category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	28/566	95/9376	4.88242514413242	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ATP6V0E1/CCL3/CXCL2/HLA-DQB1/ITGB2/CXCL3/ATP6V1E1/HLA-DMA/ACP5/ATP6V0D1/HLA-DQA1/IL1B/CTSL/CCL20/HLA-DQA2/HLA-DMB/ATP6V1B1/ATP6V1D/IL18/ATP6V1H/TNFSF13B/ATP6V1G1/IL1A/ATP6V1C1	9.63991949153161
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	34/566	155/9376	3.63369428929671	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DPB1/OLR1/CTSS/ATP6V0E1/HLA-DQB1/ITGB2/HLA-A/ATP6V1E1/HLA-DMA/MSR1/ATP6V0D1/HLA-DQA1/FCGR3A/CTSL/STX7/HLA-DQA2/HLA-DMB/NCF2/ATP6V1B1/ATP6V1D/ATP6V1H/ATP6V1G1/CD36/HLA-F/ATP6V1C1/RILP/CD14/COLEC12/FCGR1A/RAB5A	8.38007874763261
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	29/566	138/9376	3.48112869360373	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/ATP6V0E1/ATP6V1E1/MT-ATP8/ATP6V0D1/COX7C/UQCRQ/NDUFAB1/UQCRC2/ATP6V1B1/ATP6V1D/ATP6V1H/ATP6V1G1/MT-ND6/ATP6V1C1/NDUFA13/LHPP	7.44227571070599
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	39/566	238/9376	2.7144935712801	RPS29/RPS15A/RPL34/RPS14/RPL23/RPS25/RPS28/RPL37/FAU/RPS20/RPS27/RPL31/RPL36A/RPS12/RPL10A/RPLP2/RPL30/RPS8/RPL38/RPS24/RPS4Y1/RPS21/C1QA/C1QB/NFKBIA/RPL7/RPL23A/RPL21/UBA52/RPL27/PLCG2/IL1B/RPS10/CXCL10/C1QC/C5AR1/RPL17/RPL36AL/EGFR	6.7905454799595
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/566	44/9376	5.27079987150658	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DPB1/HLA-DQB1/HLA-A/HLA-DMA/HLA-DQA1/IL1B/HLA-DQA2/HLA-DMB/IL1A/HLA-F	7.19704293853914
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/566	45/9376	5.15367098547311	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DPB1/HLA-DQB1/HLA-A/HLA-DMA/HLA-DQA1/IL1B/HLA-DQA2/HLA-DMB/IL1A/HLA-F	7.07913435065369
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	37/566	250/9376	2.45167491166078	VAMP8/CTSD/CTSB/HEXB/LAPTM5/LGMN/CTSS/ATP6V0E1/CD68/ASAH1/CLTA/ATP6V1E1/ACP5/ATP6V0D1/CTSL/LIPA/CTSZ/ARL8A/GNPTG/PSAP/ATP6V1B1/ROGDI/ATP6V1D/ATP6V1H/ATP6V1G1/CLTB/BLOC1S2/VAMP7/LAMTOR5/ATP6V1C1/SLC11A1/CTBS/DTNBP1/RRAGB/SLC29A3/LAMTOR3/SLC17A5	5.8966458221894
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	32/566	205/9376	2.58581401361717	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/CTSD/MT-CO2/MT-CO1/MT-CO3/UQCRB/MMP9/MT-ATP8/COX7C/CPT2/UQCRQ/NDUFAB1/UQCRC2/NCF2/MPC2/PARP1/SLC25A5/TGFBR1/PDK4/CD36/CAMK2G/MT-ND6/GSR/NDUFA13	5.81871029332269
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/566	78/9376	3.822777928785	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/EEF1A1/NFKBIA/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/IL1B/FCGR3A/HLA-DQA2/HLA-DMB/NCF2/IL1A/PTPN6/FCGR1A	6.3450513776679
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	34/566	227/9376	2.48115689357264	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/GSTA3/GSTT1/MT-CO3/UQCRB/NFKBIA/NFE2L2/MT-ATP8/SOD1/HMOX1/COX7C/UQCRQ/KRAS/EPHX2/NDUFAB1/CAT/PTPN1/UQCRC2/NCF2/SLC25A5/EGFR/MT-ND6/GSTM3/NDUFA13	5.72575918694946
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	18/566	82/9376	3.63630095664914	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/CTSB/HLA-B/HLA-DPB1/LGMN/CTSS/HLA-DQB1/HLA-A/HLA-DMA/HLA-DQA1/CTSL/HLA-DQA2/HLA-DMB/HLA-F/HSPA1A	6.07724127720777
Human Diseases	Immune disease	hsa05310	Asthma	11/566	32/9376	5.69434628975265	HLA-DRA/PRG2/HLA-DRB1/HLA-DPA1/HLA-DPB1/FCER1G/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB	6.74201317837378
Human Diseases	Immune disease	hsa05330	Allograft rejection	12/566	39/9376	5.09703723838	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DPB1/HLA-DQB1/HLA-A/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-F	6.49836999585039
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	28/566	181/9376	2.56259883255569	HLA-DRA/CD74/CTSD/HLA-DRB1/HLA-DPA1/HLA-DPB1/CTSS/FCER1G/HLA-DQB1/ITGB2/HLA-DMA/ATP6V0D1/HLA-DQA1/IL1B/FCGR3A/HLA-DQA2/HLA-DMB/LSP1/FADD/TRADD/IL18/ATP6V1H/IL1A/CALM2/CAMK2G/CD14/FCGR1A/RAB5A	5.38042789626737
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	20/566	105/9376	3.15530876661619	GABARAPL1/GABARAPL2/SQSTM1/OPTN/UBA52/MAP1LC3B/GABARAP/KRAS/UBB/MRAS/AMFR/CALCOCO2/PINK1/SIAH1/TBC1D17/FIS1/CCZ1B/BCL2L1/RAB5A/CITED2	5.62920097191104
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	19/566	100/9376	3.14742049469965	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/CD59/HLA-DQB1/HLA-DMA/HLA-DQA1/IL1B/CD44/HLA-DQA2/HLA-DMB/CD37/IL1A/CD36/CD14/FCGR1A/CSF3R/CSF2RA	5.47195633620902
Genetic Information Processing	Translation	hsa03010	Ribosome	31/566	222/9376	2.31318244039092	RPS29/RPS15A/RPL34/RPS14/RPL23/RPS25/RPS28/RPL37/FAU/RPS20/RPS27/RPL31/RPL36A/RPS12/RPL10A/RPLP2/RPL30/RPS8/RPL38/RPS24/RPS4Y1/RPS21/RPL7/MRPL46/RPL23A/RPL21/UBA52/RPL27/RPS10/RPL17/RPL36AL	5.0188243865057
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	18/566	99/9376	3.01188564086091	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/C1QA/C1QB/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/FCGR3A/HLA-DQA2/HLA-DMB/KRT23/C1QC/C5AR1/KRT18/FCGR1A	5.10062047135538
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	34/566	268/9376	2.10157692104847	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/NFE2L2/DUSP1/MT-ATP8/UBA52/SOD1/COX7C/PSMD7/PSMB2/UQCRQ/UBB/NDUFAB1/UQCRC2/SLC25A5/TXN/CALM2/CAMK2G/MT-ND6/PINK1/NDUFA13/PSMA3/BCL2L1	4.63742195898392
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	12/566	54/9376	3.68119356105222	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DPB1/HLA-DQB1/HLA-A/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-F	5.00813927469412
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/566	83/9376	2.99374175145813	ECH1/PRDX5/CROT/SOD1/PRDX1/DECR2/SCP2/ECI2/EPHX2/CAT/GSTK1/PEX6/PEX2/PEX3/IDH2	4.62419224285701
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/566	50/9376	3.6443816254417	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB/CXCR4/TNFSF13B	4.75190037536128
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	17/566	105/9376	2.68201245162376	NFKBIA/UBE2I/CXCL2/CXCL3/GADD45B/PLCG2/IL1B/BCL2A1/LY96/PARP1/TRADD/TNFSF13B/GADD45G/CCL4/BIRC3/CD14/BCL2L1	4.39305322471834
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	30/566	248/9376	2.00387552718568	S100A10/DYNLRB1/NFKBIA/ANXA2/MYL12A/CASP4/ARPC2/DYNLT1/IL1B/RAB9A/LY96/TNFSF10/FADD/ARL8A/TRADD/IL18/CTNNB1/DYNLRB2/DYNLL2/TXN/EXOC2/RILP/BIRC3/CD14/MYL12B/PTPRC/SKP1/RAB5A/CYTH3/TCF7L1	4.06091399031252
