category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	162/2020	250/9376	3.00774653465347	ACP5/CTSH/CD68/LIPA/LAPTM5/CTSS/PPT1/ASAH1/DNASE2/LITAF/HEXB/CTSD/SCARB2/AP1S2/CTSA/SLC11A1/TPP1/LGMN/ATP6V0D1/CTSZ/LAMP2/SLC15A3/HEXA/CTSB/GNS/ATP6AP1/ATP6V0B/CTSC/ATP6V1F/PSAP/NPC2/ATP6V0E1/CD63/ACP2/LAMP1/TCIRG1/M6PR/RRAGD/IDS/CTSL/VAMP8/GAA/ATP6V1B2/DMXL2/MITF/GNPTG/IGF2R/BLOC1S2/FUCA1/GLA/ARL8A/GUSB/GM2A/MANBA/PLA2G15/CTBS/VPS13C/ATP6V1A/GNPTAB/GGA1/ARL8B/SLC17A5/MCOLN1/GLB1/CLN8/OSBPL1A/OSTM1/CLCN7/NAGLU/LAPTM4A/ATP6V1D/GGA2/BLOC1S1/SLC29A3/NAGPA/GALC/LAMTOR4/ATP6V1G1/ATP6V1C1/SUMF1/RAB7A/ATP6V0A1/BLOC1S6/TFEB/FUCA2/NAGA/GPR155/ARSA/VPS41/CTSO/TPCN1/NPC1/TLR7/GALNS/SLC11A2/ARSB/ATP6V1H/TLR8/SMPD1/SLC36A1/LAMTOR2/AP1B1/AP3S1/RRAGC/AP2S1/HGSNAT/AP3B1/FIG4/SLC15A4/SNAPIN/DTNBP1/SPG11/SLC2A6/SORT1/VPS18/CLN6/AGA/DMXL1/ROGDI/CTSK/LAMTOR3/SGSH/AP5Z1/ZFYVE26/TFE3/PLEKHM1/MAN2B1/SLC36A4/AP2B1/AP5B1/OSBP/VAMP7/CTNS/VPS11/LAMTOR1/VPS39/CTSF/VPS26B/WDR7/AP1G1/AP1M1/VPS16/OSBPL3/DNASE2B/MCOLN3/AP5M1/ATP6V0D2/TPCN2/TMEM175/GGA3/PIKFYVE/IDUA/OSBPL2/VPS13A/ARSG/ATP6V0A2/ABCA5/MCOLN2/MFSD8/ATP6V0C/ABCA2/OSBPL5	16.8608366049936
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	105/2020	181/9376	2.69263169410864	HLA-DPA1/HLA-DPB1/HLA-DMA/FCGR3A/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/LSP1/HLA-DQA1/CD74/CTSS/IL18/ITGB2/CTSD/FCER1G/ATP6V0D1/ITGAX/HLA-DQA2/LAMP2/STAT1/IFNGR2/ATP6AP1/ATP6V0B/LAMP1/TCIRG1/FCGR1A/CEBPB/C3/IFNGR1/IL10RA/IL10RB/HLA-DOA/JAK1/RHOA/BID/NFKB1/SYK/RIPK2/PLK3/SPHK1/CLEC7A/ITGAM/TNFRSF1A/TLR4/FCGR2A/CIITA/BAX/TRADD/CORO1A/TLR1/IRAK1/RAB5C/TLR2/RAB7A/IL10/ATP6V0A1/CARD9/MYD88/CAMK2D/MRC2/VDR/MAPK1/TGFB1/ATP6V1H/IL1B/JAK2/BCL10/CASP8/CYCS/CREBBP/RAB5A/CLEC4E/FCGR2B/IRAK4/RFX5/MALT1/BCL2/SRC/EP300/CREB1/CASP10/CR1/CAMP/PPP3CB/TLR6/CYP27B1/ATP6V0D2/PIK3C3/NOD2/TRAF6/PPP3CC/MAPK8/CASP9/ATP6V0A2/SPHK2/IL23A/IL6/FCGR3B/IL1A/ATP6V0C/HLA-DQB2/TGFB2/IRAK2/CR1L	12.0494258084425
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	85/2020	142/9376	2.77841305257286	ACP5/FCGR3A/TREM2/NCF2/SPI1/LILRB4/TYROBP/STAT1/IFNGR2/JUNB/JUN/NFKBIA/CYBA/OSCAR/FCGR1A/SIRPA/SQSTM1/MITF/IFNGR1/JAK1/BTK/FOS/LCP2/SOCS3/NFKB1/SYK/JUND/IFNAR1/LILRB1/TGFBR1/TGFBR2/TNFRSF1A/FOSB/STAT2/FOSL2/RELB/CSF1R/FCGR2A/LILRB3/GRB2/CYLD/LILRB2/SIRPB1/NCF4/NFKB2/NCF1/LILRA2/MAPK1/ITPR1/PIK3R1/TAB2/TGFB1/IFNAR2/ATP2A2/IL1B/IKBKG/BLNK/CSF1/FCGR2B/PLCG2/CTSK/IKBKB/RAC1/CREB1/SOCS1/PIK3CA/MAP2K1/LILRA6/PPP3CB/PIK3CD/CHUK/TEC1/TRAF6/PPP3CC/MAP2K7/MAPK8/LILRA4/NFATC1/LILRA1/ITGB3/FCGR3B/IL1A/ATP2A3/TGFB2/FOSL1	11.1898003256589
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	85/2020	155/9376	2.54538486106675	OLR1/MSR1/HLA-DPA1/HLA-DPB1/HLA-DMA/FCGR3A/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/NCF2/CTSS/HLA-F/HLA-B/ITGB2/HLA-A/ATP6V0D1/HLA-DQA2/LAMP2/CD36/HLA-E/ATP6AP1/ATP6V0B/HLA-C/ATP6V1F/CYBA/ATP6V0E1/LAMP1/TCIRG1/M6PR/CTSL/FCGR1A/ATP6V1B2/C3/TAP1/HLA-DOA/MARCO/ATP6V1A/TFRC/CLEC7A/ITGAV/ITGAM/STX7/TUBA1A/CYBB/ATP6V1D/TLR4/FCGR2A/CORO1A/RILP/RAB5C/ATP6V1G1/ATP6V1C1/TLR2/RAB7A/STX12/ATP6V0A1/NCF4/NCF1/MRC2/ATP6V1H/DYNC1H1/SCARB1/CANX/ITGB5/VAMP3/RAB5A/ACTB/DYNC1LI1/THBS3/TUBB2A/FCGR2B/RAC1/TLR6/ATP6V0D2/PIK3C3/HGS/PIKFYVE/TUBA4A/ATP6V0A2/ITGB3/FCGR3B/ATP6V0C/HLA-DQB2	10.1660900941694
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	53/2020	78/9376	3.15389692815435	HLA-DPA1/HLA-DPB1/HLA-DMA/FCGR3A/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/NCF2/ITGB2/HLA-DQA2/STAT1/IFNGR2/JUN/NFKBIA/CYBA/FCGR1A/C3/PTPN6/IFNGR1/HLA-DOA/JAK1/FOS/NFKB1/ITGAM/CYBB/TLR4/FCGR2A/IRAK1/TLR2/IL10/NCF4/MYD88/NCF1/MAPK1/TAB2/TGFB1/IL1B/JAK2/ITGA4/PTGS2/IRAK4/CR1/PRKCB/NFKBIB/TRAF6/ELK1/FCGR3B/IL1A/HLA-DQB2/TGFB2/CR1L	10.0096273633547
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	114/2020	248/9376	2.13363142765889	IL18/LY96/PTPRC/JUN/NFKBIA/S100A10/M6PR/PYCARD/FLNA/AHNAK/STX10/RHOG/RRAS/NCKAP1L/ARL8A/ARPC1B/FOS/RHOA/ARPC4/BIRC3/ANXA2/NFKB1/PLEKHM2/RIPK2/ARL8B/CASP1/ACTR3/ARPC3/ABI1/RHOB/CYTH1/TUBA1A/RALA/TNFRSF1A/TLR4/CASP4/BAX/TRADD/RILP/IRAK1/ACTR2/RAB5C/RAB9A/TLR2/RAB7A/TNFSF10/MYD88/VPS41/KPNA3/MAPK1/TLR5/KPNA4/ARPC2/CYFIP1/TAB2/DYNC1H1/IL1B/PAK1/PKN1/DYNLT3/BAK1/IKBKG/CASP8/CYCS/RAB5A/ACTB/BIRC2/GCC2/DYNC1LI1/ACTR1A/CYTH4/FHOD1/VPS18/NLRC4/TUBB2A/TNFRSF10B/IRAK4/KIF5B/MAP2K3/BCL2/PLEKHM1/IKBKB/TNFRSF10A/RIPK3/RAC1/VPS11/VPS39/PIK3CA/CASP7/MAP2K1/VPS16/TLR6/DCTN4/EXOC4/ACTR1B/NLRP3/MLKL/RIPK1/PIK3CD/CHUK/PIK3C3/PIK3CG/KPNA1/RHOH/TRAF6/MAP2K7/TUBA4A/MAPK8/AHNAK2/EXOC2/MYL5/CYTH3/FYCO1/IL6	9.48091743890696
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	67/2020	119/9376	2.6133288959148	CXCL2/JUNB/JUN/NFKBIA/CXCL3/CEBPB/TNFAIP3/FOS/IRF1/ICAM1/SOCS3/BIRC3/CFLAR/NFKB1/MMP9/MAP3K8/TNFRSF1B/CCL20/TNFRSF1A/TRADD/ADAM17/CYLD/XIAP/RHBDF2/TRAF3/MAPK1/PIK3R1/TAB2/BCL3/CREB3L2/IL1B/MAP3K5/CXCL10/IKBKG/CASP8/BIRC2/CREB5/CSF1/PTGS2/IL15/CREB3/CCL5/MAP2K3/IKBKB/RIPK3/TRAF1/ATF6B/CREB1/CASP10/RPS6KA4/PIK3CA/CASP7/MAP2K1/FAS/ITCH/MLKL/RIPK1/PIK3CD/CHUK/NOD2/MAP2K7/MAPK8/JAG1/FRMD8/IL6/CXCL5/EDN1	9.2811485505949
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	57/2020	95/9376	2.7849504950495	ACP5/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/IL18/ITGB2/TNFSF13B/ATP6V0D1/HLA-DQA2/ATP6AP1/CXCL2/JUN/ATP6V0B/ATP6V1F/ATP6V0E1/TCIRG1/CD86/CTSL/CXCL3/ATP6V1B2/HLA-DOA/FOS/ICAM1/ATP6V1A/VEGFA/CCL20/ATP6V1D/TLR4/ATP6V1G1/ATP6V1C1/TLR2/ATP6V0A1/ITGAL/CCL3/TGFB1/ATP6V1H/IL1B/CSF1/IL15/CCL5/CTSK/CD80/ATP6V0D2/ATP6V0A2/IL23A/IL6/TNFSF13/IL1A/CXCL5/ATP6V0C/HLA-DQB2/TGFB2	9.16286007523663
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	63/2020	112/9376	2.61089108910891	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/LY96/HLA-DQA2/STAT1/IFNGR2/HSPA1B/HSPA1A/GNAI2/NFKBIA/ALOX5/IFNGR1/IL10RA/IL10RB/HLA-DOA/JAK1/BIRC3/NFKB1/CD40/TNFRSF1A/TLR4/STAT3/CIITA/IRAK1/PIK3R5/TLR2/IL10/XIAP/MYD88/MAPK1/HSPA6/BCL2L1/PPIF/TAB2/TGFB1/JAK2/ITGA6/IKBKG/CASP8/CYCS/BIRC2/CCR5/IRAK4/MAP2K3/BCL2/IKBKB/SOCS1/LAMB3/NFKBIB/CHUK/PIK3CG/PIK3R6/TRAF6/MAPK8/CASP9/HLA-DQB2/TGFB2	8.98703390085662
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	83/2020	173/9376	2.22688719739026	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/IL18/HLA-DQA2/STAT1/IFNGR2/DNAJB1/NFKBIA/PYCARD/IFNGR1/HLA-DOA/JAK1/ICAM1/SOCS3/BID/NFKB1/OAS1/CASP1/IFNAR1/TNFRSF1A/STAT2/TLR4/IFIH1/CIITA/BAX/TRADD/OAS2/TNFSF10/MX2/DNAJC3/MYD88/TRAF3/MAPK1/TLR7/PIK3R1/IRF7/IFNAR2/MX1/IL1B/ADAR/JAK2/CALCOCO2/BAK1/CXCL10/IKBKG/CASP8/CYCS/CREBBP/ACTB/PML/HNRNPUL1/TNFRSF10B/CCL5/IRAK4/IKBKE/TICAM1/IKBKB/TNFRSF10A/CDK6/EP300/PIK3CA/MAP2K1/FAS/RSAD2/RNASEL/PRKCB/NLRP3/NFKBIB/PIK3CD/CHUK/KPNA1/CASP9/NLRX1/KPNA5/IL6/IL1A/HLA-DQB2	8.53499827740867
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	87/2020	187/9376	2.15945359241807	TXNIP/IL18/GPSM3/STAT1/CTSB/CXCL2/JUN/NFKBIA/CYBA/PYCARD/GABARAP/CXCL3/GABARAPL1/NAMPT/IFI16/CARD16/TNFAIP3/JAK1/GBP2/RHOA/TRPV2/BIRC3/P2RX7/NFKB1/OAS1/RIPK2/CASP1/GBP4/IFNAR1/GBP1/GBP5/CYBB/STAT2/MAP1LC3B/TLR4/GABARAPL2/CASP4/OAS2/GBP3/XIAP/CARD9/MYD88/TANK/TRAF3/MAPK1/ITPR1/BCL2L1/CARD6/TAB2/IRF7/IFNAR2/PLCB2/IL1B/PSTPIP1/PRKCD/PKN1/IKBKG/CASP8/SHARPIN/BIRC2/NLRC4/CCL5/IRAK4/IKBKE/TICAM1/BCL2/AIM2/IKBKB/TRPM2/RIPK3/PKN2/TRPM7/CAMP/RNASEL/NLRP3/RIPK1/NFKBIB/CHUK/NEK7/MCU/NOD2/TRAF6/MAPK8/MFN2/NLRX1/NLRP12/IL6	8.39229053994952
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	92/2020	205/9376	2.08305240280126	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/CD44/HLA-F/HLA-B/HLA-A/HLA-DQA2/TAPBP/STAT1/HLA-E/GADD45B/VIM/JUN/NFKBIA/HLA-C/B2M/CD58/CDKN1A/TAP1/TNFAIP3/HLA-DOA/JAK1/NFKBIE/BTK/ICAM1/LYN/BID/NFKB1/OAS1/SYK/CD40/IFNAR1/STAT2/RELB/STAT3/TAPBPL/BAX/TRADD/IRAK1/OAS2/TLR2/ITGAL/MYD88/NFKB2/TRAF3/RUNX3/PIK3R1/TAB2/IRF7/IFNAR2/ENTPD1/NCOR2/GADD45G/BAK1/CXCL10/IKBKG/CASP8/CYCS/BLNK/POLK/CIR1/IRAK4/PLCG2/DDB2/MAP2K3/BCL2L11/IKBKE/BCL2/IKBKB/CDK6/RAC1/PIK3CA/USP7/FAS/RIPK1/NFKBIB/PIK3CD/CHUK/HES1/TRAF6/MAP2K7/MAPK8/CASP9/JAK3/IL6/HLA-DQB2	8.21596379193211
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	89/2020	196/9376	2.10765811275005	HLA-F/CLEC2B/HLA-B/HLA-A/ZFP36/STAT1/HLA-E/CXCL2/JUN/NFKBIA/HLA-C/CD86/CXCL3/GNB4/C3/IFNGR1/CDKN1A/HIF1A/JAK1/FOS/ICAM1/LYN/BID/NFKB1/SYK/VEGFA/IFNAR1/HCK/PREX1/TNFRSF1A/STAT2/MAP1LC3B/STAT3/BAX/TRADD/PIK3R5/ATG3/UBC/TRAF3/MAPK1/ITPR1/KRAS/PIK3R1/IRF7/IFNAR2/GNGT2/JAK2/BECN1/CCR1/BAK1/IKBKG/CASP8/CYCS/CREBBP/MAPKAPK2/PTGS2/NFATC3/CCR5/PLCG2/MICA/GNB1/IKBKE/TICAM1/MICB/IKBKB/CDK6/SRC/RAC1/EP300/CREB1/NRAS/PIK3CA/MAP2K1/FAS/GNG7/PPP3CB/PIK3CD/CHUK/PIK3C3/PIK3CG/PIK3R6/PPP3CC/ATG14/MAP2K7/MAPK8/CASP9/NFATC1/IL6/PDGFB	8.21207468532673
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	80/2020	169/9376	2.19719960161697	CTSD/LAMP2/CTSB/LAMP1/RRAGD/CTSL/SQSTM1/GABARAP/VAMP8/GABARAPL1/MRAS/HIF1A/RRAS/CFLAR/STX7/MAP1LC3B/PRKACB/ATG7/DAPK1/GABARAPL2/RAB7A/ATG3/TAX1BP1/UBC/DDIT4/VPS41/C9orf72/ERN1/TANK/MAPK1/SH3GLB1/MTMR14/ITPR1/KRAS/BCL2L1/PIK3R1/RB1CC1/RRAGC/BECN1/UVRAG/CALCOCO2/PRKCD/BIRC6/VMP1/IRS2/WDR41/NRBF2/ATG16L2/NBR1/VPS18/WDR45/PRKACA/RAB1A/MTMR3/ATG4C/BCL2/PLEKHM1/PRKAA1/ATG4B/VPS11/VPS39/NRAS/PIK3CA/EPG5/MAP2K1/EIF2AK3/VPS16/ATG2A/PIK3CD/PIK3C3/TP53INP2/TRAF6/ATG4A/ATG14/MAPK8/TSC2/ZFYVE1/AMBRA1/PIK3R4/ULK2	8.22983839004383
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	69/2020	137/9376	2.33773216737732	CTSH/CTSS/BCL2A1/CTSD/CTSZ/CTSB/GADD45B/JUN/NFKBIA/CTSC/CTSL/FOS/BIRC3/CFLAR/BID/MCL1/NFKB1/TUBA1A/TNFRSF1A/BAX/TRADD/TNFSF10/XIAP/ATM/CTSO/ERN1/PARP4/LMNA/MAPK1/ITPR1/KRAS/BCL2L1/PIK3R1/GADD45G/CAPN2/BAK1/MAP3K5/IKBKG/CASP8/CYCS/ACTB/SPTAN1/BIRC2/TNFRSF10B/CTSK/BCL2L11/CSF2RB/BCL2/IKBKB/TNFRSF10A/TRAF1/DDIT3/CASP10/CTSF/NRAS/PIK3CA/CASP7/MAP2K1/FAS/EIF2AK3/BBC3/RIPK1/PIK3CD/CHUK/PARP3/TUBA4A/MAPK8/CASP9/IL3RA	8.26527738111749
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	95/2020	216/9376	2.04143747708104	OLR1/NCF2/IL18/LY96/HSPA1B/CD36/HSPA1A/CXCL2/SOD2/JUN/NFKBIA/CYBA/ABCA1/PYCARD/NFE2L2/CXCL3/RAP1A/FOS/RHOA/ICAM1/LYN/BID/NFKB1/MMP9/CD40/CASP1/TNFRSF1A/CYBB/TLR4/STAT3/BAX/IRAK1/ABCG1/TLR2/TNFSF10/CCL3/NCF4/RAP1B/MYD88/NCF1/VAV1/ERN1/CAMK2D/TANK/TRAF3/MAPK1/HSPA6/ITPR1/KRAS/BCL2L1/PIK3R1/TAB2/IRF7/ATF6/PLCB2/IL1B/JAK2/POU2F2/MAP3K5/IKBKG/CASP8/CYCS/TNFRSF10B/NFATC3/CCL5/IRAK4/MAP2K3/ARHGEF1/IKBKE/TICAM1/BCL2/IKBKB/TNFRSF10A/RXRA/SRC/RAC1/DDIT3/NRAS/PIK3CA/CASP7/FAS/EIF2AK3/PPP3CB/TLR6/NLRP3/PIK3CD/CHUK/RXRB/TRAF6/PPP3CC/MAP2K7/MAPK8/CASP9/NFATC1/IL6	8.11433256955803
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	69/2020	138/9376	2.32079207920792	IL18/CD4/JUN/NFKBIA/FN1/PYCARD/SKAP2/RHOG/WIPF1/ARPC1B/FOS/LCP2/RHOA/ARPC4/NFKB1/WAS/CASP1/RPS6KA1/ACTR3/LIMK1/ARPC3/TLR4/GIT2/FCGR2A/IRAK1/ACTR2/ROCK1/IL10/RAC2/MYD88/VAV1/MAPK1/GNAQ/ARPC2/PIK3R1/TAB2/RPS6KA3/RPS6KA2/IL1B/PKN1/WIPF3/IKBKG/ACTB/PTK2B/NLRC4/ITGA4/LAT/NFATC3/IRAK4/MAP2K3/ARHGEF1/TICAM1/WASF2/IKBKB/BAIAP2/SRC/RAC1/WIPF2/PKN2/PIK3CA/MAP2K1/NLRP3/PIK3CD/CHUK/TRAF6/MAP2K7/MAPK8/NFATC1/IL6	8.19078417773346
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	52/2020	91/9376	2.65233380480905	LILRB4/JUN/CD81/NFKBIA/CD72/PTPN6/NFKBIE/BTK/FOS/LYN/RASGRP3/NFKB1/SYK/LILRB1/PIK3AP1/LILRB3/GRB2/LILRB2/DAPP1/RAC2/VAV1/LILRA2/MAPK1/KRAS/PIK3R1/CD22/SOS2/BCL10/IKBKG/INPP5D/BLNK/SOS1/NFATC3/FCGR2B/PLCG2/MALT1/IKBKB/INPPL1/RAC1/NRAS/PIK3CA/MAP2K1/LILRA6/PPP3CB/PRKCB/NFKBIB/PIK3CD/CHUK/PPP3CC/LILRA4/NFATC1/LILRA1	8.2998069859678
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	82/2020	180/9376	2.11449944994499	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/CD74/HLA-F/HLA-B/HLA-A/BST2/PILRA/HLA-DQA2/TAPBP/STAT1/IFNGR2/HLA-E/TNFRSF14/NFKBIA/HLA-C/B2M/C3/IFNGR1/TAP1/HLA-DOA/JAK1/SOCS3/BIRC3/BID/NFKB1/OAS1/SYK/SP100/IFNAR1/TNFRSF1A/STAT2/IFIH1/TAPBPL/BAX/TRADD/IRAK1/OAS2/TLR2/CARD9/MYD88/TRAF3/BCL2L1/PIK3R1/TAB2/IRF7/IFNAR2/IL1B/JAK2/ZC3HAV1/POU2F2/BAK1/TNFSF14/IKBKG/CASP8/CYCS/PML/BIRC2/CCL5/IRAK4/IKBKE/TICAM1/BCL2/IKBKB/SRC/PIK3CA/FAS/RNASEL/PIK3CD/CHUK/TRAF6/CASP9/TSC2/ITGB3/IL6/HLA-DQB2	7.91146830169699
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	87/2020	200/9376	2.01908910891089	IL18/JUN/NFKBIA/PYCARD/GNA13/PTPN6/NCKAP1L/WIPF1/ARPC1B/FOS/RHOA/MYO1F/ARPC4/NFKB1/CASP1/ACTR3/ARPC3/ABI1/CYTH1/TUBA1A/HCLS1/TNFRSF1A/TMBIM6/TLR4/CASP4/FCGR2A/BAX/TRADD/MYO5A/NCK1/IRAK1/ACTR2/ROCK1/MYO1E/TNFSF10/ARHGEF2/MYD88/MAPK1/TLR5/ARPC2/CYFIP1/TAB2/IL1B/PAK1/WIPF3/BAK1/TMED10/IKBKG/CASP8/CYCS/GNA12/ACTB/CYTH4/TUBB2A/TNFRSF10B/IRAK4/RAB1A/ARHGEF11/ARHGEF1/CLDN23/WASF2/IKBKB/TNFRSF10A/BAIAP2/MYO1G/PAK2/SRC/RAC1/WIPF2/CASP7/FAS/LPAR1/SEC24D/NLRP3/RIPK1/NFKBIB/CHUK/SEC24B/TRAF6/LPAR2/TUBA4A/MAPK8/CASP9/LPAR5/CYTH3/IL6/CLDN1	7.63380247378713
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	54/2020	105/9376	2.38710042432815	LSP1/FCER1G/STAT1/JUN/NFKBIA/PYCARD/MRAS/RRAS/IRF1/RHOA/NFKB1/SYK/CASP1/PLK3/CLEC7A/STAT2/RELB/CYLD/IL10/CARD9/NFKB2/MAPK1/ITPR1/KRAS/PIK3R1/BCL3/IL1B/PAK1/PRKCD/BCL10/IKBKG/CASP8/MAPKAPK2/CLEC4E/PTGS2/NFATC3/PLCG2/MALT1/IKBKE/IKBKB/SRC/NRAS/PIK3CA/PPP3CB/NLRP3/PIK3CD/CHUK/PPP3CC/MAPK8/NFATC1/CCL22/IL23A/IL6/CLEC4D	7.48996392973217
