category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	99/993	222/9376	4.21066383604148	RPSA/RPL36/RPS5/RPL29/RPL35A/RPL5/RPS9/RPLP0/RPL14/RPL6/RPL7A/RPL37A/RPL37/RPL39/RPS15/RPS4X/RPL18/RPS3/RPS7/RPL28/RPS19/RPS3A/RPL8/RPS2/RPS6/RPL19/RPL18A/RPL11/RPL15/RPS23/RPL32/RPL13/RPS18/RPL10/RPS27A/RPL3/RPL24/RPS24/RPL26/RPS13/RPLP1/RPS14/RPS8/RPS16/RPL27A/RPS27/RPL13A/RPL23A/RPL22/RPL12/RPL35/RPL4/RPS11/RPL10A/RPL7/RPL30/RPL9/RPS12/RPS28/RPS25/RPL21/RPS20/RPLP2/RPL41/RPS29/RPL31/RPL23/RPL38/RPS15A/UBA52/RPS21/RPS10/RPL27/MRPL11/RPL22L1/RPS26/MRPS15/RPL17/MRPL51/MRPL23/MRPS31/MRPS9/MRPL14/MRPL50/MRPS33/MRPL21/MRPS21/MRPL37/MRPS22/MRPL16/MRPL41/MRPS6/MRPS12/MRPS27/DAP3/MRPL4/MRPL52/MRPL35/MRPL39	16.6619719439808
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	81/993	238/9376	3.21348599862906	RPSA/RPL36/RPS5/RPL29/RPL35A/RPL5/RPS9/RPLP0/RPL14/RPL6/RPL7A/RPL37A/RPL37/RPL39/RPS15/RPS4X/RPL18/RPS3/RPS7/RPL28/RPS19/RPS3A/RPL8/RPS2/RPS6/RPL19/RPL18A/RPL11/RPL15/RPS23/RPL32/RPL13/RPS18/RPL10/RPS27A/RPL3/RPL24/RPS24/RPL26/RPS13/RPLP1/RPS14/RPS8/RPS16/RPL27A/RPS27/RPL13A/RPL23A/RPL22/RPL12/RPL35/RPL4/RPS11/RPL10A/RPL7/RPL30/RPL9/RPS12/RPS28/RPS25/RPL21/RPS20/RPLP2/RPL41/RPS29/RPL31/RPL23/RPL38/RPS15A/UBA52/RPS21/CFD/RPS10/C1R/RPL27/RPL22L1/RPS26/RPL17/C1S/JUN/PRKCA	11.9041998761723
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	61/993	158/9376	3.64536566089207	CCNE1/CCNB1/PTTG1/CDKN1C/CCNB2/CDC20/CDK1/MAD2L1/CDT1/AURKB/CCNA2/YWHAQ/CDC6/SKP2/ORC6/TTK/MCM7/CDK7/YWHAB/ANAPC11/CDCA5/CHEK1/PKMYT1/PLK1/CDK2/NDC80/MCM5/BUB1/ORC1/WEE1/TFDP1/ESCO2/MCM6/CDC45/CCND2/E2F5/CDC25C/SMC1A/TRIP13/PPP2R1A/MYC/E2F1/CHEK2/MCM3/FBXO5/DBF4/PRKDC/PCNA/PPP2R1B/BUB1B/RAD21/CDC25A/GADD45A/STAG2/PPP2R5C/TICRR/BUB3/HDAC2/DDX11/CCNE2/E2F3	11.5413452472204
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	34/993	116/9376	2.76751050456645	GAPDH/ENO1/PKM/TPI1/ACAT2/ADH5/GCSH/IDH2/PCCA/RPIA/ECHS1/GPT2/PHGDH/ALDOA/HK1/SDHA/PGK1/TKT/PRPS2/MDH2/GPI/GLDC/FH/PGLS/PGAM1/ALDOC/SUCLG1/PGP/ACAT1/PFKP/SHMT1/IDH1/PC/ESD	6.59243769826395
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	17/993	36/9376	4.45876692402372	RNASEH2A/SSBP1/RPA3/POLD2/MCM7/FEN1/MCM5/MCM6/RFC3/MCM3/LIG1/RFC4/POLA2/POLE2/PCNA/RFC5/RFC2	7.15582380931395
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	19/993	46/9376	3.89999562152459	PSMA7/PSMD11/PSMD14/PSMA4/PSMA1/PSMC4/PSMB2/PSMD3/PSMD6/PSMB3/PSMC1/ADRM1/PSMD2/PSMB7/PSMB5/PSMC2/PSMD1/PSMD12/PSMD13	6.78572047180302
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	57/993	268/9376	2.00820670063579	RPS27A/HSPA5/TUBA1B/TUBB/GNAS/UQCRH/TUBA1C/NDUFA4/UBA52/CALM3/TUBB6/PSMA7/SLC25A6/NDUFB11/COX7C/TXN2/COX6C/PSMD11/COX5A/PSMD14/PSMA4/COX5B/PSMA1/TUBB4B/PSMC4/ADCY5/COX8C/UQCRFS1/VDAC1/VDAC2/GNAI1/SLC39A4/PSMB2/SDHA/PSMD3/PSMD6/COX7A1/NDUFS2/CYC1/PSMB3/PPIF/NDUFA4L2/PSMC1/TH/COX7A2L/ADRM1/PSMD2/PSMB7/PSMB5/PSMC2/SLC39A10/GNAI3/PSMD1/NDUFS4/PSMD12/PSMD13/NDUFA3	5.76323057137229
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	46/993	203/9376	2.13958795311019	COL1A1/CAV1/ACTG1/ACTB/COL6A2/COL1A2/LAMA4/COL4A1/COL4A2/PPP1CB/COL6A3/COL6A1/ACTN1/BRAF/FYN/PPP1CA/MYL9/RAC3/LAMB1/FLNB/CDC42/CTNNB1/GRB2/IGF1/RAC1/JUN/PARVA/CAV2/VASP/LAMA1/PPP1CC/ITGA1/AKT1/VCL/PDGFRB/CCND2/PRKCA/COL9A3/FLT4/PAK3/PDGFRA/PXN/ACTN4/THBS1/RAP1B/ITGB5	5.64937886839875
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	41/993	174/9376	2.22486138602401	CALR/HSPA5/PDIA6/SSR2/OSTC/PDIA3/SSR3/HSP90B1/PDIA4/P4HB/LMAN1/HSP90AB1/SEC61B/MAN1A2/HERPUD1/SEC61G/UBXN4/DDOST/DAD1/SAR1A/VCP/ERP29/RRBP1/DNAJB11/STT3B/TMEM258/LMAN2/ERLEC1/DNAJC3/CANX/STT3A/TUSC3/SEC23B/NGLY1/TRAM1/SEC61A1/CKAP4/PRKCSH/SEC13/BAG1/EDEM2	5.61281829183628
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	59/993	308/9376	1.8087129386223	GPX3/TUBA1B/TUBB/UQCRH/TUBA1C/SLC1A2/NDUFA4/TUBB6/PSMA7/SLC25A6/TBPL1/NDUFB11/COX7C/COX6C/PSMD11/COX5A/PSMD14/PSMA4/COX5B/PSMA1/TUBB4B/GPX8/POLR2L/PPARG/PSMC4/COX8C/UQCRFS1/VDAC1/VDAC2/POLR2H/PSMB2/TFAM/SDHA/PSMD3/PSMD6/COX7A1/NDUFS2/CYC1/PSMB3/PPIF/NDUFA4L2/NRBF2/PSMC1/AP2A1/COX7A2L/ADRM1/PSMD2/PSMB7/HAP1/PSMB5/PSMC2/DCTN2/POLR2I/PSMD1/NDUFS4/PSMD12/HDAC2/PSMD13/NDUFA3	4.96677542191455
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	22/993	75/9376	2.76968110104062	GAPDH/ARG2/ENO1/PKM/TPI1/CBS/IDH2/RPIA/GPT2/PHGDH/ALDOA/PGK1/TKT/PRPS2/PGAM1/ALDOC/CTH/PFKP/SHMT1/ASL/IDH1/PC	5.29567533647378
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/993	31/9376	3.95958808433226	HSPA5/SEC11A/SEC61B/SEC61G/SPCS3/SRP19/SPCS2/SRPRB/SEC11C/SRP72/SRP9/SEC61A1/SRP68	5.68045329708953
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	11/993	23/9376	4.51578440387057	SSBP1/RPA3/POLD2/EXO1/RFC3/LIG1/RFC4/PCNA/RFC5/MSH2/RFC2	5.80993422169452
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	47/993	233/9376	1.90462853709875	COL1A1/TPM1/ENO1/ACTG1/COL3A1/TPM2/ACTB/COL6A2/COL1A2/DCN/COL4A1/TNNI2/COL4A2/MYL4/COL6A3/TPM4/COL6A1/DSC2/VCAN/LMNB1/DSP/NID1/DIAPH3/COL5A2/MYL9/COL27A1/COL5A1/SSPN/LMNB2/SPTBN1/LAMA1/MYH10/ITGA1/FBLN2/VCL/COL9A3/SDC4/LBR/MYH9/FHL2/SYNPO2/NID2/THBS1/LMOD1/ITGB5/SGCB/CAPN3	4.81242986998315
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/993	275/9376	1.81974915316305	HSPA5/TUBA1B/CAV1/TUBB/UQCRH/TUBA1C/NDUFA4/TUBB6/PSMA7/SLC25A6/NDUFB11/COX7C/COX6C/PSMD11/FYN/COX5A/PSMD14/PSMA4/COX5B/PSMA1/TUBB4B/PSMC4/COX8C/UQCRFS1/EGR1/VDAC1/VDAC2/RAC1/PSMB2/CAV2/SDHA/PSMD3/PSMD6/COX7A1/NDUFS2/CYC1/PSMB3/PPIF/NDUFA4L2/STIP1/PSMC1/COX7A2L/ADRM1/PSMD2/PSMB7/PSMB5/PSMC2/PSMD1/NDUFS4/PSMD12/PSMD13/CSNK2A1/NDUFA3	4.74857493508304
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	66/993	368/9376	1.69341915145146	GPX3/HNRNPA1/HSPA5/TUBA1B/ACTG1/TUBB/UQCRH/TUBA1C/SLC1A2/HNRNPA3/ACTB/NDUFA4/HNRNPA2B1/TUBB6/PSMA7/SRSF3/PFN1/NDUFB11/COX7C/COX6C/ALYREF/PSMD11/COX5A/PSMD14/PSMA4/COX5B/VCP/PSMA1/TUBB4B/GPX8/PSMC4/COX8C/UQCRFS1/SRSF7/MAP1LC3A/VDAC1/RAC1/PSMB2/SDHA/PSMD3/NUP37/PSMD6/COX7A1/NDUFS2/CYC1/PSMB3/HNRNPA1L2/NDUFA4L2/NRBF2/PSMC1/TOMM40/COX7A2L/ADRM1/PSMD2/PSMB7/HAP1/PSMB5/PSMC2/DCTN2/SEC13/PSMD1/NDUFS4/PSMD12/PSMD13/TNFRSF1B/NDUFA3	4.67052909825997
NA	NA	hsa04518	Integrin signaling	34/993	154/9376	2.08461830214096	COL1A1/ACTG1/ACTB/COL6A2/COL1A2/LAMA4/COL4A1/COL4A2/COL6A3/COL6A1/ACTN1/RAC3/LAMB1/FLNB/CDC42/CDH1/CTNNB1/IGF1/RAC1/PARVA/LAMA1/ITGA1/AKT1/VCL/PDGFRB/CCND2/COL9A3/FRAS1/FLT4/PDGFRA/PXN/ACTN4/THBS1/ITGB5	4.67073534052293
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/993	20/9376	4.24894259818731	SQLE/MSMO1/DHCR24/DHCR7/EBP/HSD17B7/LBR/SC5D/CYP51A1	5.00578807065465
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	14/993	44/9376	3.00430284720315	HMGB1/APEX1/PARP1/POLD2/FEN1/RFC3/NTHL1/LIG1/RFC4/POLE2/PCNA/RFC5/RFC2/UNG	4.58630408132324
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/993	85/9376	2.3327527990048	RRM2/TK1/IMPDH2/TYMS/NME1/DUT/ADA/GMPS/NME2/AK2/DTYMK/PNP/AK5/APRT/NME1-NME2/HDDC2/NT5C3B/AK4/ENPP1/ADSL/NT5C	4.24803773089838
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	32/993	157/9376	1.92450337072886	HLA-G/CCNE1/CCNB1/CCNB2/CDK1/HLA-C/CALM3/PPP1CB/SLC25A6/CCNA2/PPP1CA/IGFBP3/MYBL2/VDAC1/VDAC2/CHEK1/CDK2/PPP1CC/MAP2K2/EIF4EBP1/AKT1/CCND2/E2F5/FOXM1/MYC/E2F1/CHEK2/CDC25A/GADD45A/CCNE2/E2F3/FOXO1	4.02047112178562
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	30/993	144/9376	1.96710305471635	PSMA7/SLC25A6/TBPL1/PSMD11/PSMD14/PSMA4/PSMA1/PSMC4/VDAC1/VDAC2/PSMB2/PSMD3/PSMD6/AKT1/PSMB3/PPIF/PRKCA/NRBF2/DAB1/ATXN10/PSMC1/NOP56/ADRM1/PSMD2/PSMB7/PSMB5/PSMC2/PSMD1/PSMD12/PSMD13	4.02500693120788
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	19/993	75/9376	2.39199731453508	CCNE1/CCNB1/RRM2/CCNB2/CDK1/IGFBP3/GTSE1/CHEK1/IGF1/EI24/SIVA1/CDK2/CCND2/CHEK2/THBS1/GADD45A/SHISA5/CCNG1/CCNE2	4.16547695665986
