category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	41/571	224/9376	3.00550412809607	HLA-B/HLA-A/B2M/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/PIK3R3/TGFBR2/ICAM1/HLA-DMB/NFKBIA/AKT3/ADCY4/ETS1/ELK4/CDKN1A/ETS2/TNFRSF1A/ZFP36/HLA-DQA2/HLA-DQA1/CCND3/ANAPC16/ITGB2/CDKN2C/NFATC1/RELA/MAP3K3/CD4/JUN/CREBBP/CREB5/CREB1/RELB/STAT5A/IKBKB	7.73621580153203
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	38/571	205/9376	3.04376575114263	HLA-B/HLA-A/B2M/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/PIK3R3/ENTPD1/VIM/GADD45B/ICAM1/HLA-DMB/NFKBIA/AKT3/TAPBP/CDKN1A/STAT3/HLA-DQA2/OAS1/OAS2/HLA-DQA1/CCND3/TAP1/POLK/CD58/RELA/JUN/IFNAR1/DDB2/PLCG2/RELB/IRF7/IKBKB	7.5342272094047
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	22/571	82/9376	4.40545042928538	HLA-B/HLA-A/B2M/HLA-E/CD74/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/CTSS/HSPA1A/HLA-DMB/TAPBP/CTSB/HLA-DQA2/HLA-DQA1/TAP1/CD4/CREB1	7.88713305239813
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	33/571	180/9376	3.01039112667834	HLA-B/HLA-A/B2M/HLA-E/CD74/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/PIK3R3/SP100/TNFRSF14/HLA-DMB/NFKBIA/AKT3/TAPBP/SOCS3/TNFRSF1A/HLA-DQA2/BST2/OAS1/OAS2/HLA-DQA1/TAP1/RELA/IFNAR1/CCL2/IRF7/IFIH1/IKBKB	6.93515771788864
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/571	70/9376	4.45694270703027	HLA-B/HLA-A/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/SNTB2/ABL2/ICAM1/HLA-DMB/HLA-DQA2/HLA-DQA1/ITGB2/ABL1/FYN	7.39262522728095
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/571	101/9376	3.57670232872674	PIK3R3/PLCB4/TGFBR2/PLCB1/ICAM1/VEGFC/THBD/AKT3/SERPINE1/NOX4/STAT3/FOXO1/NFATC1/EDN1/RELA/JUN/NOS3/CCL2/PLCD3/PLCG2/SELE/STAT5A	6.62990018270805
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	30/571	173/9376	2.84745350920705	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/TNFSF10/PIK3R3/ICAM1/CASP1/HLA-DMB/NFKBIA/AKT3/IL33/SOCS3/TNFRSF1A/HLA-DQA2/OAS1/TNFRSF10B/OAS2/HLA-DQA1/CCND3/MX1/RELA/IFNAR1/CREBBP/CCL2/TNFRSF10A/IRF7/IFIH1/IKBKB	6.24555260948693
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/571	137/9376	3.11626420545336	CTSS/TNFSF10/PIK3R3/CTSD/GADD45B/IL3RA/NFKBIA/AKT3/CTSB/DAB2IP/TUBA1A/TNFRSF1A/CTSZ/ITPR1/TNFRSF10B/LMNA/CTSH/CTSF/CFLAR/PARP4/RELA/JUN/CTSO/TNFRSF10A/CAPN2/IKBKB	6.35413881745209
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/571	44/9376	5.22464575704506	HLA-B/HLA-A/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/HLA-DMB/HLA-DQA2/HLA-DQA1/ICA1	7.15267156933352
Human Diseases	Immune disease	hsa05330	Allograft rejection	13/571	39/9376	5.47343841214244	HLA-B/HLA-A/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/HLA-DMB/HLA-DQA2/HLA-DQA1	7.12867965215039
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	19/571	88/9376	3.54529533513772	CD59/A2M/VWF/CLU/CFI/C1QB/C1QA/THBD/SERPINE1/F8/C1QC/F2RL3/ITGB2/CFH/VSIG4/SERPINA5/ITGAM/PLAT/SERPINA1	6.10882137652225
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/571	45/9376	4.74364662385678	HLA-B/HLA-A/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/HLA-DMB/HLA-DQA2/HLA-DQA1	6.41026556298668
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	21/571	112/9376	3.07880910683012	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/ITGA6/HLA-DPB1/LY96/GNAI2/HSPA1A/LAMA5/HLA-DMB/NFKBIA/AKT3/TNFRSF1A/STAT3/HLA-DQA2/HLA-DQA1/RELA/LAMA4/IKBKB/LAMB2	5.63590106900719
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	30/571	201/9376	2.45079331886975	LMO2/SMAD1/ERG/DDX5/TGFBR2/TSPAN7/GADD45B/JMJD1C/DUSP6/HHEX/PBX3/ETV6/ELK4/LYL1/CDKN1A/ID2/BMI1/KMT2A/POLK/CDKN2C/FOXO1/RELA/DDB2/HPGD/ITGAM/KLF3/CD14/MEF2C/PLAT/REL	5.29467797624638
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/571	142/9376	2.7752645470018	PIK3R3/KLF2/GSTT1/MGST2/MEF2A/ICAM1/THBD/DUSP1/AKT3/NFE2L2/NQO1/TNFRSF1A/BMPR2/EDN1/SQSTM1/RELA/JUN/NOS3/CCL2/SELE/MEF2C/SUMO3/PLAT/IKBKB	5.42814361300914
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	19/571	99/9376	3.15137363123353	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/CFI/C1QB/C1QA/ICAM1/HLA-DMB/FCGR3A/HLA-DQA2/C1QC/HLA-DQA1/ITGB2/CFH/FPR3/PTAFR/ITGAM	5.47985002235461
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/571	196/9376	2.42953643804282	HLA-B/HLA-A/HLA-E/HLA-C/CLEC2B/HLA-F/PIK3R3/ANGPT2/ICAM1/LEF1/GNG11/HIF1A/NFKBIA/AKT3/CDKN1A/TNFRSF1A/ZFP36/STAT3/ITPR1/NFATC1/RELA/JUN/BECN1/IFNAR1/CREBBP/CREB1/PLCG2/IRF7/IKBKB	5.15039973498379
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	20/571	109/9376	3.01290187824355	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/AHR/TGFBR2/HLA-DMB/HIF1A/NFKBIA/RORA/STAT3/HLA-DQA2/HLA-DQA1/NFATC1/RELA/CD4/JUN/STAT5A/IKBKB	5.38276332520198
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/571	157/9376	2.61469987841199	HLA-B/HLA-A/HLA-E/HLA-C/HLA-F/PIK3R3/TGFBR2/GADD45B/ZFP36L2/AKT3/ETS1/RBL2/MRAS/SERPINE1/CDKN1A/HIPK3/ITPR1/CCND3/FOXO1/NFATC1/SQSTM1/RELA/FBXW11/TRAF3IP2/CAPN2	5.19563631275086
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	21/571	119/9376	2.89770268878129	PIK3R3/ICAM1/BCL3/VEGFC/MLKL/NFKBIA/AKT3/JUNB/SOCS3/DAB2IP/TNFRSF1A/IRF1/CFLAR/EDN1/RELA/JUN/CREB5/CREB1/CCL2/SELE/IKBKB	5.30524608968886
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	21/571	122/9376	2.82644770463093	PIK3R3/GNAI2/PLCB4/PLCB1/CSH2/CSH1/AKT3/SOCS2/ADCY4/JUNB/SOCS3/STAT3/ITPR1/GNA11/CREBBP/CREB5/CREB1/SOS1/SHC1/PLCG2/STAT5A	5.17084383495473
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/571	203/9376	2.34575931948962	SPP1/VWF/ITGA6/EMP2/THBS1/PIK3R3/EMP1/LAMA5/VEGFC/AKT3/MYL12A/MYL12B/TNC/PARVB/CCND3/RAP1A/ITGB4/TNXB/PIP5K1C/JUN/LAMA4/PDGFD/SOS1/SHC1/CAPN2/RELN/ITGA1/FYN/LAMB2	4.93626800002609
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/571	54/9376	3.95303885321398	HLA-B/HLA-A/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/HLA-DMB/HLA-DQA2/HLA-DQA1	5.5417956039093
NA	NA	hsa04518	Integrin signaling	24/571	154/9376	2.55901016671595	SPP1/VWF/ITGA6/THBS1/PIK3R3/ICAM1/LIMS2/LAMA5/VEGFC/AKT3/TNC/PARVB/LIMS1/CCND3/NPNT/ITGB2/ITGB4/TNXB/LAMA4/PDGFD/ITGAM/RELN/ITGA1/LAMB2	4.96747581092752
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/571	155/9376	2.54250042370488	HLA-B/HLA-A/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/HLA-DPB1/CTSS/THBS1/HLA-DMB/FCGR3A/TUBA1A/HLA-DQA2/HLA-DQA1/MSR1/STX7/TAP1/ITGB2/DYNC1LI2/ITGAM/CD14	4.93106971109847
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/571	109/9376	2.86225678433137	PIK3R3/NFKBIA/AKT3/SOCS3/TNFRSF1A/NR1H2/RPS6KA2/STAT3/CPT1A/RPS6KA3/FOXO1/INSR/RELA/PRKAG2/NOS3/CREB5/CREB1/MLXIP/IKBKB	4.97991860862809
