category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	85/956	250/9376	3.33456066945607	LAPTM5/CTSD/CD68/CTSS/CTSB/CTSZ/PSAP/NPC2/CD63/LGMN/ASAH1/ACP5/LIPA/CTSL/ATP6V1F/ATP6V0B/CTSH/LITAF/HEXB/PPT1/CTSC/SLC11A1/CTSA/ATP6V0D1/SCARB2/ATP6V0E1/TPP1/AP1S2/VAMP8/SLC15A3/LAMP1/GNS/HEXA/LAMP2/RRAGD/DNASE2/TCIRG1/IDS/DMXL2/MITF/ATP6AP1/M6PR/LAPTM4A/ACP2/ARL8A/SLC17A5/PLA2G15/CLCN7/GAA/ATP6V1G1/IGF2R/FUCA1/VPS13C/ATP6V1B2/GNPTG/TLR7/MANBA/CLN8/CTBS/TPCN1/ATP6V0A1/MCOLN1/GPR155/GGA1/GLA/TLR8/CTSK/GNPTAB/AP2S1/CLN5/CTSO/GALC/ATP6V1A/ROGDI/SLC2A6/GM2A/NAGLU/GALNS/ARSA/NAGPA/GLB1/BLOC1S1/AP1G2/NPC1/NAGA	12.6064694399929
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	64/956	155/9376	4.04956134431097	HLA-DRA/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/CTSS/HLA-DPB1/CYBA/HLA-C/MSR1/ITGB2/HLA-DMA/HLA-DQB1/OLR1/HLA-E/HLA-DQA1/FCGR3A/CTSL/ATP6V1F/ACTB/CD36/ATP6V0B/HLA-DMB/NCF2/HLA-DQA2/HLA-DRB5/CYBB/FCGR1A/ATP6V0D1/TUBA1A/HLA-F/ATP6V0E1/CD14/CORO1A/LAMP1/FCGR2A/CLEC7A/LAMP2/ITGAM/TCIRG1/MARCO/ATP6AP1/M6PR/C3/HLA-DOA/NCF4/TLR4/ATP6V1G1/ATP6V1B2/NCF1/TLR2/FCGR3B/ATP6V0A1/STX7/SCARB1/TLR6/RILP/ITGB1/ATP6V1A/FCGR2B/MRC2/TAP1/TUBB2A/THBS3	12.8994962504896
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	47/956	95/9376	4.85214710416208	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/ITGB2/HLA-DMA/CCL3/HLA-DQB1/ACP5/FOS/HLA-DQA1/CXCL2/JUN/CTSL/ATP6V1F/ATP6V0B/IL1B/HLA-DMB/CXCL3/HLA-DQA2/IL18/TNFSF13B/HLA-DRB5/ATP6V0D1/ATP6V0E1/CCL20/CD86/ICAM1/TCIRG1/CCL2/VEGFA/ATP6AP1/HLA-DOA/TNF/TLR4/ATP6V1G1/ITGAL/ATP6V1B2/TLR2/CCL5/FLT1/ATP6V0A1/CTSK/ATP6V1A/TNFRSF11A/CSF1/IL1A	12.7152767856351
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	42/956	78/9376	5.28097843579015	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/CYBA/NFKBIA/ITGB2/HLA-DMA/HLA-DQB1/FOS/HLA-DQA1/JUN/FCGR3A/IL1B/HLA-DMB/NCF2/HLA-DQA2/HLA-DRB5/CYBB/FCGR1A/FCGR2A/IFNGR2/ITGAM/STAT1/PTPN6/C3/IFNGR1/HLA-DOA/NCF4/TNF/TLR4/PTGS2/NCF1/JAK1/TLR2/IL10/PRKCB/ITGA4/FCGR3B/ITGB1/IL1A/CR1	12.7924612235542
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	64/956	181/9376	3.46785639982431	HLA-DRA/CD74/CTSD/HLA-DPA1/FCER1G/HLA-DRB1/CTSS/HLA-DPB1/ITGB2/HLA-DMA/HLA-DQB1/HLA-DQA1/FCGR3A/LSP1/ATP6V0B/IL1B/HLA-DMB/HLA-DQA2/IL18/HLA-DRB5/ITGAX/FCGR1A/ATP6V0D1/CD14/CORO1A/CEBPB/LAMP1/FCGR2A/CLEC7A/IFNGR2/LAMP2/ITGAM/BID/STAT1/TCIRG1/SYK/ATP6AP1/C3/IFNGR1/HLA-DOA/IL10RA/TNF/PLK3/TLR4/JAK1/TLR2/TLR1/IL10/CIITA/CAMK2D/SPHK1/RHOA/FCGR3B/ATP6V0A1/VDR/CARD9/TLR6/RIPK2/FCGR2B/MRC2/IL1A/CLEC4E/CR1/CREB1	11.2964463612648
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	53/956	142/9376	3.66055748718251	TYROBP/CYBA/TREM2/NFKBIA/ACP5/FOS/JUNB/JUN/FCGR3A/IL1B/NCF2/FOSB/SPI1/LILRB4/JUND/FCGR1A/FCGR2A/IFNGR2/SQSTM1/CSF1R/OSCAR/SIRPA/LCP2/STAT1/SOCS3/TGFBR1/SYK/MITF/BTK/IFNGR1/NCF4/TNF/TGFBR2/LILRB1/LILRB2/NCF1/JAK1/LILRA2/LILRB3/SIRPB1/STAT2/FCGR3B/CYLD/ITPR1/RELB/CTSK/TNFRSF11A/FCGR2B/CSF1/LILRA6/NFKB2/IL1A/CREB1	10.7641668993886
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	34/956	82/9376	4.06653740177569	HLA-DRA/CD74/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/CTSS/HLA-DPB1/CTSB/HSPA1A/HLA-C/B2M/LGMN/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/CTSL/HSPA1B/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/CD4/IFI30/TAPBP/HLA-DOA/HSPA6/TNF/CIITA/TAPBPL/TAP1/PSME2/CREB1	9.39750134932968
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	36/956	100/9376	3.53071129707113	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/CD9/HLA-DMA/HLA-DQB1/HLA-DQA1/CD44/CD36/CD37/IL1B/HLA-DMB/HLA-DQA2/HLA-DRB5/FCGR1A/CD4/CD14/CSF1R/ITGAM/IL6R/HLA-DOA/TNF/CD33/CD59/ANPEP/IL7R/ITGA4/CD22/CD1D/CSF1/IL1A/CD38/CR1/CSF3R/IL4R	8.57276210897607
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	28/956	66/9376	4.16077088880436	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/JUN/IL1B/HLA-DMB/HLA-DQA2/IL18/HLA-DRB5/IFNGR2/STAT1/IFNGR1/MAF/HLA-DOA/IL2RG/TNF/TLR4/TLR2/IL10/STAT6/STAT3/TLR5/IL1A/IL4R	8.68257778312372
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	54/956	205/9376	2.58344729053985	HLA-DRA/HLA-B/VIM/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/B2M/NFKBIA/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/JUN/CD44/HLA-DMB/GADD45B/HLA-DQA2/HLA-DRB5/TNFAIP3/HLA-F/TAPBP/ICAM1/BID/STAT1/LYN/CDKN1A/SYK/CD58/BTK/HLA-DOA/TNF/NFKBIE/CD40/ITGAL/JAK1/TLR2/OAS2/CXCL10/OAS1/ISG15/STAT2/ENTPD1/RB1/STAT3/TAPBPL/RELB/CCND2/RUNX3/TAP1/HES1/NFKB2/CCND1	7.72379491361748
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	36/956	109/9376	3.23918467621205	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/NFKBIA/HLA-DMA/HLA-DQB1/FOS/HLA-DQA1/JUN/IL1B/HLA-DMB/HLA-DQA2/HLA-DRB5/CD4/IFNGR2/STAT1/IL6R/TGFBR1/AHR/IFNGR1/HLA-DOA/EBI3/IL2RG/TGFBR2/NFKBIE/STAT5A/JAK1/STAT6/IL6ST/RUNX1/STAT3/HIF1A/LAT/IL27RA/IL4R	7.92304494286791
Human Diseases	Immune disease	hsa05330	Allograft rejection	20/956	39/9376	5.0295032721811	HLA-DRA/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/CD86/HLA-DOA/TNF/CD40/IL10	8.49647287918228
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	48/956	180/9376	2.61534170153417	HLA-DRA/CD74/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/B2M/NFKBIA/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/BST2/IL1B/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/PILRA/TNFRSF14/IFNGR2/TAPBP/BID/STAT1/SOCS3/SYK/CCL2/BIRC3/C3/IFNGR1/HLA-DOA/TNF/POU2F2/JAK1/TLR2/CCL5/OAS2/OAS1/SP100/STAT2/CARD9/TNFSF14/TAPBPL/TAP1/IFIH1/TSC1	7.37326282275245
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	21/956	44/9376	4.68086724990491	HLA-DRA/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/IL1B/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/CD86/HLA-DOA/TNF/IL1A/PTPRN2	8.24608233327126
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	27/956	70/9376	3.78290496114764	HLA-DRA/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/ITGB2/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/ACTB/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/CD86/ICAM1/RAC2/BID/HLA-DOA/ABL2/CD40/ITGAL/SNTB1/CCND1	7.87452578660506
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	33/956	99/9376	3.26917712691771	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/ITGB2/HLA-DMA/HLA-DQB1/HLA-DQA1/FCGR3A/C1QB/C1QA/HLA-DMB/C5AR1/C1QC/HLA-DQA2/HLA-DRB5/FPR3/FCGR1A/C3AR1/FCGR2A/ICAM1/ITGAM/C2/CFD/C3/PTAFR/HLA-DOA/FPR1/ITGAL/SELPLG/IL10/FCGR3B/FCGR2B	7.64787453893734
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	40/956	138/9376	2.84276271905888	FN1/NFKBIA/FOS/JUN/ACTB/IL1B/IL18/CD4/FCGR2A/PYCARD/ARPC3/ARPC1B/RAC2/LCP2/SKAP2/CASP1/WAS/CCL2/TNF/TLR4/ACTR2/WIPF1/VAV1/IL10/ARPC4/RPS6KA1/ACTR3/ITGA4/RHOA/PKN2/RPS6KA2/GIT2/RHOG/NLRP3/NLRC4/LAT/ITGB1/RPS6KA3/WIPF3/LIMK1	7.34815858137471
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	35/956	112/9376	3.06485355648536	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HSPA1A/NFKBIA/HLA-DMA/HLA-DQB1/HLA-DQA1/HSPA1B/HLA-DMB/LY96/GNAI2/HLA-DQA2/HLA-DRB5/IFNGR2/ALOX5/STAT1/BIRC3/IFNGR1/HLA-DOA/IL10RA/HSPA6/TNF/TLR4/CD40/JAK1/PIK3R5/TLR2/PPIF/IL10/CIITA/STAT3/ITGB1/CCR5	7.40725904197694
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	23/956	56/9376	4.02809324566647	HSPA1A/NFKBIA/ITGB2/CXCL2/HSPA1B/IL1B/CXCL3/IL18/CD14/PYCARD/ITGAM/CASP1/C3/HSPA6/TNF/TLR4/TLR2/NAIP/TLR5/NLRC4/CLK1/NFKB2/CR1	7.65797316928116
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	45/956	173/9376	2.55109197765255	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/NFKBIA/HLA-DMA/HLA-DQB1/HLA-DQA1/ACTB/IL1B/HLA-DMB/DNAJB1/HLA-DQA2/IL18/HLA-DRB5/PYCARD/IFNGR2/TNFSF10/ICAM1/BID/STAT1/CASP1/SOCS3/CCL2/IFNGR1/HLA-DOA/TNF/MX2/TLR4/JAK1/CCL5/OAS2/CXCL10/TLR7/CIITA/MX1/OAS1/PRKCB/STAT2/NLRP3/KPNA6/IFIH1/IL1A/TNFRSF10A/KPNA1	6.93832167538264
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	47/956	187/9376	2.46499451815721	CTSB/CYBA/NFKBIA/TXNIP/CXCL2/JUN/IL1B/CXCL3/IL18/GPSM3/CYBB/TNFAIP3/IFI16/NAMPT/PYCARD/CARD16/STAT1/CASP1/CCL2/BIRC3/GABARAPL1/TRPV2/MAP1LC3B/TNF/TLR4/P2RX7/JAK1/GABARAP/PLCB2/CCL5/OAS2/GBP4/PSTPIP1/GBP5/OAS1/NAIP/RHOA/STAT2/PKN2/CARD9/NLRP3/ITPR1/CARD6/NLRC4/RIPK2/GABARAPL2/GBP3	6.81838022235629
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	20/956	45/9376	4.35890283589028	HLA-DRA/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/IL1B/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/CD86/HLA-DOA/TNF/IL1A	7.6102362974734
