ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 246/4880 489/18639 0.503067484662577 1.92144976365282 7.39325289350682e-31 7.5563988685772e-28 GO:0060589 nucleoside-triphosphatase regulator activity 246/4880 490/18639 0.502040816326531 1.91752843760455 1.10797637369167e-30 7.5563988685772e-28 GO:0005096 GTPase activator activity 146/4880 271/18639 0.538745387453875 2.05772034359688 1.86402285641224e-22 8.4750905871543e-20 GO:0003712 transcription coregulator activity 224/4880 495/18639 0.452525252525253 1.72840536512668 1.53343570111001e-20 5.22901574078514e-18 GO:0019787 ubiquitin-like protein transferase activity 210/4880 479/18639 0.438413361169102 1.67450545877682 2.02336412842204e-17 5.51973734233532e-15 GO:0004842 ubiquitin-protein transferase activity 197/4880 449/18639 0.438752783964365 1.67580187301471 1.83774858079235e-16 3.73721167988465e-14 GO:0016755 aminoacyltransferase activity 213/4880 496/18639 0.429435483870968 1.64021475079323 1.91792388263875e-16 3.73721167988465e-14 GO:0005085 guanyl-nucleotide exchange factor activity 118/4880 230/18639 0.51304347826087 1.95955274411974 2.83757487741024e-16 4.83806516598446e-14 GO:0140297 DNA-binding transcription factor binding 207/4880 488/18639 0.424180327868852 1.62014285474335 2.44554820488893e-15 3.70636416829833e-13 GO:0031267 small GTPase binding 135/4880 283/18639 0.477031802120141 1.82200732781093 4.34691672933711e-15 5.92919441881581e-13 GO:0004674 protein serine/threonine kinase activity 186/4880 433/18639 0.429561200923788 1.64069492295461 1.54860489545796e-14 1.92027007036787e-12 GO:0051020 GTPase binding 145/4880 315/18639 0.46031746031746 1.75816744730679 1.71039029628807e-14 1.94414363678077e-12 GO:0106310 protein serine kinase activity 158/4880 361/18639 0.437673130193906 1.67167817083693 2.33274177563514e-13 2.44758444766641e-11 GO:0061659 ubiquitin-like protein ligase activity 160/4880 372/18639 0.43010752688172 1.6427815970386 9.51424033550771e-13 9.26958844116608e-11 GO:0003713 transcription coactivator activity 118/4880 256/18639 0.4609375 1.76053566854508 4.17981680635444e-12 3.80084674924497e-10 GO:0061630 ubiquitin protein ligase activity 151/4880 353/18639 0.427762039660057 1.63382308549668 6.89248832702768e-12 5.87584629879109e-10 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 148/4880 349/18639 0.424068767908309 1.61971675513176 2.42998637313493e-11 1.94970671350355e-09 GO:0001217 DNA-binding transcription repressor activity 118/4880 278/18639 0.424460431654676 1.62121270196957 2.33611603734588e-09 1.77025681941099e-07 GO:0016922 nuclear receptor binding 68/4880 137/18639 0.496350364963504 1.89579394519564 3.34067736609617e-09 2.39825469860799e-07 GO:0035403 histone H3T6 kinase activity 106/4880 247/18639 0.42914979757085 1.6391235813367 7.34522690881473e-09 5.00944475181164e-07 GO:0003714 transcription corepressor activity 91/4880 204/18639 0.446078431372549 1.70378194310511 8.72733575320023e-09 5.66861236541196e-07 GO:0004679 AMP-activated protein kinase activity 106/4880 248/18639 0.42741935483871 1.63251421205711 9.55476043339947e-09 5.92395146870767e-07 GO:0035091 phosphatidylinositol binding 118/4880 284/18639 0.415492957746479 1.58696172939275 1.03797998505932e-08 6.14721332798685e-07 GO:0140857 histone H3T45 kinase activity 105/4880 246/18639 0.426829268292683 1.63026039584166 1.22379154332655e-08 6.14721332798685e-07 GO:0035402 histone H3T11 kinase activity 105/4880 247/18639 0.425101214574899 1.62366015132409 1.58557484971204e-08 6.14721332798685e-07 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 112/4880 268/18639 0.417910447761194 1.59619525324199 1.66674036619334e-08 6.14721332798685e-07 GO:0035173 histone kinase activity 142/4880 360/18639 0.394444444444444 1.50656762295082 1.9918754746196e-08 6.14721332798685e-07 GO:0140996 histone H3 kinase activity 141/4880 357/18639 0.394957983193277 1.50852906736465 2.02793498920303e-08 6.14721332798685e-07 GO:0004676 3-phosphoinositide-dependent protein kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0004711 ribosomal protein S6 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0035175 histone H3S10 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0035979 histone H2AXS139 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0044022 histone H3S28 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0044023 histone H4S1 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0044024 histone H2AS1 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0044025 histone H2BS14 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0072354 histone H3T3 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0072371 histone H2AS121 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0072518 Rho-dependent protein serine/threonine kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0140823 histone H2BS36 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0140855 histone H3S57 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0140995 histone H2A kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0140997 histone H4 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0140998 histone H2B kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:1990244 histone H2AT120 kinase activity 104/4880 245/18639 0.424489795918367 1.62132485781198 2.02803958767895e-08 6.14721332798685e-07 GO:0019902 phosphatase binding 85/4880 190/18639 0.447368421052632 1.70870901639344 2.26407783842698e-08 6.71348298177044e-07 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 103/4880 243/18639 0.423868312757202 1.6189511232544 2.59302313495356e-08 7.43683013846824e-07 GO:0004677 DNA-dependent protein kinase activity 104/4880 246/18639 0.422764227642276 1.61473410635746 2.61706632438765e-08 7.43683013846824e-07 GO:0044389 ubiquitin-like protein ligase binding 129/4880 322/18639 0.400621118012422 1.53015922512982 3.01665065641591e-08 8.39737039867611e-07 GO:0140030 modification-dependent protein binding 78/4880 173/18639 0.450867052023121 1.72207192267602 5.62262786652291e-08 1.53385288198745e-06 GO:0141003 histone H2AX kinase activity 138/4880 354/18639 0.389830508474576 1.4889448457905 7.24661160230893e-08 1.9381133775587e-06 GO:0140767 enzyme-substrate adaptor activity 65/4880 139/18639 0.467625899280576 1.78608179030546 1.33895682645244e-07 3.45347270671849e-06 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 178/4880 484/18639 0.367768595041322 1.40468009077361 1.34189188750792e-07 3.45347270671849e-06 GO:0001216 DNA-binding transcription activator activity 179/4880 491/18639 0.364562118126273 1.39243305732697 2.45959729938701e-07 6.21276058585904e-06 GO:0031625 ubiquitin protein ligase binding 119/4880 302/18639 0.394039735099338 1.50502184887634 2.90099858813053e-07 7.19447649856371e-06 GO:0005543 phospholipid binding 179/4880 497/18639 0.360160965794769 1.37562300029686 6.21030232097063e-07 1.51265220817927e-05 GO:0043130 ubiquitin binding 49/4880 100/18639 0.49 1.87153893442623 8.17093434588614e-07 1.95529025399802e-05 GO:0001221 transcription coregulator binding 54/4880 115/18639 0.469565217391304 1.79348895224519 1.27105065751682e-06 2.98916051181541e-05 GO:0032182 ubiquitin-like protein binding 55/4880 120/18639 0.458333333333333 1.75058913934426 2.60835865235667e-06 6.03017152849916e-05 GO:0017124 SH3 domain binding 53/4880 115/18639 0.460869565217391 1.76027619387028 3.20992039253168e-06 7.29721902568868e-05 GO:0019955 cytokine binding 63/4880 144/18639 0.4375 1.6710169057377 3.56179179714454e-06 7.96440001853303e-05 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 55/4880 122/18639 0.450819672131148 1.72189095673206 4.85903880966636e-06 0.000105373489297515 GO:0001540 amyloid-beta binding 41/4880 83/18639 0.493975903614458 1.88672476792416 4.86695735025177e-06 0.000105373489297515 GO:0140375 immune receptor activity 66/4880 156/18639 0.423076923076923 1.61592843631778 8.36183003035187e-06 0.000175858467556523 GO:0046332 SMAD binding 39/4880 79/18639 0.493670886075949 1.8855597634364 8.38035219294281e-06 0.000175858467556523 GO:0042826 histone deacetylase binding 56/4880 127/18639 0.440944881889764 1.68417451916871 9.10208513854102e-06 0.000188109759529848 GO:0004721 phosphoprotein phosphatase activity 72/4880 175/18639 0.411428571428571 1.57143793911007 1.0847013188324e-05 0.00022082576102797 GO:1901981 phosphatidylinositol phosphate binding 75/4880 185/18639 0.405405405405405 1.54843265396544 1.34116786165416e-05 0.000269022494602394 GO:0042578 phosphoric ester hydrolase activity 131/4880 363/18639 0.360881542699725 1.37837522015987 1.70484127103401e-05 0.00033550912862222 GO:0019903 protein phosphatase binding 61/4880 144/18639 0.423611111111111 1.61796875 1.72182104131638e-05 0.00033550912862222 GO:0046966 nuclear thyroid hormone receptor binding 18/4880 28/18639 0.642857142857143 2.45537177985948 2.53404736286445e-05 0.00048242679700835 GO:0042393 histone binding 94/4880 247/18639 0.380566801619433 1.45356242118537 2.54653441236079e-05 0.00048242679700835 GO:0052742 phosphatidylinositol kinase activity 17/4880 26/18639 0.653846153846154 2.49734394703657 3.09144536704037e-05 0.00057763444940316 GO:0000149 SNARE binding 47/4880 106/18639 0.443396226415094 1.69353734921126 3.88991278365569e-05 0.000717005545527887 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 41/4880 89/18639 0.460674157303371 1.75952983974949 4.05716357705099e-05 0.000728154094618099 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 41/4880 89/18639 0.460674157303371 1.75952983974949 4.05716357705099e-05 0.000728154094618099 GO:0140789 histone phosphatase activity 57/4880 136/18639 0.419117647058824 1.60080611137898 4.60947139057779e-05 0.000816534932045209 GO:0004725 protein tyrosine phosphatase activity 44/4880 98/18639 0.448979591836735 1.71486283037805 4.69125313042883e-05 0.000820367855116015 GO:0140793 histone H2AXY142 phosphatase activity 41/4880 90/18639 0.455555555555556 1.73997950819672 5.58122886537125e-05 0.000963645085109669 GO:0030228 lipoprotein particle receptor activity 13/4880 18/18639 0.722222222222222 2.75850409836066 5.76148700334647e-05 0.000982333534070573 GO:0023026 MHC class II protein complex binding 17/4880 27/18639 0.62962962962963 2.40484972677596 6.30863207444612e-05 0.00106234248759809 GO:0061733 protein-lysine-acetyltransferase activity 25/4880 47/18639 0.531914893617021 2.03163149633763 7.25381126785821e-05 0.0012066095816291 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 16/4880 25/18639 0.64 2.44445901639344 7.82650800818272e-05 0.00127693176272332 GO:0023023 MHC protein complex binding 21/4880 37/18639 0.567567567567568 2.16780571555162 7.86380264433716e-05 0.00127693176272332 GO:0043995 histone H4K5 acetyltransferase activity 18/4880 30/18639 0.6 2.29168032786885 9.52667218101585e-05 0.00149360699481674 GO:0043996 histone H4K8 acetyltransferase activity 18/4880 30/18639 0.6 2.29168032786885 9.52667218101585e-05 0.00149360699481674 GO:0043997 histone H4K12 acetyltransferase activity 18/4880 30/18639 0.6 2.29168032786885 9.52667218101585e-05 0.00149360699481674 GO:0034212 protein N-acetyltransferase activity 27/4880 53/18639 0.509433962264151 1.94576631611506 0.000100744459883184 0.00156153912818935 GO:0010485 histone H4 acetyltransferase activity 20/4880 35/18639 0.571428571428571 2.18255269320843 0.000102147765493491 0.00156550058576542 GO:0032266 phosphatidylinositol-3-phosphate binding 25/4880 48/18639 0.520833333333333 1.98930584016393 0.000113914022882367 0.00172643030235054 GO:0003779 actin binding 151/4880 443/18639 0.340857787810384 1.30189514487659 0.000115936116095265 0.00173776771817517 GO:0036408 histone H3K14 acetyltransferase activity 17/4880 28/18639 0.607142857142857 2.31896223653396 0.000121420811741632 0.00180019551321288 GO:0016791 phosphatase activity 99/4880 273/18639 0.362637362637363 1.38508151684381 0.000139967123237902 0.00205285114082257 GO:0004896 cytokine receptor activity 42/4880 96/18639 0.4375 1.6710169057377 0.000141579769630689 0.00205441282740702 GO:0008429 phosphatidylethanolamine binding 12/4880 17/18639 0.705882352941177 2.69609450337512 0.000160823664074962 0.00230908923998156 GO:0001727 lipid kinase activity 22/4880 41/18639 0.536585365853659 2.04947021191523 0.000164715681815225 0.00234033531245799 GO:0005041 low-density lipoprotein particle receptor activity 11/4880 15/18639 0.733333333333333 2.80094262295082 0.000180083134428723 0.00253230304495648 GO:0035035 histone acetyltransferase binding 15/4880 24/18639 0.625 2.38716700819672 0.000194212894761012 0.00267582210559617 GO:0140033 acetylation-dependent protein binding 15/4880 24/18639 0.625 2.38716700819672 0.000194212894761012 0.00267582210559617 GO:0010484 histone H3 acetyltransferase activity 17/4880 29/18639 0.586206896551724 2.23899802148106 0.000221968482037043 0.00302765009498527 GO:0004402 histone acetyltransferase activity 22/4880 42/18639 0.523809523809524 2.00067330210773 0.000260804465722077 0.00352215139846448 GO:0042277 peptide binding 90/4880 249/18639 0.36144578313253 1.38053031799328 0.000311012092458439 0.00412767067970349 GO:0035591 signaling adaptor activity 52/4880 129/18639 0.403100775193798 1.53963019443385 0.000311693607045058 0.00412767067970349 GO:0016407 acetyltransferase activity 41/4880 96/18639 0.427083333333333 1.63123078893443 0.000315960694484882 0.00414394603151326 GO:0061631 ubiquitin conjugating enzyme activity 19/4880 35/18639 0.542857142857143 2.07342505854801 0.000375007475523638 0.0048715256820404 GO:0019207 kinase regulator activity 101/4880 287/18639 0.35191637630662 1.34413306106129 0.000422918544614013 0.0054420839137124 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 14/4880 23/18639 0.608695652173913 2.32489308624376 0.000471438615354549 0.00589947037929913 GO:0070577 lysine-acetylated histone binding 14/4880 23/18639 0.608695652173913 2.32489308624376 0.000471438615354549 0.00589947037929913 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 14/4880 23/18639 0.608695652173913 2.32489308624376 0.000471438615354549 0.00589947037929913 GO:0019789 SUMO transferase activity 16/4880 28/18639 0.571428571428571 2.18255269320843 0.000506143815826319 0.0062196411242081 GO:0051019 mitogen-activated protein kinase binding 16/4880 28/18639 0.571428571428571 2.18255269320843 0.000506143815826319 0.0062196411242081 GO:0001222 transcription corepressor binding 24/4880 49/18639 0.489795918367347 1.87075945132151 0.000514009679454217 0.00625990359621028 GO:0045322 unmethylated CpG binding 8/4880 10/18639 0.8 3.0555737704918 0.000583527128786443 0.00704363720057264 GO:0001223 transcription coactivator binding 22/4880 44/18639 0.5 1.90973360655738 0.000607785566375217 0.0072721009871561 GO:0005160 transforming growth factor beta receptor binding 15/4880 26/18639 0.576923076923077 2.20353877679697 0.000660100800106633 0.00776187492539179 GO:0070412 R-SMAD binding 15/4880 26/18639 0.576923076923077 2.20353877679697 0.000660100800106633 0.00776187492539179 GO:0019838 growth factor binding 53/4880 136/18639 0.389705882352941 1.48846884040501 0.000717141300424467 0.00836051909212798 GO:0005126 cytokine receptor binding 96/4880 275/18639 0.349090909090909 1.33334128166915 0.000783722677249491 0.00905930281159581 GO:0140034 methylation-dependent protein binding 33/4880 76/18639 0.434210526315789 1.65845286885246 0.000824748143906296 0.00945341569990073 GO:0042625 ATPase-coupled ion transmembrane transporter activity 14/4880 24/18639 0.583333333333333 2.22802254098361 0.000859554624185495 0.00953197160478875 GO:0043998 histone H2A acetyltransferase activity 14/4880 24/18639 0.583333333333333 2.22802254098361 0.000859554624185495 0.00953197160478875 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 14/4880 24/18639 0.583333333333333 2.22802254098361 0.000859554624185495 0.00953197160478875 GO:0046961 proton-transporting ATPase activity, rotational mechanism 14/4880 24/18639 0.583333333333333 2.22802254098361 0.000859554624185495 0.00953197160478875 GO:0140693 molecular condensate scaffold activity 23/4880 48/18639 0.479166666666667 1.83016137295082 0.000983455250329581 0.0108180077536254 GO:1990841 promoter-specific chromatin binding 30/4880 68/18639 0.441176470588235 1.68505906460945 0.00102098674505872 0.0111410073620808 GO:0002039 p53 binding 30/4880 69/18639 0.434782608695652 1.66063791874555 0.00135919502237717 0.0145979685867911 GO:0008080 N-acetyltransferase activity 30/4880 69/18639 0.434782608695652 1.66063791874555 0.00135919502237717 0.0145979685867911 GO:0031624 ubiquitin conjugating enzyme binding 16/4880 30/18639 0.533333333333333 2.03704918032787 0.00139103255684449 0.0147082822289603 GO:0032452 histone demethylase activity 16/4880 30/18639 0.533333333333333 2.03704918032787 0.00139103255684449 0.0147082822289603 GO:0005035 death receptor activity 9/4880 13/18639 0.692307692307692 2.64424653215637 0.00141374942448122 0.014720261183148 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 9/4880 13/18639 0.692307692307692 2.64424653215637 0.00141374942448122 0.014720261183148 GO:0004709 MAP kinase kinase kinase activity 14/4880 25/18639 0.56 2.13890163934426 0.00148499826997458 0.015229606317634 GO:0042974 nuclear retinoic acid receptor binding 14/4880 25/18639 0.56 2.13890163934426 0.00148499826997458 0.015229606317634 GO:0140313 molecular sequestering activity 25/4880 55/18639 0.454545454545455 1.73612146050671 0.00156352250797444 0.0159152589617697 GO:0071889 14-3-3 protein binding 17/4880 33/18639 0.515151515151515 1.9676043219076 0.0016417251943288 0.0161527830050466 GO:0140311 protein sequestering activity 17/4880 33/18639 0.515151515151515 1.9676043219076 0.0016417251943288 0.0161527830050466 GO:0005114 type II transforming growth factor beta receptor binding 8/4880 11/18639 0.727272727272727 2.77779433681073 0.00164606806283099 0.0161527830050466 GO:0008432 JUN kinase binding 8/4880 11/18639 0.727272727272727 2.77779433681073 0.00164606806283099 0.0161527830050466 GO:0048185 activin binding 8/4880 11/18639 0.727272727272727 2.77779433681073 0.00164606806283099 0.0161527830050466 GO:0004197 cysteine-type endopeptidase activity 36/4880 88/18639 0.409090909090909 1.56250931445604 0.00180772408126424 0.0176123974774602 GO:0141052 histone H3 demethylase activity 15/4880 28/18639 0.535714285714286 2.0461431498829 0.00184412459208428 0.0178396166212976 GO:0019887 protein kinase regulator activity 88/4880 255/18639 0.345098039215686 1.3180906460945 0.00186255748857066 0.0178910451719041 GO:0044013 histone H2B acetyltransferase activity 13/4880 23/18639 0.565217391304348 2.15882929436921 0.00195596041942213 0.0186568532314111 GO:0051018 protein kinase A binding 24/4880 53/18639 0.452830188679245 1.72957005876895 0.00205059197920825 0.019423662914167 GO:0019209 kinase activator activity 55/4880 148/18639 0.371621621621622 1.41939659946832 0.00208529990339809 0.0196162004705862 GO:0140457 protein demethylase activity 16/4880 31/18639 0.516129032258065 1.97133791644632 0.00218155579648366 0.0203739396981364 GO:0031593 polyubiquitin modification-dependent protein binding 26/4880 59/18639 0.440677966101695 1.68315504306752 0.00219572517274637 0.0203739396981364 GO:0038024 cargo receptor activity 28/4880 65/18639 0.430769230769231 1.64530895334174 0.0022873456457441 0.0210806720323984 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 34/4880 83/18639 0.409638554216867 1.56460102705906 0.00232400560659277 0.0212747895798157 GO:0035064 methylated histone binding 31/4880 74/18639 0.418918918918919 1.60004707576429 0.00234293686225258 0.0213051058674168 GO:0002020 protease binding 51/4880 136/18639 0.375 1.43230020491803 0.0023777699590188 0.0213326736795515 GO:0005024 transforming growth factor beta receptor activity 10/4880 16/18639 0.625 2.38716700819672 0.0023928878834101 0.0213326736795515 GO:0034450 ubiquitin-ubiquitin ligase activity 10/4880 16/18639 0.625 