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/571	160/9376	2.4630472854641	HLA-B/HLA-A/HLA-E/HLA-DRA/HLA-C/HLA-DPA1/HLA-DRB1/HLA-F/HLA-DMA/ITGA6/HLA-DPB1/ICAM1/HLA-DMB/CLDN5/CLDN15/HLA-DQA2/HLA-DQA1/ITGB2/CD58/CD4/ALCAM/ITGAM/SELE/CD34	4.75320048912601
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/571	103/9376	2.86956965296788	C1QB/PIK3R3/GNAI2/PLCB4/TGFBR2/C1QA/PLCB1/NFKBIA/AKT3/SERPINE1/TNFRSF1A/C1QC/CFLAR/GNA11/RELA/JUN/CCL2/IKBKB	4.85835387056091
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	22/571	142/9376	2.54399250141832	PIK3R3/TGFBR2/NFKBIA/AKT3/FCGR3A/JUNB/SOCS3/TNFRSF1A/ITPR1/TREM2/TYROBP/NFATC1/SQSTM1/RELA/JUN/IFNAR1/CREB1/FOSL2/PLCG2/RELB/IKBKB/FYN	4.72099386497766
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	21/571	133/9376	2.5926813531201	TNFSF10/PIK3R3/KLF2/TGFBR2/GADD45B/GABARAPL2/SOD2/AKT3/RBL2/CDKN1A/STAT3/PLK3/FOXO1/INSR/PRKAG2/S1PR1/CREBBP/SOS1/CAT/SGK3/IKBKB	4.71071957209614
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	15/571	77/9376	3.19876270839493	PIK3R3/TGFBR2/GADD45B/NFKBIA/AKT3/CDKN1A/BCR/POLK/RELA/DDB2/ABL1/SOS1/SHC1/STAT5A/IKBKB	4.93338050731574
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	15/571	78/9376	3.15775293008218	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/HLA-DMB/NFKBIA/FCGR3A/HLA-DQA2/HLA-DQA1/ITGB2/RELA/JUN/MARCKSL1/ITGAM	4.87296461333356
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	32/571	253/9376	2.07687781646512	PIK3R3/PLCB4/PLCB1/CASP1/NFKBIA/AKT3/MYL12A/MYL12B/TNFRSF1A/ELMO1/ITPR1/BCL10/CYTH1/RRAGB/CAPNS1/NAIP/TNIP1/FOXO1/SQSTM1/RELA/UBE2D1/JUN/BECN1/CAST/FBXW11/CASP4/TIFA/PLCD3/PLCG2/CAPN2/CD14/IKBKB	4.42177730148477
Human Diseases	Immune disease	hsa05310	Asthma	9/571	32/9376	4.61821366024518	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/PRG2/HLA-DMB/HLA-DQA2/HLA-DQA1	5.22085696871285
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	17/571	100/9376	2.79145359019264	HLA-DRA/HLA-DPA1/CD59/HLA-DRB1/HLA-DMA/ITGA6/HLA-DPB1/HLA-DMB/IL3RA/CD9/HLA-DQA2/HLA-DQA1/CD4/ITGAM/CD14/CD34/ITGA1	4.58631842172087
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/571	248/9376	2.05253940455342	LY96/TNFSF10/RHOJ/S100A10/CASP1/LEF1/MLKL/NFKBIA/AKT3/MYL12A/MYL12B/PODXL/TUBA1A/TNFRSF1A/ELMO1/TNFRSF10B/CYTH1/NAIP/FHOD1/STX10/RELA/JUN/DYNC1LI2/CASP4/PIK3C2A/ARL8A/TNFRSF10A/CD14/KLC1/DYNLT3/IKBKB	4.27775000660034
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	29/571	227/9376	2.09774952359644	HLA-B/HLA-A/B2M/HLA-E/HLA-C/HLA-F/PIK3R3/GNAI2/PLCB4/PLCB1/GNG11/NFKBIA/AKT3/ADCY4/TAPBP/CDKN1A/TNFRSF1A/STAT3/ITPR1/TAP1/NFATC1/GNA11/RELA/ARHGEF12/CREB5/CREB1/CCL2/SOS1/IKBKB	4.26352078231464
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	28/571	216/9376	2.12855938249984	LY96/TNFSF10/PIK3R3/ABCG1/PLCB4/PLCB1/HSPA1A/ICAM1/CASP1/SOD2/NFKBIA/AKT3/NFE2L2/TNFRSF1A/STAT3/ITPR1/TNFRSF10B/RAP1A/NFATC1/RELA/JUN/NOS3/CCL2/TNFRSF10A/SELE/CD14/IRF7/IKBKB	4.27309518108665
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	38/571	333/9376	1.87378972667939	HLA-B/HLA-A/HLA-E/HLA-C/SPP1/VWF/HLA-F/ITGA6/THBS1/PIK3R3/LAMA5/AKT3/RBL2/CDKN1A/FZD4/TNFRSF1A/TNC/CCND3/IRF1/MFNG/MX1/FOXO1/PPP2R5A/ITGB4/TNXB/RELA/MAGI1/IFNAR1/LAMA4/CREBBP/CREB5/CREB1/SOS1/RELN/IKBKB/ITGA1/LAMB2/NOTCH4	4.13439339174705
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/571	66/9376	3.23430451626599	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/HLA-DMB/RORA/STAT3/HLA-DQA2/HLA-DQA1/NFATC1/RELA/JUN	4.63851005991378
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	25/571	187/9376	2.1952293096828	CARD16/IFI16/TXNIP/PLCB4/PLCB1/GABARAPL2/CASP1/NFKBIA/CTSB/GBP2/NAMPT/ITPR1/OAS1/OAS2/NAIP/RELA/CARD6/JUN/IFNAR1/CASP4/CCL2/GBP3/GBP1/IRF7/IKBKB	4.20413762173545
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	22/571	156/9376	2.31568548206026	PIK3R3/NFKBIA/AKT3/CLDN5/SOCS3/CDKN1A/YWHAH/TNFRSF1A/IFIT1/CLDN15/STAT3/CD81/OAS1/OAS2/MX1/CFLAR/RELA/IFNAR1/SOS1/PIAS1/IRF7/IKBKB	4.21976177096239
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/571	105/9376	2.6585272287549	PIK3R3/CASP1/BCL3/NFKBIA/AKT3/MRAS/ITPR1/BCL10/IRF1/PLK3/NFATC1/RELA/JUN/ARHGEF12/PLCG2/RELB/IKBKB	4.35204098939038
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	24/571	181/9376	2.17727936836605	CD74/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/CTSS/CTSD/HLA-DMB/SPHK1/AKT3/FCGR3A/TNFRSF1A/HLA-DQA2/BCL10/HLA-DQA1/ITGB2/PLK3/RELA/ARHGEF12/CREBBP/CREB1/ITGAM/CD14	4.07269573645015
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/571	89/9376	2.76746886007202	SPP1/VWF/ITGA6/THBS1/LAMA5/TNC/HSPG2/NPNT/ITGB4/TNXB/AGRN/LAMA4/RELN/ITGA1/LAMB2	4.26626731286549
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/571	130/9376	2.39989222686245	PIK3R3/GNAI2/PLCB4/TGFBR2/PLCB1/RXFP1/GNG11/VEGFC/NFKBIA/AKT3/ADCY4/EDN1/RELA/JUN/NOS3/CREB5/CREB1/SOS1/SHC1	4.09287372500295
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	19/571	133/9376	2.34575931948962	HLA-B/HLA-A/HLA-E/HLA-C/TNFSF10/PIK3R3/ICAM1/FCGR3A/TNFRSF10B/TYROBP/ITGB2/NFATC1/SH3BP2/IFNAR1/SOS1/SHC1/PLCG2/TNFRSF10A/FYN	3.98039115183417
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/571	93/9376	2.64843794135925	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/HLA-DMB/NFKBIA/HLA-DQA2/HLA-DQA1/NFATC1/RELA/CD4/JUN/STAT5A/IKBKB	4.06826199078034
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/571	106/9376	2.47853814889469	PIK3R3/FOLH1/ERG/LEF1/NFKBIA/AKT3/CDKN1A/FOXO1/RELA/CREBBP/CREB5/CREB1/PDGFD/SOS1/PLAT/IKBKB	3.89838396755074
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	38/571	362/9376	1.72367949995646	SPP1/VWF/ITGA6/THBS1/PIK3R3/ANGPT2/CSH2/GNG11/LAMA5/CSH1/VEGFC/IL3RA/AKT3/OSMR/RBL2/CDKN1A/YWHAH/TNC/CCND3/DDIT4/INSR/PPP2R5A/ITGB4/TNXB/RELA/MAGI1/IFNAR1/LAMA4/NOS3/CREB5/CREB1/PDGFD/SOS1/SGK3/RELN/IKBKB/ITGA1/LAMB2	3.5758623357056
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/571	140/9376	2.22847135351514	SPP1/KLF2/GNAI2/PLCB4/MEF2A/PLCB1/GNG11/SPHK1/AKT3/ADCY4/MRAS/SERPINE1/ITPR1/PRKAG2/BECN1/NOS3/SLC8A1/MEF2C/PLAT	3.72928952743621
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/571	90/9376	2.55427125899981	SESN3/PIK3R3/SOD2/AKT3/ADCY4/RB1CC1/FOXO1/INSR/RELA/PRKAG2/CREB5/CREB1/CAMKK2/CAT	3.77287783875955
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/571	71/9376	2.7752645470018	PIK3R3/AKT3/SOCS2/SOCS3/SOCS5/STAT3/IRF1/RELA/SOS1/SHC1/SOCS4/STAT5A	3.82360550194833
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/571	214/9376	1.91826112575086	HLA-B/HLA-A/B2M/HLA-E/HLA-C/HLA-F/PIK3R3/GNAI2/GNG11/NFKBIA/AKT3/TAPBP/TNFRSF1A/ITPR1/BST2/TAP1/NFATC1/GNA11/RELA/CD4/AP1S2/JUN/FBXW11/PLCG2/IKBKB	3.46032550754109
