category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	93/1368	222/9376	2.87118697645013	RPS9/RPL29/RPL7A/RPL18A/RPL28/RPL19/RPSA/RPL5/RPL36/RPS3A/RPS5/RPS15/RPL15/RPL8/RPS13/RPS6/RPLP0/RPS18/MRPS15/MRPL23/MRPL41/RPL6/RPS4X/RPS27A/RPL14/MRPL4/RPL3/RPL13A/RPL35A/RPS7/MRPS16/MRPL12/RPL22L1/RPL22/MRPS7/RPL4/MRPS5/MRPL3/RPL10/MRPS9/MRPS35/RPL11/MRPL20/MRPS2/MRPS12/MRPL51/MRPL11/RPS26/MRPL32/MRPL35/RPL37A/MRPS22/MRPL36/MRPL9/MRPL15/MRPL54/MRPS27/MRPL52/MRPL14/RSL24D1/MRPL47/MRPL18/MRPS14/MRPL19/MRPS31/MRPL40/MRPL22/MRPL24/MRPS30/MRPL21/MRPL45/MRPL37/MRPL55/MRPS18C/MRPL42/MRPS6/MRPS25/MRPL44/MRPS26/MRPL50/MRPL43/MRPS34/MRPL13/MRPS18B/MRPS28/MRPS23/RPL26L1/DAP3/MRPS18A/MRPL28/MRPL39/MRPL10/MRPL49	11.6615122797859
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	51/1368	108/9376	3.23651721897336	RAN/KPNA2/RBM8A/IPO5/ALYREF/KPNB1/XPO1/NUP37/THOC7/PNN/NCBP2/CSE1L/SEH1L/POM121/UPF3B/EIF4A3/THOC1/TMEM33/SEC13/NUP205/IPO7/TNPO3/NMD3/NUP50/RAE1/NUP54/POM121C/ACIN1/NUP88/NUP98/THOC2/MAGOHB/NDC1/IPO4/KPNA4/TNPO1/NUP62/PHAX/AHCTF1/UPF1/NCBP1/DDX39B/NUP210/NUP107/XPO4/XPOT/THOC3/NUP160/NUP153/IPO9/XPO5	9.661793830573
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	47/1368	116/9376	2.77697116354104	GAPDH/PHGDH/ENO1/PKM/ACAT2/TPI1/RPIA/MDH2/TKT/ACAT1/PGAM1/PGLS/IDH1/GPI/PGK1/PDHB/PCCA/IDH3G/PCCB/SUCLG2/GCSH/SDHA/HK1/DLD/SHMT2/GPT2/CS/ADH5/PDHA1/SDHC/SDHB/PRPS2/IDH3A/SHMT1/FH/GOT1/SDHD/IDH3B/GLDC/ACO2/SUCLA2/ACSS2/PGD/G6PD/GLUD1/DLAT/ACO1	7.95922049406049
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	60/1368	174/9376	2.36337971365195	HSP90AB1/HSPA5/SSR4/OSTC/PDIA6/LMAN1/HSPA8/SSR3/HSP90B1/HSP90AA1/CALR/MAN1A2/SAR1A/CANX/STT3B/ERP29/UBXN4/PDIA4/LMAN2/HSPBP1/EIF2S1/SAR1B/UBE2D3/CAPN1/GANAB/SEC61B/DNAJB11/DERL2/BAG1/CRYAB/RRBP1/UBE2D2/DNAJC10/PDIA3/DNAJC3/SEC61A1/SEC61G/UBXN1/STT3A/DERL1/UBE2G1/SEC13/XBP1/PRKCSH/SEC63/SSR1/PLAA/DNAJA2/CKAP4/UBE2J2/MAGT1/CUL1/ERN1/NGLY1/MBTPS2/UBE2G2/BAK1/MOGS/HYOU1/UGGT1	7.50268981964065
Genetic Information Processing	Transcription	hsa03040	Spliceosome	72/1368	243/9376	2.03075590210093	RBM8A/TXNL4A/HNRNPA3/HNRNPC/SRSF3/HNRNPA1/HSPA8/PRPF40A/SRSF2/SRSF9/ALYREF/LSM7/SNRPA/SRSF7/LSM4/U2AF1/HNRNPM/SNRPD1/HNRNPU/SRSF1/RBMX/SNRPE/PUF60/SRSF4/THOC7/SRSF5/PRPF38B/NCBP2/SF3B1/RBM25/SNRNP70/SNRPD2/SNRPF/FUS/TRA2A/TRA2B/HNRNPK/PRPF4/LSM5/DDX5/RBM17/EIF4A3/THOC1/SNRNP40/U2SURP/TCERG1/SRSF10/SRSF6/PPIL1/PPIH/SF1/BCAS2/RBM22/PQBP1/PLRG1/PRPF38A/ACIN1/THOC2/MAGOHB/RP9/PRPF19/U2AF2/PRPF31/HNRNPA1L2/DHX16/RBMX2/NCBP1/DDX39B/WBP11/DDX23/THOC3/PRPF8	6.72850985559187
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	19/1368	30/9376	4.34074074074074	MDH2/IDH1/PDHB/IDH3G/SUCLG2/SDHA/DLD/CS/PDHA1/SDHC/SDHB/IDH3A/FH/SDHD/IDH3B/ACO2/SUCLA2/DLAT/ACO1	7.5745557611135
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	97/1368	368/9376	1.80657259089753	NDUFA4/GPX3/CHCHD10/ACTG1/UQCRH/HSPA5/NDUFV3/TUBA1C/HNRNPA3/TOMM40/COX5A/CYC1/SRSF3/HNRNPA1/UQCRFS1/CYCS/NDUFS7/NDUFA3/NDUFC1/VDAC1/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/NDUFA9/ALYREF/NDUFS2/SRSF7/PSMA7/NDUFB9/KIF5B/COX8C/NDUFC2/EIF2S1/NDUFA8/NUP37/COX6A1/UQCRC1/MAPK13/NDUFA12/SDHA/PSMC4/NDUFS3/FUS/SEH1L/SIGMAR1/PSMD8/TARDBP/POM121/NDUFS4/NDUFB7/HNRNPA2B1/PSMC5/PSMD3/TUBB4B/PSMD12/SDHC/DERL1/SDHB/SEC13/PSMD11/NUP205/XBP1/NDUFS8/PSMD6/NUP50/RAE1/MAPK14/NUP54/MATR3/SDHD/POM121C/CASP3/NUP88/NUP98/ERN1/NDC1/CCS/HNRNPA1L2/VAPB/NUP62/DNALI1/SLC1A2/NRG4/MAP2K6/NCBP1/NDUFS1/DCTN2/NUP210/DCTN5/NUP107/PPP3CB/DCTN1/NUP160/NUP153/GPX7	6.52408836814065
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	48/1368	142/9376	2.31677786014332	UBE2S/CDC20/RPS27A/UBE2L3/SAE1/UBE2E3/UBE2C/UBA2/UBE2F/ANAPC5/UBA1/UBE2D3/UBE2M/CBLB/UBE2D2/RNF7/DDB1/UBR5/RCHY1/CUL3/CDC27/UBE2G1/UBE2K/ANAPC11/UBE2Z/CUL2/HERC3/UBE2J2/CUL1/CDC34/FBXW7/PRPF19/SKP2/HUWE1/UBE2G2/CDC16/UBE2O/UBE3A/ANAPC10/WWP1/TRIP12/UBE4A/CUL4A/CUL5/HERC4/ANAPC7/VHL/BIRC6	6.53474142578457
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	74/1368	268/9376	1.89246748712577	NDUFA4/UQCRH/CALM3/HSPA5/NDUFV3/TUBA1C/RPS27A/COX5A/CYC1/UQCRFS1/CYCS/NDUFS7/TXN2/NDUFA3/UBE2L3/CALM1/NDUFC1/SLC25A6/VDAC1/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/PARK7/NDUFA9/NDUFS2/SLC39A4/PSMA7/NDUFB9/KIF5B/PPIF/VDAC2/COX8C/NDUFC2/EIF2S1/NDUFA8/UBA1/COX6A1/UQCRC1/NDUFA12/SLC39A10/SDHA/VDAC3/PSMC4/NDUFS3/PSMD8/NDUFS4/NDUFB7/PSMC5/HTRA2/PSMD3/TUBB4B/PSMD12/SDHC/SDHB/UBE2G1/PSMD11/XBP1/SLC39A1/NDUFS8/GNAI1/PSMD6/GNAI3/UBE2J2/SDHD/SLC39A3/CASP3/MFN1/ERN1/ADCY5/UBE2G2/NDUFS1/SLC39A6	6.1265353578897
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	18/1368	31/9376	3.97962648556876	HSPA5/SPCS3/SRP9/SRP72/SEC11A/SEC11C/OXA1L/SRPRB/SEC61B/SEC61A1/SEC61G/IMMP1L/SGTA/SRP14/SEC63/UBL4A/SRP19/SRP68	6.86783218606849
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	49/1368	158/9376	2.1255459323414	CCNB1/CDC20/CCNE1/CCNB2/YWHAB/SMC1A/CCNA2/PTTG1/E2F5/AURKB/ANAPC5/BUB3/YWHAQ/DBF4/PLK1/PPP2R1A/MAD2L1/HDAC1/PPP2R5C/BUB1/TFDP1/RAD21/CDC14B/CDC27/HDAC2/CDKN1B/ANAPC11/CDC25C/ORC2/ATRX/CHEK2/MYC/NIPBL/CUL1/ORC4/NDC80/SKP2/PRKDC/PPP2R5E/CDC16/FBXO5/PPP2R1B/CDC25A/PDS5A/ANAPC10/PPP2R5A/PDS5B/CDC25B/ANAPC7	5.89712140874297
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	65/1368	235/9376	1.89573223839741	NDUFA4/ACTG1/UQCRH/RPS6/NDUFV3/COX5A/CYC1/UQCRFS1/NDUFS7/NDUFA3/NDUFC1/GRB2/NDUFS6/NDUFAF2/COX5B/NDUFA6/NDUFV2/COX7B/NDUFA9/NDUFAF4/NDUFS2/COA4/NDUFB9/COX8C/PPARG/NDUFC2/NDUFA8/COA1/COX6A1/UQCRC1/MAPK13/NDUFA12/SDHA/SMARCC1/SMARCA4/NDUFS3/NDUFS4/NDUFB7/RPS6KB2/COA6/SDHC/SDHB/NDUFAF1/NDUFS8/CPT1C/FGFR1/COA5/MAPK14/KDM1A/SDHD/SMARCB1/ACSL4/COX11/SMARCA2/AKT1S1/ADCY5/NDUFAF6/COA7/CREB1/NDUFS1/SMARCD2/RPS6KB1/DPF3/NRAS/NDUFAF7	5.74753912830613
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	35/1368	103/9376	2.32896156248226	RBM8A/PPP1CC/PAPOLA/PABPC4/PABPC1/ALYREF/PPP1CB/GSPT1/ETF1/DAZAP1/PNN/PPP2R1A/NCBP2/MSI2/PPP1CA/FUS/TARDBP/PPP2R5C/UPF3B/EIF4A3/PABPN1/FIP1L1/WDR33/CPSF6/ACIN1/MAGOHB/PPP2R5E/PPP2R1B/WDR82/UPF1/NCBP1/DDX39B/CPSF3/CSTF1/PPP2R5A	5.60515410252011
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	46/1368	157/9376	2.00812008790554	NDUFA4/UQCRH/LEP/NDUFV3/COX5A/CDC42/CYC1/UQCRFS1/CYCS/NDUFS7/NDUFA3/NDUFC1/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/NDUFA9/NDUFS2/NDUFB9/COX8C/PPARG/NDUFC2/EIF2S1/NDUFA8/COX6A1/UQCRC1/MAPK13/NDUFA12/SDHA/NDUFS3/NDUFS4/NDUFB7/MLX/SDHC/SDHB/XBP1/NDUFS8/MAPK14/SDHD/CASP3/AKT2/ERN1/NDUFS1/PIK3CB/ADIPOR2	5.26486017968362
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	75/1368	308/9376	1.66894508999772	NDUFA4/GPX3/UQCRH/NDUFV3/TUBA1C/COX5A/CYC1/UQCRFS1/CYCS/NDUFS7/NDUFA3/NDUFC1/SLC25A6/POLR2I/VDAC1/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/NDUFA9/NDUFS2/PSMA7/NDUFB9/KIF5B/PPIF/VDAC2/TFAM/COX8C/PPARG/NDUFC2/POLR2H/NDUFA8/TGM2/COX6A1/TAF4B/UQCRC1/NDUFA12/SDHA/VDAC3/PSMC4/HDAC1/NDUFS3/POLR2D/PSMD8/IFT57/POLR2E/NDUFS4/NDUFB7/PSMC5/PSMD3/TUBB4B/PSMD12/SDHC/SDHB/HDAC2/PSMD11/NDUFS8/REST/PSMD6/SDHD/POLR2A/TBPL1/CASP3/ERN1/AP2A1/DNALI1/SLC1A2/CREB1/NDUFS1/DCTN2/DCTN5/POLR2J3/DCTN1/GPX7	4.9337453215114
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	54/1368	205/9376	1.80539152759949	NDUFA4/GAPDH/UQCRH/NDUFV3/COX5A/MMP2/CYC1/PPP1CC/SLC2A1/UQCRFS1/NDUFS7/NDUFA3/NDUFC1/SLC25A6/VDAC1/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/NDUFA9/PPP1CB/NDUFS2/PDHB/NDUFB9/PPIF/VDAC2/COX8C/NDUFC2/NDUFA8/COX6A1/PDK3/UQCRC1/MAPK13/NDUFA12/SDHA/VDAC3/PPP1CA/NDUFS3/NDUFS4/PTEN/NDUFB7/PDHA1/SDHC/SDHB/NDUFS8/MAPK14/SDHD/ATP2A2/AKT2/G6PD/PRKCZ/NDUFS1/PIK3CB	4.81883765318066