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	63/993	388/9376	1.53312361790264	GAPDH/TUBA1B/TUBB/UQCRH/TUBA1C/NDUFA4/CALM3/TUBB6/PSMA7/SLC25A6/DKK1/BRAF/NDUFB11/COX7C/COX6C/PSMD11/HSD17B10/COX5A/PSMD14/PSMA4/COX5B/PSMA1/TUBB4B/BACE2/PSMC4/COX8C/UQCRFS1/CTNNB1/VDAC1/VDAC2/SLC39A4/APP/PSMB2/SDHA/PSMD3/MAP2K2/PSMD6/COX7A1/NDUFS2/AKT1/CYC1/PSMB3/PPIF/NDUFA4L2/NRBF2/PSMC1/COX7A2L/ADRM1/PSMD2/PSMB7/AXIN1/PSMB5/PSMC2/CSNK1E/SLC39A10/PSMD1/NDUFS4/AXIN2/PSMD12/PSMD13/CSNK2A1/LRP6/NDUFA3	3.69124424542404
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	33/993	170/9376	1.83287719921806	TUBA1B/ACTG1/TUBA1C/ACTB/CLDN10/JAM3/ACTN1/CLDN6/MYL9/CDC42/CLDN7/RAB8B/PARD3/ACTR3/RAC1/JUN/VASP/MYH10/ARPC4/MYL6B/CLDN3/PPP2R1A/CLDN19/MYH9/RAB13/ACTN4/MAGI1/PCNA/PPP2R1B/ARPC1A/CTTN/CGNL1/ACTR2	3.77164212622059
Genetic Information Processing	Transcription	hsa03040	Spliceosome	43/993	243/9376	1.67082333536401	HNRNPA1/HNRNPA3/RBM8A/SNRPD2/SNRPF/SNRPD1/SRSF9/SRSF3/SNRPB/LSM5/RBMX/HNRNPM/ALYREF/SNRPE/HNRNPU/SNRPA/U2AF1/HNRNPC/SRSF2/SNRPG/LSM7/SRSF7/HNRNPK/SRSF6/SF3B5/LSM4/EIF4A3/LSM2/THOC3/TRA2A/DDX5/SNRPD3/RBM25/HNRNPA1L2/SNRNP40/PPIH/PPIL1/PRPF38A/MAGOH/LSM6/SNRNP70/TCERG1/BCAS2	3.64640664252283
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	12/993	39/9376	2.90525989619645	TYMS/ALDH7A1/GCSH/CBS/DHFR/MTHFD1L/AHCY/GLDC/MTHFD2/CTH/MTHFD1/SHMT1	4.10339551629354
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	28/993	138/9376	1.91578732285418	CCNE1/CCNB1/PTTG1/CCNB2/CDC20/CDK1/CALM3/MAD2L1/PPP1CB/AURKA/YWHAQ/PPP1CA/ADCY5/YWHAB/ANAPC11/IGF1/PKMYT1/PLK1/CDK2/BUB1/PPP1CC/CDC25C/SMC1A/PPP2R1A/FBXO5/PPP2R1B/PPP2R5C/CCNE2	3.72997328208461
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	37/993	205/9376	1.70418293911036	COL1A1/GAPDH/MMP2/UQCRH/COL3A1/COL1A2/NDUFA4/SLC2A1/PPP1CB/SLC25A6/NDUFB11/COX7C/COX6C/PARP1/COX5A/COX5B/PPP1CA/PDK3/COX8C/UQCRFS1/VDAC1/VDAC2/GYS1/REN/RAC1/SDHA/PPP1CC/COX7A1/NDUFS2/AKT1/CYC1/PPIF/PRKCA/NDUFA4L2/COX7A2L/NDUFS4/NDUFA3	3.50844450934443
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	24/993	116/9376	1.95353682675279	MMP2/ACTG1/ACTB/CLDN10/JAM3/ACTN1/CLDN6/THY1/MYL9/CDC42/CTNNB1/CLDN7/GNAI1/RAC1/CXCL12/VASP/CLDN3/VCL/PRKCA/CLDN19/PXN/ACTN4/RAP1B/GNAI3	3.55648925826892
Cellular Processes	Cell motility	hsa04814	Motor proteins	35/993	194/9376	1.70347068655849	TPM1/TUBA1B/ACTG1/TUBB/TUBA1C/MYO10/TPM2/ACTB/TUBB6/TNNI2/MYL4/TPM4/ACTA2/DYNLL1/CENPE/TUBB4B/MYL9/KIF2C/MYO1B/KIF11/KIFC1/KIF4A/KIF23/MYH10/MYL6B/KIF20A/KIF20B/KIF14/KIF22/MYH9/KIF18A/MYO7A/KIF15/DCTN2/KIF16B	3.40752268162447
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	13/993	48/9376	2.55723397113125	ACAT2/ALDH7A1/HSD17B10/PCCA/HMGCS1/ECHS1/HMGCS2/MCCC2/ACAT1/ALDH1B1/HADH/OXCT1/ACADSB	3.72255179055058
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/993	93/9376	2.03055799196526	ACTG1/ACTB/ACTN1/FYN/MYL9/RAC3/TCF7L2/CDC42/CDH1/CTNNB1/PARD3/ACP1/RAC1/VCL/FGFR1/ACTN4/IQGAP1/SNAI2/RAP1B/CSNK2A1	3.43740151474153
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	37/993	212/9376	1.64791274772464	ACTG1/GNAS/ACTB/CALM3/BRAF/PFN1/ENAH/ID1/RAC3/ADCY5/CDC42/CDH1/CTNNB1/GNAI1/PARD3/IGF1/RAC1/VASP/EFNA1/MAP2K2/FGF7/AKT1/PDGFRB/PRKCA/FGFR1/FGFR3/SIPA1L2/FLT4/PDGFRA/MAGI1/ANGPT4/THBS1/RAP1B/EFNA3/FGF2/GNAI3/RASGRP2	3.2839946760269
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/993	50/9376	2.454944612286	ARG2/SRM/ALDH7A1/ODC1/CKB/GAMT/DAO/SAT2/P4HA1/ALDH1B1/OAT/CKMT1A/P4HA2	3.55013024623437
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	8/993	23/9376	3.2842068391786	ACAT2/HMGCR/FDPS/HMGCS1/IDI1/MVD/HMGCS2/ACAT1	3.77471709293724
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/993	57/9376	2.31911096977085	ACAT2/SCD/HSD17B12/ELOVL6/ECHS1/FADS2/ACAT1/ELOVL5/ACACA/HADH/ELOVL1/ACADSB/FADS1/FASN	3.43791102958739
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	71/993	480/9376	1.39664316884861	GPX3/RPS27A/HSPA5/TUBA1B/TUBB/UQCRH/TUBA1C/NDUFA4/UBA52/CALM3/TUBB6/PSMA7/SLC25A6/DKK1/BRAF/NDUFB11/COX7C/COX6C/PSMD11/HSD17B10/COX5A/PSMD14/PSMA4/COX5B/VCP/PSMA1/TUBB4B/GPX8/PSMC4/COX8C/UQCRFS1/MAP1LC3A/CTNNB1/VDAC1/VDAC2/APP/RAC1/PSMB2/SDHA/PSMD3/MAP2K2/PSMD6/COX7A1/NDUFS2/CYC1/PSMB3/PPIF/PRKCA/NDUFA4L2/NRBF2/PSMC1/TOMM40/COX7A2L/ADRM1/PSMD2/PSMB7/HAP1/AXIN1/PSMB5/PSMC2/DCTN2/CSNK1E/PSMD1/NDUFS4/AXIN2/PSMD12/PSMD13/CSNK2A1/TNFRSF1B/LRP6/NDUFA3	3.07032069585091
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	56/993	362/9376	1.46065552792197	CCNE1/COL1A1/RPS6/COL6A2/COL1A2/HSP90B1/HSP90AB1/LAMA4/COL4A1/COL4A2/COL6A3/COL6A1/YWHAQ/LAMB1/EIF4B/YWHAB/GRB2/GYS1/IGF1/RAC1/CDK2/EFNA1/GNB2/LAMA1/MAP2K2/GHR/FGF7/EIF4EBP1/ITGA1/AKT1/BRCA1/PDGFRB/CCND2/PRKCA/COL9A3/FGFR1/PPP2R1A/MYC/FGFR3/FLT4/PDGFRA/CDC37/MAGI1/SGK2/PPP2R1B/ANGPT4/THBS1/EFNA3/FGF2/PPP2R5C/GNG4/GNG7/GNB5/CCNE2/ITGB5/GNB1	3.07632577959317
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/993	71/9376	2.12779598031289	LDHA/PKM/SLC2A1/SLC16A3/IDH2/HK1/MAP2K2/AKT1/PDGFRB/PGAM1/FGFR1/MYC/FGFR3/PDGFRA/PFKP/IDH1	3.28293328613307
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	17/993	78/9376	2.05789242647249	ENO1/HSPD1/LSM5/PABPC1/DHX36/LSM7/PABPC4/EXOSC8/LSM4/LSM2/PNPT1/EXOSC3/PFKP/LSM6/DCPS/EXOSC5/TOB2	3.22889979771263
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/993	41/9376	2.53324490948837	ALDH7A1/ALAS2/GCSH/CBS/PHGDH/GAMT/DAO/GLDC/PGAM1/CTH/SHMT1	3.38615495440677
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/993	47/9376	2.41074757343961	LDHA/PKM/ACAT2/ALDH7A1/ADH5/GLO1/MDH2/FH/ACAT1/ALDH1B1/ACACA/PC	3.33688487730122
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	21/993	106/9376	1.87060365957932	CCNE1/SLC19A1/HSP90B1/HSP90AB1/BRAF/TCF7L2/CTNNB1/GRB2/IGF1/ETV5/CDK2/ZEB1/MAP2K2/AKT1/PDGFRB/FGFR1/E2F1/PDGFRA/CCNE2/E2F3/FOXO1	3.10237350882516
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/993	67/9376	2.11390179014294	GAPDH/LDHA/ENO1/PKM/TPI1/ALDH7A1/ADH5/ALDOA/HK1/PGK1/GPI/PGAM1/ALDOC/PFKP/ALDH1B1	3.1491497829252
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	34/993	204/9376	1.57368244377308	COL1A1/RPS6/CAV1/MMP2/ACTG1/ACTB/LUM/COL1A2/DCN/PPP1CB/BRAF/PPP1CA/CDC42/EIF4B/CTNNB1/GPC1/GRB2/IGF1/RAC1/CAV2/PPP1CC/MAP2K2/DDX5/AKT1/PRKCA/SDC4/FGFR1/MYC/PXN/IQGAP1/THBS1/FGF2/CTTN/ITGB5	2.85111772172556
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/993	44/9376	2.36052366565962	OSTC/MAN1A2/DDOST/DAD1/STT3B/TMEM258/B4GALT1/STT3A/TUSC3/ALG9/MGAT1	3.11318983019891
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	21/993	110/9376	1.80258170832189	CCNB1/CCNB2/CDK1/MAD2L1/HSP90AB1/AURKA/CCNA2/BRAF/ADCY5/ANAPC11/GNAI1/IGF1/PKMYT1/PLK1/CDK2/BUB1/AKT1/CDC25C/KIF22/CDC25A/GNAI3	2.91407001062469
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/993	27/9376	2.79765767781881	ACAT2/HMGCS1/ECHS1/ACSM3/HMGCS2/ACAT1/HADH/OXCT1	3.21933985050839
NA	NA	hsa04517	IgSF CAM signaling	46/993	299/9376	1.45262994809823	TUBA1B/ACTG1/TUBB/TUBA1C/ACTB/TUBB6/JAM3/ACTN1/DYNLL1/FYN/MTSS1/TUBB4B/MYL9/CDC42/CDH1/CTNNB1/PTPRS/GRB2/PARD3/ACTR3/APP/RAC1/CNTNAP2/SPTBN1/MAP2K2/MYH10/ARPC4/MYL6B/AKT1/ROBO1/CLMP/VCL/PRKCA/FGFR1/MYH9/PAK3/ERC1/PXN/ACTN4/IQGAP1/MAGI1/RAP1B/ARPC1A/SRGAP1/FOXO1/ACTR2	2.73758896324256
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/993	51/9376	2.22166933238552	ACTG1/GNAS/ACTB/KDELR2/KDELR1/PDIA4/SEC61B/SEC61G/PRKCA/ATP6V1B1/ATP6V0A4/SEC61A1	3.01075120662853
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	37/993	232/9376	1.50585130395527	ACTG1/ACTB/PPP1CB/ACTN1/BRAF/PFN1/DIAPH3/ENAH/PPP1CA/MYL9/RAC3/CDC42/ACTR3/RAC1/CXCL12/PPP1CC/MAP2K2/MYH10/ARPC4/FGF7/ITGA1/AKT1/VCL/PDGFRB/FGFR1/GNA12/FGFR3/MYH9/PAK3/PDGFRA/PXN/ACTN4/IQGAP1/FGF2/ARPC1A/ITGB5/ACTR2	2.68509271914896
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/993	59/9376	2.08046153583559	RRM2/TK1/TYMS/NME1/UMPS/DUT/NME2/DTYMK/NME1-NME2/HDDC2/NT5C3B/ENPP1/NT5C	2.86521884000504
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	19/993	103/9376	1.74174561737991	COL1A1/COL3A1/COL6A2/COL1A2/COL4A1/COL4A2/COL6A3/COL6A1/COL5A2/COL18A1/COL27A1/COL5A1/COL21A1/FXYD2/COL14A1/DPP4/COL9A3/SLC6A19/COL15A1	2.60509761200421