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	27/571	238/9376	1.8628088713594	PIK3R3/ANGPT2/PLA1A/RALGAPA2/ABL2/GNG11/VEGFC/RAPGEF5/AKT3/ETS1/MRAS/ETS2/RALGDS/RASA4/RAP1A/INSR/RELA/ABL1/PDGFD/SOS1/SHC1/RGL2/PLCG2/RASAL2/IKBKB/REL/RASSF1	3.43333764741047
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/571	168/9376	2.05253940455342	LEPR/PIK3R3/CSH2/CSH1/IL3RA/AKT3/SOCS2/OSMR/FHL1/SOCS3/CDKN1A/SOCS5/STAT3/IL13RA1/CCND3/IFNAR1/CREBBP/SOS1/PIAS1/SOCS4/STAT5A	3.50549507651903
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/571	169/9376	2.04039420097618	PIK3R3/CTSD/GABARAPL2/OPTN/HIF1A/AKT3/CTSB/MRAS/ITPR1/VMP1/UVRAG/STX7/RRAGB/RB1CC1/DAPK1/CFLAR/DDIT4/SQSTM1/BECN1/CAMKK2/SH3GLB1	3.4755313935601
Organismal Systems	Immune system	hsa04611	Platelet activation	17/571	126/9376	2.21543935729575	VWF/PIK3R3/GNAI2/PLCB4/PLCB1/AKT3/ADCY4/MYL12A/MYL12B/ITPR1/F2RL3/ORAI1/RAP1A/ARHGEF12/NOS3/PLCG2/FYN	3.49773347577065
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/571	163/9376	2.0147626056966	PIK3R3/TGFBR2/NFKBIA/AKT3/CDKN1A/STAT3/HSPG2/NFATC1/RELA/JUN/IFNAR1/DDB2/CREBBP/CREB5/CREB1/SOS1/STAT5A/IRF7/IFIH1/IKBKB	3.32810280948861
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/571	98/9376	2.34575931948962	PDE2A/PLCB4/PLCB1/ADCY4/CAMK1D/ITPR1/NR4A2/ATP2B1/ORAI1/PRKD2/GNA11/CREB5/CREB1/CAMK1	3.41029746293626
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/571	212/9376	1.85890361167102	THBS1/PIK3R3/GNAI2/ANGPT2/PLCB4/PLCB1/VEGFC/RAPGEF5/AKT3/ADCY4/MRAS/ID1/RAPGEF4/ARAP3/RALGDS/EVL/F2RL3/RAP1A/ITGB2/INSR/PRKD2/MAGI1/PDGFD/ITGAM	3.22113429195694
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/571	68/9376	2.65622746471618	PIK3R3/LEF1/DUSP6/AKT3/STAT3/RELA/SOS1/ITGAM/CD14/STAT5A/IKBKB	3.49048087972701
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/571	78/9376	2.52620234406574	LY96/C1QB/GNAI2/C1QA/CASP1/C1QC/IRF1/ITGB2/RELA/JUN/ITGAM/CD14	3.44670138630555
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	27/571	250/9376	1.77339404553415	OSBPL1A/HYAL2/CTSS/CTSD/NCOA7/GNS/CTSB/LAPTM5/CD68/CTSZ/PSAP/CTSH/LIPA/RRAGB/IDS/OSTM1/TPP1/CTBS/CTSF/VPS13C/AP1S2/CTSO/NPC1/ARL8A/CLN8/BLOC1S6/HEXB	3.15623701209865
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/571	110/9376	2.23913389587645	PIK3R3/ANGPT2/HIF1A/AKT3/SERPINE1/TIMP1/CDKN1A/STAT3/EGLN2/INSR/EDN1/RELA/NOS3/CREBBP/PLCG2	3.32895131573567
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/571	70/9376	2.58033525143858	LEPR/NFKBIA/AKT3/SOCS3/TNFRSF1A/STAT3/CPT1A/RELA/PRKAG2/CAMKK2/IKBKB	3.37952556274283
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/571	205/9376	1.84227927042843	HLA-B/HLA-A/HLA-E/HLA-C/HLA-F/PIK3R3/SP100/GSN/NFKBIA/RBL2/CDKN1A/YWHAH/STAT3/CCND3/HDAC7/RELA/JUN/CREBBP/CREB5/CREB1/STAT5A/IRF7/REL	3.10501504080473
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/571	193/9376	1.8717457782456	PIK3R3/GNAI2/PLCB4/PLCB1/GNG11/NFKBIA/AKT3/ADCY4/ELMO1/CCL23/STAT3/CCL21/CXCL16/RAP1A/FGR/RELA/CCL2/SOS1/SHC1/CCL14/PLCG2/IKBKB	3.11612755959612
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	13/571	91/9376	2.34575931948962	PIK3R3/IFITM1/NFKBIA/AKT3/CD81/BCL10/NFATC1/RELA/JUN/SOS1/PLCG2/CD79B/IKBKB	3.28500587283799
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/571	136/9376	2.05253940455342	PIK3R3/HSPA1A/MSN/NFKBIA/AKT3/STAT3/OAS1/OAS2/CCND3/MX1/RELA/JUN/IFNAR1/STAT5A/IRF7/IFIH1/IKBKB	3.14855181297622
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/571	34/9376	3.38065313691151	NR1D2/RORA/PER3/BHLHE40/PRKAG2/FBXW11/CREB1	3.54123430063055
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/571	93/9376	2.29531288251135	PTPRB/TGFBR2/ARHGAP29/LEF1/MYL12A/MYL12B/SMURF2/RAP1A/RASIP1/HEG1/INSR/CREBBP/FYN	3.19676709318146
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/571	93/9376	2.29531288251135	ITGA6/PIK3R3/GADD45B/LAMA5/NFKBIA/AKT3/CDKN1A/POLK/RELA/LAMA4/DDB2/IKBKB/LAMB2	3.19676709318146
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/571	149/9376	1.98366224332679	PIK3R3/PLCB4/PLCB1/SPHK1/AKT3/ADCY4/MRAS/RAPGEF4/RALGDS/CYTH1/INSR/PIP5K1C/AVPR2/PDGFD/SOS1/SHC1/PLCG2/FYN	3.08210824963974
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/571	73/9376	2.47429407672192	PIK3R3/GADD45B/AKT3/CDKN1A/STAT3/POLK/DDB2/SOS1/PLCG2/STAT5A/RASSF1	3.22012738601875
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/571	105/9376	2.18937536485698	LY96/GADD45B/ICAM1/NFKBIA/TNFRSF1A/CCL21/BCL10/CARD10/CFLAR/RELA/PLCG2/RELB/CD14/IKBKB	3.12096795873205
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/571	75/9376	2.40831290134267	SESN3/THBS1/GADD45B/SERPINE1/CDKN1A/TNFRSF10B/CCND3/DDB2/TNFRSF10A/CD82/ZMAT3	3.11820008818953
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/571	76/9376	2.37662457369343	PIK3R3/GADD45B/AKT3/CAMK1D/CDKN1A/POLK/DDB2/SOS1/SHC1/PLCG2/CAMK1	3.06845565845604
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/571	120/9376	2.05253940455342	PIK3R3/SH2B3/NFKBIA/AKT3/RPS6KA2/RAP1A/RPS6KA3/RELA/MAP3K3/JUN/ABL1/SOS1/SHC1/PLCG2/IKBKB	2.95499211239912
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/571	37/9376	3.10654612581057	PLCB4/APOL1/PLCB1/ICAM1/IDO1/LAMA4/SELE	3.26934430234582
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/571	144/9376	1.93850943763378	LY96/C1QB/C1QA/LEF1/NFKBIA/AKT3/TNFRSF1A/NOX4/C1QC/CPT1A/FOXO1/RELA/PRKAG2/LPIN2/CAMKK2/CD14/IKBKB	2.8900875860967
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/571	77/9376	2.34575931948962	PIK3R3/TGFBR2/GADD45B/AKT3/CDKN1A/STAT3/RALGDS/POLK/RELA/DDB2/IKBKB	3.01949035653559
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/571	110/9376	2.08985830281802	SMAD1/THBS1/SKIL/TGFBR2/ID1/SMURF2/BMPR2/ID2/SMAD9/SMAD7/CREBBP/SKI/INHBB/NBL1	2.92792025398137
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/571	157/9376	1.88258391245664	C1QB/THBS1/GAS6/C1QA/CASP1/HIF1A/SPHK1/TMEM30A/ELMO1/NR1H2/C1QC/CPT1A/LIPA/ATP11B/SCARF1/NFATC1/S1PR1/CREB1	2.83989928154277
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	18/571	157/9376	1.88258391245664	SMAD1/WWTR1/TGFBR2/LEF1/SERPINE1/ID1/SAV1/YWHAH/FZD4/BMPR2/ID2/CCND3/ITGB2/FBXW11/SMAD7/LATS2/FRMD6/RASSF1	2.83989928154277
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/571	69/9376	2.37975583136628	GNAI2/PLCB4/PLCB1/AQP1/CTSB/ITPR1/ORAI1/EDN1/PDE3A/CREB1	2.9292803534668
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	29/571	300/9376	1.58729713952131	ANGPT2/TGFBR2/HSPA1A/GADD45B/DUSP6/VEGFC/DUSP1/AKT3/MRAS/ELK4/TNFRSF1A/RPS6KA2/CDC25B/RAP1A/RPS6KA3/INSR/NFATC1/MAP3K11/RELA/HSPB1/MAP3K3/JUN/PDGFD/SOS1/PTPN7/RELB/CD14/MEF2C/IKBKB	2.63275400141007
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/571	70/9376	2.34575931948962	PIK3R3/HIF1A/AKT3/ETS1/CDKN1A/EGLN2/RAP1A/JUN/CREBBP/SOS1	2.87788810467557