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	40/1368	138/9376	1.98660903466395	NDUFA4/UQCRH/PPA1/NDUFV3/COX5A/CYC1/UQCRFS1/CYCS/NDUFS7/NDUFA3/NDUFC1/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/NDUFA9/NDUFS2/NDUFB9/COX8C/NDUFC2/NDUFA8/COX6A1/PPA2/UQCRC1/NDUFA12/SDHA/ATP6V0B/NDUFS3/NDUFS4/NDUFB7/SDHC/ATP6V0A4/SDHB/ATP6V1C2/NDUFS8/SDHD/ATP6V1A/COX11/NDUFS1	4.82572208369042
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	26/1368	75/9376	2.37598440545809	GAPDH/PHGDH/ENO1/PKM/TPI1/RPIA/TKT/PGAM1/IDH1/PGK1/ASL/IDH3G/CBS/ASNS/SHMT2/GPT2/CS/PRPS2/IDH3A/SHMT1/GOT1/MAT2A/IDH3B/ALDH18A1/ACO2/ACO1	4.9447686377118
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	12/1368	23/9376	3.57589626239512	ACAT2/ACAT1/HMGCR/IDI1/HMGCS1/MVD/NUS1/PDSS2/MVK/PDSS1/FNTA/ZMPSTE24	5.1119132414414
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	11/1368	20/9376	3.76959064327485	SQLE/FDFT1/MSMO1/EBP/LBR/TM7SF2/DHCR7/DHCR24/HSD17B7/CYP51A1/SC5D	5.12450745469573
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	14/1368	31/9376	3.09526504433126	ACAT2/MDH2/ACAT1/PCCA/PCCB/GCSH/DLD/SHMT2/CS/SHMT1/GLDC/ACO2/ACSS2/ACO1	4.82944046158042
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	25/1368	78/9376	2.19673114409957	ENO1/HSPD1/PABPC4/EXOSC8/PABPC1/EXOSC5/LSM7/DCPS/LSM4/EXOSC3/HSPA9/EXOSC7/NUDT16/LSM5/EXOSC2/EXOSC4/PNPT1/DCP1A/TOB2/DCP2/XRN2/CNOT7/EXOSC10/EXOSC9/ZCCHC7	4.3864762115923
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	14/1368	33/9376	2.9076732234627	IDH1/PDHB/IDH3G/DLD/GPT2/CS/DHTKD1/PDHA1/IDH3A/GOT1/IDH3B/ACO2/DLAT/ACO1	4.53716354590579
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/1368	85/9376	2.09645682834537	RRM2/IMPDH2/NME1/NT5C/AK2/ADSL/APRT/ADK/HDDC2/TK1/DTYMK/AK1/NT5C3B/NME2/GMPS/ITPA/NUDT16/NME6/NTPCR/ADA/UCK2/NME1-NME2/UCK1/AK5/IMPDH1/CANT1	4.19697540335519
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	99/1368	480/9376	1.41359649122807	NDUFA4/GPX3/UQCRH/CALM3/HSPA5/NDUFV3/TUBA1C/RPS27A/TOMM40/COX5A/CYC1/UQCRFS1/CYCS/NDUFS7/NDUFA3/UBE2L3/CALM1/NDUFC1/SLC25A6/VDAC1/MAP2K2/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/PARK7/HSD17B10/NDUFA9/NDUFS2/PSMA7/NDUFB9/KIF5B/PPIF/VDAC2/COX8C/NDUFC2/EIF2S1/NDUFA8/UBA1/COX6A1/PPID/UQCRC1/MAPK13/NDUFA12/CAPN1/SDHA/CSNK1A1/VDAC3/PSMC4/NDUFS3/FZD3/FUS/SIGMAR1/DVL3/PSMD8/TARDBP/IFT57/NDUFS4/NDUFB7/PSMC5/HTRA2/PSMD3/TUBB4B/PSMD12/SDHC/DERL1/SDHB/UBE2G1/FRAT2/PSMD11/XBP1/NDUFS8/PSMD6/DKK1/MAPK14/UBE2J2/SDHD/ATP2A2/WNT7A/CASP3/MFN1/CSNK1E/ERN1/CCS/VAPB/UBE2G2/BAK1/DNALI1/MAP2K6/NDUFS1/DCTN2/DCTN5/PPP3CB/LRP5/BRAF/DCTN1/GPX7/NRAS	3.8447378393283
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	19/1368	56/9376	2.32539682539683	OSTC/MAN1A2/STT3B/DHRSX/GANAB/ALG3/SRD5A3/MAN2A1/ALG8/STT3A/MAGT1/DOLPP1/B4GALT3/ALG6/DOLK/ALG2/ALG14/DPAGT1/MOGS	4.11148431703076
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	36/1368	138/9376	1.78794813119756	CCNB1/CDC20/CCNE1/CALM3/CCNB2/PPP1CC/AURKA/CALM1/YWHAB/SMC1A/PTTG1/PPP1CB/ANAPC5/YWHAQ/MAPK13/PLK1/PPP2R1A/PPP1CA/MAD2L1/PPP2R5C/BUB1/CDC27/ANAPC11/MAPK14/CDC25C/CUL1/ADCY5/PPP2R5E/CDC16/FBXO5/PPP2R1B/ANAPC10/PPP3CB/PPP2R5A/IGF1/ANAPC7	3.85402785087792
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	81/1368	388/9376	1.43081931633207	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	3.58216967300947
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	61/1368	275/9376	1.52029771398192	NDUFA4/UQCRH/CAV1/HSPA5/NDUFV3/TUBA1C/COX5A/STIP1/CYC1/UQCRFS1/CYCS/NDUFS7/HSPA8/NDUFA3/NDUFC1/SLC25A6/VDAC1/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/NDUFA9/NDUFS2/PSMA7/NDUFB9/KIF5B/PPIF/VDAC2/COX8C/NDUFC2/EIF2S1/NDUFA8/COX6A1/UQCRC1/MAPK13/NDUFA12/SDHA/VDAC3/PSMC4/NDUFS3/PSMD8/NDUFS4/NDUFB7/PSMC5/PSMD3/TUBB4B/PSMD12/SDHC/SDHB/PSMD11/NDUFS8/PSMD6/MAPK14/SDHD/CASP3/LAMC1/CREB1/NDUFS1/PPP3CB/PIK3CB	3.6194315032656
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/1368	227/9376	1.57003374810006	NDUFA4/UQCRH/NDUFV3/COX5A/CYC1/MGST3/UQCRFS1/NDUFS7/ACP1/NDUFA3/NDUFC1/MGST1/SLC25A6/VDAC1/MAP2K2/CBR1/GSTA4/GRB2/NDUFS6/COX5B/NDUFA6/NDUFV2/COX7B/NDUFA9/NDUFS2/NDUFB9/PPIF/VDAC2/COX8C/NDUFC2/NDUFA8/COX6A1/UQCRC1/MAPK13/NDUFA12/SDHA/VDAC3/NDUFS3/NDUFS4/PTEN/NDUFB7/SDHC/SDHB/NDUFS8/MAPK14/SDHD/AKT2/NDUFS1/SLC26A6/BRAF/PIK3CB/NRAS	3.59329884428337
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	31/1368	117/9376	1.81596441245564	ACTG1/ACTR6/RUVBL1/BPTF/SMARCC1/HDAC1/SMARCA4/MTA3/RUVBL2/GATAD2A/BAZ1B/MCRS1/HDAC2/UCHL5/SS18/NFRKB/CHRAC1/MBD3/MTA1/SMARCB1/SMARCA2/BRD9/MBD2/EPC1/CHD4/INO80/CDK2AP1/SMARCD2/MRGBP/DPF3/DMAP1	3.67069889680261
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	33/1368	128/9376	1.76699561403509	RRM2/IMPDH2/NME1/NT5C/AK2/ADSL/APRT/ADK/HDDC2/PAICS/AK1/ATIC/NME2/GMPS/ITPA/PDE4D/NUDT16/NME6/NTPCR/ADA/PGM1/PRPS2/GART/ADCY5/NME1-NME2/NUDT9/PPAT/HDDC3/AK5/IMPDH1/PDE6H/PAPSS1/CANT1	3.61110909809232
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	16/1368	47/9376	2.33320890879681	LDHA/PKM/ACAT2/MDH2/ACAT1/PDHB/DLD/ADH5/PDHA1/FH/GLO1/ACACA/ACSS2/ALDH3A2/DLAT/ALDH9A1	3.78700818811966
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/1368	39/9376	2.46033888139151	AHCY/ATIC/MTHFD1L/GCSH/DLD/CBS/SHMT2/AHCYL1/SHMT1/MAT2A/GART/GLDC/MTHFD2L/MTHFD1	3.77701689242273
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/1368	57/9376	2.16435826408126	ACAT2/ACAT1/HSD17B12/ELOVL1/ELOVL6/ACAA1/SCD/FASN/CPT1C/CBR4/ACACA/HADH/ACSL4/ELOVL5/FADS1/PPT2/MECR/MCAT	3.64423232918179
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	20/1368	67/9376	2.04591079689273	LDHA/GAPDH/ENO1/PKM/TPI1/PGAM1/GPI/PGK1/PDHB/G6PC3/HK1/DLD/ADH5/PDHA1/PGM1/ACSS2/ALDH3A2/DLAT/ALDH3B2/ALDH9A1	3.55097150326194
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	20/1368	71/9376	1.9306482167861	LDHA/PKM/SLC2A1/SLC16A3/PGAM1/IDH1/MAP2K2/SLC1A5/PDHB/HK1/PTEN/PDHA1/FGFR1/MYC/AKT2/PDK1/SCO2/G6PD/PIK3CB/NRAS	3.25329308302964
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	8/1368	19/9376	2.88581101877501	PDHB/GCSH/DLD/LIAS/DHTKD1/PDHA1/GLDC/DLAT	3.40073905804817
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	16/1368	54/9376	2.03075590210093	LDHA/SRM/PHGDH/AHCY/MDH2/MPST/TST/ADI1/AMD1/DNMT3B/CBS/AHCYL1/GOT1/MAT2A/MTAP/MRI1	3.13953128800764
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	27/1368	110/9376	1.6822966507177	CCNB1/HSP90AB1/CCNB2/AURKA/HSP90AA1/CCNA2/ANAPC5/MAPK13/PLK1/MAD2L1/BUB1/CDC27/ANAPC11/GNAI1/MAPK14/GNAI3/CDC25C/AKT2/ADCY5/CDC16/CDC25A/ANAPC10/BRAF/PIK3CB/CDC25B/IGF1/ANAPC7	2.97502136336942
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	29/1368	122/9376	1.62918224523056	LEP/EEF2/HMGCR/CCNA2/PPARG/EIF4EBP1/G6PC3/PPP2R1A/RAB10/CAB39L/SCD/PPP2R5C/RPS6KB2/FASN/CPT1C/ACACA/ELAVL1/AKT2/AKT1S1/PPP2R5E/PPP2R1B/CREB1/EEF2K/RPS6KB1/PFKFB4/PPP2R5A/PIK3CB/IGF1/ADIPOR2	2.89106783062224
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	14/1368	48/9376	1.9990253411306	ACAT2/ACAT1/HSD17B10/MCCC2/PCCA/PCCB/HMGCS1/DLD/ACAA1/HADH/IVD/ALDH3A2/HIBADH/ALDH9A1	2.8679363548425
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	5/1368	10/9376	3.42690058479532	MPST/TST/SELENBP1/SUOX/PAPSS1	3.17352237199066
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	34/1368	157/9376	1.48426267366931	HLA-G/CCNB1/CCNE1/CALM3/HLA-C/CCNB2/PPP1CC/CALM1/SLC25A6/VDAC1/MAP2K2/CCNA2/PPP1CB/E2F5/VDAC2/EIF4EBP1/PPID/MAPK13/CAPN1/VDAC3/PPP1CA/PTEN/MAPK14/HUS1/CHEK2/MYC/AKT2/MAP2K6/CDC25A/FOXM1/PPP3CB/PIK3CB/TRPM7/NRAS	2.52903924611368