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	32/993	200/9376	1.51073514602216	GAPDH/RPS3/TUBA1B/ACTG1/TUBB/TUBA1C/MYO10/ACTB/CLDN10/TUBB6/CLDN6/NCL/FYN/TUBB4B/MYO1B/CDC42/CLDN7/ACTR3/RAC1/JUN/MYH10/ARPC4/CLDN3/BAIAP2L1/TMED10/GNA12/CLDN19/MYH9/PAK3/ARPC1A/CTTN/ACTR2	2.51272273601699
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/993	89/9376	1.80354617151521	COL1A1/COL6A2/COL1A2/LAMA4/COL4A1/COL4A2/HMMR/COL6A3/COL6A1/LAMB1/LAMA1/ITGA1/COL9A3/SDC4/FRAS1/THBS1/ITGB5	2.62137193920517
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/993	224/9376	1.47532729103726	HLA-G/CCNE1/CALR/PTTG1/RAN/SLC2A1/CCNB2/CDC20/RANBP1/HLA-C/MAD2L1/NFYB/SLC25A6/CCNA2/TBPL1/FDPS/ADCY5/EGR1/VDAC1/VDAC2/ANAPC11/CHEK1/CDK2/JUN/CANX/MAP2K2/AKT1/CCND2/MYC/E2F1/CHEK2/BUB1B/BUB3/CCNE2/E2F3	2.47810259770257
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/993	56/9376	2.02330599913681	OSTC/MAN1A2/DDOST/DAD1/STT3B/TMEM258/B4GALT1/STT3A/TUSC3/ALG9/SRD5A3/MGAT1	2.6433343941167
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/993	37/9376	2.2967257287499	BRAF/PPARG/TCF7L2/CDH1/CTNNB1/MAP2K2/NCOA4/MYC/GADD45A	2.71994004824765
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/993	31/9376	2.43666959035831	RPIA/ALDOA/TKT/PRPS2/GPI/PGLS/ALDOC/PFKP	2.75745619959151
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/993	31/9376	2.43666959035831	ACAT2/GCSH/PCCA/MDH2/GLDC/PGP/ACAT1/SHMT1	2.75745619959151
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/993	63/9376	1.94836873990953	RPA3/POLD2/CDK7/POLR2L/POLR2H/RFC3/LIG1/RFC4/POLE2/PCNA/RFC5/POLR2I/RFC2	2.59934085571106
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/993	78/9376	1.81578743512278	CAV1/ACTG1/ACTB/CDC42/CDH1/CTNNB1/ACTR3/RAC1/CAV2/ARPC4/VCL/PXN/ARPC1A/CTTN/ACTR2	2.4899468209899
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/993	15/9376	3.14736488754616	ALPL/AK2/ACP1/AK5/AK4	2.86451356876347
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/993	93/9376	1.72597429317047	CCNE1/LAMA4/COL4A1/COL4A2/CKS1B/CKS2/SKP2/LAMB1/CDK2/TRAF4/LAMA1/AKT1/MYC/E2F1/GADD45A/CCNE2/E2F3	2.42146987793358
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	22/993	130/9376	1.59789294290805	COL1A1/MMP2/GNAS/COL3A1/COL1A2/COL4A1/COL4A2/RLN2/ACTA2/ADCY5/GNAI1/GRB2/JUN/GNB2/MAP2K2/AKT1/PRKCA/GNAI3/GNG4/GNG7/GNB5/GNB1	2.3625373783416
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/993	27/9376	2.44795046809146	SCD/HSD17B12/ELOVL6/FADS2/ELOVL5/ELOVL1/FADS1	2.59306579946026
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	18/993	103/9376	1.65007479541255	RBM8A/PPP1CB/PAPOLA/MSI2/PABPC1/ALYREF/PPP1CA/PABPC4/PNN/FIP1L1/EIF4A3/PPP1CC/PPP2R1A/MAGOH/UPF3B/PPP2R1B/PPP2R5C/CSTF3	2.28313893263756
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/993	89/9376	1.69745522024961	TUBA1B/TUBB/GNAS/TUBA1C/CDK1/TUBB6/TUBB4B/ADCY5/GNAI1/GRB2/GJA1/MAP2K2/PDGFRB/PRKCA/PDGFRA/GNAI3	2.27527627910536
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	47/993	333/9376	1.33266801544747	HLA-G/CCNE1/COL1A1/GNAS/PKM/COL6A2/COL1A2/HLA-C/LAMA4/COL4A1/COL4A2/COL6A3/COL6A1/CCNA2/TBPL1/LAMB1/TCF7L2/CDC42/CTNNB1/GRB2/PARD3/CDK2/LAMA1/MAP2K2/EIF4EBP1/ITGA1/AKT1/PDGFRB/CCND2/COL9A3/ATP6V1B1/PPP2R1A/HEY1/E2F1/PSMC1/ATP6V0A4/PXN/MAGI1/AXIN1/PPP2R1B/THBS1/PPP2R5C/AXIN2/HDAC2/CCNE2/ITGB5/FOXO1	2.12734255674592
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	25/993	157/9376	1.50351825838192	ACTG1/ACTB/BIRC5/PPP1CB/YWHAQ/ID2/PPP1CA/ID1/TCF7L2/CDH1/YWHAB/BMP4/CTNNB1/TEAD4/PARD3/PPP1CC/CCND2/PPP2R1A/MYC/AXIN1/PPP2R1B/BMP7/SNAI2/CSNK1E/AXIN2	2.18969522579493
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/993	41/9376	2.07265492594503	MMP2/BRAF/CDH1/MAP2K2/MYC/E2F1/FGFR3/THBS1/E2F3	2.3689469108165
NA	NA	hsa03272	Virion - Hepatitis viruses	10/993	48/9376	1.96710305471635	CLDN10/CLDN6/EPCAM/CLDN7/LDLR/CLDN3/DPP4/CHMP4A/CLDN19/CHMP4B	2.31184990484506
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	21/993	128/9376	1.54909365558912	RRM2/IMPDH2/NME1/PAICS/ADCY5/PDE4D/ADA/GMPS/NME2/AK2/PNP/AK5/PRPS2/APRT/NME1-NME2/HDDC2/AK4/ENPP1/ADSL/PDE6H/NT5C	2.15272239776526
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/993	63/9376	1.79849422145495	ACAT2/ALDH7A1/EZH2/DHTKD1/PLOD1/ECHS1/HYKK/AADAT/ACAT1/ALDH1B1/HADH/AASS	2.18855658725639
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	7/993	30/9376	2.20315542128231	IDH2/SDHA/MDH2/FH/SUCLG1/IDH1/PC	2.27159027461683
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/993	37/9376	2.04153398111102	NAGK/UGP2/GNPNAT1/HK1/PGM3/NANS/GPI/PMM1	2.18466397637204
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/993	87/9376	1.62794735562732	TPM1/UQCRH/TPM2/MYL4/TPM4/COX7C/COX6C/COX5A/COX5B/COX8C/UQCRFS1/FXYD2/COX7A1/CYC1/COX7A2L	2.02515799170442
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	15/993	87/9376	1.62794735562732	BIRC5/BRAF/RAC3/TCF7L2/CTNNB1/GRB2/RAC1/JUN/MAP2K2/AKT1/MYC/AXIN1/MSH2/GADD45A/AXIN2	2.02515799170442
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/993	13/9376	2.90525989619645	XRCC5/FEN1/XRCC6/PRKDC	2.36580486167081
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/993	73/9376	1.68146891252466	BRAF/CDH1/IGF1/MAP2K2/FGF7/AKT1/PDGFRB/FGFR1/E2F1/PDGFRA/GADD45A/FGF2/E2F3	2.01166888109863
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	30/993	205/9376	1.38176995063002	HLA-G/CCNE1/CALR/PDIA3/HLA-C/CCNA2/SKP2/PSMD11/PSMD14/PSMC4/RAC1/CDK2/JUN/PSMD3/PSMD6/AKT1/CCND2/MYC/E2F1/PSMC1/ADRM1/PSMD2/PSMC2/GADD45A/PSMD1/PSMD12/HDAC2/PSMD13/CCNE2/E2F3	1.9020890918101
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	21/993	134/9376	1.47973125310006	GNAS/PLA2G2A/CALD1/CALM3/RAMP1/PPP1CB/BRAF/ACTA2/PPP1CA/MYL9/ADCY5/RAMP2/PLA2G10/PPP1CC/MAP2K2/MYH10/MYL6B/PRKCA/GNA12/MYH9/PPP1R14A	1.92498770004371
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/993	59/9376	1.76039053032243	GPX3/RRM2/SRM/MGST1/ODC1/MGST3/GGCT/GSTA4/IDH2/GPX8/IDH1	2.01643945756599
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/993	59/9376	1.76039053032243	BRAF/TCF7L2/CDH1/CTNNB1/GRB2/MAP2K2/AKT1/MYC/AXIN1/GADD45A/AXIN2	2.01643945756599
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	33/993	235/9376	1.32591116539179	RPS6/ACTG1/GNAS/UQCRH/ACTB/NDUFA4/COX20/NDUFB11/COX7C/COX6C/COX5A/COX5B/KDM1A/PPARG/ADCY5/COX8C/UQCRFS1/GRB2/SMARCA2/SDHA/COX7A1/NDUFS2/CYC1/NDUFA4L2/FGFR1/COX7A2L/SMARCC1/COA4/SLC25A29/NDUFS4/NDUFAF2/ACTL6A/NDUFA3	1.74139320403882
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	23/993	154/9376	1.41018296909536	GGH/ALAS2/NME1/DHFR/UMPS/ALPL/UGP2/MTHFD1L/HMBS/NME2/AK2/VKORC1/RDH11/AK5/GCH1/NME1-NME2/MTHFD2/MTHFD1/SHMT1/ALDH1B1/PMM1/AK4/ADSL	1.76638738812773
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/993	41/9376	1.84235993417336	SSBP1/RAD51/RPA3/POLD2/RAD51C/BRCA1/XRCC2/RAD54L	1.86034288902136
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/993	157/9376	1.38323679771137	UQCRH/LEP/NDUFA4/NDUFB11/COX7C/COX6C/COX5A/COX5B/PPARG/CDC42/COX8C/UQCRFS1/RAC1/JUN/SDHA/COX7A1/NDUFS2/AKT1/CYC1/NDUFA4L2/COX7A2L/NDUFS4/NDUFA3	1.66661639836902
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	20/993	133/9376	1.41986385904338	GNAS/CALM3/PPP1CB/PPP1CA/ADCY5/GNAI1/GNB2/PPP1CC/AKT1/COMT/PRKCA/PPP2R1A/TH/PPP2R1B/GNAI3/PPP2R5C/GNG4/GNG7/GNB5/GNB1	1.67837254421154
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/993	28/9376	2.02330599913681	HSD17B12/ELOVL6/ECHS1/ELOVL5/HADH/ELOVL1	1.86631829506889
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/993	28/9376	2.02330599913681	GGH/AKR1B1/DHFR/ALPL/GCH1/TH	1.86631829506889
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/993	42/9376	1.79849422145495	ACAT2/ALDH7A1/DHTKD1/ECHS1/AADAT/ACAT1/ALDH1B1/HADH	1.78493766473777
