDPK1/MAP3K5/PIK3CA/BCL2/ERCC1/GSTO1/ATM	1.83400576447553
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	12/1111	62/9376	1.63340204988241	CRYAB/IRS2/SOD1/ADCY7/FOXO3/PRKAG2/SOD2/HSPA6/HSPA1B/PIK3CA/SIRT1/PRKACB	1.83454526222783
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1111	43/9376	1.766353379524	ACAA2/ACSL3/ACSL1/ACADVL/ACSL4/ALDH3A2/HADHA/CPT1A/ACSL5	1.84660458911765
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	16/1111	90/9376	1.5003100310031	IRS2/ADCY7/ULK1/FOXO3/CREB5/PRKAG2/SOD2/SESN3/ATF4/PIK3CA/RELA/ATF6B/SIRT1/PRKACB/NFKB1/CREB3L2	1.74850695511443
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	23/1111	140/9376	1.38644721615019	SPP1/MAP1LC3B/TGFBR1/SERPINE1/MRAS/GNG11/RRAS/GNGT1/ADCY7/PRKAG2/SLC8A1/PIK3R5/GNAQ/GNA13/SMAD4/PLCB2/MEF2D/CALM2/GNGT2/MAP1LC3B2/MEF2A/MEF2C/PRKACB	1.68901488733392
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	27/1111	170/9376	1.3403505056388	CDKN1A/TGFBR1/GADD45B/EGFR/GADD45G/NFE2L2/ELK1/SOS2/BCL2L1/PRKCB/FRAT1/GSTT1/SMAD4/DVL3/GAB1/TXNRD1/BRD7/PIK3CA/ARAF/HMOX1/FZD1/DDB2/SMARCC2/ARID1B/GSTO1/IGF2/SOS1	1.64186185937949
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1111	44/9376	1.72620898453482	VAMP2/AQP3/STX4/CREB5/PRKACB/RAB5A/DCTN4/CREB3L2/DYNC1LI2	1.7701979339176
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	23/1111	142/9376	1.36691979057061	WWP1/UBE2B/ANAPC13/HERC1/BIRC3/BIRC7/SMURF2/UBC/UBE2Q1/SKP1/ANAPC16/SOCS1/SYVN1/UBE2L6/STUB1/UBE2W/UBE2E2/PIAS1/UBE2R2/DDB2/UBA7/CUL5/WWP2	1.61525692912242
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1111	38/9376	1.77668293145104	HEXB/HK3/RENBP/HEXA/GNPDA1/GALT/CHIT1/AMDHD2	1.75885429386392
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/1111	38/9376	1.77668293145104	PTPRC/CD4/BTK/IL2RG/CD40/ORAI1/IL7R/CIITA	1.75885429386392
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/1111	65/9376	1.55801426296476	HSD3B1/ADCY7/NCEH1/CREB5/GNAQ/ORAI1/PLCB2/ATF4/ATF6B/SCARB1/PRKACB/CREB3L2	1.65510310512278
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	52/1111	362/9376	1.2122670830619	SPP1/CSH1/CSH2/CSHL1/FN1/CDKN1A/OSMR/GH2/ANGPT2/PIK3AP1/GNG11/EGFR/GNGT1/CSF1R/OSM/SYK/CSF3R/FOXO3/IL2RG/IL6R/CREB5/PDGFB/YWHAG/LAMB2/PIK3R5/JAK2/EREG/SOS2/BCL2L11/BCL2L1/LAMB3/TLR4/SGK3/TLR2/IKBKB/IL7R/CRTC2/ATF4/YWHAH/PDPK1/GNGT2/TCL1B/PIK3CA/RELA/VEGFB/ATF6B/BCL2/NFKB1/IGF2/SOS1/CREB3L2/IFNAR1	1.51007806465585
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/1111	86/9376	1.47196114960333	CCK/VAMP2/ADCY7/CREB5/PRKCB/GNAQ/PLCB2/ATP1B1/ATF4/KCNN4/ATF6B/KCNMA1/PRKACB/CAMK2D/CREB3L2	1.61201417970321
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1111	52/9376	1.62293152392162	HSD17B1/HSD3B1/CYP19A1/ALOX5/ADCY7/PTGS2/ACOT2/SCARB1/PLA2G4C/PRKACB	1.65143729174004
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1111	59/9376	1.57341835878503	UCK2/NT5E/UPP1/CDA/NME3/DPYD/ENTPD4/ENTPD1/TK2/RRM2B/NT5C2	1.61987234168052
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	22/1111	138/9376	1.3453867125843	FBP1/IRS2/SORBS1/SOCS2/TRIP10/RHOQ/PRKAG2/ELK1/SOS2/HK3/IKBKB/INPPL1/SREBF1/CALM2/SOCS1/PDPK1/MAPK8/PIK3CA/ARAF/PRKACB/FLOT1/SOS1	1.49857136141527
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1111	15/9376	2.25046504650465	HEXB/B3GALT4/HEXA/ST3GAL5	1.77695856996525
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/1111	67/9376	1.51150637451805	PRKCB/GNAQ/PLCB2/EP300/ATF4/CALM2/ARAF/CREBBP/RPS6KA3/PRKACB/CAMK2D/RAP1A	1.54048748799732
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	22/1111	139/9376	1.33570767148657	CTSD/MMP9/EGFR/ADCY7/HBEGF/CREB5/SOS2/GNAQ/PLCB2/ATF4/CALM2/EBAG9/HSPA6/HSPA1B/PIK3CA/ATF6B/FOS/KRT27/PRKACB/BCL2/SOS1/CREB3L2	1.4619227777445
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1111	54/9376	1.56282294896156	SDS/IL4I1/SDSL/DNMT3A/AMD1/CDO1/BCAT2/APIP/BCAT1/LACC1	1.5206713603127
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/1111	170/9376	1.29070789431884	SYNPO/TUBA4A/WAS/AMOTL2/AMOTL1/TJP2/PRKAG2/RAPGEF2/SYMPK/CLDN9/TUBA1A/MSN/MYL12B/AMOT/MAP2K7/MAPK8/MAP3K5/HCLS1/YBX3/CLDN1/PRKACB/CLDN23/ACTR3C/CD1D/ARHGAP17/RAP1A	1.40238429499845
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	29/1111	195/9376	1.25506704516606	ITGB2/FCGR3A/NCF2/C5AR1/FPR3/CYBB/FCGR1A/AQP9/CASP1/SYK/ITGAM/FCGR2A/FPR1/ITGAL/NCF4/TLR4/PRKCB/TLR2/PLCB2/RAC2/SIGLEC9/SELPLG/TLR7/PIK3CA/RELA/TLR8/ATG7/FCGR3B/NFKB1	1.31961700023578
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	22/1111	143/9376	1.2983452191373	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMA/FCGR3A/HLA-DMB/C1QB/C1QA/HLA-DQA2/C1QC/CD86/FCGR1A/HLA-DRB5/FCGR2A/HLA-DOA/CD40/IL10/C2/FCGR3B	1.31806528715158