2.38716700819672 0.0023928878834101 0.0213326736795515 GO:0050681 nuclear androgen receptor binding 14/4880 26/18639 0.538461538461538 2.05663619167718 0.00244737865148718 0.0216767823417436 GO:0019003 GDP binding 31/4880 75/18639 0.413333333333333 1.5787131147541 0.00300639938848409 0.0264042761767714 GO:0032454 histone H3K9 demethylase activity 9/4880 14/18639 0.642857142857143 2.45537177985948 0.00303920187665184 0.0264042761767714 GO:0061665 SUMO ligase activity 9/4880 14/18639 0.642857142857143 2.45537177985948 0.00303920187665184 0.0264042761767714 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 79/4880 229/18639 0.344978165938865 1.31763279404395 0.00310485771916089 0.0268039615755408 GO:0004712 protein serine/threonine/tyrosine kinase activity 20/4880 43/18639 0.465116279069767 1.77649637819291 0.00321217118210594 0.0275559842288837 GO:0004722 protein serine/threonine phosphatase activity 40/4880 103/18639 0.388349514563107 1.48328823810282 0.00325805300614797 0.0277749018774114 GO:0030276 clathrin binding 21/4880 46/18639 0.456521739130435 1.74366981468282 0.00338606006507214 0.028686869122723 GO:0005154 epidermal growth factor receptor binding 17/4880 35/18639 0.485714285714286 1.85516978922717 0.00367289689700387 0.0309248849846498 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 8/4880 12/18639 0.666666666666667 2.54631147540984 0.00380383384520009 0.0312555985834513 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 8/4880 12/18639 0.666666666666667 2.54631147540984 0.00380383384520009 0.0312555985834513 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 8/4880 12/18639 0.666666666666667 2.54631147540984 0.00380383384520009 0.0312555985834513 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 8/4880 12/18639 0.666666666666667 2.54631147540984 0.00380383384520009 0.0312555985834513 GO:0042169 SH2 domain binding 19/4880 41/18639 0.463414634146341 1.76999700119952 0.0042434654727529 0.0324198828033793 GO:0061650 ubiquitin-like protein conjugating enzyme activity 19/4880 41/18639 0.463414634146341 1.76999700119952 0.0042434654727529 0.0324198828033793 GO:1990782 protein tyrosine kinase binding 44/4880 117/18639 0.376068376068376 1.43638083228247 0.00426981774711334 0.0324198828033793 GO:0032931 histone H3K56 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0043992 histone H3K9 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0043993 histone H3K18 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0043994 histone H3K23 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0043999 histone H2AK5 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0044012 histone H2AK9 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0044014 histone H2BK5 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0044015 histone H2BK12 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0044016 histone H3K4 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0044017 histone H3K27 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0044018 histone H3K36 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0046972 histone H4K16 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0140908 histone H3K122 acetyltransferase activity 12/4880 22/18639 0.545454545454545 2.08334575260805 0.00432582013945383 0.0324198828033793 GO:0046965 nuclear retinoid X receptor binding 10/4880 17/18639 0.588235294117647 2.24674541947927 0.00445374296032859 0.0331962043600448 GO:0001784 phosphotyrosine residue binding 21/4880 47/18639 0.446808510638298 1.70657045692361 0.00463134021752455 0.0333499197113299 GO:0005031 tumor necrosis factor receptor activity 7/4880 10/18639 0.7 2.67362704918033 0.00464551667533188 0.0333499197113299 GO:0008140 cAMP response element binding protein binding 7/4880 10/18639 0.7 2.67362704918033 0.00464551667533188 0.0333499197113299 GO:0032395 MHC class II receptor activity 7/4880 10/18639 0.7 2.67362704918033 0.00464551667533188 0.0333499197113299 GO:0051864 histone H3K36 demethylase activity 7/4880 10/18639 0.7 2.67362704918033 0.00464551667533188 0.0333499197113299 GO:0070513 death domain binding 7/4880 10/18639 0.7 2.67362704918033 0.00464551667533188 0.0333499197113299 GO:0140999 histone H3K4 trimethyltransferase activity 7/4880 10/18639 0.7 2.67362704918033 0.00464551667533188 0.0333499197113299 GO:0032813 tumor necrosis factor receptor superfamily binding 22/4880 50/18639 0.44 1.68056557377049 0.00476574020980841 0.034033872493082 GO:0140296 general transcription initiation factor binding 23/4880 53/18639 0.433962264150943 1.65750463965357 0.00486560794784489 0.0345660897961481 GO:0045309 protein phosphorylated amino acid binding 25/4880 59/18639 0.423728813559322 1.61841831064185 0.00497653919591325 0.0351709816747444 GO:0044390 ubiquitin-like protein conjugating enzyme binding 17/4880 36/18639 0.472222222222222 1.80363729508197 0.00528266637487787 0.0371420460584197 GO:0033218 amide binding 83/4880 247/18639 0.336032388663968 1.28346469104666 0.00550673732579535 0.0385189216019736 GO:0033192 calmodulin-dependent protein phosphatase activity 32/4880 81/18639 0.395061728395062 1.50892531876138 0.00591213330472591 0.0397248759982569 GO:0140791 histone H2AXS140 phosphatase activity 32/4880 81/18639 0.395061728395062 1.50892531876138 0.00591213330472591 0.0397248759982569 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 32/4880 81/18639 0.395061728395062 1.50892531876138 0.00591213330472591 0.0397248759982569 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 32/4880 81/18639 0.395061728395062 1.50892531876138 0.00591213330472591 0.0397248759982569 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 32/4880 81/18639 0.395061728395062 1.50892531876138 0.00591213330472591 0.0397248759982569 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 32/4880 81/18639 0.395061728395062 1.50892531876138 0.00591213330472591 0.0397248759982569 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 32/4880 81/18639 0.395061728395062 1.50892531876138 0.00591213330472591 0.0397248759982569 GO:1990439 MAP kinase serine/threonine phosphatase activity 32/4880 81/18639 0.395061728395062 1.50892531876138 0.00591213330472591 0.0397248759982569 GO:0042605 peptide antigen binding 20/4880 45/18639 0.444444444444444 1.69754098360656 0.00607880850279913 0.0406445823422451 GO:0038187 pattern recognition receptor activity 21/4880 48/18639 0.4375 1.6710169057377 0.00623252137007238 0.0414690690184328 GO:0030295 protein kinase activator activity 50/4880 139/18639 0.359712230215827 1.37390906946574 0.00674926133795291 0.0446892838105232 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 32/4880 82/18639 0.390243902439024 1.49052379048381 0.00730459702784643 0.0479012997403006 GO:0033549 MAP kinase phosphatase activity 32/4880 82/18639 0.390243902439024 1.49052379048381 0.00730459702784643 0.0479012997403006 GO:0043394 proteoglycan binding 17/4880 37/18639 0.459459459459459 1.75489034116083 0.00742279531788601 0.0484435062851508 GO:0017154 semaphorin receptor activity 8/4880 13/18639 0.615384615384615 2.35044136191677 0.00762796891835025 0.0488830210924662 GO:0035325 Toll-like receptor binding 8/4880 13/18639 0.615384615384615 2.35044136191677 0.00762796891835025 0.0488830210924662 GO:0070123 transforming growth factor beta receptor activity, type III 8/4880 13/18639 0.615384615384615 2.35044136191677 0.00762796891835025 0.0488830210924662 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 10/4880 18/18639 0.555555555555556 2.1219262295082 0.0076877869895837 0.0488830210924662 GO:0004706 JUN kinase kinase kinase activity 10/4880 18/18639 0.555555555555556 2.1219262295082 0.0076877869895837 0.0488830210924662 GO:0030331 nuclear estrogen receptor binding 18/4880 40/18639 0.45 1.71876024590164 0.00774100627270726 0.0488830210924662 GO:0032451 demethylase activity 18/4880 40/18639 0.45 1.71876024590164 0.00774100627270726 0.0488830210924662 GO:0034237 protein kinase A regulatory subunit binding 13/4880 26/18639 0.5 1.90973360655738 0.00788392810891631 0.0493287978924856 GO:0097602 cullin family protein binding 13/4880 26/18639 0.5 1.90973360655738 0.00788392810891631 0.0493287978924856 GO:0008375 acetylglucosaminyltransferase activity 19/4880 43/18639 0.441860465116279 1.68767155928326 0.0079801884064017 0.0494771681196905 GO:0048156 tau protein binding 19/4880 43/18639 0.441860465116279 1.68767155928326 0.0079801884064017 0.0494771681196905 GO:0016763 pentosyltransferase activity 21/4880 49/18639 0.428571428571429 1.63691451990632 0.00825999268907806 0.0509802263705994 GO:0140566 histone reader activity 16/4880 35/18639 0.457142857142857 1.74604215456674 0.00983000038515519 0.0598557049939391 GO:0016176 superoxide-generating NADPH oxidase activator activity 7/4880 11/18639 0.636363636363636 2.43057004470939 0.00989455174720846 0.0598557049939391 GO:0019864 IgG binding 7/4880 11/18639 0.636363636363636 2.43057004470939 0.00989455174720846 0.0598557049939391 GO:0032050 clathrin heavy chain binding 7/4880 11/18639 0.636363636363636 2.43057004470939 0.00989455174720846 0.0598557049939391 GO:0051219 phosphoprotein binding 35/4880 93/18639 0.376344086021505 1.43743389740878 0.00991744085676703 0.0598557049939391 GO:0004707 MAP kinase activity 9/4880 16/18639 0.5625 2.14845030737705 0.0102720305845911 0.0617226859796578 GO:0050431 transforming growth factor beta binding 12/4880 24/18639 0.5 1.90973360655738 0.0105705305815477 0.0632377355843469 GO:0043495 protein-membrane adaptor activity 20/4880 47/18639 0.425531914893617 1.62530519707011 0.0107566817788762 0.06407036657811 GO:0017018 myosin phosphatase activity 32/4880 84/18639 0.380952380952381 1.45503512880562 0.0109088081689227 0.0646939754017852 GO:0000287 magnesium ion binding 76/4880 230/18639 0.330434782608696 1.26208481824661 0.0118326658389845 0.0698690744778135 GO:0003725 double-stranded RNA binding 29/4880 75/18639 0.386666666666667 1.4768606557377 0.0118985521212503 0.0699552805749371 GO:0001968 fibronectin binding 14/4880 30/18639 0.466666666666667 1.78241803278689 0.0124217955244745 0.0726549094282707 GO:0043395 heparan sulfate proteoglycan binding 10/4880 19/18639 0.526315789473684 2.01024590163934 0.0124642586555831 0.0726549094282707 GO:0019208 phosphatase regulator activity 42/4880 117/18639 0.358974358974359 1.37109079445145 0.0127256602070831 0.0737264441192088 GO:0004713 protein tyrosine kinase activity 49/4880 140/18639 0.35 1.33681352459016 0.0127940512168456 0.0737264441192088 GO:0045296 cadherin binding 106/4880 334/18639 0.317365269461078 1.21216624128792 0.0128102399239388 0.0737264441192088 GO:0005484 SNAP receptor activity 16/4880 36/18639 0.444444444444444 1.69754098360656 0.0134678675933771 0.0771855941065811 GO:0005161 platelet-derived growth factor receptor binding 8/4880 14/18639 0.571428571428571 2.18255269320843 0.0137463249739481 0.0778007770309762 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 8/4880 14/18639 0.571428571428571 2.18255269320843 0.0137463249739481 0.0778007770309762 GO:0042813 Wnt receptor activity 8/4880 14/18639 0.571428571428571 2.18255269320843 0.0137463249739481 0.0778007770309762 GO:0046915 transition metal ion transmembrane transporter activity 19/4880 45/18639 0.422222222222222 1.61266393442623 0.014001990572189 0.0789203104977928 GO:0005178 integrin binding 55/4880 161/18639 0.341614906832298 1.30478693615721 0.0147767936145149 0.0829446357621333 GO:0031490 chromatin DNA binding 45/4880 128/18639 0.3515625 1.34278144211066 0.0151924399540322 0.0849282299069671 GO:0017025 TBP-class protein binding 12/4880 25/18639 0.48 1.83334426229508 0.0155596479981748 0.0866259586510629 GO:0015026 coreceptor activity 24/4880 61/18639 0.39344262295082 1.50274119860253 0.0166664289789531 0.0913912831745546 GO:0019905 syntaxin binding 24/4880 61/18639 0.39344262295082 1.50274119860253 0.0166664289789531 0.0913912831745546 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 9/4880 17/18639 0.529411764705882 2.02207087753134 0.0168176041618865 0.0913912831745546 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 9/4880 17/18639 0.529411764705882 2.02207087753134 0.0168176041618865 0.0913912831745546 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 9/4880 17/18639 0.529411764705882 2.02207087753134 0.0168176041618865 0.0913912831745546 GO:0019198 transmembrane receptor protein phosphatase activity 9/4880 17/18639 0.529411764705882 2.02207087753134 0.0168176041618865 0.0913912831745546 GO:0070851 growth factor receptor binding 48/4880 139/18639 0.345323741007194 1.31895270668711 0.0176605687089269 0.0955913322181599 GO:0052866 phosphatidylinositol phosphate phosphatase activity 15/4880 34/18639 0.441176470588235 1.68505906460945 0.0177793624807958 0.0958539542442901 GO:0030291 protein serine/threonine kinase inhibitor activity 19/4880 46/18639 0.41304347826087 1.57760602280827 0.0181199500250983 0.09590459346896 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 17/4880 40/18639 0.425 1.62327356557377 0.0182097069682013 0.09590459346896 GO:0005025 transforming growth factor beta receptor activity, type I 7/4880 12/18639 0.583333333333333 2.22802254098361 0.0184215568100202 0.09590459346896 GO:0005026 transforming growth factor beta receptor activity, type II 7/4880 12/18639 0.583333333333333 2.22802254098361 0.0184215568100202 0.09590459346896 GO:0005078 MAP-kinase scaffold activity 7/4880 12/18639 0.583333333333333 2.22802254098361 0.0184215568100202 0.09590459346896 GO:0016361 activin receptor activity, type I 7/4880 12/18639 0.583333333333333 2.22802254098361 0.0184215568100202 0.09590459346896 GO:0016362 activin receptor activity, type II 7/4880 12/18639 0.583333333333333 2.22802254098361 0.0184215568100202 0.09590459346896 GO:0017002 activin receptor activity 7/4880 12/18639 0.583333333333333 2.22802254098361 0.0184215568100202 0.09590459346896 GO:0035259 nuclear glucocorticoid receptor binding 7/4880 12/18639 0.583333333333333 2.22802254098361 0.0184215568100202 0.09590459346896 GO:0008234 cysteine-type peptidase activity 62/4880 187/18639 0.331550802139037 1.26634741825195 0.0197830083573835 0.102600849427647 GO:0001618 virus receptor activity 30/4880 81/18639 0.37037037037037 1.4146174863388 0.0203976104604109 0.105387654045456 GO:0019888 protein phosphatase regulator activity 38/4880 107/18639 0.355140186915888 1.35644629998468 0.0205037597054385 0.105536332974408 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 12/4880 26/18639 0.461538461538462 1.76283102143758 0.0221388364746821 0.112676764744278 GO:0008157 protein phosphatase 1 binding 12/4880 26/18639 0.461538461538462 1.76283102143758 0.0221388364746821 0.112676764744278 GO:0043548 phosphatidylinositol 3-kinase binding 12/4880 26/18639 0.461538461538462 1.76283102143758 0.0221388364746821 0.112676764744278 GO:0005518 collagen binding 27/4880 72/18639 0.375 1.43230020491803 0.0227517812193909 0.114245582525089 GO:0042809 nuclear vitamin D receptor binding 8/4880 15/18639 0.533333333333333 2.03704918032787 0.0227821102982582 0.114245582525089 GO:0061578 K63-linked deubiquitinase activity 8/4880 15/18639 0.533333333333333 2.03704918032787 0.0227821102982582 0.114245582525089 GO:0120283 protein serine/threonine kinase binding 8/4880 15/18639 0.533333333333333 2.03704918032787 0.0227821102982582 0.114245582525089 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 13/4880 29/18639 0.448275862068966 1.71217495760317 0.022972807902619 0.114779890033598 GO:0140938 histone H3 methyltransferase activity 19/4880 47/18639 0.404255319148936 1.5440399372166 0.0231164534778918 0.115076067678265 GO:0043425 bHLH transcription factor binding 14/4880 32/18639 0.4375 1.6710169057377 0.0234851394174732 0.115645235254272 GO:0071813 lipoprotein particle binding 14/4880 32/18639 0.4375 1.6710169057377 0.0234851394174732 0.115645235254272 GO:0071814 protein-lipid complex binding 14/4880 32/18639 0.4375 1.6710169057377 0.0234851394174732 0.115645235254272 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 17/4880 41/18639 0.414634146341463 1.58368152738904 0.0236861824884046 0.11621565796469 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 44/4880 128/18639 0.34375 1.3129418545082 0.0241868643901186 0.117019571583569 GO:0140272 exogenous protein binding 30/4880 82/18639 0.365853658536585 1.39736605357857 0.0242995386092351 0.117019571583569 GO:0003924 GTPase activity 103/4880 331/18639 0.311178247734139 1.18853511465504 0.0243007124533475 0.117019571583569 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 6/4880 10/18639 0.6 2.29168032786885 0.0247079447331875 0.117019571583569 GO:0004445 inositol-polyphosphate 5-phosphatase activity 6/4880 10/18639 0.6 2.29168032786885 0.0247079447331875 0.117019571583569 GO:0005381 iron ion transmembrane transporter activity 6/4880 10/18639 0.6 2.29168032786885 0.0247079447331875 0.117019571583569 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 6/4880 10/18639 0.6 2.29168032786885 0.0247079447331875 0.117019571583569 GO:0016303 1-phosphatidylinositol-3-kinase activity 6/4880 10/18639 0.6 2.29168032786885 0.0247079447331875 0.117019571583569 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 6/4880 10/18639 0.6 2.29168032786885 0.0247079447331875 0.117019571583569 GO:0043422 protein kinase B binding 6/4880 10/18639 0.6 2.29168032786885 0.0247079447331875 0.117019571583569 GO:0017075 syntaxin-1 binding 9/4880 18/18639 0.5 1.90973360655738 0.0259474213341894 0.120725578896745 GO:0034185 apolipoprotein binding 9/4880 18/18639 0.5 1.90973360655738 0.0259474213341894 0.120725578896745 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 9/4880 18/18639 0.5 1.90973360655738 0.0259474213341894 0.120725578896745 GO:0001098 basal transcription machinery binding 23/4880 60/18639 0.383333333333333 1.46412909836066 0.0260214957446064 0.120725578896745 GO:0001099 basal RNA polymerase II transcription machinery binding 23/4880 60/18639 0.383333333333333 1.46412909836066 0.0260214957446064 0.120725578896745 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 23/4880 60/18639 0.383333333333333 1.46412909836066 0.0260214957446064 0.120725578896745 GO:0005123 death receptor binding 10/4880 21/18639 0.476190476190476 1.81879391100703 0.0281637317919651 0.129344546007543 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 10/4880 21/18639 0.476190476190476 1.81879391100703 0.0281637317919651 0.129344546007543 GO:0051010 microtubule plus-end binding 10/4880 21/18639 0.476190476190476 1.81879391100703 0.0281637317919651 0.129344546007543 GO:0004715 non-membrane spanning protein tyrosine kinase activity 18/4880 45/18639 0.4 1.5277868852459 0.0297505175296954 0.136173509766794 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 7/4880 13/18639 0.538461538461538 2.05663619167718 0.0310140760169684 0.140864803691144 GO:0016409 palmitoyltransferase activity 15/4880 36/18639 0.416666666666667 1.59144467213115 0.0310796100947756 0.140864803691144 GO:0019239 deaminase activity 14/4880 33/18639 0.424242424242424 1.62038002980626 0.0311885415797108 0.140864803691144 GO:0140416 transcription regulator inhibitor activity 14/4880 33/18639 0.424242424242424 1.62038002980626 0.0311885415797108 0.140864803691144 GO:0008081 phosphoric diester hydrolase activity 31/4880 87/18639 0.35632183908046 1.36095958168457 0.0323787556722628 0.145757830815071 GO:0051015 actin filament binding 67/4880 209/18639 0.320574162679426 1.22442250372578 0.0330885592180267 0.148463140701936 GO:0004860 protein kinase inhibitor activity 30/4880 84/18639 0.357142857142857 1.36409543325527 0.033821158206926 0.151252655063105 GO:0008374 O-acyltransferase activity 21/4880 55/18639 0.381818181818182 1.45834202682563 0.0339415514146433 0.151295020031286 GO:0016410 N-acyltransferase activity 33/4880 94/18639 0.351063829787234 1.34087678758284 0.0345296084100418 0.153414937691521 GO:0030159 signaling receptor complex