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	73/2020	163/9376	2.07874627953593	STAT1/ATP6AP1/JUN/NFKBIA/CDKN1A/JAK1/FOS/BID/NFKB1/MMP9/STAT5A/IFNAR1/TGFBR1/TGFBR2/STAT2/TLR4/IFIH1/STAT3/BAX/IRAK1/TLR2/GRB2/MYD88/TRAF3/MAPK1/KRAS/PIK3R1/TAB2/TGFB1/IRF7/STAT6/CREB3L2/JAK2/SOS2/IKBKG/CASP8/CYCS/CREBBP/PTK2B/CREB5/SOS1/NFATC3/CREB3/IRAK4/DDB2/MAP2K3/IKBKE/TICAM1/BCL2/IKBKB/SRC/ATF6B/EP300/CREB1/CASP10/NRAS/PIK3CA/MAP2K1/FAS/PRKCB/PIK3CD/CHUK/ARAF/TRAF6/MAP2K7/MAPK8/CASP9/NFATC1/JAK3/ELK1/IL6/STAT4/TGFB2	7.28036310588963
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	55/2020	109/9376	2.34208374965937	SPP1/LY96/STAT1/JUN/NFKBIA/CD86/JAK1/FOS/NFKB1/CD40/MAP3K8/IFNAR1/STAT2/TLR4/TLR1/IRAK1/TLR2/IRF5/CCL3/CXCL9/MYD88/TRAF3/MAPK1/TLR7/TLR5/PIK3R1/TAB2/IRF7/IFNAR2/TLR8/IL1B/TOLLIP/CXCL10/IKBKG/CASP8/CCL5/IRAK4/MAP2K3/CTSK/IKBKE/TICAM1/IKBKB/RAC1/PIK3CA/MAP2K1/TLR6/CD80/CXCL11/RIPK1/PIK3CD/CHUK/TRAF6/MAP2K7/MAPK8/IL6	7.3852252850516
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	55/2020	109/9376	2.34208374965937	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-DQA2/STAT1/CD4/IFNGR2/JUN/NFKBIA/IFNGR1/AHR/HIF1A/HLA-DOA/JAK1/NFKBIE/FOS/NFKB1/IL2RG/STAT5A/TGFBR1/TGFBR2/STAT3/IL6R/MAPK1/TGFB1/STAT6/IL27RA/IL1B/JAK2/IL4R/IKBKG/RARA/LAT/NFATC3/SMAD2/IKBKB/RXRA/IL12RB1/PPP3CB/NFKBIB/CHUK/RXRB/PPP3CC/MAPK8/NFATC1/IL23A/JAK3/IL21R/IL6/HLA-DQB2	7.3852252850516
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	91/2020	224/9376	1.88564356435644	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-F/HLA-B/ITGB2/SPI1/HLA-A/ZFP36/HLA-DQA2/CD4/HLA-E/TSPO/JUN/NFKBIA/HLA-C/B2M/CDKN1A/TLN1/HLA-DOA/JAK1/FOS/ICAM1/NFKB1/IL2RG/CD40/STAT5A/TGFBR1/TGFBR2/TNFRSF1A/PRKACB/RELB/BAX/XIAP/ADCY7/ATM/ITGAL/MMP7/NFKB2/MAPK1/KRAS/VAC14/BCL2L1/PIK3R1/TGFB1/ADCY3/LTBR/CREB3L2/CANX/IKBKG/CREBBP/MAP3K3/CREB5/NFATC3/IL15/CREB3/PRKACA/IL15RA/SMAD2/MAD1L1/IKBKB/ELK4/ATF6B/EP300/CREB1/NRAS/PIK3CA/MAP2K1/PPP3CB/PIK3CD/CHUK/CRTC2/POLB/PPP3CC/CRTC1/MAPK8/KAT2B/NFATC1/TLN2/JAK3/ELK1/IL6/CDKN2B/HLA-DQB2/TGFB2/FOSL1	7.03016368957474
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	70/2020	157/9376	2.06949612158668	LIPA/SGK1/DUSP2/HAVCR2/LRP1/CD36/NR1H3/ABCA1/ALOX5/PTGER4/SIRPA/CEBPB/C1QB/PTPN6/HIF1A/C1QA/PLA2G15/TMEM30A/CD47/CASP1/C1QC/SPHK1/ITGAV/ADAM10/MERTK/ADAM17/RAB5C/RAB7A/CPT1A/IL10/ADAM9/AXL/SIRPB1/VPS41/CAMK2D/MAPK1/NR1H2/TGFB1/ATP2A2/JAK2/GPR132/ITGB5/SIGLEC10/VPS8/RAB5A/MAPKAPK2/VPS18/PTGER2/PTGS2/NFATC3/RXRA/RAC1/CREB1/VPS11/VPS39/CASP7/MAP2K1/VPS16/ATP11B/TGFBRAP1/SIRT1/CH25H/SPHK2/NFATC1/ATP8A1/DUSP7/ITGB3/ANO5/SCARF1/ATP2A3	7.0815380880295
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	97/2020	250/9376	1.80093465346535	CXCR4/HLA-F/HLA-B/HLA-A/CHMP1B/HSPA1B/HLA-E/HSPA1A/HLA-C/ARRB2/IGF2R/RAB31/WIPF1/ARPC1B/RHOA/ARPC4/TFRC/IL2RG/ACTR3/SH3KBP1/ZFYVE16/ARPC3/ARAP1/CYTH1/TGFBR1/TGFBR2/ARFGAP3/AGAP3/PDCD6IP/GIT2/SMAP1/CAPZA2/ACTR2/RAB5C/SMAP2/CHMP3/RAB7A/RUFY1/ACAP2/SPG21/CBL/SMURF2/SNX1/HSPA6/SH3GLB1/EHD4/ARPC2/RAB22A/RAB11FIP1/CHMP4A/AP2S1/WIPF3/USP8/RAB10/CHMP4B/RAB5A/PML/ARF3/ARRB1/CYTH4/CAPZA1/IST1/ARFGEF1/CHMP5/ASAP1/CCR5/VPS37B/KIF5B/STAM2/ARAP2/PLD1/SMAD2/VPS28/PLD2/IQSEC2/FOLR3/AP2B1/SRC/IQSEC1/RNF41/WIPF2/VPS26B/ITCH/CAPZB/ARFGEF2/HGS/PSD3/TRAF6/VPS37C/CXCR2/ACAP1/CYTH3/ZFYVE27/AGAP2/ARAP3/GRK4/EHD1	6.72616193840784
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	90/2020	227/9376	1.8402756575217	CXCR4/HLA-F/HLA-B/HLA-A/TAPBP/HLA-E/GNAI2/NFKBIA/HLA-C/B2M/PTGER4/GNA13/GNB4/AKAP13/CDKN1A/IL10RA/TAP1/IL10RB/JAK1/RHOA/BID/NFKB1/VEGFA/ITGAV/TNFRSF1A/PRKACB/STAT3/TAPBPL/BAX/TRADD/IL6R/ROCK1/GRB2/ADCY7/CCL3/RAC2/MAPK1/ITPR1/KRAS/GNAQ/PIK3R1/ADCY3/PLCB2/CREB3L2/IL1B/GNGT2/SOS2/CCR1/BAK1/IKBKG/CASP8/CYCS/GNA12/PTK2B/PTGER2/CREB5/PTGS2/SOS1/NFATC3/CREB3/CCR5/CCL5/PRKACA/ARHGEF11/ARHGEF1/GNB1/IKBKB/CDK6/SRC/ATF6B/RAC1/CREB1/NRAS/PIK3CA/MAP2K1/FAS/GNG7/PPP3CB/PRKCB/RIPK1/PIK3CD/CHUK/PPP3CC/CXCR2/CASP9/TSC2/NFATC1/ELK1/ITGB3/IL6	6.71565473043731
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	79/2020	193/9376	1.89992304929975	CXCL16/CXCR4/STAT1/CXCL2/GNAI2/NFKBIA/ARRB2/CXCL3/GNB4/FGR/CCL18/DOCK2/RAP1A/RHOA/LYN/NFKB1/WAS/HCK/PREX1/CCL20/STAT2/PRKACB/STAT3/PIK3R5/ROCK1/GRB2/ADCY7/FOXO3/CCL3/CXCL9/RAC2/RAP1B/NCF1/VAV1/MAPK1/KRAS/GNAQ/PIK3R1/ADCY3/PLCB2/CCL7/GNGT2/JAK2/PAK1/PRKCD/SOS2/CCR1/CXCL10/IKBKG/PTK2B/CCL23/ARRB1/SOS1/TIAM1/CCR5/CCL5/PRKACA/PLCG2/GNB1/IKBKB/SRC/RAC1/NRAS/PIK3CA/MAP2K1/GNG7/CXCL11/PRKCB/NFKBIB/PIK3CD/CHUK/PIK3CG/PIK3R6/CXCR2/CCL22/JAK3/CXCL5/CCR2/GRK4	6.61960690521665
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	51/2020	105/9376	2.25448373408769	TNFSF13B/BCL2A1/LY96/GADD45B/CXCL2/NFKBIA/CXCL3/TNFAIP3/BTK/ICAM1/LYN/BIRC3/CFLAR/NFKB1/SYK/CD40/TNFRSF1A/TLR4/RELB/TRADD/IRAK1/CYLD/XIAP/ATM/MYD88/NFKB2/TRAF3/BCL2L1/TAB2/LTBR/IL1B/GADD45G/PLAU/BCL10/TNFSF14/IKBKG/BLNK/BIRC2/LAT/PTGS2/IRAK4/PLCG2/MALT1/TICAM1/BCL2/IKBKB/TRAF1/PRKCB/RIPK1/CHUK/TRAF6	6.77386997650411
Human Diseases	Infectious disease: viral	hsa05162	Measles	61/2020	136/9376	2.08188701223064	STAT1/MSN/HSPA1B/HSPA1A/JUN/NFKBIA/TNFAIP3/JAK1/FOS/BID/NFKB1/OAS1/IL2RG/STAT5A/IFNAR1/STAT2/TLR4/IFIH1/STAT3/BAX/TRADD/IRAK1/OAS2/RAB9A/TLR2/MX2/CD46/MYD88/TRAF3/HSPA6/TLR7/BCL2L1/PIK3R1/TAB2/IRF7/IFNAR2/MX1/IL1B/ADAR/BAK1/IKBKG/CASP8/CYCS/FCGR2B/IRAK4/IKBKE/BCL2/IKBKB/CDK6/PIK3CA/FAS/BBC3/NFKBIB/PIK3CD/CHUK/TRAF6/MAPK8/CASP9/JAK3/IL6/IL1A	6.65971798027155
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	37/2020	66/9376	2.602100210021	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/IL18/HLA-DQA2/STAT1/IFNGR2/JUN/IFNGR1/HLA-DOA/NFKB1/IL2RG/TLR4/STAT3/TLR2/IL10/TLR5/TGFB1/STAT6/IL1B/IL4R/SMAD2/IL12RB1/NOD2/NFATC1/IL23A/IL21R/IL6/IL1A/HLA-DQB2/STAT4/TGFB2	6.84427210480913
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	46/2020	93/9376	2.29583732566805	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-DQA2/STAT1/CD4/IFNGR2/JUN/NFKBIA/IFNGR1/NOTCH2/HLA-DOA/JAK1/NFKBIE/FOS/NFKB1/IL2RG/STAT5A/MAPK1/MAML2/RUNX3/STAT6/JAK2/IL4R/IKBKG/LAT/NFATC3/IKBKB/IL12RB1/NOTCH1/PPP3CB/NFKBIB/CHUK/PPP3CC/MAML3/MAPK8/NFATC1/JAG1/JAK3/HLA-DQB2/STAT4	6.58094478492688
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	107/2020	300/9376	1.65549834983498	MAP3K2/DUSP2/DUSP1/HSPA1B/GADD45B/HSPA1A/JUN/FLNA/ARRB2/HSPB1/MRAS/VEGFB/RRAS/TAOK3/RAP1A/FOS/DUSP10/EREG/RASGRP3/NFKB1/VEGFA/JUND/RPS6KA1/MAP3K8/MAPKAPK3/TGFBR1/TGFBR2/TNFRSF1A/PRKACB/STK4/RELB/CSF1R/TRADD/IRAK1/MAX/HGF/GRB2/AREG/RAC2/RAP1B/MYD88/NFKB2/TAOK1/MAPK1/HSPA6/KRAS/TAB2/TGFB1/RPS6KA3/NR4A1/DUSP3/RPS6KA2/IL1B/RAPGEF2/PTPN7/PAK1/GADD45G/MAP3K11/SOS2/MAP3K5/IKBKG/GNA12/MAPKAPK2/MAP3K3/ARRB1/CSF1/SOS1/NFATC3/PRKACA/CACNA2D4/IRAK4/PLA2G4C/MAP2K3/LAMTOR3/IKBKB/PAK2/ELK4/PPM1A/RAC1/DDIT3/NRAS/RPS6KA4/MAP2K1/MAP4K3/FAS/PPP3CB/PRKCB/PDGFC/CHUK/MAPK7/PLA2G4A/ARAF/TRAF6/PPP3CC/MAP2K7/RASA2/MAPK8/NFATC1/TAOK2/DUSP7/ELK1/PDGFB/FLT3LG/IL1A/MAP3K12/CACNA1A/TGFB2	6.04679783793609
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	46/2020	98/9376	2.17870276823601	FCGR3A/PTPRC/MARCKS/GSN/FCGR1A/ARPC1B/LYN/ARPC4/SYK/WAS/ACTR3/SPHK1/LIMK1/ARPC3/HCK/FCGR2A/ACTR2/RAC2/NCF1/VAV1/MAPK1/ARPC2/PIK3R1/VASP/PAK1/PRKCD/INPP5D/LAT/FCGR2B/CFL1/ASAP1/PLCG2/PLA2G4C/PLD1/WASF2/PLD2/INPPL1/RAC1/PIK3CA/MAP2K1/PRKCB/PIK3CD/PLA2G4A/SCIN/SPHK2/FCGR3B	6.14653869299537
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	57/2020	133/9376	1.98925035360679	SGK1/GADD45B/SOD2/HOMER3/GABARAP/GABARAPL1/CDKN1A/CAT/SGK3/PLK3/PRKAG2/TGFBR1/TGFBR2/STK4/GABARAPL2/STAT3/KLF2/PCK2/GRB2/IL10/TNFSF10/FOXO3/ATM/IL7R/BCL6/MAPK1/KRAS/PIK3R1/S1PR4/TGFB1/GADD45G/SOS2/IRS2/CREBBP/SOS1/BCL2L11/RBL2/IKBKB/PRKAA1/G6PC3/EP300/FBXO25/NRAS/PIK3CA/MAP2K1/USP7/PIK3CD/CHUK/ARAF/FOXO1/SIRT1/MAPK8/FBXO32/AGAP2/IL6/CDKN2B/TGFB2	6.02096386497882
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	81/2020	214/9376	1.756861293606	CXCR4/HLA-F/HLA-B/HLA-A/BST2/SAMHD1/AP1S2/TAPBP/CD4/HLA-E/JUN/GNAI2/NFKBIA/HLA-C/B2M/GNB4/TAP1/FOS/BID/NFKB1/LIMK1/APOBEC3C/TNFRSF1B/TNFRSF1A/TLR4/TAPBPL/BAX/TRADD/IRAK1/APOBEC3G/TLR2/ATM/RAC2/MYD88/MAPK1/ITPR1/KRAS/BCL2L1/GNAQ/PIK3R1/TAB2/AP1B1/GNGT2/PAK1/BAK1/IKBKG/CASP8/CYCS/PTK2B/NFATC3/CFL1/CCR5/IRAK4/PLCG2/MAP2K3/GNB1/BCL2/IKBKB/PAK2/RAC1/FBXW11/NRAS/PIK3CA/MAP2K1/AP1G1/FAS/AP1M1/GNG7/PPP3CB/APOBEC3A/PRKCB/RIPK1/PIK3CD/CHUK/TRAF6/PPP3CC/MAP2K7/MAPK8/CASP9/APOBEC3F/NFATC1	5.86905935018914
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	31/2020	56/9376	2.56944837340877	IL18/ITGB2/HSPA1B/HSPA1A/CXCL2/NFKBIA/PYCARD/CXCL3/C3/NFKB1/CASP1/ITGAM/TLR4/TLR2/CLK1/MYD88/NFKB2/HSPA6/TLR5/IL1B/SAR1B/CASP8/CYCS/NLRC4/RAB1A/CR1/CASP7/CLK4/CASP9/IL6/CR1L	6.172677030761
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	47/2020	103/9376	2.1180044218014	IFNGR2/JUN/GNAI2/NFKBIA/C1QB/C3/IFNGR1/C1QA/FOS/CFLAR/NFKB1/C1QC/SERPINE1/TGFBR1/TGFBR2/TNFRSF1A/TLR4/IRAK1/GNA15/TLR2/IL10/CCL3/MYD88/MAPK1/GNAQ/PIK3R1/TGFB1/PLCB2/IL1B/IKBKG/CASP8/CCL5/IRAK4/SMAD2/TICAM1/IKBKB/PIK3CA/FAS/TLR6/PIK3CD/CHUK/PPP2R2D/TRAF6/ACE/MAPK8/IL6/TGFB2	5.97850320397923
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	36/2020	71/9376	2.35347929159113	ATP6V0D1/ATP6AP1/CXCL2/JUN/ATP6V0B/NFKBIA/ATP6V1F/ATP6V0E1/TCIRG1/CXCL3/ATP6V1B2/HBEGF/LYN/ATP6V1A/NFKB1/ADAM10/ATP6V1D/CSK/ADAM17/ATP6V1G1/ATP6V1C1/ATP6V0A1/ATP6V1H/PAK1/IKBKG/CCL5/PLCG2/IKBKB/SRC/RAC1/ATP6V0D2/CHUK/CXCR2/MAPK8/ATP6V0A2/ATP6V0C	5.99878177910078
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	38/2020	77/9376	2.29065192233509	STAT1/GADD45B/CDKN1A/JAK1/NFKB1/VEGFA/TGFBR1/TGFBR2/RALA/STAT3/BAX/RAC2/MAPK1/KRAS/BCL2L1/PIK3R1/TGFB1/RALGDS/GADD45G/BAK1/IKBKG/POLK/ARHGEF6/DDB2/PLD1/SMAD2/IKBKB/PLD2/CDK6/RAC1/PIK3CA/MAP2K1/PIK3CD/CHUK/ARAF/MAPK8/CASP9/TGFB2	5.95904731791383
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	52/2020	120/9376	2.01135313531353	JUN/NFKBIA/ARHGDIB/NFKBIE/RAP1A/RHOA/NFKB1/RIPK2/RPS6KA1/BAX/IRAK1/GRB2/SH2B3/FOXO3/KIDINS220/MATK/RAP1B/RAPGEF1/CAMK2D/MAPK1/PSEN1/KRAS/PIK3R1/RPS6KA3/PSEN2/RPS6KA2/PRKCD/IRAK3/SOS2/MAP3K5/MAPKAPK2/SORT1/MAP3K3/SOS1/IRAK4/ARHGDIA/PLCG2/BCL2/IKBKB/RAC1/NRAS/PIK3CA/MAP2K1/NFKBIB/PIK3CD/MAPK7/TRAF6/PRDM4/MAP2K7/MAPK8/SH2B1/IRAK2	5.84281637653728
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	41/2020	90/9376	2.11449944994499	STAT1/CD4/IFNGR2/JUN/NFKBIA/PTPN6/IFNGR1/HIF1A/JAK1/NFKBIE/FOS/NFKB1/TLR4/STAT3/TLR2/MYD88/MAPK1/KRAS/PIK3R1/EML4/JAK2/IKBKG/BATF/MAP3K3/LAT/NFATC3/MAP2K3/TICAM1/IKBKB/NRAS/PIK3CA/MAP2K1/PPP3CB/NFKBIB/PIK3CD/CHUK/TRAF6/PPP3CC/NFATC1/BATF2/CD274	5.56707710197038
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	40/2020	87/9376	2.13406168203027	GADD45B/JUN/CDKN1A/FOS/RHOA/EREG/TGFBR1/TGFBR2/RALA/BAX/GRB2/AREG/RAC2/APC/MAPK1/KRAS/PIK3R1/TGFB1/RALGDS/GADD45G/SOS2/APPL1/BAK1/CYCS/POLK/SOS1/DDB2/SMAD2/BCL2L11/BCL2/RAC1/NRAS/PIK3CA/MAP2K1/BBC3/PIK3CD/ARAF/MAPK8/CASP9/TGFB2	5.56868028137056
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	89/2020	253/9376	1.63281023754549	CD44/IL18/JUN/NFKBIA/PYCARD/RRAGD/SQSTM1/C3/TLN1/ARPC1B/RHOA/CAST/ARPC4/NFKB1/UBE2D1/RIPK2/CASP1/ACTR3/CAPNS1/ARPC3/CYTH1/HCLS1/TNFRSF1A/HK3/MAP1LC3B/TLR4/FNBP1/CASP4/BAX/TRADD/ACTR2/ROCK1/FOXO3/ATM/UBC/ARHGEF2/MYD88/TNIP1/MAPK1/ITPR1/TLR5/BCL2L1/ARPC2/PIK3R1/TAB2/PLCB2/IL1B/UBE2D3/RRAGC/BECN1/CALCOCO2/PRKCD/CAPN2/BCL10/IKBKG/CYCS/ACTB/SHARPIN/UBE2D4/CYTH4/NLRC4/CCL5/PLCG2/MALT1/HK2/WASF2/BCL2/IKBKB/SRC/RAC1/FBXW11/DIAPH1/PIK3CA/U2AF1L4/NLRP3/RIPK1/NFKBIB/PIK3CD/CHUK/PIK3C3/FOXO1/TRAF6/ATG14/MAPK8/TECPR1/MYL5/CYTH3/TLN2/PIK3R4	5.34694088116215
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	34/2020	70/9376	2.25448373408769	CD36/NFKBIA/ACSL1/NFKBIE/SOCS3/NFKB1/PRKAG2/TNFRSF1B/TNFRSF1A/ACSL3/STAT3/TRADD/PCK2/CPT1A/JAK2/APPL1/IRS2/IKBKG/ACSL5/POMC/AGRP/ADIPOR1/IKBKB/RXRA/PRKAA1/G6PC3/ACSL6/ADIPOR2/NFKBIB/CHUK/RXRB/MAPK8/LEPR/ACACB	5.52043109006221
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	34/2020	70/9376	2.25448373408769	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-F/HLA-B/ITGB2/HLA-A/HLA-DQA2/HLA-E/HLA-C/CD86/HLA-DOA/ICAM1/BID/CD40/ITGAL/RAC2/SNTB1/ABL2/EIF4G3/CASP8/CYCS/ACTB/RAC1/EIF4G2/CD80/SNTB2/CASP9/HLA-DQB2	5.52043109006221
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	31/2020	62/9376	2.32079207920792	NOTCH2/NUMB/ATXN1/APH1B/LFNG/APH1A/ADAM17/PSENEN/PTCRA/TLE3/NCSTN/MFNG/PSEN1/MAML2/DTX3L/SPEN/PSEN2/NCOR2/CREBBP/RFNG/CIR1/DTX2/EP300/ITCH/NOTCH1/HES1/MAML3/NRARP/ATXN1L/KAT2B/JAG1	5.4676744246582
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	45/2020	105/9376	1.98925035360679	JUN/SQSTM1/GABARAP/GABARAPL1/MITF/MRAS/HIF1A/RRAS/BNIP3L/MAP1LC3B/GABARAPL2/RAB5C/RAB7A/TFEB/FOXO3/SMURF2/TAX1BP1/UBC/AMFR/KRAS/BCL2L1/PINK1/BECN1/CALCOCO2/USP8/RAB5A/NBR1/USP15/RHOT1/CCZ1/TFE3/SRC/ARIH1/NRAS/EIF2AK3/MON1B/TOMM40L/MUL1/CCZ1B/MAPK8/MFN2/NLRX1/AMBRA1/MON1A/USP30	5.34168207004801
