category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	83/1202	205/9376	3.15818351527941	B2M/HLA-A/HLA-B/HLA-E/NFKBIA/HLA-DRA/TNFAIP3/HLA-DRB1/HLA-DPA1/VIM/CD44/HLA-DPB1/HLA-F/HLA-C/GADD45B/STAT1/JAK1/CD3E/RBPJ/JUN/RUNX3/NFKB1/TAP1/CD3G/CD3D/CD247/MAP2K3/HLA-DMA/CDKN1B/IRF7/PIK3R1/BCL2L11/RELB/NFKB2/ISG15/TAPBP/STAT3/ITGAL/HLA-DQB1/IRF9/EIF2AK2/CCND2/HLA-DQA2/HLA-DQA1/TRAF5/JAK3/CD58/PDIA3/OAS2/CIR1/CASP8/OAS1/CXCL10/CASP3/USP7/CDKN1A/HLA-DMB/RB1/STAT2/MAP2K7/ICAM1/TAPBPL/TNF/FAS/RIPK1/LYN/CYCS/TAB2/NFKBIB/SNW1/IFNAR2/TRAF3/PIK3CA/TBK1/PIK3CD/NFKBIE/BCL2/DDB2/BAK1/IRAK1/IFNAR1/SAP30/IRF3	11.9805708036365
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	57/1202	109/9376	4.07907310445893	NFKBIA/HLA-DRA/HLA-DRB1/HLA-DPA1/IL2RG/HLA-DPB1/STAT1/JAK1/HSP90AA1/CD3E/RORA/JUN/LCK/NFKB1/LAT/CD3G/CD3D/CD247/TGFB1/IFNG/HLA-DMA/TGFBR2/HSP90AB1/STAT3/HLA-DQB1/HLA-DQA2/HLA-DQA1/TBX21/NFATC3/STAT5A/IL4R/IL2RA/NFATC2/IRF4/JAK3/EBI3/CD4/IL27RA/ZAP70/IL1B/STAT5B/FOXP3/IL21R/PRKCQ/HLA-DMB/HIF1A/NFKBIB/IL12RB1/SMAD4/PPP3CC/NFKBIE/NFATC1/RARA/MAPK1/IFNGR1/STAT6/FOS	12.3989304245889
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	73/1202	180/9376	3.16346829358477	B2M/HLA-A/HLA-B/HLA-E/CD74/NFKBIA/HLA-DRA/CCL5/BIRC3/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/HLA-C/STAT1/SP100/JAK1/BST2/NFKB1/TAP1/TNFRSF14/IFNG/HLA-DMA/SRSF2/IRF7/PIK3R1/TNFSF14/TAPBP/HLA-DQB1/IRF9/EIF2AK2/BIRC2/HLA-DQA2/SRSF7/HLA-DQA1/ZC3HAV1/TRAF5/PDIA3/OAS2/LTA/EIF4EBP1/CASP8/IL1B/OAS1/SOCS3/POU2F2/FASLG/CASP3/HLA-DMB/STAT2/IFIH1/TAPBPL/TNF/FAS/SRSF4/SRSF5/CYCS/TAB2/IFNAR2/PTPN11/TRAF3/PIK3CA/TBK1/PIK3CD/PML/TSC2/DAXX/BCL2/IFNGR1/BAK1/IRAK1/IFNAR1/IRF3	11.2384873593001
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	49/1202	93/9376	4.10985275436996	NFKBIA/HLA-DRA/HLA-DRB1/HLA-DPA1/IL2RG/HLA-DPB1/STAT1/JAK1/CD3E/RBPJ/JUN/RUNX3/LCK/NFKB1/LAT/CD3G/CD3D/CD247/IFNG/HLA-DMA/HLA-DQB1/HLA-DQA2/STAT4/HLA-DQA1/TBX21/NFATC3/STAT5A/IL4R/IL2RA/NFATC2/MAF/JAK3/CD4/ZAP70/STAT5B/PRKCQ/HLA-DMB/NOTCH1/NFKBIB/IL12RB1/PPP3CC/NFKBIE/NFATC1/MAPK1/IFNGR1/STAT6/FOS/MAML1/MAML2	11.5573344412665
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	56/1202	122/9376	3.58048061973214	PTPRC/NFKBIA/CD3E/JUN/LCK/NFKB1/FYN/LAT/CD3G/CD3D/CD247/IFNG/PAK2/PIK3R1/ICOS/CTLA4/PPP2R5C/NFATC3/NFATC2/PDCD1/LCP2/GRB2/CD4/CD28/ZAP70/PTPN6/KRAS/CD8A/RASGRP1/PPP2R2B/ITK/PRKCQ/MAP2K7/TNF/MAP3K8/CBLB/NCK2/GRAP2/MALT1/NFKBIB/SOS2/PTPN11/VAV1/NCK1/PPP2R2A/PIK3CA/PPP3CC/PIK3CD/NFKBIE/NFATC1/PPP2R3C/PPP2R5A/MAPK1/FOS/SOS1/CARD11	11.0011053799948
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	42/1202	82/9376	3.99529239884745	B2M/HLA-A/HLA-B/HLA-E/CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/HLA-C/CTSB/CTSS/HSP90AA1/HSPA1A/TAP1/KLRD1/IFNG/PSME1/HLA-DMA/KLRC2/HSP90AB1/HSPA1B/TAPBP/HLA-DQB1/PSME2/LGMN/HLA-DQA2/HLA-DQA1/PDIA3/CD4/HSPA5/CREB1/HSPA8/KIR3DL2/CD8A/HLA-DMB/TAPBPL/TNF/KLRC3/RFX5/KLRC4	10.4463692256163
Human Diseases	Infectious disease: viral	hsa05162	Measles	56/1202	136/9376	3.21190173240677	NFKBIA/TNFAIP3/IL2RG/STAT1/JAK1/CD3E/JUN/NFKB1/HSPA1A/MX1/CD3G/CD3D/MSN/CDKN1B/IRF7/PIK3R1/ADAR/HSPA1B/STAT3/IRF9/EIF2AK2/CCND2/STAT5A/IL2RA/JAK3/OAS2/CD28/CASP8/IL1B/STAT5B/OAS1/FASLG/HSPA8/CSNK2B/CASP3/SLAMF1/STAT2/IFIH1/MX2/CD46/FAS/CYCS/CBLB/TAB2/NFKBIB/IFNAR2/TRAF3/PIK3CA/TBK1/PIK3CD/BCL2/BAK1/FOS/IRAK1/IFNAR1/IRF3	9.96368187406192
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	64/1202	173/9376	2.88567224183201	NFKBIA/HLA-DRA/CCL5/HLA-DRB1/HLA-DPA1/HLA-DPB1/STAT1/DNAJB1/JAK1/TNFSF10/NFKB1/MX1/IFNG/HLA-DMA/IRF7/PIK3R1/ADAR/PRKCB/HLA-DQB1/CASP1/IRF9/EIF2AK2/HLA-DQA2/HLA-DQA1/EP300/HNRNPUL1/OAS2/CREBBP/CASP8/IL1B/OAS1/SOCS3/RSAD2/FASLG/NXT1/CXCL10/CASP3/HLA-DMB/STAT2/IFIH1/ICAM1/PABPN1/MX2/TNF/FAS/CYCS/DNAJC3/NFKBIB/IFNAR2/TRAF3/KPNA6/CALCOCO2/PIK3CA/TBK1/IL18/PIK3CD/PML/MAPK1/IFNGR1/BAK1/TRIM25/IFNAR1/RAB11B/IRF3	9.59942243866141
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	52/1202	133/9376	3.04975416911663	HLA-A/HLA-B/HLA-E/HLA-C/CD48/ITGB2/TNFSF10/LCK/FYN/LAT/CD247/KLRD1/HCST/IFNG/FCGR3A/KLRC2/SH2D1A/PIK3R1/PRKCB/ITGAL/NFATC2/ICAM2/LCP2/GRB2/RAC2/ZAP70/PTK2B/FASLG/PTPN6/KRAS/KIR3DL2/CASP3/LAT2/ICAM1/TNF/FAS/SH3BP2/SOS2/IFNAR2/PTPN11/VAV1/MICB/GZMB/PIK3CA/PPP3CC/PIK3CD/NFATC1/MAPK1/KLRC3/IFNGR1/SOS1/IFNAR1	9.12938826696235
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	45/1202	105/9376	3.34299976230093	NFKBIA/TNFAIP3/BIRC3/CCL4/GADD45B/LCK/NFKB1/CYLD/CFLAR/LAT/RELB/NFKB2/TNFSF14/PRKCB/CXCL2/BCL2A1/BIRC2/CXCL3/ATM/TRAF5/LTA/ZAP70/IL1B/TRAF1/CSNK2B/LY96/PRKCQ/LTB/TNFSF13B/ICAM1/TNF/PLAU/RIPK1/LYN/TAB2/MALT1/CD14/TRAF3/XIAP/CCL4L1/BCL2/TRIM25/IRAK1/CARD11/PARP1	9.25814884804212
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	58/1202	163/9376	2.77557853475292	NFKBIA/STAT1/JAK1/JUN/NFKB1/MAP2K3/TGFB1/IRF7/TGFBR2/PIK3R1/PRKCB/STAT3/EGR2/STAT4/NFATC3/STAT5A/NFATC2/MMP9/EP300/JAK3/GRB2/CREBBP/CASP8/PTK2B/STAT5B/FASLG/CREB1/YWHAZ/KRAS/CASP3/DDX3X/CDKN1A/RB1/STAT2/IFIH1/MAP2K7/TNF/FAS/ATF2/CYCS/TAB2/SOS2/TRAF3/SMAD4/PIK3CA/TBK1/PIK3CD/YWHAQ/NFATC1/MAPK1/BCL2/DDB2/STAT6/FOS/SOS1/IRAK1/IFNAR1/IRF3	8.76907345691072
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	63/1202	187/9376	2.62791959924191	NFKBIA/CCL5/TNFAIP3/BIRC3/STAT1/GBP2/CTSB/GBP5/JAK1/HSP90AA1/GBP4/IFI16/GBP1/JUN/NFKB1/CYBA/GABARAPL1/NAMPT/IRF7/CARD16/HSP90AB1/CASP4/CXCL2/CASP1/IRF9/BIRC2/CXCL3/GBP3/PKN1/TRAF5/MAP1LC3B/GPSM3/OAS2/PKN2/CASP8/IL1B/OAS1/ITPR2/RBCK1/GSDMD/NLRP1/STAT2/TANK/GABARAPL2/TNF/RIPK1/TAB2/NFKBIB/IFNAR2/TRAF3/XIAP/ITPR1/NEK7/TBK1/IL18/TRPM7/MAPK1/BCL2/ATG12/RIPK3/IFNAR1/GABARAP/IRF3	8.62263861554922
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	40/1202	90/9376	3.46681456831207	NFKBIA/STAT1/JAK1/CD3E/JUN/LCK/NFKB1/LAT/CD3G/BATF/CD3D/CD247/MAP2K3/IFNG/PIK3R1/EML4/STAT3/NFATC3/NFATC2/PDCD1/CD4/CD28/ZAP70/PTPN6/KRAS/CSNK2B/RASGRP1/PRKCQ/HIF1A/NFKBIB/PTPN11/PIK3CA/PPP3CC/PIK3CD/NFKBIE/NFATC1/MAPK1/RPS6KB1/IFNGR1/FOS	9.01703955886678
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	47/1202	119/9376	3.08080370251262	NFKBIA/IRF1/CCL5/TNFAIP3/BIRC3/TNFRSF1B/JUNB/JUN/NFKB1/CYLD/CFLAR/MAP2K3/PIK3R1/CXCL2/BCL3/BIRC2/CCL20/CXCL3/MMP9/TRAF5/LTA/CASP8/IL1B/SOCS3/CREB1/TRAF1/CXCL10/CASP3/MLKL/MAP2K7/ICAM1/ITCH/TNF/FAS/RIPK1/MAP3K8/ATF2/TAB2/TRAF3/XIAP/PIK3CA/RHBDF2/PIK3CD/MAPK1/FOS/RIPK3/IL18R1	8.75971579954257
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	70/1202	224/9376	2.43760399334443	B2M/HLA-A/HLA-B/HLA-E/NFKBIA/HLA-DRA/ZFP36/HLA-DRB1/HLA-DPA1/IL2RG/HLA-DPB1/HLA-F/HLA-C/JAK1/ITGB2/ETS1/CD3E/JUN/LCK/NFKB1/CD3G/CD3D/TGFB1/HLA-DMA/TLN1/TSPO/TGFBR2/PIK3R1/RELB/NFKB2/ITGAL/HLA-DQB1/EGR2/CCND2/HLA-DQA2/HLA-DQA1/NFATC3/STAT5A/IL2RA/NFATC2/ATM/EP300/GPS2/JAK3/ADCY3/CD4/LTA/CREBBP/STAT5B/CREB1/PRKACB/KRAS/CDKN1A/HLA-DMB/RB1/ICAM1/TNF/ATF2/XIAP/SMAD4/PIK3CA/PPP3CC/PIK3CD/ELK4/NFATC1/MAD1L1/MAPK1/ATR/FOS/ETS2	8.3507566731113
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	64/1202	196/9376	2.54704743794356	HLA-A/HLA-B/HLA-E/NFKBIA/ZFP36/CLEC2B/HLA-F/HLA-C/STAT1/JAK1/JUN/NFKB1/GNG2/IRF7/PIK3R1/CXCL2/STAT3/IRF9/EIF2AK2/NFATC3/CXCL3/NFATC2/PREX1/EP300/LEF1/MAP1LC3B/MAPKAPK2/CREBBP/CASP8/CREB1/KRAS/ITPR2/CASP3/CDKN1A/RB1/STAT2/HIF1A/MAP2K7/ICAM1/FAS/LYN/CCR1/CYCS/IFNAR2/TRAF3/ITPR1/MICB/PIK3CA/PPP3CC/TBK1/PIK3CD/TCF7/CALM2/PIK3C3/NFATC1/MAPK1/IFNGR1/BAK1/FOS/CCR4/IFNAR1/BECN1/UBB/IRF3	8.39326395735613
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	52/1202	142/9376	2.85645989079234	NFKBIA/JUND/JUNB/STAT1/JAK1/JUN/LCK/NFKB1/CYBA/FYN/CYLD/FOSL2/TGFB1/IFNG/FCGR3A/SOCS1/TGFBR2/PIK3R1/RELB/NFKB2/IRF9/ACP5/TREM2/NFATC2/LCP2/GRB2/SQSTM1/IL1B/SOCS3/CREB1/ITPR2/NCF1/STAT2/MAP2K7/TNF/NCF2/CAMK4/TAB2/IFNAR2/ITPR1/SIRPG/PIK3CA/PPP3CC/PIK3CD/NFATC1/MAPK1/IFNGR1/FOS/IFNAR1/ATP2A2/FCGR2A/FCGR1A	8.54781989872076
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	36/1202	78/9376	3.60015359017023	NFKBIA/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/STAT1/JAK1/ITGB2/JUN/NFKB1/CYBA/ITGA4/TGFB1/IFNG/HLA-DMA/FCGR3A/ITGB1/PRKCB/HLA-DQB1/HLA-DQA2/HLA-DQA1/IL1B/PTPN6/HLA-DMB/NCF1/TNF/NCF2/EEF1A1/TAB2/NFKBIB/MAPK1/IFNGR1/FOS/IRAK1/FCGR2A/FCGR1A	8.84243931812652
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	67/1202	214/9376	2.44216026249086	B2M/HLA-A/HLA-B/HLA-E/CXCR4/NFKBIA/TNFRSF1B/HLA-F/HLA-C/APOBEC3G/BST2/CD3E/JUN/APOBEC3C/NFKB1/TAP1/CD3G/GNG2/CD3D/CD247/MAP2K3/GNAI2/PAK2/PIK3R1/PRKCB/TAPBP/SAMHD1/NFATC3/NFATC2/ATM/TRAF5/APOBEC3D/PDIA3/CD4/RAC2/CASP8/PTK2B/AP1S2/FASLG/KRAS/ITPR2/CASP3/FBXW11/MAP2K7/TAPBPL/TNF/FAS/LIMK1/RIPK1/CYCS/TAB2/CUL5/ITPR1/PIK3CA/PPP3CC/TBK1/PIK3CD/CALM2/NFATC1/MAPK1/RPS6KB1/BCL2/ATR/BAK1/FOS/IRAK1/IRF3	8.18362693486409
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	50/1202	138/9376	2.82620752851528	FN1/NFKBIA/JUN/LCK/NFKB1/ITGA4/LAT/MAP2K3/ROCK1/ITGB1/PIK3R1/WIPF1/ARF6/CASP1/RHOG/ARPC2/NFATC3/NFATC2/RPS6KA3/PKN1/LCP2/CD4/RAC2/PKN2/ZAP70/PTK2B/IL1B/WASF2/CD8A/WAS/MAP2K7/TNF/LIMK1/TAB2/VAV1/PIK3CA/ACTR2/TBK1/IL18/PIK3CD/NFATC1/MAPK1/WIPF3/GIT2/RPS6KA1/FOS/IRAK1/ELMO2/FCGR2A/IRF3	8.28745624353173
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	49/1202	137/9376	2.78990004493727	NFKBIA/BIRC3/CTSD/TUBA4A/GADD45B/CTSB/CTSS/JUN/TNFSF10/NFKB1/CFLAR/PMAIP1/MCL1/SPTAN1/PIK3R1/BCL2L11/CTSZ/BCL2A1/BIRC2/ATM/CAPN2/CASP8/FASLG/DDIT3/TRAF1/KRAS/ITPR2/CASP3/TUBA1A/CTSH/TNF/LMNB1/FAS/RIPK1/CYCS/CTSC/XIAP/ITPR1/GZMB/PIK3CA/PIK3CD/MAPK1/DAXX/BCL2/BAK1/FOS/PARP4/PARP1/EIF2AK3	8.09276881822887