Human Diseases	Immune disease	hsa05310	Asthma	16/956	32/9376	4.90376569037657	HLA-DRA/HLA-DPA1/FCER1G/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/PRG2/HLA-DQA2/HLA-DRB5/HLA-DOA/TNF/CD40/IL10	7.45333867357199
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	29/956	93/9376	3.05826247356818	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/NFKBIA/HLA-DMA/HLA-DQB1/FOS/HLA-DQA1/JUN/HLA-DMB/HLA-DQA2/HLA-DRB5/CD4/IFNGR2/STAT1/IFNGR1/MAF/HLA-DOA/NOTCH2/IL2RG/NFKBIE/STAT5A/JAK1/STAT6/LAT/RUNX3/MAML1/IL4R	6.72135128004133
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	26/956	78/9376	3.26917712691771	ITGB2/FOS/JUN/C1QB/C1QA/IL1B/LY96/GNAI2/C1QC/CD14/PYCARD/ITGAM/C2/CASP1/IRF8/C3/TNF/TLR4/IL10/SERPING1/CFL1/IRF1/RHOA/NLRP3/ITGB1/IL1A	6.78077706787445
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	49/956	216/9376	2.224856655819	HSPA1A/CYBA/NFKBIA/CCL3/FOS/OLR1/SOD2/CXCL2/JUN/CD36/HSPA1B/IL1B/NCF2/CXCL3/LY96/IL18/CYBB/ABCA1/MMP9/CD14/PYCARD/TNFSF10/ICAM1/BID/CASP1/LYN/CCL2/NCF4/HSPA6/TNF/NFE2L2/TLR4/POU2F2/CD40/NCF1/ABCG1/VAV1/TLR2/PLCB2/CCL5/CAMK2D/RHOA/STAT3/MAP3K5/NLRP3/ITPR1/TLR6/ERN1/TNFRSF10A	6.1365311598224
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	40/956	160/9376	2.45188284518828	HLA-DRA/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/ITGB2/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/HLA-DMB/PTPRC/ALCAM/HLA-DQA2/HLA-DRB5/HLA-F/CD4/CD86/SDC2/ICAM1/ITGAM/CD99/CD58/HLA-DOA/SIGLEC1/SPN/CD40/ITGAL/SELPLG/CADM1/CLDN19/ITGA4/ICAM2/F11R/CD22/SDC3/ITGB1/ESAM	6.2413547893362
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	50/956	224/9376	2.18918111177525	HLA-DRA/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/B2M/NFKBIA/TSPO/ITGB2/HLA-DMA/HLA-DQB1/FOS/HLA-E/ZFP36/HLA-DQA1/JUN/HLA-DMB/SPI1/HLA-DQA2/HLA-DRB5/HLA-F/CD4/EGR1/ICAM1/TGFBR1/CDKN1A/MMP7/HLA-DOA/IL2RG/TNF/ADCY7/TGFBR2/STAT5A/CD40/ITGAL/JAK1/CREB5/PRKACB/NRP1/RB1/RELB/CCND2/EGR2/TLN1/NFKB2/CCND1/ETS2/CREB1	6.06977432920265
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	28/956	98/9376	2.80215182307232	MARCKS/FCGR3A/GSN/PTPRC/FCGR1A/FCGR2A/ARPC3/ARPC1B/RAC2/LYN/HCK/SYK/WAS/ACTR2/NCF1/VAV1/CFL1/ARPC4/PRKCB/ACTR3/SPHK1/FCGR3B/PLA2G4C/INPP5D/LAT/FCGR2B/PLD1/LIMK1	6.04276587334282
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	44/956	196/9376	2.20169071812826	HLA-B/HLA-A/HLA-C/NFKBIA/FOS/HLA-E/ZFP36/CXCL2/JUN/CXCL3/CLEC2B/HLA-F/CD86/ICAM1/UBC/BID/STAT1/LYN/CDKN1A/HCK/SYK/VEGFA/C3/IFNGR1/MAP1LC3B/PREX1/PTGS2/JAK1/PIK3R5/IL6ST/STAT2/GNGT2/RB1/STAT3/ITPR1/HIF1A/CCR1/CCR5/CCND1/MICB/MICA/TCF7L1/ATG3/CREB1	5.72872454291255
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	29/956	105/9376	2.70874676230325	FCER1G/NFKBIA/JUN/LSP1/IL1B/PYCARD/CLEC7A/STAT1/CASP1/SYK/TNF/PLK3/PTGS2/RRAS/IL10/IRF1/RHOA/STAT2/BCL3/MRAS/CARD9/CYLD/NLRP3/ITPR1/RELB/EGR2/NFKB2/CLEC4E/CBLB	5.93290784108222
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	28/956	100/9376	2.74610878661088	CCL3/CXCL2/CXCL3/CXCR4/CCL4/IL18/CCL20/CCL18/TNFRSF14/TNFSF10/CSF1R/TNFRSF1B/IL6R/CCL2/IL10RA/IL2RG/TNF/CCL7/CXCL9/IL10/CCL5/CXCL10/IL6ST/TNFSF14/CCR1/CSF1/CCR5/TNFRSF10A	5.91492805257241
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	31/956	119/9376	2.55490313280124	NFKBIA/FOS/JUNB/CXCL2/JUN/IL1B/CXCL3/TNFAIP3/MMP9/CCL20/CEBPB/ICAM1/TNFRSF1B/SOCS3/CCL2/BIRC3/TNF/PTGS2/CCL5/CXCL10/RHBDF2/IRF1/CREB5/BCL3/MAP3K5/CFLAR/CYLD/CSF1/MLKL/ADAM17/CREB1	5.75175297762645
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/956	54/9376	3.45079807841314	HLA-DRA/HLA-B/HLA-DPA1/HLA-A/HLA-DRB1/HLA-DPB1/HLA-C/HLA-DMA/HLA-DQB1/HLA-E/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-DRB5/HLA-F/CD86/HLA-DOA/CD40/IL10	6.08567002281089
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	26/956	91/9376	2.80215182307232	CD81/NFKBIA/FOS/JUN/LILRB4/RAC2/PTPN6/LYN/SYK/PIK3AP1/BTK/RASGRP3/CD72/NFKBIE/LILRB1/DAPP1/LILRB2/VAV1/LILRA2/LILRB3/PRKCB/IFITM1/INPP5D/CD22/FCGR2B/LILRA6	5.82075950788905
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	37/956	157/9376	2.31132905151507	LIPA/C1QB/C1QA/CD36/DUSP2/SGK1/C1QC/HAVCR2/ABCA1/CEBPB/ALOX5/SIRPA/LRP1/CASP1/PTPN6/PTGER4/PLA2G15/AXL/MERTK/PTGS2/NR1H3/IL10/CAMK2D/SIRPB1/TMEM30A/SPHK1/SIGLEC10/GPR132/STAB1/ADAM9/HIF1A/PTGER2/ADAM10/ADAM17/CPT1A/ATP11C/CREB1	5.58313513997463
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	18/956	50/9376	3.53071129707113	CD81/ITGB2/CD36/IL1B/IL18/SDC2/ICAM1/LRP1/CCL2/TNF/TLR4/HGF/CD40/ITGAL/TLR2/IL10/THBS3/CR1	6.04558649381426
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	28/956	105/9376	2.61534170153417	NFKBIA/BCL2A1/CXCL2/IL1B/GADD45B/CXCL3/LY96/CCL4/TNFSF13B/TNFAIP3/CD14/ICAM1/LYN/SYK/BIRC3/BTK/TNF/TLR4/PTGS2/CD40/PRKCB/TNFSF14/CFLAR/CYLD/RELB/LAT/TNFRSF11A/NFKB2	5.60859786744595
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/956	248/9376	1.97732487515184	NFKBIA/FOS/JUN/ACTB/S100A10/IL1B/LY96/PTPRC/IL18/TUBA1A/CD14/FLNA/PYCARD/NCKAP1L/ARPC3/TNFSF10/ARPC1B/RHOB/CASP1/ANXA2/BIRC3/M6PR/TNF/ARL8A/CYTH4/TLR4/AHNAK/CYTH1/RRAS/ACTR2/TLR2/ARPC4/STX10/ACTR3/NAIP/RHOA/PLEKHM2/TLR5/RHOG/GCC2/NLRP3/NLRC4/TLR6/RIPK2/RILP/TUBB2A/MLKL/TCF7L1/TNFRSF10A/KPNA1	5.25575988737543
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	29/956	115/9376	2.47320356558123	FOS/SGK1/MAFB/NR4A2/GNAI2/JUND/ARRB2/EGR1/HBEGF/CDKN1A/ADCY7/AKAP13/MEF2A/GNA13/MEF2C/PLCB2/PRKCB/RHOA/CREB5/PRKACB/VDR/OXSR1/PDE4B/ITPR1/PDE4A/RUNX2/PLD1/STK39/CREB1	5.35600875158805
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	21/956	71/9376	2.90081914078614	NFKBIA/CXCL2/JUN/ATP6V1F/ATP6V0B/CXCL3/ATP6V0D1/ATP6V0E1/TCIRG1/HBEGF/LYN/ATP6AP1/ATP6V1G1/ATP6V1B2/CCL5/ATP6V0A1/F11R/CSK/ATP6V1A/ADAM10/ADAM17	5.41714325785603
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	17/956	50/9376	3.33456066945607	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/HLA-DMB/CXCR4/HLA-DQA2/TNFSF13B/HLA-DRB5/CD86/HLA-DOA/CD40/IL10/ITGA4	5.57700456333676
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	31/956	133/9376	2.28596596092742	TYROBP/HLA-B/HLA-A/FCER1G/HLA-C/ITGB2/HLA-E/FCGR3A/HCST/CD48/IFNGR2/TNFSF10/ICAM1/RAC2/LCP2/BID/PTPN6/SYK/LAT2/SH3BP2/IFNGR1/TNF/ITGAL/VAV1/PRKCB/FCGR3B/ICAM2/LAT/MICB/MICA/TNFRSF10A	5.03277315534039
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	45/956	227/9376	1.94422428252816	HLA-B/HLA-A/HLA-C/B2M/NFKBIA/CCL3/HLA-E/IL1B/CXCR4/CCL4/GNAI2/HLA-F/TAPBP/RAC2/BID/IL6R/CDKN1A/PTGER4/CCL2/VEGFA/IL10RA/TNF/ADCY7/AKAP13/PTGS2/GNA13/JAK1/PLCB2/CCL5/PRKCB/RHOA/CREB5/PRKACB/GNGT2/RB1/STAT3/TAPBPL/ITPR1/CCR1/TAP1/PTGER2/CCR5/CCND1/TSC1/CREB1	4.85243602522942
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	17/956	52/9376	3.20630833601545	APOE/APOC1/NPC2/TSPO/LIPA/CD36/LPL/CYP27A1/ABCA1/PLTP/NCEH1/LRP1/SOAT1/APOC2/SCARB1/STARD3NL/NPC1	5.37557943542515
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	27/956	109/9376	2.42938850715903	SPP1/NFKBIA/CCL3/FOS/JUN/IL1B/LY96/CCL4/CD14/CD86/STAT1/TNF/TLR4/IRF5/CD40/CXCL9/JAK1/TLR2/TLR1/CCL5/CXCL10/TLR7/STAT2/TLR5/TLR8/TLR6/CTSK	5.05769332174879
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	41/956	201/9376	2.00054122691979	BCL2A1/HPGD/GADD45B/SPI1/FCGR1A/MMP9/CD14/CD86/CEBPB/NR4A3/CSF1R/ID2/NFKBIZ/NUPR1/ITGAM/CDKN1A/BIRC3/MITF/MAF/REL/LYL1/PBX3/BMP2K/IGFBP3/TGFBR2/MEF2C/CD40/JMJD1C/FLI1/FLT1/PTCRA/BCL6/RUNX1/HHEX/CCNT1/CCND2/AFF1/RUNX2/ETV6/CDK14/LMO2	4.83157270470333
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	23/956	88/9376	2.56333206542412	PLAUR/ITGB2/C1QB/C1QA/C5AR1/SERPINA1/C1QC/SERPINE1/A2M/SERPINE2/ITGAX/C3AR1/ITGAM/VSIG4/C2/CFD/C3/CD59/SERPING1/THBD/CR1/VTN/PROC	4.96466566388907
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	54/956	298/9376	1.77720367302238	CSH1/CCL3/CXCL2/IL1B/CXCL3/CXCL16/CXCR4/CCL4/IL1RN/IL18/TNFSF13B/CSH2/CD4/CCL20/CCL18/TNFRSF14/IFNGR2/TNFSF10/CSF1R/TNFSF12/OSM/TNFRSF1B/IL6R/TGFBR1/CCL2/IFNGR1/EBI3/IL10RA/IL2RG/TNF/CCL7/TGFBR2/CD40/CXCL9/IL13RA1/IL10/CCL5/CXCL10/IL7R/IL6ST/GDF15/CSF2RB/TNFSF14/CCR1/TNFRSF11A/IL27RA/CSF1/CCR5/IL1A/RELT/TNFRSF10A/IL17RA/CSF3R/IL4R	4.59416327495901
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	25/956	101/9376	2.42760677741414	FN1/JUN/IL1B/SERPINE1/CYBB/EGR1/ICAM1/STAT1/TGFBR1/CCL2/VEGFA/COL3A1/TNF/TGFBR2/STAT5A/PLCB2/PRKCB/STAT3/PIM1/THBD/DIAPH1/IL1A/CCND1/COL1A2/VEGFB	4.86038718799304
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	40/956	200/9376	1.96150627615063	NFKBIA/FOS/JUN/ACTB/IL1B/IL18/TUBA1A/FCGR2A/PYCARD/NCKAP1L/ARPC3/TNFSF10/ARPC1B/CASP1/PTPN6/MYO1F/MYO5A/TNF/CYTH4/TLR4/CYTH1/GNA13/ACTR2/WIPF1/ARPC4/CLDN19/ACTR3/NAIP/RHOA/TMBIM6/TLR5/NLRP3/MYO1G/ITGB1/ARHGEF2/WIPF3/TUBB2A/LPAR5/PAK2/TNFRSF10A	4.63125780652087
