category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	83/973	222/9376	3.60271473940539	RPS27L/RPS19/RPS27/RPL41/RPL23A/RPS28/FAU/UBA52/RPL36AL/RPS25/RPL21/RPL32/RPLP2/RPS15/RPLP1/RPS14/RPL30/RPS26/RPS13/RPL26/RPL38/RPL18/RPL19/RPL10/RPS29/RPS15A/RPL18A/RPL8/RPS11/RPL36/RPL12/RPL11/RPL9/RPS12/RPL39/RPL24/RPS20/RPL15/RPL37A/RPL35A/MRPL27/RPL27A/RPL27/RPL13A/RPL31/RPS4Y1/RPS24/RPL22/MRPL12/RPS10/RPL34/RPS16/MRPS21/RPS27A/MRPS10/MRPL28/MRPL24/MRPL47/RPL17/MRPS6/MRPL4/RPL35/MRPS16/RPL7/MRPL50/MRPS34/RPS21/MRPS33/MRPS7/MRPL43/RPL29/MRPL40/MRPS14/MRPS11/MRPL36/MRPS5/MRPS22/MRPL46/MRPS15/MRPS2/MRPL54/RPL26L1/RPL13	13.3543416034909
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	85/973	238/9376	3.44149170459551	RPS27L/RPS19/RPS27/RPL41/RPL23A/RPS28/FAU/UBA52/RPL36AL/RPS25/RPL21/RPL32/RPLP2/RPS15/RPLP1/RPS14/RPL30/RPS26/RPS13/RPL26/RPL38/RPL18/RPL19/RPL10/RPS29/RPS15A/RPL18A/C1QA/RPL8/RPS11/RPL36/RPL12/RPL11/RPL9/RPS12/C1QB/RPL39/RPL24/RPS20/RPL15/RPL37A/RPL35A/RPL27A/RPL27/RPL13A/RPL31/RPS4Y1/RPS24/RPL22/C1QC/FCGR2A/RPS10/C5AR1/RPL34/RPS16/C3AR1/NFKBIA/ISG15/RPS27A/RPL17/CASP1/CXCL10/HBEGF/RPL35/JUN/RPL7/TLR2/RPS21/RPL29/PRKCB/FOS/IL6R/TLR4/F13A1/IFNAR1/CYBB/C2/MX2/CHUK/IL6ST/STAT3/RPL26L1/MAPK9/ADAR/RPL13	12.9820426401974
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	46/973	155/9376	2.85976859065743	HLA-DRA/TUBA4A/HLA-DRB1/HLA-DPA1/HLA-B/CTSS/HLA-DQA1/TUBB1/HLA-DPB1/FCGR3A/MSR1/HLA-DMA/HLA-DQB1/ITGB2/NCF2/HLA-F/HLA-DMB/HLA-DQA2/HLA-A/MARCO/FCGR2A/ATP6V0E1/FCGR1A/HLA-DOA/ATP6V0B/TUBB4B/TUBA1A/ITGAM/CD14/TLR2/DYNC1LI1/M6PR/STX18/OLR1/DYNC1LI2/SEC61G/TLR4/STX7/RAC1/HLA-C/SEC61A1/NCF4/CYBB/RAB7A/DYNC1H1/CLEC7A	7.94439123062503
Human Diseases	Immune disease	hsa05330	Allograft rejection	18/973	39/9376	4.44746620286189	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-F/HLA-DMB/HLA-DQA2/FAS/CD86/HLA-A/HLA-DOA/IL10/HLA-C/CD40	7.34097116096655
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	49/973	205/9376	2.30328127741709	CDKN1A/GADD45A/BAX/HLA-DRA/DDB2/HLA-DRB1/HLA-DPA1/MDM2/HLA-B/VIM/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/CD44/HLA-F/HLA-DMB/HLA-DQA2/FAS/HLA-A/B2M/RELB/PSMD12/CDK4/GADD45B/NFKBIA/ISG15/PSMD8/HLA-DOA/PSMC4/CXCL10/JUN/PSMD7/TLR2/PSMD3/NFKBIE/PSMD13/RAC1/HLA-C/CIR1/MAP2K4/IFNAR1/NFKB2/MAP2K3/CHUK/ADRM1/STAT3/MAPK9/CD40	6.41994957152743
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	27/973	82/9376	3.17288747399293	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-B/CTSS/HLA-DQA1/HSP90AB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-F/HLA-DMB/HLA-DQA2/HLA-A/B2M/CD4/HSPA4/HLA-DOA/IFI30/CTSB/HSPA1B/NFYC/LGMN/PSME1/PSME2/HLA-C	6.72461933603613
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	58/973	268/9376	2.08544124188922	SOD1/DDIT3/BAX/UBA52/TUBA4A/UBB/UBC/TUBB1/ATF4/MT-ND2/COX6A1/PSMA7/COX6B1/CALM2/PSMD12/UQCR10/COX4I1/NDUFS3/NDUFA5/PSMB6/NDUFB10/CALM1/PSMD8/UQCRQ/RPS27A/VDAC2/PPIF/PSMB5/TUBB4B/TUBA1A/PSMC4/NDUFA12/COX7A2/SDHA/UCHL1/PSMD7/KIF5B/PSMD3/NDUFA2/PSMD13/DUSP1/NDUFB3/PSMB2/PINK1/COX8A/PSMA5/NDUFB4/PSMB4/MT-ND4/SLC25A4/EIF2S1/GNAI3/NDUFA6/NDUFA11/GNAS/ADRM1/MAPK9/TXN	6.13461173993969
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	26/973	78/9376	3.21205892428914	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/FCGR3A/HLA-DMA/HLA-DQB1/ITGB2/NCF2/HLA-DMB/HLA-DQA2/FCGR2A/NFKBIA/FCGR1A/HLA-DOA/ITGAM/JUN/TLR2/IL10/PRKCB/FOS/TLR4/NCF4/CYBB/PTPN6	6.67535087561558
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	59/973	275/9376	2.06739792581519	SOD1/DDIT3/BAX/TUBA4A/C1QA/TUBB1/ATF4/C1QB/MT-ND2/COX6A1/PSMA7/NCF2/COX6B1/C1QC/PSMD12/UQCR10/COX4I1/NDUFS3/NDUFA5/PSMB6/NDUFB10/PSMD8/UQCRQ/CCL5/VDAC2/PPIF/CSNK2A1/PSMB5/TUBB4B/TUBA1A/PSMC4/NDUFA12/COX7A2/HSPA1B/SDHA/PSMD7/KIF5B/PSMD3/NDUFA2/PSMD13/NDUFB3/PSMB2/COX8A/PSMA5/RAC1/NDUFB4/CREB5/PSMB4/MT-ND4/NCF4/CYBB/SLC25A4/EIF2S1/STIP1/PPP3CB/NDUFA6/NDUFA11/ADRM1/MAPK9	6.11326216620971
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	31/973	105/9376	2.84496647579895	SQSTM1/MAP1LC3B/UBA52/UBB/UBC/ATF4/GABARAPL1/OPTN/BNIP3L/RPS27A/CSNK2A1/JUN/GABARAP/MAP1LC3B2/BNIP3/FUNDC1/NRAS/FOXO3/PINK1/GABARAPL2/MRAS/FKBP8/TOMM20/RAB7A/TFE3/EIF2S1/HIF1A/SIAH1/CCZ1/MAPK9/SP1	6.46911266372889
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	72/973	368/9376	1.88533893382189	SQSTM1/SOD1/MAP1LC3B/DDIT3/BAX/TUBA4A/GPX1/TUBB1/ATF4/MT-ND2/COX6A1/PSMA7/SRSF3/OPTN/COX6B1/GPX3/PSMD12/FUS/UQCR10/COX4I1/NDUFS3/NDUFA5/PSMB6/NDUFB10/PSMD8/UQCRQ/MATR3/PSMB5/CASP1/TUBB4B/TUBA1A/PSMC4/NDUFA12/SEC13/COX7A2/SDHA/PSMD7/KIF5B/PSMD3/TARDBP/NDUFA2/MAP1LC3B2/WIPI2/PSMD13/POM121/ATXN2/NDUFB3/PSMB2/PINK1/ANXA11/COX8A/ACTR10/NRBF2/PSMA5/VAPB/RAC1/NDUFB4/PSMB4/MT-ND4/DERL1/CHCHD10/POM121C/EIF2S1/MAP2K3/PPP3CB/DCTN4/SETX/NDUFA6/DCTN5/NDUFA11/ADRM1/DCTN2	5.89581924517792
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	87/973	480/9376	1.74655704008222	SQSTM1/SOD1/MAP1LC3B/DDIT3/BAX/UBA52/TUBA4A/GPX1/UBB/UBC/TUBB1/ATF4/MT-ND2/COX6A1/PSMA7/OPTN/FAS/COX6B1/CALM2/GPX3/PSMD12/FUS/UQCR10/COX4I1/NDUFS3/NDUFA5/PSMB6/NDUFB10/CALM1/PSMD8/UQCRQ/MAP2K2/RPS27A/FRAT1/VDAC2/PPIF/CSNK2A1/PSMB5/TUBB4B/TUBA1A/PSMC4/NDUFA12/COX7A2/SDHA/UCHL1/PSMD7/KIF5B/PLCB2/PSMD3/TARDBP/NDUFA2/MAP1LC3B2/WIPI2/PSMD13/PRKCB/ATXN2/NDUFB3/PSMB2/NRAS/FRAT2/PINK1/COX8A/ACTR10/NRBF2/PSMA5/CSNK1A1/VAPB/RAC1/NDUFB4/PSMB4/MT-ND4/DERL1/CYBB/SLC25A4/CAPN2/EIF2S1/MAP2K3/ATXN1/PPP3CB/DCTN4/NDUFA6/DCTN5/NDUFA11/ADRM1/DCTN2/MAPK9/GNAQ	5.71361671514421
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	62/973	308/9376	1.93974986986292	SOD1/BBC3/BAX/TUBA4A/GPX1/TUBB1/MT-ND2/COX6A1/PSMA7/COX6B1/GPX3/PSMD12/UQCR10/COX4I1/NDUFS3/NDUFA5/PSMB6/NDUFB10/PSMD8/UQCRQ/VDAC2/PPIF/PSMB5/TUBB4B/TUBA1A/PSMC4/NDUFA12/COX7A2/SDHA/POLR2B/SOD2/PSMD7/KIF5B/PLCB2/PSMD3/NDUFA2/WIPI2/PSMD13/NDUFB3/PSMB2/AP2B1/COX8A/ACTR10/NRBF2/PSMA5/NDUFB4/CREB5/PSMB4/MT-ND4/POLR2E/SLC25A4/POLR2D/DCTN4/NDUFA6/DCTN5/NDUFA11/ADRM1/DCTN2/MAPK9/POLR2J3/SP1/GNAQ	5.70632828938402
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	18/973	46/9376	3.77067786764377	PSMA7/PSMD12/PSMB6/PSMD8/PSMB5/PSMC4/PSMD7/PSMD3/PSMD13/PSMB2/PSMA5/PSME1/PSMB9/PSMB4/PSME2/PSMB8/ADRM1/POMP	6.4098668192828
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	30/973	109/9376	2.6521587448259	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HSP90AB1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-DQA2/CD4/NFKBIA/STAT6/HLA-DOA/JUN/NFKBIE/FOS/SMAD2/IL6R/AHR/TGFBR1/SMAD4/IL4R/NFATC3/PPP3CB/HIF1A/CHUK/IL6ST/STAT3/MAPK9	5.90364612816993
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	47/973	216/9376	2.09676068668874	DDIT3/BAX/HSP90AB1/ATF4/NCF2/POU2F2/LY96/FAS/IL18/CALM2/NFKBIA/CALM1/CCL3/CCL5/HSPA4/ABCA1/TNFRSF10B/CASP1/JUN/MMP9/CD14/HSPA1B/SOD2/TLR2/ABCG1/PLCB2/OLR1/FOS/NRAS/TLR4/RAP1B/RAC1/CXCL3/CXCL2/MAP2K4/NCF4/CYBB/PYCARD/EIF2S1/MAP2K3/TNFRSF10A/NFATC3/PPP3CB/CHUK/STAT3/MAPK9/CD40	5.54901488903964
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	48/973	227/9376	2.03760566122307	HMOX1/SOD1/AKR1C1/GSTO1/MT-ND2/COX6A1/NCF2/COX6B1/ACP1/GSTT1/UQCR10/COX4I1/NDUFS3/NDUFA5/NFKBIA/NDUFB10/UQCRQ/MAP2K2/VDAC2/PPIF/NDUFA12/JUN/COX7A2/SDHA/SOD2/VEGFA/NDUFA2/GRB2/NDUFB3/FOS/NRAS/FOXO3/AHR/COX8A/CBR1/RAC1/NDUFB4/MT-ND4/AKR1A1/MAP2K4/SLC25A4/GSTM3/SOS2/NDUFA6/HIF1A/CHUK/NDUFA11/MAPK9	5.38497044408133
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	51/973	248/9376	1.98163312667838	BAX/TUBA4A/HSP90AB1/TUBB1/SKP1/LY96/GCC2/IL18/PTPRC/BRK1/FBXO22/NFKBIA/ACTR3/CYTH4/MAP2K2/ARPC1B/NCKAP1L/TNFRSF10B/CASP1/TUBB4B/TUBA1A/JUN/CD14/TLR2/KIF5B/DYNC1LI1/M6PR/DYNC1LI2/FOS/ACTR10/TLR4/BIRC3/RAC1/DYNLL2/PKN1/MYL12B/MAP2K4/ARF1/PYCARD/RAB7A/MAP2K3/DYNC1H1/TNFRSF10A/DCTN4/ARL8B/CHUK/DCTN5/VPS33A/DCTN2/MAPK9/TXN	5.33104203776144
Human Diseases	Immune disease	hsa05310	Asthma	14/973	32/9376	4.2158273381295	HLA-DRA/HLA-DRB1/HLA-DPA1/FCER1G/HLA-DQA1/PRG2/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-DQA2/HLA-DOA/IL10/CD40	6.20049231718995
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	27/973	99/9376	2.62804821078202	HLA-DRA/HLA-DRB1/HLA-DPA1/C1QA/HLA-DQA1/HLA-DPB1/FCGR3A/HLA-DMA/HLA-DQB1/C1QB/ITGB2/FPR3/HLA-DMB/HLA-DQA2/C1QC/FCGR2A/C5AR1/C3AR1/PTAFR/FCGR1A/SELPLG/HLA-DOA/KRT10/ITGAM/FPR1/IL10/C2	5.54122719423506
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	26/973	95/9376	2.63726943257424	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/ITGB2/HLA-DMB/HLA-DQA2/CD86/IL18/TNFSF13B/ATP6V0E1/CCL3/CCL5/HLA-DOA/ACP5/ATP6V0B/JUN/TLR2/VEGFA/FOS/TLR4/CXCL3/CXCL2	5.45769732323102
