category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	107/1142	222/9376	3.95714804121109	RPS26/RPL38/RPSA/RPL22/RPS29/RPS5/RPL14/RPL36/UBA52/RPL29/RPL23A/RPL24/RPS13/RPL23/RPL27A/RPL37A/RPS27/RPL26/RPS7/RPL15/RPL9/RPL39/RPS3/RPS15/RPL37/RPL21/RPL18A/RPS16/RPS19/RPS11/RPS23/RPLP2/RPL18/RPS3A/RPS6/RPL6/RPL11/RPL8/RPL32/RPS4X/RPS24/RPS27A/RPS14/RPL13A/RPS12/RPS2/RPS18/RPL13/RPS28/RPLP1/RPS20/RPL10A/RPL31/RPL5/RPS25/RPL7A/RPL27/RPL34/RPL30/RPL35/RPS15A/RPLP0/RPL28/RPL19/RPL7/RPL4/RPS10/RPL17/RPS9/MRPS15/RPL10/RPS21/MRPS22/DAP3/MRPL47/MRPS7/MRPL19/RPL36A/RPL22L1/MRPL44/MRPL42/MRPL4/MRPS5/MRPL9/MRPS9/MRPL49/MRPL55/MRPS35/MRPL46/RPL26L1/MRPL35/MRPL23/MRPL22/MRPL1/MRPL20/RPL3/MRPS28/RPS27L/MRPS18C/MRPL17/MRPS27/MRPL11/MRPL39/MRPS16/MRPL13/MRPL38/MRPL15	16.6057065435678
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	87/1142	238/9376	3.00119207052348	RPS26/RPL38/RPSA/RPL22/RPS29/RPS5/RPL14/RPL36/UBA52/RPL29/RPL23A/RPL24/RPS13/RPL23/RPL27A/RPL37A/RPS27/RPL26/RPS7/RPL15/RPL9/RPL39/RPS3/RPS15/RPL37/RPL21/RPL18A/RPS16/RPS19/RPS11/RPS23/RPLP2/RPL18/RPS3A/RPS6/RPL6/RPL11/RPL8/RPL32/RPS4X/RPS24/RPS27A/RPS14/RPL13A/RPS12/RPS2/RPS18/RPL13/RPS28/RPLP1/RPS20/RPL10A/RPL31/RPL5/RPS25/RPL7A/RPL27/RPL34/RPL30/RPL35/RPS15A/RPLP0/RPL28/RPL19/RPL7/RPL4/RPS10/RPL17/RPS9/RPL10/RPS21/PIK3CB/ISG15/RPL36A/RPL22L1/MAPK3/CCL2/OAS3/RPL26L1/ADAM17/TBK1/IFNAR2/RPL3/RPS27L/TNF/IRF3/MAPK9	11.6456821848193
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	60/1142	158/9376	3.11778137400519	CCNE1/CCNB1/CDKN1C/PTTG1/WEE1/SKP2/YWHAE/CDC20/CDK1/CCNB2/AURKB/CCNA2/CDT1/MAD2L1/CDK7/ORC6/ANAPC11/CCND3/CDC6/YWHAZ/PKMYT1/CDCA5/MCM5/RBX1/MCM4/PLK1/PCNA/CUL1/MCM7/E2F4/BUB3/CDC45/HDAC8/TTK/PPP2R5A/ORC5/HDAC1/BUB1B/MCM2/CDK2/ORC4/PPP2R1B/CDC23/TICRR/ESCO2/MDM2/CCNE2/CDC25A/ANAPC4/TGFB1/YWHAB/CDC25C/BUB1/ORC1/EP300/ANAPC15/E2F5/SFN/TRIP13/ANAPC1	9.99780299381358
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	88/1142	368/9376	1.96329856087718	TUBA1C/TUBA1B/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/MT-ND2/MT-ND5/GPX3/COX4I1/PFN1/COX5B/TUBB4B/CHCHD10/HNRNPA1/UQCR10/COX5A/PSMA7/COX7B/MT-ND6/PSMA4/SRSF3/SOD1/COX7C/NDUFB11/PSMD6/NDUFAB1/MT-ND4L/RAC1/HNRNPA2B1/SDHB/NUP62/CASP3/COX8C/RAB8A/VDAC1/NUP54/PSMD12/PPP3R1/NDUFS5/HNRNPA3/TUBB/NDUFA11/NDUFA6/APAF1/NDUFA9/DCTN5/NUP98/NDUFS3/COX6B1/CASP9/NOS2/TOMM40/TBK1/NUP107/TNF/NUP85/NCBP1/NUP50/PSMB6/PSMC3/PSMD14/PSMB3/TARDBP/GRIN2D/TRAF2/NUP153/ATXN2L/MAP2K6/NUP93/NDUFB2/ITPR3/PPP3CA/NXF1/NDUFA3/SDHA/PSMB2/NRG4/COX6A1/NDUFV2/NUP43/NDUFS4/SIGMAR1	7.0207561793072
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	39/1142	116/9376	2.76031161302011	GCSH/GAPDH/ALDOA/ENO1/TPI1/PKM/GLDC/IDH2/PHGDH/IDH1/PFKP/GPT2/TALDO1/SDHB/GOT1/IDH3B/PRPS2/TKT/ACOX1/MCEE/HK1/PSAT1/GLYCTK/FH/PGK1/ACAT2/SHMT1/PCCB/ACOX3/IDH3G/SUCLG1/ACSS2/SDHA/DLAT/GOT2/HK2/PGP/PDHA1/RPIA	7.10438214605982
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	69/1142	275/9376	2.06000318420634	TUBA1C/TUBA1B/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/MT-ND2/MT-ND5/COX4I1/HSPA8/SLC25A5/COX5B/TUBB4B/UQCR10/COX5A/PSMA7/COX7B/MT-ND6/PSMA4/SOD1/PIK3CB/COX7C/NDUFB11/PSMD6/NDUFAB1/MT-ND4L/RAC1/SDHB/CASP3/COX8C/CSNK2A2/VDAC1/PSMD12/PPP3R1/MAPK3/NDUFS5/TUBB/NDUFA11/NDUFA6/APAF1/NDUFA9/NDUFS3/COX6B1/CASP9/TNF/PSMB6/PSMC3/PSMD14/PSMB3/STIP1/GRIN2D/ITPR1/NDUFB2/ITPR3/PPP3CA/NDUFA3/SDHA/PSMB2/NCF4/COX6A1/CREB3L4/NDUFV2/NDUFS4/MAPK9	6.64419268041251
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	56/1142	205/9376	2.24277476399983	COL3A1/UQCRH/GAPDH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/MT-ND2/MT-ND5/COX4I1/SLC25A5/COX5B/PPP1CB/COL1A1/UQCR10/COX5A/COX7B/MT-ND6/PIK3CB/COX7C/NDUFB11/NDUFAB1/MT-ND4L/RAC1/GFPT1/PRKCZ/SDHB/COX8C/COL1A2/VDAC1/NDUFS5/NDUFA11/NDUFA6/NDUFA9/AKT1/SLC2A1/NDUFS3/COX6B1/GSR/PPP1CC/TGFB1/PLCB3/NDUFB2/CPT2/NDUFA3/SDHA/NCF4/COX6A1/NDUFV2/PDHA1/NDUFS4/MAPK9	6.69999175782881
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	66/1142	268/9376	2.02190448806754	TUBA1C/TUBA1B/CALM1/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/UBA52/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/RPS27A/MT-ND2/MT-ND5/COX4I1/SLC25A5/COX5B/TUBB4B/GNAS/UQCR10/COX5A/PSMA7/COX7B/MT-ND6/PSMA4/UBB/SOD1/COX7C/NDUFB11/PSMD6/NDUFAB1/MT-ND4L/SDHB/CASP3/COX8C/VDAC1/PSMD12/NDUFS5/TUBB/NDUFA11/SLC39A8/NDUFA6/APAF1/NDUFA9/NDUFS3/COX6B1/ADCY5/CASP9/CALM3/TXN2/PSMB6/PSMC3/PSMD14/PSMB3/ITPR1/NDUFB2/ITPR3/NDUFA3/SDHA/PSMB2/COX6A1/NDUFV2/NDUFS4/MAPK9	6.32090773965724
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	40/1142	138/9376	2.37975583136628	UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/MT-ND2/MT-ND5/COX4I1/COX5B/UQCR10/COX5A/COX7B/MT-ND6/ATP6V1C2/ATP6V1B1/COX7C/NDUFB11/NDUFAB1/MT-ND4L/SDHB/COX8C/NDUFS5/NDUFA11/NDUFA6/NDUFA9/NDUFS3/COX6B1/ATP6V1A/PPA1/ATP6V1E1/NDUFB2/NDUFA3/SDHA/COX6A1/NDUFV2/NDUFS4	6.08087479367927
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	56/1142	235/9376	1.95646309199985	UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/RPS6/MT-ND2/MT-ND5/COX4I1/PPARG/COX5B/GNAS/UQCR10/COX5A/COX7B/MT-ND6/COX7C/NDUFB11/NDUFAB1/MT-ND4L/SDHB/COX8C/NDUFS5/COX19/NDUFA11/NDUFA6/NDUFA9/SMARCA2/NRAS/NDUFS3/RPS6KB2/COX6B1/ADCY5/PRKAB2/ARID1A/TSC1/COA7/MLST8/COX16/RPS6KA1/GRB2/SMARCD2/NDUFB2/CPT2/NDUFA3/SDHA/ACSL4/COX6A1/CREB3L4/NDUFV2/COA6/NDUFS4	5.52991621955026
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	68/1142	308/9376	1.81263220142379	TUBA1C/TUBA1B/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/MT-ND2/MT-ND5/GPX3/COX4I1/PPARG/SLC25A5/COX5B/TUBB4B/UQCR10/COX5A/PSMA7/COX7B/MT-ND6/PSMA4/SOD1/CLTA/COX7C/NDUFB11/PSMD6/NDUFAB1/MT-ND4L/SDHB/CASP3/COX8C/VDAC1/PSMD12/NDUFS5/TUBB/NDUFA11/NDUFA6/APAF1/NDUFA9/DCTN5/HDAC1/NDUFS3/COX6B1/CASP9/POLR2D/POLR2F/PSMB6/PSMC3/PSMD14/PSMB3/TBPL1/TRAF2/EP300/ITPR1/PLCB3/NDUFB2/NDUFA3/SDHA/PSMB2/COX6A1/CREB3L4/NDUFV2/NDUFS4/MAPK9	5.40041194334971
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	54/1142	227/9376	1.95307714265876	MGST3/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/MT-ND2/MT-ND5/COX4I1/SLC25A5/COX5B/UQCR10/COX5A/COX7B/MT-ND6/SOD1/PIK3CB/COX7C/NDUFB11/NDUFAB1/MT-ND4L/RAC1/SDHB/COX8C/VDAC1/GSTA3/MAPK3/NDUFS5/NDUFA11/NDUFA6/NDUFA9/AKT1/GSTM4/ARNT/NRAS/NDUFS3/COX6B1/HMOX1/PRKD3/PLD2/GRB2/NDUFB2/NDUFA3/SDHA/COX6A1/EPHX1/NDUFV2/BRAF/NDUFS4/MAPK9	5.41336645908251
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	38/1142	138/9376	2.26076803979796	CCNE1/CCNB1/CALM1/PTTG1/PPP1CB/YWHAE/CDC20/CDK1/CCNB2/AURKA/MAD2L1/ANAPC11/YWHAZ/PKMYT1/RBX1/PLK1/PPP3R1/CUL1/MAPK3/PPP2R5A/ADCY5/CPEB4/CDK2/CALM3/PPP2R1B/CDC23/PPP1CC/CCNE2/ANAPC4/YWHAB/CDC25C/BUB1/ANAPC15/RPS6KA1/ITPR1/ITPR3/PPP3CA/ANAPC1	5.55647051427366
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	80/1142	388/9376	1.69281600375539	TUBA1C/TUBA1B/CALM1/UQCRH/GAPDH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/MT-ND2/MT-ND5/COX4I1/CTNNB1/SLC25A5/COX5B/TUBB4B/UQCR10/COX5A/PSMA7/COX7B/MT-ND6/PSMA4/WNT7A/PIK3CB/NCSTN/COX7C/NDUFB11/NAE1/PSMD6/NDUFAB1/CAPN1/MT-ND4L/SDHB/CASP3/COX8C/CSNK2A2/VDAC1/PSMD12/PPP3R1/MAPK3/NDUFS5/TUBB/NDUFA11/SLC39A8/NDUFA6/APAF1/NDUFA9/AKT1/ADAM17/NRAS/NDUFS3/COX6B1/CASP9/NOS2/DVL3/CALM3/TNF/PSMB6/PSMC3/PSMD14/PSMB3/GRIN2D/TRAF2/ITPR1/PLCB3/NDUFB2/ITPR3/PPP3CA/NDUFA3/SDHA/PSMB2/COX6A1/NDUFV2/BRAF/NDUFS4/MAPK9	5.19057536130412
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	41/1142	157/9376	2.14405390029783	LEP/UQCRH/MT-CO3/MT-CO2/MT-CYB/MT-CO1/COX4I1/PPARG/COX5B/UQCR10/COX5A/COX7B/PIK3CB/COX7C/NDUFB11/NDUFAB1/RAC1/SDHB/CASP3/COX8C/ADIPOR2/NDUFS5/RXRA/NDUFA11/NDUFA6/NDUFA9/AKT1/NDUFS3/COX6B1/PRKAB2/CDC42/TNF/TRAF2/TGFB1/NDUFB2/NDUFA3/SDHA/COX6A1/NDUFV2/NDUFS4/MAPK9	5.38353652101395
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	16/1142	36/9376	3.64895894142829	RPA3/SSBP1/RPA2/MCM5/MCM4/PCNA/MCM7/RFC3/POLE3/LIG1/MCM2/POLD2/RNASEH2A/DNA2/RPA1/PRIM2	5.93015845462018
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	24/1142	75/9376	2.62725043782837	GAPDH/ALDOA/ENO1/TPI1/PKM/IDH2/PHGDH/IDH1/PFKP/GPT2/TALDO1/ARG2/GOT1/IDH3B/PRPS2/TKT/BCAT2/PSAT1/PGK1/SHMT1/IDH3G/MAT2A/GOT2/RPIA	5.26906389919836
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	88/1142	480/9376	1.50519556333917	TUBA1C/TUBA1B/CALM1/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/UBA52/MT-ATP6/MT-CO2/MT-CYB/MT-CO1/RPS27A/MT-ND2/MT-ND5/GPX3/COX4I1/CTNNB1/SLC25A5/COX5B/TUBB4B/UQCR10/COX5A/PSMA7/COX7B/MT-ND6/PSMA4/WNT7A/UBB/SOD1/COX7C/NDUFB11/PSMD6/NDUFAB1/CAPN1/MT-ND4L/RAC1/SDHB/CASP3/COX8C/BAK1/CSNK2A2/RAB8A/VDAC1/PSMD12/PPP3R1/MAPK3/NDUFS5/TUBB/NDUFA11/NDUFA6/APAF1/NDUFA9/DCTN5/NRAS/NDUFS3/COX6B1/CASP9/NOS2/TOMM40/DVL3/TBK1/CALM3/TNF/PSMB6/PSMC3/PSMD14/PSMB3/TARDBP/GRIN2D/TRAF2/ATXN2L/MAP2K6/ITPR1/PLCB3/NDUFB2/ITPR3/PPP3CA/NDUFA3/SDHA/PSMB2/COX6A1/NDUFV2/BRAF/NDUFS4/SIGMAR1/MAPK9	4.23151630149071