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	25/956	103/9376	2.3804687817362	NFKBIA/CCL3/FOS/JUN/C1QB/C1QA/IL1B/GNAI2/C1QC/SERPINE1/IFNGR2/TGFBR1/CCL2/C3/IFNGR1/TNF/TLR4/GNA15/TGFBR2/TLR2/PLCB2/IL10/CCL5/CFLAR/TLR6	4.74671996311486
Human Diseases	Infectious disease: viral	hsa05162	Measles	30/956	136/9376	2.16342603987202	HSPA1A/NFKBIA/FOS/JUN/HSPA1B/IL1B/TNFAIP3/MSN/BID/STAT1/HSPA6/IL2RG/MX2/TLR4/STAT5A/JAK1/TLR2/OAS2/TLR7/MX1/OAS1/STAT2/STAT3/CCND2/FCGR2B/IFIH1/IL1A/CCND1/CBLB/BBC3	4.60501222157211
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	20/956	76/9376	2.58092931072451	FABP5/OLR1/CD36/LPL/CYP27A1/PLIN2/PLTP/UBC/GK/FABP4/ACSL1/FABP3/NR1H3/ACSL3/SLC27A1/SCD/ME1/ME3/CPT1A/ACSL5	4.66268752676046
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	39/956	204/9376	1.87496923455575	FN1/CD63/PLAUR/CD44/TIMP3/CTSL/ACTB/MMP9/MSN/FLNA/SDC2/HBEGF/PTPN6/IGF2/CDKN1A/VEGFA/TNF/TLR4/HGF/RRAS/VAV1/TLR2/CAMK2D/PRKCB/RHOA/PRKACB/MRAS/HPSE/DCN/STAT3/PPP1R12A/ITPR1/HIF1A/ITGB1/GPC3/LUM/CCND1/COL1A2/VTN	4.25730124731748
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	16/956	55/9376	2.85310003803728	PSAP/ASAH1/HEXB/HEXA/ACER3/CERS6/SGMS2/SPHK1/UGCG/GLA/GALC/GM2A/SGPL1/ARSA/GLB1/CERK	4.6441634298376
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/956	142/9376	2.0720136719901	DUSP1/CYBA/FOS/JUN/CTSL/ACTB/IL1B/NCF2/MMP9/KLF2/SDC2/ICAM1/SQSTM1/HMOX1/RAC2/CCL2/VEGFA/MGST1/TNF/NFE2L2/MEF2A/MEF2C/NCF1/GSTO1/MGST2/RHOA/MAP3K5/THBD/ARHGEF2/IL1A	4.33718652550066
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	37/956	193/9376	1.88020031651744	NFKBIA/CCL3/CXCL2/CXCL3/CXCL16/CXCR4/CCL4/GNAI2/CCL20/CCL18/ARRB2/RAC2/STAT1/DOCK2/LYN/FGR/HCK/WAS/CCL2/ADCY7/CCL7/PREX1/CXCL9/NCF1/VAV1/PIK3R5/PLCB2/CCL5/CXCL10/PRKCB/RHOA/STAT2/PRKACB/GNGT2/STAT3/CCR1/CCR5	4.1631918177731
NA	NA	hsa04518	Integrin signaling	31/956	154/9376	1.97424332989187	SPP1/FN1/ITGB2/ACTB/FERMT3/ITGAX/FLNA/LIMS1/ICAM1/ITGAM/PARVG/RAC2/VEGFA/C3/FBN1/HGF/ITGAL/PARVB/ITGA4/FLT1/ICAM2/CCND2/ITGB1/ARHGEF6/TLN1/CCND1/COL1A2/THBS3/PDGFC/VTN/VEGFB	4.10746414591737
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	51/956	300/9376	1.66728033472803	DUSP1/HSPA1A/FOS/JUN/HSPA1B/IL1B/DUSP2/GADD45B/HSPB1/JUND/CD14/EREG/ARRB2/FLNA/CSF1R/MAP3K2/RAC2/IGF2/TGFBR1/VEGFA/RASGRP3/MAPKAPK3/NR4A1/HSPA6/TNF/DUSP10/HGF/TGFBR2/RRAS/MEF2C/AREG/PRKCB/RPS6KA1/PTPN7/FLT1/CACNA2D4/TAOK3/PRKACB/MRAS/MAP3K5/RPS6KA2/PLA2G4C/RELB/RPS6KA3/CSF1/MAPKAPK5/NFKB2/IL1A/PAK2/PDGFC/VEGFB	3.9580406334574
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	25/956	116/9376	2.11369210792093	CYBA/ITGB2/ACTB/NCF2/CXCR4/GNAI2/CYBB/MMP9/MSN/ICAM1/ITGAM/CD99/RAC2/NCF4/ITGAL/NCF1/VAV1/PRKCB/CLDN19/ITGA4/RHOA/RASSF5/F11R/ITGB1/ESAM	4.06674725261579
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	28/956	137/9376	2.00445896832911	CTSD/CTSS/CTSB/CTSZ/NFKBIA/FOS/BCL2A1/JUN/CTSL/ACTB/GADD45B/CTSH/CTSC/TUBA1A/TNFSF10/BID/MCL1/BIRC3/TNF/MAP3K5/CSF2RB/CFLAR/ITPR1/CTSK/CTSO/ERN1/TNFRSF10A/BBC3	3.9906031344269
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	8/956	19/9376	4.12948689715922	HEXB/GNS/HEXA/IDS/HPSE/NAGLU/GALNS/GLB1	4.60087211510816
Organismal Systems	Immune system	hsa04611	Platelet activation	26/956	126/9376	2.02377631666335	FCER1G/ACTB/GNAI2/FERMT3/VAMP8/FCGR2A/APBB1IP/LCP2/LYN/TBXAS1/SYK/COL3A1/BTK/ADCY7/PTGS1/GNA13/PIK3R5/PLCB2/RHOA/PRKACB/PLA2G4C/PPP1R12A/ITPR1/ITGB1/TLN1/COL1A2	3.8983248239768
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	32/956	168/9376	1.86810121538155	FTL/FTH1/GLUL/IL1B/CYBB/TNFAIP3/PYCARD/IFNGR2/TNFSF10/CHMP1B/SQSTM1/BID/STAT1/CASP1/BIRC3/IFNGR1/TNF/TLR4/STAT5A/JAK1/CAMK2D/STAT6/STAT2/STAT3/PLA2G4C/CFLAR/CYLD/NLRP3/CHMP1A/MLKL/IL1A/TNFRSF10A	3.82561171235314
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	43/956	250/9376	1.68689539748954	HLA-B/HLA-A/HSPA1A/HLA-C/HLA-E/HSPA1B/CXCR4/HLA-F/ARRB2/ARPC3/CHMP1B/ARPC1B/DAB2/TGFBR1/HSPA6/ARAP1/IL2RG/CYTH4/CYTH1/IGF2R/TGFBR2/ACTR2/WIPF1/SH3KBP1/ARPC4/ACTR3/RHOA/GIT2/ARFGAP3/AP2S1/AGAP3/FOLR3/WIPF3/CHMP1A/ARAP2/CCR5/FOLR2/RAB11FIP2/RAB10/PLD1/EHD4/CBLB/USP8	3.70918860675454
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	21/956	94/9376	2.19104424463634	NFKBIA/S100A9/FOS/CXCL2/JUN/IL1B/FOSB/CXCL3/S100A8/TNFAIP3/JUND/MMP9/CCL20/CEBPB/CCL2/TNF/CCL7/PTGS2/CXCL10/MAPK6/IL17RA	3.910475580309
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	37/956	214/9376	1.69569467798068	HLA-B/HLA-A/HLA-C/B2M/NFKBIA/FOS/HLA-E/JUN/BST2/CXCR4/GNAI2/SAMHD1/HLA-F/CD4/AP1S2/TAPBP/RAC2/BID/TNFRSF1B/TNF/APOBEC3C/TLR4/TLR2/CFL1/PRKCB/GNGT2/APOBEC3G/APOBEC3A/TAPBPL/ITPR1/CUL4B/TAP1/CCR5/CUL5/LIMK1/PAK2/AP1G2	3.468877493277
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	40/956	238/9376	1.64832460180725	NFKBIA/FOS/JUN/C1QB/C1QA/IL1B/C5AR1/C1QC/CYBB/C3AR1/FCGR2A/STAT1/C2/HBEGF/CASP1/IL6R/SYK/CCL2/CFD/C3/TNF/MX2/TLR4/JAK1/TLR2/OAS2/CXCL10/TLR7/MX1/OAS1/PRKCB/ISG15/IL6ST/STAT2/NRP1/STAT3/NLRP3/TLR8/ADAM17/IFIH1	3.41361031547587
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/956	28/9376	3.15242080095637	ATP6V1F/ATP6V0D1/ATP6V0E1/TCIRG1/ATP6V1G1/ATP6V1B2/ATP6V0A1/ATP6V1A/SLC12A7	3.84330970703022
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	16/956	70/9376	2.24172145845786	NFKBIA/CD36/TNFRSF1B/SOCS3/ACSL1/TNF/NFKBIE/PRKAG2/ACSL3/STAT3/G6PC3/ADIPOR1/AGRP/POMC/CPT1A/ACSL5	3.51358302957459
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	51/956	333/9376	1.50205435561084	SPP1/HLA-B/HLA-A/FN1/HLA-C/HLA-E/ATP6V1F/ATP6V0B/ATP6V0D1/HLA-F/ATP6V0E1/STAT1/TCIRG1/CDKN1A/PTGER4/VEGFA/ATP6AP1/NOTCH2/TNF/MX2/PTGS2/ATP6V1G1/LFNG/BCAP31/ATP6V1B2/JAK1/MX1/IRF1/MFNG/ISG15/OASL/ITGA4/STAT2/CREB5/ATP6V0A1/PRKACB/RB1/UBR4/CCND2/ITGB1/ATP6V1A/MAML1/HES1/UBE3A/CCND1/TCF7L1/COL1A2/THBS3/VTN/TSC1/CREB1	3.1432225325559
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/956	42/9376	2.56863917114963	SAT1/FTL/FTH1/CYBB/HMOX1/PRNP/ACSL1/MAP1LC3B/ACSL3/GPX4/ACSL5	3.43298844202714
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	37/956	227/9376	1.59858441007871	CYBA/MT-ND2/MT-ND4/MT-ND1/MT-ND3/NFKBIA/MT-ATP6/MT-CO1/MT-CYB/FOS/MT-CO2/SOD2/MT-ND5/MT-CO3/JUN/NCF2/MT-ND4L/HMOX1/AHR/VEGFA/MGST1/NFE2L2/ABL2/HGF/AKR1A1/NCF1/PPIF/GSTO1/MGST2/MAP3K5/CYP1B1/HIF1A/PTPRJ/MT-ATP8/PTPN1/PLD1/CAT	3.07616803481222
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	29/956	168/9376	1.69296672643953	CSH1/CSH2/IFNGR2/OSM/STAT1/MCL1/PTPN6/SOCS3/IL6R/CDKN1A/IFNGR1/IL10RA/IL2RG/STAT5A/JAK1/IL13RA1/IL10/IL7R/STAT6/IL6ST/STAT2/STAT3/CSF2RB/PIM1/CCND2/IL27RA/CCND1/CSF3R/IL4R	3.05381628082723
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	27/956	154/9376	1.71950225506711	FOS/JUN/ACTB/GNAI2/RGS2/MYL6/CDKN1A/CAMK1/ADCY7/PTGS2/PRKAG2/MEF2C/CAMK1D/PIK3R5/PLCB2/CAMK2D/PRKCB/RHOA/CACNA2D4/PRKACB/KCNJ2/PLA2G4C/PPP1R12A/ITPR1/CCND1/CD38/KCNJ5	3.03346158492341
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/956	133/9376	1.76978009878252	SOD2/SGK1/GADD45B/KLF2/TNFSF10/HOMER3/TGFBR1/CDKN1A/GABARAPL1/PLK3/TGFBR2/PRKAG2/SGK3/GABARAP/IL10/IL7R/S1PR4/BCL6/STAT3/G6PC3/GABARAPL2/CCND2/CCND1/CAT	3.01262143352066
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/956	51/9376	2.30765444253015	ATP6V1F/ACTB/ATP6V0B/ATP6V0D1/ATP6V0E1/TCIRG1/ATP6AP1/ATP6V1G1/ATP6V1B2/ATP6V0A1/PRKACB/ATP6V1A	3.15509325340715
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	32/956	195/9376	1.60944104709795	CYBA/ITGB2/FCGR3A/ACTB/NCF2/C5AR1/CYBB/FPR3/FCGR1A/FCGR2A/CLEC7A/AQP9/ITGAM/RAC2/CASP1/SYK/C3/NCF4/FPR1/TLR4/SIGLEC9/ITGAL/NCF1/SELPLG/TLR2/PPIF/PLCB2/TLR7/PRKCB/FCGR3B/TLR8/CR1	2.89776092635825
NA	NA	hsa04517	IgSF CAM signaling	45/956	299/9376	1.4760498733575	ITGB2/ACTB/CD84/CD48/ITGAX/TUBA1A/MSN/CD86/ARPC3/ICAM1/MYL6/ARPC1B/MBP/ITGAM/LCP2/PTPN6/LYN/DOK2/PMP22/SLAMF7/ITGAL/ACTR2/DOK1/VAV1/EPB41L2/CADM1/GLDN/ARPC4/NRP2/PRKCB/ACTR3/CRTAM/ITGA4/RHOA/ICAM2/F11R/NRP1/CSK/INPP5D/ITGB1/TUBB2A/ESAM/PAK2/LRFN4/PLXNA2	2.81887241029237
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	28/956	169/9376	1.62491644178159	CTSD/CTSB/CTSL/VAMP8/LAMP1/SQSTM1/LAMP2/RRAGD/UBC/GABARAPL1/MAP1LC3B/RRAS/GABARAP/PRKACB/MRAS/STX7/CFLAR/ITPR1/HIF1A/GABARAPL2/SUPT20H/C9orf72/ATG16L2/ERN1/ATG3/TP53INP2/TSC1/DDIT4	2.76226137441747
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/956	103/9376	1.80915627411951	FN1/ITGB2/CXCL2/IL1B/CXCL3/HSPB1/CD14/ITGAM/COL3A1/TNF/TLR4/GNA15/TLR2/PLCB2/IL10/PRKCB/PRKACB/CD1D/COL1A2	2.78227098682532
