category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	165/3000	250/9376	2.06272	CTSD/GNPTG/CTSC/CD68/SCARB2/CD63/CTSS/LAPTM5/CTSO/NEU1/ATP6V0D1/LAPTM4A/CTSA/NAGLU/ASAH1/PLA2G15/AP2M1/ACP5/ROGDI/HEXA/CTSZ/DEPTOR/FUCA2/PPT1/ARL8A/CLCN7/LAPTM4B/M6PR/LIPA/HYAL2/DMXL2/ATP6V1G1/HEXB/SLC11A1/ACP2/CTSB/CTBS/GUSB/IGF2R/TPP1/SMPD1/GLA/SLC15A3/VPS35/MANBA/GALNS/RRAGD/OSBPL1A/GGA2/AP1S2/ATP6V1C1/LGMN/GNS/MCOLN1/LAMP2/VPS13C/CLTC/SLC29A3/CTSF/BLOC1S6/TCIRG1/ATP6AP1/TPCN1/RRAGA/ATP6V0A1/MCOLN2/NAGA/SORT1/RRAGB/DNASE2/DMXL1/IDS/SLC11A2/SUMF1/GLB1/ATP6V0B/GPR155/NAGPA/RAB7A/LAMP1/ARSB/SLC17A5/NPC1/PIKFYVE/AP2A1/GGA1/SPG11/FUCA1/BLOC1S5/ZFYVE26/AP3M2/LAMTOR3/BLOC1S2/VPS16/HGSNAT/LITAF/MITF/ATP6V1B2/ENTPD4/TLR7/TMEM175/TFE3/ATP6V1D/RRAGC/VPS11/VAMP7/SNAPIN/SGSH/TELO2/CLN8/PSAP/TLR3/MFSD8/VPS18/STX17/GALC/AP3M1/GNPTAB/AP1G1/TLR8/VPS41/OSBPL2/BLOC1S1/MLST8/AP2B1/SLC2A6/AP4S1/CTNS/ARSA/ATP6V1H/AP5Z1/AP1M1/ABCA2/AP2S1/PLEKHM1/FIG4/TFEB/CTSH/AP3D1/AP2A2/SLC15A4/ABCA5/AP5M1/WDR7/GGA3/ARL8B/AKT1S1/VPS39/TPCN2/MCOLN3/OSBP/IDUA/ATP6V0A2/BLOC1S3/OSBPL5/AP5S1/VPS33A/LAMTOR5/MAN2B1/OSBPL7/AP4B1/MTOR/AP1G2/AP4M1/ATP6V0E1	11.6820951010372
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	104/3000	169/9376	1.92328205128205	GABARAPL2/CTSD/RRAS/IRS1/UBB/DAPK1/ITPR1/TSC2/OPTN/DEPTOR/PIK3R1/NBR1/CTSB/GABARAP/UVRAG/GABARAPL1/RB1CC1/IGF1R/PDPK1/KRAS/PPP2CB/EIF2AK4/RRAGD/WIPI2/PRKACA/AKT2/MAPK1/MRAS/LAMP2/STK11/PIK3CA/PRKACB/DDIT4/BCL2/RRAGA/GORASP2/SUPT20H/ULK2/RRAGB/CALCOCO2/CFLAR/RAB7A/LAMP1/PTEN/BCL2L1/WDFY3/TAX1BP1/PRKAA1/VPS16/C9orf72/SQSTM1/PIK3C3/RRAGC/STX7/HIF1A/VPS11/ULK1/ATG7/RPS6KB1/RAF1/PRKCD/RHEB/CAMKK2/WDR45/BIRC6/MTMR3/MTMR14/ATG14/VPS18/STX17/MAP3K7/RAB33B/MAP1LC3B/VPS41/MAPK8/WDR41/MLST8/ATG4B/EIF2AK3/EPG5/TSC1/PIK3R4/ATG4D/PLEKHM1/ATG16L2/ATG2B/VMP1/AMBRA1/SH3GLB1/ZFYVE1/PIK3CD/TRAF6/AKT1S1/VPS39/AKT3/RAB1A/ATG2A/VPS33A/MAPK10/ATG4A/PIK3R2/ERN1/MTOR/DAPK3	8.30789090566101
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	127/3000	224/9376	1.77195238095238	HLA-B/CCND2/HLA-A/CREB3L1/TNFRSF1A/HLA-DRA/TGFBR1/TGFBR2/MSX1/HLA-F/HLA-DPA1/HLA-DPB1/ADCY3/HLA-DMA/B2M/HLA-DMB/CREBBP/HLA-C/CCND3/HLA-DQA2/ITGB2/HLA-DQA1/HLA-DRB1/NRP1/HLA-DQB1/IL1R1/CDKN1A/HLA-E/SPI1/PIK3R1/SMAD3/CD4/LTBR/ADCY9/JUN/CDK4/KRAS/NFATC4/ICAM1/NFATC3/SMAD4/ATM/PRKACA/AKT2/MAPK1/ADCY7/TGFB3/CREB1/NFKB1/CCND1/ATF2/PIK3CA/ZFP36/PRKACB/STAT5A/HLA-DOA/JAK3/NFATC2/PPP3CB/ELK4/MAP3K3/TGFB2/ATF6B/CHEK2/ITGAL/MMP7/MYC/PTEN/BCL2L1/TLN2/NFKBIA/NFKB2/MAP2K4/TSPO/XIAP/DLG1/PPP3CC/IL2RG/CDC16/RELB/CDC27/ANAPC16/MAP3K1/CREB3/CD40/RANBP3/MAD1L1/ANAPC13/KAT5/KAT2B/IKBKG/IKBKB/ADCY6/MAPK8/CRTC1/RELA/EGR2/RB1/FOS/ANAPC10/BAX/ATR/CREB5/VAC14/TRRAP/CDKN2B/PPP3R1/STAT5B/PIK3CD/ANAPC7/EP300/TCF3/AKT3/ETS1/NFATC1/IL6/MAPK10/CRTC3/TBP/CRTC2/PIK3R2/ELK1/TLN1/ANAPC2/ATF4/E2F1/CHUK	8.02100202272288
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	133/3000	250/9376	1.66267733333333	HLA-B/PDGFRA/HLA-A/TGFBR1/TGFBR2/BIN1/HLA-F/RAB11FIP1/ARAP1/HLA-C/RAB11FIP2/TFRC/AP2M1/HSPA1A/EHD2/ARFGAP3/HLA-E/SMURF2/SMAD3/CXCR4/FGFR2/IST1/WASL/ARRB2/IGF2R/IGF1R/RAB22A/ASAP1/VPS35/WIPF1/CAPZA2/AGAP3/PSD3/SNX1/SMAP2/CLTC/FGFR4/ZFYVE16/PLD1/HSPA1B/RAB5A/CYTH1/ARFGEF2/ARF1/RUFY1/GIT2/PML/USP8/ARAP3/RAB7A/ACAP2/CHMP1A/AP2A1/SH3GL3/HSPA6/ACAP3/CAV2/CHMP1B/KIF5B/VPS4A/LDLRAP1/ARRB1/PRKCI/RABEP1/VPS36/IL2RG/WWP1/VPS28/CYTH4/RUFY2/SMAP1/ARFGEF1/DNM1/DAB2/PDCD6IP/STAM2/FGFR3/RAB11FIP3/CYTH2/EPS15L1/CHMP5/ARFGAP1/AGAP1/ASAP2/RNF41/STAM/RAB11B/AP2B1/RAB5C/CCR5/RAB31/WIPF2/EHD4/AP2S1/PIP5K1C/ARFGAP2/CYTH3/GRK5/VPS37A/STAMBP/WIPF3/SH3GLB1/AP2A2/CHMP6/AGAP6/VPS4B/HGS/ACAP1/EHD1/TRAF6/VPS45/ARAP2/EEA1/NEDD4L/SNX12/ZFYVE27/RAB35/SRC/SNX6/PIP5K1A/GBF1/NEDD4/VPS37B/ITCH/CHMP7/MVB12B/ZFYVE9/VPS37D/PLD2/RAB5B/PARD3/GRK4/PARD6G	7.28457131634085
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	75/3000	119/9376	1.96974789915966	VCAM1/CREB3L1/TNFRSF1A/CSF1/JAG1/RHBDF1/MAPK14/VEGFC/PIK3R1/MMP9/JUN/CYLD/FAS/JUNB/RHBDF2/ICAM1/TRADD/AKT2/MAPK1/SOCS3/CREB1/TAB2/BCL3/NFKB1/ATF2/PIK3CA/TNFRSF1B/BIRC3/BIRC2/RIPK1/CXCL3/CFLAR/ATF6B/CEBPB/NFKBIA/MAP2K4/XIAP/MAP3K8/CASP7/CXCL2/CREB3/RPS6KA4/CXCL10/MAP3K7/IKBKG/IKBKB/PTGS2/MAPK8/RELA/FOS/MAP2K7/IL18R1/BAG4/TRAF1/CREB5/TNFAIP3/RIPK3/PIK3CD/FADD/MLKL/CCL20/CASP3/AKT3/IL6/MAPK10/TRAF5/ITCH/CASP10/CCL5/PIK3R2/CXCL1/TAB3/ATF4/LIF/CHUK	7.30246203231469
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	103/3000	181/9376	1.77850460405157	MRC2/TNFRSF1A/HLA-DRA/CTSD/HLA-DPA1/CD74/HLA-DPB1/CALM2/CTSS/FCGR3A/HLA-DMA/HLA-DMB/CREBBP/ATP6V0D1/IL18/HLA-DQA2/IFNGR2/LSP1/ITGB2/HLA-DQA1/HLA-DRB1/MAPK14/HLA-DQB1/CAMK2D/FCER1G/FCGR1A/ITGAX/TRADD/VDR/MALT1/AKT2/MAPK1/IL10RB/TGFB3/CREB1/LAMP2/FCGR2A/SYK/NFKB1/BID/TCIRG1/PLK3/HLA-DOA/ATP6AP1/ITGAM/BCL2/RAB5A/ATP6V0A1/IFNGR1/JAK2/PPP3CB/CAMK2A/TLR1/ATP6V0B/IL10/TLR2/TGFB2/RAB7A/LAMP1/CEBPB/ARHGEF12/SPHK1/CIITA/PIK3C3/PPP3CC/TLR4/CORO1A/NFYC/RAF1/CARD9/PLA2R1/IRAK4/RFX5/KSR1/MAPK8/RELA/RFXANK/RAB5C/ATP6V1H/CD14/IRAK1/BAX/TLR6/RFXAP/PPP3R1/FADD/TRAF6/EP300/CASP3/EEA1/APAF1/AKT3/CLEC7A/ATP6V0A2/SRC/IL6/C3/MAPK10/CASP10/FCGR2B/SPHK2/RAB5B/CLEC4E	7.25432013725604
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	128/3000	248/9376	1.6130752688172	TNFRSF1A/S100A10/AHNAK/CASP1/RRAS/LY96/IL18/DYNLT3/PFN2/MAPK14/ARL8A/PKN1/M6PR/PLEKHM2/JUN/RHOB/WASL/ACTR10/NCKAP1L/PTPRC/RAB9A/TRADD/SNX18/ROCK2/AKT2/MAPK1/DYNC1LI2/TAB2/NFKB1/TUBB2A/DYNC2H1/PIK3CA/EXOC7/BIRC3/BCL2/RAB5A/FLNA/CYTH1/ARF1/STX10/BIRC2/RIPK1/FHOD1/RHOG/TLR2/RAB7A/TUBA1A/MYC/PYCARD/SNX9/VPS16/KIF5B/NFKBIA/FYCO1/PIK3C3/MAP2K4/HSP90B1/TLR4/KLC1/DCTN6/KPNA3/CASP7/DYNC1H1/TCF7L1/CYTH4/ACBD3/VPS11/ELMO1/RAF1/ABI1/TLR5/NCKAP1/CYTH2/VPS18/MAP3K7/IRAK4/IKBKG/IKBKB/VPS41/MAPK8/RELA/FOS/RAB5C/GCC2/NAIP/CD14/IRAK1/MAP2K7/BAX/DYNC2LI1/CYTH3/ELMO2/PLEKHM1/EXOC5/TLR6/RILP/DCTN3/TUBA3D/RIPK3/SNX33/NOD1/KLC4/EXOC4/PIK3CD/FADD/MLKL/ARL8B/DCTN4/NLRP3/TRAF6/VPS39/TNFRSF10B/TUBA4A/CASP3/DYNLT1/AKT3/DYNLRB1/TNFRSF10A/IL6/EXOC2/VPS33A/MAPK10/RHOH/MYL9/KPNA1/TAB3/RAB5B/CHUK	6.71156705105017
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	54/3000	83/9376	2.03334939759036	CREBBP/PCGF5/CBX6/USP7/CBX4/SCML1/PHC3/PHF19/FBRS/MAX/PHC2/ASXL2/ASXL1/PHF1/CBX8/RYBP/FOXK1/RING1/PCGF2/E2F6/KDM2A/MBD6/EZH1/USP16/DCAF7/SCMH1/MGA/BCOR/OGT/UBE2D2/L3MBTL4/KDM2B/CSNK2B/WDR5B/BAP1/YY1/YAF2/LCOR/ASXL3/CBX7/SFMBT2/EP300/FOXK2/PCGF3/MBD5/FBRSL1/JARID2/BMI1/AUTS2/AEBP2/HCFC1/PCGF1/PHC1/BCORL1	6.486051304471
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	64/3000	105/9376	1.90496507936508	GABARAPL2/AMFR/RRAS/UBB/FOXO3/OPTN/BNIP3L/SMURF2/NBR1/GABARAP/GABARAPL1/JUN/KRAS/MRAS/TBC1D15/RAB5A/PINK1/USP8/CALCOCO2/RAB7A/RHOT1/BCL2L1/TAX1BP1/MUL1/SP1/SQSTM1/MITF/TFE3/CSNK2A1/ARIH1/HIF1A/CCZ1/ULK1/FKBP8/RHOT2/NLRX1/MAP1LC3B/MTX2/CSNK2A2/CITED2/MAPK8/RELA/RAB5C/SAMM50/FUNDC1/EIF2AK3/MFN2/CSNK2B/AMBRA1/TFEB/TBC1D17/MON1B/SIAH1/MTX3/OPA1/USP30/CCZ1B/SRC/MAPK10/MON1A/TOMM40L/ATF4/E2F1/RAB5B	6.39639523991547
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	144/3000	300/9376	1.50016	HGF/PDGFRA/TNFRSF1A/TGFBR1/TGFBR2/CSF1/FGF7/IGF2/VEGFA/RRAS/KITLG/PDGFC/MAPK14/HSPA1A/GADD45B/IL1R1/PDGFA/PRKCA/VEGFC/GDNF/MAPKAPK3/FGFR2/PDGFRB/FGF2/MAP3K2/DUSP2/FGFR1/JUN/ARRB2/CACNA2D1/IGF1R/FAS/KRAS/EFNA5/DUSP7/RAP1A/NFATC3/TRADD/PRKACA/MAP2K5/TAOK1/AKT2/MAPK1/DUSP1/MRAS/TGFB3/RPS6KA3/CDC25B/TEK/FGFR4/TAB2/NFKB1/JUND/ATF2/MAP4K3/HSPA1B/RASGRP3/TAOK2/PRKACB/FLNA/SOS1/ANGPT1/PPM1A/PPP3CB/MAX/DUSP10/MAPK7/RAC2/ELK4/MAP3K3/EREG/TGFB2/HSPA6/MYC/BDNF/LAMTOR3/ARRB1/NFKB2/MAP2K4/VEGFB/PTPN7/PPP3CC/CACNB4/MAP3K8/RELB/RAPGEF2/GADD45G/MAPKAPK2/MAP3K1/ARAF/RAF1/CACNA2D4/EFNA2/RPS6KA4/MAP3K12/HSPB1/FGFR3/PRKCB/MAP3K7/IRAK4/IKBKG/IKBKB/PLA2G4A/SOS2/MAPK8/DDIT3/RELA/STK4/CRK/NRTN/DUSP3/FOS/DUSP8/CD14/IRAK1/MAP3K11/MAP2K7/MEF2C/MAP4K4/FLT3LG/RAP1B/PPP3R1/TRAF6/NF1/CACNB2/CASP3/AKT3/PLA2G4C/CACNA1C/NFATC1/PPP5C/MAPK10/CACNA1G/NTRK2/CACNB3/MAP3K6/ELK1/MAPK8IP3/CACNB1/PSPN/ATF4/DUSP16/GNG12/CHUK	6.03940913384179
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	102/3000	196/9376	1.62644897959184	HLA-B/IL6ST/HLA-A/TNFRSF1A/HLA-F/CALM2/VEGFA/CREBBP/HLA-C/UBB/ITPR1/MAPK14/CDK6/LYN/CDKN1A/HLA-E/PIK3R1/CD86/FGF2/GNG11/JUN/STAT3/GNB4/CDK4/FAS/KRAS/NFATC4/ICAM1/NFATC3/TRADD/AKT2/MAPK1/IFNAR1/CREB1/SYK/NFKB1/CCND1/CLEC2B/PIK3CA/BID/ZFP36/HCK/IFNGR1/ITPR2/JAK2/NFATC2/PPP3CB/PIK3R5/CXCL3/MYC/NFKBIA/PIK3C3/MAP2K4/PPP3CC/TCF7L1/HIF1A/MAPKAPK2/CXCL2/RAF1/TLR3/ATG14/IKBKG/MAP1LC3B/IKBKB/PTGS2/MAPK8/RELA/RB1/FOS/CCR5/MICA/MAP2K7/GNB2/PREX1/BAX/TICAM1/GNGT2/GSK3B/IKBKE/PPP3R1/PIK3CD/PLCG2/FADD/MICB/EP300/CASP3/AKT3/GNB3/SRC/NFATC1/IL6/TYK2/C3/MAPK10/PIK3R2/PLCG1/CXCL1/MTOR/E2F1/GNG12/GNGT1/CHUK	6.0794531022922
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	62/3000	105/9376	1.84543492063492	VCAM1/TNFRSF1A/TNFSF13B/LY96/GADD45B/LYN/IL1R1/UBE2I/LTBR/CYLD/ICAM1/TRADD/ATM/MALT1/SYK/TAB2/NFKB1/PLAU/BTK/BIRC3/BCL2/BIRC2/RIPK1/CXCL3/CFLAR/BCL2L1/ERC1/BCL2A1/NFKBIA/NFKB2/XIAP/TLR4/EDA/CSNK2A1/RELB/GADD45G/CXCL2/CD40/LAT/PRKCB/MAP3K7/IRAK4/IKBKG/CSNK2A2/IKBKB/PTGS2/RELA/CD14/IRAK1/TRAF1/TICAM1/CSNK2B/TNFAIP3/TNFSF14/PLCG2/TRAF6/TRAF5/PIAS4/PLCG1/CXCL1/TAB3/CHUK	5.97562936439666
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	109/3000	216/9376	1.57713580246914	CD36/VCAM1/TNFRSF1A/CALM2/CASP1/LY96/IL18/ABCA1/NCF2/ITPR1/MAPK14/HSPA1A/VLDLR/OLR1/LYN/PRKCA/CAMK2D/PIK3R1/MMP9/CYBB/JUN/STAT3/NFE2L2/PDPK1/FAS/KRAS/ICAM1/RAP1A/NFATC3/ROCK2/AKT2/MAPK1/MIB1/PLCB1/TAB2/NFKB1/PIK3CA/BID/HSPA1B/RXRB/BCL2/JAK2/NFATC2/PPP3CB/CAMK2A/CXCL3/TLR2/HSPA6/BCL2L1/PYCARD/NFKBIA/ABCG1/MAP2K4/ATF6/HSP90B1/PPP3CC/TLR4/POU2F2/CASP7/PLCB2/VAV1/CXCL2/CD40/NOS3/MAP3K7/IRAK4/IKBKG/IKBKB/MAPK8/DDIT3/RELA/FOS/CD14/IRAK1/EIF2AK3/MAP2K7/BAX/TICAM1/POU2F1/TLR6/GSK3B/IKBKE/NCF4/RAP1B/PPP3R1/PIK3CD/NLRP3/TRAF6/TNFRSF10B/CASP3/APAF1/AKT3/SOD2/SRC/NFATC1/TNFRSF10A/IL6/MAPK10/CCL5/RXRA/PIK3R2/CYBA/ERN1/PLCG1/CXCL1/ATF4/MIB2/CCL3/CHUK	5.88612209812299
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	65/3000	112/9376	1.81380952380952	LAMA2/TNFRSF1A/HLA-DRA/LAMB2/LAMC3/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DMB/SOCS1/LY96/HLA-DQA2/IFNGR2/HLA-DQA1/HLA-DRB1/MAPK14/HSPA1A/HLA-DQB1/GNAI1/GNAI2/STAT3/ALOX5/PDPK1/AKT2/MAPK1/IL10RB/TGFB3/TAB2/NFKB1/HSPA1B/BIRC3/HLA-DOA/BCL2/IFNGR1/BIRC2/JAK2/PIK3R5/IL10/TLR2/TGFB2/HSPA6/BCL2L1/NFKBIA/CIITA/XIAP/TLR4/LAMB1/CD40/LAMC1/MAP3K7/IRAK4/IKBKG/IKBKB/MAPK8/RELA/BIRC7/CCR5/IRAK1/TRAF6/CASP3/AKT3/TYK2/MAPK10/LAMB3/CHUK	5.94298477268731
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	113/3000	227/9376	1.55578267254038	HLA-B/PDGFRA/HLA-A/CREB3L1/TNFRSF1A/HLA-F/IL6R/CALM2/ADCY3/B2M/VEGFA/HLA-C/ITPR1/MAPK14/CDK6/IL1R1/TSC2/CDKN1A/PRKCA/HLA-E/PIK3R1/GNAI1/GNAI2/CXCR4/GNA13/PTGER2/GNG11/ADCY9/EIF4EBP1/STAT3/PTGER4/ROCK1/GNB4/BCAR1/CDK4/FAS/KRAS/NFATC4/NFATC3/TRADD/ROCK2/PRKACA/AKT2/MAPK1/IL10RB/ADCY7/TAPBP/CREB1/PTGER1/PLCB1/NFKB1/CCND1/ATF2/AKAP13/PIK3CA/BID/PRKACB/SOS1/ITPR2/RIPK1/NFATC2/PPP3CB/RAC2/TAPBPL/ATF6B/ARHGEF11/MYC/ARHGEF12/SP1/NFKBIA/PPP3CC/PLCB2/CREB3/RPS6KB1/RAF1/RHEB/PRKCB/IKBKG/IKBKB/PTGS2/ADCY6/SOS2/RELA/CRK/RB1/CCR5/GNB2/TSC1/BAX/GNA11/CREB5/GNGT2/GSK3B/PPP3R1/PIK3CD/FADD/CASP3/AKT3/GNB3/SRC/NFATC1/IL6/TRAF5/CCL5/PIK3R2/ELK1/MTOR/ATF4/E2F1/CCL3/GNG12/GNGT1/CHUK	5.81437755251086
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	84/3000	157/9376	1.67215286624204	CD36/EPOR/PROS1/LRP1/CASP1/ABCA1/PLA2G15/MAPK14/CAMK2D/BSG/AXL/THBS1/HAVCR2/TMEM30A/GAS6/LIPA/GULP1/SIRPA/PTGER2/DUSP2/PTGER4/ADAM10/ITGB5/BCAR1/ALOX5/NFATC4/DUSP7/NFATC3/C1QB/MAPK1/C1QA/CREB1/NR1H3/CPT1A/RAB14/ATP11B/C1QC/RAB5A/JAK2/NFATC2/PBX1/CAMK2A/IL10/RAB7A/CEBPB/VPS16/MERTK/SPHK1/PTPN6/SIRPB1/ANO6/CASP7/CD47/HIF1A/MAPKAPK2/VPS11/DNMT3A/ELMO1/ADAM9/VPS8/GPR132/TGFBRAP1/VPS18/SIRT1/PTGS2/VPS41/CRK/SIGLEC10/DUSP8/RAB5C/ATP2A2/XKR8/TYRO3/VPS39/CASP3/DOCK1/SGK1/NFATC1/VPS33A/RXRA/SPHK2/ATP2A3/DUSP16/RAB5B	5.82569957808549
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	77/3000	142/9376	1.69472300469484	TNFRSF1A/TGFBR1/TGFBR2/CSF1/TREM2/FCGR3A/SOCS1/IFNGR2/NCF2/ITPR1/MAPK14/TYROBP/ACP5/IL1R1/SPI1/PIK3R1/LILRB4/SIRPA/JUN/FYN/OSCAR/CYLD/FCGR1A/JUNB/AKT2/MAPK1/IFNAR1/SOCS3/CREB1/FCGR2A/SYK/TAB2/NFKB1/JUND/PIK3CA/BTK/LCP2/IFNGR1/ITPR2/LILRB1/NFATC2/PPP3CB/TNFRSF11B/LILRB2/TMEM64/TGFB2/NFKBIA/SQSTM1/NFKB2/SIRPB1/PPP3CC/MITF/RELB/LILRB3/LILRA2/MAP3K7/IKBKG/IKBKB/MAPK8/RELA/FOS/MAP2K7/ATP2A2/NCF4/PPP3R1/PIK3CD/PLCG2/TRAF6/AKT3/NFATC1/TYK2/MAPK10/PIK3R2/CYBA/FCGR2B/ATP2A3/CHUK	5.72180467938171
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	103/3000	205/9376	1.57028943089431	HLA-B/CCND2/HLA-A/HLA-DRA/VIM/HLA-F/HLA-DPA1/CD44/HLA-DPB1/HLA-DMA/B2M/RBPJ/HLA-DMB/HLA-C/CCND3/HLA-DQA2/HLA-DQA1/HLA-DRB1/MAPK14/GADD45B/CDK6/HLA-DQB1/LYN/CDKN1A/HLA-E/PIK3R1/USP7/HES1/JUN/STAT3/CDK4/CD58/FAS/POLK/ICAM1/TRADD/AKT2/CIR1/IFNAR1/TAPBP/SYK/TAB2/NFKB1/CCND1/PIK3CA/BID/BTK/SAP30L/HLA-DOA/BCL2/RIPK1/JAK3/NFKBIE/PSMC2/TAPBPL/TLR2/ITGAL/SAP30/DDB2/MYC/BCL2L11/NFKBIA/NFKB2/MAP2K4/CDKN1B/RELB/SIN3A/GADD45G/CD40/CXCL10/MAP3K7/IRAK4/IKBKG/NCOR2/IKBKB/MAPK8/RELA/RB1/IRAK1/RUNX3/MAP2K7/BAX/TNFAIP3/IKBKE/PIK3CD/PLCG2/PSMC6/FADD/TRAF6/CASP3/APAF1/AKT3/IL6/TYK2/OAS2/NEDD4/CD19/MAPK10/ENTPD1/TRAF5/PIK3R2/E2F1/CHUK	5.66286251897563
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	82/3000	155/9376	1.65340215053763	HLA-B/CD36/HLA-A/MRC2/HLA-DRA/COLEC12/HLA-F/HLA-DPA1/HLA-DPB1/CTSS/FCGR3A/HLA-DMA/MSR1/HLA-DMB/HLA-C/C1R/ATP6V0D1/HLA-DQA2/ITGB2/HLA-DQA1/HLA-DRB1/NCF2/TFRC/OLR1/HLA-DQB1/HLA-E/THBS1/M6PR/ATP6V1G1/CYBB/ITGB5/FCGR1A/ATP6V1C1/DYNC1LI2/LAMP2/FCGR2A/TUBB2A/DYNC2H1/TCIRG1/HLA-DOA/ATP6AP1/ITGAM/RAB5A/ATP6V0A1/MARCO/ATP6V0B/STX18/TLR2/RAB7A/LAMP1/PIKFYVE/TUBA1A/STX12/PIK3C3/TLR4/ATP6V1B2/THBS3/ATP6V1D/CORO1A/DYNC1H1/STX7/PLA2R1/RAB5C/ATP6V1H/CD14/SCARB1/TLR6/RILP/TUBA3D/NCF4/HGS/SEC61A1/TUBA4A/EEA1/CLEC7A/ATP6V0A2/C3/SEC61A2/CYBA/FCGR2B/RAB5B/ATP6V0E1	5.62638580838371
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	85/3000	163/9376	1.62977505112474	CREB3L1/TGFBR1/TGFBR2/CREBBP/MAPK14/CDKN1A/PRKCA/PIK3R1/SMAD3/MMP9/JUN/STAT3/STAT6/FAS/KRAS/NFATC4/NFATC3/SMAD4/AKT2/MAPK1/IFNAR1/TGFB3/CREB1/TAB2/NFKB1/ATF2/PIK3CA/BID/STAT5A/ATP6AP1/BCL2/SOS1/JAK3/JAK2/NFATC2/TLR2/TGFB2/ATF6B/DDB2/MYC/IFIH1/NFKBIA/MAP2K4/TLR4/MAP3K1/CREB3/ARAF/RAF1/TLR3/PRKCB/MAP3K7/IRAK4/IKBKG/IKBKB/SOS2/MAPK8/RELA/EGR2/RB1/FOS/IRAK1/MAP2K7/BAX/TICAM1/CREB5/IKBKE/STAT5B/PIK3CD/FADD/TRAF6/EP300/CASP3/APAF1/AKT3/SRC/NFATC1/IL6/TYK2/MAPK10/CASP10/PIK3R2/ELK1/ATF4/E2F1/CHUK	5.56353506783953
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	37/3000	56/9376	2.06495238095238	CCND2/GAS1/DISP1/CDON/SMURF2/SMO/ARRB2/SPOP/PRKACA/GLI2/CCND1/SUFU/PRKACB/BCL2/GLI3/SPOPL/FBXW11/ARRB1/CSNK1G3/BOC/GPR161/CUL3/MEGF8/CSNK1G2/BTRC/MGRN1/CSNK1D/GSK3B/SCUBE2/EVC2/EVC/PTCH1/KIF7/IQCE/CSNK1G1/PTCH2/EFCAB7	5.48262267049092
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	75/3000	142/9376	1.65070422535211	SOCS1/UBB/UBE2I/SMURF2/KLHL9/PIAS1/UBE3A/UBA7/RCHY1/UBE2L6/SOCS3/STUB1/UBE2E3/BIRC3/UBE2R2/BIRC2/CUL5/PML/CDC34/UBE2W/DDB2/PIAS2/KEAP1/FBXW11/XIAP/RHOBTB1/CDC16/SYVN1/UBE2E1/WWP1/CDC27/CUL7/ANAPC16/MAP3K1/UBE2Q1/TRIP12/CUL2/CUL3/BIRC6/ANAPC13/UBE2B/UBA6/UBE2E2/TRIM32/HERC2/UBA2/BIRC7/UBE2D2/FZR1/RHOBTB2/ANAPC10/PIAS3/HERC1/UBR5/BTRC/UBE4A/MGRN1/SIAH1/UBE4B/UBE2Z/UBE2J2/ANAPC7/TRAF6/UBE2G2/FBXW8/NEDD4L/UBE3B/DET1/FANCL/NEDD4/ITCH/PIAS4/WWP2/ANAPC2/UBOX5	5.35926183004207
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	48/3000	80/9376	1.8752	HGF/PDGFRA/IL6R/VEGFA/PDGFC/FOXO3/PDGFA/PRKCA/AXL/PIK3R1/GAS6/FGFR2/PDGFRB/FGF2/EIF4EBP1/STAT3/IGF1R/KRAS/AKT2/MAPK1/SHC2/PIK3CA/BCL2/SOS1/JAK2/PTEN/BCL2L1/BCL2L11/RPS6KB1/ARAF/RAF1/GAB1/SHC1/FGFR3/NRG2/PRKCB/SOS2/BAX/GSK3B/PIK3CD/PLCG2/NF1/AKT3/SRC/IL6/PIK3R2/PLCG1/MTOR	5.39232868410129