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/993	35/9376	1.88841893252769	TPI1/AKR1B1/ALDOA/HK1/ALDOC/PFKP/PMM1	1.81223982670595
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/993	110/9376	1.45923281149867	GAPDH/RPS6/LDHA/ENO1/SLC2A1/TIMP1/ALDOA/HK1/IGF1/PGK1/MAP2K2/EIF4EBP1/AKT1/PRKCA/ALDOC/PFKP/ANGPT4	1.6674147317427
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/993	103/9376	1.46673315147782	COL1A1/ARG2/GNAS/COL3A1/COL1A2/LAMA4/SERPINB9/COL4A1/COL4A2/ACTN1/LAMB1/LAMA1/VCL/PRKCA/SERPINB6/ACTN4	1.63922157390424
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/993	43/9376	1.75666877444437	ACAT2/ALDH7A1/ADH5/ECHS1/ACAT1/ALDH1B1/HADH/ACADSB	1.71155136225137
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/993	36/9376	1.83596285106859	PYGL/UGP2/HK1/GYS1/GYG2/GPI/ENPP1	1.72951893110493
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/993	10/9376	2.83262839879154	SELENBP1/MPST/SUOX	1.99552817889194
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/993	227/9376	1.2894490508449	UQCRH/NDUFA4/SLC25A6/MGST1/BRAF/NDUFB11/MGST3/COX7C/COX6C/GSTA4/COX5A/COX5B/COX8C/UQCRFS1/VDAC1/VDAC2/GRB2/ACP1/RAC1/JUN/SDHA/MAP2K2/COX7A1/NDUFS2/AKT1/CYC1/PPIF/NDUFA4L2/COX7A2L/NDUFS4/NDUFA3	1.51935330166492
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/993	82/9376	1.49691744651586	RRM2/TK1/IMPDH2/NME1/MGST1/MGST3/GSTA4/UMPS/DUT/GMPS/NME2/NME1-NME2/NAT1	1.55542962502446
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	20/993	138/9376	1.36841951632442	UQCRH/NDUFA4/PPA1/NDUFB11/COX7C/COX6C/COX5A/COX5B/COX8C/UQCRFS1/SDHA/COX7A1/NDUFS2/CYC1/ATP6V1B1/NDUFA4L2/ATP6V0A4/COX7A2L/NDUFS4/NDUFA3	1.5005612309698
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/993	30/9376	1.88841893252769	SLC19A1/GGH/TYMS/DHFR/SHMT1/ABCG2	1.67735919334884
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/993	122/9376	1.39309593383191	LEP/EEF2/CCNA2/SCD/HMGCR/CAB39L/PPARG/GYS1/IGF1/EIF4EBP1/AKT1/PPP2R1A/PFKP/PPP2R1B/ACACA/PPP2R5C/FASN/FOXO1	1.504091471202
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	28/993	205/9376	1.28965195392135	HLA-G/CCNE1/PKM/CDC20/CDK1/RANBP1/HLA-C/ACTN1/CCNA2/TBPL1/YWHAQ/SKP2/CDC42/REL/YWHAB/HNRNPK/CHEK1/GRB2/RAC1/CDK2/JUN/CCND2/PSMC1/PXN/ACTN4/SND1/HDAC2/CCNE2	1.443130401086
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/993	60/9376	1.57368244377308	GNAS/BRAF/GNAI1/IGF1/MAP2K2/PRKCA/PPP2R1A/GNA12/PPP2R1B/GNAI3	1.53423884427428
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	21/993	148/9376	1.33975667510411	BRAF/TCF7L2/CTNNB1/GRB2/IGF1/JUN/MAP2K2/FGF7/AKT1/BRCA1/FGFR1/MYC/HEY1/E2F1/FLT4/AXIN1/GADD45A/FGF2/AXIN2/E2F3/LRP6	1.43385617865092
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/993	38/9376	1.73933322732814	NAGK/UGP2/GNPNAT1/HK1/PGM3/GPI/PMM1	1.57168539583332
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/993	76/9376	1.49085705199555	CALM3/BRAF/GRB2/IGF1/MAP2K2/AKT1/PDGFRB/PRKCA/E2F1/PDGFRA/GADD45A/E2F3	1.47870276850873
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/993	24/9376	1.96710305471635	EXT1/HS6ST1/HS6ST2/XYLT1/EXTL2	1.63262580354015
NA	NA	hsa04981	Folate transport and metabolism	6/993	31/9376	1.82750219276874	SLC19A1/TYMS/DHFR/MTHFD1/SHMT1/ABCG2	1.5882573605923
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	16/993	108/9376	1.3988288389094	RAN/RBM8A/KPNA2/ALYREF/KPNB1/PNN/EIF4A3/NUP37/THOC3/IPO5/MAGOH/TMEM33/UPF3B/SEC13/TNPO1/CSE1L	1.43471602352766
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/993	54/9376	1.57368244377308	LDHA/SRM/CBS/PHGDH/MDH2/MPST/CISD1/AHCY/CTH	1.4550382811427
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/993	142/9376	1.32987248769556	CAV1/MMP2/ACTG1/ACTB/CALM3/HSP90B1/HSP90AB1/MGST1/MGST3/TXN2/GSTA4/RAC3/BMP4/CTNNB1/GPC1/RAC1/JUN/CAV2/AKT1/SDC4	1.3631883381206
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/993	70/9376	1.48375773270033	SLC2A1/BRAF/CDC42/GRB2/RAC1/JUN/MAP2K2/AKT1/FH/PAK3/RAP1B	1.39815701299335
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/993	70/9376	1.48375773270033	HLA-G/CAV1/ACTG1/ACTB/HLA-C/FYN/RAC3/SSPN/RAC1/LAMA1/SGCB	1.39815701299335
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/993	110/9376	1.37339558729287	GREM2/DCN/ID2/ID1/BMP4/LRRC32/TFDP1/E2F5/PPP2R1A/MYC/ID4/PPP2R1B/BMP7/ZFYVE16/THBS1/HDAC2	1.35575091202221
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	30/993	227/9376	1.24785392017248	HLA-G/CALR/GNAS/PDIA3/HLA-C/CALM3/RAC3/ADCY5/CTNNB1/GNAI1/GRB2/RAC1/CXCL12/GNB2/MAP2K2/EIF4EBP1/AKT1/PRKCA/GNA12/MYC/E2F1/PDGFRA/PXN/IL10RB/GNAI3/GNG4/GNG7/GNB5/E2F3/GNB1	1.30101539751272
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	31/993	238/9376	1.22985266614199	PLA2G2A/CALM3/RALBP1/RAC3/CDC42/REL/GRB2/IGF1/RAC1/PLA2G10/EFNA1/GNB2/MAP2K2/FGF7/AKT1/PDGFRB/PRKCA/FGFR1/FGFR3/FLT4/PAK3/PDGFRA/ANGPT4/RAP1B/EFNA3/FGF2/GNG4/GNG7/GNB5/GNB1/RASGRP2	1.23615513335978
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/993	80/9376	1.41631419939577	RPS6/BRAF/GRB2/IGF1/MAP2K2/EIF4EBP1/AKT1/PDGFRB/PRKCA/FGFR3/PDGFRA/FGF2	1.28700042149587
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/993	155/9376	1.27925153493812	HLA-G/CALR/TUBA1B/ACTG1/TUBB/TUBA1C/ACTB/HLA-C/C1R/TUBB6/SEC61B/SEC61G/TUBB4B/RAC1/CANX/ATP6V1B1/EEA1/ATP6V0A4/SEC61A1/THBS1/ITGB5	1.2065155854591
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/993	34/9376	1.66625199928914	POLR1D/POLR2L/POLR2H/POLR1E/POLR2I/POLR3G	1.33942555828466
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	17/993	122/9376	1.31570171528569	DIO3/ACTG1/ACTB/SLC2A1/DIO2/MED30/BMP4/CTNNB1/FXYD2/MAP2K2/AKT1/PRKCA/PLCD4/MYC/PFKP/HDAC2/FOXO1	1.20796023702473
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/993	115/9376	1.31368273567144	NACA/GNAS/BRAF/GCM1/ADCY5/PDE4D/EGR1/GNAI1/MMP14/PTH1R/MMP15/PRKCA/FGFR1/GNA12/GNAI3/LRP6	1.16485300477811
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	18/993	133/9376	1.27787747313904	CCNB1/BNIP3/CCNB2/BRAF/SKP2/GRB2/IGF1/PRMT1/PLK1/CDK2/MAP2K2/HOMER1/AKT1/CCND2/SGK2/CSNK1E/GADD45A/FOXO1	1.1107932048118
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/993	75/9376	1.38484055052031	GPX3/HSPA5/GNAS/HSP90B1/PDIA4/GPX8/ADCY5/FXYD2/CANX/LRP2/PRKCA	1.15161461048943
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/993	76/9376	1.36661896432925	SCD/PPARG/HMGCS1/PLTP/APOA2/SLC27A2/HMGCS2/FADS2/PLIN2/SLC27A5/SLC27A6	1.10443656730104
Organismal Systems	Immune system	hsa04611	Platelet activation	17/993	126/9376	1.27393340686392	COL1A1/ACTG1/GNAS/COL3A1/ACTB/COL1A2/PPP1CB/FYN/PPP1CA/ADCY5/GNAI1/VASP/PPP1CC/AKT1/RAP1B/GNAI3/RASGRP2	1.06541776576647
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/993	101/9376	1.30880520076177	COL1A1/MMP2/COL3A1/COL1A2/COL4A1/COL4A2/CDC42/EGR1/RAC1/JUN/AKT1/PRKCA/PLCD4/FOXO1	1.07386296053427
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/993	14/9376	2.02330599913681	B4GALT1/B3GNT7/B4GALT4	1.31869921906886
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/993	248/9376	1.18026183282981	GAPDH/RPS3/TUBA1B/ACTG1/TUBB/TUBA1C/ACTB/HSP90B1/HSP90AB1/TUBB6/PFN1/TXN2/DYNLL1/TUBB4B/MYL9/TCF7L2/CDC42/CTNNB1/PIK3C2A/ACTR3/RAC1/JUN/MAP2K2/ARPC4/AKT1/MYC/PAK3/DCTN2/ARPC1A/CSE1L/ACTR2	0.990153065914443
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	22/993	170/9376	1.22191813281204	ACTG1/ACTB/MGST1/BRAF/MGST3/GSTA4/TCF7L2/CTNNB1/GRB2/SMARCA2/MAP2K2/AKT1/PRKCA/MYC/E2F1/AXIN1/SMARCC1/GADD45A/AXIN2/E2F3/LRP6/ACTL6A	1.00494500158235
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/993	69/9376	1.36841951632442	GNAS/CALM3/PPP1CB/PPP1CA/ADCY5/JUN/PPP1CC/PRKCA/TH/HDAC2	1.05711648606802
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	27/993	214/9376	1.19129231724878	HLA-G/CCNB1/CALR/PDIA3/CCNB2/CDK1/HLA-C/CALM3/RAC3/GNAI1/CHEK1/RAC1/JUN/GNB2/WEE1/MAP2K2/AKT1/PRKCA/CDC25C/PAK3/PXN/GNAI3/GNG4/GNG7/GNB5/TNFRSF1B/GNB1	0.974248622492139
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/993	53/9376	1.42522183586996	GNAS/FXYD2/RAB11A/ATP2B4/PTH1R/PRKCA/AP2A1/ATP2B3	1.06840566041408
