category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	89/837	250/9376	3.98788052568698	PSAP/CTSD/NPC2/CTSZ/CTSB/LAPTM5/ACP5/CD68/CTSH/LIPA/LGMN/DNASE2/ATP6V0B/ATP6V1F/HEXB/PPT1/SCARB2/VAMP8/ATP6V0D1/CTSA/LAMP2/SLC15A3/ATP6AP1/ACP2/CTSC/CD63/HEXA/M6PR/LITAF/ARL8B/GNS/TPP1/OSTM1/GGA2/LAMP1/TCIRG1/BLOC1S2/ARL8A/ASAH1/PLA2G15/AP2S1/SLC17A5/GAA/MANBA/GNPTG/MITF/LAMTOR2/AP3S1/AP1B1/ATP6V0E1/IDS/ATP6V1G1/ATP6V1A/RAB7A/DMXL2/VPS13C/CTBS/SLC11A1/CLCN7/ATP6V1C1/GLB1/GGA1/SNAPIN/AP2M1/ATP6V1D/OSBPL1A/BLOC1S6/MCOLN1/CTSL/KXD1/OSBPL3/NAGPA/RRAGD/IGF2R/ARSB/GNPTAB/LAPTM4A/VPS26A/VPS35/SLC11A2/VPS41/CLTC/ATP6V1B2/SLC29A3/FUCA2/ARSA/LAMTOR3/NAGLU/TPCN1	14.9912504661561
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	58/837	155/9376	4.19168304620958	HLA-B/OLR1/HLA-DQA2/MSR1/HLA-DRA/FCGR3A/HLA-A/HLA-DPA1/C3/HLA-DMB/ATP6V0B/HLA-DPB1/ATP6V1F/HLA-F/CD36/ATP6V0D1/HLA-DQA1/HLA-C/FCGR1A/HLA-E/LAMP2/ITGB2/HLA-DMA/MARCO/ITGAV/ATP6AP1/CYBA/M6PR/HLA-DQB1/RAB5C/LAMP1/STX7/TAP1/TCIRG1/NCF2/ACTB/TFRC/ATP6V0E1/ATP6V1G1/ATP6V1A/RAB7A/DYNC1I2/ATP6V1C1/DYNC1LI1/ATP6V1D/CTSL/TLR2/RAC1/HLA-DRB1/ITGAM/HLA-DOA/CYBB/CANX/STX12/DYNC1H1/EEA1/ATP6V1B2/SEC61A1	12.5441562571826
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	35/837	82/9376	4.78130372701577	B2M/HLA-B/HSPA1A/HSPA1B/CTSB/HLA-DQA2/HLA-DRA/CD74/HSP90AA1/LGMN/HLA-A/HLA-DPA1/HLA-DMB/HLA-DPB1/HLA-F/PSME2/HLA-DQA1/HLA-C/HLA-E/HLA-DMA/HSP90AB1/TAPBP/HLA-DQB1/CD4/IFI30/TAP1/CTSL/HLA-DRB1/CIITA/HLA-DOA/CANX/NFYC/HSPA6/HSPA4/HSPA8	10.7669331175413
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	54/837	181/9376	3.34200677241134	CTSD/HLA-DQA2/HLA-DRA/CD74/FCGR3A/HLA-DPA1/C3/HLA-DMB/ATP6V0B/HLA-DPB1/STAT1/IL18/ATP6V0D1/HLA-DQA1/FCGR1A/TNFRSF1A/LAMP2/ITGB2/HLA-DMA/CEBPB/IFNGR2/FCER1G/BAX/ATP6AP1/NFKB1/RHOA/HLA-DQB1/IL10RA/RAB5C/LAMP1/TCIRG1/IFNGR1/CYCS/RAB7A/IRAK1/TLR1/CARD9/VDR/PLK3/JAK2/SPHK1/ITGAX/TLR2/HSPA9/CAMK2D/HLA-DRB1/BID/ITGAM/CIITA/HLA-DOA/TRADD/NFYC/EEA1/IL10	9.96085063147814
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	34/837	95/9376	4.00910520027668	HLA-DQA2/ACP5/HLA-DRA/VEGFA/HLA-DPA1/HLA-DMB/ATP6V0B/HLA-DPB1/ATP6V1F/IL18/ATP6V0D1/HLA-DQA1/ITGB2/HLA-DMA/ATP6AP1/HLA-DQB1/JUN/TCIRG1/ICAM1/CCL5/ATP6V0E1/ATP6V1G1/ATP6V1A/ATP6V1C1/CCL20/ATP6V1D/CTSL/TLR2/HLA-DRB1/HLA-DOA/CXCL3/CXCL2/ATP6V1B2/CD80	9.22883003881888
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	30/837	78/9376	4.30842753423399	HLA-DQA2/HLA-DRA/FCGR3A/HLA-DPA1/C3/HLA-DMB/HLA-DPB1/STAT1/HLA-DQA1/FCGR1A/ITGB2/HLA-DMA/IFNGR2/NFKB1/CYBA/HLA-DQB1/JUN/NCF2/IFNGR1/NFKBIA/IRAK1/JAK2/PTPN6/MARCKSL1/TLR2/HLA-DRB1/ITGAM/HLA-DOA/CYBB/IL10	9.18584297907145
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	52/837	205/9376	2.84146050062651	B2M/HLA-B/HLA-DQA2/HLA-DRA/HLA-A/HLA-DPA1/VIM/HLA-DMB/HLA-DPB1/STAT1/HLA-F/HLA-DQA1/HLA-C/CD58/HLA-E/HLA-DMA/BAX/NFKBIE/NFKB1/TAPBP/HLA-DQB1/JUN/CD40/TAP1/GADD45B/ICAM1/CD44/CYCS/NFKBIA/BTK/IRAK1/RELB/CDKN1A/CXCL10/NCOR2/TNFAIP3/TLR2/RAC1/HLA-DRB1/BID/CDK6/HLA-DOA/NFKB2/PIK3R1/TRADD/RB1/STAT3/IFNAR1/USP7/TRAF3/SAP30/PSMD13	8.34595140921866
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	36/837	112/9376	3.60061443932412	HSPA1A/HSPA1B/HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DPB1/STAT1/HLA-DQA1/TNFRSF1A/LY96/HLA-DMA/IFNGR2/NFKB1/HLA-DQB1/IL10RA/CD40/IFNGR1/ALOX5/CYCS/NFKBIA/GNAI2/IRAK1/XIAP/PPIF/JAK2/TLR2/HLA-DRB1/CIITA/HLA-DOA/PIK3R5/HSPA6/STAT3/HSPA8/SOCS1/IL10	8.66823283169066
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	58/837	250/9376	2.59884348864994	HLA-B/HSPA1A/HSPA1B/CXCR4/CHMP1B/HLA-A/HLA-F/HLA-C/HLA-E/DAB2/WIPF1/RHOA/RAB5C/TGFBR1/ACTR3/AP2S1/AGAP3/RAB31/PDCD6IP/TFRC/CYTH1/ARPC4/TGFBR2/ARFGAP3/ZFYVE16/ARAP1/RAB7A/ARRB2/CHMP3/CAPZB/AP2M1/CAPZA2/IL2RG/SMAP1/RUFY1/GIT2/IST1/VPS37B/USP8/ARF6/SMURF2/ARF3/HSPA6/IGF2R/CHMP1A/SNX1/CAPZA1/VPS26A/VPS35/EEA1/CLTC/RAB8A/HSPA8/RABEP1/PSD3/VPS36/CHMP5/EHD4	8.0219617178378
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	26/837	70/9376	4.16071001877454	HLA-B/HLA-DQA2/HLA-DRA/HLA-A/HLA-DPA1/HLA-DMB/HLA-DPB1/HLA-F/HLA-DQA1/HLA-C/HLA-E/ITGB2/HLA-DMA/HLA-DQB1/CD40/ACTB/ICAM1/CYCS/ABL2/EIF4G2/RAC1/HLA-DRB1/BID/HLA-DOA/EIF4G3/CD80	8.30992318695974
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	45/837	180/9376	2.80047789725209	B2M/HLA-B/HLA-DQA2/HLA-DRA/CD74/HLA-A/HLA-DPA1/C3/HLA-DMB/HLA-DPB1/STAT1/HLA-F/HLA-DQA1/HLA-C/TNFRSF1A/HLA-E/HLA-DMA/IFNGR2/BAX/NFKB1/TAPBP/HLA-DQB1/TAP1/IFNGR1/TNFRSF14/CYCS/NFKBIA/CCL5/BST2/SP100/IRAK1/CARD9/RHEB/JAK2/TLR2/HLA-DRB1/BID/HLA-DOA/EIF4EBP1/PIK3R1/TRADD/PILRA/IFIH1/IFNAR1/TRAF3	7.6360616493981
Human Diseases	Immune disease	hsa05330	Allograft rejection	18/837	39/9376	5.17011304108078	HLA-B/HLA-DQA2/HLA-DRA/HLA-A/HLA-DPA1/HLA-DMB/HLA-DPB1/HLA-F/HLA-DQA1/HLA-C/HLA-E/HLA-DMA/HLA-DQB1/CD40/HLA-DRB1/HLA-DOA/IL10/CD80	8.16998599889777
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/837	142/9376	2.83992124791761	TREM2/ACP5/TYROBP/FCGR3A/STAT1/FCGR1A/TNFRSF1A/IFNGR2/SIRPA/FOSL2/NFKB1/CYBA/SPI1/LILRB4/JUN/SQSTM1/TGFBR1/NCF2/IFNGR1/MITF/ATP2A2/NFKBIA/TGFBR2/LCP2/BTK/RELB/CYLD/OSCAR/CSF1R/ITPR2/RAC1/NFKB2/PIK3R1/JUNB/IFNAR1/SOCS1	6.91661070157684
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	48/837	224/9376	2.40040962621608	B2M/HLA-B/HLA-DQA2/HLA-DRA/HLA-A/HLA-DPA1/HLA-DMB/HLA-DPB1/HLA-F/HLA-DQA1/HLA-C/ZFP36/TNFRSF1A/HLA-E/ITGB2/HLA-DMA/BAX/NFKB1/HLA-DQB1/SPI1/JUN/CD4/TGFBR1/CD40/ICAM1/NFKBIA/TGFBR2/STAT5A/KRAS/XIAP/RELB/CDKN1A/TLN1/TSPO/IL2RG/HLA-DRB1/HLA-DOA/NFKB2/EGR2/NRP1/PIK3R1/CANX/MAD1L1/RB1/NRAS/IL15RA/CREB3/ADCY7	6.64149654786179
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	30/837	109/9376	3.0830949327546	HLA-DQA2/HLA-DRA/HSP90AA1/HLA-DPA1/HLA-DMB/HLA-DPB1/STAT1/HLA-DQA1/HLA-DMA/HIF1A/IFNGR2/HSP90AB1/NFKBIE/NFKB1/HLA-DQB1/JUN/CD4/TGFBR1/IFNGR1/NFKBIA/TGFBR2/STAT5A/JAK2/RUNX1/IL2RG/HLA-DRB1/HLA-DOA/STAT3/AHR/IL6R	6.84853359261359
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	37/837	157/9376	2.63994094772809	LIPA/DUSP2/C1QB/CD36/HAVCR2/HIF1A/CEBPB/C1QA/SIRPA/ITGAV/C1QC/SGK1/ABCA1/ADAM9/RAB5C/NR1H3/PTGER4/PLA2G15/CD47/ATP2A2/ALOX5/TMEM30A/RAB7A/JAK2/MERTK/PTPN6/SPHK1/ADAM10/AXL/RAC1/CAMK2D/LRP1/GPR132/CPT1A/VPS41/RAB14/IL10	6.48755404887241
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	42/837	196/9376	2.40040962621608	HLA-B/VEGFA/HLA-A/C3/STAT1/HLA-F/CLEC2B/HLA-C/ZFP36/TNFRSF1A/HLA-E/HIF1A/BAX/NFKB1/JUN/GNB4/IFNGR1/ICAM1/CYCS/NFKBIA/KRAS/GNG5/CDKN1A/PREX1/JAK2/ITPR2/RAC1/BID/CDK6/PIK3R1/TRADD/PIK3R5/CTNNB1/CXCL3/RB1/STAT3/ATG3/BECN1/CXCL2/NRAS/IFNAR1/TRAF3	6.20306943991344
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	49/837	248/9376	2.21328091879601	HSP90AA1/IL18/TNFRSF1A/LY96/BAX/HSP90AB1/NFKB1/FLNA/RHOA/S100A10/M6PR/RHOB/ARL8B/JUN/PFN1/RAB5C/RALA/NCKAP1L/ARL8A/ACTR3/CYFIP1/ACTB/CYTH1/PLEKHM2/ARPC4/STX10/CYCS/NFKBIA/RAB7A/IRAK1/ABI1/KPNA4/RRAS/DYNC1I2/DYNC1LI1/ACTR10/TLR2/RHOG/RAC1/PYCARD/ARF6/TRADD/TNFRSF10B/CTNNB1/ACTR1A/DYNC1H1/ACBD3/VPS41/ANXA2	6.06239531978367
Human Diseases	Immune disease	hsa05310	Asthma	14/837	32/9376	4.90083632019116	HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DPB1/PRG2/HLA-DQA1/HLA-DMA/FCER1G/HLA-DQB1/CD40/HLA-DRB1/HLA-DOA/IL10	6.92008075111078
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	43/837	216/9376	2.23001017744148	OLR1/HSPA1A/HSPA1B/HSP90AA1/CD36/IL18/TNFRSF1A/LY96/BAX/HSP90AB1/NFKB1/CYBA/RHOA/ABCA1/JUN/RAP1A/CD40/NCF2/ICAM1/MMP9/CYCS/NFKBIA/CCL5/KRAS/IRAK1/JAK2/TLR2/RAC1/CAMK2D/BID/PYCARD/CYBB/PIK3R1/TNFRSF10B/HSPA6/CXCL3/HSPA4/STAT3/ABCG1/CXCL2/NRAS/HSPA8/TRAF3	5.72575424956277
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	37/837	173/9376	2.3957845594989	HLA-DQA2/HLA-DRA/DNAJB1/HLA-DPA1/HLA-DMB/HLA-DPB1/STAT1/IL18/HLA-DQA1/TNFRSF1A/HLA-DMA/IFNGR2/BAX/NFKB1/HLA-DQB1/ACTB/IFNGR1/ICAM1/CYCS/NFKBIA/CCL5/CXCL10/JAK2/DNAJC3/HLA-DRB1/BID/PYCARD/CIITA/CDK6/HLA-DOA/PIK3R1/TRADD/TNFRSF10B/HNRNPUL1/IFIH1/IFNAR1/TRAF3	5.8012501240915