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	22/1142	75/9376	2.40831290134267	CCNE1/CCNB1/PERP/RRM2/CDK1/CCNB2/CCND3/SIVA1/GTSE1/CASP3/APAF1/SHISA5/CASP9/RPRM/CDK2/SESN2/EI24/MDM2/CCNE2/SFN/TNFRSF10B/PPP1R13L	4.56014052584488
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	28/1142	108/9376	2.12855938249984	RAN/RBM8A/KPNA2/TMEM33/NUP62/THOC6/NUP54/UPF1/SAP18/NUP98/TNPO1/AAAS/XPO6/SENP2/NUP107/NUP85/NCBP1/NUP50/XPO1/MAGOHB/NUP153/THOC7/NUP93/NXF1/IPO4/IPO7/NUP43/XPOT	4.39295282725751
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	28/1142	110/9376	2.08985830281802	CCNB1/HSP90AB1/HSP90AA1/CDK1/CCNB2/AURKA/CCNA2/MAD2L1/PIK3CB/ANAPC11/PKMYT1/PLK1/MAPK3/AKT1/ADCY5/CPEB4/CDK2/CDC23/CDC25A/ANAPC4/CDC25C/BUB1/ANAPC15/RPS6KA1/KIF22/ANAPC1/BRAF/MAPK9	4.28187012667769
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/1142	23/9376	3.56963374704942	RPA3/SSBP1/RPA2/PCNA/RFC3/LIG1/POLD2/MSH6/EXO1/RPA1	4.59486691316427
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	14/1142	41/9376	2.80346845499979	RPA3/SSBP1/RPA2/BABAM1/RAD51/XRCC2/POLD2/TOPBP1/BRCC3/BLM/RPA1/RAD51C/RAD52/RAD54L	4.30979463696818
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	27/1142	110/9376	2.01522050628881	GAPDH/RPS6/FLT1/ALDOA/ENO1/LDHB/LDHA/PIK3CB/PFKP/EGLN3/EPAS1/RBX1/MKNK1/MAPK3/ERBB2/AKT1/HK1/SLC2A1/ARNT/RPS6KB2/NOS2/PGK1/HMOX1/ANGPT4/EP300/HK2/PDHA1	3.98863076661305
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	12/1142	33/9376	2.9855118611686	IDH2/IDH1/GPT2/GOT1/IDH3B/BCAT2/DHTKD1/IDH3G/DLAT/GOT2/BCKDHB/PDHA1	4.25499976231634
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	18/1142	63/9376	2.34575931948962	CDK7/RPA3/RPA2/GTF2H3/MNAT1/RBX1/PCNA/RFC3/CUL4A/POLE3/LIG1/CUL4B/POLR2D/POLD2/ERCC2/POLR2F/UVSSA/RPA1	3.99122423581549
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/1142	30/9376	3.01039112667834	IDH2/IDH1/SDHB/IDH3B/FH/ACLY/IDH3G/SUCLG1/SDHA/DLAT/PDHA1	4.10715938392127
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	34/1142	157/9376	1.77799591732016	HLA-G/CCNE1/CCNB1/CALM1/SLC25A5/PPP1CB/CDK1/CCNB2/CCNA2/PIK3CB/RAD1/CCND3/CAPN1/MYBL2/VDAC1/PPP3R1/MAPK3/E2F4/AKT1/NRAS/TSC1/CDK2/CALM3/FOXM1/PPP1CC/MDM2/CCNE2/CDC25A/TGFB1/E2F5/MAP2K6/ITPR1/ITPR3/PPP3CA	3.66098960285213
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	18/1142	67/9376	2.20571398698277	GAPDH/ALDOA/ENO1/TPI1/PKM/LDHB/LDHA/PFKP/PGM2/HK1/PGK1/PGM1/ACSS2/ALDH3B2/DLAT/HK2/PDHA1/ALDH1B1	3.68844612227776
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	21/1142	87/9376	1.98176218370675	UQCRH/MT-CO3/MT-CO2/MT-CYB/MT-CO1/TPM1/COX4I1/COX5B/UQCR10/COX5A/COX7B/COX7C/MYL4/COX8C/TNNC1/TPM3/COX6B1/TNNT2/MYL3/ATP1A4/COX6A1	3.42605793992514
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/1142	54/9376	2.28059933839268	LDHB/LDHA/PHGDH/GOT1/ENOPH1/BCAT2/SMS/APIP/PSAT1/MTAP/AMD1/MAT2A/DNMT1/DNMT3B/GOT2	3.51454301074307
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	30/1142	142/9376	1.73454034187613	UBA52/RPS27A/UBE2C/UBE2S/SKP2/CDC20/UBB/ANAPC11/UBE2F/RBX1/CUL1/CUL4A/HERC4/FBXW7/CUL4B/NEDD4/CDC23/TRIM37/UBE2Q2/PRPF19/UBE4B/MDM2/MID1/ANAPC4/UBE2A/ANAPC15/UBE2N/UBE2K/ANAPC1/HERC3	3.28456717748943
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1142	71/9376	2.08144841025135	SLC16A3/PKM/LDHB/LDHA/IDH2/PIK3CB/IDH1/PFKP/SLC7A5/MAPK3/FGFR3/ERBB2/AKT1/HK1/SLC2A1/NRAS/HK2/PDHA1	3.40635613071482
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/1142	30/9376	2.73671920607122	TYMS/FOLR1/ABCG2/GGH/GART/SLC19A1/SHMT1/TNF/DHFR/SLC46A1	3.54805713664144
Genetic Information Processing	Transcription	hsa03040	Spliceosome	45/1142	243/9376	1.52039955892846	HSPA8/RBM8A/HNRNPA1/SNRPB/SNRPD1/SNRPF/SNRPD2/LSM7/HNRNPC/LSM4/SRSF3/LSM3/SF3A3/HNRNPK/SMNDC1/WBP11/THOC6/PPIL1/HNRNPM/HNRNPA3/PHF5A/EFTUD2/SF3B3/SNRNP70/DDX23/SNRPG/CTNNBL1/U2AF2/SNRPE/SNRNP200/PRPF38A/TCERG1/NCBP1/DHX15/SNRPD3/PRPF19/TRA2B/CHERP/MAGOHB/THOC7/SRSF9/RBMXL1/U2AF1/PRPF40B/SRSF6	3.06088199404204
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	11/1142	37/9376	2.44085767027974	PPARG/CTNNB1/CDH1/BAK1/CCDC6/MAPK3/NCOA4/RXRA/NRAS/TPM3/BRAF	3.27028058414357
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	10/1142	32/9376	2.56567425569177	AKR1B1/B4GALT1/UGP2/PFKP/PGM2/GAA/HK1/GALK1/PGM1/HK2	3.30387223046998
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/1142	32/9376	2.56567425569177	LDHB/LDHA/ACOX1/MCEE/PCCB/ACOX3/SUCLG1/ACSS2/EHHADH/BCKDHB	3.30387223046998
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	17/1142	70/9376	1.99389542156617	PIK3CB/EGLN3/EPAS1/RAC1/RBX1/MAPK3/AKT1/SLC2A1/ARNT/NRAS/FH/CDC42/TGFB1/EP300/CRKL/GRB2/BRAF	3.1082893810974
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	40/1142	216/9376	1.52039955892846	CALM1/HSP90AB1/HSP90AA1/PPARG/HSPA8/HSPD1/CCL3L1/PIK3CB/CCL3/RAC1/CASP3/PPP3R1/MAPK3/CCL2/RXRA/HSPA2/CASP6/APAF1/AKT1/NRAS/HSPA4/CASP9/CYP2J2/TBK1/CALM3/CDC42/TNF/CXCL1/TRAF2/IRF3/VLDLR/MAP2K6/ITPR1/PLCB3/PPP3CA/NCF4/VAV3/MAPK9/POU2F1/TNFRSF10B	2.88157095080631
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	19/1142	83/9376	1.87943367163927	PRDX1/ECH1/IDH2/SOD1/IDH1/SLC27A2/ACOX1/PXMP2/MPV17L2/PMVK/NOS2/NUDT7/ACOX3/ABCD1/HACL1/ACSL4/EHHADH/FAR2/CROT	2.99693570758256
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	41/1142	224/9376	1.50275206404804	HLA-G/CCNE1/CALR/PTTG1/RANBP1/SLC25A5/RAN/CDC20/CCNB2/MSX2/CCNA2/MAD2L1/PIK3CB/ANAPC11/CCND3/VDAC1/PPP3R1/MAPK3/BUB3/AKT1/SLC2A1/NRAS/BUB1B/NFYB/ADCY5/CDK2/CDC23/IL2RB/TNF/TBPL1/CCNE2/ANAPC4/XPO1/TGFB1/EP300/ANAPC15/PPP3CA/EGR2/ANAPC1/CREB3L4/MAPK9	2.83617565306584
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1142	78/9376	1.89465175804931	ENO1/HSPD1/LSM7/LSM4/LSM3/EXOSC3/PFKP/PARN/EXOSC10/HSPA9/CNOT6/CNOT7/EXOSC9/CNOT1/PAN3/EXOSC2/BTG3/EXOSC8	2.9547436564388
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/1142	50/9376	2.13464098073555	CKMT1A/CKMT1B/ARG2/GOT1/SMS/NOS2/CNDP2/GAMT/ODC1/AMD1/GOT2/P4HA1/ALDH1B1	2.99577381682842
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	39/1142	214/9376	1.49624367808567	HLA-G/CCNB1/CALM1/CALR/WEE1/CDK1/CCNB2/RAC3/AP1M2/PIK3CB/RAC1/AP1S1/CASP3/BAK1/RBX1/PPP3R1/CUL1/MAPK3/AP1G1/CUL4A/AP1B1/AKT1/GNG12/NRAS/RPS6KB2/CASP9/CUL4B/TBK1/CALM3/TNF/TRAF2/CDC25C/IRF3/CRKL/MAP2K6/ITPR1/ITPR3/PPP3CA/MAPK9	2.73476484753495
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/1142	57/9376	2.01652994131564	TECR/SCD/ELOVL2/ACOX1/OXSM/ACAT2/HSD17B8/MECR/ACOX3/HADH/CPT2/FADS2/ACSL4/EHHADH	2.86672613556985
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1142	20/9376	2.87355516637478	SQLE/DHCR24/NSDHL/MSMO1/CYP51A1/EBP/LBR	3.12355843741151
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	12/1142	46/9376	2.14178024822965	HCCS/ALAS2/FXN/CP/HMBS/HMOX1/ALAS1/EARS2/FECH/CPOX/BLVRB/ALAD	2.89090538851378
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	22/1142	106/9376	1.7039949773651	CCNE1/HSP90AB1/HSP90AA1/GSTP1/CTNNB1/FOLR1/SPINT1/PIK3CB/MAPK3/ERBB2/AKT1/NRAS/CASP9/SLC19A1/CDK2/MDM2/CCNE2/EP300/SLC46A1/GRB2/CREB3L4/BRAF	2.71453774674478
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	44/1142	253/9376	1.42785349881977	UBA52/RPS27A/PFN1/ARPC3/UBB/PIK3CB/UBE2V1/BNIP3/CAPN1/CASP4/RAC1/RBX1/ARPC1B/VDAC1/CUL1/MAPK3/ATG12/AKT1/HK1/CBX3/RPS6KB2/FOXO4/ARPC5L/TBK1/CDC42/TNF/ELMO1/PLCD4/HCLS1/DIAPH1/MDM2/TRAF2/TECPR1/IRF3/CRKL/ARF6/ITPR1/GLMN/PLCB3/ITPR3/UBE2N/U2AF1/HK2/MAPK9	2.56921098252855
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/1142	101/9376	1.70706247507413	COL3A1/FN1/COL4A1/COL1A1/COL4A2/PIK3CB/RAC1/PRKCZ/CASP3/COL1A2/MAPK3/CCL2/AKT1/NRAS/CDC42/TNF/PLCD4/DIAPH1/TGFB1/PLCB3/MAPK9	2.66057052664662
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	9/1142	31/9376	2.38359414722332	ALDOA/PFKP/TALDO1/PRPS2/TKT/PGM2/GLYCTK/PGM1/RPIA	2.87351301887788
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1142	31/9376	2.38359414722332	GCSH/GLDC/MCEE/GLYCTK/ACAT2/SHMT1/PCCB/ACSS2/PGP	2.87351301887788
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/1142	59/9376	1.94817299415239	MGST3/PRDX6/GSTP1/GPX3/RRM2/IDH2/IDH1/GSTA3/SMS/GSTM4/GSR/GGCT/ODC1/RRM1	2.72075100641629
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	29/1142	154/9376	1.54606864239088	UGP2/GGH/AK5/QPRT/GCH1/ALAS2/BCAT2/FLAD1/OXSM/UMPS/PSAT1/HMBS/PPCDC/PDXK/SHMT1/NFS1/KMO/ALAS1/AK2/EARS2/FECH/DHFR/MAT2A/GGCX/DHODH/CPOX/NADK2/ALAD/ALDH1B1	2.54453423562429