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	63/1202	205/9376	2.39717543930847	HLA-A/HLA-B/HLA-E/NFKBIA/REL/HLA-F/HLA-C/SP100/JAK1/RBPJ/JUN/NFKB1/CHD4/PMAIP1/CDKN1B/IRF7/PIK3R1/NFKB2/STAT3/IRF9/EIF2AK2/EGR2/CCND2/RASA2/STAT5A/GTF2B/UBE3A/EP300/TRAF5/JAK3/GRB2/MAPKAPK2/CREBBP/CASP8/STAT5B/CREB1/PRKACB/YWHAZ/TRAF1/KRAS/CASP3/DDX3X/USP7/CDKN1A/RB1/RBL2/LYN/ATF2/UBR4/HDAC7/SNW1/TRAF3/PIK3CA/PIK3CD/YWHAQ/MAD1L1/HDAC3/MAPK1/BAK1/ACTN4/CCR4/GTF2E2/IRF3	7.75604074316631
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	31/1202	66/9376	3.66379266878435	HLA-DRA/HLA-DRB1/HLA-DPA1/IL2RG/HLA-DPB1/STAT1/RORA/JUN/NFKB1/TGFB1/IFNG/HLA-DMA/STAT3/HLA-DQB1/HLA-DQA2/STAT4/HLA-DQA1/TBX21/IL4R/MAF/IL1B/FOXP3/IL21R/HLA-DMB/TNF/IL12RB1/IL18/NFATC1/IFNGR1/STAT6/IL18R1	8.32756635639329
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	66/1202	227/9376	2.26793816473279	B2M/HLA-A/HLA-B/HLA-E/CXCR4/NFKBIA/CCL5/HLA-F/HLA-C/CCL4/JAK1/AKAP13/CCL3/NFKB1/TAP1/GNG2/PTGER4/GNAI2/ROCK1/PIK3R1/PRKCB/TAPBP/STAT3/IL10RA/NFATC3/NFATC2/TRAF5/ADCY3/PDIA3/GRB2/RAC2/EIF4EBP1/CASP8/PTK2B/IL1B/FASLG/CREB1/PRKACB/KRAS/ITPR2/CASP3/CDKN1A/RB1/GNA13/TAPBPL/TNF/FAS/RIPK1/ATF2/CCR1/CYCS/SOS2/ITPR1/PIK3CA/PPP3CC/TBK1/PIK3CD/CALM2/CCL4L1/NFATC1/MAPK1/TSC2/RPS6KB1/BAK1/SOS1/IRF3	7.41557350983138
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	63/1202	216/9376	2.2750970604548	NFKBIA/CCL5/NFE2L2/HSP90AA1/JUN/CCL3/TNFSF10/NFKB1/HSPA1A/CYBA/MAP2K3/IRF7/PIK3R1/HSP90AB1/HSPA1B/CXCL2/STAT3/CASP1/RAP1A/NFATC3/RAP1B/CXCL3/NFATC2/MMP9/HSP90B1/CASP8/IL1B/HSPA5/POU2F2/FASLG/DDIT3/HSPA8/KRAS/CASP3/LY96/NCF1/TANK/MAP2K7/ICAM1/TNF/FAS/NCF2/LYN/CYCS/TAB2/CD14/TRAF3/ITPR1/VAV1/XBP1/PIK3CA/PPP3CC/TBK1/IL18/PIK3CD/CALM2/NFATC1/MAPK1/BCL2/FOS/IRAK1/EIF2AK3/IRF3	7.27014275459231
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	69/1202	248/9376	2.17025387794536	PTPRC/NFKBIA/BIRC3/TUBA4A/HSP90AA1/JUN/TNFSF10/NFKB1/GCC2/RHOH/FLNA/MAP2K3/HSP90AB1/CASP4/ARF6/CASP1/BIRC2/RHOG/ARPC2/CYTH1/PKN1/STX10/LEF1/HSP90B1/ABI1/CASP8/IL1B/SNX9/CYTH4/NCKAP1L/DNM2/CASP3/GSDMD/LY96/MLKL/TUBA1A/DYNC1H1/ARL8A/MAP2K7/TNF/RIPK1/CYCS/KIF5B/TAB2/KPNA3/DYNC1LI2/CD14/RAB5A/PIK3CA/ACTR2/IL18/PIK3CD/CYFIP2/TCF7/DCTN1/PIK3C3/EXOC2/RHOB/MAPK1/BCL2/VPS41/TUBB2A/BAK1/FOS/IRAK1/RIPK3/ELMO2/KPNA4/CYTH2	7.16207177511443
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	23/1202	45/9376	3.98683675355888	HLA-A/HLA-B/HLA-E/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/HLA-C/KLRD1/IFNG/HLA-DMA/HLA-DQB1/HLA-DQA2/HLA-DQA1/CD28/IL1B/FASLG/KIR3DL2/HLA-DMB/TNF/FAS/GZMB	7.70148021890741
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	22/1202	44/9376	3.90016638935108	HLA-A/HLA-B/HLA-E/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/HLA-C/IFNG/HLA-DMA/HLA-DQB1/HLA-DQA2/HLA-DQA1/LTA/CD28/IL1B/FASLG/HLA-DMB/TNF/FAS/GZMB	7.39405103181627
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	56/1202	200/9376	2.18409317803661	NFKBIA/TUBA4A/JUN/TNFSF10/NFKB1/FYN/EZR/ROCK1/ITGB1/PAK2/WIPF1/CASP4/ARF6/NCL/CASP1/ARPC2/CYTH1/ABI1/MYH9/CASP8/IL1B/FASLG/ARHGEF2/CYTH4/NCKAP1L/PTPN6/WASF2/CASP3/HCLS1/TUBA1A/F2R/MYO5A/GNA13/TNF/FAS/RIPK1/MYO1F/CYCS/TAB2/NCK2/NFKBIB/PTPN11/NCK1/MYO1G/ACTR2/IL18/CYFIP2/MAPK1/WIPF3/TUBB2A/LPAR2/BAK1/FOS/IRAK1/CYTH2/FCGR2A	6.49074772410119
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	38/1202	112/9376	2.64654147848823	NFKBIA/HLA-DRA/BIRC3/HLA-DRB1/HLA-DPA1/HLA-DPB1/STAT1/JAK1/NFKB1/HSPA1A/MAP2K3/TGFB1/IFNG/HLA-DMA/SOCS1/GNAI2/ITGB1/HSPA1B/STAT3/HLA-DQB1/IL10RA/BIRC2/HLA-DQA2/HLA-DQA1/CASP8/HSPA8/CASP3/LY96/HLA-DMB/TNF/CYCS/TAB2/NFKBIB/XIAP/MAPK1/BCL2/IFNGR1/IRAK1	6.72206904722684
Human Diseases	Immune disease	hsa05330	Allograft rejection	20/1202	39/9376	4.0001706557447	HLA-A/HLA-B/HLA-E/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/HLA-C/IFNG/HLA-DMA/HLA-DQB1/HLA-DQA2/HLA-DQA1/CD28/FASLG/HLA-DMB/TNF/FAS/GZMB	7.19938068266645
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	47/1202	156/9376	2.35010026025001	NFKBIA/STAT1/JAK1/NFKB1/MX1/CFLAR/IFNG/IRF7/CD81/PIK3R1/STAT3/IRF9/EIF2AK2/GRB2/OAS2/CASP8/OAS1/SOCS3/RSAD2/FASLG/YWHAZ/CXCL10/KRAS/CASP3/PPP2R2B/CDKN1A/RB1/STAT2/MX2/TNF/FAS/RIPK1/CYCS/SOS2/IFNAR2/TRAF3/PIAS1/PPP2R2A/PIK3CA/TBK1/PIK3CD/YWHAQ/MAPK1/BAK1/SOS1/IFNAR1/IRF3	6.52053777130511
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	65/1202	250/9376	2.02808652246256	HLA-A/HLA-B/HLA-E/CXCR4/IL2RG/HLA-F/HLA-C/SMAP2/HSPA1A/SH3KBP1/ARAP2/TGFBR2/WIPF1/VPS37B/GIT1/HSPA1B/ARF6/BIN1/IGF2R/ARPC2/IL2RA/CYTH1/EHD4/ACAP2/RAB11FIP1/SMAP1/SH3GLB1/CYTH4/HSPA8/EPS15/DNM2/ARFGAP3/AGAP2/CHMP1B/RABEP1/GRK6/USP8/VPS4B/ITCH/RAB22A/CAPZA1/ARFGEF1/ACAP1/EEA1/CBLB/KIF5B/CHMP4A/ARAP1/WWP1/PDCD6IP/RAB5A/RAB35/ACTR2/CLTB/ARRB2/PML/SMURF2/WIPF3/GIT2/SNX1/RAB11B/AP2B1/ZFYVE16/CYTH2/ASAP1	6.3180054083567
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	51/1202	181/9376	2.19788382162326	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/CTSD/HLA-DPB1/STAT1/JAK1/ITGB2/CTSS/NFKB1/LSP1/TGFB1/IFNG/HLA-DMA/FCGR3A/PLK3/HLA-DQB1/IL10RA/HLA-DQA2/HLA-DQA1/EP300/LAMP1/CREBBP/CASP8/IL1B/CREB1/VDR/CASP3/CORO1A/HLA-DMB/TNF/ATP6V0B/TCIRG1/EEA1/CYCS/MALT1/CD14/RAB5A/PPP3CC/IL18/CALM2/PIK3C3/HSPA9/MAPK1/BCL2/IFNGR1/RFX5/IRAK1/FCGR2A/FCGR1A	6.2402023894805
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	46/1202	157/9376	2.28544782051146	HLA-A/HLA-B/HLA-E/HLA-F/HLA-C/GADD45B/ZFP36L2/ETS1/NFKB1/SERPINE1/MAP2K3/TGFB1/ZFP36L1/RASSF5/TGFBR2/PIK3R1/CCND2/NFATC3/NFATC2/ATM/CAPN2/SQSTM1/MAPKAPK2/EIF4EBP1/RAD50/KRAS/ITPR2/FBXW11/CDKN1A/RB1/RBL2/SIRT1/HIPK1/ITPR1/PIK3CA/PPP3CC/PIK3CD/TRPM7/CALM2/NFATC1/MAPK1/RAD9A/TSC2/NBN/ATR/HIPK3	6.22849222013387
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	53/1202	193/9376	2.14206029674204	CXCR4/NFKBIA/CCL5/CCL4/STAT1/XCL2/XCL1/CCL3/NFKB1/GNG2/GNAI2/ROCK1/PIK3R1/PRKCB/CXCL2/STAT3/RAP1A/DOCK2/CXCR3/CCL20/RAP1B/CXCL3/PREX1/JAK3/ADCY3/GRB2/RAC2/PTK2B/STAT5B/CCL18/PRKACB/CXCL10/KRAS/CXCL16/ITK/WAS/NCF1/GRK6/STAT2/CXCL9/CXCR6/LYN/CCR1/NFKBIB/SOS2/VAV1/PIK3CA/PIK3CD/ARRB2/CCL4L1/MAPK1/SOS1/CCR4	6.14746339501053
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	36/1202	109/9376	2.57625669755301	SPP1/NFKBIA/CCL5/CCL4/STAT1/JAK1/JUN/CCL3/NFKB1/MAP2K3/IRF7/PIK3R1/IRF9/CASP8/IL1B/CXCL10/LY96/STAT2/CXCL9/MAP2K7/TNF/RIPK1/MAP3K8/TAB2/CD14/IFNAR2/TRAF3/PIK3CA/TBK1/PIK3CD/CCL4L1/MAPK1/FOS/IRAK1/IFNAR1/IRF3	6.34733131082523
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	34/1202	105/9376	2.52582204262737	NFKBIA/IRF1/STAT1/JUN/NFKB1/CYLD/LSP1/PLK3/PIK3R1/RELB/NFKB2/CASP1/IRF9/BCL3/EGR2/NFATC3/NFATC2/MAPKAPK2/CASP8/IL1B/KRAS/ITPR2/STAT2/TNF/CBLB/MALT1/PTPN11/ITPR1/PIK3CA/PPP3CC/PIK3CD/CALM2/NFATC1/MAPK1	6.02914597498517
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	30/1202	87/9376	2.6897699236904	GADD45B/JUN/PMAIP1/TGFB1/TGFBR2/PIK3R1/BCL2L11/LEF1/AREG/GRB2/RAC2/KRAS/CASP3/CDKN1A/RALGDS/CYCS/SOS2/SMAD4/PIK3CA/EREG/PIK3CD/TCF7/MAPK1/RPS6KB1/BCL2/DDB2/APC/BAK1/FOS/SOS1	6.07188134385936
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	70/1202	300/9376	1.82007764836384	DUSP2/JUND/GADD45B/DUSP4/DUSP1/STK4/JUN/NFKB1/HSPA1A/PTPN7/FLNA/MAP2K3/TGFB1/DUSP5/PAK2/TGFBR2/RELB/NFKB2/HSPA1B/PRKCB/DUSP10/RAP1A/RASA2/TAOK3/NFATC3/RAP1B/RPS6KA3/NR4A1/AREG/MAP3K2/FLT3LG/IGF2/GRB2/MAPKAPK2/RAC2/IL1B/FASLG/DDIT3/PRKACB/HSPA8/KRAS/RASGRP1/CASP3/DUSP8/MAX/MAP2K7/TNF/FAS/CDC25B/MAP3K8/DUSP16/MAP4K1/ATF2/TAB2/MAP3K11/CD14/SOS2/MAP4K4/PPP3CC/EREG/ELK4/ARRB2/NFATC1/MAPK1/DAXX/RPS6KA1/FOS/SOS1/IRAK1/MAP3K4	5.53590863952207
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	46/1202	168/9376	2.13580540369226	FTL/TNFAIP3/BIRC3/STAT1/JAK1/HSP90AA1/TNFSF10/CYLD/CFLAR/IFNG/HSP90AB1/STAT3/CASP1/IRF9/EIF2AK2/BIRC2/STAT4/STAT5A/CAPN2/GLUL/TRAF5/JAK3/ZBP1/SQSTM1/CASP8/IL1B/STAT5B/FASLG/RBCK1/CHMP1B/MLKL/STAT2/VPS4B/TNF/FAS/RIPK1/CHMP4A/IFNAR2/XIAP/TRPM7/BCL2/IFNGR1/STAT6/RIPK3/IFNAR1/PARP1	5.69634745152911
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	39/1202	133/9376	2.28731562683748	GADD45B/STK4/TNFSF10/TGFB1/GABARAPL1/KLF2/PLK3/CDKN1B/TGFBR2/PIK3R1/BCL2L11/STAT3/CCND2/IL7R/PRKAG2/ATM/EP300/GRB2/CREBBP/FASLG/KRAS/AGAP2/USP7/CDKN1A/SGK1/GABARAPL2/RBL2/SIRT1/S1PR4/SOS2/SMAD4/PIK3CA/PIK3CD/MAPK1/ATG12/BCL6/S1PR1/SOS1/GABARAP	5.7335676426955
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	31/1202	95/9376	2.54537174883965	HLA-DRA/CCL5/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGB2/JUN/CCL3/TGFB1/IFNG/HLA-DMA/CTLA4/CXCL2/ITGAL/HLA-DQB1/ACP5/HLA-DQA2/HLA-DQA1/CCL20/CXCL3/CD28/IL1B/LTB/TNFSF13B/HLA-DMB/ICAM1/TNF/ATP6V0B/TCIRG1/IL18/FOS	5.80521007397979
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	30/1202	91/9376	2.57153827869302	NFKBIA/JUN/NFKB1/IFITM1/CD81/PIK3R1/PRKCB/NFATC3/NFATC2/CD72/GRB2/RAC2/PTPN6/KRAS/PIK3AP1/LYN/DAPP1/MALT1/NFKBIB/SOS2/VAV1/PIK3CA/PPP3CC/PIK3CD/NFKBIE/NFATC1/MAPK1/FOS/SOS1/CARD11	5.77663944263131
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	61/1202	253/9376	1.88071264624835	NFKBIA/CCL5/CD44/CAST/JUN/NFKB1/FNBP1/ROCK1/ITGB1/TNIP1/TLN1/PIK3R1/CASP4/ARF6/CASP1/ARPC2/CYTH1/ATM/CAPN2/TRAF5/MAP1LC3B/SQSTM1/IL1B/ARHGEF2/CYTH4/ITPR2/WASF2/RBCK1/DIAPH1/HCLS1/FBXW11/PRKCQ/TNF/RIPK1/CYCS/CAPNS1/TAB2/MALT1/NFKBIB/CD14/U2AF1L4/ITPR1/CALCOCO2/PIK3CA/UBE2D3/ACTR2/TBK1/IL18/PIK3CD/PIK3C3/MAPK1/RPS6KB1/BCL2/ATG12/CBX3/ACTN4/BECN1/ELMO2/UBB/CYTH2/IRF3	5.44560593562527