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/566	70/9376	3.07642604745078	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DPB1/HLA-DQB1/ITGB2/HLA-A/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-F	4.41967020607197
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	26/566	205/9376	2.10097388606395	HLA-DRA/HLA-DRB1/HLA-DPA1/VIM/HLA-B/HLA-DPB1/NFKBIA/HLA-DQB1/HLA-A/CDKN1A/HLA-DMA/GADD45B/PLCG2/PSMD7/HLA-DQA1/CD44/HLA-DQA2/HLA-DMB/CXCL10/FADD/TRADD/CDK6/GADD45G/HLA-F/CIR1/NEDD4	4.03972220481734
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	32/566	275/9376	1.92760681015098	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/C1QA/C1QB/MT-ATP8/SOD1/COX7C/PSMD7/IL1B/PSMB2/UQCRQ/NDUFAB1/UQCRC2/NCF2/C1QC/SLC25A5/IL1A/MT-ND6/HSPA1A/NDUFA13/PSMA3	3.95723296042786
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/566	71/9376	3.03309610312049	ATP6V0E1/NFKBIA/CXCL2/CXCL3/ATP6V1E1/ATP6V0D1/PLCG2/ATP6V1B1/ATP6V1D/ATP6V1H/ATP6V1G1/EGFR/ATP6V1C1	4.35847734752616
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/566	66/9376	3.01188564086091	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/IL1B/HLA-DQA2/HLA-DMB/IL18/IL1A	4.15725168381696
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	29/566	250/9376	1.92158303886926	HLA-B/SH3GLB2/DAB2/FOLR1/HLA-A/CLTA/TSG101/ARPC2/SH3KBP1/PIP5K1B/CHMP5/RAB31/NEDD4L/TGFBR1/RAB11B/CXCR4/CLTB/CHMP1B/EGFR/CHMP1A/HLA-F/STAMBP/EPN3/NEDD4/HSPA1A/CHMP4B/IST1/RAB5A/CYTH3	3.74343369324473
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/566	137/9376	2.2973872224085	CTSD/CTSB/CTSS/NFKBIA/PMAIP1/GADD45B/CTSL/BCL2A1/KRAS/TNFSF10/CTSZ/FADD/PARP1/TRADD/BBC3/GADD45G/NOL3/BIRC3/BCL2L1	3.87724563736575
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	29/566	253/9376	1.8987974692384	SQSTM1/NFKBIA/MYL12A/FOXO4/CASP4/UBA52/HCLS1/CAST/ARPC2/PLCG2/IL1B/MAP1LC3B/CD44/UBB/CAPNS1/TRADD/IL18/WIPI1/CALCOCO2/EGFR/RPS6KA5/WASF2/CD14/MYL12B/BCAR1/RRAGB/BCL2L1/SKP1/CYTH3	3.67332338523871
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/566	235/9376	1.90325539433125	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/MGLL/MT-ATP8/COX7C/PRKAB2/CPT2/UQCRQ/KRAS/NDUFAB1/UQCRC2/COX14/PNPLA2/MT-ND6/NDUFA13/COX20	3.55429556908404
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/566	28/9376	4.14134275618375	ATP6V0E1/ATP6V1E1/ATP6V0D1/ATP6V1B1/ATP6V1D/ATP6V1G1/ATP6V1C1	4.21930469470416
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/566	169/9376	2.05841888473038	GABARAPL1/VAMP8/CTSD/GABARAPL2/CTSB/SQSTM1/OPTN/UBA52/CTSL/MAP1LC3B/STX7/GABARAP/KRAS/UBB/MRAS/WIPI1/CALCOCO2/C9orf72/PPP2CB/RRAGB/BCL2L1	3.51923088532532
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/566	54/9376	3.06766130087685	CDO1/SMS/SDS/BCAT1/DNMT1/SDSL/ENOPH1/LDHB/BCAT2/LACC1	3.86213659398118
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	21/566	173/9376	2.0108253845054	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/NFKBIA/HLA-DQB1/HLA-DMA/HLA-DQA1/IL1B/HLA-DQA2/HLA-DMB/CXCL10/TNFSF10/FADD/TRADD/SLC25A5/IL18/RAB11B/CDK6/IL1A/CALCOCO2	3.40126429299561
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/566	56/9376	2.95810196870268	EEF1A1/NFKBIA/CXCL2/ITGB2/CXCL3/IL1B/IL18/EEF1G/CD14/HSPA1A	3.7250084389726
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/566	224/9376	1.84881373043917	HLA-DRA/HLA-DRB1/HLA-DPA1/CDKN2A/HLA-B/HLA-DPB1/NFKBIA/HLA-DQB1/ITGB2/HLA-A/CDKN1A/HLA-DMA/HLA-DQA1/MSX2/KRAS/HLA-DQA2/HLA-DMB/SLC25A5/SPI1/MMP7/TGFBR1/ETS2/HLA-F/ZFP36/BCL2L1	3.25899953982879
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/566	88/9376	2.44715708319949	SERPINE2/SERPINE1/C1QA/C1QB/CD59/ITGB2/F5/CLU/SERPINA1/C1QC/PLAUR/C5AR1/SERPING1	3.45701932215129
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	18/566	144/9376	2.07067137809187	C1QA/C1QB/NFKBIA/ACADVL/CXCL2/CXCL3/LPIN2/IL1B/PRKAB2/LY96/FADD/TRADD/C1QC/CTNNB1/C5AR1/CD14/ADIPOR1/TCF7L1	3.28167403373109
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/566	79/9376	2.51625888983316	ATP6V0E1/CLTA/ATP6V1E1/ATP6V0D1/VAMP2/ATP6V1B1/ATP6V1D/ATP6V1H/ATP6V1G1/CLTB/SLC6A2/ATP6V1C1	3.43021538051494
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/566	180/9376	1.93262661955241	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DPB1/NFKBIA/HLA-DQB1/HLA-A/HLA-DMA/HLA-DQA1/IL1B/SP100/HLA-DQA2/HLA-DMB/FADD/TRADD/EIF2B1/HLA-F/BIRC3/BCL2L1	3.20221492976144
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/566	112/9376	2.21857647652701	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/NFKBIA/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB/LY96/SOCS1/BIRC3/HSPA1A/BCL2L1	3.28827725112019
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/566	51/9376	2.92330076907088	ATP6V0E1/ATP6V1E1/ATP6V0D1/PLCG2/ATP6V1B1/ATP6V1D/ATP6V1H/ATP6V1G1/ATP6V1C1	3.49071002022011
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	31/566	308/9376	1.66729383690514	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/CLTA/MT-ATP8/SOD1/COX7C/PSMD7/PSMB2/UQCRQ/NDUFAB1/UQCRC2/SLC25A5/BBC3/CLTB/RCOR1/WIPI1/POLR2C/MT-ND6/NDUFA13/PSMA3	3.01816247961004
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/566	75/9376	2.42958775029446	SERPINE1/CDKN2A/PMAIP1/CDKN1A/SESN1/GADD45B/BBC3/CDK6/GADD45G/SIAH1/BCL2L1	3.15052207722072
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	43/566	480/9376	1.48398115429918	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/SQSTM1/OPTN/MT-ATP8/UBA52/SOD1/COX7C/PSMD7/IL1B/PSMB2/MAP1LC3B/UQCRQ/KRAS/UBB/NDUFAB1/CAT/UQCRC2/FADD/SLC25A5/CTNNB1/IL1A/CALM2/WIPI1/CAMK2G/MT-ND6/PINK1/C9orf72/NDUFA13/PSMA3/BCL2L1/RAB5A	2.75903736567817
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/566	157/9376	1.89921451239	SERPINE1/CDKN2A/HLA-B/SQSTM1/HLA-A/CDKN1A/E2F4/GADD45B/KRAS/MRAS/SLC25A5/TGFBR1/CDK6/IL1A/CALM2/GADD45G/HLA-F/RAD1	2.87989812881048
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	19/566	170/9376	1.85142382041156	IGF2/GSTA3/CDKN2A/GSTT1/NFE2L2/CDKN1A/HMOX1/GADD45B/PLCG2/KRAS/BRD7/CTNNB1/TGFBR1/CDK6/EGFR/GADD45G/GSTM3/BCL2L1/TCF7L1	2.83949214314222
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	21/566	196/9376	1.77486118122161	HLA-B/NFKBIA/CXCL2/GNG5/HLA-A/CXCL3/CDKN1A/UBA52/PLCG2/MAP1LC3B/KRAS/UBB/FADD/TRADD/CTNNB1/CDK6/CALM2/HLA-F/ZFP36/RCAN1/TCF7L1	2.77866697188549
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/566	48/9376	2.76089517078916	HADHB/BCAT1/AUH/ACADS/BCAT2/ECHS1/MCEE/MCCC1	3.10002896726983