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	18/837	54/9376	3.73397052966945	HLA-B/HLA-DQA2/HLA-DRA/HLA-A/HLA-DPA1/HLA-DMB/HLA-DPB1/HLA-F/HLA-DQA1/HLA-C/HLA-E/HLA-DMA/HLA-DQB1/CD40/HLA-DRB1/HLA-DOA/IL10/CD80	6.30784509930897
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	21/837	71/9376	3.31324145590388	ATP6V0B/ATP6V1F/ATP6V0D1/ATP6AP1/NFKB1/JUN/HBEGF/TCIRG1/NFKBIA/CCL5/ATP6V0E1/ATP6V1G1/ATP6V1A/ATP6V1C1/ATP6V1D/ADAM10/RAC1/CXCL3/CSK/CXCL2/ATP6V1B2	6.12543326631482
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/837	44/9376	4.07342239600304	HLA-B/HLA-DQA2/HLA-DRA/HLA-A/HLA-DPA1/HLA-DMB/HLA-DPB1/HLA-F/HLA-DQA1/HLA-C/HLA-E/HLA-DMA/HLA-DQB1/HLA-DRB1/HLA-DOA/CD80	6.39743799383749
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	44/837	227/9376	2.1712956383981	B2M/HLA-B/CXCR4/VEGFA/HLA-A/HLA-F/HLA-C/GNA13/TNFRSF1A/HLA-E/BAX/ITGAV/NFKB1/TAPBP/RHOA/IL10RA/GNB4/PTGER4/TAP1/CYCS/NFKBIA/CCL5/GNAI2/KRAS/GNG5/CDKN1A/RHEB/AKAP13/ITPR2/RAC1/BID/CDK6/EIF4EBP1/PIK3R1/TRADD/GNA12/CTNNB1/RB1/STAT3/NRAS/IL6R/GNAQ/CREB3/ADCY7	5.59290575668066
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	20/837	66/9376	3.39451866333587	HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DPB1/STAT1/IL18/HLA-DQA1/HLA-DMA/IFNGR2/NFKB1/HLA-DQB1/JUN/IFNGR1/IL2RG/TLR2/HLA-DRB1/HLA-DOA/STAT3/IL10	6.11167446977043
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/837	45/9376	3.98290189831408	HLA-B/HLA-DQA2/HLA-DRA/HLA-A/HLA-DPA1/HLA-DMB/HLA-DPB1/HLA-F/HLA-DQA1/HLA-C/HLA-E/HLA-DMA/HLA-DQB1/HLA-DRB1/HLA-DOA/CD80	6.27951342290386
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	25/837	99/9376	2.82876555277989	HLA-DQA2/HLA-DRA/FCGR3A/FPR3/HLA-DPA1/C3/HLA-DMB/HLA-DPB1/C1QB/HLA-DQA1/FCGR1A/ITGB2/HLA-DMA/C1QA/C1QC/HLA-DQB1/C5AR1/C2/C3AR1/ICAM1/PTAFR/HLA-DRB1/ITGAM/HLA-DOA/IL10	5.72686192055154
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	40/837	205/9376	2.18573884663578	HLA-B/HLA-A/C3/HLA-F/ATP6V0D1/REL/HLA-C/GSN/HLA-E/YWHAH/BAX/NFKB1/RHOA/JUN/NFKBIA/SP100/STAT5A/KRAS/CHD4/CDKN1A/UBR4/UBE3A/RAC1/PMAIP1/CDK6/NFKB2/EGR2/YWHAG/PIK3R1/TRADD/MRPS18B/TRAF1/MAD1L1/RB1/STAT3/NRAS/USP7/TRAF3/HDAC5/CREB3	5.37405977194638
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	16/837	50/9376	3.58461170848268	HLA-DQA2/CXCR4/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DPB1/HLA-DQA1/HLA-DMA/HLA-DQB1/CD40/ICOSLG/HLA-DRB1/HLA-DOA/IL10/IL15RA/CD80	5.73690243920785
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/837	93/9376	2.77036523169024	HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DMB/HLA-DPB1/STAT1/HLA-DQA1/HLA-DMA/IFNGR2/NFKBIE/NFKB1/HLA-DQB1/JUN/CD4/IFNGR1/NFKBIA/STAT5A/JAK2/IL2RG/MAML2/NOTCH2/HLA-DRB1/HLA-DOA	5.37161689773266
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	16/837	56/9376	3.2005461682881	HSPA1A/HSPA1B/C3/IL18/ITGB2/NFKB1/CYCS/NFKBIA/TLR2/PYCARD/ITGAM/NFKB2/HSPA6/CXCL3/CXCL2/HSPA8	5.17084360386692
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	31/837	160/9376	2.17037037037037	HLA-B/HLA-DQA2/HLA-DRA/HLA-A/HLA-DPA1/ALCAM/HLA-DMB/HLA-DPB1/HLA-F/HLA-DQA1/HLA-C/CD58/HLA-E/ITGB2/HLA-DMA/ITGAV/HLA-DQB1/CD4/CD40/ICAM1/SDC2/ICOSLG/SIGLEC1/HLA-DRB1/ITGAM/HLA-DOA/GLG1/SDC3/CD99/CADM1/CD80	4.67473435865356
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	19/837	78/9376	2.72867077168152	C3/C1QB/LY96/ITGB2/C1QA/NFKB1/C1QC/RHOA/JUN/C2/IRF1/GNAI2/IRF8/IRAK1/SERPING1/PYCARD/ITGAM/IL10/CFL1	4.79965122610835
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/837	42/9376	3.46725834897878	FTL/FTH1/HMOX1/GPX4/SLC3A2/ACSL3/TFRC/PRNP/SAT1/ATG7/CYBB/SLC11A2/PCBP1	5.017070855993
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	22/837	100/9376	2.46442054958184	HLA-DQA2/HLA-DRA/CD9/HLA-DPA1/HLA-DMB/HLA-DPB1/CD36/HLA-DQA1/FCGR1A/ANPEP/HLA-DMA/HLA-DQB1/CD4/CD44/TFRC/IL7R/CD38/CSF1R/HLA-DRB1/ITGAM/HLA-DOA/IL6R	4.60925043086914
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	37/837	214/9376	1.93677910651079	B2M/HLA-B/CXCR4/HLA-A/HLA-F/HLA-C/TNFRSF1A/HLA-E/BAX/NFKB1/TAPBP/JUN/CD4/GNB4/TAP1/SAMHD1/AP1B1/CYCS/NFKBIA/BST2/GNAI2/KRAS/IRAK1/GNG5/LIMK1/APOBEC3C/RNF7/ITPR2/TLR2/RAC1/BID/PIK3R1/TRADD/NRAS/APOBEC3G/CFL1/GNAQ	4.34004066988239
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/837	55/9376	3.05506679700228	PSAP/HEXB/HEXA/DEGS1/ASAH1/UGCG/GLB1/SPHK1/SGPL1/ACER3/SGMS1/CERS6/CERS2/ARSA/B4GALT5	4.78542918319228
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	27/837	137/9376	2.20767600659289	CTSD/CTSZ/CTSB/CTSH/TNFRSF1A/BAX/NFKB1/CTSC/JUN/LMNA/ACTB/GADD45B/CYCS/NFKBIA/KRAS/MCL1/XIAP/CTSL/ITPR2/PMAIP1/BID/PIK3R1/TRADD/TNFRSF10B/TRAF1/NRAS/PARP4	4.45803114771459
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	51/837	333/9376	1.71560808119948	SPP1/HLA-B/FN1/VEGFA/HLA-A/ATP6V0B/STAT1/ATP6V1F/HLA-F/ATP6V0D1/HLA-C/TNFRSF1A/HLA-E/BAX/ITGAV/ATP6AP1/NFKB1/PTGER4/TCIRG1/IRF1/ATP6V0E1/ATP6V1G1/ATP6V1A/KRAS/CHD4/CDKN1A/RHEB/ATP6V1C1/UBR4/UBE3A/ATP6V1D/OASL/MAML2/NOTCH2/CDK6/EIF4EBP1/PIK3R1/TRADD/CTNNB1/MFNG/BCAP31/PPP2R3C/RB1/PPP2CA/APC/NRAS/IFNAR1/ATP6V1B2/PSEN1/TRAF3/CREB3	4.16280385491132
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	22/837	103/9376	2.39264131027363	C3/C1QB/TNFRSF1A/IFNGR2/C1QA/NFKB1/C1QC/JUN/SERPINE1/TGFBR1/IFNGR1/NFKBIA/CCL5/TGFBR2/GNAI2/IRAK1/TLR2/PIK3R1/GNA15/PPP2CA/IL10/GNAQ	4.44930949575888
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	25/837	125/9376	2.24038231780167	CTSD/GNA13/TNFRSF1A/FCER1G/BAX/NFKB1/RHOA/DEGS1/ASAH1/GNAI2/KRAS/SPHK1/SGPL1/RAC1/BID/PIK3R1/TRADD/SGMS1/GNA12/CERS6/PPP2R3C/PPP2CA/NRAS/CERS2/GNAQ	4.37080159606317
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	24/837	119/9376	2.25920905996807	TNFRSF1A/CEBPB/NFKB1/JUN/MAP3K8/ICAM1/MMP9/IRF1/NFKBIA/CCL5/XIAP/RHBDF2/CXCL10/CYLD/CCL20/TNFAIP3/PIK3R1/TRADD/TRAF1/CXCL3/JUNB/CXCL2/TRAF3/CREB3	4.32793818302217
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	27/837	142/9376	2.12994093593821	DUSP1/HSP90AA1/VEGFA/HMOX1/TNFRSF1A/HSP90AB1/ITGAV/NFKB1/CYBA/RHOA/GSTO1/JUN/SQSTM1/MEF2A/NCF2/ACTB/MGST2/ICAM1/MMP9/SDC2/SUMO3/CTSL/RAC1/PIK3R1/CTNNB1/SUMO1/ARHGEF2	4.24766091402295
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	14/837	52/9376	3.01589927396379	APOE/APOC1/NPC2/LIPA/NCEH1/CD36/CYP27A1/ABCA1/PLTP/LPL/SOAT1/TSPO/LRP1/APOC2	4.56366995063183
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	30/837	168/9376	2.00034135518006	FTL/FTH1/GLUL/CHMP1B/HSP90AA1/STAT1/TNFRSF1A/IFNGR2/BAX/HSP90AB1/SQSTM1/IFNGR1/STAT5A/XIAP/CHMP3/JAK2/CYLD/SHARPIN/GLUD1/TNFAIP3/CAMK2D/BID/PYCARD/CYBB/TRADD/TNFRSF10B/CHMP1A/STAT3/IFNAR1/CHMP5	4.0960483019775
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	34/837	200/9376	1.90432497013142	IL18/GNA13/TNFRSF1A/BAX/NFKB1/WIPF1/RHOA/JUN/NCKAP1L/ACTR3/CYFIP1/ACTB/CYTH1/ARPC4/CYCS/NFKBIA/IRAK1/ABI1/MYO5A/NCK1/PTPN6/MYO1F/RAC1/PYCARD/TMED10/ARF6/TRADD/MYO1E/GNA12/TNFRSF10B/LPAR5/ARHGEF2/TMBIM6/HCLS1	4.04722806998086
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	19/837	88/9376	2.41859454762681	C3/A2M/C1QB/ITGB2/C1QA/C1QC/SERPINE1/C5AR1/PLAUR/C2/SERPINE2/C3AR1/SERPINA1/VSIG4/ITGAX/SERPING1/PLAU/ITGAM/CD46	4.18584728296513
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/837	105/9376	2.24038231780167	TNFRSF1A/LY96/NFKB1/CD40/GADD45B/ICAM1/NFKBIA/BTK/IRAK1/XIAP/RELB/CYLD/TNFAIP3/PLAU/UBE2I/NFKB2/TRADD/TRAF1/CXCL3/CXCL2/TRAF3	4.00158260007241
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	21/837	105/9376	2.24038231780167	STAT1/FCER1G/NFKB1/RHOA/JUN/MRAS/IRF1/NFKBIA/KRAS/RELB/CARD9/RRAS/PLK3/CYLD/ITPR2/PYCARD/NFKB2/EGR2/PIK3R1/NRAS/IL10	4.00158260007241
Human Diseases	Infectious disease: viral	hsa05162	Measles	25/837	136/9376	2.05917492445007	HSPA1A/HSPA1B/STAT1/BAX/NFKB1/JUN/CYCS/NFKBIA/STAT5A/IRAK1/IL2RG/TNFAIP3/TLR2/BID/CDK6/MSN/PIK3R1/TRADD/HSPA6/STAT3/IFIH1/IFNAR1/CD46/HSPA8/TRAF3	3.89534582050753
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/837	51/9376	2.85538922857076	ATP6V0B/ATP6V1F/ATP6V0D1/ATP6AP1/TCIRG1/ACTB/ATP6V0E1/ATP6V1G1/ATP6V1A/ATP6V1C1/ATP6V1D/ATP6V1B2/SEC61A1	4.15949454625943