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	45/1202	168/9376	2.08937485143808	CSH1/IL2RG/STAT1/JAK1/IFNG/MCL1/SOCS1/CSH2/PIK3R1/STAT3/IL10RA/IRF9/CCND2/IL7R/STAT4/STAT5A/IL4R/IL2RA/EP300/JAK3/GRB2/CREBBP/IL27RA/STAT5B/SOCS3/PTPN6/IL21R/SOCS4/CDKN1A/STAT2/OSM/PTPN2/SOS2/IFNAR2/PTPN11/IL12RB1/PIAS1/PIK3CA/PIK3CD/BCL2/IFNGR1/STAT6/SOS1/IFNAR1/PIM1	5.46348664883668
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	32/1202	103/9376	2.42340435843174	NFKBIA/CCL5/CD3E/C1QB/C1QA/JUN/CCL3/NFKB1/CFLAR/SERPINE1/CD3G/CD3D/CD247/TGFB1/IFNG/GNAI2/TGFBR2/PIK3R1/C1QC/CASP8/IL1B/FASLG/PPP2R2B/TNF/FAS/PPP2R2A/PIK3CA/PIK3CD/MAPK1/IFNGR1/FOS/IRAK1	5.57002736851422
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	74/1202	333/9376	1.73340728415604	SPP1/HLA-A/FN1/HLA-B/HLA-E/IRF1/HLA-F/HLA-C/STAT1/JAK1/OASL/RBPJ/NFKB1/MX1/ITGA4/CHD4/PTGER4/ITGB1/CDKN1B/PIK3R1/ISG15/LFNG/PPP2R5C/IRF9/EIF2AK2/CCND2/UBE3A/ATM/EP300/GRB2/CREBBP/EIF4EBP1/CASP8/FASLG/CREB1/PRKACB/KRAS/CASP3/PPP2R2B/CDKN1A/RB1/STAT2/MX2/TNF/RBL2/FAS/ATP6V0B/TCIRG1/NOTCH1/UBR4/DLG3/SOS2/IFNAR2/TRAF3/PPP2R2A/PIK3CA/TBK1/PIK3CD/TCF7/PPP2R3C/PPP2R5A/MAPK1/MFNG/TSC2/RPS6KB1/APC/ATR/HES6/BAK1/SOS1/IFNAR1/MAML1/MAML2/IRF3	5.22554540516892
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	25/1202	73/9376	2.67134684202129	CXCR4/APOBEC3G/BST2/APOBEC3C/MX1/MLLT3/MDFIC/SAMHD1/EP300/APOBEC3D/SUPT5H/CD4/RANBP2/CREBBP/ELL2/VPS4B/MX2/PSIP1/CHMP4A/PDCD6IP/SERINC3/FEZ1/ELL/AFF4/CCNT1	5.49714332148306
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	27/1202	83/9376	2.53745765090311	YAF2/AUTS2/YY1/USP16/EP300/ASXL2/OGT/CREBBP/KDM2A/ASXL1/CSNK2B/PHF1/KDM2B/PCGF5/USP7/MAX/BCOR/MTF2/SUZ12/CBX6/PHF19/UBE2D3/JARID2/SFMBT2/CBX3/EZH1/PHC3	5.39491734117005
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	27/1202	83/9376	2.53745765090311	NFKBIA/CCL5/CCL4/IFI16/NFKB1/IRF7/ADAR/CASP1/SAMHD1/ZBP1/CASP8/IL1B/CXCL10/CASP3/POLR3GL/GSDMD/MLKL/PCBP1/RIPK1/TREX1/NFKBIB/POLR3E/TBK1/IL18/CCL4L1/RIPK3/IRF3	5.39491734117005
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	21/1202	56/9376	2.92512479201331	NFKBIA/ITGB2/NFKB1/HSPA1A/NFKB2/HSPA1B/CLK1/CXCL2/CASP1/CLK4/CXCL3/CASP8/IL1B/HSPA8/CASP3/TNF/CYCS/EEF1A1/CD14/IL18/HBS1L	5.54071101782122
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	30/1202	100/9376	2.34009983361065	HLA-DRA/CD2/HLA-DRB1/HLA-DPA1/CD44/HLA-DPB1/CD37/CD3E/CD7/ITGA4/CD3G/CD3D/HLA-DMA/CD38/HLA-DQB1/IL7R/HLA-DQA2/HLA-DQA1/IL4R/IL2RA/FLT3LG/CD4/CD9/IL1B/CD8A/HLA-DMB/CD5/TNF/CD14/FCGR1A	5.16627284391358
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	23/1202	70/9376	2.56296648443071	HLA-A/HLA-B/HLA-E/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/HLA-C/ITGB2/FYN/HLA-DMA/ITGAL/HLA-DQB1/HLA-DQA2/HLA-DQA1/RAC2/CD28/CASP8/CASP3/HLA-DMB/ICAM1/CYCS	5.03312500134063
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	32/1202	116/9376	2.15181593895232	CXCR4/ITGB2/CYBA/ITGA4/RHOH/EZR/MSN/GNAI2/ROCK1/ITGB1/RASSF5/PIK3R1/PRKCB/ITGAL/RAP1A/CD99/RAP1B/MMP9/RAC2/PTK2B/ITK/SIPA1/NCF1/ICAM1/NCF2/ARHGAP35/PTPN11/VAV1/PIK3CA/PIK3CD/TXK/ACTN4	4.78660004620383
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	32/1202	117/9376	2.13342434973051	BPTF/CHD4/RSF1/EPC1/SMARCA5/BAZ1A/BAZ1B/SMARCC2/YY1/MEAF6/BAZ2B/INO80D/CHD3/GATAD2B/BAZ2A/ING3/ARID1A/EP400/SRCAP/INO80/BCL7B/SMARCD1/PBRM1/DPF2/EPC2/BRD9/GATAD2A/CHRAC1/ARID2/SMARCC1/PHF6/SMARCE1	4.73068447527449
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	39/1202	155/9376	1.96266437657667	HLA-A/HLA-B/HLA-E/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/TUBA4A/HLA-C/ITGB2/CTSS/CYBA/TAP1/HLA-DMA/FCGR3A/ITGB1/HLA-DQB1/HLA-DQA2/HLA-DQA1/LAMP1/MSR1/CORO1A/TUBA1A/DYNC1H1/HLA-DMB/NCF1/NCF2/ATP6V0B/TCIRG1/EEA1/DYNC1LI2/CD14/RAB5A/PIK3C3/TUBB2A/MARCO/FCGR2A/FCGR1A	4.63417355369522
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/1202	54/9376	2.74456153324706	HLA-A/HLA-B/HLA-E/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/HLA-C/HLA-DMA/CTLA4/HLA-DQB1/HLA-DQA2/HLA-DQA1/CD28/FASLG/HLA-DMB/FAS/GZMB	4.93002564297435
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	22/1202	68/9376	2.52363707546246	NFKB1/PIK3R1/BCL2A1/STAT3/STAT5A/LEF1/GRB2/EIF4EBP1/STAT5B/KRAS/CD14/SOS2/PIK3CA/PIK3CD/TCF7/PML/RARA/MAPK1/RPS6KB1/SOS1/PIM1/FCGR1A	4.83535491082945
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	47/1202	201/9376	1.82395841094031	REL/BIRC3/HPGD/DDX5/GADD45B/KMT2A/NFKB1/NCOR1/NR4A3/CDKN1B/TGFBR2/JMJD1C/FUS/NFKBIZ/BCL2A1/BCL11B/MLLT3/BIRC2/CCND2/MMP9/MAF/ATM/KLF3/DDIT3/TRAF1/ZEB1/CDKN1A/MAX/PLAU/RUNX2/FUT8/ATF1/CD14/EWSR1/FLI1/GZMB/ELK4/KDM6A/PML/RARA/TAF15/DDB2/BCL6/BAK1/ETV6/CCNT1/FCGR1A	4.52815035503417
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	41/1202	169/9376	1.8923884256023	CTSD/CTSB/DDIT4/CFLAR/GABARAPL1/PIK3R1/OPTN/TAX1BP1/RB1CC1/BIRC6/MAP1LC3B/SQSTM1/LAMP1/SH3GLB1/PRKACB/KRAS/PRKCQ/TANK/HIF1A/GABARAPL2/NRBF2/UVRAG/ITPR1/CALCOCO2/PIK3CA/ATG2A/TBK1/PIK3CD/PIK3C3/MAPK1/TSC2/RPS6KB1/BCL2/VPS41/VMP1/RAB39B/ATG12/BECN1/GABARAP/UBB/EIF2AK3	4.48909467602247
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	22/1202	72/9376	2.38343501571455	NFKBIA/NFKB1/CYLD/IRF7/ADAR/ISG15/RNF125/CASP8/ZNFX1/CXCL10/DDX3X/IFIH1/TANK/TNF/RIPK1/NFKBIB/TRAF3/TBK1/ATG12/TRIM25/OTUD5/IRF3	4.51867094334171
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	23/1202	77/9376	2.32996953130065	NFKBIA/GADD45B/NFKB1/TGFB1/CDKN1B/TGFBR2/PIK3R1/STAT5A/GRB2/STAT5B/KRAS/CDKN1A/RB1/SOS2/PTPN11/SMAD4/PIK3CA/PIK3CD/CTBP1/MAPK1/DDB2/BAK1/SOS1	4.49354904075823
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	54/1202	250/9376	1.68487188019967	CTSD/CTSB/CTSS/LAPTM5/PSAP/CD68/VPS13C/CTSA/CTSZ/LGMN/ACP5/IGF2R/LIPA/IDS/HEXB/NCOA7/LAMP1/ASAH1/AP1S2/HEXA/VPS13A/LITAF/GGA2/BLOC1S6/CTSH/ARL8A/GPR155/BLOC1S2/ATP6V0B/TCIRG1/AP3B1/PPT1/TPP1/CTSC/TFEB/AP3M2/AP5M1/MCOLN2/CLTB/SPG11/GNPTG/AP3D1/VPS41/OSBP/DTNBP1/ENTPD4/NPC1/SLC15A3/CLCN7/CLN8/AP2B1/AP4B1/NEU1/LAPTM4A	4.20881331346359
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	22/1202	73/9376	2.35078522097873	GADD45B/STK4/RASSF5/PIK3R1/PRKCB/EML4/STAT3/STAT5A/JAK3/GRB2/STAT5B/KRAS/CDKN1A/RB1/KIF5B/SOS2/PIK3CA/PIK3CD/MAPK1/DDB2/BAK1/SOS1	4.44280012357045
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	27/1202	100/9376	2.10608985024958	CXCR4/CCL5/TNFRSF1B/IL2RG/CCL4/XCL2/XCL1/CCL3/TNFSF10/TNFRSF14/TNFSF14/CXCL2/IL10RA/CXCR3/CCL20/IL2RA/CXCL3/LTA/CCL18/CXCL10/CXCL9/TNF/CCR1/IL18/CCL4L1/CCR4/IL18R1	4.26413153181027
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	40/1202	174/9376	1.79317994912693	DNAJB1/NFE2L2/HSP90AA1/DNAJA1/HSPA1A/HSPH1/HSP90AB1/DNAJC1/HSPA1B/SEC62/UBXN4/CAPN2/HSP90B1/PDIA3/HSPA5/DDIT3/HSPA8/DNAJB2/PPP1R15A/MAP2K7/HERPUD1/DNAJB11/DNAJA2/RRBP1/SEL1L/MBTPS1/DNAJC3/HYOU1/SVIP/XBP1/UBXN2A/TRAM1/NPLOC4/UBE2D3/RPN1/BCL2/ERLEC1/BAK1/UBXN1/EIF2AK3	4.04972741550622
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	37/1202	157/9376	1.83829498606357	DUSP2/DUSP4/C1QB/C1QA/TGFB1/PTGER4/DUSP5/CASP1/NFATC3/C1QC/NFATC2/LIPA/MAPKAPK2/GPR132/CREB1/PTPN6/CASP3/DUSP8/HIF1A/CD47/SGK1/DUSP16/SIRT1/ATP8A1/ODC1/PTPN11/SIRPG/RAB5A/DNMT3A/ADAM10/NFATC1/MAPK1/VPS41/NR1H2/S1PR1/ATP2A2/CPT1A	4.06186366771128
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	14/1202	38/9376	2.87380681320606	PTPRC/IL2RG/CD3E/LCK/TAP1/ORAI1/CD3D/ICOS/IL7R/JAK3/CD4/ZAP70/CD8A/RFX5	4.43823437278529
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	60/1202	298/9376	1.57053680108097	CSH1/CXCR4/CCL5/TNFRSF1B/IL2RG/CCL4/XCL2/XCL1/TNFRSF9/CCL3/TNFSF10/TGFB1/TNFSF9/TNFRSF14/IFNG/CSH2/TNFRSF18/TGFBR2/TNFSF14/CXCL2/IL10RA/TNFRSF4/IL7R/CXCR3/CCL20/IL4R/IL2RA/CXCL3/IL16/IL1RN/CD27/EBI3/TNFSF12/CD4/LTA/IL27RA/IL1B/FASLG/CCL18/CXCL10/IL21R/CXCL16/LTB/TNFSF13B/CXCL9/TNF/FAS/CXCR6/TNFRSF25/OSM/CCR1/IFNAR2/CD70/IL12RB1/IL18/CCL4L1/IFNGR1/CCR4/IFNAR1/IL18R1	3.83810861700754
Genetic Information Processing	Transcription	hsa03040	Spliceosome	51/1202	243/9376	1.6371068794807	DDX5/HSPA1A/RBM25/PRPF38B/HNRNPU/SRSF2/HSPA1B/FUS/ACIN1/SF3B2/DDX46/SRSF7/SF1/U2SURP/CCDC12/SF3B1/THOC2/SLU7/SMNDC1/HSPA8/PRPF40A/CDC40/CDC5L/DDX39B/TRA2B/PCBP1/SRSF4/SRSF5/RBM22/DHX38/SNRNP200/SNW1/PRPF6/SF3A1/U2AF1L4/BCAS2/SYF2/SRSF10/CWC25/CASC3/RBM17/SNRNP27/PRPF8/AQR/TCERG1/WBP11/DHX8/SNIP1/CRNKL1/SF3A2/DDX42	3.8585955396232
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	37/1202	160/9376	1.80382695507488	HLA-A/HLA-B/HLA-E/PTPRC/HLA-DRA/CD2/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-F/HLA-C/ITGB2/TIGIT/ITGA4/CD6/HLA-DMA/ITGB1/ICAM3/SPN/ICOS/CTLA4/SELPLG/ITGAL/HLA-DQB1/CD99/HLA-DQA2/HLA-DQA1/ICAM2/SELL/PDCD1/CD58/GLG1/CD4/CD28/CD8A/HLA-DMB/ICAM1	3.93252850336943
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	25/1202	94/9376	2.07455659008036	NFKBIA/TNFAIP3/JUND/HSP90AA1/JUN/NFKB1/IFNG/HSP90AB1/CXCL2/CCL20/CXCL3/MMP9/TRAF5/HSP90B1/CASP8/IL1B/CXCL10/CASP3/S100A8/TNF/TAB2/TRAF3/TBK1/MAPK1/FOS	4.01506880518412
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	26/1202	101/9376	2.00800645788373	FN1/STAT1/JUN/NFKB1/SERPINE1/TGFB1/CDKN1B/TGFBR2/PIK3R1/PRKCB/STAT3/STAT5A/IL1B/STAT5B/KRAS/CASP3/DIAPH1/ICAM1/TNF/SMAD4/PIK3CA/PIK3CD/NFATC1/MAPK1/BCL2/PIM1	3.90559852052134
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	12/1202	32/9376	2.92512479201331	BIRC3/PMAIP1/BCL2L11/BIRC2/BIRC6/CASP8/CASP3/CYCS/XIAP/BCL2/BAK1/BECN1	4.18300146392074
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	23/1202	86/9376	2.08613551058314	JUN/CDKN1B/PAK2/PIK3R1/PRKCB/STAT5A/AREG/GRB2/EIF4EBP1/STAT5B/KRAS/CDKN1A/MAP2K7/CBLB/NCK2/SOS2/NCK1/PIK3CA/EREG/PIK3CD/MAPK1/RPS6KB1/SOS1	3.88012696639509