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	40/973	181/9376	2.12954182825799	BAX/HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/CTSS/FCER1G/HLA-DQA1/HLA-DPB1/FCGR3A/HLA-DMA/HLA-DQB1/CTSD/ITGB2/HLA-DMB/HLA-DQA2/LSP1/IL18/CALM2/FCGR2A/CEBPG/CEBPB/CALM1/PLK3/FCGR1A/ITGAX/HLA-DOA/ATP6V0B/ITGAM/CD14/NFYC/TLR2/IL10/HSPA9/TLR4/CARD9/RAB7A/PPP3CB/CLEC7A/MAPK9	5.22144388749492
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	46/973	224/9376	1.97885773014242	CDKN1A/BAX/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DQA1/HLA-DPB1/ATF4/HLA-DMA/HLA-DQB1/ITGB2/HLA-F/HLA-DMB/HLA-DQA2/HLA-A/B2M/SPI1/RELB/CD4/CDK4/ANAPC16/NFKBIA/MAP2K2/VDAC2/HLA-DOA/JUN/MMP7/FOS/NRAS/SMAD2/TGFBR1/SMAD4/FOSL1/ANAPC13/CREB5/HLA-C/MAP2K4/SLC25A4/NFKB2/NFATC3/PPP3CB/CHUK/MAPK9/CD40/ZFP36	5.04557254532713
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/973	44/9376	3.5040642810427	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-F/HLA-DMB/HLA-DQA2/FAS/CD86/HLA-A/HLA-DOA/HLA-C	5.66512273190017
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	22/973	75/9376	2.82661185337444	CDKN1A/GADD45A/BBC3/BAX/DDB2/MDM2/SERPINE1/TP53I3/FAS/SESN1/CDK4/GADD45B/TNFRSF10B/SESN2/PPM1D/EI24/SIVA1/IGFBP3/TNFRSF10A/RRM2B/PMAIP1/SIAH1	5.40426899437203
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	18/973	54/9376	3.21205892428914	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-F/HLA-DMB/HLA-DQA2/FAS/CD86/HLA-A/HLA-DOA/IL10/HLA-C/CD40	5.5470732212341
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/973	45/9376	3.42619618590842	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-F/HLA-DMB/HLA-DQA2/FAS/CD86/HLA-A/HLA-DOA/HLA-C	5.55127771469739
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	38/973	174/9376	2.1044523986722	DDIT3/BAX/RBX1/HSP90AB1/ATF4/DNAJA1/SKP1/BAG1/SAR1B/DNAJB2/SEC13/HSPA1B/RNF5/SEC63/DAD1/DNAJA2/SSR4/PPP1R15A/DNAJB11/SEC62/UBE2D2/UBXN2A/SEC61G/EDEM3/SSR2/DERL1/SEC61A1/SEC31A/CAPN2/NSFL1C/RAD23A/EIF2S1/CRYAB/SEC23B/UBXN6/UBE2D3/MAPK9/HSPH1	5.00386274975085
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	37/973	169/9376	2.10969550648577	SQSTM1/MAP1LC3B/UBA52/UBB/UBC/GABARAPL1/CTSD/OPTN/DDIT4/RRAGD/MAP2K2/RPS27A/WDR45/CTSB/GABARAP/PPP2CA/MAP1LC3B2/IRS2/WIPI2/BNIP3/NRAS/GABARAPL2/NRBF2/MRAS/ATG12/STX7/SUPT20H/RPS6KB2/RAB7A/EIF2S1/ATG5/RRAGA/ATG4C/HIF1A/VPS33A/ATG4B/MAPK9	4.9535093232171
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	41/973	196/9376	2.0157308555488	CDKN1A/MAP1LC3B/BAX/UBA52/UBB/UBC/HLA-B/HLA-F/FAS/CD86/HLA-A/CLEC2B/CALM2/GNG5/CDK4/NFKBIA/CALM1/MAP2K2/RPS27A/HCK/JUN/VEGFA/MAP1LC3B2/FOS/NRAS/GNB1/RAC1/GNB2/CXCL3/CXCL2/HLA-C/MAP2K4/IFNAR1/NFATC3/PPP3CB/HIF1A/CHUK/IL6ST/STAT3/MAPK9/ZFP36	4.8900152909366
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	15/973	42/9376	3.44149170459551	HMOX1/FTL/FTH1/MAP1LC3B/SLC3A2/GPX4/SAT1/VDAC2/SAT2/NCOA4/MAP1LC3B2/CYBB/ATG5/ACSL1/PCBP2	5.39598677407535
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	32/973	142/9376	2.17153279388562	SQSTM1/TYROBP/TREM2/JUND/FCGR3A/NCF2/SPI1/RELB/OSCAR/FCGR2A/LILRB4/NFKBIA/SIRPA/FCGR1A/ACP5/JUN/JUNB/LILRB1/LILRB2/LILRA2/LCP2/GRB2/FOS/TGFBR1/FOSL1/RAC1/IFNAR1/NCF4/NFKB2/PPP3CB/CHUK/MAPK9	4.78661572967614
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	20/973	70/9376	2.75319336367641	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/ITGB2/HLA-F/HLA-DMB/HLA-DQA2/CD86/HLA-A/EIF4G2/HLA-DOA/RAC1/HLA-C/CD40/SNTB1	5.00982078832038
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	31/973	137/9376	2.18044875882401	GADD45A/DDIT3/BBC3/BAX/TUBA4A/CTSS/ATF4/CTSD/FAS/BCL2A1/GADD45B/NFKBIA/ENDOG/MAP2K2/MCL1/TNFRSF10B/TUBA1A/JUN/CTSB/CTSZ/CTSH/FOS/NRAS/BIRC3/CAPN2/EIF2S1/TNFRSF10A/CHUK/PMAIP1/CTSC/MAPK9	4.73608857972174
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	19/973	66/9376	2.7740508891588	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-DQA2/IL18/STAT6/HLA-DOA/JUN/TLR2/IL10/SMAD2/IL4R/TLR4/STAT3	4.92139334203611
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	16/973	50/9376	3.08357656731757	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-DQA2/CD86/CXCR4/TNFSF13B/MADCAM1/HLA-DOA/IL10/CD40	5.0265688750447
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	66/973	388/9376	1.63914347167332	APOE/DDIT3/TUBA4A/TUBB1/ATF4/MT-ND2/COX6A1/PSMA7/FAS/COX6B1/CALM2/PSMD12/UQCR10/COX4I1/NDUFS3/NDUFA5/PSMB6/LPL/NDUFB10/CALM1/PSMD8/UQCRQ/MAP2K2/FRAT1/VDAC2/PPIF/CSNK2A1/PSMB5/TUBB4B/TUBA1A/PSMC4/NDUFA12/COX7A2/SDHA/PSMD7/KIF5B/PLCB2/PSMD3/NDUFA2/IRS2/PSENEN/WIPI2/PSMD13/NDUFB3/PSMB2/NRAS/FRAT2/COX8A/NRBF2/PSMA5/CSNK1A1/NDUFB4/PSMB4/MT-ND4/CYBB/SLC25A4/CAPN2/EIF2S1/INSR/PPP3CB/NDUFA6/CHUK/NDUFA11/ADRM1/MAPK9/GNAQ	4.37529726247942
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	41/973	214/9376	1.84618340040918	BAX/HLA-B/RBX1/SKP1/HLA-F/FAS/HLA-A/B2M/CXCR4/CALM2/CD4/GNG5/NFKBIA/CALM1/MAP2K2/JUN/TLR2/CUL5/WEE1/PRKCB/FOS/NRAS/TLR4/GNB1/RAC1/GNB2/SAMHD1/RPS6KB2/CRK/HLA-C/BST2/LIMK2/MAP2K3/GNAI3/NFATC3/PPP3CB/CHUK/AP1S2/CFL2/MAPK9/GNAQ	4.26089783438066
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	29/973	133/9376	2.10112125122673	CDKN1A/GADD45A/MDM2/GABARAPL1/GADD45B/MAP2K2/PLK3/GABARAP/SOD2/PRMT1/CDKN2D/BCL6/IL10/GRB2/IRS2/HOMER3/BNIP3/NRAS/FOXO3/TGFBR1/SMAD4/GABARAPL2/G6PC3/ATG12/INSR/SOS2/CHUK/STAT3/MAPK9	4.35190458527922
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	20/973	78/9376	2.47081455714549	C1QA/C1QB/ITGB2/LY96/CALM2/C1QC/CALM1/CASP1/ITGAM/JUN/CD14/IL10/IRF8/FOS/TLR4/C2/PYCARD/GNAI3/CFL2/MAPK9	4.43849082594599
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	24/973	103/9376	2.24532274319241	C1QA/SERPINE1/C1QB/FAS/C1QC/NFKBIA/CCL3/CCL5/JUN/PPP2CA/TLR2/PLCB2/IL10/FOS/SMAD2/TGFBR1/TLR4/GNA15/MAP2K4/GNAI3/CHUK/GNAS/MAPK9/GNAQ	4.32429465296728
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	16/973	56/9376	2.75319336367641	ITGB2/IL18/NFKBIA/SAR1B/CASP1/ITGAM/CD14/HSPA1B/TLR2/BNIP3/TLR4/CXCL3/CXCL2/ARF1/PYCARD/NFKB2	4.47755317248769
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	39/973	205/9376	1.83322387386258	MT-ND2/COX6A1/CTSD/NCF2/COX6B1/UQCR10/COX4I1/TNNI3/NDUFS3/NDUFA5/NDUFB10/UQCRQ/VDAC2/PPIF/MPC2/NDUFA12/MMP9/COX7A2/SDHA/PLCB2/NDUFA2/PRKCB/NDUFB3/PDK4/SMAD2/TGFBR1/COX8A/RAC1/NDUFB4/MT-ND4/G6PD/NCF4/CYBB/SLC25A4/INSR/NDUFA6/NDUFA11/MAPK9/SP1	4.10445185140075
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	32/973	157/9376	1.96406150784559	DDIT3/BAX/ATF4/COX6A1/FAS/COX6B1/UQCR10/COX4I1/NDUFS3/NDUFA5/NDUFB10/UQCRQ/NDUFA12/JUN/COX7A2/ADIPOR1/SDHA/NDUFA2/IRS2/ADIPOR2/NDUFB3/FOS/IL6R/COX8A/MLXIP/RAC1/NDUFB4/EIF2S1/INSR/NDUFA6/NDUFA11/MAPK9	4.14512410998832
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	25/973	112/9376	2.15093231537219	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DMB/LY96/HLA-DQA2/NFKBIA/HLA-DOA/PPIF/HSPA1B/TLR2/IL10/ALOX5/TLR4/BIRC3/MAP2K3/GNAI3/CHUK/STAT3/MAPK9/CD40	4.16950403896266
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	36/973	187/9376	1.85509285466966	MAP1LC3B/TXNIP/HSP90AB1/GABARAPL1/IL18/NFKBIA/CCL5/GPSM3/VDAC2/CASP1/JUN/IFI16/CTSB/GABARAP/PLCB2/CARD16/P2RX7/TRPV2/MAP1LC3B2/GABARAPL2/TLR4/BIRC3/ATG12/CARD9/CXCL3/PKN1/CXCL2/IFNAR1/CYBB/PYCARD/SHARPIN/ATG5/TRIP6/CHUK/MAPK9/TXN	4.01906316217059
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	45/973	253/9376	1.71394448529262	SQSTM1/MAP1LC3B/BAX/UBA52/UBB/UBC/MDM2/RBX1/SKP1/CD44/IL18/RRAGD/NFKBIA/ACTR3/CYTH4/CCL5/RPS27A/ARPC1B/CASP1/JUN/HK3/CD14/PLCB2/MAP1LC3B2/WIPI2/ILK/BNIP3/UBE2D2/FOXO3/TLR4/ATG12/RAC1/RPS6KB2/CRK/MYL12B/ARF1/PYCARD/SHARPIN/CAPN2/ATG5/RRAGA/UBE2D3/CHUK/CAPNS1/MAPK9	3.91724507359298
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/973	227/9376	1.74045483562804	CDKN1A/BAX/MDM2/HLA-B/ATF4/HLA-F/FAS/HLA-A/B2M/CXCR4/CALM2/GNG5/CDK4/NFKBIA/CALM1/CCL3/CCL5/MAP2K2/VEGFA/PLCB2/PTGER4/GRB2/PRKCB/NRAS/IL6R/GNB1/RAC1/GNB2/CREB5/RPS6KB2/CRK/HLA-C/GNAI3/NFATC3/PPP3CB/SOS2/CHUK/GNAS/STAT3/SP1/GNAQ	3.84281577678947
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/973	44/9376	2.84705222834719	RAB11A/DYNC1LI1/DYNC1LI2/VAMP2/RAB11B/ARHGDIA/DYNLL2/CREB5/DYNC1H1/DCTN4/DCTN5/GNAS/DCTN2	4.17871763318289