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	29/837	169/9376	1.92222151527362	CTSD/CTSB/VAMP8/LAMP2/HIF1A/GABARAP/GABARAPL1/SQSTM1/LAMP1/STX7/MRAS/RAB7A/KRAS/RHEB/RRAS/CTSL/ATG7/RRAGD/PIK3R1/DAPK1/DDIT4/TAX1BP1/PPP2CA/ATG3/BECN1/NRAS/VPS41/ATG4B/RAB8A	3.78760247063682
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	25/837	138/9376	2.02933180960296	FN1/IL18/NFKB1/WIPF1/RHOA/SKAP2/JUN/CD4/ACTR3/ACTB/ARPC4/NFKBIA/LCP2/IRAK1/LIMK1/RPS6KA1/RHOG/RAC1/GIT2/PYCARD/PIK3R1/ARF6/IL10/WAS/GNAQ	3.81373768896847
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/837	28/9376	3.60061443932412	ATP6V1F/ATP6V0D1/TCIRG1/ATP6V0E1/ATP6V1G1/ATP6V1A/ATP6V1C1/ATP6V1D/ATP6V1B2	4.31459954929116
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	31/837	187/9376	1.85700138641315	CTSB/HSP90AA1/TXNIP/STAT1/IL18/GBP5/HSP90AB1/GABARAP/NFKB1/CYBA/RHOA/GABARAPL1/JUN/GBP1/GBP4/NFKBIA/CCL5/GBP2/XIAP/CARD9/SHARPIN/ITPR2/TNFAIP3/P2RX7/PYCARD/CYBB/GBP3/CXCL3/CXCL2/IFNAR1/TRAF3	3.70606525912051
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	33/837	204/9376	1.81207393351606	FN1/VEGFA/TIMP3/HIF1A/ITGAV/FLNA/RHOA/CD63/HBEGF/PLAUR/MRAS/ACTB/CD44/MMP9/SDC2/KRAS/CDKN1A/RRAS/PTPN6/CTSL/ITPR2/TLR2/HGF/RAC1/CAMK2D/PLAU/MSN/PIK3R1/CTNNB1/DDX5/STAT3/NRAS/HCLS1	3.67133057849088
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/837	87/9376	2.31763688048449	BAX/RHOA/JUN/TGFBR1/RALA/GADD45B/CYCS/TGFBR2/KRAS/CDKN1A/AREG/RALGDS/RAC1/PMAIP1/PIK3R1/CTNNB1/APC/NRAS	3.86558962925893
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/837	174/9376	1.86698526483473	HSPA1A/HSPA1B/HSP90AA1/DNAJB1/HSPH1/BAX/HSP90AB1/HERPUD1/UBE2D3/OS9/SEL1L/STUB1/MAN1A1/UBE2G2/RPN1/DNAJB11/DERL1/DNAJC3/TRAM1/CANX/SSR1/HSPA6/BCAP31/UBXN6/BCAP29/DNAJA2/HSPA8/DNAJA1/SEC61A1	3.61401612883633
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	7/837	19/9376	4.12702005910834	HEXB/HEXA/GNS/IDS/GLB1/ARSB/NAGLU	4.27153543356487
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	16/837	77/9376	2.32766994057317	VEGFA/STAT1/BAX/NFKB1/TGFBR1/RALA/GADD45B/TGFBR2/KRAS/CDKN1A/RALGDS/RAC1/CDK6/PIK3R1/RB1/STAT3	3.6623700329747
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	43/837	300/9376	1.60560732775787	HSPA1A/HSPA1B/DUSP1/VEGFA/DUSP2/MAP3K2/TNFRSF1A/HSPB1/NFKB1/FLNA/JUN/RAP1A/MAP3K8/TGFBR1/MRAS/VEGFB/GADD45B/RASGRP3/TGFBR2/MAX/KRAS/ARRB2/IRAK1/STK4/RELB/RRAS/DUSP10/PTPN7/AREG/DUSP3/CSF1R/RPS6KA1/HGF/RAC1/NFKB2/TRADD/GNA12/HSPA6/NRAS/HSPA8/TAOK3/RAPGEF2/LAMTOR3	3.33771588458027
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/837	101/9376	2.10729029892237	FN1/VEGFA/STAT1/BAX/NFKB1/JUN/SERPINE1/TGFBR1/VEGFB/ICAM1/TGFBR2/STAT5A/KRAS/JAK2/RAC1/CYBB/PIK3R1/STAT3/NRAS	3.50275759322494
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	20/837	109/9376	2.0553966218364	SPP1/STAT1/LY96/CXCL9/NFKB1/JUN/MAP3K8/CD40/NFKBIA/CCL5/IRAK1/TLR1/CXCL10/CXCL11/TLR2/RAC1/PIK3R1/IFNAR1/TRAF3/CD80	3.46979828164604
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	26/837	157/9376	1.85509363894406	HLA-B/HLA-A/HLA-F/HLA-C/HLA-E/NFKB1/SQSTM1/SERPINE1/TGFBR1/MRAS/GADD45B/TGFBR2/KRAS/NBN/CDKN1A/RHEB/RRAS/ITPR2/CDK6/EIF4EBP1/HIPK2/PIK3R1/ZFP36L1/RB1/NRAS/RASSF5	3.38272314450215
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	26/837	158/9376	1.8433525399634	ATP6V1F/TNFRSF1A/SGK1/RHOA/SLC3A2/LAMTOR2/MAPKAP1/ATP6V1G1/ATP6V1A/KRAS/FNIP1/RHEB/ATP6V1C1/LPIN2/ATP6V1D/RPS6KA1/SLC7A5/EIF4EBP1/RRAGD/PIK3R1/DDIT4/NRAS/ATP6V1B2/SESN2/LAMTOR3/CAB39	3.34706548411471
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	30/837	193/9376	1.74122978067488	CXCR4/STAT1/CXCL16/CXCL9/NFKB1/RHOA/RAP1A/GNB4/NFKBIA/CCL5/GNAI2/KRAS/ARRB2/GNG5/CXCL10/PREX1/JAK2/CCL20/CCL18/CXCL11/RAC1/PIK3R1/PIK3R5/CXCL3/STAT3/CXCL2/NRAS/WAS/GNAQ/ADCY7	3.2574974362217
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	24/837	144/9376	1.86698526483473	C3/C1QB/TNFRSF1A/LY96/C1QA/NFKB1/C1QC/ALDH2/C5AR1/C2/C3AR1/ACADVL/NFKBIA/IRAK1/PRKAG2/LPIN2/TRADD/CTNNB1/CXCL3/CPT1A/ALDH3A2/CXCL2/ADIPOR2/TRAF3	3.28238806539722
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	32/837	212/9376	1.69085457947296	VEGFA/APBB1IP/ITGB2/RHOA/DOCK4/RAP1A/PFN1/RALA/MRAS/VEGFB/ACTB/RASGRP3/LCP2/GNAI2/KRAS/VASP/TLN1/RRAS/RALGDS/CSF1R/HGF/RAC1/RAPGEF1/ITGAM/PIK3R1/CTNNB1/LPAR5/NRAS/RAPGEF2/RASSF5/GNAQ/ADCY7	3.18534803914076
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	17/837	90/9376	2.11591663347936	STAT1/HIF1A/IFNGR2/NFKBIE/NFKB1/JUN/CD4/IFNGR1/NFKBIA/KRAS/JAK2/PTPN6/TLR2/PIK3R1/EML4/STAT3/NRAS	3.33030129730643
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/837	61/9376	2.38729263372309	FTL/FTH1/ATP1B3/ATOX1/HMOX1/SLC8A1/ATP1B1/SLC31A1/MT1X/VDR/ATP2B1/SLC30A1/SLC11A2	3.4031918190978
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/837	163/9376	1.78680798352281	STAT1/BAX/ATP6AP1/NFKB1/JUN/TGFBR1/MMP9/CYCS/NFKBIA/TGFBR2/STAT5A/KRAS/IRAK1/CDKN1A/JAK2/TLR2/BID/EGR2/PIK3R1/RB1/STAT3/NRAS/IFIH1/IFNAR1/TRAF3/CREB3	3.17253838196259
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	25/837	156/9376	1.79517813926416	CD81/STAT1/TNFRSF1A/YWHAH/BAX/NFKB1/NR1H3/CYCS/NFKBIA/KRAS/CDKN1A/CXCL10/BID/CDK6/YWHAG/PIK3R1/TRADD/CTNNB1/RB1/STAT3/PPP2CA/PIAS1/NRAS/IFNAR1/TRAF3	3.13549513425996
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	18/837	100/9376	2.01634408602151	CXCR4/IL18/TNFRSF1A/CXCL9/IL10RA/TNFRSF14/CCL5/CXCL10/CCL20/IL2RG/CSF1R/CCL18/CXCL11/TNFRSF10B/CXCL3/CXCL2/IL10/IL6R	3.19893381566081
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	22/837	133/9376	1.85294778164048	HLA-B/TYROBP/FCGR3A/HLA-A/HLA-C/HLA-E/ITGB2/IFNGR2/FCER1G/IFNGR1/ICAM1/LCP2/KRAS/SH3BP2/LAT2/PTPN6/RAC1/BID/PIK3R1/TNFRSF10B/NRAS/IFNAR1	3.10160614473088
Organismal Systems	Immune system	hsa04611	Platelet activation	21/837	126/9376	1.86698526483473	VAMP8/APBB1IP/GNA13/FCER1G/RHOA/FERMT3/RAP1A/ACTB/LCP2/GNAI2/BTK/VASP/TLN1/ITPR2/PTGS1/SNAP23/PIK3R1/PIK3R5/TBXAS1/GNAQ/ADCY7	3.06740402374178
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	15/837	79/9376	2.12694523841931	ATP6V0B/ATP6V1F/ATP6V0D1/TCIRG1/AP2S1/SLC1A3/ATP6V0E1/ATP6V1G1/ATP6V1A/NAPA/ATP6V1C1/AP2M1/ATP6V1D/CLTC/ATP6V1B2	3.14912430260482
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/837	50/9376	2.46442054958184	CD81/CD36/IL18/ITGB2/CD40/ICAM1/SDC2/TLR2/HGF/LRP1/IL10	3.25048354278879
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/837	73/9376	2.14831181159064	BAX/GADD45B/STAT5A/KRAS/STK4/CDKN1A/HGF/CDK6/PIK3R1/EML4/RB1/STAT3/NRAS/RASSF5	3.08357568189596
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	35/837	253/9376	1.54967156369681	C3/IL18/TNFRSF1A/BAX/NFKB1/RHOA/UBE2D3/JUN/SQSTM1/PFN1/ACTR3/ACTB/CD44/CYTH1/ARPC4/CYCS/NFKBIA/CCL5/TLN1/SHARPIN/TNIP1/ITPR2/RAC1/CAPNS1/PYCARD/RRAGD/PIK3R1/ARF6/TRADD/ILK/BECN1/ARHGEF2/FNBP1/HCLS1/HK1	2.77485026965488
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/837	68/9376	2.14154192142807	FCGR1A/NFKB1/SPI1/CEBPA/STAT5A/KRAS/RUNX1/CSF1R/ITGAM/EIF4EBP1/PIK3R1/STAT3/NRAS	2.95776042936809
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	14/837	76/9376	2.06351002955417	OLR1/FABP5/CD36/CYP27A1/PLIN2/PLTP/LPL/NR1H3/DBI/ACSL3/GK/SLC27A1/ILK/CPT1A	2.91441754150185
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	19/837	116/9376	1.83479586371689	CXCR4/ITGB2/CYBA/RHOA/RAP1A/NCF2/ACTB/ICAM1/MMP9/GNAI2/VASP/RAC1/ITGAM/MSN/CYBB/PIK3R1/CTNNB1/CD99/RASSF5	2.83236128995911
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/837	77/9376	2.03671119800152	BAX/NFKB1/TGFBR1/GADD45B/NFKBIA/TGFBR2/STAT5A/KRAS/CDKN1A/RUNX1/CDK6/PIK3R1/RB1/NRAS	2.85976198479793
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/837	15/9376	3.73397052966945	HEXB/HEXA/GLB1/B3GALT4/ST6GALNAC4	3.31759368883575
NA	NA	hsa03272	Virion - Hepatitis viruses	10/837	48/9376	2.33373158104341	CD81/CHMP1B/CD9/LAMP2/CD63/TGOLN2/LAMP1/PDCD6IP/IST1/CHMP1A	2.90027811322323
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/837	41/9376	2.45895620246525	VEGFA/TYMP/HBEGF/MMP9/KRAS/CDKN1A/DAPK1/RB1/NRAS	2.9310409245592
