category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	137/2273	250/9376	2.26046986361637	CTSA/LAPTM4A/LAPTM4B/CTSB/ASAH1/SLC15A4/LGMN/LITAF/CTSD/FUCA1/CTSS/CTSH/TPCN1/PSAP/CD68/GNPTAB/FUCA2/LAMP1/ATP6V1D/GNPTG/ATP6AP1/ATP6V0A2/CTSZ/VPS41/NAPSA/MITF/NEU1/ATP6V0B/SMPD1/LAMP2/IDS/ARSA/VPS13C/M6PR/CTNS/ATP6V0A1/CD63/SUMF1/HEXA/GLB1/CLN5/BLOC1S5/GGA2/SCARB2/CTSC/DNASE2/ARL8A/CTBS/ABCA5/OSBP/NCOA7/TMEM175/AP2B1/PPT1/VPS35/SNAPIN/GNS/ARSG/NAGLU/PLA2G15/TLR3/LIPA/OSBPL2/AP1G1/ATP6V1C1/GAA/LAPTM5/AP2A2/CD164/GUSB/DMXL1/AP3B1/HGSNAT/BLOC1S6/CLTC/SLC17A5/SLC11A2/ATP6V1H/MFSD8/CLCN7/CTSO/HYAL2/ENTPD4/ACP2/GGA1/ATP6V0E2/NAGA/TPP1/IGF2R/SPG11/NAGPA/CLN8/SGSH/DTNBP1/LAMP3/AP4M1/OSTM1/RRAGB/HEXB/VPS13A/MCOLN1/TCIRG1/AP1S2/SORT1/OSBPL1A/PLEKHM1/NPC1/ARSB/AGA/SLC15A3/OSBPL3/ACP5/NPC2/SLC11A1/CTSW/AP1G2/GPR155/CLN6/GALC/OSBPL5/VPS33A/AP5Z1/TLR7/AP5B1/ZFYVE26/GALNS/RRAGD/MANBA/CTSK/CTSF/PIKFYVE/WDR7/FIG4/AP4S1/DMXL2/ATP6V1E2/TPCN2	11.4268542375714
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	92/2273	174/9376	2.18100540578809	HSP90B1/TRAM1/PDIA3/SEC63/BCL2/RPN1/MAP3K5/DNAJC3/SEC62/BCAP31/RRBP1/DERL2/HERPUD1/LMAN2/OS9/PDIA4/HSPA5/HYOU1/DNAJC1/ERLEC1/LMAN1/ERN1/MBTPS1/DNAJC10/BCAP29/MAGT1/CAPN2/SIL1/SEC61A1/SAR1B/CANX/NFE2L2/UGGT2/DERL1/SSR1/SEL1L/DNAJB2/STT3B/RPN2/DAD1/SSR4/DNAJB12/KRTCAP2/DDOST/STT3A/XBP1/DNAJB11/MAN1B1/EDEM2/SVIP/SEC31A/MOGS/SEC23B/PPP1R15A/PDIA6/UBXN2A/PRKCSH/WFS1/CKAP4/UBE2D1/DDIT3/ATF6/ERP29/AMFR/HSPA1B/GANAB/UBE2G1/SYVN1/UBXN4/UGGT1/CALR/UBE2G2/EDEM3/HSPA1A/ATF6B/P4HB/SSR3/NPLOC4/SEC23A/CRYAB/EIF2AK3/FBXO6/SSR2/UBE4B/DNAJB1/TXNDC5/SEC24B/DERL3/YOD1/MAPK10/HSPA4L/MBTPS2	8.89507970383079
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	104/2273	250/9376	1.71597712274527	HLA-B/HLA-A/HLA-E/HLA-C/EEA1/ARFGAP3/CXCR4/SMURF1/ARFGEF1/FGFR2/CYTH2/RAB11FIP1/SMAD3/EHD4/CHMP1B/CHMP4C/FOLR1/ARF1/PARD6B/VPS25/TGFBR2/VPS4B/TSG101/AP2B1/IST1/VPS35/PDCD6IP/RAB11B/RAB10/RAB5B/IGF1R/WWP1/HSPA1B/ARFGAP2/AP2A2/FOLR2/SMAP1/VPS4A/STAM2/USP8/SNX4/CAV2/CLTC/WIPF2/ACTR3/ARF4/RAB22A/PDGFRA/RUFY1/BIN1/IGF2R/NEDD4L/CHMP1A/VPS36/HSPA1A/PIP5K1A/ACAP2/EGFR/PARD3/ITCH/AGAP3/RAB35/RUFY2/SMURF2/ARFGEF2/HLA-F/PRKCI/ACTR3C/GBF1/WIPF1/ARAP2/DNAJC6/SMAP2/ZFYVE27/ARFGAP1/SRC/PML/PSD4/ARRB2/GIT2/RAB11FIP3/CYTH1/RNF41/CYTH4/EHD2/ASAP2/GIT1/ACAP1/PARD6A/ARAP1/SNX12/RAB11FIP2/GRK4/TRAF6/RAB11FIP5/TGFBR1/PLD2/AGAP1/VPS45/WIPF3/ACTR3B/IL2RA/ARRB1/PSD3	6.49072735112695
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	67/2273	155/9376	1.78304074478804	HLA-B/HLA-A/HLA-E/CYBA/HLA-DMA/HLA-DRA/HLA-C/CTSS/HLA-DMB/HLA-DRB1/LAMP1/ATP6V1D/EEA1/ATP6AP1/ATP6V0A2/STX7/ATP6V0B/COMP/LAMP2/HLA-DPA1/SEC61A1/M6PR/CANX/ATP6V0A1/ITGB3/HLA-DPB1/DYNC1H1/RAB5B/FCGR3A/HLA-DQA2/ITGB5/CD14/ATP6V1C1/TAP1/DYNC1LI1/HLA-DQB1/ATP6V1H/ITGB2/ATP6V0E2/ITGAV/ITGA2/CALR/MSR1/FCGR2A/C3/TCIRG1/HLA-DQA1/HLA-F/SFTPD/PIK3C3/ITGAM/DYNC1I1/HLA-DOB/CORO1A/DYNC2H1/CYBB/MARCO/HLA-DOA/SCARB1/TLR4/FCGR1A/NCF1/NCF2/NCF4/PIKFYVE/ATP6V1E2/TLR2	5.5606511152084
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	21/2273	30/9376	2.88746150461945	PIGH/PIGT/PIGK/PIGF/PIGX/PIGC/B3GALT4/GPAA1/PIGV/PIGS/PIGO/PIGU/PIGG/PIGM/PIGQ/PIGA/PIGL/PGAP3/PIGZ/PIGN/PIGW	5.85720319438923
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	74/2273	181/9376	1.68644160490796	HLA-DMA/CD74/HLA-DRA/CTSD/BCL2/CTSS/HLA-DMB/HLA-DRB1/LAMP1/IFNGR1/EEA1/ATP6AP1/ATP6V0A2/STAT1/CALM2/ATP6V0B/LAMP2/HLA-DPA1/TRADD/ARHGEF12/ATP6V0A1/MAPK14/JAK1/HLA-DPB1/IFNGR2/RAB5B/FCGR3A/HLA-DQA2/CD14/TNFRSF1A/HLA-DQB1/FCER1G/ATP6V1H/SPHK1/LBP/ITGB2/CREBBP/TLR1/EP300/FCGR2A/C3/TCIRG1/HLA-DQA1/IL18/LSP1/PIK3C3/CAMK2D/PLK3/SRC/ITGAM/TGFB2/HLA-DOB/ITGAX/CORO1A/IRAK4/SYK/PPP3CC/MALT1/RFX5/KSR1/HLA-DOA/TLR4/FCGR1A/TRAF6/APAF1/MAPK10/IL10/BID/SPHK2/CIITA/TIRAP/CARD9/JAK2/TLR2	5.2751093580229
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	67/2273	160/9376	1.72732072151342	HLA-B/HLA-A/VCAN/HLA-E/CLDN10/HLA-DMA/HLA-DRA/HLA-C/CLDN3/CLDN4/HLA-DMB/HLA-DRB1/CLDN1/CDH1/SDC2/CD99/ALCAM/HLA-DPA1/SDC1/CLDN7/CD58/HLA-DPB1/GLG1/SDC4/HLA-DQA2/OCLN/ESAM/CXADR/PVR/HLA-DQB1/ITGB2/ITGAV/ICOSLG/CD4/PTPRC/CLDN12/HLA-DQA1/HLA-F/NEO1/ITGAM/SELPLG/HLA-DOB/CLDN23/CADM1/SIGLEC1/ICAM3/SDC3/JAM2/SLITRK4/HLA-DOA/LRRC4C/CD86/PTPRM/CD40/VTCN1/NCAM1/CLDN16/ITGAL/CD99L2/ITGB7/ICAM2/CLDN8/CLDN9/CD22/VCAM1/ITGA4/ICAM1	5.24903136554896
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	69/2273	169/9376	1.68414914470619	CTSB/GABARAPL1/CTSD/BCL2/LAMP1/VPS41/ERN1/STX7/DAPK1/VMP1/CALCOCO2/LAMP2/CFLAR/NBR1/RRAS2/GABARAPL2/WIPI1/PRKAA2/WIPI2/TAX1BP1/GORASP2/OPTN/IGF1R/RRAS/PDPK1/BIRC6/MAP2K1/NRBF2/BCL2L1/RB1CC1/SQSTM1/EIF2AK4/RHEB/WDFY3/WDR45/MTMR14/IRS2/PRKAA1/SUPT20H/RRAGB/ATG4D/PIK3CA/TSC2/PLEKHM1/PIK3C3/WDR41/ATG14/ULK2/EIF2AK3/CAMKK2/ATG9A/EPG5/C9orf72/ATG7/RAB33B/MRAS/ATG9B/IRS1/TRAF6/ATG2A/VPS33A/DAPK2/MTMR3/ATG2B/MAPK10/ZFYVE1/GORASP1/RRAGD/ATG16L2	5.07691062216416
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	30/2273	55/9376	2.24997000359957	ASAH1/DEGS1/CERS2/PSAP/NEU1/SMPD1/ARSA/KDSR/HEXA/GLB1/SPTLC2/SGPL1/UGT8/SPTLC3/CERK/SGMS2/SPTLC1/SPHK1/SGMS1/CERS6/HEXB/UGCG/SGPP2/GBA2/ACER3/SMPD2/CERS4/GALC/SAMD8/SPHK2	5.25913271638419
NA	NA	hsa03272	Virion - Hepatitis viruses	27/2273	48/9376	2.32028156621205	CD9/EPCAM/CLDN10/CD81/CLDN3/CLDN4/TGOLN2/CLDN1/LAMP1/LAMP2/CLDN7/CD63/CHMP1B/VPS4B/TSG101/IST1/PDCD6IP/OCLN/VPS4A/CHMP1A/EGFR/CLDN12/CLDN23/SCARB1/CLDN16/CLDN8/CLDN9	5.18749102582205
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	84/2273	224/9376	1.5468543774747	HLA-B/HLA-A/B2M/HLA-E/HLA-DMA/HLA-DRA/HLA-C/HLA-DMB/HLA-DRB1/CCND1/IL1R2/HLA-DPA1/CANX/JAK1/SMAD3/ATM/CREB3L1/HLA-DPB1/XIAP/LTBR/NFATC3/IL1R1/TGFBR2/RB1/TLN1/MAP2K1/HLA-DQA2/SLC25A4/CREB3L2/TNFRSF1A/CHEK2/BCL2L1/HLA-DQB1/ELK4/MAP3K1/MAP3K3/ZFP36/ITGB2/CDKN1A/CREBBP/SMAD4/ATF2/CALR/ATF6B/EP300/CD4/HLA-DQA1/MAP2K4/TSPO/JUN/HLA-F/PIK3CA/IKBKB/CRTC3/TGFB2/HLA-DOB/DLG1/SPI1/IL15RA/PPP3CC/VAC14/CDKN2A/ADCY6/IL15/NFKBIA/CDKN2B/EGR2/ETS1/HLA-DOA/CD40/GPS2/ITGAL/MAPK10/MMP7/TGFBR1/ADCY7/ATR/TRRAP/STAT5A/ADCY3/CREB3L4/CD3E/IL2RA/ICAM1	4.68599849831047
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	37/2273	78/9376	1.95670468261757	CYBA/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DRB1/IFNGR1/STAT1/HLA-DPA1/MAPK14/JAK1/HLA-DPB1/IFNGR2/FCGR3A/HLA-DQA2/HLA-DQB1/ITGB2/FCGR2A/C3/HLA-DQA1/JUN/ITGAM/TGFB2/HLA-DOB/CYBB/IRAK4/NFKBIA/HLA-DOA/TLR4/FCGR1A/TRAF6/NCF1/NCF2/NCF4/IL10/ITGA4/JAK2/TLR2	4.79948765323693
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	67/2273	170/9376	1.62571362024792	CLDN10/CLDN3/CLDN4/MAP3K5/MSN/CLDN1/TJP1/CCND1/CLDN7/CTTN/SYMPK/PRKAB1/PRKAG2/ROCK2/RUNX1/CRB3/PRKAA2/PARD6B/ACTN4/LLGL2/AMOTL2/RAP1A/YBX3/ERBB2/WHAMM/OCLN/ROCK1/TJP2/ACTR3/MAP3K1/MARVELD2/NEDD4L/NF2/PPP2R1B/PRKAA1/MAGI1/CGN/PARD3/CLDN12/JUN/PRKCI/ACTR3C/SYNPO/RAPGEF2/SRC/DLG1/CLDN23/WAS/MARVELD3/ARHGAP17/PPP2R2D/JAM2/PARD6A/ARHGEF18/SCRIB/EZR/CLDN16/MYH14/MAPK10/TIAM1/EPB41L4B/RAPGEF6/AMOT/CLDN8/CLDN9/ACTR3B/MICALL2	4.65724443830274
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	34/2273	70/9376	2.00354471749104	HLA-B/HLA-A/HLA-E/HLA-DMA/HLA-DRA/HLA-C/CD55/HLA-DMB/HLA-DRB1/CCND1/HLA-DPA1/HLA-DPB1/SGCB/EIF4G1/HLA-DQA2/CXADR/HLA-DQB1/EIF4G3/SGCE/ITGB2/ABL2/SNTB2/HLA-DQA1/HLA-F/SSPN/SNTB1/HLA-DOB/HLA-DOA/CD86/CD40/ITGAL/BID/PRF1/ICAM1	4.76725819359203
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	69/2273	180/9376	1.58122891919636	HLA-B/HLA-A/B2M/HLA-E/HLA-DMA/CD74/HLA-DRA/HLA-C/PDIA3/BCL2/HLA-DMB/HLA-DRB1/IFNGR1/STAT1/HLA-DPA1/TRADD/IFNAR1/TAPBP/SP100/JAK1/ITGB3/HLA-DPB1/TAPBPL/IFNGR2/TNFRSF14/EIF2AK2/HLA-DQA2/TLR3/IRF7/TAP1/STAT2/PTPN11/FAS/TNFRSF1A/BCL2L1/HLA-DQB1/BST2/RHEB/OAS1/CALR/C3/PILRB/HLA-DQA1/HLA-F/PIK3CA/TSC2/IKBKB/OAS2/SRC/PML/HLA-DOB/IRAK4/SYK/NFKBIA/IRF9/NXF1/HLA-DOA/BIRC3/TRAF6/PILRA/HCFC2/APAF1/TRAF5/MAVS/BID/POU2F2/CARD9/JAK2/TLR2	4.45398176414773
Human Diseases	Immune disease	hsa05330	Allograft rejection	22/2273	39/9376	2.32689205500468	HLA-B/HLA-A/HLA-E/HLA-DMA/HLA-DRA/HLA-C/HLA-DMB/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQA2/FAS/HLA-DQB1/HLA-DQA1/HLA-F/HLA-DOB/HLA-DOA/CD86/CD40/GZMB/IL10/PRF1	4.69708767281342
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	75/2273	200/9376	1.5468543774747	TNFSF10/CLDN10/CLDN3/CLDN4/CLDN1/TMED10/TJP1/TMBIM6/BAIAP2/TRADD/CLDN7/ARHGEF12/CTTN/MAPK14/CYTH2/ROCK2/MYO1E/MYO1C/ARF1/IL1R1/MYO6/NCKAP1/MYO5C/OCLN/ROCK1/PTPN11/FAS/TNFRSF1A/WIPF2/ACTR3/ABI1/PAK2/TNFRSF10A/MYO1D/FCGR2A/CLDN12/MYO10/JUN/IL18/ACTR3C/WIPF1/NCKAP1L/IKBKB/SRC/CASP1/CLDN23/IRAK4/CYTH1/CYTH4/RIPK1/TNFRSF10B/TLR5/NFKBIA/LPAR1/ABCF2/F2R/ARHGEF1/NAIP/MYO5B/TLR4/SEC24B/TRAF6/MYO5A/EZR/CLDN16/MYH14/MAPK10/MYO1F/TIRAP/CLDN8/LPAR2/CLDN9/WIPF3/ACTR3B/ARHGEF11	4.42205802559496
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	54/2273	133/9376	1.6747897019275	TNFSF10/GABARAPL1/SOD2/IGF1/CAT/STAT3/CCND1/GADD45B/PRKAB1/SGK1/MAPK14/PRKAG2/CDKN1B/SMAD3/ATM/GABARAPL2/FBXO32/PRKAA2/TGFBR2/IGF1R/PDPK1/MAP2K1/G6PC3/STK4/SOS2/CDKN1A/CREBBP/RBL2/SMAD4/IRS2/PRKAA1/BCL2L11/EP300/EGFR/PIK3CA/CSNK1E/BCL6/SIRT1/PLK3/IKBKB/SGK3/TGFB2/ARAF/CDKN2B/CDKN2D/IRS1/FBXO25/MAPK10/IL10/KLF2/INSR/TGFBR1/S1PR4/PCK1	4.43355641281143
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	76/2273	205/9376	1.52924790488556	HLA-B/HLA-A/B2M/HLA-E/HLA-DMA/HLA-DRA/HLA-C/PDIA3/BCL2/HLA-DMB/HLA-DRB1/STAT1/STAT3/CCND1/HLA-DPA1/TRADD/IFNAR1/GADD45B/TAPBP/CD58/MAPK14/JAK1/CDKN1B/HLA-DPB1/TAPBPL/CD44/RB1/HES1/EIF2AK2/HLA-DQA2/CIR1/POLK/IRF7/TAP1/STAT2/FAS/HLA-DQB1/CDKN1A/OAS1/CALR/BCL2L11/MAP2K3/HLA-DQA1/MAP2K4/RBPJ/JUN/SAP30L/HLA-F/PIK3CA/IKBKB/OAS2/HLA-DOB/NCOR2/IRAK4/SYK/RIPK1/NFKBIA/CXCL10/IRF9/ENTPD1/HLA-DOA/SIN3A/CD40/TRAF6/RUNX3/APAF1/TRAF5/ITGAL/MAPK10/VIM/MAVS/BID/CD3E/ICAM1/CD247/TLR2	4.3340326628775
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	28/2273	56/9376	2.0624725032996	RPN1/SRD5A3/ALG5/MAGT1/ALG2/ST6GAL1/DHRSX/STT3B/RPN2/DAD1/MGAT4B/DPM3/KRTCAP2/DDOST/STT3A/MAN1B1/MOGS/GANAB/MGAT4A/MGAT2/MAN2A1/ALG12/DPAGT1/B4GALT2/ALG8/ALG1/DOLPP1/ALG11	4.51095199501578
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	30/2273	62/9376	1.99594113222542	JAG1/PSENEN/TLE2/APH1A/SPEN/RFNG/NUMB/HES1/NCSTN/CIR1/DTX3L/APH1B/NOTCH2/PSEN1/CREBBP/EP300/ITCH/RBPJ/ATXN1L/ADAM17/MAML1/ATXN1/NCOR2/TLE6/MAML2/PSEN2/DTX3/MFNG/DTX2/NOTCH1	4.45067462700725
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	56/2273	142/9376	1.62673887584194	CYBA/TNFRSF11B/IFNGR1/STAT1/MITF/IFNAR1/FOSL2/MAPK14/JAK1/TYROBP/ITGB3/IL1R1/IFNGR2/TGFBR2/ATP2A2/FCGR3A/MAP2K1/STAT2/TNFRSF1A/CYLD/SQSTM1/JUNB/SIRPA/TREM2/FCGR2A/JUND/JUN/PIK3CA/ITPR2/FOSB/LCP2/IKBKB/ITPR3/TGFB2/ACP5/LILRB4/SPI1/SYK/PPP3CC/NFKBIA/IRF9/LILRB1/CSF1R/FCGR1A/TRAF6/NCF1/NCF2/MAPK10/NCF4/OSCAR/LILRB5/TGFBR1/CTSK/TEC1/LILRB2/CSF1	4.25696735834632
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	46/2273	112/9376	1.6941738419961	LAMB3/HLA-DMA/HLA-DRA/BCL2/HLA-DMB/LAMC1/HLA-DRB1/IFNGR1/STAT1/STAT3/HLA-DPA1/GNAI2/MAPK14/JAK1/HLA-DPB1/XIAP/IFNGR2/LAMA5/PDPK1/HLA-DQA2/HSPA1B/ALOX5/TNFRSF1A/BCL2L1/HLA-DQB1/LY96/HSPA1A/MAP2K3/HLA-DQA1/LAMB2/IKBKB/TGFB2/HLA-DOB/LAMC2/IRAK4/NFKBIA/HLA-DOA/BIRC3/TLR4/CD40/TRAF6/MAPK10/IL10/CIITA/JAK2/TLR2	4.18063672517983
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	13/2273	19/9376	2.82233079398893	IDS/HEXA/GLB1/GNS/NAGLU/HPSE/GUSB/HGSNAT/HYAL2/SGSH/HEXB/ARSB/GALNS	4.49780008651868
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	45/2273	109/9376	1.70295894767857	HLA-DMA/HLA-DRA/HLA-DMB/HLA-DRB1/IFNGR1/STAT1/STAT3/HLA-DPA1/RORC/MAPK14/IL6ST/JAK1/RUNX1/SMAD3/HLA-DPB1/NFATC3/IL1R1/IFNGR2/TGFBR2/IL6R/HLA-DQA2/HLA-DQB1/SMAD4/STAT6/CD4/RXRB/IL4R/HLA-DQA1/JUN/AHR/IKBKB/HLA-DOB/PPP3CC/NFKBIA/RORA/HLA-DOA/MAPK10/TGFBR1/STAT5A/CD3E/IL2RA/JAK2/CD247/LAT/RARA	4.17578451479632
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	60/2273	157/9376	1.57641210443282	C1QA/C1QB/VPS41/ATP11A/SGK1/MAPK14/TMEM30A/ITGB3/NFATC3/GAS6/C1QC/ATP2A2/TMEM30B/RAB5B/PLA2G15/CD47/MAP2K1/DUSP4/LIPA/GULP1/ITGB5/MAPKAPK2/RAB17/ADAM10/ALOX5/PTPN11/SPHK1/SIRPA/ITGAV/PTGER2/CALR/PTGER4/CPT1A/ABCA1/ADAM9/HAVCR2/ATP8A1/BCAR1/SIRT1/CAMK2D/AXL/ADAM17/ANO6/STAB1/CASP1/MERTK/VPS33A/SIGLEC10/TGFBRAP1/ATP11B/IL10/CX3CL1/CX3CR1/CPT1B/DUSP16/DUSP2/NR1H3/SPHK2/PLA2G6/JAK2	4.12007820551006
