category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	66/944	250/9376	2.62210169491525	CTSD/VAMP8/CTSB/HEXB/CTSS/LAPTM5/LGMN/CD68/ATP6V0E1/ASAH1/CLTB/CTSL/ACP5/SLC17A5/ATP6V0D1/ATP6V1E1/LIPA/CLTA/CTSZ/ATP6V1D/IDS/SLC15A3/PSAP/GNPTG/ARL8A/SLC11A1/TLR3/ARSG/ATP6V1H/CTSO/SLC29A3/VAMP7/TPCN1/MITF/ROGDI/HEXA/ATP6V1G1/CTBS/RRAGD/LAPTM4A/GNS/AP1S2/ATP6V1B1/GPR155/BLOC1S2/ATP6V1C1/DTNBP1/TPP1/NAGLU/PLA2G15/CTSA/DMXL2/CLCN7/LAMP2/OSBPL2/HGSNAT/FIG4/SMPD1/RRAGB/MCOLN1/SLC11A2/ARSA/LAMTOR5/SCARB2/NPC1/PPT1	8.69789552091577
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	36/944	95/9376	3.76378233719893	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/CXCL2/CCL3/HLA-DQB1/ITGB2/ATP6V0E1/CXCL3/HLA-DMA/HLA-DQA1/IL1B/CTSL/ACP5/HLA-DMB/CCL20/ATP6V0D1/HLA-DQA2/ATP6V1E1/TNFSF13B/ATP6V1D/IL18/ICAM1/CD86/IL1A/CCL5/ATP6V1H/TNF/ATP6V1G1/HLA-DRB5/FLT1/ATP6V1B1/ATP6V1C1/VEGFA/CCL2	9.05888173115163
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	47/944	155/9376	3.0117003827228	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/CTSS/HLA-A/HLA-DQB1/ITGB2/ATP6V0E1/OLR1/HLA-DMA/MSR1/HLA-DQA1/FCGR3A/CTSL/HLA-DMB/NCF2/ATP6V0D1/HLA-DQA2/ATP6V1E1/STX7/ITGA2/CD14/CD36/ATP6V1D/HLA-F/CYBB/FCGR2A/FCGR1A/MARCO/ATP6V1H/ITGAM/PLA2R1/ATP6V1G1/NCF4/RAB5A/HLA-DRB5/RILP/TUBB2A/ATP6V1B1/ATP6V1C1/CORO1A/TUBA1A/LAMP2/CLEC7A/STX12	8.44980084364862
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	27/944	78/9376	3.4380704041721	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/ITGB2/HLA-DMA/NFKBIA/HLA-DQA1/FCGR3A/IL1B/HLA-DMB/EEF1A1/NCF2/HLA-DQA2/CYBB/FCGR2A/FCGR1A/IL1A/PTPN6/ITGAM/IFNGR1/TNF/NCF4/HLA-DRB5/PTGS2/STAT1	7.23444317038539
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	30/944	100/9376	2.97966101694915	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/CD59/HLA-DQB1/HLA-DMA/HLA-DQA1/IL1B/CD44/HLA-DMB/HLA-DQA2/CD37/ITGA2/CD14/CD36/CD4/FCGR1A/ITGA3/IL1A/CSF1R/ITGAM/CD9/TNF/CSF3R/HLA-DRB5/IL4R/IL11RA/CSF2RA/MME	6.65911933213212
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	47/944	205/9376	2.27713931376602	HLA-DRA/VIM/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/CDKN1A/HLA-DQB1/HLA-DMA/NFKBIA/HLA-DQA1/GADD45B/CD44/HLA-DMB/HLA-DQA2/CXCL10/HLA-F/TAPBPL/PLCG2/TRADD/ICAM1/PSMD7/SYK/BTK/FADD/TNF/CIR1/HLA-DRB5/PIK3CA/TRAF3/STAT1/TAPBP/OAS2/CD58/GADD45G/NEDD4/GADD45A/MAP2K3/NFKB2/DDB2/CDK6/BAX/RB1/CASP9/MDM2/STAT3	6.18604669704354
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	43/944	181/9376	2.35958423073321	HLA-DRA/CD74/CTSD/HLA-DRB1/HLA-DPA1/HLA-DPB1/CTSS/FCER1G/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/FCGR3A/IL1B/HLA-DMB/LSP1/ATP6V0D1/HLA-DQA2/CD14/IL18/TRADD/FCGR2A/FCGR1A/PLK3/IL1A/ITGAX/ATP6V1H/SYK/ITGAM/PLA2R1/IFNGR1/FADD/TNF/RAB5A/HLA-DRB5/STAT1/CORO1A/CALM2/LAMP2/CLEC7A/BAX/CREBBP/CASP9	6.17982071497739
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	42/944	180/9376	2.31751412429379	HLA-DRA/CD74/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/NFKBIA/HLA-DQA1/IL1B/HLA-DMB/SP100/HLA-DQA2/HLA-F/TAPBPL/TRADD/TNFRSF14/BIRC3/CCL5/TLR3/SYK/IFIH1/IFNGR1/PILRA/FADD/TNF/BCL2L1/POU2F3/HLA-DRB5/RNASEL/PIK3CA/TRAF3/STAT1/BST2/TAPBP/OAS2/CCL2/BAX/CASP9/EIF2B1	5.97170557470241
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	25/944	82/9376	3.02811078958247	HLA-DRA/CD74/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/CTSB/CTSS/LGMN/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/CTSL/HLA-DMB/HLA-DQA2/HLA-F/TAPBPL/CD4/HSPA6/TNF/HLA-DRB5/HSPA1A/IFI30/TAPBP	6.17168290077635
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	40/944	173/9376	2.2964632115215	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/NFKBIA/HLA-DQA1/IL1B/HLA-DMB/HLA-DQA2/TNFSF10/CXCL10/IL18/TRADD/ICAM1/CASP1/IL1A/CCL5/TLR3/IFIH1/IFNGR1/FADD/TNF/HLA-DRB5/RAB11B/RNASEL/MX2/PIK3CA/TRAF3/STAT1/CALCOCO2/OAS2/CCL2/CDK6/SLC25A5/BAX/CREBBP/DNAJB1/CASP9	5.75870557160233
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	30/944	112/9376	2.66041162227603	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/NFKBIA/LAMB4/HLA-DQA1/HLA-DMB/BIRC7/LY96/HLA-DQA2/ALOX5/BIRC3/HSPA6/IFNGR1/TNF/BCL2L1/HLA-DRB5/SOCS1/HSPA1A/LAMB3/PDPK1/LAMC2/STAT1/MAP2K3/LAMB2/CASP9/STAT3	5.9146879817408
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	63/944	333/9376	1.87906550618415	SPP1/FN1/HLA-B/HLA-A/CDKN1A/ATP6V0E1/ITGB6/LAMB4/PPP2R2B/ATP6V0D1/HES2/ATP6V1E1/WNT6/ITGA2/KRAS/ATP6V1D/IRF1/HLA-F/CREB5/WNT10A/TRADD/ITGA3/TCF7L1/PTGER4/TLR3/ITGB4/EGFR/ATP6V1H/WNT11/BCAP31/FADD/CTNNB1/TNF/ATP6V1G1/NOTCH3/PTGS2/NOTCH2/CRB3/FZD5/JAG1/LAMB3/MAML2/MX2/PIK3CA/TRAF3/LAMC2/STAT1/ATP6V1B1/ATP6V1C1/VEGFA/SOS1/LLGL2/CREB3/CDK6/NOTCH1/LAMB2/BAX/SOS2/CREBBP/RB1/MDM2/PPP2CB/RBL2	5.4650410289187
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	17/944	44/9376	3.83744221879815	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/IL1B/HLA-DMB/HLA-DQA2/HLA-F/CD86/IL1A/TNF/HLA-DRB5	6.3120776956904
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	43/944	196/9376	2.17900380491179	HLA-B/CXCL2/HLA-A/CDKN1A/CXCL3/NFKBIA/RCAN1/GNG5/ZFP36/KRAS/MAP1LC3B/HLA-F/PLCG2/TRADD/CLEC2B/ICAM1/CD86/TCF7L1/NFATC2/IL6ST/TLR3/PDGFB/SYK/IFNGR1/FADD/CTNNB1/UBB/PTGS2/ITPR2/PIK3CA/TRAF3/STAT1/VEGFA/FGF2/CALM2/ANGPT2/CDK6/PREX1/BAX/CREBBP/RB1/CASP9/STAT3	5.5812083866526
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	29/944	109/9376	2.64251282848702	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/TGFBR1/HLA-DMA/NFKBIA/HLA-DQA1/IL1B/HLA-DMB/HLA-DQA2/CD4/EBI3/NFATC2/RUNX1/IL6ST/IFNGR1/STAT6/HLA-DRB5/AHR/IL1RAP/IL4R/SMAD4/STAT1/IL27/STAT5A/SMAD3/STAT3	5.77110231717157
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	17/944	45/9376	3.75216572504708	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/IL1B/HLA-DMB/HLA-DQA2/HLA-F/CD86/IL1A/TNF/HLA-DRB5	6.19188783415815
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	49/944	238/9376	2.04486540378863	RPS15A/RPL34/RPS14/RPS4Y1/RPS29/FAU/RPL23/RPS25/C1QB/C1QA/RPS28/RPS20/RPL36A/NFKBIA/RPL31/RPS27/RPL37/IL1B/RPS12/RPS21/RPL10A/C5AR1/C1QC/RPL30/RPLP2/RPL38/CXCL10/PLCG2/CYBB/FCGR2A/C3AR1/CASP1/IL6ST/TLR3/EGFR/SYK/IFIH1/HBEGF/TNF/C2/MX2/PIK3CA/TRAF3/STAT1/OAS2/CCL2/NRP1/F13A1/STAT3	5.46297971253754
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	27/944	99/9376	2.70878274268105	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/C1QB/C1QA/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/FCGR3A/HLA-DMB/KRT18/HLA-DQA2/C5AR1/C1QC/FPR3/KRT14/ICAM1/FCGR2A/C3AR1/FCGR1A/KRT23/ITGAM/C2/FPR1/HLA-DRB5	5.71882760365938
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	23/944	77/9376	2.96676205150781	CDKN2A/CDKN1A/TGFBR1/GADD45B/KRAS/RALGDS/PLD1/EGFR/BCL2L1/SMAD4/PIK3CA/STAT1/RAC2/GADD45G/VEGFA/GADD45A/DDB2/CDK6/BAX/SMAD3/RB1/CASP9/STAT3	5.7980959120276
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/944	248/9376	2.00246036085293	S100A10/ANXA2/DYNLRB1/MYL12A/NFKBIA/IL1B/DYNLT1/ARPC2/LY96/CASP4/TNFSF10/TXN/CD14/RAB9A/IL18/MYL12B/CYTH3/TRADD/PTPRC/RRAS/ARL8A/TCF7L1/CASP1/BIRC3/NCKAP1L/DYNLRB2/FADD/RHOB/CTNNB1/TNF/RAB5A/EXOC2/PIK3CA/RILP/TUBB2A/SKP1/TUBA1A/ABI1/SNX9/ARPC5/MAP2K3/MYL9/CYTH1/SNX33/ARPC1B/NAIP/CYTH2/BAX/PLEKHM2/MYO6	5.35317658833126
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	34/944	142/9376	2.37813320601576	TYROBP/TREM2/SQSTM1/TGFBR1/NFKBIA/FCGR3A/IL1B/ACP5/NCF2/SPI1/LILRB4/JUND/PLCG2/FCGR2A/FCGR1A/NFATC2/IL1A/JUNB/LCP2/CSF1R/SYK/BTK/IFNGR1/MITF/TNF/NCF4/SOCS1/ITPR2/PIK3CA/TMEM64/STAT1/NFKB2/FOSL2/FHL2	5.5366461784105
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	22/944	73/9376	2.99326677501741	CDKN2A/CDKN1A/GADD45B/KRAS/PLCG2/EGFR/PDPK1/PIK3CA/EML4/FHIT/GADD45G/SOS1/STAT5A/GADD45A/MET/DDB2/CDK6/BAX/SOS2/RB1/CASP9/STAT3	5.72033790569375
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	47/944	232/9376	2.01212741087084	FN1/TMSB4X/GSN/ITGB2/ITGB6/MYL12A/RGCC/SCIN/ARPC2/IQGAP2/BAIAP2/CXCR4/VAV3/ITGA2/KRAS/PIP5K1B/MRAS/MYL12B/PDGFA/RRAS/ITGA3/PPP1R12B/SSH3/ITGAX/FGF1/ITGB4/EGFR/PDGFB/BDKRB2/NCKAP1L/MYH10/ITGAM/BCAR1/DIAPH2/PIK3CA/LIMK2/FGFR2/RAC2/SOS1/FGF2/ARPC5/MYL9/SSH2/ARPC1B/VAV2/SOS2/FGD3	5.22296850411841
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	32/944	133/9376	2.38970307123742	GABARAPL1/GABARAPL2/CDKN1A/TGFBR1/FBXO32/GADD45B/PRKAB2/TNFSF10/HOMER3/GABARAP/FOXO4/KRAS/PLK3/EGFR/IRS2/CDKN2B/PRKAG2/CAT/PDPK1/SMAD4/PIK3CA/GADD45G/SOS1/GADD45A/BCL6/SOS2/SOD2/SMAD3/CREBBP/MDM2/STAT3/RBL2	5.40067070284582
