ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 182/3944 489/18639 0.372188139059305 1.75892868253711 1.30984770260055e-16 1.1154079367686e-13 GO:0060589 nucleoside-triphosphatase regulator activity 182/3944 490/18639 0.371428571428571 1.75533903216459 1.65613650596675e-16 1.1154079367686e-13 GO:0106310 protein serine kinase activity 135/3944 361/18639 0.373961218836565 1.76730810291449 7.77723490296914e-13 3.49197847143314e-10 GO:0004674 protein serine/threonine kinase activity 154/3944 433/18639 0.355658198614319 1.68080962575362 2.11219826191731e-12 7.11282764700655e-10 GO:0005096 GTPase activator activity 105/3944 271/18639 0.387453874538745 1.83107321691878 2.39666074942132e-11 6.45660405894105e-09 GO:0035091 phosphatidylinositol binding 106/3944 284/18639 0.373239436619718 1.7638970231123 2.53021197218681e-10 5.6803258775594e-08 GO:0005085 guanyl-nucleotide exchange factor activity 89/3944 230/18639 0.38695652173913 1.82872277096746 8.39326359510206e-10 1.61510372322892e-07 GO:0031267 small GTPase binding 104/3944 283/18639 0.367491166077739 1.73673119790136 1.02080059622934e-09 1.71877300390115e-07 GO:0051020 GTPase binding 112/3944 315/18639 0.355555555555556 1.68032454361055 2.17034979764214e-09 3.24829019713774e-07 GO:0140375 immune receptor activity 65/3944 156/18639 0.416666666666667 1.96913032454361 5.17481089151858e-09 6.97047027087552e-07 GO:0140996 histone H3 kinase activity 122/3944 357/18639 0.341736694677871 1.61501781239879 6.51931398133489e-09 7.98319630259827e-07 GO:0035173 histone kinase activity 122/3944 360/18639 0.338888888888889 1.6015593306288 1.13552218971075e-08 1.15731965772277e-06 GO:0141003 histone H2AX kinase activity 120/3944 354/18639 0.338983050847458 1.60200433183209 1.46716805274664e-08 1.15731965772277e-06 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 89/3944 243/18639 0.366255144032922 1.73088986552475 1.92649963250961e-08 1.15731965772277e-06 GO:0035402 histone H3T11 kinase activity 90/3944 247/18639 0.364372469635628 1.72199251053206 2.13412705713296e-08 1.15731965772277e-06 GO:0035403 histone H3T6 kinase activity 90/3944 247/18639 0.364372469635628 1.72199251053206 2.13412705713296e-08 1.15731965772277e-06 GO:0005543 phospholipid binding 157/3944 497/18639 0.3158953722334 1.49289397643467 2.43814578023563e-08 1.15731965772277e-06 GO:0004679 AMP-activated protein kinase activity 90/3944 248/18639 0.362903225806452 1.71504899234443 2.66164264644992e-08 1.15731965772277e-06 GO:0004676 3-phosphoinositide-dependent protein kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0004711 ribosomal protein S6 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0035175 histone H3S10 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0035979 histone H2AXS139 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0044022 histone H3S28 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0044023 histone H4S1 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0044024 histone H2AS1 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0044025 histone H2BS14 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0072354 histone H3T3 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0072371 histone H2AS121 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0072518 Rho-dependent protein serine/threonine kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0140823 histone H2BS36 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0140855 histone H3S57 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0140995 histone H2A kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0140997 histone H4 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0140998 histone H2B kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:1990244 histone H2AT120 kinase activity 89/3944 245/18639 0.363265306122449 1.7167601523368 3.00714090722324e-08 1.15731965772277e-06 GO:0004677 DNA-dependent protein kinase activity 89/3944 246/18639 0.361788617886179 1.70978145253055 3.74403116353805e-08 1.36302972359074e-06 GO:0140857 histone H3T45 kinase activity 89/3944 246/18639 0.361788617886179 1.70978145253055 3.74403116353805e-08 1.36302972359074e-06 GO:0044389 ubiquitin-like protein ligase binding 109/3944 322/18639 0.338509316770186 1.59976550590251 7.20227678091616e-08 2.55301758523528e-06 GO:0140297 DNA-binding transcription factor binding 151/3944 488/18639 0.309426229508197 1.46232137216107 1.8995624797854e-07 6.56079656479727e-06 GO:0019207 kinase regulator activity 98/3944 287/18639 0.341463414634146 1.61372631474793 2.03152264346209e-07 6.8411525018586e-06 GO:0004197 cysteine-type endopeptidase activity 40/3944 88/18639 0.454545454545455 2.14814217222939 2.85564769997078e-07 9.38184744356252e-06 GO:0019787 ubiquitin-like protein transferase activity 147/3944 479/18639 0.306889352818372 1.45033231419412 4.7219454387213e-07 1.51439535856133e-05 GO:0000149 SNARE binding 45/3944 106/18639 0.424528301886792 2.00628372689349 5.98148463309239e-07 1.87373483738964e-05 GO:0031625 ubiquitin protein ligase binding 99/3944 302/18639 0.327814569536424 1.54922306328332 1.48637085143914e-06 4.55032167474663e-05 GO:0016755 aminoacyltransferase activity 149/3944 496/18639 0.300403225806452 1.41967944366289 1.56234347067116e-06 4.67661478887567e-05 GO:0004842 ubiquitin-protein transferase activity 137/3944 449/18639 0.305122494432071 1.44198229556779 1.62492271187997e-06 4.75819759326592e-05 GO:0023023 MHC protein complex binding 21/3944 37/18639 0.567567567567568 2.6822748204594 2.36466660894111e-06 6.7770338771142e-05 GO:0023026 MHC class II protein complex binding 17/3944 27/18639 0.62962962962963 2.97557471264368 3.07075374400473e-06 8.61730269411326e-05 GO:0001217 DNA-binding transcription repressor activity 91/3944 278/18639 0.327338129496403 1.5469714492098 4.14089178389058e-06 0.000113832270059196 GO:0019902 phosphatase binding 67/3944 190/18639 0.352631578947368 1.6665060851927 4.77233507344233e-06 0.000128566706878536 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 88/3944 268/18639 0.328358208955224 1.55179225575974 5.14745087877132e-06 0.000135953261445195 GO:0003779 actin binding 132/3944 443/18639 0.297968397291196 1.40817265646821 9.46924919047718e-06 0.00023964786381559 GO:0061659 ubiquitin-like protein ligase activity 114/3944 372/18639 0.306451612903226 1.4482635935353 9.47859498837872e-06 0.00023964786381559 GO:0046332 SMAD binding 34/3944 79/18639 0.430379746835443 2.03393714535137 9.60726402824192e-06 0.00023964786381559 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 108/3944 349/18639 0.30945558739255 1.4624601149619 1.00354147613219e-05 0.000245776430609102 GO:0042625 ATPase-coupled ion transmembrane transporter activity 15/3944 24/18639 0.625 2.95369548681542 1.35655878864717e-05 0.00031504908419099 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 15/3944 24/18639 0.625 2.95369548681542 1.35655878864717e-05 0.00031504908419099 GO:0046961 proton-transporting ATPase activity, rotational mechanism 15/3944 24/18639 0.625 2.95369548681542 1.35655878864717e-05 0.00031504908419099 GO:0005126 cytokine receptor binding 88/3944 275/18639 0.32 1.51229208924949 1.59411728484216e-05 0.000363945081810574 GO:0019887 protein kinase regulator activity 82/3944 255/18639 0.32156862745098 1.51970528576542 2.50503064974726e-05 0.000556627913679058 GO:0019903 protein phosphatase binding 52/3944 144/18639 0.361111111111111 1.70657961460446 2.52073516959336e-05 0.000556627913679058 GO:0035325 Toll-like receptor binding 10/3944 13/18639 0.769230769230769 3.63531752223436 2.69446155553689e-05 0.000585393502469063 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 25/3944 54/18639 0.462962962962963 2.18792258282623 3.21091213600594e-05 0.00068652359479365 GO:0051019 mitogen-activated protein kinase binding 16/3944 28/18639 0.571428571428571 2.70052158794552 3.41981295073946e-05 0.000719763756975945 GO:0008234 cysteine-type peptidase activity 63/3944 187/18639 0.336898395721925 1.59215243353473 4.51537448858768e-05 0.000935724528635016 GO:0061630 ubiquitin protein ligase activity 106/3944 353/18639 0.30028328611898 1.41911261916117 4.86816169236584e-05 0.000993547545396484 GO:0042626 ATPase-coupled transmembrane transporter activity 38/3944 98/18639 0.387755102040816 1.83249679182018 5.1612064686752e-05 0.00103763359900082 GO:0019209 kinase activator activity 52/3944 148/18639 0.351351351351351 1.66045584123677 5.86379583819418e-05 0.00116154896971288 GO:1901981 phosphatidylinositol phosphate binding 62/3944 185/18639 0.335135135135135 1.58381941779508 6.15052491701534e-05 0.00120068942945212 GO:0032182 ubiquitin-like protein binding 44/3944 120/18639 0.366666666666667 1.73283468559838 6.75519394132264e-05 0.00129989231985166 GO:0043130 ubiquitin binding 38/3944 100/18639 0.38 1.79584685598377 8.60334931638321e-05 0.00163221289143214 GO:0001540 amyloid-beta binding 33/3944 83/18639 0.397590361445783 1.87897736992595 8.85906974797282e-05 0.00165738429868325 GO:0046915 transition metal ion transmembrane transporter activity 21/3944 45/18639 0.466666666666667 2.20542596348884 0.000117638283423263 0.00213218753018021 GO:0032395 MHC class II receptor activity 8/3944 10/18639 0.8 3.78073022312373 0.000118718682081304 0.00213218753018021 GO:0043422 protein kinase B binding 8/3944 10/18639 0.8 3.78073022312373 0.000118718682081304 0.00213218753018021 GO:0019905 syntaxin binding 26/3944 61/18639 0.426229508196721 2.01432347953314 0.000126546720834747 0.00224287411795268 GO:0032934 sterol binding 28/3944 68/18639 0.411764705882353 1.94596408543133 0.000145695078684398 0.00254871780503745 GO:0019003 GDP binding 30/3944 75/18639 0.4 1.89036511156187 0.000160186129628334 0.00276629123858161 GO:0042277 peptide binding 77/3944 249/18639 0.309236947791165 1.46142684327574 0.000180949094600895 0.00308529658768869 GO:0002020 protease binding 47/3944 136/18639 0.345588235294118 1.63321985741558 0.0002025942242462 0.0034111802507454 GO:0019955 cytokine binding 49/3944 144/18639 0.340277777777778 1.60812309837728 0.00022940017652215 0.00381483997253501 GO:0042578 phosphoric ester hydrolase activity 105/3944 363/18639 0.289256198347107 1.36699956414598 0.0002579333205012 0.00423702661847704 GO:0016798 hydrolase activity, acting on glycosyl bonds 45/3944 130/18639 0.346153846153846 1.63589288500546 0.000262288642339807 0.00425666025580386 GO:0001727 lipid kinase activity 19/3944 41/18639 0.463414634146341 2.19005714144363 0.000275729927438949 0.00442152633643171 GO:0120015 sterol transfer activity 16/3944 32/18639 0.5 2.36295638945233 0.000282420487704894 0.00447553408162932 GO:0003925 G protein activity 23/3944 54/18639 0.425925925925926 2.01288877620014 0.00030901629959812 0.00484005762277521 GO:0004715 non-membrane spanning protein tyrosine kinase activity 20/3944 45/18639 0.444444444444444 2.10040567951318 0.000382647026374366 0.00592443154627898 GO:0022804 active transmembrane transporter activity 127/3944 457/18639 0.277899343544858 1.31332805890786 0.000396769584160316 0.00605891806077488 GO:0015923 mannosidase activity 10/3944 16/18639 0.625 2.95369548681542 0.000400329404164042 0.00605891806077488 GO:0003924 GTPase activity 96/3944 331/18639 0.290030211480363 1.37065748270347 0.00041809394687462 0.00625747273822348 GO:0003712 transcription coregulator activity 136/3944 495/18639 0.274747474747475 1.29843260188088 0.000425918586810058 0.00630453116959503 GO:0016922 nuclear receptor binding 46/3944 137/18639 0.335766423357664 1.5868028308731 0.000490313704028578 0.00717883216659234 GO:0017124 SH3 domain binding 40/3944 115/18639 0.347826086956522 1.64379574918423 0.000500949204300978 0.00725568363648836 GO:0005525 GTP binding 107/3944 378/18639 0.283068783068783 1.33775837921375 0.000539557120110822 0.00773173873180082 GO:0033691 sialic acid binding 12/3944 22/18639 0.545454545454545 2.57777060667527 0.00059839506868694 0.00848461218443483 GO:0120020 cholesterol transfer activity 13/3944 25/18639 0.52 2.45747464503043 0.000650769593936116 0.00913111086491612 GO:0016411 acylglycerol O-acyltransferase activity 15/3944 31/18639 0.483870967741935 2.28673198979258 0.000681704635420413 0.00946655818465254 GO:0032813 tumor necrosis factor receptor superfamily binding 21/3944 50/18639 0.42 1.98488336713996 0.000697213061544729 0.00952062294244243 GO:0030295 protein kinase activator activity 46/3944 139/18639 0.330935251798561 1.56397113546485 0.000699733980179511 0.00952062294244243 GO:0016504 peptidase activator activity 23/3944 57/18639 0.403508771929825 1.90694726166329 0.00077871081816014 0.0104892347206171 GO:0008429 phosphatidylethanolamine binding 10/3944 17/18639 0.588235294117647 2.77994869347333 0.000787932970059378 0.0105083733729701 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 69/3944 229/18639 0.301310043668122 1.4239649857835 0.000841482110906309 0.0110477231292882 GO:0004875 complement receptor activity 8/3944 12/18639 0.666666666666667 3.15060851926978 0.000864408812681232 0.0110477231292882 GO:0035014 phosphatidylinositol 3-kinase regulator activity 8/3944 12/18639 0.666666666666667 3.15060851926978 0.000864408812681232 0.0110477231292882 GO:0070008 serine-type exopeptidase activity 8/3944 12/18639 0.666666666666667 3.15060851926978 0.000864408812681232 0.0110477231292882 GO:0035591 signaling adaptor activity 43/3944 129/18639 0.333333333333333 1.57530425963489 0.000869382814925429 0.0110477231292882 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 18/3944 41/18639 0.439024390243902 2.07479097610449 0.000884983347391215 0.0110684207138442 GO:0004896 cytokine receptor activity 34/3944 96/18639 0.354166666666667 1.67376077586207 0.000887445758793741 0.0110684207138442 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 12/3944 23/18639 0.521739130434783 2.46569362377635 0.00101129076435315 0.0122721500863396 GO:0042171 lysophosphatidic acid acyltransferase activity 12/3944 23/18639 0.521739130434783 2.46569362377635 0.00101129076435315 0.0122721500863396 GO:0071617 lysophospholipid acyltransferase activity 12/3944 23/18639 0.521739130434783 2.46569362377635 0.00101129076435315 0.0122721500863396 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 43/3944 130/18639 0.330769230769231 1.56318653456077 0.00103711196223165 0.0123081109456297 GO:0038187 pattern recognition receptor activity 20/3944 48/18639 0.416666666666667 1.96913032454361 0.00104594997601453 0.0123081109456297 GO:0050681 nuclear androgen receptor binding 13/3944 26/18639 0.5 2.36295638945233 0.00105080382980506 0.0123081109456297 GO:0052742 phosphatidylinositol kinase activity 13/3944 26/18639 0.5 2.36295638945233 0.00105080382980506 0.0123081109456297 GO:0120013 lipid transfer activity 25/3944 65/18639 0.384615384615385 1.81765876111718 0.00107964685220631 0.0125369337062233 GO:0042605 peptide antigen binding 19/3944 45/18639 0.422222222222222 1.99538539553753 0.00114456339268357 0.0131625618758837 GO:0140313 molecular sequestering activity 22/3944 55/18639 0.4 1.89036511156187 0.00115306778125781 0.0131625618758837 GO:0004559 alpha-mannosidase activity 9/3944 15/18639 0.6 2.8355476673428 0.00120287687007386 0.013502292866579 GO:0047372 monoacylglycerol lipase activity 9/3944 15/18639 0.6 2.8355476673428 0.00120287687007386 0.013502292866579 GO:0070513 death domain binding 7/3944 10/18639 0.7 3.30813894523327 0.00123216327848544 0.01368524832885 GO:0003713 transcription coactivator activity 75/3944 256/18639 0.29296875 1.38454475944473 0.00123949539429821 0.01368524832885 GO:0019001 guanyl nucleotide binding 110/3944 400/18639 0.275 1.29962601419878 0.00138294629490231 0.0150228117680114 GO:0032561 guanyl ribonucleotide binding 110/3944 400/18639 0.275 1.29962601419878 0.00138294629490231 0.0150228117680114 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 32/3944 91/18639 0.351648351648352 1.66185943873571 0.00141811032837175 0.0152815568985339 GO:0032393 MHC class I receptor activity 10/3944 18/18639 0.555555555555556 2.62550709939148 0.00143758835072339 0.015294275537963 GO:0005484 SNAP receptor activity 16/3944 36/18639 0.444444444444444 2.10040567951318 0.0014419992526513 0.015294275537963 GO:0140311 protein sequestering activity 15/3944 33/18639 0.454545454545455 2.14814217222939 0.00152808863781239 0.0160807452744789 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 11/3944 21/18639 0.523809523809524 2.4754781222834 0.00157562354138181 0.0164524411646612 GO:0001968 fibronectin binding 14/3944 30/18639 0.466666666666667 2.20542596348884 0.00159648909992304 0.0165420832122795 GO:0004721 phosphoprotein phosphatase activity 54/3944 175/18639 0.308571428571429 1.45828165749058 0.00162676984381647 0.016689750592119 GO:0015295 solute:proton symporter activity 12/3944 24/18639 0.5 2.36295638945233 0.0016355212161542 0.016689750592119 GO:0001618 virus receptor activity 29/3944 81/18639 0.358024691358025 1.69199346405229 0.00169406190239266 0.0170291147949471 GO:0015101 organic cation transmembrane transporter activity 29/3944 81/18639 0.358024691358025 1.69199346405229 0.00169406190239266 0.0170291147949471 GO:0004712 protein serine/threonine/tyrosine kinase activity 18/3944 43/18639 0.418604651162791 1.97828907023916 0.00172322279258143 0.0171939340859792 GO:0032396 inhibitory MHC class I receptor activity 8/3944 13/18639 0.615384615384615 2.90825401778749 0.00183048539328758 0.0179975461661195 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 8/3944 13/18639 0.615384615384615 2.90825401778749 0.00183048539328758 0.0179975461661195 GO:0030246 carbohydrate binding 80/3944 280/18639 0.285714285714286 1.35026079397276 0.00190763188909157 0.0186201460478721 GO:0140272 exogenous protein binding 29/3944 82/18639 0.353658536585366 1.6713593974175 0.00209915700577363 0.0203421905523531 GO:0016791 phosphatase activity 78/3944 273/18639 0.285714285714286 1.35026079397276 0.00215421227413412 0.0207265995232761 GO:0003725 double-stranded RNA binding 27/3944 75/18639 0.36 1.70132860040568 0.00219452792028293 0.0209647454512135 GO:0015485 cholesterol binding 21/3944 54/18639 0.388888888888889 1.83785496957404 0.00224040458500831 0.0212522885634239 GO:0140767 enzyme-substrate adaptor activity 44/3944 139/18639 0.316546762589928 1.49597239044464 0.00243479263743307 0.0229347250533031 GO:0005319 lipid transporter activity 54/3944 178/18639 0.303370786516854 1.43370387674636 0.00246049512362364 0.0230158814688961 GO:0008526 phosphatidylinositol transfer activity 7/3944 11/18639 0.636363636363636 3.00739904112115 0.00276889493440614 0.025372118888742 GO:0019864 IgG binding 7/3944 11/18639 0.636363636363636 3.00739904112115 0.00276889493440614 0.025372118888742 GO:0047676 arachidonate-CoA ligase activity 7/3944 11/18639 0.636363636363636 3.00739904112115 0.00276889493440614 0.025372118888742 GO:0033218 amide binding 71/3944 247/18639 0.287449392712551 1.35846075830863 0.00280005648290369 0.0254842978545356 GO:0008374 O-acyltransferase activity 21/3944 55/18639 0.381818181818182 1.80443942467269 0.00291199496379539 0.0263252162163248 GO:0005545 1-phosphatidylinositol binding 8/3944 14/18639 0.571428571428571 2.70052158794552 0.00348132870012027 0.03126233172708 GO:0048487 beta-tubulin binding 17/3944 42/18639 0.404761904761905 1.91286945812808 0.00350797379425112 0.0312929847738825 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 13/3944 29/18639 0.448275862068966 2.11851262502623 0.00361739249514913 0.0316404395517264 GO:0051861 glycolipid binding 13/3944 29/18639 0.448275862068966 2.11851262502623 0.00361739249514913 0.0316404395517264 GO:0097472 cyclin-dependent protein kinase activity 13/3944 