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	65/3000	120/9376	1.69288888888889	ARHGDIG/CALM2/IRS1/FOXO3/KIDINS220/ABL1/IRAK3/MAPK14/CAMK2D/PIK3R1/JUN/PDPK1/KRAS/FRS2/RAP1A/MAP2K5/AKT2/MAPK1/SHC2/RPS6KA3/NFKB1/PIK3CA/BCL2/SOS1/NFKBIE/SORT1/SH2B3/MATK/CAMK2A/MAPK7/MAP3K3/PSEN1/BDNF/SH2B1/NFKBIA/PSEN2/MAGED1/MAPKAPK2/MAP3K1/RAF1/GAB1/SHC1/PRKCD/IRAK4/IKBKB/SOS2/MAPK8/RELA/CRK/IRAK1/MAP2K7/BAX/GSK3B/RAP1B/PIK3CD/PLCG2/TRAF6/AKT3/ZNF274/MAPK10/PRDM4/NTRK2/PIK3R2/PLCG1/ATF4	5.23979937204865
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	46/3000	77/9376	1.86708225108225	TGFBR1/TGFBR2/ABL1/GADD45B/CDK6/CDKN1A/PIK3R1/SMAD3/CDK4/KRAS/POLK/SMAD4/AKT2/MAPK1/SHC2/TGFB3/NFKB1/CCND1/PIK3CA/STAT5A/SOS1/TGFB2/DDB2/MYC/BCL2L1/NFKBIA/CDKN1B/GADD45G/ARAF/RAF1/RUNX1/SHC1/IKBKG/IKBKB/SOS2/RELA/CRK/RB1/BAX/STAT5B/PIK3CD/CTBP2/AKT3/PIK3R2/E2F1/CHUK	5.24034218458621
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	60/3000	109/9376	1.72036697247706	IL6ST/HLA-DRA/TGFBR1/TGFBR2/HLA-DPA1/HLA-DPB1/IL6R/AHR/HLA-DMA/HLA-DMB/HLA-DQA2/IFNGR2/HLA-DQA1/HLA-DRB1/MAPK14/HLA-DQB1/IL1R1/SMAD3/IL4R/CD4/JUN/STAT3/STAT6/RARA/NFATC3/SMAD4/MAPK1/NFKB1/RXRB/STAT5A/HLA-DOA/IFNGR1/JAK3/NFKBIE/JAK2/NFATC2/PPP3CB/NFKBIA/PPP3CC/IL2RG/HIF1A/RUNX1/IL27RA/LAT/IKBKG/IKBKB/MAPK8/RELA/FOS/PPP3R1/STAT5B/IL12RB1/NFATC1/IL6/TYK2/MAPK10/RXRA/PLCG1/MTOR/CHUK	5.1888315476825
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	149/3000	333/9376	1.39842242242242	SPP1/HLA-B/CCND2/WNT2/HLA-A/LAMA2/CREB3L1/TNFRSF1A/LAMB2/VTN/FZD2/COL6A1/COL6A2/COL1A2/COL1A1/HLA-F/LAMC3/WNT2B/ITGA1/RBPJ/VEGFA/NOTCH2/WNT5B/CREBBP/HLA-C/CCND3/ATP6V0D1/JAG1/RBL2/CDK6/TSC2/CDKN1A/HLA-E/FZD1/PIK3R1/THBS1/FZD7/PDGFRB/ATP6V1G1/EIF4EBP1/APC/HES1/PTGER4/ITGB5/FN1/CDK4/UBE3A/RFNG/FAS/KRAS/PPP2CB/ITGA11/CHD4/TRADD/ATM/PRKACA/ATP6V1C1/MAML2/AKT2/MAPK1/IFNAR1/CREB1/NFKB1/CCND1/PIK3CA/TCIRG1/PRKACB/ATP6AP1/ATP6V0A1/SOS1/UBR4/LFNG/COL4A5/NFX1/ITGA4/TADA3/ATP6V0B/PPP2R5E/LLGL2/PSEN1/TNXB/DVL3/PTEN/DVL2/FZD4/PRKCI/DLG3/CDKN1B/DLG1/ATP6V1B2/THBS3/ATP6V1D/TCF7L1/MFNG/CREB3/LAMB1/RPS6KB1/COL6A6/RAF1/OASL/LAMC1/RHEB/MX2/FZD6/PPP2R2D/TUBG2/PPP2R3C/TLR3/IKBKG/IKBKB/PTGS2/SOS2/COL9A2/RELA/RB1/ATP6V1H/TSC1/BAX/PPP2R5A/TICAM1/ATR/CREB5/GSK3B/COL9A3/IKBKE/WNT11/PIK3CD/MAML1/FADD/EP300/ITGB7/CASP3/AKT3/ATP6V0A2/WNT3/PPP2R5B/TYK2/NOTCH1/LAMB3/TBP/PIK3R2/HEYL/MAML3/MTOR/E2F1/PARD3/ATP6V0E1/PARD6G/CHUK	5.07787182615537
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	53/3000	93/9376	1.78110394265233	MAF/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DMA/RBPJ/NOTCH2/HLA-DMB/HLA-DQA2/IFNGR2/HLA-DQA1/HLA-DRB1/JAG1/MAPK14/HLA-DQB1/IL4R/CD4/JUN/STAT6/NFATC3/MAML2/MAPK1/NFKB1/STAT5A/HLA-DOA/IFNGR1/JAK3/NFKBIE/JAK2/NFATC2/PPP3CB/NFKBIA/PPP3CC/IL2RG/LAT/IKBKG/IKBKB/MAPK8/RELA/FOS/RUNX3/DLL4/PPP3R1/STAT5B/MAML1/IL12RB1/NFATC1/TYK2/NOTCH1/MAPK10/MAML3/PLCG1/CHUK	5.19252074565448
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	80/3000	157/9376	1.59252653927813	HLA-B/CCND2/HLA-A/TGFBR1/TGFBR2/ZFP36L2/IGFBP3/HLA-F/CALM2/ZFP36L1/RRAS/HLA-C/CCND3/GATA4/CAPN2/FOXO3/ITPR1/RBL2/MAPK14/GADD45B/CDK6/HIPK3/TSC2/CDKN1A/HLA-E/HIPK2/PIK3R1/SMAD3/EIF4EBP1/CDK4/KRAS/NFATC4/NFATC3/ATM/RASSF5/AKT2/MAPK1/MRAS/TGFB3/NFKB1/CCND1/SERPINE1/PIK3CA/HIPK1/ITPR2/NFATC2/PPP3CB/TRPM7/TGFB2/CHEK2/MYC/PTEN/FBXW11/RAD50/SQSTM1/PPP3CC/NBN/GADD45G/MAPKAPK2/RAF1/E2F4/RHEB/SIRT1/RELA/RB1/TSC1/BTRC/ATR/CDKN2B/PPP3R1/PIK3CD/AKT3/ETS1/NFATC1/IL6/PIK3R2/MTOR/LIN52/E2F1/LIN54	5.1355603512878
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	70/3000	133/9376	1.64491228070175	CCND2/GABARAPL2/TGFBR1/TGFBR2/KLF2/CREBBP/IRS1/FOXO3/RBL2/MAPK14/GADD45B/CDKN1A/PIK3R1/SMAD3/USP7/CAT/GABARAP/GABARAPL1/STAT3/HOMER3/CCNG2/IGF1R/PDPK1/KRAS/SMAD4/ATM/AKT2/MAPK1/TGFB3/STK11/CCND1/PIK3CA/PLK3/SOS1/IL10/TGFB2/PTEN/BCL2L11/G6PC3/PRKAA1/CDKN1B/SGK3/GADD45G/CDKN2D/ARAF/RAF1/SETD7/IL7R/SIRT1/IKBKB/SOS2/MAPK8/STK4/S1PR4/PRKAG2/FBXO32/CDKN2B/PIK3CD/FBXO25/EP300/PRKAG1/BCL6/AKT3/SOD2/SGK1/IL6/MAPK10/PRKAB1/PIK3R2/CHUK	5.13797636758256
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	72/3000	138/9376	1.63060869565217	CASP1/IL18/MAPK14/PIK3R1/PKN1/CD4/JUN/WASL/ROCK1/BCAR1/FN1/WIPF1/NFATC3/ROCK2/AKT2/MAPK1/WASF2/RPS6KA3/FCGR2A/LIMK1/TAB2/NFKB1/PIK3CA/LCP2/GIT2/NFATC2/WAS/PKN2/ITGA4/RAC2/RHOG/IL10/PYCARD/ARHGEF12/NFKBIA/MAP2K4/TLR4/VAV1/ELMO1/LAT/MAP3K7/IRAK4/IKBKG/IKBKB/MAPK8/RELA/CRK/FOS/WIPF2/IRAK1/BAIAP2/MAP2K7/PIP5K1C/TICAM1/ELMO2/GSK3B/WIPF3/PIK3CD/NLRP3/TRAF6/AKT3/DOCK1/SRC/NFATC1/IL6/PIP5K1A/MAPK10/PIK3R2/SKAP2/PLCG1/ARHGEF7/CHUK	5.1189705460789
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	89/3000	180/9376	1.5453037037037	HLA-B/HLA-A/BST2/TNFRSF1A/HLA-DRA/HLA-F/HLA-DPA1/CD74/HLA-DPB1/HLA-DMA/B2M/HLA-DMB/HLA-C/HLA-DQA2/IFNGR2/HLA-DQA1/HLA-DRB1/HLA-DQB1/TSC2/HLA-E/TNFRSF14/PIK3R1/EIF4EBP1/FAS/TRADD/AKT2/IFNAR1/SOCS3/TAPBP/SYK/TAB2/NFKB1/PIK3CA/BID/BIRC3/HLA-DOA/HCFC2/BCL2/SP100/IFNGR1/BIRC2/JAK2/PML/TAPBPL/TLR2/IFIH1/BCL2L1/NFKBIA/POU2F2/RNASEL/CARD9/RHEB/TLR3/MAP3K7/IRAK4/IKBKG/IKBKB/RELA/PILRA/IRAK1/TSC1/BAX/TICAM1/POU2F1/EIF2B4/IKBKE/SRSF5/TNFSF14/PIK3CD/FADD/SRSF4/TRAF6/EIF2B1/CASP3/APAF1/AKT3/SRC/IL6/ZC3HAV1/TYK2/OAS2/NXF1/C3/TRAF5/CCL5/PIK3R2/HCFC1/MTOR/CHUK	5.06695829873061
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	56/3000	101/9376	1.73285808580858	F3/VCAM1/TGFBR1/TGFBR2/COL1A2/COL3A1/COL1A1/VEGFA/MAPK14/PRKCA/VEGFC/PIK3R1/SMAD3/CYBB/JUN/STAT3/FN1/CDK4/KRAS/ICAM1/SMAD4/AKT2/MAPK1/TGFB3/PLCB1/NFKB1/CCND1/SERPINE1/PIK3CA/STAT5A/BCL2/JAK2/COL4A5/PLCD3/TGFB2/VEGFB/CDKN1B/PLCB2/PRKCD/PLCE1/NOS3/PRKCB/MAPK8/RELA/BAX/STAT5B/THBD/PIK3CD/PLCG2/CASP3/AKT3/NFATC1/IL6/MAPK10/PIK3R2/PLCG1	5.07920478269392
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	71/3000	137/9376	1.61969829683698	TNFRSF1A/CTSD/CTSC/CTSS/CTSO/CAPN2/ITPR1/GADD45B/CTSZ/PIK3R1/SPTAN1/CTSB/JUN/PDPK1/FAS/KRAS/TRADD/ATM/AKT2/MAPK1/CTSF/NFKB1/PIK3CA/BID/BIRC3/BCL2/NOL3/ITPR2/BIRC2/RIPK1/LMNA/CFLAR/TUBA1A/BCL2L1/BCL2L11/BCL2A1/NFKBIA/XIAP/CASP7/BBC3/GADD45G/RAF1/IKBKG/PTPN13/IKBKB/MAPK8/DDIT3/RELA/HTRA2/FOS/EIF2AK3/PARP3/TRAF1/BAX/CTSH/TUBA3D/PIK3CD/FADD/TNFRSF10B/TUBA4A/CASP3/APAF1/AKT3/TNFRSF10A/MAPK10/CASP10/PIK3R2/ERN1/DIABLO/ATF4/CHUK	5.01187480515889
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	51/3000	90/9376	1.77102222222222	CREB3L1/SESN3/ADCY3/IRS1/FOXO3/TSC2/PIK3R1/ADCY9/CAT/EIF4EBP1/RB1CC1/IGF1R/KRAS/APPL1/PRKACA/AKT2/ADCY7/CREB1/SESN1/STK11/NFKB1/ATF2/PIK3CA/PRKACB/ATF6B/PRKAA1/ADIPOR1/ULK1/CREB3/RPS6KB1/RHEB/CAMKK2/EHMT2/SIRT1/ADCY6/RELA/TSC1/PRKAG2/BAX/CREB5/EHMT1/PIK3CD/AKT1S1/PRKAG1/AKT3/SOD2/PRKAB1/PIK3R2/MTOR/ATF4/SESN2	5.04133922810116
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	52/3000	93/9376	1.7474982078853	LAMA2/LAMB2/LAMC3/GADD45B/CDK6/CDKN1A/RARB/PIK3R1/FN1/CDK4/POLK/AKT2/NFKB1/CCND1/PIK3CA/RXRB/BIRC3/BCL2/BIRC2/COL4A5/MAX/DDB2/MYC/PTEN/BCL2L1/NFKBIA/XIAP/CDKN1B/GADD45G/LAMB1/LAMC1/IKBKG/IKBKB/PTGS2/RELA/RB1/BIRC7/TRAF1/BAX/CDKN2B/PIK3CD/TRAF6/CASP3/APAF1/AKT3/ZBTB17/TRAF5/LAMB3/RXRA/PIK3R2/E2F1/CHUK	4.96912093236176
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	51/3000	91/9376	1.75156043956044	CD81/IFITM1/LYN/PIK3R1/LILRB4/JUN/KRAS/NFATC3/MALT1/CD72/AKT2/MAPK1/SYK/NFKB1/PIK3CA/BTK/RASGRP3/SOS1/NFKBIE/LILRB1/NFATC2/PPP3CB/LILRB2/RAC2/PIK3AP1/NFKBIA/PTPN6/CD22/PPP3CC/VAV1/RAF1/LILRB3/LILRA2/PRKCB/INPP5D/IKBKG/IKBKB/SOS2/RELA/FOS/GSK3B/PPP3R1/INPPL1/PIK3CD/PLCG2/AKT3/NFATC1/CD19/PIK3R2/FCGR2B/CHUK	4.94157925610589
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	57/3000	105/9376	1.69660952380952	CALM2/CASP1/RRAS/LSP1/ITPR1/MAPK14/PIK3R1/FCER1G/JUN/CYLD/KRAS/NFATC4/NFATC3/MALT1/AKT2/MAPK1/MRAS/SYK/BCL3/NFKB1/PIK3CA/PLK3/ITPR2/NFATC2/PPP3CB/IL10/PYCARD/ARHGEF12/NFKBIA/NFKB2/PPP3CC/RELB/MAPKAPK2/RAF1/CARD9/PRKCD/IKBKG/IKBKB/PTGS2/KSR1/MAPK8/RELA/EGR2/IKBKE/PPP3R1/PIK3CD/PLCG2/NLRP3/AKT3/CLEC7A/SRC/NFATC1/IL6/MAPK10/PIK3R2/CHUK/CLEC4E	4.92371467559962
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	38/3000	62/9376	1.91552688172043	RBPJ/NOTCH2/CREBBP/JAG1/ATXN1/HES1/NUMB/RFNG/MAML2/CIR1/APH1A/LFNG/DTX3/PSEN1/DVL3/ATXN1L/DVL2/PSEN2/MFNG/KAT2B/NCSTN/NUMBL/NCOR2/PTCRA/APH1B/TLE4/DLL4/MAML1/SPEN/CTBP2/DTX3L/EP300/DTX2/NOTCH1/ITCH/HEYL/MAML3/NRARP	4.96101956635834
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	64/3000	122/9376	1.63951912568306	SLC16A10/DIO3/ATP1B1/NOTCH2/CREBBP/GATA4/THRA/MED13L/ATP1A1/TSC2/PRKCA/PIK3R1/NCOR1/PDPK1/KRAS/MED13/PFKM/PRKACA/AKT2/MAPK1/PLCB1/NCOA1/CCND1/PIK3CA/RXRB/ATP1A2/PRKACB/PLCD3/MED30/BMP4/MYC/HDAC3/NCOA2/SIN3A/PLCB2/HIF1A/RAF1/RHEB/PLCE1/MED1/KAT2B/PRKCB/MED14/MED4/MED27/ATP2A2/GSK3B/PIK3CD/PLCG2/SLC9A1/EP300/AKT3/SRC/NOTCH1/PFKFB2/RXRA/PIK3R2/PLCG1/TBC1D4/ATP1B3/MTOR/ATP2A3/MED17/MED12	4.87686592701184
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	64/3000	122/9376	1.63951912568306	CREB3L1/IGFBP3/ADCY3/SOCS1/CREBBP/IRS1/ITPR1/MAPK14/PRKCA/PIK3R1/GNAI1/GNAI2/ADCY9/STAT3/BCAR1/KRAS/JUNB/PRKACA/AKT2/MAPK1/SHC2/ADCY7/SOCS3/CREB1/PLCB1/ATF2/PIK3CA/SSTR1/SOCS2/PRKACB/STAT5A/SOS1/ITPR2/JAK2/ATF6B/CSH2/MAP2K4/CSH1/PLCB2/MAP3K1/CREB3/RAF1/SHC1/PRKCB/ADCY6/SOS2/MAPK8/GHR/CRK/FOS/GNA11/CREB5/GSK3B/STAT5B/PIK3CD/PLCG2/EP300/AKT3/CACNA1C/MAPK10/PIK3R2/PLCG1/MTOR/ATF4	4.87686592701184
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	45/3000	78/9376	1.80307692307692	HLA-DRA/HLA-DPA1/HLA-DPB1/FCGR3A/HLA-DMA/HLA-DMB/HLA-DQA2/IFNGR2/ITGB2/HLA-DQA1/HLA-DRB1/NCF2/MAPK14/HLA-DQB1/CYBB/JUN/FCGR1A/MAPK1/TGFB3/FCGR2A/TAB2/NFKB1/HLA-DOA/ITGAM/IFNGR1/JAK2/ITGA4/IL10/TLR2/TGFB2/NFKBIA/PTPN6/TLR4/PRKCB/MAP3K7/IRAK4/PTGS2/RELA/FOS/IRAK1/NCF4/TRAF6/C3/CYBA/ELK1	4.8851936976422
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	54/3000	99/9376	1.70472727272727	PDGFRA/PDGFC/TSC2/PDGFA/PRKCA/PIK3R1/PDGFRB/EIF4EBP1/JUN/PDPK1/KRAS/CHPT1/AKT2/MAPK1/WASF2/PLD1/RALGDS/PIK3CA/SOS1/SLC44A4/WAS/SLC22A3/RAC2/SP1/HIF1A/RPS6KB1/RAF1/RHEB/DGKH/GPCPD1/PRKCB/PLA2G4A/SOS2/MAPK8/CHKA/FOS/TSC1/PIP5K1C/CHKB/DGKQ/PIK3CD/PCYT1A/DGKD/SLC44A3/AKT3/PLA2G4C/DGKE/PIP5K1A/MAPK10/PIK3R2/PLCG1/MTOR/PLD2/DGKA	4.83511724115367
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	78/3000	158/9376	1.54288607594937	WNT2/TNFRSF1A/FZD2/WNT2B/WNT5B/IRS1/TSC2/PRKCA/DEPTOR/FZD1/PRR5/PIK3R1/LPIN2/FZD7/RICTOR/ATP6V1G1/EIF4EBP1/IGF1R/PDPK1/KRAS/RRAGD/ATP6V1C1/AKT2/MAPK1/RPS6KA3/STK11/LRP5/PIK3CA/FNIP2/DDIT4/RRAGA/SOS1/FNIP1/ULK2/LRP6/RRAGB/DVL3/PTEN/DVL2/LAMTOR3/FZD4/PRKAA1/CAB39/ATP6V1B2/ATP6V1D/RRAGC/ULK1/LPIN1/RPS6KB1/RAF1/TELO2/RHEB/FZD6/FLCN/PRKCB/IKBKB/SEC13/SOS2/MLST8/ATP6V1H/WDR24/TSC1/GSK3B/WDR59/WNT11/PIK3CD/AKT1S1/AKT3/NPRL3/WNT3/SGK1/NPRL2/LAMTOR5/PIK3R2/MTOR/PRR5L/SESN2/CHUK	4.72053265063338
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	156/3000	362/9376	1.34682872928177	PRLR/SPP1/HGF/CCND2/PDGFRA/LAMA2/CREB3L1/LAMB2/VTN/CSF1/FGF7/COL6A1/COL6A2/COL1A2/COL1A1/LAMC3/EPOR/IL6R/ITGA1/IGF2/VEGFA/KITLG/CCND3/IRS1/PDGFC/FOXO3/RBL2/OSMR/CDK6/TSC2/PDGFA/CDKN1A/PRKCA/LPAR1/VEGFC/PIK3R1/THBS1/PKN1/GDNF/FGFR2/PDGFRB/IL4R/FGF2/GNG11/FGFR1/EIF4EBP1/ITGB5/GNB4/FN1/CDK4/IGF1R/PDPK1/KRAS/PPP2CB/EFNA5/ITGA11/AKT2/OSM/MAPK1/IFNAR1/CREB1/TEK/STK11/FGFR4/SYK/NFKB1/CCND1/ATF2/PIK3CA/DDIT4/BCL2/SOS1/ANGPT1/JAK3/JAK2/COL4A5/PKN2/ITGA4/PIK3R5/YWHAH/PIK3AP1/EREG/TLR2/PPP2R5E/ATF6B/TNXB/MYC/PTEN/MAGI2/CSH2/BDNF/BCL2L1/BCL2L11/G6PC3/PRKAA1/VEGFB/CDKN1B/HSP90B1/TLR4/SGK3/THBS3/IL2RG/CSH1/CHRM2/CREB3/LAMB1/RPS6KB1/COL6A6/PHLPP2/RAF1/EFNA2/LPAR6/IL7R/LAMC1/RHEB/FGFR3/PPP2R2D/PPP2R3C/NOS3/IKBKG/LPAR5/IKBKB/SOS2/COL9A2/GHR/MLST8/RELA/NRTN/GNB2/TSC1/PPP2R5A/FLT3LG/CREB5/GNGT2/GSK3B/COL9A3/PIK3CD/THEM4/ITGB7/AKT3/GNB3/SGK1/IL6/PPP2R5B/CD19/LAMB3/NTRK2/RXRA/CRTC2/PIK3R2/PSPN/MTOR/ATF4/GNG12/GNGT1/CHUK	4.61617946272342
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	96/3000	204/9376	1.47074509803922	HGF/WNT2/GPC3/SDC2/VTN/FZD2/TIMP3/DCN/LUM/COL1A2/COL1A1/CD44/CD63/WNT2B/IGF2/VEGFA/WNT5B/RRAS/PLAUR/TWIST1/ITPR1/MAPK14/CDKN1A/PRKCA/CAMK2D/FZD1/PIK3R1/THBS1/SMO/FZD7/ANK2/MMP9/FGF2/FGFR1/STAT3/ITGB5/ROCK1/FN1/IGF1R/PDPK1/FAS/KRAS/HSPB2/FRS2/ROCK2/PRKACA/AKT2/MAPK1/MRAS/MSN/CCND1/PLAU/PIK3CA/PRKACB/FLNA/SOS1/HBEGF/ITPR2/CAMK2A/TLR2/TGFB2/MYC/ARHGEF12/FZD4/CAV2/PTPN6/TLR4/HIF1A/VAV1/PPP1R12A/RPS6KB1/ARAF/RAF1/GAB1/PPP1R12B/TFAP4/PLCE1/FZD6/PRKCB/SOS2/WNT11/PIK3CD/PLCG2/SLC9A1/CASP3/PTCH1/AKT3/WNT3/SRC/HPSE/PPP1R12C/PIK3R2/DROSHA/ELK1/PLCG1/MTOR	4.66273762750691
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	44/3000	77/9376	1.78590476190476	TGFBR1/TGFBR2/VEGFA/GADD45B/CDK6/CDKN1A/PIK3R1/SMAD3/STAT3/CDK4/KRAS/POLK/SMAD4/AKT2/MAPK1/TGFB3/PLD1/RALGDS/NFKB1/CCND1/PIK3CA/RAC2/TGFB2/DDB2/BCL2L1/GADD45G/RPS6KB1/ARAF/RAF1/IKBKG/IKBKB/MAPK8/RELA/RB1/BAX/PIK3CD/ARHGEF6/AKT3/MAPK10/PIK3R2/MTOR/PLD2/E2F1/CHUK	4.74973380176598
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	58/3000	110/9376	1.64790303030303	PITX2/EMP3/TGFBR1/TGFBR2/BMP5/DCN/FBN1/BAMBI/GDF6/ACVR2A/FMOD/CREBBP/FST/TFRC/SMAD5/HAMP/THBS1/BMPR2/SMURF2/SMAD3/SMAD6/NCOR1/SKIL/ROCK1/SKI/SMAD7/PPP2CB/BMPR1A/SMAD4/MAPK1/TGFB3/ZFYVE16/THSD4/LRRC32/ACVR1B/TGFB2/BMP4/MYC/ACVR1/SP1/BMP6/ID2/LEFTY2/SIN3A/SMAD9/LEMD3/RPS6KB1/E2F4/LTBP1/NEO1/TGIF2/CDKN2B/TGIF1/EP300/HFE/TMEM53/LEFTY1/ZFYVE9	4.68848269298721
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	55/3000	103/9376	1.66886731391586	TNFRSF1A/TGFBR1/TGFBR2/IFNGR2/MAPK14/PIK3R1/GNAI1/GNAI2/JUN/FAS/PPP2CB/C1QB/AKT2/MAPK1/C1QA/TGFB3/PLCB1/NFKB1/SERPINE1/PIK3CA/C1QC/IFNGR1/GNA15/CFLAR/IL10/TLR2/TGFB2/NFKBIA/MAP2K4/TLR4/GNA14/PLCB2/PPP2R2D/IRAK4/IKBKG/IKBKB/MAPK8/KNG1/RELA/FOS/IRAK1/TICAM1/GNA11/TLR6/PIK3CD/FADD/TRAF6/AKT3/IL6/C3/MAPK10/CCL5/PIK3R2/CCL3/CHUK	4.68188311615597
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	42/3000	73/9376	1.79813698630137	HGF/EML4/FOXO3/GADD45B/CDK6/CDKN1A/PRKCA/RARB/PIK3R1/STAT3/CDK4/PDPK1/KRAS/POLK/RASSF5/AKT2/MAPK1/CCND1/PIK3CA/RXRB/STAT5A/SOS1/JAK3/DDB2/KIF5B/GADD45G/ARAF/RAF1/PRKCB/SOS2/STK4/RB1/BAX/STAT5B/PIK3CD/PLCG2/RASSF1/AKT3/RXRA/PIK3R2/PLCG1/E2F1	4.69569053882277
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	64/3000	125/9376	1.60017066666667	TNFRSF1A/CTSD/SGMS1/ASAH1/CERS2/MAPK14/PRKCA/PIK3R1/GNAI1/DEGS1/GNAI2/FCER1G/GNA13/ORMDL1/FYN/ROCK1/SMPD1/PDPK1/KRAS/PPP2CB/CERS6/TRADD/ROCK2/AKT2/MAPK1/PLCB1/PLD1/NFKB1/PIK3CA/BID/BCL2/RAC2/PPP2R5E/PTEN/SGMS2/SPHK1/SGPL1/PLCB2/RAF1/SPTLC2/ORMDL3/PPP2R2D/PPP2R3C/NOS3/PRKCB/MAPK8/KNG1/RELA/S1PR4/BAX/PPP2R5A/CERS4/S1PR3/S1PR5/PIK3CD/ADORA1/AKT3/NSMAF/PPP2R5B/SPTLC1/MAPK10/PIK3R2/SPHK2/PLD2	4.63348266825
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	40/3000	70/9376	1.78590476190476	HLA-B/HLA-A/LAMA2/HLA-DRA/SGCE/HLA-F/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DMB/HLA-C/HLA-DQA2/ITGB2/HLA-DQA1/ABL1/HLA-DRB1/HLA-DQB1/HLA-E/SGCA/SNTB1/CD86/SGCB/SGCD/FYN/SNTB2/ICAM1/EIF4G3/CCND1/BID/SNTA1/HLA-DOA/DMD/RAC2/ITGAL/CD40/EIF4G2/ABL2/DTNA/EIF4G1/CASP3	4.52698992029937
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	59/3000	115/9376	1.60343188405797	CREB3L1/ADCY3/MEF2A/ITPR1/CDKN1A/PRKCA/GNAI1/GNAI2/WNK1/GNA13/MAFB/ADCY9/FGFR1/CYP24A1/ARRB2/MMP16/PTH1R/VDR/PRKACA/MAPK1/ADCY7/PDE4A/MEF2D/CREB1/PLCB1/PLD1/LRP5/JUND/ATF2/AKAP13/RXRB/PRKACB/PDE4B/BCL2/HBEGF/ITPR2/LRP6/ATF6B/ARHGEF11/NR4A2/SP1/ARRB1/PLCB2/STK39/CREB3/ARAF/RAF1/PRKCB/ADCY6/FOS/MEF2C/GNA11/CREB5/RUNX2/SGK1/RXRA/ATF4/WNK3/PLD2	4.4660167037685
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	81/3000	170/9376	1.48912941176471	HGF/WNT2/TGFBR1/TGFBR2/FZD2/WNT2B/GSTT1/IGF2/WNT5B/GADD45B/CDK6/CDKN1A/PRKCA/FZD1/PIK3R1/SMAD3/FZD7/SMARCD3/APC/NFE2L2/CDK4/IGF1R/GSTM3/KRAS/POLK/SMAD4/AKT2/MAPK1/SHC2/TGFB3/SMARCC2/LRP5/CCND1/PIK3CA/SOS1/LRP6/MGST2/TGFB2/ARID1B/DDB2/DVL3/MYC/PTEN/BCL2L1/KEAP1/DVL2/FZD4/TCF7L1/GADD45G/RPS6KB1/PHF10/ARAF/PBRM1/RAF1/GAB1/SHC1/BRD7/FZD6/SMARCE1/ARID1A/PRKCB/SOS2/GSTO1/RB1/BAX/GSK3B/SMARCD2/WNT11/PIK3CD/PLCG2/TXNRD1/NQO1/GSTM2/AKT3/ARID2/WNT3/PIK3R2/ELK1/PLCG1/MTOR/E2F1	4.41453398825924