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	25/1202	98/9376	1.98988081089341	PTPRC/LAT/FCGR3A/PIK3R1/PRKCB/ARF6/BIN1/ARPC2/RAC2/DNM2/WASF2/WAS/NCF1/LIMK1/LYN/VAV1/PIK3CA/ACTR2/PIK3CD/MAPK1/RPS6KB1/MARCKS/ASAP1/FCGR2A/FCGR1A	3.7773681535031
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	21/1202	77/9376	2.12736348510059	GADD45B/STAT1/JAK1/NFKB1/TGFB1/TGFBR2/PIK3R1/STAT3/RAC2/KRAS/CDKN1A/RB1/RALGDS/ARHGEF6/SMAD4/PIK3CA/PIK3CD/MAPK1/RPS6KB1/DDB2/BAK1	3.80900688913185
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	28/1202	115/9376	1.89921145916227	JUND/NR4A2/AKAP13/PDE4B/WNK1/GNAI2/PRKCB/PDE4D/ADCY3/MEF2A/CREB1/PRKACB/ITPR2/VDR/CDKN1A/STK39/GNA13/SGK1/ATF2/RUNX2/MEF2D/ITPR1/ARRB2/MAPK1/OXSR1/BCL2/FOS/BGLAP	3.72050905739136
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/1202	93/9376	2.0129891041812	FYN/ROCK1/TGFBR2/RAP1A/IQGAP1/RAP1B/PTPN1/EP300/LEF1/CCM2/RAC2/CREBBP/PTPN6/CSNK2B/WASF2/WAS/PTPRJ/KRIT1/SMAD4/TCF7/MAPK1/SMURF2/ACTN4/HEG1	3.76463285791582
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	33/1202	144/9376	1.78757626178591	NFKBIA/C1QB/C1QA/NFKB1/MAP2K3/CXCL2/LPIN2/PRKAG2/C1QC/CXCL3/LEF1/CASP8/IL1B/FASLG/CASP3/LY96/ACADM/MAP2K7/TNF/TRA2B/FAS/RIPK1/C5AR1/SIRT1/TAB2/CD14/TRAF3/TBK1/TCF7/LPIN1/IRAK1/CPT1A/IRF3	3.6521324640143
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	25/1202	99/9376	1.96978100472277	JUN/DGKZ/PIK3R1/PRKCB/GPCPD1/GRB2/RAC2/EIF4EBP1/KRAS/WASF2/DGKH/WAS/HIF1A/DGKD/RALGDS/DGKE/SOS2/DGKA/PIK3CA/PIK3CD/MAPK1/TSC2/RPS6KB1/FOS/SOS1	3.71970113812573
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	43/1202	204/9376	1.64418779158918	FN1/TIMP3/CD44/DDX5/PPP1R12A/FLNA/TGFB1/EZR/MSN/ROCK1/ITGB1/PIK3R1/PRKCB/STAT3/IQGAP1/PLAUR/MMP9/LUM/IGF2/GRB2/FASLG/PRKACB/PTPN6/KRAS/ITPR2/CASP3/HCLS1/CDKN1A/HIF1A/TNF/FAS/PLAU/SOS2/PTPN11/ITPR1/VAV1/PIK3CA/PIK3CD/MAPK1/RPS6KB1/EIF4B/SOS1/DCN	3.5671067473626
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	32/1202	139/9376	1.79576006416165	CTSD/HSP90AA1/JUN/HSPA1A/GNAI2/PIK3R1/HSP90AB1/FKBP5/HSPA1B/MMP9/HSP90B1/ADCY3/GRB2/NCOA3/CREB1/PRKACB/HSPA8/KRAS/ITPR2/POMC/ATF2/SOS2/ITPR1/PIK3CA/PIK3CD/CALM2/NCOA1/RARA/MAPK1/BCL2/FOS/SOS1	3.62447095303425
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/1202	78/9376	2.10008959426597	IRF1/ITGB2/C1QB/C1QA/JUN/NFKB1/GNAI2/ITGB1/CASP1/C1QC/IL1B/CASP3/LY96/TNF/CD14/IRF8/CALM2/MAPK1/FOS/IRAK1/IRF3	3.74111572430703
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	29/1202	122/9376	1.85417746378986	CSH1/JUNB/STAT1/MAP2K3/SOCS1/GNAI2/CSH2/PIK3R1/PRKCB/STAT3/STAT5A/EP300/ADCY3/GRB2/CREBBP/STAT5B/SOCS3/CREB1/PRKACB/KRAS/ITPR2/ATF2/SOS2/ITPR1/PIK3CA/PIK3CD/MAPK1/FOS/SOS1	3.64152949668127
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	20/1202	75/9376	2.08008874098724	BIRC3/PMAIP1/PIK3R1/BIRC2/ATM/CASP8/FASLG/CASP3/TOP2B/CDKN1A/FAS/REV3L/CYCS/GSTT1/XIAP/PIK3CA/PIK3CD/MAPK1/BCL2/BAK1	3.60118807875435
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	29/1202	125/9376	1.8096772046589	CTSD/NFKB1/FYN/GNAI2/ROCK1/PIK3R1/PRKCB/PPP2R5C/S1PR5/RAC2/ASAH1/KRAS/ORMDL3/ORMDL1/PPP2R2B/GNA13/TNF/CERS2/S1PR4/SGMS1/PPP2R2A/PIK3CA/PIK3CD/DEGS1/PPP2R3C/PPP2R5A/MAPK1/BCL2/S1PR1	3.49456508820378
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	19/1202	70/9376	2.11723318279059	ETS1/JUN/TGFB1/PAK2/PIK3R1/RAP1A/RAP1B/EP300/GRB2/CREBBP/KRAS/CDKN1A/HIF1A/SOS2/PTPN11/PIK3CA/PIK3CD/MAPK1/SOS1	3.59775741875798
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	28/1202	120/9376	1.82007764836384	NFKBIA/JUN/NFKB1/ARHGDIB/MATK/PIK3R1/RAP1A/RAP1B/RPS6KA3/GRB2/MAPKAPK2/FASLG/KRAS/MAP2K7/CAMK4/KIDINS220/NFKBIB/SOS2/PTPN11/PIK3CA/PIK3CD/NFKBIE/CALM2/MAPK1/BCL2/RPS6KA1/SOS1/IRAK1	3.46700510022367
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	15/1202	50/9376	2.34009983361065	CXCR4/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGA4/TGFB1/HLA-DMA/ICOS/HLA-DQB1/HLA-DQA2/HLA-DQA1/CD28/TNFSF13B/HLA-DMB	3.64330059921071
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	19/1202	71/9376	2.08741299711748	IRF1/STAT1/NFKB1/SOCS1/PIK3R1/STAT3/CCND2/STAT5A/GRB2/STAT5B/SOCS3/KRAS/SOCS4/SOS2/PIK3CA/PIK3CD/MAPK1/FOS/SOS1	3.5268424586469
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	23/1202	93/9376	1.92911455817365	FN1/NFKBIA/BIRC3/GADD45B/NFKB1/ITGB1/CDKN1B/PIK3R1/BIRC2/TRAF5/TRAF1/CASP3/CDKN1A/MAX/RB1/CYCS/TRAF3/XIAP/PIK3CA/PIK3CD/BCL2/DDB2/BAK1	3.45292479458179
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	25/1202	105/9376	1.85722209016718	JUN/GABARAPL1/OPTN/TAX1BP1/USP15/MAP1LC3B/SQSTM1/KRAS/CSNK2B/USP8/HIF1A/HUWE1/TBC1D15/GABARAPL2/TFEB/RAB5A/CALCOCO2/TBK1/SMURF2/BECN1/GABARAP/MON1B/UBB/RHOT2/EIF2AK3	3.38723453339311
Human Diseases	Immune disease	hsa05310	Asthma	11/1202	32/9376	2.68136439267887	HLA-DRA/HLA-DRB1/HLA-DPA1/PRG2/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DQA2/HLA-DQA1/HLA-DMB/TNF	3.65334743240442
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	17/1202	62/9376	2.13880092319253	RBPJ/SPEN/LFNG/ATXN1/EP300/TLE4/CIR1/CREBBP/DTX3L/ITCH/TLE3/NOTCH1/SNW1/CTBP1/MFNG/MAML1/MAML2	3.44981728492304
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	25/1202	106/9376	1.8397011270524	NFKBIA/HSP90AA1/NFKB1/CDKN1B/PIK3R1/HSP90AB1/MMP9/EP300/LEF1/HSP90B1/GRB2/CREBBP/CREB1/KRAS/ZEB1/CDKN1A/RB1/PLAU/SOS2/PIK3CA/PIK3CD/TCF7/MAPK1/BCL2/SOS1	3.33394443190871
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	18/1202	69/9376	2.034869420531	FYN/ALOX5AP/LAT/MAP2K3/PIK3R1/LCP2/GRB2/RAC2/KRAS/MAP2K7/TNF/LYN/SOS2/VAV1/PIK3CA/PIK3CD/MAPK1/SOS1	3.30845931119371
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	24/1202	103/9376	1.8175532688238	PABPC1/SRRM1/PNN/RNMT/FUS/PPP2R5C/ACIN1/UPF2/GSPT1/NXT1/PPP2R2B/SMG1/PABPN1/DDX39B/WDR82/SMG6/FIP1L1/PAPOLG/PPP2R2A/CASC3/HBS1L/PPP2R3C/PPP2R5A/DDX19B	3.19922730009347
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	30/1202	142/9376	1.64795762930327	BIRC3/UBE2L6/SOCS1/BIRC2/UBE2B/UBE3A/BIRC6/SOCS3/FBXW11/HUWE1/ITCH/UBE2Q1/UBE4A/CUL3/UBE2O/CBLB/CUL5/FBXW7/UBE2E3/WWP1/XIAP/PIAS1/HERC2/UBE2D3/PML/SMURF2/TRIP12/DDB2/UBR5/UBB	2.98343376269905
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	44/1202	232/9376	1.47937345802972	FN1/CXCR4/RGCC/ITGB2/ITGA4/PPP1R12A/EZR/MSN/ROCK1/ITGB1/PAK2/PIK3R1/IQGAP2/GIT1/TMSB4X/ITGAL/SPATA13/IQGAP1/PIP4K2A/ARPC2/MYH9/RAC2/NCKAP1L/KRAS/WASF2/DIAPH1/F2R/GNA13/LIMK1/FGD3/ARHGEF6/ARHGAP35/SOS2/VAV1/SSH2/PIK3CA/ACTR2/PIK3CD/CYFIP2/MAPK1/APC/LPAR2/ACTN4/SOS1	2.83511332665187
Organismal Systems	Immune system	hsa04611	Platelet activation	27/1202	126/9376	1.67149988115046	APBB1IP/FYN/PPP1R12A/ORAI1/GNAI2/ROCK1/ITGB1/TLN1/PIK3R1/RAP1A/RAP1B/FERMT3/ADCY3/LCP2/PRKACB/ITPR2/RASGRP1/F2R/GNA13/LYN/ARHGAP35/ITPR1/PIK3CA/PIK3CD/STIM1/MAPK1/FCGR2A	2.9099190098147
NA	NA	hsa04517	IgSF CAM signaling	54/1202	299/9376	1.40875575267531	CD2/TUBA4A/CD48/CRTAM/ITGB2/TIGIT/LCK/FYN/CD96/ITGA4/MBP/EZR/MSN/ITGB1/SH2D1A/PAK2/ICAM3/SPTAN1/PIK3R1/CD84/GIT1/PRKCB/ARF6/ITGAL/RAP1A/IQGAP1/ARPC2/RAP1B/ICAM2/CSK/LCP2/SLAMF7/GRB2/MYH9/SRGAP3/CD28/PTPN6/TUBA1A/PRKCQ/SLAMF6/SLAMF1/ICAM1/LYN/NCK2/PTPN11/LY9/VAV1/NCK1/PIK3CA/ACTR2/PIK3CD/MAPK1/TUBB2A/ACTN4	2.75453858078836
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/1202	59/9376	1.98313545221241	GADD45B/PIK3R1/LEF1/GRB2/KRAS/CDKN1A/SOS2/PIK3CA/PIK3CD/TCF7/MAPK1/DDB2/APC/BAK1/SOS1	2.90483768830874
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	62/1202	362/9376	1.33596859745728	SPP1/FN1/CSH1/IL2RG/JAK1/HSP90AA1/NFKB1/DDIT4/ITGA4/GNG2/MCL1/CSH2/ITGB1/CDKN1B/PIK3R1/BCL2L11/HSP90AB1/PPP2R5C/CCND2/IL7R/IL4R/IL2RA/NR4A1/PKN1/HSP90B1/JAK3/AREG/FLT3LG/IGF2/GRB2/PKN2/EIF4EBP1/FASLG/CREB1/YWHAZ/KRAS/PPP2R2B/F2R/CDKN1A/PIK3AP1/SGK1/CDC37/RBL2/ATF2/OSM/SOS2/IFNAR2/PPP2R2A/PIK3CA/EREG/PIK3CD/YWHAQ/PPP2R3C/PPP2R5A/MAPK1/TSC2/RPS6KB1/BCL2/EIF4B/LPAR2/SOS1/IFNAR1	2.49985460418574
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	31/1202	158/9376	1.53044503885928	GADD45B/ATRX/TGFB1/NIPBL/CDKN1B/PPP2R5C/CCND2/STAG2/ATM/EP300/SMC1A/CREBBP/YWHAZ/CCNH/CDKN1A/RB1/RBL2/SMC3/CDC25B/DBF4/ESCO1/RAD21/SMAD4/YWHAQ/MAD1L1/PPP2R5A/PDS5B/ATR/DDX11/MAU2/PDS5A	2.57852376729578
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	40/1202	217/9376	1.43784936012943	HSP90AA1/JUN/NFKB1/GNAI2/PIK3R1/HSP90AB1/PRKCB/STAT3/STAT5A/RPS6KA3/HSP90B1/ADCY3/GRB2/EIF4EBP1/STAT5B/CREB1/PRKACB/KRAS/VDR/AIP/RB1/ATF2/MIR29A/GSTT1/KPNA3/SOS2/XIAP/KPNA6/PIK3CA/PIK3CD/ARRB2/MAPK1/RPS6KB1/BCL2/BCL6/RPS6KA1/FOS/SOS1/KPNA4/KLF4	2.50236762215007
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	25/1202	122/9376	1.59842884809471	STAT1/NCOR1/PIK3R1/PRKCB/EP300/MED13/NCOA3/CREBBP/PRKACB/KRAS/ATP1B3/TBC1D4/HIF1A/MED13L/MED14/NOTCH1/ATP1A1/PIK3CA/PIK3CD/MED4/NCOA1/HDAC3/MAPK1/TSC2/ATP2A2	2.5512219584126
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	23/1202	110/9376	1.63097867191045	SKIL/NCOR1/TGFB1/IFNG/ROCK1/TGFBR2/SMAD7/EMP3/EP300/TGIF2/CREBBP/FBN1/HAMP/TNF/LEMD3/SMAD4/NBL1/MAPK1/SMURF2/RPS6KB1/TGIF1/DCN/ZFYVE16	2.55261566222779
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	43/1202	238/9376	1.40930382136216	NFKBIA/STAT1/JAK1/C1QB/C1QA/JUN/NFKB1/MX1/PIK3R1/ADAR/RPS29/ISG15/PRKCB/STAT3/CASP1/IRF9/EIF2AK2/C1QC/OAS2/IL1B/OAS1/CXCL10/RPL28/STAT2/IFIH1/MX2/TNF/C5AR1/TAB2/NFKBIB/IFNAR2/TRAF3/PIK3CA/TBK1/PIK3CD/MAPK1/RPL36AL/FOS/IRAK1/IFNAR1/RPS21/FCGR2A/IRF3	2.45261430149893
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	28/1202	142/9376	1.53809378734972	NFE2L2/HSP90AA1/DUSP1/JUN/NFKB1/CYBA/IFNG/KLF2/PIK3R1/HSP90AB1/MMP9/HSP90B1/MEF2A/SQSTM1/RAC2/IL1B/ARHGEF2/NCF1/MAP2K7/ICAM1/TNF/NCF2/GSTT1/PIK3CA/PIK3CD/CALM2/BCL2/FOS	2.47758047760616