29/18639 0.448275862068966 2.11851262502623 0.00361739249514913 0.0316404395517264 GO:0008157 protein phosphatase 1 binding 12/3944 26/18639 0.461538461538462 2.18119051334061 0.00382485318539877 0.0332392080047235 GO:0046965 nuclear retinoid X receptor binding 9/3944 17/18639 0.529411764705882 2.501953824126 0.00386236308409374 0.0333500197068863 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 11/3944 23/18639 0.478260869565217 2.26021915512832 0.00396594982632324 0.0340263338602383 GO:0016757 glycosyltransferase activity 75/3944 267/18639 0.280898876404494 1.32750358957996 0.00414835261711947 0.035366018830759 GO:0005496 steroid binding 35/3944 108/18639 0.324074074074074 1.53154580797836 0.0042063696076239 0.035635093468361 GO:1901505 carbohydrate derivative transmembrane transporter activity 20/3944 53/18639 0.377358490566038 1.78336331279421 0.0042431382111823 0.035721919815391 GO:0019239 deaminase activity 14/3944 33/18639 0.424242424242424 2.00493269408077 0.00473286322159899 0.0393528812314435 GO:0019956 chemokine binding 14/3944 33/18639 0.424242424242424 2.00493269408077 0.00473286322159899 0.0393528812314435 GO:0019210 kinase inhibitor activity 30/3944 90/18639 0.333333333333333 1.57530425963489 0.00488661490047229 0.0403820262020624 GO:0004713 protein tyrosine kinase activity 43/3944 140/18639 0.307142857142857 1.45153035352072 0.00500367094771378 0.0409897066642013 GO:0030145 manganese ion binding 24/3944 68/18639 0.352941176470588 1.667969216084 0.00502101083859926 0.0409897066642013 GO:0031624 ubiquitin conjugating enzyme binding 13/3944 30/18639 0.433333333333333 2.04789553752535 0.00516278920914554 0.0416423776330481 GO:0032452 histone demethylase activity 13/3944 30/18639 0.433333333333333 2.04789553752535 0.00516278920914554 0.0416423776330481 GO:0004177 aminopeptidase activity 16/3944 40/18639 0.4 1.89036511156187 0.00523607138594358 0.0419820723622976 GO:0004725 protein tyrosine phosphatase activity 32/3944 98/18639 0.326530612244898 1.54315519311173 0.00530806517847657 0.0423074780793369 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 7/3944 12/18639 0.583333333333333 2.75678245436105 0.00543517550482102 0.0423189676589244 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 7/3944 12/18639 0.583333333333333 2.75678245436105 0.00543517550482102 0.0423189676589244 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 7/3944 12/18639 0.583333333333333 2.75678245436105 0.00543517550482102 0.0423189676589244 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 7/3944 12/18639 0.583333333333333 2.75678245436105 0.00543517550482102 0.0423189676589244 GO:0008238 exopeptidase activity 33/3944 102/18639 0.323529411764706 1.52897178141033 0.00549459713581736 0.0425357605858964 GO:0038024 cargo receptor activity 23/3944 65/18639 0.353846153846154 1.6722460602278 0.00573870878720618 0.044171661350667 GO:0000287 magnesium ion binding 65/3944 230/18639 0.282608695652174 1.33558404621219 0.00623288055969049 0.0477027847380857 GO:0030228 lipoprotein particle receptor activity 9/3944 18/18639 0.5 2.36295638945233 0.00628713781746411 0.0478461844074811 GO:0004860 protein kinase inhibitor activity 28/3944 84/18639 0.333333333333333 1.57530425963489 0.00640331503183926 0.0484565468982443 GO:0052866 phosphatidylinositol phosphate phosphatase activity 14/3944 34/18639 0.411764705882353 1.94596408543133 0.00650236178411412 0.048931180576546 GO:0015399 primary active transmembrane transporter activity 49/3944 166/18639 0.295180722891566 1.39499835039957 0.00675735763070438 0.0505675596031044 GO:0016407 acetyltransferase activity 31/3944 96/18639 0.322916666666667 1.5260760015213 0.00718679158403418 0.0529552286118695 GO:0005164 tumor necrosis factor receptor binding 13/3944 31/18639 0.419354838709677 1.98183439115357 0.00719436290718049 0.0529552286118695 GO:0140457 protein demethylase activity 13/3944 31/18639 0.419354838709677 1.98183439115357 0.00719436290718049 0.0529552286118695 GO:0031072 heat shock protein binding 40/3944 131/18639 0.305343511450382 1.44302680271898 0.00736379944601612 0.0539078144227376 GO:0070851 growth factor receptor binding 42/3944 139/18639 0.302158273381295 1.42797364542443 0.00749436836641964 0.0545671037273905 GO:0141052 histone H3 demethylase activity 12/3944 28/18639 0.428571428571429 2.02539119095914 0.0079050863809232 0.0569990014462496 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 29/3944 89/18639 0.325842696629214 1.53990416391276 0.0079553172025946 0.0569990014462496 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 29/3944 89/18639 0.325842696629214 1.53990416391276 0.0079553172025946 0.0569990014462496 GO:0051213 dioxygenase activity 30/3944 93/18639 0.32258064516129 1.52448799319505 0.00822380399813998 0.0586109205581722 GO:0008140 cAMP response element binding protein binding 6/3944 10/18639 0.6 2.8355476673428 0.00850178593418549 0.0588060922354384 GO:0008239 dipeptidyl-peptidase activity 6/3944 10/18639 0.6 2.8355476673428 0.00850178593418549 0.0588060922354384 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 6/3944 10/18639 0.6 2.8355476673428 0.00850178593418549 0.0588060922354384 GO:0015924 mannosyl-oligosaccharide mannosidase activity 6/3944 10/18639 0.6 2.8355476673428 0.00850178593418549 0.0588060922354384 GO:1905394 retromer complex binding 6/3944 10/18639 0.6 2.8355476673428 0.00850178593418549 0.0588060922354384 GO:0140789 histone phosphatase activity 41/3944 136/18639 0.301470588235294 1.42472370540508 0.00851313139265812 0.0588060922354384 GO:0050321 tau-protein kinase activity 10/3944 22/18639 0.454545454545455 2.14814217222939 0.00924010213369904 0.0628152563372674 GO:0061133 endopeptidase activator activity 10/3944 22/18639 0.454545454545455 2.14814217222939 0.00924010213369904 0.0628152563372674 GO:0140035 ubiquitin-like protein reader activity 10/3944 22/18639 0.454545454545455 2.14814217222939 0.00924010213369904 0.0628152563372674 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 21/3944 60/18639 0.35 1.65406947261663 0.00928726123974828 0.0628152563372674 GO:1990782 protein tyrosine kinase binding 36/3944 117/18639 0.307692307692308 1.45412700889374 0.00932668987932701 0.0628152563372674 GO:0140793 histone H2AXY142 phosphatase activity 29/3944 90/18639 0.322222222222222 1.52279411764706 0.00941420846098063 0.0630892477459747 GO:0017154 semaphorin receptor activity 7/3944 13/18639 0.538461538461538 2.54472226556405 0.00964064730161004 0.0642868906696472 GO:0015245 fatty acid transmembrane transporter activity 9/3944 19/18639 0.473684210526316 2.23859026369168 0.00972940381401094 0.0643440120404374 GO:0000062 fatty-acyl-CoA binding 8/3944 16/18639 0.5 2.36295638945233 0.00993582368553154 0.0643440120404374 GO:0005149 interleukin-1 receptor binding 8/3944 16/18639 0.5 2.36295638945233 0.00993582368553154 0.0643440120404374 GO:0005324 long-chain fatty acid transmembrane transporter activity 8/3944 16/18639 0.5 2.36295638945233 0.00993582368553154 0.0643440120404374 GO:0034450 ubiquitin-ubiquitin ligase activity 8/3944 16/18639 0.5 2.36295638945233 0.00993582368553154 0.0643440120404374 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 8/3944 16/18639 0.5 2.36295638945233 0.00993582368553154 0.0643440120404374 GO:0016298 lipase activity 39/3944 130/18639 0.3 1.4177738336714 0.0109857732230393 0.070803045604947 GO:0015605 organophosphate ester transmembrane transporter activity 18/3944 50/18639 0.36 1.70132860040568 0.0112424584562221 0.0721123406691963 GO:0008375 acetylglucosaminyltransferase activity 16/3944 43/18639 0.372093023255814 1.75847917354592 0.0116153651666449 0.0738014003748619 GO:0048156 tau protein binding 16/3944 43/18639 0.372093023255814 1.75847917354592 0.0116153651666449 0.0738014003748619 GO:0070412 R-SMAD binding 11/3944 26/18639 0.423076923076923 1.9994246372289 0.0121087725526952 0.0763346061410565 GO:0001221 transcription coregulator binding 35/3944 115/18639 0.304347826086957 1.4383212805362 0.0122407386239556 0.0763346061410565 GO:0035401 histone H3Y41 kinase activity 35/3944 115/18639 0.304347826086957 1.4383212805362 0.0122407386239556 0.0763346061410565 GO:0140801 histone H2AXY142 kinase activity 35/3944 115/18639 0.304347826086957 1.4383212805362 0.0122407386239556 0.0763346061410565 GO:0015291 secondary active transmembrane transporter activity 77/3944 287/18639 0.268292682926829 1.26792781873052 0.0123525471071124 0.0766768707524442 GO:0071889 14-3-3 protein binding 13/3944 33/18639 0.393939393939394 1.86172321593214 0.0131081596485022 0.0809939956262959 GO:0051015 actin filament binding 58/3944 209/18639 0.277511961722488 1.31149732620321 0.0137524870326568 0.0845872147625055 GO:0015179 L-amino acid transmembrane transporter activity 21/3944 62/18639 0.338709677419355 1.60071239285481 0.0138762806835396 0.0849606821851264 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 8/3944 17/18639 0.470588235294118 2.22395895477867 0.015334455331254 0.0900806550669181 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 8/3944 17/18639 0.470588235294118 2.22395895477867 0.015334455331254 0.0900806550669181 GO:0015278 intracellularly gated calcium channel activity 8/3944 17/18639 0.470588235294118 2.22395895477867 0.015334455331254 0.0900806550669181 GO:0070403 NAD+ binding 8/3944 17/18639 0.470588235294118 2.22395895477867 0.015334455331254 0.0900806550669181 GO:1901567 fatty acid derivative binding 8/3944 17/18639 0.470588235294118 2.22395895477867 0.015334455331254 0.0900806550669181 GO:0034713 type I transforming growth factor beta receptor binding 6/3944 11/18639 0.545454545454545 2.57777060667527 0.0153812551339207 0.0900806550669181 GO:0042608 T cell receptor binding 6/3944 11/18639 0.545454545454545 2.57777060667527 0.0153812551339207 0.0900806550669181 GO:0048185 activin binding 6/3944 11/18639 0.545454545454545 2.57777060667527 0.0153812551339207 0.0900806550669181 GO:0140031 phosphorylation-dependent protein binding 6/3944 11/18639 0.545454545454545 2.57777060667527 0.0153812551339207 0.0900806550669181 GO:0140537 transcription regulator activator activity 6/3944 11/18639 0.545454545454545 2.57777060667527 0.0153812551339207 0.0900806550669181 GO:0005161 platelet-derived growth factor receptor binding 7/3944 14/18639 0.5 2.36295638945233 0.0157999659030998 0.0913414337831566 GO:0044548 S100 protein binding 7/3944 14/18639 0.5 2.36295638945233 0.0157999659030998 0.0913414337831566 GO:0046030 inositol trisphosphate phosphatase activity 7/3944 14/18639 0.5 2.36295638945233 0.0157999659030998 0.0913414337831566 GO:0005044 scavenger receptor activity 11/3944 27/18639 0.407407407407407 1.92537187288709 0.0166005501390294 0.095152940584139 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 11/3944 27/18639 0.407407407407407 1.92537187288709 0.0166005501390294 0.095152940584139 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 13/3944 34/18639 0.382352941176471 1.80696665075767 0.0171974630883615 0.0981567066950122 GO:0004857 enzyme inhibitor activity 106/3944 416/18639 0.254807692307692 1.20419892924013 0.0184797979413884 0.105030750325106 GO:0051010 microtubule plus-end binding 9/3944 21/18639 0.428571428571429 2.02539119095914 0.0205822406928321 0.116244639186538 GO:0004722 protein serine/threonine phosphatase activity 31/3944 103/18639 0.300970873786408 1.42236209850529 0.0206254408059263 0.116244639186538 GO:0061631 ubiquitin conjugating enzyme activity 13/3944 35/18639 0.371428571428571 1.75533903216459 0.0221819953866216 0.124496449107413 GO:0004706 JUN kinase kinase kinase activity 8/3944 18/18639 0.444444444444444 2.10040567951318 0.0225723093422859 0.125640085471319 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 8/3944 18/18639 0.444444444444444 2.10040567951318 0.0225723093422859 0.125640085471319 GO:0004467 long-chain fatty acid-CoA ligase activity 7/3944 15/18639 0.466666666666667 2.20542596348884 0.0243003216256606 0.130712336880415 GO:0005041 low-density lipoprotein particle receptor activity 7/3944 15/18639 0.466666666666667 2.20542596348884 0.0243003216256606 0.130712336880415 GO:0050700 CARD domain binding 7/3944 15/18639 0.466666666666667 2.20542596348884 0.0243003216256606 0.130712336880415 GO:0061578 K63-linked deubiquitinase activity 7/3944 15/18639 0.466666666666667 2.20542596348884 0.0243003216256606 0.130712336880415 GO:0120283 protein serine/threonine kinase binding 7/3944 15/18639 0.466666666666667 2.20542596348884 0.0243003216256606 0.130712336880415 GO:0043539 protein serine/threonine kinase activator activity 23/3944 73/18639 0.315068493150685 1.48898621801106 0.0251569762391513 0.130712336880415 GO:0004709 MAP kinase kinase kinase activity 10/3944 25/18639 0.4 1.89036511156187 0.025186940197987 0.130712336880415 GO:0015645 fatty acid ligase activity 10/3944 25/18639 0.4 1.89036511156187 0.025186940197987 0.130712336880415 GO:0042974 nuclear retinoic acid receptor binding 10/3944 25/18639 0.4 1.89036511156187 0.025186940197987 0.130712336880415 GO:0120515 fatty acid-CoA ligase activity 10/3944 25/18639 0.4 1.89036511156187 0.025186940197987 0.130712336880415 GO:0005025 transforming growth factor beta receptor activity, type I 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:0005026 transforming growth factor beta receptor activity, type II 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:0016361 activin receptor activity, type I 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:0016362 activin receptor activity, type II 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:0017002 activin receptor activity 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:0035259 nuclear glucocorticoid receptor binding 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:0035497 cAMP response element binding 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:0097677 STAT family protein binding 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:1990459 transferrin receptor binding 6/3944 12/18639 0.5 2.36295638945233 0.0253273347630204 0.130712336880415 GO:0050661 NADP binding 18/3944 54/18639 0.333333333333333 1.57530425963489 0.0255905793209161 0.131066579259597 GO:0051287 NAD binding 18/3944 54/18639 0.333333333333333 1.57530425963489 0.0255905793209161 0.131066579259597 GO:0004620 phospholipase activity 32/3944 109/18639 0.293577981651376 1.38742393509128 0.0268352663583368 0.136790209484767 GO:0001784 phosphotyrosine residue binding 16/3944 47/18639 0.340425531914894 1.60882137154201 0.0281004743069459 0.136790209484767 GO:0044390 ubiquitin-like protein conjugating enzyme binding 13/3944 36/18639 0.361111111111111 1.70657961460446 0.0281644196535697 0.136790209484767 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0032931 histone H3K56 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0043992 histone H3K9 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0043993 histone H3K18 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0043994 histone H3K23 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0043999 histone H2AK5 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0044012 histone H2AK9 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0044014 histone H2BK5 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0044015 histone H2BK12 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0044016 histone H3K4 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0044017 histone H3K27 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0044018 histone H3K36 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0046972 histone H4K16 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0140908 histone H3K122 acetyltransferase activity 9/3944 22/18639 0.409090909090909 1.93332795500645 0.0284344904645396 0.136790209484767 GO:0051087 protein-folding chaperone binding 38/3944 134/18639 0.283582089552239 1.34018422088341 0.0291027054523519 0.139140944849081 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 11/3944 29/18639 0.379310344827586 1.79258760579142 0.0291297301020347 0.139140944849081 GO:0030544 Hsp70 protein binding 17/3944 51/18639 0.333333333333333 1.57530425963489 0.0295255116196586 0.140533088875195 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 35/3944 122/18639 0.286885245901639 1.35579464968576 0.0298533103864875 0.140677513928251 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 35/3944 122/18639 0.286885245901639 1.35579464968576 0.0298533103864875 0.140677513928251 GO:0061134 peptidase regulator activity 60/3944 226/18639 0.265486725663717 1.25466710944372 0.0302165766008658 0.140677513928251 GO:0050660 flavin adenine dinucleotide binding 26/3944 86/18639 0.302325581395349 1.42876432850606 0.0303182562777076 0.140677513928251 GO:0032451 demethylase activity 14/3944 40/18639 0.35 1.65406947261663 0.0304957936652185 0.140677513928251 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 14/3944 40/18639 0.35 1.65406947261663 0.0304957936652185 0.140677513928251 GO:0061791 GTPase motor activity 14/3944 40/18639 0.35 1.65406947261663 0.0304957936652185 0.140677513928251 GO:0071949 FAD binding 14/3944 40/18639 0.35 1.65406947261663 0.0304957936652185 0.140677513928251 GO:1990606 membrane scission GTPase motor activity 14/3944 40/18639 0.35 1.65406947261663 0.0304957936652185 0.140677513928251 GO:0097001 ceramide binding 8/3944 19/18639 0.421052631578947 1.98985801217039 0.0319126042719405 0.145223912007783 GO:0120227 acyl-CoA binding 8/3944 19/18639 0.421052631578947 1.98985801217039 0.0319126042719405 0.145223912007783 GO:0140036 ubiquitin-modified protein reader activity 8/3944 19/18639 0.421052631578947 1.98985801217039 0.0319126042719405 0.145223912007783 GO:1990380 K48-linked deubiquitinase activity 8/3944 19/18639 0.421052631578947 1.98985801217039 0.0319126042719405 0.145223912007783 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 12/3944 33/18639 0.363636363636364 1.71851373778351 0.032458510564581 0.146625179660349 GO:0043014 alpha-tubulin binding 15/3944 44/18639 0.340909090909091 1.61110662917204 0.0324615855731489 0.146625179660349 GO:1901682 sulfur compound transmembrane transporter activity 20/3944 63/18639 0.317460317460317 1.50028977108085 0.0325470888778354 0.146625179660349 GO:0042826 histone deacetylase binding 36/3944 127/18639 0.283464566929134 1.33962881921707 0.033159270681419 0.147819048792989 GO:0005160 transforming growth factor beta receptor binding 10/3944 26/18639 0.384615384615385 1.81765876111718 0.0333607949762945 0.147819048792989 GO:0019865 immunoglobulin binding 10/3944 26/18639 0.384615384615385 1.81765876111718 0.0333607949762945 0.147819048792989 GO:0043548 phosphatidylinositol 3-kinase binding 10/3944 26/18639 0.384615384615385 1.81765876111718 0.0333607949762945 0.147819048792989 GO:0070006 metalloaminopeptidase activity 10/3944 26/18639 0.384615384615385 1.81765876111718 0.0333607949762945 0.147819048792989 GO:0032266 phosphatidylinositol-3-phosphate binding 16/3944 48/18639 0.333333333333333 1.57530425963489 0.0341057520942718 0.15013218323851 GO:0140693 molecular condensate scaffold activity 16/3944 48/18639 0.333333333333333 1.57530425963489 0.0341057520942718 0.15013218323851 GO:0008081 phosphoric diester hydrolase activity 26/3944 87/18639 0.298850574712644 1.41234175001749 0.0347888728403077 0.152640429042002 GO:0140030 modification-dependent protein binding 47/3944 173/18639 0.271676300578035 1.28391850062728 0.0349067979716223 0.152660574246024 GO:0043394 proteoglycan binding 13/3944 37/18639 0.351351351351351 1.66045584123677 0.0352418369124524 0.153146599054615 GO:0022858 alanine transmembrane transporter activity 