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	19/837	120/9376	1.77363600159299	BAX/NFKBIE/NFKB1/RHOA/JUN/RAP1A/NFKBIA/KRAS/IRAK1/RPS6KA1/RAC1/CAMK2D/RAPGEF1/KIDINS220/PIK3R1/SH2B3/ARHGDIA/NRAS/PSEN1	2.6703026217667
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/837	22/9376	3.05506679700228	AOC1/ALDH2/HNMT/CNDP2/ALDH3B1/ALDH3A2	3.02122771913335
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/837	105/9376	1.81364282869659	HIF1A/GABARAP/GABARAPL1/JUN/SQSTM1/RAB5C/MRAS/MITF/RAB7A/KRAS/RRAS/ARIH1/USP8/SMURF2/TAX1BP1/BECN1/NRAS	2.62488342445605
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/837	140/9376	1.68028673835125	SPP1/GNA13/SLC8A1/SERPINE1/GNB4/TGFBR1/MEF2A/MRAS/GNAI2/KRAS/GNG5/RRAS/PRKAG2/SPHK1/ITPR2/PIK3R5/BECN1/NRAS/HDAC5/GNAQ/ADCY7	2.53897790168019
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/837	75/9376	1.94166467542812	BAX/SERPINE1/CD82/GADD45B/CYCS/CDKN1A/ZNF385A/PMAIP1/BID/CDK6/TNFRSF10B/SESN2/TP53I3	2.56334433478928
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	31/837	232/9376	1.49680715197957	FN1/TMSB4X/CXCR4/GSN/GNA13/ITGB2/ITGAV/RGCC/RHOA/PFN1/MRAS/NCKAP1L/ACTR3/CYFIP1/ACTB/ARPC4/KRAS/SSH1/RRAS/LIMK1/ITGAX/RAC1/ITGAM/MSN/PIK3R1/GNA12/LPAR5/APC/NRAS/PIP4K2A/CFL1	2.39888033025206
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/837	93/9376	1.80675993371103	FN1/BAX/ITGAV/NFKB1/GADD45B/CYCS/NFKBIA/MAX/XIAP/CDKN1A/CDK6/PIK3R1/TRAF1/RB1/TRAF3	2.44785946694082
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/837	110/9376	1.73120451830129	VEGFA/HMOX1/HIF1A/IFNGR2/NFKB1/SERPINE1/IFNGR1/TFRC/CDKN1A/CAMK2D/EIF4EBP1/CYBB/PIK3R1/STAT3/IL6R/HK1/PFKFB3	2.41509334625939
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/837	18/9376	3.11164210805788	HEXB/HEXA/MANBA/GLB1/FUCA2	2.80743626875363
NA	NA	hsa04518	Integrin signaling	22/837	154/9376	1.60027308414405	SPP1/FN1/VEGFA/C3/LIMS1/ITGB2/ITGAV/FLNA/FERMT3/VEGFB/ACTB/ICAM1/PARVB/TLN1/ITGAX/FBN1/HGF/RAC1/ITGAM/PIK3R1/CTNNB1/ILK	2.35148131519622
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	15/837	94/9376	1.7875390833524	HSP90AA1/CEBPB/HSP90AB1/NFKB1/JUN/MMP9/NFKBIA/CXCL10/CCL20/TNFAIP3/TRADD/CXCL3/CXCL2/TRAF3/USP25	2.40248188094752
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/837	78/9376	1.86698526483473	FN1/RHOA/ACTR3/ACTB/ARPC4/RHOG/RAC1/PIK3R1/CTNNB1/ILK/CLTC/ARHGAP10/HCLS1	2.40718299721938
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/837	70/9376	1.92032770097286	CD36/TNFRSF1A/NFKBIE/NFKB1/ACSL3/NFKBIA/PRKAG2/JAK2/TRADD/CPT1A/STAT3/ADIPOR2	2.41966281515473
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/837	32/9376	2.45041816009558	GABARAP/GABARAPL1/ATG7/PPP2CA/ATG3/BECN1/ATG4B	2.57304074482343
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/837	32/9376	2.45041816009558	TNFRSF1A/BAX/CYCS/XIAP/PMAIP1/BID/BECN1	2.57304074482343
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	22/837	157/9376	1.56969461756805	TNFRSF1A/BAX/NFKB1/JUN/CEBPA/NR1H3/CYCS/PRKAG2/NDUFA13/SDHD/RAC1/BID/SDHB/COX8A/PIK3R1/NDUFB5/COX6A1/MLX/ADIPOR2/NDUFB2/MLXIP/IL6R	2.25369372473114
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/837	149/9376	1.57879290851796	GNA13/FCER1G/RHOA/RALA/MRAS/CYTH1/KRAS/AGPAT2/RHEB/RRAS/SPHK1/RALGDS/LPAR6/PIK3R1/ARF6/PIK3R5/GNA12/AGPAT3/LPAR5/NRAS/ADCY7	2.22962043296405
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/837	33/9376	2.37616306433511	VAMP8/STX4/STX6/STX7/VTI1B/SNAP23/VAMP5	2.47929699093563
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	23/837	168/9376	1.53359503897138	CSH1/STAT1/CSH2/IFNGR2/IL10RA/IL13RA1/IFNGR1/OSM/STAT5A/MCL1/CDKN1A/JAK2/IL7R/PTPN6/IL2RG/PIK3R1/STAT3/PIAS1/IFNAR1/SOCS1/IL10/IL6R/IL15RA	2.18488523143075
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/837	98/9376	1.71457830444006	FCGR3A/GSN/FCGR1A/MARCKS/ACTR3/ARPC4/VASP/LIMK1/SPHK1/MARCKSL1/RAC1/PIK3R1/ARF6/CFL1/WAS	2.22628387373986
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/837	133/9376	1.60027308414405	GABARAP/SGK1/GABARAPL1/TGFBR1/HOMER3/GADD45B/SGK3/TGFBR2/KRAS/STK4/CDKN1A/PLK3/PRKAG2/IL7R/PIK3R1/STAT3/NRAS/USP7/IL10	2.18279562521039
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/837	73/9376	1.84141012422055	CXCR4/ELL2/RANBP2/CD4/MDFIC/SAMHD1/PDCD6IP/BST2/APOBEC3C/AFF4/SUPT4H1/APOBEC3G	2.25944884600079
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/837	143/9376	1.56670092153963	HLA-DQA2/HLA-DRA/FCGR3A/HLA-DPA1/C3/HLA-DMB/HLA-DPB1/C1QB/HLA-DQA1/FCGR1A/HLA-DMA/C1QA/C1QC/HLA-DQB1/C2/CD40/HLA-DRB1/HLA-DOA/IL10/CD80	2.13793934728388
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/837	91/9376	1.72337101369359	CD81/NFKBIE/NFKB1/CD72/LILRB4/JUN/RASGRP3/NFKBIA/BTK/KRAS/PTPN6/RAC1/PIK3R1/NRAS	2.1708794354963
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	43/837	362/9376	1.33061380753414	SPP1/FN1/CSH1/HSP90AA1/VEGFA/CSH2/YWHAH/HSP90AB1/ITGAV/NFKB1/SGK1/GNB4/VEGFB/SGK3/OSM/KRAS/MCL1/GNG5/CDKN1A/RHEB/JAK2/IL7R/AREG/IL2RG/CSF1R/TLR2/HGF/RAC1/CDK6/LPAR6/EIF4EBP1/YWHAG/PIK3R1/PIK3R5/PPP2R3C/DDIT4/LPAR5/PPP2CA/NRAS/IFNAR1/IL6R/CREB3/CDC37	2.00845153304816
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/837	43/9376	2.08407657469923	ACAA2/ALDH2/ACADVL/ACSL3/HADHB/CPT1A/ALDH3A2/HADHA	2.23063450226149
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	26/837	201/9376	1.44900348912546	ID2/NR4A3/REL/FCGR1A/CEBPB/BAX/NFKB1/SPI1/BMP2K/JMJD1C/CEBPA/CD40/PBX3/GADD45B/MMP9/MITF/TGFBR2/ETV6/MAX/CDKN1A/RUNX1/CSF1R/PLAU/ITGAM/TRAF1/DDX5	2.01460342756807
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	19/837	138/9376	1.54229217529825	ATP6V0B/ATP6V1F/ATP6V0D1/ATP6AP1/TCIRG1/CYCS/ATP6V0E1/ATP6V1G1/ATP6V1A/ATP6V1C1/ATP6V1D/NDUFA13/SDHD/SDHB/COX8A/NDUFB5/COX6A1/NDUFB2/ATP6V1B2	2.00922587650855
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/837	130/9376	1.55103391232423	VEGFA/NFKB1/JUN/GNB4/TGFBR1/VEGFB/MMP9/NFKBIA/TGFBR2/GNAI2/KRAS/ARRB2/GNG5/PIK3R1/GNA15/NRAS/CREB3/ADCY7	1.98069643321342
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/837	53/9376	1.90221140190708	ATP1B3/SLC8A1/ATP1B1/AP2S1/VDR/AP2M1/ATP2B1/CLTC/GNAQ	2.06211681880197
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/837	70/9376	1.76030039255846	VEGFA/HIF1A/JUN/RAP1A/KRAS/CDKN1A/HGF/RAC1/RAPGEF1/PIK3R1/NRAS	1.99892993145437
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/837	62/9376	1.80675993371103	ATXN1/APH1A/NCOR2/MAML2/NOTCH2/MFNG/SPEN/APH1B/NUMB/PSEN1	1.99534000537825
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/837	38/9376	2.06351002955417	HEXB/GNPDA1/HEXA/RENBP/AMDHD2/UAP1/HK1	2.05660701983184
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/837	38/9376	2.06351002955417	CD4/CD40/TAP1/BTK/IL7R/IL2RG/CIITA	2.05660701983184
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/837	115/9376	1.55852682977508	GNA13/SGK1/RHOA/NR4A2/HBEGF/MEF2A/GNAI2/ARRB2/CDKN1A/VDR/AKAP13/ITPR2/GNA12/GNAQ/CREB3/ADCY7	1.8867261921683
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	35/837	298/9376	1.3156607570983	CSH1/CXCR4/CSH2/IL18/CXCL16/TNFRSF1A/CXCL9/IFNGR2/CD4/IL10RA/TGFBR1/CD40/IL13RA1/IFNGR1/OSM/TNFRSF14/CCL5/TGFBR2/TNFSF12/CXCL10/CCL20/IL7R/RELT/IL2RG/CSF1R/CCL18/CXCL11/IL32/TNFRSF10B/CXCL3/CXCL2/IFNAR1/IL10/IL6R/IL15RA	1.7337181552144
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/837	17/9376	2.63574390329609	NRP2/LAMP2/LAMP1/TFRC	2.11334260133107
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/837	109/9376	1.5415474663773	CD36/TNFRSF1A/NFKB1/NR1H3/NFKBIA/PTPN1/PRKAG2/RPS6KA1/SLC27A1/PIK3R1/CPT1A/STAT3/MLX/MLXIP/CREB3	1.78043062616226
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/837	57/9376	1.768722882475	PPT1/ACAA2/ACADVL/ACSL3/HSD17B4/ELOVL1/HADHB/CPT1A/HADHA	1.82249959817737
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/837	75/9376	1.64294703305456	BAX/GSTO1/MGST2/SLC31A1/CYCS/ERCC1/XIAP/CDKN1A/PMAIP1/BID/PIK3R1	1.75019269359414
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/837	139/9376	1.45060725613058	CTSD/HSPA1A/HSPA1B/HSP90AA1/HSP90AB1/JUN/HBEGF/MMP9/GNAI2/KRAS/ITPR2/PIK3R1/HSPA6/NRAS/HSPA8/GNAQ/CREB3/ADCY7	1.67565640003408