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	33/973	173/9376	1.8381146445354	BAX/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-DQA2/FAS/IL18/CDK4/NFKBIA/CCL5/MAP2K2/HLA-DOA/TNFRSF10B/CASP1/CXCL10/HNRNPUL1/RAB11A/PRKCB/RAB11B/TLR4/IFNAR1/PYCARD/SLC25A4/EIF2S1/MX2/TNFRSF10A/CHUK/ADAR	3.78605262597281
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	21/973	93/9376	2.17591088419587	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/HLA-DMB/HLA-DQA2/CD4/NFKBIA/STAT6/HLA-DOA/JUN/NFKBIE/FOS/IL4R/NFATC3/PPP3CB/CHUK/MAPK9	3.87789982272115
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	20/973	87/9376	2.21521305123389	CDKN1A/GADD45A/BBC3/BAX/DDB2/GADD45B/MAP2K2/JUN/GRB2/FOS/NRAS/SMAD2/TGFBR1/SMAD4/EREG/RAC1/RPS6KB2/SOS2/PMAIP1/MAPK9	3.87482815378601
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	22/973	100/9376	2.11995889003083	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/CD44/HLA-DMB/CD37/HLA-DQA2/CD4/FCGR1A/HLA-DOA/ITGAM/CD14/GP9/CD59/CD33/IL6R/IL4R/ITGA2B	3.83130377946467
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	33/973	180/9376	1.76663240835903	BAX/HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/SRSF3/POU2F2/HLA-F/HLA-DMB/HLA-DQA2/FAS/HLA-A/B2M/NFKBIA/CCL5/TNFRSF14/HLA-DOA/TLR2/PILRA/BIRC3/CARD9/HLA-C/IFNAR1/BST2/EIF2S1/SRSF5/EIF2B2/CHUK	3.53385578631768
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/973	31/9376	3.10844412027981	SRP14/SEC63/SRP54/SEC11C/SEC62/SEC61G/SGTA/SEC61A1/BAG6/SRP68	4.00108857793542
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	20/973	91/9376	2.11784104898185	LILRB4/NFKBIA/MAP2K2/JUN/CD72/LILRB1/LILRB2/LILRA2/NFKBIE/GRB2/PRKCB/FOS/NRAS/RAC1/RASGRP3/PTPN6/NFATC3/PPP3CB/SOS2/CHUK	3.64615118396683
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	22/973	105/9376	2.01900846669603	MDM2/FCER1G/RELB/LSP1/CALM2/NFKBIA/CALM1/PLK3/CASP1/JUN/CLEC1B/IL10/NRAS/MRAS/CARD9/PYCARD/NFKB2/NFATC3/PPP3CB/CHUK/CLEC7A/MAPK9	3.57300832444427
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	29/973	157/9376	1.77993074148506	CDKN1A/SQSTM1/GADD45A/MDM2/HLA-B/SERPINE1/HLA-F/HLA-A/CALM2/CDK4/GADD45B/CALM1/MAP2K2/VDAC2/NRAS/SMAD2/FOXO3/TGFBR1/MRAS/HLA-C/SLC25A4/CAPN2/IGFBP3/MAP2K3/HIPK1/RASSF5/NFATC3/PPP3CB/RAD9A	3.35342682426505
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	22/973	109/9376	1.94491641287232	SPP1/LY96/CD86/NFKBIA/CCL3/CCL5/MAP2K2/CXCL9/CXCL10/JUN/CD14/TLR2/FOS/IRF5/TLR4/RAC1/MAP2K4/IFNAR1/MAP2K3/CHUK/MAPK9/CD40	3.37646254620997
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	27/973	144/9376	1.80678314491264	PSMA7/NOP56/PSMD12/PSMB6/PSMD8/VDAC2/PPIF/PSMB5/PSMC4/PSMD7/PUM2/PLCB2/PSMD3/WIPI2/PSMD13/PRKCB/ATXN2/PSMB2/NRBF2/PSMA5/PSMB4/SLC25A4/ATXN1/ADRM1/MAPK9/SP1/GNAQ	3.31982385420544
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	26/973	138/9376	1.81551156590256	FN1/IL18/FCGR2A/CD4/NFKBIA/ACTR3/MAP2K2/ARPC1B/CASP1/JUN/LCP2/IL10/FOS/TLR4/RAC1/PKN1/CRK/MAP2K4/PYCARD/WAS/MAP2K3/SKAP2/NFATC3/CHUK/MAPK9/GNAQ	3.28401827751479
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	19/973	90/9376	2.03430398538312	CD4/NFKBIA/MAP2K2/CSNK2A1/JUN/TLR2/NFKBIE/FOS/NRAS/TLR4/RPS6KB2/BATF/PTPN6/MAP2K3/NFATC3/PPP3CB/HIF1A/CHUK/STAT3	3.35490316808467
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	25/973	133/9376	1.81131142347132	TYROBP/HLA-B/FCER1G/FCGR3A/ITGB2/FAS/HLA-A/CD48/MAP2K2/TNFRSF10B/ICAM2/LCP2/GRB2/PRKCB/LAT2/NRAS/RAC1/HCST/HLA-C/SH3BP2/IFNAR1/PTPN6/TNFRSF10A/PPP3CB/SOS2	3.20650418830871
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	29/973	163/9376	1.71441181848561	CDKN1A/BAX/DDB2/ATF4/FAS/NFKBIA/STAT6/MAP2K2/YWHAZ/DDX3X/JUN/MMP9/TLR2/GRB2/PRKCB/FOS/NRAS/TGFBR1/SMAD4/TLR4/CREB5/MAP2K4/IFNAR1/MAP2K3/NFATC3/SOS2/CHUK/STAT3/MAPK9	3.13088253249742
Organismal Systems	Digestive system	hsa04978	Mineral absorption	14/973	61/9376	2.21158155442859	HMOX1/FTL/FTH1/MT1M/MT1H/MT1X/MT1G/MT2A/MT1E/HMOX2/MT1F/ATOX1/SLC8A1/SLC31A1	3.23036069419477
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/973	88/9376	1.97103615808652	C1QA/SERPINE1/C1QB/ITGB2/SERPINA1/C1QC/C5AR1/C3AR1/VSIG4/CLU/A2M/ITGAX/ITGAM/CD46/CD59/F13A1/C2/PLAUR	3.11415705322749
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/973	21/9376	3.21205892428914	PPCS/PPCDC/DPYD/ALDH1B1/BCAT1/COASY/BCAT2	3.45310130359833
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	20/973	103/9376	1.87110228599367	SAP18/RBM8A/FUS/GSPT1/ETF1/RNMT/PPP2CA/NCBP2/TARDBP/PPP2R3C/EIF4A3/MAGOH/PAPOLA/UPF3A/SMG1/UPF2/CSTF1/CSTF3/CASC3/PELO	3.02484073153076
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/973	32/9376	2.71017471736896	GABARAPL1/GABARAP/PPP2CA/WIPI2/GABARAPL2/ATG12/ATG5/ATG4C/ATG4B	3.29741745471527
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/973	70/9376	2.0648950227573	CDKN1A/RBX1/MAP2K2/JUN/VEGFA/FLCN/GRB2/NRAS/RAP1B/RAC1/CRK/EPAS1/TFE3/SOS2/HIF1A	3.04298050227684
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	32/973	193/9376	1.59770806596766	CXCL16/CCL18/CXCR4/GNG5/PPBP/PF4/NFKBIA/CCL3/CCL5/CXCL9/CXCL10/FGR/HCK/DOCK2/PLCB2/GRB2/PRKCB/NRAS/FOXO3/RAP1B/GNB1/RAC1/GNB2/CXCL3/CXCL2/CRK/WAS/GNAI3/SOS2/CHUK/STAT3/GNAQ	2.85496215395179
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/973	77/9376	2.00232244631011	CDKN1A/GADD45A/BAX/DDB2/MDM2/CDK4/GADD45B/NFKBIA/MAP2K2/GRB2/NRAS/TGFBR1/SMAD4/CRK/SOS2/CHUK	3.00510444915074
Genetic Information Processing	Transcription	hsa03040	Spliceosome	38/973	243/9376	1.50689184102453	SYF2/SRSF3/RBM8A/TRA2B/FUS/SNRPE/SNRPA1/PRPF38B/THOC7/PRPF19/SF3A3/PUF60/PRPF4/HSPA1B/SF3A1/LSM7/NCBP2/THOC3/LSM3/SNRPG/EIF4A3/PRPF8/SF3B4/MAGOH/ISY1/CWC25/CTNNBL1/TRA2A/HNRNPK/CDC40/SNRPC/RBM22/SRSF5/PRPF31/DHX38/CHERP/CASC3/PQBP1	2.72418492535318
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	19/973	100/9376	1.83087358684481	CCL18/IL18/CXCR4/PPBP/PF4/TNFRSF10D/CCL3/CCL5/TNFRSF14/TNFRSF10B/CXCL9/CXCL10/TNFRSF10C/IL10/IL6R/CXCL3/CXCL2/TNFRSF10A/IL6ST	2.84236246693684
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/973	73/9376	1.98003632319194	CDKN1A/GADD45A/BAX/DDB2/CDK4/GADD45B/MAP2K2/KIF5B/GRB2/PRKCB/NRAS/FOXO3/RASSF5/SOS2/STAT3	2.86033544871771
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	23/973	130/9376	1.70486204443039	ATF4/GNG5/NFKBIA/MAP2K2/JUN/MMP9/VEGFA/PLCB2/GRB2/VEGFB/FOS/NRAS/SMAD2/TGFBR1/GNB1/GNB2/CREB5/GNA15/MAP2K4/GNAI3/SOS2/GNAS/MAPK9	2.75374507462084
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	27/973	160/9376	1.62610483042138	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-B/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DQB1/ITGB2/HLA-F/HLA-DMB/HLA-DQA2/CD86/HLA-A/ALCAM/CD4/PTPRC/MADCAM1/SELPLG/HLA-DOA/ITGAM/ICAM2/SDC2/SIGLEC1/HLA-C/CLDN5/CD40	2.71807032590724
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	32/973	200/9376	1.54178828365879	BAX/TUBA4A/TUBB1/FAS/IL18/FCGR2A/BRK1/NFKBIA/ACTR3/CYTH4/ARPC1B/NCKAP1L/TNFRSF10B/CASP1/MYO5A/TUBB4B/TUBA1A/JUN/FOS/TLR4/RAC1/CLDN5/LPAR5/ARF1/PYCARD/PTPN6/TMBIM6/TJP1/TNFRSF10A/MYO1F/CHUK/MAPK9	2.63537717984943
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	32/973	201/9376	1.53411769518287	CDKN1A/GADD45A/DDIT3/BAX/DDB2/MDM2/CD86/LYL1/SPI1/BCL2A1/FUS/GADD45B/CEBPB/FCGR1A/PTCRA/ITGAM/MMP9/JMJD1C/CD14/AFF1/BCL6/MAX/BIRC3/NR4A3/TFE3/IGFBP3/CCNT1/CCNT2/FLI1/KLF3/SP1/CD40	2.60469475244037
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/973	142/9376	1.62864959541421	UBA52/UBE2B/DDB2/UBB/UBC/MDM2/RBX1/SKP1/UBE2H/ANAPC16/RPS27A/PRPF19/CUL5/UBE2K/HERC4/UBE2D2/BIRC3/ANAPC13/UBE2F/PIAS1/CUL3/UBE2D3/SIAH1/UBE2Z	2.56851883068841
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/973	142/9376	1.62864959541421	SQSTM1/HMOX1/GSTP1/HSP90AB1/GSTO1/NCF2/CALM2/GSTT1/CALM1/SUMO3/JUN/MMP9/SUMO1/VEGFA/SDC2/DUSP1/FOS/RAC1/MAP2K4/GSTM3/CHUK/MAPK9/ITGA2B/TXN	2.56851883068841
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/973	37/9376	2.34393489069748	FAS/IL18/PLCB2/IL10/PRKCB/HBA1/HBB/GNAQ/HBA2	2.7871078849674
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/973	37/9376	2.34393489069748	CDKN1A/GADD45A/BAX/DDB2/GADD45B/MAP2K2/NCOA4/NRAS/TPM3	2.7871078849674
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	15/973	77/9376	1.87717729341573	CDKN1A/GADD45A/BAX/DDB2/CDK4/GADD45B/VEGFA/SMAD2/TGFBR1/SMAD4/RAC1/RPS6KB2/CHUK/STAT3/MAPK9	2.62990158191274
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	21/973	122/9376	1.65868616582144	ATF4/CSH1/MAP2K2/JUNB/PLCB2/GRB2/IRS2/PRKCB/FOS/NRAS/CREB5/CRK/MAP2K4/IGFBP3/MAP2K3/GNAI3/SOS2/GNAS/STAT3/MAPK9/GNAQ	2.49183101188496