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	21/1142	103/9376	1.67391563089793	PPP1CB/RBM8A/PAPOLA/UPF1/SAP18/PPP2R5A/NUDT21/CSTF3/PPP2R1B/CPSF3/NCBP1/DAZAP1/PABPN1/CPSF4/TARDBP/PPP1CC/MAGOHB/NXF1/GSPT1/SMG5/SSU72	2.56110433277133
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/1142	156/9376	1.52624724953972	CLDN7/CLDN4/CTNNB1/YWHAE/CLDN19/EIF3E/PIK3CB/CLDN6/YWHAZ/CASP3/BAK1/MAPK3/RXRA/OAS3/APAF1/AKT1/CLDN3/NRAS/CASP9/TBK1/IFNAR2/CDK2/PPP2R1B/TNF/TRAF2/YWHAB/IRF3/GRB2/BRAF	2.46831132856829
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	15/1142	67/9376	1.83809498915231	CALM1/PPP1CB/PPP3R1/MAPK3/NRAS/CALM3/PPP1CC/GRIN2D/EP300/RPS6KA1/ITPR1/PLCB3/ITPR3/PPP3CA/BRAF	2.56384867905114
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	31/1142	170/9376	1.49714638920367	EZR/TUBA1C/TUBA1B/CLDN7/CLDN4/F11R/ARPC3/CLDN19/RAB8B/CLDN6/RAC1/PRKCZ/ARPC1B/RAB8A/PCNA/ERBB2/CLDN3/HSPA4/PRKAB2/ARPC5L/NEDD4/PARD6B/PPP2R1B/CDC42/TJP3/HCLS1/TIAM1/CRB3/RAPGEF2/MAPK9/MYH10	2.43605182712633
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/1142	137/9376	1.55813210272668	TUBA1C/TUBA1B/BIRC5/CTSV/LMNB1/PIK3CB/CAPN1/CASP3/BAK1/AIFM1/DFFA/MAPK3/CASP6/APAF1/AKT1/LMNB2/NRAS/CASP9/CSF2RB/TNF/TRAF2/PARP2/ITPR1/ITPR3/MAPK9/TNFRSF10B	2.45074464241894
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	11/1142	44/9376	2.05253940455342	HMGB1/NEIL2/PCNA/RFC3/POLE3/LIG1/SMUG1/POLD2/LIG3/PARP2/NTHL1	2.6060971168163
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	36/1142	205/9376	1.44178377685703	HLA-G/CCNE1/RANBP1/SKP2/PKM/YWHAE/CDC20/CDK1/CCNA2/PIK3CB/CCND3/GTF2H3/RAC1/YWHAZ/HNRNPK/CASP3/BAK1/MAPK3/HDAC8/HDAC1/NRAS/CDK2/CDC42/DNAJA3/TBPL1/MDM2/TRAF2/GTF2B/CCNE2/YWHAB/EP300/IRF3/GRB2/EGR2/CREB3L4/DDX3X	2.3817249508335
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	39/1142	227/9376	1.41055571414243	HLA-G/CALM1/CALR/CTNNB1/GNAS/CCL3L1/RAC3/CCL4/PIK3CB/CCL3/RAC1/CASP3/BAK1/PPP3R1/MAPK3/CCL2/AKT1/GNG12/NRAS/RPS6KB2/ADCY5/CASP9/TBK1/TSC1/CALM3/TNF/MDM2/TRAF2/IRF3/CRKL/MAP2K6/ITPR1/GRB2/PLCB3/ITPR3/PPP3CA/IL10RA/CCL4L2/CREB3L4	2.33190833464262
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/1142	23/9376	2.49874362293459	HMGCS1/ICMT/MVD/PMVK/PDSS2/ACAT2/NUS1	2.67996460283321
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1142	75/9376	1.75150029188558	MGST3/GSTP1/TOP2A/BIRC5/PIK3CB/CASP3/BAK1/GSTA3/MAPK3/ERBB2/APAF1/AKT1/GSTM4/CASP9/MSH6/MDM2	2.43337040578445
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	21/1142	107/9376	1.61133934563072	CALM1/PKM/LDHB/GNAS/LDHA/PFKP/PPP3R1/PHKG2/AKT1/SLC2A1/PPP4C/PRKAB2/CALM3/EP300/ITPR1/PLCB3/ITPR3/PPP3CA/PYGL/CREB3L4/PDHA1	2.36848726726262
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	16/1142	76/9376	1.7284542354134	PPARG/PLIN2/SCD/FABP7/HMGCS1/SLC27A2/SLC27A6/PLTP/ACOX1/RXRA/DBI/ACOX3/CPT2/FADS2/ACSL4/EHHADH	2.3745474555936
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	11/1142	46/9376	1.96329856087718	POMP/PSMA7/PSMA4/PSMD6/PSMD12/PSMB6/PSMC3/PSMD14/PSMB3/PSMB2/PSME2	2.43900260554104
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1142	35/9376	2.11118338754066	ALDOA/AKR1B1/TPI1/PFKP/HK1/PFKFB4/GMDS/ENOSF1/HK2	2.45265427701551
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	16/1142	77/9376	1.70600677781063	RALBP1/RAC3/PIK3CB/RAC1/RAD51/BAK1/MAPK3/ERBB2/AKT1/RPS6KB2/CASP9/CDC42/TGFB1/PLD2/BRAF/MAPK9	2.31659101693148
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1142	19/9376	2.5926813531201	GCSH/GLDC/DHTKD1/DLAT/BCKDHB/PDHA1	2.58791876695606
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	26/1142	144/9376	1.48238956995524	SLC25A5/PSMA7/PSMA4/PIK3CB/PSMD6/VDAC1/PSMD12/AKT1/PUM1/PSMB6/PSMC3/PSMD14/PSMB3/TBPL1/GRIN2D/TRAF2/GTF2B/ATXN2L/OMA1/VLDLR/ITPR1/PLCB3/ITPR3/PSMB2/AFG3L2/MAPK9	2.17242361985334
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/1142	36/9376	2.05253940455342	UGP2/PGM2/GAA/HK1/AGL/PGM1/PYGL/GYG2/HK2	2.35629376926765
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	12/1142	54/9376	1.82447947071415	UBE2T/RPA3/RPA2/FANCE/RAD51/FANCI/BLM/RMI2/RPA1/RAD51C/FANCD2/FANCB	2.26274407180039
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	34/1142	200/9376	1.39572679509632	EZR/TUBA1C/TUBA1B/GAPDH/RPS3/CLDN7/CLDN4/NCL/TUBB4B/ARPC3/CLDN19/BAIAP2L1/CLDN6/CASP4/RAC1/CASP3/BAK1/ARPC1B/MAPK3/TUBB/SEC24A/CLDN3/MYO1B/CASP9/ARPC5L/CDC42/TNF/HCLS1/TRAF2/ARF6/CYFIP2/MAPK9/TNFRSF10B/MYH10	2.10667243165672
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/1142	37/9376	1.99706536659251	UGP2/GFPT1/PGM2/HK1/GALK1/PGM1/CMAS/GMDS/HK2	2.26301568624501
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1142	93/9376	1.58906276481555	CCNE1/FN1/COL4A1/CKS2/CKS1B/SKP2/COL4A2/PIK3CB/CASP3/BAK1/RXRA/APAF1/AKT1/CASP9/NOS2/CDK2/TRAF2/CCNE2	2.12604341754667
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/1142	87/9376	1.60428367252451	CTNNB1/BIRC5/RAC3/PIK3CB/RAC1/CASP3/BAK1/MAPK3/AKT1/NRAS/RPS6KB2/CASP9/MSH6/TGFB1/GRB2/BRAF/MAPK9	2.10877023843294
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1142	44/9376	1.86594491323038	CDK7/GTF2H3/MNAT1/TAF13/TAF3/TAF11/ERCC2/TBPL1/GTF2B/TAF15	2.14408746307122
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1142	27/9376	2.12855938249984	TECR/SCD/ELOVL2/ACOX1/ACOT7/ACOX3/FADS2	2.18694054710511
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	27/1142	158/9376	1.40300161830233	RPS6/SKP2/ATP6V1C2/WNT7A/ATP6V1B1/PIK3CB/SLC7A5/MAPK3/NPRL3/AKT1/NRAS/RPS6KB2/MIOS/SLC38A9/DVL3/STRADB/TSC1/MLST8/PRR5/TNF/SESN2/ATP6V1A/RPS6KA1/ATP6V1E1/GRB2/TBC1D7/BRAF	1.90252442269564
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1142	85/9376	1.54544143401669	RRM2/TYMS/TK1/PNP/AK5/APRT/GMPS/IMPDH1/UCKL1/IMPDH2/ITPA/ADK/AK2/RRM1/HDDC2/UCK2	1.88122013026983
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	33/1142	204/9376	1.32811373235809	EZR/RPS6/FN1/CTNNB1/IGF2/PPP1CB/COL1A1/GPC3/SDC4/WNT7A/PIK3CB/RAC1/CASP3/COL1A2/ERBB3/MAPK3/ERBB2/AKT1/SDC1/NRAS/RPS6KB2/CDC42/TNF/HCLS1/PPP1CC/MDM2/TGFB1/TIAM1/ITPR1/GRB2/ITPR3/VAV3/BRAF	1.76449619654745
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/1142	47/9376	1.74684204642844	PKM/LDHB/LDHA/FH/ACAT2/ACYP1/ACSS2/DLAT/PDHA1/ALDH1B1	1.91149603519011
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/1142	41/9376	1.80222972107129	GCSH/GLDC/PHGDH/ALAS2/PSAT1/GLYCTK/SHMT1/GAMT/ALAS1	1.91710885760402
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	34/1142	212/9376	1.3167233916003	PGF/CALM1/FLT1/EFNA1/PFN1/CTNNB1/GNAS/ID1/RAC3/CDH1/PIK3CB/FLT4/RAC1/PRKCZ/MAPK3/FGFR3/AKT1/NRAS/ADCY5/PRKD3/PARD6B/ANGPT4/CALM3/CDC42/CTNND1/TIAM1/CRKL/NGFR/MAP2K6/PLCB3/EFNA4/VAV3/BRAF/RAPGEF2	1.7370758736856
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	27/1142	163/9376	1.35996475884521	CCNE1/BIRC5/CCNA2/PIK3CB/YWHAZ/CASP3/PCNA/MAPK3/APAF1/AKT1/NRAS/CASP9/TBK1/CDK2/TNF/CCNE2/TGFB1/YWHAB/EP300/IRF3/MAP2K6/GRB2/EGR2/CREB3L4/BRAF/DDX3X/MAPK9	1.7264997115761
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/1142	149/9376	1.37754322453249	MT-ND1/MT-ND3/MT-ND4/MT-ND2/MT-ND5/MT-ND6/NDUFB11/NDUFAB1/MT-ND4L/MAPK3/NDUFS5/NDUFA11/NDUFA6/NDUFA9/GNG12/NDUFS3/ADCY5/ITPR1/PLCB3/NDUFB2/ITPR3/NDUFA3/NDUFV2/NDUFS4/MAPK9	1.72998689575122
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	10/1142	48/9376	1.71044950379451	HMGCS1/BCAT2/MCEE/ACAT2/PCCB/HADH/HIBADH/EHHADH/BCKDHB/ALDH1B1	1.83769242035827
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	23/1142	138/9376	1.36835960303561	CALM1/RPS6/PPP1CB/PTPRF/PIK3CB/PRKCZ/MKNK1/MAPK3/PHKG2/AKT1/HK1/NRAS/RPS6KB2/PRKAB2/TSC1/CALM3/PPP1CC/CRKL/GRB2/PYGL/HK2/BRAF/MAPK9	1.62343841873158
NA	NA	hsa04981	Folate transport and metabolism	7/1142	31/9376	1.85390655895147	TYMS/FOLR1/ABCG2/SLC19A1/SHMT1/DHFR/SLC46A1	1.77343306848798
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1142	63/9376	1.56383954632641	EZH2/SMYD2/COLGALT1/ACAT2/DHTKD1/HADH/KMT2C/SETDB1/PLOD1/EHHADH/SMYD3/ALDH1B1	1.67222327931763
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	36/1142	233/9376	1.26852220710597	DSP/COL3A1/DSC2/FN1/TPM1/COL4A1/ENO1/TNNI2/DSG2/CSRP2/COL1A1/SDC4/LMNB1/DIAPH3/PKP2/COL4A2/COL9A3/COL27A1/JUP/MYL4/COL1A2/FBN2/TNNC1/LMNB2/SDC1/TPM3/ITGB4/TNNT2/ACTG2/SYNE2/DIAPH1/COL6A1/MYL3/LBR/ATP1A4/MYH10	1.54570662250898
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/1142	205/9376	1.28158557942847	HLA-G/CCNE1/CALR/SKP2/CCNA2/PIK3CB/TNFAIP3/PSMD6/CCND3/ISG15/RAC1/CASP3/BAK1/PSMD12/OAS3/APAF1/AKT1/HDAC1/CASP9/TBK1/NEDD4/IFNAR2/CDK2/TNF/PSMC3/PSMD14/MDM2/TRAF2/CCNE2/IRF3/MAP2K6/MAPK9	1.51807158943443
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1142	32/9376	1.79597197898424	BIRC5/CASP3/BAK1/APAF1/CASP9/NGFR/MAPK9	1.67965316414833