Human Diseases	Immune disease	hsa05330	Allograft rejection	15/944	39/9376	3.82007822685789	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-F/CD86/TNF/HLA-DRB5	5.90467659708948
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	25/944	93/9376	2.6699471478039	FN1/CDKN1A/NFKBIA/LAMB4/GADD45B/BIRC7/ITGA2/ITGA3/BIRC3/CDKN2B/BCL2L1/PTGS2/LAMB3/PIK3CA/TRAF3/LAMC2/FHIT/GADD45G/GADD45A/DDB2/CDK6/LAMB2/BAX/RB1/CASP9	5.41509851291229
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	49/944	250/9376	1.94671186440678	HLA-B/HLA-A/TGFBR1/SH3KBP1/DAB2/SH3GLB2/CLTB/NEDD4L/ARPC2/FOLR1/TSG101/CXCR4/CLTA/PIP5K1B/HLA-F/CHMP5/CYTH3/RAB11FIP1/CHMP1B/HSPA6/ARFGAP3/PLD1/EGFR/ASAP2/SH3GL1/RAB5A/RAB11B/DNAJC6/CHMP1A/HSPA1A/RAB31/FGFR2/IST1/ARAP1/SMURF2/FOLR2/AGAP3/ARRB1/NEDD4/STAMBP/ARPC5/CYTH1/CHMP4C/ARPC1B/ARRB2/VPS37B/CYTH2/SMAD3/MDM2	5.07637770852077
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	27/944	105/9376	2.55399515738499	CXCL2/CXCL3/NFKBIA/BCL2A1/IL1B/GADD45B/UBE2I/LY96/TNFSF13B/CD14/PLAU/CCL4/PLCG2/TRADD/ICAM1/BIRC3/SYK/BTK/TNF/BCL2L1/PTGS2/TRAF3/PPP1R13L/GADD45G/GADD45A/NFKB2/CFLAR	5.35781059252413
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	32/944	137/9376	2.31993071879253	CTSD/CTSB/CTSS/PMAIP1/NFKBIA/BCL2A1/CTSL/GADD45B/TNFSF10/KRAS/CTSZ/CAPN2/BBC3/TRADD/NOL3/BIRC3/CTSO/MAP3K5/FADD/TNF/BCL2L1/ITPR2/PDPK1/PIK3CA/TUBA1A/GADD45G/LMNA/CSF2RB/GADD45A/CFLAR/BAX/CASP9	5.20721216070991
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	20/944	66/9376	3.00975860297894	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/IL1B/HLA-DMB/HLA-DQA2/IL18/IL1A/IFNGR1/TNF/STAT6/HLA-DRB5/IL4R/STAT1/SMAD3/STAT3	5.48210513445744
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/944	56/9376	3.19249394673123	CXCL2/ITGB2/CXCL3/NFKBIA/IL1B/EEF1A1/CD14/IL18/CASP1/HSPA6/ITGAM/TNF/HSPA1A/RAB1A/NFKB2/NAIP/EEF1G/CASP9	5.50593140817281
Human Diseases	Immune disease	hsa05310	Asthma	13/944	32/9376	4.03495762711864	HLA-DRA/PRG2/HLA-DRB1/HLA-DPA1/HLA-DPB1/FCER1G/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/TNF/HLA-DRB5	5.75396933034873
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	44/944	224/9376	1.95096852300242	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/CDKN2A/HLA-A/CDKN1A/HLA-DQB1/ITGB2/TGFBR1/HLA-DMA/NFKBIA/HLA-DQA1/HLA-DMB/HLA-DQA2/SPI1/ZFP36/KRAS/HLA-F/CREB5/CD4/ICAM1/MMP7/NFATC2/ETS2/CDKN2B/TNF/BCL2L1/HLA-DRB5/MSX2/SMAD4/PIK3CA/ADCY7/STAT5A/NRP1/NFKB2/EGR1/CREB3/SLC25A5/BAX/SMAD3/CREBBP/RB1	4.81990503889281
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	28/944	119/9376	2.3369890329013	CXCL2/CXCL3/NFKBIA/IL1B/MMP9/CCL20/CXCL10/IRF1/CREB5/TRADD/RHBDF1/ICAM1/BIRC3/JUNB/CCL5/MAP3K5/FADD/TNF/PTGS2/JAG1/PIK3CA/TRAF3/BCL3/CCL2/MAP2K3/TNFRSF1B/CREB3/CFLAR	4.91102935503175
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	21/944	77/9376	2.70878274268105	CDKN2A/CDKN1A/TGFBR1/NFKBIA/GADD45B/KRAS/RUNX1/BCL2L1/SMAD4/PIK3CA/GADD45G/SOS1/STAT5A/GADD45A/DDB2/CDK6/BAX/SOS2/SMAD3/RB1/MDM2	5.03756223447904
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	42/944	216/9376	1.93126177024482	CXCL2/CCL3/CXCL3/OLR1/NFKBIA/IL1B/MMP9/NFE2L2/LY96/NCF2/TNFSF10/ABCG1/VAV3/KRAS/CD14/ABCA1/CD36/IL18/ICAM1/CYBB/CASP1/NFATC2/HSPA6/CCL5/MAP3K5/TNF/BCL2L1/POU2F3/NCF4/HSPA1A/PDPK1/PIK3CA/TRAF3/CCL2/CALM2/MAP2K3/VLDLR/VAV2/BAX/SOD2/CASP9/STAT3	4.63294612545326
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	40/944	204/9376	1.94749086075108	FN1/TIMP3/IGF2/CDKN1A/CTSL/MMP9/CD44/PLAUR/WNT6/VAV3/ITGA2/KRAS/HCLS1/PDCD4/MRAS/PLAU/PLCG2/WNT10A/RRAS/PPP1R12B/PTPN6/EGFR/WNT11/HBEGF/SDC2/CTNNB1/TNF/ITPR2/FZD5/PDPK1/PIK3CA/VEGFA/SOS1/FRS2/FGF2/MET/VAV2/SOS2/MDM2/STAT3	4.57788023553324
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	43/944	227/9376	1.88143059807362	HLA-B/CDKN2A/CCL3/HLA-A/CDKN1A/NFKBIA/IL1B/GNG5/CXCR4/KRAS/CCL4/HLA-F/CREB5/TAPBPL/TRADD/NFATC2/PTGER4/CCL5/EGFR/AKAP13/BCAR1/FADD/CTNNB1/TNF/GNA11/PTGS2/ITPR2/PIK3CA/TAPBP/ADCY7/RAC2/VEGFA/SOS1/CCL2/CALM2/CREB3/CDK6/BAX/SOS2/RB1/CASP9/MDM2/STAT3	4.49801162778487
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/944	227/9376	1.88143059807362	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/GSTA3/GSTT1/NFKBIA/MT-CO3/NFE2L2/UQCRB/NCF2/HMOX1/KRAS/MT-ATP8/EPHX2/SOD1/PLD1/EGFR/UQCRQ/MAP3K5/CAT/PTPN1/AHR/NDUFAB1/PDPK1/PIK3CA/GSTM3/PTPRJ/NOX4/VEGFA/SOS1/UQCRC2/MET/SLC25A5/SOS2/SOD2	4.49801162778487
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/944	93/9376	2.45635137597959	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/NFKBIA/HLA-DQA1/HLA-DMB/HLA-DQA2/CD4/NFATC2/IFNGR1/STAT6/HLA-DRB5/NOTCH3/NOTCH2/JAG1/MAML2/IL4R/STAT1/STAT5A/NOTCH1	4.72247650514919
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	20/944	75/9376	2.64858757062147	SERPINE1/CDKN2A/CDKN1A/PMAIP1/GADD45B/SESN1/BBC3/BCL2L1/ZMAT3/PPP1R13L/RRM2B/GADD45G/GADD45A/DDB2/CDK6/PERP/PPM1D/BAX/CASP9/MDM2	4.7960551356029
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	22/944	87/9376	2.51159166179622	CDKN1A/PMAIP1/TGFBR1/GADD45B/KRAS/EREG/BBC3/RALGDS/TCF7L1/EGFR/CTNNB1/SMAD4/PIK3CA/RAC2/GADD45G/SOS1/GADD45A/DDB2/BAX/SOS2/SMAD3/CASP9	4.73931929653637
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	22/944	88/9376	2.48305084745763	SERPINE1/SERPINE2/CD59/C1QB/C1QA/ITGB2/CLU/SERPING1/F5/PLAUR/SERPINA1/C5AR1/C1QC/PLAU/C3AR1/A2M/ITGAX/BDKRB2/ITGAM/VSIG4/C2/F13A1	4.67673336886444
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	52/944	300/9376	1.72158192090395	IGF2/DUSP9/DUSP1/TGFBR1/IL1B/GADD45B/DUSP2/KRAS/EREG/CD14/MRAS/JUND/PDGFA/TRADD/RRAS/EFNA5/HSPB1/EFNA1/HSPA6/IL1A/FGF1/EGFR/PDGFB/CACNA2D3/CSF1R/CACNG4/RASA1/MAP3K5/TNF/DUSP10/IL1RAP/RASGRF2/HSPA1A/FGFR2/FLT1/RAC2/MAPKAPK3/GADD45G/VEGFA/ARRB1/SOS1/FGF2/ANGPT2/GADD45A/MAP2K3/NFKB2/MAPK8IP3/MET/ARRB2/RASA2/SOS2/NTF4	4.25016082226134
Human Diseases	Cancer: specific types	hsa05218	Melanoma	19/944	73/9376	2.58509403296958	CDKN2A/CDKN1A/GADD45B/KRAS/PDGFA/FGF1/EGFR/PDGFB/MITF/PIK3CA/GADD45G/FGF2/GADD45A/MET/DDB2/CDK6/BAX/RB1/MDM2	4.5489512967002
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	51/944	298/9376	1.69980662040723	CSH1/CSH2/CXCL2/CCL3/TGFBR1/CXCL3/TNFRSF12A/IL1B/CXCL16/CXCR6/CCL20/CCL18/CXCR4/TNFSF10/IL1RN/TNFSF13B/CXCL10/IL18/CXCL9/CCL4/IL32/CD4/TNFRSF14/OSM/EBI3/GDF15/IL1A/CCL5/IL6ST/GH2/CSF1R/ACKR3/IFNGR1/TNF/TNFRSF21/CSF3R/OSMR/IL1RAP/IL4R/INHBA/TNFRSF10C/BMPR2/IL27/CCL2/CSF2RB/TNFRSF1B/TNFSF12/IL11RA/INHA/CCL28/CSF2RA	4.10768777968563
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	45/944	253/9376	1.76659744087894	SQSTM1/MYL12A/NFKBIA/IL1B/CD44/ARPC2/CASP4/CAST/WIPI1/FOXO4/MAP1LC3B/CD14/HCLS1/IL18/MYL12B/CYTH3/CAPN2/PLCG2/TRADD/CASP1/CCL5/EGFR/FNBP1L/BCAR1/PLCD3/TNF/BCL2L1/RRAGD/UBB/CAPNS1/ITPR2/PIK3CA/CALCOCO2/SKP1/ARPC5/TNIP1/MYL9/ARHGEF2/CYTH1/ARPC1B/RRAGB/NAIP/CYTH2/BAX/MDM2	4.13585328946234
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	24/944	106/9376	2.24880076750879	CDKN1A/NFKBIA/MMP9/FOLR1/KRAS/PLAU/PDGFA/CREB5/TCF7L1/EGFR/PDGFB/SPINT1/CTNNB1/PDPK1/PIK3CA/FGFR2/FOLR2/SOS1/CREB3/SOS2/CREBBP/RB1/CASP9/MDM2	4.3262594300503
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	23/944	101/9376	2.26178889075348	FN1/SERPINE1/TGFBR1/IL1B/PIM1/KRAS/PLCG2/ICAM1/CYBB/IL1A/PLCD3/TNF/SMAD4/PIK3CA/STAT1/NOX4/VEGFA/CCL2/STAT5A/EGR1/BAX/SMAD3/STAT3	4.26576339869959
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/944	76/9376	2.48305084745763	CDKN2A/CDKN1A/GADD45B/KRAS/PDGFA/PLCG2/EGFR/PDGFB/PIK3CA/GADD45G/SOS1/CALM2/GADD45A/DDB2/CDK6/BAX/SOS2/RB1/MDM2	4.34337872428427
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	18/944	70/9376	2.55399515738499	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-F/ICAM1/CD86/HLA-DRB5/RAC2/CASP9	4.36639974965968
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/944	142/9376	2.02840773454285	GSTA3/GSTT1/DUSP1/SQSTM1/IL1B/CTSL/MMP9/NFE2L2/NCF2/HMOX1/TXN/PDGFA/ICAM1/ASS1/IL1A/PDGFB/MAP3K5/SDC2/CTNNB1/TNF/PIK3CA/GSTM3/BMPR2/RAC2/VEGFA/CCL2/CALM2/ARHGEF2/MEF2A	4.13162510594014
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	33/944	170/9376	1.92801595214357	IGF2/CDKN2A/GSTA3/CDKN1A/GSTT1/TGFBR1/GADD45B/NFE2L2/HMOX1/WNT6/KRAS/PLCG2/WNT10A/TCF7L1/EGFR/WNT11/CTNNB1/BCL2L1/BRD7/FZD5/SMAD4/PIK3CA/GSTM3/GADD45G/SOS1/GADD45A/MET/DDB2/CDK6/BAX/SOS2/SMAD3/RB1	4.08555210296539