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	36/2273	82/9376	1.81095146631185	HLA-B/HLA-A/B2M/HLA-E/CTSB/HLA-DMA/CD74/LGMN/HLA-DRA/HLA-C/PDIA3/CTSS/HLA-DMB/HLA-DRB1/HSPA5/HLA-DPA1/CANX/TAPBP/HLA-DPB1/TAPBPL/HLA-DQA2/HSPA1B/TAP1/HLA-DQB1/CALR/HSPA1A/CD4/HLA-DQA1/HLA-F/IFI30/HLA-DOB/RFX5/HLA-DOA/KLRC2/KLRC1/CIITA	4.1721979394306
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	47/2273	116/9376	1.67131392508761	CYBA/CLDN10/CLDN3/CLDN4/MSN/CLDN1/CD99/CXCR4/CLDN7/GNAI2/CTNNA1/MAPK14/RAPGEF3/ROCK2/ACTN4/RAP1A/OCLN/ESAM/ROCK1/PTPN11/ARHGAP5/ITGB2/VCL/VAV2/CLDN12/PIK3CA/BCAR1/VAV1/ITGAM/CLDN23/CYBB/JAM2/MMP9/NCF1/EZR/CLDN16/NCF2/ITGAL/NCF4/CD99L2/RASSF5/CLDN8/CLDN9/TXK/VCAM1/ITGA4/ICAM1	4.1154147127472
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	82/2273	232/9376	1.45795470060834	MSN/CXCR4/ITGA3/BAIAP2/ABI2/FGFR2/FGFR1/ARHGEF12/BDKRB2/GSN/RRAS2/ITGB3/ROCK2/IQGAP1/DIAPH1/NCKAP1/IQGAP2/ACTN4/LIMK2/SCIN/RRAS/MAP2K1/ITGB5/PPP1R12A/RGCC/ROCK1/ACTR3/PIP4K2C/MYLK/SOS2/ITGB2/PDGFRA/PAK2/ITGAV/VCL/ITGA2/PIP5K1A/EGFR/VAV2/SSH2/PIK3CA/PPP1R12C/ACTR3C/BCAR1/APC/PDGFA/VAV1/NCKAP1L/SRC/SPATA13/ITGAM/SSH3/ITGAX/ARAF/PDGFB/LPAR1/ARHGEF7/ITGAD/F2R/GIT1/ARHGEF1/MRAS/FGF7/FN1/SSH1/C8B/PPP1R12B/ARHGEF6/EZR/ITGAL/ITGB6/MYH14/TIAM1/LIMK1/FGF18/ITGB7/PDGFD/PIKFYVE/LPAR2/TMSB4X/ACTR3B/ITGA4	3.99542381206265
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	64/2273	173/9376	1.52599121631416	TNFSF10/HLA-DMA/HLA-DRA/DNAJC3/HLA-DMB/HLA-DRB1/MX1/IFNGR1/STAT1/CALCOCO2/HLA-DPA1/TRADD/IFNAR1/JAK1/HLA-DPB1/IFNGR2/RAB11B/EIF2AK2/MAP2K1/HLA-DQA2/TLR3/SLC25A4/NUP98/IRF7/ADAR/STAT2/FAS/TNFRSF1A/HLA-DQB1/CREBBP/TNFRSF10A/OAS1/EP300/HLA-DQA1/IL18/PIK3CA/KPNA1/TRIM25/IKBKB/OAS2/PML/HLA-DOB/CASP1/IRAK4/TNFRSF10B/MX2/NFKBIA/CXCL10/IRF9/NXF1/DNAJB1/KPNA5/HLA-DOA/TLR4/TMPRSS2/TLR7/APAF1/MAVS/BID/RSAD2/CIITA/ICAM1/JAK2/NLRX1	3.95003806774253
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	101/2273	300/9376	1.38873148555507	VEGFA/PTPRR/MAP3K5/DUSP1/IGF1/MAP4K3/TRADD/ERBB3/RPS6KA2/NTRK2/GADD45B/EFNA1/FGFR2/FGFR1/RPS6KA1/MET/MAPK14/RRAS2/RASA2/MECOM/NFATC3/IL1R1/TGFBR2/NTF3/RAP1A/IGF1R/RRAS/PPM1A/MAP2K1/ERBB2/DDIT3/DUSP4/MAX/CD14/HSPA1B/MAPKAPK2/DUSP3/FAS/TNFRSF1A/TAOK1/ELK4/MAP3K1/MAP3K3/STK4/SOS2/PDGFRA/PAK2/NF1/MAPKAPK3/ATF2/HSPA1A/MAP3K4/EGFR/STK3/MAP2K3/JUND/MAP2K4/TAOK3/JUN/CDC25B/RASGRP3/PDGFA/MAPK8IP1/IKBKB/RAPGEF2/TGFB2/MAP3K11/MAPK8IP3/ARRB2/ARAF/IRAK4/PPP3CC/PDGFB/RASGRP2/RPS6KA3/MAP2K5/PTPN7/MEF2C/MRAS/FGF7/CSF1R/TRAF6/EFNA5/EPHA2/MAP4K4/MAPK10/MAPK7/INSR/TGFBR1/DUSP16/FGF18/TAOK2/DUSP2/MAP3K9/DUSP10/PDGFD/KITLG/ARRB1/CSF1/CACNA2D4/TGFA	3.87103903313399
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	39/2273	93/9376	1.7298156479287	JAG1/HLA-DMA/HLA-DRA/HLA-DMB/HLA-DRB1/IFNGR1/STAT1/HLA-DPA1/MAPK14/JAK1/HLA-DPB1/NFATC3/IFNGR2/HLA-DQA2/HLA-DQB1/NOTCH2/STAT6/CD4/IL4R/HLA-DQA1/RBPJ/JUN/IKBKB/MAML1/HLA-DOB/PPP3CC/NFKBIA/HLA-DOA/MAML2/RUNX3/MAPK10/MAF/NOTCH1/STAT5A/CD3E/IL2RA/JAK2/CD247/LAT	4.00105865921785
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	72/2273	201/9376	1.47759224116987	PAX8/PROM1/SPINT1/KMT2A/JMJD1C/IGF1/MITF/IL1R2/GADD45B/KLF3/NCOR1/MET/CDKN1B/RUNX1/ATM/TGFBR2/JUP/IGF1R/AFF1/DDIT3/MAX/POLK/CD14/ETV6/PER2/BCL2L1/ELK4/CDKN1A/CCNT2/SUPT3H/SMAD1/DDX5/RXRB/TSPAN7/REL/BCL6/PDGFA/ITGAM/NUPR1/HPGD/KDM6A/PML/PBX3/RUNX2/SPI1/MLLT3/SP1/MEN1/MEF2C/CD86/LDB1/SIN3A/CSF1R/BIRC3/CD40/FCGR1A/TMPRSS2/MMP9/CCNT1/GZMB/ETV1/ARNT2/LYL1/PLAT/MAF/FLI1/HHEX/ITGB7/SIX1/SLC45A3/ZBTB16/RARA	3.87183377283143
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	54/2273	142/9376	1.56864105884759	HSP90B1/CYBA/GSTT1/VEGFA/BCL2/MAP3K5/DUSP1/GSTM3/MGST1/EDN1/SDC2/CALM2/IL1R2/SDC1/NFE2L2/MAPK14/ITGB3/IL1R1/PRKAA2/MGST2/MEF2A/SDC4/TNFRSF1A/CAV2/SQSTM1/ITGAV/PRKAA1/THBD/KEAP1/MAP2K4/JUN/PIK3CA/NOS3/PDGFA/IKBKB/SRC/BMPR2/PDGFB/ACVR1/GSTM4/MAP2K5/MEF2C/MMP9/NCF1/BMPR1B/NCF2/MAPK10/KLF2/MAPK7/PLAT/BMPR1A/VCAM1/ACVR2A/ICAM1	3.86235243964688
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	22/2273	44/9376	2.0624725032996	HLA-B/HLA-A/HLA-E/HLA-DMA/HLA-DRA/HLA-C/HLA-DMB/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQA2/FAS/HLA-DQB1/HLA-DQA1/HLA-F/PTPRN2/CPE/HLA-DOB/HLA-DOA/CD86/GZMB/PRF1	3.99595989907434
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	24/2273	50/9376	1.97997360316762	HLA-DMA/HLA-DRA/HLA-DMB/HLA-DRB1/PIGR/CXCR4/HLA-DPA1/HLA-DPB1/LTBR/HLA-DQA2/HLA-DQB1/ICOSLG/CCL28/TNFSF13B/HLA-DQA1/HLA-DOB/IL15RA/IL15/HLA-DOA/CD86/CD40/IL10/ITGB7/ITGA4	3.93021331743275
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	74/2273	212/9376	1.43983929475633	VEGFA/CDH1/IGF1/CALM2/EFNA1/FGFR2/FGFR1/GNAI2/MET/MAPK14/RAPGEF3/ITGB3/PARD6B/RAP1A/IGF1R/KRIT1/RAP1GAP/RRAS/TLN1/MAP2K1/SIPA1L2/RAPGEF5/SKAP1/ITGB2/PDGFRA/RGS14/MAGI1/EGFR/VAV2/PARD3/MAP2K3/PLCB4/PIK3CA/PRKCI/RALGDS/BCAR1/RASGRP3/PDGFA/VAV1/LCP2/RAPGEF2/SRC/ITGAM/PRKD1/PDGFB/ADCY6/FARP2/RASGRP2/LPAR1/F2R/MRAS/PARD6A/DOCK4/FGF7/CSF1R/APBB1IP/EFNA5/EPHA2/ITGAL/SIPA1L1/PRKD2/INSR/TIAM1/FGF18/ADCY7/RAPGEF6/RASSF5/ADCY3/PDGFD/MAGI2/LPAR2/KITLG/CSF1/LAT	3.66423961001421
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	71/2273	204/9376	1.4356426248458	VEGFA/MSN/IGF1/SDC2/STAT3/CCND1/ERBB3/GPC3/SDC1/FGFR1/ARHGEF12/CTTN/TIMP3/CD63/MET/MAPK14/RRAS2/ITGB3/ROCK2/IQGAP1/FZD6/CD44/SDC4/IGF1R/RRAS/LUM/PDPK1/HPSE/MAP2K1/ERBB2/ITGB5/PPP1R12A/ROCK1/PTPN11/FAS/CAV2/SOS2/CDKN1A/ITGAV/ITGA2/DDX5/EGFR/VAV2/PIK3CA/PPP1R12C/ITPR2/ANK3/VAV1/CAMK2D/WNT3/SRC/ITPR3/TGFB2/ARAF/FZD1/ARHGEF1/MRAS/FN1/TLR4/PPP1R12B/HBEGF/DCN/MMP9/EZR/WNT4/TIAM1/FZD5/SHH/TLR2/WNT6/FZD8	3.55858935681272
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	30/2273	70/9376	1.7678335742568	ACSL5/ACSL1/STAT3/TRADD/PRKAB1/PRKAG2/ACSL3/PRKAA2/APPL1/G6PC3/ADIPOR1/PTPN11/TNFRSF1A/LEPR/IRS2/PRKAA1/RXRB/CPT1A/PPARGC1A/ADIPOR2/IKBKB/CAMKK2/NFKBIA/IRS1/PPARA/MAPK10/CPT1B/ACACB/PCK1/JAK2	3.64753142973269
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	38/2273	95/9376	1.64997800263968	HLA-DMA/HLA-DRA/VEGFA/HLA-DMB/HLA-DRB1/ATP6V1D/ATP6AP1/ATP6V0A2/ATP6V0B/HLA-DPA1/ATP6V0A1/HLA-DPB1/HLA-DQA2/ATP6V1C1/HLA-DQB1/ATP6V1H/ITGB2/ATP6V0E2/TNFSF13B/TCIRG1/HLA-DQA1/JUN/IL18/TGFB2/ACP5/HLA-DOB/IL15/HLA-DOA/CD86/TLR4/CCL3/ITGAL/CTSK/CCL3L3/ATP6V1E2/CSF1/ICAM1/TLR2	3.60186576978409
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	21/2273	44/9376	1.96872375314962	RPN1/MAGT1/ALG2/HEXA/STT3B/RPN2/DAD1/MGAT4B/KRTCAP2/DDOST/STT3A/MAN1B1/MGAT4A/MGAT2/B4GALNT3/MAN2A1/ALG12/HEXB/B4GALT2/ALG1/ALG11	3.64337077792131
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	37/2273	93/9376	1.64110715316313	LMO7/CDH1/TJP1/BAIAP2/SMURF1/FGFR1/CTNNA1/MET/ROCK2/SMAD3/IQGAP1/ARHGAP29/TGFBR2/ACTN4/RAP1A/IGF1R/KRIT1/ERBB2/HEG1/ROCK1/PTPN1/CREBBP/SMAD4/VCL/EP300/EGFR/PARD3/SMURF2/PTPRB/PTPRJ/SRC/WAS/FARP2/PTPRM/INSR/TGFBR1/LEF1	3.51473325343173
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	45/2273	119/9376	1.559853153756	JAG1/MAP3K5/EDN1/TRADD/CFLAR/MAPK14/CREB3L1/XIAP/LIF/MAP2K1/CREB3L2/FAS/TNFRSF1A/IRF1/CYLD/JUNB/ATF2/ATF6B/ITCH/MAP2K3/MAP2K4/JUN/PIK3CA/IKBKB/ADAM17/RHBDF2/MLKL/RHBDF1/RIPK1/BCL3/BAG4/IL15/NFKBIA/CXCL10/BIRC3/DAB2IP/MMP9/TRAF5/RIPK3/MAPK10/CX3CL1/CREB3L4/VCAM1/CSF1/ICAM1	3.4767777251631
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	39/2273	100/9376	1.60872855257369	CD9/HLA-DMA/HLA-DRA/CD55/HLA-DMB/HLA-DRB1/ITGA3/IL1R2/HLA-DPA1/CD59/CSF2RA/ITGB3/HLA-DPB1/IL1R1/IL6R/CD44/HLA-DQA2/CD14/HLA-DQB1/ITGA2/CD37/CD4/IL4R/HLA-DQA1/ITGAM/HLA-DOB/HLA-DOA/CSF1R/CD33/FCGR1A/ANPEP/CD7/CD38/CD3E/CD22/KITLG/IL2RA/CSF1/ITGA4	3.4618460579112
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	106/2273	333/9376	1.3130455576562	SPP1/HLA-B/HLA-A/LAMB3/HLA-E/JAG1/HLA-C/VEGFA/TNC/LAMC1/BCAP31/MX1/ATP6V1D/ATP6AP1/ATP6V0A2/STAT1/ATP6V0B/COMP/ITGA3/PPP2R5A/CCND1/TRADD/IFNAR1/ATP6V0A1/TADA3/JAK1/ITGB3/CDKN1B/ATM/CRB3/CREB3L1/FZD6/PARD6B/LLGL2/UBE3A/RB1/RFNG/LAMA5/HES1/PPP2R3A/EIF2AK2/CHD4/MAP2K1/TLR3/ITGB5/ATP6V1C1/CREB3L2/STAT2/FAS/TNFRSF1A/NFX1/NOTCH2/ATP6V1H/IRF1/SOS2/CDKN1A/PSEN1/ATP6V0E2/RHEB/CREBBP/RBL2/ITGAV/HES4/ITGA2/PPP2R1B/EP300/MAGI1/EGFR/TCIRG1/PARD3/PTGER4/RBPJ/HLA-F/PIK3CA/PRKCI/TSC2/LAMB2/APC/IKBKB/WNT3/MAML1/DLG1/UBR4/LAMC2/MX2/IRF9/FZD1/PPP2R2D/PARD6A/FN1/MAML2/SCRIB/WNT4/COL4A4/ITGB6/MFNG/FZD5/ATR/ITGB7/NOTCH1/OASL/CREB3L4/ATP6V1E2/ITGA4/WNT6/FZD8	3.29031778747519
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	21/2273	45/9376	1.92497433641296	HLA-B/HLA-A/HLA-E/HLA-DMA/HLA-DRA/HLA-C/HLA-DMB/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQA2/FAS/HLA-DQB1/HLA-DQA1/HLA-F/HLA-DOB/HLA-DOA/CD86/GZMB/KLRC1/PRF1	3.51832775399865
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	28/2273	66/9376	1.74997666946633	HLA-DMA/HLA-DRA/HLA-DMB/HLA-DRB1/IFNGR1/STAT1/STAT3/HLA-DPA1/RORC/SMAD3/HLA-DPB1/IFNGR2/HLA-DQA2/HLA-DQB1/STAT6/IL4R/HLA-DQA1/JUN/IL18/TGFB2/HLA-DOB/TLR5/RORA/HLA-DOA/TLR4/IL10/MAF/TLR2	3.45867161278643
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	73/2273	216/9376	1.39407863648955	TNFSF10/HSP90B1/CYBA/BCL2/MAP3K5/SOD2/HSPA5/STAT3/ERN1/CALM2/ABCG1/NFE2L2/MAPK14/ROCK2/NFATC3/XBP1/RAP1A/PDPK1/DDIT3/ATF6/IRF7/CD14/HSPA1B/FAS/TNFRSF1A/BCL2L1/LY96/LBP/TNFRSF10A/CYP2J2/HSPA1A/VAV2/RXRB/MAP2K3/PLCB4/MAP2K4/JUN/IL18/ABCA1/PIK3CA/NOS3/VAV1/CAMK2D/IKBKB/MIB2/SRC/CASP1/EIF2AK3/CYBB/IRAK4/PPP3CC/TNFRSF10B/NFKBIA/ARHGEF1/TLR4/CD40/TRAF6/MMP9/NCF1/APAF1/CCL3/NCF2/MAPK10/NCF4/BID/VLDLR/TIRAP/POU2F2/VCAM1/CCL3L3/ICAM1/JAK2/TLR2	3.31456453578471
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	52/2273	144/9376	1.48956347460527	MAP3K5/C1QA/C1QB/CCND1/TRADD/LPIN3/PRKAB1/MAPK14/PRKAG2/PRKAA2/C1QC/ALDH9A1/CD14/ADIPOR1/FAS/TNFRSF1A/MLYCD/LY96/LBP/LPIN2/TRA2B/C2/PRKAA1/C3/MAP2K3/CPT1A/MAP2K4/PPARGC1A/IL17RC/C3AR1/ADIPOR2/SIRT1/IKBKB/CAMKK2/IRAK4/RIPK1/LPIN1/NFKBIA/ACACA/TLR4/TRAF6/ACOX3/C5AR1/PPARA/MAPK10/CPT1B/ACACB/SREBF1/IL17RA/LEF1/TIRAP/NOX4	3.34893567088188
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	11/2273	18/9376	2.52079972625507	FUCA1/FUCA2/NEU1/HEXA/GLB1/HEXB/GBA2/AGA/MAN2C1/MANBA/MAN2B2	3.65326525564037
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	17/2273	34/9376	2.0624725032996	RORC/PRKAB1/PRKAG2/PRKAA2/CRY2/CSNK1D/FBXW11/FBXL3/PER2/BHLHE41/PRKAA1/CSNK1E/NR1D2/CLOCK/RORA/PER3/PER1	3.5107643133278
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	45/2273	122/9376	1.52149610899151	RAB2A/IGF1/PPP2R5A/CCND1/PRKAB1/TBC1D1/PRKAG2/CREB3L1/FBP1/PRKAA2/RAB11B/RAB10/PPP2R3A/IGF1R/PDPK1/G6PC3/ADIPOR1/CREB3L2/HMGCR/PFKP/MLYCD/LEPR/RHEB/PPP2R1B/IRS2/PRKAA1/CPT1A/PPARGC1A/PIK3CA/TSC2/ADIPOR2/SIRT1/CAMKK2/PFKFB2/PPP2R2D/ACACA/IRS1/LIPE/CPT1B/INSR/ACACB/PFKFB3/SREBF1/PCK1/CREB3L4	3.27967409023069
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/2273	21/9376	2.3571114323424	CSGALNACT1/CHPF/B3GAT3/B3GALT6/CHST3/CSGALNACT2/DSE/CHST12/CHPF2/CHST15/CHST7/CHST14	3.52182449060038
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	41/2273	110/9376	1.5374795024597	SMURF1/NCOR1/INHBB/SMAD3/TGFBR2/TGIF1/SKIL/ROCK1/ACVR1B/THSD4/CREBBP/SMAD4/PPP2R1B/SMAD1/EP300/NOG/HAMP/SMURF2/FBN1/NEO1/BMPR2/TGFB2/LEMD3/ACVR1/LEFTY1/CHRD/SP1/CDKN2B/LEFTY2/SIN3A/TMEM53/DCN/BMPR1B/RGMB/SKI/EMP3/TGFBR1/HFE/BMPR1A/ACVR2A/FMOD	3.20757300539363
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	49/2273	137/9376	1.4753452943311	TNFSF10/CTSB/CTSD/BCL2/MAP3K5/CTSS/CTSH/CTSZ/ERN1/PARP4/CAPN2/TRADD/GADD45B/CFLAR/ATM/CTSC/XIAP/MCL1/PDPK1/MAP2K1/DDIT3/FAS/TNFRSF1A/BCL2L1/CTSO/TNFRSF10A/SPTAN1/BCL2L11/JUN/PIK3CA/ITPR2/IKBKB/ITPR3/PARP3/EIF2AK3/RIPK1/CTSW/TNFRSF10B/NFKBIA/PTPN13/BIRC3/DAB2IP/GZMB/APAF1/MAPK10/BID/CTSK/CTSF/PRF1	3.17045393666083
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	49/2273	138/9376	1.46465438640117	ARHGEF28/PKN2/BAIAP2/RPS6KA2/ARHGEF12/RPS6KA1/MAPK14/ROCK2/NFATC3/MAP2K1/ROCK1/WIPF2/ACTR3/PIP5K1A/FCGR2A/VAV2/CD4/MAP2K3/MAP2K4/JUN/IL18/PIK3CA/ACTR3C/BCAR1/WIPF1/RHOG/VAV1/LCP2/IKBKB/SRC/CASP1/WAS/IRAK4/GIT2/NFKBIA/RPS6KA3/ARHGEF7/ARHGEF1/FN1/TLR4/TRAF6/MAPK10/IL10/LIMK1/ELMO2/WIPF3/ACTR3B/ITGA4/LAT	3.1106063503109
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	42/2273	115/9376	1.50650165458406	SLC34A2/BCL2/FGFR1/CYP24A1/SGK1/GNAI2/CREB3L1/AKAP13/MEF2A/MAP2K1/WNK1/CREB3L2/CDKN1A/ATF2/ATF6B/EGFR/RXRB/MAFB/PLCB4/JUND/ITPR2/NR4A2/MMP24/MEF2D/ITPR3/RUNX2/STK39/ARRB2/ARAF/GNA11/ADCY6/SP1/MEF2C/PDE4B/ARHGEF1/HBEGF/ADCY7/PLD2/ADCY3/CREB3L4/ARRB1/ARHGEF11	3.09147184221742