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/571	115/9376	1.99899489834767	GNAI2/PLCB4/MEF2A/PLCB1/PDE4B/ADCY4/CDKN1A/ITPR1/NR4A2/GNA11/CREB5/CREB1/MEF2C/WNK1	2.74487303381633
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	8/571	50/9376	2.62725043782837	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/HLA-DMB/HLA-DQA2/HLA-DQA1	2.93785735942319
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/571	139/9376	1.8901082286535	PIK3R3/GNAI2/CTSD/PLCB4/PLCB1/HSPA1A/AKT3/ADCY4/ITPR1/JUN/NOS3/GABBR1/CREB5/CREB1/SOS1/SHC1	2.69230189201354
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/571	105/9376	2.03299141022433	GABARAPL2/OPTN/PINK1/HIF1A/TBC1D15/MRAS/SMURF2/AMFR/SQSTM1/RELA/JUN/BECN1/MON1B	2.71061028184594
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/571	62/9376	2.38359414722332	PIK3R3/HSPA1A/SOD2/AKT3/ADCY4/FOXO1/INSR/PRKAG2/CAT	2.78339893255071
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/571	166/9376	1.78051610997405	PDE2A/GNAI2/PLCB4/MEF2A/PLCB1/AKT3/ADCY4/ITPR1/ATP2B1/INSR/NFATC1/GNA11/PDE3A/NOS3/CREB5/SLC8A1/CREB1/MEF2C	2.58371800992111
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/571	95/9376	2.07414508249608	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/ICAM1/HLA-DMB/HLA-DQA2/HLA-DQA1/ITGB2/JUN/CCL2	2.67957781225117
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	17/571	155/9376	1.80093780012429	GNAI2/AHR/PLCB4/PLCB1/LEF1/ADCY4/CDKN1A/FZD4/ITPR1/ORAI1/KMT2A/RAP1A/PDE8A/CDKN2C/GNA11/CREB5/CREB1	2.56044022158555
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/571	144/9376	1.82447947071415	SMAD1/PIK3R3/SKIL/AKT3/PCGF5/ID1/FZD4/BMPR2/STAT3/ID2/BMI1/SMAD9/ZFHX3/PCGF2/KLF4/INHBB	2.53893864861947
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/571	87/9376	2.07613181150231	PIK3R3/TGFBR2/GADD45B/LEF1/AKT3/CDKN1A/RALGDS/POLK/JUN/DDB2/SOS1	2.56790898455666
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/571	65/9376	2.27358210965917	PLCB4/PLCB1/ADCY4/ITPR1/ORAI1/PDE8A/GNA11/CREB5/CREB1	2.62376223609191
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/571	65/9376	2.27358210965917	SPP1/PIK3R3/PLCB4/PLCB1/AKT3/ITPR1/GNA11/KCNN3/GABBR1	2.62376223609191
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/571	184/9376	1.69557602984847	PIK3R3/GNAI2/SEMA3F/MYL12A/PLXNA2/MYL12B/NTN4/BMPR2/DPYSL2/SSH1/SEMA6B/EPHA4/ARHGEF12/ABL1/PLCG2/ABLIM3/SEMA3A/FYN/EPHB4	2.42654038260076
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/571	56/9376	2.34575931948962	HSPA1A/CASP1/NFKBIA/NAIP/ITGB2/RELA/ITGAM/CD14	2.57212733900505
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	20/571	200/9376	1.64203152364273	TNFSF10/CASP1/NFKBIA/CLDN5/TUBA1A/TNFRSF1A/MYO5C/CLDN15/MYO5A/TNFRSF10B/CYTH1/NAIP/RELA/JUN/ARHGEF12/CASP4/ABL1/TNFRSF10A/IKBKB/FYN	2.33713425012035
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	14/571	125/9376	1.83907530647986	PIK3R3/GNAI2/CTSD/PLCB4/PLCB1/SPHK1/AKT3/TNFRSF1A/PPP2R5A/CERS2/RELA/S1PR1/NOS3/FYN	2.40491991332404
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/571	90/9376	2.00692741778556	PIK3R3/HIF1A/NFKBIA/AKT3/STAT3/NFATC1/RELA/MAP3K3/CD4/JUN/IKBKB	2.44424138824212
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	22/571	227/9376	1.59139619031454	AKR1C3/PIK3R3/GSTT1/MGST2/AHR/ABL2/HIF1A/SOD2/NFKBIA/AKT3/NFE2L2/NQO1/NOX4/COX7A1/PRKD2/RELA/JUN/EPHX1/ABL1/SOS1/CAT/IKBKB	2.29690825984333
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/571	138/9376	1.78481687352471	PIK3R3/CASP1/NFKBIA/AKT3/ELMO1/RPS6KA2/RPS6KA3/NFATC1/PIP5K1C/RELA/CD4/JUN/ARHGEF12/CCL2/IKBKB	2.36514574613338
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/571	103/9376	1.91304643531192	PIK3R3/PLCB4/PLCB1/LAMA5/ITGB2/GNA11/RELA/HSPB1/LAMA4/ITGAM/CD14/LAMB2	2.37268650352644
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/571	116/9376	1.84020774201341	PIK3R3/GNAI2/ICAM1/MSN/CLDN5/MYL12A/MYL12B/RAPGEF4/CLDN15/RAP1A/ITGB2/ITGAM/PLCG2	2.31872472191601
NA	NA	hsa03272	Virion - Hepatitis viruses	7/571	48/9376	2.39462930531232	CLDN5/CD9/CLDN15/CD81/HSPG2/TGOLN2/IST1	2.46674438861269
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/571	19/9376	3.4569084708268	HYAL2/GNS/IDS/HEXB	2.72983548960127
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/571	59/9376	2.22648342188845	PIK3R3/GADD45B/LEF1/AKT3/CDKN1A/POLK/DDB2/SOS1	2.40651544080928
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/571	83/9376	1.9783512333045	PCGF5/BMI1/PHC2/UBE2D1/CREBBP/ASXL2/EZH1/CBX6/PCGF2/SCML1	2.27979022177372
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/571	29/9376	2.83108883386678	WWTR1/SAV1/LATS2/FRMD6/RASSF1	2.51484546990033
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	17/571	170/9376	1.64203152364273	PIK3R3/GSTT1/MGST2/TGFBR2/GADD45B/LEF1/AKT3/NFE2L2/CDKN1A/FZD4/NQO1/POLK/PHF10/DDB2/SOS1/SHC1/PLCG2	2.15121758805888
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/571	86/9376	1.90933898097992	PIK3R3/ABL2/AKT3/CDKN1A/JUN/ABL1/SOS1/SHC1/PLCG2/STAT5A	2.15727837157825
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/571	138/9376	1.6658290819564	PIK3R3/AKT3/SOCS2/SOCS3/FBP1/FOXO1/INSR/PRKAG2/SOS1/SHC1/SOCS4/FLOT1/PRKAR1A/IKBKB	2.00656086020235
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	21/571	232/9376	1.48632163778006	TMSB4X/ITGA6/RGCC/PIK3R3/MSN/GSN/AKT3/MYL12A/MRAS/MYL12B/SPATA13/SSH1/ITGB2/ITGB4/PIP5K1C/ARHGEF12/PDGFD/SOS1/ITGAM/ITGA1/DIAPH2	1.91002252471031
NA	NA	hsa04081	Hormone signaling	20/571	219/9376	1.49957216771026	RAMP3/LEPR/SMAD1/PIK3R3/GNAI2/PLCB4/PLCB1/CSH2/GNG11/CSH1/RAMP2/ADCY4/RAPGEF4/STAT3/HEPH/SMAD9/INSR/GNA11/AVPR2/STAT5A	1.90494612379675
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/571	233/9376	1.47994257495697	ITGA6/THBS1/VIM/PDLIM1/SNTB2/SYNE1/PDLIM4/SPTBN1/FHL1/HSPG2/SUN2/LMNA/PLEC/TMEM43/ITGB4/CAPZA2/AGRN/SYNE2/ITGA1/ELN/DIAPH2	1.8891301966712
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/571	115/9376	1.71342419858372	PIK3R3/GNAI2/PLCB4/PLCB1/GNG11/AKT3/ADCY4/ITPR1/GNA11/CREB5/CREB1/FYN	1.96022907384554
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/571	91/9376	1.80443024576124	PDE2A/GNAI2/GNG11/PDE4B/ADCY4/PDE7B/PDE8A/PDE3A/GABBR1/GABRE	1.9636186377044
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	20/571	226/9376	1.45312524216171	PIK3R3/GNAI2/PDE4B/NFKBIA/AKT3/ADCY4/RAPGEF4/ARAP3/ATP2B1/ORAI1/RAP1A/NFATC1/EDN1/RELA/JUN/PDE3A/GABBR1/CREBBP/CREB5/CREB1	1.75590469765839
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/571	107/9376	1.68806979066075	PLCB4/PLCB1/AKT3/ITPR1/CPT1A/FBP1/FOXO1/PRKAG2/CREBBP/CREB5/CREB1	1.82283328716201
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/571	47/9376	2.09621045571413	PIK3R3/SOCS2/SOCS3/INSR/SOCS4/IKBKB	1.91851118139753