7/3944 16/18639 0.4375 2.06758684077079 0.0354727089124275 0.153146599054615 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 7/3944 16/18639 0.4375 2.06758684077079 0.0354727089124275 0.153146599054615 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 7/3944 16/18639 0.4375 2.06758684077079 0.0354727089124275 0.153146599054615 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 37/3944 132/18639 0.28030303030303 1.32468767287479 0.0365769568509261 0.157409459674752 GO:0043995 histone H4K5 acetyltransferase activity 11/3944 30/18639 0.366666666666667 1.73283468559838 0.037438840546501 0.158558277977713 GO:0043996 histone H4K8 acetyltransferase activity 11/3944 30/18639 0.366666666666667 1.73283468559838 0.037438840546501 0.158558277977713 GO:0043997 histone H4K12 acetyltransferase activity 11/3944 30/18639 0.366666666666667 1.73283468559838 0.037438840546501 0.158558277977713 GO:0098531 ligand-modulated transcription factor activity 19/3944 60/18639 0.316666666666667 1.49653904665314 0.0374894605824182 0.158558277977713 GO:0042169 SH2 domain binding 14/3944 41/18639 0.341463414634146 1.61372631474793 0.0375501786747517 0.158558277977713 GO:0061650 ubiquitin-like protein conjugating enzyme activity 14/3944 41/18639 0.341463414634146 1.61372631474793 0.0375501786747517 0.158558277977713 GO:0044013 histone H2B acetyltransferase activity 9/3944 23/18639 0.391304347826087 1.84927021783226 0.0381656428109382 0.160206506373198 GO:0005035 death receptor activity 6/3944 13/18639 0.461538461538462 2.18119051334061 0.0387730668728007 0.160206506373198 GO:0008035 high-density lipoprotein particle binding 6/3944 13/18639 0.461538461538462 2.18119051334061 0.0387730668728007 0.160206506373198 GO:0035673 oligopeptide transmembrane transporter activity 6/3944 13/18639 0.461538461538462 2.18119051334061 0.0387730668728007 0.160206506373198 GO:0043560 insulin receptor substrate binding 6/3944 13/18639 0.461538461538462 2.18119051334061 0.0387730668728007 0.160206506373198 GO:0051011 microtubule minus-end binding 6/3944 13/18639 0.461538461538462 2.18119051334061 0.0387730668728007 0.160206506373198 GO:0070123 transforming growth factor beta receptor activity, type III 6/3944 13/18639 0.461538461538462 2.18119051334061 0.0387730668728007 0.160206506373198 GO:0031406 carboxylic acid binding 50/3944 187/18639 0.267379679144385 1.26361304248788 0.0396689602499061 0.162674217204576 GO:0043178 alcohol binding 27/3944 92/18639 0.293478260869565 1.3869526633742 0.0396699086163777 0.162674217204576 GO:0051117 ATPase binding 25/3944 84/18639 0.297619047619048 1.40652166038829 0.0397326039052007 0.162674217204576 GO:0090482 vitamin transmembrane transporter activity 12/3944 34/18639 0.352941176470588 1.667969216084 0.0407827182788826 0.163059958090896 GO:0016763 pentosyltransferase activity 16/3944 49/18639 0.326530612244898 1.54315519311173 0.0409951375306704 0.163059958090896 GO:0004090 carbonyl reductase (NADPH) activity 5/3944 10/18639 0.5 2.36295638945233 0.041037361390359 0.163059958090896 GO:0005131 growth hormone receptor binding 5/3944 10/18639 0.5 2.36295638945233 0.041037361390359 0.163059958090896 GO:0005381 iron ion transmembrane transporter activity 5/3944 10/18639 0.5 2.36295638945233 0.041037361390359 0.163059958090896 GO:0005522 profilin binding 5/3944 10/18639 0.5 2.36295638945233 0.041037361390359 0.163059958090896 GO:0016303 1-phosphatidylinositol-3-kinase activity 5/3944 10/18639 0.5 2.36295638945233 0.041037361390359 0.163059958090896 GO:0043208 glycosphingolipid binding 5/3944 10/18639 0.5 2.36295638945233 0.041037361390359 0.163059958090896 GO:0045322 unmethylated CpG binding 5/3944 10/18639 0.5 2.36295638945233 0.041037361390359 0.163059958090896 GO:0051864 histone H3K36 demethylase activity 5/3944 10/18639 0.5 2.36295638945233 0.041037361390359 0.163059958090896 GO:0051018 protein kinase A binding 17/3944 53/18639 0.320754716981132 1.51585881587508 0.0422393005180711 0.167224735105453 GO:0008514 organic anion transmembrane transporter activity 69/3944 269/18639 0.256505576208178 1.21222298046253 0.0431072638056462 0.167224735105453 GO:0016405 CoA-ligase activity 10/3944 27/18639 0.37037037037037 1.75033806626099 0.0432197625276269 0.167224735105453 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 10/3944 27/18639 0.37037037037037 1.75033806626099 0.0432197625276269 0.167224735105453 GO:0015932 nucleobase-containing compound transmembrane transporter activity 18/3944 57/18639 0.315789473684211 1.49239350912779 0.0432239719638929 0.167224735105453 GO:0042887 amide transmembrane transporter activity 13/3944 38/18639 0.342105263157895 1.61675963488844 0.0435029124492494 0.167224735105453 GO:0015095 magnesium ion transmembrane transporter activity 8/3944 20/18639 0.4 1.89036511156187 0.0435752650497506 0.167224735105453 GO:0016004 phospholipase activator activity 8/3944 20/18639 0.4 1.89036511156187 0.0435752650497506 0.167224735105453 GO:0016408 C-acyltransferase activity 8/3944 20/18639 0.4 1.89036511156187 0.0435752650497506 0.167224735105453 GO:0016505 peptidase activator activity involved in apoptotic process 8/3944 20/18639 0.4 1.89036511156187 0.0435752650497506 0.167224735105453 GO:0042288 MHC class I protein binding 8/3944 20/18639 0.4 1.89036511156187 0.0435752650497506 0.167224735105453 GO:0052745 inositol phosphate phosphatase activity 8/3944 20/18639 0.4 1.89036511156187 0.0435752650497506 0.167224735105453 GO:0002039 p53 binding 21/3944 69/18639 0.304347826086957 1.4383212805362 0.0449596710586853 0.169367509644578 GO:0030971 receptor tyrosine kinase binding 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:0033192 calmodulin-dependent protein phosphatase activity 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:0140791 histone H2AXS140 phosphatase activity 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:1990439 MAP kinase serine/threonine phosphatase activity 24/3944 81/18639 0.296296296296296 1.40027045300879 0.0453909955320658 0.169367509644578 GO:0043177 organic acid binding 50/3944 189/18639 0.264550264550265 1.25024147590071 0.0470794165929838 0.175182249035219 GO:0072349 modified amino acid transmembrane transporter activity 11/3944 31/18639 0.354838709677419 1.67693679251456 0.0472683186121939 0.175400620304753 GO:0022853 active monoatomic ion transmembrane transporter activity 33/3944 118/18639 0.279661016949153 1.32165357376147 0.0476295134586237 0.176255369859248 GO:0008484 sulfuric ester hydrolase activity 7/3944 17/18639 0.411764705882353 1.94596408543133 0.049569486419249 0.180320185316602 GO:0016805 dipeptidase activity 7/3944 17/18639 0.411764705882353 1.94596408543133 0.049569486419249 0.180320185316602 GO:0030169 low-density lipoprotein particle binding 7/3944 17/18639 0.411764705882353 1.94596408543133 0.049569486419249 0.180320185316602 GO:0036041 long-chain fatty acid binding 7/3944 17/18639 0.411764705882353 1.94596408543133 0.049569486419249 0.180320185316602 GO:0048038 quinone binding 7/3944 17/18639 0.411764705882353 1.94596408543133 0.049569486419249 0.180320185316602 GO:0004622 lysophospholipase activity 9/3944 24/18639 0.375 1.77221729208925 0.0499327610416427 0.180320185316602 GO:0035035 histone acetyltransferase binding 9/3944 24/18639 0.375 1.77221729208925 0.0499327610416427 0.180320185316602 GO:0043998 histone H2A acetyltransferase activity 9/3944 24/18639 0.375 1.77221729208925 0.0499327610416427 0.180320185316602 GO:0060229 lipase activator activity 9/3944 24/18639 0.375 1.77221729208925 0.0499327610416427 0.180320185316602 GO:0016229 steroid dehydrogenase activity 12/3944 35/18639 0.342857142857143 1.62031295276731 0.0504874432661492 0.181835791656425 GO:0008235 metalloexopeptidase activity 20/3944 66/18639 0.303030303030303 1.43209478148626 0.0516311387515692 0.184792888171142 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 24/3944 82/18639 0.292682926829268 1.38319398406966 0.0517200585304532 0.184792888171142 GO:0033549 MAP kinase phosphatase activity 24/3944 82/18639 0.292682926829268 1.38319398406966 0.0517200585304532 0.184792888171142 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 13/3944 39/18639 0.333333333333333 1.57530425963489 0.0530251862077796 0.188954830216611 GO:0019789 SUMO transferase activity 10/3944 28/18639 0.357142857142857 1.68782599246595 0.0548823935494237 0.193525089296005 GO:0036408 histone H3K14 acetyltransferase activity 10/3944 28/18639 0.357142857142857 1.68782599246595 0.0548823935494237 0.193525089296005 GO:0046625 sphingolipid binding 10/3944 28/18639 0.357142857142857 1.68782599246595 0.0548823935494237 0.193525089296005 GO:0046966 nuclear thyroid hormone receptor binding 10/3944 28/18639 0.357142857142857 1.68782599246595 0.0548823935494237 0.193525089296005 GO:0008191 metalloendopeptidase inhibitor activity 6/3944 14/18639 0.428571428571429 2.02539119095914 0.0560028926000763 0.194422413227584 GO:0019763 immunoglobulin receptor activity 6/3944 14/18639 0.428571428571429 2.02539119095914 0.0560028926000763 0.194422413227584 GO:0034236 protein kinase A catalytic subunit binding 6/3944 14/18639 0.428571428571429 2.02539119095914 0.0560028926000763 0.194422413227584 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 6/3944 14/18639 0.428571428571429 2.02539119095914 0.0560028926000763 0.194422413227584 GO:0071933 Arp2/3 complex binding 6/3944 14/18639 0.428571428571429 2.02539119095914 0.0560028926000763 0.194422413227584 GO:0098821 BMP receptor activity 6/3944 14/18639 0.428571428571429 2.02539119095914 0.0560028926000763 0.194422413227584 GO:0061733 protein-lysine-acetyltransferase activity 15/3944 47/18639 0.319148936170213 1.50827003582064 0.0565174059999881 0.195704231059085 GO:0005123 death receptor binding 8/3944 21/18639 0.380952380952381 1.80034772529702 0.0577248185001621 0.197948602232205 GO:0008373 sialyltransferase activity 8/3944 21/18639 0.380952380952381 1.80034772529702 0.0577248185001621 0.197948602232205 GO:0072542 protein phosphatase activator activity 8/3944 21/18639 0.380952380952381 1.80034772529702 0.0577248185001621 0.197948602232205 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 117/3944 484/18639 0.241735537190083 1.142421064322 0.057753378379552 0.197948602232205 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 24/3944 83/18639 0.289156626506024 1.36652899630978 0.0586582385573669 0.199708459014002 GO:0071813 lipoprotein particle binding 11/3944 32/18639 0.34375 1.62453251774848 0.0587116182401967 0.199708459014002 GO:0071814 protein-lipid complex binding 11/3944 32/18639 0.34375 1.62453251774848 0.0587116182401967 0.199708459014002 GO:0004879 nuclear receptor activity 18/3944 59/18639 0.305084745762712 1.44180389864888 0.0590087175618166 0.199710408431575 GO:0031593 polyubiquitin modification-dependent protein binding 18/3944 59/18639 0.305084745762712 1.44180389864888 0.0590087175618166 0.199710408431575 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 20/3944 67/18639 0.298507462686567 1.41072023250886 0.0594680787987783 0.20076065699738 GO:0005225 volume-sensitive anion channel activity 5/3944 11/18639 0.454545454545455 2.14814217222939 0.0624174499373909 0.206575688122028 GO:0015173 aromatic amino acid transmembrane transporter activity 5/3944 11/18639 0.454545454545455 2.14814217222939 0.0624174499373909 0.206575688122028 GO:0016176 superoxide-generating NADPH oxidase activator activity 5/3944 11/18639 0.454545454545455 2.14814217222939 0.0624174499373909 0.206575688122028 GO:0019107 myristoyltransferase activity 5/3944 11/18639 0.454545454545455 2.14814217222939 0.0624174499373909 0.206575688122028 GO:0019203 carbohydrate phosphatase activity 5/3944 11/18639 0.454545454545455 2.14814217222939 0.0624174499373909 0.206575688122028 GO:0032050 clathrin heavy chain binding 5/3944 11/18639 0.454545454545455 2.14814217222939 0.0624174499373909 0.206575688122028 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 5/3944 11/18639 0.454545454545455 2.14814217222939 0.0624174499373909 0.206575688122028 GO:0180030 inositol phosphate kinase activity 5/3944 11/18639 0.454545454545455 2.14814217222939 0.0624174499373909 0.206575688122028 GO:0015662 P-type ion transporter activity 9/3944 25/18639 0.36 1.70132860040568 0.0638522852661989 0.20875977731449 GO:0019706 protein-cysteine S-palmitoyltransferase activity 9/3944 25/18639 0.36 1.70132860040568 0.0638522852661989 0.20875977731449 GO:0019707 protein-cysteine S-acyltransferase activity 9/3944 25/18639 0.36 1.70132860040568 0.0638522852661989 0.20875977731449 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 9/3944 25/18639 0.36 1.70132860040568 0.0638522852661989 0.20875977731449 GO:0140358 P-type transmembrane transporter activity 9/3944 25/18639 0.36 1.70132860040568 0.0638522852661989 0.20875977731449 GO:0001216 DNA-binding transcription activator activity 118/3944 491/18639 0.240325865580448 1.13575907924796 0.0653979609280457 0.213295528741108 GO:0017018 myosin phosphatase activity 24/3944 84/18639 0.285714285714286 1.35026079397276 0.0662284924182335 0.215482558665122 GO:0000900 mRNA regulatory element binding translation repressor activity 7/3944 18/18639 0.388888888888889 1.83785496957404 0.0667495081954982 0.216654427805629 GO:0005080 protein kinase C binding 16/3944 52/18639 0.307692307692308 1.45412700889374 0.0675071561020524 0.218586873243905 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 18/3944 60/18639 0.3 1.4177738336714 0.0682312562672729 0.220009229336357 GO:0010484 histone H3 acetyltransferase activity 10/3944 29/18639 0.344827586206897 1.62962509617402 0.0684364269427865 0.220009229336357 GO:0043236 laminin binding 10/3944 29/18639 0.344827586206897 1.62962509617402 0.0684364269427865 0.220009229336357 GO:0140416 transcription regulator inhibitor activity 11/3944 33/18639 0.333333333333333 1.57530425963489 0.0718381720780044 0.230395280450171 GO:0008093 cytoskeletal anchor activity 8/3944 22/18639 0.363636363636364 1.71851373778351 0.0744621488062321 0.237678944175343 GO:0016881 acid-amino acid ligase activity 8/3944 22/18639 0.363636363636364 1.71851373778351 0.0744621488062321 0.237678944175343 GO:0001530 lipopolysaccharide binding 13/3944 41/18639 0.317073170731707 1.4984601494088 0.0760938288920096 0.241172676511851 GO:0016877 ligase activity, forming carbon-sulfur bonds 13/3944 41/18639 0.317073170731707 1.4984601494088 0.0760938288920096 0.241172676511851 GO:0140318 protein transporter activity 13/3944 41/18639 0.317073170731707 1.4984601494088 0.0760938288920096 0.241172676511851 GO:0015929 hexosaminidase activity 6/3944 15/18639 0.4 1.89036511156187 0.0771379399163536 0.243907993115794 GO:0015026 coreceptor activity 18/3944 61/18639 0.295081967213115 1.39453163967679 0.0783805891337917 0.247256799913858 GO:0001637 G protein-coupled chemoattractant receptor activity 9/3944 26/18639 0.346153846153846 1.63589288500546 0.0799948389490897 0.248852304998669 GO:0004112 cyclic-nucleotide phosphodiesterase activity 9/3944 26/18639 0.346153846153846 1.63589288500546 0.0799948389490897 0.248852304998669 GO:0004950 chemokine receptor activity 9/3944 26/18639 0.346153846153846 1.63589288500546 0.0799948389490897 0.248852304998669 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 9/3944 26/18639 0.346153846153846 1.63589288500546 0.0799948389490897 0.248852304998669 GO:0008198 ferrous iron binding 9/3944 26/18639 0.346153846153846 1.63589288500546 0.0799948389490897 0.248852304998669 GO:0034237 protein kinase A regulatory subunit binding 9/3944 26/18639 0.346153846153846 1.63589288500546 0.0799948389490897 0.248852304998669 GO:0031420 alkali metal ion binding 7/3944 19/18639 0.368421052631579 1.74112576064909 0.0870710354842404 0.270241209210304 GO:0016758 hexosyltransferase activity 50/3944 197/18639 0.253807106598985 1.19947024845296 0.0872777282887715 0.270260000011437 GO:0004126 cytidine deaminase activity 5/3944 12/18639 0.416666666666667 1.96913032454361 0.0889103893476554 0.272187032843845 GO:0005095 GTPase inhibitor activity 5/3944 12/18639 0.416666666666667 1.96913032454361 0.0889103893476554 0.272187032843845 GO:0008603 cAMP-dependent protein kinase regulator activity 5/3944 12/18639 0.416666666666667 1.96913032454361 0.0889103893476554 0.272187032843845 GO:0034452 dynactin binding 5/3944 12/18639 0.416666666666667 1.96913032454361 0.0889103893476554 0.272187032843845 GO:0070410 co-SMAD binding 5/3944 12/18639 0.416666666666667 1.96913032454361 0.0889103893476554 0.272187032843845 GO:0019894 kinesin binding 13/3944 42/18639 0.30952380952381 1.46278252680383 0.0897199813714658 0.274042664189035 GO:0004180 carboxypeptidase activity 14/3944 46/18639 0.304347826086957 1.4383212805362 0.0903551085673971 0.275033618719599 GO:0140463 chromatin-protein adaptor activity 16/3944 54/18639 0.296296296296296 1.40027045300879 0.0904527788365124 0.275033618719599 GO:0045296 cadherin binding 81/3944 334/18639 0.24251497005988 1.14610459608167 0.0934815483823005 0.282089116850477 GO:0015078 proton transmembrane transporter activity 47/3944 185/18639 0.254054054054054 1.20063730058659 0.0935988047509312 0.282089116850477 GO:0004602 glutathione peroxidase activity 8/3944 23/18639 0.347826086956522 1.64379574918423 0.0938202853370555 0.282089116850477 GO:0005158 insulin receptor binding 8/3944 23/18639 0.347826086956522 1.64379574918423 0.0938202853370555 0.282089116850477 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 8/3944 23/18639 0.347826086956522 1.64379574918423 0.0938202853370555 0.282089116850477 GO:0033293 monocarboxylic acid binding 22/3944 79/18639 0.278481012658228 1.31607697640383 0.0960215661004634 0.28806469830139 GO:0004683 calcium/calmodulin-dependent protein kinase activity 9/3944 27/18639 0.333333333333333 1.57530425963489 0.0983823771598212 0.293838275020575 GO:0005385 zinc ion transmembrane transporter activity 9/3944 27/18639 0.333333333333333 1.57530425963489 0.0983823771598212 0.293838275020575 GO:0015085 calcium ion transmembrane transporter activity 38/3944 147/18639 0.258503401360544 1.22166452788012 0.0993485346131963 0.296067425053043 GO:0050840 extracellular matrix binding 19/3944 67/18639 0.283582089552239 1.34018422088341 0.100292380037482 0.298220388323373 GO:0016878 acid-thiol ligase activity 10/3944 31/18639 0.32258064516129 1.52448799319505 0.101395649440327 0.298548318658038 GO:0005024 transforming growth factor beta receptor activity 6/3944 16/18639 0.375 1.77221729208925 0.102137078518709 0.298548318658038 GO:0008142 oxysterol binding 6/3944 16/18639 0.375 1.77221729208925 0.102137078518709 0.298548318658038 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 6/3944 16/18639 0.375 1.77221729208925 0.102137078518709 0.298548318658038 GO:0016722 oxidoreductase activity, acting on metal ions 6/3944 16/18639 0.375 1.77221729208925 0.102137078518709 0.298548318658038 GO:0070411 I-SMAD binding 6/3944 16/18639 0.375 1.77221729208925 0.102137078518709 0.298548318658038 GO:0140328 floppase activity 6/3944 16/18639 0.375 1.77221729208925 0.102137078518709 0.298548318658038 GO:0001786 phosphatidylserine binding 17/3944 59/18639 0.288135593220339 1.36170368205728 0.102643749175613 0.298548318658038 GO:0045309 protein phosphorylated amino acid binding 17/3944 59/18639 0.288135593220339 1.36170368205728 0.102643749175613 0.298548318658038 GO:0016651 oxidoreductase activity, acting on NAD(P)H 24/3944 88/18639 0.272727272727273 1.28888530333764 0.103177035669207 0.298548318658038 GO:0005154 epidermal growth factor receptor binding 11/3944 35/18639 0.314285714285714 1.48528687337004 0.103283976610724 0.298548318658038 GO:0010485 histone