adaptor activity 20/4880 52/18639 0.384615384615385 1.46902585119798 0.0350631926141898 0.153939551232221 GO:0004708 MAP kinase kinase activity 8/4880 16/18639 0.5 1.90973360655738 0.0352921900119253 0.153939551232221 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 8/4880 16/18639 0.5 1.90973360655738 0.0352921900119253 0.153939551232221 GO:0070411 I-SMAD binding 8/4880 16/18639 0.5 1.90973360655738 0.0352921900119253 0.153939551232221 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 8/4880 16/18639 0.5 1.90973360655738 0.0352921900119253 0.153939551232221 GO:0030971 receptor tyrosine kinase binding 29/4880 81/18639 0.358024691358025 1.3674635701275 0.0353248383692707 0.153939551232221 GO:0042800 histone H3K4 methyltransferase activity 9/4880 19/18639 0.473684210526316 1.80922131147541 0.038082267744935 0.164902264139973 GO:0140036 ubiquitin-modified protein reader activity 9/4880 19/18639 0.473684210526316 1.80922131147541 0.038082267744935 0.164902264139973 GO:0015179 L-amino acid transmembrane transporter activity 23/4880 62/18639 0.370967741935484 1.4168991274458 0.0382247581680034 0.164995475130243 GO:0070063 RNA polymerase binding 22/4880 59/18639 0.372881355932203 1.42420811336482 0.0397362585588598 0.170141142916826 GO:0050321 tau-protein kinase activity 10/4880 22/18639 0.454545454545455 1.73612146050671 0.039791073746677 0.170141142916826 GO:0140035 ubiquitin-like protein reader activity 10/4880 22/18639 0.454545454545455 1.73612146050671 0.039791073746677 0.170141142916826 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 14/4880 34/18639 0.411764705882353 1.57272179363549 0.0405749669489512 0.172412009091494 GO:0030332 cyclin binding 14/4880 34/18639 0.411764705882353 1.57272179363549 0.0405749669489512 0.172412009091494 GO:0008483 transaminase activity 11/4880 25/18639 0.44 1.68056557377049 0.0407116328619469 0.172455488272346 GO:0005164 tumor necrosis factor receptor binding 13/4880 31/18639 0.419354838709677 1.60171205711264 0.0409715714894781 0.172833714157523 GO:0097718 disordered domain specific binding 12/4880 28/18639 0.428571428571429 1.63691451990632 0.0410543426591184 0.172833714157523 GO:0002162 dystroglycan binding 6/4880 11/18639 0.545454545454545 2.08334575260805 0.0424840163163625 0.175600600774298 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 6/4880 11/18639 0.545454545454545 2.08334575260805 0.0424840163163625 0.175600600774298 GO:0032794 GTPase activating protein binding 6/4880 11/18639 0.545454545454545 2.08334575260805 0.0424840163163625 0.175600600774298 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 6/4880 11/18639 0.545454545454545 2.08334575260805 0.0424840163163625 0.175600600774298 GO:0042608 T cell receptor binding 6/4880 11/18639 0.545454545454545 2.08334575260805 0.0424840163163625 0.175600600774298 GO:0050786 RAGE receptor binding 6/4880 11/18639 0.545454545454545 2.08334575260805 0.0424840163163625 0.175600600774298 GO:0008013 beta-catenin binding 36/4880 106/18639 0.339622641509434 1.29717754407671 0.045714907342102 0.188384089470173 GO:0098531 ligand-modulated transcription factor activity 22/4880 60/18639 0.366666666666667 1.40047131147541 0.047676384398691 0.195875266023538 GO:0004705 JUN kinase activity 7/4880 14/18639 0.5 1.90973360655738 0.0482818270599885 0.196001226517334 GO:0046030 inositol trisphosphate phosphatase activity 7/4880 14/18639 0.5 1.90973360655738 0.0482818270599885 0.196001226517334 GO:0071933 Arp2/3 complex binding 7/4880 14/18639 0.5 1.90973360655738 0.0482818270599885 0.196001226517334 GO:0098821 BMP receptor activity 7/4880 14/18639 0.5 1.90973360655738 0.0482818270599885 0.196001226517334 GO:0019783 ubiquitin-like protein peptidase activity 42/4880 127/18639 0.330708661417323 1.26313088937653 0.0498481445043489 0.201759255501282 GO:0042162 telomeric DNA binding 15/4880 38/18639 0.394736842105263 1.50768442622951 0.0504819075984476 0.203719887468292 GO:0030169 low-density lipoprotein particle binding 8/4880 17/18639 0.470588235294118 1.79739633558341 0.0517140441008486 0.206092632905122 GO:0070403 NAD+ binding 8/4880 17/18639 0.470588235294118 1.79739633558341 0.0517140441008486 0.206092632905122 GO:0003925 G protein activity 20/4880 54/18639 0.37037037037037 1.4146174863388 0.0517911677198932 0.206092632905122 GO:0140463 chromatin-protein adaptor activity 20/4880 54/18639 0.37037037037037 1.4146174863388 0.0517911677198932 0.206092632905122 GO:0050840 extracellular matrix binding 24/4880 67/18639 0.358208955223881 1.3681673599217 0.0518253468375782 0.206092632905122 GO:0016004 phospholipase activator activity 9/4880 20/18639 0.45 1.71876024590164 0.0535592624853193 0.21236870357551 GO:0016757 glycosyltransferase activity 82/4880 267/18639 0.307116104868914 1.17301989316633 0.0537238859624586 0.212404001312445 GO:0004536 DNA nuclease activity 23/4880 64/18639 0.359375 1.37262102971311 0.0542098316608879 0.212912636375088 GO:0042171 lysophosphatidic acid acyltransferase activity 10/4880 23/18639 0.434782608695652 1.66063791874555 0.054320819251122 0.212912636375088 GO:0071617 lysophospholipid acyltransferase activity 10/4880 23/18639 0.434782608695652 1.66063791874555 0.054320819251122 0.212912636375088 GO:0005525 GTP binding 113/4880 378/18639 0.298941798941799 1.14179839968774 0.0562811198737073 0.219964032973458 GO:0019001 guanyl nucleotide binding 119/4880 400/18639 0.2975 1.13629149590164 0.0580375838062013 0.225536365560281 GO:0032561 guanyl ribonucleotide binding 119/4880 400/18639 0.2975 1.13629149590164 0.0580375838062013 0.225536365560281 GO:0004843 cysteine-type deubiquitinase activity 36/4880 108/18639 0.333333333333333 1.27315573770492 0.0589676685321952 0.228499715562256 GO:0101005 deubiquitinase activity 38/4880 115/18639 0.330434782608696 1.26208481824661 0.0603856585401688 0.23333155311272 GO:0004520 DNA endonuclease activity 16/4880 42/18639 0.380952380952381 1.45503512880562 0.0605734242574829 0.233395905896064 GO:0000993 RNA polymerase II complex binding 14/4880 36/18639 0.388888888888889 1.48534836065574 0.0649813753795267 0.249674918359646 GO:0008603 cAMP-dependent protein kinase regulator activity 6/4880 12/18639 0.5 1.90973360655738 0.0665464758227047 0.250053424303497 GO:0035014 phosphatidylinositol 3-kinase regulator activity 6/4880 12/18639 0.5 1.90973360655738 0.0665464758227047 0.250053424303497 GO:0035197 siRNA binding 6/4880 12/18639 0.5 1.90973360655738 0.0665464758227047 0.250053424303497 GO:0035497 cAMP response element binding 6/4880 12/18639 0.5 1.90973360655738 0.0665464758227047 0.250053424303497 GO:0070008 serine-type exopeptidase activity 6/4880 12/18639 0.5 1.90973360655738 0.0665464758227047 0.250053424303497 GO:0097677 STAT family protein binding 6/4880 12/18639 0.5 1.90973360655738 0.0665464758227047 0.250053424303497 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 6/4880 12/18639 0.5 1.90973360655738 0.0665464758227047 0.250053424303497 GO:0141221 histone deacetylase activity, hydrolytic mechanism 6/4880 12/18639 0.5 1.90973360655738 0.0665464758227047 0.250053424303497 GO:0030296 protein tyrosine kinase activator activity 13/4880 33/18639 0.393939393939394 1.50463859910581 0.0670718024015904 0.251334995812553 GO:0051721 protein phosphatase 2A binding 12/4880 30/18639 0.4 1.5277868852459 0.0690021455077296 0.257860072527515 GO:0004879 nuclear receptor activity 21/4880 59/18639 0.355932203389831 1.35947138093915 0.0700979663390741 0.258445357497159 GO:0047372 monoacylglycerol lipase activity 7/4880 15/18639 0.466666666666667 1.78241803278689 0.0705940792265028 0.258445357497159 GO:0141050 histone H3K deacetylase activity 7/4880 15/18639 0.466666666666667 1.78241803278689 0.0705940792265028 0.258445357497159 GO:0141051 histone H4K deacetylase activity 7/4880 15/18639 0.466666666666667 1.78241803278689 0.0705940792265028 0.258445357497159 GO:0004683 calcium/calmodulin-dependent protein kinase activity 11/4880 27/18639 0.407407407407407 1.55607923497268 0.0706745735677715 0.258445357497159 GO:0005044 scavenger receptor activity 11/4880 27/18639 0.407407407407407 1.55607923497268 0.0706745735677715 0.258445357497159 GO:0005385 zinc ion transmembrane transporter activity 11/4880 27/18639 0.407407407407407 1.55607923497268 0.0706745735677715 0.258445357497159 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 11/4880 27/18639 0.407407407407407 1.55607923497268 0.0706745735677715 0.258445357497159 GO:0004622 lysophospholipase activity 10/4880 24/18639 0.416666666666667 1.59144467213115 0.0719465762005755 0.260990727292423 GO:0050699 WW domain binding 10/4880 24/18639 0.416666666666667 1.59144467213115 0.0719465762005755 0.260990727292423 GO:0015172 acidic amino acid transmembrane transporter activity 8/4880 18/18639 0.444444444444444 1.69754098360656 0.072327342314176 0.260990727292423 GO:0016854 racemase and epimerase activity 8/4880 18/18639 0.444444444444444 1.69754098360656 0.072327342314176 0.260990727292423 GO:0070064 proline-rich region binding 8/4880 18/18639 0.444444444444444 1.69754098360656 0.072327342314176 0.260990727292423 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 9/4880 21/18639 0.428571428571429 1.63691451990632 0.0726059105053349 0.261304648889912 GO:0051213 dioxygenase activity 31/4880 93/18639 0.333333333333333 1.27315573770492 0.0753630514735148 0.270513690025985 GO:0030165 PDZ domain binding 28/4880 83/18639 0.337349397590361 1.2884949634604 0.0769645339949351 0.275537071834886 GO:0019210 kinase inhibitor activity 30/4880 90/18639 0.333333333333333 1.27315573770492 0.0792181537664666 0.282862727061415 GO:0019213 deacetylase activity 14/4880 37/18639 0.378378378378378 1.44520381036774 0.0802194966176459 0.285690322157882 GO:0097110 scaffold protein binding 24/4880 70/18639 0.342857142857143 1.30953161592506 0.0820246191193403 0.291358282496823 GO:1902936 phosphatidylinositol bisphosphate binding 36/4880 111/18639 0.324324324324324 1.23874612317235 0.0837201206460152 0.296608427431597 GO:0008327 methyl-CpG binding 12/4880 31/18639 0.387096774193548 1.47850343733474 0.0867056659403094 0.305598264451116 GO:0070273 phosphatidylinositol-4-phosphate binding 12/4880 31/18639 0.387096774193548 1.47850343733474 0.0867056659403094 0.305598264451116 GO:0016790 thiolester hydrolase activity 16/4880 44/18639 0.363636363636364 1.38889716840537 0.0888265289966116 0.310853264768626 GO:0035401 histone H3Y41 kinase activity 37/4880 115/18639 0.321739130434783 1.2288720598717 0.08888033230188 0.310853264768626 GO:0140801 histone H2AXY142 kinase activity 37/4880 115/18639 0.321739130434783 1.2288720598717 0.08888033230188 0.310853264768626 GO:0015101 organic cation transmembrane transporter activity 27/4880 81/18639 0.333333333333333 1.27315573770492 0.0921887951902832 0.315556371771017 GO:0004090 carbonyl reductase (NADPH) activity 5/4880 10/18639 0.5 1.90973360655738 0.0926362396096932 0.315556371771017 GO:0004382 GDP phosphatase activity 5/4880 10/18639 0.5 1.90973360655738 0.0926362396096932 0.315556371771017 GO:0004862 cAMP-dependent protein kinase inhibitor activity 5/4880 10/18639 0.5 1.90973360655738 0.0926362396096932 0.315556371771017 GO:0005131 growth hormone receptor binding 5/4880 10/18639 0.5 1.90973360655738 0.0926362396096932 0.315556371771017 GO:0008239 dipeptidyl-peptidase activity 5/4880 10/18639 0.5 1.90973360655738 0.0926362396096932 0.315556371771017 GO:0042975 peroxisome proliferator activated receptor binding 5/4880 10/18639 0.5 1.90973360655738 0.0926362396096932 0.315556371771017 GO:0099122 RNA polymerase II C-terminal domain binding 5/4880 10/18639 0.5 1.90973360655738 0.0926362396096932 0.315556371771017 GO:1905394 retromer complex binding 5/4880 10/18639 0.5 1.90973360655738 0.0926362396096932 0.315556371771017 GO:0008139 nuclear localization sequence binding 10/4880 25/18639 0.4 1.5277868852459 0.0927698717596611 0.315556371771017 GO:0015296 monoatomic anion:monoatomic cation symporter activity 10/4880 25/18639 0.4 1.5277868852459 0.0927698717596611 0.315556371771017 GO:0004407 histone deacetylase activity 9/4880 22/18639 0.409090909090909 1.56250931445604 0.0953238744151752 0.320250651976106 GO:0015377 chloride:monoatomic cation symporter activity 9/4880 22/18639 0.409090909090909 1.56250931445604 0.0953238744151752 0.320250651976106 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 9/4880 22/18639 0.409090909090909 1.56250931445604 0.0953238744151752 0.320250651976106 GO:0033558 protein lysine deacetylase activity 9/4880 22/18639 0.409090909090909 1.56250931445604 0.0953238744151752 0.320250651976106 GO:0033691 sialic acid binding 9/4880 22/18639 0.409090909090909 1.56250931445604 0.0953238744151752 0.320250651976106 GO:0032396 inhibitory MHC class I receptor activity 6/4880 13/18639 0.461538461538462 1.76283102143758 0.097002818513336 0.323047599249955 GO:0015245 fatty acid transmembrane transporter activity 8/4880 19/18639 0.421052631578947 1.60819672131148 0.097232851091806 0.323047599249955 GO:1990380 K48-linked deubiquitinase activity 8/4880 19/18639 0.421052631578947 1.60819672131148 0.097232851091806 0.323047599249955 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 7/4880 16/18639 0.4375 1.6710169057377 0.0980511041711741 0.323047599249955 GO:0005324 long-chain fatty acid transmembrane transporter activity 7/4880 16/18639 0.4375 1.6710169057377 0.0980511041711741 0.323047599249955 GO:0031435 mitogen-activated protein kinase kinase kinase binding 7/4880 16/18639 0.4375 1.6710169057377 0.0980511041711741 0.323047599249955 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 7/4880 16/18639 0.4375 1.6710169057377 0.0980511041711741 0.323047599249955 GO:0097027 ubiquitin-protein transferase activator activity 7/4880 16/18639 0.4375 1.6710169057377 0.0980511041711741 0.323047599249955 GO:0016298 lipase activity 41/4880 130/18639 0.315384615384615 1.20460119798235 0.0994055049681553 0.326720744039913 GO:0043175 RNA polymerase core enzyme binding 15/4880 42/18639 0.357142857142857 1.36409543325527 0.111182176779075 0.362398129986419 GO:0050660 flavin adenine dinucleotide binding 28/4880 86/18639 0.325581395348837 1.24354746473504 0.111748907969374 0.362398129986419 GO:0004629 phospholipase C activity 11/4880 29/18639 0.379310344827586 1.44876342566422 0.111854554783198 0.362398129986419 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 11/4880 29/18639 0.379310344827586 1.44876342566422 0.111854554783198 0.362398129986419 GO:0051861 glycolipid binding 11/4880 29/18639 0.379310344827586 1.44876342566422 0.111854554783198 0.362398129986419 GO:0097472 cyclin-dependent protein kinase activity 11/4880 29/18639 0.379310344827586 1.44876342566422 0.111854554783198 0.362398129986419 GO:0001786 phosphatidylserine binding 20/4880 59/18639 0.338983050847458 1.29473464851348 0.116254201653513 0.374735273591942 GO:0001637 G protein-coupled chemoattractant receptor activity 10/4880 26/18639 0.384615384615385 1.46902585119798 0.116793739393236 0.374735273591942 GO:0004950 chemokine receptor activity 10/4880 26/18639 0.384615384615385 1.46902585119798 0.116793739393236 0.374735273591942 GO:0019865 immunoglobulin binding 10/4880 26/18639 0.384615384615385 1.46902585119798 0.116793739393236 0.374735273591942 GO:0016776 phosphotransferase activity, phosphate group as acceptor 14/4880 39/18639 0.358974358974359 1.37109079445145 0.117036089846164 0.374735273591942 GO:0035254 glutamate receptor binding 17/4880 49/18639 0.346938775510204 1.3251212780194 0.117791557869781 0.376270924904873 GO:0004602 glutathione peroxidase activity 9/4880 23/18639 0.391304347826087 1.49457412687099 0.121682981306352 0.386889479025324 GO:0043274 phospholipase binding 9/4880 23/18639 0.391304347826087 1.49457412687099 0.121682981306352 0.386889479025324 GO:0048306 calcium-dependent protein binding 26/4880 80/18639 0.325 1.2413268442623 0.123990150812259 0.393308292344003 GO:0015095 magnesium ion transmembrane transporter activity 8/4880 20/18639 0.4 1.5277868852459 0.126348576829464 0.399859533167954 GO:1901505 carbohydrate derivative transmembrane transporter activity 18/4880 53/18639 0.339622641509434 1.29717754407671 0.129518385166943 0.403881478643996 GO:0019956 chemokine binding 12/4880 33/18639 0.363636363636364 1.38889716840537 0.129765013318496 0.403881478643996 GO:0008484 sulfuric ester hydrolase activity 7/4880 17/18639 0.411764705882353 1.57272179363549 0.130487046220402 0.403881478643996 GO:0017110 nucleoside diphosphate phosphatase activity 7/4880 17/18639 0.411764705882353 1.57272179363549 0.130487046220402 0.403881478643996 GO:0036041 long-chain fatty acid binding 7/4880 17/18639 0.411764705882353 1.57272179363549 0.130487046220402 0.403881478643996 GO:1990226 histone methyltransferase binding 7/4880 17/18639 0.411764705882353 1.57272179363549 0.130487046220402 0.403881478643996 GO:0030246 carbohydrate binding 82/4880 280/18639 0.292857142857143 1.11855825526932 0.131444890041079 0.403881478643996 GO:0005545 1-phosphatidylinositol binding 6/4880 14/18639 0.428571428571429 1.63691451990632 0.133543562103346 0.403881478643996 GO:0008474 palmitoyl-(protein) hydrolase activity 6/4880 14/18639 0.428571428571429 1.63691451990632 0.133543562103346 0.403881478643996 GO:0019763 immunoglobulin receptor activity 6/4880 14/18639 0.428571428571429 1.63691451990632 0.133543562103346 0.403881478643996 GO:0034236 protein kinase A catalytic subunit binding 6/4880 14/18639 0.428571428571429 1.63691451990632 0.133543562103346 0.403881478643996 GO:0042043 neurexin family protein binding 6/4880 14/18639 0.428571428571429 1.63691451990632 0.133543562103346 0.403881478643996 GO:0098599 palmitoyl hydrolase activity 6/4880 14/18639 0.428571428571429 1.63691451990632 0.133543562103346 0.403881478643996 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0019215 intermediate filament binding 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0034713 type I transforming growth factor beta receptor binding 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0097493 structural molecule activity conferring elasticity 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0140031 phosphorylation-dependent protein binding 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0180030 inositol phosphate kinase activity 5/4880 11/18639 0.454545454545455 1.73612146050671 0.134429759020802 0.403881478643996 GO:0016769 transferase activity, transferring nitrogenous groups 11/4880 30/18639 0.366666666666667 1.40047131147541 0.136663844363733 0.409691172993695 GO:0061791 GTPase motor activity 14/4880 40/18639 0.35 1.33681352459016 0.138600315408515 0.412774738465534 GO:0071949 FAD binding 14/4880 40/18639 0.35 1.33681352459016 0.138600315408515 0.412774738465534 GO:1990606 membrane scission GTPase motor activity 14/4880 40/18639 0.35 1.33681352459016 0.138600315408515 0.412774738465534 GO:0004857 enzyme inhibitor activity 119/4880 416/18639 0.286057692307692 1.0925879768285 0.140123748465594 0.416402598926077 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 10/4880 27/18639 0.37037037037037 1.4146174863388 0.143922660467039 0.426761975819655 GO:0052689 carboxylic ester hydrolase activity 29/4880 92/18639 0.315217391304348 1.20396249109052 0.147330279390236 0.435918657458312 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 18/4880 54/18639 0.333333333333333 1.27315573770492 0.148883647340195 0.437666583991434 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 18/4880 54/18639 0.333333333333333 1.27315573770492 0.148883647340195 0.437666583991434 GO:0051287 NAD binding 18/4880 54/18639 0.333333333333333 1.27315573770492 0.148883647340195 0.437666583991434 GO:0001091 RNA polymerase II general transcription initiation factor binding 9/4880 24/18639 0.375 1.43230020491803 0.151524824369818 0.441623633419727 GO:0005315 phosphate transmembrane transporter activity 9/4880 24/18639 0.375 1.43230020491803 0.151524824369818 