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	54/2273	156/9376	1.42786557920742	CLDN10/CD81/CLDN3/CLDN4/CLDN1/MX1/STAT1/STAT3/YWHAH/CCND1/TRADD/IFNAR1/CLDN7/CFLAR/JAK1/RB1/EIF2AK2/MAP2K1/TLR3/IRF7/OCLN/STAT2/FAS/TNFRSF1A/SOS2/CDKN1A/PIAS1/OAS1/PPP2R1B/EGFR/IFIT1/CLDN12/PIK3CA/IKBKB/OAS2/CLDN23/ARAF/RIPK1/MX2/NFKBIA/CXCL10/IRF9/PPP2R2D/SCARB1/TRAF6/APAF1/CLDN16/PPARA/MAVS/BID/RSAD2/NR1H3/CLDN8/CLDN9	3.04837672672577
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	40/2273	109/9376	1.5137412868254	STAT3/RPS6KA2/PRKAB1/RPS6KA1/PRKAG2/GFPT1/CREB3L1/PRKAA2/SLC27A4/PDPK1/G6PC3/CREB3L2/PTPN11/PTPN1/TNFRSF1A/PYGL/OGT/IRS2/PRKAA1/CPT1A/PPARGC1A/SLC27A3/PIK3CA/MLXIP/NOS3/IKBKB/NFKBIA/RPS6KA3/IRS1/PPARA/MAPK10/CPT1B/INSR/ACACB/SREBF1/PPP1R3D/NR1H3/PCK1/SLC27A1/CREB3L4	3.05177552291141
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	74/2273	227/9376	1.34469572902353	HLA-B/HLA-A/B2M/HLA-E/HLA-C/VEGFA/PDIA3/CXCR4/STAT3/CALM2/CCND1/TRADD/ARHGEF12/TAPBP/GNAI2/MAPK14/JAK1/ITGB3/ROCK2/CREB3L1/AKAP13/TAPBPL/NFATC3/IL1R1/IL6R/RB1/MAP2K1/TAP1/CREB3L2/ROCK1/FAS/TNFRSF1A/SOS2/CDKN1A/PDGFRA/RHEB/ITGAV/PTGER2/GNG11/ATF2/CALR/ATF6B/EGFR/PTGER4/PLCB4/HLA-F/PIK3CA/ITPR2/TSC2/BCAR1/IKBKB/SRC/ITPR3/PPP3CC/RIPK1/CDKN2A/GNA11/ADCY6/NFKBIA/SP1/CCL4/ARHGEF1/CCL3/PTGER3/TRAF5/CX3CL1/GNG7/BID/ADCY7/ADCY3/CREB3L4/CCL3L3/ARHGEF11/GNG4	2.97390071840656
NA	NA	hsa04518	Integrin signaling	53/2273	154/9376	1.41962393084258	SPP1/LAMB3/VEGFA/TNC/LAMC1/CDH1/IGF1/COMP/ITGA3/CCND1/MET/ITGB3/FLNB/ACTN4/LAMA5/IGF1R/TLN1/ERBB2/ITGB5/LIMS1/ITGB2/PDGFRA/ITGAV/VCL/ITGA2/C3/EGFR/PARVG/PIK3CA/LAMB2/FREM2/PDGFA/FBN1/SRC/ITGAM/FERMT3/ITGAX/LAMC2/PDGFB/ICAM3/ITGAD/FN1/ARHGEF6/PARVB/COL4A4/ITGAL/ITGB6/ITGB7/PDGFD/ICAM2/VCAM1/ITGA4/ICAM1	2.97010975327711
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	21/2273	49/9376	1.7678335742568	GALNT15/GALNT3/ST6GAL1/GALNT11/C1GALT1C1/GALNT7/PLOD3/RFNG/EOGT/GALNT9/OGT/B4GALT2/POFUT2/POMT1/GXYLT2/POMT2/GALNT10/MFNG/FUT10/GALNT6/XXYLT1	3.04830626382687
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	79/2273	248/9376	1.31399457871507	TNFSF10/HSP90B1/BCL2/DYNC2LI1/GCC2/VPS41/RHOB/TRADD/M6PR/RAB9A/MAPK14/CYTH2/ROCK2/PODXL/DYNC1H1/AHNAK/ARL8A/ARF1/MYO6/NCKAP1/SNX9/KPNA4/RAB5B/RRAS/MAP2K1/CD14/ACBD3/DYNC1LI1/TNFRSF1A/LY96/ACTR3/ABI1/EXOC7/TNFRSF10A/KPNA3/PLEKHM2/PTPRC/MAP2K3/MAP2K4/JUN/IL18/PIK3CA/KPNA1/ACTR3C/PLEKHM1/RHOG/PIK3C3/NCKAP1L/IKBKB/DYNC1I1/CASP1/DYNC2H1/IRAK4/MLKL/CYTH1/CYTH4/RIPK1/TNFRSF10B/TLR5/NFKBIA/EXOC2/NAIP/FYCO1/KLC1/BIRC3/TLR4/TRAF6/VPS33A/AHNAK2/RIPK3/KLC4/MAPK10/KLC3/ELMO2/LEF1/TIRAP/ACTR3B/SNX33/TLR2	2.83481435473411
Human Diseases	Immune disease	hsa05310	Asthma	15/2273	32/9376	1.93356797184338	HLA-DMA/HLA-DRA/HLA-DMB/HLA-DRB1/HLA-DPA1/PRG2/HLA-DPB1/HLA-DQA2/HLA-DQB1/FCER1G/HLA-DQA1/HLA-DOB/HLA-DOA/CD40/IL10	2.99239531994334
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	37/2273	103/9376	1.48177636159389	C1QA/C1QB/IFNGR1/BDKRB2/CFLAR/GNAI2/MAPK14/IFNGR2/TGFBR2/C1QC/FAS/TNFRSF1A/SERPINE1/CALR/PPP2R1B/C3/PLCB4/MAP2K4/JUN/PIK3CA/GNA15/IKBKB/TGFB2/IRAK4/GNA11/NFKBIA/PPP2R2D/TLR4/TRAF6/CCL3/MAPK10/IL10/TGFBR1/CD3E/CCL3L3/CD247/TLR2	2.7811116138099
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	31/2273	83/9376	1.5406421108985	ACSL5/SOD2/ACSL1/CAT/ACSL3/HSD17B4/GSTK1/PEX2/PEX3/PEX13/PEX10/PHYH/MLYCD/PEX1/ABCD4/MPV17L2/ACOT8/DHRS4/PEX11B/PECR/PEX19/SLC25A17/PEX14/MVK/PEX11G/ACOX3/PEX11A/PEX6/DECR2/PEX12/MPV17L	2.79856498762526
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	22/2273	54/9376	1.68053315083671	HLA-B/HLA-A/HLA-E/HLA-DMA/HLA-DRA/HLA-C/HLA-DMB/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQA2/FAS/HLA-DQB1/HLA-DQA1/HLA-F/HLA-DOB/HLA-DOA/CD86/CD40/GZMB/IL10/PRF1	2.83697863511258
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	21/2273	51/9376	1.6985067674232	ATP6V1D/ATP6AP1/PDIA4/ATP6V0A2/TJP1/ATP6V0B/SEC61A1/ATP6V0A1/KDELR1/ARF1/SLC12A2/ATP6V1C1/TJP2/ATP6V1H/ATP6V0E2/KDELR3/KDELR2/TCIRG1/KCNQ1/ADCY3/ATP6V1E2	2.82940902604542
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	43/2273	125/9376	1.41898108227013	ASAH1/CTSD/DEGS1/CERS2/BCL2/MAP3K5/ORMDL2/SMPD1/PPP2R5A/ORMDL1/TRADD/BDKRB2/GNAI2/MAPK14/ROCK2/SPTLC2/SGPL1/SPTLC3/PPP2R3A/SGMS2/SPTLC1/PDPK1/MAP2K1/ROCK1/TNFRSF1A/FCER1G/SPHK1/SGMS1/PPP2R1B/CERS6/PLCB4/SGPP2/PIK3CA/NOS3/SMPD2/PPP2R2D/CERS4/MAPK10/BID/NSMAF/PLD2/S1PR4/SPHK2	2.66759275359067
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	32/2273	88/9376	1.49998000239971	SERPING1/CLU/CD55/CD46/CFI/C1QA/C1QB/CD59/BDKRB2/C1QC/C4BPA/ITGB2/A2M/CFH/SERPINE1/C2/C3/THBD/VSIG4/SERPINA1/C3AR1/F3/ITGAM/ITGAX/F2R/MASP1/C8B/C5AR1/PLAT/C4BPB/F13A1/SERPINE2	2.66561433789092
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	29/2273	78/9376	1.53363339988945	ALDH6A1/CDIPT/IMPA2/SACM1L/PPIP5K2/ITPK1/PIP4K2C/MTMR14/PIP5K1A/MINPP1/PLCB4/PIK3CA/PIK3C3/PLCD3/INPP5K/INPP4B/IMPA1/INPP1/ITPKC/PI4K2A/MTM1/IPMK/INPP5D/MTMR3/INPP4A/OCRL/INPP5E/PIKFYVE/FIG4	2.67707157773789
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	28/2273	75/9376	1.53997946913037	BCL2/IGF1/CCND1/GADD45B/ATM/CD82/MDM4/FAS/CHEK2/BCL2L1/CDKN1A/SERPINE1/TNFRSF10A/RCHY1/TSC2/SESN3/CDKN2A/TNFRSF10B/GORAB/PPP1R13L/RRM2B/SESN2/APAF1/PERP/BID/ATR/STEAP3/PPM1D	2.65587423501352
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	37/2273	106/9376	1.43983929475633	HSP90B1/BCL2/SPINT1/IGF1/CCND1/IL1R2/FGFR2/FGFR1/CDKN1B/CREB3L1/FOLR1/RB1/IGF1R/PDPK1/MAP2K1/ERBB2/CREB3L2/FOLR2/SOS2/CDKN1A/PDGFRA/CREBBP/EP300/EGFR/PIK3CA/PDGFA/IKBKB/ARAF/PDGFB/NFKBIA/TMPRSS2/MMP9/PLAT/PDGFD/LEF1/CREB3L4/TGFA	2.57615233473025
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	22/2273	56/9376	1.6205141097354	EVC/BCL2/KIF3A/CCND1/SMURF1/BOC/CUL3/CSNK1D/FBXW11/IQCE/CSNK1G3/SMURF2/CSNK1E/DISP1/ARRB2/GAS1/EVC2/EFCAB7/SUFU/SCUBE2/SHH/ARRB1	2.63452404890806
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	64/2273	203/9376	1.3004752730165	SPP1/LAMB3/VEGFA/BCL2/TNC/LAMC1/IGF1/CAPN2/COMP/ITGA3/CCND1/MET/ITGB3/ROCK2/XIAP/FLNB/DIAPH1/ACTN4/RAP1A/LAMA5/IGF1R/TLN1/PDPK1/MAP2K1/ERBB2/ITGB5/PPP1R12A/ROCK1/CAV2/ARHGAP5/MYLK/SOS2/PDGFRA/PAK2/ITGAV/VCL/ITGA2/PIP5K1A/EGFR/VAV2/EMP2/JUN/ZYX/PARVG/PIK3CA/PPP1R12C/LAMB2/BCAR1/PDGFA/VAV1/SRC/LAMC2/PDGFB/SHC4/FN1/BIRC3/PPP1R12B/PARVB/COL4A4/ITGB6/MAPK10/ITGB7/PDGFD/ITGA4	2.44830494293717
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	29/2273	80/9376	1.49529256489221	VEGFA/BCL2/IGF1/STAT3/ERBB3/FGFR2/MET/JAK1/GAS6/IL6R/IGF1R/MAP2K1/ERBB2/BCL2L1/SOS2/PDGFRA/NF1/BCL2L11/EGFR/PIK3CA/PDGFA/AXL/SRC/ARAF/PDGFB/SHC4/PDGFD/TGFA/JAK2	2.51665215868467
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	36/2273	104/9376	1.42786557920742	AGPAT5/CRLS1/LPIN3/LYPLA2/CDS1/GPCPD1/LPCAT3/PLD3/CDIPT/PISD/LPCAT1/PLA2G15/SGMS2/AGPAT3/ETNK1/SGMS1/LPIN2/CHKA/LPGAT1/CDS2/CEPT1/MBOAT7/DGKH/CHKB/LCLAT1/MBOAT1/PEMT/AGPAT2/LPIN1/DGKE/GPD2/PGS1/PNPLA6/SAMD8/PLD2/PLA2G6	2.48199988365121
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	10/2273	20/9376	2.0624725032996	LBR/DHCR24/SC5D/CYP24A1/LIPA/CYP51A1/MSMO1/SOAT1/NSDHL/HSD17B7	2.69061797578768
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	51/2273	157/9376	1.3399502887679	HLA-B/HLA-A/HLA-E/HLA-C/CALM2/CAPN2/CCND1/RAD50/GADD45B/NBN/MAPK14/RRAS2/SMAD3/ATM/NFATC3/TGFBR2/RBBP4/RB1/FBXW11/HIPK2/RRAS/MAP2K1/SLC25A4/MAPKAPK2/CHEK2/HIPK3/SQSTM1/CDKN1A/RHEB/RBL2/SERPINE1/MAP2K3/HLA-F/PIK3CA/ITPR2/TSC2/SIRT1/ITPR3/TGFB2/PPP3CC/CDKN2A/CDKN2B/LIN52/TRPM7/ETS1/MRAS/RAD9A/HIPK1/TGFBR1/ATR/RASSF5	2.42989653572187
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	26/2273	71/9376	1.51054324185323	ATP6V1D/ATP6AP1/ATP6V0A2/TJP1/ATP6V0B/ATP6V0A1/MET/MAPK14/ATP6V1C1/ADAM10/PTPN11/ATP6V1H/ATP6V0E2/EGFR/TCIRG1/MAP2K4/JUN/IKBKB/ADAM17/SRC/NFKBIA/GIT1/JAM2/HBEGF/MAPK10/ATP6V1E2	2.44268781552316
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	37/2273	109/9376	1.40021069031349	SPP1/STAT1/IFNAR1/MAPK14/JAK1/MAP2K1/TLR3/IRF7/CD14/STAT2/LY96/LBP/TLR1/MAP2K3/MAP2K4/JUN/PIK3CA/IKBKB/IRAK4/RIPK1/TLR5/NFKBIA/CXCL10/CCL4/IRF9/CD86/TLR4/CD40/TRAF6/TLR7/CCL3/IRF5/MAPK10/CTSK/TIRAP/CCL3L3/TLR2	2.37737012778046
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	31/2273	90/9376	1.42081439116195	SOD2/IGF1/CAT/PRKAB1/PRKAG2/CREB3L1/PRKAA2/IGF1R/APPL1/ADIPOR1/CREB3L2/RB1CC1/RHEB/ATF2/ATF6B/IRS2/PRKAA1/PPARGC1A/PIK3CA/TSC2/ADIPOR2/SIRT1/SESN3/CAMKK2/ADCY6/SESN2/IRS1/INSR/ADCY7/ADCY3/CREB3L4	2.26914342645748
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	27/2273	77/9376	1.44640928802829	VEGFA/STAT1/STAT3/CCND1/GADD45B/JAK1/SMAD3/TGFBR2/RB1/MAP2K1/ERBB2/POLK/BCL2L1/CDKN1A/SMAD4/EGFR/PIK3CA/RALGDS/IKBKB/TGFB2/ARAF/CDKN2A/ARHGEF6/MAPK10/TGFBR1/PLD2/TGFA	2.22497384149564
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	35/2273	105/9376	1.3749816688664	BCL2/TRADD/GADD45B/CFLAR/ATM/XIAP/LTBR/IL1R1/CD14/TNFRSF1A/BCL2L1/LY96/CYLD/LBP/TNFSF13B/TRIM25/IKBKB/ERC1/IRAK4/SYK/RIPK1/MALT1/NFKBIA/CCL4/PPP1R13L/BIRC3/TLR4/CD40/EDA/TRAF6/TRAF5/TIRAP/VCAM1/ICAM1/LAT	2.18577696754246
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	51/2273	163/9376	1.29062696525497	BCL2/ATP6AP1/STAT1/STAT3/IFNAR1/MAPK14/JAK1/SMAD3/CREB3L1/NFATC3/TGFBR2/RB1/MAP2K1/TLR3/IRF7/CREB3L2/STAT2/FAS/MAP3K1/SOS2/CDKN1A/CREBBP/SMAD4/ATF2/ATF6B/STAT6/EP300/MAP2K3/MAP2K4/JUN/PIK3CA/IKBKB/SRC/TGFB2/ARAF/IRAK4/NFKBIA/EGR2/TLR4/TRAF6/MMP9/APAF1/MAPK10/MAVS/TGFBR1/BID/STAT5A/TIRAP/CREB3L4/JAK2/TLR2	2.11735472469726
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	16/2273	41/9376	1.60973463672164	VEGFA/CDH1/DAPK1/CCND1/RB1/MAP2K1/ERBB2/CDKN1A/TYMP/EGFR/SRC/ARAF/CDKN2A/HBEGF/MMP9/DAPK2	2.21329897195128
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	33/2273	99/9376	1.3749816688664	DEFB1/HLA-DMA/HLA-DRA/HLA-DMB/CFI/C1QA/HLA-DRB1/C1QB/HLA-DPA1/HLA-DPB1/C1QC/FCGR3A/HLA-DQA2/HLA-DQB1/ITGB2/CFH/C2/FCGR2A/C3/HLA-DQA1/C3AR1/FPR3/ITGAM/SELPLG/HLA-DOB/HLA-DOA/MASP1/FCGR1A/ITGAL/C5AR1/IL10/PTAFR/ICAM1	2.1217211486189
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	19/2273	52/9376	1.50719144471894	CYP27A1/APOE/NCEH1/LRPAP1/LIPA/APOC1/PLTP/STARD3NL/SOAT1/SORT1/TSPO/LIPC/ABCA1/NPC1/NPC2/SCARB1/LPL/OSBPL5/CIDEB	2.07461210402945
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	28/2273	83/9376	1.39154771306961	PHC2/RBBP4/PHF1/UBE2D1/EZH1/MAX/CREBBP/OGT/SCMH1/ASXL2/EP300/KDM2A/CBX6/LCOR/CBX7/BCOR/PHC3/PCGF2/MBD6/L3MBTL4/E2F6/FOXK1/MGA/SFMBT2/L3MBTL3/SCML1/CBX8/MBD5	2.0267968378569
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	103/2273	362/9376	1.17367219801027	SPP1/LAMB3/HSP90B1/VEGFA/BCL2/TNC/LAMC1/IGF1/YWHAH/PKN2/COMP/ITGA3/PPP2R5A/CCND1/IFNAR1/ERBB3/NTRK2/EFNA1/FGFR2/FGFR1/SGK1/MET/JAK1/ITGB3/CDKN1B/CREB3L1/PRKAA2/IL6R/NTF3/LAMA5/MCL1/PPP2R3A/IGF1R/PDPK1/MAP2K1/ERBB2/CSH1/G6PC3/ITGB5/CREB3L2/BCL2L1/SOS2/CDKN1A/PDGFRA/RHEB/RBL2/ITGAV/OSMR/GNG11/ITGA2/ATF2/PPP2R1B/ATF6B/PRKAA1/BCL2L11/MAGI1/EGFR/IL4R/PIK3CA/TSC2/LAMB2/NOS3/PDGFA/IKBKB/SGK3/LAMC2/SYK/PDGFB/LPAR1/PPP2R2D/F2R/FGF7/FN1/IRS1/CSF1R/TLR4/EFNA5/EPHA2/LPAR6/COL4A4/ITGB6/OSM/GNG7/PIK3AP1/INSR/PRL/FGF18/PRLR/ITGB7/PCK1/PDGFD/MAGI2/CREB3L4/LPAR2/KITLG/IL2RA/GNG4/CSF1/ITGA4/TGFA/JAK2/TLR2/PHLPP2	1.90629565466927
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	59/2273	196/9376	1.24169262953752	HLA-B/HLA-A/HLA-E/HLA-C/VEGFA/IFNGR1/STAT1/STAT3/CALM2/CCND1/TRADD/IFNAR1/MAPK14/IL6ST/JAK1/NFATC3/RB1/EIF2AK2/MAP2K1/TLR3/IRF7/MAPKAPK2/STAT2/CLEC2B/FAS/TNFRSF1A/ZFP36/CDKN1A/CREBBP/GNG11/EP300/MICA/C3/MAP2K4/JUN/HLA-F/PIK3CA/ITPR2/PIK3C3/IKBKB/SRC/ITPR3/ATG14/RCAN1/SYK/PPP3CC/PDGFB/NFKBIA/IRF9/CD86/HCK/MAPK10/GNG7/BID/LEF1/CD200R1/GNG4/ICAM1/JAK2	1.93434774052855
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	25/2273	73/9376	1.41265239952028	MX1/CXCR4/AFF4/VPS4B/SERINC3/TSG101/PDCD6IP/RANBP2/VPS4A/SAMHD1/BST2/CCNT2/CREBBP/APOBEC3G/EP300/CD4/SUPT5H/CPSF7/SERINC5/ELL2/MDFIC/MLLT3/MX2/BICD1/CCNT1	2.00215982721574
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	34/2273	105/9376	1.33569647832736	GABARAPL1/MITF/CALCOCO2/SMURF1/NBR1/RRAS2/CITED2/GABARAPL2/TBC1D15/TAX1BP1/OPTN/RAB5B/RRAS/AMFR/USP8/CCZ1/BCL2L1/MFN1/PINK1/SQSTM1/MUL1/SMURF2/JUN/RHOT2/OPA1/SRC/EIF2AK3/ATG9A/SP1/MRAS/ATG9B/MAPK10/USP30/NLRX1	1.95678266788686