H4 acetyltransferase activity 11/3944 35/18639 0.314285714285714 1.48528687337004 0.103283976610724 0.298548318658038 GO:0140566 histone reader activity 11/3944 35/18639 0.314285714285714 1.48528687337004 0.103283976610724 0.298548318658038 GO:0003714 transcription corepressor activity 51/3944 204/18639 0.25 1.18147819472617 0.104632078722487 0.300735693347909 GO:0043495 protein-membrane adaptor activity 14/3944 47/18639 0.297872340425532 1.40771870009926 0.104710497535389 0.300735693347909 GO:0140359 ABC-type transporter activity 14/3944 47/18639 0.297872340425532 1.40771870009926 0.104710497535389 0.300735693347909 GO:0030742 GTP-dependent protein binding 7/3944 20/18639 0.35 1.65406947261663 0.110491834948966 0.316664897183525 GO:0042379 chemokine receptor binding 20/3944 72/18639 0.277777777777778 1.31275354969574 0.110924281015825 0.317229313223601 GO:0019783 ubiquitin-like protein peptidase activity 33/3944 127/18639 0.259842519685039 1.22799308428231 0.111625889266099 0.318306079650202 GO:0051219 phosphoprotein binding 25/3944 93/18639 0.268817204301075 1.27040666099588 0.111773404361207 0.318306079650202 GO:0005548 phospholipid transporter activity 19/3944 68/18639 0.279411764705882 1.32047562939983 0.112776740150162 0.32048579954065 GO:0046943 carboxylic acid transmembrane transporter activity 47/3944 188/18639 0.25 1.18147819472617 0.115201659385701 0.322845076525825 GO:0044325 transmembrane transporter binding 35/3944 136/18639 0.257352941176471 1.21622755339458 0.115414359298967 0.322845076525825 GO:0001091 RNA polymerase II general transcription initiation factor binding 8/3944 24/18639 0.333333333333333 1.57530425963489 0.115764047484761 0.322845076525825 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 8/3944 24/18639 0.333333333333333 1.57530425963489 0.115764047484761 0.322845076525825 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 8/3944 24/18639 0.333333333333333 1.57530425963489 0.115764047484761 0.322845076525825 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 8/3944 24/18639 0.333333333333333 1.57530425963489 0.115764047484761 0.322845076525825 GO:0019957 C-C chemokine binding 8/3944 24/18639 0.333333333333333 1.57530425963489 0.115764047484761 0.322845076525825 GO:0050699 WW domain binding 8/3944 24/18639 0.333333333333333 1.57530425963489 0.115764047484761 0.322845076525825 GO:0140033 acetylation-dependent protein binding 8/3944 24/18639 0.333333333333333 1.57530425963489 0.115764047484761 0.322845076525825 GO:0170055 lipid transmembrane transporter activity 16/3944 56/18639 0.285714285714286 1.35026079397276 0.117808927343346 0.327826881611521 GO:0061135 endopeptidase regulator activity 46/3944 184/18639 0.25 1.18147819472617 0.118037147425084 0.327826881611521 GO:0030159 signaling receptor complex adaptor activity 15/3944 52/18639 0.288461538461538 1.36324407083788 0.119198034792259 0.329881166618758 GO:0005338 nucleotide-sugar transmembrane transporter activity 5/3944 13/18639 0.384615384615385 1.81765876111718 0.12024621589444 0.329881166618758 GO:0015651 quaternary ammonium group transmembrane transporter activity 5/3944 13/18639 0.384615384615385 1.81765876111718 0.12024621589444 0.329881166618758 GO:0030955 potassium ion binding 5/3944 13/18639 0.384615384615385 1.81765876111718 0.12024621589444 0.329881166618758 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 5/3944 13/18639 0.384615384615385 1.81765876111718 0.12024621589444 0.329881166618758 GO:0140852 histone ubiquitin ligase activity 5/3944 13/18639 0.384615384615385 1.81765876111718 0.12024621589444 0.329881166618758 GO:0022884 macromolecule transmembrane transporter activity 10/3944 32/18639 0.3125 1.47684774340771 0.120797481804022 0.330049103428029 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 10/3944 32/18639 0.3125 1.47684774340771 0.120797481804022 0.330049103428029 GO:0031490 chromatin DNA binding 33/3944 128/18639 0.2578125 1.21839938831136 0.121107654556481 0.330226742282549 GO:0004033 aldo-keto reductase (NADPH) activity 11/3944 36/18639 0.305555555555556 1.44402890466531 0.12160338608757 0.330241453749913 GO:0016409 palmitoyltransferase activity 11/3944 36/18639 0.305555555555556 1.44402890466531 0.12160338608757 0.330241453749913 GO:0005342 organic acid transmembrane transporter activity 47/3944 189/18639 0.248677248677249 1.17522698734666 0.123067826975602 0.333546001883574 GO:0160215 deacylase activity 18/3944 65/18639 0.276923076923077 1.30871430800437 0.128546835889047 0.347695959723987 GO:0005092 GDP-dissociation inhibitor activity 6/3944 17/18639 0.352941176470588 1.667969216084 0.13081031057296 0.349791164115118 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/3944 17/18639 0.352941176470588 1.667969216084 0.13081031057296 0.349791164115118 GO:0032977 membrane insertase activity 6/3944 17/18639 0.352941176470588 1.667969216084 0.13081031057296 0.349791164115118 GO:0038191 neuropilin binding 6/3944 17/18639 0.352941176470588 1.667969216084 0.13081031057296 0.349791164115118 GO:0051787 misfolded protein binding 6/3944 17/18639 0.352941176470588 1.667969216084 0.13081031057296 0.349791164115118 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 17/3944 61/18639 0.278688524590164 1.31705765969474 0.130879544702316 0.349791164115118 GO:0034212 protein N-acetyltransferase activity 15/3944 53/18639 0.283018867924528 1.33752248459566 0.135289181543972 0.355843624864437 GO:0140296 general transcription initiation factor binding 15/3944 53/18639 0.283018867924528 1.33752248459566 0.135289181543972 0.355843624864437 GO:0004843 cysteine-type deubiquitinase activity 28/3944 108/18639 0.259259259259259 1.22523664638269 0.13683552884588 0.355843624864437 GO:0019200 carbohydrate kinase activity 7/3944 21/18639 0.333333333333333 1.57530425963489 0.136875343173368 0.355843624864437 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 7/3944 21/18639 0.333333333333333 1.57530425963489 0.136875343173368 0.355843624864437 GO:0048029 monosaccharide binding 20/3944 74/18639 0.27027027027027 1.27727372402829 0.137445507962797 0.355843624864437 GO:0008009 chemokine activity 13/3944 45/18639 0.288888888888889 1.36526369168357 0.139065037746286 0.355843624864437 GO:0140303 intramembrane lipid transporter activity 13/3944 45/18639 0.288888888888889 1.36526369168357 0.139065037746286 0.355843624864437 GO:0141110 transporter inhibitor activity 13/3944 45/18639 0.288888888888889 1.36526369168357 0.139065037746286 0.355843624864437 GO:0008139 nuclear localization sequence binding 8/3944 25/18639 0.32 1.51229208924949 0.140193112058203 0.355843624864437 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 8/3944 25/18639 0.32 1.51229208924949 0.140193112058203 0.355843624864437 GO:0019211 phosphatase activator activity 8/3944 25/18639 0.32 1.51229208924949 0.140193112058203 0.355843624864437 GO:0047617 fatty acyl-CoA hydrolase activity 8/3944 25/18639 0.32 1.51229208924949 0.140193112058203 0.355843624864437 GO:0042287 MHC protein binding 12/3944 41/18639 0.292682926829268 1.38319398406966 0.140544282557555 0.355843624864437 GO:0019208 phosphatase regulator activity 30/3944 117/18639 0.256410256410256 1.21177250741145 0.141295958695694 0.355843624864437 GO:0016417 S-acyltransferase activity 9/3944 29/18639 0.310344827586207 1.46666258655662 0.141735675079365 0.355843624864437 GO:0099604 ligand-gated calcium channel activity 9/3944 29/18639 0.310344827586207 1.46666258655662 0.141735675079365 0.355843624864437 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0004445 inositol-polyphosphate 5-phosphatase activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0004862 cAMP-dependent protein kinase inhibitor activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0005031 tumor necrosis factor receptor activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0005345 purine nucleobase transmembrane transporter activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0015279 store-operated calcium channel activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0016175 superoxide-generating NAD(P)H oxidase activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0030957 Tat protein binding 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0031434 mitogen-activated protein kinase kinase binding 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0031957 very long-chain fatty acid-CoA ligase activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0050308 sugar-phosphatase activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0071723 lipopeptide binding 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0140999 histone H3K4 trimethyltransferase activity 4/3944 10/18639 0.4 1.89036511156187 0.142126110005246 0.355843624864437 GO:0030165 PDZ domain binding 22/3944 83/18639 0.265060240963855 1.25265157995063 0.144890077784158 0.362090788080262 GO:0005178 integrin binding 40/3944 161/18639 0.248447204968944 1.17413982084588 0.146520549458515 0.365487370593739 GO:0015297 antiporter activity 34/3944 135/18639 0.251851851851852 1.19022988505747 0.148596179451629 0.369979766582891 GO:0052689 carboxylic ester hydrolase activity 24/3944 92/18639 0.260869565217391 1.23284681188817 0.151167996697571 0.375688729800051 GO:0015631 tubulin binding 90/3944 385/18639 0.233766233766234 1.10475883143226 0.155545739471343 0.383297578604182 GO:0008474 palmitoyl-(protein) hydrolase activity 5/3944 14/18639 0.357142857142857 1.68782599246595 0.155936951057975 0.383297578604182 GO:0032454 histone H3K9 demethylase activity 5/3944 14/18639 0.357142857142857 1.68782599246595 0.155936951057975 0.383297578604182 GO:0061665 SUMO ligase activity 5/3944 14/18639 0.357142857142857 1.68782599246595 0.155936951057975 0.383297578604182 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 5/3944 14/18639 0.357142857142857 1.68782599246595 0.155936951057975 0.383297578604182 GO:0098599 palmitoyl hydrolase activity 5/3944 14/18639 0.357142857142857 1.68782599246595 0.155936951057975 0.383297578604182 GO:0016779 nucleotidyltransferase activity 34/3944 136/18639 0.25 1.18147819472617 0.159656786169183 0.391726213059907 GO:0004402 histone acetyltransferase activity 12/3944 42/18639 0.285714285714286 1.35026079397276 0.160874003031991 0.393995058334712 GO:0008194 UDP-glycosyltransferase activity 36/3944 145/18639 0.248275862068966 1.1733300692453 0.16240857022989 0.394507983350715 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 6/3944 18/18639 0.333333333333333 1.57530425963489 0.162840711761691 0.394507983350715 GO:0016854 racemase and epimerase activity 6/3944 18/18639 0.333333333333333 1.57530425963489 0.162840711761691 0.394507983350715 GO:0017075 syntaxin-1 binding 6/3944 18/18639 0.333333333333333 1.57530425963489 0.162840711761691 0.394507983350715 GO:0034185 apolipoprotein binding 6/3944 18/18639 0.333333333333333 1.57530425963489 0.162840711761691 0.394507983350715 GO:0050811 GABA receptor binding 6/3944 18/18639 0.333333333333333 1.57530425963489 0.162840711761691 0.394507983350715 GO:0043531 ADP binding 11/3944 38/18639 0.289473684210526 1.36802738336714 0.163221610351319 0.394720842267912 GO:0004407 histone deacetylase activity 7/3944 22/18639 0.318181818181818 1.50369952056058 0.166001500544697 0.396611678031255 GO:0008970 phospholipase A1 activity 7/3944 22/18639 0.318181818181818 1.50369952056058 0.166001500544697 0.396611678031255 GO:0033558 protein lysine deacetylase activity 7/3944 22/18639 0.318181818181818 1.50369952056058 0.166001500544697 0.396611678031255 GO:0001965 G-protein alpha-subunit binding 9/3944 30/18639 0.3 1.4177738336714 0.166507298624409 0.396611678031255 GO:0008106 alcohol dehydrogenase (NADP+) activity 9/3944 30/18639 0.3 1.4177738336714 0.166507298624409 0.396611678031255 GO:0015215 nucleotide transmembrane transporter activity 9/3944 30/18639 0.3 1.4177738336714 0.166507298624409 0.396611678031255 GO:0031210 phosphatidylcholine binding 9/3944 30/18639 0.3 1.4177738336714 0.166507298624409 0.396611678031255 GO:0051721 protein phosphatase 2A binding 9/3944 30/18639 0.3 1.4177738336714 0.166507298624409 0.396611678031255 GO:0016289 acyl-CoA hydrolase activity 8/3944 26/18639 0.307692307692308 1.45412700889374 0.166947900106697 0.396611678031255 GO:0120014 phospholipid transfer activity 8/3944 26/18639 0.307692307692308 1.45412700889374 0.166947900106697 0.396611678031255 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 32/3944 128/18639 0.25 1.18147819472617 0.168290263022592 0.399096803329986 GO:0101005 deubiquitinase activity 29/3944 115/18639 0.252173913043478 1.19175191815857 0.16938788260793 0.400993809969916 GO:0015171 amino acid transmembrane transporter activity 26/3944 102/18639 0.254901960784314 1.20464443383844 0.169813670578881 0.401296516262725 GO:0005518 collagen binding 19/3944 72/18639 0.263888888888889 1.24711587221095 0.171645087677491 0.404914068479125 GO:0015293 symporter activity 36/3944 146/18639 0.246575342465753 1.1652935619217 0.173662274440103 0.40895643998395 GO:0005504 fatty acid binding 13/3944 47/18639 0.276595744680851 1.30716736437789 0.178726236033965 0.419519140953755 GO:0019888 protein phosphatase regulator activity 27/3944 107/18639 0.252336448598131 1.19252004701333 0.178770591616522 0.419519140953755 GO:0000099 sulfur amino acid transmembrane transporter activity 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0002162 dystroglycan binding 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0005114 type II transforming growth factor beta receptor binding 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0005536 D-glucose binding 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0008432 JUN kinase binding 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0015205 nucleobase transmembrane transporter activity 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0032794 GTPase activating protein binding 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0097493 structural molecule activity conferring elasticity 4/3944 11/18639 0.363636363636364 1.71851373778351 0.187673915758307 0.432871172134314 GO:0004521 RNA endonuclease activity 19/3944 73/18639 0.26027397260274 1.23003209313957 0.188493385804656 0.434018103724568 GO:0008080 N-acetyltransferase activity 18/3944 69/18639 0.260869565217391 1.23284681188817 0.193745246286619 0.441819596465331 GO:0004865 protein serine/threonine phosphatase inhibitor activity 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0005402 carbohydrate:monoatomic cation symporter activity 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0017081 chloride channel regulator activity 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0050780 dopamine receptor binding 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0051371 muscle alpha-actinin binding 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0140776 protein-containing complex destabilizing activity 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0141050 histone H3K deacetylase activity 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0141051 histone H4K deacetylase activity 5/3944 15/18639 0.333333333333333 1.57530425963489 0.195336456628786 0.441819596465331 GO:0001671 ATPase activator activity 8/3944 27/18639 0.296296296296296 1.40027045300879 0.195817593979067 0.441819596465331 GO:0035255 ionotropic glutamate receptor binding 8/3944 27/18639 0.296296296296296 1.40027045300879 0.195817593979067 0.441819596465331 GO:0003887 DNA-directed DNA polymerase activity 7/3944 23/18639 0.304347826086957 1.4383212805362 0.197580782198041 0.442611069171137 GO:0016493 C-C chemokine receptor activity 7/3944 23/18639 0.304347826086957 1.4383212805362 0.197580782198041 0.442611069171137 GO:0043274 phospholipase binding 7/3944 23/18639 0.304347826086957 1.4383212805362 0.197580782198041 0.442611069171137 GO:0070577 lysine-acetylated histone binding 7/3944 23/18639 0.304347826086957 1.4383212805362 0.197580782198041 0.442611069171137 GO:0070003 threonine-type peptidase activity 6/3944 19/18639 0.315789473684211 1.49239350912779 0.197811331582052 0.442611069171137 GO:0072341 modified amino acid binding 23/3944 91/18639 0.252747252747253 1.19446147159129 0.199779254078399 0.446273060105479 GO:0001046 core promoter sequence-specific DNA binding 12/3944 44/18639 0.272727272727273 1.28888530333764 0.205608846387517 0.456268725014802 GO:0001223 transcription coactivator binding 12/3944 44/18639 0.272727272727273 1.28888530333764 0.205608846387517 0.456268725014802 GO:0016248 channel inhibitor activity 12/3944 44/18639 0.272727272727273 1.28888530333764 0.205608846387517 0.456268725014802 GO:0016790 thiolester hydrolase activity 12/3944 44/18639 0.272727272727273 1.28888530333764 0.205608846387517 0.456268725014802 GO:0008028 monocarboxylic acid transmembrane transporter activity 18/3944 70/18639 0.257142857142857 1.21523471457549 0.212192168181682 0.470103372599879 GO:0004190 aspartic-type endopeptidase activity 10/3944 36/18639 0.277777777777778 1.31275354969574 0.216191459812803 0.478177169733737 GO:0042910 xenobiotic transmembrane transporter activity 9/3944 32/18639 0.28125 1.32916296906694 0.221453343477081 0.487414466770634 GO:0043425 bHLH transcription factor binding 9/3944 32/18639 0.28125 1.32916296906694 0.221453343477081 0.487414466770634 GO:0051059 NF-kappaB binding 9/3944 32/18639 0.28125 1.32916296906694 0.221453343477081 0.487414466770634 GO:0008017 microtubule binding 64/3944 276/18639 0.231884057971014 1.09586383278949 0.222755807636165 0.489481358704591 GO:0060590 ATPase regulator activity 13/3944 49/18639 0.26530612244898 1.25381359440328 0.223198397251851 0.489655115795185 GO:0046875 ephrin receptor binding 8/3944 28/18639 0.285714285714286 1.35026079397276 0.226549578549005 0.495393315431023 GO:0051959 dynein light intermediate chain binding 8/3944 28/18639 0.285714285714286 1.35026079397276 0.226549578549005 0.495393315431023 GO:0005315 phosphate transmembrane transporter activity 7/3944 24/18639 0.291666666666667 1.37839122718053 0.231270025903509 0.502452782083913 GO:0030215 semaphorin receptor binding 7/3944 24/18639 0.291666666666667 1.37839122718053 0.231270025903509 0.502452782083913 GO:0050431 transforming growth factor beta binding 7/3944 24/18639 0.291666666666667 1.37839122718053 0.231270025903509 0.502452782083913 GO:0070300 phosphatidic acid binding 7/3944 24/18639 0.291666666666667 1.37839122718053 0.231270025903509 0.502452782083913 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 6/3944 20/18639 0.3 1.4177738336714 0.235233972996233 0.502639944261464 GO:0015175 neutral L-amino acid transmembrane transporter activity 11/3944 41/18639 0.268292682926829 1.26792781873052 0.236677550135372 0.502639944261464 GO:0005078 MAP-kinase scaffold activity 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0015269 calcium-activated potassium channel activity 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0015368 calcium:monoatomic cation antiporter activity 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0016208 AMP binding 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0016423 tRNA (guanine) methyltransferase activity 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0035251 UDP-glucosyltransferase activity 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 4/3944 12/18639 0.333333333333333 1.57530425963489 0.237055678963633 0.502639944261464 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 5/3944 16/18639 0.3125 1.47684774340771 0.237699810315184 0.502639944261464 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 5/3944 16/18639 0.3125 1.47684774340771 0.237699810315184 