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1142	78/9376	1.47361803403835	FN1/CTNNB1/CDH1/ARPC3/PIK3CB/CLTA/RAC1/ARPC1B/ARPC5L/CDC42/ELMO1/HCLS1/CD2AP/CRKL	1.56420626132912
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	6/1142	26/9376	1.89465175804931	PLA2G2A/PLA2G10/PLA2G12A/ACOX1/ACOX3/FADS2	1.7011716910045
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	49/1142	333/9376	1.20810127114856	HLA-G/CCNE1/FN1/COL4A1/CTNNB1/PKM/COL1A1/GNAS/CCNA2/COL4A2/ATP6V1C2/WNT7A/ATP6V1B1/COL9A3/PIK3CB/CCND3/ISG15/PRKCZ/CASP3/BAK1/COL1A2/MAPK3/AKT1/PPP2R5A/HDAC1/NRAS/HEY1/RPS6KB2/DVL3/TBK1/ITGB4/IFNAR2/TSC1/PARD6B/CDK2/PPP2R1B/CDC42/TNF/ATP6V1A/TBPL1/MDM2/CCNE2/COL6A1/EP300/IRF3/ATP6V1E1/GRB2/CRB3/CREB3L4	1.43997132289818
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1142	142/9376	1.32981426210503	CALM1/MGST3/HSP90AB1/HSP90AA1/GSTP1/CTNNB1/RAC3/SDC4/CDH5/PIK3CB/RAC1/PRKCZ/GSTA3/CCL2/AKT1/GSTM4/SDC1/HMOX1/CALM3/TXN2/TNF/MAP2K6/MAPK9	1.4747959209581
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/1142	59/9376	1.53070735254831	CTNNB1/CDH1/PIK3CB/BAK1/MAPK3/ERBB2/AKT1/NRAS/CASP9/GRB2/BRAF	1.52284717289286
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/1142	122/9376	1.34592747839568	DIO2/CTNNB1/PIK3CB/PFKP/MAPK3/RXRA/AKT1/SLC2A1/HDAC1/NRAS/CASP9/PLCD4/MED24/MED12L/MDM2/THRB/EP300/PLCB3/ATP1A4/NCOA2	1.43223237882573
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/1142	94/9376	1.39747363714275	HSP90AB1/HSP90AA1/S100A9/FOSB/TNFAIP3/S100A8/CASP3/MAPK3/CCL2/CCL20/TBK1/TNF/CXCL1/TRAF2/LCN2/MAPK9	1.44233031782361
NA	NA	hsa04382	Cornified envelope formation	33/1142	217/9376	1.24854931521222	KRT18/KRT8/KRT7/KRT19/DSP/S100A10/S100A11/CLDN7/COL4A1/CLDN4/KRT23/S100A9/DSG2/PRSS8/PKP3/CLDN19/PKP2/COL4A2/PADI1/S100A8/PCSK6/JUP/CLDN6/CAPN1/CLDN3/PPP2R5A/FURIN/BLMH/ITGB4/PPP2R1B/TCHH/S100A12/KRT15	1.37953164496141
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	44/1142	300/9376	1.20415645067134	PGF/FLT1/EFNA1/HSPA8/IGF2/DUSP9/RAC3/STMN1/IL1RAP/FLT4/RAC1/CASP3/PPP3R1/ERBB3/MKNK1/MAPK3/FGFR3/ERBB2/PPM1B/AKT1/GNG12/TAOK3/NRAS/ECSIT/RPS6KA4/MAP3K8/ANGPT4/CDC42/TNF/DUSP5/TRAF2/STK3/TGFB1/RASGRF2/CRKL/RPS6KA1/NGFR/MAP2K6/GRB2/PPP3CA/EFNA4/BRAF/RAPGEF2/MAPK9	1.33841177668519
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1142	47/9376	1.57215784178559	PKM/PIK3CB/PRKCZ/MAPK3/HK1/TNF/ABCC8/HK2/MAPK9	1.46440261539411
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	22/1142	138/9376	1.30886570725145	FN1/RAC3/ARPC3/PIK3CB/RAC1/ARPC1B/MAPK3/CCL2/AKT1/ARPC5L/TBK1/CDC42/TNF/ELMO1/TRAF2/IRF3/CRKL/RPS6KA1/MAP2K6/ARF6/VAV3/MAPK9	1.36123627902877
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1142	61/9376	1.48052022623525	MT1E/MT1G/MT1H/MT2A/MT1X/MT1F/SLC6A19/HMOX1/MT1A/SLC46A1/ATP1A4	1.40216273117576
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	18/1142	110/9376	1.34348033752587	ID3/ID1/BMP7/RBX1/CUL1/MAPK3/E2F4/GREM2/LRRC32/HDAC1/RPS6KB2/PITX2/PPP2R1B/TNF/TMEM53/TGFB1/EP300/E2F5	1.34947652603127
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1142	28/9376	1.75931948961721	TECR/ELOVL2/THEM4/ACOT7/MECR/HADH	1.49850249294905
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1142	103/9376	1.35507455834594	COL3A1/PRDX1/FN1/COL4A1/SERPINB9/COL1A1/GNAS/COL4A2/PIK3CB/ARG2/CASP3/COL1A2/NOS2/TNF/CXCL1/TGFB1/PLCB3	1.34940183628772
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1142	82/9376	1.40173422749989	MGST3/GSTP1/RRM2/TK1/GSTA3/GMPS/IMPDH1/UCKL1/GSTM4/UMPS/IMPDH2/ITPA/RRM1/UCK2	1.36068527775762
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1142	16/9376	2.05253940455342	MIF/GOT1/ALDH3B2/GOT2	1.5691833434578
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1142	69/9376	1.42785349881977	CALM1/PPP1CB/GNAS/FOSB/PPP3R1/HDAC1/ADCY5/CALM3/PPP1CC/GRIN2D/PPP3CA/CREB3L4	1.32839745555149
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/1142	56/9376	1.46609957468101	HSPA8/HSPD1/RAB1B/BNIP3/CASP3/APAF1/CASP9/TNF/CXCL1/BCL2L13	1.30280081862824
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1142	23/9376	1.78481687352471	GPT2/ARG2/GOT1/NOS2/GOT2	1.4033630626125
Cellular Processes	Cell motility	hsa04814	Motor proteins	29/1142	194/9376	1.22729160272266	TUBA1C/TUBA1B/TPM1/TNNI2/TUBB4B/KIF2C/KIF21A/KIF2A/CENPE/MYL4/KIF11/KIF4A/KIFC1/TUBB/DCTN5/TNNC1/MYO1B/TPM3/KIF23/KIF20A/TNNT2/ACTG2/KIF14/KIF20B/KIF18A/MYL3/KIF22/MYH10/KIF18B	1.19132120088882
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	20/1142	128/9376	1.28283712784588	RRM2/PNP/AK5/APRT/PRPS2/PGM2/GMPS/IMPDH1/HDDC3/IMPDH2/GART/ADCY5/PAICS/ITPA/ADK/PGM1/AK2/RRM1/HDDC2/PDE6H	1.19986048660522
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1142	99/9376	1.32689416051938	RAC3/PIK3CB/RAC1/MAPK3/LYPLA1/DGKZ/AKT1/SLC44A1/NRAS/RPS6KB2/SLC22A3/TSC1/PLD2/GRB2/SLC44A2/MAPK9	1.21768299306181
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/1142	43/9376	1.52747118478394	ACOX1/ACAT2/ACOX3/HADH/CPT2/ACSL4/EHHADH/ALDH1B1	1.29102779738284
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1142	50/9376	1.47782837127846	HBA2/HBA1/HBB/GYPB/GYPA/CCL2/SDC1/TNF/TGFB1	1.26160234639666
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/1142	196/9376	1.21476821902141	HLA-G/CALM1/UBA52/RPS27A/CTNNB1/UBB/PIK3CB/RAC1/CASP3/BAK1/PPP3R1/MAPK3/AKT1/GNG12/NRAS/CASP9/TBK1/IFNAR2/CALM3/CXCL1/TRAF2/PREX1/EP300/IRF3/MAP2K6/ITPR1/ITPR3/PPP3CA/MAPK9	1.13159226360809
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1142	93/9376	1.32421897067962	CTNNB1/PTPRF/RAC3/CDH5/CDH1/ARHGAP29/RAC1/CSNK2A2/PDCD10/MAPK3/ERBB2/CDC42/CTNND1/EP300/SSX2IP	1.17017005594134
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1142	93/9376	1.32421897067962	CGA/CALM1/GNAS/MAPK3/NRAS/ADCY5/CALM3/CDC42/MAP2K6/PLD2/ITPR1/GRB2/PLCB3/ITPR3/MAPK9	1.17017005594134
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/1142	130/9376	1.26310117203287	COL3A1/COL4A1/COL1A1/GNAS/COL4A2/PIK3CB/PRKCZ/COL1A2/MAPK3/AKT1/GNG12/NRAS/ADCY5/NOS2/RLN2/TGFB1/GRB2/PLCB3/CREB3L4/MAPK9	1.12494366188187
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1142	65/9376	1.38941128923616	CGA/KISS1/PIK3CB/KISS1R/MAPK3/AKT1/NRAS/ITPR1/PLCB3/ITPR3/KCNN4	1.17322230643019
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1142	18/9376	1.82447947071415	OXSM/HSD17B8/MECR/ACSL4	1.30388064085929
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1142	31/9376	1.58906276481555	ACOX1/CNDP2/ACOX3/ALDH3B2/EHHADH/ALDH1B1	1.22339309329303
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1142	109/9376	1.28048329825351	PPP1CB/PTPRF/PIK3CB/SLC27A2/GFPT1/PRKCZ/SLC27A6/AKT1/SLC2A1/RPS6KB2/PRKAB2/TNF/PPP1CC/RPS6KA1/PYGL/CREB3L4/MAPK9	1.09689215904466
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/1142	38/9376	1.51239745598673	UGP2/GFPT1/PGM2/HK1/GALK1/PGM1/HK2	1.17865061508492
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/1142	139/9376	1.24038352505386	KRT18/KRT19/CALM1/HSP90AB1/HSP90AA1/KRT23/HSPA8/GNAS/PIK3CB/MAPK3/AKT1/NRAS/ADCY5/CALM3/ITPR1/GRB2/PLCB3/ITPR3/CREB3L4/NCOA2/KRT15	1.06330997156475
NA	NA	hsa04518	Integrin signaling	23/1142	154/9376	1.22619237155139	PGF/FN1/FLT1/COL4A1/CTNNB1/COL1A1/RAC3/CDH1/COL4A2/COL9A3/PIK3CB/CCND3/FLNB/FLT4/RAC1/COL1A2/ERBB2/AKT1/ITGB4/CDC42/TGFB1/FERMT1/COL6A1	1.05399612533981
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	28/1142	193/9376	1.19111094979266	CCL3L1/RAC3/CCL4/CCR7/CXCL14/PIK3CB/CCL3/CXCL13/RAC1/PRKCZ/MAPK3/CCL2/AKT1/GNG12/CCL20/NRAS/ADCY5/CDC42/CXCL1/ELMO1/PREX1/TIAM1/CRKL/GRB2/PLCB3/CCL4L2/VAV3/BRAF	0.999045325380681
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	20/1142	133/9376	1.23461016815243	CCNB1/SKP2/CCNB2/PLK2/PIK3CB/BNIP3/PLK1/MAPK3/ATG12/AKT1/NRAS/PRKAB2/FOXO4/CDK2/MDM2/TGFB1/EP300/GRB2/BRAF/MAPK9	1.01479760497747
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1142	60/9376	1.36835960303561	RAC3/PIK3CB/RAC1/PPP3R1/MAPK3/AKT1/NRAS/CASP9/CDC42/PPP3CA	1.06597284233803
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/1142	89/9376	1.29148546803361	TUBA1C/TUBA1B/TUBB4B/GNAS/CDK1/MAPK3/TUBB/NRAS/ADCY5/ITPR1/GRB2/PLCB3/ITPR3/ADRB1	1.02893383195571
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1142	39/9376	1.47361803403835	GCSH/TYMS/GLDC/GART/SHMT1/DHFR/MAT2A	1.10374846770925
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	18/1142	119/9376	1.24187258090627	PIK3CB/TNFAIP3/CASP3/MAPK3/CCL2/AKT1/FRMD8/CCL20/ADAM17/RPS6KA4/MAP3K8/TNF/CXCL1/DNM1L/TRAF2/MAP2K6/CREB3L4/MAPK9	0.988867825100945
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	35/1142	248/9376	1.15869159934467	S100A10/TUBA1C/TUBA1B/GAPDH/HSP90AB1/HSP90AA1/RPS3/PFN1/CTNNB1/TUBB4B/ARPC3/PIK3CB/CASP4/RAC1/CASP3/BAK1/ARPC1B/MAPK3/GSDMD/TUBB/AKT1/DCTN5/VPS33A/FBXO22/ARPC5L/TXN2/CDC42/TNF/ELMO1/TRAF2/MAP2K6/ARF6/CYFIP2/MAPK9/TNFRSF10B	0.943203102563369