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/571	109/9376	1.65709603303395	SPP1/LY96/PIK3R3/NFKBIA/AKT3/RELA/JUN/IFNAR1/CD14/IRF7/IKBKB	1.75716087603695
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/571	122/9376	1.61511297407482	LEPR/PIK3R3/AKT3/CPT1A/FBP1/FOXO1/INSR/PPP2R5A/PRKAG2/CREB5/CREB1/CAMKK2	1.74144221141998
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	12/571	122/9376	1.61511297407482	PIK3R3/NFKBIA/AKT3/BCL10/PPP2R5A/NFATC1/RELA/CD4/JUN/SOS1/IKBKB/FYN	1.74144221141998
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/571	217/9376	1.43772345388073	PIK3R3/GNAI2/GSTT1/MGST2/AHR/AKT3/ADCY4/RPS6KA2/STAT3/CCND3/RPS6KA3/RELA/JUN/EPHX1/CREB5/CREB1/SOS1/KLF4/STAT5A	1.66128700136558
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/571	37/9376	2.21896151843612	GADD45B/LEF1/CDKN1A/POLK/DDB2	1.89181943193601
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/571	98/9376	1.67554237106401	PIK3R3/GSN/SPHK1/AKT3/FCGR3A/ASAP1/PIP5K1C/MARCKSL1/PLCG2/ASAP2	1.7118963255772
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/571	50/9376	1.97043782837128	THBS1/ICAM1/CD81/ITGB2/CCL2/SELE	1.75204003616554
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/571	100/9376	1.64203152364273	TNFSF10/ACKR3/TNFRSF14/TNFRSF1A/CCL23/CCL21/TNFRSF10B/CCL2/CCL14/TNFRSF10A	1.64367138525287
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	21/571	250/9376	1.3793064798599	HLA-B/HLA-A/HLA-E/HLA-C/HLA-F/TGFBR2/HSPA1A/EHD4/EHD2/SMURF2/ARAP3/ARAP2/CYTH1/ASAP1/WWP1/RAB11FIP5/CAPZA2/PIP5K1C/ASAP2/IST1/SH3GLB1	1.54795754838765
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/571	154/9376	1.4927559305843	GNAI2/PLCB4/PLCB1/ADCY4/CAMK1D/CDKN1A/ITPR1/NFATC1/PRKAG2/JUN/NOS3/CAMKK2/MEF2C/CAMK1	1.57006876422416
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/571	168/9376	1.46609957468101	FTL/TNFSF10/CASP1/MLKL/IL33/TNFRSF1A/STAT3/GLUL/TNFRSF10B/CFLAR/SQSTM1/IFNAR1/TNFRSF10A/CAPN2/STAT5A	1.552350208594
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/571	89/9376	1.66048131604321	GNAI2/PLCB4/PLCB1/ADCY4/TUBA1A/ITPR1/GNA11/PDGFD/SOS1	1.59425148190657
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/571	18/9376	2.73671920607122	TCN2/CD320/ABCD4	1.87807681531415
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/571	254/9376	1.35758511797234	PLCB4/PLCB1/VEGFC/SPHK1/ADCY4/CAMK1D/STIM2/HRH1/ITPR1/ATP2B1/ORAI1/NFATC1/GNA11/NOS3/SLC8A1/PDGFD/PTAFR/PLCD3/PLCG2/ASPH/CAMK1	1.47126286187973
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	24/571	298/9376	1.32244149555119	LEPR/TNFSF10/ACKR3/TGFBR2/TNFRSF14/CSH2/CSH1/IL3RA/IL33/OSMR/TNFRSF1A/BMPR2/ACVRL1/CCL23/CCL21/TNFRSF10B/IL13RA1/CXCL16/CD4/IFNAR1/CCL2/CCL14/TNFRSF10A/INHBB	1.44046590036569
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	14/571	158/9376	1.45496464120242	GADD45B/RBL2/CDKN1A/YWHAH/CDC25B/CCND3/ANAPC16/CCNH/CDKN2C/PPP2R5A/CREBBP/ABL1/ATRX/NIPBL	1.46867887904713
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/571	158/9376	1.45496464120242	PIK3R3/AKT3/FZD4/TNFRSF1A/RPS6KA2/RRAGB/RPS6KA3/DDIT4/INSR/LPIN2/SOS1/GRB10/IKBKB/PRR5	1.46867887904713
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/571	67/9376	1.71555532320882	PLCB4/PLCB1/RPS6KA2/ITPR1/RAP1A/RPS6KA3/CREBBP	1.49681496061094
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/571	80/9376	1.64203152364273	PIK3R3/GAS6/AKT3/STAT3/PDGFD/SOS1/SHC1/PLCG2	1.46856204788278
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/571	55/9376	1.79130711670116	UGCG/SPHK1/PSAP/CERS2/ACER3/HEXB	1.49876718069469
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	17/571	204/9376	1.36835960303561	HOXD10/THBS1/PIK3R3/DDX5/TIMP3/MSN/HIF1A/AKT3/MRAS/CDKN1A/FZD4/STAT3/ITPR1/HSPG2/ARHGEF12/SOS1/PLCG2	1.35454696998388
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/571	122/9376	1.48052022623525	PIK3R3/PLCB4/PLCB1/HIF1A/AKT3/FOXO1/CREBBP/MED17/PLCD3/PLCG2/NOTCH4	1.36039758658279
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/571	44/9376	1.86594491323038	DYNC1LI2/CREB5/AVPR2/CREB1/STX4	1.46611572133428
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/571	323/9376	1.27092223192162	HOXD10/THBS1/PIK3R3/VIM/ABCB1/TIMP3/FOXP1/SOX4/CDKN1A/BMPR2/TNC/STAT3/BMI1/CDC25B/SLC7A1/DDIT4/TNXB/CREBBP/ABL1/SOS1/SHC1/PLCG2/IKBKB/NOTCH4/RASSF1	1.26179458100578
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/571	83/9376	1.5826809866436	IFI16/CASP1/MLKL/NFKBIA/IL33/RELA/IRF7/IKBKB	1.35778478172582
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	19/571	238/9376	1.31086550206773	VWF/C1QB/PIK3R3/C1QA/CASP1/NFKBIA/TNFRSF1A/STAT3/C1QC/OAS1/OAS2/MX1/RELA/JUN/IFNAR1/CCL2/PLCG2/IFIH1/IKBKB	1.23701351128748
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/571	98/9376	1.50798813395761	PIK3R3/PLCB4/PLCB1/ITPR1/PIP5K1C/INPP1/PLCD3/PIK3C2A/PLCG2	1.28729604123743
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/571	99/9376	1.4927559305843	PIK3R3/AKT3/ADCY4/CDKN1A/CDKN2C/JUN/SOS1/SHC1/NOTCH4	1.25511838484305
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/571	99/9376	1.4927559305843	PIK3R3/HIF1A/AKT3/RALGDS/PIP5K1C/JUN/PDGFD/SOS1/SLC44A4	1.25511838484305
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/571	86/9376	1.52747118478394	PLCB4/PLCB1/ADCY4/RAPGEF4/GNA11/KCNN3/CREB5/CREB1	1.25135092893402
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/571	73/9376	1.57455077609577	PIK3R3/GADD45B/AKT3/CDKN1A/POLK/DDB2/PDGFD	1.25492377536919
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/571	128/9376	1.41112084063047	PDE2A/ENTPD1/PDE4B/ADCY4/GUK1/PDE7B/AK3/PDE8A/PDE9A/PDE3A/NME3	1.19258564954411
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/571	60/9376	1.64203152364273	PIK3R3/SPHK1/AKT3/HSPB1/NOS3/PLCG2	1.27044611588688
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	13/571	157/9376	1.35964393677424	LEPR/PIK3R3/AKT3/SOCS3/TNFRSF1A/COX7A1/INSR/MAP3K11/RELA/PRKAG2/JUN/MLXIP/IKBKB	1.15722997353699
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/571	101/9376	1.46319640720639	GNAI2/PLCB4/PLCB1/LEF1/ADCY4/FZD4/EDN1/CREBBP/CREB1	1.19181246142812
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/571	143/9376	1.37792855130859	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DMA/HLA-DPB1/C1QB/C1QA/HLA-DMB/FCGR3A/HLA-DQA2/C1QC/HLA-DQA1	1.15969908860892
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/571	61/9376	1.61511297407482	FTL/MT1M/HEPH/ATP2B1/SLC8A1/SLC30A1	1.22734706217037
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/571	49/9376	1.67554237106401	GNAI2/RELA/JUN/CREB5/CREB1	1.20730961020921
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/571	63/9376	1.56383954632641	GADD45B/LEF1/CDKN1A/FZD4/POLK/DDB2	1.14345747625282