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	86/3000	184/9376	1.46075362318841	SEMA6D/EPHA3/SLIT3/SLIT2/CFL2/PLXNB2/WNT5B/RRAS/ENAH/EFNB2/RYK/ABL1/NRP1/PRKCA/DPYSL2/CAMK2D/PIK3R1/GNAI1/BMPR2/GNAI2/CXCR4/SMO/EPHA7/FYN/ROCK1/PLXNA2/PLXNA4/PDPK1/PLXNC1/KRAS/NFATC4/EFNA5/SEMA3C/NFATC3/ROCK2/MAPK1/TRPC1/LIMK1/SEMA6B/UNC5B/LRIG2/PIK3CA/EFNB1/NFATC2/PPP3CB/CAMK2A/RAC2/RGS3/ROBO1/SEMA4A/ARHGEF12/SSH1/PPP3CC/ROBO3/BOC/SEMA3A/ILK/ROBO2/CDK5/RAF1/EFNA2/SEMA5A/NEO1/PLXNA1/NCK1/GSK3B/PPP3R1/PIK3CD/PLCG2/NCK2/EFNB3/UNC5C/EPHB2/PTCH1/SEMA3G/PLXNA3/SRC/EPHB6/MYL9/EPHB3/TRPC6/PIK3R2/PLCG1/PLXNB1/PARD3/PARD6G	4.3295700837254
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	56/3000	109/9376	1.60567584097859	CD36/CREB3L1/TNFRSF1A/PPP1R3C/IRS1/MLXIP/PIK3R1/GFPT2/STAT3/PDPK1/SLC27A3/AKT2/SOCS3/RPS6KA3/CREB1/PTPN1/NFKB1/PIK3CA/NR1H3/CPT1A/TRIB3/PTEN/G6PC3/PRKAA1/NFKBIA/CREB3/RPS6KB1/SLC27A1/PRKCD/NOS3/PRKCB/OGT/IKBKB/MAPK8/RELA/PPARA/PRKAG2/CREB5/GSK3B/PIK3CD/SREBF1/PPP1R3E/ACACB/PRKAG1/AKT3/IL6/MAPK10/PPARGC1B/PPP1R3D/PRKAB1/CRTC2/PIK3R2/PYGB/TBC1D4/MTOR/GFPT1	4.36270683056464
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	93/3000	203/9376	1.43180295566502	SPP1/HGF/CCND2/PDGFRA/LAMA2/LAMB2/VTN/COL6A1/COL6A2/COL1A2/COL1A1/EMP2/LAMC3/ITGA1/ARHGAP5/VEGFA/CCND3/CAPN2/PDGFC/PDGFA/PRKCA/VEGFC/PIK3R1/THBS1/PDGFRB/ARHGAP35/EMP1/JUN/ITGB5/FYN/ROCK1/BCAR1/FN1/IGF1R/PDPK1/PARVG/ITGA11/RAP1A/ROCK2/AKT2/MAPK1/SHC2/CCND1/PIK3CA/BIRC3/BCL2/FLNA/SOS1/BIRC2/COL4A5/ITGA4/RAC2/TNXB/PTEN/TLN2/CAV2/VEGFB/XIAP/THBS3/VAV1/PPP1R12A/LAMB1/ILK/COL6A6/RAF1/PPP1R12B/SHC1/PARVB/LAMC1/PRKCB/SOS2/MAPK8/COL9A2/CRK/PIP5K1C/GSK3B/COL9A3/RAP1B/MYLK/PIK3CD/ITGB7/AKT3/DOCK1/SRC/MYLK3/PIP5K1A/MAPK10/MYL9/PPP1R12C/LAMB3/PIK3R2/ELK1/TLN1	4.26628676925214
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	89/3000	193/9376	1.44121588946459	CXCL14/ADCY3/FOXO3/CXCL16/LYN/PIK3R1/GNAI1/GNAI2/CXCR4/GNG11/ADCY9/STAT3/ARRB2/ROCK1/GNB4/CCL18/BCAR1/KRAS/RAP1A/ROCK2/PRKACA/AKT2/MAPK1/SHC2/ADCY7/FGR/PLCB1/DOCK2/NFKB1/PIK3CA/PRKACB/HCK/SOS1/JAK3/JAK2/WAS/PIK3R5/RAC2/CXCL3/CXCL9/ARRB1/NFKBIA/CCL7/PLCB2/VAV1/CXCL2/ELMO1/RAF1/SHC1/PRKCD/CXCL10/GSK3A/PRKCB/IKBKG/IKBKB/ADCY6/CCL23/SOS2/RELA/CRK/XCL1/CCR5/GNB2/PREX1/GRK5/GNGT2/GSK3B/RAP1B/STAT5B/PIK3CD/PLCG2/CCL28/CCL20/PF4/AKT3/GNB3/SRC/CCL26/CCL5/PIK3R2/PLCG1/CXCL1/CCR10/CCL3/PARD3/GNG12/GRK4/GNGT1/CHUK	4.24824561653349
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	51/3000	98/9376	1.62644897959184	CALM2/ITPR1/PRKCA/PIK3R1/CDIPT/PLCB1/PIK3CA/ITPR2/PIP4K2A/SACM1L/PLCD3/INPP1/PIKFYVE/PTEN/IP6K1/MTMR6/PI4KB/PIK3C3/PLCB2/PI4K2A/DGKH/PLCE1/MTMR2/MTMR3/MTMR14/PRKCB/INPP5D/INPP5A/IP6K3/PIP5K1C/ITPK1/DGKQ/PIP4K2B/IP6K2/INPPL1/PIK3CD/PLCG2/ITPKA/IPMK/ITPKC/DGKD/ITPKB/DGKE/PIP5K1A/OCRL/PPIP5K2/PIK3R2/PLCG1/PI4KA/INPP5E/DGKA	4.27605882687631
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	64/3000	130/9376	1.53862564102564	CREB3L1/TGFBR1/TGFBR2/COL1A2/COL3A1/COL1A1/ADCY3/VEGFA/MAPK14/PRKCA/VEGFC/PIK3R1/GNAI1/GNAI2/MMP9/GNG11/ADCY9/JUN/ARRB2/GNB4/KRAS/EDNRB/PRKACA/AKT2/MAPK1/SHC2/ADCY7/CREB1/PLCB1/NFKB1/ATF2/PIK3CA/PRKACB/SOS1/GNA15/COL4A5/ATF6B/ARRB1/NFKBIA/MAP2K4/VEGFB/PLCB2/CREB3/RAF1/SHC1/NOS3/ADCY6/SOS2/MAPK8/RELA/FOS/MAP2K7/GNB2/CREB5/GNGT2/PIK3CD/AKT3/GNB3/SRC/MAPK10/PIK3R2/ATF4/GNG12/GNGT1	4.24183593486659
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	81/3000	174/9376	1.45489655172414	MAN1A1/BAG2/MBTPS1/AMFR/RRBP1/CAPN2/MAN1C1/SEC62/HSPA1A/HERPUD1/CRYAB/SEC31A/SEC63/DNAJC1/EDEM3/TRAM1/NFE2L2/SEL1L/UBXN6/STUB1/ERLEC1/MAN1B1/HSPA1B/BCAP29/UBXN4/SEC24D/BCL2/SIL1/OS9/PPP1R15A/UGGT2/SEC23A/ATF6B/DNAJB12/CKAP4/DERL2/HSPA6/SEC24B/ATF6/HSP90B1/SYVN1/DNAJB2/MBTPS2/UBQLN2/DNAJB1/DERL1/RPN1/NPLOC4/RNF5/DNAJC5B/SEC13/MAPK8/DDIT3/SAR1B/UBE2D2/EIF2AK3/MAP2K7/BAX/UBQLN4/TXNDC5/UBE4B/NGLY1/KRTCAP2/UBE2J2/FBXO6/SEC61A1/UBE2G2/DNAJC5/YOD1/HSPBP1/MAPK10/SSR1/SEC61A2/ATXN3/SEC24C/RNF185/ERN1/SEC24A/UBXN2A/ATF4/TRAM1L1	4.15449524063613
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	41/3000	75/9376	1.70851555555556	CCND2/SESN3/IGFBP3/CCND3/GADD45B/CDK6/TSC2/CDKN1A/CD82/THBS1/CCNG2/CDK4/FAS/ATM/RCHY1/SESN1/CCND1/SERPINE1/ZMAT3/BID/BCL2/ZNF385A/PPM1D/CHEK2/DDB2/PTEN/BCL2L1/GORAB/BBC3/GADD45G/MDM4/STEAP3/RRM2B/BAX/ATR/SIAH1/TNFRSF10B/CASP3/APAF1/TNFRSF10A/SESN2	4.22558955695573
Human Diseases	Infectious disease: viral	hsa05162	Measles	66/3000	136/9376	1.51670588235294	CCND2/CCND3/HSPA1A/CDK6/PIK3R1/JUN/STAT3/CDK4/FAS/RAB9A/TRADD/AKT2/RCHY1/IFNAR1/MSN/TAB2/NFKB1/CCND1/PIK3CA/BID/HSPA1B/STAT5A/BCL2/JAK3/TLR2/HSPA6/IFIH1/BCL2L1/NFKBIA/CD46/ADAR/CDKN1B/TLR4/TLR7/IL2RG/CSNK2A1/BBC3/MX2/MAP3K7/IRAK4/IKBKG/CSNK2A2/IKBKB/MAPK8/RELA/FOS/IRAK1/BAX/CSNK2B/GSK3B/TNFAIP3/IKBKE/STAT5B/PIK3CD/FADD/TRAF6/CASP3/APAF1/AKT3/IL6/TYK2/OAS2/MAPK10/PIK3R2/FCGR2B/CHUK	4.1634081274606
Organismal Systems	Immune system	hsa04611	Platelet activation	62/3000	126/9376	1.53786243386243	COL1A2/COL3A1/COL1A1/ADCY3/ITPR1/MAPK14/PRKG1/LYN/PIK3R1/GNAI1/GNAI2/FCER1G/FERMT3/GNA13/ORAI1/ADCY9/ARHGAP35/FYN/ROCK1/PTGIR/GUCY1A2/P2RY1/RAP1A/ROCK2/PRKACA/AKT2/MAPK1/ADCY7/FCGR2A/PLCB1/SYK/PIK3CA/BTK/PRKACB/TBXAS1/LCP2/ITPR2/TBXA2R/PIK3R5/PTGS1/TLN2/ARHGEF12/PRKCI/PLCB2/PPP1R12A/APBB1IP/NOS3/ADCY6/PLA2G4A/RAP1B/MYLK/PIK3CD/PLCG2/P2RX1/ADAMTS13/AKT3/SNAP23/PLA2G4C/SRC/MYLK3/PIK3R2/TLN1	4.16924801149731
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	16/3000	21/9376	2.38120634920635	CSGALNACT1/DSEL/DSE/CSGALNACT2/B3GAT3/CHST14/CHSY3/UST/CHPF2/CHST12/B3GALT6/XYLT1/CHST3/CHST13/CHST15/XYLT2	4.34628728045437
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	73/3000	154/9376	1.48148917748918	CALM2/ADCY3/ITPR1/CDKN1A/PRKCA/CAMK2D/GNAI1/GNAI2/ADCY9/RGS2/JUN/CACNA2D1/ROCK1/KRAS/NFATC4/GUCY1A2/NFATC3/ROCK2/PRKACA/MAP2K5/MAPK1/ADCY7/PLCB1/CCND1/PRKACB/EEF2K/ITPR2/NFATC2/PPP3CB/CAMK2A/PIK3R5/MAPK7/CAMK1D/CAMK1/PRKAA1/NPR2/PPP3CC/CACNB4/PLCB2/PPP1R12A/KCNJ12/RAF1/PPP1R12B/CACNA2D4/KCNJ5/CAMKK2/RYR2/NOS3/PRKCB/PTGS2/ADCY6/PLA2G4A/FOS/MEF2C/PRKAG2/CD38/MYLK/PPP3R1/KCNJ2/PRKAG1/CACNB2/PLA2G4C/CACNA1C/SRC/NFATC1/MYLK3/MYL9/PPP1R12C/CACNB3/RYR1/PRKAB1/ELK1/CACNB1	4.13243891575931
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	40/3000	73/9376	1.71251141552511	BST2/SERINC3/CREBBP/MAP1B/SAMHD1/MDFIC/MLLT3/CXCR4/FEZ1/CD4/ELL2/MAP1S/APOBEC3C/AFF4/MAP1A/CCNT2/CPSF7/SERINC5/RANBP2/NELFE/VPS4A/APOBEC3G/PDCD6IP/BICD2/MX2/PIN1/CDK9/KAT2B/CCR5/SUPT4H1/NELFB/CHMP6/VPS4B/HGS/EP300/APOBEC3F/NUP153/APOBEC3A/NELFA/BICD1	4.19192841593383
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	96/3000	214/9376	1.40201869158878	HLA-B/HLA-A/BST2/TNFRSF1A/HLA-F/CALM2/CFL2/B2M/HLA-C/ITPR1/MAPK14/SAMHD1/PRKCA/HLA-E/PIK3R1/GNAI1/GNAI2/CXCR4/GNG11/CD4/JUN/GNB4/FAS/KRAS/NFATC4/NFATC3/TRADD/ATM/AP1S2/AKT2/MAPK1/TAPBP/APOBEC3C/LIMK1/TAB2/NFKB1/PIK3CA/BID/TNFRSF1B/BCL2/ITPR2/RIPK1/CUL5/NFATC2/PPP3CB/RAC2/TAPBPL/TLR2/BCL2L1/FBXW11/NFKBIA/PPP3CC/TLR4/APOBEC3G/RPS6KB1/RAF1/PRKCB/MAP3K7/IRAK4/IKBKG/AP1G1/IKBKB/MAPK8/RELA/CRK/FOS/CCR5/IRAK1/AP1M1/MAP2K7/GNB2/BAX/BTRC/ATR/GNA11/GNGT2/PPP3R1/PIK3CD/PLCG2/FADD/TRAF6/CASP3/AKT3/GNB3/APOBEC3F/NFATC1/MAPK10/TRAF5/APOBEC3A/PIK3R2/PLCG1/MTOR/AP1G2/GNG12/GNGT1/CHUK	4.08065707948494
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	42/3000	78/9376	1.68287179487179	CDIPT/MINPP1/PLCB1/PIK3CA/PIP4K2A/SACM1L/PLCD3/INPP1/PIKFYVE/INPP5K/PTEN/IP6K1/MTMR6/PI4KB/PIK3C3/PLCB2/PI4K2A/PLCE1/MTMR2/MTMR3/MTMR14/INPP5D/INPP5A/IP6K3/PIP5K1C/ITPK1/FIG4/PIP4K2B/IP6K2/INPPL1/PIK3CD/PLCG2/ITPKA/IPMK/ITPKC/ITPKB/PIP5K1A/OCRL/PPIP5K2/PLCG1/PI4KA/INPP5E	4.15397441109857
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	47/3000	90/9376	1.63211851851852	EML4/IFNGR2/MAPK14/PIK3R1/CD4/JUN/STAT3/KRAS/NFATC3/AKT2/MAPK1/NFKB1/PIK3CA/IFNGR1/NFKBIE/JAK2/NFATC2/PPP3CB/MAP3K3/TLR2/PTEN/NFKBIA/PTPN6/PPP3CC/TLR4/CSNK2A1/HIF1A/RPS6KB1/RAF1/LAT/IKBKG/CSNK2A2/IKBKB/BATF/RELA/FOS/TICAM1/CSNK2B/PPP3R1/PIK3CD/TRAF6/AKT3/NFATC1/PIK3R2/PLCG1/MTOR/CHUK	4.13311548275728
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	82/3000	178/9376	1.43976029962547	CCND2/WNT2/RSPO2/RSPO3/SERPINF1/FRZB/MCC/FZD2/BAMBI/PRICKLE1/WNT2B/WNT5B/CREBBP/CCND3/RYK/PRKCA/CAMK2D/FZD1/SMAD3/FZD7/APC/JUN/TBL1XR1/DAAM1/LZTS2/NFATC4/SFRP2/NFATC3/SMAD4/ROCK2/PRKACA/PLCB1/LRP5/CCND1/ROR2/PRKACB/NFATC2/PPP3CB/LRP6/CAMK2A/RAC2/CBY1/PSEN1/MMP7/DVL3/MYC/DVL2/FBXW11/FZD4/PPP3CC/CSNK2A1/PLCB2/TCF7L1/VANGL1/FZD6/PRKCB/MAP3K7/SIRT1/CSNK2A2/MAPK8/PRICKLE2/ZNRF3/DKK2/BTRC/CSNK2B/SENP2/TLE4/SIAH1/GSK3B/NKD2/WNT11/PPP3R1/CTBP2/EP300/ROR1/WNT3/CHD8/NFATC1/CCAR2/MAPK10/DAAM2/INVS	4.06304310463047
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	45/3000	86/9376	1.6353488372093	ABL1/CDKN1A/PRKCA/CAMK2D/PIK3R1/EIF4EBP1/JUN/KRAS/AKT2/MAPK1/SHC2/PIK3CA/STAT5A/SOS1/HBEGF/CAMK2A/EREG/MYC/MAP2K4/CDKN1B/RPS6KB1/ARAF/RAF1/GAB1/SHC1/NRG2/PRKCB/SOS2/MAPK8/CRK/MAP2K7/NCK1/GSK3B/ABL2/STAT5B/PIK3CD/PLCG2/NCK2/AKT3/SRC/MAPK10/PIK3R2/ELK1/PLCG1/MTOR	4.05999706310912
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	85/3000	187/9376	1.42060606060606	TXNIP/GABARAPL2/ANTXR2/NLRP1/IFI16/CASP1/ANTXR1/IL18/ITPR1/MAPK14/PKN1/GPSM3/AIM2/CTSB/CYBB/GABARAP/GABARAPL1/JUN/NEK7/TRPV2/MAPK1/IFNAR1/PLCB1/TAB2/NFKB1/BIRC3/BCL2/ITPR2/BIRC2/RIPK1/P2RX7/PKN2/TRIP6/GBP4/CXCL3/TRPM7/GBP5/NAMPT/GBP3/SHARPIN/BCL2L1/PYCARD/CARD16/NFKBIA/XIAP/TLR4/PSTPIP1/RBCK1/PLCB2/CXCL2/RNASEL/CARD9/TP53BP1/CARD6/PRKCD/NLRX1/MAP3K7/IRAK4/IKBKG/MAP1LC3B/IKBKB/MAPK8/RELA/NAIP/GBP1/MFN2/TICAM1/TNFAIP3/RIPK3/IKBKE/NOD1/FADD/NLRP3/TRAF6/IL6/TYK2/OAS2/MAPK10/TRAF5/GBP2/CCL5/CYBA/CXCL1/TAB3/CHUK	3.98505495773814
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	38/3000	70/9376	1.69660952380952	CD36/TNFRSF1A/IRS1/STAT3/ACSL3/APPL1/TRADD/AKT2/SOCS3/STK11/NFKB1/TNFRSF1B/RXRB/CPT1A/NFKBIE/JAK2/G6PC3/PRKAA1/NFKBIA/ADIPOR1/ACSL1/CAMKK2/IKBKG/IKBKB/POMC/MAPK8/RELA/PPARA/PRKAG2/ACACB/PRKAG1/AKT3/MAPK10/RXRA/PRKAB1/MTOR/LEPR/CHUK	4.01262906847282
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	45/3000	87/9376	1.61655172413793	TGFBR1/TGFBR2/GADD45B/CDKN1A/PIK3R1/SMAD3/APC/JUN/KRAS/APPL1/POLK/SMAD4/AKT2/MAPK1/TGFB3/RALGDS/CCND1/PIK3CA/BCL2/SOS1/RAC2/EREG/TGFB2/DDB2/MYC/BCL2L11/TCF7L1/BBC3/GADD45G/RPS6KB1/ARAF/RAF1/MSH6/MSH3/SOS2/MAPK8/FOS/BAX/GSK3B/PIK3CD/CASP3/AKT3/MAPK10/PIK3R2/MTOR	3.96293339122274
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	79/3000	173/9376	1.4271753371869	TNFRSF1A/HLA-DRA/HLA-DPA1/HLA-DPB1/CASP1/HLA-DMA/HLA-DMB/CREBBP/CCND3/IL18/HLA-DQA2/IFNGR2/HLA-DQA1/HLA-DRB1/CDK6/HLA-DQB1/PRKCA/PIK3R1/CDK4/FAS/ICAM1/TRADD/AKT2/MAPK1/IFNAR1/SOCS3/NFKB1/PIK3CA/BID/HLA-DOA/IFNGR1/KPNA5/JAK2/PML/CALCOCO2/IFIH1/PYCARD/HNRNPUL1/NFKBIA/CIITA/ADAR/TLR4/TLR7/RNASEL/RAF1/DNAJB1/CXCL10/MX2/NLRX1/TLR3/PRKCB/IRAK4/IKBKG/IKBKB/RAB11B/RELA/NXT1/BAX/TICAM1/IKBKE/RAE1/PIK3CD/FADD/NLRP3/EP300/TNFRSF10B/CASP3/APAF1/AKT3/TNFRSF10A/IL6/TYK2/OAS2/NXF1/NUP98/CCL5/PIK3R2/KPNA1/CHUK	3.88988375259485
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	38/3000	71/9376	1.67271361502347	PRLR/CCND2/CISH/SOCS1/FOXO3/MAPK14/GCK/PIK3R1/STAT3/KRAS/AKT2/MAPK1/SHC2/SOCS3/NFKB1/CCND1/PIK3CA/SOCS2/STAT5A/SOS1/SOCS5/JAK2/RAF1/SHC1/SOS2/MAPK8/RELA/FOS/GSK3B/SOCS6/STAT5B/PIK3CD/SOCS4/AKT3/SRC/MAPK10/GALT/PIK3R2	3.90277320328673
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	38/3000	71/9376	1.67271361502347	ATP6V0D1/MAPK14/LYN/ATP6V1G1/JUN/ADAM10/ATP6V1C1/NFKB1/TCIRG1/ATP6AP1/ATP6V0A1/HBEGF/TJP1/CXCL3/ATP6V0B/NFKBIA/MAP2K4/ATP6V1B2/ATP6V1D/JAM3/CXCL2/CSK/IKBKG/IKBKB/MAPK8/RELA/ATP6V1H/NOD1/PLCG2/CASP3/ATP6V0A2/SRC/MAPK10/CCL5/PLCG1/CXCL1/ATP6V0E1/CHUK	3.90277320328673
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	65/3000	138/9376	1.47207729468599	CALM2/SOCS1/FBP1/RHOQ/PPP1R3C/IRS1/TRIP10/TSC2/GCK/PIK3R1/EIF4EBP1/PDE3B/PDPK1/KRAS/PRKAR1A/PRKACA/AKT2/MAPK1/SHC2/SOCS3/PTPN1/PIK3CA/EXOC7/SOCS2/FLOT1/PRKACB/SOS1/HK3/G6PC3/PRKAA1/PHKB/PRKCI/RPS6KB1/ARAF/RAF1/SHC1/SORBS1/RHEB/PRKAR1B/INPP5A/LIPE/PRKAR2A/IKBKB/SOS2/MAPK8/CRK/TSC1/PRKAG2/GSK3B/INPPL1/PIK3CD/SREBF1/PPP1R3E/ACACB/PRKAG1/SOCS4/AKT3/PRKAR2B/MAPK10/PPP1R3D/PRKAB1/PIK3R2/ELK1/PYGB/MTOR	3.83209077773817
Human Diseases	Cancer: specific types	hsa05214	Glioma	40/3000	76/9376	1.64491228070175	PDGFRA/CALM2/GADD45B/CDK6/PDGFA/CDKN1A/PRKCA/CAMK2D/PIK3R1/PDGFRB/CDK4/IGF1R/KRAS/POLK/AKT2/MAPK1/SHC2/CCND1/PIK3CA/SOS1/CAMK2A/CAMK1D/CAMK1/DDB2/PTEN/GADD45G/ARAF/RAF1/SHC1/PRKCB/SOS2/RB1/BAX/PIK3CD/PLCG2/AKT3/PIK3R2/PLCG1/MTOR/E2F1	3.87202435426157
NA	NA	hsa04518	Integrin signaling	71/3000	154/9376	1.44090043290043	SPP1/HGF/CCND2/PDGFRA/VCAM1/LAMA2/LAMB2/VTN/COL6A1/COL6A2/COL1A2/COL1A1/FBN1/LAMC3/ITGA1/VEGFA/CCND3/PDGFC/ITGB2/ICAM4/PDGFA/VEGFC/PIK3R1/THBS1/FERMT3/PDGFRB/ITGB5/FREM1/FN1/IGF1R/PARVG/ICAM1/ITGAX/ITGA11/AKT2/CCND1/PIK3CA/ITGAM/FLNA/COL4A5/ITGA4/RAC2/ITGAL/TNXB/TLN2/VEGFB/THBS3/LAMB1/ILK/COL6A6/LIMS2/PARVB/LAMC1/ICAM2/COL9A2/GSK3B/COL9A3/PIK3CD/FERMT2/NCK2/ARHGEF6/ITGB7/AKT3/SRC/C3/LAMB3/NPNT/PIK3R2/TLN1/MTOR/LIMS1	3.78408112181053
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	67/3000	144/9376	1.45414814814815	IL6ST/WNT2/KLF4/FZD2/LIFR/ACVR2A/WNT2B/ZFHX3/WNT5B/PCGF5/MAPK14/SMAD5/FZD1/PIK3R1/BMPR2/SMAD3/FZD7/FGFR2/FGF2/KAT6A/FGFR1/APC/STAT3/SKIL/IGF1R/KRAS/BMPR1A/MEIS1/SMAD4/AKT2/MAPK1/FGFR4/PIK3CA/JAK3/JAK2/ACVR1B/BMP4/DVL3/MYC/DVL2/ACVR1/FZD4/PCGF2/ID2/LEFTY2/RIF1/SMAD9/RAF1/FGFR3/FZD6/REST/GSK3B/SMARCAD1/WNT11/HAND1/PIK3CD/SETDB1/TCF3/AKT3/WNT3/PCGF3/JARID2/BMI1/LEFTY1/PIK3R2/PCGF1/LIF	3.76706407363523
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	71/3000	155/9376	1.43160430107527	WNT2/CREB3L1/FZD2/HSD3B2/WNT2B/AHR/ADCY3/WNT5B/KMT2A/ITPR1/CDK6/CDKN1A/CAMK2D/FZD1/GNAI1/GNAI2/FZD7/ORAI1/ADCY9/APC/CDK4/AIP/RAP1A/PRKACA/MAPK1/ADCY7/CREB1/PLCB1/CCND1/ATF2/KCNK3/MRAP/PRKACB/ITPR2/NCEH1/PBX1/CAMK2A/USP8/ATF6B/DVL3/DVL2/FZD4/SP1/CDKN1B/PLCB2/TCF7L1/CREB3/FZD6/ADCY6/POMC/RB1/ARMC5/GNA11/CREB5/SCARB1/WDR5B/GSK3B/RAP1B/ASH2L/CDKN2B/WNT11/PDE8A/RASD1/RBBP5/WNT3/CACNA1C/KMT2D/PDE8B/CACNA1G/ATF4/E2F1	3.71650493101246
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	88/3000	200/9376	1.37514666666667	TNFRSF1A/CASP1/IL18/ABL1/MAPK14/IL1R1/LPAR1/GNA13/JUN/WASL/MYH10/FYN/ROCK1/ARHGEF2/WIPF1/FAS/NCKAP1L/CLDN11/TRADD/ROCK2/MAPK1/WASF2/FCGR2A/MYO1D/TAB2/NFKB1/TUBB2A/SEC24D/MYO1C/CYTH1/ARF1/RIPK1/MYO5A/TJP1/ARHGEF11/TUBA1A/MYO1F/PYCARD/ARHGEF12/NFKBIA/CLDN23/PTPN6/SEC24B/TLR4/CASP7/CYTH4/ABI1/TLR5/NCKAP1/CYTH2/MAP3K7/IRAK4/IKBKG/LPAR5/IKBKB/MAPK8/RELA/MYO1G/FOS/NAIP/WIPF2/IRAK1/BAIAP2/NCK1/BAX/CYTH3/WIPF3/TUBA3D/FADD/NCK2/NLRP3/TRAF6/CLDN15/TNFRSF10B/TUBA4A/CASP3/RAB1A/SRC/TNFRSF10A/IL6/CLDN12/MAPK10/SEC24C/SEC24A/MYO10/TAB3/CHUK/CLDN1	3.67842155360163
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	58/3000	122/9376	1.48581420765027	CD36/CREB3L1/FBP1/IRS1/FOXO3/TSC2/PIK3R1/EIF4EBP1/IGF1R/PDPK1/PPP2CB/PFKM/AKT2/CREB1/STK11/CCND1/PIK3CA/EEF2K/CPT1A/RAB14/SCD5/PPP2R5E/PFKFB3/G6PC3/PRKAA1/CAB39/ADIPOR1/ULK1/CREB3/RPS6KB1/MLYCD/TBC1D1/RHEB/CAMKK2/PPP2R2D/PPP2R3C/MAP3K7/LIPE/SIRT1/RAB11B/TSC1/PRKAG2/PPP2R5A/CREB5/RAB2A/PIK3CD/SREBF1/AKT1S1/ACACB/PRKAG1/AKT3/PPP2R5B/PFKFB2/PRKAB1/CRTC2/PIK3R2/MTOR/LEPR	3.70473792103921
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	14/3000	19/9376	2.30287719298246	NAGLU/HEXA/HYAL2/HEXB/GUSB/GALNS/GNS/IDS/GLB1/ARSB/HGSNAT/SGSH/IDUA/HPSE	3.89927691766047
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	31/3000	56/9376	1.73009523809524	CASP1/IL18/ITGB2/HSPA1A/NFKB1/HSPA1B/ITGAM/ARF1/CXCL3/TLR2/HSPA6/PYCARD/NFKBIA/NFKB2/TLR4/CLK4/CASP7/CXCL2/CLK1/TLR5/SAR1B/RELA/NAIP/CD14/CASP3/APAF1/RAB1A/IL6/HBS1L/C3/CXCL1	3.75870017814196