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/993	86/9376	1.31750158083327	ACTG1/ACTB/DSC2/DSP/TCF7L2/SSPN/CTNNB1/GJA1/LAMA1/ITGA1/ITGB5/SGCB	1.01800002805414
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/993	154/9376	1.22624606008292	TPM1/GNAS/TPM2/CALM3/PPP1CB/MYL4/TPM4/PPP1CA/ADCY5/GNAI1/FXYD2/ATP2B4/PPP1CC/AKT1/PRKCA/PPP2R1A/PPP2R1B/GNAI3/ATP2B3/PPP2R5C	0.974292492019946
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/993	155/9376	1.21833479517916	CCNE1/GNAS/BRAF/PBX1/TCF7L2/ADCY5/CTNNB1/GNAI1/CDK2/LDLR/MAP2K2/FH/WDR5/E2F1/AXIN1/RAP1B/GNAI3/AXIN2/CCNE2/E2F3	0.943322776327981
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/993	138/9376	1.23157756469197	RPS6/PYGL/CALM3/PPP1CB/CBLB/BRAF/PPP1CA/HK1/GRB2/GYS1/PPP1CC/MAP2K2/EIF4EBP1/AKT1/SH2B2/ACACA/FASN/FOXO1	0.943208218191093
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/993	156/9376	1.21052495674852	CLDN10/EIF3E/BRAF/CLDN6/YWHAQ/YWHAB/CTNNB1/CLDN7/GRB2/CDK2/LDLR/MAP2K2/AKT1/CLDN3/PPP2R1A/MYC/E2F1/CLDN19/PPP2R1B/E2F3	0.912559004601083
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/993	140/9376	1.21398359948209	RPS6/CALM3/MYL4/ACTA2/ADCY5/CDH1/MAP1LC3A/EGR1/GNAI1/TFAM/GNB2/MAP2K2/AKT1/GNAI3/GNG4/GNG7/GNB5/GNB1	0.877936436598975
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/993	150/9376	1.19599865726754	CCNE1/BRAF/TCF7L2/CDH1/CTNNB1/GRB2/CDK2/MAP2K2/FGF7/AKT1/MYC/E2F1/AXIN1/GADD45A/FGF2/AXIN2/CCNE2/E2F3/LRP6	0.832822653586288
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/993	32/9376	1.47532729103726	AKR1B1/UGP2/HK1/B4GALT1/PFKP	0.926961835218114
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/993	32/9376	1.47532729103726	LDHA/PCCA/ECHS1/SUCLG1/ACACA	0.926961835218114
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	22/993	178/9376	1.16700046392161	SERPINF1/DKK1/APCDD1/NOTUM/RAC3/TCF7L2/CTNNB1/RAC1/JUN/RUVBL1/CCND2/PRKCA/MYC/AXIN1/CACYBP/CSNK1E/LGR4/AXIN2/CSNK2A1/LRP6/RNF43/RSPO3	0.774179211818475
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/993	33/9376	1.43062040343007	IDH2/DHTKD1/GPT2/AADAT/IDH1	0.852842684199721
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/993	93/9376	1.21833479517916	MMP2/GNAS/CALM3/ADCY5/CDC42/EGR1/GRB2/MMP14/JUN/MAP2K2/PRKCA/LHB	0.728250483253654
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	30/993	253/9376	1.11961596790179	RPS27A/ACTG1/ACTB/BNIP3/UBA52/ACTN1/PFN1/U2AF1/MYL9/CDC42/MAP1LC3A/VDAC1/HK1/ACTR3/RAC1/JUN/UBE2N/CBX3/ARPC4/AKT1/VCL/FNBP1/PLCD4/PXN/TIFA/ACTN4/ARPC1A/CTTN/FOXO1/ACTR2	0.663805904870733
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/993	76/9376	1.24238087666296	ACTG1/GNAS/ACTB/CALM3/CA2/GAST/ADCY5/GNAI1/PRKCA/GNAI3	0.730170366093341
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/993	42/9376	1.34887066609121	CP/MAP1LC3A/VDAC2/NCOA4/SAT2/PCBP2	0.779858357514098
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/993	68/9376	1.24968899946686	CCNA2/BRAF/TCF7L2/GRB2/MAP2K2/EIF4EBP1/AKT1/MYC/RUNX1T1	0.711190927007038
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/993	26/9376	1.45262994809823	PLA2G2A/PLA2G10/FADS2/PLB1	0.795398345767466
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/993	77/9376	1.22624606008292	BRAF/RAD51/RALBP1/RAC3/CDC42/RAC1/AKT1/E2F1/GADD45A/E2F3	0.686070574861424
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	22/993	184/9376	1.12894610096764	EPHB4/SEMA6A/FYN/ENAH/MYL9/RAC3/CDC42/GNAI1/PARD3/RAC1/CXCL12/EFNA1/ROBO1/PRKCA/EPHB3/SEMA5A/PAK3/BMP7/SEMA4B/EFNA3/GNAI3/SRGAP1	0.607956698134678
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/993	52/9376	1.27105120458595	GNAS/CYP2J2/ADCY5/IGF1/LDLR/HSD17B7/LHB	0.674547303352904
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/993	52/9376	1.27105120458595	VDAC1/VDAC2/LDLR/PLTP/APOA2/LRP2/LIPG	0.674547303352904
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/993	105/9376	1.16902124394572	RPS27A/BNIP3/UBA52/TOMM20/PHB2/VCP/TOMM7/MAP1LC3A/JUN/E2F1/TOMM40/CSNK2A1/SAMM50	0.599422695127916
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/993	105/9376	1.16902124394572	TPM1/ACTG1/GNAS/TPM2/ACTB/TPM4/ADCY5/SSPN/IGF1/LAMA1/ITGA1/ITGB5/SGCB	0.599422695127916
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/993	19/9376	1.49085705199555	GCSH/DHTKD1/GLDC	0.73709599226093
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/993	107/9376	1.1471703795729	LDHA/GNAS/PKM/SLC2A1/PYGL/CALM3/GYS1/PRMT1/AKT1/PGAM1/PFKP/ACACA/FOXO1	0.526934200354935
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/993	28/9376	1.34887066609121	B3GNT5/ST3GAL4/B4GALT1/B4GALT4	0.636274689377485
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/993	54/9376	1.22397523404573	UBE2T/FANCI/RAD51/RPA3/RAD51C/BRCA1/FANCD2	0.568071313845779
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/993	144/9376	1.11469173100593	ID2/ID1/BMP4/CTNNB1/GRB2/IGF1/MAP2K2/DLX5/AKT1/FGFR1/MYC/FGFR3/ID4/AXIN1/MEIS1/FGF2/AXIN2	0.477337973445341
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	12/993	99/9376	1.14449632274406	RAC3/GRB2/RAC1/JUN/MAP2K2/EIF4EBP1/AKT1/PDGFRB/CHPT1/PRKCA/PDGFRA/LYPLA1	0.497429048553066
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	14/993	117/9376	1.12982329296529	ACTG1/ACTB/MORF4L2/RBBP7/ACTR6/SMARCA2/RUVBL1/RUVBL2/CDK2AP2/SMARCC1/CECR2/HDAC2/MBD3/ACTL6A	0.48632213726672
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/993	91/9376	1.14135210207718	GNAS/ADCY5/PDE4D/GNAI1/GNB2/PRKCA/GNAI3/GNG4/GNG7/GNB5/GNB1	0.466329127470284
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/993	137/9376	1.10272638395778	TUBA1B/ACTG1/TUBA1C/ACTB/BIRC5/LMNB1/CTSV/PARP1/LMNB2/JUN/MAP2K2/AKT1/GZMB/CTSW/CASP6/GADD45A	0.416860101847359
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/993	21/9376	1.34887066609121	DSEL/CHST12/XYLT1	0.550823848520028
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/993	193/9376	1.07630094600024	CCR7/CXCL14/BRAF/RAC3/ADCY5/CDC42/GNAI1/GRB2/PARD3/RAC1/CXCL12/GNB2/CCL21/AKT1/PXN/RAP1B/GNAI3/GNG4/GNG7/GNB5/GNB1/RASGRP2	0.368618234052388
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/993	30/9376	1.25894595501846	PLA2G2A/CYP2J2/PLA2G10/PLB1	0.488897030812852
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/993	102/9376	1.11083466619276	GNAS/PLA2G2A/CA2/ADCY5/FXYD2/RAB11A/ATP2B4/RAC1/PLA2G10/PRKCA/RAP1B/ATP2B3	0.387349221181828
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	19/993	166/9376	1.0807216782538	CALM3/PPP1CB/SLC25A6/PPP1CA/MYL9/ADCY5/VDAC1/VDAC2/GNAI1/FXYD2/ATP2B4/VASP/PPP1CC/MAP2K2/AKT1/PPIF/GNA12/GNAI3/ATP2B3	0.361139457124315
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/993	157/9376	1.08253314603498	ARG2/CALR/SLC2A1/BSG/ODC1/PBX1/PPARG/UQCRFS1/MFGE8/RAC1/MAP2K2/TYRO3/SLC16A1/THBS1/DUSP8/RAB17/ITGB5/ANO7	0.358919329804244
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/993	139/9376	1.08685981728213	MMP2/GNAS/KRT19/CALM3/HSP90B1/HSP90AB1/ADCY5/GNAI1/GRB2/KRT10/JUN/KRT23/MAP2K2/AKT1/GNAI3/KRT24	0.355076041130689
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/993	67/9376	1.12741428807624	CALM3/PPP1CB/BRAF/PPP1CA/PPP1CC/MAP2K2/PRKCA/RAP1B	0.360217284133599
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/993	49/9376	1.15617485664961	GNAS/ADCY5/GNAI1/JUN/TH/GNAI3	0.377223462400556
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/993	86/9376	1.09791798402773	CBLB/BRAF/GRB2/JUN/MAP2K2/EIF4EBP1/AKT1/PRKCA/MYC/PAK3	0.313952800567558
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/993	77/9376	1.10362145407463	BRAF/GRB2/MAP2K2/AKT1/MYC/E2F1/GADD45A/HDAC2/E2F3	0.314222623540497
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/993	50/9376	1.13305135951662	HBA2/HBA1/GYPA/GYPB/GYPC/THBS1	0.324651297192948