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1142	187/9376	1.18542382722871	HSP90AB1/HSP90AA1/YWHAE/TNFAIP3/CASP4/VDAC1/MAPK3/GSDMD/CCL2/OAS3/ATG12/NEK7/TBK1/IFNAR2/TXN2/TNF/CXCL1/BRCC3/DNM1L/SUGT1/DHX33/TRAF2/IRF3/ITPR1/PLCB3/ITPR3/MAPK9	0.953817919212094
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/1142	203/9376	1.17287965974481	PGF/FN1/FLT1/COL4A1/CTNNB1/PPP1CB/COL1A1/RAC3/COL4A2/COL9A3/PIK3CB/CCND3/FLNB/FLT4/RAC1/COL1A2/MAPK3/ERBB2/AKT1/ITGB4/CDC42/PPP1CC/DIAPH1/COL6A1/CRKL/GRB2/VAV3/BRAF/MAPK9	0.927362393032055
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	13/1142	83/9376	1.28592830164792	AURKB/EZH2/CBX4/HCFC1/CBX3/HDAC1/USP45/JARID2/BCORL1/EP300/MTF2/EED/RNF2	0.974387000010826
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/1142	173/9376	1.1864389621696	SLC25A5/KPNA2/PIK3CB/CCND3/CASP3/BAK1/VDAC1/MAPK3/CCL2/OAS3/APAF1/AKT1/RAB11A/NUP98/CASP9/TBK1/IFNAR2/TNF/PABPN1/CPSF4/XPO1/EP300/IRF3/NXF1/TNFRSF10B	0.921739663554857
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/1142	69/9376	1.30886570725145	RAC3/PIK3CB/RAC1/MAPK3/AKT1/NRAS/TNF/MAP2K6/GRB2/VAV3/MAPK9	0.958964740855792
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1142	69/9376	1.30886570725145	CALM1/GNAS/PPP3R1/ADCY5/CALM3/ORAI1/ITPR1/PLCB3/ITPR3/PPP3CA/ADRB1	0.958964740855792
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1142	136/9376	1.20737612032554	CCNE1/HSPA8/PIK3CB/TNFAIP3/CCND3/CASP3/BAK1/CSNK2A2/OAS3/APAF1/AKT1/CASP9/TBK1/IFNAR2/CDK2/EIF3H/IL2RB/CCNE2/IRF3/MAPK9	0.907205078382586
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1142	62/9376	1.32421897067962	HSPA8/SOD1/PIK3CB/CLPB/AKT1/HDAC1/NRAS/RPS6KB2/ADCY5/PRKAB2	0.953848518368356
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/1142	77/9376	1.27950508335797	PIK3CB/BAK1/MAPK3/AKT1/HDAC1/NRAS/CTBP1/MDM2/TGFB1/CRKL/GRB2/BRAF	0.91712853990113
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1142	48/9376	1.36835960303561	CLDN7/CLDN4/CLDN19/CLDN6/CD9/DPP4/CLDN3/EPCAM	0.952821624688636
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/1142	122/9376	1.21133473055611	LEP/PPARG/SCD/CCNA2/PIK3CB/PFKP/RAB8A/ADIPOR2/AKT1/PPP2R5A/RPS6KB2/PRKAB2/STRADB/TSC1/PPP2R1B/PFKFB4/EEF2K/CREB3L4	0.874982367045915
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1142	41/9376	1.40173422749989	CDH1/MAPK3/FGFR3/ERBB2/NRAS/MDM2/BRAF	0.960034545858358
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	49/1142	362/9376	1.11131967760351	CCNE1/PGF/HSP90AB1/HSP90AA1/RPS6/FN1/FLT1/EFNA1/COL4A1/IGF2/YWHAE/COL1A1/COL4A2/COL9A3/PIK3CB/CCND3/FLT4/RAC1/YWHAZ/COL1A2/ERBB3/MAPK3/FGFR3/ERBB2/RXRA/AKT1/GNG12/PPP2R5A/THEM4/NRAS/RPS6KB2/CASP9/ITGB4/IFNAR2/TSC1/CDK2/ANGPT4/PPP2R1B/MLST8/IL2RB/CDC37/MDM2/CCNE2/YWHAB/COL6A1/NGFR/GRB2/EFNA4/CREB3L4	0.804416012771989
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1142	14/9376	1.75931948961721	B4GALT1/B3GNT2/B3GNT7	1.05880871041438
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1142	49/9376	1.34043389685121	B4GALT1/GALNT1/GXYLT1/GALNT13/COLGALT1/GALNT3/XXYLT1/C1GALT1	0.889760468748281
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/1142	71/9376	1.27199625070916	F11R/ATP6V1C2/ATP6V1B1/RAC1/CASP3/ADAM17/CDC42/CXCL1/ATP6V1A/ATP6V1E1/MAPK9	0.856736287512085
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1142	21/9376	1.56383954632641	CSGALNACT1/XYLT2/DSEL/B4GALT7	0.963288871829805
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1142	28/9376	1.46609957468101	AKR1B1/GGH/GCH1/PCBD2/DHFR	0.919838597813537
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1142	28/9376	1.46609957468101	CA2/ATP6V1C2/ATP6V1B1/ATP6V1A/ATP6V1E1	0.919838597813537
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	25/1142	180/9376	1.14029966919634	HLA-G/CALR/PPP1CB/SRSF3/PIK3CB/CASP3/BAK1/CCL2/OAS3/APAF1/HCFC1/AKT1/CASP9/TBK1/IFNAR2/TSC1/TNF/PPP1CC/TRAF2/SRSF9/IRF3/SRPK1/NXF1/SRSF6/POU2F1	0.707793674582048
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1142	15/9376	1.64203152364273	AK5/NFS1/AK2	0.926731911803744
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/1142	59/9376	1.25239692481225	RRM2/TYMS/TK1/UCKL1/UMPS/RRM1/HDDC2/DHODH/UCK2	0.724244617210584
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1142	52/9376	1.26310117203287	CGA/HSD3B1/GNAS/CYP19A1/CYP11A1/HSD17B1/ADCY5/CYP2J2	0.708494659478755
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	32/1142	238/9376	1.10388673858335	PGF/CALM1/FLT1/RALBP1/EFNA1/PLA2G2A/IGF2/RAC3/PIK3CB/FLT4/RAC1/PLA2G10/RGL2/MAPK3/FGFR3/PLA2G12A/AKT1/GNG12/NRAS/FOXO4/TBK1/ANGPT4/CALM3/CDC42/RASGRF2/TIAM1/NGFR/PLD2/ARF6/GRB2/EFNA4/MAPK9	0.604555633904057
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/1142	75/9376	1.20415645067134	CGA/GPX3/GNAS/ADCY5/GSR/LRP2/ITPR1/PLCB3/ITPR3/ATP1A4/CREB3L4	0.661061972400753
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	23/1142	169/9376	1.117358729106	UBA52/RPS27A/HMGB1/VAMP8/UBB/PIK3CB/SNAP29/BNIP3/RAB8A/MAPK3/ATG12/AKT1/VPS33A/NRAS/RPS6KB2/ATG4C/GORASP1/TBK1/TSC1/MLST8/ATG10/ITPR1/MAPK9	0.57334091789256
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/1142	99/9376	1.16103239045446	CALM1/PPP1CB/GNAS/IL1RAP/PIK3CB/ADCY5/CYP2J2/CALM3/PPP1CC/MAP2K6/ITPR1/PLCB3/ITPR3/MAPK9	0.599846760422191
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/1142	76/9376	1.18831228684671	EZR/CALM1/CA2/GNAS/GAST/ADCY5/CALM3/ITPR1/PLCB3/ITPR3/ATP1A4	0.613842901654779
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/1142	178/9376	1.10698754402881	NOTUM/CTNNB1/RAC3/FRZB/WNT7A/CCND3/RAC1/RBX1/CSNK2A2/CACYBP/PPP3R1/CUL1/TLE3/RUVBL1/DVL3/CTBP1/SENP2/RNF43/SFRP1/EP300/PLCB3/PPP3CA/PRICKLE3/MAPK9	0.536673035804341
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/1142	100/9376	1.14942206654991	CCL3L1/CCL4/CCR7/CXCL14/CCL3/CXCL13/CCL2/CCL20/IL2RB/TNF/CXCL1/IL10RA/CCL4L2/TNFRSF10B	0.55943241555682
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1142	70/9376	1.17287965974481	LEP/ADIPOR2/RXRA/AKT1/SLC2A1/PRKAB2/TNF/TRAF2/ACSL4/MAPK9	0.5406605151131
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/1142	109/9376	1.12983820434133	CCL3L1/CCL4/PIK3CB/CCL3/RAC1/MAPK3/AKT1/TBK1/IFNAR2/MAP3K8/TNF/IRF3/MAP2K6/CCL4L2/MAPK9	0.507761100832896
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1142	10/9376	1.64203152364273	SUOX/BPNT1	0.756471436983648
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1142	86/9376	1.14560338858795	PIK3CB/ERBB3/MAPK3/ERBB2/AKT1/NRAS/RPS6KB2/CRKL/GRB2/NRG4/BRAF/MAPK9	0.505156690994545
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/1142	134/9376	1.10285699349139	CALM1/PLA2G2A/PPP1CB/GNAS/PLA2G10/MAPK3/PLA2G12A/ADM/ADCY5/CALM3/ACTG2/PPP1CC/CALCRL/ITPR1/PLCB3/ITPR3/BRAF/MYH10	0.4465977201143
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	23/1142	174/9376	1.08525071964893	HSP90AB1/HSP90AA1/CALR/HSPA8/DNAJA1/TUSC3/NSFL1C/CAPN1/MOGS/BAK1/RBX1/EDEM2/ERP29/CUL1/STT3A/SEC24A/MAN1A2/UBE4B/TRAF2/CKAP4/P4HB/EDEM1/MAPK9	0.422712238947118
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/1142	56/9376	1.17287965974481	B4GALT1/TUSC3/MOGS/DPM1/ALG3/STT3A/MAN1A2/ALG8	0.483218124354327
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	14/1142	103/9376	1.11594375393195	COL3A1/COL4A1/COL1A1/COL4A2/COL9A3/COL27A1/COL21A1/DPP4/COL1A2/SLC6A19/COL6A1/ATP1A4/SLC36A1/KCNN4	0.440624963925008
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/1142	103/9376	1.11594375393195	CALR/GNAS/CCL3L1/PIK3CB/CCL3/MAPK3/CCL2/AKT1/NOS2/PPP2R1B/TNF/TGFB1/PLCB3/MAPK9	0.440624963925008
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/1142	80/9376	1.12889667250438	RPS6/PIK3CB/ERBB3/MAPK3/FGFR3/ERBB2/AKT1/NRAS/RPS6KB2/GRB2/BRAF	0.431173340857722
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/1142	120/9376	1.09468768242849	CALM1/YWHAE/PIK3CB/ARHGDIB/RAC1/MAPK3/AKT1/NRAS/CALM3/CDC42/CRKL/RPS6KA1/NGFR/GRB2/BRAF/MAPK9	0.388763690135475
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1142	65/9376	1.13679105482958	HSD3B1/GNAS/CYP11A1/ADCY5/ORAI1/ITPR1/PLCB3/ITPR3/CREB3L4	0.412125486040689
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/1142	73/9376	1.12467912578269	RAN/NELFCD/PPIA/FURIN/PSIP1/CCNT1/XPO1/NUP153/EP300/SUPT5H	0.398251047577411
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/1142	73/9376	1.12467912578269	PIK3CB/BAK1/MAPK3/ERBB2/RXRA/AKT1/NRAS/CASP9/GRB2/BRAF	0.398251047577411
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/1142	105/9376	1.09468768242849	UBA52/RPS27A/TOMM20/UBB/BNIP3/CSNK2A2/TOMM7/NRAS/TOMM40/TBK1/TFEB/BCL2L13/TRAF2/MAPK9	0.363360826506758