0.441623633419727 GO:0015295 solute:proton symporter activity 9/4880 24/18639 0.375 1.43230020491803 0.151524824369818 0.441623633419727 GO:0060229 lipase activator activity 9/4880 24/18639 0.375 1.43230020491803 0.151524824369818 0.441623633419727 GO:0001046 core promoter sequence-specific DNA binding 15/4880 44/18639 0.340909090909091 1.30209109538003 0.153119614481822 0.443429202023789 GO:0019205 nucleobase-containing compound kinase activity 15/4880 44/18639 0.340909090909091 1.30209109538003 0.153119614481822 0.443429202023789 GO:0043014 alpha-tubulin binding 15/4880 44/18639 0.340909090909091 1.30209109538003 0.153119614481822 0.443429202023789 GO:0032934 sterol binding 22/4880 68/18639 0.323529411764706 1.2357099807136 0.153532781628253 0.443683716400292 GO:0015631 tubulin binding 110/4880 385/18639 0.285714285714286 1.09127634660422 0.154096917169929 0.444372505327236 GO:0009931 calcium-dependent protein serine/threonine kinase activity 8/4880 21/18639 0.380952380952381 1.45503512880562 0.159420986875081 0.456828206087418 GO:0010314 phosphatidylinositol-5-phosphate binding 8/4880 21/18639 0.380952380952381 1.45503512880562 0.159420986875081 0.456828206087418 GO:0140312 cargo adaptor activity 8/4880 21/18639 0.380952380952381 1.45503512880562 0.159420986875081 0.456828206087418 GO:0061980 regulatory RNA binding 19/4880 58/18639 0.327586206896552 1.25120477671001 0.160414993602863 0.458712895753262 GO:0016209 antioxidant activity 27/4880 86/18639 0.313953488372093 1.19913505528021 0.163369991334141 0.465463844418676 GO:0033293 monocarboxylic acid binding 25/4880 79/18639 0.316455696202532 1.20869215604897 0.163498995646695 0.465463844418676 GO:0016411 acylglycerol O-acyltransferase activity 11/4880 31/18639 0.354838709677419 1.35529481755685 0.164140842496615 0.465463844418676 GO:0017147 Wnt-protein binding 11/4880 31/18639 0.354838709677419 1.35529481755685 0.164140842496615 0.465463844418676 GO:0000900 mRNA regulatory element binding translation repressor activity 7/4880 18/18639 0.388888888888889 1.48534836065574 0.167497766888 0.472039161229819 GO:0032393 MHC class I receptor activity 7/4880 18/18639 0.388888888888889 1.48534836065574 0.167497766888 0.472039161229819 GO:0050811 GABA receptor binding 7/4880 18/18639 0.388888888888889 1.48534836065574 0.167497766888 0.472039161229819 GO:0042887 amide transmembrane transporter activity 13/4880 38/18639 0.342105263157895 1.30665983606557 0.171976791915849 0.483662565305605 GO:0051959 dynein light intermediate chain binding 10/4880 28/18639 0.357142857142857 1.36409543325527 0.173968246653064 0.48725398035889 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 10/4880 28/18639 0.357142857142857 1.36409543325527 0.173968246653064 0.48725398035889 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 6/4880 15/18639 0.4 1.5277868852459 0.175509884021242 0.488562207765253 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 6/4880 15/18639 0.4 1.5277868852459 0.175509884021242 0.488562207765253 GO:0015929 hexosaminidase activity 6/4880 15/18639 0.4 1.5277868852459 0.175509884021242 0.488562207765253 GO:0031406 carboxylic acid binding 55/4880 187/18639 0.294117647058824 1.12337270973963 0.176646804331063 0.490725541970611 GO:0004126 cytidine deaminase activity 5/4880 12/18639 0.416666666666667 1.59144467213115 0.182917818448015 0.49999980834287 GO:0004875 complement receptor activity 5/4880 12/18639 0.416666666666667 1.59144467213115 0.182917818448015 0.49999980834287 GO:0005165 neurotrophin receptor binding 5/4880 12/18639 0.416666666666667 1.59144467213115 0.182917818448015 0.49999980834287 GO:0005247 voltage-gated chloride channel activity 5/4880 12/18639 0.416666666666667 1.59144467213115 0.182917818448015 0.49999980834287 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 5/4880 12/18639 0.416666666666667 1.59144467213115 0.182917818448015 0.49999980834287 GO:0070410 co-SMAD binding 5/4880 12/18639 0.416666666666667 1.59144467213115 0.182917818448015 0.49999980834287 GO:0070679 inositol 1,4,5 trisphosphate binding 5/4880 12/18639 0.416666666666667 1.59144467213115 0.182917818448015 0.49999980834287 GO:1990459 transferrin receptor binding 5/4880 12/18639 0.416666666666667 1.59144467213115 0.182917818448015 0.49999980834287 GO:0000030 mannosyltransferase activity 9/4880 25/18639 0.36 1.37500819672131 0.184574485213031 0.500322890107592 GO:0003707 nuclear steroid receptor activity 9/4880 25/18639 0.36 1.37500819672131 0.184574485213031 0.500322890107592 GO:0019706 protein-cysteine S-palmitoyltransferase activity 9/4880 25/18639 0.36 1.37500819672131 0.184574485213031 0.500322890107592 GO:0019707 protein-cysteine S-acyltransferase activity 9/4880 25/18639 0.36 1.37500819672131 0.184574485213031 0.500322890107592 GO:0016798 hydrolase activity, acting on glycosyl bonds 39/4880 130/18639 0.3 1.14584016393443 0.184870041506031 0.500322890107592 GO:0019894 kinesin binding 14/4880 42/18639 0.333333333333333 1.27315573770492 0.187692590468799 0.50495600276024 GO:0035198 miRNA binding 14/4880 42/18639 0.333333333333333 1.27315573770492 0.187692590468799 0.50495600276024 GO:0048487 beta-tubulin binding 14/4880 42/18639 0.333333333333333 1.27315573770492 0.187692590468799 0.50495600276024 GO:0072341 modified amino acid binding 28/4880 91/18639 0.307692307692308 1.17522068095839 0.188662998184862 0.506567577803448 GO:0051087 protein-folding chaperone binding 40/4880 134/18639 0.298507462686567 1.14013946660142 0.19083649167408 0.511396806765119 GO:0004620 phospholipase activity 33/4880 109/18639 0.302752293577982 1.15635245901639 0.192109073932102 0.513797601653701 GO:0005507 copper ion binding 20/4880 63/18639 0.317460317460317 1.21252927400468 0.192486038846559 0.513798350267528 GO:0015291 secondary active transmembrane transporter activity 82/4880 287/18639 0.285714285714286 1.09127634660422 0.194026374995627 0.516056752271808 GO:0051059 NF-kappaB binding 11/4880 32/18639 0.34375 1.3129418545082 0.194088793193136 0.516056752271808 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 13/4880 39/18639 0.333333333333333 1.27315573770492 0.199447142950692 0.529272184795222 GO:0043177 organic acid binding 55/4880 189/18639 0.291005291005291 1.11148516783763 0.200948492533265 0.532220861777423 GO:0042054 histone methyltransferase activity 21/4880 67/18639 0.313432835820896 1.19714643993149 0.203073780743491 0.53680743591884 GO:0004864 protein phosphatase inhibitor activity 17/4880 53/18639 0.320754716981132 1.22511212496134 0.203530880077915 0.536975087865138 GO:0016417 S-acyltransferase activity 10/4880 29/18639 0.344827586206897 1.31705765969474 0.206659663426678 0.542310825893932 GO:0043236 laminin binding 10/4880 29/18639 0.344827586206897 1.31705765969474 0.206659663426678 0.542310825893932 GO:0043178 alcohol binding 28/4880 92/18639 0.304347826086957 1.16244654312188 0.206746062657511 0.542310825893932 GO:0050145 nucleoside monophosphate kinase activity 7/4880 19/18639 0.368421052631579 1.40717213114754 0.20848563443578 0.543736912754119 GO:0097001 ceramide binding 7/4880 19/18639 0.368421052631579 1.40717213114754 0.20848563443578 0.543736912754119 GO:0120227 acyl-CoA binding 7/4880 19/18639 0.368421052631579 1.40717213114754 0.20848563443578 0.543736912754119 GO:0004435 phosphatidylinositol phospholipase C activity 9/4880 26/18639 0.346153846153846 1.32212326607818 0.22045840947057 0.568082077362607 GO:0050750 low-density lipoprotein particle receptor binding 9/4880 26/18639 0.346153846153846 1.32212326607818 0.22045840947057 0.568082077362607 GO:0000062 fatty-acyl-CoA binding 6/4880 16/18639 0.375 1.43230020491803 0.221985151931283 0.568082077362607 GO:0005149 interleukin-1 receptor binding 6/4880 16/18639 0.375 1.43230020491803 0.221985151931283 0.568082077362607 GO:0005159 insulin-like growth factor receptor binding 6/4880 16/18639 0.375 1.43230020491803 0.221985151931283 0.568082077362607 GO:0005521 lamin binding 6/4880 16/18639 0.375 1.43230020491803 0.221985151931283 0.568082077362607 GO:0015923 mannosidase activity 6/4880 16/18639 0.375 1.43230020491803 0.221985151931283 0.568082077362607 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 6/4880 16/18639 0.375 1.43230020491803 0.221985151931283 0.568082077362607 GO:0022858 alanine transmembrane transporter activity 6/4880 16/18639 0.375 1.43230020491803 0.221985151931283 0.568082077362607 GO:0030275 LRR domain binding 6/4880 16/18639 0.375 1.43230020491803 0.221985151931283 0.568082077362607 GO:0015485 cholesterol binding 17/4880 54/18639 0.314814814814815 1.20242486338798 0.228639068092544 0.583511748730639 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 26/4880 86/18639 0.302325581395349 1.15472264582539 0.22893323380299 0.583511748730639 GO:0005504 fatty acid binding 15/4880 47/18639 0.319148936170213 1.21897889780258 0.229297871935207 0.583511748730639 GO:0008017 microtubule binding 78/4880 276/18639 0.282608695652174 1.0794146471846 0.233411943947858 0.590022745534563 GO:0005158 insulin receptor binding 8/4880 23/18639 0.347826086956522 1.32851033499644 0.235709202667083 0.590022745534563 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 8/4880 23/18639 0.347826086956522 1.32851033499644 0.235709202667083 0.590022745534563 GO:0004535 poly(A)-specific ribonuclease activity 5/4880 13/18639 0.384615384615385 1.46902585119798 0.236614693407189 0.590022745534563 GO:0008035 high-density lipoprotein particle binding 5/4880 13/18639 0.384615384615385 1.46902585119798 0.236614693407189 0.590022745534563 GO:0035673 oligopeptide transmembrane transporter activity 5/4880 13/18639 0.384615384615385 1.46902585119798 0.236614693407189 0.590022745534563 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 5/4880 13/18639 0.384615384615385 1.46902585119798 0.236614693407189 0.590022745534563 GO:0046974 histone H3K9 methyltransferase activity 5/4880 13/18639 0.384615384615385 1.46902585119798 0.236614693407189 0.590022745534563 GO:0051011 microtubule minus-end binding 5/4880 13/18639 0.384615384615385 1.46902585119798 0.236614693407189 0.590022745534563 GO:0089720 caspase binding 5/4880 13/18639 0.384615384615385 1.46902585119798 0.236614693407189 0.590022745534563 GO:0140852 histone ubiquitin ligase activity 5/4880 13/18639 0.384615384615385 1.46902585119798 0.236614693407189 0.590022745534563 GO:0160215 deacylase activity 20/4880 65/18639 0.307692307692308 1.17522068095839 0.238057778805315 0.592537974982571 GO:0035925 mRNA 3'-UTR AU-rich region binding 10/4880 30/18639 0.333333333333333 1.27315573770492 0.241657572958151 0.600402421702946 GO:0042805 actinin binding 12/4880 37/18639 0.324324324324324 1.23874612317235 0.243795846480443 0.6046136992715 GO:0008194 UDP-glycosyltransferase activity 42/4880 145/18639 0.289655172413793 1.10632843414358 0.248665612688853 0.60473844748183 GO:0004955 prostaglandin receptor activity 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0031434 mitogen-activated protein kinase kinase binding 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0071723 lipopeptide binding 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:1990757 ubiquitin ligase activator activity 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:1990763 arrestin family protein binding 4/4880 10/18639 0.4 1.5277868852459 0.252310454767517 0.60473844748183 GO:0001614 purinergic nucleotide receptor activity 7/4880 20/18639 0.35 1.33681352459016 0.252713280839181 0.60473844748183 GO:0001972 retinoic acid binding 7/4880 20/18639 0.35 1.33681352459016 0.252713280839181 0.60473844748183 GO:0016502 nucleotide receptor activity 7/4880 20/18639 0.35 1.33681352459016 0.252713280839181 0.60473844748183 GO:0052745 inositol phosphate phosphatase activity 7/4880 20/18639 0.35 1.33681352459016 0.252713280839181 0.60473844748183 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 15/4880 48/18639 0.3125 1.19358350409836 0.257691744005992 0.615571871846188 GO:0004364 glutathione transferase activity 9/4880 27/18639 0.333333333333333 1.27315573770492 0.258726283972335 0.615885953469922 GO:0035255 ionotropic glutamate receptor binding 9/4880 27/18639 0.333333333333333 1.27315573770492 0.258726283972335 0.615885953469922 GO:0016831 carboxy-lyase activity 11/4880 34/18639 0.323529411764706 1.2357099807136 0.260320244862005 0.618600721240025 GO:0015293 symporter activity 42/4880 146/18639 0.287671232876712 1.0987508421289 0.265047976741076 0.628739896130136 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 18/4880 59/18639 0.305084745762712 1.16526118366213 0.266565188546084 0.631241175654268 GO:0005080 protein kinase C binding 16/4880 52/18639 0.307692307692308 1.17522068095839 0.270509098759161 0.63503824979994 GO:0004550 nucleoside diphosphate kinase activity 6/4880 17/18639 0.352941176470588 1.34804725168756 0.271893209591763 0.63503824979994 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/4880 17/18639 0.352941176470588 1.34804725168756 0.271893209591763 0.63503824979994 GO:0015278 intracellularly gated calcium channel activity 6/4880 17/18639 0.352941176470588 1.34804725168756 0.271893209591763 0.63503824979994 GO:0016805 dipeptidase activity 6/4880 17/18639 0.352941176470588 1.34804725168756 0.271893209591763 0.63503824979994 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 6/4880 17/18639 0.352941176470588 1.34804725168756 0.271893209591763 0.63503824979994 GO:0031489 myosin V binding 6/4880 17/18639 0.352941176470588 1.34804725168756 0.271893209591763 0.63503824979994 GO:1901567 fatty acid derivative binding 6/4880 17/18639 0.352941176470588 1.34804725168756 0.271893209591763 0.63503824979994 GO:0008009 chemokine activity 14/4880 45/18639 0.311111111111111 1.18827868852459 0.274069100024437 0.637935584357223 GO:0141110 transporter inhibitor activity 14/4880 45/18639 0.311111111111111 1.18827868852459 0.274069100024437 0.637935584357223 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 8/4880 24/18639 0.333333333333333 1.27315573770492 0.277801391815716 0.639679952165192 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 8/4880 24/18639 0.333333333333333 1.27315573770492 0.277801391815716 0.639679952165192 GO:0019957 C-C chemokine binding 8/4880 24/18639 0.333333333333333 1.27315573770492 0.277801391815716 0.639679952165192 GO:0030552 cAMP binding 8/4880 24/18639 0.333333333333333 1.27315573770492 0.277801391815716 0.639679952165192 GO:0070300 phosphatidic acid binding 8/4880 24/18639 0.333333333333333 1.27315573770492 0.277801391815716 0.639679952165192 GO:0070840 dynein complex binding 8/4880 24/18639 0.333333333333333 1.27315573770492 0.277801391815716 0.639679952165192 GO:0070325 lipoprotein particle receptor binding 10/4880 31/18639 0.32258064516129 1.23208619777895 0.278570301749358 0.639679952165192 GO:0072349 modified amino acid transmembrane transporter activity 10/4880 31/18639 0.32258064516129 1.23208619777895 0.278570301749358 0.639679952165192 GO:0031491 nucleosome binding 22/4880 74/18639 0.297297297297297 1.13551727957466 0.281940302918641 0.64632759735533 GO:0019212 phosphatase inhibitor activity 17/4880 56/18639 0.303571428571429 1.15948111826698 0.282412938433854 0.64632759735533 GO:0060590 ATPase regulator activity 15/4880 49/18639 0.306122448979592 1.16922465707595 0.287287414627913 0.656381965749536 GO:0019199 transmembrane receptor protein kinase activity 23/4880 78/18639 0.294871794871795 1.12625315258512 0.2909728033816 0.663690474602847 GO:0008191 metalloendopeptidase inhibitor activity 5/4880 14/18639 0.357142857142857 1.36409543325527 0.293876433020435 0.664755314493985 GO:0015386 potassium:proton antiporter activity 5/4880 14/18639 0.357142857142857 1.36409543325527 0.293876433020435 0.664755314493985 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 5/4880 14/18639 0.357142857142857 1.36409543325527 0.293876433020435 0.664755314493985 GO:0070742 C2H2 zinc finger domain binding 5/4880 14/18639 0.357142857142857 1.36409543325527 0.293876433020435 0.664755314493985 GO:1901612 cardiolipin binding 5/4880 14/18639 0.357142857142857 1.36409543325527 0.293876433020435 0.664755314493985 GO:0046875 ephrin receptor binding 9/4880 28/18639 0.321428571428571 1.22768588992974 0.298874827965674 0.670486468880395 GO:0050698 proteoglycan sulfotransferase activity 9/4880 28/18639 0.321428571428571 1.22768588992974 0.298874827965674 0.670486468880395 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 7/4880 21/18639 0.333333333333333 1.27315573770492 0.299359427821232 0.670486468880395 GO:0008373 sialyltransferase activity 7/4880 21/18639 0.333333333333333 1.27315573770492 0.299359427821232 0.670486468880395 GO:0015174 basic amino acid transmembrane transporter activity 7/4880 21/18639 0.333333333333333 1.27315573770492 0.299359427821232 0.670486468880395 GO:0035613 RNA stem-loop binding 7/4880 21/18639 0.333333333333333 1.27315573770492 0.299359427821232 0.670486468880395 GO:0016504 peptidase activator activity 17/4880 57/18639 0.298245614035088 1.1391393442623 0.310765438164914 0.694891897798267 GO:0030145 manganese ion binding 20/4880 68/18639 0.294117647058824 1.12337270973963 0.313683680142745 0.697649668140419 GO:0120015 sterol transfer activity 10/4880 32/18639 0.3125 1.19358350409836 0.316970987456731 0.697649668140419 GO:0015605 organophosphate ester transmembrane transporter activity 15/4880 50/18639 0.3 1.14584016393443 0.317878098382631 0.697649668140419 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0003953 NAD+ nucleosidase activity 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0004954 prostanoid receptor activity 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0008199 ferric iron binding 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0019107 myristoyltransferase activity 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0019203 carbohydrate phosphatase activity 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0034056 estrogen response element binding 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0043522 leucine zipper domain binding 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0045294 alpha-catenin binding 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0047676 arachidonate-CoA ligase activity 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0140537 transcription regulator activator activity 4/4880 11/18639 0.363636363636364 1.38889716840537 0.319670852337069 0.697649668140419 GO:0015294 solute:monoatomic cation symporter activity 33/4880 116/18639 0.28448275862069 1.08657256924816 0.321289022385681 0.70006106475091 GO:0003774 cytoskeletal motor activity 43/4880 153/18639 0.281045751633987 1.07344503375121 0.321954127478623 0.700391435216654 GO:0008409 5'-3' exonuclease activity 6/4880 18/18639 0.333333333333333 1.27315573770492 0.324090930943645 0.701682586995447 GO:0035615 clathrin adaptor activity 6/4880 18/18639 0.333333333333333 1.27315573770492 0.324090930943645 0.701682586995447 GO:0098641 cadherin binding involved in cell-cell adhesion 6/4880 18/18639 0.333333333333333 1.27315573770492 0.324090930943645 0.701682586995447 GO:0031072 heat shock protein binding 37/4880 131/18639 0.282442748091603 1.07878081591791 0.325791962438126 0.704247601847232 GO:0050661 NADP binding 16/4880 54/18639 0.296296296296296 1.13169398907104 0.329297320021774 0.710698646376107 GO:0015297 antiporter activity 38/4880 135/18639 0.281481481481481 1.07510928961749 0.331493465901786 0.714308195086944 GO:0008238 exopeptidase activity 29/4880 102/18639 0.284313725490196 1.08592695274831 0.337281863134701 0.725634797027969 GO:0016279 protein-lysine N-methyltransferase activity 20/4880 69/18639 0.289855072463768 1.10709194583036 0.340345277465518 0.731072375532231 GO:0004177 aminopeptidase activity 12/4880 40/18639 0.3 1.14584016393443 0.346803745723629 0.743083832998432 GO:0031683 G-protein beta/gamma-subunit complex binding 7/4880 22/18639 0.318181818181818 1.21528502235469 