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	33/1368	154/9376	1.468671679198	NME1/AK2/ADSL/UROS/ALAS2/AK1/HMBS/MTHFD1L/NME2/RDH11/GGCX/DLD/SHMT2/NME6/LIAS/MMAB/PANK3/VKORC1L1/SHMT1/COQ2/MAT2A/ALAS1/GUSB/NME1-NME2/MTHFD2L/NADK/UGDH/TPK1/COQ3/ALDH3A2/AK5/FLAD1/MTHFD1	2.423724020512
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	38/1368	183/9376	1.42319368548877	RAN/FBL/RRP7A/IMP4/GNL3/NOP56/DKC1/NOP58/WDR43/XPO1/GAR1/RBM28/EMG1/MPHOSPH10/GTPBP4/NOP10/NOB1/UTP6/NHP2/NMD3/WDR36/UTP14A/RPP25L/XRN2/RPP38/RPP40/MDN1/POP5/GNL2/WDR3/WDR75/HEATR1/NVL/LSG1/PWP2/TCOF1/UTP14C/BMS1	2.38947641586768
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1368	110/9376	1.55768208399787	LDHA/GAPDH/ENO1/RPS6/SLC2A1/EGLN3/MAP2K2/PGK1/PDHB/EIF4EBP1/HK1/EIF4E/RPS6KB2/PDHA1/CDKN1B/MKNK1/CUL2/AKT2/TFRC/PDK1/EGLN1/RPS6KB1/PIK3CB/IGF1/VHL	2.43166386954537
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	30/1368	138/9376	1.48995677599797	PYGL/RPS6/CALM3/PPP1CC/CALM1/MAP2K2/GRB2/PPP1CB/EIF4EBP1/G6PC3/HK1/PPP1CA/EIF4E/CBLB/SH2B2/RPS6KB2/FASN/MKNK1/CRK/ACACA/PRKAR1A/AKT2/PRKAR2A/PRKCZ/INPP5A/PPP1R3B/RPS6KB1/BRAF/PIK3CB/NRAS	2.39648650165916
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	6/1368	15/9376	2.74152046783626	AK2/ACP1/AK1/NTPCR/TPK1/AK5	2.78984287662482
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/1368	28/9376	2.20300751879699	HSD17B12/THEM4/ELOVL1/ELOVL6/ACOT4/HADH/ELOVL5/PPT2/MECR	2.63484250098135
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	18/1368	73/9376	1.68997837058399	RAN/CHMP4A/PPIA/XPO1/NELFCD/PIN1/NELFE/TNPO3/CPSF6/CHMP6/SMARCB1/FURIN/NELFB/BICD2/CCNT1/NELFA/NUP153/CCNT2	2.44597520887874
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1368	59/9376	1.74249182277728	GPX3/SRM/RRM2/MGST3/MGST1/IDH1/GSTA4/ODC1/TXNDC12/ANPEP/PGD/G6PD/GGT7/GPX7/LANCL1	2.36453794504
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1368	34/9376	2.01582387340901	POLR2I/POLR2H/POLR1D/POLR2D/POLR2E/POLR1E/POLR2A/POLR3H/POLR3G/POLR2J3	2.45247504475674
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/1368	41/9376	1.83882470403651	PHGDH/PGAM1/ALAS2/GCSH/DLD/CBS/SHMT2/GCAT/SHMT1/ALAS1/GLDC	2.22470604132189
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/1368	27/9376	2.03075590210093	HSD17B12/ELOVL1/ELOVL6/ACOT4/ACAA1/SCD/ELOVL5/FADS1	2.21677587850313
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	15/1368	63/9376	1.63185742133111	ACAT2/ACAT1/HYKK/GCDH/DLD/DHTKD1/PLOD1/HADH/SETD2/KMT2B/AASS/ALDH3A2/ASH1L/CAMKMT/ALDH9A1	2.07975041037602
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1368	42/9376	1.79504316346422	SLC3A2/PCBP2/VDAC2/CP/VDAC3/SLC7A11/ATG5/SAT2/ACSL4/NCOA4/TFRC	2.13426385315348
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	9/1368	32/9376	1.92763157894737	LDHA/PCCA/PCCB/SUCLG2/DLD/ACACA/SUCLA2/ECHDC1/ACSS2	2.1724548217102
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	26/1368	125/9376	1.42559064327485	MAP2K2/RHOA/MAPK13/PPP2R1A/ORMDL2/PPP2R5C/PTEN/CERS4/SGPP1/GNA12/GNAI1/MAPK14/GNAI3/SMPD2/AKT2/CERS5/PPP2R5E/SPTLC1/S1PR1/PRKCZ/PPP2R1B/RAC3/PPP2R5A/PIK3CB/S1PR3/NRAS	1.9797912112756
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1368	18/9376	2.28460038986355	FASN/CBR4/ACACA/ACSL4/MECR/MCAT	2.25465156994616
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/1368	59/9376	1.6263257012588	RRM2/NME1/NT5C/HDDC2/TK1/DTYMK/NT5C3B/NME2/NME6/UCK2/NME1-NME2/CDADC1/UCK1/CANT1	1.99459555128925
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	16/1368	70/9376	1.56658312447786	CDC42/SLC2A1/EGLN3/MAP2K2/GRB2/FH/CRK/CUL2/PRCC/AKT2/EGLN1/PAK4/BRAF/PIK3CB/NRAS/VHL	1.9665173644275
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	18/1368	83/9376	1.4863665187064	AURKB/UBE2D3/HDAC1/UBE2D2/SUZ12/WDR5/TFDP1/HDAC2/PCGF6/DCAF7/RNF2/MTF2/RYBP/L3MBTL2/PCGF3/FBRSL1/HCFC1/FOXK2	1.83946446667421
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/1368	50/9376	1.64491228070175	SRM/ODC1/AMD1/CNDP2/OAT/CKMT1A/SAT2/GOT1/ALDH18A1/CKB/ALDH3A2/ALDH9A1	1.88975106299554
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1368	51/9376	1.61265909872721	ACTG1/KDELR2/KDELR1/PDIA4/SEC61B/ATP6V0B/SEC61A1/SEC61G/ATP6V0A4/ATP6V1C2/ATP6V1A/KDELR3	1.81320208656904
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1368	62/9376	1.54763252216563	HSPA8/CLPB/CRYAB/HDAC1/RPS6KB2/HDAC2/ATG5/AKT2/AKT1S1/ADCY5/RPS6KB1/PIK3CB/IGF1/NRAS	1.78806628426585
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1368	31/9376	1.768722882475	RPIA/TKT/PGLS/GPI/PGM1/PRPS2/PGD/G6PD	1.77185287484831
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	30/1368	158/9376	1.30135465245392	RPS6/EIF4B/MAP2K2/GRB2/SLC3A2/EIF4EBP1/RHOA/EIF4E/CAB39L/FZD3/SEH1L/DVL3/PTEN/RPS6KB2/SEC13/ATP6V1C2/LAMTOR1/SLC38A9/ATP6V1A/WNT7A/AKT2/AKT1S1/SKP2/RPS6KB1/LRP5/BRAF/PIK3CB/RICTOR/IGF1/NRAS	1.57890044426127
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/1368	87/9376	1.41802782819117	CYCS/BIRC5/MAP2K2/GRB2/RHOA/RPS6KB2/RALA/MYC/CASP3/AKT2/MSH3/BAK1/RALB/RAC3/RPS6KB1/BRAF/PIK3CB/NRAS	1.61900053896147
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1368	37/9376	1.66714082503556	ADSL/ASL/ASNS/GPT2/RIMKLB/GOT1/ASRGL1/PPAT/GLUD1	1.68048579854584
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	17/1368	82/9376	1.42090999857367	RRM2/IMPDH2/NME1/MGST3/MGST1/GSTA4/TK1/NME2/GMPS/ITPA/NME6/GUSB/UCK2/NME1-NME2/CDADC1/UCK1/IMPDH1	1.58220039705868
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1368	12/9376	2.28460038986355	GGCX/VKORC1L1/COQ2/COQ3	1.84032541862798
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1368	43/9376	1.59390724874201	ACAT2/ACAT1/GCDH/ACAA1/ADH5/CPT1C/HADH/ACSL4/ALDH3A2/ALDH9A1	1.6132767519923
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	40/1368	224/9376	1.22389306599833	HLA-G/RAN/CDC20/CCNE1/HLA-C/CCNB2/SLC2A1/RANBP1/SLC25A6/VDAC1/MAP2K2/CALR/CCNA2/PTTG1/CANX/VDAC2/XPO1/ANAPC5/BUB3/VDAC3/MAD2L1/NFYB/PTEN/IL1R1/CDC27/ANAPC11/CHEK2/TBPL1/MYC/AKT2/ADCY5/CDC16/CREB1/ANAPC10/PPP3CB/PIK3CB/CRTC3/NRAS/ANAPC7/DLG1	1.40175883394324
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1368	44/9376	1.55768208399787	OSTC/MAN1A2/STT3B/ALG3/MAN2A1/STT3A/MAGT1/B4GALT3/ALG2/ALG14	1.53247119642521
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1368	44/9376	1.55768208399787	TAF9/TAF4B/GTF2H3/TAF12/TBPL1/GTF2F2/GTF2F1/TAF8/TAF1/ERCC2	1.53247119642521
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	42/1368	238/9376	1.20949432404541	RPS9/RPL29/RPL7A/RPL18A/RPL28/RPL19/RPSA/RPL5/RPL36/RPS3A/RPS5/RPS15/RPL15/RPL8/RPS13/RPS6/RPLP0/RPS18/RPL6/RPS4X/RPS27A/RPL14/RPL3/RPL13A/RPL35A/RPS7/RPL22L1/RPL22/RPL4/CFD/RPL10/RPL11/RPS26/RPL37A/RSL24D1/MAPK13/C1R/RPL26L1/MAPK14/IRAK1/PIK3CB/C1S	1.35301252579309
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1368	18/9376	1.90383365821962	MMADHC/MMAB/CD320/ABCD4/HCFC1	1.58635322903142
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/1368	68/9376	1.41107671138631	MAP2K2/CCNA2/GRB2/EIF4EBP1/RPS6KB2/JUP/PPARD/MYC/AKT2/DUSP6/RPS6KB1/BRAF/PIK3CB/NRAS	1.40609866924241
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1368	63/9376	1.41427643182029	POLR2I/POLD2/POLR2H/GTF2H3/POLR2D/POLE4/DDB1/POLR2E/POLR2A/RFC5/POLR2J3/CUL4A/ERCC2	1.36358543874074
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1368	75/9376	1.37076023391813	CCNB1/CCNE1/RRM2/CCNB2/CYCS/EI24/SHISA5/GTSE1/PTEN/SIVA1/CCNG1/RCHY1/CHEK2/CASP3/IGF1	1.33237235067261
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/1368	46/9376	1.48995677599797	PSMA7/PSMC4/PSMD8/PSMC5/PSMF1/PSMD3/PSMD12/PSMD11/PSMD6/PSME3	1.37677355936645