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	14/1142	105/9376	1.09468768242849	CALM1/PIK3CB/PPP3R1/MAPK3/AKT1/NRAS/CALM3/TNF/MDM2/ITPR1/ITPR3/PPP3CA/EGR2/MAPK9	0.363360826506758
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1142	42/9376	1.17287965974481	ACAT2/KMO/DHTKD1/HADH/EHHADH/ALDH1B1	0.418165216529605
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/1142	82/9376	1.10136260732134	HLA-G/HSP90AB1/HSP90AA1/CALR/HSPA8/NFYC/HSPA2/HSPA4/NFYB/TNF/PSME2	0.343318039778716
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/1142	154/9376	1.06625423613164	CALM1/TPM1/PPP1CB/GNAS/MYL4/MAPK3/AKT1/PPP2R5A/TNNC1/TPM3/ADCY5/TNNT2/CALM3/PPP2R1B/PPP1CC/MYL3/PLCB3/ADRB1/ATP1A4/CREB3L4	0.308727070197574
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/1142	98/9376	1.08910254119161	ARPC3/PIK3CB/RAC1/ARPC1B/MAPK3/AKT1/RPS6KB2/ARPC5L/CDC42/CRKL/PLD2/ARF6/VAV3	0.330209225684032
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1142	98/9376	1.08910254119161	CALM1/HSD3B1/GNAS/CYP11A1/ADCY5/PRKD3/CALM3/ORAI1/ITPR1/PLCB3/ITPR3/ATP1A4/CREB3L4	0.330209225684032
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1142	27/9376	1.21631964714276	HMGCS1/ACAT2/HADH/EHHADH	0.419187696108715
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/1142	155/9376	1.0593751765437	CCNE1/CTNNB1/HSD3B1/GNAS/CYP11A1/WNT7A/MAPK3/ARNT/ADCY5/DVL3/FH/CDK2/ORAI1/CCNE2/ASH2L/ITPR1/PLCB3/ITPR3/CREB3L4/BRAF	0.277584371459374
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1142	51/9376	1.1268843789705	PLA2G2A/PLA2G10/PLA2G12A/GDPD3/LPCAT4/PAFAH1B3/PLD2	0.338362390865892
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1142	51/9376	1.1268843789705	GNAS/ATP6V1C2/ATP6V1B1/KDELR2/KDELR3/ATP6V1A/ATP6V1E1	0.338362390865892
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/1142	115/9376	1.07089012411483	GCM1/NACA/GATA3/MMP15/GNAS/MAPK3/RXRA/ADCY5/PLD2/ITPR1/PLCB3/ITPR3/PTH1R/CREB3L4/BRAF	0.284851803592303
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/1142	99/9376	1.078101505422	GNAS/PIK3CB/MAPK3/ERBB2/AKT1/NRAS/RPS6KB2/ADCY5/CARM1/MDM2/GRB2/BRAF/MAPK9	0.290928644102381
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1142	83/9376	1.08809317831747	CCL4/CASP3/GSDMD/DDX41/TBK1/POLR2F/ZCCHC3/POLR3K/IRF3/CCL4L2/G3BP1	0.300204097486916
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/1142	116/9376	1.06165831270004	EZR/CLDN7/CLDN4/CTNNB1/F11R/CDH5/CLDN19/PIK3CB/CLDN6/RAC1/CLDN3/CDC42/CTNND1/NCF4/VAV3	0.248844700371439
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1142	20/9376	1.23152364273205	UGP2/CMAS/GMDS	0.385992171831933
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/1142	76/9376	1.08028389713338	CALM1/PIK3CB/BAK1/MAPK3/AKT1/NRAS/CALM3/MDM2/GRB2/BRAF	0.261701990867015
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/1142	68/9376	1.08663850829298	CCNA2/PIK3CB/JUP/MAPK3/AKT1/NRAS/RPS6KB2/GRB2/BRAF	0.267024120956861
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1142	28/9376	1.17287965974481	B4GALT1/B3GNT2/ST3GAL4/ST3GAL6	0.341174702678021
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1142	60/9376	1.09468768242849	GNAS/MAPK3/NRAS/PPP2R1B/ITPR1/PLCB3/ITPR3/BRAF	0.274010768664387
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1142	44/9376	1.11956694793823	GNAS/ARHGDIB/NSF/DCTN5/RAB11A/CREB3L4	0.296048848090915
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/1142	157/9376	1.0458799513648	CTNNB1/BIRC5/PPP1CB/YWHAE/ID1/CDH1/WNT7A/BMP7/CCND3/YWHAZ/PRKCZ/RASSF6/TEAD3/DVL3/PARD6B/PPP2R1B/PPP1CC/STK3/TGFB1/YWHAB	0.215895766528508
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/1142	125/9376	1.05090017513135	RAC3/PIK3CB/RAC1/PRKCZ/CERS5/MAPK3/AKT1/PPP2R5A/NRAS/PPP2R1B/TNF/SMPD2/TRAF2/PLD2/PLCB3/MAPK9	0.213350272285736
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1142	150/9376	1.03995329830706	CCNE1/CTNNB1/CDH1/WNT7A/PIK3CB/JUP/BAK1/MAPK3/ERBB2/RXRA/AKT1/NRAS/RPS6KB2/DVL3/CDK2/CCNE2/TGFB1/GRB2/BRAF	0.183698157831199
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/1142	142/9376	1.04072420512568	PPARG/FOSB/PIK3CB/RAC1/PPP3R1/MAPK3/AKT1/IFNAR2/TNF/TRAF2/TGFB1/MAP2K6/ITPR1/GRB2/ITPR3/PPP3CA/NCF4/MAPK9	0.182102166292859
Organismal Systems	Immune system	hsa04611	Platelet activation	16/1142	126/9376	1.04255969755094	COL3A1/VAMP8/PPP1CB/COL1A1/GNAS/PIK3CB/PRKCZ/COL1A2/MAPK3/AKT1/ADCY5/ORAI1/PPP1CC/ITPR1/PLCB3/ITPR3	0.17911262468642
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	23/1142	183/9376	1.03187773343669	RAN/POP5/IMP4/EMG1/UTP18/NHP2/CSNK2A2/RPP30/RPP25L/RBM28/PWP2/WDR43/NVL/TCOF1/UTP6/RPP38/REXO1/XPO1/RCL1/SNORD3A/NXF1/NOP58/GNL3	0.162180116609597
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1142	37/9376	1.10948075921806	GPT2/GFPT1/GOT1/NIT2/GOT2	0.248485890447886
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1142	37/9376	1.10948075921806	HBA2/HBA1/HBB/TNF/PLCB3	0.248485890447886
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1142	102/9376	1.04639263761547	PLA2G2A/CA2/GNAS/RAC1/PLA2G10/RAB8A/PLA2G12A/RAB11A/ADCY5/ITPR1/PLCB3/ITPR3/ATP1A4	0.175440098944882
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1142	21/9376	1.17287965974481	BCAT2/PPCDC/ALDH1B1	0.295355395844281
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1142	13/9376	1.26310117203287	XRCC4/DCLRE1C	0.353508781059073
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1142	62/9376	1.0593751765437	NCSTN/TLE3/ADAM17/HDAC1/HEY1/DVL3/CTBP1/EP300	0.174681093013616
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/1142	95/9376	1.03707254124804	FLT1/CCL3L1/ATP6V1C2/ATP6V1B1/CCL3/CCL2/CCL20/TNF/CXCL1/ATP6V1A/TGFB1/ATP6V1E1	0.135247744811149
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1142	38/9376	1.08028389713338	PIK3CB/MAPK3/HSD11B2/SFN/ATP1A4	0.184674345338904
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1142	30/9376	1.09468768242849	PLA2G2A/PLA2G10/PLA2G12A/CYP2J2	0.193443652962434
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	21/1142	170/9376	1.01419594107345	MGST3/GSTP1/CTNNB1/IGF2/WNT7A/PIK3CB/BAK1/GSTA3/MAPK3/AKT1/GSTM4/SMARCA2/NRAS/RPS6KB2/ARID1A/DVL3/HMOX1/TGFB1/GRB2/SMARCD2/BRAF	0.0695610969741821
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1142	22/9376	1.11956694793823	CNDP2/ALDH3B2/ALDH1B1	0.209091828271541
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/1142	122/9376	1.00944560879676	GNAS/PIK3CB/MAPK3/AKT1/NRAS/ADCY5/EP300/CRKL/MAP2K6/ITPR1/GRB2/PLCB3/ITPR3/CREB3L4/MAPK9	0.0391073493761862
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/1142	89/9376	1.01473858202641	FN1/COL4A1/COL1A1/HMMR/SDC4/COL4A2/COL9A3/COL1A2/SDC1/ITGB4/COL6A1	0.0520266954792967
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1142	48/9376	1.02626970227671	PIK3CB/AKT1/HK1/PLCB3/ATP1A4/HK2	0.0679508290189994
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1142	23/9376	1.07089012411483	CA2/CA4/ATP1A4	0.126761522391796
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/1142	90/9376	1.00346370889278	PPARG/PIK3CB/ADIPOR2/AKT1/NRAS/RPS6KB2/ADCY5/PRKAB2/TSC1/SESN2/CREB3L4	0.0122959349947757
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/1142	140/9376	0.996947710783087	CALM1/RPS6/CDH1/MYL4/MAPK3/AKT1/GNG12/NRAS/RPS6KB2/ADCY5/NOS2/PRKAB2/CALM3/MYL3/ITPR1/PLCB3/ITPR3	-0.0135506771119636
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/1142	157/9376	0.993585953796558	CALR/PPARG/RAC1/ARG2/CASP3/MAPK3/RXRA/VPS33A/SLC2A1/ADAM17/ARNT/ANO6/ODC1/ELMO1/DUSP5/TGFB1/CRKL/TMEM30B/SLC16A1	-0.0301823646374648
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	28/1142	232/9376	0.990881091853373	EZR/FN1/PFN1/PPP1CB/RAC3/DIAPH3/ARPC3/PIK3CB/RAC1/ARPC1B/MAPK3/FGFR3/AKT1/GNG12/NRAS/ARPC5L/ITGB4/CDC42/PPP1CC/DIAPH1/IQGAP3/TIAM1/CRKL/CYFIP2/SPATA13/VAV3/BRAF/MYH10	-0.0523759584906735
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1142	32/9376	1.02626970227671	ATG12/ATG4C/MLST8/ATG10	0.0554340978266776
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	16/1142	133/9376	0.987688134521944	CALM1/PPP1CB/GNAS/AKT1/GNG12/PPP2R5A/ADCY5/CALM3/PPP2R1B/PPP1CC/ITPR1/PLCB3/ITPR3/PPP3CA/CREB3L4/MAPK9	-0.0532545187547806
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/1142	217/9376	0.983705521076291	MGST3/HSP90AB1/HSP90AA1/BIRC5/GNAS/KPNA2/KLF5/PIK3CB/CCND3/CDC6/GSTA3/MAPK3/RXRA/AKT1/GSTM4/ARNT/NRAS/RPS6KB2/ADCY5/PAQR7/CDC25A/RPS6KA1/GRB2/ADRB1/CREB3L4/EPHX1	-0.0904397957975479
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1142	24/9376	1.02626970227671	EXTL2/XYLT2/B4GALT7	0.0479867990546724
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/1142	101/9376	0.97546427147093	CALM1/CTNNB1/GNAS/WNT7A/MAPK3/NRAS/ADCY5/DVL3/CALM3/EP300/PLCB3/CREB3L4	-0.0923242831793648