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	23/973	139/9376	1.59447529335216	HSP90AB1/ATF4/CTSD/CALM2/CALM1/MAP2K2/KRT10/HBEGF/JUN/MMP9/HSPA1B/PLCB2/GRB2/FOS/NRAS/POMC/NCOA2/CREB5/GNAI3/SOS2/GNAS/SP1/GNAQ	2.4027058995622
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	37/973	250/9376	1.42615416238438	MDM2/HLA-B/HLA-F/HLA-A/CXCR4/ACTR3/ASAP1/CYTH4/VPS25/VPS35/ARPC1B/ARF5/SNX2/HSPA1B/RAB11A/KIF5B/CHMP3/SMAD2/AP2B1/TGFBR1/RAB11B/SNF8/RABEP1/RAB10/PARD6A/HLA-C/STAMBP/SPG21/RUFY1/ARF1/ARFGAP2/RAB7A/STAM/VPS26B/RAB4A/PRKCI/FOLR2	2.32392112268831
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/973	59/9376	1.9599003605832	GPX1/GSTP1/ODC1/GSTO1/GPX4/GPX3/GSTT1/PRDX6/PGD/G6PD/GSTM3/RRM2B	2.51674369600812
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/973	33/9376	2.33604285402847	VAMP5/STX18/STX5/STX11/VAMP2/STX7/STX3/GOSR1	2.61612843111713
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	43/973	300/9376	1.38118533744433	GADD45A/DDIT3/JUND/ATF4/FAS/IGF2/RELB/GADD45B/HSPB1/MAP2K2/DUSP8/JUN/CD14/HSPA1B/VEGFA/GRB2/PRKCB/DUSP1/VEGFB/FOS/DUSP3/NRAS/MAX/TGFBR1/MAP3K13/EREG/RAP1B/MRAS/RAC1/CRK/MAP2K4/MAPKAPK3/RASGRP3/NFKB2/MAP2K3/INSR/TAOK3/NFATC3/PPP3CB/SOS2/CHUK/MAPK9/MAPKAPK5	2.28336030690126
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/973	110/9376	1.66443053349528	CDKN1A/HMOX1/RBX1/SERPINE1/TIMP1/ALDOA/MAP2K2/EIF4E2/HK3/VEGFA/PRKCB/IL6R/TLR4/RPS6KB2/EPAS1/CYBB/INSR/HIF1A/STAT3	2.38519918995125
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/973	103/9376	1.68399205739431	FN1/PRDX1/ITGB2/ARG2/HSPB1/ITGAM/CD14/TLR2/PLCB2/IL10/PRKCB/TLR4/CXCL3/GNA15/CXCL2/RAB7A/GNAS/GNAQ	2.3751137708125
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/973	119/9376	1.61952550804494	ATF4/FAS/CEBPB/NFKBIA/CCL5/LIF/CXCL10/JUN/MMP9/JUNB/FOS/RHBDF2/BIRC3/CXCL3/CREB5/CXCL2/MAP2K4/MAP2K3/CHUK/MAPK9	2.31431472135554
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/973	105/9376	1.65191601820584	GADD45A/LY96/RELB/BCL2A1/TNFSF13B/GADD45B/NFKBIA/EDA2R/CSNK2A1/CD14/PRKCB/TLR4/BIRC3/CXCL3/CXCL2/NFKB2/CHUK/CD40	2.28585084031776
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/973	98/9376	1.67158168508925	FCGR3A/GSN/FCGR2A/PTPRC/ACTR3/ASAP1/FCGR1A/ARPC1B/HCK/PRKCB/MARCKS/RAC1/RPS6KB2/CRK/LIMK2/WAS/CFL2	2.27410008363648
Human Diseases	Cancer: specific types	hsa05214	Glioma	14/973	76/9376	1.77508519500189	CDKN1A/GADD45A/BAX/DDB2/MDM2/CALM2/CDK4/GADD45B/CALM1/MAP2K2/GRB2/PRKCB/NRAS/SOS2	2.30855188532086
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	23/973	144/9376	1.53911156788855	C1QA/C1QB/LY96/FAS/C1QC/TRA2B/C5AR1/C3AR1/NFKBIA/CD14/ADIPOR1/ADIPOR2/FOXO3/TLR4/CXCL3/TRA2A/CXCL2/MAP2K4/C2/MAP2K3/ALDH1B1/CHUK/MAPK9	2.21838477221569
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	20/973	122/9376	1.57970111030613	CD4/PTPRC/CDK4/NFKBIA/MAP2K2/JUN/PPP2CA/LCP2/NFKBIE/IL10/GRB2/PPP2R3C/FOS/NRAS/PTPN6/NFATC3/PPP3CB/SOS2/CHUK/MAPK9	2.19302799912843
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/973	138/9376	1.53620209422524	MT-ND2/COX6A1/COX6B1/UQCR10/COX4I1/NDUFS3/NDUFA5/NDUFB10/ATP6V0E1/UQCRQ/ATP6V0B/NDUFA12/COX7A2/SDHA/NDUFA2/NDUFB3/COX8A/NDUFB4/MT-ND4/NDUFA6/NDUFA11/COX15	2.1592550633277
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	26/973	170/9376	1.4737682123209	CDKN1A/HMOX1/GADD45A/BAX/DDB2/GSTP1/GSTO1/IGF2/GSTT1/CDK4/GADD45B/MAP2K2/FRAT1/TXNRD1/GRB2/PRKCB/NRAS/SMAD2/TGFBR1/SMAD4/FRAT2/CSNK1A1/RPS6KB2/PHF10/GSTM3/SOS2	2.12119097255942
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	34/973	235/9376	1.39417025649997	MT-ND2/COX6A1/COX14/COX6B1/UQCR10/COX4I1/NDUFS3/NDUFA5/NDUFAF4/NDUFB10/UQCRQ/NDUFA12/COX7A2/SDHA/NDUFA2/GRB2/NDUFB3/NRAS/COA4/COX8A/COX20/NDUFB4/CREB5/RPS6KB2/MT-ND4/PNPLA2/NDUFAF3/MAP2K3/ACSL1/SOS2/NDUFA6/NDUFA11/GNAS/COX15	2.08231200623434
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/973	93/9376	1.65783686414923	ATF4/CALM2/CALM1/MAP2K2/HBEGF/JUN/PLCB2/GRB2/PRKCB/NRAS/MAP2K4/MAP2K3/SOS2/GNAS/MAPK9/GNAQ	2.16940373046061
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/973	71/9376	1.76437039503206	NFKBIA/ATP6V0E1/CCL5/ATP6V0B/HBEGF/JUN/RAC1/CXCL3/CXCL2/MAP2K4/TJP1/CHUK/MAPK9	2.19988369153784
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/973	101/9376	1.62193074394798	BAX/FN1/SERPINE1/CDK4/JUN/VEGFA/PLCB2/PRKCB/VEGFB/NRAS/SMAD2/TGFBR1/SMAD4/RAC1/CYBB/STAT3/MAPK9	2.13830981875467
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/973	50/9376	1.92723535457348	AOC1/ODC1/SAT1/ARG2/SAT2/AMD1/SMOX/GOT1/PYCR1/ALDH1B1	2.23692877250031
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/973	50/9376	1.92723535457348	ITGB2/IL18/TLR2/IL10/SDC2/HBA1/TLR4/HBB/CD40/HBA2	2.23692877250031
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/973	157/9376	1.47304613088419	C1QA/ODC1/C1QB/C1QC/HAVCR2/ARG2/CEBPB/MAP2K2/SIRPA/ABCA1/CASP1/DUSP8/PTGER4/IL10/ALOX5/RAC1/CRK/RAB7A/PTPN6/NFATC3/HIF1A/VPS33A/VPS8/LIPA	2.0339313480596
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/973	59/9376	1.7965753305346	CDKN1A/GADD45A/BAX/DDB2/GADD45B/MAP2K2/GRB2/ILK/NRAS/FOXO3/SOS2	2.08852504264142
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/973	52/9376	1.85311091785912	APOE/APOC1/CYP27A1/LPL/VDAC2/ABCA1/APOC2/VAPB/LRPAP1/LIPA	2.09908930519557
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/973	250/9376	1.34906474820144	BLOC1S2/SLC11A1/LAPTM5/CTSS/CD68/CTSD/RRAGD/ATP6V0E1/PSAP/VPS35/IDS/ACP5/ATP6V0B/CTSB/SNAPIN/CTSZ/M6PR/LGMN/CTSH/LAMTOR4/AP2B1/KXD1/BLOC1S4/RAB7A/TFE3/VPS26B/RRAGA/GM2A/ARL8B/NEU1/DMXL2/AP1S2/CTSC/VPS33A/LIPA	1.90353400983451
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/973	90/9376	1.60602946214457	BAX/ATF4/SESN1/EIF4E2/SESN2/ADIPOR1/SOD2/IRS2/ADIPOR2/NRAS/FOXO3/CREB5/RPS6KB2/ATG5/INSR	1.96573753097195
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/973	68/9376	1.70050178344719	SPI1/BCL2A1/MAP2K2/FCGR1A/ITGAM/CD14/GRB2/NRAS/RPS6KB2/SOS2/CHUK/STAT3	1.97269703091576
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/973	76/9376	1.6482933953589	UBC/CYP27A1/PLIN2/LPL/FABP4/ACAA1/ILK/OLR1/SLC27A5/DBI/FABP3/ACSL1/ME1	1.93090895007122
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	16/973	99/9376	1.55736190268564	CDKN1A/BAX/MDM2/CDK4/MAP2K2/HBEGF/JUN/MMP9/GRB2/FOS/NRAS/RPS6KB2/SOS2/GNAS/MAPK9/SP1	1.89703776076063
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/973	69/9376	1.6758568300639	FCER1G/ALOX5AP/MAP2K2/LCP2/GRB2/ALOX5/NRAS/RAC1/MAP2K4/MAP2K3/SOS2/MAPK9	1.9173406149712
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/973	62/9376	1.7096442661539	SOD1/EIF4EBP2/HSPA1B/SOD2/IRS2/NRAS/FOXO3/RPS6KB2/ATG5/CRYAB/INSR	1.90762630553813
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/973	34/9376	1.98391874735506	POLR2B/CRCP/POLR2E/POLR3GL/POLR2D/POLR1C/POLR2J3	1.95570631993951
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/973	41/9376	1.88022961421803	CDKN1A/MDM2/CDK4/MAP2K2/HBEGF/MMP9/VEGFA/NRAS	1.92200989653254
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	24/973	168/9376	1.3765966818382	SQSTM1/FTL/FTH1/BAX/GLUL/HSP90AB1/FAS/STAT6/VDAC2/TNFRSF10B/CASP1/CHMP3/TLR4/BIRC3/IFNAR1/CYBB/PYCARD/SLC25A4/SHARPIN/CAPN2/SPATA2L/TNFRSF10A/STAT3/MAPK9	1.67599744134096
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/973	120/9376	1.44542651593011	BAX/ATF4/CALM2/NFKBIA/CALM1/MAP2K2/JUN/NFKBIE/GRB2/NRAS/FOXO3/RAP1B/ARHGDIA/RAC1/MATK/CRK/SOS2/MAPK9	1.67101324908645
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	27/973	195/9376	1.33423986085857	FCGR3A/ITGB2/NCF2/FPR3/FCGR2A/C5AR1/MAP2K2/FCGR1A/SELPLG/VDAC2/SIGLEC9/PPIF/CASP1/ITGAM/FPR1/TLR2/PLCB2/AQP9/PRKCB/HDAC3/TLR4/RAC1/NCF4/CYBB/SLC25A4/CLEC7A/ITGA2B	1.60492754344556
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	29/973	212/9376	1.31815625666583	ITGB2/CALM2/CALM1/MAP2K2/ITGAM/FPR1/VEGFA/PLCB2/LCP2/DOCK4/PRKCB/VEGFB/NRAS/RAP1B/MRAS/RAC1/APBB1IP/PARD6A/CRK/LPAR5/RASGRP3/MAP2K3/GNAI3/INSR/RASSF5/GNAS/PRKCI/ITGA2B/GNAQ	1.59437595098172
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/973	89/9376	1.51580308786679	TUBA4A/TUBB1/MAP2K2/TUBB4B/TUBA1A/PLCB2/GRB2/PRKCB/NRAS/GNAI3/TJP1/SOS2/GNAS/GNAQ	1.66366582270944
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/973	51/9376	1.70050178344719	ATP6V0E1/ATP6V0B/KDELR2/SEC61G/SEC61A1/ARF1/TJP1/GNAS/TJP2	1.706847772426
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/973	75/9376	1.54178828365879	GLUL/SDS/ARG2/ALDOA/MAT2A/PGAM1/TPI1/GOT1/IDH3B/PYCR1/BCAT1/BCAT2	1.60295117842477