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	88/3000	201/9376	1.36830514096186	MAF/CCND2/NUPR1/TGFBR2/IGFBP3/RUNX1T1/KLF3/KMT2A/GADD45B/JMJD1C/PDGFA/CDKN1A/SPI1/PLAT/MLLT3/HOXA10/CD86/MMP9/PBX3/NCOR1/FCGR1A/IGF1R/RARA/HOXA11/POLK/MEIS1/ATM/NFKB1/LDB1/FUS/PLAU/RXRB/BIRC3/LYL1/ITGAM/BIRC2/PML/NR4A3/PBX1/MAX/CDK14/ELK4/CCNT2/CEBPB/ETV6/DDB2/MYC/BCL2L1/BCL2A1/SP1/PRCC/BMP2K/CDKN1B/ID2/MITF/HOXA9/TFE3/SIN3A/GADD45G/CD40/RUNX1/CDK9/HHEX/DDIT3/SLC45A3/RELA/FLI1/CD14/MEF2C/TRAF1/PTCRA/BAX/ERG/EWSR1/ZEB1/RUNX2/TCF3/BCL6/ITGB7/SUPT3H/REL/IL6/SS18L1/ZBTB17/BMI1/RXRA/PAX8/MLF1	3.62055279353118
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	47/3000	95/9376	1.54621754385965	HLA-DRA/CSF1/HLA-DPA1/HLA-DPB1/TNFSF13B/HLA-DMA/VEGFA/HLA-DMB/ATP6V0D1/IL18/HLA-DQA2/ITGB2/HLA-DQA1/HLA-DRB1/ACP5/HLA-DQB1/CD86/ATP6V1G1/JUN/ICAM1/ATP6V1C1/TGFB3/TEK/TCIRG1/HLA-DOA/ATP6AP1/ATP6V0A1/ANGPT1/CXCL3/ATP6V0B/TLR2/TGFB2/ITGAL/TLR4/ATP6V1B2/ATP6V1D/IL11/CXCL2/FOS/ATP6V1H/CCL20/ATP6V0A2/IL6/CCL5/CXCL1/CCL3/ATP6V0E1	3.67030514688123
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	48/3000	98/9376	1.53077551020408	MARCKS/BIN1/CFL2/FCGR3A/GSN/LYN/PRKCA/PIK3R1/FCGR1A/ASAP1/PTPRC/AKT2/MAPK1/WASF2/FCGR2A/LIMK1/PLD1/SYK/PIK3CA/HCK/WAS/RAC2/SPHK1/VAV1/RPS6KB1/RAF1/PRKCD/LAT/SCIN/PRKCB/INPP5D/ASAP2/PLA2G4A/CRK/PIP5K1C/INPPL1/PIK3CD/PLCG2/AKT3/DOCK1/PLA2G4C/PIP5K1A/PIK3R2/FCGR2B/PLCG1/MYO10/SPHK2/PLD2	3.62300423408259
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	75/3000	168/9376	1.3952380952381	PRLR/IL6ST/CCND2/PDGFRA/FHL1/EPOR/CISH/LIFR/IL6R/CNTFR/SOCS1/CREBBP/IL11RA/CCND3/IFNGR2/OSMR/PDGFA/CDKN1A/PIK3R1/PDGFRB/IL4R/STAT3/PIAS1/STAT6/CTF1/AKT2/OSM/IL10RB/IFNAR1/SOCS3/CCND1/PIK3CA/SOCS2/STAT5A/BCL2/SOS1/IFNGR1/SOCS5/JAK3/JAK2/IL10/PIAS2/MYC/CSH2/BCL2L1/CLCF1/PTPN6/IL2RG/CSH1/IL11/RAF1/IL13RA1/IL27RA/IL7R/STAM2/SOS2/GHR/STAM/PTPN2/PIAS3/SOCS6/STAT5B/PIK3CD/IL12RB1/EP300/SOCS4/AKT3/IL6/TYK2/PIAS4/TSLP/PIK3R2/MTOR/LIF/LEPR	3.54570740656776
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	20/3000	32/9376	1.95333333333333	TNFRSF1A/BID/BIRC3/BCL2/BIRC2/BCL2L1/BCL2L11/XIAP/CASP7/BBC3/BIRC6/MAPK8/HTRA2/BIRC7/BAX/FADD/CASP3/APAF1/MAPK10/DIABLO	3.70531781108263
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	64/3000	140/9376	1.42872380952381	SPP1/TGFBR1/CALM2/ADCY3/KLF2/RRAS/MEF2A/ITPR1/JAG1/PLAT/GNAI1/SMAD3/GNAI2/GNA13/GNG11/ADCY9/PDE3B/SLC8A1/GNB4/KRAS/SMAD4/PRKACA/AKT2/MAPK1/ADCY7/MRAS/MEF2D/PLCB1/CCND1/SERPINE1/PRKACB/MYL3/ITPR2/PIK3R5/PRKAA1/SPHK1/PIK3C3/PLCB2/RPS6KB1/RAF1/RYR2/NOS3/LIPE/MAP1LC3B/ADCY6/GNB2/MEF2C/PIK3R4/PRKAG2/HDAC4/GNGT2/MYLK/SLC9A1/PRKAG1/AKT3/GNB3/MYLK3/NRF1/RYR1/PRKAB1/MTOR/SPHK2/GNG12/GNGT1	3.50567595732854
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	67/3000	149/9376	1.40535123042506	PDGFRA/AGPAT4/ADCY3/RRAS/KITLG/PDGFC/AGPAT2/TSC2/PDGFA/PRKCA/LPAR1/PIK3R1/FCER1G/PDGFRB/GNA13/ADCY9/FYN/KRAS/AGPAT3/PTGFR/AKT2/MAPK1/SHC2/ADCY7/MRAS/PLCB1/PLD1/RALGDS/SYK/PIK3CA/SOS1/CYTH1/ARF1/PIK3R5/SPHK1/PLCB2/CYTH4/RAF1/GAB1/SHC1/DNM1/LPAR6/RHEB/DGKH/CYTH2/AGPAT1/LPAR5/ADCY6/PLA2G4A/SOS2/TSC1/PIP5K1C/CYTH3/DGKQ/PIK3CD/PLCG2/DGKD/AKT3/PLA2G4C/DGKE/PIP5K1A/PIK3R2/PLCG1/MTOR/SPHK2/PLD2/DGKA	3.42110560826843
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	65/3000	144/9376	1.41074074074074	TNFRSF1A/LY96/FOXO3/ALDH9A1/MAPK14/LPIN2/C3AR1/C5AR1/FAS/C2/TRADD/C1QB/AKT2/C1QA/ALDH3A2/IL17RC/TAB2/NFKB1/CCND1/CPT1A/C1QC/RIPK1/SCD5/CXCL3/ACADM/PRKAA1/NFKBIA/MAP2K4/TLR4/ADIPOR1/TCF7L1/CXCL2/LPIN1/MLYCD/CAMKK2/MAP3K7/IRAK4/IKBKG/SIRT1/IKBKB/MAPK8/RELA/PPARA/CD14/IRAK1/MAP2K7/PRKAG2/TICAM1/GSK3B/IKBKE/FADD/SREBF1/TRAF6/ACACB/PRKAG1/CASP3/AKT3/IL6/ALDH2/C3/MAPK10/PRKAB1/CXCL1/TAB3/CHUK	3.40700869161758
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	100/3000	238/9376	1.31316526610644	HGF/PDGFRA/CSF1/FGF7/CALM2/IGF2/VEGFA/RRAS/KITLG/PDGFC/ABL1/PDGFA/PRKCA/VEGFC/PIK3R1/FGFR2/PDGFRB/FGF2/GNG11/FGFR1/GNB4/IGF1R/KRAS/EFNA5/RAP1A/PRKACA/RASSF5/AKT2/MAPK1/SHC2/MRAS/TEK/FGFR4/PLD1/RALGDS/NFKB1/PIK3CA/RGL1/RASGRP3/PRKACB/RASA3/RAB5A/SOS1/ANGPT1/RAC2/PLA2G2A/BDNF/SHOC2/BCL2L1/RASAL2/RALGAPA1/VEGFB/RAF1/GAB1/SHC1/EFNA2/FGFR3/PLCE1/LAT/SYNGAP1/PRKCB/IKBKG/IKBKB/PLA2G4A/KSR1/SOS2/MAPK8/RALGAPB/RELA/STK4/RAB5C/GNB2/FLT3LG/RASA4/RALGAPA2/GNGT2/ABL2/RAP1B/PIK3CD/PLCG2/RASSF1/NF1/AKT3/GNB3/PLA2G4C/REL/ETS1/RASAL3/EXOC2/MAPK10/NTRK2/RIN1/PIK3R2/ELK1/PLCG1/PLD2/RAB5B/GNG12/GNGT1/CHUK	3.35666963954188
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	35/3000	68/9376	1.60862745098039	RUNX1T1/SPI1/PIK3R1/EIF4EBP1/STAT3/FCGR1A/RARA/KRAS/AKT2/MAPK1/NFKB1/CCND1/PIK3CA/STAT5A/ITGAM/SOS1/PML/MYC/BCL2A1/TCF7L1/RPS6KB1/ARAF/RAF1/RUNX1/IKBKG/IKBKB/SOS2/RELA/CD14/STAT5B/PIK3CD/AKT3/PIK3R2/MTOR/CHUK	3.45501483841877
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	20/3000	33/9376	1.89414141414141	VAMP5/STX4/STX2/STX11/VAMP2/GOSR1/STX18/VAMP4/STX7/STX5/VAMP7/STX16/STX17/USE1/STX1A/BET1L/BET1/STX6/SNAP23/VAMP1	3.52932877942928
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	27/3000	49/9376	1.72212244897959	GALNT1/GXYLT2/GALNT10/RFNG/GALNT12/POFUT2/GALNT7/GALNT11/LFNG/COLGALT1/PLOD3/XXYLT1/MFNG/C1GALT1/ST6GAL2/B4GALT2/OGT/B4GALT3/POMT2/ST3GAL3/POFUT1/FUT10/ST6GAL1/FUT11/POGLUT1/GALNT18/GALNT5	3.47624205535481
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	50/3000	106/9376	1.47421383647799	PDGFRA/CREB3L1/CREBBP/PDGFC/PDGFA/CDKN1A/PLAT/PIK3R1/FGFR2/PDGFRB/MMP9/FGFR1/IGF1R/PDPK1/KRAS/AKT2/MAPK1/CREB1/NFKB1/CCND1/PLAU/PIK3CA/BCL2/SOS1/PTEN/NFKBIA/CDKN1B/HSP90B1/TCF7L1/CREB3/ARAF/RAF1/IKBKG/IKBKB/SOS2/RELA/RB1/CREB5/ERG/GSK3B/ZEB1/PIK3CD/SLC46A1/EP300/AKT3/PIK3R2/MTOR/ATF4/E2F1/CHUK	3.36790163293102
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	51/3000	109/9376	1.4623119266055	SPP1/LY96/MAPK14/PIK3R1/CD86/JUN/AKT2/MAPK1/IFNAR1/TAB2/NFKB1/PIK3CA/RIPK1/TLR1/TLR2/IRF5/CXCL9/NFKBIA/MAP2K4/TLR4/TLR7/MAP3K8/CD40/TLR5/CXCL10/TLR3/MAP3K7/IRAK4/IKBKG/IKBKB/TLR8/MAPK8/RELA/FOS/CD14/IRAK1/MAP2K7/TICAM1/TLR6/IKBKE/PIK3CD/FADD/TRAF6/AKT3/IL6/TYK2/MAPK10/CCL5/PIK3R2/CCL3/CHUK	3.3300509341673
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	47/3000	99/9376	1.48374410774411	ADCY3/NOTCH2/JAG1/MAPK14/CDKN1A/PIK3R1/MMP9/ADCY9/NCOR1/JUN/CDK4/IGF1R/KRAS/PRKACA/AKT2/MAPK1/SHC2/ADCY7/CCND1/PIK3CA/PRKACB/BCL2/SOS1/HBEGF/SP1/CDKN1B/RPS6KB1/ARAF/RAF1/SHC1/MED1/ADCY6/SOS2/MAPK8/RB1/FOS/BAX/DLL4/PIK3CD/AKT3/SRC/NOTCH1/GPER1/MAPK10/PIK3R2/MTOR/E2F1	3.31895694430604
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	31/3000	60/9376	1.61475555555556	VEGFA/MAPK14/PRKCA/PIK3R1/MAPKAPK3/KRAS/AKT2/MAPK1/SHC2/PIK3CA/NFATC2/PPP3CB/RAC2/SPHK1/PPP3CC/MAPKAPK2/RAF1/HSPB1/NOS3/PRKCB/PTGS2/PLA2G4A/PPP3R1/PIK3CD/PLCG2/AKT3/PLA2G4C/SRC/PIK3R2/PLCG1/SPHK2	3.27669077744511
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	38/3000	78/9376	1.52259829059829	CALM2/CFL2/CASP1/C1R/LY96/ITGB2/MAPK14/GNAI1/GNAI2/JUN/C1S/C2/C1QB/MAPK1/C1QA/IRF8/NFKB1/C1QC/ITGAM/IL10/SERPING1/PYCARD/TLR4/CASP7/IRAK4/MAPK8/RELA/FOS/CD14/IRAK1/TICAM1/NOD1/NLRP3/TRAF6/CASP3/IL6/C3/MAPK10	3.17901536237372
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	27/3000	51/9376	1.65458823529412	ADCY3/ATP6V0D1/PRKCA/ATP6V1G1/ADCY9/PRKACA/ATP6V1C1/TCIRG1/PRKACB/ATP6AP1/ATP6V0A1/ARF1/TJP1/ATP6V0B/KDELR3/ATP6V1B2/ATP6V1D/KDELR1/ATP6V1H/SLC12A2/PLCG2/SEC61A1/ATP6V0A2/KCNQ1/SEC61A2/PLCG1/ATP6V0E1	3.21514804126908
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	103/3000	253/9376	1.27236890645586	TNFRSF1A/CD44/CASP1/CAST/IL18/CAPN2/UBB/FOXO3/ITPR1/PFN2/MAPK14/IL1R1/PIK3R1/JUN/WASL/ROCK1/ARHGEF2/BCAR1/RRAGD/TRADD/ATM/ROCK2/MALT1/WIPI2/AKT2/MAPK1/WASF2/PLCB1/TAB2/NFKB1/PIK3CA/CAPNS1/BCL2/RRAGA/CYTH1/ITPR2/ARF1/RIPK1/PLCD3/HK3/RRAGB/CALCOCO2/SHARPIN/TIFA/BCL2L1/TLN2/FBXW11/PYCARD/NFKBIA/SQSTM1/PIK3C3/TLR4/RBCK1/RRAGC/PLCB2/CYTH4/ILK/RPS6KB1/ELMO1/PRKCD/PLCE1/TLR5/U2AF1L4/GSK3A/CYTH2/ATG14/MAP3K7/IKBKG/MAP1LC3B/IKBKB/MAPK8/RELA/CRK/TNIP1/NAIP/CD14/UBE2D2/PIK3R4/BAX/BTRC/CYTH3/ELMO2/GSK3B/NOD1/PIK3CD/PLCG2/NLRP3/TRAF6/AKT1S1/AKT3/DOCK1/SRC/C3/MAPK10/MYL9/TRAF5/CCL5/PIK3R2/PLCG1/TLN1/MTOR/TAB3/CHUK	3.01245842334001
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	88/3000	212/9376	1.29730817610063	HGF/PDGFRA/CSF1/FGF7/CALM2/ADCY3/VEGFA/RRAS/ENAH/KITLG/PDGFC/ITGB2/PFN2/MAPK14/PDGFA/PRKCA/LPAR1/VEGFC/PIK3R1/THBS1/GNAI1/GNAI2/FGFR2/PDGFRB/FGF2/DOCK4/ADCY9/FGFR1/BCAR1/IGF1R/KRAS/EFNA5/P2RY1/RAP1A/ADORA2B/RASSF5/AKT2/MAPK1/ADCY7/MRAS/TEK/PLCB1/FGFR4/RALGDS/PIK3CA/RASGRP3/LCP2/ITGAM/KRIT1/ANGPT1/RAC2/ARAP3/ITGAL/MAGI2/TLN2/PRKCI/VEGFB/EVL/PRKD2/PLCB2/RAPGEF2/VAV1/PRKD1/APBB1IP/RAF1/EFNA2/FPR1/FGFR3/PLCE1/LAT/PRKCB/LPAR5/ADCY6/MAGI3/CRK/SIPA1/RAP1B/PIK3CD/AKT3/SIPA1L2/SRC/FARP2/PIK3R2/PLCG1/TLN1/RGS14/PARD3/PARD6G	3.00333898990592
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	34/3000	69/9376	1.5400193236715	MAPK14/LYN/PRKCA/PIK3R1/FCER1G/ALOX5AP/FYN/ALOX5/PDPK1/KRAS/AKT2/MAPK1/SYK/PIK3CA/BTK/LCP2/SOS1/RAC2/MAP2K4/VAV1/RAF1/LAT/INPP5D/PLA2G4A/SOS2/MAPK8/MAP2K7/PIK3CD/PLCG2/AKT3/PLA2G4C/MAPK10/PIK3R2/PLCG1	3.08816929363446
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	71/3000	166/9376	1.33673895582329	ATP1B1/CREB3L1/ATP2B1/CALM2/ADCY3/GATA4/IRS1/ADRB3/MEF2A/ITPR1/PRKG1/ATP1A1/GTF2I/PDE3A/GNAI1/GNAI2/GNA13/ADCY9/RGS2/PDE3B/SLC8A1/ROCK1/NFATC4/EDNRB/GUCY1A2/NFATC3/ROCK2/AKT2/MAPK1/ADCY7/MEF2D/CREB1/PLCB1/KCNMA1/ATF2/ATP1A2/ITPR2/NFATC2/PPP3CB/PIK3R5/ATF6B/ADRA2A/NPR2/PPP3CC/PLCB2/PPP1R12A/CREB3/RAF1/NOS3/ADCY6/KNG1/MEF2C/ATP2A2/GNA11/ATP2B4/CREB5/MYLK/PPP3R1/ADORA1/AKT3/CACNA1C/NFATC1/MYLK3/MYL9/TRPC6/ATP1B3/ATF4/KCNJ8/PDE5A/ATP2A3/ADRB2	3.0025462178207
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	62/3000	142/9376	1.36458215962441	VCAM1/TNFRSF1A/SDC2/ACVR2A/CALM2/GSTT1/KLF2/VEGFA/MEF2A/NCF2/MAPK14/IL1R1/PDGFA/PLAT/PIK3R1/BMPR2/MMP9/JUN/NFE2L2/ARHGEF2/GSTM3/ICAM1/BMPR1A/MAP2K5/AKT2/DUSP1/NFKB1/PIK3CA/BCL2/MAPK7/RAC2/MGST2/BMP4/KEAP1/ACVR1/CAV2/PRKAA1/SQSTM1/MAP2K4/HSP90B1/NOS3/MAP3K7/IKBKG/IKBKB/MAPK8/GSTO1/SUMO3/RELA/FOS/MAP2K7/MEF2C/THBD/PIK3CD/NQO1/GSTM2/AKT3/SRC/MAPK10/PIAS4/PIK3R2/CYBA/CHUK	3.00273330933439
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	31/3000	62/9376	1.56266666666667	ADCY3/IRS1/FOXO3/HSPA1A/PIK3R1/CRYAB/ADCY9/CAT/IGF1R/KRAS/PRKACA/AKT2/ADCY7/PIK3CA/HSPA1B/PRKACB/HSPA6/PRKAA1/RPS6KB1/SIRT1/ADCY6/EIF4EBP2/PRKAG2/PIK3CD/AKT1S1/PRKAG1/AKT3/SOD2/PRKAB1/PIK3R2/MTOR	3.04895508630554
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	28/3000	55/9376	1.59107878787879	SGMS1/NEU1/ASAH1/CERS2/HEXA/DEGS1/HEXB/ACER3/SMPD1/GLA/CERS6/UGCG/CERK/GLB1/SGMS2/SPHK1/SGPL1/SPTLC2/PSAP/GALC/B4GALT6/ARSA/CERS4/KDSR/SAMD8/B4GALT5/SPTLC1/SPHK2	3.01555723789473
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	36/3000	75/9376	1.50016	GSTT1/CDKN1A/PIK3R1/ERCC1/GSTM3/PDPK1/FAS/ATM/AKT2/MAPK1/XPA/SLC31A1/TOP2B/PIK3CA/BID/BIRC3/BCL2/BIRC2/MGST2/BCL2L1/XIAP/REV3L/BBC3/ATP7A/MSH6/MSH3/GSTO1/BAX/PIK3CD/FADD/CASP3/GSTM2/APAF1/AKT3/POLH/PIK3R2	2.98295620503319
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	54/3000	122/9376	1.38334426229508	MAPK14/PIK3R1/CD4/JUN/FYN/CDK4/PDPK1/PTPRC/KRAS/PPP2CB/NFATC3/MALT1/AKT2/MAPK1/NFKB1/PIK3CA/LCP2/SOS1/NFKBIE/NFATC2/PPP3CB/IL10/PPP2R5E/NFKBIA/PTPN6/DLG1/PPP3CC/MAP3K8/VAV1/RAF1/LAT/PPP2R2D/PPP2R3C/MAP3K7/IKBKG/IKBKB/SOS2/MAPK8/RELA/FOS/MAP2K7/NCK1/PPP2R5A/GSK3B/PPP3R1/PIK3CD/NCK2/AKT3/NFATC1/PPP2R5B/MAPK10/PIK3R2/PLCG1/CHUK	2.92331925039079
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	47/3000	104/9376	1.41241025641026	PLD3/LPCAT2/AGPAT4/SGMS1/PLA2G15/AGPAT2/LPGAT1/LPIN2/CDIPT/AGPAT3/CHPT1/CEPT1/PLD1/MBOAT2/GPAT2/PLA2G2A/PGS1/SGMS2/CHAT/LPIN1/PTDSS1/DGKH/GNPAT/LPCAT3/GPCPD1/AGPAT1/PLA2G4A/PLD4/LCAT/CHKA/ETNK1/CHKB/DGKQ/PTDSS2/PISD/CRLS1/PCYT1A/DGKD/SAMD8/PLA2G4C/DGKE/GPD1L/MBOAT1/GDPD5/PLD2/ADPRM/DGKA	2.90089177683813
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	32/3000	66/9376	1.51531313131313	MAF/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DMB/IL18/HLA-DQA2/IFNGR2/HLA-DQA1/HLA-DRB1/HLA-DQB1/SMAD3/IL4R/JUN/STAT3/STAT6/TGFB3/NFKB1/HLA-DOA/IFNGR1/IL10/TLR2/TGFB2/TLR4/IL2RG/TLR5/RELA/IL18R1/IL12RB1/NFATC1/IL6	2.88164480440419
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	49/3000	110/9376	1.39219393939394	TIMP1/IL6R/VEGFA/CREBBP/IFNGR2/TFRC/CDKN1A/PRKCA/CAMK2D/PIK3R1/LTBR/CYBB/EIF4EBP1/STAT3/IGF1R/EGLN2/PFKM/AKT2/MAPK1/TEK/NFKB1/SERPINE1/PIK3CA/BCL2/IFNGR1/ANGPT1/PDHB/HK3/CAMK2A/PFKFB3/CDKN1B/TLR4/HIF1A/RPS6KB1/CUL2/NOS3/PRKCB/RELA/PIK3CD/PLCG2/EPAS1/EP300/ENO3/AKT3/IL6/ENO2/PIK3R2/PLCG1/MTOR	2.8380705308369
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	84/3000	205/9376	1.2806243902439	HLA-B/IL6ST/CCND2/HLA-A/CREB3L1/HLA-F/RBPJ/CREBBP/HLA-C/CCND3/ATP6V0D1/RBL2/GSN/CDK6/LYN/CDKN1A/HLA-E/PIK3R1/USP7/LTBR/JUN/STAT3/CDK4/UBE3A/KRAS/CHD4/TRADD/PRKACA/MAPK1/CREB1/SYK/NFKB1/CCND1/ATF2/PIK3CA/PRKACB/STAT5A/SP100/JAK3/UBR4/HDAC7/YWHAH/ATF6B/HDAC3/NFKBIA/NFKB2/CDKN1B/DLG1/HDAC9/MAPKAPK2/CREB3/MAD1L1/SCIN/GTF2H1/KAT2B/IKBKG/GTF2A1/RELA/EGR2/RB1/GTF2E2/CCR5/TRAF1/BAX/CREB5/HDAC4/VAC14/CDKN2B/STAT5B/PIK3CD/EP300/CASP3/GTF2H2/REL/GTF2H2C/SRC/HDAC10/C3/HDAC11/TRAF5/TBP/PIK3R2/HDAC6/ATF4	2.78654531424605
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	23/3000	44/9376	1.63369696969697	CREB3L1/ARHGDIG/ADCY3/AQP3/STX4/ADCY9/VAMP2/PRKACA/DYNC1LI2/CREB1/DYNC2H1/PRKACB/RAB5A/DCTN6/DYNC1H1/CREB3/ADCY6/RAB11B/RAB5C/DYNC2LI1/CREB5/DCTN4/RAB5B	2.88996587707243
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	48/3000	108/9376	1.38903703703704	UBE2I/TNPO1/NUP214/THOC2/TPR/KPNA5/UPF3A/RANBP2/POM121/KPNA3/PHAX/RNPS1/POM121C/AHCTF1/XPO6/DDX19A/SEC13/SUMO3/NXT1/SNUPN/DDX39B/NUP93/SENP2/NUP35/RAE1/DDX19B/NUP62/THOC6/IPO9/IPO8/NUP188/NMD3/NUP54/NUP133/IPO13/XPOT/NXF1/XPO4/NUP98/NUP153/KPNA1/NUP160/TNPO2/RANBP17/IPO11/NUP85/UPF2/XPO7	2.78921457200937
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	46/3000	103/9376	1.39577993527508	LAMA2/LAMB2/COL1A2/COL3A1/COL1A1/LAMC3/ITGB2/IL1R1/PRKCA/PIK3R1/FN1/PRKACA/TGFB3/PLCB1/NFKB1/PIK3CA/PRKACB/ITGAM/RAB5A/GNA15/COL4A5/CXCL3/IL10/TLR2/TGFB2/RAB7A/TLR4/GNA14/PLCB2/CXCL2/LAMB1/LAMC1/CD1D/HSPB1/PRKCB/RELA/RAB5C/CD14/GNA11/PIK3CD/CASP3/IL6/LAMB3/PIK3R2/CXCL1/RAB5B	2.77034825611288
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	44/3000	98/9376	1.40321088435374	ATP1B1/CREB3L1/ATP2B1/HSD3B2/CALM2/ADCY3/ITPR1/ATP1A1/PRKCA/CAMK2D/ORAI1/ADCY9/PRKACA/ADCY7/CREB1/PLCB1/ATF2/KCNK3/ATP1A2/PRKACB/ITPR2/CAMK2A/CAMK1D/ATF6B/CAMK1/NR4A2/PRKD2/PLCB2/CREB3/PRKD1/KCNJ5/PRKCB/LIPE/ADCY6/POMC/GNA11/ATP2B4/CREB5/SCARB1/CACNA1C/DAGLB/CACNA1G/ATP1B3/ATF4	2.75226477702429
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	42/3000	93/9376	1.41144086021505	TGFBR1/TGFBR2/LMO7/SSX2IP/CREBBP/SNAI2/SMURF2/SMAD3/FGFR1/WASL/FYN/ROCK1/IGF1R/RAP1A/SMAD4/ROCK2/MAPK1/WASF2/PTPN1/PTPRJ/KRIT1/TJP1/WAS/RAC2/PTPN6/CSNK2A1/TCF7L1/CCM2/SORBS1/MAP3K7/CSNK2A2/BAIAP2/CSNK2B/RAP1B/PTPRM/EP300/FER/SRC/RADIL/FARP2/MYL9/PARD3	2.73512279943453
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	31/3000	65/9376	1.49054358974359	CREB3L1/HSD3B2/ADCY3/ITPR1/ORAI1/ADCY9/PRKACA/ADCY7/CREB1/PLCB1/ATF2/KCNK3/MRAP/PRKACB/ITPR2/NCEH1/PBX1/ATF6B/SP1/PLCB2/CREB3/ADCY6/POMC/GNA11/CREB5/SCARB1/PDE8A/CACNA1C/PDE8B/CACNA1G/ATF4	2.72212604740724
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	93/3000	233/9376	1.24745064377682	DES/ATP1B1/LAMA2/FMNL2/COL5A2/SDC2/FHL1/CSRP2/SGCE/VCAN/TNNT1/COL6A1/TNNI3/DCN/COL6A2/FBLN1/COL1A2/VIM/COL3A1/COL1A1/FBN1/FBLN2/COL5A1/TNNT3/SPTBN1/ITGA1/NID1/ELN/PDLIM7/BGN/ATP1A1/PDLIM4/SYNPO2/SGCA/THBS1/FMNL1/SNTB1/SUN1/TMEM43/ANK2/SPTAN1/SGCB/SGCD/SYNE1/MYH10/ITGB5/DAAM1/FN1/SNTB2/ITGA11/CAPZA2/AMPD2/FHL3/SNTA1/ATP1A2/LMOD1/PLEC/MYL3/COL4A5/ITGA4/LMNA/DMD/PDLIM3/TLN2/COL11A1/THBS3/FMNL3/COL6A6/PDLIM5/TRIM63/COL5A3/SYNE2/MYOM1/COL9A2/AMPD3/COL9A3/DTNA/MYOZ1/FLNC/ITGB7/NEB/ENO3/TNNT2/LBR/TMOD2/MYOM2/FBN2/MYL9/DAAM2/ENO2/TLN1/ATP1B3/NEBL	2.62357993040002