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/571	148/9376	1.33137691106167	PIK3R3/GADD45B/LEF1/AKT3/CDKN1A/FZD4/POLK/JUN/DDB2/SOS1/SHC1/NOTCH4	1.03475687909017
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/571	134/9376	1.34793632537836	RAMP3/PLCB4/PLCB1/CALCRL/RAMP2/ADCY4/PRKCH/ITPR1/EDN1/GNA11/ARHGEF12	1.03301874385697
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/571	78/9376	1.47361803403835	PLCB4/PLCB1/PIP5K1C/INPP1/PLCD3/PIK3C2A/PLCG2	1.06959600792552
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/571	150/9376	1.31362521891419	PIK3R3/ABCB1/TGFBR2/GADD45B/LEF1/AKT3/CDKN1A/FZD4/POLK/DDB2/SOS1/SHC1	0.986027197082597
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/571	93/9376	1.4125002353916	PLCB4/PLCB1/ADCY4/ITPR1/GNA11/MAP3K3/JUN/SOS1	1.01802984918427
NA	NA	hsa04517	IgSF CAM signaling	22/571	299/9376	1.20818372977057	APP/PIK3R3/EPB41L3/ICAM1/MSN/ROBO4/AKT3/MYL12A/PLXNA2/SPTBN1/MYL12B/TUBA1A/RAP1A/ITGB2/FOXO1/MAGI1/ABL1/ITGAM/PLCG2/PMP22/FYN/MBP	0.931644498206157
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/571	52/9376	1.57887646504109	APOE/APOC1/LIPA/CYP27A1/NPC1	1.06592204617325
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/571	26/9376	1.89465175804931	FOLH1/TCN2/ABCD4	1.16325224778746
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/571	154/9376	1.27950508335797	GNAI2/PLCB4/PLCB1/AKT3/ADCY4/RAPGEF4/ATP2B1/PPP2R5A/CREB5/SLC8A1/SCN1B/CREB1	0.890587354883482
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/571	170/9376	1.25567116513856	YBX3/MSN/SYNPO/CLDN5/MYL12A/MYL12B/TUBA1A/CLDN15/RAP1A/RAB13/PRKAG2/JUN/MAGI1	0.856662464305468
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/571	97/9376	1.35425280300432	GNAI2/PLCB4/PLCB1/GNG11/ADCY4/PER3/ITPR1/CREB1	0.893074290441593
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/571	41/9376	1.60198197428559	THBS1/CDKN1A/DAPK1/RASSF1	0.983687757379813
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/571	16/9376	2.05253940455342	A4GALT/HEXB	1.07299931048706
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/571	99/9376	1.32689416051938	PIK3R3/PLCB4/PLCB1/ADCY4/HRH1/PRKCH/ITPR1/PLCG2	0.832645221091895
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/571	99/9376	1.32689416051938	ITGA6/SNTB2/LMNA/ITGB4/EDN1/PRKAG2/SLC8A1/ITGA1	0.832645221091895
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/571	86/9376	1.33653728668594	ITGA6/SNTB2/LEF1/LMNA/ITGB4/SLC8A1/ITGA1	0.798387207611909
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/571	72/9376	1.36835960303561	NFKBIA/ZNFX1/RELA/IRF7/IFIH1/IKBKB	0.798991953810003
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/571	17/9376	1.93180179252086	GLUL/CA5B	0.979201997641404
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/571	73/9376	1.34961495093923	MDFIC/BST2/SERINC3/MX1/CD4/CREBBP	0.763622872706804
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/571	59/9376	1.39155213868028	PIK3R3/GNAI2/AKT3/ADCY4/INSR	0.768274768985582
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/571	45/9376	1.45958357657132	ABCG1/ABCB1/ABCD4/TAP1	0.786947345787216
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/571	89/9376	1.29148546803361	GNAI2/GABARAPL2/GNG11/ADCY4/GLUL/GABBR1/GABRE	0.703579538253599
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/571	195/9376	1.17889442723068	VWF/PIK3R3/PLCB4/PLCB1/CASP1/AKT3/FCGR3A/ITGB2/HDAC7/FPR3/RELA/CASP4/ITGAM/PLCG2	0.64284776179278
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/571	60/9376	1.36835960303561	GNAI2/PLCB4/PLCB1/ITPR1/GNA11	0.7289066185894
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/571	75/9376	1.31362521891419	PIK3R3/GSTT1/MGST2/AKT3/CDKN1A/REV3L	0.694409732627108
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/571	75/9376	1.31362521891419	PLCB4/PLCB1/ADCY4/ITPR1/CREB5/CREB1	0.694409732627108
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/571	33/9376	1.4927559305843	STX7/STX11/STX4	0.722078921709124
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/571	48/9376	1.36835960303561	PIK3R3/PLCB4/PLCB1/AKT3	0.651534411559065
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/571	93/9376	1.23593770596765	PLCB4/PLCB1/CST3/LYZ/ADCY4/ITPR1/ATP2B1	0.58228240038483
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/571	63/9376	1.30319962193868	KMT2E/KMT2B/ASH1L/KMT2A/EZH1	0.614883927105927
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/571	110/9376	1.19420474446744	PIK3R3/GNAI2/AKT3/ADCY4/RPS6KA2/CDC25B/ANAPC16/RPS6KA3	0.521733883455528
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/571	142/9376	1.15636022791742	SOCS3/SMURF2/UBE2L6/ANAPC16/WWP1/UBE2D1/DDB2/FBXW11/PIAS1/UBE2B	0.478095376788775
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/571	21/9376	1.56383954632641	DSE/CHST12	0.658691860057354
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/571	144/9376	1.14029966919634	PIK3R3/PLCB4/PLCB1/AKT3/RORA/ITPR1/ATXN3/RB1CC1/BECN1/RELN	0.43204502375611
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/571	37/9376	1.33137691106167	FOLH1/GLUL/ASRGL1	0.51429456152619
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/571	83/9376	1.1870107399827	SOD2/ABCD4/FAR1/DHRS4/CAT/PEX2	0.435779341677928
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/571	53/9376	1.23926907444734	PLCB4/PLCB1/ATP2B1/SLC8A1	0.444821401905106
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/571	38/9376	1.29634067656005	NNMT/NAMPT/SIRT2	0.466117215876469
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/571	38/9376	1.29634067656005	ORAI1/TAP1/CD4	0.466117215876469
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/571	69/9376	1.18987791568314	PIK3R3/AKT3/SOS1/PLCG2/FYN	0.403118896346372
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/571	23/9376	1.42785349881977	GLUL/NOS3	0.523145568525805
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/571	85/9376	1.15908107551252	ENTPD1/GUK1/AK3/CDA/NME3/CMPK2	0.375176617408886
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/571	133/9376	1.11114915133719	GNAI2/PLCB4/PLCB1/GNG11/AKT3/ITPR1/PPP2R5A/CREB5/CREB1	0.328749050524283
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/571	24/9376	1.36835960303561	EXT1/GLCE	0.460112868909182
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/571	71/9376	1.15636022791742	NFKBIA/RELA/JUN/PLCG2/IKBKB	0.336772245444005
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/571	105/9376	1.09468768242849	ITGA6/SNTB2/ADCY4/LMNA/ITGB4/SLC8A1/ITGA1	0.248464220529272
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/571	138/9376	1.07089012411483	ADCY4/YWHAH/RPS6KA2/ITPR1/ANAPC16/RPS6KA3/SLK/PPP2R5A/FBXW11	0.213636430547218