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/973	75/9376	1.54178828365879	CDKN1A/BBC3/BAX/MDM2/GSTP1/GSTO1/FAS/GSTT1/BIRC3/GSTM3/PMAIP1/SLC31A1	1.60295117842477
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/973	115/9376	1.42447830555431	CDKN1A/NACA/JUND/ATF4/MAFB/PDE4C/NR4A2/HBEGF/PLCB2/PRKCB/FOS/CREB5/PDE4A/GNAI3/GNAS/SP1/GNAQ	1.55847684320545
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/973	83/9376	1.50928069936478	IL18/NFKBIA/CCL5/CASP1/CXCL10/IFI16/SAMHD1/POLR2E/POLR3GL/PYCARD/CHUK/POLR1C/ADAR	1.58578086046819
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/973	140/9376	1.3765966818382	SPP1/MAP1LC3B/SERPINE1/CALM2/GNG5/CALM1/MAP2K2/PLCB2/MAP1LC3B2/NRAS/SMAD2/TGFBR1/SMAD4/MRAS/GNB1/GNB2/SLC8A1/RPS6KB2/GNAI3/GNAQ	1.52764844189587
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	17/973	116/9376	1.4121983201616	SDS/FBP1/ALDOA/PGLS/PGAM1/ECHS1/HK3/SDHA/ME2/PCCA/TPI1/GOT1/PGD/IDH3B/G6PD/ME1/ADPGK	1.52003852578449
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/973	17/9376	2.26733571126292	CYP27A1/HSD3B7/SLC27A5/ACOT8	1.77961593686912
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/973	143/9376	1.34771703117027	HLA-DRA/HLA-DRB1/HLA-DPA1/C1QA/HLA-DQA1/HLA-DPB1/FCGR3A/HLA-DMA/HLA-DQB1/C1QB/HLA-DMB/HLA-DQA2/CD86/C1QC/FCGR2A/FCGR1A/HLA-DOA/IL10/C2/CD40	1.42576332931357
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/973	54/9376	1.60602946214457	SDS/MAT2A/TST/AMD1/IL4I1/AHCYL1/GOT1/BCAT1/BCAT2	1.51971078339215
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	14/973	94/9376	1.43517526404408	JUND/HSP90AB1/CEBPB/NFKBIA/CXCL10/JUN/MMP9/FOS/FOSL1/CXCL3/CXCL2/CHUK/MAPK9/S100A8	1.44288667527223
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/973	70/9376	1.51425635002202	NFKBIA/ADIPOR1/NFKBIE/IRS2/ADIPOR2/G6PC3/POMC/ACSL1/CHUK/STAT3/MAPK9	1.469508273442
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/973	86/9376	1.45663137264275	CDKN1A/MAP2K2/HBEGF/JUN/GRB2/PRKCB/NRAS/EREG/RPS6KB2/CRK/MAP2K4/SOS2/MAPK9	1.44754472599098
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/973	78/9376	1.4824887342873	BTG2/TOB1/BTG3/DCP1B/LSM7/HSPA9/LSM3/EXOSC6/DDX6/BTG1/XRN1/DCP1A	1.45601075971987
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/973	136/9376	1.34623057856236	BBC3/BAX/FAS/CDK4/NFKBIA/CSNK2A1/JUN/HSPA1B/TLR2/CD46/FOS/TLR4/IFNAR1/EIF2S1/MX2/CHUK/STAT3/MAPK9/ADAR	1.38396072824864
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/973	204/9376	1.27537633758539	CDKN1A/FN1/TIMP3/MDM2/CD44/FAS/IGF2/MAP2K2/HBEGF/MMP9/TLR2/VEGFA/SDC2/GRB2/PRKCB/NRAS/SMAD2/PDCD4/TLR4/MRAS/RAC1/RPS6KB2/PLAUR/PTPN6/SOS2/HIF1A/STAT3	1.3531145278334
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/973	63/9376	1.52955186870911	DDB2/RBX1/POLD4/POLR2B/GTF2H3/XPC/POLR2E/RAD23A/POLR2D/POLR2J3	1.43502297659363
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/973	48/9376	1.60602946214457	HADHB/ECHS1/ACAA1/IL4I1/PCCA/ALDH1B1/BCAT1/BCAT2	1.43233618781599
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/973	80/9376	1.44542651593011	BAX/MAP2K2/EIF4E2/VEGFA/GRB2/PRKCB/NRAS/IL6R/FOXO3/RPS6KB2/SOS2/STAT3	1.36143803426781
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/973	99/9376	1.36269166484994	MAP2K2/JUN/GRB2/PRKCB/FOS/NRAS/DGKE/RAC1/RPS6KB2/WAS/SOS2/HIF1A/MAPK9/SP1	1.23445786376528
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/973	133/9376	1.30414422489935	ATF4/CALM2/GNG5/CALM1/PPP2CA/KIF5B/PLCB2/PPP2R3C/PRKCB/FOS/GNB1/GNB2/CREB5/GNAI3/PPP3CB/GNAS/MAPK9/GNAQ	1.20205349361033
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	15/973	108/9376	1.33835788512047	SAP18/RBM8A/THOC7/SUMO3/SEC13/SUMO1/NCBP2/THOC3/POM121/EIF4A3/MAGOH/UPF3A/POM121C/UPF2/CASC3	1.2034278103916
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/973	67/9376	1.43823533923394	ATF4/CALM2/CALM1/MAP2K2/PLCB2/PRKCB/NRAS/RAP1B/PPP3CB/GNAQ	1.22494942688703
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/973	205/9376	1.22214924924172	CDKN1A/BAX/MDM2/HLA-B/ATF4/HLA-F/GSN/HLA-A/CDK4/NFKBIA/YWHAZ/DDX3X/JUN/GTF2H3/GRB2/HDAC3/NRAS/RAC1/GTF2A1/CREB5/HNRNPK/HLA-C/NFKB2/PMAIP1/IL6ST/STAT3	1.09430481523606
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/973	93/9376	1.34699245212125	CDKN1A/GADD45A/BAX/FN1/DDB2/CDK4/GADD45B/NFKBIA/MAX/CKS2/BIRC3/CHUK/ITGA2B	1.14430607510428
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/973	69/9376	1.39654735838658	CALM2/CALM1/CTSB/PLCB2/PTGER4/KCNMA1/GNAI3/PPP3CB/GNAS/GNAQ	1.12496659377142
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	16/973	122/9376	1.26376088824491	FBP1/ADIPOR1/PPP2CA/IRS2/RAB2A/PPP2R3C/ADIPOR2/FOXO3/RAB11B/G6PC3/RAB10/EEF2/CREB5/RPS6KB2/HMGCR/INSR	0.997815948102292
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/973	15/9376	1.92723535457348	ACP1/NTPCR/AK1	1.22292371224687
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	19/973	149/9376	1.22877421935893	MT-ND2/GNG5/NDUFS3/NDUFA5/NDUFB10/NDUFA12/PLCB2/NDUFA2/PRKCB/NDUFB3/GNB1/GNB2/NDUFB4/MT-ND4/GNAI3/NDUFA6/NDUFA11/MAPK9/GNAQ	0.957844109001671
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/973	106/9376	1.27270259264287	CDKN1A/MDM2/GSTP1/HSP90AB1/ATF4/NFKBIA/MAP2K2/MMP9/GRB2/NRAS/CREB5/SOS2/CHUK/FOLR2	0.960787200954044
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/973	31/9376	1.55422206013991	FBP1/ALDOA/PGLS/PGD/G6PD	1.05171938546388
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/973	73/9376	1.32002421546129	SUPT4H1/CXCR4/CD4/MDFIC/SAMHD1/BST2/MX2/CCNT1/CCNT2/SERINC3	0.934023144112314
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/973	125/9376	1.23343062692703	BAX/FCER1G/CTSD/MAP2K2/PPP2CA/PLCB2/PPP2R3C/PRKCB/NRAS/ORMDL1/RAC1/GNAI3/SPTSSA/MAPK9/GNAQ/CERS2	0.894012063405376
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/973	32/9376	1.50565262076053	BBC3/BAX/BIRC3/PMAIP1/MAPK9	0.974957564735524
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/973	83/9376	1.27708366869327	SKP1/PHF1/ASXL1/UBE2D2/MAX/CBX7/KDM2A/EED/RNF2/UBE2D3/OGT	0.86277367100335
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	35/973	298/9376	1.13176572835691	GDF15/CXCL16/FAS/CCL18/IL18/CSH1/CXCR4/CD4/TNFSF13B/PPBP/PF4/EDA2R/TNFRSF10D/CCL3/CCL5/TNFRSF14/LIF/TNFRSF10B/CXCL9/CXCL10/TNFRSF10C/IL1RN/TNFRSF12A/IL10/AMHR2/IL6R/TGFBR1/IL4R/CXCL3/CXCL2/IFNAR1/TNFSF9/TNFRSF10A/IL6ST/CD40	0.786575448166036
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	19/973	154/9376	1.18887895249663	MAT2A/PPCS/AFMID/RFK/AK1/PPCDC/AKR1A1/LIPT1/GGCX/GMPPA/LIAS/ALDH1B1/BCAT1/COX15/COASY/COQ4/MTHFD2/BCAT2/FLAD1	0.804185509896785
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/973	67/9376	1.29441180531055	FBP1/ALDOA/PGAM1/HK3/TPI1/G6PC3/AKR1A1/ALDH1B1/ADPGK	0.8229358518059
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/973	138/9376	1.1870652546286	FBP1/CALM2/CALM1/MAP2K2/EIF4E2/HK3/FLOT1/GRB2/IRS2/NRAS/G6PC3/RPS6KB2/CRK/INSR/SOS2/PRKCI/MAPK9	0.753301045593839
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/973	156/9376	1.17363691464411	CDKN1A/BAX/FAS/CDK4/NFKBIA/MAP2K2/YWHAZ/CXCL10/PPP2CA/GRB2/NRAS/CLDN5/IFNAR1/PIAS1/EIF2S1/MX2/SOS2/CHUK/STAT3	0.744155636260167
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	18/973	148/9376	1.17196744534874	CDKN1A/GADD45A/BAX/DDB2/CDK4/GADD45B/MAP2K2/FRAT1/JUN/GRB2/FOS/NRAS/FRAT2/CSNK1A1/RPS6KB2/NFKB2/SOS2/SP1	0.717543411369643
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/973	34/9376	1.41708481953933	RBX1/SKP1/NR1D1/NR1D2/FBXL3	0.829027213595251
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/973	10/9376	1.92723535457348	TST/PAPSS2	0.998246468198322
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/973	60/9376	1.28482356971566	HSPB1/MAP2K2/VEGFA/PRKCB/NRAS/RAC1/MAPKAPK3/PPP3CB	0.75311567518381
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/973	60/9376	1.28482356971566	MAP2K2/PPP2CA/PLCB2/PRKCB/NRAS/GNAI3/GNAS/GNAQ	0.75311567518381
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	19/973	158/9376	1.1587807511676	CDKN1A/GADD45A/MDM2/RBX1/SKP1/CDK4/GADD45B/ANAPC16/YWHAZ/CDKN2D/PPP2CA/NIPBL/WEE1/MAD2L2/SMAD2/SMAD4/ORC3/ANAPC13/ORC4	0.684909074556209
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/973	69/9376	1.25689262254792	ATF4/CALM2/CALM1/JUN/PRKCB/FOS/CREB5/PPP3CB/GNAS	0.728779583171533
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/973	87/9376	1.21836717817864	COX6A1/COX6B1/UQCR10/COX4I1/TNNI3/UQCRQ/COX7A2/COX8A/SLC8A1/TPM3/ASPH	0.696285551747702