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	29/944	144/9376	2.00023540489642	CXCL2/C1QB/C1QA/CXCL3/NFKBIA/ACADVL/IL1B/LY96/PRKAB2/C5AR1/LPIN2/C1QC/CD14/TRADD/C3AR1/TCF7L1/SCD5/PRKAG2/MAP3K5/FADD/CTNNB1/TNF/C2/ADIPOR1/TRAF3/NOX4/MLYCD/MAP2K3/ACOX1	4.04708110194334
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	23/944	105/9376	2.17562550443906	GABARAPL1/GABARAPL2/SQSTM1/OPTN/PINK1/GABARAP/KRAS/MAP1LC3B/ATG9B/MRAS/RRAS/AMFR/MITF/BCL2L1/ULK1/CITED2/RAB5A/UBB/CALCOCO2/SMURF2/CCZ1B/TBC1D17/FIS1	4.05328082947473
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	23/944	105/9376	2.17562550443906	FCER1G/NFKBIA/IL1B/LSP1/KRAS/MRAS/IRF1/PLCG2/RRAS/PLK3/CASP1/NFATC2/SYK/TNF/PTGS2/ITPR2/PIK3CA/STAT1/BCL3/CALM2/NFKB2/CLEC7A/MDM2	4.05328082947473
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	32/944	168/9376	1.89184826472962	CSH1/CSH2/CDKN1A/PIM1/PDGFA/OSM/PTPN6/IL6ST/EGFR/PDGFB/GH2/IFNGR1/BCL2L1/STAT6/CISH/CSF3R/SOCS2/OSMR/SOCS1/IL4R/PIK3CA/STAT1/IL27/SOS1/CSF2RB/STAT5A/IL11RA/PIAS1/CSF2RA/SOS2/CREBBP/STAT3	3.90273707048513
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	14/944	50/9376	2.78101694915254	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/CXCR4/TNFSF13B/CD86/HLA-DRB5/CCL28	4.22485380584263
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	17/944	69/9376	2.44706460329157	FCER1G/ALOX5AP/VAV3/KRAS/PLCG2/ALOX5/LCP2/SYK/BTK/TNF/PDPK1/PIK3CA/RAC2/SOS1/MAP2K3/VAV2/SOS2	4.03658354217791
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	30/944	157/9376	1.89787325920328	SERPINE1/HLA-B/CDKN2A/HLA-A/CDKN1A/SQSTM1/TGFBR1/GADD45B/KRAS/MRAS/HLA-F/CAPN2/RRAS/E2F4/NFATC2/IL1A/CDKN2B/ITPR2/PIK3CA/GADD45G/HIPK2/CALM2/GADD45A/MAP2K3/CDK6/SLC25A5/SMAD3/RB1/MDM2/RBL2	3.79602699817165
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	17/944	71/9376	2.37813320601576	CXCL2/ATP6V0E1/CXCL3/NFKBIA/ATP6V0D1/ATP6V1E1/ATP6V1D/PLCG2/TJP1/CCL5/EGFR/ATP6V1H/HBEGF/ATP6V1G1/ATP6V1B1/ATP6V1C1/MET	3.90003513160106
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/944	59/9376	2.52513645504165	CDKN1A/GADD45B/KRAS/TCF7L1/EGFR/CTNNB1/PDPK1/PIK3CA/GADD45G/SOS1/GADD45A/DDB2/BAX/SOS2/CASP9	3.93190482243821
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	21/944	98/9376	2.12832929782082	GSN/SCIN/FCGR3A/MARCKS/ARPC2/VAV3/PIP5K1B/PLCG2/PTPRC/FCGR2A/FCGR1A/PLD1/ASAP2/SYK/INPPL1/PIK3CA/LIMK2/RAC2/ARPC5/ARPC1B/VAV2	3.75688633125645
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/944	42/9376	2.83777239709443	SLC40A1/FTL/GPX4/FTH1/LPCAT3/HMOX1/MAP1LC3B/CYBB/ACSL3/PRNP/SLC39A8/SLC11A2	3.99382294363109
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	31/944	169/9376	1.82188346203992	GABARAPL1/CTSD/VAMP8/GABARAPL2/CTSB/SQSTM1/CTSL/OPTN/WIPI1/GABARAP/STX7/KRAS/MAP1LC3B/ATG9B/MRAS/RRAS/IRS2/BCL2L1/ULK1/RRAGD/UBB/PDPK1/PIK3CA/CALCOCO2/C9orf72/RAB1A/DAPK1/LAMP2/RRAGB/CFLAR/PPP2CB	3.60745447220275
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	45/944	275/9376	1.62526964560863	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/C1QB/C1QA/MT-CO3/IL1B/UQCRB/NCF2/C1QC/MT-ATP8/CREB5/CYBB/SOD1/PSMD7/HSPA6/IL1A/CCL5/UQCRQ/PRNP/TNF/PSMB2/NCF4/NDUFAB1/HSPA1A/ITPR2/PIK3CA/TUBB2A/RAC2/TUBA1A/UQCRC2/EGR1/CREB3/NOTCH1/SLC25A5/BAX/CASP9	3.52123874654409
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/944	54/9376	2.57501569365976	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-F/CD86/HLA-DRB5	3.88359159535421
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	35/944	200/9376	1.73813559322034	NFKBIA/IL1B/ARPC2/CASP4/BAIAP2/TNFSF10/HCLS1/IL18/CYTH3/TRADD/FCGR2A/CASP1/TJP1/PTPN6/NCKAP1L/MYH10/CLDN23/MYO5B/FADD/TNF/TUBB2A/TUBA1A/RAB1A/ABI1/ARPC5/ARHGEF2/CYTH1/ARPC1B/MYO1D/NAIP/CYTH2/BAX/CASP9/NCK2/MYO6	3.53045580685247
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/944	156/9376	1.84637114298131	CDKN1A/NFKBIA/PPP2R2B/KRAS/CXCL10/TRADD/TLR3/EGFR/CLDN23/FADD/CTNNB1/TNF/RNASEL/MX2/PIK3CA/IFIT1/TRAF3/STAT1/OAS2/SOS1/PIAS1/CDK6/CFLAR/BAX/SOS2/RB1/CASP9/STAT3/PPP2CB	3.5666789836745
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	21/944	100/9376	2.08576271186441	CXCL2/CCL3/CXCL3/CCL20/CCL18/CXCR4/TNFSF10/CXCL10/IL18/CXCL9/CCL4/TNFRSF14/CCL5/IL6ST/CSF1R/ACKR3/TNF/TNFRSF10C/CCL2/TNFRSF1B/CCL28	3.65225329123616
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/944	68/9376	2.3369890329013	BCL2A1/SPI1/PIM1/KRAS/CD14/FCGR1A/TCF7L1/RUNX1/CSF1R/ITGAM/PIK3CA/CEBPA/SOS1/STAT5A/SOS2/STAT3	3.70220489155254
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	18/944	83/9376	2.15397181948132	PRDX5/ECH1/CROT/PRDX1/EPHX2/SOD1/SCP2/ACSL3/DECR2/PEX6/CAT/GSTK1/PEX11B/MLYCD/ACOX1/PEX2/PEX3/SOD2	3.53315440526612
NA	NA	hsa04518	Integrin signaling	28/944	154/9376	1.80585516178737	SPP1/FN1/ITGB2/FBN1/ITGB6/LAMB4/ITGA2/PDGFA/FERMT3/ICAM1/ITGA3/PARVG/ITGAX/ITGB4/EGFR/PDGFB/ITGAM/NPNT/CTNNB1/LAMB3/PIK3CA/LAMC2/FLT1/RAC2/VEGFA/MET/LAMB2/NCK2	3.37373626864861
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	30/944	170/9376	1.75274177467597	MYL12A/PPP2R2B/NEDD4L/ARPC2/PRKAB2/SYNPO/MYL6/HCLS1/MYL12B/AMOTL2/TJP1/AMOT/RUNX1/MYH10/CLDN23/PRKAG2/MAP3K5/CRB3/TUBA1A/NEDD4/TJP2/ARPC5/MYL9/LLGL2/ARHGEF2/CGN/ARPC1B/SYMPK/PPP2CB/AMOTL1	3.31391473757936
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	27/944	148/9376	1.81195602382043	CDKN1A/GADD45B/WNT6/KRAS/WNT10A/TCF7L1/FGF1/EGFR/WNT11/CTNNB1/NOTCH3/NOTCH2/FZD5/JAG1/PIK3CA/GADD45G/SOS1/FGF2/GADD45A/NFKB2/DDB2/NCOA3/CDK6/NOTCH1/BAX/SOS2/RB1	3.33131660321665
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	32/944	187/9376	1.69962838756458	GABARAPL1/GABARAPL2/CTSB/CXCL2/GBP2/CXCL3/NFKBIA/GBP3/IL1B/CASP4/GBP1/IFI16/GABARAP/TXN/MAP1LC3B/IL18/CYBB/GPSM3/CASP1/BIRC3/CCL5/CARD16/FADD/TNF/BCL2L1/RNASEL/ITPR2/TRAF3/STAT1/OAS2/CCL2/NAIP	3.233407465226
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	34/944	203/9376	1.66352175002087	SPP1/FN1/ITGB6/MYL12A/LAMB4/VAV3/ITGA2/PIP5K1B/MYL12B/PDGFA/CAPN2/ZYX/ITGA3/BIRC3/PPP1R12B/PARVG/ITGB4/EGFR/PDGFB/BCAR1/CTNNB1/LAMB3/PDPK1/PIK3CA/LAMC2/FLT1/RAC2/VEGFA/SOS1/MYL9/MET/LAMB2/VAV2/SOS2	3.19781858404005
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/944	93/9376	2.02915983233096	TGFBR1/MYL12A/BAIAP2/MYL12B/TCF7L1/TJP1/PTPN6/EGFR/CTNNB1/PTPN1/SORBS1/SMAD4/PTPRJ/SMURF2/RAC2/MYL9/MET/SMAD3/CREBBP	3.33723248962301
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	23/944	122/9376	1.87246457349264	CSH1/CSH2/KRAS/CREB5/PLCG2/JUNB/GH2/IRS2/BCAR1/SOCS2/GNA11/SOCS1/ITPR2/PIK3CA/STAT1/ADCY7/SOS1/STAT5A/MAP2K3/CREB3/SOS2/CREBBP/STAT3	3.2454080240492
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	28/944	160/9376	1.73813559322034	HLA-DRA/HLA-DRB1/HLA-B/HLA-DPA1/HLA-DPB1/HLA-A/HLA-DQB1/ITGB2/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DQA2/HLA-F/ALCAM/CD4/PTPRC/ICAM1/CD86/ESAM/VTCN1/CD99/CLDN23/ITGAM/SDC2/HLA-DRB5/CD58/PDCD1LG2/CADM1	3.15087549343065
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	22/944	116/9376	1.88369374634717	ITGB2/MYL12A/MMP9/NCF2/CXCR4/VAV3/MYL12B/PLCG2/ICAM1/CYBB/ESAM/CD99/SIPA1/CLDN23/ITGAM/BCAR1/CTNNB1/NCF4/PIK3CA/RAC2/MYL9/VAV2	3.20428856034968
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	25/944	138/9376	1.79931220830263	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/ATP6V0E1/MT-CO3/UQCRB/ATP6V0D1/ATP6V1E1/ATP6V1D/MT-ATP8/ATP6V1H/UQCRQ/ATP6V1G1/NDUFAB1/ATP6V1B1/ATP6V1C1/UQCRC2	3.16499732198283
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	38/944	238/9376	1.58581398661159	IGF2/GNG5/FOXO4/KRAS/MRAS/PDGFA/PLCG2/RRAS/RALGDS/EFNA5/RASAL2/EFNA1/PLD1/FGF1/ETS2/EGFR/PDGFB/CSF1R/RASA1/BCL2L1/RAB5A/RASGRF2/EXOC2/PIK3CA/FGFR2/FLT1/RAC2/SHOC2/VEGFA/SOS1/FGF2/RALGAPA2/CALM2/ANGPT2/MET/RASA2/SOS2/NTF4	3.06287289499276
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/944	75/9376	2.11887005649718	CDKN2A/GSTA3/CDKN1A/GSTT1/PMAIP1/BBC3/BIRC3/MAP3K5/FADD/BCL2L1/PDPK1/PIK3CA/GSTM3/BAX/CASP9/MDM2	3.25500602828924
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	32/944	193/9376	1.64679019935014	CXCL2/CCL3/CXCL3/NFKBIA/CXCL16/CXCR6/CCL20/CCL18/GNG5/CXCR4/VAV3/KRAS/CXCL10/CXCL9/CCL4/PLCG2/CCL5/BCAR1/FGR/PIK3CA/STAT1/ADCY7/RAC2/ARRB1/SOS1/CCL2/PREX1/ARRB2/CCL28/VAV2/SOS2/STAT3	3.03777867657648
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	33/944	201/9376	1.63066025803187	HPGD/NUPR1/CDKN1A/BCL2A1/GADD45B/MMP9/SPI1/CD14/PLAU/PDGFA/CD86/FCGR1A/BIRC3/RUNX1/CSF1R/ITGAM/SPINT1/MITF/BCL2L1/NR4A3/FLT1/GADD45G/CEBPA/GADD45A/MET/BCL6/DDB2/JMJD1C/BAX/FUT8/ASPSCR1/MDM2/ETV7	3.02410448880474