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/1142	33/9376	0.995170620389535	VAMP8/SNAP29/BET1/VTI1B	-0.0103494768762407
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/1142	42/9376	0.977399716454007	NCOA4/SLC39A8/CP/HMOX1/ACSL4	-0.0546660750986601
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1142	43/9376	0.95466949048996	PLA2G2A/PLA2G10/PLA2G12A/ACAT2/GOT2	-0.110950037718099
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1142	26/9376	0.947325879024653	SLC19A1/SLC5A6/SLC46A1	-0.100159333109887
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1142	17/9376	0.965900896260431	CA2/CA4	-0.0524041836589116
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1142	44/9376	0.932972456615189	B4GALT1/TUSC3/ALG3/STT3A/MAN1A2	-0.165960805654161
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/1142	122/9376	0.942149234876977	PIK3CB/PPP3R1/MAPK3/AKT1/PPP2R5A/NRAS/MAP3K8/PPP2R1B/CDC42/TNF/GRB2/PPP3CA/VAV3/MAPK9	-0.239517656513724
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1142	53/9376	0.929451805835509	GNAS/CLTA/RAB11A/PLCB3/ATP1A4/PTH1R	-0.19180470356475
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/1142	71/9376	0.925088182333934	CGA/PIK3CB/MAPK3/AKT1/NRAS/ELF5/GRB2/MAPK9	-0.235957931003373
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1142	36/9376	0.912239735357073	GALNT1/GALNT13/GALNT3/C1GALT1	-0.196466720269867
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1142	45/9376	0.912239735357073	ABCA7/ABCG2/ABCC8/ABCD1/ABCB10	-0.219762377670158
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1142	18/9376	0.912239735357073	PRDX1/HCFC1	-0.138789277561374
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/1142	72/9376	0.912239735357073	ISG15/ATG12/TBK1/TNF/TRAF2/IRF3/DDX3X/MAPK9	-0.278382916453456
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	15/1142	133/9376	0.925957626114323	HLA-G/RAC3/PIK3CB/RAC1/CASP3/PPP3R1/MAPK3/NRAS/IFNAR2/TNF/GRB2/PPP3CA/VAV3/BRAF/TNFRSF10B	-0.320267549687843
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/1142	116/9376	0.920103871006703	GNAS/PPP3R1/MAPK3/SLC38A1/GNG12/ADCY5/GRIN2D/PLD2/ITPR1/PLCB3/ITPR3/PPP3CA/SHANK2	-0.322450086769259
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/1142	90/9376	0.912239735357073	PIK3CB/CSNK2A2/PPP3R1/MAPK3/AKT1/NRAS/RPS6KB2/CD274/MAP2K6/PPP3CA	-0.311543072058649
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1142	37/9376	0.88758460737445	MIF/GOT1/ALDH3B2/GOT2	-0.255146558501396
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/1142	73/9376	0.899743300626154	CDH1/PIK3CB/BAK1/MAPK3/AKT1/NRAS/MDM2/BRAF	-0.320240740393689
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/1142	91/9376	0.902215122880622	RAC3/PIK3CB/RAC1/PPP3R1/MAPK3/AKT1/NRAS/GRB2/PPP3CA/VAV3	-0.34907174359998
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/1142	109/9376	0.903870563473063	HSP90AB1/HSP90AA1/GATA3/EBI3/IL1RAP/PPP3R1/MAPK3/RXRA/IL2RB/TGFB1/PPP3CA/MAPK9	-0.375935486484744
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/1142	144/9376	0.912239735357073	CTNNB1/DUSP9/ID3/ID1/WNT7A/PIK3CB/LIFR/MAPK3/FGFR3/DLX5/AKT1/NRAS/DVL3/JARID2/SETDB1/GRB2	-0.395225111962023
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1142	144/9376	0.912239735357073	CTNNB1/SCD/CASP3/ADIPOR2/ACOX1/AKT1/PRKAB2/TBK1/TNF/CXCL1/TRA2B/ACOX3/IRF3/MAP2K6/MAPK9/ALDH1B1	-0.395225111962023
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1142	29/9376	0.849326650160034	RASSF6/TEAD3/STK3	-0.302630419769145
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1142	93/9376	0.882812647119748	CALM1/GNAS/ADCY5/CALM3/ITPR1/PLCB3/ITPR3/ADRB1/ATP1A4/KCNN4	-0.422952213400879
NA	NA	hsa04519	Cadherin signaling	46/1142	404/9376	0.934819926826308	KRT18/KRT8/KRT7/KRT19/DSP/DSC2/KRT23/CTNNB1/DSG2/PPP1CB/YWHAE/RAC3/PKP3/CDH5/CDH1/ARPC3/PKP2/WNT7A/NCSTN/JUP/FLT4/RAC1/YWHAZ/ARPC1B/MAPK3/DSC3/ERBB2/TEAD3/MYO1B/TAOK3/NRAS/DVL3/ARPC5L/CDC42/CTNND1/FAT2/PPP1CC/STK3/PCDH10/YWHAB/EP300/CYFIP2/VAV3/PRICKLE3/MAPK9/KRT15	-0.498739944487336
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1142	30/9376	0.821015761821366	PIGK/PIGS/PIGA	-0.3656585943174
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/1142	191/9376	0.902687486819303	CALM1/PPP1CB/GNAS/FOSB/SLC29A1/MAPK3/HDAC8/GNG12/HDAC1/NRAS/HAT1/ADCY5/CALM3/SLC29A2/PKIA/PPP1CC/GRIN2D/GRB2/CREB3L4/SLC29A3/BRAF	-0.50600994315704
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	25/1142	226/9376	0.908203276351069	CGA/CALM1/PPP1CB/GNAS/RAC3/PIK3CB/RAC1/MAPK3/ACOX1/AKT1/ADCY5/CALM3/ORAI1/ACOX3/PPP1CC/GRIN2D/TIAM1/EP300/PLD2/ADRB1/ATP1A4/CREB3L4/VAV3/BRAF/MAPK9	-0.520216487344777
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1142	49/9376	0.837771185532006	GNAS/FOSB/ADCY5/GRIN2D/CREB3L4	-0.424002390304299
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1142	86/9376	0.859202541440965	GNAS/SLC2A1/ADCY5/ABCC8/PLCB3/ITPR3/ATP1A4/CREB3L4/KCNN4	-0.488482987627452
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	11/1142	104/9376	0.868382055772599	PLA2G2A/PLA2G10/PLA2G12A/LYPLA1/DGKZ/PHOSPHO1/PEMT/LPCAT4/PCYT2/PTDSS1/PLD2	-0.50264147386123
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1142	59/9376	0.834931283208169	CGA/GNAS/PIK3CB/AKT1/ADCY5/ADRB1	-0.473659216312837
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/1142	105/9376	0.860111750479526	TPM1/GNAS/TNNC1/TPM3/ADCY5/ITGB4/TNNT2/TNF/TGFB1/MYL3/ADRB1	-0.536816496725767
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/1142	78/9376	0.842067448021914	CALM1/CASP3/MAPK3/NOS2/CALM3/TNF/IRF3/MAPK9	-0.521599831335404
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/1142	97/9376	0.846408001877697	CALM1/GNAS/MAPK3/GNG12/ADCY5/CALM3/GRIN2D/ITPR1/PLCB3/ITPR3	-0.566261622365895
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/1142	160/9376	0.872329246935201	HLA-G/CLDN7/CLDN4/PTPRF/SDC4/F11R/CDH5/CDH1/CLDN19/CLDN6/CNTNAP2/CD276/CLDN3/SDC1/CD274/PTPRS/ICOSLG	-0.606587472988712
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	12/1142	117/9376	0.842067448021914	UCHL5/CHRAC1/POLE3/RUVBL1/SMARCA2/HDAC1/ARID1A/MBD3/ING3/RUVBL2/SMARCD2/NFRKB	-0.640170711309948
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/1142	181/9376	0.86183974997823	CALM1/HSPD1/CASP3/PPP3R1/NFYC/MAPK3/APAF1/AKT1/NFYB/HSPA9/CASP9/NOS2/CALM3/TNF/TGFB1/EP300/PPP3CA/IL10RA/MAPK9	-0.698972018005355
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1142	12/9376	0.684179801517805	GGCX	-0.407674062800328
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1142	12/9376	0.684179801517805	NGFR	-0.407674062800328
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1142	63/9376	0.781919773163206	PTGDS/PLA2G2A/PLA2G10/PLA2G12A/CYP2J2/PTGR1	-0.646777677180238
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/1142	34/9376	0.724425672195323	POLR2D/POLR2F/POLR3K	-0.599475643572269
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1142	34/9376	0.724425672195323	RBX1/CUL1/PRKAB2	-0.599475643572269
NA	NA	hsa04517	IgSF CAM signaling	32/1142	299/9376	0.87867907619678	EZR/TUBA1C/TUBA1B/CTNNB1/TUBB4B/PTPRF/F11R/IL1RAP/CDH1/ARPC3/PIK3CB/RAC1/CNTNAP2/ARPC1B/MAPK3/TUBB/EPB41L3/AKT1/ARPC5L/PARD6B/CDC42/CD2AP/SLIT2/PTPRS/ARF6/GRB2/SSX2IP/VAV3/RAPGEF2/MAPK9/MYH10/ROBO1	-0.793987003865305
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	17/1142	166/9376	0.840799274154411	CALM1/SLC25A5/PPP1CB/VDAC1/PPP3R1/MAPK3/AKT1/ADCY5/CALM3/PPP1CC/ITPR1/PLCB3/ITPR3/PPP3CA/ADRB1/ATP1A4/CREB3L4	-0.770694981883425
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/1142	112/9376	0.806354766074556	HSPA8/CASP3/MAPK3/AKT1/CASP9/NOS2/TNF/TGFB1/MAP2K6/IL10RA/MAPK9	-0.767767650501399
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/1142	168/9376	0.830789758985906	HSP90AB1/HSP90AA1/HMGB1/SLC25A5/TNFAIP3/CAPN1/VDAC1/AIFM1/CHMP4C/PPIA/IFNAR2/TNF/DNM1L/TRAF2/PYGL/MAPK9/TNFRSF10B	-0.824160675378275
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1142	66/9376	0.746377965292151	HSD3B1/CYP19A1/CYP11A1/HSD17B1/HSD17B8/HSD11B2	-0.770011778649257
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1142	36/9376	0.684179801517805	AKR1B1/DCXR/UGP2	-0.707018818177372
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	26/1142	250/9376	0.853856392294221	VAMP8/CTSV/GM2A/AP1M2/ATP6V1C2/ATP6V1B1/NAGA/CLTA/SNAP29/AP1S1/SLC29A1/AP1G1/GAA/AP1B1/AP5B1/VPS33A/ROGDI/SLC38A9/LAPTM4B/TFEB/SLC29A2/MLST8/ATP6V1A/ATP6V1E1/SLC36A1/SLC29A3	-0.872213601926326
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/1142	115/9376	0.785319424350872	GNAS/CASP3/MAPK3/GNG12/NRAS/ADCY5/CYP2J2/ITPR1/PLCB3/ITPR3/BRAF	-0.862632841082857