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	24/993	217/9376	1.04428696729642	GNAS/BIRC5/KPNA2/HSP90B1/HSP90AB1/MGST1/MGST3/CDC6/GSTA4/KPNB1/ADCY5/GNAI1/GRB2/JUN/MAP2K2/FGF7/EIF4EBP1/AKT1/PRKCA/MYC/E2F1/CDC25A/FGF2/GNAI3	0.227165465080162
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/993	115/9376	1.06736722273304	GNAS/CYP2J2/BRAF/ADCY5/GNAI1/APP/GNB2/PRKCA/GNAI3/GNG4/GNG7/GNB5/GNB1	0.250166499141788
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/993	23/9376	1.23157756469197	ARG2/GPT2/ASL	0.382688545008435
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/993	97/9376	1.07075300297962	GNAS/CALM3/ADCY5/GNAI1/GNB2/PRKCA/GNAI3/GNG4/GNG7/GNB5/GNB1	0.241068622653959
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/993	60/9376	1.10157771064115	RAC3/CDC42/RAC1/MAP2K2/AKT1/PRKCA/PXN	0.271656333690694
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/993	51/9376	1.11083466619276	PLA2G2A/PAFAH1B3/PLA2G10/CHPT1/PLB1/LPCAT1	0.273147238888715
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/993	98/9376	1.05982695192881	MYO10/CDC42/ACTR3/RAC1/VASP/ARPC4/AKT1/PRKCA/MARCKSL1/ARPC1A/ACTR2	0.204900614112757
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	22/993	201/9376	1.03346309740322	CCNA2/ID2/PBX1/PPARG/IGFBP3/REL/IGF1/ETV5/ZEB1/MYCN/DDX5/GZMB/CCND2/MYC/RUNX1T1/MLF1/LMO2/HOXA10/MEIS1/GADD45A/HDAC2/FOXO1	0.165052329861491
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/993	89/9376	1.06090951265601	ADCY5/GNAI1/GNB2/PRKCA/HAP1/GNAI3/GNG4/GNG7/GNB5/GNB1	0.198702318506533
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/993	99/9376	1.04912162918205	MMP2/GNAS/BRAF/ADCY5/GRB2/IGF1/JUN/MAP2K2/AKT1/E2F1/E2F3	0.16910136398893
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/993	99/9376	1.04912162918205	TPM1/ACTG1/TPM2/ACTB/TPM4/SSPN/IGF1/LAMA1/ITGA1/ITGB5/SGCB	0.16910136398893
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/993	82/9376	1.03632746297251	HLA-G/CALR/HSPA5/PDIA3/HLA-C/HSP90AB1/NFYB/HSPA2/CANX	0.113710662617329
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	21/993	196/9376	1.01165299956841	HLA-G/RPS27A/UBA52/HLA-C/CALM3/TCF7L2/MAP1LC3A/CTNNB1/RAC1/JUN/GNB2/MAP2K2/AKT1/MYC/E2F1/FGF2/GNG4/GNG7/GNB5/E2F3/GNB1	0.0567420412073948
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/993	73/9376	1.03475010001517	BRAF/GRB2/MAP2K2/AKT1/PRKCA/E2F1/GADD45A/E2F3	0.10258090065563
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/993	160/9376	1.00322255790534	HLA-G/CLDN10/HLA-C/JAM3/VCAN/CLDN6/CDH1/NRXN3/CLDN7/PTPRS/CNTNAP2/CLDN3/SDC4/CLDN19/SELL/CD276/CD274	0.0141497907502924
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/993	36/9376	1.04912162918205	GCNT1/GALNT2/C1GALT1/GALNT1	0.101627467642225
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/993	75/9376	1.00715676401477	BIRC5/TOP2A/MGST1/MGST3/GSTA4/AKT1/BRCA1/MSH2	0.0214162306755126
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/993	17/9376	1.11083466619276	CTH/SEPHS1	0.157414916756186
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/993	17/9376	1.11083466619276	MYH10/MYH9	0.157414916756186
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/993	191/9376	0.988701011794604	GNAS/CALM3/PPP1CB/BRAF/PPP1CA/ADCY5/SLC29A1/GNAI1/GRB2/PKIA/GNB2/PPP1CC/TH/SLC29A2/GNAI3/HDAC2/GNG4/GNG7/GNB5/GNB1	-0.0542971691837829
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/993	37/9376	1.02076699055551	GPT2/RIMKLB/ASL/ADSL	0.0435596888695708
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/993	37/9376	1.02076699055551	ADH5/GSTZ1/COMT/TH	0.0435596888695708
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/993	37/9376	1.02076699055551	HBA2/HBA1/LAMA4/PRKCA	0.0435596888695708
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	17/993	163/9376	0.984758339048184	CCNE1/BIRC5/CCNA2/BRAF/YWHAQ/YWHAB/GRB2/CDK2/JUN/MAP2K2/AKT1/PRKCA/MYC/E2F1/PCNA/CCNE2/E2F3	-0.067559448016236
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	26/993	250/9376	0.981977844914401	HLA-G/CAV1/HLA-C/CBLB/ARF4/CDC42/EHD3/RAB11A/PARD3/MVB12A/ACTR3/CAV2/LDLR/VPS28/ARPC4/CHMP4A/FGFR3/EEA1/VPS29/AP2A1/PDGFRA/ZFYVE16/ARPC1A/SNF8/CHMP4B/ACTR2	-0.0994024352078335
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/993	125/9376	0.981977844914401	FYN/RAC3/GNAI1/DEGS2/RAC1/MAP2K2/AKT1/PRKCA/PPP2R1A/GNA12/PPP2R1B/GNAI3/PPP2R5C	-0.0698116524593218
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/993	154/9376	0.980996848066334	ACTG1/GNAS/ACTB/EEF2/CALM3/PPP1CB/PPP1CA/MYL9/ADCY5/GNAI1/JUN/PPP1CC/MAP2K2/MYL6B/PRKCA/GNAI3	-0.0818340361237636
NA	NA	hsa04519	Cadherin signaling	42/993	404/9376	0.981603900571326	ACTG1/KRT19/ACTB/PPP1CB/ACTN1/DSC2/YWHAQ/DSP/ENAH/PPP1CA/LIMA1/RAC3/MYO1B/TCF7L2/CDC42/CDH1/YWHAB/CTNNB1/TEAD4/KRT10/GJA1/ACTR3/RAC1/KRT23/VASP/PPP1CC/MAP2K2/DSC3/ARPC4/VCL/PDGFRB/FGFR1/FLT4/PDGFRA/MYO7A/ACTN4/AXIN1/ARPC1A/AXIN2/KRT24/LRP6/ACTR2	-0.13008652953654
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/993	116/9376	0.976768413376393	GNAS/SLC1A2/ADCY5/GNAI1/GNB2/HOMER1/PRKCA/GNAI3/GNG4/GNG7/GNB5/GNB1	-0.0866488697251142
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/993	28/9376	1.01165299956841	CA2/ATP6V1B1/ATP6V0A4	0.0212528865317839
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/993	18/9376	1.04912162918205	ACACA/FASN	0.0717923259220797
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/993	38/9376	0.993904701330365	NNMT/PNP/ENPP1/NT5C	-0.0129574751251581
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/993	59/9376	0.960213016539505	GNAS/ADCY5/GNAI1/ABHD5/AKT1/GNAI3	-0.105508998531647
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/993	69/9376	0.957893661427091	FYN/RAC3/GRB2/RAC1/MAP2K2/AKT1/PRKCA	-0.120816902202838
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/993	109/9376	0.952871938431405	SLC2A1/PYGL/PPP1CB/PPP1CA/GYS1/PPP1CC/AKT1/SLC27A2/SLC27A5/SLC27A6/FOXO1	-0.170327108536946
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/993	149/9376	0.950546442547497	NDUFA4/NDUFB11/ADCY5/GNAI1/GNB2/NDUFS2/PRKCA/NDUFA4L2/GNAI3/NDUFS4/GNG4/GNG7/GNB5/NDUFA3/GNB1	-0.209421343501176
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/993	90/9376	0.944209466263847	GNAS/SLC2A1/CA2/HMGCR/ADCY5/FXYD2/LDLR/SLC27A5/ABCG2	-0.183032394204823
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/993	71/9376	0.930910741386891	ELF5/GRB2/MAP2K2/AKT1/CCND2/TH/LHB	-0.201113881211301
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/993	20/9376	0.944209466263847	UGP2/NANS	-0.0859589173375077
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	12/993	122/9376	0.928730622554604	CBLB/FYN/CDC42/GRB2/JUN/MAP2K2/MAP3K8/AKT1/PPP2R1A/PAK3/PPP2R1B/PPP2R5C	-0.27269593386162
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/993	31/9376	0.913751096384368	ALDH7A1/ECHS1/ALDH1B1	-0.165540897906511
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/993	83/9376	0.910081413266359	AURKB/EZH2/RBBP7/SUZ12/CBX3/TFDP1/WDR5/HDAC2	-0.28318554372116
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/993	21/9376	0.899247110727473	ALDH1B1/ENPP1	-0.159076413160217
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/993	63/9376	0.899247110727473	PTGDS/PLA2G2A/CYP2J2/PLA2G10/PTGR1/PLB1	-0.276149023471604
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/993	63/9376	0.899247110727473	TCF7L2/BMP4/CTNNB1/AXIN1/GADD45A/AXIN2	-0.276149023471604
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/993	43/9376	0.878334387222183	PLA2G2A/ACAT2/PLA2G10/ACAT1	-0.275202244789249
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/993	115/9376	0.903156880774114	FYN/ADCY5/GNAI1/GNB2/AKT1/PRKCA/GNAI3/GNG4/GNG7/GNB5/GNB1	-0.359624504615759
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/993	22/9376	0.858372242058043	ALDH7A1/ALDH1B1	-0.2288872319507
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/993	44/9376	0.858372242058043	HLA-G/HSPD1/HLA-C/GZMB	-0.32407675575787