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	17/1202	75/9376	1.76807542983916	GADD45B/CD82/SERPINE1/PMAIP1/CCND2/ATM/MDM4/CASP8/CASP3/SESN3/CDKN1A/FAS/CYCS/TSC2/BCL2/DDB2/ATR	2.56088594997544
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	21/1202	99/9376	1.65461604396713	JUN/NCOR1/CDKN1B/PIK3R1/MMP9/ADCY3/GRB2/NCOA3/PRKACB/KRAS/CDKN1A/RB1/NOTCH1/SOS2/PIK3CA/PIK3CD/MAPK1/RPS6KB1/BCL2/FOS/SOS1	2.51085145194813
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	10/1202	37/9376	2.10819804829788	IFNG/PRKCB/IL1B/FASLG/ICAM1/TNF/FAS/APOL1/IL18/HBB	2.58993348515795
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1202	37/9376	2.10819804829788	GADD45B/TPM3/TPR/LEF1/KRAS/CDKN1A/TCF7/MAPK1/DDB2/BAK1	2.58993348515795
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	19/1202	90/9376	1.64673691994823	NFKB1/PIK3R1/PRKAG2/RB1CC1/ADCY3/EIF4EBP1/CREB1/PRKACB/KRAS/SESN3/CAMK4/ATF2/SIRT1/EHMT1/PIK3CA/PIK3CD/EHMT2/TSC2/RPS6KB1	2.36404165366318
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1202	44/9376	1.95008319467554	ARHGDIB/VAMP2/ADCY3/CREB1/PRKACB/DYNC1H1/DYNC1LI2/RAB5A/AQP3/DCTN1/RAB11B	2.42226227146706
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	15/1202	67/9376	1.74634315941093	PRKCB/RAP1A/RAP1B/RPS6KA3/EP300/CREBBP/PRKACB/KRAS/ITPR2/CAMK4/ITPR1/PPP3CC/CALM2/MAPK1/RPS6KA1	2.35095869129189
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/1202	56/9376	1.810791537913	CCND2/CSNK1G2/PRKACB/CSNK1D/CSNK1G3/FBXW11/SPOP/CUL3/KIF3A/ARRB2/SMURF2/BCL2/CSNK1G1	2.33354306479666
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	20/1202	99/9376	1.57582480377821	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGB2/C1QB/C1QA/HLA-DMA/FCGR3A/SELPLG/ITGAL/HLA-DQB1/HLA-DQA2/HLA-DQA1/C1QC/HLA-DMB/ICAM1/C5AR1/FCGR2A/FCGR1A	2.20863903040373
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1202	170/9376	1.42241362435157	GADD45B/NFE2L2/TGFB1/TGFBR2/PIK3R1/PRKCB/SMARCC2/LEF1/IGF2/GRB2/KRAS/CDKN1A/RB1/ARID1A/SMARCD1/PBRM1/GSTT1/SOS2/SMAD4/PIK3CA/PIK3CD/TCF7/MAPK1/RPS6KB1/DDB2/APC/BAK1/SOS1/ARID2/SMARCC1/SMARCE1	2.13131405078265
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/1202	63/9376	1.73340728415604	KMT2E/KMT2A/SETD2/PHYKPL/PRDM2/KMT2B/ASH1L/NSD1/KMT2C/EHMT1/EHMT2/EZH1/SETDB2/HADHA	2.23970720771632
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1202	76/9376	1.64217532183203	GADD45B/PIK3R1/PRKCB/GRB2/KRAS/CDKN1A/RB1/CAMK4/SOS2/PIK3CA/PIK3CD/CALM2/MAPK1/DDB2/BAK1/SOS1	2.15545762471857
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	21/1202	109/9376	1.50281640690592	NFKBIA/NFKB1/PIK3R1/PRKCB/STAT3/PRKAG2/RPS6KA3/PTPN1/OGT/SOCS3/CREB1/TBC1D4/PRKCQ/TNF/PTPN11/PIK3CA/PIK3CD/RPS6KB1/NR1H2/RPS6KA1/CPT1A	2.02476051527976
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	27/1202	149/9376	1.41348312097288	FYN/DGKZ/PIK3R1/ARF6/CYTH1/ADCY3/GRB2/PTK2B/CYTH4/KRAS/DNM2/DGKH/F2R/GNA13/DGKD/RALGDS/DGKE/SOS2/PTPN11/DGKA/PIK3CA/PIK3CD/MAPK1/TSC2/LPAR2/SOS1/CYTH2	1.95092787910506
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	19/1202	98/9376	1.51230941627899	DGKZ/PIK3R1/PRKCB/PIP4K2A/SACM1L/ITPKB/ITPR2/DGKH/DGKD/IP6K1/DGKE/INPP5F/DGKA/ITPR1/PIK3CA/CDIPT/PIK3CD/CALM2/PIK3C3	1.95496392342977
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	19/1202	98/9376	1.51230941627899	NR4A2/ORAI1/PRKCB/NR4A1/ADCY3/CREB1/PRKACB/ATP1B3/ITPR2/ATP2B1/ATP2B4/POMC/PRKD3/CAMK4/ATF2/ATP1A1/ATF1/ITPR1/CALM2	1.95496392342977
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	40/1202	238/9376	1.31098029894154	REL/ETS1/STK4/NFKB1/LAT/GNG2/PAK2/RASSF5/RALGAPA1/PIK3R1/PRKCB/ARF6/RAP1A/RASA2/RAP1B/RASAL3/FLT3LG/IGF2/GRB2/RAC2/ZAP70/FASLG/PRKACB/KRAS/RASGRP1/RALGDS/RASA3/SHOC2/SOS2/PTPN11/RAB5A/PIK3CA/TBK1/PIK3CD/CALM2/EXOC2/MAPK1/SOS1/ETS2/BRAP	1.86344394765271
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/1202	138/9376	1.41310376425764	SOCS1/PIK3R1/PRKAG2/PDE3B/PTPN1/GRB2/EIF4EBP1/SOCS3/FBP1/PRKACB/KRAS/SOCS4/RHOQ/CBLB/PRKAR2A/PRKAR1B/SOS2/PRKAR1A/PIK3CA/PIK3CD/CALM2/MAPK1/TSC2/RPS6KB1/SOS1	1.87469349286213
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1202	38/9376	1.84744723706104	PIK3R1/PRKCB/KRAS/ATP1B3/SGK1/ATP1A1/PIK3CA/PIK3CD/MAPK1	2.00723437984032
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	14/1202	70/9376	1.56006655574043	NFKBIA/TNFRSF1B/NFKB1/STAT3/PRKAG2/SOCS3/PRKCQ/ACSL3/TNF/POMC/NFKBIB/PTPN11/NFKBIE/CPT1A	1.80354794052967
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	34/1202	203/9376	1.30645967722105	SPP1/FN1/BIRC3/JUN/FYN/ITGA4/PPP1R12A/FLNA/ROCK1/ITGB1/PAK2/TLN1/PIK3R1/PRKCB/RAP1A/BIRC2/CCND2/ZYX/RAP1B/PARVG/CAPN2/GRB2/RAC2/DIAPH1/ARHGAP35/SOS2/XIAP/VAV1/PIK3CA/PIK3CD/MAPK1/BCL2/ACTN4/SOS1	1.69272425550755
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1202	34/9376	1.83537241851816	RORA/BHLHE40/PRKAG2/PER1/CREB1/CSNK1D/FBXW11/NR1D2	1.87120002438381
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1202	71/9376	1.53809378734972	NFKBIA/CCL5/JUN/NFKB1/GIT1/CXCL2/CXCL3/CSK/CASP3/ATP6V0B/TCIRG1/LYN/PTPN11/ADAM10	1.74521733783736
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	23/1202	130/9376	1.38005887623192	NFKBIA/JUN/NFKB1/GNG2/TGFB1/GNAI2/TGFBR2/PIK3R1/MMP9/ADCY3/GRB2/CREB1/PRKACB/KRAS/MAP2K7/ATF2/SOS2/PIK3CA/PIK3CD/ARRB2/MAPK1/FOS/SOS1	1.67327054771817
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/1202	78/9376	1.50006399590426	BTG1/BTG2/CNOT6L/PABPC1/DDX6/XRN1/CNOT2/CNOT4/DHX36/TOB1/XRN2/CNOT1/HSPA9/EXOSC9/TOB2	1.70058628677924
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	17/1202	93/9376	1.42586728212835	JUN/MAP2K3/PRKCB/ADCY3/MAP3K2/GRB2/PTK2B/PRKACB/KRAS/ITPR2/MAP2K7/SOS2/ITPR1/CALM2/MAPK1/SOS1/MAP3K4	1.58267641457762
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1202	80/9376	1.46256239600666	JAK1/PIK3R1/BCL2L11/PRKCB/STAT3/GRB2/EIF4EBP1/KRAS/SOS2/PIK3CA/PIK3CD/MAPK1/RPS6KB1/BCL2/SOS1	1.59326426385598
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	12/1202	62/9376	1.5097418281359	HSPA1A/PIK3R1/HSPA1B/PRKAG2/ADCY3/PRKACB/HSPA8/KRAS/SIRT1/PIK3CA/PIK3CD/RPS6KB1	1.54418224795749
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	19/1202	108/9376	1.37228076662353	TPR/SRRM1/PNN/ACIN1/UPF2/THOC2/RANBP2/NXT1/POM121C/DDX39B/EEF1A1/KPNA3/NUP214/KPNA6/CASC3/NUP210/AHCTF1/DDX19B/KPNA4	1.49214153709947
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1202	50/9376	1.56006655574043	ITGB2/TGFB1/IFNG/CD81/ITGAL/IL1B/ICAM1/TNF/IL18/HBB	1.52264090103591
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1202	89/9376	1.40230701639589	TUBA4A/GNAI2/PRKCB/ADCY3/MAP3K2/GRB2/PRKACB/KRAS/CSNK1D/ITPR2/TUBA1A/SOS2/ITPR1/MAPK1/TUBB2A/SOS1	1.46229650770178
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1202	44/9376	1.59552261382544	TAF7/GTF2B/TAF3/GTF2I/CCNH/TAF10/GTF2F1/TAF15/GTF2E2	1.5183006786763
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/1202	103/9376	1.36316495161785	FN1/ITGB2/NFKB1/TGFB1/IFNG/PIK3R1/PRKCB/CXCL2/CXCL3/IL1B/PRKACB/CASP3/TNF/CD14/RAB5A/PIK3CA/PIK3CD/ACTN4	1.42112724877791
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/1202	110/9376	1.34733020723037	NFKB1/SERPINE1/IFNG/CDKN1B/PIK3R1/PRKCB/STAT3/EP300/CREBBP/EIF4EBP1/PFKFB3/CDKN1A/HIF1A/PIK3CA/PIK3CD/MAPK1/RPS6KB1/BCL2/IFNGR1	1.40511964415003
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1202	32/9376	1.7063227953411	GABARAPL1/GABARAPL2/ATG2A/PIK3C3/ATG12/BECN1/GABARAP	1.53473130633911
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	23/1202	140/9376	1.28148324221536	SPP1/SERPINE1/GNG2/KLF2/GNAI2/PRKAG2/PDE3B/MAP1LC3B/ADCY3/MEF2A/PRKACB/KRAS/ITPR2/GNA13/CAMK4/MEF2D/ITPR1/SMAD4/CALM2/PIK3C3/MAPK1/RPS6KB1/BECN1	1.28675290024597
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1202	53/9376	1.47176090164192	PRKCB/PRKACB/ATP1B3/DNM2/VDR/ATP2B1/ATP2B4/ATP1A1/CLTB/AP2B1	1.32069517998638
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1202	60/9376	1.43006100942873	SH2D2A/PIK3R1/PRKCB/NFATC2/MAPKAPK2/RAC2/KRAS/PIK3CA/PPP3CC/PIK3CD/MAPK1	1.28147904985713
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/1202	158/9376	1.23422987004781	DDIT4/PIK3R1/PRKCB/LPIN2/SLC7A5/RPS6KA3/PRR5L/GRB2/EIF4EBP1/KRAS/RICTOR/SGK1/TNF/SLC3A2/SOS2/PIK3CA/PIK3CD/MAPK1/TSC2/RPS6KB1/EIF4B/CLIP1/LPIN1/RPS6KA1/SOS1	1.13860483685116
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/1202	75/9376	1.35205768164171	PRKCB/HSP90B1/ADCY3/HSPA5/CREB1/PRKACB/ATP1B3/ITPR2/ATF2/ATP1A1/ITPR1/TTF2/TTF1	1.1738164449369
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	41/1202	275/9376	1.16295870518832	CCL5/TUBA4A/C1QB/C1QA/HSPA1A/CYBA/FYN/MT-ND5/PIK3R1/MT-ND4L/HSPA1B/C1QC/PRNP/MT-ND2/RAC2/IL1B/MT-ND6/HSPA5/DDIT3/CREB1/PRKACB/HSPA8/ITPR2/CSNK2B/CASP3/TUBA1A/NCF1/MT-ATP8/TNF/NCF2/NOTCH1/ATF2/CYCS/KIF5B/ITPR1/PIK3CA/PPP3CC/PIK3CD/MAPK1/TUBB2A/EIF2AK3	1.05176789597927
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	34/1202	226/9376	1.17350139148617	NFKBIA/JUN/PDE4B/NFKB1/PPP1R12A/ORAI1/GNAI2/ROCK1/PIK3R1/RAP1A/PDE3B/RAP1B/PDE4D/EP300/ADCY3/RAC2/CREBBP/CREB1/PRKACB/ATP1B3/ATP2B1/F2R/ATP2B4/POMC/CAMK4/ATP1A1/VAV1/PIK3CA/PIK3CD/CALM2/NFATC1/MAPK1/FOS/ATP2A2	1.01243509260235
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	23/1202	148/9376	1.21221387777128	GADD45B/JUN/PIK3R1/NFKB2/LEF1/GRB2/NCOA3/KRAS/CDKN1A/RB1/NOTCH1/SOS2/PIK3CA/PIK3CD/TCF7/NCOA1/MAPK1/RPS6KB1/DDB2/APC/BAK1/FOS/SOS1	0.997864106959722
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1202	12/9376	1.95008319467554	SLAMF1/CD46/NPC1	1.26282192102493