0.502639944261464 GO:0005159 insulin-like growth factor receptor binding 5/3944 16/18639 0.3125 1.47684774340771 0.237699810315184 0.502639944261464 GO:0005521 lamin binding 5/3944 16/18639 0.3125 1.47684774340771 0.237699810315184 0.502639944261464 GO:0140327 flippase activity 5/3944 16/18639 0.3125 1.47684774340771 0.237699810315184 0.502639944261464 GO:0019213 deacetylase activity 10/3944 37/18639 0.27027027027027 1.27727372402829 0.243815687157167 0.513958889828957 GO:0070001 aspartic-type peptidase activity 10/3944 37/18639 0.27027027027027 1.27727372402829 0.243815687157167 0.513958889828957 GO:0005507 copper ion binding 16/3944 63/18639 0.253968253968254 1.20023181686468 0.246250453964156 0.518280252327684 GO:0042393 histone binding 57/3944 247/18639 0.230769230769231 1.09059525667031 0.250702636217108 0.5268275366372 GO:0030296 protein tyrosine kinase activator activity 9/3944 33/18639 0.272727272727273 1.28888530333764 0.251216795453497 0.527085706348692 GO:0070063 RNA polymerase binding 15/3944 59/18639 0.254237288135593 1.20150324887407 0.254264647758363 0.532650825086337 GO:0030291 protein serine/threonine kinase inhibitor activity 12/3944 46/18639 0.260869565217391 1.23284681188817 0.255060523428497 0.533488392947493 GO:0004629 phospholipase C activity 8/3944 29/18639 0.275862068965517 1.30370007693922 0.25885963701363 0.539758407209535 GO:0035250 UDP-galactosyltransferase activity 8/3944 29/18639 0.275862068965517 1.30370007693922 0.25885963701363 0.539758407209535 GO:1990841 promoter-specific chromatin binding 17/3944 68/18639 0.25 1.18147819472617 0.259485165237727 0.540226456839596 GO:0005516 calmodulin binding 48/3944 207/18639 0.231884057971014 1.09586383278949 0.260270816391478 0.541025909998953 GO:0051879 Hsp90 protein binding 11/3944 42/18639 0.261904761904762 1.2377390611417 0.263575582978507 0.547051325534744 GO:0000030 mannosyltransferase activity 7/3944 25/18639 0.28 1.32325557809331 0.266688825732239 0.551812362920623 GO:0017025 TBP-class protein binding 7/3944 25/18639 0.28 1.32325557809331 0.266688825732239 0.551812362920623 GO:0009931 calcium-dependent protein serine/threonine kinase activity 6/3944 21/18639 0.285714285714286 1.35026079397276 0.274577424925379 0.567113184250898 GO:0004175 endopeptidase activity 91/3944 405/18639 0.224691358024691 1.06187176019833 0.274925693627198 0.567113184250898 GO:0140938 histone H3 methyltransferase activity 12/3944 47/18639 0.25531914893617 1.20661602865651 0.281232279106622 0.573413840459843 GO:0004659 prenyltransferase activity 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0019198 transmembrane receptor protein phosphatase activity 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0032183 SUMO binding 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0045125 bioactive lipid receptor activity 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0045236 CXCR chemokine receptor binding 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0070402 NADPH binding 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0070492 oligosaccharide binding 5/3944 17/18639 0.294117647058824 1.38997434673667 0.282237101874444 0.573413840459843 GO:0004465 lipoprotein lipase activity 4/3944 13/18639 0.307692307692308 1.45412700889374 0.288970995883274 0.580961091723537 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/3944 13/18639 0.307692307692308 1.45412700889374 0.288970995883274 0.580961091723537 GO:0005172 vascular endothelial growth factor receptor binding 4/3944 13/18639 0.307692307692308 1.45412700889374 0.288970995883274 0.580961091723537 GO:0031994 insulin-like growth factor I binding 4/3944 13/18639 0.307692307692308 1.45412700889374 0.288970995883274 0.580961091723537 GO:0061459 L-arginine transmembrane transporter activity 4/3944 13/18639 0.307692307692308 1.45412700889374 0.288970995883274 0.580961091723537 GO:0071714 icosanoid transmembrane transporter activity 4/3944 13/18639 0.307692307692308 1.45412700889374 0.288970995883274 0.580961091723537 GO:0089720 caspase binding 4/3944 13/18639 0.307692307692308 1.45412700889374 0.288970995883274 0.580961091723537 GO:0008200 ion channel inhibitor activity 11/3944 43/18639 0.255813953488372 1.20895443181282 0.291413029293257 0.584997541666195 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 8/3944 30/18639 0.266666666666667 1.26024340770791 0.292442305518801 0.585319146409845 GO:0070566 adenylyltransferase activity 8/3944 30/18639 0.266666666666667 1.26024340770791 0.292442305518801 0.585319146409845 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 13/3944 52/18639 0.25 1.18147819472617 0.297162680042344 0.593884465900648 GO:0097110 scaffold protein binding 17/3944 70/18639 0.242857142857143 1.14772167487685 0.303040140908759 0.600187364146257 GO:0004435 phosphatidylinositol phospholipase C activity 7/3944 26/18639 0.269230769230769 1.27236113278203 0.303435482541649 0.600187364146257 GO:0005112 Notch binding 7/3944 26/18639 0.269230769230769 1.27236113278203 0.303435482541649 0.600187364146257 GO:0015216 purine nucleotide transmembrane transporter activity 7/3944 26/18639 0.269230769230769 1.27236113278203 0.303435482541649 0.600187364146257 GO:0030247 polysaccharide binding 7/3944 26/18639 0.269230769230769 1.27236113278203 0.303435482541649 0.600187364146257 GO:0051139 metal cation:proton antiporter activity 7/3944 26/18639 0.269230769230769 1.27236113278203 0.303435482541649 0.600187364146257 GO:0097602 cullin family protein binding 7/3944 26/18639 0.269230769230769 1.27236113278203 0.303435482541649 0.600187364146257 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 12/3944 48/18639 0.25 1.18147819472617 0.308174666360013 0.608667559511639 GO:1902936 phosphatidylinositol bisphosphate binding 26/3944 111/18639 0.234234234234234 1.10697056082452 0.313453079797241 0.618186381386359 GO:0015377 chloride:monoatomic cation symporter activity 6/3944 22/18639 0.272727272727273 1.28888530333764 0.315293396568134 0.620000299528871 GO:0031683 G-protein beta/gamma-subunit complex binding 6/3944 22/18639 0.272727272727273 1.28888530333764 0.315293396568134 0.620000299528871 GO:0015294 solute:monoatomic cation symporter activity 27/3944 116/18639 0.232758620689655 1.09999693991747 0.321756940229329 0.631788044444469 GO:0005246 calcium channel regulator activity 13/3944 53/18639 0.245283018867925 1.15918615331624 0.323266179626807 0.632906313891438 GO:0005544 calcium-dependent phospholipid binding 13/3944 53/18639 0.245283018867925 1.15918615331624 0.323266179626807 0.632906313891438 GO:0047499 calcium-independent phospholipase A2 activity 8/3944 31/18639 0.258064516129032 1.21959039455604 0.32698088747959 0.634189226170708 GO:0070273 phosphatidylinositol-4-phosphate binding 8/3944 31/18639 0.258064516129032 1.21959039455604 0.32698088747959 0.634189226170708 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 5/3944 18/18639 0.277777777777778 1.31275354969574 0.328158790379349 0.634189226170708 GO:0008525 phosphatidylcholine transporter activity 5/3944 18/18639 0.277777777777778 1.31275354969574 0.328158790379349 0.634189226170708 GO:0015172 acidic amino acid transmembrane transporter activity 5/3944 18/18639 0.277777777777778 1.31275354969574 0.328158790379349 0.634189226170708 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 5/3944 18/18639 0.277777777777778 1.31275354969574 0.328158790379349 0.634189226170708 GO:0035615 clathrin adaptor activity 5/3944 18/18639 0.277777777777778 1.31275354969574 0.328158790379349 0.634189226170708 GO:0098641 cadherin binding involved in cell-cell adhesion 5/3944 18/18639 0.277777777777778 1.31275354969574 0.328158790379349 0.634189226170708 GO:1990381 ubiquitin-specific protease binding 5/3944 18/18639 0.277777777777778 1.31275354969574 0.328158790379349 0.634189226170708 GO:0015144 carbohydrate transmembrane transporter activity 10/3944 40/18639 0.25 1.18147819472617 0.332823333979257 0.640447186957227 GO:0030331 nuclear estrogen receptor binding 10/3944 40/18639 0.25 1.18147819472617 0.332823333979257 0.640447186957227 GO:0050997 quaternary ammonium group binding 10/3944 40/18639 0.25 1.18147819472617 0.332823333979257 0.640447186957227 GO:0001222 transcription corepressor binding 12/3944 49/18639 0.244897959183673 1.1573663948338 0.335734537422121 0.645127563348925 GO:0061980 regulatory RNA binding 14/3944 58/18639 0.241379310344828 1.14073756732182 0.33697635478129 0.646591381610253 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 41/3944 181/18639 0.226519337016575 1.07051062947564 0.338448977156292 0.64849327486419 GO:0004364 glutathione transferase activity 7/3944 27/18639 0.259259259259259 1.22523664638269 0.341101743538553 0.650102503253372 GO:0004065 arylsulfatase activity 4/3944 14/18639 0.285714285714286 1.35026079397276 0.342184613813393 0.650102503253372 GO:0008559 ABC-type xenobiotic transporter activity 4/3944 14/18639 0.285714285714286 1.35026079397276 0.342184613813393 0.650102503253372 GO:0016530 metallochaperone activity 4/3944 14/18639 0.285714285714286 1.35026079397276 0.342184613813393 0.650102503253372 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/3944 14/18639 0.285714285714286 1.35026079397276 0.342184613813393 0.650102503253372 GO:1901474 azole transmembrane transporter activity 4/3944 14/18639 0.285714285714286 1.35026079397276 0.342184613813393 0.650102503253372 GO:0005262 calcium channel activity 30/3944 131/18639 0.229007633587786 1.08227010203924 0.344806418697995 0.654160909839717 GO:0004519 endonuclease activity 29/3944 127/18639 0.228346456692913 1.07914543770264 0.354749648627078 0.662252181577259 GO:0000295 adenine nucleotide transmembrane transporter activity 6/3944 23/18639 0.260869565217391 1.23284681188817 0.356839025169344 0.662252181577259 GO:0140103 catalytic activity, acting on a glycoprotein 6/3944 23/18639 0.260869565217391 1.23284681188817 0.356839025169344 0.662252181577259 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 20/3944 86/18639 0.232558139534884 1.0990494834662 0.356955427925471 0.662252181577259 GO:0001094 TFIID-class transcription factor complex binding 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0004955 prostaglandin receptor activity 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0008641 ubiquitin-like modifier activating enzyme activity 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0031996 thioesterase binding 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0042975 peroxisome proliferator activated receptor binding 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0043121 neurotrophin binding 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0070739 protein-glutamic acid ligase activity 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0070740 tubulin-glutamic acid ligase activity 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:1990763 arrestin family protein binding 3/3944 10/18639 0.3 1.4177738336714 0.357429351155655 0.662252181577259 GO:0008378 galactosyltransferase activity 8/3944 32/18639 0.25 1.18147819472617 0.362156735480427 0.670089454247438 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 14/3944 59/18639 0.23728813559322 1.12140303228246 0.362708885855089 0.670190492793971 GO:0048020 CCR chemokine receptor binding 12/3944 50/18639 0.24 1.13421906693712 0.363755625317975 0.670437653472881 GO:0140828 metal cation:monoatomic cation antiporter activity 10/3944 41/18639 0.24390243902439 1.15266165339138 0.363838102961155 0.670437653472881 GO:0004536 DNA nuclease activity 15/3944 64/18639 0.234375 1.10763580755578 0.374456466852112 0.679322111514473 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0005346 purine ribonucleotide transmembrane transporter activity 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0005520 insulin-like growth factor binding 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0008574 plus-end-directed microtubule motor activity 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0034987 immunoglobulin receptor binding 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0042800 histone H3K4 methyltransferase activity 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0043395 heparan sulfate proteoglycan binding 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0046527 glucosyltransferase activity 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0046624 sphingolipid transporter activity 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0050145 nucleoside monophosphate kinase activity 5/3944 19/18639 0.263157894736842 1.24366125760649 0.374711454235526 0.679322111514473 GO:0030276 clathrin binding 11/3944 46/18639 0.239130434782609 1.13010957756416 0.378785784888803 0.68576908808958 GO:0050698 proteoglycan sulfotransferase activity 7/3944 28/18639 0.25 1.18147819472617 0.379285798535068 0.68576908808958 GO:0042805 actinin binding 9/3944 37/18639 0.243243243243243 1.14954635162546 0.379884938994376 0.685931652580998 GO:0016887 ATP hydrolysis activity 91/3944 417/18639 0.218225419664269 1.0313142994732 0.387953844233116 0.699095804270705 GO:0001098 basal transcription machinery binding 14/3944 60/18639 0.233333333333333 1.10271298174442 0.388732559316079 0.699095804270705 GO:0001099 basal RNA polymerase II transcription machinery binding 14/3944 60/18639 0.233333333333333 1.10271298174442 0.388732559316079 0.699095804270705 GO:0005048 signal sequence binding 12/3944 51/18639 0.235294117647059 1.11197947738933 0.3920812469835 0.702044232097702 GO:0016830 carbon-carbon lyase activity 12/3944 51/18639 0.235294117647059 1.11197947738933 0.3920812469835 0.702044232097702 GO:0035198 miRNA binding 10/3944 42/18639 0.238095238095238 1.12521732831063 0.395170140455733 0.702044232097702 GO:0042056 chemoattractant activity 10/3944 42/18639 0.238095238095238 1.12521732831063 0.395170140455733 0.702044232097702 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 4/3944 15/18639 0.266666666666667 1.26024340770791 0.395583943698705 0.702044232097702 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 4/3944 15/18639 0.266666666666667 1.26024340770791 0.395583943698705 0.702044232097702 GO:0008242 omega peptidase activity 4/3944 15/18639 0.266666666666667 1.26024340770791 0.395583943698705 0.702044232097702 GO:0010181 FMN binding 4/3944 15/18639 0.266666666666667 1.26024340770791 0.395583943698705 0.702044232097702 GO:0042809 nuclear vitamin D receptor binding 4/3944 15/18639 0.266666666666667 1.26024340770791 0.395583943698705 0.702044232097702 GO:0048531 beta-1,3-galactosyltransferase activity 4/3944 15/18639 0.266666666666667 1.26024340770791 0.395583943698705 0.702044232097702 GO:0004806 triacylglycerol lipase activity 6/3944 24/18639 0.25 1.18147819472617 0.398695358257955 0.704780377392999 GO:0030552 cAMP binding 6/3944 24/18639 0.25 1.18147819472617 0.398695358257955 0.704780377392999 GO:0070840 dynein complex binding 6/3944 24/18639 0.25 1.18147819472617 0.398695358257955 0.704780377392999 GO:0030170 pyridoxal phosphate binding 13/3944 56/18639 0.232142857142857 1.09708689510287 0.404048417949251 0.713306971137145 GO:0004518 nuclease activity 46/3944 209/18639 0.220095693779904 1.04015305181634 0.408096766361158 0.719510921843561 GO:0004540 RNA nuclease activity 27/3944 121/18639 0.223140495867769 1.05454252091261 0.41276930800906 0.726455464701277 GO:0001851 complement component C3b binding 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0003953 NAD+ nucleosidase activity 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0004143 ATP-dependent diacylglycerol kinase activity 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0004954 prostanoid receptor activity 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0008199 ferric iron binding 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0019215 intermediate filament binding 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0050786 RAGE receptor binding 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0070697 activin receptor binding 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/3944 11/18639 0.272727272727273 1.28888530333764 0.421087639429661 0.726455464701277 GO:0001614 purinergic nucleotide receptor activity 5/3944 20/18639 0.25 1.18147819472617 0.421203947981958 0.726455464701277 GO:0016502 nucleotide receptor activity 5/3944 20/18639 0.25 1.18147819472617 0.421203947981958 0.726455464701277 GO:0016410 N-acyltransferase activity 21/3944 94/18639 0.223404255319149 1.05578902507445 0.429434278024169 0.739703289640096 GO:0004601 peroxidase activity 13/3944 57/18639 0.228070175438596 1.07783975659229 0.431346161510744 0.741101121881341 GO:0070279 vitamin B6 binding 13/3944 57/18639 0.228070175438596 1.07783975659229 0.431346161510744 0.741101121881341 GO:0008376 acetylgalactosaminyltransferase activity 8/3944 34/18639 0.235294117647059 1.11197947738933 0.433184275641403 0.742365418942709 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 8/3944 34/18639 0.235294117647059 1.11197947738933 0.433184275641403 0.742365418942709 GO:0016879 ligase activity, forming carbon-nitrogen bonds 11/3944 48/18639 0.229166666666667 1.08302167849899 0.438448137734442 0.749929276716261 GO:0003707 nuclear steroid receptor activity 6/3944 25/18639 0.24 1.13421906693712 0.440381631687129 0.749929276716261 GO:0005537 D-mannose binding 6/3944 25/18639 0.24 1.13421906693712 0.440381631687129 0.749929276716261 GO:0015296 monoatomic anion:monoatomic cation symporter activity 6/3944 25/18639 0.24 1.13421906693712 0.440381631687129 0.749929276716261 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 6/3944 25/18639 0.24 1.13421906693712 0.440381631687129 0.749929276716261 GO:0140034 methylation-dependent protein binding 17/3944 76/18639 0.223684210526316 1.05711206896552 0.442654208264283 0.75284749814645 GO:0016776 phosphotransferase activity, phosphate group as acceptor 9/3944 39/18639 0.230769230769231 1.09059525667031 0.446432954926677 0.755113949016782 GO:0004707 MAP kinase activity 4/3944 16/18639 0.25 1.18147819472617 0.448211988159879 0.755113949016782 GO:0004708 MAP kinase kinase activity 4/3944 16/18639 0.25 1.18147819472617 0.448211988159879 0.755113949016782 GO:0015385 sodium:proton antiporter activity 4/3944 16/18639 0.25 1.18147819472617 0.448211988159879 0.755113949016782 GO:0015562 efflux transmembrane transporter activity 4/3944 16/18639 0.25 1.18147819472617 0.448211988159879 0.755113949016782 GO:0030275 LRR domain binding 4/3944 16/18639 0.25 1.18147819472617 0.448211988159879 0.755113949016782 GO:0031435 mitogen-activated protein kinase kinase kinase binding 4/3944 16/18639 0.25 1.18147819472617 0.448211988159879 0.755113949016782 GO:0004864 protein phosphatase inhibitor activity 12/3944 53/18639 0.226415094339623 1.07001798767653 0.44903212558459 0.755113949016782 GO:0008146 sulfotransferase activity 12/3944 53/18639 0.226415094339623 1.07001798767653 0.44903212558459 0.755113949016782 GO:0035925 mRNA 3'-UTR AU-rich region binding 7/3944 30/18639 0.233333333333333 1.10271298174442 0.45569566383943 0.765364163580689 GO:0004866 endopeptidase inhibitor activity 35/3944 161/18639 0.217391304347826 1.02737234324014 0.459377102820771 0.770586497508815 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/3944 21/18639 0.238095238095238 1.12521732831063 0.467024736437139 0.778066412949183 GO:0001846 opsonin binding 5/3944 21/18639 0.238095238095238 1.12521732831063 0.467024736437139 0.778066412949183 GO:0015174 basic amino acid transmembrane transporter activity 5/3944 21/18639 0.238095238095238 1.12521732831063 0.467024736437139 0.778066412949183 GO:0140312 cargo adaptor