0.34757147027346 0.743083832998432 GO:0140517 protein-RNA adaptor activity 7/4880 22/18639 0.318181818181818 1.21528502235469 0.34757147027346 0.743083832998432 GO:0043539 protein serine/threonine kinase activator activity 21/4880 73/18639 0.287671232876712 1.0987508421289 0.349040618775557 0.744317528682107 GO:0005048 signal sequence binding 15/4880 51/18639 0.294117647058824 1.12337270973963 0.349245704064138 0.744317528682107 GO:0004559 alpha-mannosidase activity 5/4880 15/18639 0.333333333333333 1.27315573770492 0.353059707520032 0.744317528682107 GO:0004953 icosanoid receptor activity 5/4880 15/18639 0.333333333333333 1.27315573770492 0.353059707520032 0.744317528682107 GO:0005402 carbohydrate:monoatomic cation symporter activity 5/4880 15/18639 0.333333333333333 1.27315573770492 0.353059707520032 0.744317528682107 GO:0015556 C4-dicarboxylate transmembrane transporter activity 5/4880 15/18639 0.333333333333333 1.27315573770492 0.353059707520032 0.744317528682107 GO:0017081 chloride channel regulator activity 5/4880 15/18639 0.333333333333333 1.27315573770492 0.353059707520032 0.744317528682107 GO:0050700 CARD domain binding 5/4880 15/18639 0.333333333333333 1.27315573770492 0.353059707520032 0.744317528682107 GO:0051371 muscle alpha-actinin binding 5/4880 15/18639 0.333333333333333 1.27315573770492 0.353059707520032 0.744317528682107 GO:0016248 channel inhibitor activity 13/4880 44/18639 0.295454545454545 1.12847894932936 0.359376694123549 0.75615883349036 GO:0098632 cell-cell adhesion mediator activity 16/4880 55/18639 0.290909090909091 1.11111773472429 0.3597852514188 0.75615883349036 GO:0004112 cyclic-nucleotide phosphodiesterase activity 8/4880 26/18639 0.307692307692308 1.17522068095839 0.366657085189239 0.767055619935771 GO:0008198 ferrous iron binding 8/4880 26/18639 0.307692307692308 1.17522068095839 0.366657085189239 0.767055619935771 GO:0030247 polysaccharide binding 8/4880 26/18639 0.307692307692308 1.17522068095839 0.366657085189239 0.767055619935771 GO:0016278 lysine N-methyltransferase activity 20/4880 70/18639 0.285714285714286 1.09127634660422 0.367509094860638 0.767660651439373 GO:0030551 cyclic nucleotide binding 11/4880 37/18639 0.297297297297297 1.13551727957466 0.370434839135127 0.772588869388858 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 6/4880 19/18639 0.315789473684211 1.20614754098361 0.377447221639582 0.778877474003616 GO:0005229 intracellularly calcium-gated chloride channel activity 6/4880 19/18639 0.315789473684211 1.20614754098361 0.377447221639582 0.778877474003616 GO:0005346 purine ribonucleotide transmembrane transporter activity 6/4880 19/18639 0.315789473684211 1.20614754098361 0.377447221639582 0.778877474003616 GO:0005520 insulin-like growth factor binding 6/4880 19/18639 0.315789473684211 1.20614754098361 0.377447221639582 0.778877474003616 GO:0022821 solute:potassium antiporter activity 6/4880 19/18639 0.315789473684211 1.20614754098361 0.377447221639582 0.778877474003616 GO:0070003 threonine-type peptidase activity 6/4880 19/18639 0.315789473684211 1.20614754098361 0.377447221639582 0.778877474003616 GO:0141147 intracellularly calcium-gated channel activity 6/4880 19/18639 0.315789473684211 1.20614754098361 0.377447221639582 0.778877474003616 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 36/4880 130/18639 0.276923076923077 1.05769861286255 0.379333602449692 0.780673468584211 GO:0015175 neutral L-amino acid transmembrane transporter activity 12/4880 41/18639 0.292682926829268 1.11789284286285 0.382869791861296 0.780673468584211 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 19/4880 67/18639 0.283582089552239 1.08313249327135 0.387081473111328 0.780673468584211 GO:0004000 adenosine deaminase activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0004859 phospholipase inhibitor activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0005095 GTPase inhibitor activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0015269 calcium-activated potassium channel activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0016273 arginine N-methyltransferase activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0016274 protein-arginine N-methyltransferase activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0016801 hydrolase activity, acting on ether bonds 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0016803 ether hydrolase activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0016840 carbon-nitrogen lyase activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0035251 UDP-glucosyltransferase activity 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0042301 phosphate ion binding 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0045295 gamma-catenin binding 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0097371 MDM2/MDM4 family protein binding 4/4880 12/18639 0.333333333333333 1.27315573770492 0.388047369281595 0.780673468584211 GO:0170055 lipid transmembrane transporter activity 16/4880 56/18639 0.285714285714286 1.09127634660422 0.390734176612779 0.78492108527221 GO:0004519 endonuclease activity 35/4880 127/18639 0.275590551181102 1.05260907448044 0.394451728292663 0.789549333791393 GO:0008376 acetylgalactosaminyltransferase activity 10/4880 34/18639 0.294117647058824 1.12337270973963 0.396453911854776 0.789549333791393 GO:0003887 DNA-directed DNA polymerase activity 7/4880 23/18639 0.304347826086957 1.16244654312188 0.39651121235125 0.789549333791393 GO:0005283 amino acid:sodium symporter activity 7/4880 23/18639 0.304347826086957 1.16244654312188 0.39651121235125 0.789549333791393 GO:0016493 C-C chemokine receptor activity 7/4880 23/18639 0.304347826086957 1.16244654312188 0.39651121235125 0.789549333791393 GO:0017134 fibroblast growth factor binding 7/4880 23/18639 0.304347826086957 1.16244654312188 0.39651121235125 0.789549333791393 GO:0005501 retinoid binding 11/4880 38/18639 0.289473684210526 1.10563524590164 0.408524065198821 0.811101637454427 GO:0019840 isoprenoid binding 11/4880 38/18639 0.289473684210526 1.10563524590164 0.408524065198821 0.811101637454427 GO:0008266 poly(U) RNA binding 8/4880 27/18639 0.296296296296296 1.13169398907104 0.412101633070041 0.814529183100358 GO:0015378 sodium:chloride symporter activity 5/4880 16/18639 0.3125 1.19358350409836 0.412639050969463 0.814529183100358 GO:0016722 oxidoreductase activity, acting on metal ions 5/4880 16/18639 0.3125 1.19358350409836 0.412639050969463 0.814529183100358 GO:0055102 lipase inhibitor activity 5/4880 16/18639 0.3125 1.19358350409836 0.412639050969463 0.814529183100358 GO:0005516 calmodulin binding 56/4880 207/18639 0.270531400966184 1.03328581610834 0.413305338244725 0.814665435499718 GO:0051879 Hsp90 protein binding 12/4880 42/18639 0.285714285714286 1.09127634660422 0.419258398794438 0.825207007150957 GO:0004601 peroxidase activity 16/4880 57/18639 0.280701754385965 1.07213114754098 0.421941489177799 0.829291341842245 GO:0044325 transmembrane transporter binding 37/4880 136/18639 0.272058823529412 1.03911975650916 0.424819196552885 0.833425695256228 GO:0005452 solute:inorganic anion antiporter activity 9/4880 31/18639 0.290322580645161 1.10887757800106 0.425267070306697 0.833425695256228 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 25/4880 91/18639 0.274725274725275 1.04930417942713 0.428773224983721 0.834877710627021 GO:0017022 myosin binding 21/4880 76/18639 0.276315789473684 1.05537909836066 0.429604341709799 0.834877710627021 GO:0098631 cell adhesion mediator activity 21/4880 76/18639 0.276315789473684 1.05537909836066 0.429604341709799 0.834877710627021 GO:0016505 peptidase activator activity involved in apoptotic process 6/4880 20/18639 0.3 1.14584016393443 0.430904624839753 0.834877710627021 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 6/4880 20/18639 0.3 1.14584016393443 0.430904624839753 0.834877710627021 GO:0030742 GTP-dependent protein binding 6/4880 20/18639 0.3 1.14584016393443 0.430904624839753 0.834877710627021 GO:0042288 MHC class I protein binding 6/4880 20/18639 0.3 1.14584016393443 0.430904624839753 0.834877710627021 GO:0061608 nuclear import signal receptor activity 6/4880 20/18639 0.3 1.14584016393443 0.430904624839753 0.834877710627021 GO:0008276 protein methyltransferase activity 26/4880 95/18639 0.273684210526316 1.04532786885246 0.434578946252939 0.84080238679292 GO:0016758 hexosyltransferase activity 53/4880 197/18639 0.269035532994924 1.02757239743696 0.435429063163126 0.841253884071535 GO:0120013 lipid transfer activity 18/4880 65/18639 0.276923076923077 1.05769861286255 0.437215588253199 0.843510696431913 GO:0004806 triacylglycerol lipase activity 7/4880 24/18639 0.291666666666667 1.1140112704918 0.44539172668941 0.855653965076557 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 7/4880 24/18639 0.291666666666667 1.1140112704918 0.44539172668941 0.855653965076557 GO:0030215 semaphorin receptor binding 7/4880 24/18639 0.291666666666667 1.1140112704918 0.44539172668941 0.855653965076557 GO:0005172 vascular endothelial growth factor receptor binding 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0015651 quaternary ammonium group transmembrane transporter activity 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0031994 insulin-like growth factor I binding 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0045159 myosin II binding 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0061459 L-arginine transmembrane transporter activity 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0071714 icosanoid transmembrane transporter activity 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/4880 13/18639 0.307692307692308 1.17522068095839 0.455350780781331 0.863211211524542 GO:0008200 ion channel inhibitor activity 12/4880 43/18639 0.27906976744186 1.06589782691575 0.455654011948439 0.863211211524542 GO:0046625 sphingolipid binding 8/4880 28/18639 0.285714285714286 1.09127634660422 0.457392355111788 0.865302596910511 GO:0140142 nucleocytoplasmic carrier activity 9/4880 32/18639 0.28125 1.07422515368852 0.467643798378423 0.882403338928986 GO:0016597 amino acid binding 14/4880 51/18639 0.274509803921569 1.04848119575699 0.471180254286495 0.882403338928986 GO:0030544 Hsp70 protein binding 14/4880 51/18639 0.274509803921569 1.04848119575699 0.471180254286495 0.882403338928986 GO:0005092 GDP-dissociation inhibitor activity 5/4880 17/18639 0.294117647058824 1.12337270973963 0.471283151543504 0.882403338928986 GO:0038191 neuropilin binding 5/4880 17/18639 0.294117647058824 1.12337270973963 0.471283151543504 0.882403338928986 GO:0045125 bioactive lipid receptor activity 5/4880 17/18639 0.294117647058824 1.12337270973963 0.471283151543504 0.882403338928986 GO:0048038 quinone binding 5/4880 17/18639 0.294117647058824 1.12337270973963 0.471283151543504 0.882403338928986 GO:0008028 monocarboxylic acid transmembrane transporter activity 19/4880 70/18639 0.271428571428571 1.036712529274 0.472656563455736 0.882403338928986 GO:0015103 inorganic anion transmembrane transporter activity 44/4880 165/18639 0.266666666666667 1.01852459016393 0.473190494711215 0.882403338928986 GO:0003727 single-stranded RNA binding 24/4880 89/18639 0.269662921348315 1.02996868668263 0.473308199130443 0.882403338928986 GO:0005496 steroid binding 29/4880 108/18639 0.268518518518519 1.02559767759563 0.473547832914969 0.882403338928986 GO:0004190 aspartic-type endopeptidase activity 10/4880 36/18639 0.277777777777778 1.0609631147541 0.476603140080763 0.8856766799321 GO:0055106 ubiquitin-protein transferase regulator activity 10/4880 36/18639 0.277777777777778 1.0609631147541 0.476603140080763 0.8856766799321 GO:0019200 carbohydrate kinase activity 6/4880 21/18639 0.285714285714286 1.09127634660422 0.483522703647162 0.896819350337987 GO:0015036 disulfide oxidoreductase activity 11/4880 40/18639 0.275 1.05035348360656 0.484571745747138 0.896819350337987 GO:0015144 carbohydrate transmembrane transporter activity 11/4880 40/18639 0.275 1.05035348360656 0.484571745747138 0.896819350337987 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 7/4880 25/18639 0.28 1.06945081967213 0.493504612572481 0.899236724133481 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 7/4880 25/18639 0.28 1.06945081967213 0.493504612572481 0.899236724133481 GO:0019211 phosphatase activator activity 7/4880 25/18639 0.28 1.06945081967213 0.493504612572481 0.899236724133481 GO:0120020 cholesterol transfer activity 7/4880 25/18639 0.28 1.06945081967213 0.493504612572481 0.899236724133481 GO:0035250 UDP-galactosyltransferase activity 8/4880 29/18639 0.275862068965517 1.05364612775579 0.501971670579812 0.899236724133481 GO:0106222 lncRNA binding 8/4880 29/18639 0.275862068965517 1.05364612775579 0.501971670579812 0.899236724133481 GO:0042626 ATPase-coupled transmembrane transporter activity 26/4880 98/18639 0.26530612244898 1.01332803613249 0.50725245134327 0.899236724133481 GO:0015108 chloride transmembrane transporter activity 32/4880 121/18639 0.264462809917355 1.01010703156754 0.508358857310101 0.899236724133481 GO:0004518 nuclease activity 55/4880 209/18639 0.263157894736842 1.00512295081967 0.508951238531017 0.899236724133481 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 9/4880 33/18639 0.272727272727273 1.04167287630402 0.509354748507818 0.899236724133481 GO:0001094 TFIID-class transcription factor complex binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0005345 purine nucleobase transmembrane transporter activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0005522 profilin binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0005528 FK506 binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0008190 eukaryotic initiation factor 4E binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0008401 retinoic acid 4-hydroxylase activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0008641 ubiquitin-like modifier activating enzyme activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0015279 store-operated calcium channel activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0015643 toxic substance binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0016868 intramolecular phosphotransferase activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0019911 structural constituent of myelin sheath 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0030957 Tat protein binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0031419 cobalamin binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0035256 G protein-coupled glutamate receptor binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0043208 glycosphingolipid binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0050308 sugar-phosphatase activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0050815 phosphoserine residue binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0070097 delta-catenin binding 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0070739 protein-glutamic acid ligase activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0070740 tubulin-glutamic acid ligase activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 3/4880 10/18639 0.3 1.14584016393443 0.509611427973006 0.899236724133481 GO:0015171 amino acid transmembrane transporter activity 27/4880 102/18639 0.264705882352941 1.01103543876567 0.511373449185126 0.901180083576889 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 16/4880 60/18639 0.266666666666667 1.01852459016393 0.515160162851233 0.906681886618171 GO:0070001 aspartic-type peptidase activity 10/4880 37/18639 0.27027027027027 1.03228843597696 0.515924733023593 0.906857391551779 GO:0004065 arylsulfatase activity 4/4880 14/18639 0.285714285714286 1.09127634660422 0.51994051988569 0.908065133321487 GO:0005313 L-glutamate transmembrane transporter activity 4/4880 14/18639 0.285714285714286 1.09127634660422 0.51994051988569 0.908065133321487 GO:0016530 metallochaperone activity 4/4880 14/18639 0.285714285714286 1.09127634660422 0.51994051988569 0.908065133321487 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 4/4880 14/18639 0.285714285714286 1.09127634660422 0.51994051988569 0.908065133321487 GO:0098847 sequence-specific single stranded DNA binding 4/4880 14/18639 0.285714285714286 1.09127634660422 0.51994051988569 0.908065133321487 GO:0017080 sodium channel regulator activity 11/4880 41/18639 0.268292682926829 1.02473510595762 0.521862462171947 0.909093739977696 GO:0140828 metal cation:monoatomic cation antiporter activity 11/4880 41/18639 0.268292682926829 1.02473510595762 0.521862462171947 0.909093739977696 GO:0003777 microtubule motor activity 18/4880 68/18639 0.264705882352941 1.01103543876567 0.52468636066821 0.91145509130092 GO:0005548 phospholipid transporter activity 18/4880 68/18639 0.264705882352941 1.01103543876567 0.52468636066821 0.91145509130092 GO:0140303 intramembrane lipid transporter activity 12/4880 45/18639 0.266666666666667 1.01852459016393 0.527294406826031 0.91145509130092 GO:0008308 voltage-gated monoatomic anion channel activity 5/4880 18/18639 0.277777777777778 1.0609631147541 0.527895544081911 0.91145509130092 GO:0015373 monoatomic anion:sodium symporter activity 5/4880 18/18639 0.277777777777778 1.0609631147541 0.527895544081911 0.91145509130092 GO:1901611 phosphatidylglycerol binding 5/4880 18/18639 0.277777777777778 1.0609631147541 0.527895544081911 0.91145509130092 GO:1990381 ubiquitin-specific protease binding 5/4880 18/18639 0.277777777777778 1.0609631147541 0.527895544081911 0.91145509130092 GO:0008093 cytoskeletal anchor activity 6/4880 22/18639 0.272727272727273 1.04167287630402 0.534504416162301 0.921699144937267 GO:0061134 peptidase regulator activity 59/4880 226/18639 0.261061946902655 0.997117546786595 0.53598712698013 0.923088940910224 GO:0005544 calcium-dependent phospholipid binding 14/4880 53/18639 0.264150943396226 1.00891586761522 0.536984999259359 0.923641284980789 GO:0004529 DNA exonuclease activity 7/4880 26/18639 0.269230769230769 1.02831809583859 0.540237912134727 0.925734311748452 GO:0005112 Notch binding 7/4880 26/18639 0.269230769230769 1.02831809583859 0.540237912134727 0.925734311748452 GO:0051139 metal cation:proton antiporter activity 7/4880 26/18639 0.269230769230769 1.02831809583859 0.540237912134727 0.925734311748452 GO:0001965 G-protein alpha-subunit binding 8/4880 30/18639 0.266666666666667 1.01852459016393 0.545351301377263 0.927230702255614 GO:0008106 alcohol dehydrogenase (NADP+) activity 8/4880 30/18639 0.266666666666667 1.01852459016393 0.545351301377263 0.927230702255614 GO:0008187 poly-pyrimidine tract binding 8/4880 30/18639 0.266666666666667 1.01852459016393 0.545351301377263 0.927230702255614 GO:0015215 nucleotide transmembrane transporter activity 8/4880 30/18639 0.266666666666667 1.01852459016393 0.545351301377263 0.927230702255614 GO:0031210 phosphatidylcholine binding 8/4880 30/18639 0.266666666666667 1.01852459016393 0.545351301377263 0.927230702255614 GO:0033612 receptor serine/threonine kinase binding 8/4880 30/18639 0.266666666666667 1.01852459016393 0.545351301377263 0.927230702255614 GO:0005539 glycosaminoglycan binding 63/4880 242/18639 0.260330578512397 0.994324109199296 0.545869687618225 0.927230702255614 GO:0000146 microfilament motor activity 10/4880 38/18639 0.263157894736842 1.00512295081967 0.554282114389583 0.938015885890063 GO:0005109 frizzled binding 10/4880 38/18639 0.263157894736842 1.00512295081967 0.554282114389583 0.938015885890063 GO:0043531 ADP binding 10/4880 38/18639 0.263157894736842 1.00512295081967 0.554282114389583 0.938015885890063 GO:0004521 RNA endonuclease activity 19/4880 73/18639 0.26027397260274 0.994107904783292 0.556671852549701 0.940892697494165 GO:0004386 helicase activity 40/4880 155/18639 0.258064516129032 0.985668958223162 0.57318177872701 0.95583053948751 GO:0000774 adenyl-nucleotide exchange factor activity 