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1111	63/9376	1.47351878044947	ALOX5/HPGD/TBXAS1/LTA4H/GPX4/PTGS2/PTGS1/LTC4S/PLA2G2F/CBR1/PLA2G4C	1.3825597854724
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1111	29/9376	1.74605046711568	RASSF4/STK3/SAV1/RASSF2/LATS1/LATS2	1.47520482083737
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1111	85/9376	1.38999311695875	UCK2/NT5E/UPP1/CDA/NME3/ENTPD4/GDA/ENTPD1/AK3/TK2/AMPD3/RRM2B/LACC1/NT5C2	1.32420862942843
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	19/1111	122/9376	1.31430848002833	PTPRC/CD4/LCP2/PTPN6/NFKBIA/IL10/SOS2/IKBKB/NFKBIE/VAV1/PDPK1/MAP2K7/MAPK8/PIK3CA/RELA/PAK2/FOS/NFKB1/SOS1	1.28112794622508
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1111	57/9376	1.48056910954253	ACAA2/PPT1/ACSL3/ACSL1/ACADVL/ACSL4/HADHA/CPT1A/MECR/ACSL5	1.33422742118846
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	18/1111	115/9376	1.32092513599186	GNG11/GNGT1/ADCY7/KCNJ2/CREB5/PIK3R5/JAK2/PRKCB/GNAQ/PLCB2/ATF4/GNGT2/PIK3CA/FOS/PRKACB/CAMK2D/BCL2/CREB3L2	1.26953579568703
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1111	93/9376	1.36116837490201	TGFBR1/SORBS1/EGFR/WAS/PTPN6/PTPRJ/SMURF2/LMO7/MYL12B/SMAD4/EP300/RAC2/CREBBP/BAIAP2/RAP1A	1.28330017299544
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	21/1111	138/9376	1.2842327711032	MT-ND2/MT-ND4L/MT-ATP6/MT-ND5/MT-ND3/MT-ND1/MT-ND4/COX4I1/ATP6V1G1/ATP6V0B/ATP6V0E1/ATP6V1F/ATP6V1B2/COX17/MT-ATP8/ATP6V0D1/ATP6AP1/ATP6V1C1/ATP6V0A1/ATP6V1E1/NDUFA13	1.23323531343722
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1111	30/9376	1.68784878487849	ABCC3/IL1B/IKBKB/MTHFR/RELA/NFKB1	1.38344517220775
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	23/1111	154/9376	1.26040656013653	CDKN1A/RGS2/EGFR/ADCY7/KCNJ2/PRKAG2/PTGS2/PIK3R5/ELK1/CAMK1/PRKCB/GNAQ/PLCB2/CALM2/CAMK1D/MEF2C/FOS/PLA2G4C/CACNA2D4/PRKACB/CAMK2D/PPP1R12C/PPP1R12B	1.19459573790242
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/1111	51/9376	1.48927833959867	PLA2G7/PLD3/CEPT1/PAFAH2/PLA2G2F/TMEM86A/PLA2G4C/PLD4/PAFAH1B2	1.28451120325504
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	17/1111	110/9376	1.3042467883152	INHBA/HAMP/TGFBR1/SMAD7/FBN1/EMP3/BMPR2/SKIL/CDKN2B/SMURF2/SKP1/SMAD4/NOG/EP300/CREBBP/NCOR1/SMAD6	1.17678584491397
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/1111	149/9376	1.24606286131969	FCER1G/MRAS/RRAS/CYTH3/EGFR/ADCY7/SYK/PDGFB/RALGDS/PIK3R5/SOS2/CYTH4/GNA13/PLCB2/CYTH2/GAB1/PIK3CA/AGPAT3/PLA2G4C/CYTH1/PIP5K1B/SOS1	1.1100184118311
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1111	32/9376	1.58235823582358	GABARAPL1/GABARAPL2/GABARAP/ATG9A/ATG7/ATG3	1.20981798036028
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/1111	158/9376	1.22849753329763	RRAGD/ATP6V1G1/ULK1/LPIN2/CAB39/ATP6V1F/ATP6V1B2/SOS2/FNIP2/PRKCB/IKBKB/DVL3/LPIN1/ATP6V1C1/PDPK1/CLIP1/PIK3CA/MAPKAP1/ATP6V1E1/RPS6KA3/FNIP1/FZD1/SOS1	1.06197170685174
NA	NA	hsa04517	IgSF CAM signaling	41/1111	299/9376	1.15722073879629	ITGB2/CD84/CD48/RASA1/GLDN/SORBS1/CD86/ITGAX/TUBA4A/ANK3/LCP2/ESAM/ICAM1/MBP/ITGAM/PTPN6/DOK2/SLAMF7/TJP2/ITGAL/CABLES1/RAPGEF2/CADM1/LMO7/PRKCB/TUBA1A/MSN/MYL12B/VAV1/PDPK1/MAPK8/PIK3CA/DOK1/CRTAM/PAK2/PPFIA1/INPP5D/IL1RAP/BAIAP2/ACTR3C/RAP1A	1.012967467798
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	37/1111	268/9376	1.16511949702433	MT-ND2/MT-ND4L/PINK1/DUSP1/SLC39A8/MT-ATP6/MT-ND5/SOD1/MT-ND3/TUBA4A/MT-ND1/DDIT3/MT-ND4/SLC11A2/COX4I1/SLC39A13/NFE2L2/BCL2L1/MT-ATP8/UBC/TUBA1A/SLC39A9/ATF4/CALM2/MFN2/MAPK8/MAP3K5/UBE2L6/PSMD9/TXN/LRRK2/PRKACB/CAMK2D/KIF5B/SLC39A1/NDUFA13/UBA7	1.00548473534787
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/1111	99/9376	1.27867332187764	CDKN1A/MMP9/EGFR/ADCY7/HBEGF/NOTCH2/SOS2/MAPK8/PIK3CA/ARAF/FOS/PRKACB/NCOR1/BCL2/SOS1	1.02195189258354
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/1111	107/9376	1.26194301673158	FBP1/CREB5/PRKAG2/GNAQ/PLCB2/EP300/CRTC2/ATF4/SIK1/CALM2/CREBBP/SIRT1/PRKACB/CAMK2D/CPT1A/CREB3L2	0.999087467748542
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1111	41/9376	1.44084652367676	DAPK1/CDKN1A/MMP9/EGFR/HBEGF/RPS6KA5/ARAF	1.03715442934969
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1111	93/9376	1.27042381657521	LYZ/TRPV6/VAMP2/ADCY7/SLC4A2/PRKCB/GNAQ/PLCB2/ATP1B1/CST3/KCNN4/CALM2/KCNMA1/PRKACB	0.96086743665529
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	22/1111	155/9376	1.19782816991377	HSD3B1/CRH/CDKN1A/EGFR/ADCY7/AHR/NCEH1/CREB5/CDKN2B/GNAQ/ORAI1/PLCB2/DVL3/ATF4/USP8/ATF6B/SCARB1/PRKACB/CAMK2D/FZD1/CREB3L2/RAP1A	0.910513124340945
