category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	142/2333	250/9376	2.28271238748393	CTSS/LAPTM5/CTSA/CD68/ATP6V0D1/CTSD/ASAH1/HEXB/LGMN/BLOC1S6/GNS/CTSB/IDS/HEXA/TPP1/SLC17A5/LAMP2/SLC15A3/CTSH/NAGLU/IGF2R/HGSNAT/RRAGC/GAA/LIPA/AGA/GNPTG/CTSZ/CLTB/VAMP8/SLC11A1/ATP6V0E1/PSAP/LAPTM4A/ATP6V1G1/LAMP1/RRAGD/AP1S2/ATP6AP1/CLCN7/GALNS/AP3S1/AP2B1/ENTPD4/NPC2/AP2A2/CTSO/ATP6V1B2/MITF/GUSB/ACP5/GLB1/VAMP7/VPS13C/MCOLN1/SCARB2/GGA1/CTSF/ATP6V0A1/ARSA/SLC29A3/DMXL2/PLA2G15/ARL8B/CLTC/LAMTOR4/CTBS/ATP6V1H/AP1B1/ATP6V1C1/NPC1/TLR7/NAGA/AP1G1/ACP2/OSTM1/ATP6V0B/FUCA1/OSBP/OSBPL2/NEU1/TPCN1/BLOC1S1/PLEKHM1/ARSG/ATP6V1A/ATP6V1E1/PPT1/AP4E1/LAMTOR3/ARL8A/SLC15A4/SPG11/SUMF1/SMPD1/DTNBP1/NAGPA/ATP6V1D/TLR8/CLN8/MANBA/GNPTAB/AP5S1/SLC11A2/VPS39/GGA3/CTSL/AP5Z1/GPR155/VPS11/TFE3/GGA2/SLC2A6/RAB7A/TMEM175/PIKFYVE/VPS35/AP5M1/DMXL1/ZFYVE26/SGSH/STX17/CTNS/FIG4/ATP6V0A2/RPTOR/MFSD8/ABCA5/WDR7/OSBPL3/SLC38A9/ATP6V1E2/TFEB/BLOC1S3/AP2S1/DEPTOR/RRAGB/ATP6V0E2/HYAL4/TLR3/MAN2B1/AP3S2	11.8310482185351
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	87/2333	142/9376	2.46225919598172	TYROBP/NFKBIA/SQSTM1/PIK3R1/TGFBR1/TREM2/TGFB2/MAPK3/ITPR2/JUN/FCGR3A/IFNGR2/IL1B/JUNB/SPI1/NCF2/FOSB/FCGR1A/LILRB4/FCGR2A/LCP2/LILRB3/SYK/JUND/FOS/SOCS1/OSCAR/SIRPA/MAPK8/BTK/MITF/ACP5/MAP2K1/IFNGR1/AKT3/STAT1/PIK3CA/TNF/CYLD/LILRB1/CSF1R/LILRB2/MAPK1/BLNK/NFKB1/TGFBR2/TNFRSF1A/NFKB2/FHL2/IL1R1/MAP3K7/PPP3R1/LILRA2/SIRPB1/IFNAR1/PIK3CD/TAB2/STAT2/MAP2K7/PPP3CB/RELA/TMEM64/IL1A/LILRA6/MAPK14/PLCG2/IKBKG/ITPR3/FCGR2B/CSF1/PPP3CC/FOSL2/IKBKB/RELB/NCF4/TRAF6/CHUK/AKT2/PPP3CA/ITPR1/PIK3R2/TNFRSF11A/FCGR3B/NFATC1/FOSL1/NCF1/PIK3R3	10.10503359631
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	96/2333	169/9376	2.28290262936971	CTSD/SQSTM1/GABARAPL2/PIK3R1/GABARAP/CTSB/MAPK3/LAMP2/DAPK1/GABARAPL1/MAP1LC3B/RRAGC/CFLAR/IRS2/RHEB/VAMP8/PPP2CB/LAMP1/MAPK8/RRAGD/PDPK1/RB1CC1/OPTN/MRAS/STX7/MAP2K1/NBR1/ATG16L2/EIF2AK4/AKT3/PIK3CA/MAPK1/RAB1A/UBC/BIRC6/RAF1/MAP3K7/PLEKHM1/ULK2/TP53INP2/PIK3CD/CAMKK2/C9orf72/UBB/ATG13/STK11/SUPT20H/HIF1A/ULK1/EPG5/GORASP2/BECN1/TSC1/WDFY3/DAPK3/VPS39/WDR45B/TSC2/BCL2L1/CTSL/ERN1/CALCOCO2/PRKACA/VPS11/RPS6KB1/ATG2B/BCL2/TBK1/PRKACB/EIF2AK3/SH3GLB1/MTMR3/RAB7A/UVRAG/ATG14/ATG7/GORASP1/PIK3C3/PRKAA1/WIPI1/TRAF6/KRAS/ATG4D/STX17/AKT2/ATG16L1/ZFYVE1/ATG9B/ITPR1/PIK3R2/RPTOR/DEPTOR/RRAGB/MAP1LC3B2/ATG2A/PIK3R3	9.68594813854903
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	74/2333	119/9376	2.49912292392311	NFKBIA/CREB5/CXCL2/PIK3R1/MAPK3/JUN/MAP2K3/CXCL3/CFLAR/IL1B/JUNB/BCL3/ICAM1/CCL20/MMP9/FOS/BIRC3/IRF1/MAPK8/CCL5/CEBPB/MAP2K1/PTGS2/XIAP/AKT3/TNFAIP3/MAP3K5/PIK3CA/TNF/CYLD/DAB2IP/MAPK1/NFKB1/CREB3L2/ATF4/CXCL10/TNFRSF1A/TRADD/MAP3K7/RPS6KA5/ATF6B/RHBDF1/TNFRSF1B/PIK3CD/TAB2/MAP2K7/RELA/ATF2/ITCH/MLKL/RIPK1/CCL2/BIRC2/MAPK14/FADD/IKBKG/RHBDF2/CSF1/CASP7/MAP2K4/TRAF1/IKBKB/TAB3/BAG4/CHUK/TRAF3/AKT2/PIK3R2/EDN1/RIPK3/CXCL1/JAG1/IL18R1/PIK3R3	9.47195786529899
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	110/2333	216/9376	2.04664158371831	ABCA1/NFKBIA/TNFSF10/CCL3/CXCL2/OLR1/PIK3R1/MAPK3/RXRA/JUN/VAV3/MAP2K3/CAMK2G/CXCL3/HSPA1B/CD36/IL1B/LY96/NCF2/VLDLR/PYCARD/ABCG1/ICAM1/CD14/CYBB/IL18/MMP9/FOS/CASP1/MAPK8/CCL5/PDPK1/PTK2/NFE2L2/CD40/BID/HSPA6/RXRB/TLR4/AKT3/HSPA1A/MAP3K5/POU2F2/PIK3CA/TNF/MAPK1/TLR2/NFKB1/VAV1/ATF4/NLRP3/TNFRSF1A/PLCB2/CAMK2D/MAP3K7/JAK2/LDLR/RAP1A/NFATC3/PPP3R1/STAT3/MIB1/PIK3CD/TNFRSF10A/TAB2/SOD2/MAP2K7/RAP1B/PPP3CB/RELA/TLR6/LYN/CCL2/BCL2L1/DDIT3/MAPK14/ERN1/IKBKG/BCL2/CASP7/MAP2K4/PPP3CC/TBK1/EIF2AK3/IKBKB/NCF4/ARHGEF1/IKBKE/BAX/POU2F1/IRAK4/TRAF6/KRAS/CHUK/CCL3L3/VAV2/TRAF3/AKT2/PPP3CA/TNFRSF10B/ITPR1/PIK3R2/NFATC1/TICAM1/CXCL1/HSP90AA1/PRKCA/PLCG1/NCF1/PIK3R3	8.95656099179485
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	69/2333	112/9376	2.4759047210826	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/NFKBIA/HLA-DQB1/TGFB2/HLA-DMA/MAPK3/HLA-DQA1/MAP2K3/IFNGR2/HSPA1B/HLA-DMB/LY96/LAMA5/HLA-DRB5/HLA-DQA2/SOCS1/BIRC3/ALOX5/MAPK8/PDPK1/PPIF/CD40/ITGB1/LAMC1/HSPA6/ITGA6/GNAI2/BIRC7/TLR4/HLA-DOA/XIAP/IFNGR1/AKT3/HSPA1A/STAT1/TNF/IL10/MAPK1/PIK3R5/TLR2/NFKB1/LAMA3/TNFRSF1A/CIITA/MAP3K7/JAK2/LDLR/STAT3/TAB2/LAMB3/IL10RB/RELA/LAMC2/LAMB2/IL10RA/BCL2L1/BIRC2/MAPK14/IKBKG/BCL2/IKBKB/NFKBIB/IRAK4/TRAF6/CHUK/AKT2	9.04341005529469
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	67/2333	109/9376	2.47030834024782	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/NFKBIA/IL6ST/TGFBR1/HLA-DQB1/HLA-DMA/MAPK3/HLA-DQA1/RXRA/JUN/IL1RAP/IL2RB/IFNGR2/EBI3/HLA-DMB/IL1B/HLA-DRB5/HLA-DQA2/CD4/AHR/FOS/MAPK8/SMAD3/STAT6/IL4R/IL27RA/SMAD4/IL6R/RXRB/IL2RG/HLA-DOA/IFNGR1/STAT1/GATA3/RARA/RUNX1/MAPK1/NFKB1/TGFBR2/NFKBIE/SMAD2/IL1R1/JAK2/NFATC3/PPP3R1/STAT3/PPP3CB/RELA/HIF1A/IL27/MAPK14/IKBKG/IL12RB1/LAT/PPP3CC/IKBKB/NFKBIB/STAT5A/CHUK/JAK3/PPP3CA/NFATC1/HSP90AA1/PLCG1	8.88620343779547
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	53/2333	78/9376	2.73076373547869	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/NFKBIA/HLA-DQB1/TGFB2/HLA-DMA/MAPK3/ITGB2/HLA-DQA1/JUN/FCGR3A/IFNGR2/HLA-DMB/IL1B/NCF2/CYBB/HLA-DRB5/FCGR1A/HLA-DQA2/FCGR2A/EEF1A1/FOS/ITGAM/ITGB1/TLR4/PTGS2/HLA-DOA/IFNGR1/STAT1/TNF/IL10/MAPK1/TLR2/NFKB1/PTPN6/MAP3K7/JAK2/C3/PRKCB/MARCKSL1/TAB2/RELA/IL1A/MAPK14/ITGA4/NFKBIB/NCF4/IRAK4/TRAF6/FCGR3B/NCF1	8.83394072219981
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	119/2333	250/9376	1.91297728246892	HLA-B/HLA-A/ASAP3/TGFBR1/ARFGAP3/RAB5A/CXCR4/IGF2R/IL2RB/HSPA1B/CLTB/GRK4/HLA-F/AGAP3/IST1/SH3KBP1/ARRB2/EGFR/SMAD3/CYTH1/SH3GL1/SH3GLB2/AP2B1/HSPA6/AP2A2/RABEP1/GIT2/ARAP1/SMAP2/IL2RG/HLA-E/IQSEC1/PARD6G/HSPA1A/EHD1/MDM2/CHMP3/WIPF2/CHMP1A/RAB11FIP1/CYTH2/CHMP1B/GIT1/RAB5B/PDCD6IP/CYTH3/VPS4B/RAB22A/CYTH4/PLD1/VPS36/TGFBR2/CLTC/ARPC2/ARAP2/SMAD2/EHD3/RAB31/SMURF2/WWP1/HGS/CHMP4C/LDLR/RUFY1/ACAP3/USP8/GBF1/SNX1/STAM/ARFGAP1/ARFGEF2/VPS37B/CBL/ARFGEF1/ARF4/TSG101/STAMBP/FOLR1/DNM2/VPS4A/ITCH/TFRC/FOLR2/RAB11B/ARFGAP2/SPG21/SMAP1/ARRB1/WIPF1/ASAP1/VPS37A/PARD6B/SH3GLB1/SNX12/RAB7A/EPS15/NEDD4L/SMURF1/DNAJC6/EPN2/VPS35/RAB11FIP4/ZFYVE27/TRAF6/VPS45/ACAP1/EPS15L1/VPS37C/CXCR2/AP2S1/ASAP2/PIP5KL1/RAB11FIP3/IQSEC2/PIP5K1B/ACTR3C/FGFR2/AGAP5/AGAP6	8.42081074191881
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	94/2333	181/9376	2.08714267784111	HLA-DRA/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/FCER1G/CTSS/ATP6V0D1/CTSD/HLA-DQB1/TGFB2/HLA-DMA/MAPK3/LAMP2/ITGB2/HLA-DQA1/RAB5A/FCGR3A/IFNGR2/CAMK2G/MRC2/LSP1/HLA-DMB/IL1B/PLK3/CD14/IL18/HLA-DRB5/FCGR1A/HLA-DQA2/ITGAX/FCGR2A/SYK/CORO1A/ITGAM/LAMP1/MAPK8/ATP6AP1/CEBPB/BID/CREBBP/EP300/TLR4/HLA-DOA/IFNGR1/ATP6V0A1/AKT3/STAT1/TNF/IL10/MAPK1/TLR2/NFKB1/RAB5B/TLR1/TNFRSF1A/KSR1/CIITA/ATP6V1H/TRADD/RAF1/CAMK2D/JAK2/ATP6V0B/PPP3R1/C3/VDR/SPHK1/IL10RB/CARD9/PPP3CB/RELA/ARHGEF12/TLR6/IL10RA/IL1A/MAPK14/FADD/FCGR2B/BCL2/PPP3CC/RAB7A/CLEC4E/BAX/PIK3C3/IRAK4/TRAF6/AKT2/PPP3CA/ATP6V0A2/CLEC7A/FCGR3B/SPHK2/PLA2R1	8.49990612280972
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	64/2333	105/9376	2.44959075786337	NFKBIA/GADD45B/CXCL2/BCL2A1/CXCL3/CFLAR/IL1B/LY96/TNFSF13B/ICAM1/CD14/SYK/BIRC3/GADD45A/CCL4/BTK/CD40/TLR4/PTGS2/XIAP/TNFAIP3/TNF/CYLD/TRIM25/BLNK/NFKB1/TNFRSF1A/NFKB2/PPP1R13L/TRADD/CSNK2A2/IL1R1/ATM/MAP3K7/PRKCB/TAB2/TNFSF14/RELA/PLAU/RIPK1/LYN/BCL2L1/BIRC2/PLCG2/IKBKG/BCL2/LAT/TRAF1/IKBKB/TAB3/RELB/EDA2R/IRAK4/TRAF6/CHUK/TRAF3/GADD45G/CARD14/EDARADD/LTB/TNFRSF11A/TICAM1/CXCL1/PLCG1	8.59688136892762
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	136/2333	300/9376	1.82188312616088	RASGRF2/GADD45B/DUSP1/MAP3K2/RASA1/TGFBR1/TGFB2/MAPK3/JUN/MAP2K3/IL1RAP/DUSP2/HSPA1B/IL1B/HSPB1/PDGFB/CD14/EREG/JUND/IGF2/FLT1/FOS/RAC2/ARRB2/EGFR/MAPK8/GADD45A/MAPK8IP3/MAPK8IP2/SOS1/HSPA6/TAOK1/MRAS/MAP2K1/PAK2/AKT3/HSPA1A/MAP3K5/DUSP10/TNF/RAPGEF2/DUSP3/CSF1R/MAPK1/RASGRP3/RPS6KA3/GNG12/NFKB1/DUSP4/VEGFA/ERBB3/MAPKAPK3/TGFBR2/MEF2C/ELK4/ATF4/TNFRSF1A/NFKB2/TRADD/IL1R1/RAF1/PPM1A/MAP3K7/MET/MAP3K3/MAPKAPK2/RPS6KA5/RAP1A/NFATC3/PPP3R1/MAP4K3/PTPN7/AREG/PRKCB/RASGRF1/TAB2/LAMTOR3/MAX/CACNA2D4/MAP2K7/RAP1B/PPP3CB/RELA/ATF2/CRK/STK3/MAP3K9/IL1A/DUSP7/NF1/MAP3K10/MAP3K11/CACNA1A/DDIT3/MAPK14/ARRB1/IKBKG/PRKACA/PTPRR/CSF1/TAOK3/MAP2K4/DUSP6/PPP3CC/PPM1B/PRKACB/IKBKB/RELB/RPS6KA2/MAP3K1/FGFR1/DUSP9/IRAK4/ARAF/TRAF6/KRAS/PLA2G4C/CHUK/CACNA2D3/AKT2/PDGFC/PPP3CA/GADD45G/TAOK2/RASA2/NLK/MAP2K5/ANGPT2/EFNA5/DUSP8/NFATC1/FGF1/PRKCA/MAPT/FGFR2/NTF4	8.32698172109775
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	99/2333	196/9376	2.02993430548387	HLA-B/CDKN1A/NFKBIA/HLA-A/IL6ST/CXCL2/ZFP36/PIK3R1/MAPK3/ITPR2/JUN/MAP1LC3B/CXCL3/PDGFB/ICAM1/CLEC2B/HLA-F/CD86/SYK/TCF7L2/FOS/HCK/MAPK8/RB1/BID/CREBBP/EP300/MAP2K1/PTGS2/HLA-E/IFNGR1/AKT3/STAT1/PIK3CA/MAPK1/PIK3R5/CCR1/TCF7/GNG12/NFKB1/VEGFA/UBC/TNFRSF1A/TRADD/RCAN1/RAF1/JAK2/MAPKAPK2/NFATC3/PPP3R1/STAT3/C3/IFNAR1/PIK3CD/STAT2/UBB/GNGT2/EIF2AK2/MAP2K7/PPP3CB/RELA/HIF1A/TCF7L1/PREX1/BECN1/GNG10/MICB/LYN/MAPK14/PLCG2/FADD/IKBKG/ITPR3/MAP2K4/PPP3CC/TBK1/IKBKB/ATG14/IKBKE/BAX/PIK3C3/MICA/KRAS/CHUK/TRAF3/AKT2/PPP3CA/ITPR1/PIK3R2/CDK6/ANGPT2/NFATC1/TICAM1/MAP1LC3B2/TLR3/GNG7/CXCL1/PLCG1/PIK3R3	8.386492878493
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	77/2333	138/9376	2.2424073004218	NFKBIA/PIK3R1/GNAQ/MAPK3/JUN/VAV3/MAP2K3/IL1B/PYCARD/IL18/CD4/FCGR2A/LCP2/FN1/FOS/PKN1/RAC2/CASP1/MAPK8/WAS/SKAP2/PTK2/ITGB1/ARHGEF7/GIT2/MAP2K1/TLR4/BAIAP2/AKT3/WIPF2/PIK3CA/TNF/IL10/MAPK1/RPS6KA3/NFKB1/VAV1/NLRP3/ARPC2/MAP3K7/LIMK1/NFATC3/PIK3CD/TAB2/PKN2/MAP2K7/RELA/WASF2/CRK/BCAR1/ARHGEF12/PTK2B/CCL2/MAPK14/ITGA4/WIPF1/IKBKG/LAT/MAP2K4/TBK1/IKBKB/RPS6KA2/ARHGEF1/IRAK4/ITGA5/TRAF6/CHUK/VAV2/AKT2/PIK3R2/ELMO2/NFATC1/TICAM1/PIP5K1B/PLCG1/ACTR3C/PIK3R3	8.46211108767986
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	109/2333	224/9376	1.95560590288409	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/CDKN1A/HLA-DPB1/NFKBIA/HLA-A/CREB5/ANAPC13/ZFP36/PIK3R1/TGFBR1/HLA-DQB1/TGFB2/HLA-DMA/MAPK3/ITGB2/HLA-DQA1/JUN/ETS2/IL2RB/HLA-DMB/CDKN2A/SPI1/ADCY7/ICAM1/HLA-DRB5/HLA-DQA2/HLA-F/CD4/FOS/MAPK8/SMAD3/ANAPC16/EGR1/RB1/CD40/VAC14/CREBBP/EP300/SMAD4/B2M/MAP2K1/IL2RG/HLA-E/HLA-DOA/XIAP/TLN2/AKT3/MMP7/PIK3CA/TNF/TSPO/MAPK1/ITGAL/NRP1/NFKB1/CREB3L2/TGFBR2/ELK4/ATF4/TNFRSF1A/NFKB2/SMAD2/IL1R1/IL1R2/ATM/MAP3K3/NFATC3/PPP3R1/ATF6B/EGR2/PIK3CD/CDKN2B/PPP3CB/RELA/ATF2/KAT5/BCL2L1/TBP/DLG1/IKBKG/PRKACA/KAT2B/MAP2K4/PPP3CC/PRKACB/IKBKB/RELB/MAP3K1/STAT5A/BAX/RANBP3/KRAS/CHUK/CRTC2/JAK3/AKT2/PPP3CA/POLB/PIK3R2/CRTC1/ATR/IL15RA/NFATC1/ADCY9/FOSL1/PIK3R3	8.3312274375903
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	76/2333	137/9376	2.22944049358459	CSF2RB/CTSS/NFKBIA/GADD45B/TNFSF10/CTSD/ENDOG/PIK3R1/CTSB/MAPK3/ITPR2/CTSH/BCL2A1/JUN/CFLAR/CTSZ/FOS/BIRC3/MAPK8/GADD45A/CAPN2/PDPK1/TUBA1A/BID/CTSO/PARP4/MAP2K1/XIAP/CTSF/AKT3/MAP3K5/PIK3CA/TNF/DAB2IP/BCL2L11/MAPK1/NFKB1/ATF4/TNFRSF1A/MCL1/TRADD/RAF1/ATM/BBC3/PIK3CD/PMAIP1/TNFRSF10A/RELA/CASP2/RIPK1/TUBA4A/BCL2L1/CTSL/DDIT3/BIRC2/ERN1/FADD/IKBKG/ITPR3/BCL2/CASP7/EIF2AK3/TRAF1/IKBKB/BAX/KRAS/CHUK/DFFB/AKT2/TNFRSF10B/GADD45G/ITPR1/PIK3R2/NOL3/DIABLO/PIK3R3	8.34294684562362
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	56/2333	93/9376	2.41995861159889	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/NFKBIA/HLA-DQB1/HLA-DMA/MAPK3/HLA-DQA1/JUN/NOTCH2/IL2RB/IFNGR2/HLA-DMB/HLA-DRB5/HLA-DQA2/CD4/STAT4/FOS/MAML2/MAPK8/STAT6/IL4R/IL2RG/HLA-DOA/IFNGR1/STAT1/GATA3/RBPJ/MAPK1/NFKB1/NFKBIE/JAK2/NFATC3/PPP3R1/RUNX3/MAF/PPP3CB/RELA/MAPK14/IKBKG/IL12RB1/LAT/PPP3CC/MAML1/IKBKB/NFKBIB/STAT5A/JAG2/CHUK/JAK3/PPP3CA/NOTCH1/NFATC1/JAG1/PLCG1	7.92021823492144
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	141/2333	333/9376	1.70167939049208	SPP1/HLA-B/CDKN1A/HLA-A/CREB5/ATP6V0D1/PIK3R1/MAPK3/NOTCH2/HES2/LLGL2/LAMA5/FOXO1/RHEB/HLA-F/MX2/TCF7L2/PTGER4/ATP6V0E1/FN1/ATP6V1G1/HES4/PPP2CB/MAML2/IRF1/EGFR/ATP6AP1/PTK2/RBL2/RB1/SOS1/ITGB1/CREBBP/LAMC1/ITGA6/ATP6V1B2/EP300/UBR4/MAP2K1/COL4A2/PTGS2/HLA-E/ATP6V0A1/AKT3/PARD6G/STAT1/MDM2/PIK3CA/TNF/RBPJ/ITGB6/COL4A1/LFNG/CHD4/ITGA3/PPP2R5E/MAPK1/TCF7/NFKB1/LAMA3/CREB3L2/VEGFA/TNFRSF1A/ATP6V1H/TRADD/RAF1/ATP6V1C1/ATM/MFNG/CSNK1A1/ATP6V0B/PSEN1/THBS3/IFNAR1/PIK3CD/UBE3A/ATP6V1A/ATP6V1E1/FZD1/STAT2/ATP6V1D/EIF2AK2/WNT2B/LAMB3/ITGA2/APC/PPP2R2D/RELA/TCF7L1/OASL/TSC1/PPP2R3C/LAMC2/ITGA1/ITGB4/DVL1/LAMB2/TSC2/TBP/RFNG/DLG1/ITGA4/FADD/IKBKG/PRKACA/ITGB7/RPS6KB1/TBK1/WNT6/PRKACB/MAML1/PARD6B/IKBKB/FZD8/IKBKE/BAX/NFX1/ITGA5/KRAS/CHUK/TRAF3/AKT2/PIK3R2/ATP6V0A2/NOTCH1/HES1/FZD6/ATR/CDK6/ATP6V1E2/WNT5B/FZD7/ATP6V0E2/TICAM1/PPP2R5B/TLR3/JAG1/FZD5/VWF/TUBG2/PIK3R3	7.50358377211636
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	56/2333	95/9376	2.3690121145126	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/ATP6V0D1/CCL3/CXCL2/HLA-DQB1/TGFB2/HLA-DMA/ITGB2/HLA-DQA1/JUN/CXCL3/HLA-DMB/IL1B/TNFSF13B/ICAM1/IL18/HLA-DRB5/CCL20/HLA-DQA2/CD86/ATP6V0E1/FLT1/FOS/ATP6V1G1/CCL5/ATP6AP1/ATP6V1B2/ACP5/TLR4/HLA-DOA/ATP6V0A1/TNF/ITGAL/TLR2/VEGFA/ATP6V1H/ATP6V1C1/ATP6V0B/ATP6V1A/ATP6V1E1/ATP6V1D/IL1A/CCL2/CTSL/CSF1/IL11/CCL3L3/ATP6V0A2/ATP6V1E2/LTB/TNFRSF11A/ATP6V0E2/CXCL1	7.71855265081944
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	60/2333	105/9376	2.29649133549691	FCER1G/NFKBIA/PIK3R1/MAPK3/ITPR2/JUN/LSP1/IL1B/PLK3/BCL3/PYCARD/SYK/IRF1/CASP1/MAPK8/MRAS/PTGS2/AKT3/STAT1/MDM2/PIK3CA/TNF/CYLD/IL10/MAPK1/NFKB1/NLRP3/NFKB2/KSR1/RAF1/MAPKAPK2/NFATC3/PPP3R1/EGR2/EGR3/PIK3CD/STAT2/IL17D/CARD9/PPP3CB/RELA/ARHGEF12/MAPK14/PLCG2/IKBKG/ITPR3/PPP3CC/IKBKB/RELB/CLEC4E/IKBKE/KRAS/CHUK/AKT2/PPP3CA/ITPR1/PIK3R2/CLEC7A/NFATC1/PIK3R3	7.68891643841455
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	54/2333	91/9376	2.38481792532371	NFKBIA/PIK3R1/DAPP1/MAPK3/JUN/VAV3/LILRB4/LILRB3/SYK/CD22/PIK3AP1/FOS/RAC2/CD72/SOS1/BTK/MAP2K1/INPPL1/AKT3/PIK3CA/LILRB1/LILRB2/MAPK1/RASGRP3/BLNK/NFKB1/VAV1/PTPN6/NFKBIE/RAF1/NFATC3/PPP3R1/LILRA2/PIK3CD/PRKCB/INPP5D/PPP3CB/RELA/LYN/LILRA6/PLCG2/IKBKG/FCGR2B/PPP3CC/IKBKB/NFKBIB/KRAS/CHUK/VAV2/AKT2/PPP3CA/PIK3R2/NFATC1/PIK3R3	7.63988078928248