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	16/944	76/9376	2.09099018733274	OLR1/CYP27A1/LPL/CD36/SCP2/ACSL3/SCD5/DBI/CPT2/ACADL/SORBS1/FABP3/SLC27A1/PDPK1/GK/ACOX1	3.19515920589453
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	24/944	133/9376	1.79227730342806	TYROBP/HLA-B/FCER1G/HLA-A/ITGB2/FCGR3A/TNFSF10/VAV3/KRAS/CD48/PLCG2/HCST/ICAM1/NFATC2/PTPN6/LCP2/SYK/IFNGR1/TNF/PIK3CA/RAC2/SOS1/VAV2/SOS2	3.07895183490073
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/944	163/9376	1.70614536757825	CDKN1A/TGFBR1/NFKBIA/MMP9/KRAS/CREB5/NFATC2/TLR3/IFIH1/FADD/TNF/STAT6/SMAD4/PIK3CA/TRAF3/STAT1/SOS1/STAT5A/MAP2K3/DDB2/CREB3/BAX/SOS2/SMAD3/CREBBP/RB1/CASP9/STAT3	3.04294230051045
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	26/944	150/9376	1.72158192090395	CDKN1A/TGFBR1/GADD45B/WNT6/KRAS/WNT10A/TCF7L1/FGF1/EGFR/CDKN2B/WNT11/CTNNB1/FZD5/SMAD4/PIK3CA/FGFR2/GADD45G/SOS1/FGF2/GADD45A/MET/DDB2/BAX/SOS2/SMAD3/RB1	2.98078659387706
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/944	268/9376	1.51947887680243	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/DUSP1/MT-CO3/NFE2L2/UQCRB/PINK1/TXN/MT-ATP8/GPR37/SOD1/PSMD7/UBE2L6/UQCRQ/MAP3K5/BCL2L1/PSMB2/UBA7/SLC39A13/UBB/NDUFAB1/ITPR2/TUBB2A/TUBA1A/CALM2/UQCRC2/SLC39A8/UBE2J1/SLC25A5/SLC11A2/BAX/CASP9	2.88688919671124
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	16/944	78/9376	2.03737505432421	C1QB/C1QA/ITGB2/IL1B/SERPING1/LY96/C1QC/CD14/IRF1/CASP1/IL1A/IRF8/ITGAM/TNF/C2/CALM2	3.07818464308555
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/944	33/9376	2.70878274268105	VAMP8/STX4/STX7/SNAP23/STX11/STX3/VAMP7/VAMP2/VAMP5	3.29008396288221
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	33/944	205/9376	1.59884249689955	GSN/HLA-B/CDKN2A/HLA-A/CDKN1A/PMAIP1/NFKBIA/SCIN/SP100/ATP6V0D1/KRAS/HLA-F/CREB5/GTF2A2/TRADD/SND1/IL6ST/CDKN2B/SYK/PIK3CA/TRAF3/STAT5A/NFKB2/CREB3/CDK6/RASA2/HDAC7/BAX/CREBBP/RB1/MDM2/STAT3/RBL2	2.90059793012794
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	16/944	79/9376	2.01158549667453	ATP6V0E1/CLTB/ATP6V0D1/ATP6V1E1/CLTA/ATP6V1D/STX3/ATP6V1H/SLC6A2/VAMP2/ATP6V1G1/SLC1A3/ATP6V1B1/ATP6V1C1/SYT1/SLC1A6	3.02100233341329
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	28/944	168/9376	1.65536723163842	FTL/SQSTM1/FTH1/IL1B/TNFSF10/GLUL/CHMP5/CAPN2/TRADD/CYBB/CASP1/BIRC3/CHMP1B/IL1A/TLR3/IFNGR1/FADD/TNF/STAT6/CHMP1A/STAT1/STAT5A/SMPD1/CHMP4C/SLC25A5/CFLAR/BAX/STAT3	2.86789366627505
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	52/944	362/9376	1.42672534881543	SPP1/CSH1/FN1/CSH2/IGF2/CDKN1A/ITGB6/LAMB4/PPP2R2B/GNG5/ITGA2/KRAS/EREG/PDGFA/CREB5/EFNA5/ITGA3/OSM/EFNA1/FGF1/ITGB4/EGFR/PDGFB/GH2/CSF1R/PIK3AP1/SYK/BCL2L1/CSF3R/OSMR/LAMB3/IL4R/PDPK1/PIK3CA/FGFR2/LAMC2/FLT1/PHLPP2/VEGFA/SOS1/FGF2/ANGPT2/MET/CREB3/CDK6/LAMB2/SOS2/CASP9/MDM2/PPP2CB/RBL2/NTF4	2.77044981050921
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	16/944	80/9376	1.9864406779661	KRAS/PDGFA/PLCG2/EGFR/PDGFB/AXL/BCL2L1/PIK3CA/FGFR2/VEGFA/SOS1/FGF2/MET/BAX/SOS2/STAT3	2.96465557380559
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/944	41/9376	2.42248863166598	CDKN2A/CDKN1A/MMP9/KRAS/EGFR/HBEGF/VEGFA/DAPK1/RB1/MDM2	3.05414679970855
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/944	103/9376	1.83215402336679	SERPINE1/CCL3/C1QB/C1QA/TGFBR1/NFKBIA/IL1B/PPP2R2B/C1QC/CCL5/BDKRB2/IFNGR1/FADD/TNF/GNA11/PIK3CA/CCL2/CFLAR/PPP2CB	2.84130945257414
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	17/944	91/9376	1.85546656733097	NFKBIA/DAPP1/VAV3/KRAS/LILRB4/PLCG2/NFATC2/PTPN6/PIK3AP1/SYK/BTK/INPPL1/PIK3CA/RAC2/SOS1/VAV2/SOS2	2.74371577338199
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	6/944	19/9376	3.13648528099911	HEXB/IDS/HEXA/GNS/NAGLU/HGSNAT	3.11899535017936
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/944	99/9376	1.80585516178737	CDKN2A/CDKN1A/MMP9/KRAS/EGFR/HBEGF/NOTCH3/NOTCH2/JAG1/PIK3CA/ADCY7/SOS1/NCOA3/NOTCH1/BAX/SOS2/RB1/MDM2	2.69697640821808
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/944	37/9376	2.41594136509391	CDKN1A/GADD45B/KRAS/TCF7L1/CTNNB1/GADD45G/GADD45A/DDB2/BAX	2.88736893820315
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	35/944	233/9376	1.49196188259257	FN1/VIM/PDLIM1/FBN1/ITGB6/FMNL2/TNNC1/ITGA2/ZYX/ITGA3/TNNT3/ITGB4/CSRP2/MYH10/ACTG2/PDLIM3/BGN/SDC2/ACTA1/FMNL1/PDLIM5/DIAPH2/PLEC/DAAM1/AGRN/FBLN1/LMNA/NEBL/LMOD1/MYL9/ATP1B1/TMEM43/SUN1/FHL2/SYNE1	2.54431800824261
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/944	51/9376	2.14223994682619	ATP6V0E1/ATP6V0D1/ATP6V1E1/ATP6V1D/PLCG2/TJP1/ATP6V1H/ATP6V1G1/ATP6V1B1/ATP6V1C1/TJP2	2.73668208134413
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/944	32/9376	2.48305084745763	PMAIP1/BIRC7/BBC3/BIRC3/FADD/BCL2L1/BAX/CASP9	2.81171276177599
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/944	52/9376	2.10104302477184	APOE/APOC1/CYP27A1/LPL/LIPA/ABCA1/CD36/LRPAP1/MYLIP/LCAT/NPC1	2.66385858402644
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	19/944	110/9376	1.715562403698	TGFBR1/FBN1/HAMP/SKIL/EMP3/E2F4/NOG/TGIF1/CDKN2B/SMAD7/TNF/SMAD4/INHBA/BMPR2/SMURF2/SKP1/SMAD3/CREBBP/PPP2CB	2.525829582088
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	31/944	205/9376	1.50194295163291	MT-ND2/CTSD/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/TGFBR1/MT-CO3/MMP9/UQCRB/NCF2/PDK4/CD36/MT-ATP8/CYBB/UQCRQ/CPT2/NCF4/NDUFAB1/PIK3CA/RAC2/UQCRC2/SLC25A5/MPC1/SMAD3	2.43124810628286
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	63/944	480/9376	1.30360169491525	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/SQSTM1/MT-CO3/IL1B/UQCRB/OPTN/WIPI1/PINK1/WNT6/KRAS/MAP1LC3B/MT-ATP8/GPR37/CAPN2/WNT10A/CYBB/SOD1/PSMD7/IL1A/UBE2L6/ATXN1/UQCRQ/WNT11/MAP3K5/FADD/PRNP/CTNNB1/TNF/BCL2L1/CAT/PSMB2/UBA7/ULK1/RAB5A/UBB/PTGS2/NDUFAB1/ITPR2/FZD5/TUBB2A/C9orf72/TUBA1A/RAB1A/NOX4/CALM2/UQCRC2/MAP2K3/FIG4/TNFRSF1B/UBE2J1/SLC25A5/BAX/CASP9	2.28472408396651
Human Diseases	Infectious disease: viral	hsa05162	Measles	22/944	136/9376	1.60667996011964	NFKBIA/IL1B/RAB9A/BBC3/TRADD/HSPA6/IL1A/IFIH1/FADD/BCL2L1/HSPA1A/MX2/PIK3CA/TRAF3/STAT1/OAS2/STAT5A/CDK6/BAX/CASP9/STAT3/EIF3H	2.38451168255528
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/944	28/9376	2.48305084745763	ATP6V0E1/ATP6V0D1/ATP6V1E1/ATP6V1D/ATP6V1G1/ATP6V1B1/ATP6V1C1	2.629553683816
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	52/944	388/9376	1.33112004193605	APOE/MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/IL1B/UQCRB/WIPI1/LPL/WNT6/KRAS/MT-ATP8/CAPN2/WNT10A/CYBB/PSMD7/IL1A/IRS2/UQCRQ/WNT11/MAP3K5/FADD/CTNNB1/TNF/PSMB2/RTN4/ULK1/SLC39A13/PTGS2/NDUFAB1/ITPR2/FZD5/PSENEN/PIK3CA/TUBB2A/TUBA1A/NOX4/CALM2/UQCRC2/SLC39A8/SLC25A5/MME/SLC11A2/CASP9	2.2288258482668
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	34/944	235/9376	1.43699963937973	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MGLL/MT-CO3/UQCRB/PRKAB2/KRAS/NPPB/MT-ATP8/CREB5/ACSL3/UQCRQ/CPT2/PRKAG2/MAP3K5/PNPLA2/NDUFAB1/ADCY7/SOS1/FRS2/UQCRC2/MAP2K3/CREB3/SOS2/COX14	2.26999286256021
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	22/944	138/9376	1.58339474330631	FN1/NFKBIA/IL1B/ARPC2/BAIAP2/VAV3/PIP5K1B/IL18/CD4/FCGR2A/CASP1/NFATC2/LCP2/BCAR1/TNF/PIK3CA/RAC2/CCL2/ARPC5/MAP2K3/ARPC1B/VAV2	2.31003953279325
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	31/944	212/9376	1.45235049568276	ITGB2/VAV3/KRAS/MRAS/PDGFA/RRAS/RALGDS/EFNA5/EFNA1/LCP2/FGF1/EGFR/PDGFB/SIPA1/CSF1R/ITGAM/BCAR1/CTNNB1/FPR1/PIK3CA/FGFR2/FLT1/ADCY7/RAC2/VEGFA/FGF2/CALM2/ANGPT2/MAP2K3/MET/VAV2	2.22898321018949
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/944	63/9376	1.89184826472962	CDKN1A/GADD45B/WNT6/WNT10A/TCF7L1/WNT11/CTNNB1/FZD5/GADD45G/GADD45A/DDB2/BAX	2.37641771579459
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/944	109/9376	1.64018037630229	SPP1/CCL3/NFKBIA/IL1B/LY96/CD14/CXCL10/CXCL9/CCL4/CD86/CCL5/TLR3/FADD/TNF/PIK3CA/TRAF3/STAT1/MAP2K3	2.24932578242879
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	31/944	214/9376	1.43877712656423	HLA-B/HLA-A/NFKBIA/GNG5/CXCR4/KRAS/HLA-F/TAPBPL/CD4/PLCG2/TRADD/NFATC2/SAMHD1/FADD/TNF/BCL2L1/GNA11/ITPR2/APOBEC3C/PIK3CA/AP1S2/LIMK2/BST2/TAPBP/RAC2/SKP1/CALM2/MAP2K3/TNFRSF1B/BAX/CASP9	2.17251137533844
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	20/944	125/9376	1.58915254237288	CTSD/FCER1G/ASAH1/PPP2R2B/KRAS/TRADD/PLD1/BDKRB2/MAP3K5/TNF/SGMS2/ORMDL1/PDPK1/PIK3CA/RAC2/ORMDL3/SMPD1/BAX/PPP2CB/CERS2	2.21868046017718