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	29/1111	212/9376	1.15442487644991	ITGB2/ANGPT2/MRAS/PFN2/RRAS/LCP2/EGFR/ADCY7/CSF1R/ITGAM/DOCK4/FPR1/RASGRP3/ITGAL/PDGFB/RALGDS/RAPGEF2/PRKCB/GNAQ/PLCB2/RAC2/APBB1IP/VAV1/CALM2/SIPA1/PIK3CA/VEGFB/RASSF5/RAP1A	0.833803841100716
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1111	28/9376	1.50700784364151	ACAA2/PPT1/ACOT2/HADHA/MECR	0.985043888009796
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1111	21/9376	1.60747503321761	DPYD/BCAT2/BCAT1/ALDH3A2	1.02173300737698
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1111	89/9376	1.23269855075395	GLUL/GABARAPL1/GABARAPL2/GABARAP/SLC38A1/GNG11/GNGT1/ADCY7/SLC38A2/PRKCB/GNGT2/PRKACB/GABRE	0.808671612150425
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1111	59/9376	1.28734229355139	IRS2/ADCY7/PNPLA2/MGLL/FABP4/PTGS2/PTGS1/PIK3CA/PRKACB	0.811724680223284
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/1111	122/9376	1.17596021897272	FBP1/CD36/IRS2/TBC1D1/ULK1/FOXO3/CREB5/PRKAG2/CAB39/SREBF1/CRTC2/PDPK1/PIK3CA/SIRT1/CPT1A/CREB3L2/PFKFB3	0.717217537145398
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/1111	99/9376	1.19342843375247	ADCY7/PTGER4/IL1B/PRKCB/GNAQ/PLCB2/CALM2/MAPK8/PIK3CA/HRH1/PLA2G4C/IL1RAP/PRKACB/CAMK2D	0.709341506466829
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1111	23/9376	1.46769459554651	LNPEP/CTSA/ATP6AP2/ANPEP	0.823326399401665
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	27/1111	203/9376	1.12246101457436	SPP1/FN1/PARVG/EGFR/BIRC3/PDGFB/LAMB2/ELK1/SOS2/LAMB3/PRKCB/PARVB/MYL12B/RAC2/VAV1/EMP2/PDPK1/MAPK8/PIK3CA/VEGFB/PAK2/PIP5K1B/PPP1R12C/BCL2/SOS1/RAP1A/PPP1R12B	0.646712736484559
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1111	38/9376	1.33251219858828	NT5E/NAMPT/SIRT2/SIRT1/NADK/NT5C2	0.752997760819206
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1111	38/9376	1.33251219858828	SCNN1B/PRKCB/ATP1B1/HSD11B2/PDPK1/PIK3CA	0.752997760819206
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1111	16/9376	1.58235823582358	HEXB/GBGT1/HEXA	0.85473901381468
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1111	69/9376	1.22307882962209	CREB5/PRKCB/ATF4/CALM2/ATF6B/SIRT1/FOS/PRKACB/CAMK2D/CREB3L2	0.681866390556249
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	14/1111	101/9376	1.16979618753955	ADCY7/MITF/PRKCB/GNAQ/PLCB2/EP300/DVL3/CALM2/CREBBP/PRKACB/CAMK2D/FZD1/MC1R/CREB3L2	0.629003267076163
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	27/1111	205/9376	1.11151017540778	MT-ND2/CTSD/MT-ND4L/NCF2/TGFBR1/CD36/MMP9/PDK4/CYBB/MT-ATP6/MT-ND5/MT-ND3/MT-ND1/MT-ND4/COX4I1/NCF4/MPC1/MT-ATP8/PRKCB/PLCB2/RAC2/MAPK8/PIK3CA/RELA/CAMK2D/NDUFA13/NFKB1	0.591840010248355
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/1111	133/9376	1.14215331307567	ARRB2/GNG11/GNGT1/CREB5/PRKCB/GNAQ/PLCB2/ATF4/CALM2/ARRB1/GNGT2/MAPK8/ATF6B/FOS/PRKACB/CAMK2D/KIF5B/CREB3L2	0.605337485825981
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	21/1111	157/9376	1.12881606632001	IRS2/DDIT3/COX4I1/BID/IL1B/NR1H3/IL6R/PRKAG2/BCL2L11/CASP7/IKBKB/SREBF1/ATF4/MAPK8/MAP3K5/PIK3CA/RELA/FOS/MLXIP/NDUFA13/NFKB1	0.596759292405496
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	20/1111	149/9376	1.13278441938154	MT-ND2/MT-ND4L/MT-ND5/MT-ND3/MT-ND1/GNG11/MT-ND4/GNGT1/ADCY7/DAGLB/MGLL/PTGS2/PRKCB/GNAQ/PLCB2/GNGT2/MAPK8/PRKACB/NDUFA13/GABRE	0.599006081321275
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1111	47/9376	1.25690866959036	ME2/HAGH/ACYP2/ALDH3A2/LDHD/ACSS1/ACSS2	0.647338416729333
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/1111	47/9376	1.25690866959036	IRS2/SOCS2/HK3/IKBKB/SOCS1/MAPK8/PIK3CA	0.647338416729333
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1111	17/9376	1.48927833959867	TXNRD1/SEPHS2/PAPSS2	0.740264572892721
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1111	48/9376	1.23072307230723	ACAA2/IL4I1/BCAT2/HMGCL/BCAT1/ALDH3A2/HADHA	0.587541590850955
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1111	56/9376	1.20560627491321	ARRB2/KIF3A/SMURF2/ARRB1/SPOPL/SPOP/PRKACB/BCL2	0.565774879542924
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	35/1111	275/9376	1.07408559037722	MT-ND2/CCL5/MT-ND4L/C1QB/NCF2/C1QA/C1QC/CYBB/MT-ATP6/MT-ND5/SOD1/MT-ND3/TUBA4A/MT-ND1/DDIT3/MT-ND4/COX4I1/PRNP/IL1B/CREB5/NCF4/MT-ATP8/TUBA1A/RAC2/ATF4/HSPA6/MAPK8/HSPA1B/PIK3CA/PSMD9/ATF6B/PRKACB/KIF5B/NDUFA13/CREB3L2	0.457169000733665
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	30/1111	235/9376	1.07735028822031	MT-ND2/MT-ND4L/MT-ATP6/MT-ND5/MT-ND3/MT-ND1/ACSL3/MT-ND4/ADCY7/PNPLA2/COX4I1/ACSL1/CREB5/MGLL/PRKAG2/ACSL4/SOS2/COX17/MT-ATP8/MAP3K5/RPS6KA3/SLC25A20/PRKACB/NDUFA13/SMARCC2/ARID1B/SOS1/CPT1A/CREB3L2/ACSL5	0.440271173970273