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/993	44/9376	0.858372242058043	GNAS/DYNLL1/RAB11A/DCTN2	-0.32407675575787
NA	NA	hsa04382	Cornified envelope formation	21/993	217/9376	0.913751096384368	KRT19/CLDN10/COL4A1/COL4A2/CLDN6/DSP/CLDN7/S100A13/PADI1/KRT10/KRT23/ABHD5/CLDN3/CASP14/S100A1/PPP2R1A/CLDN19/PPP2R1B/ELOVL1/PPP2R5C/KRT24	-0.442404921776675
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	15/993	158/9376	0.89640139202264	RPS6/BRAF/SKP2/CAB39L/EIF4B/GRB2/IGF1/MAP2K2/EIF4EBP1/AKT1/SLC38A9/PRKCA/ATP6V1B1/SEC13/LRP6	-0.451985643978972
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/993	138/9376	0.88947268561087	ACTG1/ACTB/RAC3/CDC42/ACTR3/RAC1/JUN/MAP2K2/ARPC4/AKT1/PXN/ARPC1A/ACTR2	-0.450174313755666
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/993	23/9376	0.821051709794649	B4GALT1/B3GALNT2	-0.295717164577325
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/993	23/9376	0.821051709794649	ENPEP/REN	-0.295717164577325
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/993	23/9376	0.821051709794649	CA2/FXYD2	-0.295717164577325
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	29/993	300/9376	0.912735817388385	STMN1/BRAF/RAC3/CDC42/GRB2/IGF1/RAC1/JUN/EFNA1/MAP2K2/MAP3K8/FGF7/AKT1/PDGFRB/PRKCA/FGFR1/GNA12/MYC/FGFR3/FLT4/PDGFRA/ECSIT/ANGPT4/DUSP8/RAP1B/EFNA3/GADD45A/FGF2/RASGRP2	-0.528700764265373
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/993	78/9376	0.847367469723965	TPI1/PIK3C2A/PPIP5K2/PLCD4/INPP4B/SYNJ1/IP6K2	-0.465865085901031
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/993	99/9376	0.858372242058043	GNAS/CYP2J2/CALM3/PPP1CB/PPP1CA/ADCY5/IGF1/PPP1CC/PRKCA	-0.487554005139341
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	11/993	120/9376	0.865525344075193	CALM3/BRAF/CDC42/GRB2/RAC1/JUN/MAGED1/MAP2K2/AKT1/SH2B2/RAP1B	-0.510246366975709
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/993	12/9376	0.786841221886539	VKORC1	-0.254286715319582
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/993	36/9376	0.786841221886539	AKR1B1/UGP2/DCXR	-0.441003020178677
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/993	69/9376	0.821051709794649	GNAS/CALM3/ADCY5/GNAI1/REN/GNAI3	-0.51346136495979
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/993	101/9376	0.841374771918279	GNAS/CALM3/TCF7L2/ADCY5/CTNNB1/GNAI1/MAP2K2/PRKCA/GNAI3	-0.551615570667387
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/993	122/9376	0.851336404008387	GNAS/ADCY5/IGFBP3/GNAI1/GRB2/IGF1/MAP2K2/GHR/AKT1/PRKCA/GNAI3	-0.568827168038889
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/993	226/9376	0.87736277838676	GNAS/CALM3/PPP1CB/BRAF/PPP1CA/MYL9/RAC3/ADCY5/PDE4D/GNAI1/FXYD2/ATP2B4/RAC1/JUN/PPP1CC/MAP2K2/AKT1/LHB/RAP1B/GNAI3/ATP2B3	-0.642283114701215
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/993	71/9376	0.797923492617335	JAM3/CDC42/RAC1/JUN/ATP6V1B1/ATP6V0A4	-0.588230233138454
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/993	49/9376	0.770783237766406	GALNT2/C1GALT1/B4GALT1/GALNT1	-0.553648279530649
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/993	26/9376	0.726314974049113	SLC19A1/PLB1	-0.480941700427257
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/993	38/9376	0.745428525997774	FXYD2/IGF1/PRKCA	-0.541171765444652
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/993	61/9376	0.77394218546217	FXYD2/SLC39A4/ATP2B4/SLC6A19/ATP2B3	-0.609612048506587
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/993	39/9376	0.726314974049113	HLA-G/HLA-C/GZMB	-0.589440795245581
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/993	73/9376	0.776062575011381	PPIA/RAN/MAP1B/CHMP4A/CHMP4B/PSIP1	-0.661054291521571
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/993	62/9376	0.761459246986973	ADCY5/IGF1/AKT1/HDAC2/FOXO1	-0.648561020249452
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	30/993	323/9376	0.876974736467969	CCNE1/TPM1/STMN1/EZH2/IGF2BP1/HNRNPK/CDCA5/GRB2/ZEB1/KIF23/EFNA1/MAP2K2/BRCA1/PDGFRB/CCND2/PRKCA/CDC25C/SOX4/MYC/E2F1/FGFR3/FSCN1/PDGFRA/THBS1/CDC25A/EFNA3/CCNG1/HDAC2/CCNE2/E2F3	-0.774390175160778
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	16/993	180/9376	0.839297303345642	HLA-G/CALR/PDIA3/HLA-C/PPP1CB/SRSF9/SRSF3/ALYREF/PPP1CA/SRSF2/SRSF7/SRSF6/PPP1CC/EIF4EBP1/AKT1/EIF2B2	-0.749239154465008
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/993	15/9376	0.629472977509231	SLC33A1	-0.494270763983292
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/993	29/9376	0.651178942250929	TEAD4/CSNK1E	-0.647479617765911
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/993	29/9376	0.651178942250929	CALM3/GNB1	-0.647479617765911
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/993	98/9376	0.770783237766406	CALM3/PIK3C2A/PPIP5K2/PRKCA/PLCD4/INPP4B/SYNJ1/IP6K2	-0.785041755135549
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/993	65/9376	0.726314974049113	MAP2K2/AKT1/KISS1R/PRKCA/LHB	-0.762026511412306
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/993	142/9376	0.797923492617335	RPS27A/UBE2C/UBE2S/CDC20/UBA52/CBLB/SKP2/SAE1/ANAPC11/UBE2N/FBXW7/BRCA1	-0.83507521405186
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/993	66/9376	0.715310201715036	DHRS9/HSD17B12/HSD17B7/COMT/SRD5A3	-0.798784375537264
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/993	78/9376	0.726314974049113	CALM3/C1R/C1S/GNAI1/JUN/GNAI3	-0.835341574262398
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/993	17/9376	0.555417333096381	SLC27A5	-0.631426483300468
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/993	17/9376	0.555417333096381	CA2	-0.631426483300468
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/993	112/9376	0.758739749676306	LAMA4/LAMB1/GNAI1/LAMA1/LDLR/AKT1/PPIF/IL10RB/GNAI3	-0.884007687236728
NA	NA	hsa04081	Hormone signaling	19/993	219/9376	0.819177162512013	GNAS/LEP/RAMP1/DIO2/GAST/ADCY5/RAMP2/GNAI1/IGF1/PTH1R/GNB2/GHR/GNA12/LHB/GNAI3/GNG4/GNG7/GNB5/GNB1	-0.931878430684826
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/993	31/9376	0.609167397589579	ALDH7A1/ALDH1B1	-0.750140317406115
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/993	56/9376	0.674435333045605	LRP2/CCND2/GAS1/CSNK1E	-0.84097648444905
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/993	56/9376	0.674435333045605	HSPD1/BNIP3/SAR1A/VCP	-0.84097648444905
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/993	91/9376	0.726314974049113	RAC3/GRB2/RAC1/JUN/MAP2K2/AKT1/IFITM1	-0.902903440966696
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/993	103/9376	0.73336657573891	CALR/GNAS/GNAI1/JUN/AKT1/PPP2R1A/PPP2R1B/GNAI3	-0.936447861029024
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/993	18/9376	0.524560814591026	MMADHC	-0.694864676179764
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/993	45/9376	0.629472977509231	HLA-G/HLA-C/GZMB	-0.857477193911952
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/993	104/9376	0.726314974049113	PLA2G2A/PHOSPHO1/PLA2G10/CHPT1/SAMD8/LYPLA1/PLB1/LPCAT1	-0.965920813276307
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/993	93/9376	0.710695297187842	GNAS/CALM3/ADCY5/FXYD2/ATP2B4/PRKCA/ATP2B3	-0.964968911426269
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/993	46/9376	0.615788782345987	ALAS2/CP/HMBS	-0.899018572917904
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/993	83/9376	0.682561059949769	FAR2/IDH2/DAO/SLC27A2/PHYH/IDH1	-0.999727888325017
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/993	34/9376	0.555417333096381	RORB/CSNK1E	-0.89378401484186
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/993	48/9376	0.590130916414904	HK1/FXYD2/AKT1	-0.979787828467829
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/993	98/9376	0.674435333045605	GNAS/CALM3/ADCY5/ATP2B4/LDLR/PRKCA/ATP2B3	-1.11502254488498
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/993	144/9376	0.721271120062661	ALDH7A1/ADH5/SCD/TCF7L2/CTNNB1/TRA2A/AKT1/ALDH1B1/ACACA/FASN/FOXO1	-1.16004769936814