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	48/2020	115/9376	1.93735686612139	SGK1/MAFB/NR4A2/GNAI2/ARRB2/GNA13/AKAP13/CDKN1A/HBEGF/FOS/RHOA/MEF2A/JUND/PRKACB/ADCY7/PDE4B/WNK1/VDR/MAPK1/ITPR1/GNAQ/ADCY3/PLCB2/PDE4A/CREB3L2/GNA12/STK39/ARRB1/MEF2D/CREB5/CREB3/PRKACA/RUNX2/ARHGEF11/ARHGEF1/PLD1/BCL2/RXRA/PLD2/ATF6B/CREB1/OXSR1/MAP2K1/PRKCB/CYP27B1/RXRB/ARAF/MMP17	5.29987230260858
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	43/2020	100/9376	1.99588118811881	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/CD9/HLA-DQB1/HLA-DRB1/HLA-DQA1/CD37/CD44/HLA-DQA2/CD4/CD36/ANPEP/FCGR1A/HLA-DOA/TFRC/ITGAM/CSF3R/CSF1R/IL6R/IL7R/CD33/IL1B/CD38/ITGA6/CD22/IL4R/CD59/ITGA4/CSF1/CD1D/CR1/IL7/IL3RA/ITGB3/IL6/FLT3LG/IL1A/ITGA3/HLA-DQB2/CR1L	5.24647516519989
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	65/2020	174/9376	1.7339251166496	HSPA1B/HSPA1A/DNAJB1/NFE2L2/HERPUD1/BCAP31/MAN1A1/PPP1R15A/UBE2D1/OS9/HSPH1/SEL1L/BAX/TRAM1/DERL1/FBXO6/BCAP29/DNAJC3/AMFR/ERN1/DNAJC5B/HSPA6/SSR1/SEC62/SIL1/DNAJC1/ATF6/UBE2D3/CANX/SEC31A/DNAJC5/RPN1/EDEM2/STUB1/DNAJB12/CAPN2/UBXN6/SEC63/SAR1B/EDEM1/BAK1/MAP3K5/STT3B/NGLY1/UBE2D4/SSR3/EDEM3/MAN1B1/UBE2J1/MAGT1/BCL2/ATXN3/ATF6B/DNAJB2/DDIT3/SEC23A/EIF2AK3/SYVN1/SEC24D/SEC24B/MAP2K7/UBQLN4/MAPK8/UBQLN2/MBTPS2	5.12065743211868
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	34/2020	73/9376	2.16183371761834	GADD45B/CDKN1A/STAT5A/STK4/STAT3/BAX/HGF/GRB2/FOXO3/RASSF5/MAPK1/KRAS/PIK3R1/EML4/GADD45G/SOS2/BAK1/POLK/SOS1/PLCG2/KIF5B/DDB2/RXRA/CDK6/NRAS/PIK3CA/MAP2K1/PRKCB/PIK3CD/RASSF1/RXRB/ARAF/CASP9/JAK3	5.22196982842279
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	50/2020	125/9376	1.85663366336634	ASAH1/CTSD/FCER1G/GNAI2/GNA13/RHOA/BID/NFKB1/SPHK1/DEGS1/TNFRSF1A/BAX/TRADD/ROCK1/SGPL1/CERS2/CERS6/RAC2/SGMS2/MAPK1/KRAS/GNAQ/PIK3R1/S1PR4/SMPD1/PLCB2/NSMAF/PPP2R3C/PPP2R5C/MAP3K5/GNA12/ORMDL2/ORMDL1/SGMS1/PLD1/BCL2/PLD2/PPP2R5A/RAC1/NRAS/SPTLC2/PIK3CA/MAP2K1/PRKCB/PIK3CD/PPP2R2D/MAPK8/ABCC1/SPHK2/PPP2R5B	5.05238300550428
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	26/2020	50/9376	2.41362376237624	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/CXCR4/TNFSF13B/HLA-DQA2/CD86/HLA-DOA/CD40/IL10/TGFB1/LTBR/ICOSLG/ITGB7/ITGA4/IL15/IL15RA/CD80/IL6/TNFSF13/HLA-DQB2	5.25184132401868
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	59/2020	156/9376	1.75547093170856	STAT1/CD81/NFKBIA/NR1H3/CDKN1A/JAK1/SOCS3/CFLAR/BID/NFKB1/OAS1/IFNAR1/TNFRSF1A/STAT2/YWHAH/STAT3/BAX/TRADD/OAS2/GRB2/MX2/PIAS1/TRAF3/MAPK1/KRAS/PIK3R1/IRF7/IFNAR2/MX1/SCARB1/SOS2/BAK1/CXCL10/IKBKG/CASP8/CYCS/YWHAG/SOS1/CLDN23/IKBKE/TICAM1/IKBKB/RXRA/CDK6/NRAS/PIK3CA/MAP2K1/FAS/IFIT1/RSAD2/RNASEL/RIPK1/PIK3CD/CHUK/ARAF/PPP2R2D/TRAF6/CASP9/CLDN1	4.98603198242861
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	23/2020	42/9376	2.54181989627534	HMOX1/SAT1/FTL/FTH1/PRNP/ACSL1/TFRC/ACSL3/CYBB/MAP1LC3B/ATG7/SAT2/SLC3A2/STEAP3/SLC11A2/GPX4/ACSL5/GCLC/SLC39A8/NCOA4/LPCAT3/ACSL6/PCBP1	5.24764992565565
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	52/2020	133/9376	1.81475470855356	FCGR3A/HLA-B/ITGB2/HLA-A/CD48/FCER1G/TYROBP/IFNGR2/HLA-E/HLA-C/HCST/PTPN6/IFNGR1/LCP2/ICAM1/BID/SYK/IFNAR1/SH3BP2/LAT2/GRB2/TNFSF10/ITGAL/RAC2/VAV1/MAPK1/KRAS/PIK3R1/IFNAR2/ICAM2/PAK1/SOS2/PTK2B/TNFRSF10B/LAT/SOS1/PLCG2/MICA/MICB/TNFRSF10A/RAC1/NRAS/PIK3CA/MAP2K1/FAS/PPP3CB/PRKCB/PIK3CD/ARAF/PPP3CC/NFATC1/FCGR3B	4.95891524439348
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	35/2020	78/9376	2.08276212236608	ITGB2/LY96/JUN/GNAI2/PYCARD/C1QB/IRF8/C3/C1QA/FOS/IRF1/RHOA/NFKB1/C2/CASP1/C1QC/ITGAM/TLR4/SERPING1/IRAK1/IL10/MYD88/MAPK1/IL1B/CFL1/IRAK4/TICAM1/CASP7/NLRP3/TRAF6/MAPK8/IL23A/IL6/IL1A/CXCL5	5.03183101585391
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	71/2020	201/9376	1.63956455347027	BCL2A1/SPI1/ID2/REL/GADD45B/CD86/FCGR1A/CEBPB/MITF/NR4A3/PBX3/CDKN1A/CEBPA/JMJD1C/NUPR1/BMP2K/BIRC3/NFKB1/MMP9/CD40/ITGAM/TGFBR2/ETV6/CSF1R/BAX/LYL1/MAX/DDX5/PTCRA/ATM/BCL6/NFKBIZ/BCL2L1/CDK14/KMT2A/NCOR1/LMO2/KLF3/GADD45G/FLI1/PLAU/BAK1/PML/BIRC2/ITGB7/POLK/RARA/RUNX2/CDK9/DDB2/TFE3/RXRA/HHEX/ELK4/TRAF1/DDIT3/HPGD/AFF1/CEBPE/LDB1/CCNT2/RXRB/FOXO1/ZBTB17/SLC45A3/KDM6A/DOT1L/CCNT1/PAX8/IL6/SMAD1	4.8030802263419
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	33/2020	73/9376	2.0982503729825	CXCR4/BST2/SAMHD1/CD4/ELL2/MDFIC/RANBP2/APOBEC3C/PDCD6IP/SERINC3/APOBEC3G/MX2/MX1/CHMP4A/AFF4/MAP1S/SUPT4H1/CHMP4B/CREBBP/BICD2/CCR5/CDK9/FURIN/EP300/APOBEC3A/ELL/HGS/CCNT2/SERINC5/BICD1/APOBEC3F/KAT2B/CCNT1	4.93618856536979
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	106/2020	333/9376	1.47750126363988	SPP1/HLA-F/HLA-B/HLA-A/ATP6V0D1/STAT1/HLA-E/ATP6AP1/ATP6V0B/HLA-C/ATP6V1F/FN1/ATP6V0E1/TCIRG1/PTGER4/ATP6V1B2/BCAP31/CDKN1A/NOTCH2/JAK1/IRF1/ATP6V1A/NFKB1/VEGFA/ITGAV/IFNAR1/TNFRSF1A/ATP6V1D/LFNG/STAT2/PRKACB/UBR4/BAX/TRADD/ATP6V1G1/ATP6V1C1/GRB2/ATP6V0A1/MX2/ATM/UBE3A/TRAF3/APC/MAPK1/MFNG/PSEN1/KRAS/MAML2/PIK3R1/ATP6V1H/IFNAR2/MX1/OASL/CREB3L2/ITGA6/TADA3/ITGB5/PPP2R3C/SOS2/PPP2R5C/BAK1/IKBKG/CASP8/CREBBP/CHD4/RFNG/ITGB7/THBS3/ITGA4/CREB5/PTGS2/SOS1/CREB3/PRKACA/IKBKE/TICAM1/RBL2/IKBKB/CDK6/PPP2R5A/EP300/CREB1/NRAS/PIK3CA/MAP2K1/FAS/LAMB3/NOTCH1/ATP6V0D2/PIK3CD/CHUK/HES1/FOXO1/PPP2R2D/HES4/COL9A2/FZD2/MAML3/ATP6V0A2/TSC2/JAG1/PPP2R5B/ITGB3/IBSP/ATP6V0C/ITGA3	4.64922794125885
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	61/2020	168/9376	1.68533710513909	STAT1/IFNGR2/CSH1/OSM/PTPN6/IFNGR1/CDKN1A/IL13RA1/IL10RA/IL10RB/JAK1/SOCS3/MCL1/IL2RG/STAT5A/IFNAR1/STAT2/CSF3R/CSH2/STAT3/IL6R/GRB2/IL10/IL7R/PIAS1/BCL2L1/PIK3R1/IFNAR2/STAT6/IL27RA/JAK2/SOS2/IL4R/CREBBP/PTPN2/SOS1/IL15/SOCS6/IL15RA/STAM2/CSF2RB/BCL2/EP300/IL12RB1/SOCS1/PIK3CA/PIK3CD/IFNLR1/SOCS4/IL7/IL3RA/SOCS5/LEPR/CLCF1/IL23A/JAK3/IL21R/IL6/PDGFB/STAT4/FHL1	4.69695818621461
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	54/2020	144/9376	1.74059405940594	C5AR1/LY96/ALDH2/CXCL2/NFKBIA/CXCL3/C3AR1/C1QB/C3/C1QA/NFKB1/C2/C1QC/PRKAG2/TNFRSF1A/TLR4/TRADD/IRAK1/CPT1A/FOXO3/ALDH3A2/ACADVL/LPIN2/MYD88/TRAF3/TAB2/ACADM/IL1B/MAP3K5/IKBKG/CASP8/IL17RA/IRAK4/ADIPOR1/MAP2K3/IKBKE/TICAM1/ACOX1/IKBKB/PRKAA1/SREBF1/FAS/ADIPOR2/IL17RC/RIPK1/CHUK/MLYCD/FOXO1/SIRT1/TRAF6/MAP2K7/MAPK8/IL6/ACACB	4.6930376121794
Human Diseases	Immune disease	hsa05330	Allograft rejection	21/2020	39/9376	2.4993145468393	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-F/HLA-B/HLA-A/HLA-DQA2/HLA-E/HLA-C/CD86/HLA-DOA/CD40/IL10/FAS/CD80/HLA-DQB2	4.9165656368534
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	35/2020	82/9376	1.98116397005554	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/CD74/CTSS/HLA-F/HLA-B/HLA-A/IFI30/LGMN/HLA-DQA2/TAPBP/CD4/CTSB/HSPA1B/HLA-E/HSPA1A/HLA-C/B2M/CTSL/TAP1/HLA-DOA/TAPBPL/CIITA/PSME2/HSPA6/CANX/RFX5/CREB1/HLA-DQB2	4.67614152313718
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	13/2020	19/9376	3.17582073996873	HEXB/HEXA/GNS/IDS/GUSB/GLB1/NAGLU/GALNS/ARSB/HPSE/HGSNAT/SGSH/IDUA	4.97475916190408
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	60/2020	168/9376	1.65770862800566	GLUL/CHMP1B/STAT1/IFNGR2/FTL/FTH1/PYCARD/SQSTM1/IFNGR1/TNFAIP3/JAK1/BIRC3/CFLAR/BID/CASP1/STAT5A/IFNAR1/TNFRSF1A/CYBB/STAT2/TLR4/STAT3/BAX/TRADD/CHMP3/CYLD/TNFSF10/XIAP/CAMK2D/IFNAR2/STAT6/SMPD1/IL1B/CHMP4A/JAK2/CAPN2/CASP8/CHMP4B/SHARPIN/BIRC2/TNFRSF10B/CHMP5/PYGB/PLA2G4C/TICAM1/BCL2/TNFRSF10A/RIPK3/TRPM7/FAS/NLRP3/MLKL/RIPK1/PLA2G4A/SPATA2L/MAPK8/JAK3/IL1A/ZBP1/STAT4	4.50760640462946
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	70/2020	205/9376	1.58493117604443	HLA-F/HLA-B/HLA-A/ATP6V0D1/GSN/REL/HLA-E/JUN/NFKBIA/HLA-C/C3/CDKN1A/JAK1/RHOA/LYN/NFKB1/SYK/SP100/STAT5A/PRKACB/YWHAH/UBR4/STAT3/BAX/TRADD/GRB2/UBE3A/NFKB2/TRAF3/MAPK1/KRAS/VAC14/PIK3R1/IRF7/LTBR/CREB3L2/BAK1/IKBKG/CASP8/CREBBP/MAPKAPK2/CHD4/YWHAG/CREB5/CREB3/CCR5/PRKACA/MAD1L1/RBL2/CDK6/SRC/TRAF1/ATF6B/RAC1/EP300/CREB1/HDAC10/NRAS/PIK3CA/USP7/HDAC7/ATP6V0D2/PIK3CD/POLB/RASA2/SCIN/KAT2B/JAK3/HDAC4/CDKN2B	4.4372491586958
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	18/2020	32/9376	2.61089108910891	BIRC3/BID/TNFRSF1A/BAX/XIAP/BCL2L1/BECN1/BIRC6/BAK1/CASP8/CYCS/BIRC2/BCL2L11/BCL2/CASP7/BBC3/MAPK8/CASP9	4.7831633867524
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	52/2020	142/9376	1.69973504392693	NCF2/DUSP1/HMOX1/JUN/CYBA/GSTO1/CTSL/SDC2/NFE2L2/SQSTM1/MGST1/MGST2/FOS/RHOA/ICAM1/MEF2A/NFKB1/MMP9/VEGFA/ITGAV/TNFRSF1A/KLF2/RAC2/ARHGEF2/NCF1/PIK3R1/SUMO3/IL1B/BMPR2/GSTT1/MAP3K5/IKBKG/ACTB/BCL2/IKBKB/PRKAA1/THBD/SRC/RAC1/PIK3CA/ACVR1/PIK3CD/CHUK/GSTM4/MAPK7/MAP2K7/MAPK8/ACVR2A/ITGB3/PDGFB/IL1A/EDN1	4.40274288983698
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	22/2020	44/9376	2.32079207920792	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-F/HLA-B/HLA-A/HLA-DQA2/HLA-E/HLA-C/CD86/HLA-DOA/IL1B/FAS/CD80/ICA1/IL1A/HLA-DQB2	4.60165326695289
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	42/2020	109/9376	1.7885003179217	CD36/NFKBIA/NR1H3/SOCS3/NFKB1/RPS6KA1/PRKAG2/SLC27A1/TNFRSF1A/STAT3/PCK2/CPT1A/MLXIP/NR1H2/PIK3R1/RPS6KA3/RPS6KA2/CREB3L2/MLX/PTPN1/PRKCD/IRS2/PPARGC1B/CREB5/CREB3/PYGB/SLC27A3/IKBKB/PRKAA1/G6PC3/CREB1/SREBF1/PIK3CA/PRKCB/SLC27A4/PIK3CD/FOXO1/CRTC2/MAPK8/PPP1R3D/IL6/ACACB	4.33896356070517
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	76/2020	232/9376	1.52051894844657	CXCR4/ITGB2/RGCC/ITGAX/GSN/MSN/FN1/TMSB4X/GNA13/IQGAP2/MRAS/RRAS/NCKAP1L/ARPC1B/RHOA/ARPC4/ACTR3/LIMK1/ARPC3/ITGAV/ITGAM/ACTR2/ROCK1/ITGAL/RAC2/VAV1/SPATA13/APC/PIP4K2A/MAPK1/KRAS/ARPC2/PIK3R1/CYFIP1/SSH1/IQGAP1/ITGA6/PAK1/ITGB5/SOS2/GNA12/ACTB/ITGB7/ITGA4/SOS1/TIAM1/CFL1/SSH2/ARHGEF6/ARHGEF1/WASF2/BAIAP2/ARHGAP35/PAK2/SRC/RAC1/NRAS/DIAPH1/PIK3CA/MAP2K1/PPP1R12C/DIAPH2/LPAR1/PDGFC/PIK3CD/ARAF/PIKFYVE/LPAR2/FGD3/SCIN/LPAR5/MYL5/ITGAD/ITGB3/PDGFB/ITGA3	4.20680992769524
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	22/2020	45/9376	2.26921892189219	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-F/HLA-B/HLA-A/HLA-DQA2/HLA-E/HLA-C/CD86/HLA-DOA/IL1B/FAS/CD80/IL6/IL1A/HLA-DQB2	4.47217884469138
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	37/2020	93/9376	1.84665176195039	GADD45B/NFKBIA/FN1/CDKN1A/BIRC3/NFKB1/ITGAV/BAX/MAX/XIAP/TRAF3/BCL2L1/PIK3R1/ITGA6/GADD45G/BAK1/IKBKG/CYCS/BIRC2/POLK/PTGS2/DDB2/BCL2/IKBKB/RXRA/CDK6/TRAF1/PIK3CA/LAMB3/PIK3CD/CHUK/RXRB/ZBTB17/TRAF6/CASP9/CDKN2B/ITGA3	4.29974379275123
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	12/2020	18/9376	3.09438943894389	HEXB/HEXA/FUCA1/MANBA/GLB1/FUCA2/MAN2B2/AGA/MAN2B1/MAN2C1/ENGASE/NEU3	4.66060861939363
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	25/2020	55/9376	2.10981098109811	ASAH1/HEXB/HEXA/PSAP/GLA/GM2A/UGCG/GLB1/SPHK1/DEGS1/ACER3/GALC/SGPL1/CERS2/CERS6/ARSA/SGMS2/SMPD1/B4GALT5/SGMS1/CERK/SAMD8/SPTLC2/SPHK2/NEU3	4.32553241639994
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	39/2020	101/9376	1.79229487305166	STAT1/JUN/FN1/VEGFB/ICAM1/NFKB1/VEGFA/SERPINE1/STAT5A/TGFBR1/TGFBR2/CYBB/STAT3/BAX/MAPK1/KRAS/PIK3R1/TGFB1/PLCB2/IL1B/JAK2/PRKCD/PLCG2/SMAD2/BCL2/THBD/RAC1/NRAS/DIAPH1/PIK3CA/PRKCB/PIK3CD/FOXO1/MAPK8/NFATC1/IL6/IL1A/EDN1/TGFB2	4.19499102488301
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	45/2020	122/9376	1.71205973056322	PTPRC/CD4/JUN/NFKBIA/PTPN6/NFKBIE/FOS/LCP2/RHOA/NFKB1/MAP3K8/NCK1/GRB2/IL10/VAV1/MAPK1/KRAS/PIK3R1/PAK1/PPP2R3C/SOS2/PPP2R5C/BCL10/IKBKG/LAT/SOS1/NFATC3/MALT1/IKBKB/PAK2/PPP2R5A/NRAS/PIK3CA/MAP2K1/PPP3CB/NFKBIB/PIK3CD/CHUK/PPP2R2D/TEC1/PPP3CC/MAP2K7/MAPK8/NFATC1/PPP2R5B	4.14831814377477
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	54/2020	157/9376	1.59646843665258	HLA-F/HLA-B/HLA-A/ZFP36L2/HLA-E/GADD45B/HLA-C/SQSTM1/MRAS/CDKN1A/RRAS/NFKB1/HIPK2/SERPINE1/TGFBR1/TGFBR2/FOXO3/ATM/RASSF5/MAPK1/ITPR1/KRAS/PIK3R1/TGFB1/NBN/GADD45G/CAPN2/HIPK3/MAPKAPK2/HIPK1/NFATC3/ZFP36L1/MAP2K3/HUS1/SMAD2/RBL2/CDK6/FBXW11/NRAS/TRPM7/PIK3CA/MAP2K1/PPP3CB/PIK3CD/MCU/FOXO1/SIRT1/PPP3CC/TSC2/NFATC1/IL6/IL1A/CDKN2B/TGFB2	3.94944298273487
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	29/2020	70/9376	1.92294200848656	JUN/CDKN1A/HIF1A/RAP1A/VEGFA/HGF/GRB2/RAP1B/RAPGEF1/MAPK1/KRAS/PIK3R1/TGFB1/PAK1/SOS2/CREBBP/SOS1/TFE3/PAK2/RAC1/EP300/NRAS/PIK3CA/MAP2K1/FLCN/PIK3CD/ARAF/PDGFB/TGFB2	4.06146179462341
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	23/2020	51/9376	2.09326344399146	ATP6V0D1/ATP6AP1/ATP6V0B/ATP6V1F/ATP6V0E1/TCIRG1/ATP6V1B2/ATP6V1A/ATP6V1D/PRKACB/ATP6V1G1/ATP6V1C1/ATP6V0A1/ATP6V1H/ADCY3/ACTB/PRKACA/PLCG2/KCNQ1/ATP6V0D2/ATP6V0A2/SLC12A2/ATP6V0C	4.1022862094656
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	31/2020	77/9376	1.86868972611547	GADD45B/NFKBIA/CDKN1A/NFKB1/STAT5A/TGFBR1/TGFBR2/BAX/GRB2/CBL/MAPK1/KRAS/BCL2L1/PIK3R1/TGFB1/GADD45G/SOS2/BAK1/IKBKG/POLK/SOS1/DDB2/IKBKB/CDK6/NRAS/PIK3CA/MAP2K1/PIK3CD/CHUK/ARAF/TGFB2	4.0108127473611