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1368	93/9376	1.32654216185625	CCNE1/CYCS/LAMA1/TRAF4/LAMA4/PTEN/ITGAV/LAMB1/CDKN1B/MYC/CASP3/LAMC1/AKT2/ITGA6/SKP2/BAK1/LAMA5/PIK3CB	1.3079863668434
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1368	37/9376	1.48190295558717	GPI/NAGK/HK1/PGM3/PGM1/GNPNAT1/UGDH/GNE	1.21388325035922
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1368	109/9376	1.25757819625516	PYGL/PPP1CC/SLC2A1/PPP1CB/SLC27A2/G6PC3/PPP1CA/SLC27A5/PTEN/RPS6KB2/MLX/AKT2/NR1H2/PRKCZ/CREB1/PPP1R3B/RPS6KB1/TRIB3/PIK3CB/SLC27A6	1.11794237909466
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1368	110/9376	1.2461456671983	ID1/BMP4/ID3/ID2/E2F5/RHOA/PPP2R1A/HDAC1/RPS6KB2/TFDP1/TGIF2/HDAC2/ID4/MYC/LRRC32/CUL1/TFRC/ACVR2B/PPP2R1B/RPS6KB1	1.07327013498523
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1368	38/9376	1.4429055093875	GPI/NAGK/HK1/PGM3/PGM1/GNPNAT1/UGDH/GNE	1.13068752547405
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1368	21/9376	1.63185742133111	CHST12/CHSY1/DSEL/B4GALT7/XYLT1	1.19804600933208
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/1368	44/9376	1.40191387559809	APEX1/NTHL1/POLD2/SMUG1/POLE4/LIG3/TDP1/PNKP/RFC5	1.10443110056955
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	14/1368	75/9376	1.27937621832359	MGST3/CYCS/MGST1/BIRC5/GSTA4/TOP2A/TOP2B/SLC31A1/CASP3/AKT2/MSH3/BAK1/REV3L/PIK3CB	1.00397268821451
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	36/1368	214/9376	1.15297589768815	HLA-G/CCNB1/CALM3/HLA-C/CCNB2/CYCS/CALM1/MAP2K2/CALR/GNB2/MAPK13/CFL2/PDIA3/RNF7/DDB1/RPS6KB2/GNAI1/CRK/MAPK14/GNAI3/CDC25C/AP1S1/CASP3/AKT2/CUL1/IRAK1/BAK1/PAK4/MAP2K6/RAC3/RPS6KB1/PPP3CB/PIK3CB/CUL4A/CUL5/NRAS	0.935624117387685
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	41/1368	248/9376	1.13308809658555	DYNLL1/GAPDH/ACTG1/HSP90AB1/TUBA1C/CDC42/CYCS/TXN2/HSP90B1/HSP90AA1/PYCARD/MAP2K2/KIF5B/RHOA/MAPK13/ACTR2/CSE1L/ARPC4/TUBB4B/RALA/BRK1/FBXO22/MAPK14/DYNC1LI1/MYC/CASP3/AKT2/KPNA4/RAB7A/IRAK1/BAK1/MAP2K6/PIK3C2G/PIK3C2A/MYL5/DCTN2/VPS33A/DCTN5/PIK3CB/DCTN1/GSDMD	0.877897663629928
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/1368	52/9376	1.31803868645974	VDAC1/VDAC2/VDAC3/SORT1/LRP2/LDLR/PLTP/VAPB/STARD3NL/LDLRAP1	0.950489109434845
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1368	83/9376	1.23863876558867	IDH1/PXMP4/SLC27A2/MPV17L2/ACAA1/CRAT/MVK/ABCD3/PEX19/ACSL4/PEX13/PECR/PEX16/AGPS/ABCD4	0.902544712244754
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/1368	142/9376	1.15838893007166	ACTG1/CAV1/HSP90AB1/CALM3/MMP2/MGST3/TXN2/CALM1/BMP4/MGST1/HSP90B1/HSP90AA1/GSTA4/RHOA/MAPK13/IL1R1/ITGAV/MAPK14/AKT2/ACVR2B/MAP2K6/PRKCZ/RAC3/PIK3CB	0.786032886832034
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/1368	149/9376	1.14996663919306	NDUFA4/NDUFV3/NDUFS7/NDUFA3/NDUFC1/NDUFS6/NDUFA6/NDUFV2/NDUFA9/NDUFS2/NDUFB9/GNB2/NDUFC2/NDUFA8/MAPK13/NDUFA12/NDUFS3/NDUFS4/NDUFB7/NDUFS8/GNAI1/MAPK14/GNAI3/ADCY5/NDUFS1	0.762648090884632
NA	NA	hsa03272	Virion - Hepatitis viruses	9/1368	48/9376	1.28508771929825	CLDN10/EPCAM/CLDN6/CLDN3/CLDN7/CHMP4A/CLDN4/LDLR/CHMP7	0.818411106137981
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1368	42/9376	1.30548593706488	ACAT2/ACAT1/GCDH/DLD/DHTKD1/HADH/ALDH3A2/ALDH9A1	0.820065655660023
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/1368	36/9376	1.33268356075374	SSBP1/RNASEH2C/POLD2/RNASEH1/POLE4/RFC5/POLA2	0.826562709389537
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1368	24/9376	1.42787524366472	EXTL2/HS6ST2/HS3ST3B1/B4GALT7/XYLT1	0.867435488260003
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1368	30/9376	1.37076023391813	PIGF/GPAA1/PGAP1/PIGG/PIGH/PIGT	0.840635141652344
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1368	30/9376	1.37076023391813	ABCG2/SLC19A1/ATIC/SHMT2/SHMT1/GART	0.840635141652344
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1368	86/9376	1.19543043655651	MAP2K2/GRB2/EIF4EBP1/CBLB/RPS6KB2/CDKN1B/CRK/MYC/AKT2/NRG4/PAK4/RPS6KB1/BRAF/PIK3CB/NRAS	0.752489120793147
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	24/1368	144/9376	1.14230019493177	ID1/BMP4/ID3/MAP2K2/GRB2/ID2/MAPK13/TBX3/DLX5/FZD3/DVL3/ID4/PCGF6/FGFR1/REST/MAPK14/WNT7A/MYC/AKT2/ACVR2B/PCGF3/PIK3CB/IGF1/NRAS	0.711222517081546
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	24/1368	144/9376	1.14230019493177	CYCS/SLC25A6/VDAC1/NOP56/PSMA7/PPIF/VDAC2/VDAC3/PSMC4/PSMD8/PSMC5/PSMD3/PSMD12/PSMD11/XBP1/PSMD6/ATXN10/ATP2A2/TBPL1/AKT2/ERN1/OPA1/AFG3L2/PIK3CB	0.711222517081546
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	28/1368	170/9376	1.12886136910905	ACTG1/MGST3/MGST1/MAP2K2/GSTA4/GRB2/CSNK1A1/SMARCC1/SMARCA4/FZD3/DVL3/PTEN/RPS6KB2/FRAT2/SMARCB1/WNT7A/MYC/AKT2/SMARCA2/BAK1/TXNRD1/SMARCD2/RPS6KB1/LRP5/BRAF/PIK3CB/DPF3/NRAS	0.700774630910963
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1368	80/9376	1.19941520467836	RPS6/MAP2K2/GRB2/EIF4EBP1/EIF4E/PTEN/RPS6KB2/NF1/AKT2/RPS6KB1/BRAF/PIK3CB/IGF1/NRAS	0.740324052089222
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/1368	87/9376	1.18168985682597	UQCRH/COX5A/CYC1/UQCRFS1/TPM2/MYL4/COX5B/COX7B/FXYD2/COX8C/COX6A1/ATP1A1/UQCRC1/ATP2A2/SLC9A1	0.703675583986632
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	33/1368	204/9376	1.10870313037496	ACTG1/CAV1/RPS6/CDC42/MMP2/PPP1CC/EIF4B/MAP2K2/GRB2/PPP1CB/RHOA/MAPK13/PPP1CA/FZD3/IQGAP1/DDX5/RPS6KB2/ITGAV/FGFR1/MAPK14/ANK3/WNT7A/MYC/CASP3/AKT2/PPP1R12A/NUDT16L1/SLC9A1/RPS6KB1/BRAF/PIK3CB/IGF1/NRAS	0.648771504132898
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/1368	37/9376	1.29666508613877	COMT/GSTZ1/ADH5/MIF/GOT1/FAH/ALDH3B2	0.747280702172601
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1368	37/9376	1.29666508613877	MAP2K2/PPARG/NCOA4/MYC/BAK1/BRAF/NRAS	0.747280702172601
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1368	13/9376	1.58164642375169	XRCC5/XRCC6/PRKDC	0.867341009839576
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	22/1368	133/9376	1.13371147166161	CCNB1/CCNB2/BNIP3/PRMT1/MAP2K2/GRB2/MAPK13/G6PC3/PLK1/ATG12/PTEN/CDKN1B/MAPK14/AKT2/CSNK1E/SGK2/SKP2/S1PR1/BRAF/PIK3CB/IGF1/NRAS	0.641881217066897
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	33/1368	205/9376	1.10329482242191	HLA-G/CDC20/CCNE1/HLA-C/PKM/CDC42/YWHAB/RANBP1/CCNA2/GRB2/YWHAQ/RHOA/DDX3X/VDAC3/HDAC1/GTF2H3/HNRNPK/DDB1/MRPS18B/HDAC2/CDKN1B/TBPL1/CASP3/SKP2/CHD4/BAK1/CREB1/UBE3A/PIK3CB/HDAC3/NRAS/DNAJA3/DLG1	0.618036026712257
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/1368	82/9376	1.17016117529596	HLA-G/HSP90AB1/HLA-C/HSPA5/HSPA8/HSP90AA1/CALR/CANX/HSPA4/PDIA3/NFYB/RFXANK/PSME3/CREB1	0.639635741677739
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/1368	44/9376	1.2461456671983	DYNLL1/ARHGDIA/DYNC1LI1/NSF/CREB1/DCTN2/DCTN5/DCTN1	0.676391004713894
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	29/1368	180/9376	1.10422352176738	HLA-G/HLA-C/PPP1CC/SRSF3/CYCS/CALR/SRSF2/SRSF9/ALYREF/PPP1CB/SRSF7/SRPK1/SRSF1/EIF2S1/SRSF4/EIF4EBP1/SRSF5/PPP1CA/PDIA3/SRSF6/EIF2B2/CASP3/AKT2/EIF2B5/IRAK1/BAK1/PIK3CB/HCFC1/EIF2B4	0.583538036900571
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/1368	154/9376	1.11263005999848	CALM3/PPP1CC/TPM2/CALM1/MYL4/PPP1CB/FXYD2/ATP1A1/MAPK13/PPP2R1A/PPP1CA/PPP2R5C/GNAI1/MAPK14/GNAI3/ATP2A2/AKT2/ADCY5/ATP2B1/PPP2R5E/PPP2R1B/CREB1/SLC9A1/PPP2R5A/ATP2B4	0.582463575177328