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	17/956	90/9376	1.85253370525337	NFKBIA/FOS/JUN/CD4/IFNGR2/STAT1/PTPN6/IFNGR1/TLR4/NFKBIE/JAK1/TLR2/BATF/EML4/STAT3/HIF1A/LAT	2.73827468633419
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	38/956	253/9376	1.47306795442142	NFKBIA/JUN/CD44/ACTB/IL1B/IL18/CD14/PYCARD/ARPC3/SQSTM1/ARPC1B/RRAGD/UBC/CASP1/C3/MAP1LC3B/TNF/CYTH4/TLR4/CYTH1/ACTR2/HK3/PLCB2/CCL5/ARPC4/ACTR3/NAIP/RHOA/TLR5/NLRP3/ITPR1/NLRC4/RIPK2/ITGB1/TLN1/ARHGEF2/DIAPH1/HK2	2.57023889685434
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	24/956	143/9376	1.64601925271381	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA1/FCGR3A/C1QB/C1QA/HLA-DMB/C1QC/HLA-DQA2/HLA-DRB5/FCGR1A/CD86/FCGR2A/C2/C3/HLA-DOA/TNF/CD40/IL10/FCGR3B	2.6230139517863
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	24/956	144/9376	1.63458856345886	NFKBIA/CXCL2/C1QB/C1QA/IL1B/CXCL3/LY96/C5AR1/C1QC/CD14/C3AR1/C2/C3/TNF/TLR4/PRKAG2/SCD/MAP3K5/ADIPOR1/CCND1/TCF7L1/CPT1A/IL17RA/ALDH2	2.58573567709576
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/956	44/9376	2.22898440471662	HEXB/HEXA/MAN1A1/MGAT1/MGAT4A/ALG3/ALG2/MAN2A1/STT3B/ALG13	2.75323881562462
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/956	15/9376	3.26917712691771	HEXB/HEXA/ST3GAL5/GLB1/SLC33A1	2.96354443080156
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	31/956	205/9376	1.48309011123584	HLA-B/HLA-A/HLA-C/NFKBIA/HLA-E/JUN/GSN/ATP6V0D1/HLA-F/LYN/CDKN1A/SYK/C3/REL/STAT5A/JAK1/SP100/RHOA/IL6ST/CREB5/PRKACB/RB1/STAT3/UBR4/CCND2/EGR2/CCR5/UBE3A/NFKB2/CCND1/CREB1	2.35643394401222
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/956	16/9376	3.06485355648536	HEXB/HEXA/GBGT1/GLA/NAGA	2.78528641931935
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	34/956	232/9376	1.43731063338624	TMSB4X/FN1/ITGB2/ACTB/RGCC/GSN/CXCR4/ITGAX/MSN/NCKAP1L/ARPC3/ARPC1B/IQGAP2/ITGAM/RAC2/GNA13/RRAS/ITGAL/ACTR2/VAV1/CFL1/ARPC4/ACTR3/ITGA4/RHOA/MRAS/PPP1R12A/ITGB1/ARHGEF6/DIAPH1/LIMK1/LPAR5/PAK2/PDGFC	2.27260762699634
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	17/956	98/9376	1.7013064640082	NR4A2/ATP1B1/CAMK1/NR4A1/ADCY7/CAMK1D/PLCB2/CAMK2D/PRKCB/CREB5/PRKACB/SCARB1/ITPR1/ATP2B1/POMC/KCNJ5/CREB1	2.35153926168039
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/956	69/9376	1.84779576738827	FCER1G/ALOX5AP/ALOX5/RAC2/LCP2/LYN/SYK/BTK/TNF/VAV1/PLA2G4C/INPP5D/LAT	2.38160356114298
NA	NA	hsa03272	Virion - Hepatitis viruses	10/956	48/9376	2.04323570432357	CD81/CD9/CD63/LAMP1/CHMP1B/LAMP2/TGOLN2/CLDN19/SCARB1/CHMP1A	2.44155960345785
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/956	138/9376	1.56351949548238	MT-ND2/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/MT-ND5/MT-CO3/ATP6V1F/ATP6V0B/MT-ND4L/ATP6V0D1/ATP6V0E1/TCIRG1/ATP6AP1/ATP6V1G1/ATP6V1B2/ATP6V0A1/ATP6V1A/MT-ATP8	2.24707748516618
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	14/956	77/9376	1.7831875237733	GADD45B/RAC2/STAT1/TGFBR1/CDKN1A/VEGFA/TGFBR2/JAK1/RB1/STAT3/RALGDS/ARHGEF6/CCND1/PLD1	2.32515301159481
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	30/956	203/9376	1.44938887400293	SPP1/FN1/JUN/ACTB/FLNA/PARVG/RAC2/ZYX/VEGFA/BIRC3/EMP1/HGF/VAV1/PARVB/PRKCB/ITGA4/RHOA/FLT1/PPP1R12A/CCND2/ITGB1/TLN1/DIAPH1/CCND1/COL1A2/THBS3/PAK2/PDGFC/VTN/VEGFB	2.18108794162997
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	31/956	212/9376	1.43412015473277	ITGB2/ACTB/GNAI2/APBB1IP/CSF1R/ITGAM/RAC2/LCP2/DOCK4/VEGFA/RASGRP3/FPR1/ADCY7/HGF/RRAS/ITGAL/VAV1/PLCB2/PRKCB/RHOA/FLT1/RASSF5/MRAS/LAT/ITGB1/RALGDS/TLN1/CSF1/LPAR5/PDGFC/VEGFB	2.15423896975677
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	22/956	140/9376	1.54118350268978	SPP1/GNAI2/SERPINE1/EGR1/KLF2/SLC8A1/TGFBR1/MAP1LC3B/ADCY7/MEF2A/PRKAG2/GNA13/RRAS/MEF2C/PIK3R5/PLCB2/SPHK1/PRKACB/MRAS/GNGT2/ITPR1/CCND1	2.17382782538841
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/956	109/9376	1.61959233810602	NFKBIA/CD36/SOCS3/TNF/PRKAG2/NR1H3/MLXIP/SLC27A1/PRKCB/RPS6KA1/CREB5/STAT3/RPS6KA2/G6PC3/RPS6KA3/PTPN1/CPT1A/CREB1	2.19234170062968
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	30/956	205/9376	1.43524849474436	CTSD/CYBA/MT-ND2/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/MT-ND5/MT-CO3/CD36/NCF2/MT-ND4L/CYBB/MMP9/RAC2/TGFBR1/COL3A1/NCF4/PDK4/TGFBR2/NCF1/PPIF/PLCB2/CAMK2D/PRKCB/MT-ATP8/COL1A2	2.1230704235946
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	20/956	125/9376	1.5692050209205	CTSD/FCER1G/ASAH1/GNAI2/RAC2/BID/TNF/GNA13/PLCB2/CERS6/PRKCB/SGMS2/SPHK1/RHOA/S1PR4/ADORA3/MAP3K5/SGPL1/PLD1/ORMDL1	2.15867830547861
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	24/956	157/9376	1.49924046584761	HLA-B/HLA-A/HLA-C/HLA-E/GADD45B/SERPINE1/ZFP36L2/HLA-F/SQSTM1/TGFBR1/CDKN1A/ZFP36L1/HIPK2/IGFBP3/TGFBR2/RRAS/RASSF5/MRAS/RB1/ITPR1/CCND2/IL1A/CCND1/TSC1	2.12557403875917
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	18/956	110/9376	1.60486877139597	SERPINE1/CYBB/IFNGR2/TIMP1/HMOX1/IL6R/CDKN1A/VEGFA/IFNGR1/TLR4/HK3/PFKFB3/CAMK2D/PRKCB/FLT1/STAT3/HIF1A/HK2	2.15015563302289
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/956	18/9376	2.72431427243143	HEXB/HEXA/FUCA1/MANBA/GLB1	2.46728713168554
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/956	73/9376	1.74654668424371	BST2/CXCR4/SAMHD1/CD4/ELL2/APOBEC3C/MX2/MDFIC/MX1/APOBEC3G/APOBEC3A/CCNT1/CCR5	2.15757265413602
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/956	38/9376	2.06474344857961	PTPRC/CD4/BTK/IL2RG/CD40/CIITA/IL7R/TAP1	2.21599297158816
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/956	75/9376	1.69997210599721	GADD45B/SERPINE1/BID/CDKN1A/CD82/IGFBP3/SESN3/CCND2/CCND1/TNFRSF10A/ZMAT3/BBC3/ZNF385A	2.05071393124406
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/956	32/9376	2.14539748953975	GAA/HK3/GALM/G6PC3/GLA/HK2/GLB1	2.18687187769596
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/956	83/9376	1.65428240157282	NFKBIA/IL1B/CCL4/SAMHD1/IL18/IFI16/PYCARD/DNASE2/CASP1/TREX1/CCL5/CXCL10/NLRP3/MLKL	2.01736673489662
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/956	68/9376	1.73074083189761	BCL2A1/SPI1/FCGR1A/CD14/CSF1R/ITGAM/STAT5A/RUNX1/STAT3/PIM1/CCND1/TCF7L1	2.03773724268035
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	24/956	163/9376	1.44405370023359	NFKBIA/FOS/JUN/MMP9/BID/STAT1/TGFBR1/CDKN1A/ATP6AP1/TNF/TLR4/TGFBR2/STAT5A/JAK1/TLR2/STAT6/PRKCB/STAT2/CREB5/RB1/STAT3/EGR2/IFIH1/CREB1	1.92702477627699
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	37/956	275/9376	1.31955876759224	HSPA1A/CYBA/MT-ND2/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/MT-ND5/MT-CO3/C1QB/C1QA/HSPA1B/IL1B/NCF2/MT-ND4L/C1QC/CYBB/TUBA1A/EGR1/PRNP/RAC2/NCF4/HSPA6/TNF/NCF1/PPIF/CCL5/CREB5/PRKACB/ITPR1/TUBB2A/MT-ATP8/IL1A/CREB1	1.81230407058983
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/956	149/9376	1.44809188172194	FCER1G/SYK/ADCY7/CYTH4/AGPAT2/CYTH1/GNA13/RRAS/PIK3R5/PLCB2/LPAR6/SPHK1/RHOA/MRAS/PLA2G4C/RALGDS/DGKH/PLD1/LPAR5/AGPAT3/PDGFC/TSC1	1.8577552109743
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	47/956	362/9376	1.27335352181049	SPP1/FN1/CSH1/SGK1/CSH2/EREG/CSF1R/OSM/MCL1/IGF2/IL6R/CDKN1A/SYK/PIK3AP1/VEGFA/NR4A1/IL2RG/TLR4/HGF/SGK3/JAK1/PIK3R5/TLR2/AREG/IL7R/LPAR6/ITGA4/FLT1/CREB5/PKN2/GNGT2/G6PC3/CCND2/ITGB1/CSF1/CCND1/COL1A2/THBS3/LPAR5/PDGFC/VTN/TSC1/CSF3R/DDIT4/VEGFB/IL4R/CREB1	1.78722290033456
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/956	21/9376	2.33512651922694	DSE/CHST11/CSGALNACT2/CHST13/B3GAT3	2.06380524712158
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/956	87/9376	1.57822344058096	FOS/JUN/GADD45B/EREG/RAC2/TGFBR1/CDKN1A/TGFBR2/AREG/RHOA/RALGDS/CCND1/TCF7L1/BBC3	1.82569983789946
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/956	130/9376	1.43340843257161	NFKBIA/FOS/JUN/GNAI2/MMP9/ARRB2/TGFBR1/VEGFA/COL3A1/ADCY7/GNA15/TGFBR2/PLCB2/CREB5/PRKACB/GNGT2/COL1A2/VEGFB/CREB1	1.67668171071825
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/956	51/9376	1.73074083189761	PLD3/PLA2G7/LPCAT2/TMEM86A/LPCAT1/PLA2G4C/PLD4/PLD1/ENPP2	1.76312288149178
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/956	37/9376	1.85547890987222	IL1B/IL18/ICAM1/TNF/PLCB2/IL10/PRKCB	1.75678461824282
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	29/956	217/9376	1.31068391724351	FOS/JUN/GNAI2/KLF4/ARRB2/AHR/VEGFA/MGST1/NOTCH2/ADCY7/STAT5A/GSTO1/PRKCB/RPS6KA1/MGST2/MIR29A/CREB5/PRKACB/BCL6/VDR/RB1/STAT3/RPS6KA2/CYP1B1/RPS6KA3/KPNA6/CCND1/CREB1/KPNA1	1.56021032750517