activity 5/3944 21/18639 0.238095238095238 1.12521732831063 0.467024736437139 0.778066412949183 GO:0035254 glutamate receptor binding 11/3944 49/18639 0.224489795918367 1.06091919526431 0.468181022035377 0.778066412949183 GO:0004623 phospholipase A2 activity 8/3944 35/18639 0.228571428571429 1.08020863517821 0.468457209281208 0.778066412949183 GO:0034061 DNA polymerase activity 8/3944 35/18639 0.228571428571429 1.08020863517821 0.468457209281208 0.778066412949183 GO:0043015 gamma-tubulin binding 8/3944 35/18639 0.228571428571429 1.08020863517821 0.468457209281208 0.778066412949183 GO:0004529 DNA exonuclease activity 6/3944 26/18639 0.230769230769231 1.09059525667031 0.481465476430773 0.784825362996376 GO:0005227 calcium-activated cation channel activity 6/3944 26/18639 0.230769230769231 1.09059525667031 0.481465476430773 0.784825362996376 GO:0030507 spectrin binding 6/3944 26/18639 0.230769230769231 1.09059525667031 0.481465476430773 0.784825362996376 GO:0003995 acyl-CoA dehydrogenase activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0004000 adenosine deaminase activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0004300 enoyl-CoA hydratase activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0015132 prostaglandin transmembrane transporter activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0016273 arginine N-methyltransferase activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0016274 protein-arginine N-methyltransferase activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0016801 hydrolase activity, acting on ether bonds 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0016803 ether hydrolase activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0016840 carbon-nitrogen lyase activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0017166 vinculin binding 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0035197 siRNA binding 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/3944 12/18639 0.25 1.18147819472617 0.48243162625167 0.784825362996376 GO:0051539 4 iron, 4 sulfur cluster binding 10/3944 45/18639 0.222222222222222 1.05020283975659 0.489039402531477 0.794615289758624 GO:0005452 solute:inorganic anion antiporter activity 7/3944 31/18639 0.225806451612903 1.06714159523654 0.493237473611051 0.799507673831631 GO:0008327 methyl-CpG binding 7/3944 31/18639 0.225806451612903 1.06714159523654 0.493237473611051 0.799507673831631 GO:0009055 electron transfer activity 25/3944 116/18639 0.21551724137931 1.01851568510876 0.495449775234378 0.802128422164311 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/3944 17/18639 0.235294117647059 1.11197947738933 0.499281183940013 0.806392991327575 GO:1990226 histone methyltransferase binding 4/3944 17/18639 0.235294117647059 1.11197947738933 0.499281183940013 0.806392991327575 GO:0004869 cysteine-type endopeptidase inhibitor activity 8/3944 36/18639 0.222222222222222 1.05020283975659 0.503220122541036 0.811781443188952 GO:0035064 methylated histone binding 16/3944 74/18639 0.216216216216216 1.02181897922263 0.507052268683055 0.81698493530631 GO:0005200 structural constituent of cytoskeleton 24/3944 112/18639 0.214285714285714 1.01269559547957 0.509581953173345 0.820079917472516 GO:0030414 peptidase inhibitor activity 36/3944 169/18639 0.21301775147929 1.00670331384951 0.512491428300358 0.823777987972056 GO:0019838 growth factor binding 29/3944 136/18639 0.213235294117647 1.00773140138408 0.515323975143515 0.827343736017062 GO:0008320 protein transmembrane transporter activity 6/3944 27/18639 0.222222222222222 1.05020283975659 0.521569400114264 0.835379288886937 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 6/3944 27/18639 0.222222222222222 1.05020283975659 0.521569400114264 0.835379288886937 GO:0008237 metallopeptidase activity 39/3944 184/18639 0.21195652173913 1.00168803465914 0.524584458508421 0.83921052922903 GO:0141108 transporter regulator activity 36/3944 170/18639 0.211764705882353 1.0007815296504 0.528384452254678 0.84428690057776 GO:0046873 metal ion transmembrane transporter activity 95/3944 450/18639 0.211111111111111 0.997692697768763 0.529268083649334 0.844696811227077 GO:0047498 calcium-dependent phospholipase A2 activity 7/3944 32/18639 0.21875 1.0337934203854 0.529940080287626 0.844768388340157 GO:0019212 phosphatase inhibitor activity 12/3944 56/18639 0.214285714285714 1.01269559547957 0.533060108845288 0.848737549189837 GO:0005542 folic acid binding 3/3944 13/18639 0.230769230769231 1.09059525667031 0.540469815362189 0.852474053036146 GO:0008417 fucosyltransferase activity 3/3944 13/18639 0.230769230769231 1.09059525667031 0.540469815362189 0.852474053036146 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 3/3944 13/18639 0.230769230769231 1.09059525667031 0.540469815362189 0.852474053036146 GO:0019855 calcium channel inhibitor activity 3/3944 13/18639 0.230769230769231 1.09059525667031 0.540469815362189 0.852474053036146 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/3944 13/18639 0.230769230769231 1.09059525667031 0.540469815362189 0.852474053036146 GO:0046974 histone H3K9 methyltransferase activity 3/3944 13/18639 0.230769230769231 1.09059525667031 0.540469815362189 0.852474053036146 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 3/3944 13/18639 0.230769230769231 1.09059525667031 0.540469815362189 0.852474053036146 GO:0140333 glycerophospholipid flippase activity 3/3944 13/18639 0.230769230769231 1.09059525667031 0.540469815362189 0.852474053036146 GO:0004520 DNA endonuclease activity 9/3944 42/18639 0.214285714285714 1.01269559547957 0.543764418403331 0.856667452151213 GO:0008409 5'-3' exonuclease activity 4/3944 18/18639 0.222222222222222 1.05020283975659 0.548173296385917 0.86159793492629 GO:0070628 proteasome binding 4/3944 18/18639 0.222222222222222 1.05020283975659 0.548173296385917 0.86159793492629 GO:0017022 myosin binding 16/3944 76/18639 0.210526315789474 0.994929006085193 0.554485150077787 0.867735670364096 GO:0004022 alcohol dehydrogenase (NAD+) activity 5/3944 23/18639 0.217391304347826 1.02737234324014 0.554655094419812 0.867735670364096 GO:0005283 amino acid:sodium symporter activity 5/3944 23/18639 0.217391304347826 1.02737234324014 0.554655094419812 0.867735670364096 GO:0016849 phosphorus-oxygen lyase activity 5/3944 23/18639 0.217391304347826 1.02737234324014 0.554655094419812 0.867735670364096 GO:0005125 cytokine activity 49/3944 234/18639 0.209401709401709 0.98961421438602 0.559037900357034 0.871621019890257 GO:0045499 chemorepellent activity 6/3944 28/18639 0.214285714285714 1.01269559547957 0.560374018726772 0.871621019890257 GO:0051119 sugar transmembrane transporter activity 6/3944 28/18639 0.214285714285714 1.01269559547957 0.560374018726772 0.871621019890257 GO:0051393 alpha-actinin binding 6/3944 28/18639 0.214285714285714 1.01269559547957 0.560374018726772 0.871621019890257 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/3944 28/18639 0.214285714285714 1.01269559547957 0.560374018726772 0.871621019890257 GO:0003774 cytoskeletal motor activity 32/3944 153/18639 0.209150326797386 0.988426202123852 0.561741392007106 0.872740086543911 GO:0140597 protein carrier chaperone 39/3944 188/18639 0.207446808510638 0.980375523283415 0.584574561814962 0.907168127609164 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 12/3944 58/18639 0.206896551724138 0.977775057704414 0.586681726746592 0.907999562325319 GO:0005229 intracellularly calcium-gated chloride channel activity 4/3944 19/18639 0.210526315789474 0.994929006085193 0.594429787626021 0.907999562325319 GO:0022821 solute:potassium antiporter activity 4/3944 19/18639 0.210526315789474 0.994929006085193 0.594429787626021 0.907999562325319 GO:0030506 ankyrin binding 4/3944 19/18639 0.210526315789474 0.994929006085193 0.594429787626021 0.907999562325319 GO:0042834 peptidoglycan binding 4/3944 19/18639 0.210526315789474 0.994929006085193 0.594429787626021 0.907999562325319 GO:0141147 intracellularly calcium-gated channel activity 4/3944 19/18639 0.210526315789474 0.994929006085193 0.594429787626021 0.907999562325319 GO:0004705 JUN kinase activity 3/3944 14/18639 0.214285714285714 1.01269559547957 0.59454759760277 0.907999562325319 GO:0005347 ATP transmembrane transporter activity 3/3944 14/18639 0.214285714285714 1.01269559547957 0.59454759760277 0.907999562325319 GO:0008494 translation activator activity 3/3944 14/18639 0.214285714285714 1.01269559547957 0.59454759760277 0.907999562325319 GO:0015386 potassium:proton antiporter activity 3/3944 14/18639 0.214285714285714 1.01269559547957 0.59454759760277 0.907999562325319 GO:0019992 diacylglycerol binding 3/3944 14/18639 0.214285714285714 1.01269559547957 0.59454759760277 0.907999562325319 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/3944 14/18639 0.214285714285714 1.01269559547957 0.59454759760277 0.907999562325319 GO:0031404 chloride ion binding 3/3944 14/18639 0.214285714285714 1.01269559547957 0.59454759760277 0.907999562325319 GO:0042043 neurexin family protein binding 3/3944 14/18639 0.214285714285714 1.01269559547957 0.59454759760277 0.907999562325319 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 5/3944 24/18639 0.208333333333333 0.984565162271805 0.595697130251879 0.908724840825913 GO:0005416 amino acid:monoatomic cation symporter activity 6/3944 29/18639 0.206896551724138 0.977775057704414 0.597618576595161 0.909942267385634 GO:0008175 tRNA methyltransferase activity 7/3944 34/18639 0.205882352941176 0.972982042715666 0.599872853332178 0.909942267385634 GO:0016831 carboxy-lyase activity 7/3944 34/18639 0.205882352941176 0.972982042715666 0.599872853332178 0.909942267385634 GO:0030332 cyclin binding 7/3944 34/18639 0.205882352941176 0.972982042715666 0.599872853332178 0.909942267385634 GO:0051427 hormone receptor binding 7/3944 34/18639 0.205882352941176 0.972982042715666 0.599872853332178 0.909942267385634 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/3944 54/18639 0.203703703703704 0.962685936443543 0.609917449511924 0.924138137786908 GO:0020037 heme binding 29/3944 142/18639 0.204225352112676 0.965151201325601 0.618362103812478 0.935179791376064 GO:0016829 lyase activity 41/3944 200/18639 0.205 0.968812119675456 0.618593314117352 0.935179791376064 GO:0046906 tetrapyrrole binding 31/3944 152/18639 0.203947368421053 0.96383747464503 0.623427715937341 0.941431763865021 GO:0003727 single-stranded RNA binding 18/3944 89/18639 0.202247191011236 0.955802584497573 0.627087714536145 0.94589826593526 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 8/3944 40/18639 0.2 0.945182555780933 0.633020667850701 0.947309434537906 GO:0016769 transferase activity, transferring nitrogenous groups 6/3944 30/18639 0.2 0.945182555780933 0.633099304784093 0.947309434537906 GO:0022839 monoatomic ion-gated channel activity 6/3944 30/18639 0.2 0.945182555780933 0.633099304784093 0.947309434537906 GO:0001848 complement binding 5/3944 25/18639 0.2 0.945182555780933 0.634526004893067 0.947309434537906 GO:0005251 delayed rectifier potassium channel activity 5/3944 25/18639 0.2 0.945182555780933 0.634526004893067 0.947309434537906 GO:0008483 transaminase activity 5/3944 25/18639 0.2 0.945182555780933 0.634526004893067 0.947309434537906 GO:0015271 outward rectifier potassium channel activity 5/3944 25/18639 0.2 0.945182555780933 0.634526004893067 0.947309434537906 GO:0098632 cell-cell adhesion mediator activity 11/3944 55/18639 0.2 0.945182555780933 0.636043125262299 0.947309434537906 GO:0000339 RNA cap binding 4/3944 20/18639 0.2 0.945182555780933 0.637736247537037 0.947309434537906 GO:0001972 retinoic acid binding 4/3944 20/18639 0.2 0.945182555780933 0.637736247537037 0.947309434537906 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 4/3944 20/18639 0.2 0.945182555780933 0.637736247537037 0.947309434537906 GO:0031418 L-ascorbic acid binding 4/3944 20/18639 0.2 0.945182555780933 0.637736247537037 0.947309434537906 GO:0061608 nuclear import signal receptor activity 4/3944 20/18639 0.2 0.945182555780933 0.637736247537037 0.947309434537906 GO:0061775 cohesin loader activity 31/3944 153/18639 0.202614379084967 0.957537883307481 0.639102109722893 0.947309434537906 GO:0048306 calcium-dependent protein binding 16/3944 80/18639 0.2 0.945182555780933 0.643863009901116 0.947309434537906 GO:0000774 adenyl-nucleotide exchange factor activity 3/3944 15/18639 0.2 0.945182555780933 0.644288511078786 0.947309434537906 GO:0004953 icosanoid receptor activity 3/3944 15/18639 0.2 0.945182555780933 0.644288511078786 0.947309434537906 GO:0005523 tropomyosin binding 3/3944 15/18639 0.2 0.945182555780933 0.644288511078786 0.947309434537906 GO:0016846 carbon-sulfur lyase activity 3/3944 15/18639 0.2 0.945182555780933 0.644288511078786 0.947309434537906 GO:0033130 acetylcholine receptor binding 3/3944 15/18639 0.2 0.945182555780933 0.644288511078786 0.947309434537906 GO:0034483 heparan sulfate sulfotransferase activity 3/3944 15/18639 0.2 0.945182555780933 0.644288511078786 0.947309434537906 GO:0016247 channel regulator activity 34/3944 168/18639 0.202380952380952 0.956434729064039 0.64550252999342 0.947309434537906 GO:0005506 iron ion binding 31/3944 154/18639 0.201298701298701 0.951320104844446 0.654472436077285 0.947309434537906 GO:0004382 GDP phosphatase activity 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0005337 nucleoside transmembrane transporter activity 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0005528 FK506 binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0008190 eukaryotic initiation factor 4E binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0015203 polyamine transmembrane transporter activity 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0031419 cobalamin binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0031956 medium-chain fatty acid-CoA ligase activity 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0032052 bile acid binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0035256 G protein-coupled glutamate receptor binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0035374 chondroitin sulfate binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0043295 glutathione binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0070097 delta-catenin binding 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0141109 transporter activator activity 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/3944 10/18639 0.2 0.945182555780933 0.658264016872665 0.947309434537906 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 9/3944 46/18639 0.195652173913043 0.92463510891613 0.661507804964 0.9500218602628 GO:0016836 hydro-lyase activity 12/3944 61/18639 0.19672131147541 0.929687759784524 0.661559394897183 0.9500218602628 GO:0051536 iron-sulfur cluster binding 15/3944 76/18639 0.197368421052632 0.932745943204868 0.663745560623372 0.951479226748878 GO:0045505 dynein intermediate chain binding 7/3944 36/18639 0.194444444444444 0.918927484787018 0.663986988228616 0.951479226748878 GO:0016209 antioxidant activity 17/3944 86/18639 0.197674418604651 0.934192060946271 0.665803190869626 0.95306790446481 GO:0015145 monosaccharide transmembrane transporter activity 5/3944 26/18639 0.192307692307692 0.90882938055859 0.67096898786028 0.958688889883762 GO:0099106 ion channel regulator activity 32/3944 160/18639 0.2 0.945182555780933 0.671153395070815 0.958688889883762 GO:0015103 inorganic anion transmembrane transporter activity 33/3944 165/18639 0.2 0.945182555780933 0.672772438897385 0.959983554231756 GO:0035613 RNA stem-loop binding 4/3944 21/18639 0.19047619047619 0.900173862648508 0.677903661913484 0.966281727616362 GO:0042054 histone methyltransferase activity 13/3944 67/18639 0.194029850746269 0.916968151130756 0.684456008825384 0.973743853846467 GO:0051540 metal cluster binding 15/3944 77/18639 0.194805194805195 0.920632359526883 0.684584580246922 0.973743853846467 GO:0008296 3'-5'-DNA exonuclease activity 3/3944 16/18639 0.1875 0.886108646044625 0.689536939444689 0.976662731263928 GO:0015378 sodium:chloride symporter activity 3/3944 16/18639 0.1875 0.886108646044625 0.689536939444689 0.976662731263928 GO:0022841 potassium ion leak channel activity 3/3944 16/18639 0.1875 0.886108646044625 0.689536939444689 0.976662731263928 GO:0055102 lipase inhibitor activity 3/3944 16/18639 0.1875 0.886108646044625 0.689536939444689 0.976662731263928 GO:0043175 RNA polymerase core enzyme binding 8/3944 42/18639 0.19047619047619 0.900173862648508 0.690286744214915 0.976697735774675 GO:0030551 cyclic nucleotide binding 7/3944 37/18639 0.189189189189189 0.894091606819802 0.693560440476853 0.98030001397935 GO:0140674 ATP-dependent histone chaperone activity 30/3944 152/18639 0.197368421052632 0.932745943204868 0.697462595322495 0.984782092137737 GO:0008395 steroid hydroxylase activity 5/3944 27/18639 0.185185185185185 0.875169033130494 0.704923439620738 0.989335151214276 GO:0015252 proton channel activity 5/3944 27/18639 0.185185185185185 0.875169033130494 0.704923439620738 0.989335151214276 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0004016 adenylate cyclase activity 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0008172 S-methyltransferase activity 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0008271 secondary active sulfate transmembrane transporter activity 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0015217 ADP transmembrane transporter activity 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0032404 mismatch repair complex binding 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0043522 leucine zipper domain binding 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0050998 nitric-oxide synthase binding 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:1900750 oligopeptide binding 2/3944 11/18639 0.181818181818182 0.859256868891757 0.710969878526666 0.989335151214276 GO:0140658 ATP-dependent chromatin remodeler activity 31/3944 158/18639 0.19620253164557 0.927236051557244 0.712576065378526 0.990546914411635 GO:0070034 telomerase RNA binding 4/3944 22/18639 0.181818181818182 0.859256868891757 0.714848564315482 0.991659130929922 GO:0140517 protein-RNA adaptor activity 4/3944 22/18639 0.181818181818182 0.859256868891757 0.714848564315482 0.991659130929922 GO:0000146 microfilament motor activity 7/3944 38/18639 0.184210526315789 0.870562880324544 0.721387318365728 0.999700326994481 GO:0016835 carbon-oxygen lyase activity 15/3944 79/18639 0.189873417721519 0.89732521118443 0.723954225390676 1 GO:0140713 histone chaperone activity 32/3944 164/18639 0.195121951219512 0.922129322713105 0.726865164543857 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 3/3944 17/18639 0.176470588235294 0.833984608042 0.730306029909976 1 GO:0017110 nucleoside diphosphate phosphatase activity 3/3944 17/18639 0.176470588235294 0.833984608042 0.730306029909976 1 GO:0070888 E-box binding 11/3944 59/18639 0.186440677966102 0.881102382507649 0.730478867826869 1 GO:0051537 2 iron, 2 sulfur cluster binding 5/3944 28/18639 0.178571428571429 0.843912996232976 0.7363472267716 1 GO:0019842 vitamin binding 29/3944 150/18639 0.193333333333333 0.913676470588235 0.738601759727954 1 GO:0016782 transferase activity, transferring sulphur-containing groups 13/3944 70/18639 0.185714285714286 0.877669516082295 0.746015745061495 1 GO:0000510 H3-H4 histone complex chaperone activity 29/3944 151/18639 0.19205298013245 0.907625633034671 0.751854120694538 1 GO:0140584 chromatin extrusion motor activity 29/3944 151/18639 0.19205298013245 0.907625633034671 0.751854120694538 