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/1202	78/9376	1.30005546311703	FN1/ITGB1/PIK3R1/RHOG/ARPC2/DNM2/WASF2/HCLS1/PIK3CA/ACTR2/PIK3CD/CLTB/ELMO2	1.02040980760331
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/1202	65/9376	1.32005631639575	DGKZ/LPIN2/DGKH/PNPLA2/GK/DGKD/LPL/AGK/DGKE/DGKA/LPIN1	0.992899913533375
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1202	150/9376	1.19605102606766	GADD45B/TGFB1/CDKN1B/TGFBR2/PIK3R1/LEF1/GRB2/KRAS/CDKN1A/RB1/ABCB1/SOS2/SMAD4/PIK3CA/PIK3CD/TCF7/MAPK1/RPS6KB1/BCL2/DDB2/APC/BAK1/SOS1	0.92817224864161
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	19/1202	122/9376	1.21480592455198	PIK3R1/PPP2R5C/PRKAG2/EIF4EBP1/CREB1/FBP1/PFKFB3/PPP2R2B/TBC1D1/SIRT1/PPP2R2A/PIK3CA/PIK3CD/PPP2R3C/PPP2R5A/TSC2/RPS6KB1/RAB11B/CPT1A	0.915760651009581
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	25/1202	166/9376	1.17474891245515	RGS2/PPP1R12A/GNAI2/ROCK1/NFATC3/PDE3B/NFATC2/ADCY3/MEF2A/GTF2I/CREB1/ATP1B3/ITPR2/ATP2B1/GNA13/ATP2B4/ATF2/ATP1A1/MEF2D/ITPR1/PPP3CC/CALM2/NFATC1/MAPK1/ATP2A2	0.871082453866761
NA	NA	hsa04518	Integrin signaling	23/1202	154/9376	1.16498476565032	SPP1/FN1/ITGB2/ITGA4/FLNA/TGFB1/ITGB1/ICAM3/TLN1/PIK3R1/ITGAL/CCND2/FERMT3/PARVG/ICAM2/RAC2/FBN1/ICAM1/ARHGEF6/NCK2/PIK3CA/PIK3CD/ACTN4	0.791611693796168
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1202	20/9376	1.56006655574043	LBR/LIPA/SC5D/HSD17B7	0.961457488221694
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1202	47/9376	1.32771621765143	SOCS1/PIK3R1/SOCS3/SOCS4/TNF/PIK3CA/PIK3CD/MAPK1	0.863674051211816
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1202	14/9376	1.67149988115046	B3GNT2/FUT8/B4GALT1	0.964153528399129
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1202	69/9376	1.24353131254672	CTSB/ORAI1/PTGER4/GNAI2/PDE3B/CREB1/PRKACB/ITPR2/ITPR1/PPP3CC/CALM2	0.778565317109292
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/1202	178/9376	1.13937445082166	JUN/PRKCB/CCDC88C/TBL1XR1/CCND2/NOTUM/NFATC3/NFATC2/EP300/LEF1/TLE4/RAC2/CREBBP/PRKACB/CSNK2B/FBXW11/CHD8/TLE3/SIRT1/SMAD4/PPP3CC/DAAM1/CTBP1/TCF7/NFATC1/APC	0.719891462352843
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1202	41/9376	1.33176413294915	POLD4/ATM/RAD50/UIMC1/BARD1/NBN/TOPBP1	0.816365710974213
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/1202	55/9376	1.27641809106035	PSAP/HEXB/ASAH1/HEXA/CERS2/CERK/SGMS1/DEGS1/NEU1	0.788382743236288
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1202	48/9376	1.30005546311703	CD81/TGOLN2/LAMP1/CD9/CHMP1B/VPS4B/CHMP4A/PDCD6IP	0.799187060540895
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1202	49/9376	1.27352371897178	LFNG/OGT/GALNT7/ST6GAL1/GALNT2/GALNT3/B4GALT1/MFNG	0.736109800117401
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1202	42/9376	1.30005546311703	FTL/SAT1/PRNP/MAP1LC3B/ACSL3/PCBP1/SLC3A2	0.747330729966987
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	45/1202	323/9376	1.08673366885943	TIMP3/VIM/CD44/ZEB2/NFKB1/DDIT4/FOXP1/EZR/MCL1/SOCS1/ROCK1/CDKN1B/GLS/PIK3R1/BCL2L11/PRKCB/STAT3/CCND2/MMP9/ATM/EP300/GRB2/CREBBP/MDM4/KRAS/CASP3/ZEB1/CDKN1A/ABCB1/PLAU/CDC25B/NOTCH1/SIRT1/MIR29A/SOS2/DNMT3A/PIK3CA/PIK3CD/MAPK1/BCL2/APC/MARCKS/BAK1/SOS1/PIM1	0.608293637418321
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1202	15/9376	1.56006655574043	HEXB/ST3GAL5/HEXA	0.832424208586863
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	17/1202	115/9376	1.15309267163423	FYN/GNG2/GNAI2/PIK3R1/PRKCB/ADCY3/CREB1/PRKACB/KRAS/ITPR2/CAMK4/ITPR1/PIK3CA/PIK3CD/MAPK1/BCL2/FOS	0.633424614012422
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	30/1202	212/9376	1.10382067623144	ITGB2/APBB1IP/LAT/MAP2K3/GNAI2/ITGB1/TLN1/RASSF5/PIK3R1/PRKCB/ITGAL/RAP1A/RAP1B/ADCY3/LCP2/RAC2/KRAS/SKAP1/SIPA1/F2R/RALGDS/PRKD3/KRIT1/VAV1/PIK3CA/PIK3CD/SIPA1L1/CALM2/MAPK1/LPAR2	0.586313371521647
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1202	65/9376	1.20005119672341	SPP1/PIK3R1/PRKCB/KRAS/ITPR2/ITPR1/PIK3CA/PIK3CD/ARRB2/MAPK1	0.620612079042096
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	22/1202	154/9376	1.11433325410031	JUN/RGS2/PPP1R12A/GNAI2/ROCK1/CD38/PRKCB/PRKAG2/NFATC3/NFATC2/ADCY3/PRKACB/KRAS/ITPR2/CDKN1A/CAMK4/ITPR1/PPP3CC/CALM2/NFATC1/MAPK1/FOS	0.548581201293455
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/1202	44/9376	1.24096203297534	HEXB/MGAT4A/HEXA/FUT8/ALG13/B4GALT1/RPN1	0.614339085885533
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1202	44/9376	1.24096203297534	POLD4/RFC1/MBD4/MPG/TDG/PARP4/PARP1	0.614339085885533
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	16/1202	110/9376	1.13459385872031	HSP90AA1/GNAI2/PIK3R1/HSP90AB1/PDE3B/RPS6KA3/ADCY3/PRKACB/KRAS/CDC25B/STK10/PIK3CA/PIK3CD/MAD1L1/MAPK1/RPS6KA1	0.544497630591717
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1202	88/9376	1.15232188776282	SERPINE2/ITGB2/C1QB/C1QA/SERPINE1/PLAUR/C1QC/F2R/CD46/PLAU/C5AR1/A2M/SERPINA1	0.550507324263721
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	22/1202	155/9376	1.10714400729966	KMT2A/ORAI1/GNAI2/CDKN1B/RAP1A/RAP1B/NR4A1/LEF1/ADCY3/CREB1/PRKACB/ITPR2/AIP/CDKN1A/RB1/USP8/POMC/ATF2/ITPR1/TCF7/MAPK1/APC	0.515780927544766
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1202	52/9376	1.20005119672341	APOE/APOC1/TSPO/LIPA/STARD3/LPL/CYP27A1/NPC1	0.554705214461524
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	22/1202	157/9376	1.09304026198374	BIRC3/ITGB2/SERPINE1/TGFB1/TGFBR2/SMAD7/BIRC2/CCND2/LEF1/AREG/YWHAZ/CSNK1D/PPP2R2B/FBXW11/MOB1A/DLG3/PPP2R2A/SMAD4/TP53BP2/YWHAQ/TCF7/APC	0.450816080340299
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	22/1202	157/9376	1.09304026198374	JUN/NFKB1/TGFB1/PIK3R1/BCL2L11/PRKAG2/CASP8/IL1B/SOCS3/FASLG/DDIT3/CASP3/ITCH/TNF/FAS/CYCS/MAP3K11/XBP1/PIK3CA/PIK3CD/FOS/EIF2AK3	0.450816080340299
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/1202	143/9376	1.09095563338492	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/C1QB/C1QA/IFNG/HLA-DMA/FCGR3A/HLA-DQB1/HLA-DQA2/HLA-DQA1/C1QC/CD28/HLA-DMB/TNF/TRIM21/ACTN4/FCGR2A/FCGR1A	0.420287775981199
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1202	61/9376	1.15086877062819	FTL/MT1X/ATP1B3/VDR/ATP2B1/SLC30A1/ATP2B4/ATP1A1/TRPM7	0.453308011602105
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/1202	144/9376	1.08337955259752	JAK1/SKIL/PIK3R1/STAT3/KAT6A/JAK3/RIF1/GRB2/KRAS/PCGF5/REST/SMAD4/PIK3CA/JARID2/SMARCAD1/PIK3CD/TCF7/MAPK1/APC/KLF4	0.386645948655035
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	20/1202	144/9376	1.08337955259752	RBPJ/RORA/PIK3R1/PRKCB/ATXN1/ATXN2L/RB1CC1/GTF2B/ITPR2/NRBF2/CYCS/ITPR1/XBP1/PIK3CA/ATG2A/PIK3CD/NOP56/PIK3C3/BECN1/ATP2A2	0.386645948655035
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/1202	99/9376	1.10307736264475	MAP2K3/PTGER4/PIK3R1/PRKCB/ADCY3/PRKCH/IL1B/PRKACB/ITPR2/PRKCQ/ITPR1/PIK3CA/PIK3CD/CALM2	0.39536450113733
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1202	69/9376	1.13048301140611	JUN/PRKCB/CREB1/PRKACB/CAMK4/ATF2/SIRT1/PPP3CC/CALM2/FOS	0.417151889382947
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1202	107/9376	1.09350459514516	PRKAG2/SIK1/PDE3B/EP300/CREBBP/CREB1/FBP1/PRKACB/ITPR2/ATF2/SIRT1/ITPR1/PPP3CC/CALM2/CPT1A	0.373017285436318
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	19/1202	138/9376	1.07395886083581	PPP2R5C/SLK/RPS6KA3/SMC1A/ADCY3/PRKACB/YWHAZ/ITPR2/FBXW11/SMC3/ITPR1/PPP3CC/YWHAQ/CALM2/MAD1L1/PPP2R5A/MAPK1/RPS6KA1/REC8	0.335630432701428
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1202	18/9376	1.30005546311703	HEXB/HEXA/NEU1	0.488615034424688
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1202	93/9376	1.09036909809815	LYZ/CD38/PRKCB/VAMP2/ADCY3/PRKACB/ATP1B3/ITPR2/ATP2B1/ATP2B4/ATP1A1/ITPR1/CALM2	0.335844161241506
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1202	33/9376	1.18186860283366	VAMP5/VAMP2/STX11/VTI1A/STX16	0.401321180712511
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	23/1202	170/9376	1.05533914064794	TUBA4A/JUN/EZR/MSN/ROCK1/ITGB1/RAP1A/PRKAG2/ARPC2/MYH9/ARHGEF2/PRKACB/RAB8B/PPP2R2B/HCLS1/WAS/TUBA1A/WHAMM/MAP2K7/DLG3/PPP2R2A/ACTR2/ACTN4	0.27921705461618
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1202	71/9376	1.09863841953552	GLS/PIK3R1/SLC7A5/KRAS/HIF1A/G6PD/SCO2/PIK3CA/PIK3CD/MAPK1	0.319917241189733
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1202	41/9376	1.14151211395641	TYMP/MMP9/KRAS/CDKN1A/RB1/MAPK1	0.348216175433282
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/1202	133/9376	1.05568413546345	GNG2/GNAI2/PRKCB/PPP2R5C/CREB1/PRKACB/ITPR2/PPP2R2B/ATF2/KIF5B/ITPR1/PPP2R2A/PPP3CC/CALM2/ARRB2/PPP2R3C/PPP2R5A/FOS	0.24801124964905
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/1202	49/9376	1.11433325410031	JUN/NFKB1/GNAI2/CREB1/PRKACB/RGS9/ATF2	0.307694810303574
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1202	34/9376	1.14710776157385	POLR2A/POLR3GL/POLR2B/CRCP/POLR3E	0.329515364575146
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1202	19/9376	1.23163149137403	IDS/HEXB/HEXA	0.387549021319439
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1202	65/9376	1.08004607705107	ORAI1/NR4A1/ADCY3/CREB1/PRKACB/ITPR2/POMC/ATF2/ITPR1	0.248324244550817
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1202	73/9376	1.06853873680852	GADD45B/PIK3R1/KRAS/CDKN1A/RB1/PIK3CA/PIK3CD/MAPK1/DDB2/BAK1	0.225427331920024