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	111/2333	248/9376	1.79876387871078	NFKBIA/TNFSF10/RHOB/MAPK3/TUBB2A/DYNLT1/RAB5A/JUN/MAP2K3/IL1B/LY96/PTPRC/PYCARD/CD14/IL18/AHNAK2/TCF7L2/NCKAP1L/FOS/PKN1/BIRC3/AHNAK/CASP1/MAPK8/DYNC1LI2/CYTH1/TUBA1A/PLEKHM2/MAP2K1/TLR4/AKT3/PIK3CA/TNF/CYTH2/MAPK1/TCF7/TLR2/NFKB1/RAB5B/CYTH3/CYTH4/ARL8B/STX10/NLRP3/TNFRSF1A/ARPC2/TRADD/RAF1/MAP3K7/ABI1/DCTN4/PLEKHM1/PIK3CD/TNFRSF10A/TAB2/TLR5/ARL8A/MYO6/NAIP/MAP2K7/RELA/DNM2/TCF7L1/DCTN1/DYNLRB1/KLC4/DCTN6/MLKL/TLR6/RIPK1/VPS39/CYFIP2/KPNA3/TUBA4A/BIRC2/MAPK14/FADD/IKBKG/RILP/PIK3C2A/BRK1/CYFIP1/SNX33/VPS11/BCL2/CASP7/MAP2K4/FHOD1/EXOC2/IKBKB/TAB3/RAB7A/BAX/PIK3C3/IRAK4/KLC1/ACBD3/TRAF6/SKP1/CHUK/AKT2/S100A10/TNFRSF10B/ELMO2/FYCO1/TXN/RIPK3/HSP90AA1/ACTR3C/MYL10/DYNLRB2	7.33703524507665
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	70/2333	133/9376	2.11518938795768	CDKN1A/PRKAG2/GADD45B/TNFSF10/GABARAPL2/FOXO3/PIK3R1/GABARAP/TGFBR1/HOMER3/TGFB2/MAPK3/GABARAPL1/FBXO32/SGK1/FOXO1/PLK3/IRS2/BCL6/EGFR/MAPK8/SMAD3/GADD45A/PDPK1/RBL2/SOS1/CREBBP/EP300/SMAD4/MAP2K1/AKT3/MDM2/PIK3CA/KLF2/SGK3/IL10/BCL2L11/MAPK1/IL7R/USP7/TGFBR2/RAF1/ATM/HOMER1/STAT3/PIK3CD/CDKN2B/SOD2/STK11/S1PR4/CAT/SIRT1/CCNG2/MAPK14/IKBKB/FBXO25/PRKAA1/ARAF/PRKAB2/KRAS/CHUK/AKT2/GADD45G/PIK3R2/PCK2/NLK/PRKAB1/PLK2/SGK2/PIK3R3	7.45473372317459
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	78/2333	155/9376	2.0223939825505	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/CTSS/HLA-A/ATP6V0D1/OLR1/HLA-DQB1/HLA-DMA/TUBB2A/LAMP2/ITGB2/SCARB1/HLA-DQA1/RAB5A/MSR1/FCGR3A/MRC2/HLA-DMB/CD36/NCF2/CD14/CYBB/HLA-DRB5/FCGR1A/HLA-DQA2/HLA-F/FCGR2A/ATP6V0E1/MARCO/CORO1A/ATP6V1G1/ITGAM/LAMP1/DYNC1LI2/ATP6AP1/TUBA1A/ITGB1/ATP6V1B2/STX7/TLR4/HLA-E/HLA-DOA/ATP6V0A1/TLR2/RAB5B/STX12/ATP6V1H/ATP6V1C1/HGS/ATP6V0B/THBS3/C3/ATP6V1A/ATP6V1E1/ATP6V1D/ITGA2/STX18/TFRC/TLR6/TUBA4A/CTSL/RILP/FCGR2B/RAB7A/PIKFYVE/NCF4/PIK3C3/ITGA5/ATP6V0A2/CLEC7A/ATP6V1E2/FCGR3B/ATP6V0E2/PLA2R1/NCF1	7.38685010239525
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	56/2333	98/9376	2.29649133549691	MARCKS/ASAP3/PIK3R1/MAPK3/VAV3/GSN/FCGR3A/PTPRC/FCGR1A/FCGR2A/SYK/RAC2/HCK/WAS/MAP2K1/INPPL1/AKT3/SCIN/PIK3CA/MAPK1/VAV1/PLD1/ARPC2/RAF1/LIMK1/PIK3CD/PRKCB/MARCKSL1/LIMK2/INPP5D/SPHK1/DNM2/WASF2/CRK/LYN/PLCG2/ASAP1/FCGR2B/RPS6KB1/LAT/PRKCE/PLA2G4C/VAV2/AKT2/PIK3R2/FCGR3B/PLA2G6/ASAP2/WASF1/PRKCA/PIP5K1B/PLCG1/SPHK2/ACTR3C/NCF1/PIK3R3	7.42539627560119
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	103/2333	227/9376	1.82353552080757	HLA-B/CDKN1A/TAPBP/NFKBIA/HLA-A/CREB5/CCL3/PIK3R1/AKAP13/GNAQ/MAPK3/ITPR2/CXCR4/TAPBPL/IL1B/CDKN2A/ADCY7/RHEB/PTGER3/HLA-F/PTGER4/GNA13/RAC2/EGFR/CCL5/PTK2/RB1/CCL4/SOS1/BID/GNAI2/B2M/IL6R/MAP2K1/PTGS2/HLA-E/AKT3/MDM2/PIK3CA/TNF/MAPK1/CCR1/GNG12/NFKB1/CREB3L2/VEGFA/ATF4/TNFRSF1A/SP1/TRADD/GNA11/PLCB2/IL1R1/RAF1/NFATC3/PPP3R1/ATF6B/STAT3/PIK3CD/PRKCB/GNGT2/IL10RB/PPP3CB/RELA/ATF2/CRK/TSC1/BCAR1/ARHGEF12/GNG10/RIPK1/PTK2B/IL10RA/PTGER2/CCL2/TSC2/MAPK14/FADD/IKBKG/ITPR3/PRKACA/RPS6KB1/PPP3CC/TBK1/PRKACB/IKBKB/ARHGEF1/BAX/KRAS/CHUK/CCL3L3/AKT2/PPP3CA/ARHGEF11/ITPR1/PIK3R2/CDK6/CXCR2/NFATC1/GNG7/ADCY9/PRKCA/PIK3R3	7.22890660983967
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	84/2333	173/9376	1.95135390935286	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/NFKBIA/TNFSF10/PIK3R1/HLA-DQB1/HLA-DMA/MAPK3/HLA-DQA1/IFNGR2/HLA-DMB/IL1B/PYCARD/DNAJB1/ICAM1/IL18/HLA-DRB5/HLA-DQA2/MX2/CASP1/OAS2/CCL5/HNRNPUL1/BID/CREBBP/EP300/MAP2K1/TLR4/HLA-DOA/IFNGR1/AKT3/STAT1/PIK3CA/TNF/TRIM25/MAPK1/NFKB1/NLRP3/CXCL10/TNFRSF1A/CIITA/IFIH1/TRADD/RAF1/TLR7/ADAR/JAK2/IFNAR1/PIK3CD/PRKCB/TNFRSF10A/STAT2/EIF2AK2/NLRX1/RELA/KPNA6/NXF1/RAB11B/IL1A/CCL2/CALCOCO2/FADD/IKBKG/TBK1/RSAD2/IKBKB/NFKBIB/IKBKE/BAX/IRAK4/RNASEL/CHUK/TRAF3/AKT2/TNFRSF10B/PIK3R2/CDK6/TICAM1/TLR3/PRKCA/KPNA5/PIK3R3	7.26883166026063
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	95/2333	205/9376	1.8623984611042	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/CDKN1A/HLA-DPB1/TAPBP/NFKBIA/HLA-A/GADD45B/VIM/PIK3R1/HLA-DQB1/HLA-DMA/HLA-DQA1/JUN/TAPBPL/MAP2K3/HLA-DMB/CD44/ENTPD1/ICAM1/HLA-DRB5/HLA-DQA2/HLA-F/SYK/MAPK8/OAS2/GADD45A/CD58/RB1/BTK/CD40/BID/B2M/HLA-E/HLA-DOA/AKT3/TNFAIP3/STAT1/MDM2/PIK3CA/TNF/RBPJ/BCL2L11/ITGAL/BLNK/TLR2/NFKB1/USP7/NFKBIE/CXCL10/NFKB2/TRADD/MAP3K7/CIR1/NCOR2/STAT3/IFNAR1/PIK3CD/TAB2/STAT2/EIF2AK2/RUNX3/MAP2K7/RELA/RIPK1/LYN/SAP30L/MAPK14/PLCG2/ENTPD8/FADD/IKBKG/BCL2/MAP2K4/TBK1/DDB2/IKBKB/RELB/NFKBIB/IKBKE/BAX/IRAK4/TRAF6/CHUK/TRAF3/JAK3/AKT2/SIN3A/GADD45G/PIK3R2/HES1/CDK6/PIK3R3	7.18523075395481
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	80/2333	163/9376	1.97244654582556	CDKN1A/NFKBIA/CREB5/PIK3R1/TGFBR1/TGFB2/MAPK3/HSPG2/JUN/MAP2K3/MMP9/STAT4/FOS/MAPK8/SMAD3/STAT6/ATP6AP1/RB1/SOS1/DDB1/BID/CREBBP/EP300/SMAD4/MAP2K1/TLR4/AKT3/STAT1/PIK3CA/TNF/MAPK1/TLR2/NFKB1/CREB3L2/TGFBR2/ATF4/IFIH1/RAF1/MAP3K7/JAK2/NFATC3/ATF6B/EGR2/EGR3/STAT3/IFNAR1/PIK3CD/PRKCB/TAB2/STAT2/MAP2K7/RELA/ATF2/PTK2B/MAPK14/FADD/IKBKG/BCL2/MAP2K4/TBK1/DDB2/IKBKB/MAP3K1/STAT5A/IKBKE/BAX/IRAK4/ARAF/TRAF6/KRAS/CHUK/TRAF3/JAK3/AKT2/PIK3R2/NFATC1/TICAM1/TLR3/PRKCA/PIK3R3	7.20813925174506
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	87/2333	187/9376	1.86973692956901	NFKBIA/CXCL2/GABARAPL2/GABARAP/CTSB/MAPK3/ITPR2/GABARAPL1/JUN/MAP1LC3B/CXCL3/IL1B/TXNIP/PYCARD/IFI16/GPSM3/CYBB/IL18/PKN1/BIRC3/CASP1/MAPK8/OAS2/CCL5/NAMPT/GBP3/P2RX7/TLR4/XIAP/TNFAIP3/STAT1/NEK7/TNF/MAPK1/ANTXR1/NFKB1/NLRP3/GBP5/PLCB2/PSTPIP1/MAP3K7/GBP2/IFNAR1/TAB2/STAT2/TRPM7/PKN2/NLRX1/NAIP/CARD9/RELA/RIPK1/CCL2/BCL2L1/BIRC2/MAPK14/FADD/IKBKG/ITPR3/RBCK1/MFN2/BCL2/TBK1/GBP4/IKBKB/TAB3/NFKBIB/IKBKE/IRAK4/RNASEL/TRAF6/CHUK/CARD16/TRAF3/CARD6/ATG16L1/ITPR1/TP53BP1/TXN/RIPK3/CARD8/TICAM1/MAP1LC3B2/CXCL1/HSP90AA1/NLRP7/TRPV2	6.91414927742616
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	51/2333	90/9376	2.2773539077011	NFKBIA/PIK3R1/MAPK3/JUN/MAP2K3/IFNGR2/CD4/FOS/EGFR/MAP2K1/TLR4/CD274/IFNGR1/AKT3/STAT1/PIK3CA/BATF3/MAPK1/TLR2/NFKB1/PTPN6/NFKBIE/BATF/CSNK2A2/RAF1/JAK2/MAP3K3/NFATC3/PPP3R1/STAT3/PIK3CD/PPP3CB/RELA/HIF1A/MAPK14/IKBKG/RPS6KB1/LAT/PPP3CC/IKBKB/NFKBIB/TRAF6/KRAS/CHUK/AKT2/PPP3CA/PIK3R2/NFATC1/TICAM1/PLCG1/PIK3R3	7.00781001493043
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	84/2333	180/9376	1.87546792398914	HLA-DRA/HLA-B/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/TAPBP/NFKBIA/HLA-A/PIK3R1/HLA-DQB1/BST2/HLA-DMA/HLA-DQA1/TAPBPL/IFNGR2/HLA-DMB/IL1B/RHEB/HLA-DRB5/HLA-DQA2/HLA-F/TNFRSF14/SYK/BIRC3/OAS2/CCL5/PILRA/BID/B2M/HLA-E/HLA-DOA/IFNGR1/AKT3/STAT1/POU2F2/PIK3CA/TNF/TLR2/NFKB1/TNFRSF1A/IFIH1/TRADD/MAP3K7/JAK2/SP100/C3/IFNAR1/PIK3CD/TAB2/STAT2/EIF2AK2/TNFSF14/CARD9/RELA/TSC1/NXF1/CCL2/TSC2/BCL2L1/BIRC2/EIF2B1/FADD/IKBKG/HCFC2/BCL2/TBK1/IKBKB/IKBKE/BAX/POU2F1/IRAK4/RNASEL/ITGA5/TRAF6/CHUK/SRSF5/TRAF3/AKT2/PILRB/PIK3R2/TICAM1/TLR3/PIK3R3	6.8256053374582
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	58/2333	109/9376	2.13847587663244	SPP1/NFKBIA/CCL3/PIK3R1/MAPK3/JUN/MAP2K3/IL1B/LY96/CD14/CD86/FOS/MAPK8/CCL5/CCL4/CD40/MAP2K1/TLR4/AKT3/STAT1/PIK3CA/TNF/MAPK1/CXCL9/TLR2/NFKB1/IRF5/TLR1/CXCL10/TLR7/MAP3K7/IFNAR1/PIK3CD/TAB2/TLR5/STAT2/TLR8/MAP2K7/RELA/TLR6/RIPK1/MAPK14/FADD/IKBKG/MAP2K4/TBK1/IKBKB/IKBKE/IRAK4/TRAF6/CHUK/CCL3L3/TRAF3/AKT2/PIK3R2/TICAM1/TLR3/PIK3R3	6.88068480049106
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	55/2333	103/9376	2.14599311690852	SERPINE1/NFKBIA/CCL3/PIK3R1/TGFBR1/GNAQ/TGFB2/MAPK3/JUN/IFNGR2/C1QB/C1QA/CFLAR/IL1B/C1QC/FOS/PPP2CB/MAPK8/CCL5/GNAI2/TLR4/IFNGR1/AKT3/GNA15/PIK3CA/TNF/IL10/MAPK1/TLR2/NFKB1/TGFBR2/TNFRSF1A/SMAD2/GNA11/PLCB2/C3/PIK3CD/GNAL/PPP2R2D/RELA/TLR6/CCL2/MAPK14/FADD/IKBKG/MAP2K4/IKBKB/IRAK4/TRAF6/CHUK/CCL3L3/AKT2/PIK3R2/TICAM1/PIK3R3	6.73061354285378
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	94/2333	214/9376	1.76529357331421	HLA-B/TAPBP/NFKBIA/HLA-A/PIK3R1/GNAQ/BST2/MAPK3/ITPR2/JUN/CXCR4/TAPBPL/MAP2K3/SAMHD1/HLA-F/CD4/FOS/RAC2/MAPK8/AP1S2/PTK2/DDB1/BID/GNAI2/B2M/MAP2K1/TLR4/HLA-E/PAK2/AKT3/PIK3CA/TNF/MAPK1/TLR2/GNG12/NFKB1/TNFRSF1A/TRADD/GNA11/RAF1/AP1B1/ATM/AP1G1/MAP3K7/FBXW11/LIMK1/NFATC3/PPP3R1/TNFRSF1B/CUL5/PIK3CD/PRKCB/LIMK2/TAB2/GNGT2/APOBEC3A/APOBEC3B/MAP2K7/PPP3CB/RELA/CRK/GNG10/RIPK1/PTK2B/BCL2L1/MAPK14/PLCG2/FADD/IKBKG/APOBEC3G/ITPR3/RPS6KB1/BCL2/PPP3CC/TBK1/IKBKB/BAX/IRAK4/TRAF6/KRAS/SKP1/CHUK/AKT2/PPP3CA/APOBEC3C/ITPR1/PIK3R2/BTRC/ATR/NFATC1/GNG7/PRKCA/PLCG1/PIK3R3	6.51784416381392
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	69/2333	142/9376	1.95282625888205	HERC1/ANAPC13/UBE2A/SOCS1/BIRC3/ANAPC16/UBE2E2/UBE2K/DDB1/UBE2L6/BIRC7/UBE2Q1/XIAP/MDM2/UBE2D1/UBE2H/UBE2G2/UBC/SYVN1/BIRC6/CDC34/SMURF2/UBE2R2/UBR5/WWP1/TRIP12/UBE2W/FBXW11/PIAS1/CUL5/UBE3A/CBL/UBE2Z/UBB/UBE2B/KLHL9/SIAH1/ITCH/WWP2/UBA7/PPIL2/FBXW8/HUWE1/BIRC2/UBE3C/UBE2D4/UBE2J1/UBE4B/DDB2/NEDD4L/SMURF1/MAP3K1/UBA6/VHL/UBE3B/HERC2/UBE2D3/TRAF6/SKP1/MGRN1/MID1/BTRC/CUL7/FZR1/TRIM32/PIAS3/FBXO2/UBOX5/DET1	6.58456543402711
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	106/2333	253/9376	1.68379107800267	NFKBIA/SQSTM1/FOXO3/PIK3R1/MAPK3/ITPR2/PLCD3/JUN/MAP1LC3B/RRAGC/IL1B/CD44/FOXO1/PYCARD/CD14/IL18/TECPR1/CASP1/EGFR/MAPK8/CCL5/RRAGD/CAPN2/PTK2/CYTH1/ITGB1/FNBP1/ARHGEF2/TLR4/TLN2/AKT3/MDM2/PIK3CA/TNF/UBE2D1/HK3/CYTH2/MAPK1/NFKB1/HCLS1/CYTH3/CYTH4/NLRP3/UBC/TNFRSF1A/ARPC2/TRADD/PLCB2/IL1R1/ATM/MAP3K7/TNIP1/RPS6KA5/FBXW11/C3/PIK3CD/TAB2/TLR5/UBB/NAIP/RELA/WASF2/CRK/BECN1/BCAR1/RIPK1/U2AF1L4/CAST/BCL2L1/MAPK14/PLCG2/CALCOCO2/IKBKG/ITPR3/RBCK1/RPS6KB1/UBE2D4/BCL2/TBK1/IKBKB/TAB3/ATG14/NFKBIB/PRKCE/BAX/PIK3C3/ITGA5/WIPI1/UBE2D3/TRAF6/SKP1/CHUK/AKT2/ATG16L1/ITPR1/PIK3R2/BTRC/RPTOR/ELMO2/RRAGB/MAP1LC3B2/WASF1/PLCG1/ACTR3C/MYL10/PIK3R3	6.34569240131549
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	44/2333	77/9376	2.29649133549691	CDKN1A/GADD45B/PIK3R1/TGFBR1/TGFB2/MAPK3/CDKN2A/RALGDS/RAC2/EGFR/MAPK8/SMAD3/GADD45A/RB1/SMAD4/MAP2K1/AKT3/STAT1/PIK3CA/MAPK1/NFKB1/VEGFA/PLD1/TGFBR2/SMAD2/RAF1/STAT3/PIK3CD/RELA/ARHGEF6/BCL2L1/IKBKG/RPS6KB1/DDB2/IKBKB/BAX/ARAF/KRAS/CHUK/AKT2/GADD45G/PIK3R2/CDK6/PIK3R3	6.57447413057296
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	41/2333	71/9376	2.32075004678737	NFKBIA/TJP1/ATP6V0D1/CXCL2/JAM2/JUN/CXCL3/HBEGF/ATP6V0E1/ATP6V1G1/EGFR/MAPK8/CCL5/ATP6AP1/ADAM10/ATP6V1B2/ATP6V0A1/GIT1/NFKB1/ATP6V1H/CSK/ATP6V1C1/MET/ATP6V0B/ATP6V1A/ATP6V1E1/ATP6V1D/RELA/LYN/MAPK14/PLCG2/IKBKG/MAP2K4/IKBKB/CHUK/ATP6V0A2/ATP6V1E2/CXCR2/ATP6V0E2/CXCL1/PLCG1	6.42918294215974
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	68/2333	144/9376	1.89779492308425	PRKAG2/NFKBIA/CXCL2/FOXO3/ACOX1/MAP2K3/LPIN2/C1QB/C1QA/CXCL3/IL1B/C5AR1/LY96/FOXO1/CPT1A/C1QC/CD14/C2/C3AR1/TCF7L2/MAPK8/TLR4/AKT3/MAP3K5/TNF/TCF7/NFKB1/TNFRSF1A/TRADD/MLYCD/MAP3K7/PPARA/C3/SREBF1/CAMKK2/TAB2/FASN/MAP2K7/RELA/ACADVL/TCF7L1/SIRT1/RIPK1/LPIN1/MAPK14/FADD/IKBKG/MAP2K4/TBK1/IKBKB/TAB3/IKBKE/PRKAA1/IRAK4/ACADM/PRKAB2/TRAF6/CHUK/TRAF3/AKT2/ACOX3/IL17RC/PRKAB1/CPT1B/TICAM1/ALDH3A2/CXCL1/ACACB	6.24848392286098
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	59/2333	120/9376	1.97593941991713	NFKBIA/FOXO3/PIK3R1/MAPK3/JUN/CAMK2G/ARHGDIB/MAPK8/PDPK1/SOS1/MATK/MAP2K1/AKT3/MAP3K5/PIK3CA/SH2B3/MAPK1/RPS6KA3/KIDINS220/NFKB1/ATF4/NFKBIE/RAF1/CAMK2D/MAP3K3/MAPKAPK2/RPS6KA5/RAP1A/PSEN1/PIK3CD/FRS2/MAGED1/MAP2K7/RAP1B/RELA/CRK/SH2B1/IRAK3/MAPK14/RAPGEF1/PLCG2/BCL2/IKBKB/PRDM4/RPS6KA2/GAB1/MAP3K1/NFKBIB/BAX/IRAK4/TRAF6/KRAS/AKT2/PSEN2/PIK3R2/MAP2K5/PLCG1/NTF4/PIK3R3	6.19249940785903
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	49/2333	93/9376	2.11746378514903	CDKN1A/NFKBIA/GADD45B/PIK3R1/RXRA/LAMA5/FN1/BIRC3/GADD45A/PTK2/RB1/ITGB1/LAMC1/ITGA6/BIRC7/COL4A2/RXRB/PTGS2/XIAP/AKT3/PIK3CA/COL4A1/ITGA3/NFKB1/LAMA3/PIK3CD/CDKN2B/MAX/LAMB3/ITGA2/RELA/LAMC2/LAMB2/BCL2L1/BIRC2/IKBKG/BCL2/DDB2/TRAF1/IKBKB/BAX/TRAF6/CHUK/TRAF3/AKT2/GADD45G/PIK3R2/CDK6/PIK3R3	6.23296832436252
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	86/2333	200/9376	1.72810972996142	NFKBIA/TNFSF10/TJP1/MAPK3/TUBB2A/CLDN19/JUN/IL1B/PYCARD/IL18/FCGR2A/NCKAP1L/FOS/GNA13/CASP1/MAPK8/CYTH1/SEC24D/TUBA1A/ITGB1/ARHGEF2/SEC24A/TLR4/BAIAP2/PAK2/LPAR2/WIPF2/TNF/CYTH2/MAPK1/NFKB1/RAB1A/HCLS1/CYTH3/CYTH4/MYO1F/MYO5A/PTPN6/NLRP3/TNFRSF1A/ARPC2/TRADD/IL1R1/CLDN23/MAP3K7/ABI1/MYO1D/MYO1C/TNFRSF10A/TAB2/TLR5/MYO6/MYO1G/NAIP/RELA/WASF2/ARHGEF12/RIPK1/CYFIP2/SEC24C/TUBA4A/CLDN9/MAPK14/FADD/WIPF1/IKBKG/BRK1/CYFIP1/CASP7/SEC24B/IKBKB/TAB3/MYO5B/NFKBIB/CLDN14/ARHGEF1/BAX/IRAK4/TRAF6/CHUK/ARHGEF11/TNFRSF10B/BAIAP2L1/CLDN15/WASF1/ACTR3C	5.99030994034964
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	53/2333	105/9376	2.0285673463556	SQSTM1/GABARAPL2/FOXO3/GABARAP/PINK1/RAB5A/GABARAPL1/JUN/MAP1LC3B/FIS1/MAPK8/AMFR/OPTN/MITF/MRAS/NBR1/CCZ1B/TBC1D15/RAB5B/ATF4/UBC/SP1/SMURF2/CSNK2A2/USP8/MUL1/UBB/NLRX1/MON1B/RELA/CCZ1/HIF1A/ULK1/BECN1/SIAH1/ARIH1/BCL2L1/HUWE1/CALCOCO2/RHOT1/MFN2/TFE3/TBK1/EIF2AK3/RAB7A/SMURF1/TBC1D17/KRAS/ATG9B/RHOT2/TFEB/MAP1LC3B2/USP30	6.09997781001667
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	38/2333	66/9376	2.31388899712946	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/TGFB2/HLA-DMA/HLA-DQA1/JUN/IFNGR2/HLA-DMB/IL1B/IL18/HLA-DRB5/HLA-DQA2/STAT4/SMAD3/STAT6/IL4R/TLR4/IL2RG/HLA-DOA/IFNGR1/STAT1/TNF/IL10/GATA3/TLR2/NFKB1/SMAD2/STAT3/TLR5/MAF/RELA/IL1A/IL12RB1/NFATC1/IL18R1	6.16481383671691
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	86/2333	201/9376	1.71951216911584	CDKN1A/GADD45B/ASPSCR1/REL/BCL2A1/NFKBIZ/RXRA/IL2RB/SPI1/FOXO1/HPGD/NR4A3/CD14/BCL6/FCGR1A/ARNT2/MMP9/CD86/IGFBP3/FLT1/CEBPA/BIRC3/ITGAM/GADD45A/PTK2/CD40/BMI1/CEBPB/MITF/RXRB/ETV6/MDM2/FUT8/CSF1R/RARA/RUNX1/JMJD1C/NFKB1/TGFBR2/MEF2C/ELK4/PBX3/LYL1/SP1/IL1R2/ATM/FLI1/MET/KMT2A/ID2/NCOR1/NUPR1/MAX/KLF3/MAF/PER2/RELA/AFF1/PLAU/ELANE/HHEX/BCL2L1/DDIT3/BIRC2/SUPT3H/DOT1L/SMAD1/ITGB7/DUSP6/TFE3/DDB2/TRAF1/CCNT1/CDK14/JUP/BAX/DDX5/LDB1/SS18L1/CCNT2/SIN3A/GADD45G/SIX4/FUS/PTCRA/ETV7	5.9346798988359
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	71/2333	157/9376	1.81744616837892	SERPINE1/HLA-B/CDKN1A/HLA-A/GADD45B/SQSTM1/FOXO3/PIK3R1/TGFBR1/HIPK3/TGFB2/MAPK3/ITPR2/MAP2K3/ZFP36L1/ZFP36L2/CDKN2A/FOXO1/RHEB/HLA-F/IGFBP3/SMAD3/GADD45A/CAPN2/HIPK2/RBL2/RB1/MRAS/MAP2K1/HLA-E/HIPK1/AKT3/MDM2/PIK3CA/MAPK1/NFKB1/TGFBR2/SMAD2/RAF1/ATM/RASSF5/MAPKAPK2/FBXW11/NFATC3/PPP3R1/PIK3CD/CDKN2B/TRPM7/RAD50/PPP3CB/RELA/TSC1/SIRT1/IL1A/TSC2/MAPK14/ITPR3/PPP3CC/RAD9A/KRAS/AKT2/PPP3CA/GADD45G/ITPR1/PIK3R2/BTRC/ATR/CDK6/NFATC1/LIN52/PIK3R3	5.94471781973847
