ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 99/2065 489/18639 0.202453987730061 1.82738008585986 1.57333742139388e-09 7.40096354205915e-07 GO:0023023 MHC protein complex binding 19/2065 37/18639 0.513513513513513 4.63505006216871 1.5879115053111e-09 7.40096354205915e-07 GO:0060589 nucleoside-triphosphatase regulator activity 99/2065 490/18639 0.202040816326531 1.82365073874586 1.76213417668075e-09 7.40096354205915e-07 GO:0005096 GTPase activator activity 64/2065 271/18639 0.236162361623616 2.13163692896009 2.87601012247554e-09 7.51453050284487e-07 GO:0140375 immune receptor activity 44/2065 156/18639 0.282051282051282 2.54583721363382 2.98195654874796e-09 7.51453050284487e-07 GO:0023026 MHC class II protein complex binding 15/2065 27/18639 0.555555555555556 5.01452784503632 2.09744511559779e-08 4.40463474275536e-06 GO:0140313 molecular sequestering activity 22/2065 55/18639 0.4 3.61046004842615 2.92220567718905e-08 5.2599702189403e-06 GO:0042277 peptide binding 55/2065 249/18639 0.220883534136546 1.99372793838793 3.8819775404134e-07 6.11411462615111e-05 GO:0005543 phospholipid binding 92/2065 497/18639 0.185110663983903 1.6708366421288 4.67748980594186e-07 6.5484857283186e-05 GO:0038187 pattern recognition receptor activity 18/2065 48/18639 0.375 3.38480629539952 1.62204262898483e-06 0.000204377371252089 GO:0001540 amyloid-beta binding 25/2065 83/18639 0.301204819277108 2.71871991598355 1.98849864149603e-06 0.000227773480753181 GO:0031267 small GTPase binding 58/2065 283/18639 0.204946996466431 1.84988235696746 2.50471369562126e-06 0.00025950201763626 GO:0046332 SMAD binding 24/2065 79/18639 0.30379746835443 2.7421215557667 2.677401769263e-06 0.00025950201763626 GO:0140311 protein sequestering activity 14/2065 33/18639 0.424242424242424 3.82927580893683 4.25041325356524e-06 0.000382537192820872 GO:0003779 actin binding 80/2065 443/18639 0.18058690744921 1.63000453653551 6.80230805036389e-06 0.000571393876230567 GO:0003712 transcription coregulator activity 87/2065 495/18639 0.175757575757576 1.5864142637024 8.25831787665669e-06 0.000650342532786715 GO:0042605 peptide antigen binding 16/2065 45/18639 0.355555555555556 3.20929782082324 1.35333025608119e-05 0.00100305654274253 GO:0004674 protein serine/threonine kinase activity 77/2065 433/18639 0.177829099307159 1.60511214624026 1.76359691842986e-05 0.00116845108184086 GO:0032395 MHC class II receptor activity 7/2065 10/18639 0.7 6.31830508474576 1.79694097633755e-05 0.00116845108184086 GO:0051020 GTPase binding 60/2065 315/18639 0.19047619047619 1.71926668972674 1.85468425689026e-05 0.00116845108184086 GO:0005126 cytokine receptor binding 54/2065 275/18639 0.196363636363636 1.77240766013647 1.98227751747807e-05 0.00118936651048684 GO:0035091 phosphatidylinositol binding 55/2065 284/18639 0.193661971830986 1.74802203048801 2.51088571434379e-05 0.00143805272730599 GO:0106310 protein serine kinase activity 66/2065 361/18639 0.182825484764543 1.65021027144132 2.83871347863443e-05 0.00155512129699103 GO:0019864 IgG binding 7/2065 11/18639 0.636363636363636 5.74391371340524 4.46640249235564e-05 0.00231105734281685 GO:0019902 phosphatase binding 40/2065 190/18639 0.210526315789474 1.90024213075061 4.58543123574771e-05 0.00231105734281685 GO:0061578 K63-linked deubiquitinase activity 8/2065 15/18639 0.533333333333333 4.81394673123487 7.02426452174339e-05 0.00335793726710563 GO:0005484 SNAP receptor activity 13/2065 36/18639 0.361111111111111 3.25944309927361 7.1955798580835e-05 0.00335793726710563 GO:0019955 cytokine binding 32/2065 144/18639 0.222222222222222 2.00581113801453 8.74495846175294e-05 0.00393523130778882 GO:0051019 mitogen-activated protein kinase binding 11/2065 28/18639 0.392857142857143 3.5459875475614 0.000107073274592738 0.00453541609644315 GO:0004842 ubiquitin-protein transferase activity 76/2065 449/18639 0.169265033407572 1.52781160178389 0.000107986097534361 0.00453541609644315 GO:0019787 ubiquitin-like protein transferase activity 80/2065 479/18639 0.167014613778706 1.50749897637835 0.000113725347217635 0.0046223850804587 GO:0140297 DNA-binding transcription factor binding 81/2065 488/18639 0.165983606557377 1.49819295042274 0.000127517193275714 0.00502098948523124 GO:0016755 aminoacyltransferase activity 82/2065 496/18639 0.165322580645161 1.49222643130516 0.000133077836756949 0.0050811537670835 GO:0035325 Toll-like receptor binding 7/2065 13/18639 0.538461538461538 4.86023468057366 0.000189840393242694 0.00703526163193512 GO:0005085 guanyl-nucleotide exchange factor activity 44/2065 230/18639 0.191304347826087 1.72674176229077 0.000206489152598287 0.00743360949353833 GO:0008429 phosphatidylethanolamine binding 8/2065 17/18639 0.470588235294118 4.24760005697194 0.00021632261603628 0.00748823282503104 GO:0140996 histone H3 kinase activity 62/2065 357/18639 0.173669467787115 1.56756668769203 0.000219892551211229 0.00748823282503104 GO:0046915 transition metal ion transmembrane transporter activity 14/2065 45/18639 0.311111111111111 2.80813559322034 0.000240137558594768 0.00796245589024759 GO:0140857 histone H3T45 kinase activity 46/2065 246/18639 0.186991869918699 1.68781668930491 0.000258304002768951 0.00817398228093089 GO:0005131 growth hormone receptor binding 6/2065 10/18639 0.6 5.41569007263922 0.000259491500981933 0.00817398228093089 GO:0035173 histone kinase activity 62/2065 360/18639 0.172222222222222 1.55450363196126 0.000277714758581941 0.00852050275726289 GO:0035403 histone H3T6 kinase activity 46/2065 247/18639 0.186234817813765 1.6809834233563 0.00028401675857543 0.00852050275726289 GO:0141003 histone H2AX kinase activity 61/2065 354/18639 0.172316384180791 1.55535355193499 0.000305063248339801 0.00893472167348831 GO:0004679 AMP-activated protein kinase activity 46/2065 248/18639 0.185483870967742 1.67420526439116 0.00031200615367737 0.00893472167348831 GO:0002020 protease binding 29/2065 136/18639 0.213235294117647 1.92469377581541 0.000384248725614624 0.00899204311692862 GO:0044389 ubiquitin-like protein ligase binding 56/2065 322/18639 0.173913043478261 1.56976523844615 0.000416975500875672 0.00899204311692862 GO:0004676 3-phosphoinositide-dependent protein kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0004711 ribosomal protein S6 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0035175 histone H3S10 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0035979 histone H2AXS139 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0044022 histone H3S28 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0044023 histone H4S1 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0044024 histone H2AS1 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0044025 histone H2BS14 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0072354 histone H3T3 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0072371 histone H2AS121 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0072518 Rho-dependent protein serine/threonine kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0140823 histone H2BS36 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0140855 histone H3S57 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0140995 histone H2A kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0140997 histone H4 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0140998 histone H2B kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:1990244 histone H2AT120 kinase activity 45/2065 245/18639 0.183673469387755 1.65786430795078 0.000449602155846431 0.00899204311692862 GO:0004677 DNA-dependent protein kinase activity 45/2065 246/18639 0.182926829268293 1.65112502214611 0.00049243010056527 0.00969471760487875 GO:0035402 histone H3T11 kinase activity 45/2065 247/18639 0.182186234817814 1.64444030545725 0.000538858815364987 0.0104455708824597 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 59/2065 349/18639 0.169054441260745 1.52591076545231 0.000623863702844095 0.0119101252361145 GO:0003713 transcription coactivator activity 46/2065 256/18639 0.1796875 1.62188634987893 0.000641172529684023 0.0120578714537592 GO:0042625 ATPase-coupled ion transmembrane transporter activity 9/2065 24/18639 0.375 3.38480629539952 0.000683100023102981 0.0122958004158537 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 9/2065 24/18639 0.375 3.38480629539952 0.000683100023102981 0.0122958004158537 GO:0046961 proton-transporting ATPase activity, rotational mechanism 9/2065 24/18639 0.375 3.38480629539952 0.000683100023102981 0.0122958004158537 GO:0001221 transcription coregulator binding 25/2065 115/18639 0.217391304347826 1.96220654805769 0.00069792473587032 0.0123306523040402 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 44/2065 243/18639 0.181069958847737 1.6343646309748 0.000704608703088013 0.0123306523040402 GO:0031625 ubiquitin protein ligase binding 52/2065 302/18639 0.172185430463576 1.5541715440245 0.000830541600474147 0.0143353755698278 GO:0003714 transcription corepressor activity 38/2065 204/18639 0.186274509803922 1.68134168921806 0.000913445919879404 0.0155532683655142 GO:0019903 protein phosphatase binding 29/2065 144/18639 0.201388888888889 1.81776634382567 0.0010164123812998 0.0170757280058367 GO:0043130 ubiquitin binding 22/2065 100/18639 0.22 1.98575302663438 0.00120386544919233 0.0197735453871255 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 12/2065 41/18639 0.292682926829268 2.64180003543377 0.00120838332921323 0.0197735453871255 GO:0019865 immunoglobulin binding 9/2065 26/18639 0.346153846153846 3.12443658036878 0.001329720312776 0.020943094926222 GO:0050750 low-density lipoprotein particle receptor binding 9/2065 26/18639 0.346153846153846 3.12443658036878 0.001329720312776 0.020943094926222 GO:0070412 R-SMAD binding 9/2065 26/18639 0.346153846153846 3.12443658036878 0.001329720312776 0.020943094926222 GO:0004896 cytokine receptor activity 21/2065 96/18639 0.21875 1.97447033898305 0.00165865082342774 0.0258012350310981 GO:1901981 phosphatidylinositol phosphate binding 34/2065 185/18639 0.183783783783784 1.65886002224985 0.00208118782459218 0.0319792275486115 GO:0019763 immunoglobulin receptor activity 6/2065 14/18639 0.428571428571429 3.86835005188516 0.00250512585150589 0.03802962136021 GO:0005381 iron ion transmembrane transporter activity 5/2065 10/18639 0.5 4.51307506053269 0.00259076589990902 0.0388614884986354 GO:0000149 SNARE binding 22/2065 106/18639 0.207547169811321 1.87335191191923 0.00263995997100918 0.039133524276136 GO:0141110 transporter inhibitor activity 12/2065 45/18639 0.266666666666667 2.40697336561743 0.00289590306988871 0.0423574772623946 GO:0052866 phosphatidylinositol phosphate phosphatase activity 10/2065 34/18639 0.294117647058824 2.65475003560746 0.00292468295383201 0.0423574772623946 GO:0019887 protein kinase regulator activity 43/2065 255/18639 0.168627450980392 1.52205668708161 0.00332474612344346 0.0476043194947586 GO:0019207 kinase regulator activity 47/2065 287/18639 0.163763066202091 1.47815001982604 0.00398331602764376 0.0563930134250689 GO:0140031 phosphorylation-dependent protein binding 5/2065 11/18639 0.454545454545455 4.10279550957517 0.00431866708962322 0.0602103665013593 GO:0001786 phosphatidylserine binding 14/2065 59/18639 0.23728813559322 2.14179833381212 0.00434852646954261 0.0602103665013593 GO:0140030 modification-dependent protein binding 31/2065 173/18639 0.179190751445087 1.61740262284986 0.00470869545425479 0.064488655134359 GO:0140693 molecular condensate scaffold activity 12/2065 48/18639 0.25 2.25653753026634 0.00513230014532479 0.0683333269371148 GO:0030295 protein kinase activator activity 26/2065 139/18639 0.18705035971223 1.68834462696187 0.00514996773442303 0.0683333269371148 GO:0070325 lipoprotein particle receptor binding 9/2065 31/18639 0.290322580645161 2.62049519643833 0.00515211591986183 0.0683333269371148 GO:0001216 DNA-binding transcription activator activity 73/2065 491/18639 0.14867617107943 1.34197343958813 0.00545830045688272 0.0706780026901913 GO:0005159 insulin-like growth factor receptor binding 6/2065 16/18639 0.375 3.38480629539952 0.00549717798701488 0.0706780026901913 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 6/2065 16/18639 0.375 3.38480629539952 0.00549717798701488 0.0706780026901913 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 72/2065 484/18639 0.148760330578512 1.34273307586097 0.00568016773056122 0.0722930438435064 GO:0048306 calcium-dependent protein binding 17/2065 80/18639 0.2125 1.91805690072639 0.00598655451178557 0.0754305868484982 GO:0001222 transcription corepressor binding 12/2065 49/18639 0.244897959183673 2.21048574393438 0.0061259072767008 0.0764222095905248 GO:0019209 kinase activator activity 27/2065 148/18639 0.182432432432432 1.64666252208625 0.00625129879595355 0.0772219263029556 GO:0071813 lipoprotein particle binding 9/2065 32/18639 0.28125 2.53860472154964 0.00647628035877885 0.0784626274236668 GO:0071814 protein-lipid complex binding 9/2065 32/18639 0.28125 2.53860472154964 0.00647628035877885 0.0784626274236668 GO:0004875 complement receptor activity 5/2065 12/18639 0.416666666666667 3.76089588377724 0.00673366859291346 0.0808040231149615 GO:0005385 zinc ion transmembrane transporter activity 8/2065 27/18639 0.296296296296296 2.67441485068604 0.00718628522216772 0.083731168913661 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 8/2065 27/18639 0.296296296296296 2.67441485068604 0.00718628522216772 0.083731168913661 GO:0016248 channel inhibitor activity 11/2065 44/18639 0.25 2.25653753026634 0.00723280322214798 0.083731168913661 GO:0003725 double-stranded RNA binding 16/2065 75/18639 0.213333333333333 1.92557869249395 0.00724341064411829 0.083731168913661 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 6/2065 17/18639 0.352941176470588 3.18570004272896 0.00770971276580544 0.0875156584226563 GO:0036041 long-chain fatty acid binding 6/2065 17/18639 0.352941176470588 3.18570004272896 0.00770971276580544 0.0875156584226563 GO:0008238 exopeptidase activity 20/2065 102/18639 0.196078431372549 1.76983335707164 0.00778292806767291 0.0875579407613203 GO:0005507 copper ion binding 14/2065 63/18639 0.222222222222222 2.00581113801453 0.00803301153696596 0.089571633067054 GO:0003924 GTPase activity 51/2065 331/18639 0.154078549848943 1.39073612137261 0.00938372701917448 0.10371487758035 GO:0051427 hormone receptor binding 9/2065 34/18639 0.264705882352941 2.38927503204672 0.00989068918280702 0.106499797204807 GO:0008035 high-density lipoprotein particle binding 5/2065 13/18639 0.384615384615385 3.47159620040976 0.0099555505308269 0.106499797204807 GO:0032396 inhibitory MHC class I receptor activity 5/2065 13/18639 0.384615384615385 3.47159620040976 0.0099555505308269 0.106499797204807 GO:0042578 phosphoric ester hydrolase activity 55/2065 363/18639 0.151515151515152 1.36759850319172 0.0100295919289061 0.106499797204807 GO:0061791 GTPase motor activity 10/2065 40/18639 0.25 2.25653753026634 0.0102247359656928 0.106499797204807 GO:1990606 membrane scission GTPase motor activity 10/2065 40/18639 0.25 2.25653753026634 0.0102247359656928 0.106499797204807 GO:0022804 active transmembrane transporter activity 67/2065 457/18639 0.146608315098468 1.32330866107523 0.0102273614776044 0.106499797204807 GO:0032393 MHC class I receptor activity 6/2065 18/18639 0.333333333333333 3.00871670702179 0.0104975695579457 0.107536078398469 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 6/2065 18/18639 0.333333333333333 3.00871670702179 0.0104975695579457 0.107536078398469 GO:0038024 cargo receptor activity 14/2065 65/18639 0.215384615384615 1.94409387222947 0.0106294801496891 0.108009233779099 GO:0016791 phosphatase activity 43/2065 273/18639 0.157509157509158 1.42170130112019 0.0111661370890067 0.112554661857187 GO:0032182 ubiquitin-like protein binding 22/2065 120/18639 0.183333333333333 1.65479418886199 0.0120072236009679 0.119696056589638 GO:0001784 phosphotyrosine residue binding 11/2065 47/18639 0.234042553191489 2.11250321982381 0.012064602529273 0.119696056589638 GO:0042169 SH2 domain binding 10/2065 41/18639 0.24390243902439 2.20150002952814 0.012212801646428 0.120219766207026 GO:0015245 fatty acid transmembrane transporter activity 6/2065 19/18639 0.315789473684211 2.85036319612591 0.0139308509046705 0.134540082911868 GO:1990380 K48-linked deubiquitinase activity 6/2065 19/18639 0.315789473684211 2.85036319612591 0.0139308509046705 0.134540082911868 GO:0005545 1-phosphatidylinositol binding 5/2065 14/18639 0.357142857142857 3.22362504323763 0.0140946753526719 0.134540082911868 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 5/2065 14/18639 0.357142857142857 3.22362504323763 0.0140946753526719 0.134540082911868 GO:0035591 signaling adaptor activity 23/2065 129/18639 0.178294573643411 1.60931358747677 0.0143477709385611 0.13588990405118 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 22/2065 122/18639 0.180327868852459 1.62766641527408 0.0144517834467128 0.13588990405118 GO:0015101 organic cation transmembrane transporter activity 16/2065 81/18639 0.197530864197531 1.78294323379069 0.0151169161237147 0.141091217154671 GO:0016922 nuclear receptor binding 24/2065 137/18639 0.175182481751825 1.58122337887277 0.0154594962099602 0.142601273486859 GO:0004197 cysteine-type endopeptidase activity 17/2065 88/18639 0.193181818181818 1.74368809156945 0.0155050591013489 0.142601273486859 GO:0061659 ubiquitin-like protein ligase activity 55/2065 372/18639 0.147849462365591 1.33451144263063 0.0159122522292307 0.145285781223411 GO:0061134 peptidase regulator activity 36/2065 226/18639 0.15929203539823 1.43779382459448 0.0161225703018676 0.146147040146426 GO:0008200 ion channel inhibitor activity 10/2065 43/18639 0.232558139534884 2.09910467931753 0.0170435889072161 0.153288578856647 GO:0043394 proteoglycan binding 9/2065 37/18639 0.243243243243243 2.19555002944833 0.0173368723245411 0.153288578856647 GO:0170055 lipid transmembrane transporter activity 12/2065 56/18639 