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	34/2273	105/9376	1.33569647832736	STAT1/CALM2/ARHGEF12/MAPK14/RRAS2/NFATC3/RRAS/MAPKAPK2/STAT2/PTPN11/FCER1G/IRF1/CYLD/JUN/PIK3CA/ITPR2/LSP1/PLK3/IKBKB/SRC/ITPR3/CASP1/SYK/PPP3CC/MALT1/BCL3/NFKBIA/IRF9/EGR2/KSR1/MRAS/MAPK10/IL10/CARD9	1.95678266788686
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	32/2273	98/9376	1.34692081848137	CALM2/CDS1/CDIPT/IMPA2/SACM1L/PPIP5K2/ITPK1/PIP4K2C/CDS2/MTMR14/PIP5K1A/DGKH/PLCB4/PIK3CA/ITPR2/PIK3C3/PLCD3/INPP4B/ITPR3/IMPA1/INPP1/DGKE/ITPKC/PI4K2A/MTM1/IPMK/INPP5D/MTMR3/INPP4A/OCRL/INPP5E/PIKFYVE	1.95290296515032
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	22/2273	63/9376	1.44045698643147	KMT2A/ACAT1/KMT2E/MECOM/ASH1L/PLOD3/NSD1/HADHA/DHTKD1/ALDH9A1/PHYKPL/PRDM2/EZH1/KMT2B/SETD2/DLST/KMT2C/SETD1B/TMLHE/KMT2D/SETD1A/SETDB1	1.98423645807856
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	38/2273	120/9376	1.30623258542308	BCL2/MAP3K5/CALM2/RPS6KA2/NTRK2/RPS6KA1/MAPK14/NTF3/KIDINS220/RAP1A/PDPK1/MAP2K1/MAPKAPK2/PTPN11/MAP3K1/MAP3K3/SOS2/PSEN1/SORT1/JUN/PIK3CA/ZNF274/CAMK2D/IKBKB/SH2B1/IRAK4/PRDM4/NFKBIA/RPS6KA3/SHC4/MAP2K5/IRS1/TRAF6/PSEN2/MAPK10/MAPK7/SH2B3/IRAK3	1.90983039012972
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	44/2273	142/9376	1.27815197387581	SMURF1/UBE2L6/CUL3/UBE2R2/XIAP/UBE2W/UBE3A/FBXW11/WWP1/CUL5/UBE2D1/BIRC6/UBR5/TRIP12/UBE2G1/HERC2/UBA6/MAP3K1/SYVN1/PIAS1/NEDD4L/UBE2G2/UBE2E2/UBE4A/HERC4/RCHY1/ITCH/KEAP1/SMURF2/UBA3/PIAS3/UBE2O/UBE3B/HERC1/PML/RHOBTB2/CUL7/UBE4B/KLHL9/BIRC3/TRAF6/UBA7/PPIL2/UBOX5	1.88927784614967
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	25/2273	75/9376	1.3749816688664	GSTT1/BCL2/MAP3K5/GSTM3/MGST1/ATM/XIAP/MGST2/SLC31A1/PDPK1/ERBB2/FAS/BCL2L1/CDKN1A/PIK3CA/TOP2B/REV3L/MSH3/CDKN2A/GSTM4/BIRC3/APAF1/BID/POLH/ATP7A	1.84433707183079
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	8/2273	18/9376	1.83330889182187	LMBRD1/MTR/CD320/ABCD4/THAP11/MMAA/TCN2/MTRR	2.00177470389577
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	30/2273	93/9376	1.33062742148362	LAMB3/BCL2/LAMC1/ITGA3/CCND1/GADD45B/CDKN1B/XIAP/RB1/LAMA5/MAX/POLK/BCL2L1/CDKN1A/ITGAV/ITGA2/RXRB/PIK3CA/LAMB2/IKBKB/LAMC2/NFKBIA/FHIT/CDKN2B/FN1/BIRC3/TRAF6/APAF1/TRAF5/COL4A4	1.81259433318033
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	41/2273	133/9376	1.27159958850051	HLA-B/HLA-A/TNFSF10/HLA-E/HLA-C/IFNGR1/IFNAR1/TYROBP/IFNGR2/FCGR3A/MAP2K1/PTPN11/FAS/FCER1G/SOS2/ITGB2/TNFRSF10A/MICA/VAV2/PIK3CA/VAV1/LCP2/ARAF/HCST/SYK/PPP3CC/TNFRSF10B/LAT2/SHC4/SH3BP2/GZMB/ITGAL/KLRC2/CD48/KLRC1/BID/ICAM2/PRF1/ICAM1/CD247/LAT	1.7844849941749
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/2273	31/9376	1.59675290578034	SEC11C/SEC63/SEC62/HSPA5/TMEM208/SEC61A1/SRPRB/SPCS2/SRP54/IMMP2L/SPCS1/SGTA	1.88256588869124
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	50/2273	168/9376	1.227662204345	BCL2/IFNGR1/IL20RA/STAT1/STAT3/CCND1/IFNAR1/IL13RA1/CSF2RA/IL6ST/JAK1/IFNGR2/IL6R/LIF/MCL1/CSH1/STAT2/STAM2/PTPN11/BCL2L1/SOS2/CDKN1A/LEPR/PDGFRA/CREBBP/PIAS1/OSMR/CISH/FHL1/STAT6/EP300/EGFR/CLCF1/IL4R/PIK3CA/PIAS3/PDGFA/IL15RA/PDGFB/IL15/IRF9/OSM/IL10/PRL/PRLR/SOCS5/CTF1/STAT5A/IL2RA/JAK2	1.68433072462753
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	16/2273	45/9376	1.4666471134575	DEFB1/ABCC3/ABCG1/ABCA6/ABCA4/ABCC5/ABCA5/TAP1/ABCD4/ABCC4/ABCA1/ABCA9/ABCB8/ABCA8/ABCB7/ABCA3	1.77498707366067
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	55/2273	187/9376	1.213219119588	CYBA/CTSB/GABARAPL1/BCL2/STAT1/PKN2/IFI16/IFNAR1/MAPK14/JAK1/GABARAPL2/XIAP/TXNIP/GBP3/IRF7/STAT2/BCL2L1/MFN1/GPSM3/TP53BP1/OAS1/NAMPT/ANTXR2/PLCB4/JUN/IL18/ITPR2/IKBKB/GBP2/OAS2/ITPR3/CARD16/CASP1/CYBB/IRAK4/RIPK1/ANTXR1/NFKBIA/IRF9/TRPM7/NAIP/BIRC3/TLR4/TRPV2/TRAF6/TRAF5/RIPK3/GBP4/MAPK10/MAVS/PSTPIP1/P2RX7/CARD9/GBP5/NLRX1	1.66600872684024
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	19/2273	56/9376	1.3995349129533	SAR1B/ARF1/CD14/HSPA1B/CLK1/ITGB2/RAB1B/HSPA1A/C3/IL18/ITGAM/CASP1/TLR5/CLK4/NFKBIA/NAIP/TLR4/APAF1/TLR2	1.69631007585421
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	31/2273	99/9376	1.29164944651086	JAG1/BCL2/IGF1/CCND1/NCOR1/MAPK14/CDKN1B/NCOA3/RB1/IGF1R/MAP2K1/ERBB2/NOTCH2/SOS2/CDKN1A/EGFR/JUN/PIK3CA/SRC/ARAF/CDKN2A/ADCY6/SP1/SHC4/MED1/HBEGF/MMP9/MAPK10/ADCY7/NOTCH1/ADCY3	1.65021079701248
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	12/2273	32/9376	1.5468543774747	GABARAPL1/GABARAPL2/WIPI1/WIPI2/ATG4D/PIK3C3/ULK2/ATG9A/ATG7/ATG9B/ATG2A/ATG2B	1.75284985046634
Human Diseases	Infectious disease: viral	hsa05162	Measles	41/2273	136/9376	1.2435495975777	CD46/BCL2/MSN/MX1/STAT1/STAT3/CCND1/TRADD/IFNAR1/RAB9A/JAK1/CDKN1B/EIF2AK2/IRF7/HSPA1B/ADAR/STAT2/FAS/BCL2L1/OAS1/HSPA1A/RCHY1/JUN/PIK3CA/IKBKB/OAS2/IRAK4/MX2/NFKBIA/IRF9/TLR4/TRAF6/TLR7/APAF1/MAPK10/MAVS/BID/STAT5A/CD3E/IL2RA/TLR2	1.61839800204672
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	11/2273	29/9376	1.56463431284798	MOB1A/WWC1/SAV1/NF2/STK3/LATS2/RASSF6/CSNK1E/RASSF4/WTIP/RASSF2	1.72264026038229
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	25/2273	78/9376	1.32209775852539	SERPING1/C1QA/C1QB/CALM2/GNAI2/MAPK14/C1QC/CD14/C4BPA/LY96/IRF1/ITGB2/C2/C3/JUN/IRF8/ITGAM/CASP1/IRAK4/TLR4/TRAF6/MAPK10/IL10/C4BPB/TIRAP	1.61586353998837
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/2273	57/9376	1.3749816688664	ACSL5/ACSL1/ACAT1/ELOVL1/ACAA2/ACSL3/HSD17B4/ELOVL7/HSD17B12/HADHA/PPT1/TECR/CPT2/MCAT/CPT1A/ACSF3/ACACA/ACOX3/CPT1B	1.60630221518572
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	24/2273	75/9376	1.31998240211175	HSP90B1/GPX3/PAX8/ATP1B1/PDIA4/HSPA5/ATP1A1/CANX/CREB3L1/GPX1/CREB3L2/ATF2/ATF6B/IYD/TTF1/GPX7/PLCB4/ITPR2/ITPR3/ADCY6/DUOX1/ADCY7/ADCY3/CREB3L4	1.57382468410321
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	49/2273	168/9376	1.2031089602581	TNFSF10/BCL2/GLUL/IFNGR1/STAT1/STAT3/CAPN2/SMPD1/TRADD/IFNAR1/CFLAR/JAK1/CHMP1B/XIAP/CHMP4C/IFNGR2/VPS4B/EIF2AK2/TLR3/SLC25A4/STAT2/VPS4A/FAS/TNFRSF1A/GLUD1/CYLD/PYGL/SQSTM1/CHMP1A/TNFRSF10A/STAT6/SPATA2L/CAMK2D/CASP1/CYBB/MLKL/RIPK1/TNFRSF10B/IRF9/TRPM7/BIRC3/TLR4/TRAF5/RIPK3/MAPK10/BID/STAT5A/USP21/JAK2	1.50267657819674
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/2273	23/9376	1.61410891562578	ACAT1/PCYOX1/DHDDS/ZMPSTE24/HMGCR/ICMT/RCE1/MVD/MVK	1.66800866378776
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	31/2273	101/9376	1.26607222974827	VEGFA/BCL2/EDN1/STAT1/STAT3/CCND1/MAPK14/CDKN1B/SMAD3/DIAPH1/TGFBR2/SERPINE1/SMAD4/THBD/PLCB4/JUN/PIK3CA/NOS3/F3/PLCD3/TGFB2/CYBB/FN1/COL4A4/MAPK10/TGFBR1/STAT5A/VCAM1/NOX4/ICAM1/JAK2	1.52078466841127
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	28/2273	90/9376	1.28331622427531	IFNGR1/STAT1/STAT3/MAPK14/JAK1/NFATC3/IFNGR2/MAP2K1/PTPN11/MAP3K3/EGFR/CD4/MAP2K3/BATF3/JUN/PIK3CA/IKBKB/PPP3CC/NFKBIA/TLR4/TRAF6/TIRAP/CD3E/JAK2/BATF/CD247/TLR2/LAT	1.52771664045981
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	46/2273	157/9376	1.20858261339849	CDH1/YWHAH/CCND1/CTNNA1/SMAD3/MOB1A/FZD6/PARD6B/TGFBR2/WWC1/LLGL2/CSNK1D/FBXW11/SAV1/ITGB2/SERPINE1/SMAD4/NF2/PPP2R1B/SMAD1/STK3/LATS2/PARD3/RASSF6/PRKCI/CSNK1E/APC/WNT3/BMPR2/TGFB2/DLG1/FZD1/PPP2R2D/PARD6A/WTIP/BIRC3/SCRIB/BMPR1B/WNT4/TGFBR1/FZD5/BMPR1A/AMOT/LEF1/WNT6/FZD8	1.49090671917288
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	30/2273	98/9376	1.26273826732629	GSN/LIMK2/SCIN/FCGR3A/MAP2K1/ACTR3/SPHK1/BIN1/PIP5K1A/FCGR2A/VAV2/PTPRC/MYO10/PIK3CA/ACTR3C/VAV1/WAS/SYK/ASAP2/FCGR1A/NCF1/INPP5D/HCK/LIMK1/PLD2/MARCKS/SPHK2/PLA2G6/ACTR3B/LAT	1.47901859440446
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	41/2273	140/9376	1.20801960907548	SPP1/JAG1/CDH1/CALM2/CCND1/PRKAB1/GNAI2/RRAS2/PRKAG2/SMAD3/PRKAA2/MEF2A/SLC8A1/RRAS/MAP2K1/SPHK1/MYLK/SERPINE1/SMAD4/GNG11/PRKAA1/PLCB4/PPARGC1A/ITPR2/NOS3/PIK3C3/MEF2D/ITPR3/RYR3/ADCY6/MEF2C/MRAS/LIPE/GNG7/KLF2/PLAT/TGFBR1/ADCY7/ADCY3/SPHK2/GNG4	1.4027839244351
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	42/2273	144/9376	1.2031089602581	IGF1/STAT3/FGFR2/FGFR1/INHBB/MAPK14/IL6ST/JAK1/SMAD3/DLX5/FZD6/REST/ZFHX3/LIF/SKIL/IGF1R/MAP2K1/RIF1/ACVR1B/SMAD4/SMAD1/SMARCAD1/PIK3CA/APC/WNT3/BMPR2/PCGF2/ACVR1/LEFTY1/FZD1/LEFTY2/KLF4/BMPR1B/WNT4/FZD5/BMPR1A/SETDB1/POU5F1/ACVR2A/JAK2/WNT6/FZD8	1.38939867324156
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	24/2273	77/9376	1.28569714491404	CCND1/GADD45B/CDKN1B/RUNX1/SMAD3/MECOM/TGFBR2/RB1/MAP2K1/POLK/PTPN11/BCL2L1/SOS2/CDKN1A/SMAD4/PIK3CA/IKBKB/TGFB2/ARAF/CDKN2A/NFKBIA/SHC4/TGFBR1/STAT5A	1.42395933747561
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	32/2273	107/9376	1.23362841318855	CALM2/PRKAB1/PRKAG2/CREB3L1/FBP1/PRKAA2/SIK2/PHKB/G6PC3/CREB3L2/PFKP/PYGL/SIK1/CREBBP/LDHA/ATF2/PRKAA1/EP300/CPT1A/PLCB4/PPARGC1A/ITPR2/SIRT1/CAMK2D/ITPR3/PPP3CC/ACACA/PPARA/CPT1B/ACACB/PCK1/CREB3L4	1.3748824100741
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	11/2273	31/9376	1.46369016363198	ALDH3B1/CNDP2/ALDH6A1/HADHA/ALDH9A1/MLYCD/DPYD/ABAT/CSAD/ACOX3/CNDP1	1.46279519801205
NA	NA	hsa04517	IgSF CAM signaling	82/2273	299/9376	1.13125582120781	LMO7/MSN/CDH1/APP/TJP1/MBP/BAIAP2/FGFR1/MAPK14/ITGB3/IQGAP1/PARD6B/ACTN4/SRGAP1/RAP1A/CD2AP/PDPK1/MAP2K1/CABLES1/ESAM/CXADR/PTPN11/PVR/TJP2/ACTR3/MYLK/ITGB2/PAK2/MTSS1/VCL/PPFIA1/CD84/SPTAN1/MAGI1/VAV2/PARD3/DOK1/PIK3CA/PRKCI/ANK3/ACTR3C/BCAR1/VAV1/EPB41L1/LCP2/RAPGEF2/SRC/ITGAM/ERC1/ITGAX/SRGAP3/CADM1/DOK2/ICAM3/GIT1/JAM2/SLITRK4/PARD6A/LRRC4C/CD86/CASK/PLXNA3/TRAF6/NCAM1/INPP5D/EZR/ITGAL/MYH14/MAPK10/CD48/MPP3/RAPGEF6/CD96/UNC5B/ICAM2/MAGI2/ACTR3B/SPTBN2/ITGA4/ICAM1/TRPC6/CADM4	1.30481051740837
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	52/2273	184/9376	1.16574532795195	CXCR4/BOC/EFNA1/ARHGEF12/PLXNB2/GNAI2/MET/ROCK2/DPYSL2/PLXNB1/NFATC3/PARD6B/SEMA4D/SRGAP1/LIMK2/RRAS/PDPK1/ROCK1/ABLIM1/PTPN11/NTN4/SEMA4A/PAK2/PARD3/SSH2/PIK3CA/EPHB2/CAMK2D/NEO1/SRC/SEMA5A/BMPR2/SSH3/RYK/SRGAP3/PPP3CC/PARD6A/LRRC4C/SSH1/PLXNA3/EFNA5/EPHA2/BMPR1B/WNT4/LIMK1/ABLIM3/UNC5B/PLXNC1/LRIG2/SHH/TRPC6/EPHB6	1.28442765474194
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	66/2273	238/9376	1.1438923127544	VEGFA/IGF1/CALM2/NTRK2/EFNA1/FGFR2/FGFR1/MET/RRAS2/RASA2/NTF3/RAP1A/RAB5B/IGF1R/RRAS/MAP2K1/RALGAPA1/PTPN11/RAPGEF5/BCL2L1/STK4/SOS2/PDGFRA/PAK2/NF1/GNG11/RASAL1/EGFR/ABL2/RASAL2/REL/PIK3CA/RALGDS/RALGAPA2/RASGRP3/PDGFA/IKBKB/PDGFB/RASGRP2/RASA3/SHC4/RALGAPB/EXOC2/KSR1/ETS1/MRAS/FGF7/CSF1R/EFNA5/EPHA2/MAPK10/GNG7/INSR/TIAM1/FGF18/RASAL3/RASSF5/PLD2/PDGFD/RASA4/PLA2G6/KITLG/GNG4/CSF1/TGFA/LAT	1.27193507424794
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	7/2273	18/9376	1.60414528034414	ACSL5/ACSL1/ACSL3/MCAT/ACSF3/ACACA/ACACB	1.45127785331424
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/2273	32/9376	1.41794984601848	PCCA/ALDH6A1/HADHA/MLYCD/MCEE/LDHA/ABAT/ACSS2/ACACA/ACOX3/ACACB	1.33966802730734
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	11/2273	32/9376	1.41794984601848	BCL2/XIAP/BIRC6/TNFRSF1A/BCL2L1/BCL2L11/BOK/BIRC3/APAF1/MAPK10/BID	1.33966802730734
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/2273	15/9376	1.64997800263968	HEXA/GLB1/SLC33A1/B3GALT4/HEXB/ST3GAL5	1.42510746363445
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	44/2273	155/9376	1.17095213090558	RASD1/KMT2A/CCND1/GNAI2/CDKN1B/NCEH1/CREB3L1/FZD6/RB1/RAP1A/MAP2K1/CREB3L2/USP8/CDKN1A/ORAI1/ATF2/ATF6B/EGFR/PLCB4/AHR/ITPR2/APC/CAMK2D/WNT3/RBBP5/ITPR3/CDKN2A/GNA11/ADCY6/SP1/MEN1/CDKN2B/FZD1/SCARB1/WNT4/FZD5/KMT2D/ADCY7/PDE8B/ADCY3/LEF1/CREB3L4/WNT6/FZD8	1.21399194575078
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	12/2273	36/9376	1.3749816688664	GALNT15/GCNT1/GALNT3/GALNT11/B3GNT3/C1GALT1C1/GCNT3/GALNT7/GALNT9/ST6GALNAC2/GALNT10/GALNT6	1.27512364353967
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	8/2273	22/9376	1.49998000239971	AOC1/ALDH3B1/HAL/HNMT/CNDP2/ALDH9A1/CNDP1/MAOB	1.32809683168642
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	35/2273	122/9376	1.18338586254895	IGF1/STAT1/STAT3/GNAI2/MAPK14/CREB3L1/MAP2K1/CSH1/CREB3L2/MAP3K1/SOS2/JUNB/CREBBP/ATF2/ATF6B/IRS2/EP300/MAP2K3/PLCB4/MAP2K4/PIK3CA/ITPR2/BCAR1/ITPR3/GNA11/ADCY6/SHC4/IRS1/MAPK10/ADCY7/STAT5A/ADCY3/CREB3L4/MRAP2/JAK2	1.15330843614444