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	10/3000	15/9376	2.08355555555556	HEXA/HEXB/ST3GAL1/ST3GAL2/ST6GALNAC6/GLB1/ST3GAL5/ST6GALNAC4/B3GALT4/ST6GALNAC3	2.88076479789016
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	20/3000	38/9376	1.64491228070175	PGM3/GCK/HEXA/HEXB/GFPT2/GNPDA1/HK3/RENBP/GNPDA2/UAP1L1/AMDHD2/CHIT1/GALK1/GMPPA/PMM2/GALK2/FPGT/UGDH/GALT/GFPT1	2.73235813144008
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	65/3000	157/9376	1.29392781316348	CCND2/WNT2/TGFBR1/TGFBR2/YAP1/FZD2/BMP5/GDF6/WNT2B/WNT5B/CCND3/ITGB2/SNAI2/FZD1/BMPR2/SMAD3/FZD7/APC/SMAD7/PPP2CB/BMPR1A/SMAD4/GLI2/TGFB3/CCND1/SERPINE1/LATS2/BIRC3/BIRC2/YWHAH/TGFB2/BMP4/LLGL2/DVL3/MYC/DVL2/FBXW11/FZD4/BMP6/PRKCI/DLG3/DLG1/ID2/DLG4/TCF7L1/BBC3/WTIP/NF2/AJUBA/LATS1/FZD6/PPP2R2D/BTRC/CSNK1D/GSK3B/TP53BP2/SAV1/NKD2/WNT11/RASSF1/MOB1A/WNT3/MOB1B/PARD3/PARD6G	2.54753825079649
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	28/3000	59/9376	1.48320903954802	FOXO3/GADD45B/CDKN1A/PIK3R1/APC/PDPK1/KRAS/POLK/AKT2/MAPK1/CCND1/PIK3CA/SOS1/DDB2/MYC/PTEN/TCF7L1/GADD45G/ILK/ARAF/RAF1/SOS2/BAX/GSK3B/PIK3CD/AKT3/PIK3R2/ELK1	2.55384843676477
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	41/3000	93/9376	1.37783512544803	CALM2/ADCY3/ITPR1/MAPK14/PRKCA/CAMK2D/MAP3K2/ADCY9/JUN/KRAS/PRKACA/MAPK1/ADCY7/PLCB1/PLD1/PRKACB/SOS1/HBEGF/ITPR2/CAMK2A/MAPK7/MAP3K3/MAP2K4/PLCB2/MAP3K1/RAF1/PRKCD/PRKCB/ADCY6/PLA2G4A/SOS2/MAPK8/MAP2K7/GNA11/PLA2G4C/CACNA1C/SRC/MAPK10/ELK1/ATF4/PLD2	2.51172298614181
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	11/3000	18/9376	1.90992592592593	NEU1/HEXA/FUCA2/HEXB/MANBA/GLB1/FUCA1/MAN2B2/MAN2C1/ENGASE/MAN2B1	2.65046993802156
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	64/3000	156/9376	1.28218803418803	TNFRSF1A/CD81/CDK6/CDKN1A/PIK3R1/STAT3/PIAS1/CDK4/FAS/KRAS/CLDN11/PPP2CB/TRADD/AKT2/MAPK1/IFNAR1/SOCS3/NFKB1/CCND1/PIK3CA/BID/NR1H3/SOS1/RIPK1/YWHAH/CFLAR/MYC/NFKBIA/CLDN23/RNASEL/ARAF/RAF1/CXCL10/MX2/PPP2R2D/TLR3/IKBKG/IKBKB/SOS2/RELA/PPARA/RB1/EIF3E/BAX/TICAM1/SCARB1/GSK3B/IKBKE/PIK3CD/FADD/TRAF6/CLDN15/CASP3/APAF1/AKT3/CLDN12/TYK2/OAS2/RXRA/PIK3R2/IFIT1/E2F1/CHUK/CLDN1	2.43785316600358
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	49/3000	115/9376	1.33166376811594	CREB3L1/SLC18A3/ADCY3/ITPR1/PRKCA/CAMK2D/PIK3R1/GNAI1/GNAI2/GNG11/ADCY9/FYN/GNB4/KRAS/PRKACA/AKT2/MAPK1/ADCY7/CREB1/PLCB1/PIK3CA/PRKACB/BCL2/ITPR2/JAK2/CAMK2A/PIK3R5/CHRM2/CHAT/PLCB2/CREB3/KCNJ12/PRKCB/ADCY6/FOS/GNB2/GNA11/CREB5/GNGT2/PIK3CD/KCNJ2/AKT3/GNB3/KCNQ1/CACNA1C/PIK3R2/ATF4/GNG12/GNGT1	2.45465307282023
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	61/3000	148/9376	1.28814414414414	WNT2/FZD2/FGF7/WNT2B/NOTCH2/WNT5B/JAG1/GADD45B/CDK6/CDKN1A/FZD1/PIK3R1/FZD7/FGF2/FGFR1/APC/HES1/JUN/CDK4/IGF1R/KRAS/POLK/AKT2/MAPK1/SHC2/NCOA1/LRP5/CCND1/PIK3CA/SOS1/LRP6/DDB2/DVL3/MYC/PTEN/DVL2/FZD4/SP1/NFKB2/TCF7L1/GADD45G/RPS6KB1/ARAF/RAF1/SHC1/FZD6/SOS2/RB1/FOS/BAX/GSK3B/DLL4/WNT11/PIK3CD/AKT3/WNT3/NOTCH1/PIK3R2/HEYL/MTOR/E2F1	2.42358900803349
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	32/3000	70/9376	1.42872380952381	HGF/VEGFA/CREBBP/CDKN1A/PIK3R1/JUN/KRAS/EGLN2/RAP1A/AKT2/MAPK1/TGFB3/PIK3CA/SOS1/TGFB2/PRCC/TFE3/HIF1A/ARAF/RAF1/GAB1/CUL2/FLCN/SOS2/CRK/RAP1B/PIK3CD/EPAS1/EP300/AKT3/ETS1/PIK3R2	2.46954651299317
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	16/3000	30/9376	1.66684444444444	PIGC/PIGT/PIGM/PIGH/PIGQ/PIGP/GPAA1/PIGX/PIGL/PIGV/PGAP3/B3GALT4/MPPE1/PIGF/PIGU/PIGN	2.5092526284603
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	29/3000	63/9376	1.4386455026455	WNT2/FZD2/WNT2B/WNT5B/GADD45B/CDKN1A/FZD1/SMO/FZD7/APC/POLK/GLI2/SUFU/GLI3/BMP4/DDB2/DVL3/DVL2/FZD4/TCF7L1/GADD45G/FZD6/BAX/GSK3B/WNT11/PTCH1/WNT3/KIF7/PTCH2	2.39613490461983
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	20/3000	41/9376	1.52455284552846	VEGFA/DAPK1/CDKN1A/THBS1/MMP9/TYMP/CDK4/KRAS/MAPK1/CCND1/HBEGF/MYC/ARAF/RAF1/FGFR3/RB1/RASSF1/SRC/DAPK3/E2F1	2.30885216381738
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	97/3000	254/9376	1.19353280839895	HGF/PDGFRA/ATP2B1/FGF7/ORAI3/CALM2/ADCY3/VEGFA/PDGFC/ADRB3/ITPR1/PDGFA/PRKCA/CAMK2D/VEGFC/GDNF/CXCR4/FGFR2/PDGFRB/FGF2/ORAI1/ADCY9/CYSLTR2/FGFR1/SLC8A1/NFATC4/ORAI2/EDNRB/NFATC3/ADORA2B/PRKACA/PTAFR/PTGFR/ADCY7/MCOLN1/PTGER1/PLCB1/FGFR4/PRKACB/TPCN1/MCOLN2/ITPR2/GNA15/TBXA2R/P2RX7/P2RX4/NFATC2/PPP3CB/PLCD3/CAMK2A/CAMK1D/BDKRB1/CAMK1/PHKB/SPHK1/VEGFB/PPP3CC/CHRM2/GNA14/PLCB2/HRH2/P2RX6/HRC/FGFR3/PLCE1/ASPH/GRIN2D/RYR2/NOS3/PRKCB/MST1R/ATP2A2/GNA11/ATP2B4/TFEB/CD38/MYLK/PPP3R1/PLCG2/ITPKA/ITPKC/P2RX1/TPCN2/MCOLN3/ITPKB/CACNA1C/NFATC1/MYLK3/CACNA1G/NTRK2/RYR1/PLCG1/HRH1/SPHK2/ATP2A3/ADRB2/PDE1A	2.14485794793374
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	38/3000	89/9376	1.33441198501873	GJA1/PDGFRA/ADCY3/PDGFC/ITPR1/PRKG1/PDGFA/PRKCA/LPAR1/GNAI1/GNAI2/PDGFRB/MAP3K2/ADCY9/KRAS/GUCY1A2/PRKACA/MAP2K5/MAPK1/ADCY7/PLCB1/TUBB2A/PRKACB/SOS1/ITPR2/TJP1/MAPK7/TUBA1A/PLCB2/RAF1/PRKCB/ADCY6/SOS2/GNA11/CSNK1D/TUBA3D/TUBA4A/SRC	2.1742587458358
Human Diseases	Immune disease	hsa05330	Allograft rejection	19/3000	39/9376	1.52259829059829	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DMB/HLA-C/HLA-DQA2/HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-E/CD86/FAS/HLA-DOA/IL10/CD40	2.24320373967987
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	17/3000	34/9376	1.56266666666667	FBXL3/CREB1/CLOCK/CRY2/PER1/FBXW11/PRKAA1/NR1D2/PER3/PRKAG2/BTRC/CSNK1D/PRKAG1/DBP/CRY1/BHLHE41/PRKAB1	2.25446151469034
Human Diseases	Cancer: specific types	hsa05218	Melanoma	32/3000	73/9376	1.37000913242009	HGF/PDGFRA/FGF7/PDGFC/GADD45B/CDK6/PDGFA/CDKN1A/PIK3R1/PDGFRB/FGF2/FGFR1/CDK4/IGF1R/KRAS/POLK/AKT2/MAPK1/CCND1/PIK3CA/DDB2/PTEN/MITF/GADD45G/ARAF/RAF1/RB1/BAX/PIK3CD/AKT3/PIK3R2/E2F1	2.17687992437804
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	24/3000	52/9376	1.44246153846154	CD36/APOC1/APOE/ANGPTL4/LRP1/CYP27A1/PLTP/ABCA1/LPL/LIPA/SOAT1/STARD3NL/NCEH1/SORT1/STARD3/NPC1/LDLRAP1/TSPO/MYLIP/APOC2/LRPAP1/LCAT/SCARB1/OSBPL5	2.19456362174491
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	60/3000	150/9376	1.25013333333333	HGF/WNT2/TGFBR1/TGFBR2/FZD2/FGF7/WNT2B/WNT5B/GADD45B/CDKN1A/FZD1/RARB/PIK3R1/SMAD3/FZD7/FGFR2/FGF2/APC/KRAS/POLK/SMAD4/AKT2/MAPK1/SHC2/TGFB3/LRP5/CCND1/PIK3CA/RXRB/BCL2/SOS1/LRP6/TGFB2/DDB2/DVL3/MYC/DVL2/FZD4/CDKN1B/TCF7L1/GADD45G/RPS6KB1/ARAF/RAF1/GAB1/SHC1/FZD6/SOS2/RB1/BAX/GSK3B/CDKN2B/WNT11/PIK3CD/AKT3/WNT3/RXRA/PIK3R2/MTOR/E2F1	2.11827619855935
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	28/3000	63/9376	1.38903703703704	PLOD2/KMT2E/KMT2A/PRDM6/ALDH9A1/ASH1L/SETD2/PHYKPL/NSD1/KMT2B/ALDH3A2/COLGALT1/PLOD3/EZH1/SETD7/KMT2C/SETDB2/EHMT2/SETD1A/TMLHE/SETD1B/PRDM2/EHMT1/SETDB1/DLST/SMYD3/ALDH2/KMT2D	2.12514483338424
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	16/3000	32/9376	1.56266666666667	GABARAPL2/GABARAP/GABARAPL1/PPP2CB/WIPI2/ULK2/PIK3C3/ATG7/MLST8/ATG4B/PIK3R4/ATG4D/ATG2B/ATG2A/ATG4A/MTOR	2.18691484793968
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	42/3000	101/9376	1.29964356435644	WNT2/CREB3L1/FZD2/WNT2B/CALM2/ADCY3/WNT5B/CREBBP/KITLG/PRKCA/CAMK2D/FZD1/GNAI1/GNAI2/FZD7/ADCY9/KRAS/EDNRB/PRKACA/MAPK1/ADCY7/CREB1/PLCB1/PRKACB/CAMK2A/DVL3/DVL2/FZD4/MITF/PLCB2/TCF7L1/CREB3/RAF1/FZD6/PRKCB/ADCY6/POMC/GSK3B/WNT11/EP300/WNT3/MC1R	2.07673361958401
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	24/3000	53/9376	1.41524528301887	ATP1B1/ATP2B1/AP2M1/ATP1A1/PRKCA/ADCY9/SLC8A1/PTH1R/VDR/PRKACA/PLCB1/CLTC/ATP1A2/PRKACB/AP2A1/PLCB2/DNM1/PRKCB/ADCY6/AP2B1/AP2S1/ATP2B4/AP2A2/ATP1B3	2.07939460010784
Organismal Systems	Endocrine system	hsa04924	Renin secretion	30/3000	69/9376	1.35884057971014	CALM2/ADRB3/ITPR1/PDE3A/GNAI1/GNAI2/PTGER2/ORAI1/CTSB/PDE3B/PTGER4/GUCY1A2/PRKACA/CREB1/PLCB1/KCNMA1/REN/PRKACB/ITPR2/PPP3CB/PPP3CC/PLCB2/ADCY6/PPP3R1/AQP1/KCNJ2/ADORA1/CACNA1C/ADRB2/PDE1A	2.05207556654949
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	88/3000	232/9376	1.18547126436782	PDGFRA/IQGAP2/FGF7/C7/ITGA1/CFL2/RRAS/ENAH/RGCC/PDGFC/ITGB2/PFN2/GSN/TMSB4X/PDGFA/LPAR1/PIK3R1/CXCR4/FGFR2/PDGFRB/GNA13/FGF2/FGFR1/ARHGAP35/APC/WASL/MYH10/ITGB5/ROCK1/BCAR1/FN1/NCKAP1L/KRAS/ITGAX/ITGA11/ROCK2/AKT2/MAPK1/MRAS/WASF2/MSN/LIMK1/FGFR4/ABI2/PIK3CA/ITGAM/SOS1/PIP4K2A/ITGA4/RAC2/BDKRB1/ITGAL/PIKFYVE/ARHGEF12/FGD1/SSH1/CHRM2/VAV1/PPP1R12A/ARAF/RAF1/PPP1R12B/FGFR3/NCKAP1/SCIN/LPAR5/SOS2/KNG1/CRK/BAIAP2/PIP5K1C/PIP4K2B/MYLK/PIK3CD/SLC9A1/ARHGEF6/ITGB7/AKT3/DOCK1/SPATA13/SRC/MYLK3/PIP5K1A/MYL9/PPP1R12C/PIK3R2/ARHGEF7/GNG12	1.9621157672216
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	35/3000	83/9376	1.31791164658635	IFI16/CASP1/IL18/SAMHD1/AIM2/POLR3GL/ZCCHC3/NFKB1/ZDHHC1/TREX1/RIPK1/POLR3D/DNASE2/PYCARD/NFKBIA/ADAR/CASP7/CXCL10/IKBKG/POLR3E/IKBKB/RELA/RIPK3/IKBKE/FADD/MLKL/NLRP3/POLR2K/CASP3/IL6/POLR3A/CCL5/PCBP1/POLR3C/CHUK	1.99544438198366
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	10/3000	18/9376	1.7362962962963	THAP11/LMBRD1/ABCD4/MTR/TCN2/MMADHC/MMAA/HCFC1/MTRR/ZNF76	2.14471435883542
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	53/3000	133/9376	1.2454335839599	HLA-B/HLA-A/FCGR3A/HLA-C/IFNGR2/ITGB2/SH3BP2/TYROBP/PRKCA/HLA-E/PIK3R1/CD48/FCER1G/FYN/HCST/FAS/KRAS/ICAM1/MAPK1/SHC2/IFNAR1/SYK/PIK3CA/BID/LCP2/SOS1/IFNGR1/NFATC2/PPP3CB/LAT2/RAC2/ITGAL/PTPN6/PPP3CC/VAV1/ARAF/RAF1/SHC1/LAT/PRKCB/ICAM2/SOS2/MICA/PPP3R1/PIK3CD/PLCG2/MICB/TNFRSF10B/CASP3/NFATC1/TNFRSF10A/PIK3R2/PLCG1	1.95535422712819
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	18/3000	38/9376	1.48042105263158	ATP1B1/IRS1/ATP1A1/PRKCA/PIK3R1/PDPK1/KRAS/MAPK1/HSD11B2/PIK3CA/ATP1A2/NR3C2/PRKCB/PIK3CD/NEDD4L/SGK1/PIK3R2/ATP1B3	2.03544328268104
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	26/3000	59/9376	1.37726553672316	ADCY3/IRS1/ADRB3/PRKG1/PIK3R1/GNAI1/GNAI2/ADCY9/PDE3B/PRKACA/AKT2/ADCY7/NPY1R/PIK3CA/PRKACB/PTGS1/LIPE/PTGS2/ADCY6/FABP4/PNPLA2/PIK3CD/ADORA1/AKT3/PIK3R2/ADRB2	1.9939175850412
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	55/3000	139/9376	1.23664268585132	CREB3L1/CTSD/CALM2/ADCY3/ITPR1/HSPA1A/PIK3R1/GNAI1/GNAI2/MMP9/ADCY9/JUN/RARA/KRAS/PRKACA/AKT2/MAPK1/SHC2/ADCY7/CREB1/PLCB1/EBAG9/NCOA1/ATF2/PIK3CA/HSPA1B/PRKACB/BCL2/SOS1/HBEGF/ITPR2/ATF6B/HSPA6/SP1/NCOA2/HSP90B1/GABBR1/PLCB2/CREB3/RAF1/SHC1/KCNJ5/PRKCD/NOS3/ADCY6/POMC/SOS2/FOS/CREB5/PIK3CD/AKT3/SRC/GPER1/PIK3R2/ATF4	1.92800042599636
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	41/3000	100/9376	1.28138666666667	CD36/HLA-DRA/CSF1/MME/HLA-DPA1/EPOR/CD44/HLA-DPB1/IL6R/ITGA1/CD7/HLA-DMA/CD9/HLA-DMB/IL11RA/KITLG/HLA-DQA2/HLA-DQA1/HLA-DRB1/TFRC/HLA-DQB1/IL1R1/CD37/ANPEP/IL4R/CD4/FCGR1A/HLA-DOA/ITGAM/ITGA4/CD33/CD22/IL11/IL7R/CD1D/CD14/FLT3LG/CD38/IL6/CD19/CD59	1.94041782821604
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	9/3000	16/9376	1.758	GBGT1/HEXA/HEXB/ST3GAL1/ST3GAL2/GLA/NAGA/B3GALNT1/A4GALT	2.08143754428232
NA	NA	hsa04517	IgSF CAM signaling	110/3000	299/9376	1.14978818283166	NRP2/PMP22/LMO7/CLMP/SLIT3/SLIT2/EPB41L2/SSX2IP/SPTBN1/PTPRD/CASK/MBP/CD84/ITGB2/ABL1/NFASC/MAPK14/NRP1/LYN/PRKCA/PIK3R1/CD48/CD86/ANK2/SPTAN1/MPDZ/FGFR1/WASL/MYH10/FYN/PLXNA2/BCAR1/PLXNA4/PDPK1/PPFIA1/DOK1/ICAM1/ITGAX/RAP1A/IL1RAPL1/AKT2/MAPK1/DOK2/MSN/UNC5B/TUBB2A/PIK3CA/CADM3/LCP2/ITGAM/NLGN4Y/TJP1/ITGA4/SLAMF7/ROBO1/ITGAL/CADM1/TUBA1A/MAGI2/ERC1/PRKCI/PTPN6/ROBO3/JAM3/RAPGEF2/VAV1/ROBO2/SORBS1/NCAM2/CSK/PRKCB/INPP5D/ICAM2/PLXNA1/MAPK8/CABLES2/CABLES1/BAIAP2/NCK1/CRTAM/GSK3B/TUBA3D/RAP1B/NRCAM/MYLK/EPB41L1/PIK3CD/PLCG2/NCK2/TRAF6/PPFIA4/TUBA4A/UNC5C/AKT3/CNTNAP1/PPFIA3/PLXNA3/SRC/MAG/MYLK3/NLGN2/LRFN5/MAPK10/MYL9/TRPC6/PIK3R2/PLCG1/PARD3/PARD6G/NLGN4X	1.80556900101307
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	20/3000	44/9376	1.42060606060606	TAF7/GTF2I/TAF12/TAF1/GTF2H1/GTF2F1/GTF2A1/GTF2E2/CCNH/GTF2F2/TAF6/TAF8/ERCC3/GTF2H2/GTF2H2C/TAF2/TBP/TAF4/TAF3/TAF9B	1.91816786408594
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/3000	14/9376	1.78590476190476	CHST2/ST3GAL1/ST3GAL2/B4GALT4/B4GALT2/B4GALT3/ST3GAL3/CHST1	2.01846736035529
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	52/3000	133/9376	1.22193483709273	CREB3L1/CALM2/ITPR1/MAPK14/PRKCA/CAMK2D/GNAI1/GNAI2/GNG11/ARRB2/GNB4/PPP2CB/COMT/PRKACA/AKT2/CREB1/PLCB1/ATF2/PRKACB/CLOCK/ITPR2/PPP3CB/CAMK2A/PPP2R5E/ATF6B/KIF5B/ARRB1/PPP3CC/PLCB2/CREB3/KCNJ5/PPP2R2D/GSK3A/PPP2R3C/PRKCB/MAPK8/FOS/GNB2/PPP2R5A/CREB5/GNGT2/GSK3B/AKT3/GNB3/DRD4/CACNA1C/MAOA/PPP2R5B/MAPK10/ATF4/GNG12/GNGT1	1.76814116004264
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	14/3000	29/9376	1.5087816091954	YAP1/DCHS1/LATS2/RASSF4/FAT4/WTIP/NF2/AJUBA/LATS1/RASSF2/SAV1/RASSF1/MOB1A/MOB1B	1.88220270643619
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	22/3000	50/9376	1.37514666666667	HLA-DRA/HLA-DPA1/HLA-DPB1/TNFSF13B/HLA-DMA/HLA-DMB/HLA-DQA2/HLA-DQA1/HLA-DRB1/HLA-DQB1/CXCR4/CD86/LTBR/HLA-DOA/ITGA4/ICOSLG/IL10/CD40/CCL28/ITGB7/IL6/CCR10	1.82435982500029
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	38/3000	94/9376	1.26343262411348	MAPK14/MMP9/JUN/TRADD/MAPK1/IL17RC/TAB2/NFKB1/JUND/MAPK7/CXCL3/CEBPB/NFKBIA/HSP90B1/CCL7/CXCL2/CXCL10/MAP3K7/IKBKG/IKBKB/PTGS2/MAPK8/RELA/FOS/GSK3B/TNFAIP3/IKBKE/FADD/TRAF6/CCL20/CASP3/IL6/MAPK10/IL17RE/TRAF5/CXCL1/TAB3/CHUK	1.76069776978089
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	17/3000	37/9376	1.43596396396396	GADD45B/CDKN1A/KRAS/POLK/MAPK1/CCND1/TPR/RXRB/TFG/DDB2/MYC/TCF7L1/GADD45G/BAX/CCDC6/RXRA/PAX8	1.82252451346101
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	81/3000	217/9376	1.16659907834101	CREB3L1/KLF4/FGF7/GSTT1/AHR/ADCY3/VEGFA/NOTCH2/CCND3/PAQR8/ADRB3/JAG1/PRKCA/PIK3R1/GNAI1/GNAI2/FGF2/ADCY9/EIF4EBP1/JUN/STAT3/ARRB2/GSTM3/KRAS/AIP/VDR/PRKACA/AKT2/MAPK1/ADCY7/RPS6KA3/CREB1/EPHX1/NFKB1/CCND1/ATF2/PIK3CA/RXRB/EPHX2/PRKACB/STAT5A/BCL2/SOS1/KPNA5/JAK2/MGST2/ATF6B/MYC/ARRB1/XIAP/HSP90B1/KPNA3/CREB3/RPS6KB1/RAF1/PRKCB/MIR29A/ADCY6/SOS2/GSTO1/RELA/PPARA/RB1/FOS/CREB5/DLL4/IKBKE/STAT5B/PIK3CD/BCL6/GSTM2/AKT3/CACNA1C/SRC/RXRA/PIK3R2/KPNA1/MTOR/ATF4/E2F1/ADRB2	1.70314076211533
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	31/3000	75/9376	1.29180444444444	ATP1B1/CREB3L1/GPX7/ADCY3/ITPR1/ATP1A1/PRKCA/GPX8/ADCY9/PRKACA/ADCY7/CREB1/ASGR1/PLCB1/ATF2/ATP1A2/PRKACB/ITPR2/ATF6B/HSP90B1/PLCB2/CREB3/PRKCB/ADCY6/CREB5/GSR/PAX8/GPX1/ATP1B3/ATF4/TTF1	1.74032285311064
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	59/3000	154/9376	1.19736796536797	ATP1B1/CREB3L1/ATP2B1/TNNI3/CALM2/ADCY3/MAPK14/ATP1A1/PRKCA/CAMK2D/GNAI1/GNAI2/ADCY9/SLC8A1/CACNA2D1/PPP2CB/PRKACA/AKT2/MAPK1/ADCY7/CREB1/PLCB1/ATF2/ATP1A2/PRKACB/BCL2/MYL3/CAMK2A/PIK3R5/PPP2R5E/ATF6B/CACNB4/PLCB2/CREB3/CACNA2D4/PPP2R2D/PPP2R3C/RYR2/ADCY6/SCN7A/PPP2R5A/ATP2A2/ATP2B4/CREB5/SLC9A1/CACNB2/AKT3/TNNT2/KCNQ1/CACNA1C/PPP2R5B/SCN1B/KCNE1/CACNB3/CACNB1/ATP1B3/ATF4/ATP2A3/ADRB2	1.69393435811784
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	46/3000	117/9376	1.22876353276353	SMARCA1/RSF1/BPTF/BAZ2B/SMARCD3/CHD4/SMARCC2/BCL7C/EPC1/DPF2/MEAF6/GATAD2B/ARID1B/INO80D/MTA1/EPC2/MRGBP/CHRAC1/BAZ1B/PHF10/PBRM1/BCL7B/BRD7/TFPT/KAT5/BAZ2A/SMARCE1/CHD3/ARID1A/ING3/SRCAP/MCRS1/SMARCD2/INO80/TRRAP/EP400/YY1/INO80B/ACTR8/BCL7A/ARID2/SS18L1/INO80E/BRD8/ZNHIT1/ACTR5	1.70792892965755
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	6/3000	10/9376	1.8752	SELENBP1/PAPSS2/TST/PAPSS1/BPNT1/SUOX	1.89933837780347
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	42/3000	107/9376	1.22676635514019	CREB3L1/CALM2/CREBBP/FBP1/ITPR1/GCK/CAMK2D/PDE3B/PFKM/PRKACA/AKT2/CREB1/PLCB1/ATF2/PRKACB/CPT1A/ITPR2/PDHB/PPP3CB/CAMK2A/SIK2/G6PC3/PRKAA1/PHKB/PPP3CC/PPP4C/PLCB2/CREB3/SIRT1/PPARA/PRKAG2/CREB5/PPP3R1/ACACB/EP300/PRKAG1/AKT3/SIK1/PRKAB1/CRTC2/PYGB/ATF4	1.6181775764913