0.214285714285714 1.93417502594258 0.0179745846815969 0.153288578856647 GO:0016004 phospholipase activator activity 6/2065 20/18639 0.3 2.70784503631961 0.0180750617197658 0.153288578856647 GO:0004090 carbonyl reductase (NADPH) activity 4/2065 10/18639 0.4 3.61046004842615 0.0182089470077138 0.153288578856647 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 4/2065 10/18639 0.4 3.61046004842615 0.0182089470077138 0.153288578856647 GO:0008140 cAMP response element binding protein binding 4/2065 10/18639 0.4 3.61046004842615 0.0182089470077138 0.153288578856647 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 4/2065 10/18639 0.4 3.61046004842615 0.0182089470077138 0.153288578856647 GO:0015279 store-operated calcium channel activity 4/2065 10/18639 0.4 3.61046004842615 0.0182089470077138 0.153288578856647 GO:0045322 unmethylated CpG binding 4/2065 10/18639 0.4 3.61046004842615 0.0182089470077138 0.153288578856647 GO:0140767 enzyme-substrate adaptor activity 24/2065 139/18639 0.172661870503597 1.55847196334942 0.018248640340077 0.153288578856647 GO:0032813 tumor necrosis factor receptor superfamily binding 11/2065 50/18639 0.22 1.98575302663438 0.019029235624441 0.158786999250302 GO:0047372 monoacylglycerol lipase activity 5/2065 15/18639 0.333333333333333 3.00871670702179 0.019248524681177 0.159560138804494 GO:0016504 peptidase activator activity 12/2065 57/18639 0.210526315789474 1.90024213075061 0.0205416512125914 0.169166539397812 GO:0005525 GTP binding 55/2065 378/18639 0.145502645502645 1.31332872131904 0.0212157985655804 0.173583806445658 GO:0042826 histone deacetylase binding 22/2065 127/18639 0.173228346456693 1.56358506034203 0.0222994732693619 0.18127313754449 GO:0033218 amide binding 38/2065 247/18639 0.153846153846154 1.3886384801639 0.0229140876707783 0.184502688913629 GO:0140312 cargo adaptor activity 6/2065 21/18639 0.285714285714286 2.57890003459011 0.0229896207614601 0.184502688913629 GO:0004715 non-membrane spanning protein tyrosine kinase activity 10/2065 45/18639 0.222222222222222 2.00581113801453 0.0231557415748257 0.184659711292914 GO:0005044 scavenger receptor activity 7/2065 27/18639 0.259259259259259 2.34011299435028 0.0245157358456395 0.187183379379231 GO:0019239 deaminase activity 8/2065 33/18639 0.242424242424242 2.18815760510676 0.0247255991566377 0.187183379379231 GO:0005149 interleukin-1 receptor binding 5/2065 16/18639 0.3125 2.82067191283293 0.0254991368148871 0.187183379379231 GO:0005324 long-chain fatty acid transmembrane transporter activity 5/2065 16/18639 0.3125 2.82067191283293 0.0254991368148871 0.187183379379231 GO:0022858 alanine transmembrane transporter activity 5/2065 16/18639 0.3125 2.82067191283293 0.0254991368148871 0.187183379379231 GO:0140789 histone phosphatase activity 23/2065 136/18639 0.169117647058824 1.52648127047429 0.0256301268569064 0.187183379379231 GO:0030246 carbohydrate binding 42/2065 280/18639 0.15 1.35392251815981 0.0257310894954442 0.187183379379231 GO:0016209 antioxidant activity 16/2065 86/18639 0.186046511627907 1.67928374345402 0.0257429834778236 0.187183379379231 GO:0008432 JUN kinase binding 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0016176 superoxide-generating NADPH oxidase activator activity 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0032050 clathrin heavy chain binding 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0032794 GTPase activating protein binding 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0042608 T cell receptor binding 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0047676 arachidonate-CoA ligase activity 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0050786 RAGE receptor binding 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0140537 transcription regulator activator activity 4/2065 11/18639 0.363636363636364 3.28223640766014 0.0261462498180514 0.187183379379231 GO:0004879 nuclear receptor activity 12/2065 59/18639 0.203389830508475 1.83582714326753 0.0264770573713723 0.187421866786119 GO:0031593 polyubiquitin modification-dependent protein binding 12/2065 59/18639 0.203389830508475 1.83582714326753 0.0264770573713723 0.187421866786119 GO:0019001 guanyl nucleotide binding 57/2065 400/18639 0.1425 1.28622639225182 0.0279282775295068 0.195497942706548 GO:0032561 guanyl ribonucleotide binding 57/2065 400/18639 0.1425 1.28622639225182 0.0279282775295068 0.195497942706548 GO:0005246 calcium channel regulator activity 11/2065 53/18639 0.207547169811321 1.87335191191923 0.0285969183515608 0.19750311272428 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 6/2065 22/18639 0.272727272727273 2.4616773057451 0.0287266220726902 0.19750311272428 GO:0033691 sialic acid binding 6/2065 22/18639 0.272727272727273 2.4616773057451 0.0287266220726902 0.19750311272428 GO:0061630 ubiquitin protein ligase activity 51/2065 353/18639 0.144475920679887 1.30406134893579 0.0288417243978314 0.19750311272428 GO:0036408 histone H3K14 acetyltransferase activity 7/2065 28/18639 0.25 2.25653753026634 0.0296534915161917 0.200878490916137 GO:0046966 nuclear thyroid hormone receptor binding 7/2065 28/18639 0.25 2.25653753026634 0.0296534915161917 0.200878490916137 GO:0098531 ligand-modulated transcription factor activity 12/2065 60/18639 0.2 1.80523002421308 0.0298729091076266 0.201282703078126 GO:0005504 fatty acid binding 10/2065 47/18639 0.212765957446809 1.9204574725671 0.0307104764708265 0.201391266807823 GO:0033192 calmodulin-dependent protein phosphatase activity 15/2065 81/18639 0.185185185185185 1.67150928167877 0.0313275303923281 0.201391266807823 GO:0140791 histone H2AXS140 phosphatase activity 15/2065 81/18639 0.185185185185185 1.67150928167877 0.0313275303923281 0.201391266807823 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 15/2065 81/18639 0.185185185185185 1.67150928167877 0.0313275303923281 0.201391266807823 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 15/2065 81/18639 0.185185185185185 1.67150928167877 0.0313275303923281 0.201391266807823 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 15/2065 81/18639 0.185185185185185 1.67150928167877 0.0313275303923281 0.201391266807823 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 15/2065 81/18639 0.185185185185185 1.67150928167877 0.0313275303923281 0.201391266807823 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 15/2065 81/18639 0.185185185185185 1.67150928167877 0.0313275303923281 0.201391266807823 GO:1990439 MAP kinase serine/threonine phosphatase activity 15/2065 81/18639 0.185185185185185 1.67150928167877 0.0313275303923281 0.201391266807823 GO:0070851 growth factor receptor binding 23/2065 139/18639 0.165467625899281 1.49353563154319 0.0321584456745304 0.205288910953097 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/2065 54/18639 0.203703703703704 1.83866020984665 0.0324410273547215 0.205288910953097 GO:0001530 lipopolysaccharide binding 9/2065 41/18639 0.219512195121951 1.98135002657533 0.0327081717949642 0.205288910953097 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 5/2065 17/18639 0.294117647058824 2.65475003560746 0.0329113968353378 0.205288910953097 GO:0030169 low-density lipoprotein particle binding 5/2065 17/18639 0.294117647058824 2.65475003560746 0.0329113968353378 0.205288910953097 GO:0070403 NAD+ binding 5/2065 17/18639 0.294117647058824 2.65475003560746 0.0329113968353378 0.205288910953097 GO:0004722 protein serine/threonine phosphatase activity 18/2065 103/18639 0.174757281553398 1.57738545805026 0.0334786694945817 0.206573499070298 GO:0019905 syntaxin binding 12/2065 61/18639 0.19672131147541 1.77563608938991 0.0335716107881506 0.206573499070298 GO:1990841 promoter-specific chromatin binding 13/2065 68/18639 0.191176470588235 1.72558752314485 0.034235775560803 0.206573499070298 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 16/2065 89/18639 0.179775280898876 1.62267867344996 0.03435475577319 0.206573499070298 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 16/2065 89/18639 0.179775280898876 1.62267867344996 0.03435475577319 0.206573499070298 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 15/2065 82/18639 0.182926829268293 1.65112502214611 0.0345558700271592 0.206573499070298 GO:0033549 MAP kinase phosphatase activity 15/2065 82/18639 0.182926829268293 1.65112502214611 0.0345558700271592 0.206573499070298 GO:0004713 protein tyrosine kinase activity 23/2065 140/18639 0.164285714285714 1.48286751988931 0.0345910325317593 0.206573499070298 GO:0005158 insulin receptor binding 6/2065 23/18639 0.260869565217391 2.35464785766923 0.0353298591193163 0.206573499070298 GO:0010484 histone H3 acetyltransferase activity 7/2065 29/18639 0.241379310344828 2.17872589129164 0.035469376425923 0.206573499070298 GO:0051861 glycolipid binding 7/2065 29/18639 0.241379310344828 2.17872589129164 0.035469376425923 0.206573499070298 GO:0016208 AMP binding 4/2065 12/18639 0.333333333333333 3.00871670702179 0.0358525404306203 0.206573499070298 GO:0035259 nuclear glucocorticoid receptor binding 4/2065 12/18639 0.333333333333333 3.00871670702179 0.0358525404306203 0.206573499070298 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 4/2065 12/18639 0.333333333333333 3.00871670702179 0.0358525404306203 0.206573499070298 GO:0070008 serine-type exopeptidase activity 4/2065 12/18639 0.333333333333333 3.00871670702179 0.0358525404306203 0.206573499070298 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 4/2065 12/18639 0.333333333333333 3.00871670702179 0.0358525404306203 0.206573499070298 GO:0045296 cadherin binding 48/2065 334/18639 0.143712574850299 1.29717127488365 0.0359044415050755 0.206573499070298 GO:0051015 actin filament binding 32/2065 209/18639 0.15311004784689 1.38199427690953 0.0365442222165611 0.208882874936991 GO:0098632 cell-cell adhesion mediator activity 11/2065 55/18639 0.2 1.80523002421308 0.0366373931437103 0.208882874936991 GO:0015179 L-amino acid transmembrane transporter activity 12/2065 62/18639 0.193548387096774 1.74699679762556 0.0375853730462087 0.212703139000362 GO:0140793 histone H2AXY142 phosphatase activity 16/2065 90/18639 0.177777777777778 1.60464891041162 0.0376450793627625 0.212703139000362 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 15/2065 83/18639 0.180722891566265 1.63123194959013 0.0380188066333524 0.213855787312608 GO:0008234 cysteine-type peptidase activity 29/2065 187/18639 0.155080213903743 1.39977729150212 0.0388052705127412 0.216734001758518 GO:0004857 enzyme inhibitor activity 58/2065 416/18639 0.139423076923077 1.25845362264854 0.0388745114265279 0.216734001758518 GO:0000900 mRNA regulatory element binding translation repressor activity 5/2065 18/18639 0.277777777777778 2.50726392251816 0.0415320996343347 0.220013875035086 GO:0015172 acidic amino acid transmembrane transporter activity 5/2065 18/18639 0.277777777777778 2.50726392251816 0.0415320996343347 0.220013875035086 GO:0016854 racemase and epimerase activity 5/2065 18/18639 0.277777777777778 2.50726392251816 0.0415320996343347 0.220013875035086 GO:0030228 lipoprotein particle receptor activity 5/2065 18/18639 0.277777777777778 2.50726392251816 0.0415320996343347 0.220013875035086 GO:0034185 apolipoprotein binding 5/2065 18/18639 0.277777777777778 2.50726392251816 0.0415320996343347 0.220013875035086 GO:0035615 clathrin adaptor activity 5/2065 18/18639 0.277777777777778 2.50726392251816 0.0415320996343347 0.220013875035086 GO:0098641 cadherin binding involved in cell-cell adhesion 5/2065 18/18639 0.277777777777778 2.50726392251816 0.0415320996343347 0.220013875035086 GO:1990381 ubiquitin-specific protease binding 5/2065 18/18639 0.277777777777778 2.50726392251816 0.0415320996343347 0.220013875035086 GO:0004860 protein kinase inhibitor activity 15/2065 84/18639 0.178571428571429 1.61181252161882 0.0417241718455981 0.220013875035086 GO:0017018 myosin phosphatase activity 15/2065 84/18639 0.178571428571429 1.61181252161882 0.0417241718455981 0.220013875035086 GO:0032452 histone demethylase activity 7/2065 30/18639 0.233333333333333 2.10610169491525 0.0419915157239869 0.220013875035086 GO:0043995 histone H4K5 acetyltransferase activity 7/2065 30/18639 0.233333333333333 2.10610169491525 0.0419915157239869 0.220013875035086 GO:0043996 histone H4K8 acetyltransferase activity 7/2065 30/18639 0.233333333333333 2.10610169491525 0.0419915157239869 0.220013875035086 GO:0043997 histone H4K12 acetyltransferase activity 7/2065 30/18639 0.233333333333333 2.10610169491525 0.0419915157239869 0.220013875035086 GO:0008028 monocarboxylic acid transmembrane transporter activity 13/2065 70/18639 0.185714285714286 1.67628502248357 0.0421838922195792 0.220013875035086 GO:0035035 histone acetyltransferase binding 6/2065 24/18639 0.25 2.25653753026634 0.0428341126376839 0.220013875035086 GO:0050431 transforming growth factor beta binding 6/2065 24/18639 0.25 2.25653753026634 0.0428341126376839 0.220013875035086 GO:0050699 WW domain binding 6/2065 24/18639 0.25 2.25653753026634 0.0428341126376839 0.220013875035086 GO:0060229 lipase activator activity 6/2065 24/18639 0.25 2.25653753026634 0.0428341126376839 0.220013875035086 GO:0008013 beta-catenin binding 18/2065 106/18639 0.169811320754717 1.53274247338846 0.0429550898878025 0.220013875035086 GO:0048156 tau protein binding 9/2065 43/18639 0.209302325581395 1.88919421138578 0.0431424345526053 0.220078815936367 GO:0019855 calcium channel inhibitor activity 4/2065 13/18639 0.307692307692308 2.77727696032781 0.0473623137194174 0.23886394606397 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/2065 13/18639 0.307692307692308 2.77727696032781 0.0473623137194174 0.23886394606397 GO:0004721 phosphoprotein phosphatase activity 27/2065 175/18639 0.154285714285714 1.39260601867866 0.0473936400920576 0.23886394606397 GO:0001046 core promoter sequence-specific DNA binding 9/2065 44/18639 0.204545454545455 1.84625797930883 0.0491115740953222 0.246212860849722 GO:0140457 protein demethylase activity 7/2065 31/18639 0.225806451612903 2.03816293056315 0.0492425721699443 0.246212860849722 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 15/2065 86/18639 0.174418604651163 1.57432850948815 0.0498912670853476 0.248470342006079 GO:0061135 endopeptidase regulator activity 28/2065 184/18639 0.152173913043478 1.37354458364038 0.0511588306014036 0.250362458253315 GO:0004709 MAP kinase kinase kinase activity 6/2065 25/18639 0.24 2.16627602905569 0.0512646938328216 0.250362458253315 GO:0015645 fatty acid ligase activity 6/2065 25/18639 0.24 2.16627602905569 0.0512646938328216 0.250362458253315 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6/2065 25/18639 0.24 2.16627602905569 0.0512646938328216 0.250362458253315 GO:0120515 fatty acid-CoA ligase activity 6/2065 25/18639 0.24 2.16627602905569 0.0512646938328216 0.250362458253315 GO:0015291 secondary active transmembrane transporter activity 41/2065 287/18639 0.142857142857143 1.28945001729505 0.0532551612867375 0.259079163016561 GO:0015078 proton transmembrane transporter activity 28/2065 185/18639 0.151351351351351 1.36612001832341 0.0541616411776109 0.262475645706884 GO:0008009 chemokine activity 9/2065 45/18639 0.2 1.80523002421308 0.0556005322254461 0.268416362467671 GO:1990782 protein tyrosine kinase binding 19/2065 117/18639 0.162393162393162 1.46578506239523 0.0564464068117666 0.27145981901842 GO:0030159 signaling receptor complex adaptor activity 10/2065 52/18639 0.192307692307692 1.73579810020488 0.0568042747956513 0.272142153013387 GO:0045309 protein phosphorylated amino acid binding 11/2065 59/18639 0.186440677966102 1.68284154799524 0.0571951319865645 0.272157455869264 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/2065 32/18639 0.21875 1.97447033898305 0.057239464924885 0.272157455869264 GO:0001618 virus receptor activity 14/2065 81/18639 0.172839506172839 1.56007532956685 0.0605384162739444 0.280012472612841 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 6/2065 26/18639 0.230769230769231 2.08295772024586 0.0606372273885795 0.280012472612841 GO:0008198 ferrous iron binding 6/2065 26/18639 0.230769230769231 2.08295772024586 0.0606372273885795 0.280012472612841 GO:0043548 phosphatidylinositol 3-kinase binding 6/2065 26/18639 0.230769230769231 2.08295772024586 0.0606372273885795 0.280012472612841 GO:0050681 nuclear androgen receptor binding 6/2065 26/18639 0.230769230769231 2.08295772024586 0.0606372273885795 0.280012472612841 GO:0008191 metalloendopeptidase inhibitor activity 4/2065 14/18639 0.285714285714286 2.57890003459011 0.0606693690661156 0.280012472612841 GO:0016530 metallochaperone activity 4/2065 14/18639 0.285714285714286 2.57890003459011 0.0606693690661156 0.280012472612841 GO:0046030 inositol trisphosphate phosphatase activity 4/2065 14/18639 0.285714285714286 2.57890003459011 0.0606693690661156 0.280012472612841 GO:0016407 acetyltransferase activity 16/2065 96/18639 0.166666666666667 1.5043583535109 0.0622677707901062 0.28178939908308 GO:0001614 purinergic nucleotide receptor activity 5/2065 20/18639 0.25 2.25653753026634 0.0624945640485549 0.28178939908308 GO:0016502 nucleotide receptor activity 5/2065 20/18639 0.25 2.25653753026634 0.0624945640485549 0.28178939908308 GO:0052745 inositol phosphate phosphatase activity 5/2065 20/18639 0.25 2.25653753026634 0.0624945640485549 0.28178939908308 GO:0004180 carboxypeptidase activity 9/2065 46/18639 0.195652173913043 1.76598589325192 0.0626198664629068 0.28178939908308 GO:0030276 clathrin binding 9/2065 46/18639 0.195652173913043 1.76598589325192 0.0626198664629068 0.28178939908308 GO:0030291 protein serine/threonine kinase inhibitor activity 9/2065 46/18639 0.195652173913043 1.76598589325192 0.0626198664629068 0.28178939908308 GO:0034212 protein N-acetyltransferase activity 10/2065 53/18639 0.188679245283019 1.70304719265384 0.0633641251314864 0.283116303778982 GO:1901505 carbohydrate derivative transmembrane transporter activity 10/2065 53/18639 0.188679245283019 1.70304719265384 0.0633641251314864 0.283116303778982 