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/1111	49/9376	1.20560627491321	CREB5/ATF4/RELA/ATF6B/PRKACB/NFKB1/CREB3L2	0.529035304557097
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1111	18/9376	1.40654065406541	HEXB/HEXA/MANBA	0.632950798942858
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1111	97/9376	1.13103269089796	GNG11/GNGT1/ADCY7/RPS6KA5/PRKCB/GNAQ/PLCB2/CALM2/GNGT2/PER2/FOS/PRKACB/CAMK2D	0.475593793355111
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/1111	89/9376	1.13787558531134	MAP3K2/TUBA4A/EGFR/ADCY7/PDGFB/SOS2/PRKCB/GNAQ/TUBA1A/PLCB2/PRKACB/SOS1	0.479143817134458
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1111	65/9376	1.16851069722357	SPP1/KISS1/ARRB2/PRKCB/GNAQ/PLCB2/KCNN4/ARRB1/PIK3CA	0.499812633353328
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	16/1111	122/9376	1.10678608844491	MED13L/STAT1/SLC16A10/NOTCH2/PRKCB/PLCB2/ATP1B1/EP300/PDPK1/PIK3CA/CREBBP/MED13/MED12/PRKACB/NCOR1/RXRB	0.435262332605555
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1111	34/9376	1.24106528299889	PRKAG2/NR1D2/SKP1/FBXL3/PER2	0.516268272080634
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/1111	82/9376	1.1320936971746	UCK2/UPP1/CDA/NME3/DPYD/GSTT1/CES2/TK2/RRM2B/GUSB/GSTO1	0.440462487033152
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1111	91/9376	1.11286733068911	ARRB2/GNG11/GNGT1/ADCY7/PRKCB/ARRB1/GNGT2/PDE7A/PRKACB/GRK4/GABRE/PDE4B	0.396660755702825
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1111	75/9376	1.12523252325233	ADCY7/CREB5/PRKCB/GNAQ/PLCB2/ATP1B1/ATF4/ATF6B/PRKACB/CREB3L2	0.39921254411444
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/1111	67/9376	1.13362978088854	BPGM/FBP1/HK3/ALDH3B1/MINPP1/GALM/ALDH3A2/ACSS1/ACSS2	0.40244856318081
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1111	35/9376	1.20560627491321	FBP1/HSD17B14/HK3/ENOSF1/PFKFB3	0.446781250809367
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1111	76/9376	1.1104268321569	ADCY7/SLC4A2/KCNJ2/PRKCB/GNAQ/PLCB2/ATP1B1/CALM2/PRKACB/CAMK2D	0.35437344798756
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/1111	60/9376	1.12523252325233	HSPB1/MAPKAPK3/PTGS2/PRKCB/RAC2/PIK3CA/PLA2G4C/MAPKAPK2	0.35677897629792
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	38/1111	308/9376	1.04120541924322	MT-ND2/CLTB/MT-ND4L/TGM2/MT-ATP6/MT-ND5/SOD1/MT-ND3/TUBA4A/MT-ND1/MT-ND4/COX4I1/BBC3/AP2A2/ULK1/CREB5/SOD2/MT-ATP8/SLC1A3/GNAQ/TUBA1A/PLCB2/EP300/CLTC/AP2S1/AP2M1/MAP2K7/MAPK8/MAP3K5/PSMD9/CREBBP/POLR2C/KIF5B/NDUFA13/POLR2A/TBP/DCTN4/CREB3L2	0.269584661404612
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/1111	69/9376	1.10077094665988	CTSB/KCNJ2/PTGER4/GNAQ/ORAI1/PLCB2/CALM2/KCNMA1/PRKACB	0.308018119820305
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1111	45/9376	1.12523252325233	ABCA1/ABCA5/ABCC3/ABCG1/ABCD1/ABCA12	0.308731207810032
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	16/1111	128/9376	1.05490549054905	NT5E/NME3/ADCY7/NUDT9/ENTPD4/GDA/ENTPD1/AK3/PDE7A/AMPD3/RRM2B/LACC1/PAPSS2/ENPP4/NT5C2/PDE4B	0.229307410010508
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/1111	37/9376	1.14043836816114	CDKN1A/GADD45B/GADD45G/DDB2/RXRB	0.313803430900564
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1111	21/9376	1.20560627491321	DSE/CSGALNACT1/CHST11	0.345816216495263
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1111	46/9376	1.10077094665988	FTL/BLVRA/FTH1/HMOX1/GUSB/BLVRB	0.251185561025155
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1111	30/9376	1.12523252325233	B3GALT4/PGAP3/PIGP/PIGH	0.251875606245972
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1111	22/9376	1.15080598968988	AOC1/ALDH3B1/ALDH3A2	0.259628573675871
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/1111	73/9376	1.04045473040455	CDKN1A/GADD45B/EGFR/GADD45G/PDGFB/MITF/PIK3CA/ARAF/DDB2	0.127215629012932
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/1111	166/9376	1.01677637643282	RGS2/IRS2/GTF2I/ADCY7/CREB5/SLC8A1/PIK3R5/GNAQ/GNA13/PLCB2/ATP1B1/CNGA1/MEF2D/ATF4/CALM2/MEF2A/MEF2C/ATF6B/KCNMA1/CREB3L2	0.0799546322376472
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1111	31/9376	1.0889346999216	DPYD/ALDH3B1/ALDH3A2/HADHA	0.181837594191823
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1111	65/9376	1.03867617530984	LPL/PNPLA2/GK/MGLL/LPIN2/LPIN1/AGPAT3/ALDH3A2	0.114715809430179