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	33/3000	82/9376	1.25775609756098	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-DPA1/CD74/HLA-DPB1/CTSS/HLA-DMA/B2M/HLA-DMB/HLA-C/HLA-DQA2/HLA-DQA1/HLA-DRB1/HSPA1A/HLA-DQB1/HLA-E/CD4/CTSB/IFI30/LGMN/TAPBP/CREB1/HSPA1B/HLA-DOA/TAPBPL/HSPA6/CIITA/NFYC/RFX5/RFXANK/RFXAP	1.60800224730701
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	45/3000	116/9376	1.21241379310345	VCAM1/CD99/ARHGAP5/ITGB2/NCF2/MAPK14/PRKCA/PIK3R1/GNAI1/GNAI2/CXCR4/MMP9/CYBB/ARHGAP35/ROCK1/BCAR1/CLDN11/ICAM1/RAP1A/ROCK2/RASSF5/MSN/PIK3CA/ITGAM/ITGA4/RAC2/ITGAL/CLDN23/JAM3/VAV1/CD99L2/PRKCB/SIPA1/NCF4/RAP1B/PIK3CD/PLCG2/CLDN15/CLDN12/RHOH/MYL9/PIK3R2/CYBA/PLCG1/CLDN1	1.57898617280163
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	21/3000	49/9376	1.33942857142857	CREB3L1/GNAI1/GNAI2/JUN/GPSM1/PRKACA/CREB1/NFKB1/ATF2/PRKACB/ATF6B/BDNF/DLG4/CREB3/CDK5/GRIN2D/RELA/RGS9/CREB5/MAOA/ATF4	1.63398309588123
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	35/3000	88/9376	1.2430303030303	F3/CLU/F10/VTN/SERPINE2/C7/CFD/PROS1/PLAUR/C1R/ITGB2/SERPINA1/PLAT/C3AR1/C5AR1/C1S/A2M/C2/ITGAX/C1QB/C1QA/SERPINE1/PLAU/CFH/C1QC/ITGAM/BDKRB1/VSIG4/SERPING1/CD46/KNG1/SERPIND1/THBD/C3/CD59	1.57113235556683
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	19/3000	44/9376	1.34957575757576	MAN1A1/MAN1C1/HEXA/MGAT2/HEXB/CHST9/MGAT4B/ALG1/ALG2/MAN1B1/MGAT1/ALG12/RPN1/ALG14/B4GALT2/B4GALT3/ST3GAL3/KRTCAP2/ALG11	1.59423519309045
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	38/3000	97/9376	1.22435738831615	CALM2/ADCY3/ITPR1/PRKG1/PRKCA/CAMK2D/GNAI1/GNAI2/GNG11/ADCY9/GNB4/GUCY1A2/PRKACA/MAPK1/ADCY7/CREB1/PLCB1/NOS1AP/PRKACB/CAMK2A/PER1/PLCB2/KCNJ5/GRIN2D/RYR2/PRKCB/ADCY6/PER3/FOS/GNB2/GNGT2/RASD1/GNB3/CACNA1C/CACNA1G/RYR1/GNG12/GNGT1	1.523518622062
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	18/3000	42/9376	1.33942857142857	SLC40A1/FTL/PRNP/TFRC/CYBB/ACSL3/FTH1/SAT2/SLC11A2/GCLM/ACSL1/ATG7/STEAP3/LPCAT3/MAP1LC3B/SLC39A14/SLC7A11/PCBP1	1.51220703658429
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	82/3000	226/9376	1.13397050147493	ATP1B1/CREB3L1/FXYD1/ATP2B1/TNNI3/CALM2/ADCY3/RRAS/CREBBP/ATP1A1/CAMK2D/PDE3A/PIK3R1/GNAI1/GNAI2/PTGER2/ORAI1/ADCY9/PDE3B/JUN/ROCK1/RAP1A/ROCK2/PRKACA/AKT2/MAPK1/ADCY7/PDE4A/CREB1/NPY1R/PLD1/NFKB1/PIK3CA/SSTR1/ATP1A2/PRKACB/PDE4B/GLI3/CAMK2A/RAC2/ARAP3/BDNF/NFKBIA/GABBR1/CHRM2/SUCNR1/VAV1/PPP1R12A/CREB3/RAF1/PLCE1/ABCC4/GRIN2D/RYR2/LIPE/ADCY6/POMC/MAPK8/RELA/PPARA/FOS/ATP2A2/ATP2B4/CREB5/RAP1B/VIPR2/PIK3CD/SLC9A1/ADORA1/GIP/EP300/PTCH1/AKT3/CACNA1C/NFATC1/MAPK10/MYL9/PIK3R2/ATP1B3/ATP2A3/PLD2/ADRB2	1.39837923682226
NA	NA	hsa03272	Virion - Hepatitis viruses	20/3000	48/9376	1.30222222222222	DPP4/CD81/CD63/CD9/IST1/TGOLN2/CLDN11/LAMP2/LAMP1/CHMP1A/CHMP1B/VPS4A/CLDN23/PDCD6IP/SCARB1/VPS4B/CLDN15/CLDN12/CHMP7/CLDN1	1.43987521436193
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	38/3000	99/9376	1.1996228956229	DES/LAMA2/SGCE/TNNI3/ITGA1/SGCA/SNTB1/SGCB/SGCD/SLC8A1/CACNA2D1/ITGB5/SNTB2/ITGA11/TGFB3/SNTA1/MYL3/ITGA4/LMNA/DMD/TGFB2/PRKAA1/CACNB4/CACNA2D4/RYR2/PRKAG2/ATP2A2/DTNA/PRKAG1/CACNB2/ITGB7/TNNT2/CACNA1C/IL6/CACNB3/PRKAB1/CACNB1/ATP2A3	1.36960799121622
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	26/3000	65/9376	1.25013333333333	SPP1/ITPR1/PRKCA/PIK3R1/ARRB2/KRAS/AKT2/MAPK1/TRPC1/PLCB1/PIK3CA/ITPR2/ARRB1/GABBR1/PLCB2/RAF1/KCNJ5/PRKCB/GNA11/PIK3CD/AKT3/CACNA1C/HCN3/GPER1/CACNA1G/PIK3R2	1.38804068838688
Human Diseases	Immune disease	hsa05310	Asthma	14/3000	32/9376	1.36733333333333	HLA-DRA/HLA-DPA1/HLA-DPB1/PRG2/HLA-DMA/HLA-DMB/HLA-DQA2/HLA-DQA1/HLA-DRB1/HLA-DQB1/FCER1G/HLA-DOA/IL10/CD40	1.4277133663682
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	32/3000	83/9376	1.20494779116466	CAT/ACSL3/DHRS4/PEX2/ABCD4/EPHX2/PEX6/HSD17B4/NUDT7/PEX11B/ACSL1/ACOX2/MLYCD/DECR2/GNPAT/PEX14/ABCD3/HMGCL/PEX12/MPV17/PEX26/PEX3/HMGCLL1/AMACR/AGPS/PEX10/SOD2/PEX1/NUDT19/PAOX/PEX11G/PEX5	1.28640118369619
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	13/3000	30/9376	1.35431111111111	MTHFR/ABCC3/NFKB1/MTR/ABCC4/IKBKG/IKBKB/RELA/SHMT2/SLC46A1/IL6/ABCC5/CHUK	1.33322860264499
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	28/3000	72/9376	1.21540740740741	MAPK14/CYLD/TRADD/NFKB1/ZNFX1/RIPK1/TBKBP1/IFIH1/AZI2/NFKBIA/ADAR/MAP3K1/CXCL10/PIN1/NLRX1/MAP3K7/IKBKG/IKBKB/MAPK8/RELA/IKBKE/OTUD5/FADD/TRAF6/RNF125/MAPK10/CASP10/CHUK	1.25853165173826
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	61/3000	168/9376	1.13479365079365	GLUL/TNFRSF1A/FTL/CASP1/CAPN2/IFNGR2/CAMK2D/CYBB/STAT3/CYLD/STAT6/SMPD1/FAS/TRADD/IFNAR1/FTH1/BID/BIRC3/STAT5A/BCL2/IFNGR1/BIRC2/RIPK1/JAK3/JAK2/CAMK2A/CFLAR/TRPM7/CHMP1A/SHARPIN/PYCARD/CHMP1B/VPS4A/SQSTM1/XIAP/TLR4/RBCK1/TLR3/SPATA2L/CHMP5/PLA2G4A/MAPK8/BAX/TICAM1/TNFAIP3/RIPK3/CHMP6/STAT5B/VPS4B/FADD/MLKL/NLRP3/TNFRSF10B/PLA2G4C/TNFRSF10A/TYK2/MAPK10/TRAF5/USP21/CHMP7/PYGB	1.2092428633162
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	18/3000	44/9376	1.27854545454545	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DMB/HLA-C/HLA-DQA2/HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-E/CD86/FAS/HLA-DOA/PTPRN2	1.27030252209496
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	30/3000	78/9376	1.20205128205128	PABPC4L/TOB1/XRN1/CNOT4/MPHOSPH6/PFKM/CNOT6L/BTG2/C1D/CNOT1/DDX6/CNOT2/TOB2/DCP1B/EXOSC6/CNOT8/DIS3L/ZCCHC7/DHX36/ENO3/CNOT3/EDC3/PATL1/DCP1A/DCP2/PAN3/PAN2/ENO2/PABPC5/CNOT10	1.22909726492403
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	19/3000	47/9376	1.26343262411348	SOCS1/IRS1/GCK/PIK3R1/MAPK1/SOCS3/PIK3CA/SOCS2/HK3/PRKCD/IKBKB/MAPK8/PIK3CD/SOCS4/CACNA1C/MAPK10/CACNA1G/PIK3R2/MTOR	1.24186118098797
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	58/3000	160/9376	1.13293333333333	HLA-B/HLA-A/VCAM1/HLA-DRA/SDC2/VCAN/HLA-F/HLA-DPA1/HLA-DPB1/CD99/GLG1/HLA-DMA/ALCAM/HLA-DMB/HLA-C/PTPRD/HLA-DQA2/ITGB2/HLA-DQA1/HLA-DRB1/NFASC/HLA-DQB1/HLA-E/CD86/CD4/CD58/PTPRC/CLDN11/ICAM1/CADM3/HLA-DOA/ITGAM/NLGN4Y/SPN/ITGA4/ICOSLG/ITGAL/CADM1/SIGLEC1/CLDN23/SELPLG/CD22/JAM3/CD99L2/CD40/NCAM2/NEO1/ICAM2/NRCAM/PTPRM/CLDN15/ITGB7/CNTNAP1/MAG/CLDN12/NLGN2/CLDN1/NLGN4X	1.16330813353741
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	8/3000	17/9376	1.47074509803922	PAPSS2/INMT/SEPHS2/MTR/PAPSS1/SEPSECS/TXNRD1/PSTK	1.33250134091509
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	26/3000	67/9376	1.21281592039801	CALM2/CREBBP/ITPR1/PRKCA/CAMK2D/KRAS/RAP1A/PRKACA/MAPK1/RPS6KA3/PLCB1/PRKACB/ITPR2/PPP3CB/CAMK2A/PPP3CC/PLCB2/ARAF/RAF1/GRIN2D/PRKCB/RAP1B/PPP3R1/EP300/CACNA1C/ATF4	1.19911852183824
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	20/3000	50/9376	1.25013333333333	CD36/HGF/VCAM1/SDC2/CD81/LRP1/IL18/ITGB2/THBS1/ICAM1/TGFB3/GYPC/IL10/TLR2/TGFB2/ITGAL/TLR4/THBS3/CD40/IL6	1.21641279204597
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	37/3000	99/9376	1.16805387205387	CALM2/ADCY3/ITPR1/MAPK14/IL1R1/PRKCA/CAMK2D/PIK3R1/PTGER2/ADCY9/PTGER4/TRPV2/PRKACA/ADCY7/PLCB1/PIK3CA/PRKACB/ITPR2/CAMK2A/BDKRB1/TRPV3/PLCB2/PRKCD/PRKCB/ADCY6/PLA2G4A/MAPK8/KNG1/PIK3CD/PLCG2/ASIC1/PLA2G4C/SRC/MAPK10/PIK3R2/PLCG1/HRH1	1.15301366309513
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	39/3000	105/9376	1.1608380952381	DES/LAMA2/SGCE/TNNI3/ITGA1/ADCY3/SGCA/SNTB1/SGCB/ADCY9/SGCD/SLC8A1/CACNA2D1/ITGB5/SNTB2/ITGA11/PRKACA/ADCY7/TGFB3/SNTA1/PRKACB/MYL3/ITGA4/LMNA/DMD/TGFB2/CACNB4/CACNA2D4/RYR2/ADCY6/ATP2A2/DTNA/CACNB2/ITGB7/TNNT2/CACNA1C/CACNB3/CACNB1/ATP2A3	1.13682179593031
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/3000	12/9376	1.56266666666667	GGCX/VKORC1L1/COQ7/COQ5/COQ4/NQO1	1.33777544276791
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	57/3000	158/9376	1.12749367088608	CCND2/CREBBP/CCND3/ABL1/RBL2/GADD45B/CDK6/CDKN1A/ATRX/SMAD3/NIPBL/CDK4/PPP2CB/SMAD4/ATM/TGFB3/CDC25B/CCND1/STAG2/YWHAH/PPP2R5E/TGFB2/CHEK2/MYC/CDKN1B/MAU2/CDC16/CDC27/GADD45G/ANAPC16/CDKN2D/STAG1/E2F4/MAD2L1BP/RAD21/MAD1L1/ANAPC13/RB1/FZR1/CCNH/ANAPC10/MAD2L2/PPP2R5A/ATR/ESCO1/GSK3B/CDKN2B/PDS5B/ANAPC7/EP300/ORC4/ORC3/PPP2R5B/ZBTB17/ANAPC2/E2F1/ORC5	1.1085899285856
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	18/3000	45/9376	1.25013333333333	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DMB/HLA-C/HLA-DQA2/HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-E/CD86/FAS/HLA-DOA/IL6	1.15368127602575
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	25/3000	65/9376	1.20205128205128	AGPAT4/ALDH9A1/AGPAT2/LPL/LPIN2/GLA/AGPAT3/ALDH3A2/AKR1A1/MBOAT2/GK/GPAT2/LPIN1/DGKH/AGPAT1/PNPLA2/DGAT1/DGKQ/DGKD/DGKE/ALDH2/MBOAT1/ABHD16A/DGKA/AGK	1.12122361658281
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	19/3000	48/9376	1.23711111111111	ALDH9A1/ACAA2/IL4I1/ALDH3A2/HADHB/IVD/AUH/ACADM/ACADS/HIBCH/ACSF3/HMGCL/MCEE/ABAT/HMGCLL1/BCAT1/ALDH2/AACS/ACAD8	1.12966680420896
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	37/3000	100/9376	1.15637333333333	IL6ST/TNFRSF1A/CSF1/CXCL14/IL6R/IL18/TNFRSF14/CXCR4/IL34/LTBR/CCL18/IL10RB/TNFRSF1B/CXCL3/IL10/CXCL9/IL2RG/CCL7/CXCL2/CXCL10/CCL23/XCL1/CCR5/IL18R1/TNFSF14/TNFRSF10D/TNFRSF10B/CCL28/CCL20/PF4/TNFRSF10A/IL6/CCL26/CCL5/CXCL1/CCR10/CCL3	1.07833682189716
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	15/3000	37/9376	1.26702702702703	PGM3/GCK/GFPT2/HK3/TGDS/UAP1L1/NANP/GALK1/GMPPA/PMM2/GALK2/FPGT/UGDH/GALT/GFPT1	1.11629249832585
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	32/3000	86/9376	1.16291472868217	ATP1B1/CREB3L1/ADCY3/ATP1A1/PRKCA/GCK/CAMK2D/ADCY9/VAMP2/PRKACA/ADCY7/CREB1/PLCB1/KCNMA1/ATF2/ATP1A2/PRKACB/CAMK2A/ATF6B/PLCB2/CREB3/RYR2/PRKCB/ADCY6/STX1A/GNA11/CREB5/PCLO/GIP/CACNA1C/ATP1B3/ATF4	1.041055371868
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	46/3000	128/9376	1.12316666666667	ENPP1/PAPSS2/ADCY3/NME3/NME4/PDE3A/ADCY9/IMPDH1/PDE3B/NUDT9/GUCY1A2/AMPD2/ADCY7/PDE4A/PDE4B/LACC1/NPR2/ENTPD4/PDE7B/AK1/ENTPD2/NT5C2/HPRT1/RRM2B/ADCY6/PDE6B/GMPR2/PAPSS1/AMPD3/NME7/CANT1/AK3/PRPS1/PDE8A/PDE9A/ENPP4/AK9/GMPR/PDE8B/PDE6D/ENTPD1/PDE6G/PDE7A/PDE5A/ADPRM/PDE1A	0.962379522821925
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	9/3000	21/9376	1.33942857142857	ENPP1/ALDH3A2/DPYD/CSAD/PANK3/AASDHPPT/BCAT1/ALDH2/PANK1	1.06809100861033
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	15/3000	38/9376	1.23368421052632	ENPP1/BST1/NADK2/SIRT2/NNT/NNMT/NAMPT/QPRT/NT5C2/SIRT1/CD38/NMNAT1/SARM1/NADK/SIRT3	0.990071009542489
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	28/3000	76/9376	1.15143859649123	ATP1B1/CALM2/ADCY3/ITPR1/ATP1A1/SLC4A2/PRKCA/CAMK2D/GNAI1/GNAI2/ADCY9/PRKACA/ADCY7/PLCB1/ATP1A2/PRKACB/ITPR2/CAMK2A/PLCB2/HRH2/PRKCB/ADCY6/MYLK/KCNJ2/SLC9A1/KCNQ1/MYLK3/ATP1B3	0.909230528454459
Human Diseases	Substance dependence	hsa05032	Morphine addiction	33/3000	91/9376	1.13336263736264	ADCY3/PRKCA/PDE3A/GNAI1/GNAI2/GNG11/ADCY9/PDE3B/ARRB2/GNB4/PRKACA/ADCY7/PDE4A/PRKACB/PDE4B/ARRB1/GABBR1/PDE7B/KCNJ5/PRKCB/ADCY6/GNB2/GRK5/GNGT2/PDE8A/ADORA1/GNB3/PDE8B/PDE7A/PDE1A/GNG12/GRK4/GNGT1	0.876871649492647
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	37/3000	103/9376	1.1226925566343	SLC16A10/COL15A1/COL14A1/ATP1B1/DPP4/COL5A2/COL16A1/COL8A2/COL6A1/COL6A2/COL1A2/COL3A1/COL1A1/MME/COL5A1/COL21A1/SLC7A7/ELN/ATP1A1/SLC38A2/KCNE3/SLC8A1/CPA1/ATP1A2/SLC1A5/COL4A5/XPNPEP2/COL11A1/COL6A6/COL5A3/COL9A2/SLC15A1/COL9A3/KCNQ1/COL13A1/COL7A1/ATP1B3	0.858813396069794
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/3000	56/9376	1.172	MAN1A1/MAN1C1/MGAT2/MGAT4B/ALG1/ALG2/ALG5/MAN1B1/MGAT3/DOLK/MGAT1/ALG12/RPN1/ALG14/ST6GAL2/B4GALT2/B4GALT3/DHRSX/KRTCAP2/ST6GAL1/ALG11	0.885496024227025
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	14/3000	36/9376	1.21540740740741	GALNT1/ST3GAL1/GALNT10/ST3GAL2/GALNT12/GALNT7/GALNT11/ST6GALNAC4/GCNT1/C1GALT1/B4GALT5/GALNT18/GALNT5/ST6GALNAC3	0.888199567426311
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	26/3000	71/9376	1.1444882629108	PDGFRA/GCK/GLS/PIK3R1/FGFR2/PDGFRB/FGFR1/KRAS/PFKM/AKT2/MAPK1/PIK3CA/SLC1A5/PDHB/HK3/MYC/PTEN/HIF1A/RAF1/FGFR3/SCO2/PIK3CD/AKT3/SIRT3/PIK3R2/MTOR	0.838254062478033
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	59/3000	170/9376	1.08467450980392	GATA4/AMOTL1/MPDZ/JUN/MYH10/ROCK1/ARHGEF2/CDK4/CLDN11/PPP2CB/RAP1A/ROCK2/PRKACA/MSN/STK11/CCND1/PRKACB/TJP1/WAS/LLGL2/TUBA1A/PRKAA1/PRKCI/CLDN23/DLG3/DLG1/YBX3/JAM3/RAPGEF2/MAP3K1/RUNX1/NF2/CD1D/PPP2R2D/MAPK8/MICALL2/MAP2K7/PRKAG2/TUBA3D/CLDN15/PRKAG1/TUBA4A/SYMPK/ARHGAP17/NEDD4L/AMOTL2/WHAMM/SYNPO/SRC/CLDN12/TJAP1/NEDD4/MAPK10/MYL9/PRKAB1/PARD3/PARD6G/CLDN1/ARHGEF18	0.764211868020762
Organismal Systems	Nervous system	hsa04730	Long-term depression	22/3000	60/9376	1.14595555555556	ITPR1/PRKG1/LYN/PRKCA/GNAI1/GNAI2/GNA13/IGF1R/KRAS/PPP2CB/GUCY1A2/MAPK1/PLCB1/ITPR2/PLCB2/ARAF/RAF1/PRKCB/PLA2G4A/GNA11/PLA2G4C/RYR1	0.777953478392839
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	27/3000	76/9376	1.11031578947368	CD36/ANGPTL4/CYP27A1/PLTP/LPL/OLR1/ACSL3/PDPK1/NR1H3/RXRB/CPT1A/GK/SCD5/ACADM/ME3/ACSL1/ILK/ACOX2/SORBS1/SLC27A1/FABP4/PPARA/ME1/FABP3/FABP5/FADS2/RXRA	0.662331042970533
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/3000	20/9376	1.25013333333333	LIPA/CYP24A1/SOAT1/LSS/SC5D/LBR/CYP2R1/HSD17B7	0.768092586298964
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	8/3000	20/9376	1.25013333333333	NPL/CYB5R3/TGDS/UAP1L1/NANP/CYB5R2/GMPPA/UGDH	0.768092586298964
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	9/3000	23/9376	1.22295652173913	POMGNT2/FKRP/FUT4/B4GALT2/FKTN/B4GALT3/POMT2/ST3GAL3/POMGNT1	0.734312198271253
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	14/3000	38/9376	1.15143859649123	CD4/ORAI1/PTPRC/BTK/JAK3/CIITA/IL2RG/CD40/IL7R/IKBKG/RFX5/RFXANK/RFXAP/CD19	0.64161358516297
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	31/3000	89/9376	1.08859925093633	SPP1/CD36/LAMA2/LAMB2/VTN/COL6A1/COL6A2/COL1A2/COL1A1/LAMC3/CD44/ITGA1/THBS1/ITGB5/FREM1/FN1/ITGA11/COL4A5/ITGA4/TNXB/THBS3/CD47/LAMB1/COL6A6/LAMC1/COL9A2/SV2A/COL9A3/ITGB7/LAMB3/NPNT	0.576049019929797
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	30/3000	86/9376	1.09023255813953	GJA1/DES/LAMA2/SGCE/ITGA1/SGCA/SNTB1/SGCB/SGCD/SLC8A1/CACNA2D1/ITGB5/SNTB2/ITGA11/SNTA1/ITGA4/LMNA/DMD/CACNB4/TCF7L1/CACNA2D4/RYR2/ATP2A2/DTNA/CACNB2/ITGB7/CACNA1C/CACNB3/CACNB1/ATP2A3	0.576602803984751
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	5/3000	12/9376	1.30222222222222	ASGR1/NPC1/CD46/NCAM2/FCGR2B	0.718552370523045
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	34/3000	99/9376	1.0733468013468	HLA-DRA/HLA-DPA1/HLA-DPB1/CFD/FCGR3A/HLA-DMA/HLA-DMB/C1R/HLA-DQA2/ITGB2/HLA-DQA1/HLA-DRB1/HLA-DQB1/FPR3/C3AR1/C5AR1/FCGR1A/C1S/C2/ICAM1/PTAFR/C1QB/C1QA/FCGR2A/CFH/HLA-DOA/C1QC/ITGAM/IL10/ITGAL/SELPLG/FPR1/C3/FCGR2B	0.503230678731852
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/3000	24/9376	1.172	EXT1/B3GAT3/HS2ST1/EXT2/B3GALT6/XYLT1/XYLT2/EXTL3/NDST1	0.578700596548043
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	24/3000	69/9376	1.08707246376812	CREB3L1/CALM2/PRKCA/CAMK2D/JUN/PRKACA/CREB1/ATF2/PRKACB/PPP3CB/CAMK2A/ATF6B/PPP3CC/CREB3/GRIN2D/PRKCB/SIRT1/FOS/STX1A/CREB5/PPP3R1/CACNA1C/MAOA/ATF4	0.497934975922024
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	22/3000	63/9376	1.09138624338624	POLD4/ERCC1/ERCC4/XPA/POLR2C/ERCC6/POLR2J3/DDB2/RFC1/POLR2B/POLR2M/XPC/GTF2H1/CCNH/UVSSA/POLD2/POLR2K/POLR2A/ERCC3/GTF2H2/GTF2H2C/ERCC5	0.499204405970686
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	19/3000	54/9376	1.09965432098765	HES1/ERCC1/POLK/ERCC4/REV1/WDR48/REV3L/TELO2/ATR/PALB2/FAN1/POLI/FANCL/USP1/POLH/FANCF/RMI2/TOP3B/SLX4	0.503744800281712
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/3000	54/9376	1.09965432098765	HLA-B/HLA-A/HLA-DRA/HLA-F/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DMB/HLA-C/HLA-DQA2/HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-E/CD86/FAS/HLA-DOA/IL10/CD40	0.503744800281712