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	34/566	368/9376	1.53049623598095	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/SQSTM1/OPTN/MT-ATP8/SOD1/COX7C/PSMD7/PSMB2/MAP1LC3B/ANXA11/UQCRQ/NDUFAB1/CAT/UQCRC2/WIPI1/MT-ND6/PINK1/C9orf72/NDUFA13/PSMA3/BCL2L1/RAB5A	2.63146699318783
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	20/566	187/9376	1.77169743580053	GABARAPL1/GABARAPL2/CTSB/NFKBIA/CXCL2/CXCL3/CASP4/GBP1/GBP2/IL1B/GBP3/MAP1LC3B/GABARAP/FADD/IL18/TXN/IFI16/BIRC3/GPSM3/BCL2L1	2.70171562373057
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	35/566	388/9376	1.49429893264362	APOE/MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/MT-ATP8/COX7C/PSMD7/IL1B/PSMB2/UQCRQ/KRAS/NDUFAB1/UQCRC2/FADD/LPL/SLC25A5/CTNNB1/IL1A/CALM2/WIPI1/MT-ND6/PSENEN/RTN4/NDUFA13/PSMA3	2.52046054357913
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/566	32/9376	3.10600706713781	ACSS1/LDHB/ACADS/SUCLG1/ECHS1/MCEE	3.02464422605252
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/566	142/9376	1.86652067884338	TYROBP/SQSTM1/NFKBIA/TREM2/ACP5/PLCG2/IL1B/FCGR3A/NCF2/SPI1/SOCS1/TMEM64/TGFBR1/IL1A/JUND/FCGR1A	2.63714535448035
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/566	142/9376	1.86652067884338	GSTA3/GSTT1/SQSTM1/ASS1/NFE2L2/DUSP1/MMP9/HMOX1/IL1B/CTSL/NCF2/CTNNB1/TXN/IL1A/CALM2/GSTM3	2.63714535448035
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/566	73/9376	2.26922890749794	CDKN2A/CDKN1A/GADD45B/PLCG2/KRAS/FHIT/CDK6/EML4/EGFR/GADD45G	2.75928000617627
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/566	42/9376	2.76089517078916	SLC40A1/FTL/GPX4/LPCAT3/HMOX1/MAP1LC3B/FTH1	2.89887940560571
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/566	33/9376	3.01188564086091	VAMP8/STX4/STX7/VAMP2/VAMP7/SNAP23	2.93442481161992
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/566	43/9376	2.69668830635221	ACADVL/ECI1/HADHB/CPT2/ECI2/ACADS/ECHS1	2.82638657210219
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	13/566	109/9376	1.97568645249133	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/NFKBIA/HLA-DQB1/HLA-DMA/HLA-DQA1/IL1B/HLA-DQA2/HLA-DMB/TGFBR1/EBI3	2.5969275987781
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/566	133/9376	1.86827492760169	GABARAPL1/GABARAPL2/FOXO4/CDKN1A/FBXO32/GADD45B/PRKAB2/GABARAP/KRAS/TNFSF10/CAT/TGFBR1/EGFR/GADD45G/HOMER3	2.55612744895403
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/566	75/9376	2.20871613663133	GSTA3/CDKN2A/GSTT1/PMAIP1/CDKN1A/FADD/BBC3/GSTM3/BIRC3/BCL2L1	2.66376574139332
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/566	87/9376	2.09447219852971	MT-CYB/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/TNNC1/COX7C/UQCRQ/UQCRC2/CACNA2D3	2.5994757999026
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/566	87/9376	2.09447219852971	PMAIP1/CDKN1A/GADD45B/KRAS/CTNNB1/EREG/TGFBR1/BBC3/EGFR/GADD45G/TCF7L1	2.5994757999026
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/566	76/9376	2.17965408220197	CDKN2A/CDKN1A/GADD45B/PLCG2/KRAS/CDK6/CALM2/CAMK2G/EGFR/GADD45G	2.61713361933011
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/566	78/9376	2.12376551599166	C1QA/C1QB/ITGB2/IL1B/LY96/C1QC/IL1A/CALM2/SERPING1/CD14	2.52600456546991
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/566	216/9376	1.61052218296035	OLR1/NFKBIA/CCL3/CXCL2/VAV3/NFE2L2/CXCL3/MMP9/IL1B/KRAS/LY96/TNFSF10/NCF2/IL18/CD36/CALM2/CAMK2G/ABCG1/CD14/HSPA1A/BCL2L1	2.30084035903895
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/566	37/9376	2.68627638238946	CDKN1A/GADD45B/KRAS/CTNNB1/GADD45G/TCF7L1	2.60486566526289
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	13/566	116/9376	1.85646399415133	ACSS1/SDS/CAT/FBP1/SDSL/ACADS/SUCLG1/IDNK/ECHS1/MCEE/GCSH/IDH2/ALDOA	2.35254809466674
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/566	232/9376	1.57085414889728	FN1/TMSB4X/GSN/SCIN/VAV3/ITGB2/MYL12A/RGCC/ARPC2/BAIAP2/KRAS/PIP5K1B/MYH10/MRAS/CXCR4/EGFR/DIAPH2/ITGB6/SSH3/WASF2/MYL12B/BCAR1	2.23155166006227
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/566	93/9376	1.95934495991489	MYL12A/BAIAP2/PTPN1/SORBS1/CTNNB1/TGFBR1/PTPN6/EGFR/WASF2/MYL12B/TCF7L1	2.35655726061323
NA	NA	hsa03272	Virion - Hepatitis viruses	7/566	48/9376	2.41578327444052	TSG101/CHMP1B/EGFR/CHMP1A/CHMP4B/IST1/CLDN23	2.49246476164437
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/566	59/9376	2.2461520033539	GSTA3/GSTT1/SMS/GPX4/GSTK1/GSTM3/GSR/IDH2	2.43368787096383
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/566	168/9376	1.67625778226485	FTL/SQSTM1/IL1B/TNFSF10/CHMP5/FADD/GLUL/PARP1/TRADD/SLC25A5/IL1A/CHMP1B/FTH1/CAMK2G/CHMP1A/BIRC3/CHMP4B	2.24176539591903
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/566	94/9376	1.93850086459665	NFKBIA/CXCL2/CXCL3/MMP9/IL1B/CCL20/CXCL10/FADD/TRADD/JUND/S100A8	2.31784143028
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/566	160/9376	1.6565371024735	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DPB1/HLA-DQB1/ITGB2/HLA-A/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB/HLA-F/ALCAM/PTPRC/CLDN23	2.12301924979585
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/566	41/9376	2.42420063776609	CDKN2A/CDKN1A/MMP9/KRAS/EGFR/RPS6KA5	2.31639086048317
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/566	52/9376	2.22995379179125	APOE/APOC1/LIPA/CYP27A1/LPL/LRPAP1/CD36	2.25421447758307
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/566	31/9376	2.67183403624758	ACSS1/CAT/GLUL/MCEE/GCSH	2.36314437961585
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/566	298/9376	1.44530082766144	CSH1/CSH2/CCL3/CXCL2/CXCL3/IL1B/CCL20/CCL18/TNFRSF12A/CXCL10/CXCL9/TNFSF10/IL1RN/CXCL16/IL18/TGFBR1/CXCR4/TNFSF13B/GH2/IL1A/GDF15/CCL4/CXCR6/EBI3/CSF3R/CSF2RA	1.98003307439018
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/566	100/9376	1.82219081272085	CCL3/CXCL2/CXCL3/CCL20/CCL18/CXCL10/CXCL9/TNFSF10/IL18/CXCR4/CCL4	2.09506812398656
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/566	76/9376	1.96168867398177	OLR1/DBI/SCP2/CPT2/CYP27A1/LPL/SORBS1/CD36/FABP3	2.13356423546524
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/566	32/9376	2.58833922261484	GABARAPL1/GABARAPL2/GABARAP/WIPI1/PPP2CB	2.28117043558827
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/566	32/9376	2.58833922261484	PMAIP1/FADD/BBC3/BIRC3/BCL2L1	2.28117043558827
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/566	77/9376	1.9362121976963	CDKN2A/CDKN1A/GADD45B/KRAS/TGFBR1/CDK6/EGFR/GADD45G/BCL2L1	2.09077564990869
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/566	77/9376	1.9362121976963	CDKN2A/NFKBIA/CDKN1A/GADD45B/KRAS/TGFBR1/CDK6/GADD45G/BCL2L1	2.09077564990869