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	24/944	157/9376	1.51829860736263	SERPINE1/ITGB2/TGFBR1/PPP2R2B/RASSF6/WNT6/WNT10A/BBC3/TCF7L1/BIRC3/AMOT/FGF1/WNT11/SMAD7/CTNNB1/FZD5/SMAD4/AJUBA/BMPR2/LATS2/WWC1/LLGL2/SMAD3/PPP2CB	2.19126194760396
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/944	94/9376	1.69058781103498	CXCL2/CXCL3/NFKBIA/IL1B/MMP9/CCL20/S100A8/CXCL10/JUND/TRADD/FADD/TNF/PTGS2/TRAF3/S100A9/CCL2	2.25148153681973
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/944	103/9376	1.63929570511766	FN1/CXCL2/ITGB2/CXCL3/LAMB4/IL1B/PRDX1/CD14/HSPB1/ITGAM/TNF/GNA11/RAB5A/LAMB3/PIK3CA/LAMC2/LAMB2	2.18281337220695
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	27/944	184/9376	1.45744288872513	MYL12A/CXCR4/KRAS/NTN4/DPYSL2/MYL12B/SEMA3C/PLCG2/RRAS/EFNA5/NFATC2/EFNA1/PLXNC1/SSH3/ABLIM1/RASA1/PDPK1/PIK3CA/LIMK2/BMPR2/SEMA6D/RAC2/NRP1/MYL9/MET/SSH2/NCK2	2.09675226409851
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	17/944	104/9376	1.6235332464146	LPCAT3/LPIN2/CDIPT/PLD3/PLD1/DGKA/DGKH/GDPD5/SGMS2/CDS1/PLA2G15/MBOAT2/LCAT/PCYT2/LPCAT2/PGS1/GPCPD1	2.13941930009708
NA	NA	hsa04517	IgSF CAM signaling	40/944	299/9376	1.32872286151579	ITGB2/MYL12A/ARPC2/MYL6/BAIAP2/VAV3/CD84/CD48/MYL12B/PLCG2/ICAM1/CD86/TJP1/PTPN6/ESAM/LCP2/ITGAX/MYH10/RASA1/ITGAM/BCAR1/CTNNB1/SORBS1/IL1RAP/DOK2/PDPK1/PIK3CA/TUBB2A/TUBA1A/GLDN/TJP2/ARPC5/NRP1/MYL9/MBP/ARPC1B/VAV2/CADM1/NRP2/NCK2	1.93286121536469
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/944	99/9376	1.60520458825544	KRAS/PIP5K1B/PDGFA/RALGDS/PLD1/EGFR/PDGFB/DGKA/DGKH/PDPK1/PIK3CA/RAC2/SOS1/SOS2/SLC22A5/GPCPD1	2.02545392034224
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/944	115/9376	1.55460574797347	CDKN1A/NR4A2/JUND/CREB5/MAFB/PLD1/EGFR/AKAP13/HBEGF/GNA11/ITPR2/ADCY7/ARRB1/PDE4B/EGR1/CREB3/ARRB2/MEF2A	2.0022148624242
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/944	62/9376	1.76216511755057	PRKAB2/KRAS/SOD1/HSPA6/IRS2/PRKAG2/CAT/HSPA1A/PIK3CA/ADCY7/SOD2	2.01457357316633
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/944	62/9376	1.76216511755057	ATXN1/TLE6/CIR1/NOTCH3/NOTCH2/JAG1/MAML2/PSENEN/DTX3L/NOTCH1/CREBBP	2.01457357316633
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/944	50/9376	1.78779661016949	ITGB2/IL1B/CD36/IL18/ICAM1/SDC2/TNF/CCL2/MET	1.86877812043743
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/944	89/9376	1.56236907255761	SPP1/FN1/ITGB6/LAMB4/CD44/ITGA2/CD36/ITGA3/ITGB4/NPNT/LAMB3/LAMC2/AGRN/LAMB2	1.7835490012099
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	18/944	122/9376	1.46540705751598	RCAN1/KRAS/PLCG2/PLCD3/CTNNB1/NOTCH3/NOTCH2/PDPK1/PIK3CA/MED13L/STAT1/SLC16A2/NCOA3/ATP1B1/NOTCH1/CREBBP/CASP9/MDM2	1.73122880263771
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	15/944	98/9376	1.52023521272916	PIP5K1B/CDIPT/PLCG2/DGKA/DGKH/PLCD3/ITPR2/CDS1/INPPL1/PIK3CA/INPP1/CALM2/OCRL/SYNJ2/PI4K2A	1.73217567204466
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/944	29/9376	2.05493863237873	RASSF6/RASSF4/RASSF2/AJUBA/LATS2/WWC1	1.90369079839046
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/944	90/9376	1.54500941619586	PRKAB2/SESN1/KRAS/CREB5/IRS2/PRKAG2/CAT/ULK1/ADIPOR1/PIK3CA/ADCY7/CREB3/BAX/SOD2	1.73827008895859
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/944	140/9376	1.41888619854722	SPP1/SERPINE1/TGFBR1/PRKAB2/GNG5/KRAS/MAP1LC3B/MRAS/RRAS/PRKAG2/SLC8A1/NOTCH3/ITPR2/JAG1/SMAD4/ADCY7/CALM2/EGR1/SMAD3/MEF2A	1.67079991155588
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/944	149/9376	1.39984074621772	FCER1G/KRAS/PIP5K1B/MRAS/PDGFA/CYTH3/PLCG2/RRAS/RALGDS/PLD1/EGFR/PDGFB/DGKA/DGKH/SYK/PIK3CA/ADCY7/SOS1/CYTH1/CYTH2/SOS2	1.64610016942916
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	22/944	158/9376	1.38296502896374	LPIN2/ATP6V1E1/WNT6/KRAS/ATP6V1D/WNT10A/ATP6V1H/WNT11/TNF/ATP6V1G1/ULK1/WDR59/RRAGD/FZD5/PDPK1/PIK3CA/ATP6V1B1/ATP6V1C1/SOS1/RRAGB/LAMTOR5/SOS2	1.62433516172048
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/944	60/9376	1.65536723163842	KRAS/PLCG2/HSPB1/NFATC2/PTGS2/PIK3CA/RAC2/MAPKAPK3/VEGFA/CASP9	1.7039307659028
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/944	78/9376	1.52803129074316	ISYNA1/PIP5K1B/CDIPT/PLCG2/PLCD3/INPPL1/PIK3CA/INPP1/OCRL/FIG4/SYNJ2/PI4K2A	1.56681790588561
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/944	78/9376	1.52803129074316	FN1/CLTB/ARPC2/ELMO3/CLTA/HCLS1/BCAR1/CTNNB1/PIK3CA/ARPC5/MET/ARPC1B	1.56681790588561
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/944	70/9376	1.56077481840194	NFKBIA/PRKAB2/CD36/TRADD/ACSL3/IRS2/PRKAG2/TNF/ADIPOR1/TNFRSF1B/STAT3	1.57565936743718
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/944	87/9376	1.48412234560686	MT-CYB/COX4I1/MT-CO2/MT-CO1/MT-CO3/UQCRB/TNNC1/CACNA2D3/CACNG4/UQCRQ/SLC8A1/UQCRC2/ATP1B1	1.51787710425221
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/944	32/9376	1.86228813559322	GABARAPL1/GABARAPL2/WIPI1/GABARAP/ATG9B/PPP2CB	1.6348101343469
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/944	55/9376	1.62526964560863	HEXB/ASAH1/PSAP/HEXA/SGMS2/SMPD1/ACER3/ARSA/CERS2	1.55605080674794
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/944	71/9376	1.53879207448078	KRAS/IRF1/CISH/SOCS2/SOCS1/PIK3CA/STAT1/SOS1/STAT5A/SOS2/STAT3	1.52474957422893
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	19/944	139/9376	1.35763931227899	CTSD/MMP9/KRT18/KRAS/KRT14/CREB5/HSPA6/EGFR/KRT23/HBEGF/HSPA1A/ITPR2/PIK3CA/ADCY7/SOS1/CALM2/NCOA3/CREB3/SOS2	1.42132539537389
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/944	122/9376	1.38399555432064	PPP2R2B/PRKAB2/CD36/FBP1/CREB5/SCD5/IRS2/PRKAG2/ULK1/RAB11B/ADIPOR1/PDPK1/PIK3CA/MLYCD/CREB3/PFKFB3/PPP2CB	1.42839295835541
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	17/944	122/9376	1.38399555432064	NFKBIA/PPP2R2B/VAV3/KRAS/CD4/PTPRC/NFATC2/PTPN6/LCP2/TNF/PDPK1/PIK3CA/SOS1/VAV2/SOS2/PPP2CB/NCK2	1.42839295835541
NA	NA	hsa03272	Virion - Hepatitis viruses	8/944	48/9376	1.65536723163842	TSG101/CHMP1B/EGFR/CLDN23/CD9/CHMP1A/IST1/LAMP2	1.52306139166125
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	21/944	157/9376	1.3285112814423	C1QB/C1QA/DUSP2/C1QC/LIPA/P2RY6/ABCA1/CD36/HAVCR2/ALOX5/CASP1/NFATC2/PTPN6/PTGER4/AXL/BCAR1/GULP1/TMEM30A/RAB5A/PTGS2/PLA2G15	1.38887942232011
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	21/944	157/9376	1.3285112814423	MT-CYB/COX4I1/MT-CO2/MT-CO1/MT-CO3/IL1B/UQCRB/PRKAB2/IL1A/IRS2/UQCRQ/PRKAG2/MAP3K5/TNF/NDUFAB1/ADIPOR1/PIK3CA/CEBPA/UQCRC2/MLXIP/BAX	1.38887942232011
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	38/944	308/9376	1.22540171692714	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/MT-CO3/CLTB/UQCRB/WIPI1/CLTA/MT-ATP8/CREB5/BBC3/SOD1/PSMD7/UQCRQ/MAP3K5/PSMB2/ULK1/RCOR1/NDUFAB1/SLC1A3/TUBB2A/TUBA1A/UQCRC2/POLR2C/CREB3/SLC25A5/BAX/SOD2/CREBBP/CASP9	1.34580816478145
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/944	89/9376	1.45077128166064	ADRB1/KRAS/PDGFA/TJP1/EGFR/PDGFB/GNA11/ITPR2/TUBB2A/ADCY7/TUBA1A/SOS1/SOS2	1.42961750283232
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/944	73/9376	1.49663338750871	TSG101/CXCR4/ELL/CD4/SAMHD1/FEZ1/APOBEC3C/MX2/BST2/ELL2/CREBBP	1.42525367271741
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/944	57/9376	1.56824264049955	ACADVL/HADHB/SCP2/ACSL3/SCD5/CPT2/ACADL/ACOX1/PPT1	1.43976936364657
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/944	90/9376	1.4346516007533	NFKBIA/KRAS/CD4/NFATC2/PTPN6/EGFR/IFNGR1/PIK3CA/EML4/STAT1/BATF3/MAP2K3/STAT3	1.38629141856131
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/944	34/9376	1.75274177467597	PRKAB2/DBP/PRKAG2/BHLHE40/SKP1/PER3	1.47120056178909
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	19/944	143/9376	1.31966338746	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/C1QB/C1QA/HLA-DQB1/HLA-DMA/HLA-DQA1/FCGR3A/HLA-DMB/HLA-DQA2/C1QC/CD86/FCGR2A/FCGR1A/TNF/C2/HLA-DRB5	1.28883058801865
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/944	109/9376	1.36681698025191	NFKBIA/PRKAB2/CD36/CREB5/PPP1R3D/IRS2/PRKAG2/TNF/PTPN1/SLC27A1/PDPK1/PIK3CA/CREB3/MLXIP/STAT3	1.28884127295349
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/944	144/9376	1.31049905838041	DUSP9/ISL1/WNT6/SKIL/KRAS/KLF4/WNT10A/IL6ST/WNT11/CTNNB1/FZD5/SMAD4/PIK3CA/FGFR2/INHBA/BMPR2/FGF2/SMAD3/STAT3	1.25631912766845