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	17/3000	48/9376	1.10688888888889	ATP1B1/ATP1A1/PIK3R1/AKT2/PLCB1/PIK3CA/ATP1A2/HK3/G6PC3/PLCB2/SLC37A4/PRKCB/SLC2A5/PIK3CD/AKT3/PIK3R2/ATP1B3	0.509249983903007
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	35/3000	103/9376	1.06200647249191	PABPC4L/PPP2CB/FUS/PELO/FIP1L1/NUDT21/RNMT/UPF3A/GSPT2/PPP2R5E/CPSF7/WDR82/CSTF2T/RNPS1/DDX19A/PCF11/PPP2R2D/PPP2R3C/NXT1/DDX39B/PPP2R5A/CPSF2/SMG1/DDX19B/PAPOLG/SMG6/CSTF1/SYMPK/CPSF1/PPP2R5B/HBS1L/NXF1/CLP1/PABPC5/UPF2	0.434027871615775
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	39/3000	116/9376	1.05075862068966	GLUL/ADCY3/ITPR1/SLC38A2/PRKCA/GLS/SLC1A3/GNAI1/GNAI2/GNG11/ADCY9/HOMER3/GNB4/PRKACA/MAPK1/ADCY7/TRPC1/PLCB1/PLD1/PRKACB/ITPR2/PPP3CB/PPP3CC/DLG4/PLCB2/GRIN2D/PRKCB/ADCY6/PLA2G4A/GNB2/GNGT2/PPP3R1/GNB3/NCDN/PLA2G4C/CACNA1C/PLD2/GNG12/GNGT1	0.377316176357793
Organismal Systems	Digestive system	hsa04978	Mineral absorption	21/3000	61/9376	1.07593442622951	SLC40A1/ATP1B1/ATP2B1/FTL/CYBRD1/ATP1A1/SLC8A1/VDR/FTH1/SLC31A1/ATP1A2/SLC11A2/TRPM7/SLC39A4/CLCN2/ATP7A/HMOX2/SLC30A1/ATP2B4/SLC46A1/ATP1B3	0.408116651736294
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	37/3000	110/9376	1.05124848484848	ADCY3/MAPK14/PIK3R1/GNAI1/GNAI2/ADCY9/PDE3B/IGF1R/KRAS/PRKACA/AKT2/MAPK1/ADCY7/RPS6KA3/CDC25B/PIK3CA/PRKACB/CDC16/CDC27/ANAPC16/ARAF/RAF1/MAD1L1/ANAPC13/ADCY6/MAPK8/FZR1/ANAPC10/MAD2L2/PIK3CD/ANAPC7/AKT3/MAPK10/CPEB2/PIK3R2/ANAPC2/CPEB3	0.370854314636495
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	48/3000	144/9376	1.04177777777778	RBPJ/ITPR1/VLDLR/PRKCA/PIK3R1/ATXN1/RB1CC1/ATXN2L/ATXN10/WIPI2/AKT2/PLCB1/PIK3CA/CIC/ITPR2/PSMC2/ULK2/PUM2/ATXN2/ATXN1L/SP1/PIK3C3/PLCB2/ULK1/KAT5/GRIN2D/ATG14/PRKCB/MAPK8/OMA1/MYOD1/PIK3R4/ATP2A2/ATG2B/AMBRA1/OPA1/PIK3CD/PSMC6/AKT3/ATG2A/MAPK10/TBP/ATXN3/RYR1/PIK3R2/ERN1/MTOR/ATP2A3	0.346537944467504
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	12/3000	34/9376	1.10305882352941	POLR3GL/POLR2C/POLR3D/POLR2J3/CRCP/POLR2B/POLR2M/POLR3E/POLR2K/POLR2A/POLR3A/POLR3C	0.412930363856023
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	11/3000	31/9376	1.10898924731183	ALDH9A1/ALDH3B1/ALDH3A2/DPYD/CSAD/ACADS/HIBCH/MLYCD/SMOX/ABAT/ALDH2	0.416914460539059
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	11/3000	31/9376	1.10898924731183	TMEM208/SEC62/SEC63/OXA1L/SPCS1/SGTA/BAG6/SEC61A1/SRP54/IMMP2L/SEC61A2	0.416914460539059
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	8/3000	22/9376	1.13648484848485	AOC1/ALDH9A1/ALDH3B1/HNMT/ALDH3A2/ASPA/MAOA/ALDH2	0.439611668180362
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	52/3000	157/9376	1.03514225053079	TNFRSF1A/IL6R/IRS1/SDHD/MAPK14/MLXIP/PIK3R1/JUN/UQCRC2/FAS/AKT2/SOCS3/NFKB1/PIK3CA/BID/NR1H3/COX7A1/NDUFB5/BCL2L11/PRKAA1/NDUFS1/UQCRB/ADIPOR1/CASP7/GSK3A/IKBKB/NDUFS4/MAPK8/DDIT3/RELA/PPARA/FOS/EIF2AK3/MAP3K11/PRKAG2/BAX/GSK3B/PIK3CD/SREBF1/PRKAG1/CASP3/AKT3/IL6/MAPK10/NDUFB10/ITCH/RXRA/PRKAB1/PIK3R2/ERN1/ATF4/LEPR	0.304585763704012
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	156/3000	480/9376	1.01573333333333	WNT2/TNFRSF1A/FZD2/CSF1/CCS/GPX7/WNT2B/CALM2/PRNP/WNT5B/CAPN2/UBB/ITPR1/SDHD/MAPK14/PRKCA/CAMK2D/OPTN/FZD1/GPX8/ATXN1/FZD7/CAT/CYBB/APC/RB1CC1/ACTR10/UQCRC2/ATXN2L/FAS/KRAS/UBA7/WIPI2/MAPK1/GPR37/UBE2L6/PLCB1/LRP5/NFKB1/FUS/TUBB2A/BID/TNFRSF1B/HIP1/BCL2/RAB5A/PINK1/ITPR2/PSMC2/IFT57/ULK2/PPP3CB/LRP6/CAMK2A/COX7A1/PSEN1/ATXN2/DVL3/TUBA1A/SPG11/ATXN1L/NDUFB5/BDNF/BCL2L1/DVL2/FZD4/NDUFS1/KIF5B/C9orf72/LRRK2/SQSTM1/PSEN2/PIK3C3/ATF6/PPP3CC/KLC1/UQCRB/DCTN6/DLG4/CSNK2A1/CASP7/PLCB2/SIGMAR1/ULK1/ARAF/CDK5/RAF1/DERL1/FZD6/TRAP1/GRIN2D/RYR2/ATG14/PRKCB/MAP1LC3B/CSNK2A2/PTGS2/NDUFS4/MAPK8/DDIT3/WDR41/RELA/HTRA2/DNAL4/HTT/EIF2AK3/MAP2K7/PIK3R4/MFN2/DKK2/BAX/STX1A/ATP2A2/CSNK2B/FIG4/ATG2B/AMBRA1/DCTN3/GSK3B/MT-ND3/TUBA3D/KLC4/ZFYVE1/NEFM/WNT11/MT-ND4L/PPP3R1/PSMC6/FADD/UBE2J2/DCTN4/TUBA4A/UBE2G2/CASP3/APAF1/WNT3/CACNA1C/RAB1A/IL6/ATG2A/MAPK10/DNAL1/NDUFB10/ATXN3/TOMM40L/RYR1/GPX1/DNAH10/MT-ND2/ERN1/PLCG1/DNALI1/MTOR/ATF4/ALS2/ATP2A3	0.242725881428888
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	20/3000	59/9376	1.05943502824859	ENPP1/NME3/NME4/DCTD/TYMP/TK2/DPYD/ENTPD4/NT5C2/RRM2B/UCK1/NT5C3A/ASMTL/NME7/CANT1/AK9/CDADC1/ENTPD1/CMPK2/CTPS2	0.314125029870514
Organismal Systems	Digestive system	hsa04970	Salivary secretion	31/3000	93/9376	1.04177777777778	ATP1B1/ATP2B1/LYZ/CALM2/ADCY3/ADRB3/ITPR1/PRKG1/ATP1A1/SLC4A2/PRKCA/ADCY9/VAMP2/BST1/GUCY1A2/PRKACA/ADCY7/PLCB1/KCNMA1/ATP1A2/PRKACB/ITPR2/PLCB2/PRKCB/ADCY6/SLC12A2/ATP2B4/CD38/SLC9A1/ATP1B3/ADRB2	0.277724853214587
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	11/3000	32/9376	1.07433333333333	GCK/GLA/PFKM/HK3/GLB1/G6PC3/GALM/B4GALT2/GALK1/GALT/GANC	0.288911144010988
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	28/3000	85/9376	1.02952156862745	ENPP1/NME3/NME4/IMPDH1/DCTD/TYMP/AMPD2/TK2/LACC1/ENTPD4/AK1/ENTPD2/NT5C2/HPRT1/RRM2B/GMPR2/UCK1/NT5C3A/AMPD3/ASMTL/NME7/CANT1/AK3/AK9/GMPR/ENTPD1/CMPK2/CTPS2	0.187538213324161
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	17/3000	51/9376	1.04177777777778	ENPP2/PLD3/LPCAT2/CHPT1/CEPT1/PLA2G7/PLD1/PAFAH1B1/TMEM86A/PLA2G2A/PLA2G4A/PLD4/AGPS/PLA2G4C/PAFAH2/TMEM86B/PLD2	0.205200358253375
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	26/3000	79/9376	1.02859071729958	SLC18A3/ATP6V0D1/AP2M1/SLC1A3/ATP6V1G1/STX2/VAMP2/ATP6V1C1/CLTC/TCIRG1/NAPA/ATP6V0A1/ATP6V0B/AP2A1/SLC6A2/ATP6V1B2/ATP6V1D/DNM1/AP2B1/ATP6V1H/AP2S1/STX1A/AP2A2/STXBP1/ATP6V0A2/ATP6V0E1	0.175040801331126
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	6/3000	17/9376	1.10305882352941	CYP27A1/HSD3B7/HSD17B4/ACOX2/CYP46A1/AMACR	0.291720553475914
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	6/3000	17/9376	1.10305882352941	FMO1/GGT5/CSAD/ADO/FMO4/GGT7	0.291720553475914
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/3000	17/9376	1.10305882352941	NRP2/PCDH7/TFRC/MYH10/LAMP2/LAMP1	0.291720553475914
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	29/3000	89/9376	1.0183670411985	GLUL/GABARAPL2/ADCY3/SLC38A2/PRKCA/GLS/GNAI1/GNAI2/TRAK2/GNG11/ADCY9/GABARAP/GABARAPL1/GNB4/PRKACA/ADCY7/PRKACB/GABBR1/PRKCB/ADCY6/GNB2/GNGT2/ABAT/GNB3/CACNA1C/SRC/GPHN/GNG12/GNGT1	0.119417669670939
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	66/3000	205/9376	1.00620487804878	CD36/TGFBR1/TGFBR2/CTSD/PDK4/TNNI3/COL1A2/COL3A1/COL1A1/IRS1/NCF2/SDHD/MAPK14/PRKCA/CAMK2D/PIK3R1/SMAD3/MMP9/CYBB/GFPT2/UQCRC2/AKT2/TGFB3/PDK2/PLCB1/NFKB1/REN/PIK3CA/PDHB/CAMK2A/RAC2/COX7A1/TGFB2/PTEN/NDUFB5/SP1/NDUFS1/UQCRB/PLCB2/PRKCD/MPC2/RYR2/NOS3/PRKCB/NDUFS4/MAPK8/RELA/PPARA/MPC1/ATP2A2/GSK3B/MT-ND3/NCF4/MT-ND4L/PIK3CD/AKT3/GSR/MAPK10/NDUFB10/PIK3R2/CYBA/MT-ND2/TBC1D4/MTOR/ATP2A3/GFPT1	0.0616132255548775
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	33/3000	102/9376	1.01113725490196	ATP1B1/ATP2B1/ADCY3/ITPR1/ATP1A1/SLC4A2/PRKCA/ADCY9/CPA1/BST1/RAP1A/ADCY7/TRPC1/PLCB1/KCNMA1/ATP1A2/ITPR2/PLA2G2A/PLCB2/RYR2/PRKCB/ADCY6/RAB3D/SLC12A2/ATP2A2/ATP2B4/CD38/RAP1B/SLC9A1/TPCN2/KCNQ1/ATP1B3/ATP2A3	0.0775741116812116
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	17/3000	52/9376	1.02174358974359	HSD17B2/HSD3B2/ADCY3/ADCY9/ALOX5/IGF1R/PRKACA/ADCY7/PRKACB/BMP6/ACOT2/PTGS2/ADCY6/PLA2G4A/SCARB1/PLA2G4C/HSD17B7	0.107845963794604
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	124/3000	388/9376	0.998817869415807	WNT2/TNFRSF1A/APOE/FZD2/SLC39A13/CSF1/MME/WNT2B/CALM2/LRP1/WNT5B/CAPN2/IRS1/ITPR1/SDHD/RTN3/LPL/FZD1/PIK3R1/FZD7/CYBB/APC/ADAM10/RB1CC1/UQCRC2/FAS/KRAS/WIPI2/AKT2/MAPK1/SLC39A7/RTN4/BACE1/APH1A/PLCB1/LRP5/NFKB1/TUBB2A/PIK3CA/BID/ITPR2/PSMC2/ULK2/PPP3CB/LRP6/SLC39A6/SLC11A2/COX7A1/PSEN1/DVL3/TUBA1A/NDUFB5/DVL2/FZD4/NDUFS1/KIF5B/PSEN2/PIK3C3/ATF6/PPP3CC/KLC1/UQCRB/CSNK2A1/CASP7/PLCB2/ULK1/ARAF/CDK5/RAF1/APBB1/SLC39A9/SLC39A4/FZD6/GRIN2D/ATG14/NCSTN/IKBKG/CSNK2A2/IKBKB/PTGS2/NDUFS4/MAPK8/DDIT3/RELA/EIF2AK3/MAP2K7/PIK3R4/DKK2/ATP2A2/CSNK2B/APH1B/ATG2B/AMBRA1/GSK3B/MT-ND3/TUBA3D/KLC4/WNT11/MT-ND4L/SLC39A11/PPP3R1/PIK3CD/PSMC6/FADD/TUBA4A/CASP3/APAF1/AKT3/WNT3/CACNA1C/IL6/SLC39A14/ATG2A/MAPK10/NDUFB10/SLC39A2/PIK3R2/MT-ND2/ERN1/IDE/MTOR/ATF4/ATP2A3/CHUK	-0.0163125515033331
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/3000	37/9376	1.01362162162162	VCAM1/APOL1/IL18/PRKCA/FAS/ICAM1/PLCB1/IL10/PLCB2/PRKCB/KNG1/IL6	0.0569444756230999
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	16/3000	50/9376	1.00010666666667	AOC1/CKB/ALDH9A1/P4HA2/OAT/SAT2/ALDH3A2/NOS3/SMOX/PYCR2/P4HA1/PYCR1/L3HYPDH/MAOA/ALDH2/P4HA3	0.000518726137332809
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/3000	28/9376	1.00457142857143	B3GALT2/B3GALNT1/B4GALT4/FUT4/B4GALT2/B4GALT3/ST3GAL3/ST3GAL4/A4GALT	0.0166166592269264
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/3000	28/9376	1.00457142857143	ATP6V0D1/ATP6V1G1/ATP6V1C1/TCIRG1/ATP6V0A1/ATP6V1B2/ATP6V1D/ATP6V0A2/ATP6V0E1	0.0166166592269264
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	94/3000	298/9376	0.985843400447427	PRLR/IL6ST/TNFRSF1A/TGFBR1/TGFBR2/CSF1/BMP5/CXCL14/GDF6/EPOR/LIFR/ACVR2A/IL6R/TNFSF13B/CNTFR/IL11RA/IL18/IFNGR2/CXCL16/OSMR/IL1R1/TNFRSF14/BMPR2/CXCR4/IL34/TNFSF12/IL4R/CD4/LTBR/TNFRSF12A/CCL18/FAS/BMPR1A/CTF1/OSM/IL10RB/IFNAR1/TGFB3/IL17RC/TNFRSF1B/TNFSF15/IFNGR1/ACVR1B/TNFRSF11B/CXCL3/ACVRL1/IL10/TGFB2/BMP4/TNFRSF21/CXCL9/CSH2/CLCF1/ACVR1/BMP6/IL2RG/CSH1/EDA/CCL7/IL11/CXCL2/IL1RN/RELT/CD40/IL13RA1/IL27RA/IL7R/CXCL10/IL16/CCL23/GHR/XCL1/CCR5/IL1RL1/IL18R1/TNFSF14/IL12RB1/TNFRSF10D/TNFRSF10B/CCL28/CCL20/PF4/TNFRSF10A/IL6/CCL26/IL17RE/CCL5/TSLP/CXCL1/TNFSF9/CCR10/CCL3/LIF/LEPR	-0.170350770236003
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	42/3000	134/9376	0.979582089552239	CALM2/ADCY3/ITPR1/CALD1/PRKG1/PRKCA/GNA13/ADCY9/MYH10/ROCK1/PTGIR/GUCY1A2/ROCK2/ADORA2B/PRKACA/MAPK1/ADCY7/PLCB1/KCNMA1/PRKACB/ITPR2/PLA2G2A/ARHGEF11/ARHGEF12/NPR2/PLCB2/PPP1R12A/ARAF/RAF1/PPP1R12B/PRKCD/PRKCB/ADCY6/PLA2G4A/RAMP2/GNA11/MYLK/PLA2G4C/CACNA1C/MYLK3/MYL9/PPP1R12C	-0.163287456116262
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/3000	32/9376	0.976666666666667	ACSS1/ACSS3/ACADS/HIBCH/MLYCD/SUCLA2/ECHDC1/MCEE/ABAT/ACACB	-0.0906895967747494
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/3000	13/9376	0.961641025641026	RAD50/LIG4/POLL/POLM	-0.0949299522295079
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/3000	23/9376	0.951188405797102	MME/CTSA/ENPEP/ANPEP/ATP6AP2/REN/LNPEP	-0.16076205692782
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	70/3000	227/9376	0.963759177679883	HGF/GSTT1/AHR/VEGFA/FOXO3/ABL1/NCF2/SDHD/MAPK14/PIK3R1/CAT/JUN/NFE2L2/UQCRC2/GSTM3/PDPK1/KRAS/AKT2/MAPK1/PLD1/EPHX1/PTPN1/NFKB1/PIK3CA/EPHX2/PTPRJ/SOS1/AKR1A1/COX7A1/MGST2/PTEN/NDUFB5/KEAP1/NDUFS1/NFKBIA/MAP2K4/PRKD2/UQCRB/HIF1A/PRKD1/ARAF/RAF1/PRKCD/IKBKG/IKBKB/NDUFS4/SOS2/MAPK8/GSTO1/RELA/FOS/MAP2K7/AKR1C1/MT-ND3/ABL2/MT-ND4L/PIK3CD/SLC26A2/NQO1/GSTM2/AKT3/SOD2/SRC/MAPK10/NDUFB10/PIK3R2/CYBA/MT-ND2/PLD2/CHUK	-0.379137087558835
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	16/3000	54/9376	0.926024691358025	SDS/PHGDH/IL4I1/AHCYL1/SDSL/TST/LACC1/MAT2B/MTR/APIP/GCLM/DNMT3A/MAT2A/BCAT1/MRI1/AHCYL2	-0.373939400803767
NA	NA	hsa04081	Hormone signaling	67/3000	219/9376	0.956152207001522	PRLR/SLC16A10/SLC40A1/EPOR/ADCY3/IGF2/IRS1/ADRB3/THRA/SMAD5/PRKG1/HAMP/PIK3R1/GNAI1/GNAI2/GNA13/GNG11/ADCY9/STAT3/GNB4/IGF1R/APPL1/PTH1R/BMPR1A/SMAD4/PRKACA/ADCY7/PLCB1/STK11/PIK3CA/SSTR1/PRKACB/STAT5A/GNA15/JAK2/CSH2/ADRA2A/ACVR1/NPR2/CSH1/ADIPOR1/GNA14/PLCB2/SMAD9/ADCY6/POMC/GHR/RAMP2/GNB2/GNA11/GNGT2/VIPR2/STAT5B/PIK3CD/OPRL1/GIP/GNB3/DRD4/UCN/SRC/MC1R/GPER1/PIK3R2/ADRB2/GNG12/LEPR/GNGT1	-0.450365693159673
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/3000	31/9376	0.907354838709678	GLUL/ACSS1/CAT/HYI/GRHPR/ACO2/AFMID/SHMT2/MCEE	-0.354393744278269
NA	NA	hsa04981	Folate transport and metabolism	9/3000	31/9376	0.907354838709678	MTHFR/SLCO2B1/ABCC3/MTR/ABCC4/MTHFS/SHMT2/SLC46A1/ABCC5	-0.354393744278269
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/3000	28/9376	0.892952380952381	ELOVL2/PPT1/ACAA2/HADHB/ACOT2/HSD17B12/THEM4/MBLAC2	-0.389106770230529
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	13/3000	45/9376	0.902874074074074	ABCA1/ABCC3/ABCD4/ABCA8/ABCG1/ABCC4/ABCD3/ABCA2/ABCA5/ABCB7/ABCC5/ABCC9/ABCB10	-0.447970531013079
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	10/3000	35/9376	0.892952380952381	FBP1/PFKM/HK3/PFKFB3/HSD17B14/GMPPA/ENOSF1/PMM2/FPGT/PFKFB2	-0.435197567920368
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/3000	18/9376	0.868148148148148	ACSL3/ACSL1/ACSF3/ACACB/MCAT	-0.384063537095277
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	12/3000	42/9376	0.892952380952381	AOC1/INMT/ALDH9A1/IL4I1/CAT/HAAO/ALDH3A2/TDO2/AFMID/DLST/MAOA/ALDH2	-0.476913779214575
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	17/3000	59/9376	0.900519774011299	GPX7/GSTT1/ANPEP/GPX8/GSTM3/GGT5/MGST2/GCLM/PGD/LANCL1/RRM2B/TXNDC12/GSTO1/GGT7/GSTM2/GSR/GPX1	-0.52577124771483
Cellular Processes	Cell motility	hsa04814	Motor proteins	58/3000	194/9376	0.934378006872852	TNNT1/TNNI3/TNNT3/DYNLT3/KIF1B/MYH10/MYO9A/ACTR10/CAPZA2/DYNC1LI2/MYO1D/TUBB2A/DYNC2H1/MYO1C/KIFC3/MYL3/MYO5A/HOOK3/TUBA1A/MYO1F/KIFAP3/KIF3B/KIF5B/KIF13A/KIF26A/KLC1/DCTN6/DYNC1H1/STARD9/MYO15B/KIF26B/TUBG2/MYO1G/DNAL4/DYNC2LI1/DCTN3/TUBA3D/MYO9B/KLC4/DCTN4/TUBA4A/TUBD1/DYNLT1/TNNT2/DYNLRB1/KIF7/KIF13B/KIF16B/DNAL1/MYL9/DNAH10/KIF1C/DNALI1/MYO10/TUBE1/MYO18A/KIF27/KIFC2	-0.633510400395804
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	7/3000	26/9376	0.841435897435897	LMBRD1/ABCD4/TCN2/SLC19A3/BTD/SCARB1/SLC46A1	-0.555338590675401
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	25/3000	87/9376	0.898084291187739	ATP1B1/TNNI3/ATP1A1/SLC8A1/CACNA2D1/UQCRC2/ATP1A2/MYL3/COX7A1/CACNB4/UQCRB/HRC/CACNA2D4/ASPH/RYR2/ATP2A2/SLC9A6/SLC9A1/CACNB2/TNNT2/CACNA1C/CACNB3/CACNB1/ATP1B3/ATP2A3	-0.655071017937639
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	16/3000	57/9376	0.877286549707602	ELOVL2/PPT1/ACAA2/ACSL3/HADHB/CPT1A/SCD5/ACADM/HSD17B4/ACADS/ACSL1/ACSF3/HSD17B12/FADS1/FADS2/MCAT	-0.637407325740637
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	13/3000	47/9376	0.86445390070922	ALDH9A1/ACSS1/ME2/ALDH3A2/PDHB/AKR1A1/ACYP2/ME3/GRHPR/HAGH/ME1/ACACB/ALDH2	-0.638984785996178
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/3000	23/9376	0.815304347826087	POLD4/MLH3/RFC1/MSH6/MSH3/POLD2	-0.608299184527356
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/3000	23/9376	0.815304347826087	ATP1B1/ATP1A1/GLS/ATP1A2/AQP1/ATP1B3	-0.608299184527356
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/3000	44/9376	0.852363636363636	MPG/POLD4/PARG/OGG1/RFC1/MBD4/NTHL1/PARP3/POLD2/XRCC1/POLL/POLG	-0.673293503878006
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/3000	78/9376	0.881504273504273	PIK3R1/WASL/BCAR1/FN1/SHC2/WASF2/CLTC/PIK3CA/RHOG/CAV2/ILK/ELMO1/GAB1/SHC1/DNM1/CRK/MAD2L2/ELMO2/PIK3CD/DOCK1/SRC/PIK3R2	-0.720820832525665
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	33/3000	115/9376	0.896834782608696	ITPR1/PRKCA/GNAI1/GNAI2/GNG11/GNB4/ALOX5/KRAS/PRKACA/MAPK1/DUSP1/TRPC1/PLCB1/PRKACB/ITPR2/PTGS1/PLCB2/ARAF/RAF1/KCNJ5/KCND2/PRKCB/PTGS2/PLA2G4A/GNB2/GNGT2/CASP3/GNB3/PLA2G4C/CACNA1C/MAOA/GNG12/GNGT1	-0.763528736697001
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/3000	27/9376	0.810271604938272	ELOVL2/SCD5/HSD17B4/ACOT2/HSD17B12/FADS1/FADS2	-0.677179412879583
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/3000	17/9376	0.735372549019608	GLUL/CPS1/CA14/CA5B	-0.749060233963267