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/571	42/9376	1.17287965974481	AOC1/IDO1/CAT	0.285939173950965
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/571	26/9376	1.26310117203287	HHEX/NR5A2	0.342091799417093
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/571	59/9376	1.11324171094423	ENTPD1/CDA/NME3/CMPK2	0.222194545044348
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/571	76/9376	1.08028389713338	GNAI2/PLCB4/PLCB1/ADCY4/ITPR1	0.178950443824252
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/571	94/9376	1.04810522785706	NFKBIA/RELA/JUN/CCL2/TRAF3IP2/IKBKB	0.119364293817358
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/571	28/9376	1.17287965974481	A4GALT/B3GNT5	0.233293465837116
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/571	28/9376	1.17287965974481	AKR1C3/SPR	0.233293465837116
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/571	194/9376	1.01568960225324	MYL12A/MYL12B/TUBA1A/MYO5C/MYO5A/CAPZA2/KIF13B/DYNC1LI2/KIF9/KIFC3/KLC1/DYNLT3	0.0562319529407953
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/571	62/9376	1.0593751765437	NRARP/MFNG/CREBBP/NOTCH4	0.119446011927271
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/571	12/9376	1.36835960303561	NQO1	0.325140394968577
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/571	12/9376	1.36835960303561	NPC1	0.325140394968577
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/571	46/9376	1.07089012411483	PSMB9/PSMB8/PSMB10	0.122733421903775
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/571	63/9376	1.04255969755094	AKR1C3/LTC4S/HPGD/GGT5	0.0863103779590331
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/571	30/9376	1.09468768242849	RELA/IKBKB	0.13227575165908
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/571	115/9376	0.999497449173837	APP/GNAI2/PLCB4/PLCB1/GNG11/DUSP1/ITPR1	-0.00138082608143315
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/571	116/9376	0.990881091853373	GNAI2/PLCB4/PLCB1/GNG11/ADCY4/ITPR1/GLUL	-0.0251654878896943
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/571	31/9376	1.0593751765437	FBP1/H6PD	0.0843208780291343
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/571	31/9376	1.0593751765437	GLUL/CAT	0.0843208780291343
NA	NA	hsa04981	Folate transport and metabolism	2/571	31/9376	1.0593751765437	FOLH1/SLCO2B1	0.0843208780291343
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/571	49/9376	1.00532542263841	MFNG/FUT11/GALNT10	0.0095174399196431
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/571	32/9376	1.02626970227671	GABARAPL2/BECN1	0.0379055443033364
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/571	32/9376	1.02626970227671	TNFRSF1A/BECN1	0.0379055443033364
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/571	102/9376	0.965900896260431	PLCB4/PLCB1/ADCY4/ITPR1/ATP2B1/RAP1A	-0.088175618856068
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/571	50/9376	0.985218914185639	AOC1/SAT2/NOS3	-0.0266859487209219
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/571	15/9376	1.09468768242849	HEXB	0.0934581125676702
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/571	52/9376	0.947325879024653	AKR1C3/ADCY4/INSR	-0.0969922085300765
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/571	178/9376	0.922489620024007	PLCB4/PLCB1/LEF1/FZD4/CCND3/NFATC1/JUN/FBXW11/CREBBP/PRICKLE4	-0.26586561741627
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/571	17/9376	0.965900896260431	CYP27A1	-0.0358337049440912
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/571	17/9376	0.965900896260431	GGT5	-0.0358337049440912
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/571	56/9376	0.879659744808606	SMURF2/FBXW11/SPOP	-0.230004322376172
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/571	18/9376	0.912239735357073	HEXB	-0.094903377446127
NA	NA	hsa04382	Cornified envelope formation	12/571	217/9376	0.908035865608884	ITGA6/UGCG/S100A10/S100A16/S100A6/LAMA5/CLDN5/CLDN15/PLEC/PPP2R5A/ITGB4/COL17A1	-0.349030465928441
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/571	38/9376	0.864227117706701	PIK3R3/INSR	-0.21355852534558
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/571	59/9376	0.834931283208169	GSTT1/MGST2/GGT5	-0.323885678896886
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/571	78/9376	0.842067448021914	BTG1/CNOT6L/DDX6/CNOT4	-0.356667219102498
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/571	205/9376	0.881090085857076	PIK3R3/CTSD/PLCB4/TGFBR2/PLCB1/AKT3/COX7A1/INSR/PDK4/RELA/NOS3	-0.438354694075249
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/571	20/9376	0.821015761821366	LIPA	-0.204043935306037
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/571	20/9376	0.821015761821366	CYB5R3	-0.204043935306037
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/571	42/9376	0.781919773163206	FTL/SAT2	-0.360699922760141
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/571	82/9376	0.800990987142796	GSTT1/MGST2/CDA/NME3	-0.460911293711168
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	21/571	388/9376	0.888728401971582	APOE/APP/PIK3R3/PLCB4/PLCB1/SNCA/BACE2/AKT3/TUBA1A/FZD4/TNFRSF1A/NOX4/ITPR1/COX7A1/RB1CC1/INSR/RELA/BECN1/CAPN2/KLC1/IKBKB	-0.570043067348551
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/571	22/9376	0.746377965292151	AOC1	-0.303276425122665
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/571	44/9376	0.746377965292151	MGAT4B/HEXB	-0.429402894665472
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/571	44/9376	0.746377965292151	PARP4/NEIL1	-0.429402894665472
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/571	23/9376	0.713926749409883	AQP1	-0.349787844981571
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/571	86/9376	0.763735592391968	PLCB4/PLCB1/ADCY4/GABBR1	-0.560503956354434
NA	NA	hsa04082	Neuroactive ligand signaling	10/571	199/9376	0.825141469167202	GNAI2/PLCB4/PLCB1/GNG11/ADCY4/HRH1/GNA11/GABBR1/GABRE/OGFR	-0.634895150216284
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/571	46/9376	0.713926749409883	FTL/HEPH	-0.495284066694398
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/571	69/9376	0.713926749409883	JUN/CREB5/CREB1	-0.607345686501799
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/571	90/9376	0.729791788285659	ABCB1/AQP1/ADCY4/EPHX1	-0.655910329631858
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/571	70/9376	0.703727795846885	GSTT1/MGST2/EPHX1	-0.633574101795279
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/571	149/9376	0.771424205738196	GNAI2/PLCB4/PLCB1/GNG11/ADCY4/ITPR1/GABRE	-0.716196383404557
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/571	71/9376	0.69381613675045	PIK3R3/HIF1A/AKT3	-0.659465827842946