GO:0051087 protein-folding chaperone binding 21/2065 134/18639 0.156716417910448 1.41454591449532 0.0641898973456477 0.285792475814545 GO:0140272 exogenous protein binding 14/2065 82/18639 0.170731707317073 1.5410500206697 0.0658877640306354 0.290739263988055 GO:0030296 protein tyrosine kinase activator activity 7/2065 33/18639 0.212121212121212 1.91463790446841 0.0659931980163363 0.290739263988055 GO:0140416 transcription regulator inhibitor activity 7/2065 33/18639 0.212121212121212 1.91463790446841 0.0659931980163363 0.290739263988055 GO:0004177 aminopeptidase activity 8/2065 40/18639 0.2 1.80523002421308 0.0688881368989375 0.299801584918926 GO:0032451 demethylase activity 8/2065 40/18639 0.2 1.80523002421308 0.0688881368989375 0.299801584918926 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/2065 40/18639 0.2 1.80523002421308 0.0688881368989375 0.299801584918926 GO:0015399 primary active transmembrane transporter activity 25/2065 166/18639 0.150602409638554 1.35935995799177 0.0690019520845148 0.299801584918926 GO:0019210 kinase inhibitor activity 15/2065 90/18639 0.166666666666667 1.5043583535109 0.0694247901303407 0.300602184069516 GO:0061733 protein-lysine-acetyltransferase activity 9/2065 47/18639 0.191489361702128 1.72841172531039 0.0701773535662943 0.302710062773568 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 10/2065 54/18639 0.185185185185185 1.67150928167877 0.0703921018989329 0.302710062773568 GO:0004683 calcium/calmodulin-dependent protein kinase activity 6/2065 27/18639 0.222222222222222 2.00581113801453 0.0709576535437052 0.303073367678198 GO:0016405 CoA-ligase activity 6/2065 27/18639 0.222222222222222 2.00581113801453 0.0709576535437052 0.303073367678198 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 20/2065 128/18639 0.15625 1.41033595641646 0.0712895820962488 0.303462410274572 GO:0030165 PDZ domain binding 14/2065 83/18639 0.168674698795181 1.52248315295079 0.0715423350967505 0.303512936774093 GO:0004725 protein tyrosine phosphatase activity 16/2065 98/18639 0.163265306122449 1.47365716262292 0.0724667751755796 0.305378383683044 GO:0042626 ATPase-coupled transmembrane transporter activity 16/2065 98/18639 0.163265306122449 1.47365716262292 0.0724667751755796 0.305378383683044 GO:0019838 growth factor binding 21/2065 136/18639 0.154411764705882 1.39374376869392 0.0728441678128462 0.305945504813954 GO:0098631 cell adhesion mediator activity 13/2065 76/18639 0.171052631578947 1.54394673123487 0.0735378354513803 0.306822131235443 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/2065 21/18639 0.238095238095238 2.14908336215842 0.0748398588257719 0.306822131235443 GO:0005123 death receptor binding 5/2065 21/18639 0.238095238095238 2.14908336215842 0.0748398588257719 0.306822131235443 GO:0051010 microtubule plus-end binding 5/2065 21/18639 0.238095238095238 2.14908336215842 0.0748398588257719 0.306822131235443 GO:0061891 calcium ion sensor activity 5/2065 21/18639 0.238095238095238 2.14908336215842 0.0748398588257719 0.306822131235443 GO:0072341 modified amino acid binding 15/2065 91/18639 0.164835164835165 1.48782694303275 0.0750038976147236 0.306822131235443 GO:0008080 N-acetyltransferase activity 12/2065 69/18639 0.173913043478261 1.56976523844615 0.0753381629206266 0.306822131235443 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 7/2065 34/18639 0.205882352941176 1.85832502492522 0.0755087935062658 0.306822131235443 GO:0004467 long-chain fatty acid-CoA ligase activity 4/2065 15/18639 0.266666666666667 2.40697336561743 0.0757314942970023 0.306822131235443 GO:0005041 low-density lipoprotein particle receptor activity 4/2065 15/18639 0.266666666666667 2.40697336561743 0.0757314942970023 0.306822131235443 GO:0120283 protein serine/threonine kinase binding 4/2065 15/18639 0.266666666666667 2.40697336561743 0.0757314942970023 0.306822131235443 GO:0016877 ligase activity, forming carbon-sulfur bonds 8/2065 41/18639 0.195121951219512 1.76120002362251 0.0776590375302035 0.312621045648743 GO:0061650 ubiquitin-like protein conjugating enzyme activity 8/2065 41/18639 0.195121951219512 1.76120002362251 0.0776590375302035 0.312621045648743 GO:0141052 histone H3 demethylase activity 6/2065 28/18639 0.214285714285714 1.93417502594258 0.0822224250057543 0.328396079657349 GO:0017124 SH3 domain binding 18/2065 115/18639 0.156521739130435 1.41278871460154 0.0826201139133556 0.328396079657349 GO:0005154 epidermal growth factor receptor binding 7/2065 35/18639 0.2 1.80523002421308 0.0857853224567082 0.328396079657349 GO:0010485 histone H4 acetyltransferase activity 7/2065 35/18639 0.2 1.80523002421308 0.0857853224567082 0.328396079657349 GO:0016229 steroid dehydrogenase activity 7/2065 35/18639 0.2 1.80523002421308 0.0857853224567082 0.328396079657349 GO:0061631 ubiquitin conjugating enzyme activity 7/2065 35/18639 0.2 1.80523002421308 0.0857853224567082 0.328396079657349 GO:0051213 dioxygenase activity 15/2065 93/18639 0.161290322580645 1.45583066468796 0.0870214679468915 0.328396079657349 GO:0004402 histone acetyltransferase activity 8/2065 42/18639 0.19047619047619 1.71926668972674 0.0870658968398902 0.328396079657349 GO:0032931 histone H3K56 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0043992 histone H3K9 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0043993 histone H3K18 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0043994 histone H3K23 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0043999 histone H2AK5 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0044012 histone H2AK9 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0044014 histone H2BK5 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0044015 histone H2BK12 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0044016 histone H3K4 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0044017 histone H3K27 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0044018 histone H3K36 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0046972 histone H4K16 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0061133 endopeptidase activator activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0140784 metal ion sensor activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0140908 histone H3K122 acetyltransferase activity 5/2065 22/18639 0.227272727272727 2.05139775478759 0.0884025755178548 0.328396079657349 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:0005345 purine nucleobase transmembrane transporter activity 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:0043422 protein kinase B binding 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:0070513 death domain binding 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:0071723 lipopeptide binding 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:1905394 retromer complex binding 3/2065 10/18639 0.3 2.70784503631961 0.0899179741918931 0.328396079657349 GO:0005024 transforming growth factor beta receptor activity 4/2065 16/18639 0.25 2.25653753026634 0.0924756134577075 0.332912208447747 GO:0005521 lamin binding 4/2065 16/18639 0.25 2.25653753026634 0.0924756134577075 0.332912208447747 GO:0015923 mannosidase activity 4/2065 16/18639 0.25 2.25653753026634 0.0924756134577075 0.332912208447747 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/2065 16/18639 0.25 2.25653753026634 0.0924756134577075 0.332912208447747 GO:0070411 I-SMAD binding 4/2065 16/18639 0.25 2.25653753026634 0.0924756134577075 0.332912208447747 GO:0008017 microtubule binding 38/2065 276/18639 0.13768115942029 1.24273081376987 0.0932415813278617 0.334713368869247 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 6/2065 29/18639 0.206896551724138 1.86747933539284 0.0944188724613625 0.337976645742377 GO:0005518 collagen binding 12/2065 72/18639 0.166666666666667 1.5043583535109 0.0970548848700173 0.345449590215316 GO:0042379 chemokine receptor binding 12/2065 72/18639 0.166666666666667 1.5043583535109 0.0970548848700173 0.345449590215316 GO:0022853 active monoatomic ion transmembrane transporter activity 18/2065 118/18639 0.152542372881356 1.37687035745065 0.0999145596452052 0.354626324374531 GO:0001217 DNA-binding transcription repressor activity 38/2065 278/18639 0.136690647482014 1.23379030431829 0.100910904335739 0.356572047575116 GO:0015631 tubulin binding 51/2065 385/18639 0.132467532467532 1.19567183421905 0.10102874681295 0.356572047575116 GO:0043274 phospholipase binding 5/2065 23/18639 0.217391304347826 1.96220654805769 0.103144996739671 0.362013080479068 GO:0044013 histone H2B acetyltransferase activity 5/2065 23/18639 0.217391304347826 1.96220654805769 0.103144996739671 0.362013080479068 GO:1902936 phosphatidylinositol bisphosphate binding 17/2065 111/18639 0.153153153153153 1.38238335187488 0.104558608889321 0.365955131112625 GO:0001223 transcription coactivator binding 8/2065 44/18639 0.181818181818182 1.64111820383007 0.107770872311004 0.37615318313536 GO:0008235 metalloexopeptidase activity 11/2065 66/18639 0.166666666666667 1.5043583535109 0.108916971393461 0.379103270596024 GO:0005516 calmodulin binding 29/2065 207/18639 0.140096618357488 1.26453310874829 0.109864584653885 0.380413791702786 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/2065 17/18639 0.235294117647059 2.12380002848597 0.110803064726129 0.380413791702786 GO:0008484 sulfuric ester hydrolase activity 4/2065 17/18639 0.235294117647059 2.12380002848597 0.110803064726129 0.380413791702786 GO:0016805 dipeptidase activity 4/2065 17/18639 0.235294117647059 2.12380002848597 0.110803064726129 0.380413791702786 GO:0019198 transmembrane receptor protein phosphatase activity 4/2065 17/18639 0.235294117647059 2.12380002848597 0.110803064726129 0.380413791702786 GO:0001664 G protein-coupled receptor binding 40/2065 297/18639 0.134680134680135 1.2156431139482 0.111399543181147 0.381422348935448 GO:0031490 chromatin DNA binding 19/2065 128/18639 0.1484375 1.33981915859564 0.113720606646896 0.381459540554323 GO:0001851 complement component C3b binding 3/2065 11/18639 0.272727272727273 2.4616773057451 0.113832370832084 0.381459540554323 GO:0005114 type II transforming growth factor beta receptor binding 3/2065 11/18639 0.272727272727273 2.4616773057451 0.113832370832084 0.381459540554323 GO:0008199 ferric iron binding 3/2065 11/18639 0.272727272727273 2.4616773057451 0.113832370832084 0.381459540554323 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 3/2065 11/18639 0.272727272727273 2.4616773057451 0.113832370832084 0.381459540554323 GO:0015205 nucleobase transmembrane transporter activity 3/2065 11/18639 0.272727272727273 2.4616773057451 0.113832370832084 0.381459540554323 GO:0019215 intermediate filament binding 3/2065 11/18639 0.272727272727273 2.4616773057451 0.113832370832084 0.381459540554323 GO:0070697 activin receptor binding 3/2065 11/18639 0.272727272727273 2.4616773057451 0.113832370832084 0.381459540554323 GO:0005080 protein kinase C binding 9/2065 52/18639 0.173076923076923 1.56221829018439 0.116107746679 0.38805241595634 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 5/2065 24/18639 0.208333333333333 1.88044794188862 0.119016282029668 0.395674183001006 GO:0043998 histone H2A acetyltransferase activity 5/2065 24/18639 0.208333333333333 1.88044794188862 0.119016282029668 0.395674183001006 GO:0005164 tumor necrosis factor receptor binding 6/2065 31/18639 0.193548387096774 1.74699679762556 0.121513665119889 0.399309741662566 GO:0016878 acid-thiol ligase activity 6/2065 31/18639 0.193548387096774 1.74699679762556 0.121513665119889 0.399309741662566 GO:0047499 calcium-independent phospholipase A2 activity 6/2065 31/18639 0.193548387096774 1.74699679762556 0.121513665119889 0.399309741662566 GO:0030414 peptidase inhibitor activity 24/2065 169/18639 0.142011834319527 1.28182013553591 0.121647873861112 0.399309741662566 GO:0004866 endopeptidase inhibitor activity 23/2065 161/18639 0.142857142857143 1.28945001729505 0.121694397459068 0.399309741662566 GO:0019003 GDP binding 12/2065 75/18639 0.16 1.44418401937046 0.122179161739827 0.399859074784889 GO:0005544 calcium-dependent phospholipid binding 9/2065 53/18639 0.169811320754717 1.53274247338846 0.12689621472281 0.411291764062031 GO:0140296 general transcription initiation factor binding 9/2065 53/18639 0.169811320754717 1.53274247338846 0.12689621472281 0.411291764062031 GO:0016298 lipase activity 19/2065 130/18639 0.146153846153846 1.31920655615571 0.126978171603278 0.411291764062031 GO:0016798 hydrolase activity, acting on glycosyl bonds 19/2065 130/18639 0.146153846153846 1.31920655615571 0.126978171603278 0.411291764062031 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/2065 18/18639 0.222222222222222 2.00581113801453 0.13059476903807 0.417638093878092 GO:0004706 JUN kinase kinase kinase activity 4/2065 18/18639 0.222222222222222 2.00581113801453 0.13059476903807 0.417638093878092 GO:0008409 5'-3' exonuclease activity 4/2065 18/18639 0.222222222222222 2.00581113801453 0.13059476903807 0.417638093878092 GO:0017075 syntaxin-1 binding 4/2065 18/18639 0.222222222222222 2.00581113801453 0.13059476903807 0.417638093878092 GO:0050811 GABA receptor binding 4/2065 18/18639 0.222222222222222 2.00581113801453 0.13059476903807 0.417638093878092 GO:0140034 methylation-dependent protein binding 12/2065 76/18639 0.157894736842105 1.42518159806295 0.131299410418911 0.418828499057792 GO:0031406 carboxylic acid binding 26/2065 187/18639 0.13903743315508 1.25497274410535 0.132553940913639 0.42176253927067 GO:0001848 complement binding 5/2065 25/18639 0.2 1.80523002421308 0.135954179078879 0.427187694861317 GO:0003707 nuclear steroid receptor activity 5/2065 25/18639 0.2 1.80523002421308 0.135954179078879 0.427187694861317 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 5/2065 25/18639 0.2 1.80523002421308 0.135954179078879 0.427187694861317 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 5/2065 25/18639 0.2 1.80523002421308 0.135954179078879 0.427187694861317 GO:0042974 nuclear retinoic acid receptor binding 5/2065 25/18639 0.2 1.80523002421308 0.135954179078879 0.427187694861317 GO:0002039 p53 binding 11/2065 69/18639 0.159420289855072 1.43895146857564 0.137354226472162 0.428662569384526 GO:0015485 cholesterol binding 9/2065 54/18639 0.166666666666667 1.5043583535109 0.138197037287585 0.428662569384526 GO:0046943 carboxylic acid transmembrane transporter activity 26/2065 188/18639 0.138297872340426 1.24829735716862 0.138459463317982 0.428662569384526 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 31/2065 229/18639 0.135371179039301 1.22188058407435 0.139342455102767 0.428662569384526 GO:0004000 adenosine deaminase activity 3/2065 12/18639 0.25 2.25653753026634 0.139825647632571 0.428662569384526 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2065 12/18639 0.25 2.25653753026634 0.139825647632571 0.428662569384526 GO:0016840 carbon-nitrogen lyase activity 3/2065 12/18639 0.25 2.25653753026634 0.139825647632571 0.428662569384526 GO:0035197 siRNA binding 3/2065 12/18639 0.25 2.25653753026634 0.139825647632571 0.428662569384526 GO:0035497 cAMP response element binding 3/2065 12/18639 0.25 2.25653753026634 0.139825647632571 0.428662569384526 GO:0070410 co-SMAD binding 3/2065 12/18639 0.25 2.25653753026634 0.139825647632571 0.428662569384526 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 19/2065 132/18639 0.143939393939394 1.29921857803214 0.141108827454739 0.431546414060608 GO:0005342 organic acid transmembrane transporter activity 26/2065 189/18639 0.137566137566138 1.24169260924709 0.144518033816468 0.439837494224034 GO:0043177 organic acid binding 26/2065 189/18639 0.137566137566138 1.24169260924709 0.144518033816468 0.439837494224034 GO:0071949 FAD binding 7/2065 40/18639 0.175 1.57957627118644 0.148154405529122 0.449818195100467 GO:0043395 heparan sulfate proteoglycan binding 4/2065 19/18639 0.210526315789474 1.90024213075061 0.151716123857194 0.456229061521124 GO:0097001 ceramide binding 4/2065 19/18639 0.210526315789474 1.90024213075061 0.151716123857194 0.456229061521124 GO:0140036 ubiquitin-modified protein reader activity 4/2065 19/18639 0.210526315789474 1.90024213075061 0.151716123857194 0.456229061521124 GO:0019956 chemokine binding 6/2065 33/18639 0.181818181818182 1.64111820383007 0.151980167266278 0.456229061521124 GO:0001637 G protein-coupled chemoattractant receptor activity 5/2065 26/18639 0.192307692307692 1.73579810020488 0.153886786624189 0.456229061521124 GO:0004529 DNA exonuclease activity 5/2065 26/18639 0.192307692307692 1.73579810020488 0.153886786624189 0.456229061521124 GO:0004950 chemokine receptor activity 5/2065 26/18639 0.192307692307692 1.73579810020488 0.153886786624189 0.456229061521124 GO:0005160 transforming growth factor beta receptor binding 5/2065 26/18639 0.192307692307692 1.73579810020488 0.153886786624189 0.456229061521124 GO:0052742 phosphatidylinositol kinase activity 5/2065 26/18639 0.192307692307692 1.73579810020488 0.153886786624189 0.456229061521124 GO:0070006 metalloaminopeptidase activity 5/2065 26/18639 0.192307692307692 1.73579810020488 0.153886786624189 0.456229061521124 GO:0016410 N-acyltransferase activity 14/2065 94/18639 0.148936170212766 1.34432023079697 0.154345185511842 0.456513928978687 GO:0033293 monocarboxylic acid binding 12/2065 79/18639 0.151898734177215 1.37106077788335 0.160814637294261 0.474534995294542 GO:0015175 neutral L-amino acid transmembrane transporter activity 7/2065 41/18639 0.170731707317073 1.5410500206697 0.162668157764194 0.478882894352533 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/2065 13/18639 0.230769230769231 2.08295772024586 0.167564647806518 0.48873022276901 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/2065 13/18639 0.230769230769231 2.08295772024586 0.167564647806518 0.48873022276901 GO:0070123 transforming growth factor beta receptor activity, type III 3/2065 13/18639 0.230769230769231 2.08295772024586 0.167564647806518 0.48873022276901 GO:0071714 icosanoid transmembrane