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/944	43/9376	1.61687031927473	ACADVL/ECI1/HADHB/ACSL3/CPT2/ACADL/ACOX1	1.35651251841426
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/944	110/9376	1.35439137134052	SERPINE1/CDKN1A/HMOX1/PLCG2/CYBB/EGFR/IFNGR1/PIK3CA/FLT1/VEGFA/EPAS1/ANGPT2/PFKFB3/CREBBP/STAT3	1.25094919009526
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/944	85/9376	1.40219341974078	TK2/NME4/GMPR/NME3/UPP1/LACC1/RRM2B/PNP/DCTPP1/CDA/DGUOK/AK9	1.24629120456038
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/944	155/9376	1.28157463094587	CDKN2A/CDKN1A/WNT6/CREB5/WNT10A/TCF7L1/CRH/EGFR/CDKN2B/WNT11/CTNNB1/GNA11/AHR/ITPR2/FZD5/HSD3B1/ADCY7/CREB3/CDK6/RB1	1.1827057222588
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/944	36/9376	1.65536723163842	GALNT18/GALNT11/GALNT7/ST6GALNAC2/B3GNT3/GALNT6	1.31816225469298
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/944	44/9376	1.58012326656394	STX4/ARHGDIB/CREB5/VAMP2/RAB5A/RAB11B/CREB3	1.29052253729429
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/944	61/9376	1.46540705751598	SLC40A1/FTL/MT2A/FTH1/HMOX1/SLC8A1/CYBRD1/ATP1B1/SLC11A2	1.22014877721927
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/944	70/9376	1.41888619854722	CDKN1A/KRAS/PDGFB/PIK3CA/VEGFA/SOS1/EPAS1/MET/SOS2/CREBBP	1.17698216997682
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/944	54/9376	1.47143753923415	CDO1/SMS/SDS/BCAT1/IL4I1/SDSL/LACC1/BCAT2	1.1624461092511
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	38/944	323/9376	1.16849451645065	TIMP3/VIM/CDKN2A/CDKN1A/MARCKS/MMP9/CD44/UBE2I/HMOX1/PIM1/KRAS/PDCD4/PLAU/PDGFA/ZEB2/PLCG2/EFNA5/EFNA1/FOXP1/EGFR/PDGFB/IRS2/NOTCH3/PTGS2/SOCS1/NOTCH2/PIK3CA/TP63/BMPR2/VEGFA/SOS1/MET/CDK6/NOTCH1/SOS2/CREBBP/MDM2/STAT3	1.03109126805781
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/944	38/9376	1.56824264049955	QPRT/BST1/NMRK1/SIRT2/PNP/SIRT5	1.1743701927218
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/944	142/9376	1.25901169730246	BIRC7/NEDD4L/UBE2I/BIRC3/UBE2L6/UBE2Q1/UBA7/UBB/SOCS1/SMURF2/SKP1/UBE2H/NEDD4/DDB2/UBE2J1/PIAS1/UBE2E1/MDM2	1.04057874650535
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/944	15/9376	1.9864406779661	HEXB/HEXA/B3GALT4	1.2792688244242
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/944	217/9376	1.19003358587831	GSTA3/GSTT1/ADRB1/KRAS/KLF4/CREB5/EPHX2/EGFR/AHR/NOTCH2/JAG1/PIK3CA/GSTM3/ADCY7/VEGFA/ARRB1/SOS1/FGF2/STAT5A/KLF5/BCL6/CREB3/ARRB2/SOS2/RB1/STAT3	0.947638152285948
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/944	83/9376	1.31631611190525	NFKBIA/IL1B/IFI16/TREX1/CXCL10/IL18/CCL4/CASP1/CCL5/SAMHD1/FADD	0.968475698771407
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	42/944	368/9376	1.13356669123066	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MT-CYB/MT-ATP6/COX4I1/MT-CO2/MT-CO1/SQSTM1/MT-CO3/UQCRB/OPTN/WIPI1/PINK1/MAP1LC3B/ANXA11/MT-ATP8/SOD1/PSMD7/CASP1/UQCRQ/MAP3K5/TNF/BCL2L1/CAT/PSMB2/ULK1/RAB5A/NDUFAB1/TUBB2A/C9orf72/TUBA1A/RAB1A/UQCRC2/MAP2K3/FIG4/TNFRSF1B/BAX/CASP9	0.874609568963002
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/944	16/9376	1.86228813559322	HEXB/A4GALT/HEXA	1.1549968877052
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/944	93/9376	1.28157463094587	KRAS/PLD1/EGFR/HBEGF/GNA11/ITPR2/ADCY7/SOS1/CALM2/MAP2K3/EGR1/SOS2	0.913055462452197
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/944	138/9376	1.22353230164579	RHOQ/PRKAB2/KRAS/FBP1/PPP1R3D/IRS2/PRKAG2/PTPN1/SOCS2/SORBS1/SOCS1/INPPL1/PDPK1/PIK3CA/SOS1/CALM2/SOS2	0.885109884143939
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	19/944	158/9376	1.1943788886505	CDKN2A/CDKN1A/TFDP2/GADD45B/CDKN1C/E2F4/CDKN2B/SMC1B/SMAD4/SKP1/GADD45G/GADD45A/CDK6/SMAD3/CREBBP/RB1/MDM2/PPP2CB/RBL2	0.824452468637957
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/944	59/9376	1.34673944268888	TK2/NME4/NME3/UPP1/RRM2B/DCTPP1/CDA/AK9	0.893917709678455
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/944	17/9376	1.75274177467597	CYP27A1/SCP2/HSD3B7	1.03935065019542
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/944	17/9376	1.75274177467597	MYH10/LAMP2/NRP2	1.03935065019542
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/944	86/9376	1.27039810800158	CDKN1A/KRAS/EREG/PLCG2/EGFR/HBEGF/PIK3CA/SOS1/STAT5A/SOS2/NCK2	0.842852061787856
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/944	18/9376	1.65536723163842	HEXB/HEXA/MAN2B2	0.931184613792169
Organismal Systems	Immune system	hsa04611	Platelet activation	15/944	126/9376	1.18240516545601	VAMP8/FCER1G/MYL12A/ITGA2/MYL12B/FERMT3/PLCG2/SNAP23/FCGR2A/LCP2/SYK/BTK/ITPR2/PIK3CA/ADCY7	0.689696267017144
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/944	27/9376	1.47143753923415	SCP2/SCD5/ACOX1/ACOT2	0.820785734765828
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/944	99/9376	1.20390344119158	ITGB6/PRKAB2/TNNC1/ITGA2/ITGA3/ITGB4/CACNA2D3/CACNG4/PRKAG2/TNF/SLC8A1/LMNA	0.682408944590554
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/944	82/9376	1.21124431583299	GSTA3/GSTT1/TK2/NME4/NME3/UPP1/GSTM3/RRM2B/CDA/CES2	0.642831219383758
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	19/944	166/9376	1.1368184602818	RGS2/ADRB1/NPPB/CREB5/NFATC2/CNGB1/BDKRB2/IRS2/SLC8A1/GNA11/ITPR2/ADCY7/CALM2/MYL9/GTF2I/CREB3/ATP1B1/SLC25A5/MEF2A	0.595079876241742
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/944	37/9376	1.34218964727439	IL1B/APOL1/IL18/ICAM1/TNF	0.697788611076595
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/944	101/9376	1.18006376908877	WNT6/KRAS/WNT10A/TCF7L1/WNT11/MITF/CTNNB1/FZD5/ADCY7/CALM2/CREB3/CREBBP	0.608746392712417
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/944	20/9376	1.48983050847458	CYB5R1/NPL/CMAS	0.733705980047174
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/944	130/9376	1.14602346805737	TGFBR1/NFKBIA/MMP9/GNG5/KRAS/CREB5/EGFR/PIK3CA/ADCY7/VEGFA/ARRB1/SOS1/CREB3/ARRB2/SOS2	0.560949450254792
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/944	65/9376	1.22242503259452	MGLL/LPIN2/LPL/DGKA/DGKH/PNPLA2/MBOAT2/GK	0.602072116375376
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/944	65/9376	1.22242503259452	SPP1/KISS1/KRAS/GNA11/ITPR2/PIK3CA/ARRB1/ARRB2	0.602072116375376
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/944	38/9376	1.30686886708296	NEDD4L/KRAS/PDPK1/PIK3CA/ATP1B1	0.634196775975354
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/944	48/9376	1.24152542372881	BCAT1/HADHB/IL4I1/AUH/BCAT2/MCEE	0.561300642185503
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/944	21/9376	1.41888619854722	BCAT1/BCAT2/PPCS	0.642969155316337
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/944	30/9376	1.32429378531073	IL1B/FOLR1/TNF/FOLR2	0.595240813380751
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/944	86/9376	1.15490737091052	ITGB6/ITGA2/ITGA3/TCF7L1/ITGB4/CACNA2D3/CACNG4/CTNNB1/SLC8A1/LMNA	0.482858396913451
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/944	105/9376	1.13510895883777	ITGB6/ADRB1/TNNC1/ITGA2/ITGA3/ITGB4/CACNA2D3/CACNG4/TNF/SLC8A1/ADCY7/LMNA	0.465823981088885
NA	NA	hsa04519	Cadherin signaling	43/944	404/9376	1.05714045980869	VIM/KRT7/KRT8/NFKBIA/CDH8/ARPC2/KRT18/WNT6/VAV3/KRAS/MRAS/KRT14/WNT10A/RRAS/TCF7L1/TMC4/AMOTL2/TJP1/ANKRD6/EGFR/LHFPL2/NCKAP1L/KRT23/WNT11/CTNNB1/FZD5/PSENEN/AJUBA/RAC2/SHOC2/DAAM1/LATS2/ARPC5/TMC5/MAP2K3/MET/WWC1/ARPC1B/MYO1D/VAV2/CREBBP/TMC1/AMOTL1	0.392822284807124
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/944	31/9376	1.28157463094587	ACSS1/GLUL/CAT/MCEE	0.525401192345581
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/944	154/9376	1.09641206251376	CDKN1A/RGS2/PRKAB2/MYL6/RCAN1/KRAS/NFATC2/PPP1R12B/EGFR/CACNA2D3/CACNG4/PRKAG2/PTGS2/ITPR2/ADCY7/CALM2/MYL9	0.403631927251596
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/944	59/9376	1.17839701235277	GSTA3/GSTT1/GPX4/SMS/GSTM3/RRM2B/GSTK1	0.459919550712776
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/944	59/9376	1.17839701235277	MGLL/ADRB1/IRS2/PNPLA2/PTGS2/PIK3CA/ADCY7	0.459919550712776
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/944	32/9376	1.24152542372881	ACSS1/MLYCD/ACOX1/MCEE	0.457907506917805
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/944	195/9376	1.06962190352021	ITGB2/FCGR3A/CASP4/NCF2/C5AR1/FPR3/PLCG2/CYBB/FCGR2A/FCGR1A/CASP1/AQP9/SYK/ITGAM/NCF4/FPR1/PIK3CA/RAC2/CLEC7A/SLC25A5/HDAC7	0.328718798963644