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	83/2333	193/9376	1.72831796104107	NFKBIA/CCL3/CXCL2/FOXO3/PIK3R1/GNAQ/MAPK3/VAV3/CXCR4/CXCL3/CXCL16/ADCY7/GRK4/CCL20/XCR1/CCL18/FGR/RAC2/DOCK2/ARRB2/TIAM1/HCK/CCL5/CXCR6/WAS/PTK2/CCL4/SOS1/GNAI2/MAP2K1/AKT3/STAT1/PIK3CA/CCL7/MAPK1/PIK3R5/CXCL9/CCR1/GNG12/NFKB1/VAV1/CXCL10/PLCB2/RAF1/JAK2/RAP1A/STAT3/PIK3CD/PRKCB/STAT2/GNGT2/RAP1B/RELA/CRK/PREX1/BCAR1/GNG10/PTK2B/LYN/CCL2/PLCG2/ARRB1/IKBKG/PRKACA/PRKACB/IKBKB/NFKBIB/KRAS/CHUK/CCL3L3/VAV2/JAK3/AKT2/PIK3R2/CXCR2/GNG7/CXCL1/ADCY9/PLCG1/CCL28/NCF1/XCL1/PIK3R3	5.88398485165213
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	42/2333	77/9376	2.19210536570159	CDKN1A/NFKBIA/GADD45B/PIK3R1/TGFBR1/TGFB2/MAPK3/CDKN2A/SMAD3/GADD45A/RB1/SOS1/SMAD4/MAP2K1/AKT3/MDM2/PIK3CA/RUNX1/MAPK1/NFKB1/TGFBR2/RAF1/PIK3CD/CBL/RELA/CRK/BCL2L1/IKBKG/DDB2/IKBKB/CTBP2/STAT5A/BCR/BAX/ARAF/KRAS/CHUK/AKT2/GADD45G/PIK3R2/CDK6/PIK3R3	6.04513556947025
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	51/2333	101/9376	2.02932526428811	SERPINE1/PIM1/PIK3R1/TGFBR1/TGFB2/MAPK3/PLCD3/JUN/IL1B/FOXO1/ICAM1/CYBB/FN1/MAPK8/SMAD3/EGR1/SMAD4/COL4A2/AKT3/STAT1/PIK3CA/TNF/COL4A1/MAPK1/NFKB1/VEGFA/TGFBR2/SMAD2/PLCB2/JAK2/STAT3/PIK3CD/PRKCB/RELA/IL1A/CCL2/MAPK14/PLCG2/BCL2/PRKCE/STAT5A/BAX/KRAS/AKT2/PIK3R2/EDN1/NFATC1/AGTR1/PRKCA/PLCG1/PIK3R3	5.98577686807719
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	44/2333	83/9376	2.13047991365376	JARID2/PHC2/BMI1/LCOR/CREBBP/EP300/UBE2D1/L3MBTL3/USP16/PHF1/USP7/DCAF7/ASXL2/KDM2A/MGA/BCORL1/SUZ12/FOXK2/MAX/CBX4/FBRS/YAF2/PHC3/MBD6/FBRSL1/RING1/UBE2D4/SCML1/FOXK1/UBE2D3/SKP1/E2F6/SFMBT2/KDM2B/OGT/BCOR/PHC1/PCGF5/L3MBTL1/EZH1/SCMH1/CBX8/WDR5B/CBX7	5.95371568242315
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	86/2333	204/9376	1.69422522545238	TIMP3/CDKN1A/PIK3R1/TGFB2/MAPK3/HSPG2/ITPR2/VAV3/CAMK2G/CD44/HBEGF/MMP9/IGF2/FN1/TIAM1/EGFR/PDPK1/PTK2/SDC2/SOS1/ITGB1/MRAS/MAP2K1/TLR4/AKT3/MDM2/PIK3CA/TNF/MAPK1/PPP1R12B/TLR2/HCLS1/VEGFA/ERBB3/VAV1/PTPN6/SMAD2/RAF1/CAMK2D/MET/PDCD4/STAT3/PIK3CD/PRKCB/FZD1/CBL/FRS2/WNT2B/ITGA2/PLAUR/HIF1A/PLAU/ARHGEF12/NUDT16L1/SLC9A1/CTSL/MAPK14/PLCG2/ITPR3/PRKACA/RPS6KB1/WNT6/PRKACB/GAB1/FZD8/FGFR1/ARHGEF1/ARAF/ITGA5/KRAS/DDX5/VAV2/AKT2/MSN/ITPR1/PIK3R2/DROSHA/FZD6/PTCH1/GPC3/WNT5B/FZD7/FZD5/PRKCA/PLCG1/PIK3R3	5.76962536432065
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	38/2333	68/9376	2.24583343839036	PIM1/PIK3R1/MAPK3/BCL2A1/SPI1/CD14/FCGR1A/TCF7L2/CEBPA/ITGAM/SOS1/MAP2K1/AKT3/PIK3CA/CSF1R/RARA/RUNX1/MAPK1/TCF7/NFKB1/RAF1/STAT3/PIK3CD/PER2/RELA/TCF7L1/IKBKG/RPS6KB1/DUSP6/IKBKB/JUP/STAT5A/ARAF/KRAS/CHUK/AKT2/PIK3R2/PIK3R3	5.93403926505809
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	55/2333	115/9376	1.92206340036154	CDKN1A/CREB5/WNK1/AKAP13/GNAQ/MAPK3/ITPR2/RXRA/SGK1/NR4A2/MAFB/ADCY7/HBEGF/JUND/FOS/GNA13/WNK2/ARRB2/EGFR/EGR1/GNAI2/MAP2K1/RXRB/GATA3/MAPK1/MEF2A/CREB3L2/PLD1/MEF2C/ATF4/SP1/GNA11/PLCB2/RAF1/PDE4C/ATF6B/PRKCB/VDR/PDE4B/ATF2/MEF2D/ARRB1/ITPR3/PRKACA/BCL2/PDE4A/PRKACB/STK39/FGFR1/ARHGEF1/ARAF/ARHGEF11/ITPR1/ADCY9/PRKCA	5.72591537686047
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	69/2333	157/9376	1.76625050166402	ABCA1/LRP1/MAPK3/RAB5A/RXRA/DUSP2/CAMK2G/C1QB/LIPA/C1QA/SGK1/CD36/CPT1A/C1QC/HAVCR2/PTGER4/SIRPA/ALOX5/CASP1/GULP1/PTK2/ADAM10/CEBPB/TMEM30A/MAP2K1/PTGS2/IL10/STAB2/ANO6/MAPK1/DUSP4/RAB5B/PLA2G15/PTPN6/RAB14/CAMK2D/JAK2/MAPKAPK2/MERTK/NFATC3/SIRPB1/GPR132/SPHK1/SIGLEC10/HIF1A/CRK/NR1H2/BCAR1/VPS8/SIRT1/VPS39/DUSP7/PTGER2/TGFBRAP1/MAPK14/NR1H3/P2RY6/STAB1/VPS11/CASP7/EPOR/RAB7A/DNMT3A/TMEM30B/DUSP8/CPT1B/PLA2G6/NFATC1/SPHK2	5.57240731907639
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	73/2333	170/9376	1.72574569476312	CDKN1A/GADD45B/PIK3R1/TGFBR1/HMOX1/TGFB2/MAPK3/CDKN2A/GSTT1/TCF7L2/IGF2/EGFR/SMAD3/GADD45A/BRD7/RB1/NFE2L2/SOS1/SMAD4/MAP2K1/AKT3/PIK3CA/MAPK1/TCF7/PBRM1/TGFBR2/SMAD2/RAF1/FRAT1/MET/CSNK1A1/SMARCE1/PIK3CD/PRKCB/GSTO1/FZD1/SMARCD2/WNT2B/APC/TCF7L1/SMARCC2/DVL1/ARID1A/BCL2L1/PLCG2/ARID1B/RPS6KB1/SMARCD1/WNT6/DDB2/GAB1/PHF10/DPF1/FZD8/BAX/ARAF/KRAS/TXNRD3/AKT2/GADD45G/GSTA3/PIK3R2/FZD6/CDK6/TXNRD2/WNT5B/FZD7/FZD5/PRKCA/GSTM4/PLCG1/SMARCD3/PIK3R3	5.49588462509945
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	37/2333	69/9376	2.15504078222355	FCER1G/PIK3R1/MAPK3/VAV3/MAP2K3/ALOX5AP/LCP2/SYK/RAC2/ALOX5/MAPK8/PDPK1/SOS1/BTK/MAP2K1/AKT3/PIK3CA/TNF/MAPK1/VAV1/RAF1/PIK3CD/INPP5D/MAP2K7/LYN/MAPK14/PLCG2/LAT/MAP2K4/KRAS/PLA2G4C/VAV2/AKT2/PIK3R2/PRKCA/PLCG1/PIK3R3	5.5421869373463
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	46/2333	94/9376	1.96667609050533	NFKBIA/CXCL2/MAPK3/JUN/CXCL3/IL1B/FOSB/IL17RE/CCL20/MMP9/JUND/FOS/S100A8/S100A9/MAPK8/CEBPB/PTGS2/TNFAIP3/TNF/CCL7/MAPK6/MAPK1/NFKB1/CXCL10/TRADD/MAP3K7/TAB2/IL17D/RELA/IL17B/CCL2/MAPK14/FADD/IKBKG/TBK1/IKBKB/TAB3/IKBKE/TRAF6/CHUK/TRAF3/MAPK15/IL17RC/CXCL1/HSP90AA1/FOSL1	5.42111081769699
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	68/2333	158/9376	1.72963587926666	PIK3R1/MAPK3/LPIN2/RRAGC/SGK1/RHEB/ATP6V1G1/RRAGD/FNIP2/PDPK1/SOS1/ATP6V1B2/MAP2K1/AKT3/PIK3CA/TNF/FNIP1/MAPK1/RPS6KA3/CAB39/TNFRSF1A/LAMTOR4/SESN2/ATP6V1H/RAF1/ATP6V1C1/ULK2/PIK3CD/ATP6V1A/PRKCB/ATP6V1E1/FZD1/LAMTOR3/STK11/ATP6V1D/WNT2B/MAPKAP1/RICTOR/ULK1/TSC1/DVL1/LPIN1/TSC2/RPS6KB1/WNT6/IKBKB/RPS6KA2/FZD8/WDR59/PRKAA1/FLCN/KRAS/CHUK/AKT2/PIK3R2/RPTOR/FZD6/SLC38A9/ATP6V1E2/WDR24/WNT5B/DEPTOR/FZD7/RRAGB/FZD5/PRKCA/PIK3R3/DEPDC5	5.32329503510644
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	34/2333	62/9376	2.20389087842042	NOTCH2/TLE6/ATXN1/MAML2/CREBBP/TLE4/EP300/TLE3/NCSTN/DTX4/RBPJ/LFNG/TLE2/DTX3L/SPEN/MFNG/CIR1/PSEN1/NCOR2/ITCH/DVL1/NUMB/ATXN1L/RFNG/KAT2B/MAML1/CTBP2/NRARP/JAG2/PSEN2/NOTCH1/HES1/JAG1/PTCRA	5.47367509724292
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	37/2333	70/9376	2.12425448533464	PRKAG2/NFKBIA/RXRA/CD36/POMC/IRS2/CPT1A/ACSL5/ACSL3/MAPK8/RXRB/ACSL1/AKT3/TNF/NFKB1/NFKBIE/TNFRSF1A/TRADD/JAK2/TNFRSF1B/PPARA/STAT3/CAMKK2/STK11/RELA/IKBKG/IKBKB/NFKBIB/PRKAA1/PRKAB2/CHUK/AKT2/PCK2/PRKAB1/CPT1B/LEPR/ACACB	5.43370789861733
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	38/2333	73/9376	2.09200923028143	CDKN1A/GADD45B/FOXO3/PIK3R1/MAPK3/RXRA/CDKN2A/EGFR/GADD45A/PDPK1/RB1/SOS1/MAP2K1/RXRB/AKT3/PIK3CA/MAPK1/RAF1/MET/RASSF5/RASSF1/STAT3/PIK3CD/PRKCB/PLCG2/DDB2/STAT5A/BAX/ARAF/KRAS/JAK3/AKT2/GADD45G/PIK3R2/CDK6/PRKCA/PLCG1/PIK3R3	5.39064077838897
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	43/2333	87/9376	1.98633302294416	CDKN1A/GADD45B/PIK3R1/TGFBR1/TGFB2/MAPK3/JUN/RALGDS/EREG/TCF7L2/FOS/RAC2/EGFR/MAPK8/SMAD3/GADD45A/SOS1/SMAD4/MAP2K1/AKT3/PIK3CA/BCL2L11/MAPK1/TCF7/TGFBR2/SMAD2/RAF1/BBC3/AREG/PIK3CD/PMAIP1/APC/TCF7L1/RPS6KB1/BCL2/DDB2/BAX/ARAF/KRAS/AKT2/GADD45G/PIK3R2/PIK3R3	5.31940285498938
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	44/2333	90/9376	1.96477592036958	PRKAG2/CREB5/FOXO3/PIK3R1/FOXO1/ADCY7/IRS2/RHEB/RB1CC1/AKT3/PIK3CA/SESN1/NFKB1/CREB3L2/ATF4/SESN2/SESN3/ATF6B/PIK3CD/CAMKK2/SOD2/ATG13/STK11/RELA/ULK1/ATF2/TSC1/CAT/SIRT1/TSC2/PRKACA/RPS6KB1/PRKACB/EHMT2/BAX/PRKAA1/PRKAB2/KRAS/AKT2/PIK3R2/RPTOR/PRKAB1/ADCY9/PIK3R3	5.29294686160831
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	55/2333	122/9376	1.81178107411129	CSH2/CSH1/CREB5/PIK3R1/GNAQ/MAPK3/ITPR2/MAP2K3/JUNB/ADCY7/IRS2/IGFBP3/FOS/SOCS1/MAPK8/PTK2/SOS1/CREBBP/EP300/GNAI2/MAP2K1/AKT3/STAT1/PIK3CA/MAPK1/CREB3L2/ATF4/GNA11/PLCB2/RAF1/JAK2/ATF6B/CSHL1/STAT3/PIK3CD/PRKCB/ATF2/CRK/BCAR1/MAPK14/PLCG2/ITPR3/PRKACA/MAP2K4/PRKACB/MAP3K1/STAT5A/KRAS/AKT2/ITPR1/PIK3R2/ADCY9/PRKCA/PLCG1/PIK3R3	5.19419503895321
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	56/2333	125/9376	1.80044920702958	FCER1G/CTSD/ASAH1/PIK3R1/GNAQ/MAPK3/SGMS2/GNA13/PPP2CB/RAC2/MAPK8/CERS6/PDPK1/BID/GNAI2/MAP2K1/AKT3/MAP3K5/PIK3CA/TNF/PPP2R5E/MAPK1/NFKB1/PLD1/TNFRSF1A/TRADD/PLCB2/RAF1/CERS2/SPTLC2/PIK3CD/PRKCB/SMPD1/SPHK1/SPTSSA/SGPP1/PPP2R2D/S1PR4/RELA/ORMDL1/PPP2R3C/MAPK14/BCL2/ADORA3/NSMAF/PRKCE/BAX/KRAS/AKT2/PIK3R2/SGMS1/ACER2/PPP2R5B/PRKCA/SPHK2/PIK3R3	5.18511756875543
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	47/2333	100/9376	1.88886412344621	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/CSF2RA/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/CD36/IL1B/CD44/CD37/CD14/HLA-DRB5/CD9/FCGR1A/HLA-DQA2/CD4/CD59/CD22/ITGAM/IL4R/ITGA6/IL6R/HLA-DOA/TNF/CD33/CSF1R/ITGA3/IL7R/CSF3R/IL1R1/IL1R2/ITGA2/ITGA1/CD1D/TFRC/CD38/IL1A/ITGA4/CSF1/IL11/EPOR/ITGA5/MME/ANPEP	5.14303134104038
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	48/2333	103/9376	1.87286672021107	CXCL2/PIK3R1/GNAQ/TGFB2/ITGB2/RAB5A/CXCL3/IL1B/HSPB1/LAMA5/CD14/FN1/ITGAM/SERPINB6/PTK2/LAMC1/COL4A2/TLR4/GNA15/PIK3CA/TNF/IL10/PRDX1/COL4A1/TLR2/NFKB1/LAMA3/RAB5B/GNA11/PLCB2/IL1R1/IL1R2/PIK3CD/PRKCB/GNAL/LAMB3/RELA/LAMC2/CD1D/LAMB2/PRKACA/PRKACB/RAB7A/PIK3R2/SERPINB9/CXCL1/PRKCA/PIK3R3	5.12649550985739
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	50/2333	109/9376	1.8435136867521	PRKAG2/NFKBIA/CREB5/PIK3R1/MLXIP/CD36/SLC27A1/FOXO1/IRS2/CPT1A/PTPRF/MAPK8/PDPK1/AKT3/PIK3CA/TNF/RPS6KA3/NFKB1/CREB3L2/PPP1R3D/TNFRSF1A/GFPT1/PPARA/STAT3/SREBF1/PIK3CD/PRKCB/TBC1D4/RELA/NR1H2/PYGB/NR1H3/RPS6KB1/IKBKB/RPS6KA2/PRKCE/PRKAA1/PRKAB2/CRTC2/AKT2/OGT/PIK3R2/PCK2/PPARGC1B/PPP1R3E/PRKAB1/CPT1B/ACACB/GFPT2/PIK3R3	5.09800156733158
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	46/2333	99/9376	1.86734901522728	PIK3R1/MAPK3/JUN/RHEB/PDGFB/RALGDS/FOS/RAC2/EGFR/MAPK8/LYPLA1/WAS/PDPK1/SOS1/GPCPD1/MAP2K1/AKT3/PIK3CA/CHKB/MAPK1/DGKH/PLD1/SP1/RAF1/PIK3CD/PRKCB/HIF1A/WASF2/TSC1/TSC2/RPS6KB1/DGKA/SLC44A5/KRAS/PLA2G4C/AKT2/PDGFC/SLC22A4/PIK3R2/WASF1/PRKCA/SLC22A5/PIP5K1B/PLCG1/CHKA/PIK3R3	4.99311848840719
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	89/2333	232/9376	1.54171778234329	SSH2/RGCC/PIK3R1/MAPK3/ITGB2/VAV3/GSN/CXCR4/PDGFB/ITGAX/NCKAP1L/FN1/GNA13/ITGAM/RAC2/DIAPH2/TIAM1/EGFR/PTK2/SOS1/TMSB4X/ITGB1/ITGA6/ARHGEF7/MRAS/MAP2K1/BAIAP2/PAK2/AKT3/LPAR2/SCIN/PIK3CA/ITGB6/CHRM5/ITGA3/MAPK1/ITGAL/PPP1R12B/GIT1/GNG12/IQGAP2/VAV1/ARPC2/RAF1/LIMK1/PIP4K2A/PIK3CD/ITGAD/LIMK2/ITGA2/PIP4K2C/APC/WASF2/CRK/BCAR1/ITGA1/ITGB4/ARHGEF12/SLC9A1/CYFIP2/ARHGEF6/SSH3/ITGA4/ARHGAP35/ITGB7/BRK1/CYFIP1/SSH1/ARHGEF4/PIKFYVE/FGFR1/ARHGEF1/PIP4K2B/ARAF/ITGA5/KRAS/VAV2/AKT2/PDGFC/MSN/PIK3R2/FGD3/WASF1/FGF1/PIP5K1B/ACTR3C/FGFR2/MYL10/PIK3R3	4.80853895885089
Human Diseases	Infectious disease: viral	hsa05162	Measles	58/2333	136/9376	1.71392551877159	NFKBIA/CD46/PIK3R1/JUN/IL2RB/HSPA1B/IL1B/MX2/FOS/MAPK8/OAS2/BID/HSPA6/TLR4/IL2RG/AKT3/TNFAIP3/HSPA1A/STAT1/PIK3CA/TLR2/NFKB1/IFIH1/TRADD/CSNK2A2/TLR7/ADAR/MAP3K7/BBC3/STAT3/IFNAR1/PIK3CD/TAB2/STAT2/EIF2AK2/RELA/IL1A/BCL2L1/FADD/IKBKG/FCGR2B/BCL2/TBK1/IKBKB/NFKBIB/STAT5A/IKBKE/BAX/IRAK4/TRAF6/CHUK/TRAF3/JAK3/AKT2/MSN/PIK3R2/CDK6/PIK3R3	4.82670257135162
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	35/2333	70/9376	2.00942991855979	CDKN1A/PIK3R1/TGFB2/MAPK3/JUN/PDGFB/EPAS1/ARNT2/SOS1/CREBBP/EP300/MAP2K1/PAK2/AKT3/PIK3CA/MAPK1/VEGFA/RAF1/MET/RAP1A/PIK3CD/EGLN2/RAP1B/HIF1A/CRK/RAPGEF1/TFE3/GAB1/ARAF/FLCN/VHL/KRAS/AKT2/PIK3R2/PIK3R3	4.87874177343965
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	53/2333	122/9376	1.74589812596179	MED13L/PIK3R1/MAPK3/PLCD3/RXRA/NCOA1/NOTCH2/FOXO1/RHEB/MED13/PDPK1/CREBBP/EP300/ATP1B1/NCOA3/SLC16A10/MAP2K1/THRB/RXRB/AKT3/STAT1/MDM2/PIK3CA/MAPK1/PLCB2/RCAN1/RAF1/NCOR1/MED1/NCOA2/PIK3CD/PRKCB/TBC1D4/HIF1A/MED4/SLC9A1/TSC2/PLCG2/MED17/PRKACA/KAT2B/PRKACB/MED14/KRAS/AKT2/SIN3A/PIK3R2/NOTCH1/PFKFB2/ATP1A4/PRKCA/PLCG1/PIK3R3	4.77264187228892
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	31/2333	60/9376	2.07641091584512	PIK3R1/MAPK3/HSPB1/RAC2/PTK2/MAP2K1/PTGS2/AKT3/PIK3CA/MAPK1/VEGFA/MAPKAPK3/RAF1/MAPKAPK2/PPP3R1/PIK3CD/PRKCB/SPHK1/PPP3CB/MAPK14/PLCG2/PPP3CC/KRAS/PLA2G4C/AKT2/PPP3CA/PIK3R2/PRKCA/PLCG1/SPHK2/PIK3R3	4.81396736692948
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	59/2333	142/9376	1.66980796049335	BMPR2/DUSP1/SQSTM1/PIK3R1/HMOX1/JUN/IL1B/GSTT1/NCF2/PDGFB/ICAM1/MMP9/FOS/RAC2/MAPK8/PTK2/SDC2/NFE2L2/ARHGEF2/AKT3/MAP3K5/PIK3CA/TNF/KLF2/BMPR1B/MEF2A/NFKB1/VEGFA/MEF2C/TNFRSF1A/IL1R1/IL1R2/MAP3K7/PIK3CD/GSTO1/MAP2K7/RELA/IL1A/CCL2/CTSL/MAPK14/IKBKG/BCL2/MAP2K4/IKBKB/ACVR1/PRKAA1/CHUK/AKT2/GSTA3/PIK3R2/EDN1/MAP2K5/ACVR2A/TXN/HSP90AA1/GSTM4/NCF1/PIK3R3	4.6287497883144
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	36/2333	75/9376	1.9290527218174	SERPINE1/CDKN1A/GADD45B/CDKN2A/IGFBP3/GADD45A/BID/CD82/MDM2/SESN1/RRM2B/SESN2/PPP1R13L/ATM/SESN3/BBC3/PMAIP1/TNFRSF10A/ZNF385A/ZMAT3/SIAH1/CCNG2/TSC2/BCL2L1/MDM4/BCL2/GORAB/DDB2/BAX/TNFRSF10B/GADD45G/PPM1D/ATR/CDK6/AIFM2/STEAP3	4.64911547034938
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	52/2333	122/9376	1.71295665188704	NFKBIA/PIK3R1/MAPK3/JUN/VAV3/PTPRC/CD4/LCP2/FOS/PPP2CB/MAPK8/PDPK1/SOS1/MAP2K1/PAK2/AKT3/PIK3CA/TNF/IL10/PPP2R5E/MAPK1/NFKB1/VAV1/PTPN6/NFKBIE/RAF1/MAP3K7/NFATC3/PPP3R1/PIK3CD/MAP2K7/PPP2R2D/PPP3CB/RELA/PPP2R3C/MAPK14/DLG1/IKBKG/LAT/PPP3CC/IKBKB/NFKBIB/KRAS/CHUK/VAV2/AKT2/PPP3CA/PIK3R2/NFATC1/PPP2R5B/PLCG1/PIK3R3	4.56186528895678
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	63/2333	156/9376	1.62300108806753	CDKN1A/NFKBIA/PIK3R1/MAPK3/SCARB1/RXRA/CLDN19/YWHAG/CFLAR/MX2/PPP2CB/EGFR/OAS2/RB1/SOS1/BID/MAP2K1/AKT3/STAT1/PIK3CA/TNF/MAPK1/NFKB1/CXCL10/TNFRSF1A/TRADD/RAF1/CLDN23/LDLR/PPARA/PIAS1/STAT3/IFNAR1/PIK3CD/STAT2/EIF2AK2/PPP2R2D/RELA/RIPK1/CLDN9/NR1H3/FADD/IKBKG/TBK1/RSAD2/IKBKB/CLDN14/IKBKE/BAX/RNASEL/ARAF/TRAF6/KRAS/CHUK/TRAF3/AKT2/PIK3R2/CDK6/CLDN15/TICAM1/TLR3/PIK3R3/IFIT1	4.5159570955844
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	29/2333	56/9376	2.08119527279407	NFKBIA/CXCL2/ITGB2/CXCL3/HSPA1B/IL1B/PYCARD/CD14/IL18/EEF1A1/ITGAM/CASP1/HSPA6/TLR4/CLK4/HSPA1A/TNF/CLK1/TLR2/NFKB1/RAB1A/NFKB2/C3/TLR5/NAIP/RELA/RAB1B/CASP7/CXCL1	4.6704030249883
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	57/2333	138/9376	1.65996384576679	PRKAG2/PIK3R1/MAPK3/FBP1/FOXO1/IRS2/RHEB/PTPRF/SOCS1/MAPK8/PDPK1/SOS1/MAP2K1/INPPL1/AKT3/TRIP10/PIK3CA/PHKB/HK3/MAPK1/PPP1R3D/PRKAR1A/RAF1/FLOT2/PRKAR2A/RHOQ/SREBF1/PHKA2/PIK3CD/CBL/FLOT1/FASN/CRK/TSC1/PYGB/TSC2/RAPGEF1/PRKACA/RPS6KB1/PRKACB/IKBKB/PRKAA1/ARAF/PRKAB2/KRAS/AKT2/PDE3B/PIK3R2/PCK2/RPTOR/PPP1R3E/PRKAB1/ACACB/PRKAR1B/SORBS1/PHKA1/PIK3R3	4.49505357448798