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/956	52/9376	1.69745735436112	ALOX5/ADCY7/PTGS2/PRKACB/HSD17B1/PLA2G4C/SCARB1/CYP1B1/HSD17B2	1.69932613224891
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/956	30/9376	1.96150627615063	IL1B/ABCC3/TNF/MTHFR/FOLR3/FOLR2	1.77729042433693
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	31/956	235/9376	1.29375945873765	MT-ND2/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/MT-ND5/MT-CO3/ACTB/MT-ND4L/ACSL1/ADCY7/PRKAG2/ACSL3/MGLL/RPS6KA1/CREB5/PRKACB/MAP3K5/RPS6KA2/RPS6KA3/ARID1A/MT-ATP8/SLC25A20/CPT1A/ACSL5/KDM3B/TSC1/CREB1	1.53669427950447
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/956	38/9376	1.80665051750716	HEXB/HEXA/RENBP/HK3/CHIT1/HK2/UAP1L1	1.67883810856824
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/956	61/9376	1.60779202963166	FTL/FTH1/SLC8A1/HMOX1/ATP1B1/ATOX1/VDR/ATP2B1/SLC30A1/CYBRD1	1.60467478011507
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/956	62/9376	1.58185990012147	ATXN1/NOTCH2/LFNG/NUMB/MFNG/PTCRA/MAML1/HES1/ADAM17/DTX3L	1.54883336130764
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/956	56/9376	1.57621040047818	MAN1A1/MGAT1/MGAT4A/ALG3/ALG2/MAN2A1/ALG5/STT3B/ALG13	1.45722189798402
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	21/956	156/9376	1.32024460894754	CD81/NFKBIA/BID/STAT1/SOCS3/CDKN1A/TNF/MX2/NR1H3/JAK1/OAS2/CXCL10/MX1/OAS1/CLDN19/STAT2/RB1/STAT3/SCARB1/CFLAR/CCND1	1.35905553839956
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/956	122/9376	1.36662322518691	CSH1/FOS/JUNB/GNAI2/CSH2/STAT1/SOCS3/ADCY7/IGFBP3/STAT5A/PLCB2/PRKCB/CREB5/PRKACB/STAT3/ITPR1/CREB1	1.37338936458246
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/956	12/9376	2.45188284518828	ASGR1/FCGR2B/NPC1	1.69570395437671
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/956	41/9376	1.67445657720176	TYMP/MMP9/HBEGF/CDKN1A/VEGFA/RB1/CCND1	1.45830142445109
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/956	65/9376	1.50885098165433	NCEH1/NR4A1/ADCY7/PLCB2/CREB5/PRKACB/SCARB1/ITPR1/POMC/CREB1	1.38709967591757
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/956	34/9376	1.73074083189761	PRKAG2/PER1/FBXL3/DBP/PER3/CREB1	1.43827337479958
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/956	42/9376	1.63458856345886	AOC1/IL4I1/KYNU/CYP1B1/HAAO/CAT/ALDH2	1.38880581580801
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/956	59/9376	1.49606410892844	GPX1/MGST1/LAP3/GSTO1/ANPEP/GPX4/MGST2/TXNDC12/HPGDS	1.28790640461426
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	22/956	170/9376	1.26920994339158	JUN/ACTB/TUBA1A/MSN/ARPC3/MYL6/ARPC1B/WAS/PRKAG2/ACTR2/ARPC4/CLDN19/ACTR3/RHOA/PRKACB/RUNX1/F11R/MAP3K5/ITGB1/CD1D/ARHGEF2/CCND1	1.19354448590577
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/956	69/9376	1.42138135952944	CTSB/GNAI2/PTGER4/KCNMA1/PLCB2/PRKACB/KCNJ2/ITPR1/PTGER2/CREB1	1.1837324330436
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/956	53/9376	1.48038209520802	SLC8A1/ATP1B1/PLCB2/PRKCB/PRKACB/VDR/ATP2B1/AP2S1	1.18169512340559
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	14/956	104/9376	1.32024460894754	PLD3/LPCAT2/PLA2G15/AGPAT2/GPCPD1/SGMS2/LPCAT1/PLA2G4C/PLD4/DGKH/LPGAT1/PLD1/AGPAT3/CDIPT	1.10654816991938
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/956	139/9376	1.27004003491767	CTSD/HSPA1A/FOS/JUN/HSPA1B/GNAI2/MMP9/HBEGF/HSPA6/ADCY7/PLCB2/CREB5/PRKACB/FKBP5/ITPR1/POMC/KCNJ5/CREB1	1.08075840667612
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/956	105/9376	1.30767085076708	JUN/SQSTM1/UBC/MITF/GABARAPL1/MAP1LC3B/RRAS/GABARAP/BNIP3L/MRAS/HIF1A/GABARAPL2/AMFR/USP8	1.06825823653823
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/956	22/9376	1.7831875237733	AOC1/HNMT/ALDH3B1/ALDH2	1.23918730822872
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/956	97/9376	1.31441142216279	FOS/GNAI2/ADCY7/PLCB2/CAMK2D/PRKCB/PRKACB/GNGT2/ITPR1/PER1/KCNJ5/PER3/CREB1	1.04879868310855
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/956	63/9376	1.40107591153616	HPGD/LTA4H/ALOX5/TBXAS1/PTGS2/PTGS1/GPX4/PLA2G4C/HPGDS	1.07624362268533
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/956	23/9376	1.70565763143533	CTSA/ATP6AP2/ANPEP/NLN	1.14167116439391
NA	NA	hsa04981	Folate transport and metabolism	5/956	31/9376	1.58185990012147	SLCO2B1/ABCC3/MTHFR/FOLR3/FOLR2	1.09337253575109
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	13/956	99/9376	1.28785765605849	FOS/JUN/RAC2/WAS/GPCPD1/PRKCB/PLA2G4C/HIF1A/RALGDS/DGKH/PLD1/PDGFC/TSC1	0.970175140800176
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/956	73/9376	1.34349744941824	GADD45B/CDKN1A/HGF/STAT5A/PRKCB/RASSF5/RB1/EML4/STAT3/CCND1	0.992731893761011
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/956	48/9376	1.4302649930265	ATP1B1/HK3/PLCB2/PRKCB/G6PC3/SLC2A5/HK2	1.00698013057052
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/956	65/9376	1.3579658834889	LPL/GK/AGPAT2/AKR1A1/MGLL/GLA/DGKH/AGPAT3/ALDH2	0.975795230585399
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/956	75/9376	1.30767085076708	GPX1/ATP1B1/ADCY7/ASGR1/PLCB2/PRKCB/CREB5/PRKACB/ITPR1/CREB1	0.901385775947317
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/956	93/9376	1.26548792009718	JUN/EGR1/MAP3K2/HBEGF/ADCY7/PLCB2/CAMK2D/PRKCB/PRKACB/PLA2G4C/ITPR1/PLD1	0.866963079051431
Organismal Systems	Digestive system	hsa04970	Salivary secretion	12/956	93/9376	1.26548792009718	LYZ/CST3/ATP1B1/ADCY7/KCNMA1/PLCB2/PRKCB/BST1/PRKACB/ITPR1/ATP2B1/CD38	0.866963079051431
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/956	238/9376	1.15382722126508	CSF1R/RAC2/IGF2/VEGFA/RASGRP3/REL/ABL2/HGF/RRAS/PRKCB/RHOA/FLT1/RASSF5/PRKACB/MRAS/GNGT2/PLA2G4C/RASA4/RASA3/LAT/RALGDS/CSF1/PLD1/RASAL3/PAK2/PDGFC/VEGFB/ETS2	0.809943333706108
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/956	67/9376	1.31742958845938	FBP1/AKR1A1/ALDH3B1/HK3/GALM/G6PC3/HK2/ADPGK/ALDH2	0.878601278389359
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/956	33/9376	1.48598960314442	VAMP8/STX11/VAMP5/STX4/STX7	0.942321960948998
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/956	76/9376	1.29046465536225	ACTB/GNAI2/ATP1B1/ADCY7/PLCB2/CAMK2D/PRKCB/PRKACB/KCNJ2/ITPR1	0.856677092603016
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/956	166/9376	1.18163028683773	GNAI2/RGS2/SLC8A1/ATP1B1/ADCY7/MEF2A/GNA13/MEF2C/KCNMA1/PIK3R5/PPIF/PLCB2/RHOA/CREB5/ADORA3/PPP1R12A/ITPR1/ATP2B1/KCNMB1/CREB1	0.795556514410656
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/956	17/9376	1.73074083189761	LAMP1/LAMP2/NRP2	1.01608876864404
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/956	86/9376	1.25445168823587	JUN/EREG/HBEGF/CDKN1A/ABL2/STAT5A/CAMK2D/AREG/PRKCB/PAK2/CBLB	0.798739650434838
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/956	122/9376	1.20584402222375	NFKBIA/FOS/JUN/PTPRC/CD4/LCP2/PTPN6/TNF/NFKBIE/VAV1/IL10/RHOA/LAT/PAK2/CBLB	0.771102241929274
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/956	60/9376	1.30767085076708	HSPB1/RAC2/VEGFA/MAPKAPK3/PTGS2/PRKCB/SPHK1/PLA2G4C	0.805574622173695
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/956	78/9376	1.25737581804527	FN1/ACTB/ARPC3/ARPC1B/ACTR2/ARPC4/ACTR3/RHOA/RHOG/ITGB1	0.769092912194734
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/956	18/9376	1.63458856345886	ACSL1/ACSL3/ACSL5	0.908020203491714
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/956	35/9376	1.40107591153616	FBP1/HSD17B14/HK3/PFKFB3/HK2	0.800981441873012
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/956	79/9376	1.24145966844976	ATP6V1F/ATP6V0B/ATP6V0D1/ATP6V0E1/TCIRG1/ATP6V1G1/ATP6V1B2/ATP6V0A1/AP2S1/ATP6V1A	0.726181647087674
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/956	62/9376	1.26548792009718	HSPA1A/SOD2/HSPA1B/HSPA6/ADCY7/PRKAG2/PRKACB/CAT	0.70669339403668
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/956	71/9376	1.24320820319406	FOS/STAT1/SOCS3/STAT5A/IRF1/STAT3/CCND2/TNFRSF11A/CCND1	0.693118903276138
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	18/956	155/9376	1.13893912808746	GNAI2/NCEH1/AHR/CDKN1A/NR4A1/ADCY7/PLCB2/CAMK2D/CREB5/PRKACB/RB1/SCARB1/ITPR1/POMC/CCND1/TCF7L1/CREB1/USP8	0.587705758126156
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/956	110/9376	1.15907189045264	EMP3/HAMP/ID2/TGFBR1/FBN1/SKIL/TNF/TGFBR2/RHOA/SMAD7/DCN/NOG/RGMB	0.565460373368238