Human Diseases	Cancer: specific types	hsa05218	Melanoma	22/2273	73/9376	1.24313411157784	CDH1/IGF1/MITF/CCND1/GADD45B/FGFR1/MET/RB1/IGF1R/MAP2K1/POLK/CDKN1A/PDGFRA/EGFR/PIK3CA/PDGFA/ARAF/CDKN2A/PDGFB/FGF7/FGF18/PDGFD	1.17966926011545
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	42/2273	149/9376	1.16273617635682	AGPAT5/RRAS2/CYTH2/RAPGEF3/ARF1/RRAS/MAP2K1/PTPN11/FCER1G/AGPAT3/SPHK1/SOS2/PDGFRA/RHEB/PIP5K1A/EGFR/DGKH/PLCB4/PIK3CA/TSC2/RALGDS/PDGFA/AGPAT2/CYTH1/SYK/CYTH4/PDGFB/ADCY6/DGKE/LPAR1/SHC4/F2R/MRAS/LPAR6/INSR/ADCY7/PLD2/ADCY3/SPHK2/PDGFD/LPAR2/KITLG	1.13269094908921
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/2273	62/9376	1.26409605040943	SOD2/IGF1/CAT/PRKAB1/PRKAG2/PRKAA2/IGF1R/HSPA1B/HSPA1A/IRS2/PRKAA1/PIK3CA/SIRT1/CRYAB/ADCY6/IRS1/INSR/ADCY7/ADCY3	1.18019584955153
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/2273	44/9376	1.31248250209975	DYNC2LI1/AQP3/VAMP2/CREB3L1/DYNC1H1/RAB11B/RAB5B/CREB3L2/DYNC1LI1/DYNC1I1/DYNC2H1/ADCY6/ADCY3/CREB3L4	1.1752469298501
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	56/2273	205/9376	1.12681424570515	HLA-B/HLA-A/HLA-E/HLA-C/STAT3/YWHAH/CCND1/TRADD/SP100/GSN/IL6ST/JAK1/CDKN1B/HDAC7/CREB3L1/RASA2/LTBR/ACTN4/UBE3A/SCIN/RB1/EIF2AK2/CHD4/IRF7/MAPKAPK2/CREB3L2/CDKN1A/CREBBP/RBL2/ATF2/ATF6B/EP300/C3/REL/RBPJ/JUN/HLA-F/PIK3CA/SRC/GTF2E1/DLG1/UBR4/SYK/VAC14/CDKN2A/NFKBIA/IRF9/CDKN2B/EGR2/HDAC8/HDAC10/SCRIB/HDAC6/TRAF5/STAT5A/CREB3L4	1.03848702645906
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	8/2273	23/9376	1.43476348055625	POMGNT1/B4GALT2/POMT1/POMT2/B3GAT2/FKRP/POMGNT2/B3GALNT2	1.18088051453767
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	58/2273	214/9376	1.11797574945212	HLA-B/HLA-A/B2M/HLA-E/HLA-C/PDIA3/BCL2/CXCR4/CALM2/TRADD/TAPBP/GNAI2/MAPK14/ATM/TAPBPL/NFATC3/LIMK2/FBXW11/CUL5/MAP2K1/AP1G1/TAP1/FAS/TNFRSF1A/BCL2L1/SAMHD1/BST2/PAK2/APOBEC3G/GNG11/CALR/CD4/AP1S2/MAP2K3/JUN/HLA-F/PIK3CA/ITPR2/IKBKB/ITPR3/IRAK4/PPP3CC/RIPK1/GNA11/NFKBIA/AP1G2/TLR4/TRAF6/TRAF5/MAPK10/GNG7/LIMK1/BID/ATR/CD3E/GNG4/CD247/TLR2	0.98757238303167
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	12/2273	38/9376	1.30261421261028	NNMT/NT5E/NT5C2/SIRT7/NNT/NAMPT/SIRT1/SIRT5/NADSYN1/ENPP3/CD38/SARM1	1.05734966864413
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	31/2273	110/9376	1.16248450185978	VEGFA/BCL2/IFNGR1/EDN1/IGF1/STAT3/EPAS1/TIMP1/CDKN1B/LTBR/IFNGR2/IL6R/EGLN2/IGF1R/MAP2K1/ERBB2/PFKP/CDKN1A/CREBBP/LDHA/SERPINE1/EP300/EGFR/PIK3CA/NOS3/CAMK2D/CYBB/HKDC1/TLR4/INSR/PFKFB3	0.969675865916996
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	20/2273	68/9376	1.213219119588	STAT3/CCND1/RUNX1/JUP/MAP2K1/CD14/PER2/SOS2/PIK3CA/IKBKB/ITGAM/PML/SPI1/ARAF/CSF1R/FCGR1A/STAT5A/LEF1/ZBTB16/RARA	0.998198386487958
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/2273	42/9376	1.2767686925188	CP/ACSL5/ACSL1/ACSL3/LPCAT3/SLC39A8/SLC11A2/PRNP/CYBB/ATG7/SLC39A14/SAT1/STEAP3	1.01688574135281
NA	NA	hsa04981	Folate transport and metabolism	10/2273	31/9376	1.33062742148362	ABCC3/FOLR1/ABCC5/MTR/FOLR2/ABCC4/SLCO2B1/FPGS/BHMT2/MTHFR	1.04302450733287
Human Diseases	Cancer: specific types	hsa05214	Glioma	22/2273	76/9376	1.19406302822609	IGF1/CALM2/CCND1/GADD45B/RB1/IGF1R/MAP2K1/POLK/SOS2/CDKN1A/PDGFRA/EGFR/PIK3CA/PDGFA/CAMK1/CAMK2D/ARAF/CDKN2A/PDGFB/SHC4/CAMK1D/TGFA	0.960887568146481
Organismal Systems	Immune system	hsa04611	Platelet activation	35/2273	126/9376	1.14581805738867	ARHGEF12/GNAI2/MAPK14/ITGB3/ROCK2/RAP1A/TLN1/PPP1R12A/ROCK1/FCER1G/MYLK/SNAP23/ORAI1/STIM1/ITGA2/FCGR2A/PLCB4/TBXAS1/PIK3CA/PRKCI/ITPR2/NOS3/LCP2/SRC/FERMT3/ITPR3/SYK/ADCY6/RASGRP2/F2R/ARHGEF1/APBB1IP/ADCY7/ADCY3/PTGS1	0.932159356442765
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	36/2273	130/9376	1.14229246336593	EDNRB/RXFP1/VEGFA/EDN1/GNAI2/MAPK14/CREB3L1/TGFBR2/MAP2K1/CREB3L2/SOS2/GNG11/ATF2/ATF6B/EGFR/PLCB4/MAP2K4/JUN/PIK3CA/GNA15/NOS3/SRC/ARRB2/ADCY6/NFKBIA/SHC4/MMP9/COL4A4/MAPK10/GNG7/TGFBR1/ADCY7/ADCY3/CREB3L4/ARRB1/GNG4	0.924147043067379
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	15/2273	50/9376	1.23748350197976	AOC1/PYCR2/GOT1/CNDP2/ALDH9A1/LAP3/GOT2/ALDH18A1/NOS3/CKMT2/SAT1/CNDP1/MAOB/P4HA3/HOGA1	0.952434656540215
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	15/2273	50/9376	1.23748350197976	CD81/SDC2/COMP/SDC1/MET/ITGB2/IL18/TGFB2/TLR4/CD40/ITGAL/IL10/VCAM1/ICAM1/TLR2	0.952434656540215
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	21/2273	73/9376	1.18662801559703	STAT3/CCND1/GADD45B/MET/RB1/PDPK1/MAP2K1/ERBB2/POLK/STK4/SOS2/CDKN1A/EGFR/RXRB/PIK3CA/ARAF/CDKN2A/FHIT/RASSF5/STAT5A/TGFA	0.905505737748681
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	28/2273	100/9376	1.15498460184778	TNFSF10/CXCL14/IL20RA/CXCR4/IL6ST/LTBR/TNFRSF14/IL6R/TNFRSF1A/TNFRSF10A/CCL28/IL18/TNFRSF10B/CXCL10/CCL4/CSF1R/CCL18/CCL3/XCL2/IL10/CX3CL1/CX3CR1/CCL7/XCL1/CCL3L3/IL2RA/CSF1/TNFRSF10D	0.881399156775576
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	20/2273	70/9376	1.1785557161712	VEGFA/EPAS1/MET/RAP1A/EGLN2/MAP2K1/PTPN11/SOS2/CDKN1A/PAK2/CREBBP/EP300/JUN/PIK3CA/TGFB2/ARAF/PDGFB/ETS1/ARNT2/TGFA	0.848214520084356
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	32/2273	117/9376	1.128190087275	MEAF6/SMARCC2/EPC1/BRD7/INO80D/BAZ2B/RBBP4/SMARCC1/SRCAP/SMARCA5/BPTF/CHD4/INO80/RSF1/MBD2/BCL7A/BAZ2A/PBRM1/SMARCD1/BAZ1B/BRD8/EPC2/SMARCA1/DPF2/ING3/GATAD2B/EP400/CECR2/MTA1/NFRKB/SMARCD3/TRRAP	0.789277605868946
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	17/2273	59/9376	1.18854347647774	CDA/NT5E/NME3/DCTD/NT5C2/ENTPD6/ENTPD4/TYMP/NME7/CANT1/DPYD/RRM2B/ENTPD1/AK9/CDADC1/ENPP3/CMPK2	0.821795800089219
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	27/2273	98/9376	1.13646444059366	NPR1/ATP1B1/ATP1A1/CALM2/CREB3L1/CREB3L2/ATP2B4/ORAI1/ATF2/ATF6B/DAGLB/PLCB4/ITPR2/NR4A2/CAMK1/CAMK2D/ITPR3/PRKD1/GNA11/ADCY6/CAMK1D/SCARB1/LIPE/PRKD2/ADCY7/ADCY3/CREB3L4	0.768192038285663
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	14/2273	48/9376	1.2031089602581	ACAT1/IVD/ACAA2/PCCA/ALDH6A1/HADHA/ALDH9A1/MCCC1/MCEE/AUH/MCCC2/ACSF3/OXCT1/ABAT	0.798031219678277
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	22/2273	79/9376	1.14871886259725	SLC1A1/SLC18A2/ATP6V1D/ATP6V0A2/SLC6A12/ATP6V0B/ATP6V0A1/VAMP2/NAPA/AP2B1/STX3/STX2/ATP6V1C1/AP2A2/CLTC/ATP6V1H/ATP6V0E2/TCIRG1/STXBP1/SLC6A13/ATP6V1E2/UNC13B	0.750883626190432
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	37/2273	138/9376	1.10596351626211	CALM2/FLOT1/PRKAB1/PRKAG2/FBP1/PRKAA2/RHOQ/PHKB/PRKAR1A/PDPK1/MAP2K1/PRKAR2A/G6PC3/PTPN1/PYGL/SOS2/EXOC7/RHEB/IRS2/PRKAA1/PPARGC1A/PIK3CA/PRKCI/TSC2/IKBKB/ARAF/SHC4/HKDC1/ACACA/IRS1/LIPE/MAPK10/INSR/ACACB/SREBF1/PPP1R3D/PCK1	0.709367642343971
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	24/2273	87/9376	1.13791586388944	BCL2/CCND1/GADD45B/SMAD3/TGFBR2/APPL1/MAP2K1/POLK/SOS2/CDKN1A/SMAD4/BCL2L11/EGFR/JUN/PIK3CA/RALGDS/APC/TGFB2/MSH3/ARAF/MAPK10/TGFBR1/LEF1/TGFA	0.731061339318033
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	25/2273	91/9376	1.13322665016462	CD81/NFATC3/IFITM1/MAP2K1/SOS2/VAV2/JUN/PIK3CA/RASGRP3/VAV1/IKBKB/LILRB4/SYK/PPP3CC/MALT1/NFKBIA/LILRB1/CD72/INPP5D/PIK3AP1/LILRB5/DAPP1/LILRB2/CD22/BANK1	0.722412578186895
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	42/2273	158/9376	1.09650436884283	ATP6V1D/IGF1/RPS6KA2/LPIN3/SGK1/RPS6KA1/FZD6/PRKAA2/CLIP1/IGF1R/PDPK1/MAP2K1/ATP6V1C1/TNFRSF1A/ATP6V1H/SOS2/LPIN2/RHEB/PRKAA1/RRAGB/PIK3CA/TSC2/FNIP1/RICTOR/IKBKB/WNT3/ULK2/LPIN1/MIOS/RPS6KA3/FZD1/SESN2/IRS1/PRR5L/WNT4/INSR/FZD5/RRAGD/RNF152/ATP6V1E2/WNT6/FZD8	0.692024730726217
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	27/2273	99/9376	1.12498500179978	SLC44A1/SLC44A4/SLC44A3/GPCPD1/PDPK1/MAP2K1/SOS2/PDGFRA/CHKA/RHEB/PIP5K1A/EGFR/DGKH/CHKB/JUN/PIK3CA/TSC2/RALGDS/PDGFA/SLC22A5/WAS/PDGFB/DGKE/SP1/MAPK10/PLD2/PDGFD	0.70719009379963
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/2273	30/9376	1.23748350197976	ABCC3/FOLR1/ABCC5/MTR/FOLR2/ABCC4/FPGS/IKBKB/MTHFR	0.73696291182959
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	18/2273	65/9376	1.14229246336593	AGPAT5/PNPLA2/LPIN3/MGLL/ALDH9A1/AGPAT3/LPIN2/DGKH/LCLAT1/LIPC/MBOAT1/AGPAT2/LPIN1/DGKE/DGAT1/MOGAT1/LPL/GK	0.651185710133459
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	11/2273	38/9376	1.19406302822609	UXS1/GALE/HEXA/GFPT1/PMM2/HEXB/CHIA/HKDC1/GNPDA2/AMDHD2/RENBP	0.678066230997512
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	12/2273	42/9376	1.1785557161712	AOC1/ACAT1/CAT/ALDH8A1/IDO1/HADHA/DHTKD1/ALDH9A1/DLST/KYNU/MAOB/IDO2	0.656037936079781
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	24/2273	89/9376	1.11234472088069	SPP1/LAMB3/TNC/LAMC1/COMP/ITGA3/SDC1/ITGB3/CD44/AGRN/SDC4/LAMA5/CD47/ITGB5/ITGAV/ITGA2/LAMB2/FREM2/LAMC2/FN1/COL4A4/ITGB6/ITGB7/ITGA4	0.602385346623842
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	7/2273	23/9376	1.25541804548672	GLUL/GOT1/ASL/GLUD1/GOT2/NOS3/GLS	0.693752365287586
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	50/2273	193/9376	1.06863860274591	CXCL14/STAT1/CXCR4/STAT3/GNAI2/ROCK2/RAP1A/MAP2K1/CXCL16/STAT2/ROCK1/SOS2/GNG11/CCL28/VAV2/PARD3/PLCB4/PIK3CA/BCAR1/VAV1/IKBKB/SRC/DOCK2/ARRB2/WAS/ADCY6/RASGRP2/NFKBIA/CXCL10/CCL4/SHC4/CCL18/GRK4/FGR/NCF1/CCL3/HCK/XCL2/CX3CL1/GNG7/CX3CR1/TIAM1/ADCY7/CCL7/ADCY3/XCL1/CCL3L3/ARRB1/GNG4/JAK2	0.545028541054277
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/2273	12/9376	1.3749816688664	VKORC1/VKORC1L1/COQ2/COQ7	0.735248939589274
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	10/2273	35/9376	1.1785557161712	ENOSF1/SORD/FBP1/PFKP/PMM2/PFKFB2/HKDC1/GMDS/PFKFB3/HSD17B14	0.598653523317393
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	43/2273	166/9376	1.06850985110702	EDNRB/NPR1/ATP1B1/ATP1A1/CALM2/BDKRB2/GNAI2/ROCK2/CREB3L1/NFATC3/ATP2A2/MEF2A/SLC8A1/MAP2K1/SLC25A4/PPP1R12A/CREB3L2/ROCK1/GTF2I/MYLK/ATP2B4/ATF2/ATF6B/IRS2/PLCB4/KCNMB2/ITPR2/NOS3/MEF2D/ITPR3/PPP3CC/GNA11/RGS2/ADCY6/MEF2C/IRS1/INSR/ADCY7/ADCY3/CREB3L4/CNGA1/KCNMA1/TRPC6	0.503780903919338
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	32/2273	122/9376	1.08195278861619	ATP1B1/STAT1/ATP1A1/CCND1/NCOR1/ITGB3/NCOA3/ATP2A2/PDPK1/MAP2K1/PFKP/NOTCH2/RHEB/CREBBP/ITGAV/THRA/NCOA1/EP300/RXRB/PLCB4/PIK3CA/TSC2/PLCD3/SRC/MED17/MED14/RCAN1/PFKFB2/MED1/SIN3A/WNT4/NOTCH1	0.51539873991856
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	40/2273	154/9376	1.07141428742837	NPR1/CALM2/CCND1/PRKAB1/GNAI2/PRKAG2/ROCK2/NFATC3/PRKAA2/MAP2K1/PPP1R12A/ROCK1/MYLK/CDKN1A/PRKAA1/EGFR/PLCB4/JUN/PPP1R12C/ITPR2/NOS3/CAMK1/CAMK2D/SRC/ITPR3/CAMKK2/RCAN1/PPP3CC/RYR3/RGS2/ADCY6/MAP2K5/MEF2C/CAMK1D/PPP1R12B/MAPK7/ADCY7/ADCY3/CD38/CACNA2D4	0.50547229560626
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/2273	43/9376	1.1511474437021	ACSL5/ACSL1/ACAT1/ACAA2/ACSL3/HADHA/ALDH9A1/CPT2/CPT1A/ACOX3/CPT1B/CYP2U1	0.56193858056371
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/2273	16/9376	1.28904531456225	HEXA/A4GALT/NAGA/HEXB/GBGT1	0.654564502513702
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	16/2273	59/9376	1.11862915433199	GSTT1/GPX3/TXNDC12/GSTM3/MGST1/GGT1/GSTK1/GPX1/MGST2/LAP3/GPX7/GSTM4/RRM2B/ANPEP/LANCL1/GGT7	0.517063451992066
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	36/2273	139/9376	1.06833108084584	HSP90B1/CTSD/FKBP5/BCL2/CALM2/GNAI2/EBAG9/CREB3L1/NCOA3/MAP2K1/HSPA1B/CREB3L2/SOS2/ATF2/HSPA1A/ATF6B/NCOA1/EGFR/PLCB4/JUN/PIK3CA/ITPR2/NOS3/SRC/ITPR3/ADCY6/SP1/SHC4/HBEGF/MMP9/ADCY7/ADCY3/PGR/CREB3L4/TGFA/RARA	0.459118367377218
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	8/2273	28/9376	1.1785557161712	ATP6V1D/ATP6V0A2/ATP6V0A1/ATP6V1C1/ATP6V0E2/TCIRG1/SLC12A7/ATP6V1E2	0.535251472241179
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	33/2273	128/9376	1.06346238451386	NPR1/NT5E/GDA/NME3/ADK/PDE7B/GMPR/PAPSS1/NUDT9/ENPP4/NT5C2/ENTPD6/PDE6D/ENTPD4/NME7/CANT1/PDE9A/PRPS1/ADCY6/FHIT/RRM2B/PDE4B/ENTPD1/AK9/LACC1/PDE7A/AMPD3/ADCY7/ENPP3/AMPD2/PDE8B/ADCY3/PDE6B	0.408942181231784
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/2273	13/9376	1.26921384818437	RAD50/POLM/DCLRE1C/POLL	0.549447256413444
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	5/2273	17/9376	1.213219119588	GGT1/CSAD/ADO/FMO5/GGT7	0.497737464941706
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	5/2273	17/9376	1.213219119588	GLUL/GLUD1/CA5B/CA8/CA13	0.497737464941706