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/837	103/9376	1.52258992471958	FN1/ITGB2/HSPB1/NFKB1/RAB5C/RAB7A/TLR2/ITGAM/PIK3R1/CXCL3/GNA15/CXCL2/IL10/GNAQ	1.66960745548034
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/837	217/9376	1.34216452218533	HSP90AA1/VEGFA/HSP90AB1/NFKB1/KLF4/GSTO1/JUN/MGST2/GNAI2/STAT5A/KRAS/ARRB2/XIAP/KPNA4/VDR/JAK2/RPS6KA1/NOTCH2/EIF4EBP1/PIK3R1/RB1/STAT3/AHR/NRAS/CREB3/ADCY7	1.59656158304032
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	27/837	227/9376	1.3323859599261	VEGFA/HMOX1/AKR1A1/HIF1A/NFKB1/CYBA/GSTO1/JUN/NCF2/MGST2/NFKBIA/ABL2/KRAS/PPIF/PTPN1/NDUFA13/SDHD/HGF/RAC1/SDHB/COX8A/PIK3R1/NDUFB5/COX6A1/AHR/NDUFB2/NRAS	1.5871341852284
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/837	122/9376	1.46910315921421	NFKBIE/NFKB1/RHOA/JUN/CD4/MAP3K8/NFKBIA/LCP2/KRAS/NCK1/PTPN6/PIK3R1/PPP2R3C/PPP2CA/NRAS/IL10	1.6327826839016
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	16/837	122/9376	1.46910315921421	CSH1/STAT1/CSH2/GNAI2/STAT5A/KRAS/JAK2/ITPR2/PIK3R1/STAT3/JUNB/NRAS/SOCS1/GNAQ/CREB3/ADCY7	1.6327826839016
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/837	59/9376	1.7087661745945	BAX/GADD45B/KRAS/CDKN1A/PIK3R1/CTNNB1/ILK/APC/NRAS	1.70976255480633
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/837	86/9376	1.56305743102442	JUN/HBEGF/ABL2/STAT5A/KRAS/CDKN1A/NCK1/AREG/CAMK2D/EIF4EBP1/PIK3R1/NRAS	1.64224868787887
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/837	44/9376	1.78212229825133	STX4/RAB5C/DYNC1I2/DYNC1LI1/DYNC1H1/ARHGDIA/CREB3	1.62801537242901
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/837	20/9376	2.24038231780167	NPL/CYB5R4/NANS/UAP1	1.73848247961233
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/837	80/9376	1.54026284348865	VEGFA/BAX/KRAS/JAK2/AXL/HGF/EIF4EBP1/PIK3R1/STAT3/NRAS/IL6R	1.51931174938204
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/837	62/9376	1.62608394033992	HSPA1A/HSPA1B/KRAS/PRKAG2/PIK3R1/HSPA6/NRAS/HSPA8/ADCY7	1.54847840191896
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/837	71/9376	1.5777340266209	STAT1/NFKB1/IRF1/STAT5A/KRAS/JAK2/PIK3R1/STAT3/NRAS/SOCS1	1.52983218276402
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/837	28/9376	2.00034135518006	PPT1/ACAA2/ELOVL1/HADHB/HADHA	1.65963562107997
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/837	90/9376	1.49358821186778	BAX/NFKB1/KRAS/RHEB/PRKAG2/EIF4EBP1/PIK3R1/ADIPOR2/NRAS/SESN2/CREB3/ADCY7	1.4730468325337
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/837	37/9376	1.81652620362298	BAX/GADD45B/KRAS/CDKN1A/CTNNB1/NRAS	1.55799357102104
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/837	110/9376	1.42569783860106	ID2/SKIL/HAMP/RHOA/TGFBR1/TGIF1/SMAD7/TFRC/TGFBR2/EMP3/ZFYVE16/FBN1/SMURF2/PPP2CA	1.40603619341806
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/837	73/9376	1.53450843685046	BAX/GADD45B/MITF/KRAS/CDKN1A/HGF/CDK6/PIK3R1/RB1/NRAS	1.43532201010561
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/837	83/9376	1.48459069251918	DNASE2/IL18/NFKB1/SAMHD1/NFKBIA/CCL5/CXCL10/G3BP1/PYCARD/PCBP1/POLR3GL	1.38829259269591
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/837	102/9376	1.42769461428538	ATP1B3/RHOA/RAP1A/ATP1B1/ATP2A2/CD38/ATP2B1/ITPR2/RAC1/SLC4A2/RAB8A/GNAQ/ADCY7	1.35970652602754
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/837	65/9376	1.55103391232423	AKR1A1/ALDH2/LPL/AGPAT2/GK/LPIN2/AGPAT3/ALDH3A2/MGLL	1.39566665618477
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/837	93/9376	1.44540794696882	RHOA/RAP1A/TGFBR1/ACTB/TGFBR2/PTPN1/PTPN6/PDCD10/RAC1/SMURF2/CTNNB1/WAS	1.35145043039388
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/837	122/9376	1.37728421176332	FBP1/CD36/RHEB/PRKAG2/EIF4EBP1/PIK3R1/PPP2R3C/CPT1A/PPP2CA/ADIPOR2/RAB8A/RAB14/CAB39/CREB3/PFKFB3	1.31319330466354
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/837	122/9376	1.37728421176332	STAT1/ATP1B3/HIF1A/ITGAV/SLC16A10/ATP1B1/ACTB/ATP2A2/MED13/KRAS/RHEB/NOTCH2/PIK3R1/CTNNB1/NRAS	1.31319330466354
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/837	48/9376	1.63361210673039	ACAA2/IL4I1/ALDH2/BCAT1/HADHB/ALDH3A2/HADHA	1.37782695674475
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/837	76/9376	1.47393573539584	BAX/GADD45B/KRAS/CDKN1A/CAMK1D/CAMK2D/CDK6/PIK3R1/RB1/NRAS	1.29876219537039
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/837	31/9376	1.80675993371103	ALDH2/CNDP2/ALDH3B1/ALDH3A2/HADHA	1.40857629740368
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/837	23/9376	1.94815853721885	CTSA/ANPEP/ATP6AP2/PRCP	1.425326208975
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/837	23/9376	1.94815853721885	ATP1B3/GLS/ATP1B1/GLUD1	1.425326208975
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/837	106/9376	1.37381934582178	HSP90AA1/HSP90AB1/NFKB1/MMP9/NFKBIA/KRAS/CDKN1A/PLAU/PIK3R1/CTNNB1/RB1/NRAS/CREB3	1.21176861252052
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/837	205/9376	1.25679983681557	CTSD/CD36/NFKB1/CYBA/TGFBR1/NCF2/MMP9/ATP2A2/TGFBR2/PPIF/PDK4/NDUFA13/SDHD/RAC1/CAMK2D/SDHB/CYBB/COX8A/PIK3R1/MPC1/NDUFB5/COX6A1/NDUFB2	1.16387995247732
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/837	59/9376	1.51890326630622	GPX1/ANPEP/LAP3/GSTO1/GPX4/MGST2/GSTK1/TXNDC12	1.25175467749242
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/837	69/9376	1.46111890291413	ALOX5AP/FCER1G/ALOX5/LCP2/BTK/KRAS/RAC1/PIK3R1/NRAS	1.20358696242501
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/837	60/9376	1.49358821186778	GNA13/GNAI2/KRAS/ITPR2/GNA12/PPP2CA/NRAS/GNAQ	1.20079957293854
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/837	16/9376	2.10035842293907	HEXB/HEXA/GBGT1	1.37911696077531
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/837	42/9376	1.60027308414405	AOC1/IL4I1/ALDH2/KMO/ALDH3A2/HADHA	1.22063123115692
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/837	170/9376	1.25197835406564	RHOA/RAB13/JUN/RAP1A/ACTR3/ACTB/ARPC4/VASP/PRKAG2/RUNX1/RAC1/MSN/HSPA4/PPP2CA/ARHGEF2/RAB8A/RAPGEF2/HCLS1/WAS	1.03799932382432
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/837	17/9376	1.97680792747206	CYP27A1/HSD3B7/HSD17B4	1.26201283849197
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/837	44/9376	1.52753339850114	HEXB/MGAT1/MGAT4A/HEXA/MAN1A1/RPN1	1.09807952560585
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	22/837	203/9376	1.21400027072997	SPP1/FN1/VEGFA/ITGAV/ZYX/FLNA/RHOA/JUN/RAP1A/VEGFB/ACTB/PARVB/XIAP/VASP/TLN1/HGF/RAC1/RAPGEF1/PIK3R1/CTNNB1/ILK/EMP1	0.96505375610009
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/837	65/9376	1.37869681095488	SPP1/KRAS/ARRB2/ITPR2/PIK3R1/KCNN4/NRAS/GNAQ	0.959168755374589
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	25/837	238/9376	1.17667138540004	C3/STAT1/C1QB/TNFRSF1A/C1QA/NFKB1/C1QC/JUN/C5AR1/HBEGF/C2/C3AR1/NFKBIA/IRAK1/CXCL10/TLR2/CYBB/NRP1/PIK3R1/STAT3/IFIH1/IFNAR1/RPS27L/TRAF3/IL6R	0.864318834217217
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/837	46/9376	1.46111890291413	PSME2/PSMB9/PSMB8/PSMB10/PSMD13/PSMF1	0.981512602491252
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/837	115/9376	1.26630304919225	GNB4/GNAI2/KRAS/GNG5/JAK2/ITPR2/CAMK2D/PIK3R1/PIK3R5/NRAS/GNAQ/CREB3/ADCY7	0.89958245724317
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/837	166/9376	1.21466511206115	ATP1B3/GNA13/RGS2/SLC8A1/RHOA/MEF2A/ATP1B1/ATP2A2/GNAI2/VASP/PPIF/ATP2B1/ITPR2/PIK3R5/GNA12/GNAQ/CREB3/ADCY7	0.87363607058096
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/837	37/9376	1.51377183635248	IL18/ICAM1/APOL1/IL10/GNAQ	0.980315407462954
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/837	76/9376	1.32654216185625	ATP1B3/ATP1B1/ACTB/GNAI2/ITPR2/CAMK2D/SLC4A2/GNAQ/ADCY7	0.894848358837527
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/837	67/9376	1.33754168226966	FBP1/AKR1A1/ALDH2/ADPGK/ALDH3B1/GALM/ALDH3A2/HK1	0.868076815231649
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/837	38/9376	1.47393573539584	ATP1B3/SGK1/ATP1B1/KRAS/PIK3R1	0.91649305909493