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	55/2333	133/9376	1.6619345191096	HLA-B/TYROBP/FCER1G/HLA-A/TNFSF10/PIK3R1/MAPK3/ITGB2/VAV3/FCGR3A/IFNGR2/HCST/CD48/ICAM1/LCP2/SYK/RAC2/SOS1/BID/LAT2/MAP2K1/HLA-E/IFNGR1/PIK3CA/TNF/MAPK1/ITGAL/VAV1/PTPN6/SH3BP2/RAF1/PPP3R1/IFNAR1/PIK3CD/PRKCB/TNFRSF10A/PPP3CB/MICB/PTK2B/PLCG2/LAT/PPP3CC/ARAF/MICA/ICAM2/KRAS/VAV2/PPP3CA/TNFRSF10B/PIK3R2/FCGR3B/NFATC1/PRKCA/PLCG1/PIK3R3	4.42484983754794
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	46/2333	106/9376	1.74403351422171	CDKN1A/NFKBIA/CREB5/PIK3R1/MAPK3/FOXO1/PDGFB/MMP9/TCF7L2/EGFR/PDPK1/RB1/SOS1/CREBBP/EP300/MAP2K1/AKT3/MDM2/PIK3CA/MAPK1/TCF7/NFKB1/CREB3L2/ATF4/RAF1/IL1R2/PIK3CD/RELA/FOLR1/TCF7L1/PLAU/NKX3-1/FOLR2/IKBKG/BCL2/IKBKB/FGFR1/ARAF/KRAS/CHUK/AKT2/PDGFC/PIK3R2/HSP90AA1/FGFR2/PIK3R3	4.4337349499318
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	43/2333	98/9376	1.76337727547084	PIK3R1/ITPR2/PLCD3/INPPL1/IPMK/PIK3CA/INPP5B/DGKH/PI4KA/PLCB2/PIP4K2A/CDIPT/PIK3CD/PRKCB/IP6K2/PI4K2A/INPP5D/PIP4K2C/MTMR1/PI4KB/SYNJ2/PLCG2/IP6K1/PIK3C2A/ITPR3/OCRL/MTMR3/ITPKC/PIKFYVE/DGKA/PIK3C3/SACM1L/PIP4K2B/MTMR6/ITPK1/ITPR1/PIK3R2/MTM1/INPP1/PRKCA/PIP5K1B/PLCG1/PIK3R3	4.37209152345567
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	124/2333	362/9376	1.37662602155478	SPP1/CSH2/CDKN1A/CSH1/CREB5/FOXO3/PIK3R1/MAPK3/RXRA/IL2RB/YWHAG/SGK1/LAMA5/RHEB/PDGFB/EREG/OSM/SYK/PIK3AP1/IGF2/FN1/FLT1/PKN1/PPP2CB/EGFR/IL4R/PDPK1/PTK2/RBL2/SOS1/ITGB1/LAMC1/ITGA6/IL6R/MAP2K1/COL4A2/TLR4/IL2RG/OSMR/AKT3/LPAR2/MDM2/PIK3CA/SGK3/ITGB6/COL4A1/CSF1R/ITGA3/PPP2R5E/BCL2L11/MAPK1/PIK3R5/TLR2/GNG12/NFKB1/LAMA3/IL7R/CSF3R/CREB3L2/VEGFA/ERBB3/ATF4/MCL1/RAF1/JAK2/MET/ATF6B/THBS3/AREG/CSHL1/IFNAR1/PIK3CD/GNGT2/STK11/PKN2/LAMB3/ITGA2/PPP2R2D/RELA/ATF2/PRLR/TSC1/PPP2R3C/LAMC2/ITGA1/ITGB4/GNG10/LAMB2/LPAR6/TSC2/BCL2L1/ITGA4/IKBKG/ITGB7/RPS6KB1/CSF1/BCL2/EPOR/IKBKB/FGFR1/PRKAA1/ITGA5/KRAS/CHUK/CRTC2/JAK3/AKT2/PDGFC/PIK3R2/PCK2/RPTOR/CDK6/ANGPT2/EFNA5/PPP2R5B/GNG7/HSP90AA1/FGF1/SGK2/PRKCA/FGFR2/VWF/NTF4/PIK3R3	4.20600703210735
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	36/2333	78/9376	1.85485838636289	PLCD3/INPPL1/IPMK/PIK3CA/INPP5B/PI4KA/PLCB2/PIP4K2A/CDIPT/PIK3CD/IP6K2/PI4K2A/INPP5D/PIP4K2C/MTMR1/PI4KB/SYNJ2/PLCG2/IP6K1/PIK3C2A/OCRL/MTMR3/ITPKC/PIKFYVE/PIK3C3/SACM1L/PIP4K2B/MTMR6/ITPK1/FIG4/INPP5K/MTM1/INPP1/PIP5KL1/PIP5K1B/PLCG1	4.36325776661623
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	36/2333	78/9376	1.85485838636289	SERPING1/MAPK3/ITGB2/JUN/C1QB/C1QA/IL1B/LY96/PYCARD/C1QC/CD14/C2/FOS/ITGAM/IRF1/CASP1/MAPK8/ITGB1/GNAI2/TLR4/TNF/IL10/IRF8/MAPK1/NFKB1/NLRP3/C3/RELA/C4BPB/IL1A/MAPK14/CASP7/IRAK4/ITGA5/TRAF6/TICAM1	4.36325776661623
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	19/2333	32/9376	2.38619802828976	BIRC3/MAPK8/BID/BIRC7/XIAP/BCL2L11/TNFRSF1A/BIRC6/BBC3/PMAIP1/BECN1/BCL2L1/BIRC2/FADD/BCL2/CASP7/BAX/BOK/DIABLO	4.52062012865573
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	43/2333	99/9376	1.74556538379942	CDKN1A/PIK3R1/MAPK3/JUN/NOTCH2/CDKN2A/ADCY7/HBEGF/MMP9/FOS/EGFR/MAPK8/PTK2/RB1/SOS1/NCOA3/MAP2K1/AKT3/MDM2/PIK3CA/MAPK1/SP1/RAF1/NCOR1/MED1/PIK3CD/CARM1/MAPK14/PRKACA/RPS6KB1/BCL2/PRKACB/BAX/JAG2/ARAF/KRAS/AKT2/PIK3R2/NOTCH1/ADCY9/JAG1/ESR2/PIK3R3	4.29203957900357
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	65/2333	168/9376	1.55491600840936	CSH2/CDKN1A/CSH1/CSF2RB/IL6ST/CSF2RA/PIM1/PIK3R1/IL2RB/IFNGR2/PDGFB/STAT4/OSM/SOCS1/IL13RA1/EGFR/STAT6/IL4R/SOS1/IL27RA/CREBBP/EP300/IL6R/IL2RG/OSMR/IFNGR1/AKT3/STAT1/PIK3CA/IL10/FHL1/IL7R/CSF3R/PTPN6/MCL1/RAF1/JAK2/PIAS1/STAM/CSHL1/STAT3/IFNAR1/PIK3CD/STAT2/CLCF1/IL10RB/IL27/PRLR/IL10RA/BCL2L1/IL12RB1/BCL2/IL11/EPOR/STAT5A/SOCS5/JAK3/AKT2/PIK3R2/CTF1/CISH/IL15RA/LEPR/PIAS3/PIK3R3	4.17698968347236
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	30/2333	62/9376	1.94460959860625	PRKAG2/FOXO3/PIK3R1/EIF4EBP2/HSPA1B/FOXO1/ADCY7/IRS2/HSPA6/AKT3/HSPA1A/PIK3CA/PIK3CD/SOD2/SOD1/CAT/SIRT1/PRKACA/RPS6KB1/PRKACB/PRKAA1/PRKAB2/KRAS/AKT2/PIK3R2/RPTOR/PRKAB1/ADCY9/CRYAB/PIK3R3	4.29481286816599
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	26/2333	51/9376	2.04883050519822	TJP1/ATP6V0D1/TJP2/ATP6V0E1/ATP6V1G1/ATP6AP1/ATP6V1B2/ATP6V0A1/ATP6V1H/ATP6V1C1/ATP6V0B/ATP6V1A/ATP6V1E1/ATP6V1D/SLC12A2/PLCG2/PRKACA/KDELR3/PRKACB/KCNQ1/ATP6V0A2/ATP6V1E2/ATP6V0E2/ADCY9/PRKCA/PLCG1	4.3224516247664
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	104/2333	298/9376	1.40255511094106	CSH2/GDF15/CSH1/CSF2RB/INHA/IL6ST/TNFSF10/CSF2RA/BMPR2/CCL3/CXCL2/TGFBR1/TGFB2/CXCR4/IL1RAP/IL2RB/IFNGR2/CXCL3/EBI3/IL1B/CXCL16/IL1RN/TNFSF13B/IL18/IL17RE/CCL20/CD4/XCR1/TNFRSF14/CCL18/OSM/IL13RA1/TNFRSF12A/CCL5/CXCR6/IL4R/ACKR3/CCL4/CD40/IL27RA/IL6R/IL2RG/OSMR/IFNGR1/TNF/BMPR1B/IL10/TNFSF12/CSF1R/CCL7/CXCL9/CCR1/IL7R/CSF3R/TGFBR2/CXCL10/TNFRSF1A/IL1R1/IL1R2/RELL2/TNFRSF1B/CSHL1/IFNAR1/TNFRSF10A/IL17D/TNFSF14/CLCF1/IL10RB/IL27/PRLR/IL17B/IL16/IL10RA/TNFRSF25/IL1A/CCL2/RELT/IL12RB1/ACVR1B/CSF1/IL11/EPOR/TNFRSF10D/ACVR1/EDA2R/RELL1/CCL3L3/TNFRSF10C/TNFRSF10B/CTF1/IL17RC/IL15RA/ACVR2A/CXCR2/LTB/TNFRSF11A/TNFSF9/IL34/LEPR/CXCL1/TNFRSF18/CCL28/IL18R1/XCL1	4.06445716727935
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	50/2333	122/9376	1.64707370373754	PRKAG2/CREB5/FOXO3/PIK3R1/CD36/FBP1/FOXO1/IRS2/RHEB/CPT1A/PPP2CB/PDPK1/PFKFB3/AKT3/PIK3CA/TBC1D1/PPP2R5E/CREB3L2/CAB39/MLYCD/RAB14/MAP3K7/SREBF1/PIK3CD/CAMKK2/STK11/FASN/PPP2R2D/ULK1/TSC1/PPP2R3C/SIRT1/RAB11B/TSC2/RPS6KB1/RAB2A/PRKAA1/PRKAB2/CRTC2/AKT2/PIK3R2/PCK2/RPTOR/PRKAB1/PFKFB2/CPT1B/LEPR/PPP2R5B/ACACB/PIK3R3	4.14031212229249
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	36/2333	80/9376	1.80848692670381	FOXO3/PIK3R1/MAPK3/PDGFB/EGFR/SOS1/IL6R/MAP2K1/AKT3/PIK3CA/BCL2L11/MAPK1/VEGFA/ERBB3/RAF1/JAK2/MET/STAT3/PIK3CD/PRKCB/NF1/BCL2L1/PLCG2/RPS6KB1/BCL2/GAB1/BAX/ARAF/KRAS/AKT2/PDGFC/PIK3R2/PRKCA/PLCG1/FGFR2/PIK3R3	4.17959403888714
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	38/2333	86/9376	1.77577527686679	CDKN1A/PIK3R1/MAPK3/JUN/CAMK2G/HBEGF/EREG/EGFR/MAPK8/PTK2/SOS1/MAP2K1/PAK2/AKT3/PIK3CA/ABL2/MAPK1/ERBB3/RAF1/CAMK2D/AREG/PIK3CD/PRKCB/CBL/MAP2K7/CRK/PLCG2/RPS6KB1/MAP2K4/GAB1/STAT5A/ARAF/KRAS/AKT2/PIK3R2/PRKCA/PLCG1/PIK3R3	4.15950324080555
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	55/2333	140/9376	1.57883779315412	SPP1/SERPINE1/PRKAG2/TGFBR1/GNAQ/MAPK3/ITPR2/MAP1LC3B/ADCY7/GNA13/SMAD3/EGR1/SMAD4/GNAI2/MRAS/MAP2K1/AKT3/KLF2/MAPK1/MEF2A/PIK3R5/GNG12/MEF2C/SMAD2/PLCB2/RAF1/SPHK1/GNGT2/BECN1/GNG10/MEF2D/SLC9A1/ITPR3/PRKACA/HDAC5/RPS6KB1/PRKACB/PRKCE/PIK3C3/PRKAA1/PRKAB2/KRAS/AKT2/ITPR1/PDE3B/PRKAB1/HDAC4/MAP1LC3B2/GNG7/ADCY9/JAG1/SLC8A1/NRF1/AGTR1/SPHK2	3.97139512353134
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	42/2333	100/9376	1.68792113159023	IL6ST/TNFSF10/CCL3/CXCL2/CXCR4/IL2RB/CXCL3/IL18/CCL20/XCR1/TNFRSF14/CCL18/CCL5/ACKR3/CCL4/IL6R/IL2RG/TNF/IL10/CSF1R/CCL7/CXCL9/CCR1/CXCL10/TNFRSF1A/TNFRSF1B/TNFRSF10A/TNFSF14/IL10RB/IL10RA/CCL2/CSF1/TNFRSF10D/CCL3L3/TNFRSF10C/TNFRSF10B/CXCR2/IL34/CXCL1/CCL28/IL18R1/XCL1	3.9803608297468
Human Diseases	Cancer: specific types	hsa05214	Glioma	34/2333	76/9376	1.79791097976403	CDKN1A/GADD45B/PIK3R1/MAPK3/CAMK2G/CDKN2A/PDGFB/EGFR/GADD45A/RB1/SOS1/MAP2K1/AKT3/MDM2/PIK3CA/MAPK1/CAMK1/RAF1/CAMK2D/CAMK1D/PIK3CD/PRKCB/PLCG2/DDB2/BAX/ARAF/KRAS/AKT2/GADD45G/PIK3R2/CDK6/PRKCA/PLCG1/PIK3R3	4.01961007916673
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	47/2333	116/9376	1.6283311409019	ESAM/PIK3R1/JAM2/ITGB2/CLDN19/VAV3/CXCR4/NCF2/ICAM1/CYBB/MMP9/ITGAM/RAC2/PTK2/ITGB1/CD99L2/GNAI2/PIK3CA/ITGAL/VAV1/SIPA1/CLDN23/RASSF5/CD99/RAP1A/PIK3CD/PRKCB/RAP1B/BCAR1/PTK2B/CLDN9/MAPK14/PLCG2/ITGA4/ARHGAP35/CLDN14/NCF4/VAV2/MSN/RAPGEF3/PIK3R2/CLDN15/PRKCA/PLCG1/MYL10/NCF1/PIK3R3	3.91900889425065
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	51/2333	130/9376	1.57662962840845	NFKBIA/CREB5/PIK3R1/TGFBR1/MAPK3/JUN/ADCY7/MMP9/FOS/ARRB2/EGFR/MAPK8/SOS1/GNAI2/MAP2K1/COL4A2/AKT3/GNA15/EDNRB/PIK3CA/COL4A1/MAPK1/GNG12/NFKB1/CREB3L2/VEGFA/TGFBR2/ATF4/SMAD2/PLCB2/RAF1/ATF6B/PIK3CD/GNGT2/MAP2K7/RELA/ATF2/GNG10/MAPK14/ARRB1/PRKACA/MAP2K4/PRKACB/KRAS/AKT2/PIK3R2/EDN1/GNG7/ADCY9/PRKCA/PIK3R3	3.81027085284137
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	74/2333	205/9376	1.45071038022853	HLA-B/CDKN1A/NFKBIA/HLA-A/IL6ST/CREB5/ATP6V0D1/REL/PIK3R1/MAPK3/JUN/GSN/YWHAG/CDKN2A/HLA-F/SYK/RBL2/RB1/VAC14/DDB1/CREBBP/EP300/UBR4/HLA-E/MDM2/SCIN/PIK3CA/RBPJ/CHD4/MAPK1/NFKB1/CREB3L2/USP7/ATF4/NFKB2/TRADD/MAPKAPK2/ATF6B/EGR2/SP100/EGR3/STAT3/C3/PIK3CD/UBE3A/CDKN2B/PMAIP1/HDAC7/EIF2AK2/RELA/ATF2/GTF2E2/LYN/TBP/DLG1/IKBKG/PRKACA/HDAC5/KAT2B/PRKACB/TRAF1/STAT5A/BAX/KRAS/GTF2H1/TRAF3/JAK3/POLB/HDAC6/PIK3R2/RASA2/CDK6/HDAC4/PIK3R3	3.75517609458424
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	33/2333	75/9376	1.76829832833262	CDKN1A/PIK3R1/MAPK3/CDKN2A/GSTT1/BIRC3/PDPK1/BID/XIAP/AKT3/MAP3K5/MDM2/PIK3CA/MAPK1/ATM/BBC3/ERCC1/PIK3CD/GSTO1/PMAIP1/ATP7A/BCL2L1/BIRC2/SLC31A1/FADD/BCL2/BAX/AKT2/GSTA3/PIK3R2/POLH/GSTM4/PIK3R3	3.84467701370857
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	73/2333	203/9376	1.44520575423512	SPP1/PIK3R1/MAPK3/JUN/VAV3/LAMA5/PDGFB/PARVG/FN1/FLT1/BIRC3/RAC2/EGFR/MAPK8/CAPN2/PDPK1/PTK2/SOS1/ITGB1/LAMC1/ITGA6/MAP2K1/COL4A2/XIAP/PAK2/TLN2/AKT3/PIK3CA/ITGB6/COL4A1/ITGA3/MAPK1/PPP1R12B/LAMA3/VEGFA/VAV1/RAF1/MET/RAP1A/EMP1/THBS3/PIK3CD/PRKCB/FLNB/RASGRF1/LAMB3/ITGA2/RAP1B/CRK/LAMC2/BCAR1/ITGA1/ITGB4/LAMB2/BIRC2/RAPGEF1/ITGA4/ARHGAP35/ITGB7/BCL2/ZYX/PARVB/ITGA5/VAV2/AKT2/PDGFC/PIK3R2/EMP2/PRKCA/PIP5K1B/VWF/MYL10/PIK3R3	3.69077231723359
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	44/2333	110/9376	1.60754393484784	SERPINE1/CDKN1A/PIK3R1/HMOX1/MAPK3/IFNGR2/CAMK2G/CYBB/EPAS1/FLT1/EGFR/CREBBP/EP300/IL6R/MAP2K1/TLR4/PFKFB3/IFNGR1/AKT3/PIK3CA/HK3/MAPK1/NFKB1/VEGFA/CAMK2D/STAT3/PIK3CD/PRKCB/EGLN2/RELA/HIF1A/TFRC/PLCG2/RPS6KB1/BCL2/VHL/AKT2/PIK3R2/EDN1/ENO3/ANGPT2/PRKCA/PLCG1/PIK3R3	3.68885893425049
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	62/2333	168/9376	1.48315065417509	TNFSF10/GLUL/SQSTM1/IFNGR2/CAMK2G/CFLAR/IL1B/PYCARD/CYBB/STAT4/FTL/FTH1/BIRC3/CASP1/MAPK8/STAT6/CAPN2/BID/TLR4/XIAP/IFNGR1/TNFAIP3/STAT1/CHMP3/TNF/CYLD/CHMP1A/CHMP1B/VPS4B/NLRP3/TNFRSF1A/TRADD/CAMK2D/CHMP4C/JAK2/STAT3/IFNAR1/TNFRSF10A/STAT2/SMPD1/TRPM7/EIF2AK2/VPS4A/PYGB/MLKL/RIPK1/IL1A/BIRC2/FADD/RBCK1/BCL2/SPATA2L/STAT5A/BAX/PLA2G4C/JAK3/TNFRSF10B/USP21/RIPK3/TICAM1/TLR3/HSP90AA1	3.63679415888014
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	27/2333	59/9376	1.8391392474954	CDKN1A/GADD45B/FOXO3/PIK3R1/MAPK3/TCF7L2/EGFR/GADD45A/PDPK1/SOS1/MAP2K1/AKT3/PIK3CA/MAPK1/TCF7/RAF1/PIK3CD/APC/TCF7L1/DDB2/BAX/ARAF/KRAS/AKT2/GADD45G/PIK3R2/PIK3R3	3.72122693226696
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	21/2333	42/9376	2.00942991855979	HMOX1/MAP1LC3B/ACSL5/CYBB/FTL/SAT1/ACSL3/FTH1/SLC39A8/PRNP/ACSL1/GPX4/TFRC/SLC39A14/SLC11A2/PCBP1/GCLC/LPCAT3/ATG7/MAP1LC3B2/STEAP3	3.77338468975425
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	31/2333	71/9376	1.75471345000996	FOXO3/PIK3R1/MAPK3/FOS/SOCS1/IRF1/MAPK8/SOS1/MAP2K1/AKT3/STAT1/PIK3CA/MAPK1/NFKB1/RAF1/JAK2/STAT3/PIK3CD/RELA/PRLR/MAPK14/STAT5A/KRAS/TH/SOCS5/AKT2/PIK3R2/CISH/TNFRSF11A/ESR2/PIK3R3	3.67381462588261
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	82/2333	238/9376	1.38464918757902	RASGRF2/RASA1/REL/PIK3R1/MAPK3/RAB5A/ETS2/PDGFB/RALGDS/IGF2/FLT1/RAC2/TIAM1/EGFR/MAPK8/SOS1/SHOC2/MRAS/MAP2K1/RASAL2/PAK2/AKT3/PIK3CA/ABL2/CSF1R/MAPK1/RASGRP3/GNG12/NFKB1/RAB5B/VEGFA/PLD1/KSR1/RAF1/MET/RGL2/RASSF5/RAP1A/RASSF1/PIK3CD/PRKCB/RASGRF1/GNGT2/RAP1B/RELA/GNG10/RALGAPB/NF1/BCL2L1/PLCG2/IKBKG/PRKACA/CSF1/LAT/TBK1/RASA4/EXOC2/PRKACB/IKBKB/GAB1/FGFR1/RASA3/KRAS/PLA2G4C/CHUK/AKT2/PDGFC/PIK3R2/RASA2/ANGPT2/EFNA5/PLA2G6/RALGAPA1/RGL1/GNG7/FGF1/PRKCA/PLCG1/SYNGAP1/FGFR2/NTF4/PIK3R3	3.45932913498558
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	52/2333	139/9376	1.50345835633251	CREB5/CTSD/PIK3R1/GNAQ/MAPK3/ITPR2/JUN/NCOA1/HSPA1B/POMC/ADCY7/KRT14/HBEGF/MMP9/FOS/EGFR/SOS1/HSPA6/NCOA3/GNAI2/MAP2K1/AKT3/HSPA1A/PIK3CA/RARA/MAPK1/KRT15/CREB3L2/ATF4/SP1/PLCB2/RAF1/ATF6B/NCOA2/PIK3CD/ATF2/ITPR3/PRKACA/FKBP5/BCL2/PRKACB/KRAS/AKT2/KRT16/ITPR1/PIK3R2/KRT9/ADCY9/HSP90AA1/ESR2/KRT17/PIK3R3	3.44167332122843
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	29/2333	67/9376	1.7395064966637	GNAQ/MAPK3/ITPR2/CAMK2G/CREBBP/EP300/MAP2K1/MAPK1/RPS6KA3/ATF4/PLCB2/RAF1/CAMK2D/RAP1A/PPP3R1/PRKCB/RAP1B/PPP3CB/ITPR3/PRKACA/PPP3CC/PRKACB/RPS6KA2/ARAF/KRAS/PPP3CA/ITPR1/RAPGEF3/PRKCA	3.49616598612849
NA	NA	hsa04518	Integrin signaling	56/2333	154/9376	1.4614035771344	SPP1/FBN1/PIK3R1/ITGB2/LIMS2/LAMA5/PDGFB/ICAM1/FERMT3/ITGAX/PARVG/FN1/FLT1/ITGAM/RAC2/EGFR/PTK2/ITGB1/LAMC1/ITGA6/COL4A2/TLN2/AKT3/PIK3CA/ITGB6/COL4A1/ITGA3/ITGAL/LAMA3/VEGFA/MET/THBS3/C3/PIK3CD/ITGAD/FLNB/LAMB3/ITGA2/LAMC2/ITGA1/ITGB4/LAMB2/ARHGEF6/ITGA4/ITGB7/PARVB/LIMS1/ICAM2/ITGA5/AKT2/PDGFC/FERMT1/PIK3R2/ICAM4/VWF/PIK3R3	3.32271369939596
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	62/2333	174/9376	1.43200752816905	MAN1A1/MBTPS1/SEC31A/OS9/HSPA1B/DNAJB1/HERPUD1/MAPK8/CAPN2/AMFR/SEC24D/PPP1R15A/NFE2L2/HSPA6/SEC24A/EDEM3/HSPA1A/DNAJB2/MAP3K5/UBE2D1/DERL3/UBE2G2/ATF4/SEC63/SEL1L/SYVN1/UGGT2/UBXN6/SEC23A/RRBP1/ATF6B/BCAP29/FBXO6/DNAJC5B/UBQLN4/MAP2K7/DNAJC5/RNF185/SEC24C/DDIT3/UBQLN1/ERN1/UBE2D4/UBE2J1/BCL2/UBQLN2/UBE4B/TRAM1/EIF2AK3/SEC24B/HSPH1/BAX/NPLOC4/UBE2D3/SKP1/SEC62/MAN1C1/YOD1/TXNDC5/HSP90AA1/CRYAB/FBXO2	3.31046490342864
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	63/2333	178/9376	1.42240544796929	SFRP1/JUN/TLE6/CAMK2G/BAMBI/ANKRD6/TCF7L2/CTNND2/NOTUM/RAC2/MAPK8/SMAD3/CREBBP/TLE4/EP300/SMAD4/TLE3/MMP7/TCF7/PORCN/TLE2/DAAM1/PLCB2/CSNK2A2/CAMK2D/MAP3K7/FRAT1/CSNK1A1/TBL1XR1/CELSR1/FBXW11/NFATC3/PPP3R1/RYK/PSEN1/PRKCB/FZD1/WNT2B/APC/PPP3CB/TCF7L1/SIAH1/DVL1/SIRT1/PRKACA/ROR1/PPP3CC/WNT6/PRKACB/CTBP2/FZD8/SKP1/PPP3CA/BTRC/NLK/FZD6/WNT5B/FZD7/NFATC1/CELSR2/FZD5/PRKCA/FOSL1	3.27459031345767
Human Diseases	Immune disease	hsa05330	Allograft rejection	19/2333	39/9376	1.95790607449416	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DRB5/HLA-DQA2/HLA-F/CD86/CD40/HLA-E/HLA-DOA/TNF/IL10	3.44997314769727