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/944	52/9376	1.14602346805737	HSD17B1/ALOX5/PTGS2/HSD3B1/ADCY7/ACOT2	0.353288527425649
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/944	120/9376	1.07598870056497	NFKBIA/ARHGDIB/KRAS/PLCG2/MAP3K5/PDPK1/PIK3CA/SOS1/FRS2/CALM2/BAX/SOS2/NTF4	0.28030723305015
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/944	72/9376	1.10357815442561	NFKBIA/CXCL10/TRADD/IFIH1/FADD/TNF/DHX58/TRAF3	0.295192896320825
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/944	174/9376	1.02746931618936	MAN1A1/NFE2L2/CAPN2/HSPA6/AMFR/MAP3K5/BCAP31/DNAJB2/HSPA1A/MBTPS1/SKP1/NSFL1C/HSPA4L/WFS1/UBE2J1/SIL1/BAX/DNAJB1	0.122373588204527
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/944	194/9376	1.02393849379696	DYNLRB1/MYL12A/DYNLT1/MYL6/TNNC1/MYL12B/KIFC3/TNNT3/MYH10/ACTG2/DYNLRB2/MYO5B/ACTA1/TUBB2A/TUBA1A/MYL9/MYO1D/KIF13A/KIF13B/MYO6	0.11272892834561
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	26/944	254/9376	1.0166822367543	ADRB1/CXCR4/TNNC1/PDGFA/PLCG2/NFATC2/FGF1/EGFR/PDGFB/BDKRB2/ORAI3/TPCN1/PLCD3/SLC8A1/GNA11/ITPR2/FGFR2/FLT1/ADCY7/VEGFA/FGF2/STIM2/CALM2/MET/SLC25A5/MCOLN1	0.0901846120044832
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/944	46/9376	1.07958732498158	PSMB10/PSMB9/PSMD7/PSMB8/PSMB2	0.181045751618386
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/944	47/9376	1.05661738189686	ACSS1/ACYP2/LDHD/HAGH/ME2	0.130192960200318
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/944	47/9376	1.05661738189686	IRS2/TNF/SOCS2/SOCS1/PIK3CA	0.130192960200318
NA	NA	hsa04382	Cornified envelope formation	22/944	217/9376	1.00695149574319	S100A10/KRT7/S100A11/S100A6/KRT8/COL17A1/DST/PPP2R2B/KRT18/S100A8/KRT14/EPHX2/TJP1/ITGB4/KRT23/CLDN23/LAMB3/SLC27A1/LAMC2/S100A9/PLEC/PPP2CB	0.0346649385751951
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/944	17/9376	1.16849451645065	CDO1/FMO4	0.232649350838444
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/944	178/9376	1.00438011807275	WNT6/WNT10A/TCF7L1/MMP7/ANKRD6/NFATC2/CBY1/WNT11/TLE6/SERPINF1/CTNNB1/FZD5/SMAD4/RAC2/DAAM1/SKP1/SMAD3/CREBBP	0.0197403774613416
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/944	128/9376	1.00873940677966	NME4/PDE7A/GMPR/NME3/LACC1/PDE10A/ADCY7/FHIT/RRM2B/PNP/PDE4B/DGUOK/AK9	0.0333095959715651
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/944	98/9376	1.01349014181944	NR4A2/CREB5/GNA11/ITPR2/HSD3B1/ADCY7/CALM2/CREB3/ATP1B1/DAGLB	0.0449167893681795
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/944	78/9376	1.0186875271621	BTG3/LSM1/BTG2/CNOT6L/BTG1/DCP1B/XRN1/PARN	0.0554511686856635
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/944	99/9376	1.00325286765965	IL1B/PLCG2/PTGER4/BDKRB2/IL1RAP/ITPR2/PIK3CA/ADCY7/CALM2/MAP2K3	0.0108864567147107
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/944	28/9376	1.06416464891041	HADHB/ACOT2/PPT1	0.113768445095712
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/944	51/9376	0.97374543037554	PLA2G7/PLD3/PLD1/GDPD3/LPCAT2	-0.0629030795537348
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/944	30/9376	0.993220338983051	PIGC/B3GALT4/PGAP3	-0.0124440588163222
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/944	93/9376	0.961180973209404	LYZ/ADRB1/VAMP2/BST1/ITPR2/ADCY7/CALM2/SLC4A2/ATP1B1	-0.125877549192439
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/944	83/9376	0.957320808658362	LCOR/L3MBTL3/SKP1/PHC2/SCML1/PHF1/CREBBP/YAF2	-0.130672318297756
NA	NA	hsa04981	Folate transport and metabolism	3/944	31/9376	0.961180973209404	FOLR1/SLCO2B1/FOLR2	-0.0724339507893907
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/944	63/9376	0.94592413236481	HPGD/GPX4/EPHX2/ALOX5/PTGS2/PTGES	-0.144090485935056
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/944	63/9376	0.94592413236481	ERCC4/POLD4/XPC/POLR2C/DDB2/CETN2	-0.144090485935056
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/944	53/9376	0.937000319795331	CLTB/CLTA/BDKRB2/SLC8A1/ATP1B1	-0.153888006601215
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/944	21/9376	0.94592413236481	DSE/CHST11	-0.0830037252527833
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/944	65/9376	0.916818774445893	CREB5/GNA11/ITPR2/HSD3B1/ADCY7/CREB3	-0.225159443286923
Genetic Information Processing	Translation	hsa03010	Ribosome	21/944	222/9376	0.939532753092075	RPS15A/RPL34/RPS14/RPS4Y1/RPS29/FAU/RPL23/RPS25/RPS28/RPS20/RPL36A/RPL31/RPS27/RPL37/RPS12/RPS21/RPL10A/RPL30/RPLP2/RPL38/MRPL46	-0.305068639384196
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/944	10/9376	0.993220338983051	ETHE1	-0.00717690569111553
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/944	44/9376	0.902927580893683	HEXB/MAN1A1/HEXA/FUT8	-0.215944010224543
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/944	22/9376	0.902927580893683	AOC1/HNMT	-0.15251580336591
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/944	226/9376	0.92290385480726	NFKBIA/ADRB1/VAV3/CREB5/RRAS/CNGB1/CRH/PLD1/PDE10A/PIK3CA/ADCY7/RAC2/CALM2/PDE4B/MYL9/HCAR2/CREB3/ATP1B1/ACOX1/VAV2/CREBBP	-0.392538874418347
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/944	23/9376	0.863669859985262	GLUL/ASS1	-0.219021459165766
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/944	23/9376	0.863669859985262	CTSA/MME	-0.219021459165766
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/944	46/9376	0.863669859985262	FTL/FTH1/HMOX1/BLVRA	-0.310124667124087
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/944	70/9376	0.851331719128329	GSTA3/GSTT1/PTGS2/SULT1A1/GSTM3/GSTK1	-0.417726619864607
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/944	12/9376	0.827683615819209	NPC1	-0.199844789689522
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/944	37/9376	0.805313788364636	GLUL/IL4I1/ASS1	-0.397001552486684
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/944	60/9376	0.827683615819209	KRAS/CRH/GNA11/ITPR2/PPP2CB	-0.448016278965821
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/944	49/9376	0.810792113455552	GALNT18/GALNT11/GALNT7/GALNT6	-0.444296224460952
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/944	149/9376	0.866568080991924	MT-ND2/MT-ND4L/MT-ND5/MT-ND1/MT-ND3/MT-ND4/MGLL/GNG5/PTGS2/NDUFAB1/ITPR2/ADCY7/DAGLB	-0.549324466213488
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/944	38/9376	0.784121320249777	HEXB/HEXA/AMDHD2	-0.446150057517545
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/944	38/9376	0.784121320249777	CD4/PTPRC/BTK	-0.446150057517545
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/944	107/9376	0.835418976714716	PRKAB2/FBP1/PPP4C/CREB5/PRKAG2/ITPR2/CALM2/CREB3/CREBBP	-0.572877205732813
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/944	14/9376	0.709443099273608	FUT8	-0.364013281927283
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/944	75/9376	0.794576271186441	SDS/GLUL/BCAT1/SDSL/ASS1/BCAT2	-0.597616739994933
NA	NA	hsa04081	Hormone signaling	19/944	219/9376	0.861698010989861	CSH1/CSH2/SLC40A1/IGF2/HAMP/ADRB1/GNG5/NPPB/CRH/GH2/IRS2/GNA11/ADIPOR1/SMAD4/PIK3CA/ADCY7/STAT5A/SLC16A2/STAT3	-0.692915398655401
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/944	28/9376	0.709443099273608	A4GALT/B3GNT3	-0.515177864584359
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	12/944	144/9376	0.827683615819209	WIPI1/PSMD7/ATXN1/MAP3K5/PSMB2/ULK1/ITPR2/PIK3CA/BEAN1/VLDLR/SLC25A5/SLC1A6	-0.697214254323965
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/944	41/9376	0.726746589499793	SDS/SDSL/BPGM	-0.586687310260783
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/944	134/9376	0.815330129015937	MYL6/NPPB/PPP1R12B/MYH10/ACTG2/GNA11/ITPR2/ADCY7/CALD1/CALM2/MYL9	-0.720396840251788
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/944	29/9376	0.684979544126242	CNGB1/CALM2	-0.568470548660641
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/944	42/9376	0.709443099273608	AOC1/IL4I1/CAT	-0.631434457491082
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/944	16/9376	0.620762711864407	IL4I1	-0.507971604175015
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/944	43/9376	0.692944422546314	ABCA1/CD36/SLC27A1	-0.675222525140389
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/944	91/9376	0.764015645371578	GNG5/PDE7A/PDE10A/ADCY7/ARRB1/PDE4B/ARRB2	-0.756866510967773