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/956	20/9376	1.47112970711297	NPL/CYB5R4/UAP1L1	0.710671532895418
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	18/956	157/9376	1.12443034938571	MT-CO1/MT-CYB/FOS/MT-CO2/MT-CO3/JUN/IL1B/BID/SOCS3/IL6R/TNF/PRKAG2/NR1H3/MLXIP/MAP3K5/ADIPOR1/ERN1/IL1A	0.529776607428951
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	14/956	120/9376	1.1442119944212	NFKBIA/JUN/ARHGDIB/MATK/SH2B3/NFKBIE/CAMK2D/IRAK3/RPS6KA1/RHOA/MAP3K5/RPS6KA2/RIPK2/RPS6KA3	0.535721247810662
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/956	47/9376	1.25202528264934	ME2/AKR1A1/ME1/ME3/ALDH2/ACYP2	0.583625194267046
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/956	93/9376	1.16003059342241	ACTB/RAC2/PTPN6/TGFBR1/WAS/TGFBR2/RHOA/PTPRJ/HEG1/PTPN1/TCF7L1	0.522587302522613
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	9/956	75/9376	1.17690376569038	BID/CDKN1A/BIRC3/MGST1/GSTO1/MGST2/MAP3K5/ERCC1/BBC3	0.518276390848403
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	28/956	254/9376	1.08114519157909	CXCR4/SLC8A1/VEGFA/PTAFR/CAMK1/ADCY7/GNA15/HGF/ORAI3/P2RX7/CAMK1D/PPIF/PLCB2/ORAI2/P2RX4/CAMK2D/PRKCB/TPCN1/SPHK1/FLT1/PRKACB/MCOLN1/ASPH/ITPR1/ATP2B1/CD38/PDGFC/VEGFB	0.441766879904977
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/956	57/9376	1.2044336783381	PPT1/ACSL1/ACSL3/SCD/CPT1A/ACSL5/ELOVL5	0.521631432728038
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/956	67/9376	1.171048523075	PLCB2/CAMK2D/PRKCB/RPS6KA1/PRKACB/RPS6KA2/ITPR1/RPS6KA3	0.47343869791628
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/956	86/9376	1.14041062566897	ATP1B1/ADCY7/KCNMA1/PLCB2/CAMK2D/PRKCB/CREB5/PRKACB/KCNMB1/CREB1	0.440757673260983
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/956	49/9376	1.20092220988814	JUN/FOSB/GNAI2/CREB5/PRKACB/CREB1	0.475131185396468
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/956	77/9376	1.14633483671141	NFKBIA/GADD45B/TGFBR1/CDKN1A/TGFBR2/STAT5A/RUNX1/RB1/CCND1	0.434443700841243
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/956	115/9376	1.10867746043296	FOS/GNAI2/ADCY7/PIK3R5/PLCB2/CAMK2D/PRKCB/CREB5/PRKACB/GNGT2/KCNJ2/ITPR1/CREB1	0.39510997853828
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	29/956	268/9376	1.06126272403672	DUSP1/MT-ND2/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/MT-ND5/MT-CO3/MT-ND4L/GNAI2/TUBA1A/UBE2L6/UBC/NFE2L2/PPIF/CAMK2D/LRRK2/SLC39A11/PRKACB/MAP3K5/ITPR1/TUBB2A/ERN1/MT-ATP8/SNCA/UBA7	0.342855190268897
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/956	59/9376	1.16360541805546	GNAI2/FABP4/ADCY7/PTGS2/PTGS1/MGLL/PRKACB	0.424760554030751
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/956	69/9376	1.13710508762355	FOS/JUN/FOSB/CAMK2D/PRKCB/CREB5/PRKACB/CREB1	0.385151680977346
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/956	60/9376	1.1442119944212	GNAI2/LYN/GNA13/PLCB2/PRKCB/PLA2G4C/ITPR1	0.377590280746873
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/956	32/9376	1.22594142259414	GABARAPL1/GABARAP/GABARAPL2/ATG3	0.431382945737285
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/956	70/9376	1.12086072922893	MGST1/PTGS2/SULT1A1/GSTO1/MGST2/CYP1B1/HPGDS/HSD11B1	0.341988297188785
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/956	89/9376	1.10196981806215	GNAI2/TUBA1A/MAP3K2/ADCY7/PLCB2/PRKCB/PRKACB/ITPR1/TUBB2A/PDGFC	0.325677280992249
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/956	99/9376	1.08972570897257	IL1B/PTGER4/TRPV2/ADCY7/PLCB2/CAMK2D/PRKCB/PRKACB/PLA2G4C/ITPR1/PTGER2	0.302405200986459
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/956	90/9376	1.08972570897257	SOD2/ADCY7/PRKAG2/CREB5/PRKACB/SESN3/ADIPOR1/CAT/TSC1/CREB1	0.28819228621578
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	17/956	158/9376	1.0552407181823	ATP6V1F/SGK1/RRAGD/TNF/ATP6V1G1/ATP6V1B2/SLC7A5/PRKCB/RPS6KA1/RHOA/FNIP2/RPS6KA2/RPS6KA3/ATP6V1A/FNIP1/TSC1/DDIT4	0.235954381540646
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/956	226/9376	1.04150775724812	NFKBIA/FOS/JUN/GNAI2/ATP1B1/RAC2/ADCY7/SUCNR1/RRAS/VAV1/CAMK2D/RHOA/CREB5/PRKACB/PDE4B/PPP1R12A/ATP2B1/PDE4A/POMC/PTGER2/HCAR3/PLD1/HCAR2/CREB1	0.212829330706871
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/956	43/9376	1.14041062566897	ACSL1/ACSL3/CPT1A/ACSL5/ALDH2	0.310943947719321
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/956	43/9376	1.14041062566897	CD36/ABCA1/AGPAT2/SLC27A1/SCARB1	0.310943947719321
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/956	149/9376	1.05315773216141	MT-ND2/MT-ND4/MT-ND1/MT-ND3/MT-ND5/MT-ND4L/GNAI2/ADCY7/PTGS2/PLCB2/MGLL/PRKCB/PRKACB/GNGT2/ITPR1/KCNJ5	0.220387956030228
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	18/956	170/9376	1.03844449913857	ACTB/GADD45B/HMOX1/IGF2/TGFBR1/CDKN1A/MGST1/NFE2L2/HGF/TGFBR2/GSTO1/PRKCB/MGST2/RB1/ARID2/ARID1A/CCND1/TCF7L1	0.170444001369978
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/956	44/9376	1.11449220235831	ARHGDIB/STX4/CREB5/PRKACB/CREB1	0.256491762148874
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/956	54/9376	1.08972570897257	SDS/IL4I1/SDSL/LACC1/MAT2B/MAT2A	0.222801324262251
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	13/956	122/9376	1.04506481926058	FBP1/CD36/PRKAG2/PFKFB3/CREB5/SCD/G6PC3/ADIPOR1/CCND1/RAB10/CPT1A/TSC1/CREB1	0.168815119276086
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/956	16/9376	1.22594142259414	IL4I1/ALDH3B1	0.304772982053181
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/956	65/9376	1.05619568715803	SPP1/ARRB2/PLCB2/PRKCB/KISS1/ITPR1/KCNJ5	0.153186339921067
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/956	36/9376	1.08972570897257	GAA/HK3/G6PC3/HK2	0.181741140657528
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/956	46/9376	1.06603601964708	FTL/FTH1/HMOX1/BLVRA/BLVRB	0.1512786083343
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/956	174/9376	1.01457221180205	HSPA1A/HSPA1B/DNAJB1/PPP1R15A/MAN1A1/HSPA6/NFE2L2/BCAP31/DNAJC5B/MAP3K5/HSPH1/DERL2/HERPUD1/OS9/AMFR/STT3B/STUB1/ERN1	0.0653758762986949
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	24/956	233/9376	1.01021782462693	VIM/FN1/ACTB/SDC2/ATP1B1/FMNL1/ZYX/FMNL2/COL3A1/FBN1/SNTB1/PLEC/ITGA4/PDLIM7/DCN/FMNL3/SDC3/AMPD3/ITGB1/TLN1/DIAPH1/SYNE1/COL1A2/THBS3	0.0532170239191208
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/956	115/9376	1.0233945788612	DUSP1/GNAI2/ALOX5/PTGS2/PTGS1/PLCB2/PRKCB/PRKACB/GNGT2/PLA2G4C/ITPR1/KCNJ5	0.0850538052226695
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/956	184/9376	1.01273421866473	CXCR4/GNAI2/PLXNC1/RAC2/SEMA3C/DPYSL2/RRAS/CFL1/CAMK2D/SEMA4A/EPHB2/RHOA/NRP1/PLXNB2/ITGB1/LIMK1/EPHB6/PAK2/PLXNA2	0.0587806988717324
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/956	76/9376	1.0323717242898	GADD45B/CDKN1A/CAMK1/CAMK1D/CAMK2D/PRKCB/RB1/CCND1	0.0954750057715263
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/956	106/9376	1.01776269045551	NFKBIA/MMP9/CDKN1A/CREB5/RB1/FOLR3/FOLR2/CCND1/TCF7L1/PDGFC/CREB1	0.0619698366988428
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/956	17/9376	1.15382722126508	CYP27A1/HSD3B7	0.213895412732411
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/956	37/9376	1.06027366278412	GADD45B/CDKN1A/CCND1/TCF7L1	0.123776100664035
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/956	107/9376	1.00825088961014	FBP1/SIK1/PRKAG2/PLCB2/CAMK2D/CREB5/PRKACB/G6PC3/ITPR1/CPT1A/CREB1	0.0289224289595937
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/956	38/9376	1.0323717242898	NAMPT/BST1/SIRT2/CD38	0.0673735195084714
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/956	99/9376	0.99065973542961	FOS/JUN/MMP9/HBEGF/CDKN1A/NOTCH2/ADCY7/PRKACB/RB1/CCND1	-0.0314797689203989
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/956	89/9376	0.991772836255935	SPP1/FN1/CD44/CD36/ITGA4/ITGB1/COL1A2/THBS3/VTN	-0.0262764057969775
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/956	89/9376	0.991772836255935	GLUL/GNAI2/GABARAPL1/ADCY7/GABARAP/PRKCB/PRKACB/GNGT2/GABARAPL2	-0.0262764057969775
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/956	59/9376	0.997376072618963	TYMP/DPYD/UPP1/ENTPD1/CDA/TK2	-0.00681237126100474
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/956	49/9376	1.00076850824012	LFNG/GALNT7/MFNG/COLGALT1/POGLUT1	0.00181733135085776