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	56/2333	155/9376	1.45197516695934	CDKN1A/CREB5/GNAQ/MAPK3/ITPR2/SCARB1/CAMK2G/CDKN2A/POMC/ADCY7/AHR/TCF7L2/EGFR/RB1/GNAI2/MAP2K1/MAPK1/TCF7/CREB3L2/NCEH1/ATF4/SP1/GNA11/PLCB2/CAMK2D/LDLR/KMT2A/RAP1A/USP8/ATF6B/CRH/CDKN2B/FZD1/WNT2B/APC/RAP1B/ATF2/TCF7L1/DVL1/ITPR3/PRKACA/WNT6/PRKACB/FZD8/KMT2D/ITPR1/ARMC5/FZD6/CDK6/WNT5B/FZD7/ADCY9/RASD1/FZD5/AGTR1/WDR5B	3.26554426700057
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	41/2333	107/9376	1.53993694693367	PRKAG2/CREB5/GNAQ/ITPR2/SIK1/CAMK2G/FBP1/FOXO1/CPT1A/CREBBP/EP300/AKT3/PHKB/CREB3L2/ATF4/PLCB2/CAMK2D/PPP3R1/PPARA/PHKA2/PPP3CB/ATF2/PYGB/SIRT1/SIK2/ITPR3/PRKACA/PPP3CC/PRKACB/PRKAA1/PRKAB2/CRTC2/AKT2/PPP3CA/ITPR1/PDE3B/PCK2/PRKAB1/CPT1B/ACACB/PHKA1	3.23282843709212
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	32/2333	79/9376	1.62789259225097	SLC6A2/ATP6V0D1/VAMP2/SLC1A3/CLTB/SLC17A8/ATP6V0E1/ATP6V1G1/AP2B1/AP2A2/ATP6V1B2/ATP6V0A1/NAPA/STX3/CLTC/ATP6V1H/ATP6V1C1/ATP6V0B/SLC6A4/ATP6V1A/ATP6V1E1/ATP6V1D/DNM2/CACNA1A/SLC1A6/STXBP1/ATP6V0A2/ATP6V1E2/SYT1/AP2S1/ATP6V0E2/STX1A	3.22545994432458
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	31/2333	76/9376	1.6392717756672	OLR1/ACOX1/FABP7/RXRA/ANGPTL4/CD36/SLC27A1/CPT1A/ACSL5/CYP27A1/LPL/ACSL3/FABP4/PDPK1/RXRB/ACSL1/GK/FABP3/UBC/PPARA/NR1H3/ME1/ME3/CPT2/ACADM/ACOX3/PCK2/PLIN5/CPT1B/FABP5/SORBS1	3.22043854260362
Human Diseases	Cancer: specific types	hsa05218	Melanoma	30/2333	73/9376	1.65158623443271	CDKN1A/GADD45B/PIK3R1/MAPK3/CDKN2A/PDGFB/EGFR/GADD45A/RB1/MITF/MAP2K1/AKT3/MDM2/PIK3CA/MAPK1/RAF1/MET/PIK3CD/DDB2/FGFR1/BAX/ARAF/KRAS/AKT2/PDGFC/GADD45G/PIK3R2/CDK6/FGF1/PIK3R3	3.21651798223779
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	53/2333	148/9376	1.43918629302256	CDKN1A/GADD45B/PIK3R1/MAPK3/JUN/NCOA1/NOTCH2/TCF7L2/FOS/EGFR/GADD45A/RB1/SOS1/NCOA3/MAP2K1/AKT3/PIK3CA/MAPK1/TCF7/NFKB2/SP1/RAF1/FRAT1/CSNK1A1/PIK3CD/FZD1/WNT2B/APC/TCF7L1/DVL1/RPS6KB1/WNT6/DDB2/FZD8/FGFR1/BAX/JAG2/ARAF/KRAS/AKT2/GADD45G/PIK3R2/NOTCH1/HES1/FZD6/CDK6/WNT5B/FZD7/JAG1/FGF1/FZD5/ESR2/PIK3R3	3.09948833007546
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	16/2333	32/9376	2.00942991855979	GABARAPL2/GABARAP/GABARAPL1/PPP2CB/ULK2/ATG13/BECN1/ATG2B/ATG7/PIK3C3/WIPI1/ATG4D/ATG16L1/ATG9B/RPTOR/ATG2A	3.29191725509717
Human Diseases	Immune disease	hsa05310	Asthma	16/2333	32/9376	2.00942991855979	PRG2/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/FCER1G/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DRB5/HLA-DQA2/CD40/HLA-DOA/TNF/IL10	3.29191725509717
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	36/2333	93/9376	1.555687678885	MAP3K2/GNAQ/MAPK3/ITPR2/JUN/MAP2K3/CAMK2G/ADCY7/HBEGF/EGFR/MAPK8/EGR1/SOS1/MAP2K1/MAPK1/PLD1/ATF4/GNA11/PLCB2/RAF1/CAMK2D/MAP3K3/PRKCB/MAP2K7/PTK2B/MAPK14/ITPR3/PRKACA/MAP2K4/PRKACB/MAP3K1/KRAS/PLA2G4C/ITPR1/ADCY9/PRKCA	3.09950420475312
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	11/2333	19/9376	2.32670832675345	HEXB/GNS/IDS/HEXA/NAGLU/HGSNAT/GALNS/GUSB/GLB1/SGSH/HYAL4	3.3315635662687
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	53/2333	149/9376	1.42952732461301	FCER1G/PIK3R1/MAPK3/ADCY7/RHEB/PDGFB/RALGDS/SYK/GNA13/EGFR/CYTH1/SOS1/MRAS/MAP2K1/AKT3/LPAR2/PIK3CA/CYTH2/MAPK1/DGKH/PIK3R5/AGPAT1/CYTH3/CYTH4/PLD1/PLCB2/RAF1/PIK3CD/SPHK1/DNM2/TSC1/PTK2B/LPAR6/TSC2/PLCG2/GAB1/DGKA/AGPAT3/KRAS/PLA2G4C/AKT2/PDGFC/AGPAT4/RAPGEF3/PIK3R2/CXCR2/ADCY9/AGTR1/PRKCA/PIP5K1B/PLCG1/SPHK2/PIK3R3	3.04171020067045
Organismal Systems	Immune system	hsa04611	Platelet activation	46/2333	126/9376	1.46720279767858	FCER1G/SNAP23/PIK3R1/GNAQ/MAPK3/ITPR2/ADCY7/VAMP8/FERMT3/FCGR2A/LCP2/SYK/GNA13/TBXAS1/BTK/ITGB1/GNAI2/TLN2/AKT3/PIK3CA/MAPK1/PIK3R5/PTGS1/PLCB2/RAP1A/APBB1IP/PIK3CD/ITGA2/RAP1B/ARHGEF12/LYN/MAPK14/PLCG2/ARHGAP35/ITPR3/PRKACA/PRKG1/PRKACB/ARHGEF1/PLA2G4C/AKT2/ITPR1/PIK3R2/ADCY9/VWF/PIK3R3	3.03867326137156
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	20/2333	44/9376	1.82675447141799	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/IL1B/HLA-DRB5/HLA-DQA2/HLA-F/CD86/HLA-E/HLA-DOA/TNF/IL1A/ICA1	3.16358632086353
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	41/2333	110/9376	1.49793866656276	FBN1/NOG/LTBP1/BMPR2/TGFBR1/TGFB2/MAPK3/SKIL/BAMBI/HAMP/PPP2CB/SMAD3/EMP3/CREBBP/EP300/SMAD4/TNF/BMPR1B/MAPK1/TGFBR2/SMAD2/SP1/SMURF2/ID2/SMAD7/NCOR1/RGMB/CDKN2B/LEMD3/TFRC/FST/SMAD1/ACVR1B/RPS6KB1/SMURF1/ACVR1/HFE/SKP1/SKI/SIN3A/ACVR2A	3.02336241628162
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	53/2333	150/9376	1.41999714244892	CDKN1A/GADD45B/PIK3R1/TGFBR1/TGFB2/MAPK3/RXRA/TCF7L2/EGFR/SMAD3/GADD45A/RB1/SOS1/SMAD4/MAP2K1/RXRB/AKT3/PIK3CA/MAPK1/TCF7/TGFBR2/SMAD2/RAF1/FRAT1/MET/CSNK1A1/PIK3CD/CDKN2B/FZD1/WNT2B/APC/TCF7L1/DVL1/RPS6KB1/BCL2/WNT6/DDB2/GAB1/FZD8/JUP/BAX/ARAF/KRAS/AKT2/GADD45G/PIK3R2/FZD6/WNT5B/FZD7/FGF1/FZD5/FGFR2/PIK3R3	2.98434758248985
NA	NA	hsa03272	Virion - Hepatitis viruses	21/2333	48/9376	1.75825117873982	HSPG2/LAMP2/SCARB1/CLDN19/CD9/IST1/LAMP1/EGFR/CHMP1A/CHMP1B/PDCD6IP/VPS4B/CLDN23/LDLR/TGOLN2/DPP4/TSG101/VPS4A/CLDN9/CLDN14/CLDN15	3.03112333171321
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	14/2333	28/9376	2.00942991855979	ATP6V0D1/ATP6V0E1/ATP6V1G1/ATP6V1B2/ATP6V0A1/ATP6V1C1/ATP6V1A/ATP6V1E1/ATP6V1D/SLC12A7/ATP6V0A2/ATP6V1E2/ATP6V0E2/CA2	3.07864774191605
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	37/2333	99/9376	1.50199812094368	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DMA/ITGB2/HLA-DQA1/FCGR3A/C1QB/C1QA/HLA-DMB/C5AR1/KRT14/C1QC/ICAM1/HLA-DRB5/FCGR1A/HLA-DQA2/FPR3/C2/FCGR2A/C3AR1/ITGAM/PTAFR/FPR1/HLA-DOA/IL10/ITGAL/KRT15/SELPLG/C3/FCGR2B/KRT16/FCGR3B/KRT9/KRT17	2.88988176019634
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	16/2333	34/9376	1.89122815864451	PRKAG2/CRY1/FBXW11/CLOCK/PER2/NR1D2/BHLHE41/DBP/PRKAA1/PRKAB2/SKP1/PER1/BTRC/PRKAB1/PER3/CRY2	2.99621235260777
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	62/2333	184/9376	1.3541810320729	SSH2/BMPR2/RASA1/RHOD/PIK3R1/MAPK3/CXCR4/CAMK2G/EPHB2/NTN4/DPYSL2/SEMA5A/SEMA3C/PLXNC1/RAC2/PDPK1/PTK2/ITGB1/EFNB2/GNAI2/PAK2/PARD6G/PLXNB2/PIK3CA/BMPR1B/EFNB1/MAPK1/NRP1/SEMA4A/RAF1/CAMK2D/MET/LIMK1/NFATC3/PPP3R1/RYK/PIK3CD/LIMK2/PPP3CB/SRGAP2/ARHGEF12/SSH3/PLCG2/PPP3CC/SSH1/PARD6B/SRGAP1/KRAS/PPP3CA/PIK3R2/CDK5/PLXNB1/PTCH1/EFNA5/WNT5B/SEMA6D/SRGAP3/PLXNA3/SEMA4D/PRKCA/PLCG1/PIK3R3	2.79250118572106
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	55/2333	160/9376	1.38148306900986	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/ESAM/JAM2/HLA-DQB1/HLA-DMA/PVR/ITGB2/HLA-DQA1/CLDN19/MAG/HLA-DMB/PDCD1LG2/PTPRC/ICAM1/PTPRF/HLA-DRB5/ALCAM/HLA-DQA2/HLA-F/CD4/CD86/CD22/ITGAM/CD58/SDC2/CD40/ITGB1/GLG1/ITGA6/CD99L2/CD274/HLA-E/HLA-DOA/SIGLEC1/SPN/ITGAL/SELPLG/CLDN23/CD99/NLGN4X/CLDN9/ITGA4/ITGB7/CADM1/CLDN14/ICAM2/ICOSLG/PTPRS/CLDN15/PTPRM	2.80109726538627
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	70/2333	212/9376	1.32698202169043	PIK3R1/GNAQ/MAPK3/ITGB2/VAV3/MAP2K3/EVL/ADCY7/PDGFB/RALGDS/LCP2/FLT1/ITGAM/RAC2/TIAM1/EGFR/ITGB1/FPR1/GNAI2/MRAS/MAP2K1/DOCK4/TLN2/AKT3/PARD6G/LPAR2/PIK3CA/RAPGEF2/CSF1R/MAPK1/RASGRP3/ITGAL/VEGFA/VAV1/PLCB2/RAF1/SIPA1/MET/RASSF5/RAP1A/APBB1IP/PIK3CD/PRKCB/ADORA2B/RAP1B/CRK/BCAR1/MAPK14/RAPGEF1/CSF1/LAT/PARD6B/FGFR1/KRAS/PRKD2/VAV2/AKT2/PDGFC/RAPGEF3/PIK3R2/ANGPT2/EFNA5/RAPGEF6/SIPA1L3/ADCY9/FGF1/PRKCA/PLCG1/FGFR2/PIK3R3	2.771490717133
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	50/2333	144/9376	1.3954374434443	KLF4/IL6ST/BMPR2/ZFHX3/PIK3R1/MAPK3/JARID2/SKIL/SMAD3/KAT6A/BMI1/SMAD4/MAP2K1/AKT3/PIK3CA/BMPR1B/MAPK1/TCF7/SMAD2/RAF1/JAK2/ID2/STAT3/PIK3CD/FZD1/WNT2B/APC/DVL1/MAPK14/SMAD1/ACVR1B/ISL1/RIF1/WNT6/FZD8/FGFR1/DUSP9/ACVR1/KRAS/JAK3/AKT2/PIK3R2/FZD6/ACVR2A/PCGF5/WNT5B/FZD7/FZD5/FGFR2/PIK3R3	2.75217028335445
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	10/2333	18/9376	2.23269990951088	HEXB/HEXA/AGA/GLB1/MAN2B2/FUCA1/NEU1/MANBA/ENGASE/MAN2B1	3.01277195258841
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	21/2333	50/9376	1.68792113159023	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/CXCR4/HLA-DMB/TNFSF13B/HLA-DRB5/HLA-DQA2/CD86/CD40/HLA-DOA/IL10/ITGA4/ITGB7/ICOSLG/IL15RA/CCL28	2.80698511949012
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	28/2333	72/9376	1.56288993665762	NFKBIA/MAPK8/TNF/CYLD/TRIM25/NFKB1/CXCL10/IFIH1/TRADD/ADAR/MAP3K7/ZNFX1/NLRX1/RELA/RIPK1/OTUD5/MAPK14/FADD/IKBKG/TBK1/RNF125/IKBKB/MAP3K1/NFKBIB/IKBKE/TRAF6/CHUK/TRAF3	2.75942786271
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	18/2333	41/9376	1.76437748946714	CDKN1A/MAPK3/DAPK1/CDKN2A/HBEGF/MMP9/EGFR/RB1/MAP2K1/MDM2/MAPK1/VEGFA/RAF1/RPS6KA5/RASSF1/DAPK3/ARAF/KRAS	2.82297361769335
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	11/2333	21/9376	2.10511705753883	DSE/CHPF2/CSGALNACT2/XYLT1/CHST11/CHST13/CHPF/CHST14/CHST12/CHST7/CHST15	2.91783142397833
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	41/2333	115/9376	1.43281089845133	CREB5/PIK3R1/GNAQ/MAPK3/ITPR2/CAMK2G/ADCY7/KCNJ2/FOS/GNAI2/MAP2K1/AKT3/PIK3CA/CHRM5/MAPK1/PIK3R5/GNG12/CREB3L2/ATF4/GNA11/PLCB2/CAMK2D/JAK2/PIK3CD/PRKCB/GNGT2/GNG10/CACNA1A/ITPR3/PRKACA/BCL2/PRKACB/KRAS/KCNQ1/AKT2/ITPR1/PIK3R2/GNG7/ADCY9/PRKCA/PIK3R3	2.68770951947941
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	31/2333	82/9376	1.51932506037448	HLA-DRA/HLA-B/CD74/HLA-DPA1/HLA-DRB1/HLA-DPB1/TAPBP/CTSS/HLA-A/LGMN/HLA-DQB1/CTSB/HLA-DMA/HLA-DQA1/TAPBPL/HSPA1B/HLA-DMB/HLA-DRB5/HLA-DQA2/HLA-F/CD4/HSPA6/IFI30/B2M/HLA-E/HLA-DOA/HSPA1A/TNF/CIITA/CTSL/HSP90AA1	2.71837292385343
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	28/2333	73/9376	1.54148048547053	BST2/CXCR4/ELL2/SAMHD1/CD4/MX2/CREBBP/EP300/SUPT5H/MDFIC/SERINC3/PDCD6IP/VPS4B/ELL/HGS/AFF4/APOBEC3A/TSG101/APOBEC3B/RANBP2/VPS4A/APOBEC3G/KAT2B/CCNT1/NUP153/CCNT2/APOBEC3C/SERINC5	2.6729872832
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	27/2333	70/9376	1.55013165146041	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/ITGB2/HLA-DQA1/HLA-DMB/ICAM1/HLA-DRB5/HLA-DQA2/HLA-F/CD86/RAC2/CD40/BID/HLA-E/HLA-DOA/ABL2/DAG1/ITGAL/SNTB1/EIF4G2/EIF4G3	2.65887727272894
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	34/2333	93/9376	1.46926058561361	TJP1/TGFBR1/MAPK3/PTPRF/TCF7L2/RAC2/EGFR/SMAD3/WAS/CREBBP/EP300/SMAD4/BAIAP2/MAPK1/TCF7/TGFBR2/PTPN6/SMURF2/CSNK2A2/MAP3K7/MET/RAP1A/RAP1B/WASF2/TCF7L1/SMURF1/FGFR1/LMO7/NLK/PTPRJ/PTPRM/WASF1/SORBS1/MYL10	2.61743280173628
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	19/2333	45/9376	1.69685193122827	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/IL1B/HLA-DRB5/HLA-DQA2/HLA-F/CD86/HLA-E/HLA-DOA/TNF/IL1A	2.69678816467684
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	37/2333	104/9376	1.42978667282139	PLD3/LPIN2/SGMS2/LYPLA1/LPCAT2/GDPD5/LPCAT1/MBOAT7/GPCPD1/CHKB/GPAM/DGKH/AGPAT1/PCYT2/PLA2G15/PLD1/CDIPT/LCAT/PLD4/ETNK1/LPIN1/CEPT1/LPCAT3/SAMD8/DGKA/AGPAT3/GPD2/PGS1/PLA2G4C/AGPAT4/SGMS1/MBOAT1/PISD/PLB1/PLA2G6/GPD1L/CHKA	2.53657125123051
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	22/2333	55/9376	1.60754393484784	ASAH1/HEXB/HEXA/B4GALT5/UGCG/SGMS2/PSAP/CERS6/ACER3/GLB1/ARSA/CERS2/SPTLC2/NEU1/SMPD1/SPHK1/SGPP1/CERK/SAMD8/SGMS1/ACER2/SPHK2	2.60071009707385
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	36/2333	101/9376	1.43246489243867	GNAQ/MAPK3/CAMK2G/POMC/ADCY7/TCF7L2/CREBBP/EP300/MITF/GNAI2/MAP2K1/EDNRB/MAPK1/TCF7/CREB3L2/PLCB2/RAF1/CAMK2D/PRKCB/FZD1/WNT2B/TCF7L1/DVL1/PRKACA/WNT6/PRKACB/FZD8/KRAS/EDN1/FZD6/WNT5B/FZD7/MC1R/ADCY9/FZD5/PRKCA	2.51488857723237
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	25/2333	65/9376	1.54571532196907	SPP1/PIK3R1/GNAQ/MAPK3/ITPR2/ARRB2/KISS1/MAP2K1/AKT3/PIK3CA/MAPK1/GNA11/PLCB2/RAF1/PIK3CD/PRKCB/ARRB1/ITPR3/KRAS/AKT2/ITPR1/PIK3R2/PRKCA/ESR2/PIK3R3	2.54090732933733
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2333	37/9376	1.73788533497063	CDKN1A/GADD45B/MAPK3/RXRA/TCF7L2/GADD45A/MAP2K1/RXRB/MAPK1/TCF7/TCF7L1/DDB2/TFG/BAX/KRAS/GADD45G	2.58823506594079
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	30/2333	83/9376	1.45259994112756	NFKBIA/IL1B/SAMHD1/PYCARD/IFI16/IL18/CASP1/CCL5/CCL4/NFKB1/NLRP3/CXCL10/TREX1/POLR3D/ADAR/ZCCHC3/RELA/MLKL/RIPK1/PCBP1/FADD/IKBKG/CASP7/TBK1/IKBKB/NFKBIB/IKBKE/CHUK/POLR3A/RIPK3	2.38363489241108
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	16/2333	38/9376	1.69215151036614	PIK3R1/MAPK3/SGK1/PDPK1/ATP1B1/PIK3CA/MAPK1/PIK3CD/PRKCB/NEDD4L/KRAS/PIK3R2/NR3C2/ATP1A4/PRKCA/PIK3R3	2.46053868703456
NA	NA	hsa04517	IgSF CAM signaling	91/2333	299/9376	1.22313125477553	ESAM/TJP1/RASA1/PIK3R1/JAM2/MAPK3/TUBB2A/PVR/ITGB2/VAV3/IL1RAP/TJP2/MAG/FOXO1/CD84/CD48/ICAM1/PTPRF/ITGAX/CD86/CABLES1/LCP2/MBP/EPB41L3/ITGAM/DOK2/MAPK8/PDPK1/PTK2/TUBA1A/ITGB1/MAP2K1/BAIAP2/PAK2/AKT3/PARD6G/SLAMF7/PIK3CA/RAPGEF2/TRIO/MAPK1/ITGAL/DOK1/NRP1/GIT1/VAV1/PTPN6/ARPC2/CSK/CRTAM/RAP1A/PIK3CD/PRKCB/NLGN4X/INPP5D/PPFIA1/NRP2/RAP1B/SRGAP2/BCAR1/TUBA4A/LYN/MAPK14/PLCG2/ITGA4/PARD6B/CADM1/SRGAP1/FGFR1/GLDN/ICAM2/ITGA5/TRAF6/PMP22/VAV2/AKT2/MSN/LMO7/PIK3R2/PTPRS/RAPGEF6/GRIP1/CASK/CABLES2/SRGAP3/PLXNA3/PRKCA/PLCG1/ACTR3C/SORBS1/PIK3R3	2.25677882127252
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	8/2333	15/9376	2.14339191313045	HEXB/HEXA/ST3GAL5/GLB1/B3GALT4/ST8SIA1/ST3GAL2/ST6GALNAC6	2.55060840547345
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	68/2333	217/9376	1.25936621624024	KLF4/CREB5/PIK3R1/MAPK3/RXRA/JUN/NOTCH2/GSTT1/ADCY7/BCL6/AHR/FOS/ARRB2/EGFR/RB1/SOS1/GNAI2/MAP2K1/RXRB/XIAP/AKT3/PIK3CA/MIR29A/MAPK1/RPS6KA3/NFKB1/CREB3L2/VEGFA/ATF4/RAF1/JAK2/ATF6B/PPARA/STAT3/PIK3CD/PRKCB/GSTO1/VDR/RELA/KPNA6/ATF2/KPNA3/CACNA1A/KLF5/ARRB1/PRKACA/RPS6KB1/BCL2/PRKACB/RPS6KA2/STAT5A/IKBKE/KRAS/AKT2/EPHX2/GSTA3/PIK3R2/CYP1B1/PAQR8/EPHX3/ADCY9/JAG1/HSP90AA1/PRKCA/GSTM4/ESR2/KPNA5/PIK3R3	2.22476122768024
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	51/2333	157/9376	1.30548950122993	SERPINE1/BMPR2/TGFBR1/TGFB2/ITGB2/YWHAG/LLGL2/TCF7L2/TEAD1/BIRC3/PPP2CB/SMAD3/SMAD4/WWTR1/PARD6G/BMPR1B/AMOT/TCF7/TGFBR2/LATS1/SMAD2/BBC3/FBXW11/ID2/SMAD7/AREG/RASSF1/FZD1/WNT2B/APC/PPP2R2D/TCF7L1/DVL1/STK3/BIRC2/DLG1/SMAD1/WNT6/PARD6B/NF2/FZD8/YAP1/BTRC/LIMD1/FZD6/WTIP/WNT5B/FZD7/FGF1/FZD5/AJUBA	2.2216128131177
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	14/2333	33/9376	1.70497083999013	SNAP23/VAMP2/STX4/VAMP8/STX11/VAMP7/STX7/STX3/STX5/STX16/VAMP5/STX18/STX17/STX1A	2.33479692344812