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/1368	70/9376	1.1749373433584	HLA-G/ACTG1/CAV1/HLA-C/CYCS/CD55/LAMA1/DAG1/EIF4G1/EIF4G2/CASP3/RAC3	0.607178909040281
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1368	32/9376	1.28508771929825	CYCS/BIRC5/HTRA2/CASP3/BAK1/BIRC6	0.667657510218264
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	19/1368	116/9376	1.12260536398467	CLDN10/ACTG1/CDC42/MMP2/CLDN6/CLDN3/CLDN7/CLDN4/JAM3/RHOA/MAPK13/VCL/GNAI1/MAPK14/GNAI3/THY1/CTNND1/MYL5/PIK3CB	0.549160923784473
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/1368	77/9376	1.15713526239842	MAP2K2/GRB2/HDAC1/HDAC2/CDKN1B/CRK/MYC/CTBP2/AKT2/BAK1/BRAF/PIK3CB/NRAS	0.572225949547172
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1368	52/9376	1.18623481781377	CGA/CYP11A1/CYP2J2/ACOT4/HSD3B1/LDLR/ADCY5/HSD17B7/IGF1	0.556580610050956
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/1368	78/9376	1.14230019493177	CALM3/CALM1/PYCARD/RHOA/MAPK13/CFL2/C1R/GNAI1/MAPK14/GNAI3/CASP3/IRAK1/C1S	0.521584503796654
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/1368	112/9376	1.1015037593985	CYCS/HSPA8/LAMA1/PPIF/MAPK13/LAMA4/LDLR/LAMB1/GNAI1/MAPK14/GNAI3/CASP3/LAMC1/AKT2/ITGA6/IRAK1/MAP2K6/LAMA5	0.446640931226097
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	16/1368	99/9376	1.1076850375096	MMP2/MAP2K2/GRB2/MAPK13/RPS6KB2/CDKN1B/MAPK14/AKT2/ADCY5/CARM1/DLL1/RPS6KB1/BRAF/PIK3CB/IGF1/NRAS	0.445180196998769
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/1368	106/9376	1.0991945271985	CCNE1/HSP90AB1/ETV5/HSP90B1/HSP90AA1/MAP2K2/GRB2/SLC19A1/PTEN/CDKN1B/FGFR1/AKT2/CREB1/BRAF/PIK3CB/IGF1/NRAS	0.424489968944392
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	26/1368	166/9376	1.07348693017685	CALM3/PPP1CC/CALM1/SLC25A6/VDAC1/MAP2K2/PPP1CB/FXYD2/PPIF/VDAC2/RHOA/ATP1A1/VDAC3/PPP1CA/GNA12/GNAI1/GNAI3/ATP2A2/AKT2/PPP1R12A/ADCY5/EDNRB/ATP2B1/CREB1/PPP3CB/ATP2B4	0.394821677361886
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	21/1368	133/9376	1.08217913204063	CALM3/PPP1CC/COMT/CALM1/PPP1CB/KIF5B/GNB2/MAPK13/PPP2R1A/PPP1CA/PPP2R5C/GNAI1/MAPK14/GNAI3/AKT2/ADCY5/PPP2R5E/PPP2R1B/CREB1/PPP3CB/PPP2R5A	0.394500491515301
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1368	22/9376	1.2461456671983	CNDP2/ALDH3A2/ALDH3B2/ALDH9A1	0.477717892550695
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1368	75/9376	1.0966081871345	CGA/GPX3/HSPA5/HSP90B1/CANX/PDIA4/FXYD2/ATP1A1/LRP2/ADCY5/CREB1/GPX7	0.34717336329829
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	19/1368	122/9376	1.06739526411658	CDC42/MAP2K2/GRB2/RHOA/MAPK13/PPP2R1A/CBLB/PPP2R5C/MAP3K8/MAPK14/AKT2/PPP2R5E/PAK4/PPP2R1B/PPP3CB/PPP2R5A/PIK3CB/NRAS/DLG1	0.309678605047606
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	19/1368	122/9376	1.06739526411658	ACTG1/SLC2A1/BMP4/MAP2K2/FXYD2/ATP1A1/HDAC1/ITGAV/HDAC2/MED30/MED12L/ATP2A2/MYC/AKT2/MED27/SLC9A1/PIK3CB/HDAC3/NRAS	0.309678605047606
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/1368	250/9376	1.04177777777778	HLA-G/CAV1/HLA-C/CDC42/HSPA8/SPG21/SNF8/CHMP4A/VPS28/KIF5B/VPS25/RHOA/ACTR2/RAB10/CBLB/SNX5/SNX6/ARPC4/MVB12A/ARFGAP2/VPS26A/LDLR/VPS36/RAB4A/ARF3/CHMP6/VPS29/EPS15L1/TFRC/RAB7A/AP2A1/PRKCZ/CHMP7/SH3GL3/WWP1/EPN1/RNF41/LDLRAP1	0.276720773053055
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1368	16/9376	1.28508771929825	MIF/GOT1/ALDH3B2	0.471701471720548
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1368	36/9376	1.14230019493177	PYGL/GPI/GYG2/G6PC3/HK1/PGM1	0.35354928389904
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/1368	56/9376	1.1015037593985	HSPD1/CYCS/BNIP3/HSPA8/PYCARD/SAR1A/SAR1B/CASP3/RAB1B	0.314872577698857
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/1368	157/9376	1.04771482847245	SLC16A1/SLC2A1/UQCRFS1/MAP2K2/CALR/BSG/XKR8/ODC1/PPARG/MAPK13/ATP11B/DUSP5/ITGAV/CPT1C/CRK/MAPK14/ATP2A2/PPARD/CASP3/NR1H2/RAB7A/S1PR1/CREB1/VPS33A	0.24918846813873
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1368	23/9376	1.19196542079837	ASL/GPT2/GOT1/GLUD1	0.380958888292198
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1368	23/9376	1.19196542079837	SSBP1/POLD2/MSH3/RFC5	0.380958888292198
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1368	23/9376	1.19196542079837	ANPEP/ENPEP/THOP1/NLN	0.380958888292198
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1368	23/9376	1.19196542079837	FXYD2/ATP1A1/CA2/GLUD1	0.380958888292198
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/1368	90/9376	1.06614684860299	PPARG/EIF4EBP1/EIF4E/RPS6KB2/ATG5/AKT2/AKT1S1/ADCY5/CREB1/RPS6KB1/PIK3CB/IGF1/NRAS/ADIPOR2	0.260604990396317
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1368	17/9376	1.20949432404541	SEPHS1/TXNRD1/PAPSS1	0.357312864484474
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1368	17/9376	1.20949432404541	CA2/CA12/GLUD1	0.357312864484474
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	30/1368	200/9376	1.0280701754386	CLDN10/GAPDH/ACTG1/TUBA1C/TMBIM6/CDC42/CYCS/CLDN6/CLDN3/NCL/PYCARD/MYO1B/CLDN7/CLDN4/TMED10/MYO10/RHOA/MAPK13/ACTR2/ARPC4/ABCF2/IL1R1/TUBB4B/BRK1/GNA12/MAPK14/CASP3/BAIAP2L1/IRAK1/BAK1	0.165844119541349
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1368	78/9376	1.05443094916779	TPI1/IMPA2/PTEN/INPP4B/PIK3C2G/IP6K2/PIK3C2A/INPP5A/SACM1L/PIK3CB/INPP4A/MTMR7	0.199510194813683
Cellular Processes	Cell motility	hsa04814	Motor proteins	29/1368	194/9376	1.02453728823778	DYNLL1/ACTG1/TUBA1C/TPM2/MYL4/MYO1B/TNNI2/MYL6B/MYO10/KIF5B/MYO7A/CENPE/TUBB4B/KIF2C/KIF11/DYNC1LI1/KIF15/KIF23/KIFC1/KIF20A/DNALI1/KIF14/MYL5/DCTN2/DCTN5/TUBD1/DCTN1/KIF20B/MYO19	0.142733343763047
NA	NA	hsa04981	Folate transport and metabolism	5/1368	31/9376	1.10545180154688	ABCG2/SLC19A1/SHMT2/SHMT1/MTHFD1	0.24305908148226
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1368	148/9376	1.01880828196618	MAP2K2/GRB2/CSNK1A1/FZD3/DVL3/PTEN/RPS6KB2/FRAT2/FGFR1/WNT7A/MYC/AKT2/FGF7/BAK1/FLT4/DLL1/RPS6KB1/LRP5/BRAF/PIK3CB/IGF1/NRAS	0.0953219342496808
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/1368	59/9376	1.04549509366637	MAP2K2/GRB2/PTEN/MYC/AKT2/BAK1/BRAF/PIK3CB/NRAS	0.144883582535491
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	49/1368	333/9376	1.00851728921904	HLA-G/CCNE1/HLA-C/PKM/CDC42/MAP2K2/CCNA2/GRB2/LAMA1/EIF4EBP1/LAMA4/PPP2R1A/CSNK1A1/HDAC1/ATP6V0B/FZD3/DVL3/PPP2R5C/MAGI1/PTEN/RPS6KB2/ATP6V0A4/ITGAV/LAMB1/HDAC2/CDKN1B/ATP6V1C2/ATP6V1A/WNT7A/TBPL1/CASP3/LAMC1/AKT2/COL9A3/ITGA6/CHD4/PPP2R5E/BAK1/PRKCZ/PPP2R1B/CREB1/UBE3A/LAMA5/RPS6KB1/PPP2R5A/PIK3CB/RFNG/NRAS/DLG1	0.0654084564793375
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/1368	107/9376	1.02486746461168	LDHA/PYGL/CALM3/PKM/SLC2A1/CALM1/PRMT1/PGAM1/PDHB/G6PC3/PDHA1/CPT1C/ACACA/AKT2/CREB1/PPP3CB	0.106923609466697
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	30/1368	203/9376	1.01287702013655	ACTG1/CAV1/CDC42/PPP1CC/PGF/GRB2/PPP1CB/LAMA1/RHOA/LAMA4/PPP1CA/VCL/PTEN/ITGAV/LAMB1/CRK/PARVA/LAMC1/AKT2/PPP1R12A/COL9A3/ITGA6/PAK4/MYL5/FLT4/LAMA5/RAC3/BRAF/PIK3CB/IGF1	0.0766609773352127
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1368	32/9376	1.07090643274854	ATG12/ATG5/ATG4B/ATG9A/ATG10	0.166058406387619
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	23/1368	156/9376	1.0104963262858	CLDN10/CYCS/CLDN6/CLDN3/YWHAB/MAP2K2/GRB2/CLDN7/CLDN4/EIF2S1/YWHAQ/PPP2R1A/EIF3E/LDLR/MYC/CASP3/AKT2/PSME3/BAK1/PPP2R1B/BRAF/PIK3CB/NRAS	0.0546387576370769
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1368	46/9376	1.04296974319858	UROS/ALAS2/HMBS/CP/MMAB/ALAS1/GUSB	0.120744541532398