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	18/837	170/9376	1.18608475648324	HMOX1/BAX/GSTO1/TGFBR1/ACTB/GADD45B/MGST2/TGFBR2/KRAS/PBRM1/CDKN1A/HGF/CDK6/PIK3R1/CTNNB1/RB1/APC/NRAS	0.766557318464335
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	28/837	275/9376	1.14055827088085	HSPA1A/HSPA1B/C1QB/BAX/C1QA/CYBA/C1QC/NCF2/CYCS/CCL5/PRNP/PPIF/NDUFA13/ITPR2/SDHD/RAC1/SDHB/STIP1/CYBB/COX8A/PIK3R1/HSPA6/NDUFB5/COX6A1/NDUFB2/HSPA8/PSMD13/CREB3	0.740667103572787
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/837	99/9376	1.24465684322315	BAX/JUN/HBEGF/MMP9/KRAS/CDKN1A/NOTCH2/PIK3R1/RB1/NRAS/ADCY7	0.766153953921098
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/837	99/9376	1.24465684322315	HIF1A/JUN/KRAS/GPCPD1/RHEB/RALGDS/RAC1/EIF4EBP1/PIK3R1/NRAS/WAS	0.766153953921098
NA	NA	hsa04517	IgSF CAM signaling	30/837	299/9376	1.12393761762626	CD84/NRP2/ITGB2/RHOA/RAP1A/ACTR3/ACTB/ICAM1/ARPC4/PPFIA1/LCP2/EPB41L3/NCK1/PTPN6/ITGAX/RAC1/SLAMF7/ITGAM/MSN/NRP1/PIK3R1/ARF6/PMP22/CTNNB1/DOK1/CSK/CADM1/RAPGEF2/EPB41L2/CD80	0.681887031048436
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/837	142/9376	1.18330051996567	UBE2L6/UBE2D3/UBE2E2/STUB1/HERC1/XIAP/UBE2G2/UBE2A/UBE3A/RNF7/UBE2I/SMURF2/UBE2Z/PIAS1/SOCS1	0.689061197284427
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/837	184/9376	1.15671913147369	CXCR4/RHOA/PLXNC1/GNAI2/SEMA3C/KRAS/NCK1/SSH1/RRAS/LIMK1/DPYSL2/RAC1/CAMK2D/NRP1/PIK3R1/ILK/SEMA4A/NRAS/CFL1	0.672157084211155
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/837	50/9376	1.344229390681	AOC1/LAP3/ALDH2/CNDP2/SAT1/ALDH3A2	0.764064646369731
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/837	60/9376	1.30688968538431	VEGFA/HSPB1/KRAS/SPHK1/RAC1/PIK3R1/NRAS	0.746600089483973
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/837	21/9376	1.60027308414405	DSE/CHST11/B3GAT3	0.862147319306557
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/837	21/9376	1.60027308414405	ALDH2/BCAT1/ALDH3A2	0.862147319306557
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	24/837	238/9376	1.12960452998404	VEGFA/REL/NFKB1/RHOA/RAP1A/GNB4/RAB5C/RALA/MRAS/VEGFB/RASGRP3/ABL2/KRAS/STK4/GNG5/RRAS/RALGDS/CSF1R/HGF/RAC1/PIK3R1/ARF6/NRAS/RASSF5	0.634056477292155
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/837	31/9376	1.44540794696882	AKR1A1/ALDH2/ALDH3A2/HSD17B14	0.777667619027105
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/837	71/9376	1.26218722129672	HIF1A/GLS/KRAS/SLC7A5/PIK3R1/SLC16A3/NRAS/HK1	0.694268349391145
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/837	154/9376	1.16383497028658	RGS2/RHOA/JUN/ACTB/GNAI2/KRAS/CDKN1A/CAMK1D/PRKAG2/CD38/ITPR2/CAMK2D/PIK3R5/NRAS/GNAQ/ADCY7	0.6417993436337
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/837	51/9376	1.31787195164804	PLD3/PLA2G7/LPCAT2/AGPS/PAFAH1B2/TMEM86A	0.712619556548456
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/837	72/9376	1.24465684322315	NFKB1/NFKBIA/CXCL10/ZNFX1/CYLD/TRADD/IFIH1/TRAF3	0.652429553866431
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/837	32/9376	1.40023894862605	GAA/GLB1/GALM/HK1	0.710023599271704
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/837	23/9376	1.46111890291413	GLUL/GLS/GLUD1	0.693180340605437
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/837	138/9376	1.13642581337766	FBP1/RHOQ/KRAS/PTPN1/RHEB/PRKAG2/RAPGEF1/EIF4EBP1/PIK3R1/NRAS/PRKAR1A/SOCS1/PRKAR2A/HK1	0.505466032791942
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/837	54/9376	1.24465684322315	SDS/SDSL/IL4I1/BCAT1/APIP/MAT2A	0.564474800583949
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/837	75/9376	1.19487056949423	GPX1/ATP1B3/ATP1B1/ITPR2/CANX/GNAQ/CREB3/ADCY7	0.530465231801419
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/837	98/9376	1.14305220296004	ATP1B3/NR4A2/ATP1B1/CAMK1D/ATP2B1/ITPR2/CAMK2D/GNAQ/CREB3/ADCY7	0.445682174471347
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	19/837	195/9376	1.09146830867261	FCGR3A/FPR3/C3/FCGR1A/ITGB2/NFKB1/CYBA/C5AR1/NCF2/ACTB/PPIF/TLR2/RAC1/ITGAM/ATG7/CYBB/PIK3R1/SIGLEC9/HDAC5	0.404099042210727
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/837	35/9376	1.28021846731524	FBP1/HSD17B14/HK1/PFKFB3	0.519970793093438
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/837	67/9376	1.17034897198595	RAP1A/KRAS/RPS6KA1/ITPR2/CAMK2D/NRAS/GNAQ	0.438096984304926
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/837	46/9376	1.21759908576178	FTL/FTH1/HMOX1/ALAS1/BLVRB	0.463169572134263
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/837	47/9376	1.19169272223493	ME2/AKR1A1/ALDH2/GRHPR/ALDH3A2	0.412460028746045
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/837	155/9376	1.08405596022662	NCEH1/RAP1A/GNAI2/CDKN1A/ITPR2/CAMK2D/CDK6/USP8/CTNNB1/RB1/APC/AHR/GNAQ/CREB3/ADCY7	0.33036209553527
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/837	37/9376	1.21101746908199	GLUL/IL4I1/GLS/GLUD1	0.402637243904871
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/837	233/9376	1.0576912229965	FN1/VIM/FMNL2/ATP1B3/ITGAV/ZYX/PDLIM7/ATP1B1/LMNA/ACTB/FHL3/FMNL1/SDC2/PLEC/TLN1/CAPZB/FMNL3/FBN1/CAPZA2/AMPD3/SDC3/CAPZA1	0.279182509511247
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/837	16/9376	1.40023894862605	IL4I1/ALDH3B1	0.501633205059424
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/837	93/9376	1.08405596022662	MAP3K2/JUN/HBEGF/KRAS/ITPR2/CAMK2D/NRAS/GNAQ/ADCY7	0.255041393846937
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/837	93/9376	1.08405596022662	ATP1B3/ATP1B1/CD38/ATP2B1/ITPR2/SLC4A2/KCNN4/GNAQ/ADCY7	0.255041393846937
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/837	17/9376	1.31787195164804	GLUL/GLUD1	0.410683075652865
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/837	63/9376	1.0668487227627	LTA4H/GPX4/ALOX5/LTC4S/PTGS1/TBXAS1	0.16667230730188
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/837	41/9376	1.09286942331789	SDS/SDSL/ALAS1/GRHPR	0.186574538649613
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/837	30/9376	1.12019115890084	ACO2/SDHD/SDHB	0.206426344608513
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/837	154/9376	1.01835559900076	ATP1B3/SLC8A1/ATP1B1/ATP2A2/GNAI2/CREM/ATP2B1/CAMK2D/PIK3R5/PPP2R3C/PPP2CA/GNAQ/CREB3/ADCY7	0.0719053531128579
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/837	31/9376	1.08405596022662	GLUL/ACO2/GRHPR	0.146758940650525
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/837	31/9376	1.08405596022662	TMEM208/SRPRB/SEC61A1	0.146758940650525
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/837	43/9376	1.04203828734962	CD36/ABCA1/AGPAT2/SLC27A1	0.0864994746372515
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/837	157/9376	0.998896574816032	ID2/YWHAH/ITGB2/SERPINE1/TGFBR1/SMAD7/ACTB/TGFBR2/MOB1A/AREG/YWHAG/CTNNB1/PPP2CA/APC	-0.00436511481086802
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/837	20/9376	1.12019115890084	LIPA/SOAT1	0.168456306539203
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/837	89/9376	1.00691340125918	GLUL/GABARAP/GABARAPL1/GLS/GNB4/GNAI2/GNG5/ADCY7	0.0205160573953454
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/837	101/9376	0.998190141594805	MITF/GNAI2/KRAS/CAMK2D/CTNNB1/NRAS/GNAQ/CREB3/ADCY7	-0.005725233281308
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/837	148/9376	0.983951693629113	BAX/JUN/GADD45B/KRAS/CDKN1A/NOTCH2/CDK6/NFKB2/PIK3R1/CTNNB1/RB1/APC/NRAS	-0.0616099890866561
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/837	45/9376	0.995725474578521	ABCA1/ABCC3/TAP1/ABCG1	-0.00899859957710675
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/837	115/9376	0.974079268609423	DUSP1/GNB4/ALOX5/GNAI2/KRAS/GNG5/ITPR2/PTGS1/NRAS/GNAQ	-0.0875612776819613
NA	NA	hsa04081	Hormone signaling	19/837	219/9376	0.971855343338625	CSH1/CSH2/HAMP/GNA13/ITGAV/RHOA/SLC16A10/GNB4/GNAI2/STAT5A/GNG5/JAK2/PIK3R1/GNA12/GNA15/STAT3/ADIPOR2/GNAQ/ADCY7	-0.131942973062679