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0004467 long-chain fatty acid-CoA ligase activity 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0004865 protein serine/threonine phosphatase inhibitor activity 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0005523 tropomyosin binding 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0008242 omega peptidase activity 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0030553 cGMP binding 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0031005 filamin binding 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0048531 beta-1,3-galactosyltransferase activity 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0050780 dopamine receptor binding 4/4880 15/18639 0.266666666666667 1.01852459016393 0.58062445165502 0.95583053948751 GO:0000099 sulfur amino acid transmembrane transporter activity 3/4880 11/18639 0.272727272727273 1.04167287630402 0.580839143836483 0.95583053948751 GO:0001851 complement component C3b binding 3/4880 11/18639 0.272727272727273 1.04167287630402 0.580839143836483 0.95583053948751 GO:0005225 volume-sensitive anion channel activity 3/4880 11/18639 0.272727272727273 1.04167287630402 0.580839143836483 0.95583053948751 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 3/4880 11/18639 0.272727272727273 1.04167287630402 0.580839143836483 0.95583053948751 GO:0015205 nucleobase transmembrane transporter activity 3/4880 11/18639 0.272727272727273 1.04167287630402 0.580839143836483 0.95583053948751 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/4880 11/18639 0.272727272727273 1.04167287630402 0.580839143836483 0.95583053948751 GO:0019206 nucleoside kinase activity 3/4880 11/18639 0.272727272727273 1.04167287630402 0.580839143836483 0.95583053948751 GO:0032404 mismatch repair complex binding 3/4880 11/18639 0.272727272727273 1.04167287630402 0.580839143836483 0.95583053948751 GO:0008301 DNA binding, bending 5/4880 19/18639 0.263157894736842 1.00512295081967 0.581627087811315 0.95583053948751 GO:0008574 plus-end-directed microtubule motor activity 5/4880 19/18639 0.263157894736842 1.00512295081967 0.581627087811315 0.95583053948751 GO:0016918 retinal binding 5/4880 19/18639 0.263157894736842 1.00512295081967 0.581627087811315 0.95583053948751 GO:0042577 lipid phosphatase activity 5/4880 19/18639 0.263157894736842 1.00512295081967 0.581627087811315 0.95583053948751 GO:0046527 glucosyltransferase activity 5/4880 19/18639 0.263157894736842 1.00512295081967 0.581627087811315 0.95583053948751 GO:0000295 adenine nucleotide transmembrane transporter activity 6/4880 23/18639 0.260869565217391 0.996382751247327 0.583207899860319 0.956124489674851 GO:0140103 catalytic activity, acting on a glycoprotein 6/4880 23/18639 0.260869565217391 0.996382751247327 0.583207899860319 0.956124489674851 GO:0001671 ATPase activator activity 7/4880 27/18639 0.259259259259259 0.990232240437158 0.585085609807368 0.958051346671368 GO:0047499 calcium-independent phospholipase A2 activity 8/4880 31/18639 0.258064516129032 0.985668958223162 0.58711972957572 0.960229389857653 GO:0004623 phospholipase A2 activity 9/4880 35/18639 0.257142857142857 0.982148711943794 0.589233954110035 0.960233110401538 GO:0005343 organic acid:sodium symporter activity 9/4880 35/18639 0.257142857142857 0.982148711943794 0.589233954110035 0.960233110401538 GO:0034061 DNA polymerase activity 9/4880 35/18639 0.257142857142857 0.982148711943794 0.589233954110035 0.960233110401538 GO:0061749 forked DNA-dependent helicase activity 12/4880 47/18639 0.25531914893617 0.975183118242065 0.595698845437966 0.968454380425966 GO:1990518 single-stranded 3'-5' DNA helicase activity 12/4880 47/18639 0.25531914893617 0.975183118242065 0.595698845437966 0.968454380425966 GO:0016830 carbon-carbon lyase activity 13/4880 51/18639 0.254901960784314 0.973589681774349 0.597836697648971 0.970763868595688 GO:0008170 N-methyltransferase activity 25/4880 98/18639 0.255102040816327 0.974353880896621 0.598542825138544 0.970763868595688 GO:0008201 heparin binding 44/4880 172/18639 0.255813953488372 0.9770730080061 0.600331989040819 0.972509302911731 GO:1901682 sulfur compound transmembrane transporter activity 16/4880 63/18639 0.253968253968254 0.970023419203747 0.604101334846603 0.977454591614195 GO:0061775 cohesin loader activity 39/4880 153/18639 0.254901960784314 0.973589681774349 0.608036468891842 0.982656094275442 GO:0004866 endopeptidase inhibitor activity 41/4880 161/18639 0.254658385093168 0.972659352408105 0.611978521949146 0.987856454365248 GO:0004033 aldo-keto reductase (NADPH) activity 9/4880 36/18639 0.25 0.954866803278689 0.626777558786459 0.998774785119848 GO:0004869 cysteine-type endopeptidase inhibitor activity 9/4880 36/18639 0.25 0.954866803278689 0.626777558786459 0.998774785119848 GO:0008378 galactosyltransferase activity 8/4880 32/18639 0.25 0.954866803278689 0.62694503997482 0.998774785119848 GO:0031369 translation initiation factor binding 8/4880 32/18639 0.25 0.954866803278689 0.62694503997482 0.998774785119848 GO:0070717 poly-purine tract binding 8/4880 32/18639 0.25 0.954866803278689 0.62694503997482 0.998774785119848 GO:0045499 chemorepellent activity 7/4880 28/18639 0.25 0.954866803278689 0.627650028039228 0.998774785119848 GO:0051119 sugar transmembrane transporter activity 7/4880 28/18639 0.25 0.954866803278689 0.627650028039228 0.998774785119848 GO:0051393 alpha-actinin binding 7/4880 28/18639 0.25 0.954866803278689 0.627650028039228 0.998774785119848 GO:0009378 four-way junction helicase activity 12/4880 48/18639 0.25 0.954866803278689 0.628161260762375 0.998774785119848 GO:0036121 double-stranded DNA helicase activity 12/4880 48/18639 0.25 0.954866803278689 0.628161260762375 0.998774785119848 GO:0043138 3'-5' DNA helicase activity 12/4880 48/18639 0.25 0.954866803278689 0.628161260762375 0.998774785119848 GO:0030170 pyridoxal phosphate binding 14/4880 56/18639 0.25 0.954866803278689 0.629956774801131 0.998774785119848 GO:0000339 RNA cap binding 5/4880 20/18639 0.25 0.954866803278689 0.631867908801835 0.998774785119848 GO:0005326 neurotransmitter transmembrane transporter activity 5/4880 20/18639 0.25 0.954866803278689 0.631867908801835 0.998774785119848 GO:0031418 L-ascorbic acid binding 5/4880 20/18639 0.25 0.954866803278689 0.631867908801835 0.998774785119848 GO:0042379 chemokine receptor binding 18/4880 72/18639 0.25 0.954866803278689 0.634487374516706 0.998774785119848 GO:0005319 lipid transporter activity 45/4880 178/18639 0.252808988764045 0.965595643764966 0.636262461689038 0.998774785119848 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 4/4880 16/18639 0.25 0.954866803278689 0.636619585216873 0.998774785119848 GO:0008296 3'-5'-DNA exonuclease activity 4/4880 16/18639 0.25 0.954866803278689 0.636619585216873 0.998774785119848 GO:0015385 sodium:proton antiporter activity 4/4880 16/18639 0.25 0.954866803278689 0.636619585216873 0.998774785119848 GO:0015562 efflux transmembrane transporter activity 4/4880 16/18639 0.25 0.954866803278689 0.636619585216873 0.998774785119848 GO:0140327 flippase activity 4/4880 16/18639 0.25 0.954866803278689 0.636619585216873 0.998774785119848 GO:0051117 ATPase binding 21/4880 84/18639 0.25 0.954866803278689 0.638269310482777 0.998774785119848 GO:0003995 acyl-CoA dehydrogenase activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0005049 nuclear export signal receptor activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0005436 sodium:phosphate symporter activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0005527 macrolide binding 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0008504 monoamine transmembrane transporter activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0015132 prostaglandin transmembrane transporter activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0015166 polyol transmembrane transporter activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0015368 calcium:monoatomic cation antiporter activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0043047 single-stranded telomeric DNA binding 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0140829 bicarbonate:monoatomic anion antiporter activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0140900 chloride:bicarbonate antiporter activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/4880 12/18639 0.25 0.954866803278689 0.645103068688113 0.998774785119848 GO:0008514 organic anion transmembrane transporter activity 68/4880 269/18639 0.252788104089219 0.965515875434213 0.655425914278779 1 GO:0070279 vitamin B6 binding 14/4880 57/18639 0.245614035087719 0.938114754098361 0.6588006034884 1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 15/4880 61/18639 0.245901639344262 0.939213249126579 0.658884162598927 1 GO:0008146 sulfotransferase activity 13/4880 53/18639 0.245283018867925 0.936850448499845 0.658906364263605 1 GO:0001530 lipopolysaccharide binding 10/4880 41/18639 0.24390243902439 0.931577369052379 0.660900245027113 1 GO:0005416 amino acid:monoatomic cation symporter activity 7/4880 29/18639 0.241379310344828 0.92194036178632 0.667638596321768 1 GO:0099604 ligand-gated calcium channel activity 7/4880 29/18639 0.241379310344828 0.92194036178632 0.667638596321768 1 GO:0004540 RNA nuclease activity 30/4880 121/18639 0.247933884297521 0.946975342094567 0.669632381916618 1 GO:0061135 endopeptidase regulator activity 46/4880 184/18639 0.25 0.954866803278689 0.67002387300808 1 GO:0022804 active transmembrane transporter activity 116/4880 457/18639 0.25382932166302 0.969492771819062 0.670218754251551 1 GO:0001848 complement binding 6/4880 25/18639 0.24 0.916672131147541 0.67198094372793 1 GO:0047617 fatty acyl-CoA hydrolase activity 6/4880 25/18639 0.24 0.916672131147541 0.67198094372793 1 GO:0008509 monoatomic anion transmembrane transporter activity 37/4880 149/18639 0.248322147651007 0.948458301243261 0.676535846499601 1 GO:0001846 opsonin binding 5/4880 21/18639 0.238095238095238 0.909396955503513 0.67822578541267 1 GO:0036122 BMP binding 5/4880 21/18639 0.238095238095238 0.909396955503513 0.67822578541267 1 GO:0061891 calcium ion sensor activity 5/4880 21/18639 0.238095238095238 0.909396955503513 0.67822578541267 1 GO:0072542 protein phosphatase activator activity 5/4880 21/18639 0.238095238095238 0.909396955503513 0.67822578541267 1 GO:0030414 peptidase inhibitor activity 42/4880 169/18639 0.248520710059172 0.949216703851004 0.681561004111187 1 GO:1901681 sulfur compound binding 69/4880 275/18639 0.250909090909091 0.958339046199702 0.682710649109302 1 GO:0003684 damaged DNA binding 18/4880 74/18639 0.243243243243243 0.929059592379264 0.684458436449761 1 GO:0004549 tRNA-specific ribonuclease activity 4/4880 17/18639 0.235294117647059 0.898698167791707 0.687492334039448 1 GO:0009881 photoreceptor activity 4/4880 17/18639 0.235294117647059 0.898698167791707 0.687492334039448 1 GO:0016018 cyclosporin A binding 4/4880 17/18639 0.235294117647059 0.898698167791707 0.687492334039448 1 GO:0045236 CXCR chemokine receptor binding 4/4880 17/18639 0.235294117647059 0.898698167791707 0.687492334039448 1 GO:0051787 misfolded protein binding 4/4880 17/18639 0.235294117647059 0.898698167791707 0.687492334039448 1 GO:0004180 carboxypeptidase activity 11/4880 46/18639 0.239130434782609 0.91335085531005 0.690643782034719 1 GO:0140658 ATP-dependent chromatin remodeler activity 39/4880 158/18639 0.246835443037975 0.942779881718199 0.695118106321323 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 8/4880 34/18639 0.235294117647059 0.898698167791707 0.699827743564674 1 GO:0051427 hormone receptor binding 8/4880 34/18639 0.235294117647059 0.898698167791707 0.699827743564674 1 GO:0090482 vitamin transmembrane transporter activity 8/4880 34/18639 0.235294117647059 0.898698167791707 0.699827743564674 1 GO:0004465 lipoprotein lipase activity 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0005542 folic acid binding 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0008253 5'-nucleotidase activity 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0008417 fucosyltransferase activity 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0019855 calcium channel inhibitor activity 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0043560 insulin receptor substrate binding 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0071837 HMG box domain binding 3/4880 13/18639 0.230769230769231 0.881415510718789 0.702028755060147 1 GO:0000510 H3-H4 histone complex chaperone activity 37/4880 151/18639 0.245033112582781 0.93589593963739 0.710131198357466 1 GO:0140584 chromatin extrusion motor activity 37/4880 151/18639 0.245033112582781 0.93589593963739 0.710131198357466 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 37/4880 151/18639 0.245033112582781 0.93589593963739 0.710131198357466 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 37/4880 151/18639 0.245033112582781 0.93589593963739 0.710131198357466 1 GO:0005227 calcium-activated cation channel activity 6/4880 26/18639 0.230769230769231 0.881415510718789 0.711503853205892 1 GO:0015145 monosaccharide transmembrane transporter activity 6/4880 26/18639 0.230769230769231 0.881415510718789 0.711503853205892 1 GO:0015216 purine nucleotide transmembrane transporter activity 6/4880 26/18639 0.230769230769231 0.881415510718789 0.711503853205892 1 GO:0016289 acyl-CoA hydrolase activity 6/4880 26/18639 0.230769230769231 0.881415510718789 0.711503853205892 1 GO:0070006 metalloaminopeptidase activity 6/4880 26/18639 0.230769230769231 0.881415510718789 0.711503853205892 1 GO:0120014 phospholipid transfer activity 6/4880 26/18639 0.230769230769231 0.881415510718789 0.711503853205892 1 GO:0001664 G protein-coupled receptor binding 74/4880 297/18639 0.249158249158249 0.951651763537009 0.712146259822451 1 GO:0005243 gap junction channel activity 5/4880 22/18639 0.227272727272727 0.868060730253353 0.720496776368662 1 GO:0016881 acid-amino acid ligase activity 5/4880 22/18639 0.227272727272727 0.868060730253353 0.720496776368662 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/4880 22/18639 0.227272727272727 0.868060730253353 0.720496776368662 1 GO:0061133 endopeptidase activator activity 5/4880 22/18639 0.227272727272727 0.868060730253353 0.720496776368662 1 GO:0140784 metal ion sensor activity 5/4880 22/18639 0.227272727272727 0.868060730253353 0.720496776368662 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 10/4880 43/18639 0.232558139534884 0.888248189096454 0.723101589008332 1 GO:0015616 DNA translocase activity 37/4880 152/18639 0.243421052631579 0.929738729508197 0.726171203721613 1 GO:0140674 ATP-dependent histone chaperone activity 37/4880 152/18639 0.243421052631579 0.929738729508197 0.726171203721613 1 GO:0005201 extracellular matrix structural constituent 41/4880 168/18639 0.244047619047619 0.932131879391101 0.727610104849476 1 GO:0046943 carboxylic acid transmembrane transporter activity 46/4880 188/18639 0.24468085106383 0.934550488315312 0.729841457489438 1 GO:0016229 steroid dehydrogenase activity 8/4880 35/18639 0.228571428571429 0.873021077283372 0.732596273773457 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 4/4880 18/18639 0.222222222222222 0.848770491803279 0.733091416884459 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 14/4880 60/18639 0.233333333333333 0.891209016393443 0.737461677052904 1 GO:0005342 organic acid transmembrane transporter activity 46/4880 189/18639 0.243386243386243 0.929605776736924 0.743761600258487 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 6/4880 27/18639 0.222222222222222 0.848770491803279 0.747623351319755 1 GO:0005347 ATP transmembrane transporter activity 3/4880 14/18639 0.214285714285714 0.818457259953162 0.751689182834999 1 GO:0008494 translation activator activity 3/4880 14/18639 0.214285714285714 0.818457259953162 0.751689182834999 1 GO:0019992 diacylglycerol binding 3/4880 14/18639 0.214285714285714 0.818457259953162 0.751689182834999 1 GO:0043176 amine binding 3/4880 14/18639 0.214285714285714 0.818457259953162 0.751689182834999 1 GO:0044548 S100 protein binding 3/4880 14/18639 0.214285714285714 0.818457259953162 0.751689182834999 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/4880 14/18639 0.214285714285714 0.818457259953162 0.751689182834999 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/4880 14/18639 0.214285714285714 0.818457259953162 0.751689182834999 1 GO:0140097 catalytic activity, acting on DNA 83/4880 336/18639 0.24702380952381 0.943499341334895 0.751703329097101 1 GO:0004532 RNA exonuclease activity 9/4880 40/18639 0.225 0.85938012295082 0.756473883085893 1 GO:0050997 quaternary ammonium group binding 9/4880 40/18639 0.225 0.85938012295082 0.756473883085893 1 GO:0019842 vitamin binding 36/4880 150/18639 0.24 0.916672131147541 0.756755377658713 1 GO:0005212 structural constituent of eye lens 5/4880 23/18639 0.217391304347826 0.830318959372773 0.758632575398756 1 GO:0008171 O-methyltransferase activity 5/4880 23/18639 0.217391304347826 0.830318959372773 0.758632575398756 1 GO:0031681 G-protein beta-subunit binding 5/4880 23/18639 0.217391304347826 0.830318959372773 0.758632575398756 1 GO:0015932 nucleobase-containing compound transmembrane transporter activity 13/4880 57/18639 0.228070175438596 0.871106557377049 0.76410371812711 1 GO:0005246 calcium channel regulator activity 12/4880 53/18639 0.226415094339623 0.864785029384473 0.767852341398564 1 GO:0015106 bicarbonate transmembrane transporter activity 7/4880 32/18639 0.21875 0.835508452868852 0.770626718009804 1 GO:0022884 macromolecule transmembrane transporter activity 7/4880 32/18639 0.21875 0.835508452868852 0.770626718009804 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/4880 32/18639 0.21875 0.835508452868852 0.770626718009804 1 GO:0047498 calcium-dependent phospholipase A2 activity 7/4880 32/18639 0.21875 0.835508452868852 0.770626718009804 1 GO:0042834 peptidoglycan binding 4/4880 19/18639 0.210526315789474 0.804098360655738 0.773481904637297 1 GO:0016782 transferase activity, transferring sulphur-containing groups 16/4880 70/18639 0.228571428571429 0.873021077283372 0.776652559984361 1 GO:0000182 rDNA binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0015187 glycine transmembrane transporter activity 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0016783 sulfurtransferase activity 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0031996 thioesterase binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0032052 bile acid binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0033204 ribonuclease P RNA binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0035374 chondroitin sulfate binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0043121 neurotrophin binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0043295 glutathione binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0051880 G-quadruplex DNA binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0098505 G-rich strand telomeric DNA binding 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0140940 histone H2A methyltransferase activity 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0141109 transporter activator activity 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:1990259 histone H2AQ104 methyltransferase activity 2/4880 10/18639 0.2 0.763893442622951 0.781628877505747 1 GO:0042287 MHC protein binding 9/4880 41/18639 0.219512195121951 0.838419632147141 0.783353968789926 1 GO:0140318 protein transporter activity 9/4880 41/18639 0.219512195121951 0.838419632147141 0.783353968789926 1 GO:0003689 DNA clamp loader activity 38/4880 160/18639 0.2375 0.907123463114754 0.784543592111212 1 GO:0017116 single-stranded DNA helicase activity 13/4880 58/18639 0.224137931034483 0.856087478801583 0.786556771649048 1 GO:0016779 nucleotidyltransferase activity 32/4880 136/18639 0.235294117647059 