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/973	35/9376	1.3765966818382	FBP1/ALDOA/HK3/TPI1/GMPPA	0.759519103690341
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/973	44/9376	1.31402410539101	GTF2H3/GTF2F1/GTF2A1/TAF3/TAF7/TAF9	0.710439069509215
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/973	53/9376	1.27270259264287	RAB11A/PLCB2/PRKCB/AP2B1/SLC8A1/GNAS/GNAQ	0.677445303253894
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/973	170/9376	1.13366785563146	TUBA4A/MYL6/CDK4/ACTR3/HSPA4/ARPC1B/TUBA1A/JUN/PPP2CA/RAC1/PARD6A/CLDN5/MYL12B/WAS/YBX3/TJP1/RAB8B/PRKCI/MAPK9/TJP2	0.598467861104162
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/973	19/9376	1.52150159571591	ACSM1/LIPT1/LIAS	0.774263887795874
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/973	116/9376	1.16298685189779	ITGB2/NCF2/CXCR4/ITGAM/MMP9/PRKCB/RAP1B/RAC1/CLDN5/MYL12B/NCF4/CYBB/GNAI3/RASSF5	0.601036641740422
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/973	107/9376	1.17075044903997	ATF4/FBP1/CALM2/CALM1/PGAM1/PRMT1/PLCB2/G6PC3/CREB5/PPP4C/PPP3CB/GNAS/GNAQ	0.604452500886914
Organismal Systems	Immune system	hsa04611	Platelet activation	15/973	126/9376	1.14716390153184	FCER1G/FCGR2A/FERMT3/PLCB2/LCP2/GP9/RAP1B/APBB1IP/MYL12B/TBXAS1/GNAI3/GNAS/PRKCI/ITGA2B/GNAQ	0.565901149164938
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/973	72/9376	1.20452209660843	NFKBIA/ISG15/DDX3X/CXCL10/ATG12/ATG5/CHUK/MAPK9/ADAR	0.592784050631629
NA	NA	hsa04518	Integrin signaling	18/973	154/9376	1.12630637604944	SPP1/FN1/ITGB2/PARVG/MADCAM1/FERMT3/ITGAX/ITGAM/ICAM2/VEGFA/ILK/FBN1/VEGFB/ICAM4/LIMS1/RAC1/PARVB/ITGA2B	0.537771710843988
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/973	37/9376	1.30218605038749	HK3/NAGK/GMPPA/NANS/GALK1	0.62668595747598
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/973	109/9376	1.14926878942455	TRIB3/NFKBIA/IRS2/PRKCB/MLXIP/G6PC3/SLC27A5/CREB5/RPS6KB2/INSR/STAT3/MAPK9/OGT	0.533381016505014
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/973	46/9376	1.25689262254792	HMOX1/FTL/FTH1/BLVRA/HMOX2/COX15	0.594312141666911
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/973	20/9376	1.44542651593011	NPL/GMPPA/NANS	0.678532781906469
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/973	73/9376	1.18802179391516	CDKN1A/GADD45A/BAX/DDB2/MDM2/CDK4/GADD45B/MAP2K2/NRAS	0.548760683191234
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/973	110/9376	1.13882089133888	EMP3/RBX1/SKP1/HAMP/TGIF1/PPP2CA/AMHR2/FBN1/SMAD2/TGFBR1/SMAD4/RPS6KB2/SP1	0.49834476424186
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/973	12/9376	1.60602946214457	GGCX/COQ4	0.714790110195213
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/973	12/9376	1.60602946214457	CD46/ASGR1	0.714790110195213
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	40/973	362/9376	1.064770914129	CDKN1A/SPP1/FN1/MDM2/HSP90AB1/ATF4/DDIT4/IGF2/CSH1/GNG5/CDK4/MAP2K2/MCL1/YWHAZ/EIF4E2/PPP2CA/TLR2/VEGFA/GRB2/PPP2R3C/VEGFB/NRAS/IL6R/FOXO3/EREG/IL4R/TLR4/G6PC3/GNB1/RAC1/GNB2/CREB5/PKN1/RPS6KB2/IFNAR1/LPAR5/INSR/SOS2/CHUK/ITGA2B	0.427661752568171
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/973	93/9376	1.1397628441026	ACP1/CSNK2A1/TGFBR1/SMAD4/RAP1B/RAC1/MYL12B/WAS/PTPN6/INSR/TJP1	0.460907638200065
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	18/973	158/9376	1.09779229057983	SLC3A2/DDIT4/RRAGD/MAP2K2/EIF4E2/SEC13/SESN2/FLCN/GRB2/PRKCB/NRAS/LAMTOR4/RPS6KB2/INSR/RRAGA/SOS2/CHUK/PRR5	0.421832160052358
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/973	75/9376	1.15634121274409	GPX1/ATF4/GPX3/PLCB2/ASGR1/PRKCB/CREB5/GNAS/GNAQ	0.462555833640596
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	20/973	178/9376	1.08271649133342	RBX1/SKP1/FRAT1/CSNK2A1/JUN/PLCB2/PRKCB/MMP7/SMAD4/TBL1XR1/FRAT2/CSNK1A1/FOSL1/RAC1/NFATC3/PPP3CB/CACYBP/SIAH1/CBY1/MAPK9	0.379123128383542
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/973	31/9376	1.24337764811193	ECHS1/SMOX/DPYD/ALDH1B1	0.461845546969572
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/973	97/9376	1.09276231444888	CALM2/GNG5/CALM1/PLCB2/PRKCB/FOS/GNB1/GNB2/GNAI3/GNAS/GNAQ	0.312486839951965
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/973	154/9376	1.06373379960225	CDKN1A/MYL6/CALM2/RGS2/CALM1/MAP2K2/JUN/PLCB2/PRKCB/FOS/NRAS/EEF2/GNAI3/NFATC3/PPP3CB/GNAS/GNAQ	0.271357911791191
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/973	23/9376	1.25689262254792	GLUL/ARG2/GOT1	0.419725117885369
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/973	42/9376	1.14716390153184	AOC1/ECHS1/AFMID/IL4I1/ALDH1B1	0.325249708935085
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/973	89/9376	1.08271649133342	GLUL/GABARAPL1/SLC38A2/GNG5/GABARAP/PRKCB/GABARAPL2/GNB1/GNB2/GNAI3	0.26679289605453
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/973	33/9376	1.16802142701423	GOT1/IDH3B/BCAT1/BCAT2	0.329005638496862
Cellular Processes	Cell motility	hsa04814	Motor proteins	21/973	194/9376	1.04309130015575	TUBA4A/TUBB1/MYL6/KIF2A/TNNI3/MYO5A/TUBB4B/TUBA1A/KIF5B/DYNC1LI1/DYNC1LI2/ACTR10/DYNLL2/TPM3/MYL12B/DYNC1H1/DCTN4/MYO1F/DCTN5/KIFC3/DCTN2	0.206370062255486
NA	NA	hsa04517	IgSF CAM signaling	32/973	299/9376	1.03129651080855	TUBA4A/TUBB1/CD84/ITGB2/MYL6/CD86/CD48/ACTR3/MAP2K2/ARPC1B/ITGAX/TUBB4B/TUBA1A/ITGAM/DOK2/ICAM2/LCP2/GRB2/PRKCB/SLAMF7/RAP1B/RAC1/DYNLL2/NRP2/PARD6A/MYL12B/PTPN6/TJP1/CASK/PRKCI/MAPK9/TJP2	0.187148014760188
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/973	71/9376	1.08576639694281	MAP2K2/GRB2/FOS/NRAS/FOXO3/SOS2/STAT3/MAPK9	0.246838573475271
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/973	166/9376	1.04488663802177	ATF4/CALM2/RGS2/CALM1/MAP2K2/VDAC2/PPIF/PLCB2/IRS2/KCNMA1/CREB5/SLC8A1/SLC25A4/GNAI3/INSR/NFATC3/PPP3CB/GNAQ	0.198548304948725
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/973	43/9376	1.12048567126365	HADHB/ECHS1/ACAA1/ACSL1/ALDH1B1	0.269453527236163
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/973	150/9376	1.02785885577252	CDKN1A/GADD45A/BAX/DDB2/GADD45B/MAP2K2/FRAT1/GRB2/NRAS/SMAD2/TGFBR1/SMAD4/FRAT2/CSNK1A1/RPS6KB2/SOS2	0.117038044244437
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	35/973	333/9376	1.0128113725236	CDKN1A/SPP1/BAX/FN1/MDM2/HLA-B/HLA-F/FAS/HLA-A/CDK4/ISG15/ATP6V0E1/MAP2K2/ATP6V0B/LFNG/PPP2CA/VEGFA/PTGER4/GRB2/PPP2R3C/NRAS/CSNK1A1/CREB5/RPS6KB2/PARD6A/HLA-C/IFNAR1/MX2/MFNG/SOS2/CHUK/GNAS/PRKCI/HES2/ITGA2B	0.081000255260924
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/973	93/9376	1.03614804009327	LYZ/CALM2/CALM1/PLCB2/KCNMA1/PRKCB/VAMP2/GNAS/CST3/GNAQ	0.119208419747957
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/973	16/9376	1.20452209660843	IL4I1/GOT1	0.278603892377654
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/973	65/9376	1.03774211400111	ATF4/PLCB2/POMC/CREB5/GNAS/SP1/GNAQ	0.103898580391363
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/973	85/9376	1.02030107006832	ITPA/NTPCR/NT5M/HPRT1/NT5C/AK1/GUK1/PNP/RRM2B	0.0639767301511526
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/973	115/9376	1.00551409803834	ATF4/GNG5/PLCB2/PRKCB/FOS/NRAS/GNB1/GNB2/CREB5/ACHE/GNAI3/GNAQ	0.0202450725784317
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/973	17/9376	1.13366785563146	TXNRD1/PAPSS2	0.187698842552003
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/973	203/9376	0.99684587305525	SPP1/FN1/PARVG/EMP2/JUN/VEGFA/GRB2/ILK/PRKCB/VEGFB/RAP1B/BIRC3/RAC1/CRK/MYL12B/CAPN2/EMP1/PARVB/SOS2/MAPK9/ITGA2B	-0.0154595328784698
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/973	86/9376	1.00843710413729	ATF4/PLCB2/KCNMA1/PRKCB/CCK/VAMP2/CREB5/GNAS/GNAQ	0.0267460501583258
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/973	27/9376	1.07068630809638	ACSM3/ECHS1/ACSM1	0.125158248842185
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/973	116/9376	0.99684587305525	GLUL/SLC38A2/GNG5/PLCB2/HOMER3/PRKCB/GNB1/GNB2/GNAI3/PPP3CB/GNAS/GNAQ	-0.01163128095562
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/973	38/9376	1.01433439714394	HK3/NAGK/GMPPA/GALK1	0.0301279216175024
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/973	98/9376	0.983283344170145	ATF4/CALM2/CALM1/NR4A2/PLCB2/PRKCB/POMC/CREB5/GNAS/GNAQ	-0.0566056955763229