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/2273	17/9376	1.213219119588	LAMP1/LAMP2/PCDH1/PCDH7/MYH14	0.497737464941706
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	26/2273	101/9376	1.06186703140178	EDNRB/EDN1/MITF/CALM2/GNAI2/CREB3L1/FZD6/MAP2K1/CREB3L2/CREBBP/EP300/PLCB4/CAMK2D/WNT3/ADCY6/FZD1/WNT4/FZD5/ADCY7/MC1R/ADCY3/LEF1/CREB3L4/KITLG/WNT6/FZD8	0.353612374072086
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	24/2273	93/9376	1.06450193718689	CALM2/MAPK14/MAP2K1/MAP3K1/MAP3K3/SOS2/MAP3K4/EGFR/MAP2K3/PLCB4/MAP2K4/JUN/ITPR2/CAMK2D/SRC/ITPR3/GNA11/ADCY6/HBEGF/MAPK10/MAPK7/ADCY7/PLD2/ADCY3	0.353618115821976
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	23/2273	89/9376	1.06599702417732	GJA1/TJP1/GNAI2/CSNK1D/MAP2K1/SOS2/PDGFRA/EGFR/PLCB4/ITPR2/PDGFA/SRC/ITPR3/PDGFB/GNA11/ADCY6/LPAR1/MAP2K5/HTR2B/MAPK7/ADCY7/ADCY3/PDGFD	0.353871904024945
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	43/2273	170/9376	1.04336844284568	GSTT1/GSTM3/MGST1/CCND1/GADD45B/NFE2L2/MET/SMAD3/SMARCC2/FZD6/BRD7/TGFBR2/MGST2/RB1/SMARCC1/IGF1R/MAP2K1/POLK/BCL2L1/SOS2/CDKN1A/SMAD4/PBRM1/SMARCD1/EGFR/KEAP1/PIK3CA/APC/WNT3/TGFB2/ARAF/CDKN2A/GSTM4/SHC4/FZD1/WNT4/TGFBR1/FZD5/SMARCD3/LEF1/TGFA/WNT6/FZD8	0.322795337523378
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	17/2273	65/9376	1.07883177095672	NCEH1/CREB3L1/CREB3L2/ORAI1/ATF2/ATF6B/PLCB4/ITPR2/ITPR3/GNA11/ADCY6/SP1/SCARB1/ADCY7/PDE8B/ADCY3/CREB3L4	0.360764874942891
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/2273	37/9376	1.11485000178357	RIMKLB/GLUL/GOT1/GFPT1/ASL/GLUD1/GOT2/ABAT/GLS/ALDH5A1	0.39595527156379
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	10/2273	37/9376	1.11485000178357	APOL1/F2RL1/IDO1/FAS/PLCB4/IL18/IL10/IDO2/VCAM1/ICAM1	0.39595527156379
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/2273	37/9376	1.11485000178357	PAX8/CDH1/CCND1/GADD45B/MAP2K1/POLK/TPR/CDKN1A/RXRB/LEF1	0.39595527156379
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	38/2273	150/9376	1.04498606833847	BCL2/CDH1/CCND1/GADD45B/FGFR2/CTNNA1/MET/CDKN1B/SMAD3/FZD6/TGFBR2/JUP/RB1/MAP2K1/ERBB2/POLK/SOS2/CDKN1A/SMAD4/EGFR/RXRB/PIK3CA/APC/WNT3/TGFB2/ARAF/CDKN2B/SHC4/FZD1/FGF7/WNT4/TGFBR1/FZD5/FGF18/LEF1/SHH/WNT6/FZD8	0.31418206640707
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	63/2273	253/9376	1.02716021903459	BCL2/CAPN2/CALCOCO2/TRADD/CTTN/CAST/MAPK14/CYTH2/ROCK2/ATM/CAPNS1/WIPI1/DIAPH1/ARF1/IL1R1/WIPI2/ACTN4/CD44/FNBP1L/FBXW11/TLN1/UBE2D1/CD14/ROCK1/TNFRSF1A/BCL2L1/ACTR3/SQSTM1/U2AF1L4/VCL/C3/RRAGB/EGFR/PLCB4/JUN/IL18/PIK3CA/ITPR2/ACTR3C/BCAR1/PIK3C3/IKBKB/PLCD3/SRC/ITPR3/ATG14/CASP1/CYTH1/CYTH4/RIPK1/MALT1/TLR5/NFKBIA/HKDC1/NAIP/TLR4/TRAF6/TECPR1/TRAF5/MAPK10/RRAGD/ELMO2/ACTR3B	0.247736010717372
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	74/2273	298/9376	1.02431520298101	TNFSF10/TNFRSF12A/TNFRSF11B/CXCL14/IFNGR1/IL20RA/CXCR4/IL1R2/IFNAR1/IL13RA1/INHBB/CSF2RA/IL6ST/CXCL17/LTBR/IL1R1/IFNGR2/TGFBR2/TNFRSF14/IL6R/LIF/CSH1/CXCL16/GDF15/ACVR1B/FAS/TNFRSF1A/LEPR/OSMR/TNFRSF10A/CCL28/TNFSF13B/CLCF1/CD4/IL4R/IL18/IL17RC/BMPR2/TGFB2/IL15RA/ACVR1/TNFRSF10B/IL15/CXCL10/CCL4/CSF1R/CD40/CCL18/EDA/CCL3/BMPR1B/OSM/TNFRSF18/XCL2/IL10/CX3CL1/TNFRSF25/CX3CR1/TGFBR1/PRL/PRLR/CTF1/BMPR1A/IL17RA/CCL7/XCL1/CCL3L3/IL2RA/ACVR2A/CSF1/TNFRSF21/RELT/TNFRSF10D/IL17RB	0.241298927123721
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	10/2273	38/9376	1.0855118438419	ATP1B1/IGF1/ATP1A1/SGK1/SCNN1A/PDPK1/NEDD4L/PIK3CA/IRS1/INSR	0.298782793350891
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	25/2273	99/9376	1.04165277944424	IGF1/CALM2/F2RL1/BDKRB2/MAPK14/IL1R1/HRH1/PTGER2/CYP2J2/PTGER4/MAP2K3/PLCB4/ALOX12/PIK3CA/ITPR2/CAMK2D/SRC/ITPR3/ADCY6/TRPV2/HTR2B/MAPK10/ADCY7/ADCY3/PLA2G6	0.235679742193207
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/2273	14/9376	1.1785557161712	B3GNT2/B4GALT2/B3GNT7/CHST2	0.378196849012749
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	18/2273	71/9376	1.04576070589839	STAT1/STAT3/CCND1/MAPK14/MAP2K1/IRF1/SOS2/CISH/PIK3CA/SRC/SHC4/MAPK10/PRL/PRLR/SOCS5/ELF5/STAT5A/JAK2	0.21894153044116
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/2273	59/9376	1.04871483218624	CDH1/CCND1/GADD45B/CTNNA1/PDPK1/MAP2K1/ERBB2/POLK/SOS2/CDKN1A/EGFR/PIK3CA/APC/ARAF/LEF1	0.212331103894913
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	19/2273	76/9376	1.0312362516498	ACSL5/ACSL1/CYP27A1/ACSL3/SLC27A4/PDPK1/PLTP/CPT2/RXRB/CPT1A/ME3/LPL/ACOX3/PPARA/CPT1B/GK/NR1H3/PCK1/SLC27A1	0.15466380258079
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/2273	72/9376	1.0312362516498	TRADD/MAPK14/AZI2/ZNFX1/IRF7/ADAR/CYLD/MAP3K1/DHX58/TRIM25/IKBKB/RIPK1/NFKBIA/CXCL10/TRAF6/MAPK10/MAVS/NLRX1	0.15050632764025
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/2273	31/9376	1.06450193718689	RBKS/FBP1/DERA/PFKP/H6PD/IDNK/RPE/PRPS1	0.203483125974498
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/2273	31/9376	1.06450193718689	GLUL/ACAT1/CAT/ACO2/PCCA/MCEE/ACSS2/HOGA1	0.203483125974498
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	7/2273	27/9376	1.06943018689609	ACAT1/ACSM3/HADHA/OXCT1/ABAT/ACSM5/ALDH5A1	0.204367619023239
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/2273	23/9376	1.07607261041718	CTSA/ATP6AP2/PRCP/NLN/LNPEP/ANPEP	0.2066242160375
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	62/2273	254/9376	1.00687634019351	EDNRB/VEGFA/TPCN1/CXCR4/CALM2/ERBB3/NTRK2/FGFR2/FGFR1/BDKRB2/MET/ASPH/NFATC3/ORAI2/ATP2A2/HRH1/PHKB/SLC8A1/ERBB2/SLC25A4/STIM2/SPHK1/MYLK/ATP2B4/MST1/PDGFRA/ORAI1/STIM1/EGFR/MCOLN1/PLCB4/ORAI3/ITPR2/GNA15/NOS3/PDGFA/CAMK1/CAMK2D/PLCD3/ITPR3/PPP3CC/TNNC2/PDGFB/RYR3/GNA11/F2R/CAMK1D/FGF7/ITPKC/PTGER3/HTR2B/CYSLTR1/FGF18/ADCY7/P2RX7/PTAFR/ADCY3/SPHK2/CD38/PDGFD/TGFA/TPCN2	0.0628483134099568
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	53/2273	217/9376	1.00747504769474	HSP90B1/JAG1/GSTT1/VEGFA/BCL2/GSTM3/MGST1/STAT3/CCND1/RPS6KA2/RPS6KA1/GNAI2/EPHX1/CREB3L1/XIAP/MGST2/RB1/KPNA4/MAP2K1/CREB3L2/NOTCH2/KLF5/SOS2/ATF2/ATF6B/KPNA3/EGFR/RXRB/JUN/AHR/PIK3CA/KPNA1/BCL6/SRC/ARRB2/ADCY6/GSTM4/RPS6KA3/KPNA5/FGF7/KLF4/MIR29A/EPHX4/PPARA/FGF18/ADCY7/PAQR7/STAT5A/ADCY3/PGR/CREB3L4/ARRB1/JAK2	0.0630208496671781
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/2273	85/9376	1.01910406045392	CDA/NT5E/GDA/NME3/ADK/GMPR/DCTD/NT5C2/ENTPD6/ENTPD4/TYMP/NME7/CANT1/RRM2B/ENTPD1/AK9/LACC1/AMPD3/ENPP3/AMPD2/CMPK2	0.10008485522693
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	17/2273	69/9376	1.01629079872734	MAPK14/PDPK1/MAP2K1/ALOX5/FCER1G/SOS2/VAV2/MAP2K3/MAP2K4/PIK3CA/VAV1/LCP2/ALOX5AP/SYK/INPP5D/MAPK10/LAT	0.0768292361094638
Organismal Systems	Digestive system	hsa04978	Mineral absorption	15/2273	61/9376	1.01433073932767	SLC34A2/CYBRD1/ATP1B1/ATP1A1/MT1M/SLC31A1/SLC8A1/SLC11A2/SLC30A1/ATP2B4/SLC26A6/TRPM7/STEAP2/SLC5A1/ATP7A	0.063519421334464
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	21/2273	86/9376	1.00725401323934	ERBB3/CDKN1B/MAP2K1/ERBB2/SOS2/CDKN1A/PAK2/EGFR/ABL2/MAP2K4/JUN/PIK3CA/CAMK2D/SRC/ARAF/SHC4/HBEGF/BTC/MAPK10/STAT5A/TGFA	0.0382282274432741
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	21/2273	86/9376	1.00725401323934	GJA1/ITGA3/CTNNA1/ITGB3/SGCB/JUP/ATP2A2/SLC8A1/ITGB5/SGCE/ITGAV/ITGA2/SNTB2/SSPN/SNTB1/ITGB6/ACTN2/ITGB7/LEF1/CACNA2D4/ITGA4	0.0382282274432741
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/2273	32/9376	1.0312362516498	GALE/GLB1/G6PC3/GAA/PFKP/B4GALT2/GANC/HKDC1	0.100122557830338
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	19/2273	78/9376	1.00479429647929	CDH1/CTTN/CTNNA1/MET/CD2AP/CAV2/CLTC/ACTR3/VCL/PIK3CA/ACTR3C/BCAR1/RHOG/SRC/MAD2L2/SHC4/FN1/ELMO2/ACTR3B	0.0240514833640964
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/2273	28/9376	1.0312362516498	ELOVL1/ACAA2/ELOVL7/HSD17B12/HADHA/PPT1/TECR	0.0936360372065702
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/2273	28/9376	1.0312362516498	B3GNT2/B3GNT3/B4GALNT2/A4GALT/GCNT2/B4GALT2/ST3GAL6	0.0936360372065702
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/2273	83/9376	0.99396265219258	IFI16/DNASE2/IRF7/ADAR/SAMHD1/IL18/POLR3E/IKBKB/CASP1/MLKL/RIPK1/NFKBIA/CXCL10/CCL4/ZDHHC1/POLR3F/RIPK3/MAVS/POLR3A/POLR3B	-0.0312515615253897
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	13/2273	54/9376	0.993042316403513	HES1/POLK/WDR48/PMS2/POLI/REV1/REV3L/TOP3A/FAN1/ATR/POLH/PALB2/TOP3B	-0.029004905475711
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/2273	33/9376	0.999986668266475	STX7/VAMP2/STX3/STX2/SNAP23/VAMP5/STX16/STX11	-4.33975156692567e-05
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/2273	16/9376	1.0312362516498	ALDH3B1/GOT1/GOT2/MAOB	0.0707368031635811
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	29/2273	122/9376	0.980519714683418	PPP2R5A/MAPK14/NFATC3/PPP2R3A/PDPK1/MAP2K1/PTPN11/SOS2/PAK2/PPP2R1B/VAV2/CD4/PTPRC/JUN/PIK3CA/VAV1/LCP2/IKBKB/DLG1/PPP3CC/MALT1/NFKBIA/PPP2R2D/MAPK10/IL10/TEC1/CD3E/CD247/LAT	-0.122510956307316
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/2273	12/9376	1.0312362516498	CD46/NPC1/NCAM1	0.0612467830005926
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/2273	59/9376	0.97880051004049	NPR1/PNPLA2/GNAI2/MGLL/IRS2/PIK3CA/ADCY6/IRS1/LIPE/PTGER3/INSR/ADCY7/ADCY3/PTGS1	-0.0924012442022405
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	9/2273	38/9376	0.976960659457707	TAP1/ORAI1/CD4/PTPRC/DCLRE1C/RFX5/CD40/CIITA/CD3E	-0.0805006442957313
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	35/2273	148/9376	0.975493751560623	JAG1/IGF1/CCND1/GADD45B/FGFR1/FZD6/NCOA3/RB1/HES1/IGF1R/MAP2K1/ERBB2/POLK/NOTCH2/SOS2/CDKN1A/NCOA1/EGFR/JUN/PIK3CA/APC/WNT3/ARAF/SP1/SHC4/FZD1/FGF7/WNT4/FZD5/FGF18/NOTCH1/PGR/LEF1/WNT6/FZD8	-0.169988031810578
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/2273	21/9376	0.982129763476002	COASY/VNN1/DPYD/CSAD/ENPP3	-0.0463748481835492
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	34/2273	144/9376	0.973945348780369	MAP3K5/ERN1/ATXN2/WIPI1/XBP1/WIPI2/OMA1/ATP2A2/SLC25A4/NRBF2/RB1CC1/AFG3L2/ATXN2L/PLCB4/RBPJ/PIK3CA/ITPR2/ATXN1L/PIK3C3/OPA1/ITPR3/ATG14/ULK2/ATXN1/SP1/RORA/ATG2A/KCNC3/ATG2B/CIC/MAPK10/PSMA6/VLDLR/SPTBN2	-0.178230924870698
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	42/2273	178/9376	0.9733016307706	CCND1/GPC4/ROCK2/SMAD3/TLE2/FZD6/NFATC3/FBXW11/PSEN1/CREBBP/SMAD4/CHD8/TBL1XR1/EP300/PLCB4/JUN/CSNK1E/CELSR2/APC/LZTS2/SIRT1/CAMK2D/WNT3/RYK/PPP3CC/FZD1/TLE6/WNT4/ZNRF3/CELSR1/MAPK10/PRICKLE2/VANGL1/MMP7/FZD5/CCDC88C/MCC/LEF1/RNF43/WNT6/DKK1/FZD8	-0.203428821038942
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/2273	94/9376	0.965412661118964	LCN2/HSP90B1/TRADD/MAPK14/USP25/S100A9/JUND/JUN/IL17RC/FOSB/IKBKB/NFKBIA/CXCL10/TRAF6/MMP9/TRAF5/MUC5B/MAPK10/MAPK7/IL17RA/CCL7/IL17RB	-0.190644702783151
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/2273	17/9376	0.970575295670402	PAPSS1/MTR/PSTK/CTH	-0.0686888575845031
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	24/2273	103/9376	0.961152234547388	LAMB3/LAMC1/IL1R2/IL1R1/ACTN4/LAMA5/RAB5B/CD14/ITGB2/VCL/PLCB4/PIK3CA/LAMB2/GNA15/ITGAM/TGFB2/LAMC2/GNA11/FN1/TLR4/C8B/COL4A4/IL10/TLR2	-0.224253367918231
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	23/2273	99/9376	0.958320557088705	EDN1/IGF1/ITGA3/PRKAB1/PRKAG2/ITGB3/PRKAA2/SGCB/ATP2A2/SLC8A1/ITGB5/SGCE/ITGAV/ITGA2/PRKAA1/SNTB2/SSPN/SNTB1/TGFB2/ITGB6/ITGB7/CACNA2D4/ITGA4	-0.235830609413217
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/2273	78/9376	0.951910386138279	TOB1/DDX6/BTG2/CNOT2/PFKP/CNOT6L/CNOT4/TOB2/PARN/XRN1/ZCCHC7/DIS3/PNPT1/DCP1B/CNOT10/PAN2/DCP1A/PATL1	-0.241250526073283
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/2273	44/9376	0.93748750149982	PARP4/MBD4/RFC1/MPG/PNKP/PARP3/POLL/NEIL1/OGG1/POLG	-0.235109554762025
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/2273	27/9376	0.916654445910935	ELOVL1/HSD17B4/ELOVL7/HSD17B12/TECR/ACOX3	-0.24532747507718
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/2273	36/9376	0.916654445910935	G6PC3/GAA/PYGL/GYG1/GANC/HKDC1/ENPP3/PGM2L1	-0.283416218515856
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	15/2273	67/9376	0.923495150731166	CALM2/RPS6KA2/RPS6KA1/RAPGEF3/RAP1A/MAP2K1/CREBBP/EP300/PLCB4/ITPR2/CAMK2D/ITPR3/ARAF/PPP3CC/RPS6KA3	-0.355499749265648