0.898698167791707 0.787706094484077 1 GO:0005254 chloride channel activity 19/4880 83/18639 0.228915662650602 0.874335868062414 0.788550471646216 1 GO:0015370 solute:sodium symporter activity 18/4880 79/18639 0.227848101265823 0.870258352355261 0.790886445928256 1 GO:0005540 hyaluronic acid binding 5/4880 24/18639 0.208333333333333 0.795722336065574 0.792707825700897 1 GO:0015149 hexose transmembrane transporter activity 5/4880 24/18639 0.208333333333333 0.795722336065574 0.792707825700897 1 GO:0055056 D-glucose transmembrane transporter activity 5/4880 24/18639 0.208333333333333 0.795722336065574 0.792707825700897 1 GO:0008252 nucleotidase activity 3/4880 15/18639 0.2 0.763893442622951 0.794455365629993 1 GO:0016846 carbon-sulfur lyase activity 3/4880 15/18639 0.2 0.763893442622951 0.794455365629993 1 GO:0034483 heparan sulfate sulfotransferase activity 3/4880 15/18639 0.2 0.763893442622951 0.794455365629993 1 GO:0140776 protein-containing complex destabilizing activity 3/4880 15/18639 0.2 0.763893442622951 0.794455365629993 1 GO:0048020 CCR chemokine receptor binding 11/4880 50/18639 0.22 0.840282786885246 0.795733243242876 1 GO:0005125 cytokine activity 56/4880 234/18639 0.239316239316239 0.9140605296343 0.805032696411683 1 GO:0004527 exonuclease activity 19/4880 84/18639 0.226190476190476 0.863927107728337 0.806186866974316 1 GO:0015459 potassium channel regulator activity 13/4880 59/18639 0.220338983050847 0.841577521533759 0.807451687923961 1 GO:0070888 E-box binding 13/4880 59/18639 0.220338983050847 0.841577521533759 0.807451687923961 1 GO:0010851 cyclase regulator activity 4/4880 20/18639 0.2 0.763893442622951 0.808885403596163 1 GO:0043024 ribosomal small subunit binding 4/4880 20/18639 0.2 0.763893442622951 0.808885403596163 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 8/4880 38/18639 0.210526315789474 0.804098360655738 0.81575057189415 1 GO:0004016 adenylate cyclase activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0008172 S-methyltransferase activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0008271 secondary active sulfate transmembrane transporter activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0008503 benzodiazepine receptor activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0008526 phosphatidylinositol transfer activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0010854 adenylate cyclase regulator activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0015173 aromatic amino acid transmembrane transporter activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0048407 platelet-derived growth factor binding 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0050998 nitric-oxide synthase binding 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0070697 activin receptor binding 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0070990 snRNP binding 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:1900750 oligopeptide binding 2/4880 11/18639 0.181818181818182 0.694448584202683 0.826248818321139 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 13/4880 60/18639 0.216666666666667 0.827551229508197 0.826810627101062 1 GO:0008142 oxysterol binding 3/4880 16/18639 0.1875 0.716150102459016 0.830879007263791 1 GO:0019841 retinol binding 3/4880 16/18639 0.1875 0.716150102459016 0.830879007263791 1 GO:0022841 potassium ion leak channel activity 3/4880 16/18639 0.1875 0.716150102459016 0.830879007263791 1 GO:0140328 floppase activity 3/4880 16/18639 0.1875 0.716150102459016 0.830879007263791 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 6/4880 30/18639 0.2 0.763893442622951 0.835966618197353 1 GO:0022839 monoatomic ion-gated channel activity 6/4880 30/18639 0.2 0.763893442622951 0.835966618197353 1 GO:0070566 adenylyltransferase activity 6/4880 30/18639 0.2 0.763893442622951 0.835966618197353 1 GO:0000217 DNA secondary structure binding 8/4880 39/18639 0.205128205128205 0.783480453972257 0.838566282759012 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 42/4880 181/18639 0.232044198895028 0.886285209673037 0.841533240306396 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 30/4880 132/18639 0.227272727272727 0.868060730253353 0.842754183362614 1 GO:0004867 serine-type endopeptidase inhibitor activity 21/4880 95/18639 0.221052631578947 0.844303278688525 0.847195763882457 1 GO:0000175 3'-5'-RNA exonuclease activity 7/4880 35/18639 0.2 0.763893442622951 0.848022463191422 1 GO:0043015 gamma-tubulin binding 7/4880 35/18639 0.2 0.763893442622951 0.848022463191422 1 GO:0048029 monosaccharide binding 16/4880 74/18639 0.216216216216216 0.825830748781568 0.848114687568341 1 GO:0008143 poly(A) binding 5/4880 26/18639 0.192307692307692 0.734512925598991 0.849409949286578 1 GO:0141108 transporter regulator activity 39/4880 170/18639 0.229411764705882 0.876230713596914 0.854286145055467 1 GO:0016860 intramolecular oxidoreductase activity 11/4880 53/18639 0.207547169811321 0.7927196102691 0.855551247852653 1 GO:0003697 single-stranded DNA binding 27/4880 121/18639 0.223140495867769 0.852277807885111 0.859433393400786 1 GO:0051082 unfolded protein binding 27/4880 121/18639 0.223140495867769 0.852277807885111 0.859433393400786 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/4880 17/18639 0.176470588235294 0.67402362584378 0.861604722954721 1 GO:0004659 prenyltransferase activity 3/4880 17/18639 0.176470588235294 0.67402362584378 0.861604722954721 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 3/4880 17/18639 0.176470588235294 0.67402362584378 0.861604722954721 1 GO:0032183 SUMO binding 3/4880 17/18639 0.176470588235294 0.67402362584378 0.861604722954721 1 GO:0000340 RNA 7-methylguanosine cap binding 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0003720 telomerase activity 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0004526 ribonuclease P activity 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0010853 cyclase activator activity 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0016208 AMP binding 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0017166 vinculin binding 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0031543 peptidyl-proline dioxygenase activity 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0034452 dynactin binding 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0036009 protein-glutamine N-methyltransferase activity 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/4880 12/18639 0.166666666666667 0.636577868852459 0.862477968247745 1 GO:0004175 endopeptidase activity 97/4880 405/18639 0.239506172839506 0.914785974499089 0.862485268410326 1 GO:0008970 phospholipase A1 activity 4/4880 22/18639 0.181818181818182 0.694448584202683 0.866102635790991 1 GO:0070034 telomerase RNA binding 4/4880 22/18639 0.181818181818182 0.694448584202683 0.866102635790991 1 GO:0008408 3'-5' exonuclease activity 12/4880 58/18639 0.206896551724138 0.790234595816846 0.866311997471595 1 GO:0045505 dynein intermediate chain binding 7/4880 36/18639 0.194444444444444 0.742674180327869 0.868586114775965 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 27/4880 122/18639 0.221311475409836 0.845291924213921 0.870648213658015 1 GO:0005104 fibroblast growth factor receptor binding 5/4880 27/18639 0.185185185185185 0.707308743169399 0.872543267006311 1 GO:0008320 protein transmembrane transporter activity 5/4880 27/18639 0.185185185185185 0.707308743169399 0.872543267006311 1 GO:0016405 CoA-ligase activity 5/4880 27/18639 0.185185185185185 0.707308743169399 0.872543267006311 1 GO:0140713 histone chaperone activity 37/4880 164/18639 0.225609756097561 0.861709066373451 0.875696769589623 1 GO:0016877 ligase activity, forming carbon-sulfur bonds 8/4880 41/18639 0.195121951219512 0.745261895241903 0.877449483013623 1 GO:0022829 wide pore channel activity 7/4880 37/18639 0.189189189189189 0.722601905183872 0.886798592521863 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/4880 18/18639 0.166666666666667 0.636577868852459 0.887307384168774 1 GO:0008525 phosphatidylcholine transporter activity 3/4880 18/18639 0.166666666666667 0.636577868852459 0.887307384168774 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/4880 18/18639 0.166666666666667 0.636577868852459 0.887307384168774 1 GO:0031690 adrenergic receptor binding 3/4880 18/18639 0.166666666666667 0.636577868852459 0.887307384168774 1 GO:0099602 neurotransmitter receptor regulator activity 3/4880 18/18639 0.166666666666667 0.636577868852459 0.887307384168774 1 GO:0016849 phosphorus-oxygen lyase activity 4/4880 23/18639 0.173913043478261 0.664255167498218 0.88872791166304 1 GO:0003964 RNA-directed DNA polymerase activity 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0030955 potassium ion binding 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0031432 titin binding 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0039706 co-receptor binding 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0046975 histone H3K36 methyltransferase activity 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0070700 BMP receptor binding 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0097157 pre-mRNA intronic binding 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0140333 glycerophospholipid flippase activity 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0140666 annealing activity 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:1901338 catecholamine binding 2/4880 13/18639 0.153846153846154 0.587610340479193 0.891650552463672 1 GO:0005253 monoatomic anion channel activity 22/4880 103/18639 0.213592233009709 0.815808530956549 0.892403682686869 1 GO:0051537 2 iron, 2 sulfur cluster binding 5/4880 28/18639 0.178571428571429 0.682047716627635 0.892586727534187 1 GO:0005010 insulin-like growth factor receptor activity 10/4880 51/18639 0.196078431372549 0.748915139826422 0.89345920164206 1 GO:0005021 vascular endothelial growth factor receptor activity 10/4880 51/18639 0.196078431372549 0.748915139826422 0.89345920164206 1 GO:0031492 nucleosomal DNA binding 8/4880 42/18639 0.19047619047619 0.72751756440281 0.893789697056049 1 GO:0043022 ribosome binding 24/4880 112/18639 0.214285714285714 0.818457259953162 0.89740497127321 1 GO:0140359 ABC-type transporter activity 9/4880 47/18639 0.191489361702128 0.731387338681549 0.900480812776283 1 GO:0003678 DNA helicase activity 15/4880 74/18639 0.202702702702703 0.77421632698272 0.904641807312057 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 10/4880 52/18639 0.192307692307692 0.734512925598991 0.906818633456226 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/4880 24/18639 0.166666666666667 0.636577868852459 0.907931928855469 1 GO:0016247 channel regulator activity 37/4880 168/18639 0.220238095238095 0.841192183840749 0.908434514738348 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/4880 19/18639 0.157894736842105 0.603073770491803 0.908649661580925 1 GO:0008381 mechanosensitive monoatomic ion channel activity 3/4880 19/18639 0.157894736842105 0.603073770491803 0.908649661580925 1 GO:0022840 leak channel activity 3/4880 19/18639 0.157894736842105 0.603073770491803 0.908649661580925 1 GO:0022842 narrow pore channel activity 3/4880 19/18639 0.157894736842105 0.603073770491803 0.908649661580925 1 GO:0031420 alkali metal ion binding 3/4880 19/18639 0.157894736842105 0.603073770491803 0.908649661580925 1 GO:0046624 sphingolipid transporter activity 3/4880 19/18639 0.157894736842105 0.603073770491803 0.908649661580925 1 GO:0046982 protein heterodimerization activity 86/4880 369/18639 0.233062330623306 0.890173930427829 0.909301416262422 1 GO:0003785 actin monomer binding 5/4880 29/18639 0.172413793103448 0.658528829847371 0.909845506541909 1 GO:0004181 metallocarboxypeptidase activity 5/4880 29/18639 0.172413793103448 0.658528829847371 0.909845506541909 1 GO:0099106 ion channel regulator activity 35/4880 160/18639 0.21875 0.835508452868852 0.911071132015006 1 GO:0043021 ribonucleoprotein complex binding 39/4880 177/18639 0.220338983050847 0.841577521533759 0.913004452295598 1 GO:0015035 protein-disulfide reductase activity 6/4880 34/18639 0.176470588235294 0.67402362584378 0.913058040002997 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6/4880 34/18639 0.176470588235294 0.67402362584378 0.913058040002997 1 GO:0008235 metalloexopeptidase activity 13/4880 66/18639 0.196969696969697 0.752319299552906 0.913471302033127 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 9/4880 48/18639 0.1875 0.716150102459016 0.913591681654612 1 GO:0005262 calcium channel activity 28/4880 131/18639 0.213740458015267 0.816374671505444 0.914807068138437 1 GO:0005344 oxygen carrier activity 2/4880 14/18639 0.142857142857143 0.545638173302108 0.914977447401783 1 GO:0008174 mRNA methyltransferase activity 2/4880 14/18639 0.142857142857143 0.545638173302108 0.914977447401783 1 GO:0008195 phosphatidate phosphatase activity 2/4880 14/18639 0.142857142857143 0.545638173302108 0.914977447401783 1 GO:0008559 ABC-type xenobiotic transporter activity 2/4880 14/18639 0.142857142857143 0.545638173302108 0.914977447401783 1 GO:0015926 glucosidase activity 2/4880 14/18639 0.142857142857143 0.545638173302108 0.914977447401783 1 GO:0031404 chloride ion binding 2/4880 14/18639 0.142857142857143 0.545638173302108 0.914977447401783 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 7/4880 39/18639 0.179487179487179 0.685545397225725 0.916901940152815 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 10/4880 53/18639 0.188679245283019 0.720654191153727 0.918741281271011 1 GO:0038064 collagen receptor activity 10/4880 53/18639 0.188679245283019 0.720654191153727 0.918741281271011 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/4880 44/18639 0.181818181818182 0.694448584202683 0.921017645865194 1 GO:0140104 molecular carrier activity 56/4880 249/18639 0.224899598393574 0.858996642306933 0.922021794269944 1 GO:0005537 D-mannose binding 4/4880 25/18639 0.16 0.611114754098361 0.924130477933817 1 GO:0015645 fatty acid ligase activity 4/4880 25/18639 0.16 0.611114754098361 0.924130477933817 1 GO:0015662 P-type ion transporter activity 4/4880 25/18639 0.16 0.611114754098361 0.924130477933817 1 GO:0120515 fatty acid-CoA ligase activity 4/4880 25/18639 0.16 0.611114754098361 0.924130477933817 1 GO:0140358 P-type transmembrane transporter activity 4/4880 25/18639 0.16 0.611114754098361 0.924130477933817 1 GO:0048019 receptor antagonist activity 5/4880 30/18639 0.166666666666667 0.636577868852459 0.924621284210821 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 3/4880 20/18639 0.15 0.572920081967213 0.926255118872354 1 GO:0015464 acetylcholine receptor activity 3/4880 20/18639 0.15 0.572920081967213 0.926255118872354 1 GO:0016408 C-acyltransferase activity 3/4880 20/18639 0.15 0.572920081967213 0.926255118872354 1 GO:0140939 histone H4 methyltransferase activity 3/4880 20/18639 0.15 0.572920081967213 0.926255118872354 1 GO:0042562 hormone binding 19/4880 94/18639 0.202127659574468 0.772019968608301 0.927970692051315 1 GO:0140597 protein carrier chaperone 41/4880 188/18639 0.218085106382979 0.83296891349843 0.929302287849207 1 GO:0003724 RNA helicase activity 15/4880 77/18639 0.194805194805195 0.744052054502874 0.93309065484511 1 GO:0008020 G protein-coupled photoreceptor activity 2/4880 15/18639 0.133333333333333 0.509262295081967 0.933519306135905 1 GO:0015116 sulfate transmembrane transporter activity 2/4880 15/18639 0.133333333333333 0.509262295081967 0.933519306135905 1 GO:0015250 water channel activity 2/4880 15/18639 0.133333333333333 0.509262295081967 0.933519306135905 1 GO:0031386 protein tag activity 2/4880 15/18639 0.133333333333333 0.509262295081967 0.933519306135905 1 GO:0033130 acetylcholine receptor binding 2/4880 15/18639 0.133333333333333 0.509262295081967 0.933519306135905 1 GO:0140161 monocarboxylate:sodium symporter activity 2/4880 15/18639 0.133333333333333 0.509262295081967 0.933519306135905 1 GO:0141047 molecular tag activity 2/4880 15/18639 0.133333333333333 0.509262295081967 0.933519306135905 1 GO:0005017 platelet-derived growth factor receptor activity 9/4880 50/18639 0.18 0.687504098360656 0.935442991175122 1 GO:0005019 platelet-derived growth factor beta-receptor activity 9/4880 50/18639 0.18 0.687504098360656 0.935442991175122 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/4880 31/18639 0.161290322580645 0.616043098889476 0.937203938416901 1 GO:0016878 acid-thiol ligase activity 5/4880 31/18639 0.161290322580645 0.616043098889476 0.937203938416901 1 GO:0030507 spectrin binding 4/4880 26/18639 0.153846153846154 0.587610340479193 0.937716028596952 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 6/4880 36/18639 0.166666666666667 0.636577868852459 0.938099188946449 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 6/4880 36/18639 0.166666666666667 0.636577868852459 0.938099188946449 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 6/4880 36/18639 0.166666666666667 0.636577868852459 0.938099188946449 1 GO:0015125 bile acid transmembrane transporter activity 3/4880 21/18639 0.142857142857143 0.545638173302108 0.940692831489622 1 GO:0003743 translation initiation factor activity 9/4880 51/18639 0.176470588235294 0.67402362584378 0.944439517503635 1 GO:0004222 metalloendopeptidase activity 22/4880 110/18639 0.2 0.763893442622951 0.94724966046468 1 GO:0008186 ATP-dependent activity, acting on RNA 15/4880 79/18639 0.189873417721519 0.725215293629384 0.947751117876352 1 GO:0042910 xenobiotic transmembrane transporter activity 5/4880 32/18639 0.15625 0.59679175204918 0.947865870553966 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 17/4880 88/18639 0.193181818181818 0.73785162071535 0.947918839243554 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/4880 16/18639 0.125 0.477433401639344 0.948182205974779 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 2/4880 16/18639 0.125 0.477433401639344 0.948182205974779 1 GO:0043023 ribosomal large subunit binding 2/4880 16/18639 0.125 0.477433401639344 0.948182205974779 1 GO:0016859 cis-trans isomerase activity 7/4880 42/18639 0.166666666666667 0.636577868852459 0.949017139140755 1 GO:0042056 chemoattractant activity 7/4880 42/18639 0.166666666666667 0.636577868852459 0.949017139140755 1 GO:0008395 steroid hydroxylase activity 4/4880 27/18639 0.148148148148148 0.565846994535519 0.949050421917063 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 35/4880 167/18639 0.209580838323353 0.800487140473152 0.951256284226946 1 GO:0003796 lysozyme activity 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0005337 nucleoside transmembrane transporter activity 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0008519 ammonium channel activity 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0015203 polyamine transmembrane transporter activity 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0016427 tRNA (cytidine) methyltransferase activity 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0031720 haptoglobin binding 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0042166 acetylcholine binding 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0051378 serotonin binding 1/4880 10/18639 0.1 0.381946721311475 0.951996755646747 1 GO:0034062 5'-3' RNA polymerase activity 3/4880 22/18639 0.136363636363636 0.520836438152012 0.952470230810458 1 GO:0097747 RNA polymerase activity 3/4880 22/18639 0.136363636363636 0.520836438152012 0.952470230810458 1 GO:0140299 molecular sensor activity 13/4880 71/18639 0.183098591549296 0.699339067190025 0.954727566958911 1 GO:0005245 voltage-gated calcium channel activity 7/4880 43/18639 0.162790697674419 0.621773732367518 0.956941938699515 1 GO:0005200 structural constituent of cytoskeleton 22/4880 112/18639 0.196428571428571 0.750252488290398 0.957637665066211 1 GO:0015085 calcium ion transmembrane transporter activity 30/4880 