Organismal Systems	Immune system	hsa04611	Platelet activation	45/2020	126/9376	1.65770862800566	APBB1IP/FCER1G/FERMT3/GNAI2/VAMP8/GNA13/TLN1/TBXAS1/BTK/RAP1A/LCP2/RHOA/LYN/SYK/PRKACB/FCGR2A/PTGS1/PIK3R5/ROCK1/ADCY7/RAP1B/MAPK1/ITPR1/GNAQ/PIK3R1/ADCY3/PLCB2/VASP/ORAI1/ACTB/PRKACA/PLCG2/PLA2G4C/ARHGEF1/SNAP23/ARHGAP35/SRC/PIK3CA/PIK3CD/STIM1/PLA2G4A/PIK3CG/PIK3R6/TLN2/ITGB3	3.89482911586402
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	90/2020	298/9376	1.40182071898465	CXCL16/CXCR4/IL18/TNFSF13B/CD4/IFNGR2/TNFRSF14/CXCL2/TNFSF12/CSH1/CXCL3/OSM/CCL18/IFNGR1/IL13RA1/IL10RA/IL10RB/IL1RN/IL2RG/CD40/IFNAR1/TGFBR1/TGFBR2/TNFRSF1B/CCL20/TNFRSF1A/CSF3R/CSH2/CSF1R/IL6R/IL10/TNFSF10/IL7R/CCL3/CXCL9/RELT/TGFB1/IFNAR2/LTBR/IL27RA/IL1B/CCL7/BMPR2/CCR1/IL4R/TNFSF14/CXCL10/IL17RA/CCL23/TNFRSF10B/CSF1/IL15/CCR5/CCL5/IL15RA/CSF2RB/TNFRSF10A/IL16/IL12RB1/FAS/ACVR1/CXCL11/IL17RC/IL32/TNFRSF12A/TNFRSF21/ACVR1B/IFNLR1/TNFSF8/CXCR2/ACKR3/TNFRSF9/IL7/IL3RA/LEPR/CLCF1/TNFSF9/ACVR2A/CCL22/IL23A/IL21R/RELL2/IL6/TNFRSF8/TNFSF13/INHBA/IL1A/CXCL5/CCR2/TGFB2	3.69390593425888
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	28/2020	69/9376	1.88354139761802	FCER1G/ALOX5AP/ALOX5/BTK/LCP2/LYN/SYK/GRB2/RAC2/VAV1/MAPK1/KRAS/PIK3R1/SOS2/INPP5D/LAT/SOS1/PLCG2/PLA2G4C/MAP2K3/RAC1/NRAS/PIK3CA/MAP2K1/PIK3CD/PLA2G4A/MAP2K7/MAPK8	3.859997771047
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	30/2020	76/9376	1.83220427305889	OLR1/CYP27A1/CD36/LPL/FABP5/PLIN2/NR1H3/PLTP/ACSL1/FABP3/GK/SLC27A1/ACSL3/PCK2/CPT1A/FABP4/UBC/SCP2/DBI/ACADM/ACAA1/ME3/ACSL5/ME1/ACOX1/RXRA/ACSL6/ACOX2/SLC27A4/RXRB	3.81711923261917
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	32/2020	83/9376	1.78952642252177	IL18/DNASE2/SAMHD1/NFKBIA/PYCARD/IFI16/POLR3GL/NFKB1/CASP1/TREX1/IRF7/IL1B/ADAR/CXCL10/IKBKG/CASP8/CCL5/IKBKE/AIM2/IKBKB/RIPK3/CASP7/DNASE2B/NLRP3/MLKL/RIPK1/NFKBIB/PCBP1/CHUK/ZDHHC1/IL6/ZBP1	3.78589189857105
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	30/2020	78/9376	1.78522467631379	PI4K2A/PIP4K2A/MTMR14/PLCB2/ITPK1/MTMR6/FIG4/INPP5D/PLCG2/MTMR3/ITPKB/INPP1/PPIP5K2/INPPL1/SACM1L/IMPA1/PIK3CA/INPP4A/PI4KB/MINPP1/PIK3CD/PIK3C3/MTM1/PIKFYVE/PIK3CG/PI4KA/INPP5K/IPMK/OCRL/PPIP5K1	3.64910980821481
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	36/2020	99/9376	1.68784878487849	JUN/GPCPD1/HIF1A/FOS/WAS/GRB2/RAC2/MAPK1/KRAS/PIK3R1/PCYT1A/RALGDS/SOS2/SLC44A1/SOS1/PLA2G4C/PLD1/WASF2/PLD2/DGKH/RAC1/NRAS/PIK3CA/MAP2K1/PRKCB/SLC22A4/PDGFC/PIK3CD/PLA2G4A/CHKB/DGKQ/MAPK8/TSC2/DGKG/PDGFB/SLC22A5	3.6053485433155
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	29/2020	75/9376	1.79474587458746	GSTO1/MGST1/CDKN1A/SLC31A1/MGST2/BIRC3/BID/ERCC1/BAX/XIAP/ATM/MAPK1/BCL2L1/PIK3R1/GSTT1/BAK1/MAP3K5/CASP8/CYCS/BIRC2/ATP7A/REV3L/BCL2/PIK3CA/FAS/BBC3/PIK3CD/GSTM4/CASP9	3.62105027280318
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	29/2020	75/9376	1.79474587458746	GADD45B/CD82/CDKN1A/BID/ZNF385A/SERPINE1/TP53I3/BAX/ATM/STEAP3/BCL2L1/ZMAT3/RRM2B/GADD45G/CASP8/CYCS/TNFRSF10B/AIFM2/DDB2/SESN3/BCL2/TNFRSF10A/CDK6/FAS/BBC3/PPM1D/GORAB/CASP9/TSC2	3.62105027280318
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	16/2020	33/9376	2.25046504650465	STX4/STX11/VAMP8/VAMP5/STX6/STX7/VAMP3/STX8/VAMP4/STX16/STX5/SNAP23/VAMP7/STX3/VTI1A/BET1L	3.77073328714774
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	36/2020	100/9376	1.6709702970297	CXCR4/IL18/TNFRSF14/CXCL2/CXCL3/CCL18/IL10RA/IL10RB/IL2RG/TNFRSF1B/CCL20/TNFRSF1A/CSF1R/IL6R/IL10/TNFSF10/CCL3/CXCL9/LTBR/CCL7/CCR1/TNFSF14/CXCL10/CCL23/TNFRSF10B/CSF1/CCR5/CCL5/TNFRSF10A/CXCL11/CXCR2/ACKR3/CCL22/IL6/CXCL5/CCR2	3.53478812728929
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	34/2020	94/9376	1.67887086580999	CXCL2/JUN/NFKBIA/S100A8/CXCL3/CEBPB/TNFAIP3/FOS/NFKB1/MMP9/JUND/CCL20/FOSB/TRADD/TRAF3/MAPK1/TAB2/IL1B/CCL7/CXCL10/IKBKG/CASP8/IL17RA/PTGS2/IKBKE/IKBKB/IL17RC/CHUK/MAPK7/TRAF6/MAPK8/IL6/CXCL5/FOSL1	3.46633696455314
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	14/2020	28/9376	2.32079207920792	ATP6V0D1/ATP6V1F/ATP6V0E1/TCIRG1/ATP6V1B2/ATP6V1A/ATP6V1D/ATP6V1G1/ATP6V1C1/ATP6V0A1/ATP6V0D2/SLC12A7/ATP6V0A2/ATP6V0C	3.66770656168446
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	49/2020	149/9376	1.52642700511662	FCER1G/GNA13/MRAS/RRAS/AGPAT2/RHOA/SYK/SPHK1/CYTH1/RALA/PIK3R5/GRB2/ADCY7/AGPAT3/MAPK1/KRAS/PIK3R1/ADCY3/PLCB2/RALGDS/SOS2/GNA12/PTK2B/CYTH4/SOS1/PLCG2/PLA2G4C/PLD1/AGPAT4/PLD2/DGKH/NRAS/PIK3CA/MAP2K1/LPAR1/PDGFC/PIK3CD/PLA2G4A/PIK3CG/PIK3R6/LPAR2/CXCR2/DGKQ/LPAR5/TSC2/SPHK2/CYTH3/DGKG/PDGFB	3.39423178876545
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	21/2020	50/9376	1.94946534653465	IL18/ITGB2/LRP1/CD36/CD81/SDC2/ICAM1/CD40/TLR4/HGF/TLR2/IL10/ITGAL/MYD88/TGFB1/IL1B/THBS3/CR1/IL6/TGFB2/CR1L	3.52741760245486
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	24/2020	60/9376	1.85663366336634	HSPB1/VEGFA/SPHK1/MAPKAPK3/RAC2/MAPK1/KRAS/PIK3R1/MAPKAPK2/PTGS2/PLCG2/PLA2G4C/SRC/RAC1/NRAS/PIK3CA/MAP2K1/PPP3CB/PRKCB/PIK3CD/PLA2G4A/PPP3CC/CASP9/SPHK2	3.48816070130531
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	63/2020	204/9376	1.43343040186372	CD44/PLAUR/MSN/FN1/CD63/FLNA/CTSL/SDC2/MRAS/PTPN6/CDKN1A/HIF1A/HBEGF/RRAS/RHOA/MMP9/VEGFA/ITGAV/HCLS1/PRKACB/TLR4/TIMP3/STAT3/ROCK1/HGF/TLR2/GRB2/DDX5/CBL/VAV1/CAMK2D/MAPK1/ITPR1/KRAS/PIK3R1/TGFB1/HPSE/IQGAP1/PAK1/ITGB5/PLAU/SOS2/ACTB/SOS1/TIAM1/PRKACA/PLCG2/ARHGEF1/SMAD2/SRC/RAC1/NRAS/PIK3CA/MAP2K1/FAS/PPP1R12C/PRKCB/PIK3CD/ARAF/FZD2/ELK1/ITGB3/TGFB2	3.27976626013586
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	35/2020	99/9376	1.64096409640964	HLA-DPA1/HLA-DPB1/HLA-DMA/FCGR3A/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/C5AR1/ITGB2/FPR3/HLA-DQA2/FCGR1A/CFD/C3AR1/C1QB/C3/HLA-DOA/C1QA/ICAM1/PTAFR/C2/C1QC/ITGAM/FCGR2A/IL10/FPR1/ITGAL/SELPLG/FCGR2B/CAMP/FCGR3B/HLA-DQB2/FPR2	3.35960318911702
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	26/2020	68/9376	1.77472335468841	BCL2A1/SPI1/FCGR1A/CEBPA/NFKB1/STAT5A/ITGAM/CSF1R/STAT3/GRB2/MAPK1/KRAS/PIK3R1/SOS2/IKBKG/PML/RARA/SOS1/IKBKB/NRAS/PIK3CA/MAP2K1/CEBPE/PIK3CD/CHUK/ARAF	3.35979964618168
Human Diseases	Immune disease	hsa05310	Asthma	15/2020	32/9376	2.17574257425743	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/FCER1G/HLA-DQA2/PRG2/HLA-DOA/CD40/IL10/HLA-DQB2	3.49109190028794
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	41/2020	122/9376	1.55987664340205	STAT1/ATP1B3/HIF1A/NOTCH2/ITGAV/SLC16A10/PRKACB/ATP1B1/MAPK1/KRAS/PIK3R1/PLCB2/MED13/NCOR1/ATP2A2/THRA/MED13L/CREBBP/ACTB/ATP1A1/PRKACA/PLCG2/RXRA/SRC/EP300/NRAS/PIK3CA/MAP2K1/NCOA1/NOTCH1/PRKCB/PFKFB2/PIK3CD/MED14/RXRB/FOXO1/CASP9/TSC2/KAT2B/ITGB3/ATP2A3	3.26172979373984
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	9/2020	15/9376	2.7849504950495	HEXB/HEXA/GLB1/ST3GAL5/ST6GALNAC4/B3GALT4/ST3GAL1/ST6GALNAC6/ST3GAL2	3.62536005394799
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	36/2020	104/9376	1.60670220868241	PLD3/GPCPD1/AGPAT2/PLA2G15/LPCAT2/LPGAT1/LPIN2/AGPAT3/SGMS2/PNPLA6/PCYT1A/CDS2/ETNK1/GPD2/CEPT1/SGMS1/PTDSS1/PLA2G4C/PLD1/AGPAT4/PLD2/LPCAT3/DGKH/SAMD8/MBOAT1/PLD4/GNPAT/PLA2G4A/MBOAT7/CHKB/DGKQ/LPCAT4/DGKG/GDPD5/ADPRM/PLA1A	3.26021316494374
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	51/2020	160/9376	1.47950495049505	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-F/HLA-B/ITGB2/ALCAM/HLA-A/PTPRC/HLA-DQA2/CD4/HLA-E/HLA-C/CD86/SDC2/CD58/CADM1/HLA-DOA/ICAM1/CD40/ITGAV/ITGAM/SPN/CD99/GLG1/SDC3/ITGAL/SELPLG/ICAM2/ITGA6/CD22/SIGLEC1/ICOSLG/ITGB7/ITGA4/CLDN23/PDCD1LG2/CD80/CD99L2/CD6/PTPRM/MAG/HLA-DQB2/CD274/CLDN1/SELL	3.20569585893235
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	43/2020	130/9376	1.53529322162986	JUN/GNAI2/NFKBIA/ARRB2/GNB4/VEGFB/FOS/NFKB1/MMP9/VEGFA/TGFBR1/TGFBR2/PRKACB/GNA15/GRB2/ADCY7/MAPK1/KRAS/PIK3R1/TGFB1/ADCY3/PLCB2/CREB3L2/GNGT2/SOS2/ARRB1/CREB5/SOS1/CREB3/PRKACA/GNB1/SMAD2/SRC/ATF6B/CREB1/NRAS/PIK3CA/MAP2K1/GNG7/PIK3CD/MAP2K7/MAPK8/EDN1	3.22052695341322
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	29/2020	80/9376	1.68257425742574	JAK1/VEGFA/STAT3/BAX/IL6R/HGF/GRB2/FOXO3/AXL/MAPK1/KRAS/BCL2L1/PIK3R1/JAK2/SOS2/SOS1/PLCG2/BCL2L11/BCL2/SRC/NRAS/PIK3CA/MAP2K1/PRKCB/PDGFC/PIK3CD/ARAF/IL6/PDGFB	3.21282672648887
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	101/2020	362/9376	1.29502762430939	SPP1/SGK1/FN1/CSH1/GNB4/OSM/VEGFB/CDKN1A/JAK1/SGK3/EREG/MCL1/NFKB1/SYK/VEGFA/IL2RG/ITGAV/IFNAR1/CSF3R/TLR4/PIK3AP1/CSH2/CSF1R/YWHAH/IL6R/PIK3R5/HGF/PCK2/TLR2/GRB2/AREG/FOXO3/IL7R/DDIT4/MAPK1/KRAS/BCL2L1/PIK3R1/NR4A1/IFNAR2/CREB3L2/GNGT2/JAK2/ITGA6/PKN1/ITGB5/PPP2R3C/SOS2/PPP2R5C/IL4R/IKBKG/YWHAG/ITGB7/THBS3/ITGA4/CREB5/CSF1/SOS1/CREB3/GNB1/BCL2L11/RBL2/BCL2/IKBKB/RXRA/PRKAA1/G6PC3/CDK6/ATF6B/PPP2R5A/RAC1/CREB1/NRAS/PKN2/PIK3CA/MAP2K1/LAMB3/GNG7/LPAR1/PDGFC/PIK3CD/CHUK/PPP2R2D/PIK3CG/CRTC2/COL9A2/PIK3R6/LPAR2/CASP9/IL7/IL3RA/LPAR5/TSC2/JAK3/PPP2R5B/ITGB3/IL6/PDGFB/IBSP/FLT3LG/ITGA3	2.99984387828636
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	40/2020	122/9376	1.52183087161175	STAT1/JUNB/GNAI2/CSH1/FOS/SOCS3/STAT5A/PRKACB/CSH2/STAT3/GRB2/ADCY7/MAPK1/ITPR1/KRAS/GNAQ/PIK3R1/ADCY3/PLCB2/CREB3L2/JAK2/SOS2/IRS2/CREBBP/CREB5/SOS1/CREB3/PRKACA/PLCG2/MAP2K3/ATF6B/EP300/CREB1/SOCS1/NRAS/PIK3CA/MAP2K1/PRKCB/PIK3CD/MAPK8	3.04008270623111
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	21/2020	54/9376	1.80506050605061	HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-F/HLA-B/HLA-A/HLA-DQA2/HLA-E/HLA-C/CD86/HLA-DOA/CD40/IL10/FAS/CD80/HLA-DQB2	3.10893265948347
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	32/2020	93/9376	1.59710422655169	MAP3K2/JUN/HBEGF/PRKACB/GRB2/ADCY7/CAMK2D/MAPK1/ITPR1/KRAS/GNAQ/ADCY3/PLCB2/PRKCD/SOS2/PTK2B/MAP3K3/SOS1/PRKACA/PLA2G4C/MAP2K3/PLD1/PLD2/SRC/NRAS/MAP2K1/PRKCB/MAPK7/PLA2G4A/MAP2K7/MAPK8/ELK1	3.03240990820921
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	26/2020	72/9376	1.67612761276128	NFKBIA/NFKB1/IFIH1/TRADD/CYLD/ZNFX1/TANK/TRAF3/AZI2/IRF7/ADAR/CXCL10/IKBKG/CASP8/DHX58/IKBKE/IKBKB/CASP10/RNF125/OTUD5/RIPK1/NFKBIB/CHUK/TRAF6/MAPK8/NLRX1	3.01787003364511
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	38/2020	116/9376	1.52051894844657	CXCR4/NCF2/ITGB2/MSN/GNAI2/CYBA/RAP1A/RHOA/ICAM1/MMP9/ITGAM/CD99/CYBB/ROCK1/ITGAL/NCF4/RAC2/RAP1B/RASSF5/NCF1/VAV1/PIK3R1/SIPA1/VASP/ACTB/PTK2B/ITGA4/PLCG2/CLDN23/ARHGAP35/RAC1/PIK3CA/PRKCB/CD99L2/PIK3CD/RHOH/MYL5/CLDN1	2.95597330486403
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	29/2020	83/9376	1.62175832041035	SOD2/CAT/ACSL1/GSTK1/ACSL3/HSD17B4/DHRS4/SCP2/HMGCL/ABCD1/ACAA1/AGPS/ACSL5/ACOX1/NUDT19/GNPAT/ACSL6/ACOX2/ABCD4/MLYCD/PEX14/DDO/PAOX/PEX26/PRDX1/PEX11G/PIPOX/PEX6/MPV17L	2.98141990054272
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	33/2020	98/9376	1.56298242069105	PI4K2A/PIP4K2A/MTMR14/ITPR1/PIK3R1/PLCB2/CDS2/ITPK1/MTMR6/INPP5D/PLCG2/MTMR3/ITPKB/INPP1/PPIP5K2/DGKH/INPPL1/SACM1L/IMPA1/PIK3CA/INPP4A/PRKCB/PI4KB/PIK3CD/PIK3C3/MTM1/PIKFYVE/PI4KA/DGKQ/IPMK/DGKG/OCRL/PPIP5K1	2.93576406665473
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	69/2020	238/9376	1.34566935685165	REL/GNB4/MRAS/VEGFB/RRAS/RAP1A/RHOA/RASGRP3/NFKB1/VEGFA/RALA/PRKACB/STK4/CSF1R/HGF/RAB5C/GRB2/RAC2/RAP1B/RASSF5/MAPK1/KRAS/ABL2/BCL2L1/PIK3R1/RALGDS/RASAL2/GNGT2/SHOC2/PAK1/SOS2/IKBKG/RASA3/RAB5A/LAT/RALGAPA1/CSF1/SOS1/RASA4/TIAM1/PRKACA/PLCG2/PLA2G4C/GNB1/PLD1/IKBKB/PLD2/PAK2/RAC1/NRAS/PIK3CA/MAP2K1/GNG7/PRKCB/RASAL3/PDGFC/PIK3CD/CHUK/PLA2G4A/RASSF1/RALGAPB/RASA2/MAPK8/EXOC2/RALGAPA2/ELK1/PDGFB/FLT3LG/PLA1A	2.8305070824355
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	20/2020	52/9376	1.78522467631379	APOE/APOC1/LIPA/CYP27A1/LRP1/NCEH1/CD36/LPL/TSPO/NPC2/ABCA1/SOAT1/PLTP/LRPAP1/APOC2/STARD3/NPC1/SCARB1/SORT1/OSBPL5	2.97532862976026
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	22/2020	59/9376	1.73076019466353	GADD45B/CDKN1A/BAX/GRB2/FOXO3/APC/MAPK1/KRAS/PIK3R1/GADD45G/SOS2/BAK1/POLK/SOS1/DDB2/NRAS/PIK3CA/MAP2K1/PIK3CD/ARAF/CASP9/ELK1	2.950552207608
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	43/2020	138/9376	1.44629071602812	FBP1/RHOQ/SOCS3/PRKAG2/HK3/PRKACB/PCK2/PRKAR1A/GRB2/CBL/RAPGEF1/MAPK1/KRAS/PIK3R1/PTPN1/SOS2/IRS2/PRKAR2A/SOS1/PRKACA/PYGB/FLOT1/HK2/IKBKB/PRKAA1/G6PC3/INPPL1/SOCS1/NRAS/SREBF1/PIK3CA/MAP2K1/PRKAR1B/PIK3CD/PDE3B/ARAF/FOXO1/SOCS4/MAPK8/TSC2/PPP1R3D/ELK1/ACACB	2.76763541594275
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	25/2020	71/9376	1.63436061916051	STAT1/FOS/IRF1/SOCS3/NFKB1/STAT5A/STAT3/GRB2/FOXO3/MAPK1/KRAS/PIK3R1/JAK2/SOS2/SOS1/SOCS6/SRC/SOCS1/NRAS/PIK3CA/MAP2K1/PIK3CD/SOCS4/MAPK8/SOCS5	2.81156198490896
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	17/2020	43/9376	1.83504489983882	ALDH2/ACAA2/ACSL1/ACSL3/CPT1A/HADHB/ALDH3A2/ACADVL/HADHA/ACADM/ACAA1/ACAT1/ACSL5/ACADS/ACOX1/ACSL6/CYP2U1	2.8759006924137
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	29/2020	86/9376	1.56518535574488	JUN/CDKN1A/HBEGF/EREG/STAT5A/NCK1/GRB2/AREG/CBL/CAMK2D/MAPK1/KRAS/ABL2/PIK3R1/PAK1/SOS2/SOS1/PLCG2/PAK2/SRC/NRAS/PIK3CA/MAP2K1/PRKCB/PIK3CD/ARAF/MAP2K7/MAPK8/ELK1	2.75913361159293