transporter activity 3/2065 13/18639 0.230769230769231 2.08295772024586 0.167564647806518 0.48873022276901 GO:0060590 ATPase regulator activity 8/2065 49/18639 0.163265306122449 1.47365716262292 0.169976230355753 0.494619053691105 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 35/2065 268/18639 0.130597014925373 1.17878826207943 0.172060183519577 0.496906938940385 GO:0016651 oxidoreductase activity, acting on NAD(P)H 13/2065 88/18639 0.147727272727273 1.33340854061193 0.17262194421351 0.496906938940385 GO:0001671 ATPase activator activity 5/2065 27/18639 0.185185185185185 1.67150928167877 0.172734316869753 0.496906938940385 GO:0035255 ionotropic glutamate receptor binding 5/2065 27/18639 0.185185185185185 1.67150928167877 0.172734316869753 0.496906938940385 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 5/2065 27/18639 0.185185185185185 1.67150928167877 0.172734316869753 0.496906938940385 GO:0015095 magnesium ion transmembrane transporter activity 4/2065 20/18639 0.2 1.80523002421308 0.174021513809353 0.497204325169581 GO:0016505 peptidase activator activity involved in apoptotic process 4/2065 20/18639 0.2 1.80523002421308 0.174021513809353 0.497204325169581 GO:0042288 MHC class I protein binding 4/2065 20/18639 0.2 1.80523002421308 0.174021513809353 0.497204325169581 GO:0005178 integrin binding 22/2065 161/18639 0.136645962732919 1.23338697306483 0.17631248705358 0.502610257211564 GO:0003774 cytoskeletal motor activity 21/2065 153/18639 0.137254901960784 1.23888334995015 0.177680067155024 0.505365428025576 GO:0030971 receptor tyrosine kinase binding 12/2065 81/18639 0.148148148148148 1.33720742534302 0.182199923452086 0.516121884821019 GO:0141108 transporter regulator activity 23/2065 170/18639 0.135294117647059 1.22118501637943 0.182281141861392 0.516121884821019 GO:0004623 phospholipase A2 activity 6/2065 35/18639 0.171428571428571 1.54734002075406 0.185452731819986 0.523924758056462 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 9/2065 58/18639 0.155172413793103 1.40060950154463 0.188197115527218 0.530488513566656 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 17/2065 122/18639 0.139344262295082 1.25774222998452 0.19108444267635 0.537424995027235 GO:0019789 SUMO transferase activity 5/2065 28/18639 0.178571428571429 1.61181252161882 0.192410815101057 0.537855763695993 GO:0035064 methylated histone binding 11/2065 74/18639 0.148648648648649 1.3417250179962 0.192518213830867 0.537855763695993 GO:0048029 monosaccharide binding 11/2065 74/18639 0.148648648648649 1.3417250179962 0.192518213830867 0.537855763695993 GO:0030983 mismatched DNA binding 3/2065 14/18639 0.214285714285714 1.93417502594258 0.196717905644809 0.544139061258024 GO:0032454 histone H3K9 demethylase activity 3/2065 14/18639 0.214285714285714 1.93417502594258 0.196717905644809 0.544139061258024 GO:0061665 SUMO ligase activity 3/2065 14/18639 0.214285714285714 1.93417502594258 0.196717905644809 0.544139061258024 GO:0071933 Arp2/3 complex binding 3/2065 14/18639 0.214285714285714 1.93417502594258 0.196717905644809 0.544139061258024 GO:0035613 RNA stem-loop binding 4/2065 21/18639 0.19047619047619 1.71926668972674 0.19735837380549 0.544139061258024 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/2065 21/18639 0.19047619047619 1.71926668972674 0.19735837380549 0.544139061258024 GO:0035401 histone H3Y41 kinase activity 16/2065 115/18639 0.139130434782609 1.25581219075692 0.201722403499545 0.55154501780985 GO:0101005 deubiquitinase activity 16/2065 115/18639 0.139130434782609 1.25581219075692 0.201722403499545 0.55154501780985 GO:0140801 histone H2AXY142 kinase activity 16/2065 115/18639 0.139130434782609 1.25581219075692 0.201722403499545 0.55154501780985 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/2065 59/18639 0.152542372881356 1.37687035745065 0.201795439055826 0.55154501780985 GO:0016409 palmitoyltransferase activity 6/2065 36/18639 0.166666666666667 1.5043583535109 0.203180073122022 0.55412747215097 GO:0016790 thiolester hydrolase activity 7/2065 44/18639 0.159090909090909 1.43597842835131 0.20969165332547 0.569881064023293 GO:0009055 electron transfer activity 16/2065 116/18639 0.137931034482759 1.24498622359522 0.211551997336941 0.569881064023293 GO:0003785 actin monomer binding 5/2065 29/18639 0.172413793103448 1.55623277949403 0.212825803150994 0.569881064023293 GO:0004629 phospholipase C activity 5/2065 29/18639 0.172413793103448 1.55623277949403 0.212825803150994 0.569881064023293 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 5/2065 29/18639 0.172413793103448 1.55623277949403 0.212825803150994 0.569881064023293 GO:0097472 cyclin-dependent protein kinase activity 5/2065 29/18639 0.172413793103448 1.55623277949403 0.212825803150994 0.569881064023293 GO:0106222 lncRNA binding 5/2065 29/18639 0.172413793103448 1.55623277949403 0.212825803150994 0.569881064023293 GO:0004843 cysteine-type deubiquitinase activity 15/2065 108/18639 0.138888888888889 1.25363196125908 0.213171788159563 0.569881064023293 GO:0005496 steroid binding 15/2065 108/18639 0.138888888888889 1.25363196125908 0.213171788159563 0.569881064023293 GO:0003823 antigen binding 23/2065 174/18639 0.132183908045977 1.19311179761209 0.213479255729361 0.569881064023293 GO:0043178 alcohol binding 13/2065 92/18639 0.141304347826087 1.2754342562375 0.215773544253247 0.573608487517766 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 9/2065 60/18639 0.15 1.35392251815981 0.215786050066207 0.573608487517766 GO:0051117 ATPase binding 12/2065 84/18639 0.142857142857143 1.28945001729505 0.216615372481013 0.573916271294056 GO:0032934 sterol binding 10/2065 68/18639 0.147058823529412 1.32737501780373 0.216812813599977 0.573916271294056 GO:0008970 phospholipase A1 activity 4/2065 22/18639 0.181818181818182 1.64111820383007 0.221570773424964 0.581623280240532 GO:0031683 G-protein beta/gamma-subunit complex binding 4/2065 22/18639 0.181818181818182 1.64111820383007 0.221570773424964 0.581623280240532 GO:0050321 tau-protein kinase activity 4/2065 22/18639 0.181818181818182 1.64111820383007 0.221570773424964 0.581623280240532 GO:0140035 ubiquitin-like protein reader activity 4/2065 22/18639 0.181818181818182 1.64111820383007 0.221570773424964 0.581623280240532 GO:0004620 phospholipase activity 15/2065 109/18639 0.137614678899083 1.24213075060533 0.223636982053686 0.585826605795519 GO:0004559 alpha-mannosidase activity 3/2065 15/18639 0.2 1.80523002421308 0.226964508481761 0.590327162310776 GO:0015929 hexosaminidase activity 3/2065 15/18639 0.2 1.80523002421308 0.226964508481761 0.590327162310776 GO:0017081 chloride channel regulator activity 3/2065 15/18639 0.2 1.80523002421308 0.226964508481761 0.590327162310776 GO:0051219 phosphoprotein binding 13/2065 93/18639 0.139784946236559 1.26171990939624 0.227229106127561 0.590327162310776 GO:0015026 coreceptor activity 9/2065 61/18639 0.147540983606557 1.33172706704243 0.230142635399804 0.596666091777269 GO:0001965 G-protein alpha-subunit binding 5/2065 30/18639 0.166666666666667 1.5043583535109 0.233885821452051 0.603885522601606 GO:0035925 mRNA 3'-UTR AU-rich region binding 5/2065 30/18639 0.166666666666667 1.5043583535109 0.233885821452051 0.603885522601606 GO:0015297 antiporter activity 18/2065 135/18639 0.133333333333333 1.20348668280872 0.236343229761638 0.608640922436848 GO:0015171 amino acid transmembrane transporter activity 14/2065 102/18639 0.137254901960784 1.23888334995015 0.236693692058774 0.608640922436848 GO:0019783 ubiquitin-like protein peptidase activity 17/2065 127/18639 0.133858267716535 1.20822481935521 0.239314485002178 0.614126784323307 GO:0050660 flavin adenine dinucleotide binding 12/2065 86/18639 0.13953488372093 1.25946280759052 0.240956860848367 0.617084643636063 GO:0051287 NAD binding 8/2065 54/18639 0.148148148148148 1.33720742534302 0.244797299312816 0.625648270048982 GO:0004602 glutathione peroxidase activity 4/2065 23/18639 0.173913043478261 1.56976523844615 0.246502515885026 0.627460949525521 GO:0005283 amino acid:sodium symporter activity 4/2065 23/18639 0.173913043478261 1.56976523844615 0.246502515885026 0.627460949525521 GO:0000062 fatty-acyl-CoA binding 3/2065 16/18639 0.1875 1.69240314769976 0.258000407333465 0.649141235116008 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/2065 16/18639 0.1875 1.69240314769976 0.258000407333465 0.649141235116008 GO:0016722 oxidoreductase activity, acting on metal ions 3/2065 16/18639 0.1875 1.69240314769976 0.258000407333465 0.649141235116008 GO:0034450 ubiquitin-ubiquitin ligase activity 3/2065 16/18639 0.1875 1.69240314769976 0.258000407333465 0.649141235116008 GO:0055102 lipase inhibitor activity 3/2065 16/18639 0.1875 1.69240314769976 0.258000407333465 0.649141235116008 GO:0140299 molecular sensor activity 10/2065 71/18639 0.140845070422535 1.27128874944583 0.258110919677079 0.649141235116008 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 6/2065 39/18639 0.153846153846154 1.3886384801639 0.259592038432026 0.651565674152098 GO:0015293 symporter activity 19/2065 146/18639 0.13013698630137 1.17463597465919 0.26226733605651 0.656971855728037 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 17/2065 130/18639 0.130769230769231 1.18034270813932 0.270428002556431 0.66937441591149 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/2065 24/18639 0.166666666666667 1.5043583535109 0.271999762656098 0.66937441591149 GO:0004622 lysophospholipase activity 4/2065 24/18639 0.166666666666667 1.5043583535109 0.271999762656098 0.66937441591149 GO:0004806 triacylglycerol lipase activity 4/2065 24/18639 0.166666666666667 1.5043583535109 0.271999762656098 0.66937441591149 GO:0015295 solute:proton symporter activity 4/2065 24/18639 0.166666666666667 1.5043583535109 0.271999762656098 0.66937441591149 GO:0019957 C-C chemokine binding 4/2065 24/18639 0.166666666666667 1.5043583535109 0.271999762656098 0.66937441591149 GO:0030215 semaphorin receptor binding 4/2065 24/18639 0.166666666666667 1.5043583535109 0.271999762656098 0.66937441591149 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/2065 24/18639 0.166666666666667 1.5043583535109 0.271999762656098 0.66937441591149 GO:0140033 acetylation-dependent protein binding 4/2065 24/18639 0.166666666666667 1.5043583535109 0.271999762656098 0.66937441591149 GO:0004536 DNA nuclease activity 9/2065 64/18639 0.140625 1.26930236077482 0.275127232724165 0.675751097919003 GO:0043425 bHLH transcription factor binding 5/2065 32/18639 0.15625 1.41033595641646 0.2775606068231 0.679080319606032 GO:0047498 calcium-dependent phospholipase A2 activity 5/2065 32/18639 0.15625 1.41033595641646 0.2775606068231 0.679080319606032 GO:0015036 disulfide oxidoreductase activity 6/2065 40/18639 0.15 1.35392251815981 0.279257503061951 0.681907856314066 GO:0043539 protein serine/threonine kinase activator activity 10/2065 73/18639 0.136986301369863 1.23645892069389 0.286976618005075 0.684531929365023 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:0005092 GDP-dissociation inhibitor activity 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:0045236 CXCR chemokine receptor binding 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:0046965 nuclear retinoid X receptor binding 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:0048038 quinone binding 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:1901567 fatty acid derivative binding 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:1990226 histone methyltransferase binding 3/2065 17/18639 0.176470588235294 1.59285002136448 0.289542695035038 0.684531929365023 GO:0160215 deacylase activity 9/2065 65/18639 0.138461538461538 1.24977463214751 0.290662189149565 0.684531929365023 GO:0008514 organic anion transmembrane transporter activity 33/2065 269/18639 0.122676579925651 1.1072972267478 0.292695012471823 0.684531929365023 GO:0004601 peroxidase activity 8/2065 57/18639 0.140350877192982 1.26682808716707 0.29408887683221 0.684531929365023 GO:0035254 glutamate receptor binding 7/2065 49/18639 0.142857142857143 1.28945001729505 0.297063067036111 0.684531929365023 GO:0008139 nuclear localization sequence binding 4/2065 25/18639 0.16 1.44418401937046 0.297913207146997 0.684531929365023 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/2065 25/18639 0.16 1.44418401937046 0.297913207146997 0.684531929365023 GO:0019707 protein-cysteine S-acyltransferase activity 4/2065 25/18639 0.16 1.44418401937046 0.297913207146997 0.684531929365023 GO:0047617 fatty acyl-CoA hydrolase activity 4/2065 25/18639 0.16 1.44418401937046 0.297913207146997 0.684531929365023 GO:0120020 cholesterol transfer activity 4/2065 25/18639 0.16 1.44418401937046 0.297913207146997 0.684531929365023 GO:0008137 NADH dehydrogenase (ubiquinone) activity 6/2065 41/18639 0.146341463414634 1.32090001771688 0.299244247970138 0.684531929365023 GO:0042287 MHC protein binding 6/2065 41/18639 0.146341463414634 1.32090001771688 0.299244247970138 0.684531929365023 GO:0140318 protein transporter activity 6/2065 41/18639 0.146341463414634 1.32090001771688 0.299244247970138 0.684531929365023 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/2065 33/18639 0.151515151515152 1.36759850319172 0.29998568531539 0.684531929365023 GO:0071889 14-3-3 protein binding 5/2065 33/18639 0.151515151515152 1.36759850319172 0.29998568531539 0.684531929365023 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 12/2065 91/18639 0.131868131868132 1.1902615544262 0.305765414510092 0.684531929365023 GO:0001094 TFIID-class transcription factor complex binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0004382 GDP phosphatase activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0004955 prostaglandin receptor activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0015187 glycine transmembrane transporter activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0030957 Tat protein binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0031419 cobalamin binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0035256 G protein-coupled glutamate receptor binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0043121 neurotrophin binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0050308 sugar-phosphatase activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0051864 histone H3K36 demethylase activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0051880 G-quadruplex DNA binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0070097 delta-catenin binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0140999 histone H3K4 trimethyltransferase activity 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:1990763 arrestin family protein binding 2/2065 10/18639 0.2 1.80523002421308 0.305866250978181 0.684531929365023 GO:0061980 regulatory RNA binding 8/2065 58/18639 0.137931034482759 1.24498622359522 0.311031558641008 0.694857737389486 GO:0016247 channel regulator activity 21/2065 168/18639 0.125 1.12826876513317 0.311898631290618 0.695561549426865 GO:0015605 organophosphate ester transmembrane transporter activity 7/2065 50/18639 0.14 1.26366101694915 0.315461302006146 0.701025115569214 GO:0048020 CCR chemokine receptor binding 7/2065 50/18639 0.14 1.26366101694915 0.315461302006146 0.701025115569214 GO:0099106 ion channel regulator activity 20/2065 160/18639 0.125 1.12826876513317 0.317661225665681 0.704078938992924 GO:0052689 carboxylic ester hydrolase activity 12/2065 92/18639 0.130434782608696 1.17732392883461 0.319264195048618 0.704078938992924 GO:0042056 chemoattractant activity 6/2065 42/18639 0.142857142857143 1.28945001729505 0.319486854306985 0.704078938992924 GO:0048487 beta-tubulin binding 6/2065 42/18639 0.142857142857143 1.28945001729505 0.319486854306985 0.704078938992924 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/2065 18/18639 0.166666666666667 1.5043583535109 0.321332280234431 0.704078938992924 GO:0070064 proline-rich region binding 3/2065 18/18639 0.166666666666667 1.5043583535109 0.321332280234431 0.704078938992924 GO:0016831 carboxy-lyase activity 5/2065 34/18639 0.147058823529412 1.32737501780373 0.322678581022379 0.704078938992924 GO:0004435 phosphatidylinositol phospholipase C activity 4/2065 26/18639 0.153846153846154 1.3886384801639 0.324099829060235 0.704078938992924 GO:0005227 calcium-activated cation channel activity 4/2065 26/18639 0.153846153846154 1.3886384801639 0.324099829060235 0.704078938992924 GO:0008157 protein phosphatase 1 binding 4/2065 26/18639 0.153846153846154 1.3886384801639 0.324099829060235 0.704078938992924 GO:0016289 acyl-CoA hydrolase activity 4/2065 26/18639 0.153846153846154 1.3886384801639 0.324099829060235 0.704078938992924 GO:0034237 protein kinase A regulatory subunit binding 4/2065 26/18639 0.153846153846154 1.3886384801639 0.324099829060235 0.704078938992924 GO:0097602 cullin family protein binding 4/2065 26/18639 0.153846153846154 1.3886384801639 0.324099829060235 0.704078938992924 GO:0000287 magnesium ion binding 28/2065 230/18639 0.121739130434783 1.09883566691231 0.326934289385913 0.709014121559812 GO:0017022 myosin binding 10/2065 76/18639 0.131578947368421 1.18765133171913 0.331779233475749 0.718284938452651 GO:0016830 carbon-carbon lyase activity 7/2065 51/18639 0.137254901960784 1.23888334995015 0.334053750514897 0.721968654629109 GO:0044325 transmembrane transporter binding 17/2065 136/18639 0.125 1.12826876513317 0.336417104253991 0.723496731771555 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 9/2065 68/18639 0.132352941176471 1.19463751602336 0.338459702536093 0.723496731771555 GO:0004712 protein serine/threonine/tyrosine kinase activity 6/2065 43/18639 0.13953488372093 1.25946280759052 0.339920887391584 0.723496731771555 GO:0008375 acetylglucosaminyltransferase activity 6/2065 43/18639 0.13953488372093 1.25946280759052 0.339920887391584 0.723496731771555 GO:0005343 organic acid:sodium symporter activity 5/2065 35/18639 0.142857142857143 1.28945001729505 0.345549555889445 0.723496731771555 GO:0140566 