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/956	80/9376	0.980753138075314	IL6R/VEGFA/AXL/HGF/JAK1/PRKCB/STAT3/PDGFC	-0.0582526122342571
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/956	101/9376	0.971042710965657	GNAI2/MITF/ADCY7/PLCB2/CAMK2D/PRKCB/PRKACB/POMC/TCF7L1/CREB1	-0.0985871171587341
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/956	91/9376	0.969975631063497	GNAI2/ARRB2/ADCY7/PRKCB/PRKACB/GNGT2/PDE4B/PDE4A/KCNJ5	-0.0969755315385011
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/956	102/9376	0.961522684387563	ATP1B1/ADCY7/KCNMA1/PLCB2/PRKCB/RHOA/BST1/ITPR1/ATP2B1/CD38	-0.13165272246109
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/956	82/9376	0.956832329829574	TYMP/DPYD/UPP1/MGST1/GSTO1/MGST2/CDA/TK2	-0.132288697486321
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/956	103/9376	0.952187512694479	SLC7A7/SLC8A1/ATP1B1/COL3A1/SLC16A10/COL17A1/KCNE3/COL8A2/COL15A1/COL1A2	-0.164402477608987
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/956	93/9376	0.949115940072884	FN1/NFKBIA/GADD45B/CDKN1A/BIRC3/PTGS2/RB1/ITGB1/CCND1	-0.166164250535023
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/956	20/9376	0.980753138075314	LIPA/SOAT1	-0.0290327624451059
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/956	31/9376	0.949115940072884	HSD17B14/AKR1A1/ALDH2	-0.0956162018042596
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/956	31/9376	0.949115940072884	DPYD/ALDH3B1/ALDH2	-0.0956162018042596
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/956	31/9376	0.949115940072884	GLUL/CS/CAT	-0.0956162018042596
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/956	73/9376	0.940448214592767	GADD45B/CDKN1A/MITF/HGF/RB1/CCND1/PDGFC	-0.172108866613998
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/956	116/9376	0.930024527485211	FBP1/SDS/SDSL/ME2/HK3/ME1/CS/ME3/HK2/CAT/ADPGK	-0.255521753791768
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/956	116/9376	0.930024527485211	GLUL/GNAI2/HOMER3/ADCY7/PLCB2/PRKCB/PRKACB/GNGT2/PLA2G4C/ITPR1/PLD1	-0.255521753791768
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/956	21/9376	0.934050607690775	DPYD/ALDH2	-0.101942924458624
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/956	32/9376	0.919456066945607	BID/BIRC3/BBC3	-0.153780031582273
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/956	10/9376	0.980753138075314	PAPSS2	-0.0205183008131613
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/956	87/9376	0.901841966046266	MT-CO1/MT-CYB/MT-CO2/MT-CO3/SLC8A1/ATP1B1/CACNA2D4/ASPH	-0.309927087178974
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/956	66/9376	0.891593761886649	DHRS9/HSD17B1/CYP1B1/HSD17B11/HSD11B1/HSD17B2	-0.297789883451835
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/956	45/9376	0.871780567178057	ABCA1/ABCC3/ABCG1/TAP1	-0.290505629182445
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/956	56/9376	0.875672444710102	ARRB2/PRKACB/CCND2/CSNK1G3/CCND1	-0.314421322386593
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/956	79/9376	0.869021767914835	MGST1/ALDH3B1/GSTO1/MGST2/CYP1B1/HPGDS/HSD11B1	-0.393912527582325
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/956	122/9376	0.884285616297414	ACTB/ATP1B1/STAT1/SLC16A10/NOTCH2/MED13L/PLCB2/PRKCB/PRKACB/HIF1A/CCND1	-0.433472003377103
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/956	154/9376	0.891593761886649	GNAI2/SLC8A1/ATP1B1/ADCY7/PIK3R5/PLCB2/CAMK2D/CACNA2D4/CREB5/PRKACB/ATP2B1/CREM/KCNE1/CREB1	-0.457046738306941
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/956	133/9376	0.884890049391261	FOS/GNAI2/ARRB2/PLCB2/CAMK2D/PRKCB/CREB5/PRKACB/GNGT2/ITPR1/KCNJ5/CREB1	-0.450495803884592
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/956	24/9376	0.817294281729428	HS3ST1/B3GAT3	-0.30197017478521
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/956	47/9376	0.834683521766225	SOCS3/TNF/HK3/HK2	-0.382830090340482
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/956	12/9376	0.817294281729428	GGCX	-0.213388297813016
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/956	134/9376	0.878286392306251	MYL6/ADCY7/GNA13/KCNMA1/PLCB2/PRKCB/RHOA/PRKACB/PLA2G4C/PPP1R12A/ITPR1/KCNMB1	-0.478153227025558
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/956	70/9376	0.840645546921698	JUN/CDKN1A/VEGFA/HGF/HIF1A/PAK2	-0.450910385907666
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/956	37/9376	0.795205247088092	IL4I1/ALDH3B1/FAHD1	-0.420560071862227
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/956	37/9376	0.795205247088092	HK3/HK2/UAP1L1	-0.420560071862227
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/956	72/9376	0.817294281729428	NFKBIA/TNF/CXCL10/ISG15/CYLD/IFIH1	-0.52437511803567
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/956	105/9376	0.840645546921698	ACTB/SLC8A1/TNF/ADCY7/SNTB1/ITGA4/CACNA2D4/PRKACB/ITGB1	-0.553291631643101
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/956	38/9376	0.774278793217353	SGK1/ATP1B1/PRKCB	-0.469781343511451
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/956	26/9376	0.754425490827164	HHEX/HES1	-0.42249608778325
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/956	26/9376	0.754425490827164	TCN2/SCARB1	-0.42249608778325
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/956	50/9376	0.784602510460251	SAT1/AOC1/LAP3/ALDH2	-0.514560532870773
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/956	39/9376	0.754425490827164	MTHFR/MAT2B/MAT2A	-0.517810016785544
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/956	85/9376	0.807679054885553	TYMP/UPP1/ENTPD1/CDA/TK2/AMPD3/LACC1	-0.600154899581793
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/956	27/9376	0.726483805981714	SCD/ELOVL5	-0.479557718526335
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/956	86/9376	0.798287437968279	ACTB/SLC8A1/SNTB1/ITGA4/CACNA2D4/ITGB1/TCF7L1	-0.633188258260582
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/956	75/9376	0.784602510460251	GLUL/SDS/SDSL/CS/MAT2B/MAT2A	-0.631051764448339
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/956	142/9376	0.82880546879604	UBE2L6/UBC/SOCS3/BIRC3/UBE2Z/CUL4B/UBE3A/STUB1/CUL5/UBE2E1/CBLB/UBA7	-0.692624201889914
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/956	28/9376	0.700537955768081	PPT1/ELOVL5	-0.534712069764549
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/956	99/9376	0.792527788343688	ACTB/SLC8A1/TNF/PRKAG2/SNTB1/ITGA4/CACNA2D4/ITGB1	-0.699249708734115
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/956	29/9376	0.676381474534699	RASSF4/RASSF2	-0.588104890570082
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/956	78/9376	0.754425490827164	BTG1/BTG2/TOB1/PABPC1/CNOT8/CNOT1	-0.733828126725196
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/956	157/9376	0.812088585667457	ITGB2/ACTB/SERPINE1/ID2/TGFBR1/BIRC3/TGFBR2/AREG/SMAD7/CCND2/CCND1/TCF7L1/BBC3	-0.800054585346228
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/956	90/9376	0.7628079962808	NCEH1/AQP9/ATP1B1/ABCC3/ADCY7/PRKACB/SCARB1	-0.76184302812068
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/956	30/9376	0.653835425383542	GPAA1/PIGG	-0.639865801161046
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/956	68/9376	0.721142013290672	ALDH1A1/DHRS4L2/DHRS9/RDH10/DHRS3	-0.777620847408838
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/956	31/9376	0.63274396004859	BAG6/OXA1L	-0.690110570581936
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/956	17/9376	0.576913610632538	PAPSS2	-0.588297943179222
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/956	17/9376	0.576913610632538	GLUL	-0.588297943179222
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/956	138/9376	0.781759747741192	FBP1/RHOQ/SOCS3/PRKAG2/HK3/PRKACB/G6PC3/HK2/PTPN1/TSC1/CBLB	-0.870249851405693
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	34/956	388/9376	0.859422852952595	APOE/MT-ND2/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/MT-ND5/MT-CO3/IL1B/MT-ND4L/LPL/CYBB/TUBA1A/LRP1/BID/RTN4/TNF/PTGS2/PPIF/PLCB2/SLC39A11/MAP3K5/ITPR1/CSF1/TUBB2A/ADAM10/ERN1/MT-ATP8/ADAM17/IL1A/SNCA	-0.952922529220305
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/956	18/9376	0.544862854486285	TCN2	-0.651246724702116
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/956	46/9376	0.639621611788248	PSMB9/PSMB8/PSME2	-0.825572790937323
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/956	59/9376	0.664917381745975	GADD45B/CDKN1A/CCND1/TCF7L1	-0.869958221844516