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/3000	39/9376	0.801367521367521	MTHFR/AHCYL1/MAT2B/MTR/MTHFS/MAT2A/SHMT2/ALDH1L2/SARDH/AHCYL2	-0.85261112963104
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	109/3000	368/9376	0.925710144927536	TNFRSF1A/CCS/GPX7/CASP1/PFN2/SDHD/MAPK14/OPTN/GPX8/CAT/RB1CC1/ACTR10/UQCRC2/ATXN2L/ANXA11/WIPI2/NUP214/FUS/TUBB2A/BID/TNFRSF1B/TPR/SETX/BCL2/RAB5A/PINK1/PSMC2/ULK2/PPP3CB/ANG/COX7A1/ATXN2/RANBP2/TUBA1A/SPG11/NDUFB5/BCL2L1/POM121/MATR3/NDUFS1/KIF5B/C9orf72/SQSTM1/PIK3C3/ATF6/PPP3CC/KLC1/UQCRB/DCTN6/UBQLN2/SIGMAR1/POM121C/ULK1/DERL1/NRG2/GRIN2D/ATG14/MAP1LC3B/NDUFS4/SEC13/DDIT3/WDR41/NXT1/DNAL4/NUP93/EIF2AK3/PIK3R4/BAX/FIG4/UBQLN4/ATG2B/AMBRA1/DCTN3/MT-ND3/TUBA3D/NUP35/KLC4/NEFM/MT-ND4L/RAE1/PPP3R1/NUP62/PSMC6/DCTN4/NUP188/TUBA4A/NUP54/NUP133/CASP3/APAF1/RAB1A/ATG2A/NXF1/DNAL1/NDUFB10/NUP98/NUP153/TOMM40L/GPX1/DNAH10/MT-ND2/NUP160/ERN1/HDAC6/DNALI1/MTOR/ATF4/ALS2/NUP85	-0.997266758373956
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	56/3000	195/9376	0.897531623931624	CASP1/FCGR3A/ITGB2/NCF2/MAPK14/PRKCA/FPR3/PIK3R1/CYBB/C5AR1/FCGR1A/AQP9/AKT2/MAPK1/FCGR2A/PLCB1/SYK/NFKB1/PIK3CA/ITGAM/SIGLEC9/HDAC7/RAC2/TLR2/ITGAL/HDAC3/SELPLG/TLR4/TLR7/HDAC9/PLCB2/ATG7/RAF1/CLCN3/FPR1/CLCN5/PRKCB/MAP3K7/TLR8/RELA/HDAC4/NCF4/PIK3CD/PLCG2/CLCN4/AKT3/CLEC7A/SRC/HDAC10/C3/HDAC11/PIK3R2/CYBA/HDAC6/PLCG1/MTOR	-0.991823232172169
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/3000	43/9376	0.799503875968992	ALDH9A1/ACAA2/ACSL3/ALDH3A2/HADHB/CPT1A/ACADM/ACADS/ACSL1/CYP2U1/ALDH2	-0.903861082801917
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/3000	36/9376	0.781333333333333	ENPP1/GCK/HK3/G6PC3/GYG1/GANC/PGM2L1/GYG2/PYGB	-0.901638625530423
Organismal Systems	Sensory system	hsa04744	Phototransduction	7/3000	29/9376	0.754390804597701	CALM2/RCVRN/PDE6B/RGS9/PDE6G/SLC24A1/GNGT1	-0.908614391630412
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	43/3000	154/9376	0.872658008658009	NME3/NME4/HSD17B6/GUSB/GGCX/HAAO/ALDH3A2/RDH11/UROD/NADK2/TDO2/MAT2B/AKR1A1/VKORC1L1/PANK3/COQ7/GCLM/AK1/MOCS2/QPRT/AFMID/COQ5/PNPO/GMPPA/MAT2A/EARS2/NME7/COQ4/SHMT2/AK3/NMNAT1/BCAT1/NADK/NQO1/PMM2/AK9/ALDH2/UGDH/GPHN/PANK1/LIPT1/CMPK2/CTPS2	-1.09292799347241
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	16/3000	63/9376	0.79373544973545	LTA4H/PTGIS/ALOX5/EPHX2/TBXAS1/GGT5/PTGS1/PTGES/PLA2G2A/PTGS2/PLA2G4A/CYP2U1/PLA2G4C/LTC4S/CBR3/PTGR2	-1.12673602144287
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/3000	19/9376	0.657964912280702	PDHB/OGDH/DLST/LIPT1	-1.02364945042966
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	17/3000	67/9376	0.792995024875622	FBP1/ALDH9A1/ACSS1/ALDH3B1/GCK/MINPP1/PFKM/ADPGK/ALDH3A2/PDHB/AKR1A1/HK3/G6PC3/GALM/ENO3/ALDH2/ENO2	-1.16637655359654
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	31/3000	116/9376	0.835218390804598	FBP1/SDS/PHGDH/SDHD/ACSS1/GCK/H6PD/CAT/SDSL/ME2/PFKM/ESD/ADPGK/PDHB/HK3/ME3/ACADS/HIBCH/PGD/ACO2/SUCLA2/ME1/OGDH/SHMT2/MCEE/PRPS1/ENO3/DLST/CPS1/ENO2/IDNK	-1.22491048556733
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/3000	31/9376	0.705720430107527	FBP1/H6PD/PFKM/PGD/PRPS1/RBKS/IDNK	-1.1257019490956
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	7/3000	31/9376	0.705720430107527	ALDH9A1/GUSB/ALDH3A2/AKR1A1/HSD17B14/ALDH2/UGDH	-1.1257019490956
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	37/3000	138/9376	0.837951690821256	CALM2/ADCY3/ITPR1/MAPK14/CAMK2D/ADCY9/IGF1R/PPP2CB/PRKACA/MAPK1/ADCY7/RPS6KA3/PRKACB/ITPR2/PPP3CB/CAMK2A/YWHAH/PPP2R5E/SLK/FBXW11/PPP3CC/CDC16/CDC27/ANAPC16/MAD1L1/ANAPC13/ADCY6/ANAPC10/MAD2L2/PPP2R5A/BTRC/PPP3R1/ANAPC7/PPP2R5B/CPEB2/ANAPC2/CPEB3	-1.31542829562474
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/3000	16/9376	0.586	ALDH3B1/IL4I1/MAOA	-1.13682736587451
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/3000	37/9376	0.675747747747748	GLUL/GLS/IL4I1/GFPT2/ASPA/ABAT/CPS1/GFPT1	-1.35551955464723
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/3000	41/9376	0.686048780487805	POLD4/ATM/RAD50/NBN/UIMC1/POLD2/PALB2/RAD51B/TOP3B	-1.38187593239262
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	76/3000	275/9376	0.863728484848485	CREB3L1/C7/PRNP/NCF2/ITPR1/SDHD/MAPK14/HSPA1A/PIK3R1/CYBB/FYN/UQCRC2/PRKACA/C1QB/MAPK1/C1QA/CREB1/ATF2/TUBB2A/PIK3CA/HSPA1B/PRKACB/C1QC/ITPR2/PSMC2/PPP3CB/RAC2/COX7A1/ATF6B/TUBA1A/HSPA6/NDUFB5/CAV2/NDUFS1/KIF5B/PPP3CC/KLC1/UQCRB/CSNK2A1/CREB3/PRKCD/LAMC1/NCAM2/GRIN2D/RYR2/CSNK2A2/NDUFS4/MAPK8/DDIT3/EIF2AK3/BAX/CSNK2B/CREB5/GSK3B/MT-ND3/TUBA3D/NCF4/KLC4/MT-ND4L/PPP3R1/PIK3CD/PSMC6/TUBA4A/CASP3/APAF1/CACNA1C/IL6/NOTCH1/MAPK10/NDUFB10/CCL5/RYR1/PIK3R2/CYBA/MT-ND2/ATF4	-1.57325451144695
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/3000	30/9376	0.625066666666667	SDHD/PDHB/ACO2/SUCLA2/OGDH/DLST	-1.41082745759071
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/3000	27/9376	0.578765432098765	ACADS/HMGCL/ABAT/HMGCLL1/AACS	-1.50347225191641
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/3000	23/9376	0.543536231884058	GLUL/GLS/NOS3/CPS1	-1.50337343972643
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	38/3000	149/9376	0.797064876957494	ADCY3/ITPR1/MAPK14/PRKCA/GNAI1/GNAI2/GNG11/ADCY9/GNB4/PRKACA/MAPK1/ADCY7/PLCB1/PRKACB/ITPR2/NDUFB5/NDUFS1/NAPEPLD/PLCB2/KCNJ5/PRKCB/PTGS2/ADCY6/NDUFS4/MAPK8/ABHD6/GNB2/GNGT2/MT-ND3/MT-ND4L/GNB3/CACNA1C/DAGLB/MAPK10/NDUFB10/MT-ND2/GNG12/GNGT1	-1.71274301259021
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	19/3000	82/9376	0.724162601626016	GSTT1/NME3/NME4/IMPDH1/GUSB/TYMP/GSTM3/CES2/TK2/DPYD/MGST2/HPRT1/RRM2B/GSTO1/UCK1/NME7/GSTM2/CDADC1/NAT1	-1.72080179935126
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	84/3000	308/9376	0.852363636363636	CREB3L1/GPX7/CREBBP/ITPR1/SDHD/AP2M1/GPX8/SLC1A3/RB1CC1/ACTR10/UQCRC2/WIPI2/CREB1/PLCB1/CLTC/POLR2C/TUBB2A/HIP1/PSMC2/IFT57/ULK2/COX7A1/AP2A1/POLR2J3/TUBA1A/NDUFB5/BDNF/SP1/NDUFS1/KIF5B/PIK3C3/KLC1/POLR2B/UQCRB/DCTN6/DLG4/SIN3A/PLCB2/BBC3/ULK1/CREB3/REST/ATG14/NDUFS4/MAPK8/AP2B1/DNAL4/HTT/MAP2K7/PIK3R4/AP2S1/BAX/STX1A/CREB5/ATG2B/AMBRA1/DCTN3/MT-ND3/AP2A2/TUBA3D/KLC4/MT-ND4L/PSMC6/DCTN4/POLR2K/POLR2A/EP300/TUBA4A/CASP3/APAF1/SOD2/ATG2A/NRF1/MAPK10/DNAL1/NDUFB10/TBP/GPX1/DNAH10/MT-ND2/ERN1/TAF4/DNALI1/MTOR	-1.80711193268504
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	17/3000	75/9376	0.708408888888889	GLUL/SDS/PHGDH/SDSL/PFKM/MAT2B/MTR/ACO2/MAT2A/SHMT2/PYCR2/PRPS1/BCAT1/PYCR1/ENO3/CPS1/ENO2	-1.73905053227249
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/3000	41/9376	0.609821138211382	SDS/PHGDH/SDSL/GRHPR/SHMT2/MAOA/SARDH/SRR	-1.71739666841171
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	62/3000	235/9376	0.824556028368794	CREB3L1/ADCY3/ADRB3/SDHD/MAPK14/PRKG1/TSC2/ADCY9/SMARCD3/FGFR1/ACSL3/UQCRC2/KRAS/FRS2/PRKACA/ADCY7/SMARCC2/RPS6KA3/CREB1/ATF2/PRKACB/CPT1A/SOS1/COX7A1/ARID1B/SLC25A20/NDUFB5/PRKAA1/NDUFS1/UQCRB/ACSL1/CREB3/RPS6KB1/NDUFAF3/RHEB/SMARCE1/ARID1A/LIPE/ADCY6/NDUFS4/SOS2/MLST8/COA5/KDM3B/PNPLA2/TSC1/PRKAG2/KDM3A/CREB5/SMARCD2/MT-ND3/SLC25A29/MT-ND4L/AKT1S1/PRKAG1/COX18/NDUFB10/ZNF516/PRKAB1/MT-ND2/NDUFAF5/MTOR	-1.86830440687453
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	62/3000	238/9376	0.814162464985994	RPS4Y1/IL6ST/TNFRSF1A/C7/IL6R/CFD/CASP1/C1R/MAPK14/NRP1/PRKCA/PIK3R1/C3AR1/CYBB/C5AR1/JUN/STAT3/C1S/C2/C1QB/MAPK1/C1QA/IFNAR1/FCGR2A/SYK/TAB2/NFKB1/PIK3CA/C1QC/HBEGF/TLR2/IFIH1/NFKBIA/ADAR/TLR4/TLR7/CXCL10/MX2/TLR3/PRKCB/MAP3K7/IRAK4/IKBKG/IKBKB/TLR8/MAPK8/RELA/FOS/IRAK1/IKBKE/PIK3CD/PLCG2/NLRP3/TRAF6/IL6/TYK2/OAS2/C3/MAPK10/PIK3R2/PLCG1/CHUK	-1.99190420899612
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	8/3000	43/9376	0.581457364341085	CD36/ABCA1/AGPAT2/PLA2G2A/SLC27A1/AGPAT1/DGAT1/SCARB1	-1.88684146236627
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/3000	26/9376	0.480820512820513	PLA2G2A/PLA2G4A/FADS2/PLA2G4C	-1.81832079301351
Organismal Systems	Digestive system	hsa04976	Bile secretion	20/3000	90/9376	0.694518518518519	ATP1B1/ADCY3/ATP1A1/SLC4A2/ADCY9/AQP9/PRKACA/ADCY7/EPHX1/ABCC3/ATP1A2/PRKACB/NCEH1/ABCC4/ADCY6/SCARB1/AQP1/SLC9A1/RXRA/ATP1B3	-1.99739479831385
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	86/3000	323/9376	0.83213209494324	CCND2/PDGFRA/ZEB2/MARCKS/TIMP3/VIM/CD44/VEGFA/NOTCH2/SOCS1/CREBBP/IRS1/ABL1/CDK6/FSCN1/PDGFA/CDKN1A/PRKCA/GLS/UBE2I/PIK3R1/THBS1/BMPR2/PDGFRB/MMP9/DICER1/APC/CYP24A1/STAT3/ROCK1/MMP16/KRAS/EFNA5/ATM/MAPK1/ZFPM2/CDC25B/NFKB1/CCND1/PLAU/PIK3CA/ST14/DDIT4/BCL2/SOS1/MAPK7/TGFB2/TNXB/MYC/PTEN/RECK/BCL2L11/FOXP1/CDKN1B/BCL2L2/MDM4/DNMT3A/RAF1/BMF/SHC1/EFNA2/FGFR3/PRKCB/SIRT1/MIR29A/IKBKB/PTGS2/SOS2/SLC45A3/CRK/HDAC4/ZEB1/IGF2BP1/PIK3CD/PLCG2/RASSF1/EP300/CASP3/WNT3/NOTCH1/BMI1/MIR145/PIK3R2/PLCG1/MTOR/E2F1	-2.10593412932735
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/3000	23/9376	0.407652173913043	PCYOX1/ZMPSTE24/GGPS1	-1.95091056732596
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/3000	37/9376	0.506810810810811	ALDH3B1/IL4I1/FAHD1/COMT/FAH/MAOA	-2.06175156978239
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/3000	33/9376	0.473535353535354	PDHB/ACO2/OGDH/BCAT1/DLST	-2.07804581997124
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	12/3000	66/9376	0.568242424242424	HSD17B2/HSD3B2/HSD17B11/HSD17B6/COMT/HSD11B2/HSD11B1/HSD17B12/HSD11B1L/AKR1C1/HSD17B7/SRD5A1	-2.41439990433301
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/3000	26/9376	0.360615384615385	GCK/HES1/HHEX	-2.23931486045954
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/3000	36/9376	0.434074074074074	GUSB/AKR1A1/CRYL1/DHDH/UGDH	-2.33350917989581
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/3000	15/9376	0.208355555555556	AK1	-2.10468345283099
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/3000	46/9376	0.475594202898551	FTL/GUSB/FTH1/BLVRA/UROD/HMOX2/EARS2	-2.44555643524501
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	65/3000	268/9376	0.758009950248756	SLC39A13/CALM2/UBB/ITPR1/SDHD/CAMK2D/GNAI1/GNAI2/NFE2L2/UQCRC2/UBA7/PRKACA/DUSP1/SLC39A7/GPR37/UBE2L6/TUBB2A/PRKACB/PINK1/ITPR2/PSMC2/CAMK2A/SLC39A6/SLC11A2/COX7A1/TUBA1A/NDUFB5/BCL2L1/KEAP1/NDUFS1/KIF5B/LRRK2/ATF6/KLC1/UQCRB/SLC39A9/SLC39A4/TRAP1/NDUFS4/MAPK8/DDIT3/HTRA2/EIF2AK3/MFN2/BAX/MT-ND3/TUBA3D/KLC4/MT-ND4L/SLC39A11/PSMC6/UBE2J2/TUBA4A/UBE2G2/CASP3/APAF1/MAOA/SLC39A14/MAPK10/NDUFB10/SLC39A2/MT-ND2/ERN1/PLCG1/ATF4	-2.75692852082226
NA	NA	hsa04519	Cadherin signaling	103/3000	404/9376	0.796805280528053	CDH11/GJA1/PCDH10/WNT2/DES/PDGFRA/YAP1/PCDH18/FZD2/VIM/PRICKLE1/WNT2B/WNT5B/RRAS/ENAH/CREBBP/RYK/PCDH7/LHFPL2/AMOTL1/MAPK14/FZD1/FZD7/PDGFRB/MPDZ/FGFR1/ARHGAP35/APC/ADAM10/DAAM1/ROCK1/IGF1R/DCHS1/NCKAP1L/KRAS/ROCK2/TAOK1/MAPK1/MRAS/APH1A/MYO1D/LRP5/NFKB1/LATS2/ABI2/TAOK2/MYO1C/RERE/PKP1/TJP1/LRP6/RAC2/YWHAH/ATN1/PSEN1/DVL3/SHOC2/DVL2/MYO1F/FZD4/NFKBIA/PSEN2/FAT4/EVL/TCF7L1/VAV1/RAF1/VANGL1/WTIP/NF2/AJUBA/LATS1/NCKAP1/FZD6/NCSTN/IKBKG/PCDHGC3/IKBKB/MAPK8/RELA/CDH18/MYO1G/PRICKLE2/APH1B/PCDHAC2/GSK3B/CDH7/SAV1/WNT11/EP300/MOB1A/AMOTL2/TMC8/WNT3/MOB1B/PCDHGA3/MAPK10/CDH8/SCN1B/DAAM2/PCDHGA10/FAT1/CHUK	-2.86372017396491
Human Diseases	Substance dependence	hsa05034	Alcoholism	43/3000	191/9376	0.70360907504363	CREB3L1/CALM2/GNAI1/GNAI2/GNG11/GNB4/KRAS/ADORA2B/PRKACA/MAPK1/SHC2/CREB1/SLC29A3/ATF2/PRKACB/SOS1/PKIA/HDAC7/ATF6B/BDNF/HDAC3/HDAC9/CREB3/ARAF/RAF1/SHC1/CAMKK2/GRIN2D/SOS2/GNB2/CREB5/HDAC4/GNGT2/CAMKK1/GNB3/MAOA/HDAC10/HDAC11/NTRK2/HDAC6/ATF4/GNG12/GNGT1	-2.83866482794916
NA	NA	hsa04082	Neuroactive ligand signaling	45/3000	199/9376	0.706733668341709	SLC18A3/ADCY3/PRKCA/SLC1A3/GNAI1/GNAI2/GNG11/ADCY9/GNB4/OGFR/P2RY1/ADORA2B/PRKACA/ADCY7/PLCB1/PRKACB/P2RY11/P2RX4/ADRA2A/SLC6A2/GABBR1/CHRM2/TAC3/CHAT/PLCB2/HRH2/P2RX6/SLC17A9/GRIN2D/PRKCB/ADCY6/POMC/OGFRL1/GNB2/GNA11/GNGT2/OPRL1/ADORA1/P2RX1/GNB3/DRD4/HRH1/ADRB2/GNG12/GNGT1	-2.86820699434156
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/3000	30/9376	0.312533333333333	PLA2G2A/PLA2G4A/PLA2G4C	-2.58685148340602
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/3000	36/9376	0.347259259259259	POLD4/RNASEH2B/RFC1/POLD2	-2.69147681848716
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/3000	46/9376	0.407652173913043	PSMB8/PSMB9/PSMC2/PSMF1/PSMB10/PSMC6	-2.76240279187856
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	11/3000	70/9376	0.49112380952381	GSTT1/SULT1A1/GSTM3/EPHX1/MGST2/HSD11B1/PTGS2/GSTO1/HSD11B1L/GSTM2/NAT1	-2.9312424311856
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/3000	28/9376	0.223238095238095	MOCS2/GPHN	-2.82344734697526
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	12/3000	79/9376	0.47473417721519	GSTT1/ALDH3B1/GSTM3/EPHX1/MGST2/HSD11B1/GSTO1/HSD11B1L/DHDH/AKR1C1/GSTM2/CBR3	-3.21583224263713
Organismal Systems	Sensory system	hsa04742	Taste transduction	13/3000	86/9376	0.472434108527132	P2RY1/PRKACA/PLCB1/PRKACB/GABBR1/PLCB2/ENTPD2/ADCY6/PKD2L1/GNB3/CACNA1C/TAS2R14/PDE1A	-3.37124402302287
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	24/3000	138/9376	0.543536231884058	ATP6V0D1/SDHD/ATP6V1G1/UQCRC2/ATP6V1C1/TCIRG1/ATP6AP1/ATP6V0A1/ATP6V0B/COX7A1/NDUFB5/NDUFS1/ATP6V1B2/UQCRB/ATP6V1D/NDUFS4/ATP6V1H/MT-ND3/MT-ND4L/LHPP/ATP6V0A2/NDUFB10/MT-ND2/ATP6V0E1	-3.70534786540038
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/3000	68/9376	0.367686274509804	CYP2W1/HSD17B6/DHRS4L2/DHRS4/RDH11/DGAT1/ALDH1A1/RDH10	-3.5894754674397
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/3000	73/9376	0.385315068493151	GSTT1/ALDH3B1/FMO1/GSTM3/MGST2/GSTO1/FMO4/GSTM2/MAOA	-3.61638448884483
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	24/3000	143/9376	0.524531468531469	HLA-DRA/C7/HLA-DPA1/HLA-DPB1/FCGR3A/HLA-DMA/HLA-DMB/C1R/HLA-DQA2/HLA-DQA1/HLA-DRB1/HLA-DQB1/CD86/FCGR1A/C1S/C2/C1QB/C1QA/FCGR2A/HLA-DOA/C1QC/IL10/CD40/C3	-3.92998136519576
Genetic Information Processing	Transcription	hsa03040	Spliceosome	46/3000	243/9376	0.591626886145405	HSPA1A/FUS/THOC2/HSPA1B/SLU7/PRPF38B/SF1/DDX42/HSPA6/SF3B1/WBP11/DHX38/PRPF6/PQBP1/CDC40/SF3B3/CCDC12/PRPF8/CDC5L/U2AF1L4/PPIE/SNRNP200/PLRG1/XAB2/SF3A1/DDX39B/U2SURP/SF3B4/SYF2/PRPF18/SF3B5/SART1/SRSF5/DHX15/THOC6/SRSF4/DHX8/USP39/CHERP/CRNKL1/SF3B2/GPKOW/SRSF10/AQR/BUD13/PCBP1	-4.42410739559316
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/3000	41/9376	0.0762276422764228	GRIN2D	-4.06604182054535
NA	NA	hsa04382	Cornified envelope formation	34/3000	217/9376	0.48968356374808	S100A4/S100A10/DST/PPL/CLDN11/PPP2CB/UGCG/EPHX2/PLEC/ST14/S100A16/PKP1/COL4A5/TJP1/PPP2R5E/CLDN23/SPTLC2/SLC27A1/KAZN/PPP2R2D/PPP2R3C/PPP2R5A/BLMH/PADI2/S100A6/CLDN15/KDSR/PPP2R5B/CLDN12/SPTLC1/LAMB3/TMEM79/COL7A1/CLDN1	-5.21695997848812
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	25/3000	183/9376	0.42695810564663	RPP25/XRN1/UTP14C/CSNK2A1/RIOK2/TBL3/SBDS/MPHOSPH10/CSNK2A2/NXT1/CSNK2B/RPP25L/WDR75/SNORD3B-1/NMD3/HEATR1/WDR36/REXO1/NXF1/SNORD3D/REXO2/DROSHA/SNORD3A/RCL1/NOL6	-5.36976648575196
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	69/3000	370/9376	0.582832432432432	PRLR/NR3C1/NPW/ADRB3/THRA/LPAR1/FPR3/GLP2R/C3AR1/PTGER2/CYSLTR2/C5AR1/LYPD6/PTGER4/PTGIR/PTH1R/EDNRB/OGFR/P2RY1/ADORA2B/PTAFR/PTGFR/PTGER1/NPY1R/SSTR1/PGRMC1/P2RY11/TBXA2R/P2RX7/P2RX4/BDKRB1/CSH2/ADRA2A/GPR35/TSPO/GABBR1/CSH1/CHRM2/TAC3/HRH2/P2RX6/LPAR6/FPR1/GRIN2D/POMC/GHR/KNG1/S1PR4/OGFRL1/S1PR3/UTS2/VIPR2/PTH2R/S1PR5/PGRMC2/OPRL1/ADORA1/GIP/P2RX1/NMUR1/DRD4/UCN/MC1R/LTB4R/C3/NPFFR2/HRH1/ADRB2/LEPR	-5.61587637895955
Genetic Information Processing	Translation	hsa03010	Ribosome	5/3000	222/9376	0.0703903903903904	RPS4Y1/MRPL10/MRPL28/MRPL43/MRPS6	-9.61487735876324
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	13/3000	449/9376	0.0904884929472903	CALM2/ADCY3/PRKG1/CAMK2D/RGS2/SLC8A1/ARRB2/PRKACA/PRKACB/CAMK2A/ARRB1/NCALD/PDE1A	-13.5472365008869