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2273	23/9376	0.896727175347654	ATP1B1/ATP1A1/GLUD1/GLS/PCK1	-0.280503933212587
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	14/2273	63/9376	0.916654445910935	GADD45B/FZD6/POLK/CDKN1A/APC/WNT3/FZD1/WNT4/SUFU/FZD5/LEF1/SHH/WNT6/FZD8	-0.375467507922052
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/2273	116/9376	0.924556639410167	ACAT1/CAT/ACO2/GOT1/PCCA/FBP1/SDHC/ALDH6A1/SDHD/PFKP/ME2/GLUD1/MCEE/H6PD/DLST/GOT2/ADPGK/IDNK/PC/RPE/SDS/PRPS1/HKDC1/ACSS2/ME3/ACOX3	-0.462497059196218
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	19/2273	86/9376	0.9113250595975	ATP1B1/ATP1A1/VAMP2/CREB3L1/RIMS2/CREB3L2/ATF2/ATF6B/PLCB4/KCNMB2/CAMK2D/ITPR3/GNA11/ADCY6/PCLO/ADCY7/ADCY3/CREB3L4/KCNMA1	-0.467311773273422
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/2273	51/9376	0.889694021031202	PLD3/UGT8/PAFAH1B2/LPCAT1/PAFAH1B1/CEPT1/PAFAH2/PLA2G7/TMEM86A/PLD2/PLA2G6	-0.446811322490741
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/2273	24/9376	0.859363543041502	B3GAT3/B3GALT6/EXT2/EXT1/GLCE	-0.390225582194726
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	53/2273	233/9376	0.938292211801536	VCAN/SYNE2/SYNE1/ATP1B1/TMOD1/LBR/SDC2/ATP1A1/COMP/ITGA3/SDC1/ITGB3/DIAPH1/SGCB/JUP/TMEM43/AGRN/SDC4/TLN1/ITGB5/SGCE/ITGAV/VCL/ITGA2/FHL1/SPTAN1/SNTB2/SUN2/ZYX/FMNL2/ANK3/SSPN/FBN1/SNTB1/FMNL1/PLEC/TNNC2/SDC3/MYOM2/FN1/PDLIM4/DCN/FMNL3/AMPD3/COL4A4/ITGB6/MYH14/ACTN2/VIM/AMPD2/ITGB7/SPTBN2/ITGA4	-0.539557867539374
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/2273	47/9376	0.877647873744512	ACAT1/ALDH9A1/ME2/LDHA/PC/ACSS2/ME3/ACACA/ACACB/PCK1	-0.475671741875171
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/2273	10/9376	0.824989001319842	PAPSS1/BPNT1	-0.313222329420518
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/2273	157/9376	0.919573727585811	MAP3K5/ERN1/PRKAB1/MAPK14/PRKAG2/PRKAA2/XBP1/SDHC/IL6R/SDHD/NDUFA3/DDIT3/ADIPOR1/MT-CO1/FAS/TNFRSF1A/LEPR/IRS2/PRKAA1/BCL2L11/ITCH/JUN/PIK3CA/MLXIP/ADIPOR2/IKBKB/MAP3K11/EIF2AK3/IRS1/PPARA/MAPK10/INSR/BID/SREBF1/NR1H3	-0.574870877234912
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/2273	52/9376	0.872584520626756	IGF1/IGF1R/ALOX5/HSD17B2/CYP2J2/ADCY6/SCARB1/HSD17B7/INSR/ADCY7/ADCY3	-0.521179326861339
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/2273	20/9376	0.824989001319842	CYB5R3/CYB5R4/TGDS/GMDS	-0.443199929924778
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	51/2273	227/9376	0.926749759191893	CYBA/GSTT1/VEGFA/MAP3K5/SOD2/GSTM3/MGST1/CAT/NFE2L2/MET/MAPK14/EPHX1/SDHC/MGST2/SDHD/PDPK1/NDUFA3/MAP2K1/MT-ND5/SLC25A4/MT-CO1/PTPN11/PTPN1/SOS2/EGFR/ABL2/KEAP1/MAP2K4/MT-ND4L/JUN/MT-ND2/AHR/PIK3CA/PTPRJ/SLC26A6/IKBKB/MT-ND3/SRC/PRKD1/ARAF/GSTM4/NFKBIA/AKR1C1/MT-ATP8/NCF1/EPHX4/NCF2/MAPK10/PRKD2/PLD2/NOX4	-0.631974595042961
Organismal Systems	Digestive system	hsa04970	Salivary secretion	20/2273	93/9376	0.887084947655744	CST3/ATP1B1/ATP1A1/CALM2/VAMP2/LYZ/SLC12A2/ATP2B4/PLCB4/ITPR2/ITPR3/SLC4A2/RYR3/ADCY6/AQP5/MUC5B/ADCY7/ADCY3/CD38/KCNMA1	-0.619032695750257
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/2273	30/9376	0.824989001319842	ACO2/SDHC/SDHD/DLST/PC/PCK1	-0.54309715881032
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/2273	44/9376	0.843738751349838	TAF7/CCNH/GTF2I/GTF2E1/TAF3/ERCC3/TAF2/TAF6L/TAF4	-0.587698675915056
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	19/2273	89/9376	0.880606237363876	GABARAPL1/GLUL/SLC6A12/GNAI2/GABARAPL2/SLC38A1/GABRP/GNG11/SLC6A13/SRC/GABRE/ABAT/ADCY6/GABRQ/GLS/GNG7/ADCY7/ADCY3/GNG4	-0.640181866370645
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/2273	76/9376	0.868409475073518	ATP1B1/ATP1A1/CALM2/GNAI2/MYLK/PLCB4/ITPR2/CAMK2D/ITPR3/SLC4A2/KCNJ16/KCNQ1/ADCY6/EZR/ADCY7/ADCY3	-0.6515599629849
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	10/2273	49/9376	0.841825511550859	SLC18A2/GNAI2/CREB3L1/CREB3L2/ATF2/ATF6B/JUN/FOSB/MAOB/CREB3L4	-0.627954155799741
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	88/2273	388/9376	0.935554537579202	BACE2/MAP3K5/SLC39A6/RTN3/APP/PSENEN/SLC39A7/ERN1/CALM2/CAPN2/APOE/RTN4/APH1A/FZD6/WIPI1/XBP1/SLC39A13/SDHC/WIPI2/ATP2A2/SDHD/EIF2AK2/NDUFA3/MAP2K1/NCSTN/DDIT3/MT-ND5/ATF6/SLC39A8/SLC25A4/NRBF2/MT-CO1/ADAM10/FAS/TNFRSF1A/APH1B/SLC11A2/RB1CC1/PSEN1/SLC39A3/IRS2/SLC39A11/PLCB4/MT-ND4L/MT-ND2/PIK3CA/CSNK1E/ITPR2/APC/PIK3C3/IKBKB/WNT3/ADAM17/MT-ND3/ITPR3/ATG14/ULK2/EIF2AK3/CYBB/ARAF/PPP3CC/RYR3/SLC39A14/FZD1/MT-ATP8/KLC1/IRS1/LPL/ATG2A/PSEN2/APAF1/SLC39A9/WNT4/KLC4/BACE1/ATG2B/MAPK10/INSR/KLC3/FZD5/BID/APBB1/PSMA6/NOX4/CSF1/WNT6/DKK1/FZD8	-0.733400368630959
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2273	26/9376	0.793258655115232	LMBRD1/BTD/ABCD4/TCN2/SCARB1	-0.597135174692876
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	52/2273	235/9376	0.912753788694293	ACSL5/MAP3K5/NPR1/ACSL1/PNPLA2/SLC25A29/RPS6KA2/FGFR1/PRKAB1/RPS6KA1/MAPK14/PRKAG2/MGLL/SMARCC2/ACSL3/CREB3L1/PRKAA2/SDHC/SMARCC1/SDHD/NDUFA3/MT-ND5/MT-CO1/CREB3L2/SOS2/RHEB/COX11/SMARCD1/ATF2/KDM3B/CPT2/PRKAA1/MAP2K3/CPT1A/PPARGC1A/MT-ND4L/MT-ND2/TSC2/MT-ND3/KDM3A/SLC25A20/ADCY6/NDUFAF6/RPS6KA3/KLB/MT-ATP8/LIPE/CPT1B/ADCY7/SMARCD3/ADCY3/CREB3L4	-0.766210505083714
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/2273	41/9376	0.804867318360821	RAD50/NBN/RBBP8/ATM/TOP3A/TOPBP1/PALB2/TOP3B	-0.708319550268975
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/2273	69/9376	0.83694536365781	CTSB/NPR1/EDN1/CALM2/GNAI2/ORAI1/PTGER2/PTGER4/PLCB4/ITPR2/ITPR3/PPP3CC/ADCY6/KCNMA1	-0.768983974570375
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/2273	17/9376	0.727931471752801	CYP27A1/HSD17B4/ACOT8	-0.635115180110712
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/2273	60/9376	0.824989001319842	VEGFA/MAPK14/MAP2K1/MAPKAPK2/SPHK1/MAPKAPK3/PIK3CA/NOS3/SRC/PPP3CC/SH2D2A/SPHK2	-0.769291045046383
Cellular Processes	Cell motility	hsa04814	Motor proteins	42/2273	194/9376	0.893029331325602	DYNC2LI1/KIF12/KIF3A/KIF13B/MYO9A/MYO1E/DYNC1H1/KIF1B/MYO1C/MYO6/DNAL4/MYO5C/KIFC3/KIF9/DNALI1/DYNC1LI1/DNAL1/HOOK3/KIF3B/MYO1D/KIF1C/KIFAP3/KIF16B/MYO10/DYNC1I1/DYNC2H1/TUBD1/TNNC2/MYO5B/KIF27/KLC1/KIF13A/TUBE1/MYO9B/MYO5A/DNAH7/KLC4/MYH14/KLC3/DNAH14/KIF6/MYO1F	-0.851650449681317
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/2273	37/9376	0.780395001248499	UXS1/GALE/GFPT1/PMM2/TGDS/HKDC1/GMDS	-0.757107144684919
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/2273	23/9376	0.717381740278123	RFC1/MLH3/PMS2/MSH3	-0.767632082462674
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	8/2273	43/9376	0.767431629134736	ACAT1/SLC27A4/GOT2/ABCA1/AGPAT2/DGAT1/SCARB1/SLC27A1	-0.864646711892893
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/2273	53/9376	0.778291510679096	ATP1B1/ATP1A1/BDKRB2/AP2B1/SLC8A1/AP2A2/CLTC/ATP2B4/PLCB4/ADCY6	-0.915602277297095
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/2273	34/9376	0.727931471752801	POLR2A/POLR2J3/POLR3E/POLR3F/POLR3A/POLR3B	-0.899005364170386
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	12/2273	63/9376	0.785703810780801	GGT1/LTA4H/PTGR2/ALOX5/LTC4S/CYP2J2/TBXAS1/ALOX12/HPGD/CYP2U1/PTGS1/PLA2G6	-0.965393499422205
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	21/2273	105/9376	0.824989001319842	IGF1/ITGA3/ITGB3/SGCB/ATP2A2/SLC8A1/ITGB5/SGCE/ITGAV/ITGA2/SNTB2/SSPN/SNTB1/TGFB2/ADCY6/ITGB6/ADCY7/ITGB7/ADCY3/CACNA2D4/ITGA4	-1.02014322763597
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/2273	69/9376	0.777163551967967	SLC18A2/CALM2/CREB3L1/CREB3L2/ATF2/ATF6B/JUN/SIRT1/CAMK2D/FOSB/PPP3CC/MAOB/CREB3L4	-1.05092171146366
NA	NA	hsa04519	Cadherin signaling	88/2273	404/9376	0.89850287272458	TMC5/CDH1/TMC4/GJA1/PSENEN/TJP1/YWHAH/ABI2/FGFR1/CTNNA1/MET/MAPK14/RRAS2/ROCK2/MOB1A/MYO1E/APH1A/FZD6/MYO1C/NCKAP1/WWC1/ACTN4/JUP/AMOTL2/IGF1R/RRAS/MAP2K1/ERBB2/NCSTN/ROCK1/ADAM10/RERE/GABRP/TAOK1/APH1B/ACTR3/PCDH1/SAV1/PSEN1/PDGFRA/CREBBP/NF2/VCL/MYO1D/EP300/EGFR/STK3/LATS2/VAV2/PCDH7/MAP2K3/TAOK3/ACTR3C/CELSR2/APC/VAV1/NCKAP1L/IKBKB/WNT3/FAT1/RYK/GABRE/ATN1/KRT80/NFKBIA/LHFPL2/GABRQ/FZD1/MRAS/WTIP/PSEN2/SCN1B/WNT4/CELSR1/MAPK10/PRICKLE2/VIM/TMC8/VANGL1/FZD5/TAOK2/CDH16/USH1C/MYO1F/LEF1/ACTR3B/WNT6/FZD8	-1.17968008864346
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/2273	75/9376	0.769989734565185	GLUL/ACO2/PYCR2/GOT1/MTR/ASL/PFKP/GOT2/PC/RPE/ALDH18A1/SDS/PRPS1/CTH	-1.13129919317258
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	32/2273	158/9376	0.835431900070726	YWHAH/PPP2R5A/CCND1/GADD45B/ATRX/CDKN1B/NIPBL/SMAD3/ATM/RB1/STAG2/CCNH/ESCO1/CHEK2/CDKN1A/CREBBP/RBL2/SMAD4/PPP2R1B/STAG1/EP300/ORC3/CDC25B/TGFB2/MAU2/CDKN2A/CDC14B/CDKN2B/MAD2L2/CDKN2D/HDAC8/ATR	-1.18010403472159
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/2273	71/9376	0.755271620926616	FGFR2/FGFR1/MET/MAP2K1/ERBB2/PFKP/SCO2/PDGFRA/LDHA/EGFR/PIK3CA/HKDC1/GLS	-1.17089989773509
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/2273	91/9376	0.77059412211194	GNAI2/PDE7B/GABRP/GNG11/GABRE/ARRB2/ADCY6/GABRQ/PDE4B/GRK4/PDE7A/GNG7/ADCY7/PDE8B/ADCY3/ARRB1/GNG4	-1.24393799207266
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/2273	133/9376	0.80638022685398	SLC18A2/CALM2/PPP2R5A/GNAI2/MAPK14/CREB3L1/PPP2R3A/CREB3L2/GNG11/ATF2/PPP2R1B/ATF6B/PLCB4/ITPR2/CAMK2D/ITPR3/ARRB2/PPP3CC/CLOCK/PPP2R2D/MAPK10/GNG7/MAOB/CREB3L4/ARRB1/GNG4	-1.27213587348264
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/2273	48/9376	0.687490834433201	ATP1B1/ATP1A1/G6PC3/PLCB4/PIK3CA/SLC37A4/HKDC1/SLC5A1	-1.22787330623423
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/2273	134/9376	0.800362463967011	NPR1/EDN1/CALM2/ARHGEF12/ROCK2/MAP2K1/PPP1R12A/ROCK1/MYLK/PLCB4/KCNMB2/PPP1R12C/ITPR2/ITPR3/ARAF/GNA11/ADCY6/ARHGEF1/PPP1R12B/MYH14/ADCY7/RAMP3/ADCY3/PLA2G6/ARHGEF11/KCNMA1	-1.31666735180022
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	19/2273	102/9376	0.768372109072401	ATP1B1/ATP1A1/ATP2A2/RAP1A/SLC12A2/ATP2B4/PLCB4/ITPR2/ITPR3/SLC4A2/KCNQ1/ADCY6/CPB1/RAB3D/ADCY7/ADCY3/CD38/KCNMA1/TPCN2	-1.33052133100239
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/2273	33/9376	0.624991667666547	ACO2/GOT1/DHTKD1/DLST/GOT2	-1.22072871826614
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/2273	54/9376	0.687490834433201	GOT1/MTR/MRI1/LDHA/GOT2/SDS/CTH/BHMT2/LACC1	-1.3027753679594
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	19/2273	103/9376	0.760912185683349	PPP2R5A/SYMPK/UPF2/PPP2R3A/WDR33/WDR82/ACIN1/SMG6/RNMT/PPP2R1B/SMG1/CPSF7/CSTF1/DDX39B/PPP2R2D/SMG7/NXF1/PAPOLG/GLE1	-1.38016297627521
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/2273	39/9376	0.634606924092186	MTR/MTHFD2/CHDH/CTH/BHMT2/MTHFR	-1.29346114184994
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	20/2273	108/9376	0.763878704925779	NUP214/UPF2/KPNA4/TMEM33/NUP98/RANBP2/RANGAP1/ACIN1/THOC2/TPR/KPNA3/RANBP17/AHCTF1/KPNA1/DDX39B/NXF1/KPNA5/NUP133/GLE1/TNPO2	-1.39610624729515
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/2273	60/9376	0.687490834433201	IGF1/GNAI2/IGF1R/MAP2K1/PPP2R1B/PLCB4/ITPR2/ITPR3/ARAF/GNA11	-1.37368796463369
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	45/2273	226/9376	0.821338607508692	NPR1/ATP1B1/EDN1/ATP1A1/CALM2/GNAI2/RRAS2/RAPGEF3/ROCK2/CREB3L1/ATP2A2/RAP1A/RRAS/MAP2K1/POPDC3/PPP1R12A/CREB3L2/ROCK1/ATP2B4/CREBBP/ORAI1/PTGER2/ABCC4/EP300/VAV2/JUN/PIK3CA/VAV1/CAMK2D/ADCY6/NFKBIA/SOX9/PDE4B/F2R/ACOX3/LIPE/PTGER3/PPARA/MAPK10/TIAM1/ADCY7/PLD2/ADCY3/CREB3L4/CNGA1	-1.53793802847862
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/2273	67/9376	0.677229777202855	ALDH3B1/FBP1/ALDH9A1/G6PC3/PFKP/LDHA/MINPP1/ADPGK/HKDC1/ACSS2/PCK1	-1.49983608060707
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/2273	36/9376	0.572909028694334	CRYL1/SORD/FGGY/GUSB/RPE	-1.4523211150575
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/2273	47/9376	0.614353511621159	IRS2/PIK3CA/IKBKB/HKDC1/IRS1/MAPK10/INSR	-1.49928850841674
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	47/2273	238/9376	0.814589980294802	C1QA/MX1/C1QB/STAT1/STAT3/IFNAR1/MAPK14/IL6ST/JAK1/C1QC/IL6R/EIF2AK2/TLR3/ADAR/STAT2/TNFRSF1A/OAS1/C2/FCGR2A/C3/EGFR/JUN/PIK3CA/C3AR1/IKBKB/ADAM17/OAS2/CASP1/CYBB/IRAK4/SYK/MX2/NFKBIA/CXCL10/IRF9/MASP1/TLR4/C8B/TRAF6/TMPRSS2/HBEGF/TLR7/C5AR1/MAPK10/MAVS/F13A1/TLR2	-1.6389305492821