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/837	104/9376	0.969396195202647	PLD3/PLA2G15/GPCPD1/AGPAT2/LPCAT2/LPIN2/PNPLA6/SGMS1/AGPAT3	-0.0982540004317148
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	22/837	254/9376	0.970244310858992	CXCR4/VEGFA/SLC8A1/ORAI2/VEGFB/PTAFR/ATP2A2/PPIF/CAMK1D/SPHK1/CD38/P2RX4/ATP2B1/MCOLN1/ITPR2/HGF/P2RX7/CAMK2D/GNA15/GNAQ/TPCN1/ADCY7	-0.150517396507904
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/837	116/9376	0.965682033535204	FBP1/ME2/SDS/SDSL/ACO2/ADPGK/GLUD1/SDHD/SDHB/HK1	-0.11643670505532
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/837	116/9376	0.965682033535204	GLUL/GLS/GNB4/HOMER3/SLC1A3/GNAI2/GNG5/ITPR2/GNAQ/ADCY7	-0.11643670505532
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/837	34/9376	0.988403963736032	POLR2B/POLR3GL/CRCP	-0.0212067419753092
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/837	34/9376	0.988403963736032	BHLHE40/PRKAG2/BHLHE41	-0.0212067419753092
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/837	10/9376	1.12019115890084	PAPSS1	0.119052989806973
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/837	59/9376	0.949314541441387	GNAI2/PTGS1/PIK3R1/ADCY7/MGLL	-0.122268954449308
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	20/837	235/9376	0.953354177787946	ACSL3/ACTB/KRAS/RHEB/PRKAG2/NDUFA13/COX14/RPS6KA1/SDHD/SDHB/COX8A/NDUFAF3/CPT1A/NDUFB5/COX6A1/NDUFB2/NRAS/CREB3/ADCY7/MGLL	-0.226722535488397
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/837	48/9376	0.933492632417363	ATP1B3/ATP1B1/PIK3R1/HK1	-0.144624199733735
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/837	36/9376	0.933492632417363	GALNT7/B4GALT5/ST6GALNAC4	-0.125167745862334
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	33/837	388/9376	0.952739903188856	APOE/TNFRSF1A/NFKB1/LPL/ATP2A2/CYCS/KRAS/PPIF/RTN4/APH1A/NDUFA13/ITPR2/SDHD/ADAM10/BID/LRP1/SLC39A11/SDHB/CYBB/COX8A/PIK3R1/CTNNB1/NDUFB5/COX6A1/APC/BECN1/SLC11A2/NDUFB2/NRAS/APH1B/PSEN1/PSMD13/GNAQ	-0.297662276085087
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/837	24/9376	0.933492632417363	HS3ST1/B3GAT3	-0.102133447247937
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/837	49/9376	0.91444176236803	NFKB1/JUN/GNAI2/CREB3	-0.187989564698662
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/837	37/9376	0.908263101811489	IL4I1/FAH/ALDH3B1	-0.175040919653212
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/837	37/9376	0.908263101811489	NANS/UAP1/HK1	-0.175040919653212
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/837	86/9376	0.911783501430913	ATP1B3/ATP1B1/CAMK2D/KCNN4/GNAQ/CREB3/ADCY7	-0.257297783568488
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/837	110/9376	0.916520039100684	HSP90AA1/HSP90AB1/GNAI2/KRAS/RPS6KA1/CPEB4/PIK3R1/MAD1L1/ADCY7	-0.275725727984161
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/837	75/9376	0.896152927120669	GLUL/SDS/SDSL/BCAT1/ACO2/MAT2A	-0.282686409393726
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	27/837	323/9376	0.936382702486767	VEGFA/VIM/ST14/HMOX1/TIMP3/NFKB1/RHOA/MARCKS/GLS/CD44/MMP9/KRAS/MCL1/CDKN1A/NOTCH2/PLAU/UBE2I/CDK6/PIK3R1/ZEB2/DDIT4/STAT3/DICER1/APC/NRAS/SOCS1/HDAC5	-0.364271402266813
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/837	63/9376	0.889040602302251	ALDH2/COLGALT1/ALDH3A2/HADHA/KMT2E	-0.276652388659093
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/837	63/9376	0.889040602302251	BAX/GADD45B/CDKN1A/CTNNB1/APC	-0.276652388659093
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/837	12/9376	0.933492632417363	COQ2	-0.0721729636826375
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/837	12/9376	0.933492632417363	CD46	-0.0721729636826375
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/837	89/9376	0.881049226101781	MAP3K2/GNAI2/KRAS/ITPR2/NRAS/GNAQ/ADCY7	-0.352995698213892
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/837	150/9376	0.896152927120669	BAX/TGFBR1/GADD45B/TGFBR2/KRAS/CDKN1A/HGF/PIK3R1/CTNNB1/RB1/APC/NRAS	-0.401400606603419
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/837	65/9376	0.861685506846797	NCEH1/ITPR2/GNAQ/CREB3/ADCY7	-0.350324947055952
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/837	27/9376	0.829771228815434	HSD17B4/ELOVL1	-0.277317404444782
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/837	103/9376	0.870051385554047	ATP1B3/SLC8A1/SLC16A10/SLC7A7/SLC3A2/ATP1B1/KCNN4/PRCP	-0.415169074728569
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/837	29/9376	0.772545626828163	MOB1A/RASSF4	-0.384062610280515
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/837	56/9376	0.800136542072026	MGAT1/MGAT4A/MAN1A1/RPN1	-0.469639173204698
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	11/837	144/9376	0.855701579715917	ID2/SKIL/KLF4/KRAS/JAK2/PIK3R1/CTNNB1/STAT3/APC/NRAS/ZFHX3	-0.546310798818983
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/837	69/9376	0.811732723841186	CTSB/PTGER4/GNAI2/ITPR2/GNAQ	-0.491404793002409
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/837	107/9376	0.837526100112775	FBP1/SIK1/PRKAG2/ITPR2/CAMK2D/CPT1A/GNAQ/CREB3	-0.529180598588972
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/837	82/9376	0.819652067488417	TYMP/GSTO1/UPP1/MGST2/ITPA/TK2	-0.513525034597405
Cellular Processes	Cell motility	hsa04814	Motor proteins	15/837	194/9376	0.866127184717141	MYO9B/ACTB/MYO5A/DYNC1I2/CAPZB/DYNC1LI1/CAPZA2/ACTR10/MYO1F/KIF1B/MYO1E/KIFC3/ACTR1A/CAPZA1/DYNC1H1	-0.589887886162592
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/837	133/9376	0.842248991654764	GNB4/GNAI2/ARRB2/GNG5/ITPR2/CAMK2D/PPP2R3C/PPP2CA/GNAQ/CREB3	-0.573635933351087
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/837	30/9376	0.746794105933891	PIGT/B3GALT4	-0.434876971179897
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/837	30/9376	0.746794105933891	NFKB1/ABCC3	-0.434876971179897
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/837	83/9376	0.809776741374099	UBE2D3/MAX/PHC2/ASXL2/KDM2B/USP7	-0.544966184835182
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/837	44/9376	0.76376669925057	POLD4/PARP4/MBD4	-0.491728014863644
NA	NA	hsa04981	Folate transport and metabolism	2/837	31/9376	0.722703973484411	SLCO2B1/ABCC3	-0.484149737726055
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/837	85/9376	0.790723170988826	TYMP/UPP1/ITPA/AMPD3/DCTD/TK2	-0.606798137987458
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/837	59/9376	0.759451633153109	TYMP/UPP1/DCTD/TK2	-0.580276831763217
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/837	86/9376	0.781528715512211	SLC8A1/ITGAV/LMNA/ACTB/ATP2A2/CTNNB1	-0.637207077857959
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/837	17/9376	0.658935975824021	PAPSS1	-0.440646687186238
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/837	138/9376	0.811732723841186	YWHAH/RPS6KA1/ITPR2/CAMK2D/CPEB4/YWHAG/MAD1L1/PPP2CA/SMC1A/ADCY7	-0.697541842181342
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/837	87/9376	0.772545626828163	ATP1B3/SLC8A1/ATP1B1/ATP2A2/COX8A/COX6A1	-0.667289508274351
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/837	47/9376	0.715015633340959	PIK3R1/SOCS1/HK1	-0.613193128533605
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/837	226/9376	0.842621668199744	ATP1B3/NFKB1/RHOA/JUN/RAP1A/ATP1B1/ATP2A2/NFKBIA/GNAI2/RRAS/ATP2B1/RAC1/CAMK2D/PIK3R1/SUCNR1/CREB3/ADCY7	-0.749779341899947
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/837	33/9376	0.678903732667174	BCAT1/ACO2	-0.578487411870462
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/837	18/9376	0.622328421611576	ACSL3	-0.502115809681528
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/837	18/9376	0.622328421611576	TCN2	-0.502115809681528
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/837	89/9376	0.755185050944384	SPP1/FN1/CD36/ITGAV/CD47/CD44	-0.726507453823129
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/837	154/9376	0.800136542072026	PDXK/AKR1A1/ALDH2/BCAT1/RDH11/KMO/ALAS1/MAT2A/ALDH3A2/MTHFD2/COQ2	-0.782935632668405