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1202	89/9376	1.05173026229692	GNG2/GABARAPL1/GNAI2/GLS/PRKCB/SLC38A2/GLUL/SLC38A1/ADCY3/PRKACB/GABARAPL2/GABARAP	0.188027995576506
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1202	59/9376	1.05767224117995	GNAI2/PIK3R1/PDE3B/ADCY3/PRKACB/PNPLA2/PIK3CA/PIK3CD	0.170402256750849
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/1202	184/9376	1.0174347102655	CXCR4/FYN/GNAI2/ROCK1/ITGB1/PAK2/PIK3R1/SEMA4D/NFATC3/NFATC2/RAC2/SRGAP3/KRAS/LIMK1/NCK2/PTPN11/SSH2/NCK1/PIK3CA/PPP3CC/PIK3CD/ABLIM1/MAPK1/EPHB6	0.0915881303501449
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1202	60/9376	1.04004437049362	GNAI2/PRKCB/KRAS/ITPR2/GNA13/LYN/ITPR1/MAPK1	0.119322655919119
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/1202	154/9376	1.01303023100028	CREM/TPM3/GNAI2/PPP2R5C/ADCY3/CREB1/PRKACB/ATP1B3/ATP2B1/PPP2R2B/ATP2B4/ATF2/ATP1A1/PPP2R2A/CALM2/PPP2R3C/PPP2R5A/MAPK1/BCL2/ATP2A2	0.0625202162880271
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1202	21/9376	1.11433325410031	CHST11/CSGALNACT2/CHST12	0.201131860610874
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1202	76/9376	1.02635957614502	EZR/GNAI2/PRKCB/ADCY3/PRKACB/ATP1B3/ITPR2/ATP1A1/ITPR1/CALM2	0.0884757595854753
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	47/1202	368/9376	0.996238153801635	TNFRSF1B/TUBA4A/TPR/MT-ND5/MAP2K3/MT-ND4L/FUS/CASP1/OPTN/SRSF7/ATXN2L/RB1CC1/SETX/MATR3/MAP1LC3B/MT-ND2/SQSTM1/RANBP2/MT-ND6/HSPA5/DDIT3/NXT1/POM121C/CASP3/TUBA1A/TANK/MT-ATP8/TNF/NRBF2/CYCS/KIF5B/NUP214/XBP1/RAB5A/ATG2A/PPP3CC/NUP210/TBK1/SPG11/DCTN1/PIK3C3/DAXX/BCL2/TUBB2A/RAB39B/BECN1/EIF2AK3	-0.0282313282423947
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1202	101/9376	1.00400322894186	GNAI2/PRKCB/EP300/LEF1/ADCY3/CREBBP/CREB1/PRKACB/KRAS/POMC/TCF7/CALM2/MAPK1	0.015510818319033
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1202	38/9376	1.02635957614502	NAMPT/CD38/SIRT7/SIRT1/NNT	0.0624343854843378
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/1202	46/9376	1.0174347102655	PSMB9/IFNG/PSME1/PSMB8/PSME2/PSMB10	0.0454541335751951
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/1202	31/9376	1.0064945520906	SEC62/HSPA5/SPCS2/SRP54	0.0138886794292873
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1202	23/9376	1.0174347102655	CTSA/LNPEP/ATP6AP2	0.0321013828183216
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1202	23/9376	1.0174347102655	GLS/ATP1B3/ATP1A1	0.0321013828183216
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	13/1202	104/9376	0.97504159733777	DGKZ/LPIN2/GPCPD1/DGKH/DGKD/DGKE/SGMS1/LPGAT1/DGKA/CDIPT/LPCAT4/PLD3/LPIN1	-0.0981448014062464
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1202	48/9376	0.97504159733777	PIK3R1/PRKCB/ATP1B3/ATP1A1/PIK3CA/PIK3CD	-0.0664758183444367
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	28/1202	227/9376	0.962155585038152	NFKBIA/NFE2L2/JUN/NFKB1/CYBA/MT-ND5/PIK3R1/MT-ND4L/PTPN1/MT-ND2/GRB2/MT-ND6/KRAS/NCF1/HIF1A/MT-ATP8/PTPRJ/MAP2K7/NCF2/PRKD3/GSTT1/SOS2/PTPN11/PIK3CA/PIK3CD/MAPK1/FOS/SOS1	-0.2213341698294
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	29/1202	235/9376	0.962594257797288	MT-ND5/MAP2K3/MT-ND4L/PRKAG2/SMARCC2/RPS6KA3/ADCY3/MT-ND2/GRB2/MT-ND6/CREB1/PRKACB/KRAS/PNPLA2/MT-ATP8/ACSL3/ARID1A/SMARCD1/ATF2/KDM3A/SOS2/SLC25A20/TSC2/RPS6KB1/RPS6KA1/SOS1/SMARCC1/SMARCE1/CPT1A	-0.222687535240516
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1202	16/9376	0.97504159733777	HEXB/HEXA	-0.0383141688959584
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/1202	91/9376	0.942897368854108	PDE4B/GNG2/GNAI2/PRKCB/PDE3B/PDE4D/ADCY3/PDE7A/PRKACB/GRK6/ARRB2	-0.209897089894444
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1202	17/9376	0.917686209259078	GLUL/CA5B	-0.130257546849501
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1202	17/9376	0.917686209259078	LAMP1/MYH9	-0.130257546849501
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/1202	102/9376	0.917686209259078	CD38/PRKCB/RAP1A/RAP1B/ADCY3/ATP1B3/ITPR2/ATP2B1/ATP2B4/ATP1A1/ITPR1/ATP2A2	-0.320523368210129
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/1202	78/9376	0.900038397542557	PIP4K2A/SACM1L/ITPKB/IP6K1/INPP5F/PIK3CA/CDIPT/PIK3CD/PIK3C3	-0.339943150748551
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/1202	194/9376	0.924781721186339	TUBA4A/TPM3/KIF2A/KIF21A/MYH9/TUBA1A/DYNC1H1/MYO5A/KIF13B/MYO9B/CAPZA1/MYO1F/KIF20B/KIF3A/KIF5B/DYNC1LI2/KIF3B/KIFAP3/HOOK3/MYO1G/DCTN1/KIF21B/TUBB2A	-0.405953385423272
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1202	36/9376	0.866703642078018	GCNT1/GALNT7/GALNT2/GALNT3	-0.307267516966503
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	58/1202	480/9376	0.942540210759845	TNFRSF1B/TUBA4A/UBE2L6/NFKB1/MT-ND5/MAP2K3/MT-ND4L/PRKCB/FUS/ATXN1/OPTN/ATXN2L/RB1CC1/CAPN2/PRNP/MAP1LC3B/MT-ND2/SQSTM1/CASP8/IL1B/MT-ND6/HSPA5/FASLG/DDIT3/KRAS/ITPR2/CSNK2B/CASP3/TUBA1A/TANK/MT-ATP8/MAP2K7/TNF/FAS/NRBF2/CYCS/KIF5B/ITPR1/XBP1/RAB5A/ATG2A/PPP3CC/TBK1/SPG11/DCTN1/CALM2/PIK3C3/MAPK1/DAXX/BCL2/TUBB2A/APC/RAB39B/BAK1/BECN1/UBB/ATP2A2/EIF2AK3	-0.495573203860297
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/1202	63/9376	0.866703642078018	POLD4/RFC1/POLR2A/XPC/POLR2B/CCNH/DDB2	-0.407065514687034
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/1202	63/9376	0.866703642078018	GADD45B/LEF1/CDKN1A/TCF7/DDB2/APC/BAK1	-0.407065514687034
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/1202	97/9376	0.884573820265194	GNG2/GNAI2/PRKCB/PER1/ADCY3/CREB1/PRKACB/ITPR1/CALM2/MAPK1/FOS	-0.438187674242906
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1202	28/9376	0.835749940575232	PPT1/ELOVL5/HADHA	-0.333768813219335
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/1202	116/9376	0.87417522519938	GNG2/GNAI2/GLS/PRKCB/SLC38A2/GLUL/SLC38A1/ADCY3/PRKACB/ITPR2/ITPR1/PPP3CC/MAPK1	-0.522889858098381
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/1202	56/9376	0.835749940575232	MGAT4A/FUT8/ST6GAL1/ALG13/B4GALT1/RPN1	-0.472728894099822
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/1202	233/9376	0.903901223283083	FN1/VIM/SYNE2/TPM3/ITGA4/FMNL1/SYNE1/LBR/ITGB1/TLN1/SPTAN1/ZYX/EMD/SUN2/MYH9/ATP1B3/FBN1/DIAPH1/BGN/CAPZA1/LMNB1/FMNL3/ATP1A1/TMOD3/DAAM1/PLEC/DCN	-0.569602668656534
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/1202	57/9376	0.821087660916017	ACADM/ACSL3/PPT1/ELOVL5/HADHA/CPT1A	-0.519533577143099
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1202	30/9376	0.780033277870216	NFKB1/IL1B/TNF	-0.462727464862773
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	22/1202	195/9376	0.880037544263834	ITGB2/NFKB1/CYBA/FCGR3A/PIK3R1/SELPLG/PRKCB/CASP4/ITGAL/CASP1/RAC2/GSDMD/NCF1/NCF2/C5AR1/HDAC7/PIK3CA/PIK3CD/HDAC3/MAPK1/FCGR2A/FCGR1A	-0.649139766407239
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1202	31/9376	0.754870914067951	FBP1/G6PD/PRPS1	-0.524211561599624
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/1202	59/9376	0.793254180884966	TYMP/DPYD/DCK/NT5C3A/UPP1/ENTPD4	-0.610865009408547
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/1202	50/9376	0.780033277870216	AOC1/SAT1/LAP3/AMD1/ODC1	-0.598018797138882
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1202	23/9376	0.678289806843666	GLS/GLUL	-0.592343773415253
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1202	23/9376	0.678289806843666	B3GAT1/B4GALT1	-0.592343773415253
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1202	23/9376	0.678289806843666	IDI1/GGPS1	-0.592343773415253
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1202	23/9376	0.678289806843666	POLD4/RFC1	-0.592343773415253
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1202	43/9376	0.725612351507178	ACADM/ACSL3/HADHA/CPT1A	-0.691526309946533
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1202	13/9376	0.600025598361705	RAD50	-0.55337166441479
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/1202	54/9376	0.722253035065015	SDS/AMD1/MAT2A/MAT2B/DNMT3A	-0.784896166338811
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	22/1202	205/9376	0.837108883568037	CTSD/NFKB1/CYBA/MT-ND5/TGFB1/TGFBR2/PIK3R1/MT-ND4L/PRKCB/MMP9/MT-ND2/RAC2/MT-ND6/TBC1D4/NCF1/MT-ATP8/G6PD/NCF2/PIK3CA/PIK3CD/ATP2A2/PARP1	-0.904245880797523
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/1202	76/9376	0.718451703301515	FABP5/GK/ACADM/ACSL3/LPL/CYP27A1/CPT1A	-0.945015172981072
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/1202	86/9376	0.725612351507178	PRKCB/VAMP2/ADCY3/CREB1/PRKACB/ATP1B3/ATF2/ATP1A1	-0.980226595842658
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1202	27/9376	0.577802428052012	OXCT1/HADHA	-0.842433423040567
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1202	28/9376	0.557166627050155	B3GNT2/B4GALT1	-0.899871633903938
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	13/1202	134/9376	0.756748702411404	PPP1R12A/ROCK1/PRKCB/ADCY3/PRKCH/MYH9/PRKACB/ITPR2/PRKCQ/GNA13/ITPR1/CALM2/MAPK1	-1.08753974628143
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/1202	39/9376	0.600025598361705	MTHFD2/MAT2A/MAT2B	-0.959801395031327
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1202	79/9376	0.691168727226774	VAMP2/DNM2/ATP6V0B/TCIRG1/CLTB/NAPA/AP2B1	-1.05702183044337
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	42/1202	388/9376	0.844365919344049	APOE/TUBA4A/NFKB1/MT-ND5/PIK3R1/MT-ND4L/EIF2AK2/RB1CC1/CAPN2/MT-ND2/CASP8/IL1B/MT-ND6/DDIT3/KRAS/ITPR2/CSNK2B/CASP3/TUBA1A/MT-ATP8/MAP2K7/TNF/LPL/FAS/NRBF2/CYCS/KIF5B/ITPR1/XBP1/PIK3CA/ATG2A/PPP3CC/ADAM10/PIK3CD/CALM2/PIK3C3/MAPK1/TUBB2A/APC/BECN1/ATP2A2/EIF2AK3	-1.20063110597904