histone reader activity 5/2065 35/18639 0.142857142857143 1.28945001729505 0.345549555889445 0.723496731771555 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0004954 prostanoid receptor activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0005225 volume-sensitive anion channel activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0010854 adenylate cyclase regulator activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0019107 myristoyltransferase activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0019203 carbohydrate phosphatase activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0019206 nucleoside kinase activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0032404 mismatch repair complex binding 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0034713 type I transforming growth factor beta receptor binding 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0043522 leucine zipper domain binding 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0048185 activin binding 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0097493 structural molecule activity conferring elasticity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0180030 inositol phosphate kinase activity 2/2065 11/18639 0.181818181818182 1.64111820383007 0.348540446566203 0.723496731771555 GO:0004364 glutathione transferase activity 4/2065 27/18639 0.148148148148148 1.33720742534302 0.350424265962927 0.723496731771555 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2065 19/18639 0.157894736842105 1.42518159806295 0.353135309555164 0.723496731771555 GO:0008574 plus-end-directed microtubule motor activity 3/2065 19/18639 0.157894736842105 1.42518159806295 0.353135309555164 0.723496731771555 GO:0030506 ankyrin binding 3/2065 19/18639 0.157894736842105 1.42518159806295 0.353135309555164 0.723496731771555 GO:0042800 histone H3K4 methyltransferase activity 3/2065 19/18639 0.157894736842105 1.42518159806295 0.353135309555164 0.723496731771555 GO:0042834 peptidoglycan binding 3/2065 19/18639 0.157894736842105 1.42518159806295 0.353135309555164 0.723496731771555 GO:0046624 sphingolipid transporter activity 3/2065 19/18639 0.157894736842105 1.42518159806295 0.353135309555164 0.723496731771555 GO:0070003 threonine-type peptidase activity 3/2065 19/18639 0.157894736842105 1.42518159806295 0.353135309555164 0.723496731771555 GO:0120227 acyl-CoA binding 3/2065 19/18639 0.157894736842105 1.42518159806295 0.353135309555164 0.723496731771555 GO:0003954 NADH dehydrogenase activity 6/2065 44/18639 0.136363636363636 1.23083865287255 0.360483398033602 0.736157344444634 GO:0019205 nucleobase-containing compound kinase activity 6/2065 44/18639 0.136363636363636 1.23083865287255 0.360483398033602 0.736157344444634 GO:0016836 hydro-lyase activity 8/2065 61/18639 0.131147540983607 1.18375739292661 0.362861741588368 0.739536723040286 GO:0004033 aldo-keto reductase (NADPH) activity 5/2065 36/18639 0.138888888888889 1.25363196125908 0.368512375690642 0.739536723040286 GO:0004190 aspartic-type endopeptidase activity 5/2065 36/18639 0.138888888888889 1.25363196125908 0.368512375690642 0.739536723040286 GO:0008081 phosphoric diester hydrolase activity 11/2065 87/18639 0.126436781609195 1.14123737162896 0.368843935072878 0.739536723040286 GO:0097110 scaffold protein binding 9/2065 70/18639 0.128571428571429 1.16050501556555 0.371009422094659 0.739536723040286 GO:0051018 protein kinase A binding 7/2065 53/18639 0.132075471698113 1.19213303485769 0.371629472278515 0.739536723040286 GO:0046625 sphingolipid binding 4/2065 28/18639 0.142857142857143 1.28945001729505 0.376759841106572 0.739536723040286 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2065 28/18639 0.142857142857143 1.28945001729505 0.376759841106572 0.739536723040286 GO:0140303 intramembrane lipid transporter activity 6/2065 45/18639 0.133333333333333 1.20348668280872 0.381113362999318 0.739536723040286 GO:0016408 C-acyltransferase activity 3/2065 20/18639 0.15 1.35392251815981 0.384743626451483 0.739536723040286 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/2065 20/18639 0.15 1.35392251815981 0.384743626451483 0.739536723040286 GO:0031418 L-ascorbic acid binding 3/2065 20/18639 0.15 1.35392251815981 0.384743626451483 0.739536723040286 GO:0043024 ribosomal small subunit binding 3/2065 20/18639 0.15 1.35392251815981 0.384743626451483 0.739536723040286 GO:0008237 metallopeptidase activity 22/2065 184/18639 0.119565217391304 1.07921360143173 0.385543443293723 0.739536723040286 GO:0004175 endopeptidase activity 47/2065 405/18639 0.116049382716049 1.04747914985203 0.389972267375878 0.739536723040286 GO:0004126 cytidine deaminase activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0004859 phospholipase inhibitor activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0005025 transforming growth factor beta receptor activity, type I 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0005026 transforming growth factor beta receptor activity, type II 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0005078 MAP-kinase scaffold activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0005095 GTPase inhibitor activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0005247 voltage-gated chloride channel activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0005527 macrolide binding 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0008504 monoamine transmembrane transporter activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0015132 prostaglandin transmembrane transporter activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0015166 polyol transmembrane transporter activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0015269 calcium-activated potassium channel activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0015368 calcium:monoatomic cation antiporter activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0016361 activin receptor activity, type I 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0016362 activin receptor activity, type II 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0016801 hydrolase activity, acting on ether bonds 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0016803 ether hydrolase activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0017002 activin receptor activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0031543 peptidyl-proline dioxygenase activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0042301 phosphate ion binding 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0043047 single-stranded telomeric DNA binding 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0097677 STAT family protein binding 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:1990459 transferrin receptor binding 2/2065 12/18639 0.166666666666667 1.5043583535109 0.390283406352929 0.739536723040286 GO:0140463 chromatin-protein adaptor activity 7/2065 54/18639 0.12962962962963 1.17005649717514 0.390519370379789 0.739536723040286 GO:0005179 hormone activity 16/2065 132/18639 0.121212121212121 1.09407880255338 0.390849344684885 0.739536723040286 GO:0019213 deacetylase activity 5/2065 37/18639 0.135135135135135 1.21975001636019 0.391484916085612 0.739536723040286 GO:0042805 actinin binding 5/2065 37/18639 0.135135135135135 1.21975001636019 0.391484916085612 0.739536723040286 GO:0070001 aspartic-type peptidase activity 5/2065 37/18639 0.135135135135135 1.21975001636019 0.391484916085612 0.739536723040286 GO:0004181 metallocarboxypeptidase activity 4/2065 29/18639 0.137931034482759 1.24498622359522 0.402989287179465 0.757860450516606 GO:0005416 amino acid:monoatomic cation symporter activity 4/2065 29/18639 0.137931034482759 1.24498622359522 0.402989287179465 0.757860450516606 GO:0016417 S-acyltransferase activity 4/2065 29/18639 0.137931034482759 1.24498622359522 0.402989287179465 0.757860450516606 GO:0015294 solute:monoatomic cation symporter activity 14/2065 116/18639 0.120689655172414 1.08936294564582 0.40943075283734 0.768826748994111 GO:0005319 lipid transporter activity 21/2065 178/18639 0.117977528089888 1.06488287945153 0.41431346407911 0.774191835132241 GO:0042887 amide transmembrane transporter activity 5/2065 38/18639 0.131578947368421 1.18765133171913 0.414389646497301 0.774191835132241 GO:0001846 opsonin binding 3/2065 21/18639 0.142857142857143 1.28945001729505 0.415974501892482 0.774191835132241 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2065 21/18639 0.142857142857143 1.28945001729505 0.415974501892482 0.774191835132241 GO:0015174 basic amino acid transmembrane transporter activity 3/2065 21/18639 0.142857142857143 1.28945001729505 0.415974501892482 0.774191835132241 GO:0051428 peptide hormone receptor binding 3/2065 21/18639 0.142857142857143 1.28945001729505 0.415974501892482 0.774191835132241 GO:0140359 ABC-type transporter activity 6/2065 47/18639 0.127659574468085 1.15227448354026 0.422343415430553 0.778737352757081 GO:0019208 phosphatase regulator activity 14/2065 117/18639 0.11965811965812 1.08005215123859 0.422382886937202 0.778737352757081 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/2065 30/18639 0.133333333333333 1.20348668280872 0.429005204983682 0.778737352757081 GO:0022839 monoatomic ion-gated channel activity 4/2065 30/18639 0.133333333333333 1.20348668280872 0.429005204983682 0.778737352757081 GO:0031210 phosphatidylcholine binding 4/2065 30/18639 0.133333333333333 1.20348668280872 0.429005204983682 0.778737352757081 GO:0033612 receptor serine/threonine kinase binding 4/2065 30/18639 0.133333333333333 1.20348668280872 0.429005204983682 0.778737352757081 GO:0048019 receptor antagonist activity 4/2065 30/18639 0.133333333333333 1.20348668280872 0.429005204983682 0.778737352757081 GO:0051721 protein phosphatase 2A binding 4/2065 30/18639 0.133333333333333 1.20348668280872 0.429005204983682 0.778737352757081 GO:0004465 lipoprotein lipase activity 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0005035 death receptor activity 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0005172 vascular endothelial growth factor receptor binding 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0008253 5'-nucleotidase activity 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0017154 semaphorin receptor activity 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0031432 titin binding 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0035673 oligopeptide transmembrane transporter activity 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0043560 insulin receptor substrate binding 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0061459 L-arginine transmembrane transporter activity 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0089720 caspase binding 2/2065 13/18639 0.153846153846154 1.3886384801639 0.430777726088639 0.778737352757081 GO:0005539 glycosaminoglycan binding 28/2065 242/18639 0.115702479338843 1.04434794789186 0.433470286583638 0.782482179219747 GO:0017171 serine hydrolase activity 23/2065 198/18639 0.116161616161616 1.04849218578032 0.437715460328026 0.789014992865969 GO:0005125 cytokine activity 27/2065 234/18639 0.115384615384615 1.04147886012293 0.441678287479152 0.795020917462474 GO:0008093 cytoskeletal anchor activity 3/2065 22/18639 0.136363636363636 1.23083865287255 0.446669827439984 0.799437475247699 GO:0015377 chloride:monoatomic cation symporter activity 3/2065 22/18639 0.136363636363636 1.23083865287255 0.446669827439984 0.799437475247699 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/2065 22/18639 0.136363636363636 1.23083865287255 0.446669827439984 0.799437475247699 GO:0140517 protein-RNA adaptor activity 3/2065 22/18639 0.136363636363636 1.23083865287255 0.446669827439984 0.799437475247699 GO:0008327 methyl-CpG binding 4/2065 31/18639 0.129032258064516 1.16466453175037 0.454710294386313 0.811285041850783 GO:0016411 acylglycerol O-acyltransferase activity 4/2065 31/18639 0.129032258064516 1.16466453175037 0.454710294386313 0.811285041850783 GO:0004527 exonuclease activity 10/2065 84/18639 0.119047619047619 1.07454168107921 0.455221051260717 0.811285041850783 GO:0015144 carbohydrate transmembrane transporter activity 5/2065 40/18639 0.125 1.12826876513317 0.45971064313349 0.813094089512212 GO:0030331 nuclear estrogen receptor binding 5/2065 40/18639 0.125 1.12826876513317 0.45971064313349 0.813094089512212 GO:0050997 quaternary ammonium group binding 5/2065 40/18639 0.125 1.12826876513317 0.45971064313349 0.813094089512212 GO:0016763 pentosyltransferase activity 6/2065 49/18639 0.122448979591837 1.10524287196719 0.463174377426092 0.813094089512212 GO:0015085 calcium ion transmembrane transporter activity 17/2065 147/18639 0.115646258503401 1.04384049019123 0.464063162263803 0.813094089512212 GO:0004065 arylsulfatase activity 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0005161 platelet-derived growth factor receptor binding 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0005313 L-glutamate transmembrane transporter activity 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0008195 phosphatidate phosphatase activity 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0008474 palmitoyl-(protein) hydrolase activity 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0008494 translation activator activity 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0019992 diacylglycerol binding 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0032036 myosin heavy chain binding 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0043176 amine binding 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0044548 S100 protein binding 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0070742 C2H2 zinc finger domain binding 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0098599 palmitoyl hydrolase activity 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0098821 BMP receptor activity 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0098847 sequence-specific single stranded DNA binding 2/2065 14/18639 0.142857142857143 1.28945001729505 0.469787696162611 0.813094089512212 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/2065 23/18639 0.130434782608696 1.17732392883461 0.476694924173228 0.820540443248999 GO:0016493 C-C chemokine receptor activity 3/2065 23/18639 0.130434782608696 1.17732392883461 0.476694924173228 0.820540443248999 GO:0031681 G-protein beta-subunit binding 3/2065 23/18639 0.130434782608696 1.17732392883461 0.476694924173228 0.820540443248999 GO:0070577 lysine-acetylated histone binding 3/2065 23/18639 0.130434782608696 1.17732392883461 0.476694924173228 0.820540443248999 GO:0042910 xenobiotic transmembrane transporter activity 4/2065 32/18639 0.125 1.12826876513317 0.480017392609629 0.822886958759363 GO:0051059 NF-kappaB binding 4/2065 32/18639 0.125 1.12826876513317 0.480017392609629 0.822886958759363 GO:0120015 sterol transfer activity 4/2065 32/18639 0.125 1.12826876513317 0.480017392609629 0.822886958759363 GO:0001727 lipid kinase activity 5/2065 41/18639 0.121951219512195 1.10075001476407 0.481997642461733 0.824039388740547 GO:0140828 metal cation:monoatomic cation antiporter activity 5/2065 41/18639 0.121951219512195 1.10075001476407 0.481997642461733 0.824039388740547 GO:0005262 calcium channel activity 15/2065 131/18639 0.114503816793893 1.03352863981665 0.487108696426377 0.828797455462368 GO:0008236 serine-type peptidase activity 22/2065 194/18639 0.11340206185567 1.02358403434762 0.487646107661793 0.828797455462368 GO:0043021 ribonucleoprotein complex binding 20/2065 177/18639 0.112994350282486 1.01990396848196 0.498223727222418 0.828797455462368 GO:0019199 transmembrane receptor protein kinase activity 9/2065 78/18639 0.115384615384615 1.04147886012293 0.50156207992776 0.828797455462368 GO:0001098 basal transcription machinery binding 7/2065 60/18639 0.116666666666667 1.05305084745763 0.502590101341831 0.828797455462368 GO:0001099 basal RNA polymerase II transcription machinery binding 7/2065 60/18639 0.116666666666667 1.05305084745763 0.502590101341831 0.828797455462368 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2065 60/18639 0.116666666666667 1.05305084745763 0.502590101341831 0.828797455462368 GO:0005048 signal sequence binding 6/2065 51/18639 0.117647058823529 1.06190001424299 0.503218845397333 0.828797455462368 GO:0030544 Hsp70 protein binding 6/2065 51/18639 0.117647058823529 1.06190001424299 0.503218845397333 0.828797455462368 GO:0035198 miRNA binding 5/2065 42/18639 0.119047619047619 1.07454168107921 0.503958559779942 0.828797455462368 GO:0005315 phosphate transmembrane transporter activity 3/2065 24/18639 0.125 1.12826876513317 0.505937090104246 0.828797455462368 GO:0030552 cAMP binding 3/2065 24/18639 0.125 1.12826876513317 0.505937090104246 0.828797455462368 GO:0070300 phosphatidic acid binding 3/2065 24/18639 0.125 1.12826876513317 0.505937090104246 0.828797455462368 GO:0140612 DNA damage sensor activity 3/2065 24/18639 0.125 1.12826876513317 0.505937090104246 0.828797455462368 GO:0004089 carbonate dehydratase activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0004129 cytochrome-c oxidase activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0004953 icosanoid receptor activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0005523 tropomyosin binding 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0008252 nucleotidase activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0010181 FMN binding 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0015250 water channel activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0016846 carbon-sulfur lyase activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0031386 protein tag activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0033130 acetylcholine receptor binding 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0042809 nuclear vitamin D receptor binding 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0045504 dynein heavy