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	13/2020	30/9376	2.01135313531353	ABCC3/NFKB1/MTHFR/IL1B/IKBKG/FPGS/IKBKB/ABCC5/FOLR3/SLC46A1/CHUK/ABCC1/IL6	2.90730788945911
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	30/2020	90/9376	1.54719471947195	SOD2/CAT/NFKB1/PRKAG2/PRKACB/BAX/ADCY7/FOXO3/KRAS/PIK3R1/RB1CC1/ADCY3/CREB3L2/APPL1/IRS2/CREB5/CREB3/PRKACA/ADIPOR1/SESN3/PRKAA1/ATF6B/CREB1/NRAS/PIK3CA/ADIPOR2/PIK3CD/FOXO1/SIRT1/TSC2	2.73331242401397
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	59/2020	203/9376	1.34903184899771	SPP1/ZYX/JUN/FN1/FLNA/VEGFB/PARVG/TLN1/RAP1A/RHOA/BIRC3/VEGFA/ITGAV/EMP1/PARVB/ROCK1/HGF/GRB2/XIAP/RAC2/RAP1B/RAPGEF1/VAV1/MAPK1/PIK3R1/VASP/ITGA6/PAK1/ITGB5/SOS2/CAPN2/ACTB/BIRC2/ITGB7/THBS3/ITGA4/SOS1/BCL2/ARHGAP35/PAK2/SRC/RAC1/DIAPH1/PIK3CA/MAP2K1/LAMB3/PPP1R12C/PRKCB/PDGFC/PIK3CD/COL9A2/MAPK8/MYL5/TLN2/ELK1/ITGB3/PDGFB/IBSP/ITGA3	2.63449781542956
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	28/2020	83/9376	1.56583561970655	UBE2D1/PCGF5/MAX/DCAF7/UBE2D3/PHC2/ASXL2/CREBBP/KDM2A/UBE2D4/KDM2B/L3MBTL4/EP300/FOXK1/PHC3/USP7/CBX6/LCOR/FBRS/YAF2/JARID2/MBD6/SCML1/EZH1/MGA/BCOR/CBX7/CBX8	2.71326256786661
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	15/2020	37/9376	1.88172330746588	GADD45B/CDKN1A/BAX/MAPK1/KRAS/GADD45G/BAK1/POLK/DDB2/NCOA4/RXRA/NRAS/MAP2K1/RXRB/PAX8	2.81594039626637
Human Diseases	Cancer: specific types	hsa05214	Glioma	26/2020	76/9376	1.58791036998437	GADD45B/CDKN1A/CAMK1D/CAMK1/BAX/GRB2/CAMK2D/MAPK1/KRAS/PIK3R1/GADD45G/SOS2/BAK1/POLK/SOS1/PLCG2/DDB2/CDK6/NRAS/PIK3CA/MAP2K1/PRKCB/PIK3CD/ARAF/CAMK1G/PDGFB	2.69660232826609
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	14/2020	34/9376	1.91124053581829	PRKAG2/BHLHE40/BHLHE41/DBP/NR1D2/NFIL3/PER1/CSNK1D/PRKAA1/CREB1/FBXW11/CLOCK/PER3/CRY2	2.78928582924598
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	47/2020	157/9376	1.38951882449391	JUN/NR1H3/CEBPA/FOS/SOCS3/BID/NFKB1/PRKAG2/TNFRSF1A/BAX/IL6R/SDHB/ERN1/MLXIP/SDHD/PIK3R1/TGFB1/IL1B/MLX/NDUFB9/MAP3K11/NDUFB5/IRS2/MAP3K5/CASP8/CYCS/ADIPOR1/BCL2L11/IKBKB/RXRA/PRKAA1/RAC1/MT-CO1/DDIT3/SREBF1/PIK3CA/CASP7/FAS/ITCH/EIF2AK3/ADIPOR2/UQCRB/PIK3CD/MAPK8/LEPR/IL6/IL1A	2.57915137416847
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	46/2020	154/9376	1.38644721615019	RGS2/JUN/GNAI2/CDKN1A/FOS/RHOA/PRKAG2/CAMK1D/PRKACB/CAMK1/PIK3R5/ROCK1/ADCY7/CAMK2D/MAPK1/ITPR1/KRAS/GNAQ/ADCY3/PLCB2/CD38/KCNJ2/ACTB/PTGS2/KCNJ5/NFATC3/PRKACA/CACNA2D4/PLA2G4C/TRPM2/PRKAA1/SRC/NRAS/MAP2K1/PPP1R12C/PPP3CB/PRKCB/MAPK7/PLA2G4A/MYL6/PIK3CG/CAMK1G/PIK3R6/PPP3CC/NFATC1/ELK1	2.53383567942173
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	47/2020	158/9376	1.38072440155408	SGK1/ATP6V1F/RRAGD/ATP6V1B2/RHOA/ATP6V1A/RPS6KA1/FNIP2/TNFRSF1A/ATP6V1D/MAPKAP1/LAMTOR4/ATP6V1G1/ATP6V1C1/GRB2/CAB39/LPIN2/DDIT4/SLC3A2/MAPK1/KRAS/PIK3R1/ATP6V1H/RPS6KA3/FNIP1/RPS6KA2/LAMTOR2/RRAGC/SOS2/CLIP1/SOS1/LAMTOR3/IKBKB/PRKAA1/LAMTOR1/NRAS/PIK3CA/MAP2K1/FLCN/PRKCB/PIK3CD/CHUK/RICTOR/FZD2/PRR5L/TSC2/ULK2	2.52907301033983
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/2020	32/9376	1.88564356435644	GABARAP/GABARAPL1/ATG7/GABARAPL2/ATG3/BECN1/ATG4C/ATG4B/ATG2A/PIK3C3/ATG4A/PIK3R4/ULK2	2.62971090931163
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	20/2020	57/9376	1.62862602049679	PPT1/ACAA2/ACSL1/ACSL3/HSD17B4/CPT1A/HADHB/ACADVL/SCP2/HADHA/ACADM/ACAA1/ACAT1/ELOVL1/ACSL5/ACADS/HSD17B12/ACOX1/ACSL6/ACSF3	2.49451194705782
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	34/2020	110/9376	1.43467146714671	EMP3/HAMP/ID2/SKIL/RHOA/TFRC/TGIF1/ZFYVE16/TGFBR1/TGFBR2/SMAD7/ROCK1/SMURF2/MAPK1/TGFB1/NCOR1/BMPR2/CREBBP/SMAD2/EP300/TMEM53/SKI/ACVR1/ACVR1B/LEMD3/FBN1/SMAD6/HFE/ACVR2A/INHBA/SMAD1/CDKN2B/TGFB2/NOG	2.40298904170329
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	41/2020	139/9376	1.36910036327374	CTSD/HSPA1B/HSPA1A/JUN/GNAI2/HBEGF/FOS/MMP9/PRKACB/GRB2/ADCY7/FKBP5/MAPK1/HSPA6/ITPR1/KRAS/GNAQ/PIK3R1/ADCY3/PLCB2/CREB3L2/PRKCD/SOS2/RARA/CREB5/KCNJ5/SOS1/POMC/CREB3/PRKACA/BCL2/EBAG9/SRC/ATF6B/CREB1/NRAS/PIK3CA/MAP2K1/NCOA1/PIK3CD/GABBR1	2.29734840686352
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	16/2020	44/9376	1.68784878487849	STX4/ARHGDIB/PRKACB/RAB5C/ADCY3/DYNC1H1/CREB3L2/RAB5A/DYNC1LI1/CREB5/CREB3/PRKACA/ARHGDIA/NSF/CREB1/DCTN4	2.39647228199905
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	41/2020	140/9376	1.35932107496464	SPP1/SLC8A1/GNAI2/GNA13/GNB4/MRAS/RRAS/MEF2A/SPHK1/SERPINE1/PRKAG2/TGFBR1/MAP1LC3B/PRKACB/PIK3R5/KLF2/ADCY7/MAPK1/ITPR1/KRAS/GNAQ/ADCY3/PLCB2/GNGT2/BECN1/MEF2D/PRKACA/GNB1/SMAD2/PRKAA1/NRAS/MAP2K1/GNG7/PIK3C3/PDE3B/PIK3CG/PIK3R6/SPHK2/JAG1/PIK3R4/HDAC4	2.24463230285568
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	60/2020	217/9376	1.28338732490761	KLF4/JUN/GNAI2/GSTO1/ARRB2/MGST1/AHR/NOTCH2/MGST2/FOS/NFKB1/VEGFA/RPS6KA1/STAT5A/PRKACB/STAT3/GRB2/XIAP/ADCY7/BCL6/CYP1B1/KPNA3/VDR/MAPK1/KRAS/KPNA4/PIK3R1/RPS6KA3/EPHX1/ADCY3/RPS6KA2/CREB3L2/MIR29A/JAK2/GSTT1/SOS2/ARRB1/CREB5/SOS1/CREB3/PRKACA/IKBKE/BCL2/RXRA/SRC/ATF6B/CREB1/NRAS/PAQR8/PIK3CA/MAP2K1/PRKCB/PIK3CD/GSTM4/RXRB/KPNA1/PAQR5/JAG1/KPNA5/CACNA1A	2.21323088311825
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	22/2020	67/9376	1.52410226097237	RAP1A/RPS6KA1/PRKACB/RAP1B/CAMK2D/MAPK1/ITPR1/KRAS/GNAQ/RPS6KA3/PLCB2/RPS6KA2/CREBBP/PRKACA/EP300/NRAS/MAP2K1/PPP3CB/PRKCB/ARAF/PPP3CC/PPP1R1A	2.25601707365851
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	62/2020	227/9376	1.26774545295939	NCF2/SOD2/HMOX1/JUN/NFKBIA/CYBA/GSTO1/AKR1A1/NFE2L2/MGST1/AHR/HIF1A/CAT/MGST2/FOS/NFKB1/VEGFA/HGF/SDHB/GRB2/FOXO3/NCF1/CYP1B1/MAPK1/CBR1/SDHD/KRAS/ABL2/PPIF/PIK3R1/EPHX1/MT-ND4L/MT-ND2/NDUFB9/PTPN1/PRKCD/GSTT1/NDUFB5/SOS2/MAP3K5/IKBKG/SOS1/PLD1/PTPRJ/IKBKB/PLD2/SRC/RAC1/MT-CO1/NRAS/PIK3CA/MAP2K1/UQCRB/PIK3CD/CHUK/GSTM4/ARAF/AKR1C3/MAP2K7/MAPK8/MT-ND3/MT-ATP8	2.13987636274396
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	12/2020	31/9376	1.79674225487065	ALDH2/DPYD/ALDH3B1/ALDH3A2/HADHA/CNDP2/ACADS/ACOX1/MLYCD/ABAT/DPYS/CSAD	2.32835666189954
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	32/2020	106/9376	1.40123295348403	NFKBIA/CDKN1A/NFKB1/MMP9/GRB2/MAPK1/KRAS/PIK3R1/CREB3L2/PLAU/SOS2/IKBKG/CREBBP/CREB5/SOS1/CREB3/BCL2/IKBKB/FOLR3/EP300/CREB1/NRAS/PIK3CA/MAP2K1/SLC46A1/PDGFC/PIK3CD/CHUK/ARAF/FOXO1/CASP9/PDGFB	2.17695836376936
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/2020	21/9376	1.98925035360679	DSE/CHST11/CSGALNACT2/CHST13/B3GAT3/B3GALT6/CHPF2/CHST15/CHST7	2.37812363002734
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	36/2020	122/9376	1.36964778445058	FBP1/CD36/PRKAG2/PFKFB3/PCK2/CPT1A/CAB39/FOXO3/TBC1D1/PIK3R1/CREB3L2/PPP2R3C/PPP2R5C/IRS2/RAB10/CREB5/CREB3/ADIPOR1/PRKAA1/G6PC3/PPP2R5A/CREB1/SREBF1/PIK3CA/ADIPOR2/PFKFB2/PIK3CD/MLYCD/FOXO1/PPP2R2D/SIRT1/CRTC2/TSC2/LEPR/PPP2R5B/ACACB	2.15349435619618
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	58/2020	212/9376	1.2698673640949	ITGB2/APBB1IP/GNAI2/MRAS/VEGFB/TLN1/RRAS/RAP1A/LCP2/RHOA/DOCK4/RASGRP3/VEGFA/ITGAM/RALA/CSF1R/EVL/HGF/ADCY7/FPR1/ITGAL/RAC2/RAP1B/RAPGEF1/RASSF5/VAV1/MAPK1/KRAS/GNAQ/PIK3R1/SIPA1/ADCY3/PLCB2/RALGDS/RAPGEF2/VASP/ACTB/LAT/CSF1/TIAM1/MAP2K3/SRC/RAC1/SIPA1L2/NRAS/PIK3CA/MAP2K1/LPAR1/PRKCB/PDGFC/PIK3CD/LPAR2/ADORA2B/LPAR5/TLN2/ARAP3/ITGB3/PDGFB	2.08264966105097
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	34/2020	115/9376	1.37229444683599	GNAI2/GNB4/FOS/PRKACB/PIK3R5/ADCY7/CAMK2D/MAPK1/ITPR1/KRAS/GNAQ/PIK3R1/ADCY3/PLCB2/CREB3L2/GNGT2/JAK2/KCNJ2/CREB5/CREB3/PRKACA/GNB1/BCL2/CREB1/NRAS/PIK3CA/MAP2K1/KCNQ1/GNG7/PRKCB/PIK3CD/PIK3CG/PIK3R6/CACNA1A	2.10497527517498
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	21/2020	65/9376	1.49958872810358	ALDH2/LPL/MGLL/AKR1A1/GLA/AGPAT2/GK/ALDH3A2/LPIN2/AGPAT3/PNPLA2/DGAT1/AGPAT4/DGKH/MBOAT1/DGKQ/DGAT2/DGKG/ABHD16A/GLYCTK/PNPLA3	2.11793003249962
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	20/2020	62/9376	1.49728521239221	HSPA1B/HSPA1A/SOD2/CAT/PRKAG2/PRKACB/ADCY7/FOXO3/HSPA6/KRAS/PIK3R1/ADCY3/IRS2/PRKACA/PRKAA1/NRAS/PIK3CA/PIK3CD/FOXO1/SIRT1	2.05860837626175
NA	NA	hsa04518	Integrin signaling	43/2020	154/9376	1.2960267455317	SPP1/ITGB2/ITGAX/FERMT3/LIMS1/FN1/FLNA/C3/VEGFB/PARVG/TLN1/ICAM1/VEGFA/ITGAV/ITGAM/PARVB/HGF/ITGAL/RAC2/PIK3R1/TGFB1/ICAM2/ITGA6/ITGB5/ACTB/ITGB7/THBS3/ITGA4/ARHGEF6/SRC/RAC1/PIK3CA/LAMB3/PDGFC/PIK3CD/FBN1/COL9A2/ITGAD/TLN2/ITGB3/PDGFB/IBSP/ITGA3	1.94097175123601
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	40/2020	142/9376	1.30748849532841	UBE2L6/SOCS3/BIRC3/UBE2D1/UBE2E2/UBE2R2/XIAP/HERC1/CBL/SMURF2/UBC/UBE3A/PIAS1/UBE2D3/BIRC6/STUB1/PML/UBE2W/BIRC2/UBA6/UBE2D4/TRIP12/UBE2B/UBE4A/UBA7/UBR5/UBE2Q1/UBE2Z/DDB2/UBE2J1/SOCS1/FBXW11/ITCH/SYVN1/UBE3B/MGRN1/WWP2/TRAF6/RHOBTB2/NHLRC1	1.93472200408357
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	15/2020	44/9376	1.58235823582358	HEXB/HEXA/MGAT1/MGAT4A/MAN1A1/RPN1/MGAT4B/STT3B/MAN1B1/MGAT2/MAGT1/ALG2/ALG13/ALG1/MAN2A2	2.02894211784007
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	29/2020	98/9376	1.37353000606183	NR4A2/ATP1B3/ATP2B1/CAMK1D/PRKACB/CAMK1/ATP1B1/ADCY7/CAMK2D/ITPR1/GNAQ/NR4A1/ADCY3/PLCB2/SCARB1/CREB3L2/ORAI1/ATP1A1/CREB5/KCNJ5/POMC/CREB3/PRKACA/ATF6B/CREB1/DAGLB/PRKCB/CAMK1G/DAGLA	1.94783341239607
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	32/2020	110/9376	1.35027902790279	IFNGR2/HMOX1/IFNGR1/CDKN1A/HIF1A/NFKB1/TFRC/VEGFA/SERPINE1/PFKFB3/CYBB/HK3/TLR4/STAT3/IL6R/CAMK2D/MAPK1/PIK3R1/LTBR/CREBBP/PLCG2/HK2/BCL2/EP300/PIK3CA/MAP2K1/PRKCB/PIK3CD/TIMP1/ENO3/IL6/EDN1	1.93644333527138
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	7/2020	16/9376	2.03069306930693	HEXB/HEXA/GLA/GBGT1/NAGA/ST3GAL1/ST3GAL2	2.16218019659176
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	16/2020	48/9376	1.54719471947195	ALDH2/IL4I1/ACAA2/HADHB/ALDH3A2/BCAT1/HADHA/HMGCL/ACADM/ACAA1/ACAT1/ACADS/ACSF3/MCCC1/ABAT/BCKDHA	1.99163023335393
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/2020	30/9376	1.70191419141914	PIGT/B3GALT4/PIGP/GPAA1/MPPE1/PIGH/PIGQ/PIGM/PGAP3/PIGZ/PIGA	2.01777262083985
NA	NA	hsa04517	IgSF CAM signaling	77/2020	299/9376	1.19532434848836	CD84/ITGB2/CD48/ITGAX/MSN/CD86/MBP/PTPN6/CADM1/ARPC1B/RAP1A/LCP2/RHOA/ICAM1/LYN/ARPC4/ACTR3/SLAMF7/ARPC3/ITGAM/DOK2/TUBA1A/NRP2/CSK/DOK1/NCK1/ACTR2/GRB2/ITGAL/RAP1B/EPB41L2/PMP22/PPFIA1/CRTAM/VAV1/MAPK1/ARPC2/PIK3R1/EPB41L3/ICAM2/RAPGEF2/IQGAP1/TRIO/PAK1/GLDN/INPP5D/ACTB/SPTAN1/LRFN4/TUBB2A/ITGA4/PLCG2/PLXNA1/BAIAP2/PAK2/SRC/RAC1/PIK3CA/MAP2K1/CD80/PRKCB/PIK3CD/MYL6/FOXO1/TRAF6/EPB41L1/UNC5B/TUBA4A/LY9/MAPK8/PLXNA3/SRGAP3/CASK/ITGB3/MAG/ROBO3/SLAMF6	1.79871051487849
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	26/2020	88/9376	1.37137713771377	C5AR1/PLAUR/SERPINA1/ITGB2/ITGAX/A2M/CFD/C3AR1/C1QB/C3/C1QA/C2/C1QC/SERPINE1/ITGAM/SERPING1/CD46/PLAU/CD59/THBD/SERPINE2/CR1/PROC/SERPINF2/F8/CR1L	1.83415426508645
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	13/2020	38/9376	1.58791036998437	HEXB/HEXA/GNPDA1/RENBP/HK3/NAGK/AMDHD2/CHIT1/UAP1L1/HK2/FPGT/GNPDA2/UAP1	1.90290210617832
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2020	38/9376	1.58791036998437	NAMPT/BST1/SIRT2/CD38/NNT/NADK/NT5C2/NADSYN1/SIRT7/NMNAT1/SIRT1/SARM1/NMNAT3	1.90290210617832
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	13/2020	38/9376	1.58791036998437	PTPRC/CD4/TAP1/BTK/IL2RG/CD40/CIITA/IL7R/ORAI1/IKBKG/BLNK/RFX5/JAK3	1.90290210617832
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	14/2020	42/9376	1.54719471947195	ALDH2/IL4I1/AOC1/CAT/KYNU/ALDH3A2/CYP1B1/HADHA/KMO/ACAT1/HAAO/AFMID/TDO2/IDO1	1.86240061883553
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	26/2020	89/9376	1.35596840582935	MAP3K2/GNAI2/TUBA1A/PRKACB/GRB2/ADCY7/MAPK1/ITPR1/KRAS/GNAQ/ADCY3/PLCB2/SOS2/TUBB2A/SOS1/PRKACA/CSNK1D/SRC/NRAS/MAP2K1/LPAR1/PRKCB/PDGFC/MAPK7/TUBA4A/PDGFB	1.76810965967332
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	29/2020	103/9376	1.30685379217533	ITGB2/CXCL2/FN1/CXCL3/HSPB1/NFKB1/ITGAM/PRKACB/TLR4/RAB5C/GNA15/TLR2/RAB7A/IL10/GNAQ/PIK3R1/TGFB1/PLCB2/IL1B/RAB5A/PRKACA/CD1D/PIK3CA/LAMB3/PRKCB/PIK3CD/PRDX1/IL6/TGFB2	1.6408936708117
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	28/2020	99/9376	1.31277127712771	JUN/CDKN1A/NOTCH2/HBEGF/FOS/MMP9/PRKACB/BAX/GRB2/ADCY7/MAPK1/KRAS/PIK3R1/ADCY3/NCOR1/SOS2/SOS1/PRKACA/BCL2/SRC/NRAS/PIK3CA/MAP2K1/NOTCH1/PIK3CD/ARAF/MAPK8/JAG1	1.63938570972766
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	19/2020	63/9376	1.399842841427	ALDH2/COLGALT1/KMT2E/SETDB2/ALDH3A2/HADHA/PLOD3/KMT2C/KMT2A/ACAT1/PHYKPL/PRDM2/KMT2B/ASH1L/TMLHE/EZH1/SETD1B/DOT1L/PIPOX	1.66861160964733
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	23/2020	79/9376	1.3513472866274	ATP6V0D1/ATP6V0B/ATP6V1F/ATP6V0E1/TCIRG1/ATP6V1B2/SLC1A3/ATP6V1A/ATP6V1D/NAPA/ATP6V1G1/ATP6V1C1/ATP6V0A1/ATP6V1H/AP2S1/NSF/AP2B1/STX3/ATP6V0D2/SLC6A12/ATP6V0A2/ATP6V0C/CACNA1A	1.64330885983636