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/566	78/9376	1.9113889643925	FN1/CLTA/HCLS1/ELMO3/ARPC2/CTNNB1/CLTB/WASF2/BCAR1	2.04862371394516
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/566	103/9376	1.76911729390374	SERPINE1/C1QA/C1QB/NFKBIA/CCL3/PPP2R2B/IL1B/FADD/C1QC/TGFBR1/PPP2CB	1.98933058062043
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/566	116/9376	1.71365907152431	VAV3/ITGB2/MYL12A/MMP9/PLCG2/NCF2/CTNNB1/CXCR4/MYL12B/BCAR1/SIPA1/CLDN23	1.96028939969599
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/566	44/9376	2.25891423064568	STX4/VAMP2/DYNLL2/RAB11B/ARHGDIB/RAB5A	2.12149012983339
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/566	143/9376	1.62178457584818	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/C1QA/C1QB/HLA-DQB1/HLA-DMA/HLA-DQA1/FCGR3A/HLA-DQA2/HLA-DMB/C1QC/FCGR1A	1.89907643658509
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	15/566	157/9376	1.582678760325	MT-CYB/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/COX7C/IL1B/PRKAB2/UQCRQ/NDUFAB1/UQCRC2/IL1A/ADIPOR1/NDUFA13	1.86613477477973
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/566	93/9376	1.78122269083172	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/NFKBIA/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DQA2/HLA-DMB	1.91901357818007
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	13/566	133/9376	1.61917160392146	TYROBP/HLA-B/FCER1G/VAV3/ITGB2/HLA-A/PLCG2/FCGR3A/KRAS/TNFSF10/PTPN6/CD48/HCST	1.82278847641975
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/566	83/9376	1.79624505087488	NFKBIA/IL1B/CXCL10/TREX1/FADD/IL18/IFI16/CCL4/SAMHD1	1.84677387880154
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/566	59/9376	1.96538300293466	CDKN1A/GADD45B/KRAS/CTNNB1/EGFR/GADD45G/TCF7L1	1.88535660076253
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	18/566	204/9376	1.46165038453544	FN1/TIMP3/IGF2/VAV3/CDKN1A/MMP9/HCLS1/PDCD4/PLCG2/CTSL/CD44/KRAS/MRAS/CTNNB1/PLAUR/PTPN6/CAMK2G/EGFR	1.68967104521011
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/566	98/9376	1.69034398211581	GSN/SCIN/VAV3/ARPC2/PLCG2/FCGR3A/PIP5K1B/WASF2/FCGR1A/PTPRC	1.74123463321588
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/566	193/9376	1.45912594518391	NFKBIA/CCL3/CXCL2/VAV3/GNG5/CXCL3/PLCG2/CCL20/CCL18/KRAS/CXCL10/CXCL9/CXCL16/CXCR4/CCL4/CXCR6/BCAR1	1.63351865053003
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/566	38/9376	2.17965408220197	PNP/QPRT/SIRT2/NMRK1/SIRT5	1.84682369520002
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/566	75/9376	1.76697290930506	ASS1/SDS/BCAT1/GLUL/SDSL/BCAT2/IDH2/ALDOA	1.69025306973852
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/566	227/9376	1.38652885229059	CDKN2A/HLA-B/NFKBIA/CCL3/GNG5/HLA-A/CDKN1A/IL1B/KRAS/FADD/TRADD/CTNNB1/CXCR4/CDK6/CALM2/EGFR/HLA-F/CCL4/BCAR1	1.49421788915663
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/566	29/9376	2.28487876203241	RASSF6/WWC1/RASSF4/FRMD6	1.75643032983936
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/566	119/9376	1.53125278379903	NFKBIA/CXCL2/CXCL3/MMP9/IL1B/CCL20/CXCL10/FADD/TRADD/RPS6KA5/BIRC3	1.47824176128366
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	26/566	333/9376	1.29339233226159	SPP1/FN1/HLA-B/ATP6V0E1/HLA-A/PPP2R2B/CDKN1A/ATP6V1E1/ATP6V0D1/KRAS/FADD/ATP6V1B1/TRADD/ATP6V1D/CTNNB1/ATP6V1H/BCAP31/ATP6V1G1/CDK6/EGFR/HLA-F/ITGB6/ATP6V1C1/PPP2CB/HES2/TCF7L1	1.381721484086
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/566	93/9376	1.60310042174855	FN1/NFKBIA/CDKN1A/GADD45B/FHIT/CDK6/GADD45G/BIRC3/BCL2L1	1.48146989574691
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/566	68/9376	1.70525878195801	BCL2A1/KRAS/PIM1/SPI1/CD14/FCGR1A/TCF7L1	1.47938316207674
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/566	20/9376	2.48480565371025	CYB5R1/NPL/CMAS	1.68478855409876
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/566	109/9376	1.51975880960871	SPP1/NFKBIA/CCL3/IL1B/LY96/CXCL10/CXCL9/FADD/CCL4/CD14	1.3834116420643
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/566	57/9376	1.74372326576158	ACADVL/HADHB/SCP2/CPT2/ACADS/ECHS1	1.42748002309002
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/566	21/9376	2.36648157496214	BCAT1/PPCS/BCAT2	1.58890316917061
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/566	34/9376	1.94886717938059	PRKAB2/DBP/BHLHE41/SKP1	1.40485289770561
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/566	170/9376	1.36420702556641	MYL12A/PPP2R2B/HCLS1/ARPC2/PRKAB2/MYH10/SYNPO/NEDD4L/AMOT/PPP2CB/MYL6/NEDD4/MYL12B/CLDN23	1.21462773624672
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/566	142/9376	1.39989050913253	UBE2I/UBA52/UBB/SOCS1/NEDD4L/UBE2Q1/RHOBTB1/UBE2E1/SIAH1/BIRC3/NEDD4/SKP1	1.2170158476394
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/566	73/9376	1.58846023524856	CDKN2A/CDKN1A/GADD45B/KRAS/CDK6/EGFR/GADD45G	1.27930159166641
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/566	200/9376	1.3252296819788	NFKBIA/CASP4/HCLS1/ARPC2/IL1B/BAIAP2/TNFSF10/MYH10/FADD/TRADD/IL18/PTPN6/WASF2/NCK2/CLDN23/CYTH3	1.17837730456786
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/566	157/9376	1.371654925615	SERPINE1/RASSF6/ITGB2/PPP2R2B/CTNNB1/TGFBR1/BBC3/AMOT/BIRC3/PPP2CB/WWC1/FRMD6/TCF7L1	1.19029253875923
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/566	158/9376	1.3629735653263	ATP6V1E1/LPIN2/KRAS/ATP6V1B1/ATP6V1D/ATP6V1H/PRR5/ATP6V1G1/WDR59/LAMTOR5/ATP6V1C1/RRAGB/LAMTOR3	1.16624847406557
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	16/566	205/9376	1.29290700680858	CDKN2A/HLA-B/GSN/NFKBIA/SCIN/PMAIP1/HLA-A/CDKN1A/GTF2A2/SND1/ATP6V0D1/SP100/KRAS/TRADD/CDK6/HLA-F	1.07474205730842
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/566	106/9376	1.40649376625108	NFKBIA/FOLR1/CDKN1A/MMP9/KRAS/SPINT1/CTNNB1/EGFR/TCF7L1	1.06677506300787
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/566	136/9376	1.33984618582415	NFKBIA/IL1B/RAB9A/FADD/TRADD/BBC3/EIF3H/CDK6/IL1A/HSPA1A/BCL2L1	1.01186312246653
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	22/566	300/9376	1.21479387514723	IGF2/DUSP9/DUSP1/GADD45B/IL1B/DUSP2/KRAS/EFNA5/MRAS/TRADD/EREG/TGFBR1/IL1A/JUND/RASA1/EGFR/RPS6KA5/GADD45G/CD14/HSPA1A/CACNA2D3/LAMTOR3	0.958387579301653
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	13/566	168/9376	1.28184418643783	CSH1/CSH2/CDKN1A/PIM1/SOCS1/GH2/PTPN6/SOCS2/EGFR/CSF3R/BCL2L1/CSF2RA/CISH	0.934301328231991