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/571	27/9376	0.608159823571382	HSD17B12	-0.519215056244344
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/571	51/9376	0.643933930840287	ENPP2/LPCAT2	-0.649277375882359
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/571	28/9376	0.586439829872404	HSD17B12	-0.558081185280395
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/571	28/9376	0.586439829872404	SLC12A7	-0.558081185280395
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/571	174/9376	0.754957022364474	HSPA1A/NFE2L2/HERPUD1/ATXN3/AMFR/UBE2D1/MBTPS1/CAPN2	-0.830834999110116
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/571	117/9376	0.701722873351595	BAZ2B/CDK2AP1/PHF10/TFPT/MEAF6	-0.826741715722157
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/571	54/9376	0.608159823571382	REV3L/POLK	-0.735343581681553
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/571	78/9376	0.631550586016435	PIK3R3/ELMO1/SHC1	-0.832088294778503
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/571	79/9376	0.623556274801037	GSTT1/MGST2/EPHX1	-0.855620546098806
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/571	57/9376	0.576151411804467	CPT1A/HSD17B12	-0.817339570069456
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/571	103/9376	0.637682145103973	COL18A1/SLC8A1/COL17A1/ELN	-0.941536652519507
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/571	104/9376	0.631550586016435	PLA1A/LPCAT2/LPIN2/ETNK1	-0.962158986424013
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/571	35/9376	0.469151863897923	FBP1	-0.801210523907039
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/571	36/9376	0.456119867678537	CRYL1	-0.832568583445011
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/571	36/9376	0.456119867678537	PGM2L1	-0.832568583445011
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/571	36/9376	0.456119867678537	GALNT10	-0.832568583445011
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/571	191/9376	0.687761894719469	GNAI2/GNG11/HDAC7/CREB5/CREB1/SOS1/SHC1/CAMKK2	-1.11020203325294
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/571	63/9376	0.52127984877547	CCNH/DDB2	-0.970836720334754
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/571	87/9376	0.566217766773356	COX7A1/SLC8A1/ASPH	-1.03510860113753
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/571	38/9376	0.432113558853351	HEXB	-0.893234266567629
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/571	154/9376	0.639752541678987	NQO1/IDO1/AK3/SPR/NME3/CMPK2	-1.14785687313854
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/571	370/9376	0.754446916268282	LEPR/RXFP1/NR3C1/CSH2/CALCRL/CSH1/HRH1/F2RL3/FPR3/EDN1/S1PR1/GABBR1/AVPR2/PTAFR/GABRE/CHRNB1/OGFR	-1.22721115828271
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	12/571	275/9376	0.716522846680465	C1QB/PIK3R3/C1QA/HSPA1A/TUBA1A/ITPR1/C1QC/COX7A1/CREB5/CREB1/KLC1/FYN	-1.21500723721084
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/571	66/9376	0.497585310194767	AKR1C3/HSD17B12	-1.04303400720182
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/571	41/9376	0.400495493571398	SDS	-0.979639372371083
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/571	41/9376	0.400495493571398	GABRE	-0.979639372371083
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/571	68/9376	0.482950448130215	ALDH1A1/DHRS4	-1.089676154466
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/571	116/9376	0.566217766773356	FBP1/H6PD/CAT/SDS	-1.19711059279255
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/571	43/9376	0.381867796195984	CPT1A	-1.03453211577831
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/571	44/9376	0.373188982646075	CCNH	-1.06124243333205
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	22/571	480/9376	0.752597781669585	APP/PLCB4/PLCB1/SNCA/OPTN/PINK1/HIP1/TUBA1A/FZD4/TNFRSF1A/NOX4/ITPR1/UBE2L6/ATXN3/COX7A1/RB1CC1/SQSTM1/RELA/BECN1/CAPN2/CAT/KLC1	-1.41698689322081
NA	NA	hsa04519	Cadherin signaling	18/571	404/9376	0.731598203603197	PCDH17/WWTR1/VIM/LEF1/NFKBIA/MRAS/SAV1/YWHAH/FZD4/EVL/RELA/CREBBP/SCN1B/LATS2/CDH24/GABRE/PRICKLE4/IKBKB	-1.40433422605501
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	13/571	308/9376	0.693065253485569	PLCB4/PLCB1/SOD2/HIP1/TUBA1A/ITPR1/COX7A1/RB1CC1/BECN1/CREBBP/CREB5/CREB1/KLC1	-1.39477665623434
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/571	73/9376	0.449871650313077	GSTT1/MGST2	-1.20158073794275
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/571	75/9376	0.437875072971395	GLUL/SDS	-1.24462255182283
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/571	47/9376	0.349368409285688	ACYP2	-1.13869008934302
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/571	76/9376	0.432113558853351	CPT1A/CYP27A1	-1.26580216349164
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	9/571	235/9376	0.628863136714238	ADCY4/RPS6KA2/CPT1A/COX7A1/RPS6KA3/PRKAG2/CREB5/CREB1/SOS1	-1.46727048574559
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/571	51/9376	0.321966965420144	PLCG2	-1.2363759076861
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/571	54/9376	0.304079911785691	SDS	-1.30599259855345
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/571	268/9376	0.612698329717437	GNAI2/SNCA/PINK1/DUSP1/NFE2L2/TUBA1A/ITPR1/UBE2L6/COX7A1/KLC1	-1.63811455127266
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/571	56/9376	0.293219914936202	MGAT4B	-1.35085698692866
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/571	65/9376	0.252620234406574	LPIN2	-1.53970976045513
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/571	67/9376	0.245079331886975	FBP1	-1.57916028775907
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/571	108/9376	0.304079911785691	IPO11/SUMO3	-1.85232526442921
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/571	79/9376	0.207852091600346	CPLX1	-1.80047635438129
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	12/571	368/9376	0.535445062057413	CASP1/OPTN/PINK1/TUBA1A/TNFRSF1A/COX7A1/ANXA7/RB1CC1/SQSTM1/BECN1/CAT/KLC1	-2.31518560493799
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/571	103/9376	0.159420536275993	PPP2R5A	-2.18437033603674
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/571	138/9376	0.118987791568314	COX7A1	-2.655042656901
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/571	243/9376	0.202719941190461	DDX5/HSPA1A/PRPF6	-3.2066113246014
Genetic Information Processing	Translation	hsa03010	Ribosome	1/571	222/9376	0.0739653839478708	MRPL33	-3.55579951755699
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/571	449/9376	0.0731417159751774	PDE2A/SLC8A1	-5.12534083418037