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1111	116/9376	1.01852943915081	GLUL/HOMER3/SLC38A1/GNG11/GNGT1/ADCY7/SLC38A2/SLC1A3/PRKCB/GNAQ/PLCB2/GNGT2/PLA2G4C/PRKACB	0.0736218988051991
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	57/1111	480/9376	1.0021602160216	MT-ND2/SQSTM1/MAP1LC3B/MT-ND4L/PINK1/CYBB/MT-ATP6/MT-ND5/SOD1/MT-ND3/TUBA4A/MT-ND1/DDIT3/MT-ND4/OPTN/COX4I1/ULK1/PRNP/BID/IL1B/PTGS2/CASP7/BCL2L1/MT-ATP8/ATXN1/UBC/PRKCB/GNAQ/FRAT1/TUBA1A/PLCB2/DVL3/ATF4/CALM2/PSEN1/MFN2/MAP2K7/MAP1LC3B2/MAPK8/MAP3K5/ATXN2/UBE2L6/RELA/PSMD9/ARAF/LRRK2/CAMK2D/KIF5B/NDUFA13/FIG4/FZD1/RAB5A/BCL2/UBA7/NFKB1/TBK1/DCTN4	0.0178131880653639
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/1111	150/9376	1.01270927092709	CDKN1A/TGFBR1/GADD45B/EGFR/GADD45G/CDKN2B/SOS2/FRAT1/SMAD4/DVL3/GAB1/PIK3CA/ARAF/FZD1/DDB2/BCL2/RXRB/SOS1	0.0575281993756078
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	46/1111	388/9376	1.00052891887127	APOE/MT-ND2/MT-ND4L/LPL/IRS2/SLC39A8/CYBB/MT-ATP6/MT-ND5/MT-ND3/TUBA4A/MT-ND1/DDIT3/MT-ND4/SLC11A2/COX4I1/ULK1/BID/IL1B/SLC39A13/PTGS2/CASP7/MT-ATP8/GNAQ/IKBKB/FRAT1/TUBA1A/PLCB2/DVL3/SLC39A9/ATF4/CALM2/PSEN1/MAP2K7/MAPK8/MAP3K5/PIK3CA/RELA/PSMD9/ARAF/RTN3/KIF5B/SLC39A1/NDUFA13/FZD1/NFKB1	0.00390116781066296
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1111	23/9376	1.10077094665988	POLD4/MLH3/PMS2	0.177396492214818
NA	NA	hsa04081	Hormone signaling	26/1111	219/9376	1.00191937001919	CSH1/CSH2/CSHL1/CCK/CRH/HAMP/STAT5B/IRS2/GH2/GNG11/STAT5A/GNGT1/ADCY7/GNA15/SLC16A10/JAK2/STAT3/GNAQ/GNA13/SMAD4/PLCB2/GNGT2/PIK3CA/PRKACB/IGF2/MC1R	0.0105372041884222
NA	NA	hsa04518	Integrin signaling	18/1111	154/9376	0.986405134019895	SPP1/FN1/ITGB2/FERMT3/FBN1/ITGAX/PARVG/EGFR/ICAM1/ITGAM/ITGAL/PDGFB/LAMB2/LAMB3/PARVB/RAC2/PIK3CA/VEGFB	-0.0623654371405721
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/1111	60/9376	0.984578457845785	CRH/PRKCB/GNAQ/GNA13/PLCB2/ARAF/PLA2G4C	-0.0439349290409991
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1111	16/9376	1.05490549054905	IL4I1/ALDH3B1	0.0805859039299777
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	18/1111	157/9376	0.967556628274292	ITGB2/TGFBR1/SERPINE1/SMAD7/STK3/BBC3/BMPR2/BIRC3/SAV1/YWHAG/DLG5/SMAD4/AMOT/DVL3/YWHAH/LATS1/FZD1/LATS2	-0.150298670867538
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1111	44/9376	0.959004991408232	HEXB/MAN1C1/FUT8/HEXA/MAN1A1	-0.0999289199879116
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1111	26/9376	0.973758914352974	LMBRD1/TCN2/SCARB1	-0.0491228896232911
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1111	17/9376	0.99285222639911	CYP27A1/HSD3B7	-0.0108143834369134
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1111	17/9376	0.99285222639911	GLUL/CA12	-0.0108143834369134
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1111	17/9376	0.99285222639911	LAMP2/PCDH1	-0.0108143834369134
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1111	115/9376	0.954001487105232	DUSP1/ALOX5/GNG11/GNGT1/PTGS2/PTGS1/PRKCB/GNAQ/PLCB2/GNGT2/ARAF/PLA2G4C/PRKACB	-0.18196380438633
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/1111	63/9376	0.937693769376938	ASH1L/KMT2E/KMT2C/EZH1/ALDH3A2/HADHA/KMT2B	-0.181919054534748
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/1111	117/9376	0.937693769376938	BAZ2B/SMARCA1/MEAF6/SRCAP/BCL7B/EPC1/BRD7/KAT5/INO80D/DPF2/SMARCC2/ARID1B/RSF1	-0.248635768407202
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1111	18/9376	0.937693769376938	LMBRD1/TCN2	-0.0970057436018206
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/1111	46/9376	0.917309122216569	PSMB9/PSMB8/PSMB10/PSMD9/PSME1	-0.206118481726662
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1111	28/9376	0.904204706184904	ALPP/CBR1/PCBD1	-0.186116585484986
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/1111	83/9376	0.915098738789542	SOD1/ACSL3/ACSL1/SOD2/ACSL4/HMGCL/ABCD1/ACSL5/DHRS4	-0.284837036133048
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	36/1111	323/9376	0.940596846062315	MARCKS/CDKN1A/TIMP3/CD44/IRS2/MMP9/ZEB2/PLAU/VIM/EGFR/DNMT3A/BMPR2/DICER1/FOXP1/PDGFB/NOTCH2/PTGS2/RPS6KA5/SOS2/BCL2L11/STAT3/BMI1/PRKCB/IKBKB/EP300/ST14/SOCS1/PIK3CA/CREBBP/MIR29A/SIRT1/HMOX1/BCL2/NFKB1/SOS1/ATM	-0.398323329652167
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1111	29/9376	0.873025233557839	GNGT1/CNGA1/CALM2	-0.251073882849177
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1111	48/9376	0.879087908790879	HK3/PRKCB/PLCB2/ATP1B1/PIK3CA	-0.307905411070137