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/973	128/9376	0.978674203494347	PDE4C/ITPA/NTPCR/NT5M/HPRT1/NT5C/HDDC3/AK1/GUK1/PNP/PDE4A/PAPSS2/RRM2B	-0.0826630093285456
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/973	217/9376	0.97693958065937	HSP90AB1/ATF4/GSTO1/GSTT1/MAP2K2/JUN/VEGFA/BCL6/GRB2/PRKCB/FOS/NRAS/AHR/KLF4/CREB5/RPS6KB2/MIR29A/GNAI3/GSTM3/SOS2/GNAS/STAT3	-0.116949377479745
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/973	168/9376	0.97508931630206	CDKN1A/CSH1/STAT6/MCL1/LIF/PTPN2/IL10/GRB2/IL6R/IL4R/IFNAR1/PIAS1/PTPN6/STAM/SOS2/IL6ST/STAT3	-0.110861949011378
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/973	59/9376	0.979950180291602	FABP4/IRS2/PNPLA2/GNAI3/INSR/GNAS	-0.052568224192094
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/973	49/9376	0.983283344170145	ATF4/JUN/CREB5/GNAI3/GNAS	-0.0399209924344159
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/973	99/9376	0.973351189178527	CALM2/CALM1/PLCB2/TRPV2/PTGER4/PRKCB/MAP2K3/GNAS/MAPK9/GNAQ	-0.0907019302254197
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/973	29/9376	0.99684587305525	CALM2/CALM1/GNB1	-0.005788511795981
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/973	101/9376	0.954076908204695	CALM2/CALM1/MAP2K2/PLCB2/PRKCB/NRAS/POMC/GNAI3/GNAS/GNAQ	-0.157891853794071
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/973	30/9376	0.963617677286742	PIGC/PIGH/MPPE1	-0.0679145828273151
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/973	30/9376	0.963617677286742	ABCC3/CHUK/FOLR2	-0.0679145828273151
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/973	102/9376	0.944723213026218	PLA2G12A/RAB11A/PLCB2/KCNMA1/PRKCB/CCK/RAP1B/RAC1/GNAS/GNAQ	-0.191000369714744
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/973	82/9376	0.940114807109017	GSTP1/GSTO1/GSTT1/ITPA/HPRT1/DPYD/GSTM3/RRM2B	-0.185331790475529
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/973	62/9376	0.932533236083944	PTCRA/LFNG/PSENEN/CIR1/ATXN1/MFNG	-0.181360407931329
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/973	31/9376	0.932533236083944	GLUL/AFMID/PCCA	-0.128028291524735
NA	NA	hsa04981	Folate transport and metabolism	3/973	31/9376	0.932533236083944	ABCC3/SLCO2B1/FOLR2	-0.128028291524735
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/973	83/9376	0.928788122686017	SOD1/PRDX1/PRDX5/SOD2/ACAA1/ACSL1/PXMP4/ACOT8	-0.221737113193916
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/973	63/9376	0.917731121225469	GPX4/PLA2G12A/ALOX5/CBR1/TBXAS1/LTC4S	-0.222938938139974
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/973	21/9376	0.917731121225469	DSE/B3GAT3	-0.128424595485493
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/973	115/9376	0.921721256535145	GNG5/PLCB2/ALOX5/PRKCB/DUSP1/NRAS/GNB1/GNB2/GNAI3/GNAS/GNAQ	-0.287401281546972
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/973	32/9376	0.903391572456321	HK3/G6PC3/GALK1	-0.186272380254348
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/973	238/9376	0.931227167125843	IGF2/CALM2/GNG5/CALM1/MAP2K2/PLA2G12A/VEGFA/GRB2/PRKCB/VEGFB/NRAS/RAP1B/MRAS/GNB1/RAC1/GNB2/RASGRP3/RASA3/INSR/RASSF5/SOS2/CHUK/MAPK9	-0.365682933584814
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/973	65/9376	0.889493240572377	SPP1/MAP2K2/PLCB2/PRKCB/NRAS/GNAQ	-0.304209123734912
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/973	22/9376	0.876016070260675	AOC1/ALDH1B1	-0.198108418777116
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/973	44/9376	0.876016070260675	DAD1/B4GALT3/ALG3/MGAT4B	-0.280497662968976
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/973	76/9376	0.887542597500947	CALM2/CALM1/PLCB2/PRKCB/GNAI3/GNAS/GNAQ	-0.334948661426622
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/973	23/9376	0.837928415031949	HMGCR/PDSS2	-0.264801357204772
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/973	23/9376	0.837928415031949	POLD4/SSBP1	-0.264801357204772
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/973	232/9376	0.913775383633979	FN1/TMSB4X/ITGB2/GSN/CXCR4/BRK1/ACTR3/MAP2K2/ARPC1B/ITGAX/NCKAP1L/ITGAM/NRAS/MRAS/RAC1/CRK/MYL12B/LPAR5/LIMK2/SOS2/CFL2/ITGA2B	-0.452514011470922
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/973	78/9376	0.864785095000922	FN1/ACTR3/ARPC1B/ILK/MAD2L2/RAC1/CRK	-0.408039281671455
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/973	47/9376	0.820100150882334	ME2/AKR1A1/ALDH1B1/ME1	-0.420714090985621
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/973	47/9376	0.820100150882334	HK3/IRS2/INSR/MAPK9	-0.420714090985621
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/973	122/9376	0.868835610668374	MDM2/MAP2K2/PLCB2/PRKCB/HDAC3/NRAS/NCOA2/MED27/MED4/MED13L/HIF1A	-0.496199115680379
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/973	154/9376	0.876016070260675	ATF4/CALM2/TNNI3/CALM1/PPP2CA/PLCB2/PPP2R3C/SCN1B/CREB5/SLC8A1/TPM3/GNAI3/GNAS/GNAQ	-0.527883485367199
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/973	91/9376	0.84713641959274	GNG5/PDE4C/PRKCB/GNB1/GNB2/PDE4A/GNAI3/GNAS	-0.498607315588379
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/973	48/9376	0.803014731072285	HK3/PLCB2/PRKCB/G6PC3	-0.465569987560313
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/973	37/9376	0.781311630232494	GLUL/IL4I1/GOT1	-0.45352500626973
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/973	71/9376	0.814324797707106	MAP2K2/PGAM1/HK3/NRAS/G6PD/HIF1A	-0.534379473749756
NA	NA	hsa04081	Hormone signaling	20/973	219/9376	0.88001614364086	IGF2/HAMP/CSH1/GNG5/ADIPOR1/PLCB2/IRS2/AMHR2/ADIPOR2/CCK/SMAD4/POMC/GNB1/GNB2/GNA15/GNAI3/INSR/GNAS/STAT3/GNAQ	-0.611354542166359
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/973	49/9376	0.786626675336116	LFNG/B4GALT3/MFNG/OGT	-0.509556155627744
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/973	26/9376	0.741244367143648	PLA2G12A/ACAA1	-0.449568172896742
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/973	38/9376	0.760750797857954	NT5M/NT5C/PNP	-0.502852065336654
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/973	38/9376	0.760750797857954	CD4/PTPRC/CD40	-0.502852065336654
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/973	14/9376	0.688298340919101	B4GALT3	-0.397140053419706
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/973	39/9376	0.741244367143648	MAT2A/AHCYL1/MTHFD2	-0.550989488151983
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/973	149/9376	0.840740255350849	FCER1G/CYTH4/MAP2K2/PLCB2/GRB2/NRAS/DGKE/MRAS/LPAR5/ARF1/INSR/SOS2/GNAS	-0.666797196995194
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/973	63/9376	0.764775934354557	CDKN1A/GADD45A/BAX/DDB2/GADD45B	-0.637429416823376
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/973	28/9376	0.688298340919101	HADHB/ECHS1	-0.562061262101293
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/973	41/9376	0.705086105331762	BABAM1/POLD4/SSBP1	-0.643954049058958
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/973	65/9376	0.741244367143648	LPL/DGKE/AKR1A1/PNPLA2/ALDH1B1	-0.712316827861187
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/973	29/9376	0.664563915370167	TEAD1/RASSF4	-0.615598473583834
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/973	155/9376	0.808195471272751	CDKN1A/ATF4/CDK4/MAP2K2/PLCB2/AHR/RAP1B/POMC/CREB5/GNAI3/GNAS/SP1/GNAQ	-0.819333235150653
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/973	30/9376	0.642411784857828	SDHA/IDH3B	-0.667506982628546
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/973	134/9376	0.791029436578669	MYL6/CALM2/CALM1/MAP2K2/PLA2G12A/PLCB2/KCNMA1/PRKCB/GNAS/ADM/GNAQ	-0.829047487180114
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/973	55/9376	0.70081285620854	PSAP/GM2A/NEU1/CERS2	-0.757212709984597
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/973	79/9376	0.731861527053222	GSTP1/AKR1C1/GSTO1/GSTT1/CBR1/GSTM3	-0.814378197932369
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/973	17/9376	0.566833927815731	GLUL	-0.608259704606558
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/973	17/9376	0.566833927815731	NRP2	-0.608259704606558
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/973	31/9376	0.621688824055963	AKR1A1/ALDH1B1	-0.717902130019042
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/973	56/9376	0.688298340919101	DAD1/B4GALT3/ALG3/MGAT4B	-0.796067782027583