chain binding 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0050780 dopamine receptor binding 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0051371 muscle alpha-actinin binding 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0141047 molecular tag activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0141050 histone H3K deacetylase activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0141051 histone H4K deacetylase activity 2/2065 15/18639 0.133333333333333 1.20348668280872 0.507145109651973 0.828797455462368 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/2065 52/18639 0.115384615384615 1.04147886012293 0.522839707758125 0.853339419397977 GO:0019888 protein phosphatase regulator activity 12/2065 107/18639 0.11214953271028 1.01227851825032 0.527759879408478 0.860255430859874 GO:0030332 cyclin binding 4/2065 34/18639 0.117647058823529 1.06190001424299 0.529138788398292 0.861388725299545 GO:0005537 D-mannose binding 3/2065 25/18639 0.12 1.08313801452784 0.534303983234781 0.865631499466857 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/2065 25/18639 0.12 1.08313801452784 0.534303983234781 0.865631499466857 GO:0017025 TBP-class protein binding 3/2065 25/18639 0.12 1.08313801452784 0.534303983234781 0.865631499466857 GO:0008201 heparin binding 19/2065 172/18639 0.11046511627907 0.997074722675826 0.541697891079595 0.865631499466857 GO:0004864 protein phosphatase inhibitor activity 6/2065 53/18639 0.113207547169811 1.02182831559231 0.542143142074672 0.865631499466857 GO:0004707 MAP kinase activity 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0004708 MAP kinase kinase activity 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0008296 3'-5'-DNA exonuclease activity 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0015378 sodium:chloride symporter activity 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0019841 retinol binding 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0030275 LRR domain binding 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0097027 ubiquitin-protein transferase activator activity 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0140327 flippase activity 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0140328 floppase activity 2/2065 16/18639 0.125 1.12826876513317 0.542737209983188 0.865631499466857 GO:0030547 signaling receptor inhibitor activity 5/2065 44/18639 0.113636363636364 1.02569887739379 0.546703882760538 0.870855742450414 GO:0016829 lyase activity 22/2065 200/18639 0.11 0.992876513317191 0.547967725924943 0.871766836698773 GO:0004386 helicase activity 17/2065 155/18639 0.109677419354839 0.989964851987815 0.555842097005058 0.883179120083699 GO:0003925 G protein activity 6/2065 54/18639 0.111111111111111 1.00290556900726 0.561096113536531 0.888042176472845 GO:0030247 polysaccharide binding 3/2065 26/18639 0.115384615384615 1.04147886012293 0.561721916387982 0.888042176472845 GO:0030507 spectrin binding 3/2065 26/18639 0.115384615384615 1.04147886012293 0.561721916387982 0.888042176472845 GO:0051139 metal cation:proton antiporter activity 3/2065 26/18639 0.115384615384615 1.04147886012293 0.561721916387982 0.888042176472845 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/2065 36/18639 0.111111111111111 1.00290556900726 0.575867139867065 0.902342314397648 GO:0045505 dynein intermediate chain binding 4/2065 36/18639 0.111111111111111 1.00290556900726 0.575867139867065 0.902342314397648 GO:0015278 intracellularly gated calcium channel activity 2/2065 17/18639 0.117647058823529 1.06190001424299 0.576496478642942 0.902342314397648 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/2065 17/18639 0.117647058823529 1.06190001424299 0.576496478642942 0.902342314397648 GO:0017110 nucleoside diphosphate phosphatase activity 2/2065 17/18639 0.117647058823529 1.06190001424299 0.576496478642942 0.902342314397648 GO:0031489 myosin V binding 2/2065 17/18639 0.117647058823529 1.06190001424299 0.576496478642942 0.902342314397648 GO:0038191 neuropilin binding 2/2065 17/18639 0.117647058823529 1.06190001424299 0.576496478642942 0.902342314397648 GO:0051787 misfolded protein binding 2/2065 17/18639 0.117647058823529 1.06190001424299 0.576496478642942 0.902342314397648 GO:0008374 O-acyltransferase activity 6/2065 55/18639 0.109090909090909 0.984670922298041 0.579669032825677 0.906182359007883 GO:0015252 proton channel activity 3/2065 27/18639 0.111111111111111 1.00290556900726 0.588134122691114 0.917139844790598 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/2065 27/18639 0.111111111111111 1.00290556900726 0.588134122691114 0.917139844790598 GO:0140658 ATP-dependent chromatin remodeler activity 17/2065 158/18639 0.107594936708861 0.971168051000705 0.588923273999312 0.917235259875319 GO:0003697 single-stranded DNA binding 13/2065 121/18639 0.107438016528926 0.969751665899586 0.590023538111681 0.917814392618171 GO:0005201 extracellular matrix structural constituent 18/2065 168/18639 0.107142857142857 0.96708751297129 0.596787436892266 0.92719133228638 GO:0019212 phosphatase inhibitor activity 6/2065 56/18639 0.107142857142857 0.96708751297129 0.597835694490466 0.927521202523972 GO:0031072 heat shock protein binding 14/2065 131/18639 0.106870229007634 0.964626730495536 0.598472014009515 0.927521202523972 GO:0140938 histone H3 methyltransferase activity 5/2065 47/18639 0.106382978723404 0.960228736283551 0.607277872821159 0.931438547192523 GO:0000400 four-way junction DNA binding 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0005372 water transmembrane transporter activity 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0008308 voltage-gated monoatomic anion channel activity 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0008525 phosphatidylcholine transporter activity 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0015280 ligand-gated sodium channel activity 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0015373 monoatomic anion:sodium symporter activity 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0031690 adrenergic receptor binding 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/2065 18/18639 0.111111111111111 1.00290556900726 0.608392003444005 0.931438547192523 GO:0045499 chemorepellent activity 3/2065 28/18639 0.107142857142857 0.96708751297129 0.613499036481259 0.935845987852768 GO:0050698 proteoglycan sulfotransferase activity 3/2065 28/18639 0.107142857142857 0.96708751297129 0.613499036481259 0.935845987852768 GO:0097718 disordered domain specific binding 3/2065 28/18639 0.107142857142857 0.96708751297129 0.613499036481259 0.935845987852768 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2065 57/18639 0.105263157894737 0.950121065375303 0.615573191624726 0.937874512027998 GO:0004867 serine-type endopeptidase inhibitor activity 10/2065 95/18639 0.105263157894737 0.950121065375303 0.61686366162378 0.938705572036187 GO:0000146 microfilament motor activity 4/2065 38/18639 0.105263157894737 0.950121065375303 0.619843189011084 0.9409667688602 GO:0043531 ADP binding 4/2065 38/18639 0.105263157894737 0.950121065375303 0.619843189011084 0.9409667688602 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/2065 67/18639 0.104477611940299 0.943030609663547 0.623260090898039 0.945015300278615 GO:0032266 phosphatidylinositol-3-phosphate binding 5/2065 48/18639 0.104166666666667 0.94022397094431 0.626399228152668 0.948633446481204 GO:0008083 growth factor activity 17/2065 162/18639 0.104938271604938 0.947188592951305 0.631380950800633 0.954152420238121 GO:0046873 metal ion transmembrane transporter activity 48/2065 450/18639 0.106666666666667 0.962789346246973 0.633635706407892 0.954152420238121 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 19/2065 181/18639 0.104972375690608 0.947496421548299 0.634121773297841 0.954152420238121 GO:0099604 ligand-gated calcium channel activity 3/2065 29/18639 0.103448275862069 0.933739667696418 0.637788622939158 0.954152420238121 GO:0005229 intracellularly calcium-gated chloride channel activity 2/2065 19/18639 0.105263157894737 0.950121065375303 0.638422202725046 0.954152420238121 GO:0008301 DNA binding, bending 2/2065 19/18639 0.105263157894737 0.950121065375303 0.638422202725046 0.954152420238121 GO:0008381 mechanosensitive monoatomic ion channel activity 2/2065 19/18639 0.105263157894737 0.950121065375303 0.638422202725046 0.954152420238121 GO:0016918 retinal binding 2/2065 19/18639 0.105263157894737 0.950121065375303 0.638422202725046 0.954152420238121 GO:0042577 lipid phosphatase activity 2/2065 19/18639 0.105263157894737 0.950121065375303 0.638422202725046 0.954152420238121 GO:0141147 intracellularly calcium-gated channel activity 2/2065 19/18639 0.105263157894737 0.950121065375303 0.638422202725046 0.954152420238121 GO:0003777 microtubule motor activity 7/2065 68/18639 0.102941176470588 0.929162512462612 0.639130668794424 0.954152420238121 GO:0030145 manganese ion binding 7/2065 68/18639 0.102941176470588 0.929162512462612 0.639130668794424 0.954152420238121 GO:0000217 DNA secondary structure binding 4/2065 39/18639 0.102564102564103 0.925758986775936 0.640721953398117 0.954266739103578 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/2065 39/18639 0.102564102564103 0.925758986775936 0.640721953398117 0.954266739103578 GO:0005506 iron ion binding 16/2065 154/18639 0.103896103896104 0.937781830760039 0.645894641297756 0.960835003583438 GO:0046982 protein heterodimerization activity 39/2065 369/18639 0.105691056910569 0.953983346128861 0.648434007085696 0.963475057698087 GO:0070063 RNA polymerase binding 6/2065 59/18639 0.101694915254237 0.917913571633767 0.649684907647619 0.963762678841636 GO:0015370 solute:sodium symporter activity 8/2065 79/18639 0.10126582278481 0.914040518588899 0.659565004404937 0.963762678841636 GO:0016835 carbon-oxygen lyase activity 8/2065 79/18639 0.10126582278481 0.914040518588899 0.659565004404937 0.963762678841636 GO:0004532 RNA exonuclease activity 4/2065 40/18639 0.1 0.902615012106538 0.660834321205298 0.963762678841636 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/2065 40/18639 0.1 0.902615012106538 0.660834321205298 0.963762678841636 GO:0001968 fibronectin binding 3/2065 30/18639 0.1 0.902615012106538 0.660986780489766 0.963762678841636 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2065 30/18639 0.1 0.902615012106538 0.660986780489766 0.963762678841636 GO:0016769 transferase activity, transferring nitrogenous groups 3/2065 30/18639 0.1 0.902615012106538 0.660986780489766 0.963762678841636 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6/2065 60/18639 0.1 0.902615012106538 0.666028775014929 0.963762678841636 GO:0005326 neurotransmitter transmembrane transporter activity 2/2065 20/18639 0.1 0.902615012106538 0.666608711199886 0.963762678841636 GO:0010851 cyclase regulator activity 2/2065 20/18639 0.1 0.902615012106538 0.666608711199886 0.963762678841636 GO:0030742 GTP-dependent protein binding 2/2065 20/18639 0.1 0.902615012106538 0.666608711199886 0.963762678841636 GO:0061608 nuclear import signal receptor activity 2/2065 20/18639 0.1 0.902615012106538 0.666608711199886 0.963762678841636 GO:0140664 ATP-dependent DNA damage sensor activity 2/2065 20/18639 0.1 0.902615012106538 0.666608711199886 0.963762678841636 GO:0004252 serine-type endopeptidase activity 18/2065 176/18639 0.102272727272727 0.923128989654413 0.676573912015824 0.963762678841636 GO:0017080 sodium channel regulator activity 4/2065 41/18639 0.0975609756097561 0.880600011811256 0.680168016204602 0.963762678841636 GO:0003743 translation initiation factor activity 5/2065 51/18639 0.0980392156862745 0.884916678535821 0.68026379178685 0.963762678841636 GO:0005452 solute:inorganic anion antiporter activity 3/2065 31/18639 0.0967741935483871 0.873498398812778 0.683087832572279 0.963762678841636 GO:0070273 phosphatidylinositol-4-phosphate binding 3/2065 31/18639 0.0967741935483871 0.873498398812778 0.683087832572279 0.963762678841636 GO:0072349 modified amino acid transmembrane transporter activity 3/2065 31/18639 0.0967741935483871 0.873498398812778 0.683087832572279 0.963762678841636 GO:0000182 rDNA binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0003796 lysozyme activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0005031 tumor necrosis factor receptor activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0005337 nucleoside transmembrane transporter activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0005522 profilin binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0005528 FK506 binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0008190 eukaryotic initiation factor 4E binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0008239 dipeptidyl-peptidase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0016783 sulfurtransferase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0016868 intramolecular phosphotransferase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0019911 structural constituent of myelin sheath 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0031720 haptoglobin binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0031996 thioesterase binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0032052 bile acid binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0042975 peroxisome proliferator activated receptor binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0043208 glycosphingolipid binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0070739 protein-glutamic acid ligase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0070740 tubulin-glutamic acid ligase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0098505 G-rich strand telomeric DNA binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0099122 RNA polymerase II C-terminal domain binding 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0140940 histone H2A methyltransferase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0141109 transporter activator activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:1990259 histone H2AQ104 methyltransferase activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:1990757 ubiquitin ligase activator activity 1/2065 10/18639 0.1 0.902615012106538 0.691029811835377 0.963762678841636 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2065 21/18639 0.0952380952380952 0.859633344863369 0.692991259548034 0.963762678841636 GO:0008373 sialyltransferase activity 2/2065 21/18639 0.0952380952380952 0.859633344863369 0.692991259548034 0.963762678841636 GO:0010314 phosphatidylinositol-5-phosphate binding 2/2065 21/18639 0.0952380952380952 0.859633344863369 0.692991259548034 0.963762678841636 GO:0015125 bile acid transmembrane transporter activity 2/2065 21/18639 0.0952380952380952 0.859633344863369 0.692991259548034 0.963762678841636 GO:0019200 carbohydrate kinase activity 2/2065 21/18639 0.0952380952380952 0.859633344863369 0.692991259548034 0.963762678841636 GO:0036122 BMP binding 2/2065 21/18639 0.0952380952380952 0.859633344863369 0.692991259548034 0.963762678841636 GO:0072542 protein phosphatase activator activity 2/2065 21/18639 0.0952380952380952 0.859633344863369 0.692991259548034 0.963762678841636 GO:0004520 DNA endonuclease activity 4/2065 42/18639 0.0952380952380952 0.859633344863369 0.698716380038777 0.966094164260058 GO:0043175 RNA polymerase core enzyme binding 4/2065 42/18639 0.0952380952380952 0.859633344863369 0.698716380038777 0.966094164260058 GO:0015108 chloride transmembrane transporter activity 12/2065 121/18639 0.0991735537190083 0.89515538390731 0.700902899504794 0.966094164260058 GO:0051082 unfolded protein binding 12/2065 121/18639 0.0991735537190083 0.89515538390731 0.700902899504794 0.966094164260058 GO:0140142 nucleocytoplasmic carrier activity 3/2065 32/18639 0.09375 0.846201573849879 0.704095119464967 0.966094164260058 GO:0000510 H3-H4 histone complex chaperone activity 15/2065 151/18639 0.0993377483443709 0.896637429244905 0.711457492435652 0.966094164260058 GO:0140584 chromatin extrusion motor activity 15/2065 151/18639 0.0993377483443709 0.896637429244905 0.711457492435652 0.966094164260058 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 15/2065 151/18639 0.0993377483443709 0.896637429244905 0.711457492435652 0.966094164260058 GO:0140849 ATP-dependent H2AZ histone chaperone activity 15/2065 151/18639 0.0993377483443709 0.896637429244905 0.711457492435652 0.966094164260058 GO:1901682 sulfur compound transmembrane transporter activity 6/2065 63/18639 0.0952380952380952 0.859633344863369 0.712088795058088 0.966094164260058 GO:0008135 translation factor activity, RNA binding 8/2065 83/18639 0.0963855421686747 0.869990373114735 0.713536720463333 0.966094164260058 GO:0042393 histone binding 25/2065 247/18639 0.101214574898785 0.913577947476253 0.714768079893284 0.966094164260058 GO:0004518 nuclease activity 21/2065 209/18639 0.100478468899522 0.90693374422188 0.715532519737099 0.966094164260058 GO:0004407 histone deacetylase activity 2/2065 22/18639 0.0909090909090909 0.820559101915034 0.717623402758839 0.966094164260058 GO:0033558 protein lysine deacetylase activity 2/2065 22/18639 0.0909090909090909 0.820559101915034 0.717623402758839 0.966094164260058 GO:0015616 DNA translocase activity 15/2065 152/18639 0.0986842105263158 0.890738498789346 0.720956688949096 0.966094164260058 GO:0046906 tetrapyrrole binding 15/2065 152/18639 0.0986842105263158 0.890738498789346 0.720956688949096 0.966094164260058 GO:0140674 ATP-dependent histone chaperone activity 15/2065 152/18639 0.0986842105263158 0.890738498789346 0.720956688949096 0.966094164260058 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0002162 dystroglycan binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0003953 NAD+ nucleosidase activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0004016 adenylate cyclase activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0005536 D-glucose binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0008046 