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	41/1111	368/9376	0.940241850271984	MT-ND2/SQSTM1/MAP1LC3B/MT-ND4L/PINK1/CHCHD10/MT-ATP6/MT-ND5/SOD1/MT-ND3/TUBA4A/MT-ND1/PFN2/DDIT3/MT-ND4/OPTN/COX4I1/CASP1/ULK1/ANXA11/BID/NUP214/BCL2L1/MT-ATP8/TUBA1A/SETX/ATF4/ANXA7/MAP1LC3B2/MAP3K5/ATXN2/UBQLN4/PSMD9/UBQLN2/KIF5B/NDUFA13/FIG4/RAB5A/BCL2/TBK1/DCTN4	-0.428773663004513
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/1111	148/9376	0.912350694528912	CDKN1A/GADD45B/EGFR/GADD45G/NOTCH2/SOS2/FRAT1/NFKB2/DVL3/HES1/PIK3CA/ARAF/FOS/FZD1/DDB2/SOS1	-0.394045872345312
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	20/1111	184/9376	0.917309122216569	RHOD/CXCR4/RASA1/PLXNC1/RRAS/BMPR2/ARHGEF12/SEMA3C/SEMA7A/MYL12B/EPHB2/RAC2/PDPK1/SEMA4A/PIK3CA/PAK2/EPHB6/CAMK2D/LIMK2/DPYSL2	-0.415319903540246
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1111	20/9376	0.843924392439244	CYB5R1/NPL	-0.256168758894668
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1111	10/9376	0.843924392439244	PAPSS2	-0.181041940596356
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/1111	78/9376	0.865563479424866	FN1/CLTB/CLTC/GAB1/PIK3CA/HCLS1/ELMO3/ACTR3C	-0.437110292562341
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1111	31/9376	0.816701024941204	HSD17B14/ALDH3A2/GUSB	-0.374776602067574
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1111	31/9376	0.816701024941204	GLUL/ACSS1/ACSS2	-0.374776602067574
NA	NA	hsa04981	Folate transport and metabolism	3/1111	31/9376	0.816701024941204	SLCO2B1/ABCC3/MTHFR	-0.374776602067574
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/1111	134/9376	0.881712051802195	ADCY7/ARHGEF12/PRKCB/GNAQ/GNA13/PLCB2/CALM2/PLA2G2F/ARAF/KCNMA1/PLA2G4C/PRKACB/PPP1R12C/PPP1R12B	-0.5056280451059
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1111	32/9376	0.791179117911791	HK3/GALM/GALT	-0.433814175337843
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1111	32/9376	0.791179117911791	HADHA/ACSS1/ACSS2	-0.433814175337843
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/1111	226/9376	0.896202894625746	CRH/RRAS/ADCY7/NFKBIA/CREB5/ORAI1/ATP1B1/CNGA1/SUCNR1/EP300/RAC2/VAV1/CALM2/MAPK8/PIK3CA/RELA/CREBBP/FOS/PRKACB/CAMK2D/NFKB1/CREB3L2/PDE4B/RAP1A	-0.579095451277847
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1111	42/9376	0.803737516608804	AOC1/IL4I1/ALDH3A2/HADHA	-0.467357563488137
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	16/1111	154/9376	0.87680456357324	ADCY7/CREB5/SLC8A1/PIK3R5/RPS6KA5/GNAQ/PLCB2/ATP1B1/ATF4/CALM2/ATF6B/CACNA2D4/PRKACB/CAMK2D/BCL2/CREB3L2	-0.565149907157769
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1111	43/9376	0.785045946455111	CD36/ABCA1/PLA2G2F/SCARB1	-0.517953143198744
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1111	33/9376	0.767203993126585	OGDH/BCAT2/BCAT1	-0.491145942838789
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/1111	110/9376	0.843924392439244	ADCY7/CPEB4/ANAPC13/ANAPC16/MAPK8/PIK3CA/ARAF/CPEB3/CPEB2/RPS6KA3/PRKACB	-0.603679554781587
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/1111	63/9376	0.803737516608804	POLD4/XPC/POLR2C/DDB2/ERCC1/POLR2A	-0.573038764536535
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1111	63/9376	0.803737516608804	CDKN1A/GADD45B/GADD45G/DVL3/FZD1/DDB2	-0.573038764536535
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1111	12/9376	0.703270327032703	COQ6	-0.377087500749851
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1111	12/9376	0.703270327032703	FCGR2B	-0.377087500749851
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/1111	102/9376	0.827376855332592	CCK/ADCY7/SLC4A2/PRKCB/GNAQ/PLCB2/ATP1B1/PLA2G2F/KCNMA1/RAP1A	-0.642668187657566
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1111	24/9376	0.703270327032703	HS3ST3B1/EXTL1	-0.533624288106604
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1111	13/9376	0.649172609568649	RAD50	-0.464065086830174
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1111	66/9376	0.767203993126585	HSD17B1/HSD3B1/CYP19A1/HSD17B11/STS/HSD11B2	-0.695815169562738
NA	NA	hsa04382	Cornified envelope formation	22/1111	217/9376	0.855591549938404	SPTLC3/S100A7/S100A9/COL17A1/S100A6/TCHH/FURIN/DST/KAZN/CLDN9/S100A8/LAMB3/KRT81/ST14/UGCG/S100A10/KRT27/CLDN1/PLEC/CLDN23/ABCA12/KRT80	-0.789077541611929
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	26/1111	254/9376	0.863859614307887	CXCR4/EGFR/ADCY7/PTAFR/GNA15/PDGFB/SLC8A1/TPCN1/CAMK1/PRKCB/GNAQ/MCOLN1/P2RX7/ITPKC/P2RX4/ORAI1/PLCB2/ORAI3/CALM2/CAMK1D/VEGFB/HRH1/STIM2/PRKACB/CAMK2D/ORAI2	-0.806454815885909
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/1111	144/9376	0.820482048204821	INHBA/KLF4/KAT6A/BMPR2/SKIL/JAK2/STAT3/BMI1/SMAD4/DVL3/PIK3CA/PCGF1/FZD1/TBX3	-0.79590726949925