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/566	125/9376	1.3252296819788	CTSD/FCER1G/ASAH1/PPP2R2B/KRAS/ORMDL1/TRADD/PPP2CB/ORMDL3/CERS2	0.927805067202534
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	12/566	156/9376	1.274259309595	NFKBIA/PPP2R2B/CDKN1A/KRAS/CXCL10/FADD/TRADD/CTNNB1/CDK6/EGFR/PPP2CB/CLDN23	0.875516059365254
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/566	41/9376	1.61613375851073	SDS/SDSL/GCSH/BPGM	1.00211063610252
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/566	28/9376	1.77486118122161	MOCS2/MOCS1/PCBD1	1.04075730457511
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/566	157/9376	1.26614300826	C1QA/C1QB/P2RY6/LIPA/DUSP2/C1QC/PTPN6/CD36/CAMK2G/BCAR1/GULP1/RAB5A	0.852371420748978
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/566	16/9376	2.07067137809187	HEXB/A4GALT	1.08638599800612
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/566	85/9376	1.36420702556641	NME4/PNP/TK2/DCTPP1/NME3/GMPR/LACC1	0.854933729430925
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/566	86/9376	1.3483441531761	CDKN1A/PLCG2/KRAS/EREG/CAMK2G/EGFR/NCK2	0.822537664483821
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/566	101/9376	1.31210859601861	FN1/SERPINE1/PLCG2/IL1B/KRAS/PIM1/TGFBR1/IL1A	0.799310204343011
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/566	17/9376	1.94886717938059	SCP2/CYP27A1	0.992478395252653
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/566	17/9376	1.94886717938059	MYH10/NRP2	0.992478395252653
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/566	73/9376	1.36153734449877	TSG101/ELL/CXCR4/SUPT4H1/CHMP4B/SAMHD1	0.785975453496456
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/566	103/9376	1.28663075920272	FN1/CXCL2/ITGB2/CXCL3/IL1B/PRDX1/CD14/RAB5A	0.741373700927059
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/566	59/9376	1.40384500209618	NME4/TK2/DCTPP1/NME3/NUDT2	0.788694060359931
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/566	31/9376	1.60310042174855	FBP1/IDNK/ALDOA	0.852484960288229
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/566	149/9376	1.22294685417507	MT-ND2/MT-ND5/MT-ND4L/MT-ND1/MT-ND3/MT-ND4/MGLL/GNG5/NDUFAB1/MT-ND6/NDUFA13	0.695296626486463
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/566	105/9376	1.26212350664647	FCER1G/NFKBIA/PLCG2/IL1B/KRAS/LSP1/MRAS/CALM2	0.684609983140216
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/566	46/9376	1.44046704562913	FTL/HMOX1/FTH1/FXN	0.759027332292458
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/566	46/9376	1.44046704562913	PSMB10/PSMD7/PSMB2/PSMA3	0.759027332292458
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/566	61/9376	1.35781729710942	SLC40A1/FTL/MT2A/HMOX1/FTH1	0.710625386566804
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/566	47/9376	1.40981881061574	ACSS1/LDHD/LDHB/ACYP2	0.713886502145482
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/566	184/9376	1.17037947457367	MYL12A/PLCG2/KRAS/EFNA5/DPYSL2/CXCR4/RASA1/CAMK2G/SSH3/NCK2/MYL12B/SEMA6D/SEMA3F	0.591598518646963
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/566	62/9376	1.33591701812379	SOD1/PRKAB2/KRAS/CAT/HSPA1A	0.672613584028952
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/566	33/9376	1.50594282043045	BCAT1/BCAT2/IDH2	0.737940137043171
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/566	138/9376	1.20038920469094	RHOQ/PRKAB2/KRAS/PTPN1/FBP1/SORBS1/SOCS1/SOCS2/CALM2/PPP1R3D	0.60107793465278
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/566	138/9376	1.20038920469094	FN1/NFKBIA/VAV3/ARPC2/IL1B/BAIAP2/PIP5K1B/IL18/WASF2/BCAR1	0.60107793465278
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/566	201/9376	1.15380693704622	HPGD/NUPR1/CDKN1A/MMP9/GADD45B/BCL2A1/SPINT1/SPI1/GADD45G/BIRC3/CD14/FCGR1A/BCL2L1/ETV6	0.558697612425749
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/566	63/9376	1.31471198609008	CDKN1A/GADD45B/CTNNB1/GADD45G/TCF7L1	0.635249974900503
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/566	110/9376	1.20475425634436	SERPINE1/CDKN1A/HMOX1/PLCG2/CAMK2G/LDHB/EGFR/ALDOA	0.547506188863729
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/566	110/9376	1.20475425634436	FBN1/E2F4/HAMP/TGIF1/TGFBR1/NOG/PPP2CB/SKP1	0.547506188863729
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/566	65/9376	1.274259309595	MGLL/LPIN2/LPL/DGKA/PNPLA2	0.562374723946474
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/566	50/9376	1.3252296819788	AOC1/SMS/CKMT1B/ALDH4A1	0.584431170223225
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/566	50/9376	1.3252296819788	ITGB2/IL1B/IL18/CD36	0.584431170223225
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/566	158/9376	1.15328532450687	CDKN2A/TFDP2/CDKN1A/CDKN1C/E2F4/GADD45B/CDK6/GADD45G/PPP2CB/SMC1B/SKP1	0.492511832485855
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/566	21/9376	1.57765438330809	DSE/CHST11	0.671678928674144
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/566	36/9376	1.38044758539458	GALNT11/GALNT18/B3GNT3	0.579666955850653
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/566	82/9376	1.21210031888305	GSTA3/GSTT1/NME4/TK2/NME3/GSTM3	0.488936898336275
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/566	67/9376	1.2362217182638	ACSS1/FBP1/LDHB/BPGM/ALDOA	0.491826143094072
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/566	22/9376	1.50594282043045	AOC1/HNMT	0.602171219348523
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/566	37/9376	1.34313819119473	ASS1/GLUL/ALDH4A1	0.530060731454355
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/566	37/9376	1.34313819119473	IL1B/IL18/APOL1	0.530060731454355
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	21/566	323/9376	1.0770055464998	TIMP3/CDKN2A/VIM/UBE2I/CDKN1A/MMP9/PDCD4/HMOX1/PLCG2/CD44/KRAS/EFNA5/PIM1/SOCS1/DNMT1/CDK6/EGFR/RPS6KA5/FOXP1/TP63/ZEB2	0.356970977034865
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/566	69/9376	1.20038920469094	FCER1G/VAV3/PLCG2/KRAS/ALOX5AP	0.42344782806531
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/566	23/9376	1.44046704562913	ASS1/GLUL	0.536053050558779
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/566	70/9376	1.18324078748107	NFKBIA/PRKAB2/TRADD/CD36/ADIPOR1	0.390027783537736
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/566	70/9376	1.18324078748107	GSTA3/GSTT1/GSTK1/GSTM3/SULT1A1	0.390027783537736
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/566	214/9376	1.08371586143126	HLA-B/NFKBIA/GNG5/HLA-A/PLCG2/KRAS/FADD/TRADD/CXCR4/CALM2/HLA-F/SAMHD1/BCL2L1/SKP1	0.313996923549011