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	54/2333	170/9376	1.27657900708505	PRKAG2/TJP1/JAM2/AMOTL2/CLDN19/JUN/TJP2/LLGL2/PPP2CB/TIAM1/MAPK8/WAS/TUBA1A/MICALL2/ITGB1/ARHGEF2/PARD6G/MAP3K5/AMOT/RAPGEF2/RUNX1/SYMPK/SYNPO/HCLS1/ARPC2/CLDN23/RAP1A/YBX3/STK11/MAP2K7/AMOTL1/PPP2R2D/CD1D/TUBA4A/CLDN9/DLG1/PRKACA/PRKACB/PARD6B/NF2/NEDD4L/MAP3K1/CLDN14/PRKCE/PRKAA1/TJAP1/PRKAB2/MSN/CGNL1/PRKAB1/ARHGEF18/RAPGEF6/CLDN15/ACTR3C	2.0944613569635
Organismal Systems	Nervous system	hsa04730	Long-term depression	22/2333	60/9376	1.47358194027718	GNAQ/MAPK3/ITPR2/GNA13/PPP2CB/GNAI2/MAP2K1/MAPK1/GNA11/PLCB2/RAF1/CRH/PRKCB/LYN/CACNA1A/ITPR3/PRKG1/ARAF/KRAS/PLA2G4C/ITPR1/PRKCA	2.11797183817256
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	46/2333	144/9376	1.28380244796876	PIK3R1/GNAQ/ITPR2/ATXN1/VLDLR/MAPK8/PPIF/RB1CC1/AKT3/MAP3K5/PIK3CA/ATXN2/RBPJ/PUM2/BEAN1/ATXN2L/SP1/PLCB2/PUM1/ULK2/PIK3CD/PRKCB/ATG13/ULK1/BECN1/KAT5/ATXN1L/CACNA1A/TBP/ERN1/ITPR3/ATG2B/SLC1A6/CIC/ATG14/PIK3C3/WIPI1/AKT2/PSMA6/ITPR1/PIK3R2/KCNC3/ATG2A/PRKCA/PSMA8/PIK3R3	1.97521169679744
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	33/2333	99/9376	1.33961994570653	PIK3R1/GNAQ/ITPR2/MAP2K3/IL1RAP/CAMK2G/IL1B/ADCY7/PTGER4/MAPK8/PIK3CA/PLCB2/IL1R1/CAMK2D/PIK3CD/PRKCB/PTGER2/MAPK14/PLCG2/ITPR3/PRKACA/PRKACB/PRKCE/PLA2G4C/ITPR1/PIK3R2/HRH1/PLA2G6/ADCY9/PRKCA/PLCG1/TRPV2/PIK3R3	1.95510988099151
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	12/2333	29/9376	1.66297648432535	RASSF4/TEAD1/RASSF2/WWTR1/LATS1/RASSF1/STK3/NF2/YAP1/LIMD1/WTIP/AJUBA	2.05790425590289
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	30/2333	89/9376	1.35467185520885	TJP1/MAP3K2/GNAQ/MAPK3/TUBB2A/ITPR2/ADCY7/PDGFB/EGFR/TUBA1A/SOS1/GNAI2/GJA1/MAP2K1/MAPK1/GNA11/PLCB2/RAF1/PRKCB/TUBA4A/ITPR3/PRKACA/PRKG1/PRKACB/KRAS/PDGFC/ITPR1/MAP2K5/ADCY9/PRKCA	1.93485387053752
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	19/2333	52/9376	1.46842955587062	APOE/ABCA1/MYLIP/LRP1/SCARB1/ANGPTL4/LIPA/CD36/APOC1/CYP27A1/LPL/SOAT1/NPC2/TSPO/APOC2/NCEH1/NPC1/LDLR/LCAT	1.94943604617859
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	21/2333	59/9376	1.43044163694087	MGLL/PIK3R1/ADCY7/IRS2/PTGER3/FABP4/GNAI2/PTGS2/AKT3/PIK3CA/PTGS1/PIK3CD/PNPLA2/PRKACA/PRKG1/PRKACB/AKT2/PDE3B/PIK3R2/ADCY9/PIK3R3	1.90882623704502
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	48/2333	154/9376	1.25263163754377	CDKN1A/PRKAG2/GNAQ/MAPK3/ITPR2/JUN/RGS2/CAMK2G/ADCY7/KCNJ2/FOS/EGFR/GNAI2/MAP2K1/PTGS2/MAPK1/PPP1R12B/PIK3R5/MEF2C/CAMK1/PLCB2/RCAN1/RAF1/CAMK2D/CAMK1D/NFATC3/PPP3R1/PRKCB/CAMKK2/CACNA2D4/PPP3CB/CD38/ITPR3/PRKACA/PPP3CC/PRKACB/PRKAA1/PRKAB2/KRAS/PLA2G4C/CACNA2D3/PPP3CA/ITPR1/MAP2K5/PRKAB1/NFATC1/ADCY9/PRKCA	1.81928065703532
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	42/2333	133/9376	1.26911363277461	CREB5/GNAQ/ITPR2/CAMK2G/MAOA/FOS/PPP2CB/ARRB2/MAPK8/GNAI2/AKT3/PPP2R5E/GNG12/CREB3L2/ATF4/PLCB2/CAMK2D/COMT/ATF6B/CLOCK/PRKCB/GNAL/GNGT2/PPP2R2D/PPP3CB/ATF2/PPP2R3C/GNG10/CACNA1A/MAPK14/ARRB1/ITPR3/PRKACA/PPP3CC/PRKACB/TH/AKT2/PPP3CA/ITPR1/PPP2R5B/GNG7/PRKCA	1.79895047000485
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	18/2333	50/9376	1.44678954136305	LRP1/TGFB2/ITGB2/CD36/IL1B/ICAM1/IL18/SDC2/CD40/TLR4/TNF/IL10/ITGAL/TLR2/MET/THBS3/HBB/CCL2	1.82307467609085
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	8/2333	18/9376	1.78615992760871	ACSL5/ACSL3/ACSL1/FASN/MECR/HSD17B8/OLAH/ACACB	1.92140890242155
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	16/2333	44/9376	1.4614035771344	CREB5/VAMP2/RAB5A/STX4/ARHGDIB/DYNC1LI2/CREB3L2/RAB5B/DCTN4/DCTN1/DCTN6/RAB11B/PRKACA/PRKACB/ADCY9/AQP3	1.76556655631546
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	20/2333	59/9376	1.36232536851511	UPP1/ENTPD1/NT5E/DCTD/TK2/DPYD/ENTPD4/NME3/CMPK1/RRM2B/NT5C2/CDA/NME4/CANT1/CMPK2/ENTPD8/AK9/NME6/UCK2/ENTPD5	1.60675945450803
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	7/2333	16/9376	1.75825117873982	HEXB/HEXA/NAGA/ST8SIA1/GBGT1/ST3GAL2/A4GALT	1.74702582334526
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	31/2333	98/9376	1.27127198929293	CREB5/GNAQ/ITPR2/SCARB1/CAMK2G/NR4A2/POMC/ADCY7/DAGLB/ATP1B1/CREB3L2/ATF4/CAMK1/GNA11/PLCB2/CAMK2D/LDLR/CAMK1D/ATF6B/PRKCB/ATF2/ITPR3/PRKACA/PRKACB/PRKCE/PRKD2/ITPR1/ATP1A4/ADCY9/AGTR1/PRKCA	1.55365636762905
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	17/2333	49/9376	1.39429831083741	GALNT7/GALNT6/PLOD3/GALNT3/LFNG/POFUT2/MFNG/B4GALT2/RFNG/FUT11/GALNT11/OGT/POMT2/GALNT12/ST3GAL3/POMT1/GALNT10	1.59263454521831
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	69/2333	238/9376	1.16513163345064	RPS4Y1/NFKBIA/IL6ST/PIK3R1/MAPK3/JUN/C1QB/C1QA/IL1B/C5AR1/C1QC/CYBB/HBEGF/C2/FCGR2A/MX2/C3AR1/SYK/FOS/CASP1/EGFR/MAPK8/OAS2/IL6R/TLR4/STAT1/PIK3CA/TNF/MAPK1/NRP1/TLR2/NFKB1/NLRP3/CXCL10/TNFRSF1A/IFIH1/TLR7/ADAR/MAP3K7/STAT3/C3/IFNAR1/PIK3CD/PRKCB/TAB2/STAT2/TLR8/EIF2AK2/RELA/RPS27L/CCL2/MAPK14/PLCG2/IKBKG/TBK1/IKBKB/NFKBIB/IKBKE/IRAK4/TRAF6/CHUK/TRAF3/PIK3R2/TLR3/AGTR1/PRKCA/PLCG1/VWF/PIK3R3	1.48510562130382
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	19/2333	56/9376	1.36354173045129	ARRB2/GLI3/SMURF2/SPOPL/CSNK1A1/FBXW11/SPOP/IQCE/CSNK1G2/ARRB1/PRKACA/MEGF8/BCL2/PRKACB/SMURF1/MGRN1/BTRC/PTCH1/HHAT	1.57037904283602
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	21/2333	63/9376	1.33961994570653	PIPOX/PRDM2/ASH1L/PLOD3/PLOD2/KMT2C/SMYD3/KMT2E/KMT2A/SETDB2/PHYKPL/DOT1L/SETD1B/KMT2B/EHMT2/SETD1A/KMT2D/ALDH3A2/EZH1/TMLHE/PRDM16	1.55662078404837
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	21/2333	63/9376	1.33961994570653	CDKN1A/GADD45B/TCF7L2/GADD45A/TCF7/GLI3/FZD1/WNT2B/APC/TCF7L1/DVL1/WNT6/DDB2/FZD8/BAX/GADD45G/FZD6/PTCH1/WNT5B/FZD7/FZD5	1.55662078404837
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	8/2333	20/9376	1.60754393484784	GMDS/NPL/UGDH/GNE/CYB5R1/CYB5R2/CYB5R4/NANP	1.56535103340769
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	16/2333	47/9376	1.36812249774284	PIK3R1/MAPK3/IRS2/SOCS1/MAPK8/PIK3CA/TNF/HK3/MAPK1/PIK3CD/CACNA1A/IKBKB/PRKCE/PIK3R2/MAFA/PIK3R3	1.4560889494002
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	18/2333	54/9376	1.33961994570653	HLA-DRA/HLA-B/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DRB5/HLA-DQA2/HLA-F/CD86/CD40/HLA-E/HLA-DOA/IL10	1.44045495627116
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	11/2333	30/9376	1.47358194027718	IL1B/ABCC3/TNF/NFKB1/MTHFR/RELA/FOLR1/FOLR2/IKBKG/IKBKB/CHUK	1.49522667026813
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	21/2333	65/9376	1.29840087045402	CREB5/GNAQ/ITPR2/SCARB1/POMC/ADCY7/CREB3L2/NCEH1/ATF4/SP1/GNA11/PLCB2/LDLR/ATF6B/ATF2/ITPR3/PRKACA/PRKACB/ITPR1/ADCY9/AGTR1	1.38938550613067
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	22/2333	69/9376	1.28137560024103	CREB5/JUN/CAMK2G/MAOA/FOSB/FOS/CREB3L2/ATF4/CAMK2D/PPP3R1/ATF6B/PRKCB/PPP3CB/ATF2/SIRT1/PRKACA/PPP3CC/PRKACB/TH/PPP3CA/STX1A/PRKCA	1.35011351992417
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2333	38/9376	1.37487310217249	QPRT/NT5E/NMNAT2/NAMPT/NT5C2/SIRT1/CD38/SIRT6/NNT/SIRT5/NADSYN1/SIRT2/NMNAT1	1.33264141854742
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	48/2333	166/9376	1.16207995290205	CREB5/GNAQ/MAPK3/ITPR2/GTF2I/RGS2/ADCY7/IRS2/GNA13/PPIF/ATP1B1/GNAI2/MAP2K1/AKT3/EDNRB/MAPK1/MEF2A/PIK3R5/CREB3L2/MEF2C/ATF4/GNA11/PLCB2/RAF1/NFATC3/PPP3R1/ATF6B/KCNMA1/PPP3CB/ATF2/MEF2D/ITPR3/KCNMB1/PRKG1/PPP3CC/ADORA3/PRKCE/AKT2/PPP3CA/ITPR1/PDE3B/ATP1A4/NFATC1/ADCY9/SLC8A1/NPPB/AGTR1/KCNMB4	1.21260036364548
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/2333	85/9376	1.22929830311893	UPP1/ENTPD1/NT5E/GDA/DCTD/TK2/ENTPD4/NME3/CMPK1/RRM2B/LACC1/AMPD3/AMPD2/NT5C2/CDA/NME4/CANT1/CMPK2/ENTPD8/AK9/NME6/UCK2/HPRT1/AK3/ENTPD5/GMPR	1.22220269506539
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	24/2333	78/9376	1.23657225757526	PIK3R1/CLTB/FN1/PTK2/ITGB1/PIK3CA/HCLS1/MAD2L2/CLTC/ARPC2/MET/PIK3CD/CBL/DNM2/WASF2/CRK/BCAR1/GAB1/ITGA5/PIK3R2/ELMO2/WASF1/ACTR3C/PIK3R3	1.20748156267487
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	27/2333	89/9376	1.21920466968797	SPP1/HSPG2/CD36/CD44/LAMA5/FN1/ITGB1/LAMC1/ITGA6/COL4A2/ITGB6/COL4A1/DAG1/ITGA3/LAMA3/THBS3/AGRN/LAMB3/ITGA2/LAMC2/ITGA1/ITGB4/LAMB2/ITGA4/ITGB7/ITGA5/VWF	1.19583495943288
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	17/2333	53/9376	1.28906824964213	GNAQ/CLTB/AP2B1/AP2A2/ATP1B1/CLTC/PLCB2/PRKCB/VDR/DNM2/PRKACA/PRKACB/AP2S1/ATP1A4/ADCY9/SLC8A1/PRKCA	1.21457587024831
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	23/2333	75/9376	1.23245035005001	CREB5/GNAQ/ITPR2/ADCY7/ATP1B1/CREB3L2/ATF4/PLCB2/ATF6B/ASGR1/PRKCB/GPX3/ATF2/ITPR3/PRKACA/PRKACB/GSR/ITPR1/TTF2/ATP1A4/ADCY9/PRKCA/GPX1	1.16321549157252
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	34/2333	116/9376	1.17794167639712	GLUL/HOMER3/GNAQ/MAPK3/ITPR2/SLC1A3/ADCY7/SLC17A8/GNAI2/MAPK1/GNG12/PLD1/SLC38A1/PLCB2/PPP3R1/HOMER1/PRKCB/SLC38A2/GNGT2/PPP3CB/GNG10/CACNA1A/ITPR3/PRKACA/PPP3CC/PRKACB/SLC1A6/PLA2G4C/PPP3CA/ITPR1/GNG7/ADCY9/PRKCA/SHANK2	1.1098526987811
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	55/2333	195/9376	1.13352456944399	PIK3R1/MAPK3/ITGB2/FCGR3A/C5AR1/NCF2/CYBB/FCGR1A/FPR3/AQP9/FCGR2A/SYK/ITGAM/RAC2/CASP1/PPIF/FPR1/MAP2K1/TLR4/AKT3/PIK3CA/MAPK1/ITGAL/TLR2/SIGLEC9/NFKB1/PLCB2/SELPLG/RAF1/TLR7/MAP3K7/C3/PIK3CD/PRKCB/HDAC7/TLR8/RELA/ELANE/MAPK14/PLCG2/HDAC5/ATG7/NCF4/AKT2/HDAC6/PIK3R2/CLEC7A/CLCN5/FCGR3B/HDAC4/PRKCA/PLCG1/VWF/NCF1/PIK3R3	1.08442035690424
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	25/2333	83/9376	1.21049995093964	PIPOX/ACOX1/ACSL5/ACSL3/ABCD1/ACSL1/PRDX1/FAR2/AGXT/NUDT19/DECR2/MLYCD/SOD2/PEX11B/SOD1/ABCD4/CAT/GSTK1/CRAT/PEX3/EPHX2/ACOX3/DHRS4/PEX26/PEX12	1.10860603883534
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	12/2333	38/9376	1.26911363277461	HEXB/HEXA/RENBP/UGDH/GNE/HK3/GNPDA1/GFPT1/CHIT1/UXS1/PMM2/GFPT2	0.956675662385036
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	15/2333	49/9376	1.23026321544477	CREB5/JUN/MAOA/FOSB/GNAI2/NFKB1/CREB3L2/ATF4/ATF6B/RELA/ATF2/PRKACA/PRKACB/TH/CDK5	0.930070308015119
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	33/2333	117/9376	1.13352456944399	MBD3/SMARCA1/BAZ2B/MORF4L2/BRD7/RSF1/CHD4/PBRM1/EPC1/SRCAP/GATAD2B/EPC2/SMARCE1/PHF6/CHD3/SMARCD2/SMARCC2/KAT5/INO80D/ARID1A/BAZ2A/ARID1B/MBD2/ZNHIT1/SMARCD1/ING3/PHF10/DPF1/INO80E/SS18L1/BCL7C/BRD8/SMARCD3	0.836442783258207
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/2333	17/9376	1.41842111898338	LAMP2/LAMP1/DAG1/PCDH1/NRP2/TFRC	0.99377369535371
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/2333	57/9376	1.19860731984268	ACOX1/CPT1A/ACSL5/ACSL3/ACSL1/ACAA2/PPT1/ELOVL5/FASN/ELOVL4/ACADVL/CPT2/ACADM/ACOX3/MECR/CPT1B/HSD17B8	0.865589911607928
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	103/2333	388/9376	1.06686227634876	APOE/PIK3R1/GNAQ/LRP1/MAPK3/TUBB2A/ITPR2/IL1B/SLC39A11/IRS2/SLC39A13/CYBB/LPL/SLC39A8/MAPK8/CAPN2/TUBA1A/PPIF/RB1CC1/RTN4/BACE2/ADAM10/BID/MAP2K1/PTGS2/NCSTN/AKT3/MAP3K5/PIK3CA/TNF/CHRM5/MAPK1/NFKB1/ATF4/MT-ND4L/TNFRSF1A/PLCB2/CSNK2A2/SLC39A9/RAF1/FRAT1/CSNK1A1/PPP3R1/PSEN1/NDUFA13/ULK2/PIK3CD/FZD1/RTN3/ATG13/EIF2AK2/WNT2B/MAP2K7/APC/PPP3CB/RELA/ULK1/BECN1/DVL1/KLC4/SLC39A14/SLC11A2/TUBA4A/IL1A/DDIT3/ERN1/FADD/IKBKG/ITPR3/CSF1/ATG2B/CASP7/PPP3CC/WNT6/EIF2AK3/IKBKB/ATG14/FZD8/SLC39A7/PIK3C3/MT-ND2/KLC1/ARAF/WIPI1/KRAS/CHUK/AKT2/PPP3CA/BACE1/PSMA6/ITPR1/PSEN2/PIK3R2/CDK5/FZD6/WNT5B/FZD7/MME/ATG2A/FZD5/MAPT/PSMA8/PIK3R3	0.774158082835816
NA	NA	hsa04519	Cadherin signaling	107/2333	404/9376	1.06440099646484	NFKBIA/VIM/TJP1/MAPK3/AMOTL2/VAV3/MAP2K3/EVL/YWHAG/ANKRD6/KRT14/LHFPL2/TCF7L2/NCKAP1L/CTNND2/KRT7/TEAD1/RAC2/EGFR/MAPK8/TMC4/PTK2/ADAM10/CREBBP/SHOC2/EP300/TAOK1/MRAS/GJA1/WWTR1/MAP2K1/NCSTN/MAPK1/KRT15/TCF7/NFKB1/PCDH1/FAT1/VAV1/DAAM1/MYO1F/ARPC2/LATS1/RAF1/PKP2/MYO1D/MET/CSNK1A1/CELSR1/RYK/PSEN1/FMN1/CDH23/MYO1C/FZD1/TMC1/WNT2B/MYO1G/APC/AMOTL1/RELA/TCF7L1/DVL1/STK3/PTK2B/FAT2/CYFIP2/MAPK14/ATN1/IKBKG/KRT8/ARHGAP35/BRK1/CYFIP1/TAOK3/RERE/WNT6/IKBKB/NF2/CDH18/FZD8/JUP/FGFR1/KRAS/CHUK/VAV2/KRT16/YAP1/SCN1B/PSEN2/LIMD1/TAOK2/FZD6/WTIP/WNT5B/FZD7/CELSR2/GABRE/KRT9/WASF1/FZD5/TMC8/AJUBA/ACTR3C/KRT17/LHFPL5/KRT86	0.761557677379205
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	31/2333	110/9376	1.13258777227916	ANAPC13/PIK3R1/MAPK3/ADCY7/CPEB2/MAPK8/ANAPC16/GNAI2/MAP2K1/AKT3/PIK3CA/CPEB4/MAPK1/RPS6KA3/MAD2L2/RAF1/PIK3CD/MAPK14/PRKACA/PRKACB/RPS6KA2/ARAF/KRAS/AKT2/PDE3B/PIK3R2/FZR1/ADCY9/HSP90AA1/CPEB3/PIK3R3	0.805040689718736
Organismal Systems	Digestive system	hsa04978	Mineral absorption	18/2333	61/9376	1.18589306669103	HMOX1/FTL/FTH1/MT1X/ATP1B1/VDR/TRPM7/SLC11A2/ATP7A/SLC31A1/MT1F/CYBRD1/MT1M/ATOX1/MT2A/ATP1A4/SLC8A1/MT1H	0.838302658344003
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	22/2333	76/9376	1.16335416337672	GNAQ/ITPR2/CAMK2G/ADCY7/SLC4A2/KCNJ2/ATP1B1/GNAI2/KCNJ15/PLCB2/CAMK2D/PRKCB/SLC9A1/ITPR3/PRKACA/PRKACB/KCNQ1/ITPR1/ATP1A4/ADCY9/PRKCA/CA2	0.822923932914312
Organismal Systems	Endocrine system	hsa04924	Renin secretion	20/2333	69/9376	1.16488690931003	GNAQ/CTSB/ITPR2/PTGER4/KCNJ2/GNAI2/PLCB2/PPP3R1/KCNMA1/PPP3CB/PTGER2/ITPR3/PRKACA/PPP3CC/PRKACB/PPP3CA/ITPR1/PDE3B/EDN1/AGTR1	0.791170397601219
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/2333	14/9376	1.43530708468557	FUT8/ST3GAL2/B4GALT2/B3GNT7/ST3GAL3	0.938079398272444
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	13/2333	43/9376	1.2150041368036	ACOX1/CPT1A/ACSL5/ACSL3/ACSL1/ACAA2/ACADVL/CPT2/ACADM/ACOX3/CPT1B/ALDH3A2/CYP2U1	0.813269666783831
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	43/2333	157/9376	1.10070683437033	PRKAG2/PIK3R1/RXRA/JUN/MLXIP/IL1B/IRS2/FOS/CEBPA/MAPK8/BID/IL6R/AKT3/MAP3K5/PIK3CA/TNF/BCL2L11/NFKB1/ATF4/TNFRSF1A/PPARA/NDUFA13/SREBF1/PIK3CD/RELA/ITCH/IL1A/MAP3K11/DDIT3/MAPK14/ERN1/NR1H3/CASP7/EIF2AK3/IKBKB/BAX/PRKAA1/PRKAB2/AKT2/PIK3R2/PRKAB1/LEPR/PIK3R3	0.732370810469392
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	15/2333	51/9376	1.18201759915282	PLA2G7/PLD3/GDPD3/PAFAH1B2/LPCAT2/LPCAT1/PLD1/TMEM86A/PLD4/CEPT1/PAFAH2/GDPD1/PLA2G4C/PLB1/PLA2G6	0.750132898780908
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/2333	18/9376	1.33961994570653	LMBRD1/PRDX1/TCN2/ABCD4/ZNF76/CD320	0.830045852254683