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	45/2020	170/9376	1.2286546301689	GADD45B/HMOX1/GSTO1/NFE2L2/MGST1/CDKN1A/MGST2/TGFBR1/TGFBR2/BAX/HGF/GRB2/APC/MAPK1/KRAS/BCL2L1/PIK3R1/TGFB1/PBRM1/GSTT1/GADD45G/SOS2/BAK1/ACTB/TXNRD1/POLK/SOS1/SMARCC2/PLCG2/DDB2/SMAD2/ARID1B/CDK6/NRAS/PIK3CA/MAP2K1/PRKCB/PIK3CD/GSTM4/FRAT1/ARAF/FZD2/ELK1/SMARCD3/TGFB2	1.57655613233424
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/2020	56/9376	1.40905233380481	MGAT1/MGAT4A/MAN1A1/SRD5A3/RPN1/MGAT4B/STT3B/MAN1B1/ALG5/MGAT2/MAGT1/ALG2/ALG13/DPAGT1/ALG1/ST6GAL1/MAN2A2	1.60881236237931
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/2020	37/9376	1.50537864597271	IL18/ICAM1/IL10/MYD88/GNAQ/PLCB2/IL1B/APOL1/FAS/PRKCB/IL6/IDO1	1.61401670178715
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	13/2020	41/9376	1.47172180632697	TYMP/CDKN1A/HBEGF/MMP9/VEGFA/DAPK1/MAPK1/KRAS/SRC/NRAS/MAP2K1/RASSF1/ARAF	1.58621182345164
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	50/2020	195/9376	1.19014978420919	FCGR3A/C5AR1/NCF2/ITGB2/FPR3/CYBA/AQP9/FCGR1A/C3/NFKB1/SYK/CASP1/CLEC7A/ITGAM/CYBB/TLR4/ATG7/SIGLEC9/CASP4/FCGR2A/TLR2/FPR1/ITGAL/SELPLG/NCF4/RAC2/NCF1/MAPK1/TLR7/PPIF/PIK3R1/TLR8/PLCB2/ACTB/PLCG2/SRC/RAC1/HDAC10/CR1/PIK3CA/MAP2K1/CAMP/HDAC7/PRKCB/PIK3CD/ITGB3/HDAC4/FCGR3B/FPR2/CR1L	1.40607540456842
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	14/2020	47/9376	1.3825995365494	SOCS3/HK3/MAPK1/PIK3R1/PRKCD/IRS2/HK2/IKBKB/SOCS1/PIK3CA/PIK3CD/SOCS4/MAPK8/CACNA1A	1.37789550917777
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2020	20/9376	1.62455445544554	NPL/CYB5R4/CYB5R3/NANS/UAP1L1/UAP1/NANP	1.46514519376973
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	59/2020	238/9376	1.1506448123804	C5AR1/STAT1/JUN/NFKBIA/CFD/C3AR1/C1QB/C3/HBEGF/C1QA/JAK1/FOS/NFKB1/C2/OAS1/SYK/CASP1/C1QC/IFNAR1/TNFRSF1A/CYBB/STAT2/TLR4/IFIH1/STAT3/FCGR2A/IL6R/IRAK1/ADAM17/OAS2/TLR2/MX2/MYD88/TRAF3/MAPK1/TLR7/PIK3R1/TAB2/IFNAR2/TLR8/MX1/IL1B/ADAR/CXCL10/IKBKG/IRAK4/PLCG2/IKBKE/IKBKB/PIK3CA/PRKCB/NLRP3/NFKBIB/PIK3CD/CHUK/TRAF6/ACE/MAPK8/IL6	1.23355223690794
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/2020	60/9376	1.31511551155116	GNAI2/GNA13/LYN/MAPK1/ITPR1/KRAS/GNAQ/PLCB2/GNA12/PLA2G4C/NRAS/MAP2K1/PRKCB/PLA2G4A/ARAF/CACNA1A/CRH	1.28313139066355
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	24/2020	89/9376	1.25166314384247	GLUL/GNAI2/GABARAP/GABARAPL1/GNB4/PRKACB/GABARAPL2/GLS/ADCY7/ADCY3/GNGT2/PRKACA/GNB1/NSF/TRAK2/SRC/SLC38A2/GNG7/PRKCB/SLC6A12/ABAT/PLCL1/GABBR1/CACNA1A	1.25002114885711
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	56/2020	226/9376	1.15012704810304	JUN/GNAI2/NFKBIA/ATP1B3/ATP2B1/RRAS/RAP1A/FOS/RHOA/NFKB1/PRKACB/ATP1B1/ROCK1/ADCY7/RAC2/RAP1B/PDE4B/VAV1/CAMK2D/SUCNR1/MAPK1/PIK3R1/ADCY3/HCAR3/ATP2A2/PDE4A/CREB3L2/HCAR2/PAK1/ORAI1/CREBBP/ATP1A1/PTGER2/CREB5/POMC/CREB3/TIAM1/PRKACA/PLD1/ACOX1/PLD2/RAC1/EP300/CREB1/PIK3CA/MAP2K1/PIK3CD/PDE3B/MAPK8/NFATC1/GRIN3A/ARAP3/GABBR1/ATP2A3/EDN1/CRH	1.19713486838844
NA	NA	hsa03272	Virion - Hepatitis viruses	14/2020	48/9376	1.35379537953795	CD9/CHMP1B/LAMP2/CD81/CD63/LAMP1/TGOLN2/PDCD6IP/SCARB1/CHMP4A/CHMP4B/IST1/CLDN23/CLDN1	1.28771267198758
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	6/2020	17/9376	1.63820617355853	CYP27A1/HSD3B7/HSD17B4/SCP2/ACOX2/CH25H	1.380102048897
Human Diseases	Cancer: specific types	hsa05218	Melanoma	20/2020	73/9376	1.27166689271667	GADD45B/MITF/CDKN1A/BAX/HGF/MAPK1/KRAS/PIK3R1/GADD45G/BAK1/POLK/DDB2/CDK6/NRAS/PIK3CA/MAP2K1/PDGFC/PIK3CD/ARAF/PDGFB	1.2210321456808
Organismal Systems	Endocrine system	hsa04924	Renin secretion	19/2020	69/9376	1.27811737695509	CTSB/GNAI2/PTGER4/PRKACB/KCNMA1/ITPR1/GNAQ/PLCB2/ORAI1/KCNJ2/PTGER2/PRKACA/CREB1/PPP3CB/PDE3B/PPP3CC/ACE/PDE1B/EDN1	1.21503356609012
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	18/2020	65/9376	1.28536176694593	NCEH1/PRKACB/ADCY7/ITPR1/GNAQ/NR4A1/ADCY3/PLCB2/SCARB1/CREB3L2/ORAI1/CREB5/POMC/CREB3/PRKACA/ATF6B/PDE8A/CREB1	1.20974758304921
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	28/2020	107/9376	1.21462015360415	FBP1/SIK1/PRKAG2/PRKACB/PCK2/CPT1A/CAMK2D/ITPR1/GNAQ/PLCB2/CREB3L2/CREBBP/CREB5/CREB3/PRKACA/PYGB/PRKAA1/G6PC3/EP300/CREB1/SIK2/PPP3CB/PDE3B/FOXO1/SIRT1/CRTC2/PPP3CC/ACACB	1.17000148175637
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/2020	21/9376	1.54719471947195	ALDH2/DPYD/ALDH3A2/BCAT1/VNN2/DPYS/CSAD	1.31543717710882
Organismal Systems	Digestive system	hsa04978	Mineral absorption	17/2020	61/9376	1.29355624086999	HMOX1/SLC8A1/FTL/FTH1/ATOX1/ATP1B3/ATP2B1/SLC31A1/ATP1B1/SLC30A1/VDR/SLC11A2/CYBRD1/ATP1A1/ATP7A/TRPM7/SLC46A1	1.20532806333056
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	14/2020	49/9376	1.32616690240453	JUN/GNAI2/NFKB1/FOSB/PRKACB/CREB3L2/CDK5/CREB5/CREB3/PRKACA/ATF6B/CREB1/DLG4/GRIN3A	1.19951975123455
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	13/2020	45/9376	1.34090209020902	ABCA1/ABCC3/TAP1/ABCG1/ABCD1/ABCB7/ABCC5/ABCB8/ABCD4/ABCC1/ABCA5/ABCC10/ABCA2	1.20119160662289
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	92/2020	388/9376	1.1005818107584	APOE/LRP1/LPL/RTN4/RTN3/BID/NFKB1/ADAM10/TUBA1A/APH1B/SLC39A11/TNFRSF1A/CYBB/APH1A/ADAM17/SDHB/PSENEN/ERN1/NCSTN/APC/MAPK1/ITPR1/PSEN1/SDHD/KRAS/SLC11A2/PPIF/GNAQ/PIK3R1/RB1CC1/ATF6/PSEN2/PLCB2/SLC39A3/ATP2A2/IL1B/MT-ND4L/MT-ND2/CDK5/SNCA/BECN1/NDUFB9/NDUFB5/CAPN2/IRS2/MAP3K5/IKBKG/NRBF2/CASP8/CYCS/PSMD9/TUBB2A/CSF1/PTGS2/SLC39A13/KIF5B/SLC39A8/IKBKB/MT-CO1/DDIT3/NRAS/PIK3CA/CASP7/MAP2K1/FAS/EIF2AK3/ATG2A/PPP3CB/BACE1/UQCRB/PIK3CD/CHUK/PIK3C3/MCU/FRAT1/ARAF/FZD2/PPP3CC/ATG14/MAP2K7/TUBA4A/MAPK8/CASP9/PSMA6/MT-ND3/AMBRA1/PIK3R4/ULK2/MT-ATP8/IL6/IL1A/ATP2A3	1.06033779902158
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	20/2020	75/9376	1.23775577557756	GPX1/ATP1B3/ASGR1/PRKACB/ATP1B1/ADCY7/ITPR1/GNAQ/ADCY3/PLCB2/CREB3L2/CANX/ATP1A1/CREB5/CREB3/PRKACA/ATF6B/CREB1/PRKCB/PAX8	1.08327157591418
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2020	18/9376	1.54719471947195	ACSL1/ACSL3/ACSL5/ACSL6/ACSF3/ACACB	1.21766295161592
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/2020	22/9376	1.47686768676868	ALDH2/HNMT/AOC1/ALDH3B1/ALDH3A2/CNDP2/AMDHD1	1.17341332400893
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	8/2020	26/9376	1.42817974105103	TCN2/SCARB1/LMBRD1/SLC19A2/BTD/ABCD4/SLC46A1/ABCC1	1.14563809477709
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	41/2020	166/9376	1.14641536442801	RGS2/SLC8A1/GNAI2/ATP1B3/GNA13/ATP2B1/RHOA/MEF2A/PIK3R5/ATP1B1/ROCK1/ADCY7/KCNMA1/MAPK1/ITPR1/PPIF/GNAQ/ADCY3/PLCB2/ATP2A2/CREB3L2/VASP/KCNMB1/IRS2/GTF2I/GNA12/MEF2D/ATP1A1/CREB5/NFATC3/CREB3/ATF6B/CREB1/MAP2K1/PPP3CB/PDE3B/PIK3CG/PIK3R6/PPP3CC/NFATC1/ATP2A3	0.997358617232108
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	16/2020	59/9376	1.25873468702802	GNAI2/MGLL/PRKACB/PTGS1/FABP4/ADCY7/PIK3R1/ADCY3/PNPLA2/IRS2/ABHD5/PTGS2/PRKACA/PIK3CA/PIK3CD/PDE3B	1.04467950987232
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/2020	93/9376	1.19782816991377	PTPN6/RAP1A/RHOA/WAS/TGFBR1/TGFBR2/ROCK1/SMURF2/RAC2/RAP1B/MAPK1/IQGAP1/PTPN1/CREBBP/ACTB/WASF2/PTPRJ/BAIAP2/SRC/RAC1/EP300/MYL5/PTPRM/SNAI1	1.00467569294197
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	45/2020	184/9376	1.135170038743	CXCR4/PLXNC1/GNAI2/RRAS/RHOA/DPYSL2/LIMK1/SEMA3C/NCK1/ROCK1/SEMA4A/RAC2/CAMK2D/MAPK1/KRAS/PIK3R1/SSH1/PLXNB2/CDK5/BMPR2/EPHB6/PAK1/EPHB2/NFATC3/CFL1/SSH2/PLCG2/PLXNA1/PAK2/SRC/RAC1/NRAS/PIK3CA/PPP3CB/PIK3CD/PPP3CC/SEMA6B/UNC5B/PLXNA3/MYL5/SEMA3A/SRGAP3/SEMA4D/LRIG2/ROBO3	0.970341943951849
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	14/2020	51/9376	1.27416035721219	PLD3/PLA2G7/LPCAT2/TMEM86A/AGPS/CEPT1/PLA2G4C/PLD1/PLD2/PAFAH1B2/PLD4/PLA2G4A/PAFAH2/LPCAT4	1.02874038161156
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/2020	56/9376	1.24328147100424	ARRB2/PRKACB/SMURF2/SPOP/SPOPL/ARRB1/PRKACA/CSNK1D/BCL2/CSNK1G1/FBXW11/MGRN1/MEGF8/SUFU/PTCH2	0.956831695467638
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/2020	23/9376	1.41265604821352	CTSA/ATP6AP2/ANPEP/PRCP/LNPEP/NLN/ACE	1.03828631127799
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	13/2020	48/9376	1.25709570957096	ATP1B3/HK3/ATP1B1/PIK3R1/PLCB2/ATP1A1/HK2/G6PC3/SLC2A5/PIK3CA/PRKCB/PIK3CD/AMY2B	0.935753891304409
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	17/2020	65/9376	1.21395277989337	SPP1/ARRB2/MAPK1/ITPR1/KRAS/GNAQ/PIK3R1/PLCB2/KCNN4/ARRB1/KCNJ5/NRAS/PIK3CA/MAP2K1/PRKCB/PIK3CD/GABBR1	0.907020099899069
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/2020	36/9376	1.28932893289329	GALNT7/ST6GALNAC4/B4GALT5/GALNT6/ST3GAL1/GALNT11/GALNT10/GCNT1/ST3GAL2/GALNT12	0.911402341867252
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/2020	12/9376	1.54719471947195	ASGR1/CD46/NPC1/FCGR2B	0.993899062298954
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	25/2020	102/9376	1.13764317608231	ATP1B3/ATP2B1/RAP1A/RHOA/BST1/ATP1B1/ADCY7/RAP1B/KCNMA1/ITPR1/GNAQ/ADCY3/PLCB2/ATP2A2/CD38/SLC4A2/ATP1A1/RAC1/KCNQ1/PRKCB/TPCN2/RAB3D/SLC12A2/ATP2A3/AMY2B	0.732422518035119
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	32/2020	133/9376	1.11677212834065	GNAI2/ARRB2/GNB4/FOS/PRKACB/CAMK2D/ITPR1/GNAQ/PLCB2/CREB3L2/GNGT2/PPP2R3C/PPP2R5C/ARRB1/CREB5/KCNJ5/CREB3/PRKACA/KIF5B/GNB1/ATF6B/PPP2R5A/CREB1/GNG7/PPP3CB/PRKCB/CLOCK/PPP2R2D/PPP3CC/MAPK8/PPP2R5B/CACNA1A	0.710720762052118
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	16/2020	63/9376	1.17881502435958	LTA4H/ALOX5/TBXAS1/PTGS1/CBR1/GPX4/PTGS2/PLA2G4C/HPGD/ALOX15B/PLA2G4A/CBR3/AKR1C3/GGT1/CYP2U1/PTGR2	0.746225253304275
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	8/2020	29/9376	1.28043700921816	RASSF4/MOB1A/RASSF2/PAK1/MOB1B/NF2/RASSF1/LATS2	0.792571893378426
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/2020	59/9376	1.18006376908877	GSTO1/GPX1/ANPEP/MGST1/LAP3/MGST2/GSTK1/GPX4/RRM2B/GSTT1/TXNDC12/GCLC/G6PD/GSTM4/GGT1	0.72703406024971
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	109/2020	480/9376	1.05402640264026	UBE2L6/GPX1/SQSTM1/PRNP/CAT/BID/NFKB1/ATXN1/TUBA1A/TNFRSF1B/TNFRSF1A/CYBB/MAP1LC3B/BAX/SDHB/DERL1/UBC/C9orf72/ERN1/CAMK2D/TANK/APC/MAPK1/ITPR1/PSEN1/SDHD/KRAS/BCL2L1/PPIF/LRRK2/GNAQ/PINK1/RB1CC1/ATF6/PSEN2/PLCB2/ATP2A2/IL1B/MT-ND4L/MT-ND2/CDK5/SNCA/BECN1/NDUFB9/FIG4/NDUFB5/CAPN2/WDR41/BAK1/MAP3K5/SPG11/NRBF2/CASP8/CYCS/PSMD9/RAB5A/ACTR1A/TUBB2A/CSF1/PTGS2/UBA7/RAB1A/KIF5B/MAP2K3/UBE2J1/HTT/BCL2/ATXN3/RAC1/MT-CO1/DDIT3/NRAS/CASP7/MAP2K1/FAS/EIF2AK3/ATG2A/PPP3CB/DCTN4/PRKCB/ACTR1B/UQCRB/TOMM40L/PIK3C3/MCU/FRAT1/ARAF/DLG4/FZD2/PPP3CC/ATG14/MAP2K7/TUBA4A/ATXN1L/MAPK8/CASP9/MFN2/PSMA6/ZFYVE1/MT-ND3/AMBRA1/PIK3R4/ULK2/MT-ATP8/IL6/ALS2/IL1A/DNAH17/ATP2A3	0.636751160450461
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	28/2020	116/9376	1.12038238306589	GLUL/GNAI2/HOMER3/GNB4/SLC1A3/PRKACB/GLS/ADCY7/MAPK1/ITPR1/GNAQ/ADCY3/PLCB2/GNGT2/PRKACA/PLA2G4C/GNB1/PLD1/PLD2/SLC38A2/GNG7/PPP3CB/PRKCB/PLA2G4A/DLG4/PPP3CC/GRIN3A/CACNA1A	0.683639110124004
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	40/2020	170/9376	1.09213744903902	MSN/JUN/ARPC1B/RAP1A/RHOA/RAB13/ARPC4/WAS/ACTR3/PRKAG2/ARPC3/TUBA1A/HCLS1/PRKACB/ACTR2/ROCK1/ARHGEF2/YBX3/ARPC2/RAPGEF2/VASP/MAP3K5/ACTB/TIAM1/PRKACA/CLDN23/CD1D/PRKAA1/SRC/RAC1/NF2/ARHGEF18/MYL6/PPP2R2D/WHAMM/MAP2K7/TUBA4A/MAPK8/MICALL2/CLDN1	0.635280642219248
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	10/2020	38/9376	1.22146951537259	SGK1/ATP1B3/ATP1B1/MAPK1/KRAS/PIK3R1/ATP1A1/PIK3CA/PRKCB/PIK3CD	0.716835131293908
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/2020	17/9376	1.36517181129878	PAPSS1/PAPSS2/SEPHS2/TXNRD1/SEPSECS	0.78967328404674
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/2020	47/9376	1.18508531704234	ALDH2/ME2/AKR1A1/PCK2/ALDH3A2/ACYP2/ACAT1/ME3/ME1/ACSS2/LDHD/ACACB	0.666567004935354
Human Diseases	Substance dependence	hsa05032	Morphine addiction	22/2020	91/9376	1.12214122511152	GNAI2/ARRB2/GNB4/PRKACB/ADCY7/PDE4B/ADCY3/PDE4A/GNGT2/ARRB1/KCNJ5/PRKACA/PDE7A/GNB1/PDE8A/GNG7/PRKCB/PDE3B/PDE1B/GABBR1/GRK4/CACNA1A	0.613525300096628
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/2020	69/9376	1.14357870569666	JUN/FOS/FOSB/PRKACB/CAMK2D/CREB3L2/CREB5/CREB3/PRKACA/ATF6B/CREB1/PPP3CB/PRKCB/SIRT1/PPP3CC/GRIN3A/ARC	0.627263742766367
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/2020	18/9376	1.28932893289329	TCN2/LMBRD1/ABCD4/THAP11/PRDX1	0.64383867365297
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/2020	31/9376	1.19782816991377	GLUL/CAT/ACO2/ACAT1/CS/ACSS2/AFMID/GLYCTK	0.578122390916611
NA	NA	hsa04981	Folate transport and metabolism	8/2020	31/9376	1.19782816991377	ABCC3/SLCO2B1/MTHFR/FPGS/ABCC5/FOLR3/SLC46A1/ABCC1	0.578122390916611
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/2020	93/9376	1.09800915575429	LYZ/CST3/ATP1B3/ATP2B1/BST1/PRKACB/ATP1B1/ADCY7/KCNMA1/ITPR1/GNAQ/ADCY3/PLCB2/CD38/KCNN4/SLC4A2/ATP1A1/PRKACA/CAMP/PRKCB/SLC12A2/AMY2B	0.497742139125165