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/566	55/9376	1.20475425634436	HEXB/ASAH1/PSAP/CERS2	0.386001443527044
NA	NA	hsa04382	Cornified envelope formation	14/566	217/9376	1.06873361449903	S100A10/S100A6/KRT7/S100A11/KRT8/PPP2R2B/DST/EPHX2/KRT23/COL17A1/S100A8/KRT18/PPP2CB/CLDN23	0.259645571555154
NA	NA	hsa04517	IgSF CAM signaling	19/566	299/9376	1.05264899488283	VAV3/ITGB2/MYL12A/ARPC2/PLCG2/BAIAP2/MYH10/NRP2/SORBS1/CTNNB1/DYNLL2/PTPN6/CD48/RASA1/PPFIA1/NCK2/MYL6/MYL12B/BCAR1	0.234509483712871
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/566	154/9376	1.07567344316461	RGS2/CDKN1A/PRKAB2/KRAS/CALM2/CAMK2G/EGFR/MYL6/CACNA2D3/RCAN1	0.239992238185218
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/566	122/9376	1.08625383768754	NFKBIA/VAV3/PPP2R2B/KRAS/PTPN6/NCK2/PPP2CB/PTPRC	0.243052165353537
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/566	122/9376	1.08625383768754	CSH1/CSH2/PLCG2/KRAS/SOCS1/GH2/SOCS2/BCAR1	0.243052165353537
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/566	10/9376	1.6565371024735	ETHE1	0.52648753938017
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/566	42/9376	1.18324078748107	AOC1/CAT/ECHS1	0.301660742733361
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/566	140/9376	1.06491670873296	SPP1/SERPINE1/GNG5/PRKAB2/MAP1LC3B/KRAS/MRAS/TGFBR1/CALM2	0.196148254773886
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/566	27/9376	1.22706452035074	ACADS/ECHS1	0.299470798937394
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/566	28/9376	1.18324078748107	HADHB/ECHS1	0.246120457042842
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/566	28/9376	1.18324078748107	B3GNT3/A4GALT	0.246120457042842
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/566	128/9376	1.03533568904594	NME4/PNP/FHIT/NME3/GMPR/NUDT2/PDE7A/LACC1	0.102023575190074
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/566	29/9376	1.14243938101621	CNGB1/CALM2	0.194714751596227
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/566	30/9376	1.10435806831567	SUCLG1/IDH2	0.145104095454273
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/566	30/9376	1.10435806831567	PIGC/PGAP2	0.145104095454273
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/566	30/9376	1.10435806831567	FOLR1/IL1B	0.145104095454273
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/566	117/9376	0.991090574129443	SMARCA1/SRCAP/BRD7/BCL7C/RBBP7/BCL7B/ZNHIT1	-0.0245791300302298
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/566	31/9376	1.06873361449903	ACADS/ECHS1	0.0971552506244192
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	14/566	238/9376	0.974433589690293	IGF2/GNG5/FOXO4/PLCG2/KRAS/EFNA5/MRAS/ETS2/CALM2/RASA1/EGFR/EXOC2/BCL2L1/RAB5A	-0.101260147530181
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/566	154/9376	0.968106098848148	NME4/MOCS2/PNPO/QPRT/BCAT1/NME3/PPCS/MOCS1/BCAT2	-0.101148942109598
NA	NA	hsa04518	Integrin signaling	9/566	154/9376	0.968106098848148	SPP1/FN1/FBN1/ITGB2/CTNNB1/EGFR/ITGB6/FERMT3/NCK2	-0.101148942109598
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/566	120/9376	0.966313309776207	NFKBIA/PLCG2/KRAS/CALM2/CAMK2G/RPS6KA5/ARHGDIB	-0.0941332802003221
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/566	51/9376	0.974433589690293	PLA2G7/PLD3/GDPD3	-0.046401959633316
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/566	104/9376	0.955694482196249	LPCAT3/LPIN2/CDIPT/PCYT2/PLD3/DGKA	-0.115157883500354
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/566	139/9376	0.953402648905611	CTSD/MMP9/KRAS/KRT23/CALM2/EGFR/KRT18/HSPA1A	-0.140284296014635
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/566	15/9376	1.10435806831567	HEXB	0.102521850882746
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/566	122/9376	0.950472107976597	PPP2R2B/PRKAB2/FBP1/RAB11B/CD36/PPP2CB/ADIPOR1	-0.139563197701326
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/566	71/9376	0.933260339421689	KRAS/SOCS1/SOCS2/CISH	-0.143074052606609
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/566	71/9376	0.933260339421689	KRAS/LDHB/EGFR/IDH2	-0.143074052606609
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/566	89/9376	0.930638821614325	SPP1/FN1/CD44/CD36/ITGB6	-0.166640148113356
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/566	89/9376	0.930638821614325	GABARAPL1/GABARAPL2/GNG5/GABARAP/GLUL	-0.166640148113356
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/566	107/9376	0.928899309798223	PPP4C/PRKAB2/FBP1/CALM2/CAMK2G/LDHB	-0.187480094590372
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/566	35/9376	0.946592629984856	FBP1/ALDOA	-0.0802314106007189
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/566	178/9376	0.930638821614325	CBY1/CTNNB1/MMP7/TBL1X/CAMK2G/CTNNBIP1/SIAH1/TLE6/SKP1/TCF7L1	-0.236802160782119
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/566	72/9376	0.920298390263055	NFKBIA/CXCL10/FADD/TRADD	-0.172069695392313
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/566	90/9376	0.920298390263055	SESN1/PRKAB2/KRAS/CAT/ADIPOR1	-0.192566132267244
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/566	90/9376	0.920298390263055	NFKBIA/KRAS/PTPN6/EML4/EGFR	-0.192566132267244
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/566	54/9376	0.920298390263055	RMI2/ERCC4/SLX1A	-0.148872788514117
Organismal Systems	Immune system	hsa04611	Platelet activation	7/566	126/9376	0.920298390263055	VAMP8/FCER1G/MYL12A/PLCG2/SNAP23/FERMT3/MYL12B	-0.22829026841469
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/566	91/9376	0.910185221139285	NFKBIA/VAV3/PLCG2/KRAS/PTPN6	-0.218214420239912
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/566	73/9376	0.907691562999177	GSTA3/GSTT1/GSTK1/GSTM3	-0.200676822843452
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/566	17/9376	0.974433589690293	CDO1	-0.0267414770243322
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/566	17/9376	0.974433589690293	GLUL	-0.0267414770243322
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/566	37/9376	0.895425460796486	CMAS/GALK1	-0.161540913148489
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/566	18/9376	0.920298390263055	HEXB	-0.0857862580719739
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/566	18/9376	0.920298390263055	PRDX1	-0.0857862580719739
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/566	148/9376	0.895425460796486	CDKN1A/GADD45B/KRAS/CTNNB1/CDK6/EGFR/GADD45G/TCF7L1	-0.325019130357641