axon guidance receptor activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0008172 S-methyltransferase activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0008271 secondary active sulfate transmembrane transporter activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0008503 benzodiazepine receptor activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0015173 aromatic amino acid transmembrane transporter activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0031731 CCR6 chemokine receptor binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0034056 estrogen response element binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0048407 platelet-derived growth factor binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0050998 nitric-oxide synthase binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0070990 snRNP binding 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/2065 11/18639 0.0909090909090909 0.820559101915034 0.725278748362295 0.966094164260058 GO:0031491 nucleosome binding 7/2065 74/18639 0.0945945945945946 0.85382501145213 0.725766060514165 0.966094164260058 GO:0180051 translation factor activity 8/2065 84/18639 0.0952380952380952 0.859633344863369 0.726104105995457 0.966094164260058 GO:0042562 hormone binding 9/2065 94/18639 0.0957446808510638 0.864205862655196 0.727115407583093 0.966419212610441 GO:0061775 cohesin loader activity 15/2065 153/18639 0.0980392156862745 0.884916678535821 0.730259356217009 0.969575119950929 GO:0044183 protein folding chaperone 7/2065 75/18639 0.0933333333333333 0.842440677966102 0.738711434603856 0.970666072026059 GO:0120013 lipid transfer activity 6/2065 65/18639 0.0923076923076923 0.833183088098342 0.740266190438004 0.970666072026059 GO:0005212 structural constituent of eye lens 2/2065 23/18639 0.0869565217391304 0.784882619223076 0.740568972147944 0.970666072026059 GO:0016849 phosphorus-oxygen lyase activity 2/2065 23/18639 0.0869565217391304 0.784882619223076 0.740568972147944 0.970666072026059 GO:0017134 fibroblast growth factor binding 2/2065 23/18639 0.0869565217391304 0.784882619223076 0.740568972147944 0.970666072026059 GO:0042171 lysophosphatidic acid acyltransferase activity 2/2065 23/18639 0.0869565217391304 0.784882619223076 0.740568972147944 0.970666072026059 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/2065 23/18639 0.0869565217391304 0.784882619223076 0.740568972147944 0.970666072026059 GO:0071617 lysophospholipid acyltransferase activity 2/2065 23/18639 0.0869565217391304 0.784882619223076 0.740568972147944 0.970666072026059 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/2065 23/18639 0.0869565217391304 0.784882619223076 0.740568972147944 0.970666072026059 GO:0015081 sodium ion transmembrane transporter activity 16/2065 164/18639 0.0975609756097561 0.880600011811256 0.741829195976727 0.970666072026059 GO:0008376 acetylgalactosaminyltransferase activity 3/2065 34/18639 0.0882352941176471 0.796425010682239 0.742879138877131 0.970666072026059 GO:0015035 protein-disulfide reductase activity 3/2065 34/18639 0.0882352941176471 0.796425010682239 0.742879138877131 0.970666072026059 GO:0019825 oxygen binding 3/2065 34/18639 0.0882352941176471 0.796425010682239 0.742879138877131 0.970666072026059 GO:0015103 inorganic anion transmembrane transporter activity 16/2065 165/18639 0.096969696969697 0.875263042042703 0.750425050904048 0.970666072026059 GO:0000340 RNA 7-methylguanosine cap binding 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0003995 acyl-CoA dehydrogenase activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0004300 enoyl-CoA hydratase activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0005049 nuclear export signal receptor activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0005436 sodium:phosphate symporter activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0008179 adenylate cyclase binding 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0010853 cyclase activator activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0016273 arginine N-methyltransferase activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0016274 protein-arginine N-methyltransferase activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0035251 UDP-glucosyltransferase activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0036009 protein-glutamine N-methyltransferase activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0045295 gamma-catenin binding 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0140900 chloride:bicarbonate antiporter activity 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/2065 12/18639 0.0833333333333333 0.752179176755448 0.755732870363146 0.970666072026059 GO:0030170 pyridoxal phosphate binding 5/2065 56/18639 0.0892857142857143 0.805906260809409 0.757843417425388 0.970810735045657 GO:0043015 gamma-tubulin binding 3/2065 35/18639 0.0857142857142857 0.773670010377032 0.760696459244496 0.970810735045657 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/2065 24/18639 0.0833333333333333 0.752179176755448 0.761899143242826 0.970810735045657 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/2065 24/18639 0.0833333333333333 0.752179176755448 0.761899143242826 0.970810735045657 GO:0005540 hyaluronic acid binding 2/2065 24/18639 0.0833333333333333 0.752179176755448 0.761899143242826 0.970810735045657 GO:0048027 mRNA 5'-UTR binding 2/2065 24/18639 0.0833333333333333 0.752179176755448 0.761899143242826 0.970810735045657 GO:0070840 dynein complex binding 2/2065 24/18639 0.0833333333333333 0.752179176755448 0.761899143242826 0.970810735045657 GO:0003724 RNA helicase activity 7/2065 77/18639 0.0909090909090909 0.820559101915034 0.763300161087638 0.970810735045657 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4/2065 46/18639 0.0869565217391304 0.784882619223076 0.765088915259836 0.970810735045657 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/2065 46/18639 0.0869565217391304 0.784882619223076 0.765088915259836 0.970810735045657 GO:0050840 extracellular matrix binding 6/2065 67/18639 0.0895522388059701 0.808311951140183 0.7664113161004 0.970810735045657 GO:0070279 vitamin B6 binding 5/2065 57/18639 0.087719298245614 0.791767554479419 0.771523246829298 0.970810735045657 GO:0000993 RNA polymerase II complex binding 3/2065 36/18639 0.0833333333333333 0.752179176755448 0.777499124642445 0.970810735045657 GO:0005548 phospholipid transporter activity 6/2065 68/18639 0.0882352941176471 0.796425010682239 0.778728798097752 0.970810735045657 GO:0043495 protein-membrane adaptor activity 4/2065 47/18639 0.0851063829787234 0.76818298902684 0.779769012230876 0.970810735045657 GO:0008509 monoatomic anion transmembrane transporter activity 14/2065 149/18639 0.0939597315436242 0.848094642247753 0.78099003834952 0.970810735045657 GO:0008483 transaminase activity 2/2065 25/18639 0.08 0.72209200968523 0.781690026721787 0.970810735045657 GO:0019211 phosphatase activator activity 2/2065 25/18639 0.08 0.72209200968523 0.781690026721787 0.970810735045657 GO:0004535 poly(A)-specific ribonuclease activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0008417 fucosyltransferase activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0030955 potassium ion binding 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0039706 co-receptor binding 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0045159 myosin II binding 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0046974 histone H3K9 methyltransferase activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0046975 histone H3K36 methyltransferase activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0051011 microtubule minus-end binding 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0070700 BMP receptor binding 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0097157 pre-mRNA intronic binding 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0140333 glycerophospholipid flippase activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0140666 annealing activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0140852 histone ubiquitin ligase activity 1/2065 13/18639 0.0769230769230769 0.694319240081952 0.782812465719355 0.970810735045657 GO:0008408 3'-5' exonuclease activity 5/2065 58/18639 0.0862068965517241 0.778116389747015 0.784604514418799 0.972076389545415 GO:0008186 ATP-dependent activity, acting on RNA 7/2065 79/18639 0.0886075949367089 0.799785453765286 0.786163773903469 0.973051429389363 GO:0019842 vitamin binding 14/2065 150/18639 0.0933333333333333 0.842440677966102 0.789145639662348 0.975575606920023 GO:0003689 DNA clamp loader activity 15/2065 160/18639 0.09375 0.846201573849879 0.7897516817924 0.975575606920023 GO:0030280 structural constituent of skin epidermis 3/2065 37/18639 0.0810810810810811 0.731850009816112 0.793318179729241 0.978063509255228 GO:0030551 cyclic nucleotide binding 3/2065 37/18639 0.0810810810810811 0.731850009816112 0.793318179729241 0.978063509255228 GO:0140104 molecular carrier activity 24/2065 249/18639 0.0963855421686747 0.869990373114735 0.79471871938644 0.978209611389437 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/2065 26/18639 0.0769230769230769 0.694319240081952 0.800020702582937 0.978209611389437 GO:0015145 monosaccharide transmembrane transporter activity 2/2065 26/18639 0.0769230769230769 0.694319240081952 0.800020702582937 0.978209611389437 GO:0020037 heme binding 13/2065 142/18639 0.0915492957746479 0.826337687139788 0.804969102867438 0.978209611389437 GO:0004705 JUN kinase activity 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0005344 oxygen carrier activity 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0008559 ABC-type xenobiotic transporter activity 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0031404 chloride ion binding 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0042043 neurexin family protein binding 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0042813 Wnt receptor activity 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0061783 peptidoglycan muralytic activity 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/2065 14/18639 0.0714285714285714 0.644725008647527 0.806891294146797 0.978209611389437 GO:0043022 ribosome binding 10/2065 112/18639 0.0892857142857143 0.805906260809409 0.807877993018352 0.978209611389437 GO:0005109 frizzled binding 3/2065 38/18639 0.0789473684210526 0.712590799031477 0.80818746464794 0.978209611389437 GO:0005501 retinoid binding 3/2065 38/18639 0.0789473684210526 0.712590799031477 0.80818746464794 0.978209611389437 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/2065 38/18639 0.0789473684210526 0.712590799031477 0.80818746464794 0.978209611389437 GO:0019840 isoprenoid binding 3/2065 38/18639 0.0789473684210526 0.712590799031477 0.80818746464794 0.978209611389437 GO:0042162 telomeric DNA binding 3/2065 38/18639 0.0789473684210526 0.712590799031477 0.80818746464794 0.978209611389437 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/2065 60/18639 0.0833333333333333 0.752179176755448 0.809012370200078 0.978268317132532 GO:0016887 ATP hydrolysis activity 41/2065 417/18639 0.0983213429256595 0.887463201351752 0.81482858765303 0.979556902186308 GO:0008395 steroid hydroxylase activity 2/2065 27/18639 0.0740740740740741 0.668603712671509 0.816971628974283 0.979556902186308 GO:0005253 monoatomic anion channel activity 9/2065 103/18639 0.087378640776699 0.78869272902513 0.818909521252104 0.979556902186308 GO:0140713 histone chaperone activity 15/2065 164/18639 0.0914634146341463 0.825562511073053 0.819296717821726 0.979556902186308 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/2065 61/18639 0.0819672131147541 0.739848370579129 0.820363252190803 0.979556902186308 GO:0005254 chloride channel activity 7/2065 83/18639 0.0843373493975904 0.761241576475393 0.826850814697587 0.979556902186308 GO:0008194 UDP-glycosyltransferase activity 13/2065 145/18639 0.0896551724137931 0.809241045336896 0.827525503507207 0.979556902186308 GO:0000774 adenyl-nucleotide exchange factor activity 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0015116 sulfate transmembrane transporter activity 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0030553 cGMP binding 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0031005 filamin binding 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0034483 heparan sulfate sulfotransferase activity 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0048531 beta-1,3-galactosyltransferase activity 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0050700 CARD domain binding 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0140161 monocarboxylate:sodium symporter activity 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0140776 protein-containing complex destabilizing activity 1/2065 15/18639 0.0666666666666667 0.601743341404358 0.828301735896427 0.979556902186308 GO:0005010 insulin-like growth factor receptor activity 4/2065 51/18639 0.0784313725490196 0.707933342828657 0.831305884239695 0.979556902186308 GO:0005272 sodium channel activity 4/2065 51/18639 0.0784313725490196 0.707933342828657 0.831305884239695 0.979556902186308 GO:0016597 amino acid binding 4/2065 51/18639 0.0784313725490196 0.707933342828657 0.831305884239695 0.979556902186308 GO:1901681 sulfur compound binding 26/2065 275/18639 0.0945454545454545 0.853381465991635 0.831535386277485 0.979556902186308 GO:0046875 ephrin receptor binding 2/2065 28/18639 0.0714285714285714 0.644725008647527 0.832623366858362 0.979556902186308 GO:0051119 sugar transmembrane transporter activity 2/2065 28/18639 0.0714285714285714 0.644725008647527 0.832623366858362 0.979556902186308 GO:0051393 alpha-actinin binding 2/2065 28/18639 0.0714285714285714 0.644725008647527 0.832623366858362 0.979556902186308 GO:0051537 2 iron, 2 sulfur cluster binding 2/2065 28/18639 0.0714285714285714 0.644725008647527 0.832623366858362 0.979556902186308 GO:0051959 dynein light intermediate chain binding 2/2065 28/18639 0.0714285714285714 0.644725008647527 0.832623366858362 0.979556902186308 GO:0071855 neuropeptide receptor binding 3/2065 40/18639 0.075 0.676961259079903 0.835221999814444 0.981697499781903 GO:0035250 UDP-galactosyltransferase activity 2/2065 29/18639 0.0689655172413793 0.622493111797612 0.847055570111636 0.989478783508999 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2065 16/18639 0.0625 0.564134382566586 0.84733937095731 0.989478783508999 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/2065 16/18639 0.0625 0.564134382566586 0.84733937095731 0.989478783508999 GO:0008142 oxysterol binding 1/2065 16/18639 0.0625 0.564134382566586 0.84733937095731 0.989478783508999 GO:0015562 efflux transmembrane transporter activity 1/2065 16/18639 0.0625 0.564134382566586 0.84733937095731 0.989478783508999 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2065 16/18639 0.0625 0.564134382566586 0.84733937095731 0.989478783508999 GO:0043023 ribosomal large subunit binding 1/2065 16/18639 0.0625 0.564134382566586 0.84733937095731 0.989478783508999 GO:0005003 ephrin receptor activity 4/2065 53/18639 0.0754716981132075 0.681218877061538 0.853056633105525 0.993393121731018 GO:0005005 transmembrane-ephrin receptor activity 4/2065 53/18639 0.0754716981132075 0.681218877061538 0.853056633105525 0.993393121731018 GO:0038064 collagen receptor activity 4/2065 53/18639 0.0754716981132075 0.681218877061538 0.853056633105525 0.993393121731018 GO:0008094 ATP-dependent activity, acting on DNA 19/2065 210/18639 0.0904761904761905 0.816651677620201 0.855057284635956 0.994803489050143 GO:0019894 kinesin binding 3/2065 42/18639 0.0714285714285714 0.644725008647527 0.858905159456324 0.997438249691216 GO:0051879 Hsp90 protein binding 3/2065 42/18639 0.0714285714285714 0.644725008647527 0.858905159456324 0.997438249691216 GO:0070566 adenylyltransferase activity 2/2065 30/18639 0.0666666666666667 0.601743341404358 0.86034619794177 0.998145265972472 GO:0050661 NADP binding 4/2065 54/18639 0.0740740740740741 0.668603712671509 0.863008515254005 0.998145265972472 GO:0004550 nucleoside diphosphate kinase activity 1/2065 17/18639 0.0588235294117647 0.530950007121493 0.864267051726958 0.998145265972472 GO:0030548 acetylcholine receptor regulator activity 1/2065 17/18639 0.0588235294117647 0.530950007121493 0.864267051726958 0.998145265972472 GO:0045125 bioactive lipid receptor activity 1/2065 17/18639 0.0588235294117647 0.530950007121493 0.864267051726958 0.998145265972472 GO:0070492 oligosaccharide binding 1/2065 17/18639 0.0588235294117647 0.530950007121493 0.864267051726958 0.998145265972472 GO:0004222 metalloendopeptidase activity 9/2065 110/18639 0.0818181818181818 0.738503191723531 0.872383339831209 1 GO:0005184 neuropeptide hormone activity 2/2065 31/18639 0.0645161290322581 0.582332265875185 0.872570912794838 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/2065 31/18639 0.0645161290322581 0.582332265875185 0.872570912794838 1 GO:0017147 Wnt-protein binding 2/2065 31/18639 0.0645161290322581 0.582332265875185 0.872570912794838 1 GO:0004540 RNA nuclease activity 10/2065 121/18639 0.0826446280991736 0.745962819922758 0.874847496947475 1 GO:0042054 histone methyltransferase activity 5/2065 67/18639 0.0746268656716418 0.673593292616819 0.877459993602745 1 GO:0017128 phospholipid scramblase activity 1/2065 18/18639 0.0555555555555556 0.501452784503632 0.879318525155367 1 GO:0022851 GABA-gated chloride ion channel activity 1/2065 18/18639 0.0555555555555556 0.501452784503632 0.879318525155367 1 GO:0070628 proteasome binding 1/2065 18/18639 0.0555555555555556 0.501452784503632 0.879318525155367 1 GO:0099602 neurotransmitter receptor regulator activity 1/2065 18/18639 0.0555555555555556 0.501452784503632 0.879318525155367 1 GO:0043014 alpha-tubulin binding 3/2065 44/18639 0.0681818181818182 0.615419326436276 0.87954808972675 1 GO:0008378 galactosyltransferase activity 2/2065 