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/993	133/9376	0.709931929521689	HLA-G/HLA-C/BRAF/FYN/RAC3/GRB2/RAC1/MAP2K2/GZMB/PRKCA	-1.15952415278714
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/993	99/9376	0.667622854934033	KRT19/CFD/C1R/C1S/KRT10/KRT23/KRT24	-1.14420937426761
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/993	38/9376	0.496952350665183	ADA/UNG	-1.06938605576415
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/993	65/9376	0.58105197923929	ALDH7A1/AKR1B1/LIPG/ALDH1B1	-1.16648507756016
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/993	65/9376	0.58105197923929	GNAS/PBX1/ADCY5/LDLR	-1.16648507756016
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/993	90/9376	0.629472977509231	PPARG/ADCY5/IGF1/EIF4EBP1/AKT1/FOXO1	-1.21559059400291
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/993	79/9376	0.597600928015093	MGST1/ADH5/MGST3/GSTA4/AKR7A2	-1.23611714459982
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/993	79/9376	0.597600928015093	SLC1A2/ATP6V1B1/AP2A1/ATP6V0A4/CPLX1	-1.23611714459982
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/993	54/9376	0.524560814591026	HLA-G/HLA-C/GZMB	-1.20586262074807
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/993	70/9376	0.539548266436484	LEP/SLC2A1/AKT1/TNFRSF1B	-1.3307979943456
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/993	70/9376	0.539548266436484	MGST1/MGST3/GSTA4/NAT1	-1.3307979943456
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/993	83/9376	0.568800883291474	POLR1D/POLR2L/POLR2H/G3BP1/POLR3G	-1.35799906062695
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/993	44/9376	0.429186121029021	TBPL1/CDK7	-1.30615292317409
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/993	216/9376	0.699414419454701	HSPA5/HSPD1/CYP2J2/CALM3/HSP90B1/HSP90AB1/HSPA2/PPARG/CDC42/RAC1/JUN/LDLR/AKT1/PRKCA/CASP6/RAP1B	-1.53818230582593
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/993	86/9376	0.548958992013864	GNAS/SLC2A1/ADCY5/FXYD2/PRKCA	-1.44616526814891
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/993	73/9376	0.517375050007587	MGST1/ADH5/MGST3/GSTA4	-1.42468948369877
Human Diseases	Infectious disease: viral	hsa05162	Measles	9/993	136/9376	0.624844499733428	CCNE1/CBLB/EIF3H/CDK2/JUN/AKT1/CCND2/CSNK2A1/CCNE2	-1.51671965961246
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/993	45/9376	0.419648651672821	ABCA7/ABCG2	-1.34305466387139
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/993	100/9376	0.566525679758308	CCR7/CXCL14/CXCL12/CCL21/IL10RB/TNFRSF1B	-1.49983517121907
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/993	149/9376	0.633697628364998	GNAS/FYN/ADCY5/GRB2/MAP2K2/AKT1/PDGFRB/PRKCA/GNA12/PDGFRA	-1.55118334751035
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/993	47/9376	0.401791262239935	PKM/HK1	-1.41496163316737
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/993	90/9376	0.524560814591026	JUN/MAP2K2/AKT1/CSNK2A1/CD274	-1.55977666060227
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/993	32/9376	0.295065458207452	IGBP1	-1.3747315352811
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/993	32/9376	0.295065458207452	BIRC5	-1.3747315352811
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/993	105/9376	0.539548266436484	PARP1/CXCL12/CCL21/ERC1/GADD45A/CSNK2A1	-1.63296170745027
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/993	169/9376	0.614574208810788	HMGB1/RPS27A/BNIP3/UBA52/MAP1LC3A/IGBP1/MAP2K2/AKT1/NRBF2/RAB33B/GORASP2	-1.74014557979181
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/993	183/9376	0.619153748369736	RAN/FBL/DKC1/GAR1/GNL3/NOP56/POP7/NOP58/EIF6/POP1/CSNK2A1/NOB1	-1.79063525021761
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/993	68/9376	0.416562999822285	DHRS9/ADH5/RDH11	-1.66180769634456
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/993	173/9376	0.600364400514585	ACTG1/ACTB/KPNA2/SLC25A6/FDPS/VDAC1/RAB11A/DNAJC3/MAP2K2/AKT1/PRKCA	-1.82592543390036
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/993	55/9376	0.343348896823217	DEGS2/SAMD8	-1.68091324135252
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/993	88/9376	0.429186121029021	CFD/C1R/C1S/SERPINB2	-1.85154932567658
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/993	168/9376	0.562029444204671	HMGB1/PPIA/PYGL/HSP90AB1/SLC25A6/PARP1/VDAC1/VDAC2/CHMP4A/CHMP4B	-1.97141215233377
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/993	143/9376	0.528229072035719	C1R/SNRPD1/ACTN1/SNRPB/C1S/SNRPD3/SSB/ACTN4	-1.95653808048378
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/993	254/9376	0.631951217578165	GNAS/CALM3/SLC25A6/VDAC1/VDAC2/ATP2B4/FGF7/PPIF/PDGFRB/PRKCA/FGFR1/PLCD4/FGFR3/FLT4/PDGFRA/FGF2/ATP2B3	-2.0466224751809
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/993	195/9376	0.58105197923929	HMGB1/ACTG1/ACTB/SLC25A6/VDAC1/VDAC2/RAC1/MAP2K2/AKT1/PPIF/PRKCA/HDAC2	-2.03466532744895
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/993	62/9376	0.304583698794789	HEY1/HDAC2	-1.8907457116274
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/993	94/9376	0.401791262239935	HSP90B1/HSP90AB1/JUN/TRAF4	-2.00611777707822
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/993	109/9376	0.433123608377911	RAC1/JUN/MAP2K2/MAP3K8/AKT1	-2.04876698657153
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/993	95/9376	0.397561880532146	JUN/CXCL12/ATP6V1B1/ATP6V0A4	-2.03112845233724
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/993	168/9376	0.505826499784204	LEP/GRB2/GHR/AKT1/PDGFRB/CCND2/MYC/PDGFRA/IL10RB	-2.22439529506181
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/993	142/9376	0.465455370693446	FYN/PPARG/GRB2/RAC1/JUN/AKT1/FHL2	-2.20898993415965
NA	NA	hsa04082	Neuroactive ligand signaling	11/993	199/9376	0.521924830598106	GNAS/SLC1A2/ADCY5/GNAI1/GNB2/PRKCA/GNAI3/GNG4/GNG7/GNB5/GNB1	-2.34602636954697
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/993	50/9376	0.188841893252769	CXCL12	-1.97926223783663
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/993	119/9376	0.396726666497415	MMP14/JUN/MAP3K8/AKT1/TNFRSF1B	-2.279360441668
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/993	105/9376	0.359698844290989	CALM3/CBLB/JUN/AKT1	-2.27078582247261
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/993	78/9376	0.242104991349704	JUN/MARCKSL1	-2.31324752770786
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/993	100/9376	0.283262839879154	GYPA/ITGA1/CD7	-2.47993376094237
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/993	66/9376	0.143062040343007	JUN	-2.404401763261
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/993	187/9376	0.403939878615549	HSP90AB1/TRIP6/TXN2/MAP1LC3A/VDAC1/VDAC2/JUN/SUGT1	-2.83359171330533
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/993	181/9376	0.365163881980493	HSPD1/CALM3/NFYB/AKT1/EEA1/ATP6V0A4/IL10RB	-2.96814817122744
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	11/993	250/9376	0.415452165156093	CTSV/LAPTM4B/SLC29A1/CTSE/SLC38A9/ATP6V1B1/VPS29/AP2A1/ATP6V0A4/SLC29A2/CTSW	-3.22411376458417
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/993	109/9376	0.173249443351165	HSP90AB1/JUN	-2.98798692558883
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/993	93/9376	0.101527899598263	JUN	-2.99683218504218
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/993	298/9376	0.411903458437249	CCR7/LEP/CXCL14/BMP4/TNFRSF21/CXCL12/CCL21/GHR/GDF11/IL10RB/BMP7/ACVRL1/TNFRSF1B	-3.55076718517078
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/993	370/9376	0.306230097166653	LEP/TMEM97/RLN2/GZMA/GAL/NPW/PTH1R/PAQR9/GHR/KISS1R/LHB/CHRNA5	-4.68609269871994
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/993	449/9376	0.0630874921779853	CALM3/GNG7/GNB1	-7.00212677220905