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1368	60/9376	1.0280701754386	CDC42/MAP2K2/MAPK13/MAPK14/AKT2/RAC3/PPP3CB/PIK3CB/NRAS	0.0901514397399875
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1368	60/9376	1.0280701754386	MAP2K2/PPP2R1A/GNA12/GNAI1/GNAI3/PPP2R1B/BRAF/IGF1/NRAS	0.0901514397399875
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	31/1368	212/9376	1.00220677479863	ACTG1/CALM3/CDC42/CALM1/ID1/PGF/MAP2K2/ENAH/RHOA/MAPK13/MAGI1/RALA/EVL/FGFR1/GNAI1/CRK/MAPK14/GNAI3/AKT2/CTNND1/ADCY5/FGF7/MAP2K6/PRKCZ/RALB/FLT4/RAC3/BRAF/PIK3CB/IGF1/NRAS	0.0134322900304806
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1368	26/9376	1.05443094916779	PLA2G2A/ACAA1/PLA2G12A/PLA2G10	0.114866511260369
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1368	26/9376	1.05443094916779	SLC19A1/SLC5A6/SLC19A2/ABCD4	0.114866511260369
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	33/1368	227/9376	0.996367570909653	HLA-G/CALM3/HLA-C/CYCS/CALM1/MAP2K2/CALR/GRB2/GNB2/EIF4EBP1/RHOA/MAPK13/PDIA3/IL1R1/RPS6KB2/ITGAV/GNA12/GNAI1/CRK/MAPK14/GNAI3/MYC/CASP3/AKT2/ADCY5/BAK1/MAP2K6/CREB1/RAC3/RPS6KB1/PPP3CB/PIK3CB/NRAS	-0.0228975973717159
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1368	61/9376	1.01121656600518	MT1G/SLC39A4/FXYD2/ATP1A1/SLC31A1/ATP2B1/SLC26A6/TRPM7/ATP2B4	0.0363245346154148
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1368	76/9376	0.991997537703909	PPARG/HMGCS1/SLC27A2/ACAA1/SCD/SLC27A5/CPT1C/ACSL4/PPARD/PLTP/SLC27A6	-0.028950469627844
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/1368	76/9376	0.991997537703909	CALM3/CALM1/MAP2K2/GRB2/PTEN/AKT2/BAK1/BRAF/PIK3CB/IGF1/NRAS	-0.028950469627844
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1368	69/9376	0.993304517331977	CALM3/PPP1CC/CALM1/PPP1CB/PPP1CA/HDAC1/HDAC2/ADCY5/CREB1/PPP3CB	-0.0230710963674124
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	15/1368	104/9376	0.988529014844804	PISD/LYPLA1/PTDSS2/AGPAT5/PLA2G2A/CHKA/AGPAT4/PLA2G12A/ETNK1/GPD1L/CHPT1/LCLAT1/GPAM/PLA2G10/PEMT	-0.0486180270097177
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1368	55/9376	0.996916533758639	GM2A/CERS4/SGPP1/KDSR/SMPD2/SMPD4/CERS5/SPTLC1	-0.00947885638818318
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1368	27/9376	1.01537795105047	ACAT2/ACAT1/HMGCS1/HADH	0.033072302452978
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	15/1368	105/9376	0.979114452798663	TOMM20/PHB2/RPS27A/TOMM40/BNIP3/EIF2S1/SAMM50/PGAM5/MFN1/OPA1/RAB7A/HUWE1/ATG9A/CCZ1/NRAS	-0.0889495738832717
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/1368	77/9376	0.979114452798663	CDC42/RALBP1/RPS6KB2/RALA/AKT2/BAK1/RALB/RAC3/RPS6KB1/BRAF/PIK3CB	-0.0760570981756753
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1368	63/9376	0.979114452798663	PTGDS/CBR1/PTGES2/PTGES3/CYP2J2/PLA2G2A/PLA2G12A/PTGR1/PLA2G10	-0.0687445045298379
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1368	49/9376	0.979114452798663	GXYLT1/B4GALT3/C1GALT1C1/POGLUT1/XXYLT1/RFNG/GALNT2	-0.0605814361506246
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/1368	120/9376	0.970955165692008	CALM3/CDC42/CALM1/MAP2K2/GRB2/RHOA/MAPK13/SORT1/SH2B2/ARHGDIA/CRK/MAPK14/AKT2/IRAK1/BRAF/PIK3CB/NRAS	-0.132347123940939
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1368	35/9376	0.979114452798663	AKR1B1/TPI1/ENOSF1/HK1/PFKFB4	-0.0511622751564073
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/1368	99/9376	0.969224407820899	MAP2K2/GRB2/LYPLA1/SLC44A1/EIF4EBP1/CHKA/RPS6KB2/SLC44A2/CHPT1/AKT2/RAC3/RPS6KB1/PIK3CB/NRAS	-0.127229227995808
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1368	71/9376	0.965324108393048	CGA/ELF5/MAP2K2/GRB2/MAPK13/MAPK14/AKT2/PRLR/PIK3CB/NRAS	-0.121217487207317
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1368	28/9376	0.979114452798663	ST3GAL4/FUT4/B4GALT3/B3GNT5	-0.0457437934198149
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1368	28/9376	0.979114452798663	CA2/ATP6V0A4/ATP6V1C2/ATP6V1A	-0.0457437934198149
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	24/1368	170/9376	0.967595459236326	CLDN10/ACTG1/TUBA1C/CDC42/CLDN6/CLDN3/RAB13/CLDN7/CLDN4/JAM3/MYL6B/RHOA/ACTR2/PPP2R1A/HSPA4/ARPC4/RAP2C/EPB41L4B/MAGI1/ARHGAP17/CGNL1/PRKCZ/PPP2R1B/DLG1	-0.176222558013382
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1368	21/9376	0.979114452798663	PANK3/AASDHPPT/ALDH3A2	-0.0396004630673892
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/1368	93/9376	0.958058228007294	CGA/CALM3/CDC42/MMP2/CALM1/MAP2K2/GRB2/MAPK13/MAP3K4/MAPK14/ADCY5/MAP2K6/NRAS	-0.168000559731282
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	22/1368	157/9376	0.960405259433084	ACTG1/PPP1CC/ID1/BMP4/YWHAB/BIRC5/ID2/PPP1CB/TEAD4/YWHAQ/PPP2R1A/PPP1CA/FZD3/DVL3/DLG5/WNT7A/MYC/YAP1/CSNK1E/PRKCZ/PPP2R1B/DLG1	-0.20678168745626
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1368	36/9376	0.951916829109812	AKR1B1/DCXR/CRYL1/GUSB/UGDH	-0.119464141591456
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/1368	137/9376	0.950527169505272	ACTG1/TUBA1C/CYCS/BIRC5/MAP2K2/ENDOG/EIF2S1/CAPN1/LMNB2/AIFM1/HTRA2/DFFA/CASP3/AKT2/ERN1/BAK1/PIK3CB/NRAS/CASP6	-0.241091119219915
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1368	73/9376	0.938876872546663	MAP2K2/PTEN/FGFR1/AKT2/FGF7/BAK1/BRAF/PIK3CB/IGF1/NRAS	-0.216681653822649
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1368	37/9376	0.926189347241979	HBA2/HBA1/LAMA4/THOP1/HBB	-0.185924394200642
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1368	30/9376	0.913840155945419	CYP2J2/PLA2G2A/PLA2G12A/PLA2G10	-0.195352645957064
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	19/1368	139/9376	0.936850519584333	KRT19/HSP90AB1/CALM3/FKBP4/MMP2/HSPA8/CALM1/HSP90B1/HSP90AA1/MAP2K2/GRB2/KRT10/GNAI1/GNAI3/AKT2/ADCY5/CREB1/PIK3CB/NRAS	-0.310011899821778
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/1368	67/9376	0.920659858601728	CALM3/PPP1CC/CALM1/MAP2K2/PPP1CB/PPP1CA/PPP3CB/BRAF/NRAS	-0.269367695607536
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1368	45/9376	0.913840155945419	ABCG2/ABCA7/ABCD3/DEFB1/ABCB7/ABCD4	-0.239449382312602
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1368	23/9376	0.89397406559878	B3GALNT2/FUT4/B4GALT3	-0.210410405851452
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	28/1368	205/9376	0.936128940236771	HLA-G/CCNE1/HLA-C/CYCS/CALR/CCNA2/MAPK13/PSMC4/HDAC1/PDIA3/PSMD8/PSMC5/PSMD3/PSMD12/HDAC2/CDKN1B/PSMD11/PSMD6/MAPK14/MYC/CASP3/AKT2/SKP2/IRAK1/BAK1/MAP2K6/SAP30/PIK3CB	-0.3821548367326
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1368	31/9376	0.884361441237502	GUSB/UGDH/ALDH3A2/ALDH9A1	-0.266538849639758
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1368	31/9376	0.884361441237502	CNDP2/ALDH3A2/ALDH3B2/ALDH9A1	-0.266538849639758
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	25/1368	184/9376	0.931222984998729	CDC42/ENAH/SEMA6A/RHOA/CFL2/FZD3/EPHB4/FES/GNAI1/RGS3/GNAI3/PLXNA1/SRGAP1/SEMA4B/ROBO1/PAK4/PRKCZ/MYL5/RAC3/PPP3CB/PIK3CB/NRAS/EPHB3/RHOD/SEMA4G	-0.389416080586325
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/1368	134/9376	0.920659858601728	CALM3/PPP1CC/CALM1/MAP2K2/PPP1CB/MYL6B/RHOA/PLA2G2A/PPP1CA/PLA2G12A/GNA12/PPP1R14A/PPP1R12A/ADCY5/RAMP1/PLA2G10/RAMP2/BRAF	-0.382321782100694
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1368	76/9376	0.90181594336719	ACTG1/CALM3/CALM1/GAST/ATP1A1/CA2/GNAI1/GNAI3/ADCY5/SLC9A1	-0.355199992741624