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/973	57/9376	0.676222931429293	HADHB/ECHS1/ACAA1/ACSL1	-0.834302865548515
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/973	32/9376	0.602261048304214	ECHS1/PCCA	-0.766887352749284
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/973	45/9376	0.642411784857828	ABCC3/ABCA1/ABCG1	-0.81818259433703
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/973	18/9376	0.53534315404819	ACSL1	-0.671431865869403
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/973	18/9376	0.53534315404819	NEU1	-0.671431865869403
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/973	18/9376	0.53534315404819	PRDX1	-0.671431865869403
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/973	70/9376	0.688298340919101	GSTP1/GSTO1/GSTT1/CBR1/GSTM3	-0.890700069810248
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/973	117/9376	0.741244367143648	MORF4L1/BRD8/CHRAC1/INO80B/PHF10/BCL7B/CDK2AP2/VPS72/INO80D	-0.958353157617385
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/973	59/9376	0.653300120194401	NT5M/NT5C/DPYD/RRM2B	-0.909005530925499
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/973	19/9376	0.507167198571969	IDS	-0.731699852889556
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/973	20/9376	0.481808838643371	LIPA	-0.789377546463409
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/973	98/9376	0.688298340919101	CALM2/CALM1/PI4K2B/PLCB2/PRKCB/DGKE/INPP5F	-1.05547960095324
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/973	36/9376	0.53534315404819	HK3/G6PC3	-0.950462592570995
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/973	36/9376	0.53534315404819	POLD4/SSBP1	-0.950462592570995
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/973	157/9376	0.736523065442096	BBC3/SERPINE1/ITGB2/YWHAZ/PPP2CA/TEAD1/SMAD2/TGFBR1/SMAD4/BIRC3/PARD6A/PRKCI	-1.13285779483347
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/973	37/9376	0.520874420154996	IL4I1/GOT1	-0.993630488142584
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/973	51/9376	0.566833927815731	PLA2G12A/PLA2G7/PLD3	-1.05545562176856
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/973	183/9376	0.737193851476196	NOP58/NOP56/RCL1/CSNK2A1/GNL2/RPP25L/WDR43/WDR75/NOB1/MPHOSPH10/IMP3/RPP40/NOP10/XRN1	-1.2216795747799
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/973	38/9376	0.507167198571969	PRKCB/INSR	-1.03583205229081
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/973	52/9376	0.555933275357736	ALOX5/INSR/GNAS	-1.09263132492665
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/973	138/9376	0.698273679193291	RBX1/SKP1/CALM2/ANAPC16/CALM1/YWHAZ/PPP2CA/MAD2L2/ANAPC13/PPP3CB	-1.21503457923357
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/973	23/9376	0.418964207515975	B4GALT3	-0.949327832294913
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/973	23/9376	0.418964207515975	ATP6AP2	-0.949327832294913
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/973	79/9376	0.609884605877685	ATP6V0E1/ATP6V0B/AP2B1/VAMP2/STX3	-1.18484105678511
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/973	24/9376	0.401507365536142	B3GAT3	-0.998934605362449
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	20/973	254/9376	0.758754076603734	CXCR4/CALM2/CALM1/PTAFR/VDAC2/PPIF/VEGFA/PLCB2/P2RX7/PRKCB/VEGFB/SLC8A1/GNA15/SLC25A4/ORAI3/ASPH/NFATC3/PPP3CB/GNAS/GNAQ	-1.32634554878674
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/973	105/9376	0.642411784857828	TNNI3/EMD/SLC8A1/TPM3/GNAS/ITGA2B/SNTB1	-1.25383224103012
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/973	41/9376	0.470057403554508	SDS/PGAM1	-1.15714683817726
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/973	43/9376	0.448194268505461	ABCA1/PLA2G12A	-1.2340554618729
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/973	27/9376	0.356895436032127	ACAA1	-1.13869069153943
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/973	44/9376	0.438008035130337	POLD4/NTHL1	-1.27143439544717
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/973	99/9376	0.584010713507116	TNNI3/EMD/SLC8A1/TPM3/ITGA2B/SNTB1	-1.41586172421612
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/973	184/9376	0.680816837213459	CXCR4/ILK/PLXNC1/NRAS/SEMA4A/RAC1/PARD6A/MYL12B/LIMK2/GNAI3/NFATC3/PPP3CB/CFL2	-1.48788290528285
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/973	73/9376	0.528009686184516	GSTP1/GSTO1/GSTT1/GSTM3	-1.37755162141416
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/973	28/9376	0.344149170459551	B4GALT3	-1.18263196316838
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/973	28/9376	0.344149170459551	CBR1	-1.18263196316838
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/973	28/9376	0.344149170459551	ATP6V0E1	-1.18263196316838
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/973	323/9376	0.745834115547014	CDKN1A/HMOX1/TIMP3/MDM2/VIM/DDIT4/CD44/MAP2K2/MCL1/ST14/MMP9/VEGFA/GRB2/IRS2/DICER1/PRKCB/MARCKS/NRAS/PDCD4/FSCN1/HNRNPK/CRK/MIR29A/SOS2/STAT3	-1.58178383975444
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/973	89/9376	0.541358245666709	SPP1/FN1/CD44/GP9/ITGA2B	-1.47929826226411
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/973	30/9376	0.321205892428914	PLA2G12A	-1.26709938242978
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/973	90/9376	0.53534315404819	ABCC3/AQP9/SLC27A5/HMGCR/GNAS	-1.50717656180985
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/973	63/9376	0.458865560612734	ECHS1/ASH1L/ALDH1B1	-1.46641037419018
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	16/973	226/9376	0.682207205158755	CALM2/TNNI3/PDE4C/NFKBIA/CALM1/MAP2K2/JUN/FOS/RAP1B/POMC/RAC1/CREB5/PDE4A/GNAI3/GNAS/MAPK9	-1.64555573159461
Human Diseases	Substance dependence	hsa05034	Alcoholism	13/973	191/9376	0.655865434802495	ATF4/CALM2/GNG5/CALM1/GRB2/HDAC3/NRAS/GNB1/GNB2/CREB5/GNAI3/SOS2/GNAS	-1.63504712987888
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/973	78/9376	0.494162911429098	PI4K2B/PLCB2/TPI1/INPP5F	-1.52646930650625
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/973	144/9376	0.602261048304214	MAP2K2/LIF/GRB2/NRAS/SMAD2/SMAD4/KLF4/IL6ST/STAT3	-1.63665201474841
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/973	233/9376	0.661711709724801	FN1/VIM/FMNL1/TNNI3/SUN1/SDC2/TMOD1/FBN1/EMD/TPM3/FMNL2/SYNE2/CSRP2/ITGA2B/FMNL3/SNTB1	-1.77928469183947
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/973	110/9376	0.525609642156405	HSP90AB1/ANAPC16/MAD2L2/ANAPC13/GNAI3/MAPK9	-1.70298539908576
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/973	36/9376	0.267671577024095	AKR1A1	-1.49798884398078
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/973	86/9376	0.448194268505461	EMD/SLC8A1/ITGA2B/SNTB1	-1.74925229463249
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/973	56/9376	0.344149170459551	CSNK1A1/CUL3	-1.67500460778013
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/973	66/9376	0.292005356753558	AKR1C1/DHRS11	-1.96404744912499
NA	NA	hsa03272	Virion - Hepatitis viruses	1/973	48/9376	0.200753682768071	CLDN5	-1.88899961909254
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/973	68/9376	0.283416963907865	ALDH1A1/DHRS4L2	-2.0179837669323
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/973	103/9376	0.374220457198735	SLC3A2/SLC38A2/SLC7A7/SLC8A1	-2.17297495421532
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/973	104/9376	0.370622183571824	PLA2G12A/DGKE/PLD3/ACHE	-2.19617157447889
NA	NA	hsa04082	Neuroactive ligand signaling	10/973	199/9376	0.484229988586303	GNG5/PLCB2/PRKCB/POMC/GNB1/GNB2/ACHE/GNAI3/GNAS/GNAQ	-2.50240233212983
NA	NA	hsa04382	Cornified envelope formation	11/973	217/9376	0.488469790329685	S100A6/S100A4/S100A2/KRT10/ST14/PPP2CA/PPP2R3C/PADI2/CLDN5/TJP1/S100A8	-2.59419131540354
NA	NA	hsa04519	Cadherin signaling	23/973	404/9376	0.5485942222177	VIM/BRK1/NFKBIA/ACTR3/LHFPL2/MAP2K2/ARPC1B/YWHAZ/NCKAP1L/KRT10/TEAD1/PSENEN/NRAS/SCN1B/CSNK1A1/MRAS/RAC1/MAP2K3/TAOK3/TJP1/MYO1F/CHUK/MAPK9	-3.15600759883479
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/973	86/9376	0.112048567126365	PLCB2	-2.81485130150698
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/973	370/9376	0.286480931085248	FPR3/CSH1/C5AR1/C3AR1/PTAFR/FPR1/P2RX7/PTGER4/CCK/POMC/ADM	-4.7650268426889
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/973	449/9376	0.107307091011887	CALM2/RGS2/CALM1/GNB1/SLC8A1	-6.59625391113016