32/18639 0.0625 0.564134382566586 0.883802632350163 1 GO:0015106 bicarbonate transmembrane transporter activity 2/2065 32/18639 0.0625 0.564134382566586 0.883802632350163 1 GO:0022884 macromolecule transmembrane transporter activity 2/2065 32/18639 0.0625 0.564134382566586 0.883802632350163 1 GO:0030515 snoRNA binding 2/2065 32/18639 0.0625 0.564134382566586 0.883802632350163 1 GO:0031369 translation initiation factor binding 2/2065 32/18639 0.0625 0.564134382566586 0.883802632350163 1 GO:0160041 neuropeptide activity 2/2065 32/18639 0.0625 0.564134382566586 0.883802632350163 1 GO:0051539 4 iron, 4 sulfur cluster binding 3/2065 45/18639 0.0666666666666667 0.601743341404358 0.888826135858762 1 GO:0016279 protein-lysine N-methyltransferase activity 5/2065 69/18639 0.072463768115942 0.654068849352563 0.89269783338096 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/2065 19/18639 0.0526315789473684 0.475060532687651 0.892701654179274 1 GO:0004890 GABA-A receptor activity 1/2065 19/18639 0.0526315789473684 0.475060532687651 0.892701654179274 1 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/2065 19/18639 0.0526315789473684 0.475060532687651 0.892701654179274 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/2065 19/18639 0.0526315789473684 0.475060532687651 0.892701654179274 1 GO:0031420 alkali metal ion binding 1/2065 19/18639 0.0526315789473684 0.475060532687651 0.892701654179274 1 GO:0034987 immunoglobulin receptor binding 1/2065 19/18639 0.0526315789473684 0.475060532687651 0.892701654179274 1 GO:0046527 glucosyltransferase activity 1/2065 19/18639 0.0526315789473684 0.475060532687651 0.892701654179274 1 GO:0050145 nucleoside monophosphate kinase activity 1/2065 19/18639 0.0526315789473684 0.475060532687651 0.892701654179274 1 GO:0016874 ligase activity 14/2065 167/18639 0.0838323353293413 0.756683243682127 0.896142007040707 1 GO:0140597 protein carrier chaperone 16/2065 188/18639 0.0851063829787234 0.76818298902684 0.896985056028377 1 GO:0099094 ligand-gated monoatomic cation channel activity 11/2065 136/18639 0.0808823529411765 0.730056259792052 0.899361653647982 1 GO:0016278 lysine N-methyltransferase activity 5/2065 70/18639 0.0714285714285714 0.644725008647527 0.899683723983602 1 GO:0015020 glucuronosyltransferase activity 2/2065 34/18639 0.0588235294117647 0.530950007121493 0.903563213251742 1 GO:0090482 vitamin transmembrane transporter activity 2/2065 34/18639 0.0588235294117647 0.530950007121493 0.903563213251742 1 GO:0036002 pre-mRNA binding 4/2065 59/18639 0.0677966101694915 0.611942381089178 0.904513987896321 1 GO:0070888 E-box binding 4/2065 59/18639 0.0677966101694915 0.611942381089178 0.904513987896321 1 GO:0000339 RNA cap binding 1/2065 20/18639 0.05 0.451307506053269 0.904601282757136 1 GO:0001972 retinoic acid binding 1/2065 20/18639 0.05 0.451307506053269 0.904601282757136 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/2065 20/18639 0.05 0.451307506053269 0.904601282757136 1 GO:0140939 histone H4 methyltransferase activity 1/2065 20/18639 0.05 0.451307506053269 0.904601282757136 1 GO:0061749 forked DNA-dependent helicase activity 3/2065 47/18639 0.0638297872340425 0.57613724177013 0.905483280178237 1 GO:0099095 ligand-gated monoatomic anion channel activity 3/2065 47/18639 0.0638297872340425 0.57613724177013 0.905483280178237 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 3/2065 47/18639 0.0638297872340425 0.57613724177013 0.905483280178237 1 GO:0016853 isomerase activity 15/2065 180/18639 0.0833333333333333 0.752179176755448 0.907301024166523 1 GO:0004519 endonuclease activity 10/2065 127/18639 0.078740157480315 0.710720481973652 0.907954631761793 1 GO:0000175 3'-5'-RNA exonuclease activity 2/2065 35/18639 0.0571428571428571 0.515780006918021 0.912221804403697 1 GO:0004497 monooxygenase activity 8/2065 106/18639 0.0754716981132075 0.681218877061538 0.912356659724257 1 GO:0009378 four-way junction helicase activity 3/2065 48/18639 0.0625 0.564134382566586 0.912934717531829 1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/2065 48/18639 0.0625 0.564134382566586 0.912934717531829 1 GO:0036121 double-stranded DNA helicase activity 3/2065 48/18639 0.0625 0.564134382566586 0.912934717531829 1 GO:0043138 3'-5' DNA helicase activity 3/2065 48/18639 0.0625 0.564134382566586 0.912934717531829 1 GO:0005248 voltage-gated sodium channel activity 1/2065 21/18639 0.0476190476190476 0.429816672431685 0.915181783917591 1 GO:0009975 cyclase activity 1/2065 21/18639 0.0476190476190476 0.429816672431685 0.915181783917591 1 GO:0140097 catalytic activity, acting on DNA 30/2065 336/18639 0.0892857142857143 0.805906260809409 0.915628887977408 1 GO:0005004 GPI-linked ephrin receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0005008 hepatocyte growth factor receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0005009 insulin receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0005011 macrophage colony-stimulating factor receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0005020 stem cell factor receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0008288 boss receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0036332 placental growth factor receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0038062 protein tyrosine kinase collagen receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0060175 brain-derived neurotrophic factor receptor activity 3/2065 49/18639 0.0612244897959184 0.552621435983594 0.919847729186418 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/2065 36/18639 0.0555555555555556 0.501452784503632 0.920146667919064 1 GO:0055106 ubiquitin-protein transferase regulator activity 2/2065 36/18639 0.0555555555555556 0.501452784503632 0.920146667919064 1 GO:0003678 DNA helicase activity 5/2065 74/18639 0.0675675675675676 0.609875008180093 0.923814301186392 1 GO:0003684 damaged DNA binding 5/2065 74/18639 0.0675675675675676 0.609875008180093 0.923814301186392 1 GO:0016881 acid-amino acid ligase activity 1/2065 22/18639 0.0454545454545455 0.410279550957517 0.924589325877532 1 GO:0034062 5'-3' RNA polymerase activity 1/2065 22/18639 0.0454545454545455 0.410279550957517 0.924589325877532 1 GO:0070034 telomerase RNA binding 1/2065 22/18639 0.0454545454545455 0.410279550957517 0.924589325877532 1 GO:0097747 RNA polymerase activity 1/2065 22/18639 0.0454545454545455 0.410279550957517 0.924589325877532 1 GO:0005006 epidermal growth factor receptor activity 3/2065 50/18639 0.06 0.541569007263922 0.926255491967512 1 GO:0005007 fibroblast growth factor receptor activity 3/2065 50/18639 0.06 0.541569007263922 0.926255491967512 1 GO:0005017 platelet-derived growth factor receptor activity 3/2065 50/18639 0.06 0.541569007263922 0.926255491967512 1 GO:0005019 platelet-derived growth factor beta-receptor activity 3/2065 50/18639 0.06 0.541569007263922 0.926255491967512 1 GO:0005021 vascular endothelial growth factor receptor activity 3/2065 51/18639 0.0588235294117647 0.530950007121493 0.932189842450501 1 GO:0005030 neurotrophin receptor activity 3/2065 51/18639 0.0588235294117647 0.530950007121493 0.932189842450501 1 GO:0000295 adenine nucleotide transmembrane transporter activity 1/2065 23/18639 0.0434782608695652 0.392441309611538 0.932953887410695 1 GO:0003887 DNA-directed DNA polymerase activity 1/2065 23/18639 0.0434782608695652 0.392441309611538 0.932953887410695 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2065 23/18639 0.0434782608695652 0.392441309611538 0.932953887410695 1 GO:0008171 O-methyltransferase activity 1/2065 23/18639 0.0434782608695652 0.392441309611538 0.932953887410695 1 GO:0016917 GABA receptor activity 1/2065 23/18639 0.0434782608695652 0.392441309611538 0.932953887410695 1 GO:0140103 catalytic activity, acting on a glycoprotein 1/2065 23/18639 0.0434782608695652 0.392441309611538 0.932953887410695 1 GO:0051536 iron-sulfur cluster binding 5/2065 76/18639 0.0657894736842105 0.593825665859564 0.9338287480237 1 GO:0051540 metal cluster binding 5/2065 77/18639 0.0649350649350649 0.586113644225024 0.938380084379048 1 GO:0003727 single-stranded RNA binding 6/2065 89/18639 0.0674157303370786 0.608504502543733 0.938886790455383 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/2065 39/18639 0.0512820512820513 0.462879493387968 0.940063821475598 1 GO:0015149 hexose transmembrane transporter activity 1/2065 24/18639 0.0416666666666667 0.376089588377724 0.940391050200602 1 GO:0055056 D-glucose transmembrane transporter activity 1/2065 24/18639 0.0416666666666667 0.376089588377724 0.940391050200602 1 GO:0008146 sulfotransferase activity 3/2065 53/18639 0.0566037735849057 0.510914157796153 0.942758709541822 1 GO:0140662 ATP-dependent protein folding chaperone 2/2065 40/18639 0.05 0.451307506053269 0.945581812089343 1 GO:0015662 P-type ion transporter activity 1/2065 25/18639 0.04 0.361046004842615 0.947003592845553 1 GO:0017056 structural constituent of nuclear pore 1/2065 25/18639 0.04 0.361046004842615 0.947003592845553 1 GO:0140358 P-type transmembrane transporter activity 1/2065 25/18639 0.04 0.361046004842615 0.947003592845553 1 GO:0017069 snRNA binding 3/2065 54/18639 0.0555555555555556 0.501452784503632 0.947449897441106 1 GO:0016500 protein-hormone receptor activity 4/2065 67/18639 0.0597014925373134 0.538874634093455 0.948069720847137 1 GO:0016757 glycosyltransferase activity 22/2065 267/18639 0.0823970037453183 0.743727725331229 0.948610475643802 1 GO:0015216 purine nucleotide transmembrane transporter activity 1/2065 26/18639 0.0384615384615385 0.347159620040976 0.952882908456057 1 GO:0120014 phospholipid transfer activity 1/2065 26/18639 0.0384615384615385 0.347159620040976 0.952882908456057 1 GO:0008307 structural constituent of muscle 2/2065 42/18639 0.0476190476190476 0.429816672431685 0.955198959783608 1 GO:0016859 cis-trans isomerase activity 2/2065 42/18639 0.0476190476190476 0.429816672431685 0.955198959783608 1 GO:0031492 nucleosomal DNA binding 2/2065 42/18639 0.0476190476190476 0.429816672431685 0.955198959783608 1 GO:0005104 fibroblast growth factor receptor binding 1/2065 27/18639 0.037037037037037 0.334301856335755 0.958110265359203 1 GO:0008266 poly(U) RNA binding 1/2065 27/18639 0.037037037037037 0.334301856335755 0.958110265359203 1 GO:0008320 protein transmembrane transporter activity 1/2065 27/18639 0.037037037037037 0.334301856335755 0.958110265359203 1 GO:0015276 ligand-gated monoatomic ion channel activity 14/2065 186/18639 0.0752688172043011 0.67938764352105 0.958579327952065 1 GO:0016782 transferase activity, transferring sulphur-containing groups 4/2065 70/18639 0.0571428571428571 0.515780006918021 0.95903344210463 1 GO:0005245 voltage-gated calcium channel activity 2/2065 43/18639 0.0465116279069767 0.419820935863506 0.959375142657613 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/2065 43/18639 0.0465116279069767 0.419820935863506 0.959375142657613 1 GO:0008276 protein methyltransferase activity 6/2065 95/18639 0.0631578947368421 0.570072639225182 0.959505675292578 1 GO:0022834 ligand-gated channel activity 14/2065 188/18639 0.074468085106383 0.672160115398485 0.962664476485741 1 GO:0005242 inward rectifier potassium channel activity 1/2065 28/18639 0.0357142857142857 0.322362504323763 0.962757928266641 1 GO:0008527 taste receptor activity 1/2065 28/18639 0.0357142857142857 0.322362504323763 0.962757928266641 1 GO:0016866 intramolecular transferase activity 1/2065 28/18639 0.0357142857142857 0.322362504323763 0.962757928266641 1 GO:0017116 single-stranded DNA helicase activity 3/2065 58/18639 0.0517241379310345 0.466869833848209 0.962855241469328 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/2065 44/18639 0.0454545454545455 0.410279550957517 0.963176430892416 1 GO:0015459 potassium channel regulator activity 3/2065 59/18639 0.0508474576271186 0.458956785816884 0.965980665767881 1 GO:0043236 laminin binding 1/2065 29/18639 0.0344827586206897 0.311246555898806 0.966890155343606 1 GO:0004521 RNA endonuclease activity 4/2065 73/18639 0.0547945205479452 0.494583568277555 0.967819685024437 1 GO:0008187 poly-pyrimidine tract binding 1/2065 30/18639 0.0333333333333333 0.300871670702179 0.970564084909186 1 GO:0015215 nucleotide transmembrane transporter activity 1/2065 30/18639 0.0333333333333333 0.300871670702179 0.970564084909186 1 GO:0031624 ubiquitin conjugating enzyme binding 1/2065 30/18639 0.0333333333333333 0.300871670702179 0.970564084909186 1 GO:0005200 structural constituent of cytoskeleton 7/2065 112/18639 0.0625 0.564134382566586 0.971150381604055 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/2065 48/18639 0.0416666666666667 0.376089588377724 0.975232245244125 1 GO:0070717 poly-purine tract binding 1/2065 32/18639 0.03125 0.282067191283293 0.9767346495161 1 GO:0005261 monoatomic cation channel activity 27/2065 341/18639 0.0791788856304985 0.714680508119546 0.979209697855217 1 GO:0042923 neuropeptide binding 1/2065 33/18639 0.0303030303030303 0.273519700638345 0.979316632036079 1 GO:0019843 rRNA binding 3/2065 65/18639 0.0461538461538462 0.416591544049171 0.980098516222519 1 GO:0005216 monoatomic ion channel activity 37/2065 448/18639 0.0825892857142857 0.745463291248703 0.980614549580568 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/2065 34/18639 0.0294117647058824 0.265475003560746 0.981612190181059 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/2065 34/18639 0.0294117647058824 0.265475003560746 0.981612190181059 1 GO:0034061 DNA polymerase activity 1/2065 35/18639 0.0285714285714286 0.257890003459011 0.983653083880393 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/2065 53/18639 0.0377358490566038 0.340609438530769 0.985022605952913 1 GO:0016860 intramolecular oxidoreductase activity 2/2065 53/18639 0.0377358490566038 0.340609438530769 0.985022605952913 1 GO:0017046 peptide hormone binding 2/2065 53/18639 0.0377358490566038 0.340609438530769 0.985022605952913 1 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/2065 36/18639 0.0277777777777778 0.250726392251816 0.98546755290786 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/2065 36/18639 0.0277777777777778 0.250726392251816 0.98546755290786 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/2065 36/18639 0.0277777777777778 0.250726392251816 0.98546755290786 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/2065 36/18639 0.0277777777777778 0.250726392251816 0.98546755290786 1 GO:0016779 nucleotidyltransferase activity 8/2065 136/18639 0.0588235294117647 0.530950007121493 0.987192412866 1 GO:0008170 N-methyltransferase activity 5/2065 98/18639 0.0510204081632653 0.460517863319662 0.987579585059696 1 GO:0016758 hexosyltransferase activity 13/2065 197/18639 0.065989847715736 0.595634271948477 0.988064740369204 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/2065 73/18639 0.0410958904109589 0.370937676208166 0.990460781223332 1 GO:0001653 peptide receptor activity 7/2065 128/18639 0.0546875 0.493617584745763 0.990794590374952 1 GO:0008227 G protein-coupled amine receptor activity 1/2065 41/18639 0.024390243902439 0.220150002952814 0.99193118788003 1 GO:0003730 mRNA 3'-UTR binding 18/2065 262/18639 0.0687022900763359 0.620117183889988 0.992174946492921 1 GO:0008528 G protein-coupled peptide receptor activity 6/2065 122/18639 0.0491803278688525 0.443909022347477 0.994679864772493 1 GO:0000049 tRNA binding 3/2065 80/18639 0.0375 0.338480629539952 0.995067978111557 1 GO:0005267 potassium channel activity 6/2065 124/18639 0.0483870967741935 0.436749199406389 0.995466342954743 1 GO:0008188 neuropeptide receptor activity 1/2065 48/18639 0.0208333333333333 0.188044794188862 0.996460464319435 1 GO:0140223 general transcription initiation factor activity 2/2065 68/18639 0.0294117647058824 0.265475003560746 0.996810513673811 1 GO:0015079 potassium ion transmembrane transporter activity 8/2065 160/18639 0.05 0.451307506053269 0.997792564765239 1 GO:0022832 voltage-gated channel activity 9/2065 175/18639 0.0514285714285714 0.464202006226219 0.998077164408127 1 GO:0022836 gated channel activity 20/2065 318/18639 0.0628930817610063 0.567682397551281 0.99881161329407 1 GO:0022843 voltage-gated monoatomic cation channel activity 6/2065 143/18639 0.041958041958042 0.378719585499247 0.999058931800768 1 GO:0005249 voltage-gated potassium channel activity 3/2065 98/18639 0.0306122448979592 0.276310717991797 0.999143794497596 1 GO:0005244 voltage-gated monoatomic ion channel activity 8/2065 173/18639 0.046242774566474 0.417394225251578 0.999199681795975 1 GO:0022824 transmitter-gated monoatomic ion channel activity 1/2065 63/18639 0.0158730158730159 0.143272224143895 0.999395196085197 1 GO:0022835 transmitter-gated channel activity 1/2065 63/18639 0.0158730158730159 0.143272224143895 0.999395196085197 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 7/2065 167/18639 0.0419161676646707 0.378341621841064 0.999583712468883 1 GO:0008173 RNA methyltransferase activity 1/2065 67/18639 0.0149253731343284 0.134718658523364 0.999622530603083 1 GO:0030594 neurotransmitter receptor activity 2/2065 97/18639 0.0206185567010309 0.186106188063204 0.999855784214577 1 GO:0140098 catalytic activity, acting on RNA 22/2065 387/18639 0.0568475452196382 0.513114477166507 0.999927879803102 1 GO:0008168 methyltransferase activity 8/2065 204/18639 0.0392156862745098 0.353966671414328 0.999938049712918 1 GO:0016741 transferase activity, transferring one-carbon groups 8/2065 215/18639 0.0372093023255814 0.335856748690805 0.999975982669403 1 GO:0045182 translation regulator activity 10/2065 356/18639 0.0280898876404494 0.253543542726555 0.999999998877142 1 GO:0003735 structural constituent of ribosome 1/2065 175/18639 0.00571428571428571 0.0515780006918021 0.999999998925187 1 GO:0030371 translation repressor activity 7/2065 329/18639 0.0212765957446809 0.19204574725671 0.999999999904957 1 GO:1903231 mRNA base-pairing translational repressor activity 1/2065 298/18639 0.00335570469798658 0.0302890943659912 1 1