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1202	29/9376	0.53795398473808	RGS9/CALM2	-0.955583543860226
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1202	17/9376	0.458843104629539	CYP27A1	-0.856354312165152
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1202	17/9376	0.458843104629539	ADO	-0.856354312165152
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1202	51/9376	0.611790806172719	PAFAH1B1/PLA2G7/LPCAT4/PLD3	-1.06597504945644
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/1202	51/9376	0.611790806172719	ADCY3/PRKACB/ATP6V0B/TCIRG1	-1.06597504945644
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1202	30/9376	0.520022185246811	PIGX/PIGT	-1.00969326296582
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1202	18/9376	0.433351821039009	ACSL3	-0.922738804997946
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/1202	31/9376	0.503247276045301	DPYD/HADHA	-1.06231180262853
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1202	54/9376	0.577802428052012	USP1/REV3L/ATR/WDR48	-1.19310486700404
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1202	32/9376	0.487520798668885	GALM/B4GALT1	-1.11353885124251
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/1202	105/9376	0.668599952460185	TPM3/ITGA4/TGFB1/ITGB1/EMD/ADCY3/PRKACB/TNF/ATP2A2	-1.3094969183261
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/1202	20/9376	0.390016638935108	CYB5R4	-1.04714888645892
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1202	115/9376	0.678289806843666	DUSP1/GNG2/GNAI2/PRKCB/PRKACB/KRAS/ITPR2/CASP3/ITPR1/MAPK1	-1.33108366813781
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	25/1202	254/9376	0.767749289242339	CXCR4/ORAI1/CD38/PRKCB/STIM2/NFATC3/NFATC2/ADCY3/PTK2B/PRKACB/ITPKB/ITPR2/ATP2B1/F2R/ATP2B4/CAMK4/TFEB/ITPR1/PPP3CC/MCOLN2/CALM2/STIM1/NFATC1/P2RX5/ATP2A2	-1.43896235178149
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1202	21/9376	0.371444418033436	DPYD	-1.10573738754405
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/1202	99/9376	0.630329921511286	TPM3/ITGA4/TGFB1/ITGB1/PRKAG2/EMD/TNF/ATP2A2	-1.41791002812907
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1202	35/9376	0.445733301640124	FBP1/PFKFB3	-1.25972769511833
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1202	22/9376	0.354560580850098	AOC1	-1.16222094725919
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/1202	59/9376	0.528836120589977	LAP3/G6PD/GSTT1/ODC1	-1.39213227556794
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/1202	36/9376	0.433351821039009	POLD4/RFC1	-1.30620657351225
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/1202	48/9376	0.487520798668885	ACADM/OXCT1/HADHA	-1.36497013667244
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1202	37/9376	0.421639609659576	GLS/GLUL	-1.35166718957174
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1202	38/9376	0.410543830458009	HEXB/HEXA	-1.39616561028265
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	25/1202	268/9376	0.727642983087888	TUBA4A/NFE2L2/DUSP1/UBE2L6/MT-ND5/GNAI2/MT-ND4L/MT-ND2/MT-ND6/HSPA5/DDIT3/PRKACB/ITPR2/CASP3/TUBA1A/MT-ATP8/CYCS/KIF5B/ITPR1/XBP1/CALM2/DAXX/TUBB2A/UBB/EIF2AK3	-1.73466258052584
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/1202	52/9376	0.450019198771279	ADCY3/PRKACB/HSD17B7	-1.52499571755673
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/1202	75/9376	0.520022185246811	GLUL/SDS/MAT2A/MAT2B/PRPS1	-1.60032256514019
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/1202	86/9376	0.544209263630383	ITGA4/ITGB1/EMD/LEF1/TCF7/ATP2A2	-1.62827373747436
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/1202	27/9376	0.288901214026006	ELOVL5	-1.4188934853985
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/1202	149/9376	0.628214720432389	MT-ND5/GNG2/GNAI2/MT-ND4L/PRKCB/ADCY3/MT-ND2/MT-ND6/PRKACB/ITPR2/ITPR1/MAPK1	-1.75418591511721
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/1202	42/9376	0.371444418033436	AOC1/HADHA	-1.56550691334252
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/1202	89/9376	0.52586513114846	SPP1/FN1/CD44/ITGA4/ITGB1/CD47	-1.72337477261141
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/1202	28/9376	0.278583313525077	TCIRG1	-1.46597445458854
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/1202	29/9376	0.26897699236904	MOB1A	-1.51187010211389
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/1202	45/9376	0.346681456831207	TAP1/ABCB1	-1.68456472583066
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	28/1202	308/9376	0.709121161700197	TUBA4A/MT-ND5/MT-ND4L/RB1CC1/POLR2A/EP300/MT-ND2/CREBBP/CASP8/MT-ND6/CREB1/CASP3/POLR2B/TUBA1A/MT-ATP8/MAP2K7/NRBF2/REST/CYCS/KIF5B/ITPR1/ATG2A/CLTB/DCTN1/PIK3C3/TUBB2A/BECN1/AP2B1	-1.99045463975842
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/1202	31/9376	0.25162363802265	GLUL	-1.60041204365745
NA	NA	hsa04981	Folate transport and metabolism	1/1202	31/9376	0.25162363802265	SLCO2B1	-1.60041204365745
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/1202	47/9376	0.331929054412858	ACYP2/ME2	-1.76065604628046
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/1202	32/9376	0.243760399334443	HADHA	-1.64319288275884
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/1202	128/9376	0.548460898502496	PDE4B/PDE3B/PDE4D/ADCY3/DCK/PDE7A/PRPS1/ENTPD4/ENPP4	-1.97240908431132
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/1202	85/9376	0.458843104629539	TYMP/DCK/NT5C3A/UPP1/ENTPD4	-1.92186104832023
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/1202	183/9376	0.596746769955357	XRN1/SBDS/NXT1/XRN2/CSNK2B/WDR43/WDR36/LSG1/NOP56/TCOF1/NOP58/REXO1/PWP2/MPHOSPH10	-2.11249322557325
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1202	90/9376	0.433351821039009	ADCY3/PRKACB/ATP1B3/ABCB1/ATP1A1	-2.07129028313923
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/1202	103/9376	0.454388317205951	SLC38A2/COL15A1/ATP1B3/SLC3A2/ATP1A1/COL17A1	-2.13507285385321
NA	NA	hsa04081	Hormone signaling	17/1202	219/9376	0.605505284191492	CSH1/GNG2/GNAI2/CSH2/PIK3R1/STAT3/STAT5A/ADCY3/IGF2/STAT5B/PRKACB/GNA13/HAMP/POMC/SMAD4/PIK3CA/PIK3CD	-2.26520335376809
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/1202	67/9376	0.349268631882186	GALM/FBP1/ADPGK	-2.04978440048985
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/1202	191/9376	0.571752140847279	GNG2/GNAI2/GRB2/CREB1/PRKACB/KRAS/CAMK4/ATF2/HDAC7/SOS2/CALM2/HDAC3/MAPK1/SOS1	-2.29294089038093
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/1202	82/9376	0.380504037985471	TYMP/DPYD/GSTT1/UPP1	-2.1605515226067
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1202	41/9376	0.190252018992736	SDS	-1.99253150227137
NA	NA	hsa04519	Cadherin signaling	35/1202	404/9376	0.675771404095484	NFKBIA/VIM/NFKB1/MAP2K3/KRT86/ROCK1/KRT81/TAOK3/ARPC2/EP300/LEF1/RAC2/CREBBP/PTK2B/YWHAZ/NCKAP1L/KRAS/TMC8/MOB1A/MYO1F/ARHGAP35/SHOC2/VAV1/MYO1G/ACTR2/ADAM10/DAAM1/CYFIP2/YWHAQ/TCF7/MAPK1/APC/TMC6/ACTN4/LHFPL2	-2.55457066668199
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/1202	87/9376	0.358635989825387	TPM3/ATP1B3/ATP1A1/ATP2A2	-2.30462509327723
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/1202	138/9376	0.452193204562444	MT-ND5/MT-ND4L/MT-ND2/MT-ND6/MT-ATP8/ATP6V0B/TCIRG1/CYCS	-2.48598517759319
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/1202	116/9376	0.40346548855356	FBP1/SDS/ADPGK/G6PD/ME2/PRPS1	-2.47901771757814
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1202	46/9376	0.169572451710917	FTL	-2.16501244526832
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/1202	63/9376	0.247629612022291	HPGD/LTA4H	-2.29761745926085
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/1202	66/9376	0.236373720566732	HSD17B11/HSD17B7	-2.38725355317099
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/1202	83/9376	0.281939738989235	ACSL3/PEX1/PEX2	-2.51966338835839
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/1202	70/9376	0.111433325410031	GSTT1	-2.86139670286394
NA	NA	hsa04082	Neuroactive ligand signaling	10/1202	199/9376	0.391976521542822	GNG2/GNAI2/PRKCB/OGFR/ADCY3/TAC3/PRKACB/POMC/P2RY11/P2RX5	-3.32442911616267
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/1202	73/9376	0.106853873680852	GSTT1	-2.9376022618178
NA	NA	hsa04382	Cornified envelope formation	11/1202	217/9376	0.395408574035594	KRT86/PPP2R5C/KRT81/PPP2R2B/S100A8/S100A4/COL17A1/PPP2R2A/PLEC/PPP2R3C/PPP2R5A	-3.45532081745112
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/1202	79/9376	0.0987383896038248	GSTT1	-3.08470443609781
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1202	86/9376	0.0907015439383972	PRKACB	-3.24839159155361
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	20/1202	370/9376	0.421639609659576	CSH1/NR3C1/PTGER4/CSH2/TSPO/UTS2/OGFR/P2RY8/P2RY10/S1PR5/TAC3/F2R/GPR35/POMC/C5AR1/S1PR4/P2RY11/P2RX5/LPAR2/S1PR1	-4.35265242164583
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/1202	154/9376	0.151954534650042	MTHFD2/MAT2A/MAT2B	-4.06899815625811
Genetic Information Processing	Translation	hsa03010	Ribosome	5/1202	222/9376	0.17568317069149	RPS29/RPL28/RPL36AL/MRPS5/RPS21	-4.76634807927165
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1202	449/9376	0.104236072766621	RGS2/ADCY3/PRKACB/CALM2/ARRB2/NCALD	-7.45906733583496