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/1142	154/9376	0.799690677098733	CALM1/PPP1CB/GNAS/PPP3R1/MAPK3/NRAS/ADCY5/PRKAB2/CALM3/PPP1CC/EEF2K/ITPR1/PLCB3/ITPR3/PPP3CA	-0.933388021706155
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1142	38/9376	0.648170338280026	PNP/QPRT/NADK2	-0.809301924407114
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/1142	98/9376	0.753994066978806	CALM1/PIK3CB/PI4KA/DGKZ/CALM3/PLCD4/ITPR1/PLCB3/ITPR3	-0.911684757474205
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1142	79/9376	0.72748232060121	MGST3/GSTP1/GSTA3/GSTM4/AKR7A2/ALDH3B2/EPHX1	-0.905837031466276
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/1142	99/9376	0.746377965292151	TPM1/TNNC1/TPM3/PRKAB2/ITGB4/TNNT2/TNF/TGFB1/MYL3	-0.944743821176859
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/1142	70/9376	0.703727795846885	HLA-G/RAC3/RAC1/CASP3/EIF4G1/CASP9	-0.926555979735069
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	18/1142	184/9376	0.803167593086119	EFNA1/RAC3/BMP7/PIK3CB/SEMA6A/RAC1/PRKCZ/PPP3R1/MAPK3/NRAS/PARD6B/CDC42/SEMA4B/SLIT2/SEMA4C/PPP3CA/EFNA4/ROBO1	-1.00418508286185
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1142	90/9376	0.729791788285659	CA2/GNAS/ABCG2/RXRA/SLC2A1/ADCY5/ATP1A4/EPHX1	-0.9592210861655
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1142	16/9376	0.513134851138354	NAGA	-0.725845207123575
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/1142	148/9376	0.776636531452644	CTNNB1/WNT7A/PIK3CB/FLT4/BAK1/MAPK3/ERBB2/AKT1/NRAS/HEY1/RPS6KB2/DVL3/GRB2/BRAF	-1.02000539451638
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1142	29/9376	0.566217766773356	CALM1/CALM3	-0.871260242565838
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1142	17/9376	0.482950448130215	MYH10	-0.794612077897515
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/1142	52/9376	0.631550586016435	LIPG/PLTP/VDAC1/LRP2	-0.99218274125673
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1142	31/9376	0.529687588271849	SEC11A/IMMP1L	-0.976766807486763
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/1142	115/9376	0.713926749409883	PIK3CB/MAPK3/AKT1/GNG12/NRAS/ADCY5/ITPR1/PLCB3/ITPR3/CREB3L4	-1.14950400225165
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/1142	65/9376	0.631550586016435	AKR1B1/LIPG/DGKZ/GLYCTK/ALDH1B1	-1.11006815473831
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/1142	86/9376	0.668268643342972	DSP/DSC2/CTNNB1/DSG2/PKP2/JUP/ITGB4	-1.15090944004212
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	32/1142	323/9376	0.813390228429836	CCNE1/EZR/TPM1/EFNA1/STMN1/IGF2BP1/PIK3CB/EZH2/HNRNPK/TRIM71/CDCA5/CASP3/BAK1/ERBB3/MAPK3/FGFR3/ERBB2/HDAC1/NRAS/KIF23/HMOX1/MDM2/CCNE2/CDC25A/CDC25C/EP300/CRKL/GRB2/SLC7A1/DNMT1/DNMT3B/EFNA4	-1.27102075113599
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/1142	55/9376	0.597102372233721	GM2A/CERS5/SMPD4/SMPD2	-1.11598423581862
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1142	44/9376	0.559783473969113	HLA-G/HSPD1/TNF	-1.08998011314431
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/1142	250/9376	0.788175131348511	HLA-G/HSPA8/FOLR1/ARPC3/CLTA/PRKCZ/ARPC1B/RAB8A/CHMP4C/FGFR3/RAB11A/SH3GL1/RAB11FIP1/RAB11FIP4/VPS25/ARPC5L/NEDD4/PARD6B/CDC42/IL2RB/EPN3/MDM2/PLD2/ARF6	-1.26421219897652
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	29/1142	298/9376	0.798975070228846	LEP/EBI3/GDF15/CCL3L1/CCL4/IL1RAP/CCR7/CXCL14/BMP7/CCL3/CXCL13/LIFR/CCL2/CCL20/IL11RA/CSF2RB/IFNAR2/IL2RB/TNF/CXCL1/CNTFR/ACVRL1/TGFB1/INHA/NGFR/CSF2RA/IL10RA/CCL4L2/TNFRSF10B	-1.31333712435866
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/1142	78/9376	0.631550586016435	TPI1/ISYNA1/PIK3CB/PI4KA/PLCD4/PLCB3	-1.21686852889024
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/1142	168/9376	0.733049787340505	LEP/PIK3CB/CCND3/LIFR/PTPN2/AKT1/IL11RA/CSF2RB/IFNAR2/IL2RB/CNTFR/EP300/GRB2/CSF2RA/IL10RA	-1.30021602852926
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	24/1142	254/9376	0.775762924555621	CALM1/FLT1/SLC25A5/GNAS/FLT4/VDAC1/PPP3R1/ERBB3/FGFR3/ERBB2/PHKG2/TNNC1/NOS2/TFEB/CALM3/ORAI1/PLCD4/GRIN2D/ITPR1/PLCB3/ITPR3/PPP3CA/ADRB1/P2RX4	-1.34925023939787
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/1142	79/9376	0.623556274801037	ATP6V1C2/ATP6V1B1/CLTA/NSF/ATP6V1A/ATP6V1E1	-1.25128273255746
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1142	70/9376	0.586439829872404	MGST3/GSTP1/GSTA3/GSTM4/EPHX1	-1.29336010344711
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	18/1142	201/9376	0.735237995660925	FLT1/PPARG/MYCN/SPINT1/CCNA2/NFKBIZ/JUP/BAK1/LMO2/RXRA/HDAC1/ETV4/IL2RB/CCNT1/MDM2/NGFR/TAF15/MLF1	-1.41307076462533
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/1142	155/9376	0.688593864753404	HLA-G/TUBA1C/TUBA1B/CALR/TUBB4B/ATP6V1C2/ATP6V1B1/RAC1/TUBB/ATP6V1A/ATP6V1E1/COLEC12/NCF4	-1.45585211451795
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1142	23/9376	0.356963374704942	B4GALT1	-1.14984001782891
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	8/1142	105/9376	0.625535818530565	CCL4/TNFAIP3/CSNK2A2/TNF/CXCL1/TRAF2/CCL4L2/PPP1R13L	-1.43699381995829
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1142	73/9376	0.562339562891347	MGST3/GSTP1/GSTA3/GSTM4/ALDH3B2	-1.39797842235034
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1142	38/9376	0.432113558853351	ORAI1/DCLRE1C	-1.30629005928012
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/1142	63/9376	0.52127984877547	CTNNB1/WNT7A/BAK1/DVL3	-1.41977799601286
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1142	39/9376	0.421033724010957	HLA-G/TNF	-1.34925846156967
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/1142	149/9376	0.661220747775597	GNAS/PIK3CB/MAPK3/DGKZ/AKT1/NRAS/ADCY5/TSC1/PLD2/ARF6/GRB2/PLCB3	-1.55236176632849
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/1142	78/9376	0.526292155013696	MAPK3/NOS2/TNF/TGFB1/NCF4	-1.56450287766766
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1142	93/9376	0.529687588271849	GATA3/PPP3R1/MAPK3/IL2RB/PPP3CA/MAPK9	-1.69745002887465
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1142	45/9376	0.364895894142829	HLA-G/TNF	-1.590377934013
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1142	31/9376	0.264843794135925	ALDH1B1	-1.52680678268171
Human Diseases	Immune disease	hsa05310	Asthma	1/1142	32/9376	0.256567425569177	TNF	-1.56878496849497
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1142	50/9376	0.328406304728546	TGFB1/ICOSLG	-1.77319772685893
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/1142	66/9376	0.373188982646075	GATA3/TNF/TGFB1	-1.90303601540623
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/1142	195/9376	0.58944721361534	HMGB1/SLC25A5/PIK3CB/CASP4/RAC1/VDAC1/MAPK3/GSDMD/HDAC8/AKT1/HDAC1/HAT1/PLCB3/NCF4	-2.15751873085393
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1142	54/9376	0.304079911785691	HLA-G/CGA	-1.90991905800853
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/1142	56/9376	0.293219914936202	CUL1/LRP2	-1.9755299584674
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1142	41/9376	0.200247746785699	GRIN2D	-1.91118838937863
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/1142	100/9376	0.410507880910683	GYPA/CD9/IL11RA/TNF/CSF2RA	-2.20704349597311
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/1142	89/9376	0.368995848009603	NSF/SLC38A1/GNG12/ADCY5	-2.22742328963232
NA	NA	hsa04081	Hormone signaling	14/1142	219/9376	0.52485025869859	CGA/LEP/DIO2/IGF2/GNAS/GAST/PIK3CB/ADIPOR2/GNG12/ADCY5/THRB/PLCB3/ADRB1/PTH1R	-2.64965424509088
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/1142	99/9376	0.331723540129845	KRT18/KRT19/KRT23/KRT15	-2.48933440277591
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/1142	91/9376	0.270664536864187	GNAS/GNG12/ADCY5	-2.60357643519159
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1142	86/9376	0.190933898097992	PLCB3/ITPR3	-2.80697557107878
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/1142	88/9376	0.186594491323038	TFPI/SERPINE2	-2.8549637665143
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1142	143/9376	0.229654758551431	SNRPB/SNRPD1/TNF/SNRPD3	-3.45696724011577
NA	NA	hsa04082	Neuroactive ligand signaling	7/1142	199/9376	0.288799514208521	GNAS/GNG12/ADCY5/GRIN2D/PLCB3/ADRB1/P2RX4	-3.77643031976136
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/1142	370/9376	0.310654612581057	CGA/LEP/KISS1/TMEM97/KISS1R/ADM/RLN2/GRIN2D/CALCRL/THRB/CHRNA5/ADRB1/PTH1R/P2RX4	-5.03831160101883
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1142	449/9376	0.0365708579875887	CALM1/CALM3	-7.7911836374534