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/566	38/9376	0.871861632880789	HEXB/GALK1	-0.200608785431628
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/566	38/9376	0.871861632880789	KRAS/NEDD4L	-0.200608785431628
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/566	149/9376	0.889415893945502	FCER1G/PLCG2/KRAS/PIP5K1B/MRAS/DGKA/EGFR/CYTH3	-0.344874818562533
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	11/566	203/9376	0.897630942227019	SPP1/FN1/VAV3/MYL12A/PIP5K1B/CTNNB1/EGFR/ITGB6/BIRC3/MYL12B/BCAR1	-0.373737716487273
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/566	150/9376	0.883486454652532	CDKN1A/GADD45B/KRAS/CTNNB1/TGFBR1/EGFR/GADD45G/TCF7L1	-0.364603825813255
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/566	19/9376	0.871861632880789	HEXB	-0.14170773965147
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/566	19/9376	0.871861632880789	GCSH	-0.14170773965147
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/566	59/9376	0.842307001257711	MGLL/ADRB1/PNPLA2	-0.307968480042666
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/566	78/9376	0.849506206396666	ISYNA1/CDIPT/PLCG2/PIP5K1B	-0.338280543678587
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/566	78/9376	0.849506206396666	BTG3/LSM1/CNOT6L/PARN	-0.338280543678587
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/566	79/9376	0.838752963277721	GSTA3/GSTT1/GSTK1/GSTM3	-0.364787352038596
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/566	60/9376	0.828268551236749	KRAS/CRH/PPP2CB	-0.338233499166857
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/566	20/9376	0.828268551236749	LIPA	-0.194861313015707
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/566	98/9376	0.845171991057907	CDIPT/PLCG2/PIP5K1B/DGKA/CALM2	-0.390518203020422
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/566	154/9376	0.860538754531687	ADRB1/TNNC1/PPP2R2B/CALM2/CAMK2G/RPS6KA5/PPP2CB/CACNA2D3	-0.442290122404414
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/566	80/9376	0.828268551236749	PLCG2/KRAS/EGFR/BCL2L1	-0.390978313828199
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/566	99/9376	0.83663490023914	CDKN2A/CDKN1A/MMP9/KRAS/EGFR	-0.414170346078265
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/566	99/9376	0.83663490023914	KRAS/PIP5K1B/DGKA/EGFR/WASF2	-0.414170346078265
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/566	155/9376	0.854986891599225	CDKN2A/CDKN1A/CTNNB1/CRH/CDK6/CAMK2G/EGFR/TCF7L1	-0.461413184049538
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/566	174/9376	0.856829535762154	NFE2L2/NSFL1C/BCAP31/AMFR/SVIP/HSPA4L/HSPA1A/SKP1/DNAJB2	-0.483162080249351
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/566	62/9376	0.801550210874273	PSENEN/CIR1/TLE6	-0.397360111908519
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/566	101/9376	0.820067872511633	KRAS/CTNNB1/CALM2/CAMK2G/TCF7L1	-0.460806230348179
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/566	63/9376	0.788827191654047	HPGD/GPX4/EPHX2	-0.426254884245303
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/566	63/9376	0.788827191654047	ERCC4/POLR2C/CETN2	-0.426254884245303
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/566	194/9376	0.853885104367783	DYNLRB1/TNNC1/MYL12A/DYNLT1/MYH10/KIFC3/DYNLRB2/DYNLL2/MYL6/MYL12B	-0.521233850713487
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/566	83/9376	0.798331133722168	CBX4/RBBP7/L3MBTL3/SKP1	-0.467741424578029
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/566	233/9376	0.853152155780342	FN1/VIM/PDLIM1/TNNC1/FBN1/CSRP2/MYH10/BGN/FMNL2/DIAPH2/ITGB6/FBN2	-0.575316825626269
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/566	65/9376	0.764555585756999	SPP1/KISS1/KRAS	-0.482783930507865
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/566	86/9376	0.770482373243488	CTNNB1/ITGB6/CACNA2D3/TCF7L1	-0.541955106606113
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/566	24/9376	0.690223792697291	GLCE	-0.385129982234728
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/566	67/9376	0.741733030958283	KRAS/CALM2/CAMK2G	-0.537725524164249
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/566	47/9376	0.704909405307872	SOCS1/SOCS2	-0.51403495155403
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/566	69/9376	0.720233522814564	CTSB/ADRB1/CALM2	-0.591182081451774
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/566	109/9376	0.759879404804357	NFKBIA/PRKAB2/PTPN1/CD36/PPP1R3D	-0.639114952458697
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/566	26/9376	0.637129654797499	SLC52A3	-0.469610983660602
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/566	49/9376	0.676137592846326	GALNT11/GALNT18	-0.576094183911187
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/566	130/9376	0.764555585756999	NFKBIA/GNG5/MMP9/KRAS/TGFBR1/EGFR	-0.685155301899746
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/566	27/9376	0.61353226017537	SCP2	-0.509704477960879
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/566	93/9376	0.712489076332687	KRAS/CALM2/CAMK2G/EGFR	-0.706248516418881
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/566	93/9376	0.712489076332687	LYZ/ADRB1/VAMP2/CALM2	-0.706248516418881
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/566	212/9376	0.781385425695046	VAV3/ITGB2/KRAS/EFNA5/MRAS/CTNNB1/CALM2/EGFR/BCAR1/SIPA1	-0.816038034868693
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/566	115/9376	0.720233522814564	CDKN1A/JUND/EGFR/NR4A2/MAFB	-0.765105901661264
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	18/566	362/9376	0.8236924818929	SPP1/CSH1/FN1/CSH2/IGF2/GNG5/PPP2R2B/CDKN1A/KRAS/EFNA5/EREG/GH2/CDK6/EGFR/ITGB6/PPP2CB/CSF3R/BCL2L1	-0.867106096847904
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/566	53/9376	0.625108340556037	CLTA/CLTB	-0.693700121655028
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/566	97/9376	0.683108083494226	GNG5/CALM2/CAMK2G/RPS6KA5	-0.795156000122774
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/566	138/9376	0.720233522814564	CALM2/SLK/CAMK2G/PPP2CB/SMC1B/SKP1	-0.839174228726843
NA	NA	hsa04981	Folate transport and metabolism	1/566	31/9376	0.534366807249516	FOLR1	-0.65817445903939
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/566	99/9376	0.669307920191312	PLCG2/IL1B/CALM2/CAMK2G	-0.838385024342391
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/566	99/9376	0.669307920191312	TNNC1/PRKAB2/ITGB6/CACNA2D3	-0.838385024342391