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	42/956	480/9376	0.8581589958159	MT-ND2/GPX1/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/MT-ND5/MT-CO3/IL1B/MT-ND4L/CYBB/TUBA1A/UBE2L6/SQSTM1/UBC/PRNP/BID/TNFRSF1B/ATXN1/MAP1LC3B/TNF/PTGS2/PPIF/PLCB2/CAMK2D/LRRK2/PRKCB/ATXN2/MAP3K5/ITPR1/C9orf72/CSF1/TUBB2A/ERN1/MT-ATP8/IL1A/CAT/SNCA/UBA7	-1.07493837514237
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/956	73/9376	0.671748724709119	MGST1/ALDH3B1/GSTO1/MGST2/HPGDS	-0.948669373530671
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/956	110/9376	0.713275009509319	GNAI2/ADCY7/CPEB4/RPS6KA1/PRKACB/RPS6KA2/CPEB2/RPS6KA3	-1.01923488628641
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/956	63/9376	0.622700405127183	COLGALT1/SETDB2/SETD2/ALDH2	-1.01244246075101
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/956	37/9376	0.530136831392062	GLUL/IL4I1	-0.964896244388489
NA	NA	hsa04081	Hormone signaling	17/956	219/9376	0.761315221337001	CSH1/HAMP/GNAI2/CSH2/IGF2/SLC16A10/ADCY7/GNA15/GNA13/STAT5A/PLCB2/RHOA/PRKACB/GNGT2/STAT3/ADIPOR1/POMC	-1.20428343626893
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	25/956	308/9376	0.796065858827365	MT-ND2/GPX1/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/SOD2/MT-ND5/MT-CO3/MT-ND4L/TUBA1A/PPIF/PLCB2/CREB5/MAP3K5/ITPR1/AP2S1/TUBB2A/ERN1/MT-ATP8/BBC3/CREB1	-1.22621910802749
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/956	23/9376	0.426414407858832	GLUL	-0.927994117384381
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/956	23/9376	0.426414407858832	ZMPSTE24	-0.927994117384381
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/956	23/9376	0.426414407858832	POLD4	-0.927994117384381
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/956	23/9376	0.426414407858832	ATP1B1	-0.927994117384381
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	30/956	368/9376	0.79952701473531	MT-ND2/GPX1/MT-ND4/MT-ND1/MT-ND3/MT-ATP6/MT-CO1/MT-CYB/MT-CO2/MT-ND5/MT-CO3/ACTB/MT-ND4L/TUBA1A/SQSTM1/BID/CASP1/TNFRSF1B/MAP1LC3B/TNF/NUP214/ATXN2/MAP3K5/C9orf72/ANG/POM121/TUBB2A/ERN1/MT-ATP8/CAT	-1.32197766188443
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/956	178/9376	0.716280381740398	JUN/RAC2/NOTUM/MMP7/PLCB2/CAMK2D/PRKCB/RHOA/PRKACB/CCND2/RSPO3/CCND1/TCF7L1	-1.287689646925
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/956	41/9376	0.478416164914787	SDS/SDSL	-1.1277619277303
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/956	83/9376	0.590815143418864	SOD2/ACSL1/ACSL3/CAT/ACSL5	-1.26165080415716
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/956	26/9376	0.377212745413582	PLA2G4C	-1.07146779798242
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/956	71/9376	0.55253697919736	HK3/SLC7A5/HIF1A/HK2	-1.27522457779882
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/956	98/9376	0.60046110494407	PLCB2/PRKCB/ITPR1/INPP5D/DGKH/CDIPT	-1.33968734998205
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/956	148/9376	0.662671039240077	FOS/JUN/GADD45B/CDKN1A/NOTCH2/RB1/HES1/NFKB2/CCND1/TCF7L1	-1.39376396443418
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/956	138/9376	0.639621611788248	ADCY7/CPEB4/CAMK2D/RPS6KA1/PRKACB/RPS6KA2/CPEB2/ITPR1/RPS6KA3	-1.43703663987331
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/956	28/9376	0.350268977884041	GCH1	-1.1601437521638
NA	NA	hsa04082	Neuroactive ligand signaling	14/956	199/9376	0.689977082063035	GNAI2/ADCY7/PLCB2/P2RY11/P2RX4/PRKCB/ADORA3/PRKACB/GNGT2/AGRP/POMC/TAC3/OGFRL1/SLC17A9	-1.48945885417605
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/956	29/9376	0.33819073726735	PDE6G	-1.20269154393445
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/956	128/9376	0.612970711297071	PAPSS2/ADCY7/ENTPD1/PDE4B/PDE4A/AMPD3/LACC1/PDE6G	-1.48553690250199
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/956	154/9376	0.636852687061892	PDXK/KYNU/AKR1A1/HAAO/DHRS3/GGCX/GCH1/MAT2B/MAT2A/ALDH2	-1.5310492993009
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/956	30/9376	0.326917712691771	CS	-1.24415485753554
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/956	30/9376	0.326917712691771	PLA2G4C	-1.24415485753554
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/956	63/9376	0.467025303845387	POLD4/CUL4B/ERCC1	-1.43017967743827
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/956	63/9376	0.467025303845387	GADD45B/CDKN1A/TCF7L1	-1.43017967743827
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/956	48/9376	0.408647140864714	IL4I1/ALDH2	-1.38398565757504
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/956	144/9376	0.612970711297071	ATXN1/PPIF/PLCB2/PUM1/PRKCB/ATXN2/MAP3K5/ITPR1/ERN1	-1.57701461625071
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/956	31/9376	0.316371980024295	FBP1	-1.28460493935961
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	24/956	323/9376	0.728732981851626	VIM/MARCKS/CD44/TIMP3/ZEB2/MMP9/HMOX1/ST14/MCL1/CDKN1A/VEGFA/NOTCH2/PTGS2/FOXP1/PRKCB/RHOA/MIR29A/STAT3/PIM1/CYP1B1/SOX4/CCND2/CCND1/DDIT4	-1.67170843223649
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/956	33/9376	0.297197920628883	CS	-1.3627160525803
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/956	54/9376	0.363241902990857	ERCC1/HES1	-1.58115827529117
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/956	36/9376	0.272431427243143	AKR1A1	-1.47370406802607
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/956	36/9376	0.272431427243143	GALNT7	-1.47370406802607
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/956	36/9376	0.272431427243143	POLD4	-1.47370406802607
NA	NA	hsa04382	Cornified envelope formation	14/956	217/9376	0.63274396004859	S100A4/S100A9/S100A6/S100A10/S100A8/S100A11/ST14/DST/SLC27A1/COL17A1/PLEC/CLDN19/UGCG/PADI2	-1.84430746031099
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/956	144/9376	0.544862854486285	KLF4/ID2/SKIL/JAK1/IL6ST/PCGF3/STAT3/PCGF5	-1.85453130247381
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/956	117/9376	0.50295032721811	ACTB/BAZ2B/TFPT/ARID2/ARID1A/BAZ1A	-1.82292675727022
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/956	41/9376	0.239208082457394	POLD4	-1.64497459816658
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/956	150/9376	0.523068340306834	GADD45B/TGFBR1/CDKN1A/HGF/TGFBR2/RB1/CCND1/TCF7L1	-1.9840544913317
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/956	78/9376	0.377212745413582	PLCB2/INPP5D/CDIPT	-1.86101890591514
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/956	44/9376	0.222898440471662	TAF3	-1.74090588063172
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/956	44/9376	0.222898440471662	POLD4	-1.74090588063172
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/956	86/9376	0.342123187700691	PLCB2/PRKACB/PKD2L1	-2.065116166956
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	24/956	370/9376	0.636164197670474	CSH1/TSPO/C5AR1/CSH2/FPR3/C3AR1/PTGER4/C3/PTAFR/FPR1/P2RX7/P2RY11/P2RX4/LPAR6/S1PR4/ADORA3/KISS1/GPR35/NR3C1/POMC/TAC3/UTS2/PTGER2/OGFRL1	-2.4060179429158
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/956	108/9376	0.363241902990857	NUP214/POM121/KPNA6/KPNA1	-2.24260032072708
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/956	194/9376	0.454988569210197	ACTB/TUBA1A/MYL6/MYO1F/MYO5A/MYO9B/MYO1G/TUBB2A/KIF1C	-2.58461803470995
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/956	83/9376	0.236326057367546	PCGF3/PCGF5	-2.35465665050843
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/956	103/9376	0.285656253808344	RNMT/PABPC1/SMG7	-2.45625961661345
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/956	158/9376	0.372437900534929	GADD45B/CDKN1A/PDS5A/RB1/CCND2/CCND1	-2.68055941215256
NA	NA	hsa04519	Cadherin signaling	24/956	404/9376	0.582625626579394	VIM/NFKBIA/ACTB/LHFPL2/NCKAP1L/ARPC3/ARPC1B/RAC2/MYO1F/RRAS/ACTR2/VAV1/TMC6/ARPC4/ACTR3/RHOA/TAOK3/MRAS/MYO1G/CDH11/TMC8/ADAM10/TCF7L1/PCDH10	-2.88955103119862
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/956	191/9376	0.308089991018423	FOSB/GNAI2/CREB5/PRKACB/GNGT2/CREB1	-3.2552568010495
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/956	183/9376	0.0535930676543887	NOP10	-4.35645634262276
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/956	243/9376	0.121080634330286	HSPA1A/HSPA1B/HSPA6	-4.67739427948006
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/956	449/9376	0.109215271500592	RGS2/ARRB2/SLC8A1/CAMK2D/PRKACB	-6.51781012604432