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	22/1368	163/9376	0.925052918595056	CCNE1/CYCS/YWHAB/BIRC5/MAP2K2/CCNA2/GRB2/YWHAQ/MAPK13/DDX3X/VDAC3/DDB1/MAPK14/MYC/CASP3/AKT2/IRAK1/MAP2K6/CREB1/BRAF/PIK3CB/NRAS	-0.398946488193025
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/1368	98/9376	0.909177706170187	CALM3/CALM1/IMPA2/PTEN/INPP4B/PIK3C2G/IP6K2/PIK3C2A/INPP5A/SACM1L/PIK3CB/INPP4A/MTMR7	-0.373546760775665
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/1368	69/9376	0.89397406559878	MAP2K2/GRB2/MAPK13/MAPK14/AKT2/MAP2K6/RAC3/PIK3CB/NRAS	-0.365341032349781
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/1368	99/9376	0.899994092976549	CALM3/PPP1CC/CALM1/PPP1CB/CYP2J2/MAPK13/PPP1CA/IL1R1/MAPK14/ADCY5/MAP2K6/PIK3CB/IGF1	-0.413433940493097
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	20/1368	150/9376	0.913840155945419	CCNE1/MAP2K2/GRB2/CSNK1A1/FZD3/DVL3/RPS6KB2/FRAT2/JUP/CDKN1B/WNT7A/MYC/AKT2/FGF7/BAK1/RPS6KB1/LRP5/BRAF/PIK3CB/NRAS	-0.439653427556538
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1368	32/9376	0.85672514619883	AKR1B1/G6PC3/HK1/PGM1	-0.335540697443025
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	29/1368	216/9376	0.920186268139485	HSP90AB1/CALM3/HSPA5/HSPD1/CDC42/CYCS/HSPA8/CALM1/HSP90B1/HSP90AA1/PYCARD/PPARG/EIF2S1/RHOA/CYP2J2/MAPK13/HSPA4/LDLR/XBP1/MAPK14/CASP3/AKT2/ERN1/IRAK1/MAP2K6/PPP3CB/PIK3CB/NRAS/CASP6	-0.490482380634392
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1368	48/9376	0.85672514619883	FXYD2/ATP1A1/G6PC3/HK1/AKT2/PIK3CB	-0.411304043084729
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/1368	93/9376	0.884361441237502	ACTG1/CDC42/ACP1/RHOA/IQGAP1/VCL/FGFR1/CTNND1/HEG1/MYL5/RAC3/YES1	-0.463197945046219
NA	NA	hsa04382	Cornified envelope formation	29/1368	217/9376	0.915945778424556	KRT19/CLDN10/CLDN6/S100A13/CLDN3/CLDN7/CLDN4/KRT10/ELOVL1/CAPN1/DSP/PPP2R1A/S100A1/PKP3/PPP2R5C/DSG2/JUP/PADI1/KDSR/FURIN/ABHD5/ITGA6/S100A16/PPP2R5E/SPTLC1/PPP2R1B/KRT80/LAMA5/PPP2R5A	-0.517764204848815
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/1368	71/9376	0.868791697553744	CDC42/JAM3/MAPK13/ATP6V0B/ATP6V0A4/ATP6V1C2/MAPK14/ATP6V1A/CASP3	-0.458668544231013
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/1368	33/9376	0.830763778132199	VTI1B/STX2/STX8/GOSR2	-0.402507309460291
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1368	17/9376	0.806329549363605	DAG1/TFRC	-0.330323715442954
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/1368	41/9376	0.835829410925688	MMP2/MAP2K2/MYC/BRAF/NRAS	-0.435408375031711
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/1368	79/9376	0.867569768302613	ATP6V0B/ATP6V0A4/ATP6V1C2/ATP6V1A/NAPA/NSF/AP2A1/STX2/SLC1A2/SLC6A11	-0.488535270512551
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/1368	94/9376	0.874953340798805	HSP90AB1/HSP90B1/HSP90AA1/SRSF1/ANAPC5/MAPK13/TRAF4/MAPK14/ELAVL1/CASP3/IL17D/USP25	-0.503595560453127
NA	NA	hsa04518	Integrin signaling	20/1368	154/9376	0.890104047998785	ACTG1/CDC42/PGF/ITGAE/LAMA1/LAMA4/VCL/ITGAV/LAMB1/FRAS1/PARVA/LAMC1/AKT2/COL9A3/ITGA6/FLT4/LAMA5/RAC3/PIK3CB/IGF1	-0.56832420315684
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	22/1368	169/9376	0.892210803141977	RPS27A/BNIP3/MAP2K2/EIF2S1/ATG12/PTEN/RPS6KB2/ATG5/WDR45B/AKT2/ERN1/AKT1S1/RAB7A/ATG4B/ATG9A/GORASP2/VPS33A/ATG10/RPS6KB1/PIK3CB/NRAS/BIRC6	-0.584421482197838
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1368	50/9376	0.822456140350877	HBA2/HBA1/GYPC/GYPB/GYPA/HBB	-0.520247028224018
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/1368	89/9376	0.847099020960641	LAMA1/HMMR/LAMA4/DAG1/ITGAV/LAMB1/FRAS1/LAMC1/COL9A3/ITGA6/LAMA5	-0.599010177650701
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1368	43/9376	0.796953624371005	ACAT2/ACAT1/PLA2G2A/PLA2G12A/PLA2G10	-0.551550764993016
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1368	51/9376	0.806329549363605	PLA2G2A/PAFAH1B1/PLA2G12A/CHPT1/PLA2G10/AGPS	-0.573179547859837
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1368	59/9376	0.813162850629398	CGA/GNAI1/GNAI3/AKT2/ADCY5/ABHD5/PIK3CB	-0.595001204966013
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/1368	90/9376	0.837686809616634	MAP2K2/MAPK13/PTEN/RPS6KB2/MAPK14/AKT2/MAP2K6/RPS6KB1/PPP3CB/PIK3CB/NRAS	-0.639480614941062
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	33/1368	253/9376	0.89397406559878	ACTG1/RPS27A/CDC42/CYCS/BNIP3/PYCARD/VDAC1/UBE2V2/U2AF1/RHOA/PPID/UBE2D3/MAPK13/CAPN1/ACTR2/HK1/UBE2D2/ARPC4/FNBP1/ATG12/VCL/IL1R1/RPS6KB2/CRK/ATG5/MAPK14/AKT2/CUL1/AKT1S1/MYL5/RPS6KB1/PIK3CB/GLMN	-0.706594392181891
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/1368	83/9376	0.825759177059114	PYCARD/POLR2H/G3BP1/POLR1D/POLR2E/POLR3H/CASP3/POLR3G/GSDMD/DNASE2	-0.658988211804333
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	30/1368	232/9376	0.88626739261948	ACTG1/CDC42/PPP1CC/MAP2K2/ENAH/PPP1CB/ITGAE/RHOA/ACTR2/PPP1CA/CFL2/ARPC4/IQGAP1/VCL/BRK1/ITGAV/GNA12/FGFR1/CRK/AKT2/PPP1R12A/ITGA6/FGF7/PAK4/MYL5/SLC9A1/RAC3/BRAF/PIK3CB/NRAS	-0.724982517738585
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1368	28/9376	0.734335839598998	AKR1B1/CBR1/PCBD2	-0.581861052300048
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1368	53/9376	0.775902019198941	FXYD2/ATP1A1/ATP2B1/AP2A1/PTH1R/ATP2B4	-0.676183689491783
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1368	20/9376	0.685380116959064	UGDH/GNE	-0.582133659338324
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1368	29/9376	0.709013914095584	TEAD4/YAP1/CSNK1E	-0.648637054803714
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/1368	101/9376	0.814313010248393	CALM3/CALM1/MAP2K2/FZD3/DVL3/GNAI1/GNAI3/WNT7A/ADCY5/EDNRB/CREB1/NRAS	-0.775446532212219
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/1368	78/9376	0.790823211875843	ACTG1/CAV1/CDC42/RHOA/ACTR2/ARPC4/VCL/CRK/PIK3CB	-0.766712732135229
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/1368	86/9376	0.796953624371005	ACTG1/DSC2/LAMA1/DSP/DAG1/DSG2/ITGAV/JUP/ATP2A2/ITGA6	-0.781813679432268
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/1368	38/9376	0.721452754693752	FXYD2/ATP1A1/PIK3CB/IGF1	-0.711099520885349
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/1368	155/9376	0.840143369175627	HLA-G/ACTG1/HLA-C/TUBA1C/CALR/CANX/SEC61B/ATP6V0B/SEC61A1/SEC61G/C1R/TUBB4B/ATP6V0A4/ITGAV/ATP6V1C2/DYNC1LI1/ATP6V1A/TFRC/RAB7A	-0.829419321577103
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/1368	102/9376	0.806329549363605	FXYD2/RHOA/ATP1A1/PLA2G2A/PLA2G12A/CA2/ATP2A2/ADCY5/ATP2B1/PLA2G10/SLC9A1/ATP2B4	-0.812824073800413
Organismal Systems	Immune system	hsa04611	Platelet activation	15/1368	126/9376	0.815928710665553	ACTG1/PPP1CC/PPP1CB/RHOA/MAPK13/PPP1CA/GNAI1/MAPK14/GNAI3/AKT2/PPP1R12A/ADCY5/PRKCZ/STIM1/PIK3CB	-0.859739964653255
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1368	217/9376	0.852777104050449	HSP90AB1/KPNA2/MGST3/MGST1/BIRC5/HSP90B1/HSP90AA1/MAP2K2/GSTA4/GRB2/KPNB1/PTGES3/EIF4EBP1/RPS6KB2/GNAI1/GNAI3/MYC/AKT2/ADCY5/KPNA4/FGF7/CREB1/CDC25A/DLL1/RPS6KB1/PIK3CB/NRAS	-0.906875874026635
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1368	56/9376	0.734335839598998	CSNK1A1/LRP2/CUL3/CSNK1G2/CUL1/CSNK1E	-0.824110944100712
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/1368	73/9376	0.751101498037331	MAP2K2/GRB2/KIF5B/AKT2/BAK1/BRAF/PIK3CB/NRAS	-0.882345869497995
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/1368	65/9376	0.738101664417454	AKR1B1/AGPAT5/AGPAT4/LCLAT1/GPAM/ALDH3A2/ALDH9A1	-0.875705158604397