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 29/3944 151/18639 0.19205298013245 0.907625633034671 0.751854120694538 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 29/3944 151/18639 0.19205298013245 0.907625633034671 0.751854120694538 1 GO:0000340 RNA 7-methylguanosine cap binding 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0004032 aldose reductase (NADPH) activity 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0004859 phospholipase inhibitor activity 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0005165 neurotrophin receptor binding 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0005247 voltage-gated chloride channel activity 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0005527 macrolide binding 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0015166 polyol transmembrane transporter activity 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0042301 phosphate ion binding 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0045295 gamma-catenin binding 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0140900 chloride:bicarbonate antiporter activity 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/3944 12/18639 0.166666666666667 0.787652129817444 0.756677528981665 1 GO:0015616 DNA translocase activity 29/3944 152/18639 0.190789473684211 0.901654411764706 0.764678138871687 1 GO:0003746 translation elongation factor activity 3/3944 18/18639 0.166666666666667 0.787652129817444 0.766732576614788 1 GO:0015373 monoatomic anion:sodium symporter activity 3/3944 18/18639 0.166666666666667 0.787652129817444 0.766732576614788 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 3/3944 18/18639 0.166666666666667 0.787652129817444 0.766732576614788 1 GO:0070064 proline-rich region binding 3/3944 18/18639 0.166666666666667 0.787652129817444 0.766732576614788 1 GO:0099602 neurotransmitter receptor regulator activity 3/3944 18/18639 0.166666666666667 0.787652129817444 0.766732576614788 1 GO:0015036 disulfide oxidoreductase activity 7/3944 40/18639 0.175 0.827034736308316 0.771707991884954 1 GO:0071855 neuropeptide receptor binding 7/3944 40/18639 0.175 0.827034736308316 0.771707991884954 1 GO:0001664 G protein-coupled receptor binding 58/3944 297/18639 0.195286195286195 0.922905525846702 0.776340434665857 1 GO:0015149 hexose transmembrane transporter activity 4/3944 24/18639 0.166666666666667 0.787652129817444 0.779148780365003 1 GO:0055056 D-glucose transmembrane transporter activity 4/3944 24/18639 0.166666666666667 0.787652129817444 0.779148780365003 1 GO:0005343 organic acid:sodium symporter activity 6/3944 35/18639 0.171428571428571 0.810156476383657 0.780407111001162 1 GO:0008170 N-methyltransferase activity 18/3944 98/18639 0.183673469387755 0.868024796125347 0.786425609170755 1 GO:0140104 molecular carrier activity 48/3944 249/18639 0.192771084337349 0.911019330873189 0.78970058127164 1 GO:0033612 receptor serine/threonine kinase binding 5/3944 30/18639 0.166666666666667 0.787652129817444 0.791678973713211 1 GO:0017080 sodium channel regulator activity 7/3944 41/18639 0.170731707317073 0.806863157373967 0.794217163495906 1 GO:0008253 5'-nucleotidase activity 2/3944 13/18639 0.153846153846154 0.727063504446872 0.795988022367024 1 GO:0019104 DNA N-glycosylase activity 2/3944 13/18639 0.153846153846154 0.727063504446872 0.795988022367024 1 GO:0031432 titin binding 2/3944 13/18639 0.153846153846154 0.727063504446872 0.795988022367024 1 GO:0039706 co-receptor binding 2/3944 13/18639 0.153846153846154 0.727063504446872 0.795988022367024 1 GO:0070700 BMP receptor binding 2/3944 13/18639 0.153846153846154 0.727063504446872 0.795988022367024 1 GO:0097157 pre-mRNA intronic binding 2/3944 13/18639 0.153846153846154 0.727063504446872 0.795988022367024 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/3944 13/18639 0.153846153846154 0.727063504446872 0.795988022367024 1 GO:0003756 protein disulfide isomerase activity 3/3944 19/18639 0.157894736842105 0.746196754563895 0.799039349550181 1 GO:0008381 mechanosensitive monoatomic ion channel activity 3/3944 19/18639 0.157894736842105 0.746196754563895 0.799039349550181 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/3944 19/18639 0.157894736842105 0.746196754563895 0.799039349550181 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/3944 19/18639 0.157894736842105 0.746196754563895 0.799039349550181 1 GO:0022840 leak channel activity 3/3944 19/18639 0.157894736842105 0.746196754563895 0.799039349550181 1 GO:0022842 narrow pore channel activity 3/3944 19/18639 0.157894736842105 0.746196754563895 0.799039349550181 1 GO:0000993 RNA polymerase II complex binding 6/3944 36/18639 0.166666666666667 0.787652129817444 0.803691135555672 1 GO:0061749 forked DNA-dependent helicase activity 8/3944 47/18639 0.170212765957447 0.804410685771007 0.806846120146289 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 8/3944 47/18639 0.170212765957447 0.804410685771007 0.806846120146289 1 GO:0003684 damaged DNA binding 13/3944 74/18639 0.175675675675676 0.830227920618387 0.814830541917869 1 GO:0070325 lipoprotein particle receptor binding 5/3944 31/18639 0.161290322580645 0.762243996597527 0.815719902453132 1 GO:0016279 protein-lysine N-methyltransferase activity 12/3944 69/18639 0.173913043478261 0.821897874592116 0.818940030404004 1 GO:0051082 unfolded protein binding 22/3944 121/18639 0.181818181818182 0.859256868891757 0.819427476909437 1 GO:0009378 four-way junction helicase activity 8/3944 48/18639 0.166666666666667 0.787652129817444 0.825584533487625 1 GO:0036121 double-stranded DNA helicase activity 8/3944 48/18639 0.166666666666667 0.787652129817444 0.825584533487625 1 GO:0043138 3'-5' DNA helicase activity 8/3944 48/18639 0.166666666666667 0.787652129817444 0.825584533487625 1 GO:0005313 L-glutamate transmembrane transporter activity 2/3944 14/18639 0.142857142857143 0.675130396986381 0.8295614264944 1 GO:0008174 mRNA methyltransferase activity 2/3944 14/18639 0.142857142857143 0.675130396986381 0.8295614264944 1 GO:0015926 glucosidase activity 2/3944 14/18639 0.142857142857143 0.675130396986381 0.8295614264944 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/3944 14/18639 0.142857142857143 0.675130396986381 0.8295614264944 1 GO:0032036 myosin heavy chain binding 2/3944 14/18639 0.142857142857143 0.675130396986381 0.8295614264944 1 GO:0098847 sequence-specific single stranded DNA binding 2/3944 14/18639 0.142857142857143 0.675130396986381 0.8295614264944 1 GO:0044183 protein folding chaperone 13/3944 75/18639 0.173333333333333 0.819158215010142 0.829672730527553 1 GO:0050750 low-density lipoprotein particle receptor binding 4/3944 26/18639 0.153846153846154 0.727063504446872 0.831373609844393 1 GO:0016278 lysine N-methyltransferase activity 12/3944 70/18639 0.171428571428571 0.810156476383657 0.834027813578316 1 GO:0005245 voltage-gated calcium channel activity 7/3944 43/18639 0.162790697674419 0.769334638426341 0.834119842549565 1 GO:0043022 ribosome binding 20/3944 112/18639 0.178571428571429 0.843912996232976 0.834923762432167 1 GO:0015106 bicarbonate transmembrane transporter activity 5/3944 32/18639 0.15625 0.738423871703854 0.83747945607854 1 GO:0031369 translation initiation factor binding 5/3944 32/18639 0.15625 0.738423871703854 0.83747945607854 1 GO:0140142 nucleocytoplasmic carrier activity 5/3944 32/18639 0.15625 0.738423871703854 0.83747945607854 1 GO:0005501 retinoid binding 6/3944 38/18639 0.157894736842105 0.746196754563895 0.844435398131579 1 GO:0019840 isoprenoid binding 6/3944 38/18639 0.157894736842105 0.746196754563895 0.844435398131579 1 GO:0140097 catalytic activity, acting on DNA 64/3944 336/18639 0.19047619047619 0.900173862648508 0.847296089766963 1 GO:0003689 DNA clamp loader activity 29/3944 160/18639 0.18125 0.856571691176471 0.851601388121024 1 GO:0015079 potassium ion transmembrane transporter activity 29/3944 160/18639 0.18125 0.856571691176471 0.851601388121024 1 GO:0019205 nucleobase-containing compound kinase activity 7/3944 44/18639 0.159090909090909 0.751849760280288 0.851632904450383 1 GO:0005248 voltage-gated sodium channel activity 3/3944 21/18639 0.142857142857143 0.675130396986381 0.852438093002141 1 GO:0010314 phosphatidylinositol-5-phosphate binding 3/3944 21/18639 0.142857142857143 0.675130396986381 0.852438093002141 1 GO:0061891 calcium ion sensor activity 3/3944 21/18639 0.142857142857143 0.675130396986381 0.852438093002141 1 GO:1904047 S-adenosyl-L-methionine binding 3/3944 21/18639 0.142857142857143 0.675130396986381 0.852438093002141 1 GO:0004386 helicase activity 28/3944 155/18639 0.180645161290323 0.85371327618923 0.852831286140154 1 GO:0008266 poly(U) RNA binding 4/3944 27/18639 0.148148148148148 0.700135226504395 0.853364943796333 1 GO:0003724 RNA helicase activity 13/3944 77/18639 0.168831168831169 0.797881378256632 0.856637223278051 1 GO:0004129 cytochrome-c oxidase activity 2/3944 15/18639 0.133333333333333 0.630121703853955 0.858064951942956 1 GO:0008252 nucleotidase activity 2/3944 15/18639 0.133333333333333 0.630121703853955 0.858064951942956 1 GO:0015116 sulfate transmembrane transporter activity 2/3944 15/18639 0.133333333333333 0.630121703853955 0.858064951942956 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/3944 15/18639 0.133333333333333 0.630121703853955 0.858064951942956 1 GO:0031005 filamin binding 2/3944 15/18639 0.133333333333333 0.630121703853955 0.858064951942956 1 GO:0031386 protein tag activity 2/3944 15/18639 0.133333333333333 0.630121703853955 0.858064951942956 1 GO:0140161 monocarboxylate:sodium symporter activity 2/3944 15/18639 0.133333333333333 0.630121703853955 0.858064951942956 1 GO:0141047 molecular tag activity 2/3944 15/18639 0.133333333333333 0.630121703853955 0.858064951942956 1 GO:0043021 ribonucleoprotein complex binding 32/3944 177/18639 0.180790960451977 0.854402310310448 0.865477530434338 1 GO:0008173 RNA methyltransferase activity 11/3944 67/18639 0.164179104477612 0.775896127879871 0.866532108687289 1 GO:0016874 ligase activity 30/3944 167/18639 0.179640718562874 0.848966367467904 0.867782302053679 1 GO:0042562 hormone binding 16/3944 94/18639 0.170212765957447 0.804410685771007 0.86838114514235 1 GO:0019199 transmembrane receptor protein kinase activity 13/3944 78/18639 0.166666666666667 0.787652129817444 0.868810184248064 1 GO:0004222 metalloendopeptidase activity 19/3944 110/18639 0.172727272727273 0.816294025447169 0.869745638518046 1 GO:0005272 sodium channel activity 8/3944 51/18639 0.156862745098039 0.741319651592889 0.873358327517738 1 GO:0140784 metal ion sensor activity 3/3944 22/18639 0.136363636363636 0.644442651668818 0.874162755426351 1 GO:0140662 ATP-dependent protein folding chaperone 6/3944 40/18639 0.15 0.7088869168357 0.878017814838764 1 GO:0003777 microtubule motor activity 11/3944 68/18639 0.161764705882353 0.764485890705166 0.87882147852129 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 11/3944 68/18639 0.161764705882353 0.764485890705166 0.87882147852129 1 GO:0008276 protein methyltransferase activity 16/3944 95/18639 0.168421052631579 0.795943204868154 0.878834162585418 1 GO:0008186 ATP-dependent activity, acting on RNA 13/3944 79/18639 0.164556962025316 0.777681849693173 0.880149578417102 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/3944 16/18639 0.125 0.590739097363083 0.882140382299851 1 GO:0019841 retinol binding 2/3944 16/18639 0.125 0.590739097363083 0.882140382299851 1 GO:0004497 monooxygenase activity 18/3944 106/18639 0.169811320754717 0.802513490757396 0.882230292348913 1 GO:0015081 sodium ion transmembrane transporter activity 29/3944 164/18639 0.176829268292683 0.835679698708752 0.884916694090517 1 GO:0008509 monoatomic anion transmembrane transporter activity 26/3944 149/18639 0.174496644295302 0.82465592115115 0.88964009270756 1 GO:0003785 actin monomer binding 4/3944 29/18639 0.137931034482759 0.651850038469609 0.890086915472524 1 GO:0004181 metallocarboxypeptidase activity 4/3944 29/18639 0.137931034482759 0.651850038469609 0.890086915472524 1 GO:0106222 lncRNA binding 4/3944 29/18639 0.137931034482759 0.651850038469609 0.890086915472524 1 GO:0017134 fibroblast growth factor binding 3/3944 23/18639 0.130434782608696 0.616423405944087 0.893001142938381 1 GO:0004549 tRNA-specific ribonuclease activity 2/3944 17/18639 0.117647058823529 0.555989738694667 0.902384962618501 1 GO:0004550 nucleoside diphosphate kinase activity 2/3944 17/18639 0.117647058823529 0.555989738694667 0.902384962618501 1 GO:0008569 minus-end-directed microtubule motor activity 2/3944 17/18639 0.117647058823529 0.555989738694667 0.902384962618501 1 GO:0030548 acetylcholine receptor regulator activity 2/3944 17/18639 0.117647058823529 0.555989738694667 0.902384962618501 1 GO:0031489 myosin V binding 2/3944 17/18639 0.117647058823529 0.555989738694667 0.902384962618501 1 GO:0015459 potassium channel regulator activity 9/3944 59/18639 0.152542372881356 0.720901949324441 0.902547516421541 1 GO:0005253 monoatomic anion channel activity 17/3944 103/18639 0.16504854368932 0.780005021760964 0.902965467279248 1 GO:1901681 sulfur compound binding 50/3944 275/18639 0.181818181818182 0.859256868891757 0.903705732577225 1 GO:0017171 serine hydrolase activity 35/3944 198/18639 0.176767676767677 0.835388622533653 0.90432008809642 1 GO:0098631 cell adhesion mediator activity 12/3944 76/18639 0.157894736842105 0.746196754563895 0.905147094329925 1 GO:0008187 poly-pyrimidine tract binding 4/3944 30/18639 0.133333333333333 0.630121703853955 0.905226598820111 1 GO:0048019 receptor antagonist activity 4/3944 30/18639 0.133333333333333 0.630121703853955 0.905226598820111 1 GO:0000182 rDNA binding 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0003796 lysozyme activity 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0008401 retinoic acid 4-hydroxylase activity 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0008519 ammonium channel activity 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0015187 glycine transmembrane transporter activity 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0015643 toxic substance binding 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0016427 tRNA (cytidine) methyltransferase activity 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0016868 intramolecular phosphotransferase activity 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0019911 structural constituent of myelin sheath 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0050815 phosphoserine residue binding 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0051880 G-quadruplex DNA binding 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0097177 mitochondrial ribosome binding 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0098505 G-rich strand telomeric DNA binding 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0140940 histone H2A methyltransferase activity 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:1990259 histone H2AQ104 methyltransferase activity 1/3944 10/18639 0.1 0.472591277890467 0.907276823555998 1 GO:0008083 growth factor activity 28/3944 162/18639 0.172839506172839 0.816824430921794 0.907392042187415 1 GO:0017069 snRNA binding 8/3944 54/18639 0.148148148148148 0.700135226504395 0.909824913613374 1 GO:0008236 serine-type peptidase activity 34/3944 194/18639 0.175257731958763 0.828252755065766 0.911329364125332 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 9/3944 60/18639 0.15 0.7088869168357 0.912761069355534 1 GO:0015108 chloride transmembrane transporter activity 20/3944 121/18639 0.165289256198347 0.781142608083416 0.916895410430919 1 GO:0005184 neuropeptide hormone activity 4/3944 31/18639 0.129032258064516 0.609795197278021 0.918486850133737 1 GO:0008308 voltage-gated monoatomic anion channel activity 2/3944 18/18639 0.111111111111111 0.525101419878296 0.919341510868965 1 GO:0015280 ligand-gated sodium channel activity 2/3944 18/18639 0.111111111111111 0.525101419878296 0.919341510868965 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/3944 18/18639 0.111111111111111 0.525101419878296 0.919341510868965 1 GO:0017128 phospholipid scramblase activity 2/3944 18/18639 0.111111111111111 0.525101419878296 0.919341510868965 1 GO:0031690 adrenergic receptor binding 2/3944 18/18639 0.111111111111111 0.525101419878296 0.919341510868965 1 GO:1901611 phosphatidylglycerol binding 2/3944 18/18639 0.111111111111111 0.525101419878296 0.919341510868965 1 GO:0017056 structural constituent of nuclear pore 3/3944 25/18639 0.12 0.56710953346856 0.923252555772716 1 GO:0004867 serine-type endopeptidase inhibitor activity 15/3944 95/18639 0.157894736842105 0.746196754563895 0.925010746258263 1 GO:0008013 beta-catenin binding 17/3944 106/18639 0.160377358490566 0.757929407937541 0.925253469877006 1 GO:0004527 exonuclease activity 13/3944 84/18639 0.154761904761905 0.731391263401913 0.92554153636505 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0008046 axon guidance receptor activity 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0008503 benzodiazepine receptor activity 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0010854 adenylate cyclase regulator activity 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0016594 glycine binding 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0019206 nucleoside kinase activity 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0031731 CCR6 chemokine receptor binding 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0034056 estrogen response element binding 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0045294 alpha-catenin binding 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0048407 platelet-derived growth factor binding 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0070990 snRNP binding 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/3944 11/18639 0.0909090909090909 0.429628434445879 0.926907518058931 1 GO:0030547 signaling receptor inhibitor activity 6/3944 44/18639 0.136363636363636 0.644442651668818 0.927112604933239 1 GO:0042162 telomeric DNA binding 5/3944 38/18639 0.131578947368421 0.621830628803245 0.927716987533905 1 GO:0160041 neuropeptide activity 4/3944 32/18639 0.125 0.590739097363083 0.930059334998765 1 GO:0008301 DNA binding, bending 2/3944 19/18639 0.105263157894737 0.497464503042596 0.933494706318234 1 GO:0016918 retinal binding 2/3944 19/18639 0.105263157894737 0.497464503042596 0.933494706318234 1 GO:0042577 lipid phosphatase activity 2/3944 19/18639 0.105263157894737 0.497464503042596 0.933494706318234 1 GO:0016597 amino acid binding 7/3944 51/18639 0.137254901960784 0.648654695143778 0.936239107481714 1 GO:0000049 tRNA binding 12/3944 80/18639 0.15 0.7088869168357 0.936812541900079 1 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0003720 telomerase activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0004526 ribonuclease P activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0005049 nuclear export signal receptor activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0005436 sodium:phosphate symporter activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0008179 adenylate cyclase binding 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0008504 monoamine transmembrane transporter activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0010853 cyclase activator activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0031543 peptidyl-proline dioxygenase activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0036009 protein-glutamine N-methyltransferase activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0043047 