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	14/1111	144/9376	0.820482048204821	RBPJ/ULK1/ATXN1/PRKCB/GNAQ/PLCB2/PUM2/MAPK8/MAP3K5/ATXN2/KAT5/PIK3CA/PSMD9/TBP	-0.79590726949925
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1111	14/9376	0.602803137456603	FUT8	-0.545263902478217
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1111	26/9376	0.649172609568649	PLA2G2F/PLA2G4C	-0.656743223538829
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/1111	59/9376	0.715190163084105	GPX4/ANPEP/GSTT1/RRM2B/GSTO1	-0.804570642691186
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1111	27/9376	0.625129179584625	HMGCL/HADHA	-0.71515829049505
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/1111	138/9376	0.79500123925436	ADCY7/CPEB4/ANAPC13/YWHAG/SKP1/ANAPC16/YWHAH/CALM2/CPEB3/CPEB2/RPS6KA3/PRKACB/CAMK2D	-0.889453070387164
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1111	15/9376	0.562616261626163	ALPP	-0.62153899018555
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1111	90/9376	0.75015501550155	AQP9/ADCY7/SLC4A2/ABCC3/NCEH1/ATP1B1/SCARB1/PRKACB	-0.873169966670707
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	23/1111	233/9376	0.833058413137451	FN1/FBLN1/FBN1/FMNL1/ANK3/VIM/FBN2/PDLIM4/FMNL2/BGN/DIAPH2/PDLIM5/SDC2/FHL1/SGCE/ATP1B1/FMNL3/AMPD3/TRIM55/TMEM43/CSRP1/PLEC/SYNE1	-0.946061516334824
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/1111	50/9376	0.675139513951395	SAT1/AOC1/AMD1/ALDH3A2	-0.844413999960813
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	17/1111	178/9376	0.805995206262199	MMP7/TLE2/PRKCB/FRAT1/SKP1/SMAD4/PLCB2/EP300/DVL3/RAC2/PSEN1/MAPK8/CREBBP/SIRT1/PRKACB/CAMK2D/FZD1	-0.958069464208493
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1111	103/9376	0.737409663296427	SLC7A7/COL17A1/SLC7A8/SLC38A2/SLC8A1/SLC16A10/ATP1B1/KCNN4/COL8A2	-0.982445485274721
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1111	41/9376	0.617505653004325	BPGM/SDS/SDSL	-0.899872597109684
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1111	41/9376	0.617505653004325	POLD4/RAD50/ATM	-0.899872597109684
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1111	17/9376	0.496426113199555	CDO1	-0.761893339766548
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1111	30/9376	0.562616261626163	PLA2G2F/PLA2G4C	-0.879693959715806
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1111	54/9376	0.625129179584625	HES1/PMS2/WDR48/ERCC1	-1.01285017157592
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1111	19/9376	0.44417073286276	OGDH	-0.88914202032965
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/1111	89/9376	0.663760758098282	SPP1/FN1/CD44/CD36/LAMB2/LAMB3/CD47	-1.16849515794538
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1111	20/9376	0.421962196219622	LIPA	-0.948740351569525
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/1111	34/9376	0.496426113199555	POLR2C/POLR2A	-1.07845981457476
Cellular Processes	Cell motility	hsa04814	Motor proteins	17/1111	194/9376	0.739521374817894	DYNLRB1/TUBA4A/KIFC3/DYNLT1/DYNLT3/KIF3A/MYO1F/TUBA1A/MYL12B/MYO5B/MYO5A/MYO1G/KIF2A/KIF1B/KIF5B/DCTN4/DYNC1LI2	-1.34408133588263
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1111	36/9376	0.468846884688469	GALNT7/B4GALT5	-1.17062766663821
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1111	49/9376	0.516688403534231	GALNT7/MFNG/LFNG	-1.24358508873419
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1111	37/9376	0.456175347264456	GLUL/IL4I1	-1.21515255461322
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1111	37/9376	0.456175347264456	IL4I1/ALDH3B1	-1.21515255461322
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/1111	37/9376	0.456175347264456	HK3/GALT	-1.21515255461322
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/1111	158/9376	0.694368170994315	CDKN1A/GADD45B/ANAPC13/GADD45G/YWHAG/CDKN2B/SKP1/SMAD4/ANAPC16/EP300/YWHAH/CREBBP/ATM	-1.42046327780094
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1111	23/9376	0.366923648886628	GLUL	-1.11446332215888
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1111	23/9376	0.366923648886628	ATP1B1	-1.11446332215888
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/1111	75/9376	0.562616261626163	GLUL/SDS/SDSL/BCAT2/BCAT1	-1.39427898133692
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1111	26/9376	0.324586304784325	HES1	-1.26436355745437
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/1111	27/9376	0.312564589792313	ACOT2	-1.31145212168061
NA	NA	hsa04082	Neuroactive ligand signaling	16/1111	199/9376	0.678532174825523	GNG11/GNGT1/ADCY7/P2RY11/SLC1A3/PRKCB/GNAQ/P2RX4/TAC3/PLCB2/GNGT2/HRH1/PRKACB/GABRE/OGFR/SLC6A2	-1.68048609450981