147/18639 0.204081632653061 0.779483104717297 0.957719486722333 1 GO:0016866 intramolecular transferase activity 4/4880 28/18639 0.142857142857143 0.545638173302108 0.958461037647543 1 GO:0017046 peptide hormone binding 9/4880 53/18639 0.169811320754717 0.648588772038354 0.959180732679448 1 GO:0008569 minus-end-directed microtubule motor activity 2/4880 17/18639 0.117647058823529 0.449349083895853 0.959725870377453 1 GO:0030548 acetylcholine receptor regulator activity 2/4880 17/18639 0.117647058823529 0.449349083895853 0.959725870377453 1 GO:0032977 membrane insertase activity 2/4880 17/18639 0.117647058823529 0.449349083895853 0.959725870377453 1 GO:0070402 NADPH binding 2/4880 17/18639 0.117647058823529 0.449349083895853 0.959725870377453 1 GO:0070492 oligosaccharide binding 2/4880 17/18639 0.117647058823529 0.449349083895853 0.959725870377453 1 GO:0099186 structural constituent of postsynapse 3/4880 23/18639 0.130434782608696 0.498191375623664 0.962031578682571 1 GO:0008168 methyltransferase activity 43/4880 204/18639 0.21078431372549 0.805083775313404 0.962162742476802 1 GO:0140223 general transcription initiation factor activity 12/4880 68/18639 0.176470588235294 0.67402362584378 0.963934550520249 1 GO:0005004 GPI-linked ephrin receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0005008 hepatocyte growth factor receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0005009 insulin receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0005011 macrophage colony-stimulating factor receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0005020 stem cell factor receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0008288 boss receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0036332 placental growth factor receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0038062 protein tyrosine kinase collagen receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0060175 brain-derived neurotrophic factor receptor activity 8/4880 49/18639 0.163265306122449 0.623586483773837 0.964276858058007 1 GO:0015020 glucuronosyltransferase activity 5/4880 34/18639 0.147058823529412 0.561686354869817 0.964410269459945 1 GO:0019825 oxygen binding 5/4880 34/18639 0.147058823529412 0.561686354869817 0.964410269459945 1 GO:0005536 D-glucose binding 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:0008046 axon guidance receptor activity 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:0015217 ADP transmembrane transporter activity 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:0031731 CCR6 chemokine receptor binding 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:0035252 UDP-xylosyltransferase activity 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:0042285 xylosyltransferase activity 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:1990948 ubiquitin ligase inhibitor activity 1/4880 11/18639 0.0909090909090909 0.347224292101341 0.964571549379308 1 GO:0008083 growth factor activity 33/4880 162/18639 0.203703703703704 0.778039617486339 0.965232318913256 1 GO:0008237 metallopeptidase activity 38/4880 184/18639 0.206521739130435 0.788803011404134 0.966578958439095 1 GO:0008094 ATP-dependent activity, acting on DNA 44/4880 210/18639 0.20952380952381 0.800269320843091 0.967443745131011 1 GO:0005506 iron ion binding 31/4880 154/18639 0.201298701298701 0.76885378965297 0.967525007120733 1 GO:0000400 four-way junction DNA binding 2/4880 18/18639 0.111111111111111 0.424385245901639 0.968778181153538 1 GO:0003746 translation elongation factor activity 2/4880 18/18639 0.111111111111111 0.424385245901639 0.968778181153538 1 GO:0005372 water transmembrane transporter activity 2/4880 18/18639 0.111111111111111 0.424385245901639 0.968778181153538 1 GO:0017128 phospholipid scramblase activity 2/4880 18/18639 0.111111111111111 0.424385245901639 0.968778181153538 1 GO:0070628 proteasome binding 2/4880 18/18639 0.111111111111111 0.424385245901639 0.968778181153538 1 GO:0015078 proton transmembrane transporter activity 38/4880 185/18639 0.205405405405405 0.78453921134249 0.969538169371034 1 GO:0048027 mRNA 5'-UTR binding 3/4880 24/18639 0.125 0.477433401639344 0.969760100086443 1 GO:0005006 epidermal growth factor receptor activity 8/4880 50/18639 0.16 0.611114754098361 0.969769023178556 1 GO:0005007 fibroblast growth factor receptor activity 8/4880 50/18639 0.16 0.611114754098361 0.969769023178556 1 GO:0017171 serine hydrolase activity 41/4880 198/18639 0.207070707070707 0.790899776453055 0.969792826601268 1 GO:0140662 ATP-dependent protein folding chaperone 6/4880 40/18639 0.15 0.572920081967213 0.96979511670767 1 GO:0180051 translation factor activity 15/4880 84/18639 0.178571428571429 0.682047716627635 0.972851621926575 1 GO:0004032 aldose reductase (NADPH) activity 1/4880 12/18639 0.0833333333333333 0.31828893442623 0.973852784027632 1 GO:1990817 poly(A) RNA polymerase activity 1/4880 12/18639 0.0833333333333333 0.31828893442623 0.973852784027632 1 GO:0044183 protein folding chaperone 13/4880 75/18639 0.173333333333333 0.662040983606557 0.974107783351228 1 GO:0005030 neurotrophin receptor activity 8/4880 51/18639 0.156862745098039 0.599132111861138 0.974481489350634 1 GO:0046906 tetrapyrrole binding 30/4880 152/18639 0.197368421052632 0.753842213114754 0.974562572550827 1 GO:0003756 protein disulfide isomerase activity 2/4880 19/18639 0.105263157894737 0.402049180327869 0.975852124632669 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/4880 19/18639 0.105263157894737 0.402049180327869 0.975852124632669 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/4880 19/18639 0.105263157894737 0.402049180327869 0.975852124632669 1 GO:0030506 ankyrin binding 2/4880 19/18639 0.105263157894737 0.402049180327869 0.975852124632669 1 GO:0034987 immunoglobulin receptor binding 2/4880 19/18639 0.105263157894737 0.402049180327869 0.975852124632669 1 GO:0005251 delayed rectifier potassium channel activity 3/4880 25/18639 0.12 0.45833606557377 0.975982321289073 1 GO:0015271 outward rectifier potassium channel activity 3/4880 25/18639 0.12 0.45833606557377 0.975982321289073 1 GO:0017056 structural constituent of nuclear pore 3/4880 25/18639 0.12 0.45833606557377 0.975982321289073 1 GO:0015399 primary active transmembrane transporter activity 33/4880 166/18639 0.198795180722892 0.759291674896307 0.976654742597247 1 GO:0016853 isomerase activity 36/4880 180/18639 0.2 0.763893442622951 0.978631202978757 1 GO:0099095 ligand-gated monoatomic anion channel activity 7/4880 47/18639 0.148936170212766 0.568856818974538 0.978686412238837 1 GO:0022853 active monoatomic ion transmembrane transporter activity 22/4880 118/18639 0.186440677966102 0.712104056682412 0.978897519172249 1 GO:0016741 transferase activity, transferring one-carbon groups 44/4880 215/18639 0.204651162790698 0.78165840640488 0.979197506490098 1 GO:0008307 structural constituent of muscle 6/4880 42/18639 0.142857142857143 0.545638173302108 0.979254623218363 1 GO:0008236 serine-type peptidase activity 39/4880 194/18639 0.201030927835052 0.767831037688018 0.980479120752113 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/4880 13/18639 0.0769230769230769 0.293805170239597 0.980702969991295 1 GO:0009982 pseudouridine synthase activity 1/4880 13/18639 0.0769230769230769 0.293805170239597 0.980702969991295 1 GO:0019104 DNA N-glycosylase activity 1/4880 13/18639 0.0769230769230769 0.293805170239597 0.980702969991295 1 GO:0015081 sodium ion transmembrane transporter activity 32/4880 164/18639 0.195121951219512 0.745261895241903 0.98181653077584 1 GO:0005003 ephrin receptor activity 8/4880 53/18639 0.150943396226415 0.576523352922982 0.981948675046719 1 GO:0005005 transmembrane-ephrin receptor activity 8/4880 53/18639 0.150943396226415 0.576523352922982 0.981948675046719 1 GO:0020037 heme binding 27/4880 142/18639 0.190140845070423 0.726236723620411 0.982287597721512 1 GO:0016829 lyase activity 40/4880 200/18639 0.2 0.763893442622951 0.983372253879753 1 GO:0008135 translation factor activity, RNA binding 14/4880 83/18639 0.168674698795181 0.6442474817302 0.983885608544118 1 GO:0015252 proton channel activity 3/4880 27/18639 0.111111111111111 0.424385245901639 0.984963971225179 1 GO:0005248 voltage-gated sodium channel activity 2/4880 21/18639 0.0952380952380952 0.363758782201405 0.985643963214782 1 GO:0009975 cyclase activity 2/4880 21/18639 0.0952380952380952 0.363758782201405 0.985643963214782 1 GO:0051428 peptide hormone receptor binding 2/4880 21/18639 0.0952380952380952 0.363758782201405 0.985643963214782 1 GO:0008331 high voltage-gated calcium channel activity 1/4880 14/18639 0.0714285714285714 0.272819086651054 0.985758779421257 1 GO:0008392 arachidonate epoxygenase activity 1/4880 14/18639 0.0714285714285714 0.272819086651054 0.985758779421257 1 GO:0030983 mismatched DNA binding 1/4880 14/18639 0.0714285714285714 0.272819086651054 0.985758779421257 1 GO:0032036 myosin heavy chain binding 1/4880 14/18639 0.0714285714285714 0.272819086651054 0.985758779421257 1 GO:0061783 peptidoglycan muralytic activity 1/4880 14/18639 0.0714285714285714 0.272819086651054 0.985758779421257 1 GO:1901474 azole transmembrane transporter activity 1/4880 14/18639 0.0714285714285714 0.272819086651054 0.985758779421257 1 GO:1990825 sequence-specific mRNA binding 1/4880 14/18639 0.0714285714285714 0.272819086651054 0.985758779421257 1 GO:0030547 signaling receptor inhibitor activity 6/4880 44/18639 0.136363636363636 0.520836438152012 0.985894128465247 1 GO:0005242 inward rectifier potassium channel activity 3/4880 28/18639 0.107142857142857 0.409228629976581 0.988144323254496 1 GO:0051539 4 iron, 4 sulfur cluster binding 6/4880 45/18639 0.133333333333333 0.509262295081967 0.988409266001903 1 GO:0008175 tRNA methyltransferase activity 4/4880 34/18639 0.117647058823529 0.449349083895853 0.988510150183349 1 GO:0008649 rRNA methyltransferase activity 2/4880 22/18639 0.0909090909090909 0.347224292101341 0.988961336455215 1 GO:0016836 hydro-lyase activity 9/4880 61/18639 0.147540983606557 0.563527949475947 0.989209421184999 1 GO:0051536 iron-sulfur cluster binding 12/4880 76/18639 0.157894736842105 0.603073770491803 0.989269541405429 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/4880 40/18639 0.125 0.477433401639344 0.989404627763704 1 GO:0071855 neuropeptide receptor binding 5/4880 40/18639 0.125 0.477433401639344 0.989404627763704 1 GO:0004089 carbonate dehydratase activity 1/4880 15/18639 0.0666666666666667 0.254631147540984 0.989490170370211 1 GO:0004129 cytochrome-c oxidase activity 1/4880 15/18639 0.0666666666666667 0.254631147540984 0.989490170370211 1 GO:0010181 FMN binding 1/4880 15/18639 0.0666666666666667 0.254631147540984 0.989490170370211 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/4880 15/18639 0.0666666666666667 0.254631147540984 0.989490170370211 1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/4880 15/18639 0.0666666666666667 0.254631147540984 0.989490170370211 1 GO:0045504 dynein heavy chain binding 1/4880 15/18639 0.0666666666666667 0.254631147540984 0.989490170370211 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/4880 15/18639 0.0666666666666667 0.254631147540984 0.989490170370211 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 6/4880 46/18639 0.130434782608696 0.498191375623664 0.990497097984172 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/4880 46/18639 0.130434782608696 0.498191375623664 0.990497097984172 1 GO:0016500 protein-hormone receptor activity 10/4880 67/18639 0.149253731343284 0.57006973330071 0.990824620129046 1 GO:0051540 metal cluster binding 12/4880 77/18639 0.155844155844156 0.595241643602299 0.990858886065085 1 GO:0016887 ATP hydrolysis activity 89/4880 417/18639 0.213429256594724 0.815186047883005 0.991152925402071 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/4880 23/18639 0.0869565217391304 0.332127583749109 0.991526075290705 1 GO:0140102 catalytic activity, acting on a rRNA 2/4880 23/18639 0.0869565217391304 0.332127583749109 0.991526075290705 1 GO:0003688 DNA replication origin binding 1/4880 16/18639 0.0625 0.238716700819672 0.99224403466324 1 GO:0008391 arachidonate monooxygenase activity 1/4880 16/18639 0.0625 0.238716700819672 0.99224403466324 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 4/4880 36/18639 0.111111111111111 0.424385245901639 0.992656833616404 1 GO:0098918 structural constituent of synapse 3/4880 30/18639 0.1 0.381946721311475 0.992675074885387 1 GO:0016835 carbon-oxygen lyase activity 12/4880 79/18639 0.151898734177215 0.580172234903507 0.993401700376296 1 GO:0140612 DNA damage sensor activity 2/4880 24/18639 0.0833333333333333 0.31828893442623 0.993504800309274 1 GO:0036002 pre-mRNA binding 8/4880 59/18639 0.135593220338983 0.51789385940539 0.993938326731957 1 GO:0019843 rRNA binding 9/4880 65/18639 0.138461538461538 0.528849306431274 0.9947261623684 1 GO:0046873 metal ion transmembrane transporter activity 95/4880 450/18639 0.211111111111111 0.806331967213115 0.995074842841564 1 GO:0004497 monooxygenase activity 17/4880 106/18639 0.160377358490566 0.612556062480668 0.995488519047295 1 GO:0015280 ligand-gated sodium channel activity 1/4880 18/18639 0.0555555555555556 0.21219262295082 0.995776316329782 1 GO:0022851 GABA-gated chloride ion channel activity 1/4880 18/18639 0.0555555555555556 0.21219262295082 0.995776316329782 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/4880 18/18639 0.0555555555555556 0.21219262295082 0.995776316329782 1 GO:0042923 neuropeptide binding 3/4880 33/18639 0.0909090909090909 0.347224292101341 0.996491606055488 1 GO:0015079 potassium ion transmembrane transporter activity 28/4880 160/18639 0.175 0.668406762295082 0.996530831923139 1 GO:0004890 GABA-A receptor activity 1/4880 19/18639 0.0526315789473684 0.201024590163934 0.996883215868511 1 GO:0004252 serine-type endopeptidase activity 31/4880 176/18639 0.176136363636364 0.672747065946349 0.997339779634052 1 GO:0004812 aminoacyl-tRNA ligase activity 4/4880 41/18639 0.0975609756097561 0.372630947620952 0.997681779628818 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 4/4880 41/18639 0.0975609756097561 0.372630947620952 0.997681779628818 1 GO:0000049 tRNA binding 11/4880 80/18639 0.1375 0.525176741803279 0.997691316902836 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/4880 20/18639 0.05 0.190973360655738 0.997700074437881 1 GO:0008527 taste receptor activity 2/4880 28/18639 0.0714285714285714 0.272819086651054 0.997787388930669 1 GO:0070182 DNA polymerase binding 1/4880 21/18639 0.0476190476190476 0.181879391100703 0.998302879999035 1 GO:1904047 S-adenosyl-L-methionine binding 1/4880 21/18639 0.0476190476190476 0.181879391100703 0.998302879999035 1 GO:0016874 ligase activity 28/4880 167/18639 0.167664670658683 0.640389712378522 0.998625573975895 1 GO:0030280 structural constituent of skin epidermis 3/4880 37/18639 0.0810810810810811 0.309686530793088 0.998713652918651 1 GO:0008173 RNA methyltransferase activity 8/4880 67/18639 0.119402985074627 0.456055786640568 0.998725329827944 1 GO:0003823 antigen binding 29/4880 174/18639 0.166666666666667 0.636577868852459 0.998989868089342 1 GO:0005272 sodium channel activity 5/4880 51/18639 0.0980392156862745 0.374457569913211 0.99905480299504 1 GO:0016917 GABA receptor activity 1/4880 23/18639 0.0434782608695652 0.166063791874555 0.999075971774756 1 GO:0005179 hormone activity 20/4880 132/18639 0.151515151515152 0.578707153502235 0.999200576432786 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6/4880 58/18639 0.103448275862069 0.395117297908423 0.99924281881875 1 GO:0017069 snRNA binding 5/4880 54/18639 0.0925925925925926 0.353654371584699 0.999527066809655 1 GO:0008227 G protein-coupled amine receptor activity 3/4880 41/18639 0.0731707317073171 0.279473210715714 0.999538018815697 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 7/4880 68/18639 0.102941176470588 0.393180448408872 0.999689660966691 1 GO:0099094 ligand-gated monoatomic cation channel activity 19/4880 136/18639 0.139705882352941 0.533602037126326 0.999816791835548 1 GO:0022832 voltage-gated channel activity 26/4880 175/18639 0.148571428571429 0.567463700234192 0.99989747276226 1 GO:0005184 neuropeptide hormone activity 1/4880 31/18639 0.032258064516129 0.123208619777895 0.999918858246119 1 GO:0008188 neuropeptide receptor activity 3/4880 48/18639 0.0625 0.238716700819672 0.999926015461226 1 GO:0005244 voltage-gated monoatomic ion channel activity 25/4880 173/18639 0.144508670520231 0.551946129062826 0.99993655291549 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/4880 41/18639 0.0487804878048781 0.186315473810476 0.999939656591002 1 GO:0030515 snoRNA binding 1/4880 32/18639 0.03125 0.119358350409836 0.999940137897825 1 GO:0160041 neuropeptide activity 1/4880 32/18639 0.03125 0.119358350409836 0.999940137897825 1 GO:0140098 catalytic activity, acting on RNA 70/4880 387/18639 0.180878552971576 0.690859702630576 0.999942514237602 1 GO:0009055 electron transfer activity 14/4880 116/18639 0.120689655172414 0.46097018089316 0.999942975316295 1 GO:0008528 G protein-coupled peptide receptor activity 15/4880 122/18639 0.122950819672131 0.469606624563289 0.999948535420212 1 GO:0005267 potassium channel activity 15/4880 124/18639 0.120967741935484 0.462032324167107 0.999964740107095 1 GO:0003954 NADH dehydrogenase activity 2/4880 44/18639 0.0454545454545455 0.173612146050671 0.999974121896834 1 GO:0005249 voltage-gated potassium channel activity 10/4880 98/18639 0.102040816326531 0.389741552358648 0.999977851423424 1 GO:0001653 peptide receptor activity 15/4880 128/18639 0.1171875 0.447593814036885 0.99998363361145 1 GO:0140101 catalytic activity, acting on a tRNA 17/4880 139/18639 0.122302158273381 0.467129083618351 0.999983700151614 1 GO:0022834 ligand-gated channel activity 26/4880 188/18639 0.138297872340426 0.528224189047785 0.999987513622923 1 GO:0022843 voltage-gated monoatomic cation channel activity 17/4880 143/18639 0.118881118881119 0.454062535824831 0.99999234837887 1 GO:0015276 ligand-gated monoatomic ion channel activity 25/4880 186/18639 0.134408602150538 0.513369249074564 0.999992709416099 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 5/4880 73/18639 0.0684931506849315 0.261607343364024 0.999995312246253 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/4880 53/18639 0.0377358490566038 0.144130838230745 0.999998007157665 1 GO:0022824 transmitter-gated monoatomic ion channel activity 3/4880 63/18639 0.0476190476190476 0.181879391100703 0.999998707018894 1 GO:0022835 transmitter-gated channel activity 3/4880 63/18639 0.0476190476190476 0.181879391100703 0.999998707018894 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/4880 56/18639 0.0357142857142857 0.136409543325527 0.999999157727707 1 GO:0030594 neurotransmitter receptor activity 7/4880 97/18639 0.0721649484536082 0.275631654554673 0.999999630359394 1 GO:0098960 postsynaptic neurotransmitter receptor activity 3/4880 69/18639 0.0434782608695652 0.166063791874555 0.999999752340653 1 GO:0022836 gated channel activity 44/4880 318/18639 0.138364779874214 0.5284797401794 0.999999975201687 1 GO:0005216 monoatomic ion channel activity 70/4880 448/18639 0.15625 0.59679175204918 0.999999978161976 1 GO:0003730 mRNA 3'-UTR binding 33/4880 262/18639 0.125954198473282 0.481077931422851 0.999999980561512 1 GO:0005261 monoatomic cation channel activity 48/4880 341/18639 0.140762463343109 0.53763761357627 0.999999983759711 1 GO:0003735 structural constituent of ribosome 2/4880 175/18639 0.0114285714285714 0.0436510538641686 1 1 GO:0030371 translation repressor activity 15/4880 329/18639 0.0455927051671733 0.174139842543226 1 1 GO:0045182 translation regulator activity 20/4880 356/18639 0.0561797752808989 0.214576809725548 1 1 GO:1903231 mRNA base-pairing translational repressor activity 2/4880 298/18639 0.00671140939597315 0.0256340081417098 1 1