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/2020	53/9376	1.13850177470577	SLC8A1/ATP1B3/ATP2B1/PRKACB/ATP1B1/VDR/GNAQ/PLCB2/AP2S1/ATP1A1/PRKACA/AP2B1/PRKCB	0.529853605147208
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	53/2020	233/9376	1.0558109888242	ZYX/VIM/FMNL2/FN1/SDC2/ATP1B3/FMNL1/TLN1/PDLIM7/PLEC/ITGAV/FHL3/CAPZA2/ATP1B1/SDC3/SNTB1/LMNA/FMNL3/AMPD3/ITGA6/ITGB5/SUN2/ACTB/SPTAN1/ITGB7/AMPD2/THBS3/ATP1A1/SYNE1/CAPZA1/ITGA4/PDLIM5/MYOZ1/DIAPH1/CAPZB/DIAPH2/AGRN/TMEM43/SNTB2/FBN1/COL9A2/ENO3/TMOD2/PDLIM4/MYL5/BGN/MYOM2/TLN2/ITGB3/CAPN3/ITGA3/CKM/FHL1	0.45205760562628
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/2020	27/9376	1.2033736707004	HSD17B4/SCP2/ACOT2/ACAA1/ELOVL1/HSD17B12/ACOX1	0.554542060940912
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	12/2020	49/9376	1.13671448777531	LFNG/COLGALT1/GALNT7/MFNG/PLOD3/GALNT6/RFNG/GALNT11/GALNT10/ST6GAL1/FUT11/GALNT12	0.502784700585611
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	18/2020	76/9376	1.09932256383533	GNAI2/ATP1B3/PRKACB/ATP1B1/ADCY7/CAMK2D/ITPR1/GNAQ/ADCY3/PLCB2/SLC4A2/KCNJ2/ACTB/ATP1A1/PRKACA/KCNQ1/PRKCB/HRH2	0.455568519559934
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/2020	36/9376	1.16039603960396	GAA/HK3/GYG1/PYGB/HK2/G6PC3/PGM2L1/GANC/AMY2B	0.505256507392568
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	33/2020	144/9376	1.06369636963696	ATXN1/ERN1/ITPR1/PPIF/GNAQ/PIK3R1/RB1CC1/PLCB2/ATP2A2/BECN1/MAP3K5/NRBF2/CYCS/PSMD9/ATXN3/PIK3CA/ATG2A/PRKCB/PIK3CD/PIK3C3/MCU/KCNC3/CIC/ATG14/ATXN1L/MAPK8/PSMA6/GRIN3A/AMBRA1/PIK3R4/ULK2/CACNA1A/ATP2A3	0.403634696591187
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	23/2020	99/9376	1.07834783478348	PTGER4/TRPV2/PRKACB/ADCY7/CAMK2D/ITPR1/GNAQ/PIK3R1/ADCY3/PLCB2/IL1B/PRKCD/PTGER2/PRKACA/PLCG2/PLA2G4C/MAP2K3/SRC/PIK3CA/PRKCB/PIK3CD/PLA2G4A/MAPK8	0.410658938735259
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/2020	32/9376	1.16039603960396	GAA/GLA/GALM/GLB1/HK3/HK2/G6PC3/GANC	0.47625843187086
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/2020	32/9376	1.16039603960396	HADHA/ACADS/ACOX1/MLYCD/ACSS2/ABAT/ACACB/BCKDHA	0.47625843187086
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/2020	59/9376	1.10139285114952	TYMP/UPP1/DPYD/TK2/DCTD/ENTPD1/RRM2B/NT5C2/NT5C3A/CDA/CMPK2/NME7/DPYS/AK9	0.409388610627097
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	35/2020	154/9376	1.05490549054905	SLC8A1/GNAI2/ATP1B3/ATP2B1/PRKACB/PIK3R5/ATP1B1/ADCY7/CAMK2D/MAPK1/GNAQ/ADCY3/PLCB2/ATP2A2/CREB3L2/PPP2R3C/PPP2R5C/ATP1A1/CREB5/CREB3/PRKACA/CACNA2D4/BCL2/ATF6B/PPP2R5A/KCNE1/CREB1/CREM/KCNQ1/PPP2R2D/PIK3CG/PIK3R6/PPP1R1A/PPP2R5B/ATP2A3	0.360001276074093
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/2020	28/9376	1.16039603960396	PPT1/ACAA2/HADHB/HADHA/ACOT2/ELOVL1/HSD17B12	0.445403645421951
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/2020	78/9376	1.07113480578827	FN1/RHOG/ARPC1B/RHOA/ARPC4/ACTR3/ARPC3/HCLS1/ACTR2/CBL/ARPC2/PIK3R1/ACTB/WASF2/SRC/RAC1/PIK3CA/PIK3CD	0.330578909880953
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	23/2020	101/9376	1.05699441231252	GNAI2/MITF/PRKACB/ADCY7/CAMK2D/MAPK1/KRAS/GNAQ/ADCY3/PLCB2/CREB3L2/CREBBP/POMC/CREB3/PRKACA/EP300/CREB1/NRAS/MAP2K1/ASIP/PRKCB/FZD2/EDN1	0.301770283074779
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/2020	52/9376	1.07113480578827	ALOX5/PRKACB/ADCY7/CYP1B1/ACOT2/ADCY3/SCARB1/PTGS2/PRKACA/PLA2G4C/PLA2G4A/AKR1C3	0.269539955402142
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	22/2020	99/9376	1.03146314631463	SLC8A1/PRKAG2/ITGAV/SNTB1/LMNA/TGFB1/ATP2A2/ITGA6/ITGB5/ACTB/ITGB7/ITGA4/CACNA2D4/PRKAA1/SNTB2/ACE/ITGB3/IL6/ITGA3/ATP2A3/EDN1/TGFB2	0.164913584536779
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/2020	35/9376	1.06093352192362	FBP1/HSD17B14/PFKFB3/HK3/SORD/HK2/PFKFB2/FPGT	0.189249211892594
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	19/2020	86/9376	1.02546626755699	ATP1B3/PRKACB/ATP1B1/ADCY7/KCNMA1/CAMK2D/GNAQ/ADCY3/PLCB2/CREB3L2/KCNN4/KCNMB1/ATP1A1/CREB5/CREB3/PRKACA/ATF6B/CREB1/PRKCB	0.124321754030057
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	18/2020	82/9376	1.01888432745714	TYMP/UPP1/GSTO1/MGST1/DPYD/GUSB/MGST2/TK2/IMPDH1/RRM2B/GSTT1/TPMT/CDA/GSTM4/CES2/CES1/NME7/DPYS	0.0900010502361128
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/2020	31/9376	1.04809964867454	FBP1/H6PD/G6PD/PRPS2/RBKS/IDNK/GLYCTK	0.140563823170877
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/2020	17/9376	1.09213744903902	GGT1/FMO4/CSAD/FMO5	0.199244519196482
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/2020	17/9376	1.09213744903902	LAMP2/LAMP1/TFRC/NRP2	0.199244519196482
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	25/2020	115/9376	1.00904003443823	DUSP1/GNAI2/ALOX5/GNB4/PRKACB/PTGS1/MAPK1/ITPR1/KRAS/GNAQ/PLCB2/GNGT2/PTGS2/KCNJ5/PRKACA/PLA2G4C/GNB1/NRAS/MAP2K1/GNG7/PRKCB/ALOX15B/PLA2G4A/ARAF/CACNA1A	0.0511129003962286
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	25/2020	116/9376	1.00034141345169	FBP1/SDS/ME2/SDSL/CAT/ADPGK/HK3/SDHB/SDHD/H6PD/ACO2/ACAT1/OGDH/ME3/ACADS/ME1/G6PD/HK2/PRPS2/ACOX1/CS/IDNK/ACSS2/ENO3/GLYCTK	0.00193885170199656
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	59/2020	275/9376	0.995830783078308	NCF2/HSPA1B/HSPA1A/CYBA/PRNP/C1QB/C1QA/C1QC/TUBA1A/CYBB/PRKACB/BAX/SDHB/NCF4/RAC2/NCF1/MAPK1/HSPA6/ITPR1/SDHD/PPIF/PIK3R1/CREB3L2/IL1B/MT-ND4L/MT-ND2/NDUFB9/PRKCD/NDUFB5/CYCS/PSMD9/TUBB2A/CREB5/CREB3/CCL5/PRKACA/KIF5B/ATF6B/RAC1/CREB1/MT-CO1/DDIT3/PIK3CA/EIF2AK3/NOTCH1/PPP3CB/UQCRB/PIK3CD/MCU/PPP3CC/TUBA4A/MAPK8/CASP9/PSMA6/MT-ND3/GRIN3A/MT-ATP8/IL6/IL1A	-0.0367719570470609
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/2020	27/9376	1.03146314631463	HADHA/HMGCL/ACAT1/ACADS/ACSM5/ABAT	0.0857910364744506
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/2020	13/9376	1.07113480578827	LIG4/POLL/POLM	0.134489003983502
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/2020	37/9376	1.0035857639818	HK3/NAGK/NANS/UAP1L1/HK2/FPGT/UAP1/NANP	0.0114517758148617
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	33/2020	155/9376	0.988208240178857	NCEH1/GNAI2/CDKN1A/AHR/RAP1A/PRKACB/ADCY7/RAP1B/CAMK2D/APC/MAPK1/ITPR1/GNAQ/NR4A1/ADCY3/PLCB2/KMT2A/SCARB1/CREB3L2/ORAI1/USP8/CREB5/POMC/CREB3/PRKACA/CDK6/ATF6B/PDE8A/CREB1/MAP2K1/FZD2/CDKN2B/CRH	-0.0775703811591647
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	54/2020	254/9376	0.986793482497856	CXCR4/SLC8A1/VEGFB/ATP2B1/ORAI2/P2RX4/PTAFR/P2RX7/VEGFA/MCOLN1/SPHK1/ORAI3/CAMK1D/PRKACB/CAMK1/HGF/GNA15/TFEB/ADCY7/CAMK2D/TPCN1/ITPR1/PPIF/GNAQ/ADCY3/PLCB2/ATP2A2/CD38/ORAI1/PTK2B/NFATC3/PRKACA/PLCG2/ITPKB/MCOLN3/PPP3CB/PRKCB/STIM2/TPCN2/PDGFC/STIM1/MCU/HRH2/CAMK1G/PPP3CC/ADORA2B/SPHK2/MCOLN2/NFATC1/GRIN3A/PDE1B/PDGFB/CACNA1A/ATP2A3	-0.111815136487044
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2020	23/9376	1.00904003443823	ATP1B3/ATP1B1/PCK2/GLS/ATP1A1	0.0227456838481511
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/2020	85/9376	0.982923704135119	TYMP/UPP1/TK2/DCTD/LACC1/IMPDH1/AMPD3/ENTPD1/RRM2B/AMPD2/NT5C2/NT5C3A/CDA/GUK1/CMPK2/GMPR/NME7/AK9	-0.0828728675108439
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/2020	28/9376	0.994625176803395	PCBD1/CBR1/FPGS/SPR/AKR1C3/GCH1	-0.0149253426155504
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/2020	128/9376	0.979084158415842	PAPSS1/PAPSS2/ADCY7/PDE4B/LACC1/IMPDH1/ADCY3/PDE4A/AMPD3/ENTPD1/RRM2B/AMPD2/ENPP4/NT5C2/PDE7A/PRPS2/PDE8A/NUDT9/PDE6G/GUK1/PDE6B/PDE3B/GMPR/NME7/PDE1B/ADPRM/AK9	-0.124852395884855
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	9/2020	43/9376	0.971494358738199	CD36/ABCA1/AGPAT2/SLC27A1/SCARB1/ACAT1/DGAT1/SLC27A4/DGAT2	-0.0981736352839614
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/2020	67/9376	0.969883256982415	FBP1/ALDH2/AKR1A1/GALM/ALDH3B1/ADPGK/HK3/PCK2/ALDH3A2/HK2/G6PC3/MINPP1/ACSS2/ENO3	-0.129638605879322
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	23/2020	110/9376	0.97051305130513	GNAI2/RPS6KA1/PRKACB/ADCY7/CPEB4/MAPK1/KRAS/PIK3R1/RPS6KA3/ADCY3/RPS6KA2/STK10/PRKACA/MAD1L1/PIK3CA/MAP2K1/CPEB2/PIK3CD/PDE3B/ARAF/CPEB3/MAPK8/SPDYA	-0.163012343672244
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/2020	14/9376	0.994625176803395	B3GNT2/ST3GAL1/ST3GAL2	-0.0105459169014549
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/2020	24/9376	0.966996699669967	HS3ST1/B3GAT3/HS2ST1/B3GALT6/HS3ST2	-0.0848303396600015
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	32/2020	154/9376	0.964485019930564	ALDH2/AKR1A1/PDXK/KYNU/GUSB/DHRS3/ALDH3A2/RDH11/COQ2/BCAT1/ALAS1/KMO/HAAO/PNPO/GCLC/NADK/VKORC1/MAT2B/FPGS/MTHFD2/SPR/MAT2A/NADSYN1/NMNAT1/CMPK2/AFMID/NME7/TDO2/IDO1/AK9/GCH1/NMNAT3	-0.232862652111627
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/2020	97/9376	0.95702766152904	GNAI2/GNB4/FOS/PRKACB/ADCY7/CAMK2D/MAPK1/ITPR1/GNAQ/ADCY3/PLCB2/GNGT2/PER1/KCNJ5/PRKACA/GNB1/CREB1/GNG7/PRKCB/PER3	-0.22292805668582
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	31/2020	150/9376	0.959260726072607	GADD45B/CDKN1A/TGFBR1/TGFBR2/BAX/HGF/GRB2/APC/MAPK1/KRAS/PIK3R1/TGFB1/GADD45G/SOS2/BAK1/POLK/SOS1/DDB2/SMAD2/BCL2/RXRA/NRAS/PIK3CA/MAP2K1/PIK3CD/FRAT1/RXRB/ARAF/FZD2/CDKN2B/TGFB2	-0.263567982096636
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/2020	30/9376	0.928316831683168	SDHB/PCK2/SDHD/ACO2/OGDH/CS	-0.206065550708301
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/2020	20/9376	0.928316831683168	LIPA/SOAT1/CYP27B1/CYP2R1	-0.168161877027471
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/2020	10/9376	0.928316831683168	PAPSS1/PAPSS2	-0.118844907875348
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	42/2020	205/9376	0.95095870562666	NCF2/CTSD/CD36/CYBA/NFKB1/MMP9/TGFBR1/TGFBR2/CYBB/PDK4/SDHB/MPC1/NCF4/RAC2/NCF1/CAMK2D/SDHD/PPIF/PIK3R1/TGFB1/PLCB2/ATP2A2/MT-ND4L/MT-ND2/NDUFB9/PRKCD/NDUFB5/G6PD/SMAD2/RAC1/MT-CO1/PIK3CA/PRKCB/UQCRB/PIK3CD/PDK2/ACE/MAPK8/MT-ND3/MT-ATP8/ATP2A3/TGFB2	-0.372024010877691
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	30/2020	148/9376	0.940861653732941	GADD45B/JUN/CDKN1A/NOTCH2/FOS/BAX/GRB2/NFKB2/APC/MAPK1/KRAS/PIK3R1/GADD45G/SOS2/BAK1/POLK/SOS1/DDB2/CDK6/NRAS/PIK3CA/MAP2K1/NCOA1/NOTCH1/PIK3CD/HES1/FRAT1/ARAF/FZD2/JAG1	-0.380002718257656
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	21/2020	105/9376	0.928316831683168	SLC8A1/ITGAV/PRKACB/ADCY7/SNTB1/LMNA/TGFB1/ADCY3/ATP2A2/ITGA6/ITGB5/ACTB/ITGB7/ITGA4/PRKACA/CACNA2D4/SNTB2/ITGB3/ITGA3/ATP2A3/TGFB2	-0.387069555776427
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/2020	71/9376	0.915241946729884	HIF1A/HK3/GLS/SCO2/MAPK1/KRAS/PIK3R1/SLC16A3/G6PD/HK2/NRAS/PIK3CA/MAP2K1/PIK3CD	-0.375657809282847
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	29/2020	144/9376	0.934763476347635	ID2/KLF4/SKIL/JAK1/PCGF5/STAT3/GRB2/APC/MAPK1/KRAS/PIK3R1/BMPR2/JAK2/ZFHX3/SMAD2/NRAS/PIK3CA/MAP2K1/ACVR1/JARID2/KAT6A/PIK3CD/ACVR1B/FZD2/ACVR2A/JAK3/INHBA/SMAD1/HESX1	-0.41339443018752
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/2020	138/9376	0.908136030994404	ATP6V0D1/ATP6AP1/ATP6V0B/ATP6V1F/ATP6V0E1/TCIRG1/ATP6V1B2/ATP6V1A/ATP6V1D/ATP6V1G1/SDHB/ATP6V1C1/ATP6V0A1/SDHD/ATP6V1H/MT-ND4L/MT-ND2/NDUFB9/NDUFB5/CYCS/MT-CO1/UQCRB/ATP6V0D2/ATP6V0A2/MT-ND3/MT-ATP8/ATP6V0C	-0.569686899005385
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/2020	89/9376	0.886594726888419	SPP1/CD44/CD36/FN1/CD47/ITGAV/ITGA6/ITGB5/ITGB7/THBS3/ITGA4/LAMB3/AGRN/COL9A2/ITGB3/IBSP/ITGA3	-0.563288638999619
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/2020	28/9376	0.828854314002829	B3GNT2/ST3GAL6/B3GNT5/FUT4/FUT7	-0.475254330653052
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/2020	134/9376	0.900605881483671	GNA13/RHOA/PRKACB/ROCK1/ADCY7/KCNMA1/MAPK1/ITPR1/GNAQ/ADCY3/PLCB2/PRKCD/KCNMB1/GNA12/PRKACA/PLA2G4C/ARHGEF11/ARHGEF1/MAP2K1/PPP1R12C/PRKCB/PLA2G4A/MYL6/ARAF/ADORA2B/EDN1	-0.607254254523159
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/2020	44/9376	0.843924392439244	POLD4/MBD4/PARP4/MPG/POLG/PARP3/POLL/POLB	-0.543769031272749
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/2020	12/9376	0.773597359735974	COQ2/VKORC1	-0.411227235667722
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	74/2020	368/9376	0.933362031855359	GPX1/SQSTM1/NUP214/CAT/BID/CASP1/CHCHD10/RANBP2/TUBA1A/TNFRSF1B/TNFRSF1A/MAP1LC3B/BAX/SDHB/DERL1/C9orf72/ERN1/TANK/SETX/SDHD/BCL2L1/PINK1/RB1CC1/ATF6/ANXA11/MT-ND4L/MT-ND2/BECN1/NDUFB9/ANG/FIG4/NDUFB5/WDR41/MAP3K5/SPG11/NRBF2/CYCS/PSMD9/RAB5A/ACTB/ACTR1A/TUBB2A/RAB1A/KIF5B/MAP2K3/BCL2/RAC1/MT-CO1/DDIT3/EIF2AK3/ATG2A/PPP3CB/POM121/DCTN4/ACTR1B/UQCRB/TOMM40L/PIK3C3/MCU/PPP3CC/ATG14/TUBA4A/UBQLN4/CASP9/PSMA6/UBQLN2/POM121C/MT-ND3/AMBRA1/PIK3R4/ULK2/MT-ATP8/ALS2/DNAH17	-0.683395208928824