NA	NA	hsa04081	Hormone signaling	10/566	219/9376	0.756409635832648	CSH1/CSH2/SLC40A1/IGF2/ADRB1/GNG5/HAMP/CRH/GH2/ADIPOR1	-0.924509662622298
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/566	32/9376	0.517667844522968	GALK1	-0.69272472626874
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/566	34/9376	0.487216794845147	POLR2C	-0.759205279001036
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/566	60/9376	0.552179034157833	PLCG2/KRAS	-0.882005324987921
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/566	105/9376	0.631061753323237	ADRB1/TNNC1/ITGB6/CACNA2D3	-0.963587013116727
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/566	36/9376	0.460149195131527	FGGY	-0.822540830025437
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/566	36/9376	0.460149195131527	AGL	-0.822540830025437
NA	NA	hsa04519	Cadherin signaling	19/566	404/9376	0.779064478886051	KRT7/VIM/KRT8/NFKBIA/VAV3/ARPC2/CDH8/KRAS/KRT23/MRAS/CTNNB1/EGFR/PSENEN/KRT18/LHFPL2/WWC1/TMC4/TMC5/TCF7L1	-1.15058178737654
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/566	37/9376	0.447712730398243	FAHD1	-0.853142557751333
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/566	63/9376	0.525884794436031	SMYD2/ECHS1	-0.957007313818205
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/566	38/9376	0.435930816440394	PTPRC	-0.88308627897551
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/566	195/9376	0.679604965117333	ITGB2/CASP4/PLCG2/FCGR3A/NCF2/SLC25A5/C5AR1/FCGR1A	-1.14594556680203
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/566	133/9376	0.622758309200563	GNG5/PPP2R2B/CALM2/CAMK2G/PPP2CB	-1.1105674137174
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/566	89/9376	0.558383292968595	ADRB1/KRAS/EGFR	-1.06098361045498
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/566	39/9376	0.424753103198333	GCSH	-0.912407419528387
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/566	69/9376	0.480155681876376	CALM2/CAMK2G	-1.09849703621032
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/566	70/9376	0.473296314992428	CDKN1A/KRAS	-1.1210881249126
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/566	43/9376	0.385241186621744	CD36	-1.02408088080092
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/566	163/9376	0.609768258579202	NFKBIA/CDKN1A/MMP9/KRAS/FADD/TGFBR1	-1.27386016858734
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/566	44/9376	0.376485705107613	HEXB	-1.05073037560771
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/566	44/9376	0.376485705107613	GTF2A2	-1.05073037560771
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/566	44/9376	0.376485705107613	PARP1	-1.05073037560771
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/566	45/9376	0.368119356105222	ABCG1	-1.07691918482542
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/566	98/9376	0.507103194634744	CALM2/CAMK2G/NR4A2	-1.24321933751494
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/566	144/9376	0.575186493914409	DUSP9/ISL1/KRAS/CTNNB1/KLF4	-1.30207968628421
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/566	144/9376	0.575186493914409	PSMD7/PSMB2/SLC25A5/WIPI1/PSMA3	-1.30207968628421
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/566	122/9376	0.54312691884377	PLCG2/KRAS/CTNNB1/RCAN1	-1.28740928686591
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/566	76/9376	0.435930816440394	CALM2/CAMK2G	-1.25142145158887
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/566	217/9376	0.610704922570875	GSTA3/GSTT1/ADRB1/KRAS/EPHX2/EGFR/KLF4/GSTM3	-1.47058675175765
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/566	52/9376	0.31856482739875	HSD17B1	-1.24890954592282
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/566	86/9376	0.385241186621744	VAMP2/CAMK2G	-1.4516169539994
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/566	115/9376	0.432140113688739	GNG5/KRAS/CAMK2G	-1.55298431286127
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/566	115/9376	0.432140113688739	GNG5/DUSP1/KRAS	-1.55298431286127
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/566	254/9376	0.586961965443366	ADRB1/TNNC1/PLCG2/SLC25A5/CXCR4/CALM2/CAMK2G/ORAI3/EGFR	-1.69148351436043
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/566	116/9376	0.428414767881077	GNG5/GLUL/HOMER3	-1.57003885504079
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/566	166/9376	0.498956958576355	ADRB1/RGS2/CNGB1/SLC25A5/CALM2	-1.65084068471647
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/566	91/9376	0.364074088455714	GNG5/PDE7A	-1.54504866418895
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/566	66/9376	0.250990470071742	HSD17B1	-1.54771278558197
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/566	226/9376	0.513086713155508	NFKBIA/ADRB1/VAV3/CNGB1/CRH/CALM2/CAMK2G	-1.87802425876517
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/566	68/9376	0.243608397422573	DHRS4L2	-1.58664171140502
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/566	103/9376	0.321657689800679	PPP2R2B/PPP2CB	-1.75454005845969
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/566	103/9376	0.321657689800679	COL17A1/SLC7A7	-1.75454005845969
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/566	134/9376	0.370866515479141	MYH10/CALM2/MYL6	-1.85916577967229
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/566	108/9376	0.306766130087685	EEF1A1/UBE2I	-1.83655753378357
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/566	75/9376	0.220871613663133	GSR	-1.71704128105326
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/566	191/9376	0.433648456144895	GNG5/KRAS/CRH/CALM2/SLC29A3	-2.00432937578019
NA	NA	hsa04082	Neuroactive ligand signaling	5/566	199/9376	0.416215352380276	ADRB1/GNG5/TAC3/P2RY6/SLC6A2	-2.10976819818357
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/566	102/9376	0.162405598281716	RAB27B	-2.15578877195725
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/566	110/9376	0.150594282043045	KRAS	-2.27128312612719
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/566	370/9376	0.447712730398243	CSH1/CSH2/KISS1/ADRB1/TAC3/P2RY6/CRH/C5AR1/GH2/CHRNB1	-2.74729833545934
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/566	243/9376	0.20451075339179	CTNNBL1/SART1/HSPA1A	-3.18446603264198
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/566	183/9376	0.0905211531406283	REXO2	-3.14916500607434
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/566	449/9376	0.147575688416347	RGS2/CNGB1/CALM2/CAMK2G	-4.69172048108392