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	125/2333	480/9376	1.04657808258323	SQSTM1/HIP1/GNAQ/MAPK3/TUBB2A/ITPR2/PINK1/RAB5A/MAP1LC3B/MAP2K3/CAMK2G/ATXN1/IL1B/CYBB/DNAH11/PRNP/MAPK8/CAPN2/TUBA1A/PPIF/RB1CC1/BID/OPTN/UBE2L6/MAP2K1/PTGS2/MAP3K5/TNF/ATXN2/CHRM5/MAPK1/NFKB1/RAB1A/UBE2G2/ATF4/UBC/MT-ND4L/TNFRSF1A/ATXN2L/PLCB2/CSNK2A2/RAF1/CAMK2D/FRAT1/CSNK1A1/DCTN4/PPP3R1/PSEN1/TNFRSF1B/NDUFA13/ULK2/PRKCB/FZD1/C9orf72/UBB/SPG11/ATG13/WNT2B/LRRK2/MAP2K7/GPX3/APC/PPP3CB/RELA/SOD1/ULK1/DCTN1/BECN1/DVL1/KLC4/UBA7/DCTN6/CAT/ATXN1L/TUBA4A/IL1A/BCL2L1/MAP3K10/DDIT3/MAPK14/ERN1/FADD/ITPR3/MFN2/UBE2J1/CSF1/ATG2B/BCL2/CASP7/PPP3CC/TBK1/WNT6/DNAL4/EIF2AK3/GPR37/ATG14/FZD8/BAX/PIK3C3/MT-ND2/KLC1/ARAF/WIPI1/KRAS/PPP3CA/ZFYVE1/FIG4/PSMA6/ITPR1/PSEN2/CDK5/FZD6/WNT5B/FZD7/MAP1LC3B2/ATG2A/STX1A/FUS/DNAH14/FZD5/PRKCA/PLCG1/GPX1/MAPT/PSMA8	0.602932926429896
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	24/2333	86/9376	1.1215422801264	CREB5/GNAQ/VAMP2/CAMK2G/ADCY7/ATP1B1/CREB3L2/ATF4/GNA11/PLCB2/CAMK2D/ATF6B/KCNMA1/PRKCB/ATF2/ITPR3/PRKACA/KCNMB1/PRKACB/ATP1A4/STX1A/ADCY9/PRKCA/KCNMB4	0.651677777258492
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	20/2333	71/9376	1.13207319355481	PIK3R1/MAPK3/EGFR/SLC1A5/MAP2K1/AKT3/PIK3CA/HK3/MAPK1/RAF1/MET/PIK3CD/HIF1A/SIRT6/FGFR1/KRAS/AKT2/PIK3R2/FGFR2/PIK3R3	0.64290947797776
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	11/2333	37/9376	1.19479616779231	GNAQ/IL1B/APOL1/ICAM1/IL18/TNF/IL10/PLCB2/PRKCB/HBB/PRKCA	0.683274552693217
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/2333	30/9376	1.20565795113588	PIGT/B3GALT4/PGAP3/MPPE1/PIGP/PIGV/PIGQ/PIGM/PIGA	0.649317947620812
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/2333	12/9376	1.33961994570653	CD46/NPC1/ASGR1/FCGR2B	0.677512437350795
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	59/2333	226/9376	1.04917137340733	NFKBIA/CREB5/PIK3R1/ACOX1/MAPK3/JUN/VAV3/CAMK2G/POMC/ADCY7/PDE10A/PTGER3/FOS/RAC2/TIAM1/MAPK8/CREBBP/EP300/ATP1B1/GNAI2/MAP2K1/AKT3/PIK3CA/MAPK1/NFKB1/CREB3L2/VAV1/PLD1/GLI3/SUCNR1/RAF1/CAMK2D/PDE4C/RAP1A/CRH/PPARA/PIK3CD/PDE4B/RAP1B/RELA/SLC9A1/PTGER2/PRKACA/PDE4A/PRKACB/VAV2/AKT2/ACOX3/PDE3B/RAPGEF3/PIK3R2/EDN1/PTCH1/ATP1A4/HCAR1/FXYD1/NFATC1/ADCY9/PIK3R3	0.430645759053711
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/2333	54/9376	1.11634995475544	SDS/IL4I1/SDSL/BCAT1/TST/LACC1/AMD1/MAT2A/DNMT1/ENOPH1/GCLC/MAT2B/DNMT3A/MRI1/AHCYL2	0.493483586898113
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	15/2333	54/9376	1.11634995475544	ERCC1/REV1/WDR48/POLI/ERCC4/RMI1/HES1/TOP3B/MUS81/ATR/POLH/RPA4/FANCE/EME2/FAN1	0.493483586898113
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	26/2333	97/9376	1.0772201625269	GNAQ/MAPK3/CAMK2G/ADCY7/FOS/GNAI2/MAPK1/GNG12/PLCB2/CAMK2D/RPS6KA5/PRKCB/GNGT2/PER2/GNG10/ITPR3/PRKACA/PRKG1/PRKACB/PER1/ITPR1/PER3/GNG7/ADCY9/RASD1/PRKCA	0.439977182754598
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/2333	24/9376	1.17216745249321	EXTL3/NDST1/EXT2/XYLT1/GLCE/EXT1/NDST2	0.486036168480263
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	16/2333	59/9376	1.08986029481209	GSTT1/RRM2B/GPX4/GSTO1/GPX3/PGD/GSTK1/GCLC/GSR/GGT5/GGT7/GSTA3/HPGDS/ANPEP/GSTM4/GPX1	0.398492324360071
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	17/2333	63/9376	1.08445424176243	PTGES/HPGD/TBXAS1/ALOX5/PTGS2/PTGS1/GPX4/LTA4H/LTC4S/PLA2G4C/GGT5/EPHX2/CBR3/PLB1/PLA2G6/HPGDS/CYP2U1	0.387089243992876
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	35/2333	134/9376	1.04970219626258	GNAQ/MAPK3/ITPR2/ADCY7/GNA13/ADM/MAP2K1/MAPK1/PPP1R12B/GNA11/PLCB2/RAF1/KCNMA1/PRKCB/ADORA2B/ARHGEF12/ITPR3/PRKACA/KCNMB1/PRKG1/PRKACB/PRKCE/ARHGEF1/ARAF/PLA2G4C/ARHGEF11/ITPR1/EDN1/PLA2G6/ADCY9/NPPB/AGTR1/PRKCA/KCNMB4/ACTG2	0.333510230430207
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/2333	36/9376	1.11634995475544	GALNT7/GALNT6/B4GALT5/B3GNT3/GALNT3/ST6GALNAC2/ST3GAL2/GALNT11/GALNT12/GALNT10	0.402539214143381
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	13/2333	48/9376	1.08844120588656	PIK3R1/ATP1B1/AKT3/PIK3CA/HK3/PLCB2/PIK3CD/PRKCB/AKT2/PIK3R2/SLC2A5/ATP1A4/PIK3R3	0.353545382010642
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	65/2333	254/9376	1.02844838351486	P2RX4/GNAQ/ITPR2/PLCD3/CXCR4/CAMK2G/ADCY7/PDGFB/PTGER3/FLT1/EGFR/PTAFR/PPIF/ORAI3/STIM2/P2RX7/MCOLN1/GNA15/EDNRB/PHKB/CHRM5/ORAI2/VEGFA/ERBB3/CAMK1/GNA11/PLCB2/CAMK2D/MET/CAMK1D/NFATC3/PPP3R1/TPCN1/PHKA2/PRKCB/ADORA2B/GNAL/SPHK1/PPP3CB/PTK2B/CD38/CACNA1A/PLCG2/ITPR3/PRKACA/PPP3CC/PRKACB/ITPKC/FGFR1/PDGFC/PPP3CA/ITPR1/HRH1/TFEB/NFATC1/CASQ1/ADCY9/SLC8A1/FGF1/AGTR1/PRKCA/PLCG1/SPHK2/FGFR2/PHKA1	0.264541359959314
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	5/2333	17/9376	1.18201759915282	ADO/GGT5/FMO4/GGT7/FMO5	0.432302037165317
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	58/2333	227/9376	1.02684524472659	NFKBIA/FOXO3/PIK3R1/HMOX1/MAPK3/JUN/GSTT1/NCF2/AHR/FOS/EGFR/MAPK8/PDPK1/PTK2/PPIF/NFE2L2/SOS1/MAP2K1/AKT3/MAP3K5/PIK3CA/ABL2/MAPK1/NFKB1/VEGFA/PLD1/MT-ND4L/RAF1/MET/NDUFA13/PIK3CD/GSTO1/SOD2/MAP2K7/RELA/SOD1/HIF1A/CAT/MAPK14/IKBKG/MAP2K4/IKBKB/AKR1A1/MT-ND2/ARAF/KRAS/PRKD2/CHUK/AKT2/EPHX2/GSTA3/PIK3R2/CYP1B1/PTPRJ/EPHX3/GSTM4/NCF1/PIK3R3	0.235644683372634
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	23/2333	88/9376	1.05038382106535	SERPINE1/SERPING1/CD46/ITGB2/C1QB/C1QA/SERPINE2/C5AR1/SERPINA1/C1QC/A2M/ITGAX/C2/CD59/C3AR1/ITGAM/VSIG4/CLU/C3/PLAUR/PLAU/C4BPB/VWF	0.273297398089178
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	59/2333	233/9376	1.0176512033908	FBN1/BGN/FMNL2/VIM/SYNE1/HSPG2/FBLN1/MYOZ1/FN1/FMNL1/DIAPH2/FBN2/COL11A1/SDC2/ITGB1/ITGA6/ATP1B1/SUN2/COL4A2/SUN1/TLN2/ITGB6/COL4A1/DAG1/ITGA3/FHL1/DAAM1/AMPD3/SNTB1/FHL2/PKP2/AMPD2/SYNE3/THBS3/AGRN/TMEM43/FMNL3/ITGA2/TNNT3/NEBL/ITGA1/ITGB4/SYNE2/ITGA4/PDLIM3/ITGB7/ZYX/TMOD3/JUP/ANKRD1/ITGA5/INF2/PDLIM5/TNNI2/ENO3/TPM1/ATP1A4/CSRP2/ACTG2	0.15702618636829
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/2333	10/9376	1.20565795113588	TST/PAPSS2/ETHE1	0.37448341754145
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	39/2333	154/9376	1.01776320550431	CREB5/GNAQ/MAPK3/CAMK2G/ADCY7/PPP2CB/ATP1B1/GNAI2/AKT3/PPP2R5E/MAPK1/PIK3R5/CREB3L2/ATF4/PLCB2/CAMK2D/RPS6KA5/ATF6B/CACNA2D4/PPP2R2D/ATF2/PPP2R3C/SLC9A1/MAPK14/PRKACA/BCL2/PRKACB/KCNQ1/CACNA2D3/AKT2/SCN1B/RAPGEF3/TPM1/ATP1A4/PPP2R5B/ADCY9/SLC8A1/AGTR1/PRKCA	0.127918484379608
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	10/2333	38/9376	1.05759469397884	PTPRC/CD4/BTK/CD40/IL2RG/BLNK/IL7R/CIITA/IKBKG/JAK3	0.204744150060273
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	29/2333	115/9376	1.01345161109972	DUSP1/GNAQ/MAPK3/ITPR2/MAOA/ALOX5/GNAI2/MAP2K1/PTGS2/MAPK1/GNG12/PTGS1/PLCB2/RAF1/SLC6A4/PRKCB/GNGT2/GNG10/CACNA1A/ITPR3/PRKACA/PRKACB/ARAF/KRAS/PLA2G4C/ITPR1/RAPGEF3/GNG7/PRKCA	0.08353307029565
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/2333	23/9376	1.04839821837902	B4GALT2/POMT2/FKRP/ST3GAL3/B3GAT2/POMT1	0.133746365489808
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/2333	23/9376	1.04839821837902	CTSA/PRCP/ATP6AP2/MME/ANPEP/AGTR1	0.133746365489808
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/2333	44/9376	1.0047149592799	GTF2I/TAF7/TAF5L/TAF1/TAF13/GTF2E2/TBP/TAF11/GTF2H1/TAF4B/TAF4	0.0180418506303667
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	22/2333	89/9376	0.993426027153157	GLUL/GABARAPL2/GABARAP/GABARAPL1/ADCY7/GNAI2/GNG12/SLC38A1/PRKCB/SLC38A2/GNGT2/ABAT/GNG10/CACNA1A/PRKACA/PRKACB/TRAK2/GNG7/GABRE/ADCY9/PRKCA/GPHN	-0.0358632257415329
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/2333	28/9376	1.0047149592799	ACAA2/PPT1/ACOT2/ELOVL5/ELOVL4/ACOT7/MECR	0.0143800956097989
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/2333	28/9376	1.0047149592799	B3GNT3/ST3GAL6/ST8SIA1/B4GALT2/A4GALT/ST3GAL3/GCNT2	0.0143800956097989
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/2333	65/9376	0.989257806060206	MGLL/LPIN2/LPL/GK/GPAM/DGKH/AGPAT1/PNPLA3/LPIN1/PNPLA2/DGKA/AKR1A1/AGPAT3/AGPAT4/MBOAT1/ALDH3A2	-0.0500167728776575
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	21/2333	86/9376	0.981349495110597	TCF7L2/ITGB1/ITGA6/GJA1/ITGB6/DAG1/ITGA3/TCF7/SNTB1/PKP2/CACNA2D4/ITGA2/TCF7L1/ITGA1/ITGB4/ITGA4/ITGB7/JUP/ITGA5/CACNA2D3/SLC8A1	-0.0999991077873071
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/2333	37/9376	0.977560500920981	GMDS/UGDH/GNE/HK3/GFPT1/UXS1/PMM2/NANP/GFPT2	-0.0787096526058135
Human Diseases	Substance dependence	hsa05032	Morphine addiction	22/2333	91/9376	0.971592488094846	ADCY7/PDE10A/GRK4/ARRB2/GNAI2/GNG12/PDE4C/PRKCB/GNGT2/PDE4B/PDE7A/GNG10/CACNA1A/ARRB1/PRKACA/PDE4A/PRKACB/PDE3B/GNG7/GABRE/ADCY9/PRKCA	-0.156720967072094
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	31/2333	128/9376	0.9733176168024	ADCY7/PDE10A/ENTPD1/NT5E/GDA/ENTPD4/NME3/RRM2B/LACC1/AMPD3/PDE4C/AMPD2/PAPSS2/NT5C2/NME4/PDE4B/CANT1/PDE7A/ENTPD8/AK9/NME6/PDE4A/HPRT1/PDE6H/PDE6G/PDE3B/AK3/ENPP4/ENTPD5/ADCY9/GMPR	-0.174932238937169
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	15/2333	63/9376	0.956871389790378	POLD4/DDB1/XPC/ERCC1/RFC1/UVSSA/DDB2/POLR2A/POLR2M/POLR2J3/ERCC4/GTF2H1/ERCC5/RPA4/ERCC6	-0.19767652603487
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	33/2333	138/9376	0.961031700180771	ANAPC13/MAPK3/ITPR2/CAMK2G/YWHAG/ADCY7/CPEB2/PPP2CB/ANAPC16/MAP2K1/CPEB4/PPP2R5E/MAPK1/RPS6KA3/MAD2L2/CAMK2D/FBXW11/PPP3R1/PPP3CB/MAPK14/ITPR3/PRKACA/PPP3CC/PRKACB/RPS6KA2/SKP1/PPP3CA/ITPR1/BTRC/PPP2R5B/ADCY9/CPEB3/STAG3	-0.265415441342286
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/2333	17/9376	0.945614079322256	PAPSS2/SEPHS2/TXNRD3/TXNRD2	-0.129169621023077
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/2333	93/9376	0.950698025985279	LYZ/GNAQ/VAMP2/ITPR2/ADCY7/SLC4A2/ATP1B1/PLCB2/KCNMA1/PRKCB/SLC9A1/CD38/SLC12A2/ITPR3/PRKACA/PRKG1/PRKACB/CST3/ITPR1/ATP1A4/ADCY9/PRKCA	-0.274995616364711
NA	NA	hsa04382	Cornified envelope formation	52/2333	217/9376	0.963044753595477	COL17A1/TJP1/CLDN19/UGCG/DST/SLC27A1/LAMA5/KRT14/KRT7/S100A8/S100A4/PPP2CB/S100A9/ST14/ITGA6/COL4A2/PCSK6/COL4A1/PPP2R5E/KRT15/LAMA3/CLDN23/PKP2/SPTLC2/SPRR2G/S100A2/LAMB3/ELOVL4/PPP2R2D/PPP2R3C/LAMC2/ITGB4/CLDN9/PADI2/KRT8/S100A13/JUP/CLDN14/KAZN/EPHX2/S100A10/KRT16/PRSS8/TMEM79/CLDN15/PPL/PPP2R5B/EPHX3/KRT9/S100A12/KRT17/KRT86	-0.316990395094471
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/2333	52/9376	0.927429193181443	SCARB1/ADCY7/ALOX5/PTGS2/LDLR/ACOT2/PRKACA/PRKACB/PLA2G4C/CYP1B1/HSD17B1/ADCY9	-0.302013707161193
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	56/2333	235/9376	0.957685748419987	PRKAG2/CREB5/MGLL/MAP2K3/ADCY7/RHEB/CPT1A/ACSL5/ACSL3/SOS1/ACSL1/COX14/MAP3K5/RPS6KA3/CREB3L2/MT-ND4L/SLC25A20/NDUFA13/SMARCE1/SMARCD2/FRS2/ATF2/TSC1/SMARCC2/KDM3A/ARID1A/PNPLA2/TSC2/MAPK14/ARID1B/SIRT6/PRKACA/RPS6KB1/PRKG1/COX19/KDM3B/SMARCD1/PRKACB/RPS6KA2/CPT2/DPF1/FGFR1/PRKAA1/MT-ND2/PRKAB2/KRAS/RPTOR/PRKAB1/CPT1B/KLB/SLC25A29/ADCY9/NPPB/COX18/PRDM16/SMARCD3	-0.37808365603524
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/2333	22/9376	0.913377235708997	AOC1/MAOA/HNMT/ALDH3B1/ALDH3A2	-0.234104013731165
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/2333	31/9376	0.907484479349584	ACOX1/DPYD/MLYCD/ALDH3B1/ABAT/ACOX3/ALDH3A2	-0.296940855016676
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/2333	31/9376	0.907484479349584	GLUL/HYI/AGXT/MCEE/CAT/CS/AMT	-0.296940855016676
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/2333	44/9376	0.913377235708997	MAN1A1/HEXB/HEXA/MGAT4A/FUT8/MGAT2/MGAT4B/B4GALT2/MAN1C1/ST3GAL3	-0.331463090506652
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	23/2333	99/9376	0.933674507613642	PRKAG2/TGFB2/ITGB1/ITGA6/TNF/ITGB6/DAG1/ITGA3/SNTB1/CACNA2D4/ITGA2/ITGA1/ITGB4/ITGA4/ITGB7/PRKAA1/ITGA5/PRKAB2/CACNA2D3/EDN1/TPM1/PRKAB1/SLC8A1	-0.38181981702055
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/2333	78/9376	0.927429193181443	PABPC1/CNOT6L/CNOT1/XRN1/CNOT4/LSM1/CNOT6/DDX6/CNOT2/PATL1/ZCCHC7/TOB1/DCP1B/BTG2/DIS3L/PAN3/ENO3/PABPC1L	-0.370406539295804
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	77/2333	323/9376	0.958056369839654	TIMP3/CDKN1A/MARCKS/VIM/BMPR2/PIM1/PIK3R1/HMOX1/TGFB2/MAPK3/DICER1/FOXP1/NOTCH2/CD44/CDKN2A/IRS2/PDGFB/ZEB2/MMP9/SOX4/SOCS1/RECK/EGFR/SOS1/BMI1/CREBBP/ST14/EP300/MAP2K1/PTGS2/MDM2/PIK3CA/MIR29A/BCL2L11/MAPK1/NFKB1/VEGFA/ERBB3/MCL1/RAF1/ATM/MET/PDCD4/RPS6KA5/RASSF1/STAT3/PIK3CD/PRKCB/APC/DNMT1/CRK/FSCN1/PLAU/SIRT1/PLCG2/HDAC5/MDM4/BCL2/IKBKB/PRKCE/ITGA5/KRAS/BMF/DNMT3A/PIK3R2/NOTCH1/RPTOR/TPM1/CDK6/CYP1B1/EFNA5/HDAC4/BCL2L2/PRKCA/PLCG1/TP63/PIK3R3	-0.44150454599685
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/2333	27/9376	0.893079963804353	ACOX1/ACOT2/ELOVL5/ELOVL4/ACOT7/ACOX3	-0.320200910634742
Cellular Processes	Cell motility	hsa04814	Motor proteins	45/2333	194/9376	0.932209756032894	TUBB2A/DYNLT1/KIF21A/MYO7B/DNAH11/DYNC1LI2/TUBA1A/MYO9B/KIF12/MYO1F/MYO5A/MYO1D/DCTN4/MYO1C/HOOK3/MYO9A/MYO6/MYO1G/TNNT3/DCTN1/DYNLRB1/KIF3B/KLC4/KIF13A/DCTN6/TUBA4A/KIF3C/DNAL4/MYO5B/KIF1B/KIF16B/KIFC3/KLC1/TNNI2/TPM1/KIF26B/KIF27/KIFC2/DNAH14/KIF13B/TUBG2/MYL10/DYNLRB2/KIF26A/ACTG2	-0.549115346022873
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/2333	37/9376	0.868942667485316	GLUL/IL4I1/AGXT/GFPT1/ABAT/GPT/RIMKLB/GFPT2	-0.459701755255329
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	23/2333	102/9376	0.906213492683829	GNAQ/ITPR2/ADCY7/SLC4A2/ATP1B1/RAB27B/PLCB2/RAP1A/KCNMA1/PRKCB/CTRB2/RAP1B/SLC9A1/CD38/SLC12A2/ITPR3/KCNQ1/ITPR1/ATP1A4/RAB3D/ADCY9/PRKCA/CA2	-0.548114216031397
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/2333	42/9376	0.86118425081134	AOC1/MAOA/IL4I1/CAT/KYNU/HAAO/CYP1B1/KMO/ALDH3A2	-0.518911925488194
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	23/2333	103/9376	0.897415303434471	COL17A1/PRCP/SLC7A7/COL11A1/ATP1B1/SLC1A5/SLC16A10/COL4A2/COL4A1/COL12A1/DPP4/SLC38A2/CTRB2/COL8A2/COL23A1/KCNQ1/KCNE3/SLC7A8/SLC7A9/ATP1A4/MME/SLC8A1/COL16A1	-0.602497465129724
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/2333	47/9376	0.855076561089274	ME2/HAGH/ACYP2/ME1/ME3/AKR1A1/PCK2/ALDH3A2/ACACB/LDHD	-0.573236950202367
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	18/2333	82/9376	0.882188744733568	UPP1/GSTT1/TK2/DPYD/NME3/GUSB/CMPK1/RRM2B/CES2/CDA/GSTO1/NME4/NME6/UCK2/HPRT1/GSTA3/CES1/GSTM4	-0.616675278890876