single-stranded telomeric DNA binding 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0070679 inositol 1,4,5 trisphosphate binding 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0097371 MDM2/MDM4 family protein binding 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:1990817 poly(A) RNA polymerase activity 1/3944 12/18639 0.0833333333333333 0.393826064908722 0.94238297161141 1 GO:0003823 antigen binding 29/3944 174/18639 0.166666666666667 0.787652129817444 0.942927013191832 1 GO:0008408 3'-5' exonuclease activity 8/3944 58/18639 0.137931034482759 0.651850038469609 0.94422347794659 1 GO:0017116 single-stranded DNA helicase activity 8/3944 58/18639 0.137931034482759 0.651850038469609 0.94422347794659 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 6/3944 46/18639 0.130434782608696 0.616423405944087 0.944382004350465 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/3944 20/18639 0.1 0.472591277890467 0.945271384481747 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/3944 20/18639 0.1 0.472591277890467 0.945271384481747 1 GO:0010851 cyclase regulator activity 2/3944 20/18639 0.1 0.472591277890467 0.945271384481747 1 GO:0043024 ribosomal small subunit binding 2/3944 20/18639 0.1 0.472591277890467 0.945271384481747 1 GO:0004532 RNA exonuclease activity 5/3944 40/18639 0.125 0.590739097363083 0.945849751051398 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 4/3944 34/18639 0.117647058823529 0.555989738694667 0.948852625698067 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 7/3944 53/18639 0.132075471698113 0.624177159477975 0.950818108217877 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/3944 41/18639 0.121951219512195 0.576330826695691 0.953275599699752 1 GO:0005254 chloride channel activity 12/3944 83/18639 0.144578313253012 0.683264498154891 0.954148240185908 1 GO:0008135 translation factor activity, RNA binding 12/3944 83/18639 0.144578313253012 0.683264498154891 0.954148240185908 1 GO:0005242 inward rectifier potassium channel activity 3/3944 28/18639 0.107142857142857 0.506347797739786 0.954183085572562 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/3944 13/18639 0.0769230769230769 0.363531752223436 0.954582550715109 1 GO:0003964 RNA-directed DNA polymerase activity 1/3944 13/18639 0.0769230769230769 0.363531752223436 0.954582550715109 1 GO:0004535 poly(A)-specific ribonuclease activity 1/3944 13/18639 0.0769230769230769 0.363531752223436 0.954582550715109 1 GO:0009982 pseudouridine synthase activity 1/3944 13/18639 0.0769230769230769 0.363531752223436 0.954582550715109 1 GO:0045159 myosin II binding 1/3944 13/18639 0.0769230769230769 0.363531752223436 0.954582550715109 1 GO:0046975 histone H3K36 methyltransferase activity 1/3944 13/18639 0.0769230769230769 0.363531752223436 0.954582550715109 1 GO:1901338 catecholamine binding 1/3944 13/18639 0.0769230769230769 0.363531752223436 0.954582550715109 1 GO:0009975 cyclase activity 2/3944 21/18639 0.0952380952380952 0.450086931324254 0.955043309900652 1 GO:0015125 bile acid transmembrane transporter activity 2/3944 21/18639 0.0952380952380952 0.450086931324254 0.955043309900652 1 GO:0036122 BMP binding 2/3944 21/18639 0.0952380952380952 0.450086931324254 0.955043309900652 1 GO:0051428 peptide hormone receptor binding 2/3944 21/18639 0.0952380952380952 0.450086931324254 0.955043309900652 1 GO:0008094 ATP-dependent activity, acting on DNA 35/3944 210/18639 0.166666666666667 0.787652129817444 0.957477949517337 1 GO:0180051 translation factor activity 12/3944 84/18639 0.142857142857143 0.675130396986381 0.958916024156052 1 GO:0008307 structural constituent of muscle 5/3944 42/18639 0.119047619047619 0.562608664155317 0.959761441142721 1 GO:0005267 potassium channel activity 19/3944 124/18639 0.153225806451613 0.72413179676765 0.960397525823057 1 GO:0046982 protein heterodimerization activity 65/3944 369/18639 0.176151761517615 0.832477860782665 0.962083426251488 1 GO:0015370 solute:sodium symporter activity 11/3944 79/18639 0.139240506329114 0.658038488201915 0.962543378064438 1 GO:0008649 rRNA methyltransferase activity 2/3944 22/18639 0.0909090909090909 0.429628434445879 0.963131365348083 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/3944 22/18639 0.0909090909090909 0.429628434445879 0.963131365348083 1 GO:0034062 5'-3' RNA polymerase activity 2/3944 22/18639 0.0909090909090909 0.429628434445879 0.963131365348083 1 GO:0097747 RNA polymerase activity 2/3944 22/18639 0.0909090909090909 0.429628434445879 0.963131365348083 1 GO:0008195 phosphatidate phosphatase activity 1/3944 14/18639 0.0714285714285714 0.33756519849319 0.964199560270548 1 GO:0008331 high voltage-gated calcium channel activity 1/3944 14/18639 0.0714285714285714 0.33756519849319 0.964199560270548 1 GO:0008392 arachidonate epoxygenase activity 1/3944 14/18639 0.0714285714285714 0.33756519849319 0.964199560270548 1 GO:0030983 mismatched DNA binding 1/3944 14/18639 0.0714285714285714 0.33756519849319 0.964199560270548 1 GO:0042813 Wnt receptor activity 1/3944 14/18639 0.0714285714285714 0.33756519849319 0.964199560270548 1 GO:0043176 amine binding 1/3944 14/18639 0.0714285714285714 0.33756519849319 0.964199560270548 1 GO:0061783 peptidoglycan muralytic activity 1/3944 14/18639 0.0714285714285714 0.33756519849319 0.964199560270548 1 GO:0070742 C2H2 zinc finger domain binding 1/3944 14/18639 0.0714285714285714 0.33756519849319 0.964199560270548 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/3944 43/18639 0.116279069767442 0.549524741733101 0.965411641489953 1 GO:0031491 nucleosome binding 10/3944 74/18639 0.135135135135135 0.638636862014144 0.966318424784598 1 GO:0098918 structural constituent of synapse 3/3944 30/18639 0.1 0.472591277890467 0.967840152916857 1 GO:0022829 wide pore channel activity 4/3944 37/18639 0.108108108108108 0.510909489611315 0.968495596397681 1 GO:0005212 structural constituent of eye lens 2/3944 23/18639 0.0869565217391304 0.410948937296058 0.969810434149007 1 GO:0008171 O-methyltransferase activity 2/3944 23/18639 0.0869565217391304 0.410948937296058 0.969810434149007 1 GO:0031681 G-protein beta-subunit binding 2/3944 23/18639 0.0869565217391304 0.410948937296058 0.969810434149007 1 GO:0099186 structural constituent of postsynapse 2/3944 23/18639 0.0869565217391304 0.410948937296058 0.969810434149007 1 GO:0140102 catalytic activity, acting on a rRNA 2/3944 23/18639 0.0869565217391304 0.410948937296058 0.969810434149007 1 GO:0008168 methyltransferase activity 33/3944 204/18639 0.161764705882353 0.764485890705166 0.970167546927265 1 GO:0003954 NADH dehydrogenase activity 5/3944 44/18639 0.113636363636364 0.537035543057348 0.970321774381839 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/3944 44/18639 0.113636363636364 0.537035543057348 0.970321774381839 1 GO:0015250 water channel activity 1/3944 15/18639 0.0666666666666667 0.315060851926978 0.971780603722519 1 GO:0030553 cGMP binding 1/3944 15/18639 0.0666666666666667 0.315060851926978 0.971780603722519 1 GO:0045504 dynein heavy chain binding 1/3944 15/18639 0.0666666666666667 0.315060851926978 0.971780603722519 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 26/3944 167/18639 0.155688622754491 0.735770851805517 0.972911032572609 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/3944 31/18639 0.0967741935483871 0.457346397958516 0.973128006786476 1 GO:0017147 Wnt-protein binding 3/3944 31/18639 0.0967741935483871 0.457346397958516 0.973128006786476 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 4/3944 38/18639 0.105263157894737 0.497464503042596 0.973293079793419 1 GO:0005540 hyaluronic acid binding 2/3944 24/18639 0.0833333333333333 0.393826064908722 0.975314494874994 1 GO:0140299 molecular sensor activity 9/3944 71/18639 0.126760563380282 0.599059366340028 0.976959742423616 1 GO:0070717 poly-purine tract binding 3/3944 32/18639 0.09375 0.443054323022312 0.977583386626585 1 GO:0008391 arachidonate monooxygenase activity 1/3944 16/18639 0.0625 0.295369548681542 0.97775661848403 1 GO:0017070 U6 snRNA binding 1/3944 16/18639 0.0625 0.295369548681542 0.97775661848403 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/3944 16/18639 0.0625 0.295369548681542 0.97775661848403 1 GO:0043023 ribosomal large subunit binding 1/3944 16/18639 0.0625 0.295369548681542 0.97775661848403 1 GO:0097027 ubiquitin-protein transferase activator activity 1/3944 16/18639 0.0625 0.295369548681542 0.97775661848403 1 GO:0036002 pre-mRNA binding 7/3944 59/18639 0.11864406779661 0.560701516141232 0.978350674812347 1 GO:0099094 ligand-gated monoatomic cation channel activity 20/3944 136/18639 0.147058823529412 0.694987173368333 0.978485511485751 1 GO:0017046 peptide hormone binding 6/3944 53/18639 0.113207547169811 0.535008993838264 0.979633343321747 1 GO:0005539 glycosaminoglycan binding 39/3944 242/18639 0.161157024793388 0.76161404288133 0.980557967514486 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 7/3944 60/18639 0.116666666666667 0.551356490872211 0.981222479736759 1 GO:0140098 catalytic activity, acting on RNA 66/3944 387/18639 0.170542635658915 0.805969621208548 0.982287347125707 1 GO:0009881 photoreceptor activity 1/3944 17/18639 0.0588235294117647 0.277994869347333 0.982467346975626 1 GO:0016018 cyclosporin A binding 1/3944 17/18639 0.0588235294117647 0.277994869347333 0.982467346975626 1 GO:0008201 heparin binding 26/3944 172/18639 0.151162790697674 0.714382164253031 0.982596142367188 1 GO:0016500 protein-hormone receptor activity 8/3944 67/18639 0.119402985074627 0.564288093003542 0.982867373466107 1 GO:0015020 glucuronosyltransferase activity 3/3944 34/18639 0.0882352941176471 0.416992304021 0.984472119319589 1 GO:0015035 protein-disulfide reductase activity 3/3944 34/18639 0.0882352941176471 0.416992304021 0.984472119319589 1 GO:0003678 DNA helicase activity 9/3944 74/18639 0.121621621621622 0.57477317581273 0.984478911274189 1 GO:0000400 four-way junction DNA binding 1/3944 18/18639 0.0555555555555556 0.262550709939148 0.986180631452488 1 GO:0004970 glutamate-gated receptor activity 1/3944 18/18639 0.0555555555555556 0.262550709939148 0.986180631452488 1 GO:0005372 water transmembrane transporter activity 1/3944 18/18639 0.0555555555555556 0.262550709939148 0.986180631452488 1 GO:0016859 cis-trans isomerase activity 4/3944 42/18639 0.0952380952380952 0.450086931324254 0.986430673593855 1 GO:0031492 nucleosomal DNA binding 4/3944 42/18639 0.0952380952380952 0.450086931324254 0.986430673593855 1 GO:0005104 fibroblast growth factor receptor binding 2/3944 27/18639 0.0740740740740741 0.350067613252197 0.986605726954705 1 GO:0000175 3'-5'-RNA exonuclease activity 3/3944 35/18639 0.0857142857142857 0.405078238191828 0.987104094533574 1 GO:0016741 transferase activity, transferring one-carbon groups 33/3944 215/18639 0.153488372093023 0.725372659087693 0.987852595282519 1 GO:0008527 taste receptor activity 2/3944 28/18639 0.0714285714285714 0.33756519849319 0.989099776291793 1 GO:0016866 intramolecular transferase activity 2/3944 28/18639 0.0714285714285714 0.33756519849319 0.989099776291793 1 GO:0097718 disordered domain specific binding 2/3944 28/18639 0.0714285714285714 0.33756519849319 0.989099776291793 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/3944 36/18639 0.0833333333333333 0.393826064908722 0.989304245103496 1 GO:0022843 voltage-gated monoatomic cation channel activity 20/3944 143/18639 0.13986013986014 0.660966822224429 0.989414098373961 1 GO:0003743 translation initiation factor activity 5/3944 51/18639 0.0980392156862745 0.463324782245555 0.990284068095501 1 GO:0005010 insulin-like growth factor receptor activity 5/3944 51/18639 0.0980392156862745 0.463324782245555 0.990284068095501 1 GO:0005021 vascular endothelial growth factor receptor activity 5/3944 51/18639 0.0980392156862745 0.463324782245555 0.990284068095501 1 GO:0005030 neurotrophin receptor activity 5/3944 51/18639 0.0980392156862745 0.463324782245555 0.990284068095501 1 GO:0015464 acetylcholine receptor activity 1/3944 20/18639 0.05 0.236295638945233 0.991414797967571 1 GO:0140664 ATP-dependent DNA damage sensor activity 1/3944 20/18639 0.05 0.236295638945233 0.991414797967571 1 GO:0140939 histone H4 methyltransferase activity 1/3944 20/18639 0.05 0.236295638945233 0.991414797967571 1 GO:0005249 voltage-gated potassium channel activity 12/3944 98/18639 0.122448979591837 0.578683197416898 0.992290272685891 1 GO:0022832 voltage-gated channel activity 25/3944 175/18639 0.142857142857143 0.675130396986381 0.992342214198512 1 GO:0005261 monoatomic cation channel activity 55/3944 341/18639 0.161290322580645 0.762243996597527 0.992405168474533 1 GO:0005003 ephrin receptor activity 5/3944 53/18639 0.0943396226415094 0.445840828198553 0.993027782386278 1 GO:0005005 transmembrane-ephrin receptor activity 5/3944 53/18639 0.0943396226415094 0.445840828198553 0.993027782386278 1 GO:0016860 intramolecular oxidoreductase activity 5/3944 53/18639 0.0943396226415094 0.445840828198553 0.993027782386278 1 GO:0038064 collagen receptor activity 5/3944 53/18639 0.0943396226415094 0.445840828198553 0.993027782386278 1 GO:0004252 serine-type endopeptidase activity 25/3944 176/18639 0.142045454545455 0.671294428821685 0.993066687579878 1 GO:0000217 DNA secondary structure binding 3/3944 39/18639 0.0769230769230769 0.363531752223436 0.993942695641146 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/3944 39/18639 0.0769230769230769 0.363531752223436 0.993942695641146 1 GO:0140223 general transcription initiation factor activity 7/3944 68/18639 0.102941176470588 0.486491021357833 0.994276255478254 1 GO:0099095 ligand-gated monoatomic anion channel activity 4/3944 47/18639 0.0851063829787234 0.402205342885503 0.994361881732009 1 GO:0005243 gap junction channel activity 1/3944 22/18639 0.0454545454545455 0.214814217222939 0.994666801276767 1 GO:0005244 voltage-gated monoatomic ion channel activity 24/3944 173/18639 0.138728323699422 0.655617957767121 0.99477105993805 1 GO:0030515 snoRNA binding 2/3944 32/18639 0.0625 0.295369548681542 0.995264455656864 1 GO:0016853 isomerase activity 25/3944 180/18639 0.138888888888889 0.65637677484787 0.995376701894028 1 GO:0140101 catalytic activity, acting on a tRNA 18/3944 139/18639 0.129496402877698 0.611988705181899 0.995513988840727 1 GO:0003697 single-stranded DNA binding 15/3944 121/18639 0.12396694214876 0.585856956062562 0.995622074197684 1 GO:0016917 GABA receptor activity 1/3944 23/18639 0.0434782608695652 0.205474468648029 0.99579663614621 1 GO:0005004 GPI-linked ephrin receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0005008 hepatocyte growth factor receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0005009 insulin receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0005011 macrophage colony-stimulating factor receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0005020 stem cell factor receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0008288 boss receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0036332 placental growth factor receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0038062 protein tyrosine kinase collagen receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0060175 brain-derived neurotrophic factor receptor activity 4/3944 49/18639 0.0816326530612245 0.385788798277932 0.996065848577333 1 GO:0042923 neuropeptide binding 2/3944 33/18639 0.0606060606060606 0.286418956297252 0.996163502936431 1 GO:0048027 mRNA 5'-UTR binding 1/3944 24/18639 0.0416666666666667 0.196913032454361 0.996687164027568 1 GO:0140612 DNA damage sensor activity 1/3944 24/18639 0.0416666666666667 0.196913032454361 0.996687164027568 1 GO:0005006 epidermal growth factor receptor activity 4/3944 50/18639 0.08 0.378073022312373 0.996719114021946 1 GO:0005007 fibroblast growth factor receptor activity 4/3944 50/18639 0.08 0.378073022312373 0.996719114021946 1 GO:0005017 platelet-derived growth factor receptor activity 4/3944 50/18639 0.08 0.378073022312373 0.996719114021946 1 GO:0005019 platelet-derived growth factor beta-receptor activity 4/3944 50/18639 0.08 0.378073022312373 0.996719114021946 1 GO:0019825 oxygen binding 2/3944 34/18639 0.0588235294117647 0.277994869347333 0.996894214412483 1 GO:0005201 extracellular matrix structural constituent 22/3944 168/18639 0.130952380952381 0.618869530570849 0.997476612510387 1 GO:0005216 monoatomic ion channel activity 72/3944 448/18639 0.160714285714286 0.759521696609678 0.997499273639942 1 GO:0015276 ligand-gated monoatomic ion channel activity 25/3944 186/18639 0.134408602150538 0.635203330497939 0.997537957279367 1 GO:0005179 hormone activity 16/3944 132/18639 0.121212121212121 0.572837912594505 0.99759570550882 1 GO:0008066 glutamate receptor activity 1/3944 26/18639 0.0384615384615385 0.181765876111718 0.997942276515661 1 GO:0008143 poly(A) binding 1/3944 26/18639 0.0384615384615385 0.181765876111718 0.997942276515661 1 GO:0055106 ubiquitin-protein transferase regulator activity 2/3944 36/18639 0.0555555555555556 0.262550709939148 0.997968926182247 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/3944 36/18639 0.0555555555555556 0.262550709939148 0.997968926182247 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/3944 36/18639 0.0555555555555556 0.262550709939148 0.997968926182247 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/3944 36/18639 0.0555555555555556 0.262550709939148 0.997968926182247 1 GO:0022834 ligand-gated channel activity 25/3944 188/18639 0.132978723404255 0.628445848258599 0.998015761789674 1 GO:0008227 G protein-coupled amine receptor activity 2/3944 41/18639 0.0487804878048781 0.230532330678276 0.999305132995306 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 3/3944 56/18639 0.0535714285714286 0.253173898869893 0.9997935725021 1 GO:0019843 rRNA binding 4/3944 65/18639 0.0615384615384615 0.290825401778749 0.999806812857756 1 GO:0022836 gated channel activity 43/3944 318/18639 0.135220125786164 0.639038520417926 0.999843400252095 1 GO:0005109 frizzled binding 1/3944 38/18639 0.0263157894736842 0.124366125760649 0.999881972733343 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/3944 53/18639 0.0377358490566038 0.178336331279421 0.999949540656387 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/3944 73/18639 0.0547945205479452 0.258954124871489 0.999960036794487 1 GO:0098960 postsynaptic neurotransmitter receptor activity 3/3944 69/18639 0.0434782608695652 0.205474468648029 0.999986200990888 1 GO:0030594 neurotransmitter receptor activity 6/3944 97/18639 0.0618556701030928 0.292324501787917 0.999989704750178 1 GO:0022824 transmitter-gated monoatomic ion channel activity 2/3944 63/18639 0.0317460317460317 0.150028977108085 0.999994534734128 1 GO:0022835 transmitter-gated channel activity 2/3944 63/18639 0.0317460317460317 0.150028977108085 0.999994534734128 1 GO:0001653 peptide receptor activity 9/3944 128/18639 0.0703125 0.332290742266734 0.99999711165292 1 GO:0008528 G protein-coupled peptide receptor activity 8/3944 122/18639 0.0655737704918033 0.309895919928175 0.999997952421915 1 GO:0003730 mRNA 3'-UTR binding 22/3944 262/18639 0.083969465648855 0.39683237074772 0.99999999436683 1 GO:0003735 structural constituent of ribosome 1/3944 175/18639 0.00571428571428571 0.0270052158794552 1 1 GO:0030371 translation repressor activity 14/3944 329/18639 0.0425531914893617 0.201102671442752 1 1 GO:0045182 translation regulator activity 17/3944 356/18639 0.047752808988764 0.225675610228594 1 1 GO:1903231 mRNA base-pairing translational repressor activity 3/3944 298/18639 0.0100671140939597 0.0475763031433356 1 1