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/1111	56/9376	0.452102353092452	MAN1C1/FUT8/MAN1A1	-1.50767152078324
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1111	28/9376	0.301401568728301	ST3GAL6	-1.35727705897977
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	8/1111	116/9376	0.582016822371892	FBP1/SDS/OGDH/SDSL/ME2/HK3/ACSS1/ACSS2	-1.66074725495748
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1111	70/9376	0.482242509965282	PTGS2/GSTT1/CBR1/GSTO1	-1.59409839629441
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/1111	44/9376	0.383601996563293	GTF2I/TBP	-1.50252406041704
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/1111	71/9376	0.475450361937602	EGFR/HK3/PIK3CA/SCO2	-1.62659268933144
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1111	30/9376	0.281308130813081	OGDH	-1.4454787426967
NA	NA	hsa04519	Cadherin signaling	36/1111	404/9376	0.752011834846851	PCDH1/MRAS/STK3/VIM/RRAS/NCKAP1L/EGFR/LHFPL2/AMOTL2/NFKBIA/AMOTL1/SAV1/YWHAG/MYO1F/IKBKB/KRT81/EP300/DVL3/RAC2/VAV1/YWHAH/PSEN1/MAPK8/MYO1G/RELA/CREBBP/KRT27/LATS1/TMC5/TMC8/FZD1/KRT80/ACTR3C/GABRE/LATS2/NFKB1	-1.86809192906923
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/1111	31/9376	0.272233674980401	FBP1	-1.48800499458637
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/1111	31/9376	0.272233674980401	TMEM208	-1.48800499458637
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/1111	191/9376	0.618583324301016	CRH/GNG11/GNGT1/CREB5/SOS2/ATF4/CALM2/GNGT2/SLC29A3/ARAF/ATF6B/PRKACB/SOS1/CREB3L2	-1.95253136353867
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/1111	78/9376	0.432781739712433	CNOT6L/BTG2/XRN1/CNOT4	-1.844267752842
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1111	79/9376	0.427303489842655	GSTT1/ALDH3B1/CBR1/GSTO1	-1.87407904892447
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1111	36/9376	0.234423442344234	GUSB	-1.68728201621455
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/1111	36/9376	0.234423442344234	HK3	-1.68728201621455
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1111	36/9376	0.234423442344234	POLD4	-1.68728201621455
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1111	68/9376	0.372319584899666	ALDH1A1/DHRS4L2/DHRS4	-1.90452240344262
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/1111	154/9376	0.548002852233275	ALPP/NME3/BCAT2/AK3/PNPO/BCAT1/ALDH3A2/COQ6/GUSB/NADK	-2.07350331720936
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/1111	108/9376	0.468846884688469	NUP214/KPNA3/SUMO3/KPNA6/DDX19A/XPOT	-2.03544718024031
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/1111	39/9376	0.216390869856216	MTHFR	-1.79783301030905
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1111	73/9376	0.346818243468182	GSTT1/ALDH3B1/GSTO1	-2.05402253793358
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/1111	87/9376	0.388011214914595	COX4I1/SLC8A1/ATP1B1/CACNA2D4	-2.10251860346183
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1111	41/9376	0.205835217668108	GABRE	-1.86838611033937
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/1111	44/9376	0.191800998281646	POLD4	-1.97005577389342
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/1111	105/9376	0.401868758304402	ADCY7/SLC8A1/SGCE/CACNA2D4/PRKACB	-2.25969115077004
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/1111	99/9376	0.340979552500705	PRKAG2/SLC8A1/SGCE/CACNA2D4	-2.41676235470026
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1111	86/9376	0.294392229920666	SCNN1B/PLCB2/PRKACB	-2.4100494958804
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/1111	86/9376	0.294392229920666	SLC8A1/SGCE/CACNA2D4	-2.4100494958804
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	26/1111	370/9376	0.593027951443793	CSH1/CSH2/CSHL1/CCK/CRH/KISS1/C5AR1/FPR3/GH2/C3AR1/NR3C1/PTGER4/PTAFR/FPR1/P2RY11/NPFFR2/P2RX7/P2RX4/TAC3/UTS2/GPR35/HRH1/S1PR4/GABRE/MC1R/OGFR	-2.92833468582835
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/1111	103/9376	0.163868814065873	SYMPK/DDX19A	-3.12826937590504
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/1111	183/9376	0.138348261055614	SBDS/REXO2/XRN1	-4.31568682990425
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/1111	243/9376	0.173646994329063	HSPA6/HSPA1B/SART1/SLU7/SNRNP27	-4.78501449577147
Genetic Information Processing	Translation	hsa03010	Ribosome	1/1111	222/9376	0.038014612272038	RPS4Y1	-5.318152015694
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1111	449/9376	0.131569504389192	RGS2/ARRB2/SLC8A1/CALM2/ARRB1/PRKACB/CAMK2D	-6.91395752955938