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/944	56/9376	0.709443099273608	SPOPL/SMURF2/ARRB1/ARRB2	-0.729665123115116
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/944	44/9376	0.677195685670262	GTF2A2/GTF2I/TAF6	-0.718099526064154
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/944	31/9376	0.640787315472936	FBP1/IDNK	-0.670269093924362
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/944	31/9376	0.640787315472936	MLYCD/ACOX1	-0.670269093924362
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/944	17/9376	0.584247258225324	GLUL	-0.574051948518527
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/944	69/9376	0.719724883321051	CTSB/ADRB1/PTGER4/ITPR2/CALM2	-0.78182682424461
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	9/944	116/9376	0.770601987142022	SDS/ACSS1/FBP1/SDSL/CAT/IDNK/ME2/ACOX1/MCEE	-0.831801097842097
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/944	18/9376	0.551789077212806	ACSL3	-0.636844649662461
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/944	18/9376	0.551789077212806	PRDX1	-0.636844649662461
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/944	71/9376	0.69945094294581	KRAS/EGFR/PIK3CA/FGFR2/MET	-0.850535983143208
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/944	33/9376	0.601951720595788	BCAT1/BCAT2	-0.76640068266718
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/944	154/9376	0.773937926480299	PPP2R2B/ADRB1/TNNC1/CREB5/CACNA2D3/CACNG4/SLC8A1/ADCY7/CALM2/CREB3/ATP1B1/PPP2CB	-0.946415500656138
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/944	73/9376	0.680287903413048	GSTA3/GSTT1/GSTM3/FMO4/GSTK1	-0.917519545269691
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/944	86/9376	0.692944422546314	CREB5/VAMP2/GNA11/ADCY7/CREB3/ATP1B1	-0.957116262584168
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/944	20/9376	0.496610169491525	LIPA	-0.754016180186889
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/944	35/9376	0.567554479418886	FBP1/PFKFB3	-0.857580851769625
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/944	75/9376	0.662146892655367	CREB5/ITPR2/ADCY7/CREB3/ATP1B1	-0.98287901682335
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/944	76/9376	0.653434433541481	ITPR2/ADCY7/CALM2/SLC4A2/ATP1B1	-1.01497902820117
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/944	89/9376	0.669586745381832	GABARAPL1/GABARAPL2/GNG5/GLUL/GABARAP/ADCY7	-1.04790298581076
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/944	37/9376	0.536875858909757	IL4I1/FAHD1	-0.944396634268323
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/944	115/9376	0.690935887988209	GNG5/KRAS/CREB5/GNA11/ITPR2/PIK3CA/ADCY7/CREB3	-1.11577054650639
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/944	116/9376	0.684979544126242	GNG5/HOMER3/GLUL/PLD1/ITPR2/SLC1A3/ADCY7/SLC1A6	-1.14226953308762
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/944	23/9376	0.431834929992631	POLD4	-0.912786729820572
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/944	23/9376	0.431834929992631	ATP1B1	-0.912786729820572
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/944	67/9376	0.592967366557045	KRAS/ITPR2/CALM2/CREBBP	-1.11872012902142
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/944	54/9376	0.551789077212806	RMI2/ERCC4/SLX1A	-1.10517512916816
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/944	41/9376	0.484497726333196	POLD4/UIMC1	-1.10680646882783
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/944	133/9376	0.672103988785523	PPP2R2B/GNG5/CREB5/ITPR2/ARRB1/CALM2/CREB3/ARRB2/PPP2CB	-1.27427104249631
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/944	26/9376	0.382007822685789	ACOX1	-1.05577210390617
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/944	26/9376	0.382007822685789	SLC52A3	-1.05577210390617
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/944	28/9376	0.354721549636804	MOCS2	-1.14412417426443
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/944	45/9376	0.441431261770245	ABCG1/ABCA1	-1.25668121774415
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/944	102/9376	0.584247258225324	RAB27B/BST1/ITPR2/ADCY7/SLC4A2/ATP1B1	-1.41256355978617
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/944	48/9376	0.413841807909604	PIK3CA/ATP1B1	-1.36222085676599
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/944	31/9376	0.320393657736468	IMMP2L	-1.26810423705933
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/944	79/9376	0.502896374168633	GSTA3/GSTT1/GSTM3/GSTK1	-1.48455194199758
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/944	49/9376	0.405396056727776	CREB5/CREB3	-1.39624352805919
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/944	50/9376	0.39728813559322	AOC1/SMS	-1.42972783912984
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/944	66/9376	0.451463790446841	HSD17B1/HSD3B1/HSD17B11	-1.4962658532074
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/944	67/9376	0.444725524917784	ACSS1/FBP1/BPGM	-1.526159529647
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/944	34/9376	0.292123629112662	POLR2C	-1.38351311108643
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/944	68/9376	0.438185443668993	DHRS4L2/ALDH1A1/ALDH1A3	-1.5556990726248
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/944	138/9376	0.575779906656841	CPEB2/SMC1B/ITPR2/ADCY7/SKP1/SLK/CALM2/PPP2CB	-1.67976348342482
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/944	69/9376	0.431834929992631	CREB5/CALM2/CREB3	-1.58489521864836
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/944	154/9376	0.580453444860224	BCAT1/NME4/PNPO/MOCS2/NME3/QPRT/BCAT2/PPCS/AK9	-1.75644395740078
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/944	36/9376	0.275894538606403	FGGY	-1.4564177785329
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/944	36/9376	0.275894538606403	AGL	-1.4564177785329
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/944	36/9376	0.275894538606403	POLD4	-1.4564177785329
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/944	115/9376	0.518201915991157	DUSP1/GNG5/KRAS/ALOX5/PTGS2/ITPR2	-1.73936762829251
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/944	37/9376	0.268437929454879	CMAS	-1.49179171604996
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/944	56/9376	0.354721549636804	MAN1A1/FUT8	-1.62046462758482
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/944	117/9376	0.509343763581052	SMARCA1/SRCAP/BAZ2B/BRD7/BCL7C/BCL7B	-1.78687654617681
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/944	103/9376	0.48214579562284	COL17A1/SLC7A7/SLC8A1/ATP1B1/MME	-1.76816310999621
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/944	90/9376	0.441431261770245	AQP9/ADCY7/SLC4A2/ATP1B1	-1.78151661501423
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/944	44/9376	0.225731895223421	POLD4	-1.72241055774338
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/944	97/9376	0.409575397518784	GNG5/ADCY7/CALM2/PER3	-1.95571723050734
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/944	103/9376	0.385716636498272	PPP2R2B/DDX19B/SYMPK/PPP2CB	-2.0974111501798
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/944	191/9376	0.520010648682226	GNG5/KRAS/CREB5/CRH/SLC29A3/SOS1/CALM2/CREB3/HDAC7/SOS2	-2.24241010730626
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/944	110/9376	0.361171032357473	KRAS/CPEB2/PIK3CA/ADCY7	-2.25497188788477
NA	NA	hsa04082	Neuroactive ligand signaling	9/944	199/9376	0.449195128183289	TAC3/ADRB1/GNG5/P2RY6/SLC6A2/GNA11/SLC1A3/ADCY7/SLC1A6	-2.62772723103716
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/944	63/9376	0.157654022060802	PLOD2	-2.24451398737642
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/944	108/9376	0.275894538606403	EEF1A1/UBE2I/DDX19B	-2.5323692110233
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	16/944	370/9376	0.429500687127806	CSH1/CSH2/KISS1/TAC3/ADRB1/C5AR1/FPR3/P2RY6/C3AR1/PTGER4/CRH/BDKRB2/GH2/CHRNB1/FPR1/NR3C1	-3.74624652246838
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/944	183/9376	0.108548670927109	REXO2/XRN1	-4.07474924568869
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/944	243/9376	0.163493059914906	CTNNBL1/HSPA6/HSPA1A/SART1	-4.42050913960384
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/944	449/9376	0.132724321467668	RGS2/CNGB1/SLC8A1/ARRB1/CALM2/ARRB2	-6.30135441600638