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/837	49/9376	0.685831321776022	COLGALT1/MFNG/GALNT7	-0.690295110043391
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/837	63/9376	0.711232481841801	POLD4/ERCC1/CCNH/POLR2B	-0.719977084620066
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/837	90/9376	0.746794105933891	ATP1B3/NCEH1/ABCC3/ATP1B1/SLC4A2/ADCY7	-0.755658525193582
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/837	117/9376	0.765942672752709	ACTB/PBRM1/EP400/CHD4/BAZ2B/EPC1/BPTF/BCL7C	-0.79758686030764
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/837	144/9376	0.77791052701447	ATXN1/ATP2A2/CYCS/PPIF/ITPR2/PIK3R1/BECN1/PUM2/PSMD13/GNAQ	-0.840826096066383
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/837	36/9376	0.622328421611576	GAA/HK1	-0.710782908140401
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/837	36/9376	0.622328421611576	POLD4/RNASEH2B	-0.710782908140401
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/837	158/9376	0.779879920753747	YWHAH/GADD45B/NIPBL/CCNH/CDKN1A/CDK6/YWHAG/MAD1L1/RB1/PPP2CA/SMC1A	-0.873604198355413
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/837	149/9376	0.751806146913313	GNB4/GNAI2/GNG5/NDUFA13/ITPR2/NDUFB5/NDUFB2/GNAQ/ADCY7/MGLL	-0.956089955550978
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/837	83/9376	0.674813951145082	ACSL3/HSD17B4/GSTK1/AGPS/FAR1	-0.9316179403414
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/837	39/9376	0.574457004564531	MAT2A/MTHFD2	-0.833713686028936
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/837	97/9376	0.692901747773713	GNB4/GNAI2/GNG5/CAMK2D/GNAQ/ADCY7	-0.951825827261373
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/837	268/9376	0.794165373847608	DUSP1/BAX/UBE2L6/CYCS/GNAI2/UBE2G2/PPIF/NDUFA13/ITPR2/SDHD/CAMK2D/SLC39A11/SDHB/COX8A/NDUFB5/COX6A1/SLC11A2/NDUFB2/PSMD13	-1.0703336551495
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/837	23/9376	0.487039634304711	FNTA	-0.771111396133682
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/837	23/9376	0.487039634304711	POLD4	-0.771111396133682
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	27/837	368/9376	0.821879382889201	GPX1/RANBP2/TNFRSF1A/BAX/CHCHD10/SQSTM1/PFN1/ACTB/CYCS/ANXA7/DERL1/ACTR10/NDUFA13/SDHD/RAC1/BID/NUP62/SDHB/COX8A/SETX/ACTR1A/NDUFB5/COX6A1/BECN1/NDUFB2/RAB8A/PSMD13	-1.09136185937889
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/837	99/9376	0.678903732667174	PTGER4/ITPR2/CAMK2D/PIK3R1/GNAQ/ADCY7	-1.00552746273263
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/837	99/9376	0.678903732667174	SLC8A1/ITGAV/LMNA/ACTB/ATP2A2/PRKAG2	-1.00552746273263
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/837	56/9376	0.600102406554019	ARRB2/SPOP/SMURF2	-0.939679404627333
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	36/837	480/9376	0.840143369175627	GPX1/TNFRSF1A/BAX/UBE2L6/NFKB1/SQSTM1/ATXN1/ATP2A2/CYCS/KRAS/UBE2G2/PRNP/PPIF/DERL1/ACTR10/NDUFA13/ITPR2/SDHD/RAC1/CAMK2D/BID/SDHB/CYBB/COX8A/CTNNB1/ACTR1A/NDUFB5/COX6A1/APC/BECN1/NDUFB2/NRAS/RAB8A/PSEN1/PSMD13/GNAQ	-1.12563800405221
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	22/837	308/9376	0.800136542072026	GPX1/BAX/AP2S1/SLC1A3/CYCS/PPIF/AP2M1/ACTR10/NDUFA13/SDHD/POLR2B/SDHB/COX8A/ACTR1A/NDUFB5/COX6A1/BECN1/NDUFB2/CLTC/PSMD13/GNAQ/CREB3	-1.1166006080359
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/837	41/9376	0.546434711658945	POLD4/NBN	-0.911212015714221
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/837	73/9376	0.613803374740184	GSTO1/MGST2/ALDH3B1/GSTK1	-1.03705849757991
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/837	26/9376	0.430842753423399	TCN2	-0.909825277700203
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/837	44/9376	0.50917779950038	CCNH/TAF7	-1.02166386168681
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/837	105/9376	0.640109233657621	SLC8A1/ITGAV/LMNA/ACTB/ATP2A2/ADCY7	-1.16103930848896
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/837	91/9376	0.615489647747712	GNB4/GNAI2/ARRB2/GNG5/ADCY7	-1.15393843634644
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/837	27/9376	0.414885614407717	HADHA	-0.953201985696217
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/837	78/9376	0.574457004564531	BTG1/BTG2/C1D/HSPA9	-1.18151934611407
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/837	28/9376	0.400068271036013	PCBD1	-0.995328307131222
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/837	108/9376	0.622328421611576	RANBP2/KPNA4/SUMO3/UBE2I/NUP62/SUMO1	-1.23588490804439
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/837	79/9376	0.567185396911816	GSTO1/MGST2/ALDH3B1/GSTK1	-1.20945272107368
NA	NA	hsa04519	Cadherin signaling	28/837	404/9376	0.776370110129293	LHFPL2/VIM/YWHAH/NFKB1/RHOA/MRAS/NCKAP1L/ACTR3/CYFIP1/ACTB/ARPC4/NFKBIA/KRAS/VASP/MOB1A/RRAS/APH1A/MYO1F/ADAM10/RAC1/YWHAG/MYO1E/CTNNB1/APC/NRAS/TAOK3/APH1B/PSEN1	-1.43853608501737
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/837	31/9376	0.361351986742205	FBP1	-1.11505841610263
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/837	68/9376	0.494201981868016	ALDH1A1/RDH11/DHRS4L2	-1.31053387983514
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/837	32/9376	0.350059737156511	HADHA	-1.15299354628002
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/837	69/9376	0.487039634304711	JUN/CAMK2D/CREB3	-1.33890067071612
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/837	52/9376	0.430842753423399	ALOX5/ADCY7	-1.28847996372295
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/837	70/9376	0.480081925243216	GSTO1/MGST2/GSTK1	-1.3669331381485
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/837	36/9376	0.311164210805788	AKR1A1	-1.29639807041847
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/837	38/9376	0.294787147079167	CD38	-1.36373486237888
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/837	98/9376	0.457220881184015	ITPR2/PI4K2A/PIK3R1/PIP4K2A	-1.69103986465087
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/837	134/9376	0.501578130851121	GNA13/RHOA/ITPR2/GNA12/GNAQ/ADCY7	-1.81932952290857
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/837	103/9376	0.435025692777024	GSPT1/ETF1/PPP2R3C/PPP2CA	-1.80502009486784
NA	NA	hsa04382	Cornified envelope formation	11/837	217/9376	0.56783883630918	ST14/S100A10/DST/S100A11/PLEC/UGCG/S100A6/SLC27A1/ELOVL1/PPP2R3C/PPP2CA	-2.01649167840094
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/837	128/9376	0.437574671445639	ITPA/AMPD3/PAPSS1/NUDT9/ADCY7	-2.00581467968111
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/837	54/9376	0.207442807203859	ERCC1	-1.82859615721814
NA	NA	hsa04082	Neuroactive ligand signaling	9/837	199/9376	0.506619117090831	GNB4/SLC1A3/GNAI2/P2RY11/GNG5/P2RX4/OGFR/GNAQ/ADCY7	-2.20243627064488
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/837	78/9376	0.287228502282266	PI4K2A/PIP4K2A	-1.97900875574373
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/837	191/9376	0.469190014199303	GNB4/GNAI2/KRAS/GNG5/NRAS/SLC29A3/HDAC5/CREB3	-2.3203903363313
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/837	178/9376	0.440524613050891	RHOA/JUN/RAC1/CAMK2D/CTNNB1/APC/PSEN1	-2.35933246792763
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/837	243/9376	0.414885614407717	HSPA1A/HSPA1B/PRPF40A/RBM25/HSPA6/DDX5/BCAS2/HSPA8/PCBP1	-2.89322390112686
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	16/837	370/9376	0.484406987632794	CSH1/FPR3/C3/CSH2/C5AR1/C3AR1/PTGER4/PTAFR/P2RY11/TSPO/P2RX4/NR3C1/P2RX7/LPAR6/OGFR/GPR35	-3.16801167951158
Genetic Information Processing	Translation	hsa03010	Ribosome	6/837	222/9376	0.302754367270496	MRPL34/MRPS18B/MRPS28/MRPL41/MRPL12/RPS27L	-3.29155939583418
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/837	183/9376	0.0612126316339255	UTP18	-4.01521691872152
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/837	449/9376	0.0997943125969565	RGS2/SLC8A1/ARRB2/CAMK2D	-6.12007882768