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/2333	16/9376	0.753536219459923	MAOA/IL4I1/ALDH3B1	-0.567857460951681
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/2333	35/9376	0.803771967423918	GMDS/FBP1/PFKFB3/HK3/PMM2/HSD17B14/PFKFB2	-0.669364304907252
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/2333	21/9376	0.765497111832303	DPYD/BCAT1/PANK3/ALDH3A2	-0.619156035500195
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/2333	26/9376	0.772857660984536	ACOX1/PLA2G4C/ACOX3/PLB1/PLA2G6	-0.667487482319429
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2333	26/9376	0.772857660984536	SCARB1/LMBRD1/TCN2/ABCD4/PLB1	-0.667487482319429
NA	NA	hsa04081	Hormone signaling	49/2333	219/9376	0.899196949857807	CSH2/CSH1/PIK3R1/GNAQ/POMC/ADCY7/IRS2/HAMP/IGF2/GNA13/GUCA2A/SMAD4/GNAI2/SLC16A10/THRB/GNA15/PIK3CA/BMPR1B/GNG12/GNA11/PLCB2/JAK2/CRH/CSHL1/STAT3/PIK3CD/GNGT2/STK11/PRLR/GNG10/SMAD1/PRKACA/PRKG1/EPOR/PRKACB/STAT5A/ACVR1/RAPGEF3/PIK3R2/LEPR/MC1R/GNG7/ADCY9/NPPB/AGTR1/OPRK1/ESR2/VIPR1/PIK3R3	-0.868726935045213
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/2333	17/9376	0.709210559491692	CYP27A1/HSD3B7/CYP39A1	-0.69064127921147
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/2333	32/9376	0.753536219459923	GALM/GAA/GLB1/HK3/B4GALT2/GANC	-0.803758990098035
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/2333	32/9376	0.753536219459923	ACOX1/MCEE/MLYCD/ABAT/ACOX3/ACACB	-0.803758990098035
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	22/2333	105/9376	0.842046823015533	TGFB2/ADCY7/ITGB1/ITGA6/TNF/ITGB6/DAG1/ITGA3/SNTB1/CACNA2D4/ITGA2/ITGA1/ITGB4/ITGA4/PRKACA/ITGB7/PRKACB/ITGA5/CACNA2D3/TPM1/ADCY9/SLC8A1	-0.936750401459639
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	45/2333	205/9376	0.882188744733568	CTSD/PIK3R1/TGFBR1/TGFB2/MPC1/CAMK2G/CD36/NCF2/CYBB/MMP9/RAC2/MAPK8/SMAD3/PPIF/PDK4/AKT3/PIK3CA/MPC2/NFKB1/TGFBR2/MT-ND4L/SMAD2/SP1/PLCB2/CAMK2D/GFPT1/PPARA/NDUFA13/PIK3CD/PRKCB/TBC1D4/RELA/MAPK14/CPT2/GSR/NCF4/MT-ND2/AKT2/PIK3R2/CPT1B/AGTR1/PRKCA/GFPT2/NCF1/PIK3R3	-0.981566054070344
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	32/2333	149/9376	0.863110837502194	MGLL/GNAQ/MAPK3/ITPR2/ADCY7/SLC17A8/DAGLB/MAPK8/GNAI2/PTGS2/MAPK1/GNG12/MT-ND4L/PLCB2/NDUFA13/PRKCB/GNGT2/FAAH/GNG10/CACNA1A/MAPK14/ITPR3/PRKACA/ABHD6/PRKACB/MT-ND2/NAPEPLD/ITPR1/GNG7/GABRE/ADCY9/PRKCA	-0.969384572462199
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/2333	23/9376	0.698932145586015	PCYOX1/IDI1/FNTA/PDSS2	-0.831987883899826
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/2333	23/9376	0.698932145586015	ATP1B1/PCK2/ATP1A4/CA2	-0.831987883899826
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/2333	13/9376	0.618286128787629	RAD50/POLM	-0.792622269414228
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/2333	34/9376	0.709210559491692	CRCP/POLR3D/POLR2A/POLR2M/POLR2J3/POLR3A	-0.977602542298511
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	33/2333	158/9376	0.839382117879408	CDKN1A/GADD45B/ANAPC13/TGFB2/YWHAG/CDKN2A/PPP2CB/SMAD3/GADD45A/ANAPC16/RBL2/RB1/CREBBP/EP300/SMAD4/MDM2/PPP2R5E/MAD2L2/PDS5A/SMAD2/ATM/NIPBL/CDKN2B/MAU2/CDC14A/STAG1/CDKN1C/SKP1/GADD45G/ATR/CDK6/FZR1/PPP2R5B	-1.17183981591094
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/2333	45/9376	0.714463971043482	ABCA1/ABCG1/ABCD1/ABCC3/ABCD4/ABCC10/ABCA4/ABCA5	-1.10501262746235
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/2333	36/9376	0.669809972853265	GAA/HK3/PYGB/GYG1/PGM2L1/GANC	-1.14236773297424
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/2333	41/9376	0.686146801459442	PIPOX/MAOA/SDS/SDSL/BPGM/AGXT/AMT	-1.15911223383399
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/2333	41/9376	0.686146801459442	POLD4/ATM/RAD50/UIMC1/TOP3B/MUS81/RPA4	-1.15911223383399
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2333	31/9376	0.648203199535417	UGDH/GUSB/AKR1A1/HSD17B14/ALDH3A2	-1.12913857034663
NA	NA	hsa04981	Folate transport and metabolism	5/2333	31/9376	0.648203199535417	SLCO2B1/ABCC3/MTHFR/FOLR1/FOLR2	-1.12913857034663
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/2333	37/9376	0.651707000613987	MAOA/IL4I1/COMT/ALDH3B1/FAHD1/TH	-1.22168596055436
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	31/2333	154/9376	0.808991265913683	QPRT/NMNAT2/NME3/BCAT1/UGDH/GUSB/CMPK1/RFK/MAT2A/PANK3/NME4/CMPK2/GCLC/MTHFD2/PMM2/MAT2B/AK9/NME6/KYNU/PNPO/AKR1A1/HAAO/EARS2/NADSYN1/AK3/PTS/RDH13/KMO/ALDH3A2/NMNAT1/GPHN	-1.37551455798103
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/2333	33/9376	0.608918157139332	BCAT1/OGDH/AGXT/CS/GPT	-1.29522617352555
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	58/2333	275/9376	0.84761407473795	CREB5/PIK3R1/MAPK3/TUBB2A/ITPR2/C1QB/C1QA/HSPA1B/IL1B/NCF2/C1QC/CYBB/RAC2/PRNP/MAPK8/CCL5/EGR1/TUBA1A/PPIF/LAMC1/HSPA6/HSPA1A/PIK3CA/TNF/MAPK1/CREB3L2/ATF4/MT-ND4L/CSNK2A2/PPP3R1/ATF6B/NDUFA13/PIK3CD/PPP3CB/SOD1/ATF2/KLC4/TUBA4A/IL1A/DDIT3/MAPK14/ITPR3/PRKACA/PPP3CC/PRKACB/EIF2AK3/NCF4/BAX/MT-ND2/KLC1/PPP3CA/PSMA6/ITPR1/PIK3R2/NOTCH1/PSMA8/NCF1/PIK3R3	-1.47615108298216
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/2333	44/9376	0.639364064996298	POLD4/PARP4/MPG/RFC1/POLG/POLB/PARG	-1.37997791391771
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/2333	39/9376	0.618286128787629	MAT2A/MTHFR/MTHFD2/MAT2B/AHCYL2/AMT	-1.37477216279443
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/2333	17/9376	0.472807039661128	GLUL/CA2	-1.25211293739986
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/2333	23/9376	0.524199109189512	POLD4/RFC1/RPA4	-1.31485500859464
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	19/2333	103/9376	0.741343076750215	PABPC1/PPP2CB/MSI2/SYMPK/PPP2R5E/SMG1/WDR82/PPP2R2D/PPP2R3C/UPF2/NXF1/DDX19A/PCF11/UPF3A/PAPOLG/SMG5/PPP2R5B/FUS/PABPC1L	-1.51913634112766
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/2333	50/9376	0.643017573939134	AOC1/OAT/MAOA/SAT1/PYCR1/AMD1/L3HYPDH/ALDH3A2	-1.45662680190673
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/2333	56/9376	0.645888188108505	MAN1A1/MGAT5/MGAT4A/FUT8/MGAT2/DHRSX/MGAT4B/B4GALT2/MAN1C1	-1.52964493931627
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/2333	36/9376	0.558174977377721	UGDH/GUSB/CRYL1/AKR1A1/FGGY	-1.52859446975364
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/2333	19/9376	0.423037877591536	OGDH/AMT	-1.44883841261239
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/2333	31/9376	0.518562559628334	FBP1/H6PD/PGD/RBKS	-1.54523742801161
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/2333	48/9376	0.586083726246607	IL4I1/BCAT1/MCEE/ACAA2/ABAT/ACADM/ALDH3A2	-1.65463808026628
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/2333	26/9376	0.463714596590722	HHEX/HES1/MAFA	-1.57594482507265
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/2333	20/9376	0.401885983711959	LIPA/SOAT1	-1.54105462961556
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	11/2333	70/9376	0.63153511726165	GSTT1/PTGS2/GSTO1/SULT1A1/GSTK1/GSTA3/SULT1A3/CYP1B1/HSD11B1L/HPGDS/GSTM4	-1.78085172869249
Organismal Systems	Digestive system	hsa04976	Bile secretion	15/2333	90/9376	0.669809972853265	SCARB1/RXRA/ADCY7/SLC4A2/AQP9/ATP1B1/ABCC3/NCEH1/LDLR/SLC9A1/PRKACA/PRKACB/ATP1A4/ADCY9/CA2	-1.81148620215479
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	76/2333	368/9376	0.829981922883393	SQSTM1/TUBB2A/PINK1/RAB5A/MAP1LC3B/MAP2K3/DNAH11/CASP1/TUBA1A/RB1CC1/BID/NUP214/OPTN/MAP3K5/TNF/ATXN2/RAB1A/ATF4/MT-ND4L/TNFRSF1A/ATXN2L/SETX/DCTN4/PPP3R1/ANG/TNFRSF1B/NDUFA13/ULK2/C9orf72/SPG11/ATG13/UBQLN4/GPX3/PPP3CB/SOD1/ULK1/RANBP2/DCTN1/BECN1/KLC4/NXF1/DCTN6/CAT/ANXA11/TUBA4A/BCL2L1/DDIT3/MAPK14/UBQLN1/ERN1/POM121/ITPR3/ATG2B/BCL2/UBQLN2/PPP3CC/TBK1/DNAL4/EIF2AK3/ATG14/BAX/PIK3C3/NUP153/MT-ND2/KLC1/WIPI1/PPP3CA/FIG4/PSMA6/HDAC6/MAP1LC3B2/ATG2A/FUS/DNAH14/GPX1/PSMA8	-1.91500090716316
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	53/2333	268/9376	0.794774520027381	DUSP1/TUBB2A/ITPR2/PINK1/CAMK2G/MAOA/SLC39A11/SLC39A13/SLC39A8/MAPK8/TUBA1A/PPIF/NFE2L2/UBE2L6/GNAI2/MAP3K5/UBE2G2/ATF4/UBC/MT-ND4L/SLC39A9/CAMK2D/NDUFA13/GNAL/UBB/LRRK2/SOD1/KLC4/UBA7/SLC39A14/SLC11A2/TUBA4A/BCL2L1/DDIT3/ERN1/ITPR3/PRKACA/MFN2/UBE2J1/PRKACB/EIF2AK3/GPR37/SLC39A7/BAX/MT-ND2/KLC1/TH/PSMA6/ITPR1/TXN/PLCG1/MAPT/PSMA8	-1.96178463835243
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/2333	28/9376	0.43059212540567	TH/PTS/GPHN	-1.73662998799378
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/2333	46/9376	0.524199109189512	HMOX1/FTL/FTH1/BLVRA/GUSB/EARS2	-1.86177634561476
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/2333	46/9376	0.524199109189512	PSMB8/PSMB9/PSMB10/PSME4/PSMA6/PSMA8	-1.86177634561476
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	61/2333	308/9376	0.795943019689269	CREB5/HIP1/GNAQ/TUBB2A/SLC1A3/CLTB/DNAH11/MAPK8/TUBA1A/PPIF/RB1CC1/AP2B1/CREBBP/AP2A2/EP300/MAP3K5/CREB3L2/MT-ND4L/CLTC/SP1/PLCB2/DCTN4/BBC3/NDUFA13/ULK2/SOD2/ATG13/MAP2K7/GPX3/SOD1/ULK1/DCTN1/BECN1/KLC4/DCTN6/TUBA4A/MAP3K10/TBP/ERN1/ATG2B/DNAL4/POLR2A/ATG14/BAX/PIK3C3/MT-ND2/KLC1/POLR2J3/WIPI1/TAF4B/SIN3A/PSMA6/ITPR1/TAF4/AP2S1/ATG2A/STX1A/DNAH14/NRF1/GPX1/PSMA8	-2.09572947496229
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	25/2333	143/9376	0.702597873622306	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/FCGR3A/C1QB/C1QA/HLA-DMB/C1QC/HLA-DRB5/FCGR1A/HLA-DQA2/C2/CD86/FCGR2A/CD40/HLA-DOA/TNF/IL10/C3/ELANE/FCGR3B	-2.06255165386378
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/2333	23/9376	0.349466072793008	GLUL/GPT	-1.79772213328946
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/2333	30/9376	0.401885983711959	OGDH/CS/PCK2	-1.88840822032114
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/2333	30/9376	0.401885983711959	PLA2G4C/PLB1/PLA2G6	-1.88840822032114
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/2333	116/9376	0.65826152504545	ACOX1/FBP1/SDS/H6PD/SDSL/HK3/ME2/OGDH/AGXT/MCEE/PGD/CAT/ME1/ME3/CS/ACOX3/GPT/ENO3/AMT	-2.13148137291452
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/2333	43/9376	0.467309283385999	ABCA1/SCARB1/CD36/SLC27A1/AGPAT1	-2.01494356359874
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/2333	108/9376	0.63259830769475	EEF1A1/NUP214/XPOT/KPNA6/RANBP2/UPF2/NXF1/TNPO1/KPNA3/XPO7/DDX19A/POM121/IPO7/UPF3A/NUP153/TNPO2/KPNA5	-2.21016237304589
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/2333	67/9376	0.539846843792184	GALM/FBP1/BPGM/HK3/ALDH3B1/AKR1A1/PCK2/ENO3/ALDH3A2	-2.17546677466857
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	10/2333	73/9376	0.550528744810903	MAOA/GSTT1/ALDH3B1/GSTO1/GSTK1/FMO4/GSTA3/HPGDS/FMO5/GSTM4	-2.21878900814015
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/2333	79/9376	0.559588078586272	GSTT1/ALDH3B1/GSTO1/GSTK1/GSTA3/CYP1B1/CBR3/HSD11B1L/HPGDS/CYP2S1/GSTM4	-2.26237899451951
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/2333	75/9376	0.535847978282612	GLUL/SDS/PYCR1/SDSL/BCAT1/MAT2A/MAT2B/CS/GPT/ENO3	-2.32268448720434
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/2333	36/9376	0.334904986426632	POLD4/RFC1/RPA4	-2.30104794331245
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/2333	29/9376	0.277162747387558	PDE6G/SLC24A1	-2.24371436038191
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/2333	68/9376	0.472807039661128	RDH10/ALDH1A1/DHRS4L2/CYP26A1/DHRS4/RDH13/CYP2S1/CYP26B1	-2.51107702724291
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/2333	31/9376	0.259281279814167	SEC63/SEC62	-2.37743514334156
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/2333	66/9376	0.426242709997532	COMT/CYP1B1/HSD17B8/HSD11B1L/HSD17B1/SRD5A1/SULT2B1	-2.69208958142747
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2333	41/9376	0.294062914911189	SLC17A8/CACNA1A/GABRE	-2.6071434525712
Human Diseases	Substance dependence	hsa05034	Alcoholism	30/2333	191/9376	0.631234529390511	CREB5/MAPK3/MAOA/FOSB/SOS1/GNAI2/MAP2K1/MAPK1/SLC29A3/GNG12/CREB3L2/ATF4/RAF1/ATF6B/CRH/CAMKK2/ADORA2B/GNGT2/HDAC7/ATF2/GNG10/PRKACA/HDAC5/PRKACB/ARAF/KRAS/TH/HDAC6/HDAC4/GNG7	-2.96340845592752
NA	NA	hsa04082	Neuroactive ligand signaling	31/2333	199/9376	0.626053542465866	SLC6A2/P2RX4/GNAQ/SLC1A3/TAC3/POMC/ADCY7/SLC17A8/GNAI2/CHRM5/GNG12/GNA11/PLCB2/P2RY11/SLC6A4/PRKCB/ADORA2B/GNAL/GNGT2/GNG10/P2RY6/PRKACA/ADORA3/PRKACB/SLC1A6/HRH1/GNG7/GABRE/ADCY9/PRKCA/OPRK1	-3.06866697289955
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/2333	27/9376	0.148846660634059	ABAT	-2.54900843707226
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	19/2333	138/9376	0.553321281922262	ATP6V0D1/ATP6V0E1/ATP6V1G1/ATP6AP1/ATP6V1B2/ATP6V0A1/LHPP/MT-ND4L/ATP6V1H/ATP6V1C1/ATP6V0B/NDUFA13/ATP6V1A/ATP6V1E1/ATP6V1D/MT-ND2/ATP6V0A2/ATP6V1E2/ATP6V0E2	-3.04235570057661
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/2333	87/9376	0.369550329850077	ATP1B1/CACNA2D4/SLC9A1/CACNA2D3/TPM1/ATP1A4/SLC9A6/SLC8A1	-3.40008465428056
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/2333	86/9376	0.280385570031599	PLCB2/PKD2L1/CACNA1A/ITPR3/PRKACA/PRKACB	-3.8583835330163
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	48/2333	370/9376	0.52136560049119	CSH2/CSH1/P2RX4/PGRMC1/C5AR1/TAC3/POMC/PTGER3/FPR3/C3AR1/PTGER4/NR3C1/ADM/PTAFR/KISS1/FPR1/THRB/P2RX7/LPAR2/EDNRB/TSPO/CHRM5/P2RY11/GPR35/CRH/CSHL1/C3/ADORA2B/NPB/S1PR4/PRLR/PTGER2/LPAR6/P2RY6/UTS2/ADORA3/CHRNE/EDN1/HRH1/CHRNB1/LEPR/MC1R/GABRE/AGTR1/LTB4R/OPRK1/NPFFR2/VIPR1	-5.40633511632651
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/2333	183/9376	0.263531792598006	SBDS/REXO2/CSNK2A2/XRN1/UTP14C/NXF1/SNORD3D/SNORD3A/RPP25/DROSHA/SNORD3B-2/SNORD3B-1	-5.79048687731448
Genetic Information Processing	Translation	hsa03010	Ribosome	2/2333	222/9376	0.0362059444785549	RPS4Y1/RPS27L	-8.36410430202377
Genetic Information Processing	Transcription	hsa03040	Spliceosome	13/2333	243/9376	0.215000732026974	HSPA1B/HSPA6/HSPA1A/PRPF6/PCBP1/U2AF1L4/SLU7/SF1/DHX8/DDX5/SRSF5/PRPF40B/FUS	-7.13558893103876
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	13/2333	449/9376	0.1163589707852	RGS2/CAMK2G/ARRB2/NCALD/CAMK2D/GNAL/ANO2/ARRB1/PRKACA/PRKG1/PRKACB/GNG7/SLC8A1	-11.0435941835994