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/2273	19/9376	0.434204737536759	DHTKD1/DLST	-1.39647202848863
NA	NA	hsa04382	Cornified envelope formation	42/2273	217/9376	0.798376452890169	LAMB3/CLDN10/CLDN3/CLDN4/CLDN1/HAL/TJP1/PPP2R5A/DST/CLDN7/KDSR/ELOVL1/SPTLC2/S100A1/JUP/SPTLC3/LAMA5/SLC27A4/PPP2R3A/S100A13/SPTLC1/ST14/OCLN/S100A9/PPL/PPP2R1B/UGCG/CLDN12/S100A2/GBA2/KAZN/LAMC2/PLEC/CLDN23/KRT80/PPP2R2D/CLDN16/COL4A4/COL17A1/SLC27A1/CLDN8/CLDN9	-1.69985366925717
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	25/2273	138/9376	0.747272646123045	IGF1/YWHAH/CALM2/PPP2R5A/RPS6KA2/RPS6KA1/MAPK14/IGF1R/SLK/FBXW11/MAP2K1/PPP2R1B/CPEB4/ITPR2/CAMK2D/ITPR3/REC8/PPP3CC/CPEB2/ADCY6/RPS6KA3/MAD2L2/ADCY7/ADCY3/PGR	-1.69187106562296
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/2273	26/9376	0.475955193069139	HNF1B/HES1/HHEX	-1.51360913081015
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/2273	110/9376	0.712490501139863	IGF1/RPS6KA2/RPS6KA1/GNAI2/MAPK14/IGF1R/MAP2K1/CPEB4/PIK3CA/CDC25B/ARAF/CPEB2/ADCY6/RPS6KA3/MAD2L2/MAPK10/ADCY7/ADCY3/PGR	-1.71580070145496
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/2273	115/9376	0.717381740278123	BCL2/GNAI2/CREB3L1/MAP2K1/CREB3L2/GNG11/PLCB4/PIK3CA/ITPR2/CAMK2D/ITPR3/KCNQ1/GNA11/ADCY6/GNG7/ADCY7/ADCY3/CREB3L4/GNG4/JAK2	-1.72498230582122
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/2273	154/9376	0.749990001199856	BCL2/ATP1B1/ATP1A1/CALM2/PPP2R5A/GNAI2/MAPK14/RAPGEF3/CREB3L1/ATP2A2/PPP2R3A/SLC8A1/POPDC3/CREB3L2/ATP2B4/ATF2/PPP2R1B/ATF6B/PLCB4/CAMK2D/KCNQ1/ADCY6/PPP2R2D/SCN1B/ADCY7/ADCY3/CREB3L4/CACNA2D4	-1.76957766532068
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	16/2273	97/9376	0.680403300057601	RASD1/CALM2/GNAI2/PER2/GNG11/PLCB4/CAMK2D/ITPR3/RYR3/ADCY6/GNG7/ADCY7/PER3/ADCY3/PER1/GNG4	-1.78978974255107
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	99/2273	480/9376	0.850769907611087	GPX3/BCL2/MAP3K5/CAT/HSPA5/APP/ERN1/CALM2/CAPN2/DERL1/MAPK14/UBE2L6/ATXN2/FZD6/WIPI1/LRRK2/XBP1/SDHC/DNAL4/WIPI2/GPX1/ATP2A2/OPTN/SDHD/IFT57/NDUFA3/MAP2K1/DDIT3/MT-ND5/ATF6/SLC25A4/NRBF2/MT-CO1/DNALI1/UBE2G1/FAS/TNFRSF1A/BCL2L1/DNAL1/RB1CC1/MFN1/PINK1/SQSTM1/PSEN1/SPG11/UBE2G2/GPX7/ATXN2L/MAP2K3/PLCB4/MT-ND4L/MT-ND2/CSNK1E/ITPR2/ATXN1L/APC/PIK3C3/CAMK2D/WNT3/MT-ND3/WDR41/ITPR3/ATG14/PRNP/ULK2/EIF2AK3/ATXN1/CYBB/ARAF/PPP3CC/RYR3/HIP1/C9orf72/FZD1/MT-ATP8/KLC1/ATG2A/PSEN2/APAF1/DNAH7/UBA7/WNT4/KLC4/ATG2B/MAPK10/ZFYVE1/KLC3/FZD5/DNAH14/BID/PSMA6/ALS2/FIG4/NOX4/CSF1/SPTBN2/WNT6/DKK1/FZD8	-1.89864639124794
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/2273	82/9376	0.653954696168167	GSTT1/CDA/GSTM3/MGST1/NME3/MGST2/GUSB/TYMP/NME7/DPYD/GSTM4/RRM2B/CDADC1	-1.7803402097082
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/2273	28/9376	0.441958393564201	MOCOS/FPGS/MOCS1	-1.67282570293187
NA	NA	hsa04081	Hormone signaling	41/2273	219/9376	0.772249978404418	NPR1/IGF1/STAT3/GNAI2/RAPGEF3/ITGB3/IGF1R/APPL1/CSH1/ADIPOR1/LEPR/ITGAV/SMAD4/GNG11/THRA/IRS2/SMAD1/PLCB4/HAMP/PIK3CA/GNA15/ADIPOR2/SRC/NPR3/GNA11/ACVR1/ADCY6/IRS1/BMPR1B/GNG7/INSR/PRL/PRLR/BMPR1A/ADCY7/RAMP3/MC1R/STAT5A/ADCY3/GNG4/JAK2	-1.92916034371015
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	25/2273	143/9376	0.721144231922938	HLA-DMA/HLA-DRA/HLA-DMB/C1QA/HLA-DRB1/C1QB/HLA-DPA1/HLA-DPB1/C1QC/ACTN4/FCGR3A/HLA-DQA2/HLA-DQB1/C2/FCGR2A/C3/HLA-DQA1/HLA-DOB/HLA-DOA/CD86/CD40/FCGR1A/C8B/IL10/TRIM21	-1.90081863891048
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/2273	63/9376	0.589277858085601	XPC/POLR2A/RFC1/CETN2/CCNH/POLR2J3/ERCC3/ERCC6/ERCC5	-1.85028248667243
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/2273	41/9376	0.503042073975513	CHDH/SDS/CTH/SRR/MAOB	-1.80392649610157
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/2273	115/9376	0.681512653264217	SLC18A2/DUSP1/APP/GNAI2/RAPGEF3/MAP2K1/ALOX5/GNG11/CYP2J2/PLCB4/ALOX12/ITPR2/ITPR3/ARAF/HTR2B/GNG7/MAOB/PTGS1/GNG4	-1.94391203982298
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2273	29/9376	0.426718448958539	CALM2/PDE6B/CNGA1	-1.74902208010925
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	51/2273	268/9376	0.784970878121491	SLC18A2/MAP3K5/SLC39A6/DUSP1/HSPA5/SLC39A7/ERN1/CALM2/NFE2L2/GNAI2/UBE2L6/LRRK2/XBP1/SLC39A13/SDHC/SDHD/NDUFA3/DDIT3/MT-ND5/ATF6/SLC39A8/SLC25A4/MT-CO1/UBE2G1/BCL2L1/SLC11A2/MFN1/PINK1/UBE2G2/SLC39A3/SLC39A11/KEAP1/MT-ND4L/MT-ND2/ITPR2/CAMK2D/MT-ND3/ITPR3/EIF2AK3/RYR3/SLC39A14/MT-ATP8/KLC1/APAF1/UBA7/SLC39A9/KLC4/MAPK10/KLC3/MAOB/PSMA6	-2.0203081516109
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/2273	116/9376	0.675637544184353	SLC1A1/DLGAP1/GLUL/GNAI2/SLC38A1/SHANK2/GNG11/PLCB4/LZTS3/ITPR2/ITPR3/PPP3CC/ADCY6/GLS/GNG7/ADCY7/PLD2/ADCY3/GNG4	-1.98846764984402
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	10/2273	70/9376	0.589277858085601	GSTT1/GSTM3/CYP3A5/MGST1/EPHX1/GSTK1/MGST2/SULT1A1/GSTM4/HSD11B1L	-1.95110238956398
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/2273	65/9376	0.571146231682967	SPP1/MAP2K1/PLCB4/PIK3CA/ITPR2/ITPR3/ARRB2/GNA11/ARRB1	-1.96260180658165
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	37/2273	205/9376	0.74450226948376	CYBA/CTSD/MPC1/MAPK14/SMAD3/GFPT1/SDHC/TGFBR2/ATP2A2/SDHD/NDUFA3/MT-ND5/SLC25A4/PDK4/MT-CO1/CPT2/PLCB4/MT-ND4L/MT-ND2/PIK3CA/NOS3/CAMK2D/MT-ND3/TGFB2/CYBB/SP1/MT-ATP8/IRS1/MMP9/NCF1/NCF2/PPARA/MAPK10/NCF4/CPT1B/INSR/TGFBR1	-2.09228132813846
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	72/2273	368/9376	0.807054457812889	GPX3/BCL2/MAP3K5/CAT/HSPA5/ERN1/ANXA7/NUP214/DERL1/MAPK14/ATXN2/MATR3/ANG/WIPI1/XBP1/SDHC/DNAL4/WIPI2/GPX1/OPTN/SDHD/NDUFA3/SETX/DDIT3/MT-ND5/ATF6/NUP98/NRBF2/MT-CO1/DNALI1/RANBP2/ANXA11/TNFRSF1A/BCL2L1/DNAL1/RB1CC1/PINK1/TPR/SQSTM1/SPG11/GPX7/ATXN2L/MAP2K3/MT-ND4L/MT-ND2/PIK3C3/MT-ND3/WDR41/ITPR3/ATG14/ULK2/CASP1/EIF2AK3/PPP3CC/C9orf72/NXF1/MT-ATP8/KLC1/ATG2A/APAF1/DNAH7/HDAC6/KLC4/ATG2B/KLC3/DNAH14/BID/NUP133/PSMA6/GLE1/ALS2/FIG4	-2.13603772405097
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/2273	37/9376	0.445940000713428	ALDH3B1/GOT1/GOT2/MAOB	-1.91016956093363
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/2273	103/9376	0.640768156364925	SLC1A1/ATP1B1/SLC15A1/ATP1A1/SLC3A1/PRCP/SLC8A1/COL18A1/SLC7A7/SLC7A8/KCNQ1/KCNK5/CPB1/COL4A4/COL17A1/COL22A1	-2.07370874128939
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/2273	66/9376	0.562492500899892	SRD5A3/CYP3A5/HSD17B12/HSD17B11/HSD17B2/AKR1C1/HSD11B1L/DHRS11/HSD17B7	-2.01765578734001
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/2273	31/9376	0.399188226445085	ALDH9A1/GUSB/HSD17B14	-1.89537032742143
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	10/2273	73/9376	0.565060959808111	GSTT1/ALDH3B1/GSTM3/CYP3A5/MGST1/GSTK1/MGST2/GSTM4/MAOB/FMO5	-2.11029300828574
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	34/2273	195/9376	0.719221180637811	CYBA/MAPK14/CLCN3/ITGB3/HDAC7/FCGR3A/MAP2K1/SLC25A4/ITGB2/FCGR2A/C3/PLCB4/PIK3CA/SRC/FPR3/ITGAM/SELPLG/CASP1/CYBB/SYK/ATG7/TLR4/HDAC8/FCGR1A/NCF1/HDAC10/TLR7/HDAC6/NCF2/ITGAL/C5AR1/NCF4/SIGLEC9/TLR2	-2.24130574466478
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9/2273	68/9376	0.545948603814601	DHRS3/CYP3A5/RDH11/ALDH1A1/RDH13/ALDH1A3/DHRS4/DGAT1/RETSAT	-2.12566946121268
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/2273	79/9376	0.574359431298624	GSTT1/ALDH3B1/GSTM3/CYP3A5/MGST1/EPHX1/GSTK1/MGST2/GSTM4/AKR1C1/HSD11B1L	-2.14906521001164
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/2273	90/9376	0.595825389842108	ATP1B1/ABCC3/ATP1A1/EPHX1/NCEH1/HMGCR/ABCC4/SLC4A2/ADCY6/SCARB1/ADCY7/SLC5A1/ADCY3	-2.17941728952858
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/2273	26/9376	0.317303462046093	ACOX3/PLA2G6	-1.97184610886878
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/2273	149/9376	0.664420672203899	GNAI2/MAPK14/MGLL/NDUFA3/MT-ND5/GABRP/GNG11/DAGLB/FAAH/PLCB4/MT-ND4L/MT-ND2/ITPR2/MT-ND3/ITPR3/GABRE/ADCY6/GABRQ/MAPK10/NAPEPLD/GNG7/ADCY7/ADCY3/GNG4	-2.33572937379727
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	59/2273	323/9376	0.753472926902022	VEGFA/BCL2/TNC/FOXP1/STAT3/CCND1/ERBB3/EFNA1/TIMP3/CYP24A1/MET/ITGB3/CDKN1B/ATM/CD44/MCL1/DICER1/ST14/MAP2K1/ERBB2/ROCK1/MDM4/NOTCH2/SOS2/CDKN1A/PDGFRA/CREBBP/IRS2/BCL2L11/EP300/EGFR/SPRY2/PIK3CA/CDC25B/APC/PDGFA/SIRT1/IKBKB/WNT3/BMPR2/TGFB2/SLC7A1/CDKN2A/PDGFB/SHC4/IRS1/MMP9/EFNA5/MIR29A/EZR/GLS/ZEB2/MAPK7/VIM/BCL2L2/RECK/MARCKS/NOTCH1/SLC45A3	-2.55055133652474
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2273	30/9376	0.274996333773281	CYP2J2/PLA2G6	-2.24984391966353
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	20/2273	138/9376	0.597818116898436	ATP6V1D/ATP6AP1/ATP6V0A2/ATP6V0B/ATP6V0A1/SDHC/SDHD/NDUFA3/MT-ND5/ATP6V1C1/MT-CO1/ATP6V1H/ATP6V0E2/COX11/TCIRG1/MT-ND4L/MT-ND2/MT-ND3/MT-ATP8/ATP6V1E2	-2.69238719394251
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	23/2273	154/9376	0.61606321527131	DHRS3/RDH11/NME3/RFK/VKORC1/IDO1/VKORC1L1/COASY/MTHFD2/RDH13/GUSB/NME7/COQ2/PMM2/COQ7/PNPO/FPGS/MOCS1/KYNU/AK9/NADSYN1/IDO2/CMPK2	-2.71751514904023
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	54/2273	308/9376	0.723204644014147	GPX3/MAP3K5/SOD2/ERN1/CREB3L1/WIPI1/POLR2A/SDHC/DNAL4/WIPI2/AP2B1/REST/GPX1/SDHD/IFT57/NDUFA3/MT-ND5/SLC25A4/NRBF2/MT-CO1/DNALI1/CREB3L2/AP2A2/CLTC/DNAL1/RB1CC1/CREBBP/POLR2J3/GPX7/EP300/PLCB4/PPARGC1A/MT-ND4L/MT-ND2/PIK3C3/MT-ND3/ATG14/ULK2/HIP1/SP1/MT-ATP8/SIN3A/KLC1/ATG2A/APAF1/DNAH7/KLC4/ATG2B/MAPK10/KLC3/DNAH14/PSMA6/TAF4/CREB3L4	-2.79410582418924
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2273	41/9376	0.301825244385308	GABRP/GABRE/GABRQ	-2.53433112665663
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	46/2273	275/9376	0.689990801103867	CYBA/LAMC1/C1QA/C1QB/HSPA5/MAPK14/CREB3L1/SDHC/C1QC/SDHD/NDUFA3/DDIT3/MT-ND5/SLC25A4/HSPA1B/MT-CO1/CREB3L2/CAV2/ATF2/HSPA1A/ATF6B/MT-ND4L/MT-ND2/PIK3CA/ITPR2/MT-ND3/ITPR3/PRNP/EIF2AK3/CYBB/PPP3CC/RYR3/MT-ATP8/KLC1/C8B/NCF1/NCAM1/APAF1/NCF2/KLC4/MAPK10/NCF4/KLC3/PSMA6/NOTCH1/CREB3L4	-2.95162254766694
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/2273	46/9376	0.269018152604296	CP/BLVRA/GUSB	-2.81131257286473
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/2273	46/9376	0.269018152604296	PSMB9/PSMB10/PSMA6	-2.81131257286473
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/2273	36/9376	0.114581805738867	RFC1	-3.01086097711303
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/2273	87/9376	0.331892126967752	ATP1B1/ATP1A1/ASPH/ATP2A2/SLC8A1/MT-CO1/CACNA2D4	-3.54149133169652
Human Diseases	Substance dependence	hsa05034	Alcoholism	23/2273	191/9376	0.496721126449119	SLC18A2/CALM2/NTRK2/GNAI2/HDAC7/CREB3L1/MAP2K1/CREB3L2/SOS2/GNG11/ATF2/ATF6B/FOSB/CAMKK2/ARAF/SHC4/HDAC8/HDAC10/HDAC6/GNG7/MAOB/CREB3L4/GNG4	-3.97512007861631
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/2273	86/9376	0.239822384104605	SCNN1A/PLCB4/ITPR3/ADCY6/KCNK5	-4.0060917782903
NA	NA	hsa04082	Neuroactive ligand signaling	20/2273	199/9376	0.414567337346654	SLC1A1/SLC18A2/SLC6A12/GNAI2/HRH1/GABRP/OGFR/GNG11/PLCB4/SLC6A13/GABRE/GNA11/ADCY6/GABRQ/HTR2B/GNG7/ADCY7/ADCY3/P2RY11/GNG4	-4.72190853244032
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/2273	243/9376	0.407401975960416	DDX42/SF1/PRPF38B/U2SURP/WBP11/SNRNP27/SRSF10/SLU7/HSPA1B/PRPF8/ACIN1/THOC2/U2AF1L4/SF3A1/TRA2B/PRPF18/HSPA1A/RBM25/DDX5/DDX23/CRNKL1/DHX8/DDX39B/BUD13	-5.29445249289221
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/2273	183/9376	0.270488197154046	SBDS/REXO2/BMS1/XRN1/LSG1/UTP14C/HEATR1/FCF1/NXF1/SNORD3D/SNORD3A/SNORD3B-2	-5.63759257257137
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	38/2273	370/9376	0.423643000677757	EDNRB/RXFP1/NR3C1/EDN1/PGRMC1/F2RL1/NMB/BDKRB2/PGRMC2/HRH1/CSH1/GABRP/LEPR/OGFR/PTGER2/THRA/C3/PTGER4/TSPO/C3AR1/FPR3/GABRE/LPAR1/GABRQ/F2R/LPAR6/PTGER3/HTR2B/C5AR1/CYSLTR1/PRL/PRLR/P2RX7/PTAFR/MC1R/S1PR4/P2RY11/LPAR2	-6.39868765509636
Genetic Information Processing	Translation	hsa03010	Ribosome	1/2273	222/9376	0.0185808333630595	MRPL33	-8.37124431851663
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/2273	449/9376	0.0734956794048857	CALM2/SLC8A1/CAMK2D/ARRB2/RGS2/GNG7/ADCY3/ARRB1	-11.3810491991703