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	46/2020	235/9376	0.908565409732463	MGLL/ACSL1/RPS6KA1/PRKAG2/ACSL3/PRKACB/SDHB/GRB2/CPT1A/ADCY7/SLC25A20/SDHD/KRAS/RPS6KA3/ADCY3/RPS6KA2/CREB3L2/MT-ND4L/MT-ND2/NDUFB9/PNPLA2/NDUFB5/SOS2/MAP3K5/ACTB/ACSL5/CREB5/SOS1/CREB3/PRKACA/SMARCC2/MAP2K3/PRKAA1/ARID1B/CREB1/MT-CO1/SLC25A29/NRAS/KDM3A/ACSL6/UQCRB/ZNF516/TSC2/MT-ND3/MT-ATP8/SMARCD3	-0.743854616034685
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	30/2020	157/9376	0.886926909251435	ITGB2/ID2/BIRC3/SERPINE1/TGFBR1/TGFBR2/MOB1A/SMAD7/YWHAH/AREG/APC/TGFB1/BMPR2/ACTB/YWHAG/BIRC2/CSNK1D/SMAD2/TP53BP2/MOB1B/FBXW11/BBC3/NF2/RASSF1/PPP2R2D/DLG4/FZD2/LATS2/SMAD1/TGFB2	-0.748699675207081
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	19/2020	103/9376	0.856214553494184	SLC7A7/SLC8A1/ATP1B3/PRCP/SLC16A10/ATP1B1/KCNE3/COL8A2/SLC3A2/SLC36A1/KCNN4/ATP1A1/SLC36A4/SLC38A2/KCNQ1/COL22A1/COL9A2/COL7A1/COL17A1	-0.768889403170269
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/2020	36/9376	0.773597359735974	AKR1A1/GUSB/CRYL1/SORD/DHDH/FGGY	-0.713180996031485
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	11/2020	63/9376	0.81043532924721	GADD45B/CDKN1A/BAX/APC/GADD45G/BAK1/POLK/DDB2/FZD2/SUFU/PTCH2	-0.791085340600823
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2020	31/9376	0.748642606196103	ALDH2/AKR1A1/GUSB/HSD17B14/ALDH3A2	-0.734553312320589
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	14/2020	79/9376	0.822559217947111	GSTO1/MGST1/MGST2/GSTK1/ALDH3B1/CYP1B1/CBR1/EPHX1/HSD11B1/GSTT1/DHDH/CYP2S1/GSTM4/CBR3	-0.829919627508137
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/2020	37/9376	0.752689322986353	GLUL/IL4I1/GLS/ASRGL1/DDO/ABAT	-0.789830687171285
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/2020	26/9376	0.714089870525514	ACAA1/PLA2G4C/ACOX1/PLA2G4A	-0.764981395907722
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/2020	54/9376	0.773597359735974	SDS/IL4I1/SDSL/LACC1/APIP/BCAT1/GCLC/MAT2B/MAT2A	-0.874307654170126
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	12/2020	70/9376	0.795700141442716	GSTO1/MGST1/MGST2/GSTK1/CYP1B1/CBR1/EPHX1/HSD11B1/GSTT1/SULT1A1/PTGS2/GSTM4	-0.899033809868517
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/2020	86/9376	0.809578632281833	SLC8A1/ITGAV/SNTB1/LMNA/ATP2A2/ITGA6/ITGB5/ACTB/ITGB7/ITGA4/CACNA2D4/SNTB2/ITGB3/ITGA3/ATP2A3	-0.929602988995091
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/2020	33/9376	0.703270327032703	BCAT1/ACO2/OGDH/CS/BCKDHA	-0.894777873455808
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	27/2020	149/9376	0.84109243139079	GNAI2/MGLL/GNB4/PRKACB/ADCY7/MAPK1/ITPR1/GNAQ/ADCY3/PLCB2/MT-ND4L/MT-ND2/GNGT2/NDUFB9/NDUFB5/PTGS2/KCNJ5/PRKACA/ABHD6/GNB1/GNG7/DAGLB/PRKCB/MAPK8/DAGLA/MT-ND3/CACNA1A	-1.02458482487866
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/2020	50/9376	0.742653465346535	ALDH2/SAT1/AOC1/LAP3/SAT2/ALDH3A2/CNDP2/CKM	-0.956084073611066
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/2020	16/9376	0.58019801980198	IL4I1/ALDH3B1	-0.880657447987422
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/2020	46/9376	0.706328024106759	PSMB9/PSMB8/PSMB10/PSME2/PSMD9/PSME4/PSMA6	-1.04626346895601
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	58/2020	308/9376	0.874064549312074	SOD2/GPX1/SLC1A3/TUBA1A/BAX/SDHB/ERN1/ITPR1/SDHD/PPIF/GNAQ/RB1CC1/PLCB2/CREB3L2/MT-ND4L/MT-ND2/AP2S1/BECN1/NDUFB9/NDUFB5/MAP3K5/NRBF2/CASP8/CYCS/PSMD9/CREBBP/ACTR1A/POLR2A/TUBB2A/CREB5/CREB3/KIF5B/HTT/AP2B1/EP300/CREB1/MT-CO1/POLR2J3/BBC3/ATG2A/DCTN4/ACTR1B/UQCRB/PIK3C3/DLG4/ATG14/MAP2K7/TUBA4A/MAPK8/CASP9/PSMA6/MT-ND3/AMBRA1/PIK3R4/ULK2/MT-ATP8/DNAH17/TAF4	-1.17762784469144
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/2020	23/9376	0.605424020662936	FUT4/FKRP/B3GAT2	-0.992794943581686
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	25/2020	143/9376	0.811465761960811	HLA-DPA1/HLA-DPB1/HLA-DMA/FCGR3A/HLA-DRA/HLA-DMB/HLA-DQB1/HLA-DRB1/HLA-DQA1/HLA-DQA2/CD86/FCGR1A/C1QB/C3/HLA-DOA/C1QA/C2/CD40/C1QC/FCGR2A/IL10/CD80/TRIM21/FCGR3B/HLA-DQB2	-1.19049422683458
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	24/2020	138/9376	0.807232027550581	RPS6KA1/PRKACB/YWHAH/ADCY7/CAMK2D/CPEB4/MAPK1/ITPR1/RPS6KA3/ADCY3/RPS6KA2/PPP2R5C/YWHAG/PRKACA/MAD1L1/PPP2R5A/FBXW11/MAP2K1/CPEB2/PPP3CB/PPP3CC/CPEB3/SPDYA/PPP2R5B	-1.19543483305816
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	60/2020	323/9376	0.862213775557122	CD44/ZEB2/MARCKS/ST14/VIM/HMOX1/CDKN1A/NOTCH2/RHOA/MCL1/NFKB1/MMP9/VEGFA/FOXP1/TIMP3/STAT3/ROCK1/GRB2/GLS/DICER1/ATM/DDIT4/CYP1B1/APC/MAPK1/KRAS/PIK3R1/BMPR2/MIR29A/PLAU/SOS2/IRS2/BAK1/CREBBP/BMF/PTGS2/SOS1/PLCG2/BCL2L11/BCL2/IKBKB/CDK6/EP300/SOCS1/NRAS/PIK3CA/MAP2K1/NOTCH1/PRKCB/PIK3CD/MAPK7/RASSF1/SIRT1/SLC45A3/ABCC1/MIR146A/ITGB3/HDAC4/PDGFB/TGFB2	-1.32053909624616
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/2020	31/9376	0.598914084956883	OXA1L/SEC62/TMEM208/SEC63	-1.17211188006632
NA	NA	hsa04081	Hormone signaling	39/2020	219/9376	0.826583480265835	HAMP/GNAI2/CSH1/GNA13/GNB4/RHOA/STAT5A/ITGAV/SLC16A10/PRKACB/CSH2/STAT3/GNA15/ADCY7/GNAQ/PIK3R1/ADCY3/PLCB2/GNGT2/JAK2/THRA/APPL1/IRS2/GNA12/POMC/PRKACA/ADIPOR1/GNB1/SRC/PIK3CA/ACVR1/GNG7/ADIPOR2/PIK3CD/OPRL1/LEPR/ITGB3/SMAD1/CRH	-1.36074384686572
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/2020	19/9376	0.488587806149036	OGDH/BCKDHA	-1.16928405457984
Organismal Systems	Digestive system	hsa04976	Bile secretion	14/2020	90/9376	0.722024202420242	NCEH1/AQP9/ABCC3/ATP1B3/PRKACB/ATP1B1/ADCY7/EPHX1/ADCY3/SCARB1/SLC4A2/ATP1A1/PRKACA/RXRA	-1.388527107559
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	48/2020	268/9376	0.831328505984927	DUSP1/UBE2L6/GNAI2/NFE2L2/TUBA1A/SLC39A11/PRKACB/BAX/SDHB/UBC/ERN1/CAMK2D/ITPR1/SDHD/SLC11A2/BCL2L1/PPIF/LRRK2/PINK1/ATF6/SLC39A3/MT-ND4L/MT-ND2/SNCA/NDUFB9/NDUFB5/MAP3K5/CYCS/PSMD9/TUBB2A/PRKACA/UBA7/SLC39A13/KIF5B/SLC39A8/UBE2J1/MT-CO1/DDIT3/EIF2AK3/UQCRB/MCU/TUBA4A/MAPK8/CASP9/MFN2/PSMA6/MT-ND3/MT-ATP8	-1.46804051162864
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/2020	46/9376	0.605424020662936	HMOX1/FTL/FTH1/GUSB/BLVRA/ALAS1	-1.40575358493855
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/2020	34/9376	0.546068724519511	POLR3GL/POLR2A/CRCP/POLR2J3	-1.3894729485583
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/2020	41/9376	0.566046848587298	SDS/SDSL/ALAS1/PIPOX/GLYCTK	-1.45921093823211
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/2020	54/9376	0.601686835350202	ERCC1/POLK/REV3L/ERCC4/HES1/PALB2/EME2	-1.53818103977906
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	18/2020	117/9376	0.714089870525514	BAZ2B/TFPT/RSF1/BAZ1A/PBRM1/BPTF/EPC1/ACTB/CHD4/SMARCC2/EP400/ARID1B/INO80D/GATAD2B/SRCAP/INO80/INO80B/SMARCD3	-1.63072561734726
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2020	29/9376	0.480163878456811	GNB1/PDE6G/PDE6B	-1.46916236286583
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	29/2020	178/9376	0.756213149404828	JUN/RHOA/PRKACB/MMP7/RAC2/TLE3/CAMK2D/APC/PSEN1/PLCB2/CREBBP/NFATC3/PRKACA/RAC1/EP300/FBXW11/CHD8/PPP3CB/PRKCB/FRAT1/SIRT1/CELSR1/FZD2/PPP3CC/MAPK8/LZTS2/PORCN/NFATC1/FOSL1	-1.72073518088306
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9/2020	68/9376	0.61432731508445	ALDH1A1/DHRS3/DHRS4L2/DHRS9/DHRS4/RDH11/DGAT1/CYP2S1/RETSAT	-1.67257504563337
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/2020	23/9376	0.403616013775291	GLUL/GLS	-1.5005652572966
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/2020	23/9376	0.403616013775291	POLD4/MLH3	-1.5005652572966
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/2020	44/9376	0.527452745274527	CCNH/GTF2I/TAF7/TAF1/TAF4	-1.64635952374967
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/2020	63/9376	0.589407512179789	POLD4/ERCC1/CCNH/POLR2A/DDB2/ERCC4/POLR2J3/ERCC5	-1.71347169694388
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/2020	75/9376	0.618877887788779	SDS/GLUL/SDSL/BCAT1/ACO2/MAT2B/PRPS2/CS/MAT2A/ENO3	-1.73648253174027
Cellular Processes	Cell motility	hsa04814	Motor proteins	31/2020	194/9376	0.741696437685006	MYO9B/MYO1F/TUBA1A/CAPZA2/MYO5A/MYO1E/HOOK3/DYNC1H1/KIFC3/KIF1B/DYNLT3/KIF13B/ACTB/DYNC1LI1/KIF13A/ACTR1A/TUBB2A/CAPZA1/KIF5B/MYO1G/CAPZB/KIF16B/DCTN4/ACTR1B/KIF1C/MYL6/KIF3B/MYO9A/TUBA4A/MYL5/DNAH17	-1.90503552613097
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/2020	39/9376	0.476059913683676	MTHFR/MAT2B/MTHFD2/MAT2A	-1.7181090049338
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	10/2020	78/9376	0.595074892104595	BTG1/BTG2/TOB1/PABPC1/XRN1/CNOT6L/CNOT4/ZCCHC7/PATL1/ENO3	-1.88177502234162
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	24/2020	158/9376	0.705050758240381	GADD45B/CDKN1A/YWHAH/NIPBL/ATM/ATRX/CCNH/TGFB1/GADD45G/PPP2R5C/CREBBP/YWHAG/SMAD2/MAD1L1/RBL2/CDK6/PPP2R5A/EP300/ESCO1/MAU2/ZBTB17/PPP2R5B/CDKN2B/TGFB2	-1.95928646472241
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8/2020	66/9376	0.562616261626163	HSD17B11/DHRS9/SRD5A3/CYP1B1/HSD11B1/HSD17B12/SRD5A1/AKR1C3	-1.86853063305569
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/2020	17/9376	0.273034362259755	GLUL	-1.57204177535429
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/2020	26/9376	0.357044935262757	HHEX/HES1	-1.72029114125013
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/2020	73/9376	0.572250101722501	GSTO1/MGST1/MGST2/GSTK1/ALDH3B1/GSTT1/GSTM4/FMO4/FMO5	-1.92256174790219
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/2020	41/9376	0.452837478869838	POLD4/ATM/NBN/PALB2	-1.83988878344258
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/2020	87/9376	0.586866962558325	SLC8A1/ATP1B3/ATP1B1/ATP2A2/ATP1A1/CACNA2D4/MT-CO1/SLC9A7/SLC9A6/UQCRB/ATP2A3	-2.02864256471966
Human Diseases	Substance dependence	hsa05034	Alcoholism	29/2020	191/9376	0.704743144471515	GNAI2/GNB4/FOSB/PRKACB/SLC29A3/GRB2/MAPK1/KRAS/CREB3L2/GNGT2/SOS2/CREB5/SOS1/CREB3/PRKACA/GNB1/ATF6B/CREB1/HDAC10/NRAS/MAP2K1/HDAC7/GNG7/ARAF/ADORA2B/CAMKK1/GRIN3A/HDAC4/CRH	-2.16031736292075
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/2020	37/9376	0.376344661493176	IL4I1/ALDH3B1/FAH	-1.9917543816505
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2020	30/9376	0.309438943894389	PLA2G4C/PLA2G4A	-1.98513608794682
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/2020	23/9376	0.201808006887645	ACAT1	-2.00833557101152
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	13/2020	108/9376	0.558709204253759	NUP214/RANBP2/TMEM33/KPNA3/KPNA4/SUMO3/DDX19B/POM121/IPO13/KPNA1/DDX39B/POM121C/KPNA5	-2.41704199999412
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/2020	103/9376	0.54076708641738	PABPC1/PPP2R3C/PPP2R5C/SMG1/PPP2R5A/CPSF2/DDX19B/PPP2R2D/DDX39B/GSPT2/PAPOLG/PPP2R5B	-2.45573755495764
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/2020	36/9376	0.257865786578658	POLD4/RNASEH2B	-2.33776433393022
Organismal Systems	Sensory system	hsa04742	Taste transduction	8/2020	86/9376	0.431775270550311	PRKACB/PLCB2/PRKACA/PKD2L1/SCN9A/PDE1B/GABBR1/CACNA1A	-2.7739712892891
NA	NA	hsa04082	Neuroactive ligand signaling	26/2020	199/9376	0.606438131250311	GNAI2/GNB4/SLC1A3/P2RX4/P2RY11/PRKACB/ADCY7/GNAQ/ADCY3/OGFR/PLCB2/GNGT2/SLC17A9/POMC/AGRP/PRKACA/GNB1/GNG7/PRKCB/SLC6A12/TAC3/HRH2/ADORA2B/OPRL1/GRIN3A/GABBR1	-2.94055731712588
NA	NA	hsa04382	Cornified envelope formation	29/2020	217/9376	0.620303873705343	ST14/S100A4/S100A10/S100A6/S100A8/DST/UGCG/PLEC/SLC27A1/S100A11/PADI2/ITGA6/PPP2R3C/PPP2R5C/ELOVL1/ABHD5/FURIN/CLDN23/PPP2R5A/SPTLC2/LAMB3/SLC27A4/PPP2R2D/TCHH/S100A2/COL7A1/PPP2R5B/COL17A1/CLDN1	-2.96539442330277
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/2020	41/9376	0.226418739434919	GRIN3A/CACNA1A	-2.60124447386352
NA	NA	hsa04519	Cadherin signaling	60/2020	404/9376	0.689344181942947	LHFPL2/VIM/NFKBIA/MRAS/RRAS/NCKAP1L/TAOK3/ARPC1B/RHOA/MYO1F/ARPC4/NFKB1/ACTR3/ARPC3/ADAM10/APH1B/MOB1A/YWHAH/APH1A/ACTR2/EVL/ROCK1/TMC6/MYO1E/PSENEN/RAC2/VAV1/NCSTN/APC/TAOK1/MAPK1/PSEN1/KRAS/ARPC2/CYFIP1/PSEN2/VASP/SHOC2/IKBKG/CREBBP/ACTB/YWHAG/PTK2B/TMC8/MAP2K3/IKBKB/ARHGAP35/MYO1G/RAC1/EP300/MOB1B/NRAS/MAP2K1/NF2/CHUK/CELSR1/FZD2/LATS2/MAPK8/TAOK2	-3.34476803678747
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	36/2020	370/9376	0.451613593791812	C5AR1/FPR3/TSPO/CSH1/PTGER4/C3AR1/C3/P2RX4/PTAFR/P2RY11/NR3C1/P2RX7/CSH2/FPR1/GPR35/S1PR4/OGFR/THRA/UTS2/PTGER2/POMC/NMB/LPAR1/TAC3/HRH2/P2RY8/LPAR2/ADORA2B/OPRL1/LEPR/GRIN3A/CHRNE/GABBR1/FPR2/EDN1/CRH	-5.63977832379607
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/2020	243/9376	0.210112863138166	HSPA1B/HSPA1A/DDX5/HSPA6/SLU7/BCAS2/CDC40/U2AF1L4/DHX8/PCBP1/DDX39B	-6.53735263483405
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/2020	183/9376	0.101455391440783	NOP10/XRN1/UTP14C/SNORD3B-2	-6.43245890218836
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	12/2020	449/9376	0.124051246995524	RGS2/SLC8A1/ARRB2/PRKACB/CAMK2D/ADCY3/ARRB1/PRKACA/GNB1/GNG7/SLC24A4/PDE1B	-9.96757620052753