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/1368	105/9376	0.783291562238931	CALM3/CALM1/PYCARD/RHOA/MAPK13/CBLB/MAPK14/IL17D/AKT2/PPP3CB/PIK3CB/NRAS	-0.922940778612829
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1368	90/9376	0.761533463287849	SLC2A1/ABCG2/HMGCR/FXYD2/ATP1A1/SLC27A5/CA2/LDLR/ADCY5/SLC9A1	-0.939509150053522
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	46/1368	362/9376	0.870925010500469	RPS6/CCNE1/HSP90AB1/EIF4B/YWHAB/PGF/HSP90B1/HSP90AA1/MAP2K2/GRB2/THEM4/LAMA1/GNB2/YWHAQ/EIF4EBP1/G6PC3/LAMA4/PPP2R1A/EIF4E/PPP2R5C/MAGI1/PTEN/RPS6KB2/ITGAV/LAMB1/CDKN1B/FGFR1/MYC/LAMC1/AKT2/COL9A3/SGK2/PRLR/ITGA6/PPP2R5E/FGF7/PPP2R1B/CREB1/FLT4/LAMA5/RPS6KB1/PPP2R5A/PIK3CB/IGF1/PKN3/NRAS	-1.03515232389357
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/1368	122/9376	0.786501773559582	MAP2K2/GRB2/MAPK13/GNAI1/CRK/MAPK14/GNAI3/AKT2/ADCY5/MAP2K6/CREB1/PIK3CB/IGF1/NRAS	-0.981016007739713
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/1368	130/9376	0.790823211875843	MMP2/MAP2K2/GRB2/GNB2/MAPK13/GNAI1/MAPK14/GNAI3/AKT2/ADCY5/EDNRB/PRKCZ/CREB1/PIK3CB/NRAS	-0.992601384100954
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/1368	115/9376	0.774777523518942	NACA/GCM1/RHOA/PDE4D/GNA12/FGFR1/GNAI1/GNAI3/ADCY5/CREB1/PTH1R/LRP5/BRAF	-1.0043807080372
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	24/1368	201/9376	0.818364318757092	ETV5/CCNA2/ID2/PPARG/EWSR1/HDAC1/FUS/DDX5/HDAC2/JUP/CDKN1B/SS18/MYC/ETV4/PRCC/LMO2/DUSP6/BAK1/ETV1/MYCN/CCNT1/IGF1/MLF1/CCNT2	-1.07587747246438
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1368	14/9376	0.489557226399332	B4GALT3	-0.789938741845179
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1368	34/9376	0.604747162022704	CUL1/CSNK1E/CREB1	-0.954247824729255
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1368	69/9376	0.695313162132384	CALM3/CALM1/GNAI1/GNAI3/ADCY5/CREB1/PPP3CB	-1.04988090431452
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	30/1368	250/9376	0.822456140350877	LAPTM4B/GM2A/CD164/ATP6V0B/SORT1/VPS26A/ATP6V0A4/ATP6V1C2/LAMTOR1/SLC38A9/AP1S1/ATP6V1A/VPS29/CLN5/GUSB/AP3D1/CLN6/AKT1S1/RAB7A/SLC36A4/AP2A1/PPT2/BLOC1S4/SNAPIN/OSBPL1A/VPS33A/AP3M1/OSBP/DNASE2/SLC29A2	-1.17598581605414
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/1368	70/9376	0.685380116959064	LEP/SLC2A1/G6PC3/CPT1C/ACSL4/AKT2/ADIPOR2	-1.09199416019374
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/1368	103/9376	0.731959348208709	SERPINB9/LAMA1/LAMA4/VCL/IL1R1/LAMB1/CASP3/LAMC1/RAB7A/LAMA5/PIK3CB	-1.13051362917065
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/1368	62/9376	0.663271080928127	HDAC1/DVL3/HDAC2/CTBP2/DLL1/RFNG	-1.09944826641906
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1368	15/9376	0.45692007797271	SLC33A1	-0.869991297769953
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1368	144/9376	0.761533463287849	MAPK13/TRA2A/TRA2B/SCD/ADH5/FASN/CPT1C/ACACA/MAPK14/CASP3/AKT2/IRAK1/MAP2K6/ALDH3A2/ADIPOR2/ALDH9A1	-1.19186604460697
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/1368	168/9376	0.775132275132275	PYGL/HSP90AB1/SLC25A6/HSP90AA1/PYCARD/VDAC1/CHMP4A/PPIA/VDAC2/PPID/CAPN1/AIFM1/VDAC3/PGAM5/CHMP6/CHMP7/GLUD1/DNM1L/TRPM7	-1.21553023546509
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/1368	72/9376	0.666341780376868	MAPK13/DDX3X/PIN1/ATG12/SIKE1/ATG5/MAPK14	-1.17462673166921
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/1368	138/9376	0.744978387998983	ACTG1/CDC42/PYCARD/MAP2K2/RHOA/MAPK13/ACTR2/ARPC4/CRK/MAPK14/AKT2/IRAK1/MAP2K6/RAC3/PIK3CB	-1.24736687138772
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/1368	154/9376	0.756588440798967	ACTG1/CALM3/EEF2/PPP1CC/CALM1/MAP2K2/PPP1CB/MYL6B/RHOA/PPP1CA/GNAI1/GNAI3/PPP1R12A/ADCY5/EEF2K/PPP3CB/NRAS	-1.25879687015734
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	20/1368	178/9376	0.770090019055128	CACYBP/RUVBL1/RHOA/LGR4/CSNK1A1/FZD3/DVL3/FRAT2/DKK1/WNT7A/PPARD/MYC/CTBP2/CUL1/CSNK1E/RNF43/CHD8/RAC3/PPP3CB/LRP5	-1.27993459790836
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/1368	98/9376	0.69936746628476	CDC42/MYO10/ACTR2/CFL2/ARPC4/RPS6KB2/CRK/AKT2/RPS6KB1/PIK3CB	-1.23648395583955
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/1368	98/9376	0.69936746628476	CALM3/CYP11A1/CALM1/ATP1A1/HSD3B1/LDLR/ADCY5/ATP2B1/CREB1/ATP2B4	-1.23648395583955
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/1368	233/9376	0.794217302913937	ACTG1/ENO1/TPM2/MYL4/DSC2/TNNI2/LBR/LAMA1/ATP1A1/LMNB2/DSP/NID1/DAG1/DSG2/VCL/INF2/ITGAV/JUP/TMOD3/ANK3/SPTBN1/COL9A3/ITGA6/SYNE2/MYL5/VCAN/COL27A1	-1.3146468655289
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1368	47/9376	0.583302227199204	PKM/HK1/PRKCZ/PIK3CB	-1.18363886346363
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/1368	65/9376	0.632658569500675	CGA/MAP2K2/AKT2/KISS1R/PIK3CB/NRAS	-1.22827350140218
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	15/1368	140/9376	0.734335839598998	RPS6/CALM3/CALM1/MYL4/MAP2K2/GNB2/TFAM/RPS6KB2/GNAI1/GNAI3/AKT2/ADCY5/SLC9A1/RPS6KB1/NRAS	-1.3089458482809
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1368	38/9376	0.541089566020314	NT5C/NNMT/NADK	-1.1715462824752
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1368	17/9376	0.403164774681803	SLC27A5	-1.01796029537038
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1368	17/9376	0.403164774681803	GGT7	-1.01796029537038
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1368	66/9376	0.623072833599149	CYP11A1/COMT/HSD17B12/HSD3B1/SRD5A3/HSD17B7	-1.27005117777826
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/1368	101/9376	0.678594175206994	CDC42/MMP2/MAPK13/CDKN1B/MAPK14/CASP3/AKT2/PRKCZ/PIK3CB/NRAS	-1.34222129725913
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1368	29/9376	0.472675942730389	CALM3/CALM1	-1.17545800298802
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/1368	49/9376	0.559493973027808	GNAI1/GNAI3/ADCY5/CREB1	-1.27774903332546
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/1368	103/9376	0.665417589280645	CALR/MAPK13/PPP2R1A/GNAI1/MAPK14/GNAI3/AKT2/IRAK1/PPP2R1B/PIK3CB	-1.41116645132443
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1368	19/9376	0.360726377346876	GUSB	-1.15282112348067
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1368	41/9376	0.501497646555413	SSBP1/POLD2/XRCC3	-1.32211318048291
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/1368	155/9376	0.707489152990002	CCNE1/CYP11A1/MAP2K2/FZD3/DVL3/HSD3B1/WDR5/LDLR/CDKN1B/FH/GNAI1/GNAI3/WNT7A/ADCY5/CREB1/BRAF	-1.51769837153346
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1368	79/9376	0.607298837811829	MGST3/MGST1/CBR1/GSTA4/ADH5/CYP2S1/ALDH3B2	-1.44867501960262
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/1368	89/9376	0.616072015244103	TUBA1C/MAP2K2/GRB2/TUBB4B/GNAI1/GNAI3/ADCY5/NRAS	-1.50408958659778
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1368	63/9376	0.543952473777035	BMP4/FZD3/DVL3/WNT7A/BAK1	-1.50107444780041
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/1368	91/9376	0.602531970953024	MAP2K2/GRB2/AKT2/RAC3/PPP3CB/PIK3CB/NRAS/IFITM1	-1.57470279389962
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1368	44/9376	0.467304625199362	HLA-G/HLA-C/HSPD1	-1.46380947456441
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/1368	226/9376	0.727837292345909	CGA/CALM3/PPP1CC/CALM1/MAP2K2/PPP1CB/FXYD2/RHOA/ATP1A1/PPP1CA/PDE4D/GNAI1/GNAI3/ATP2A2/AKT2/PPP1R12A/ADCY5/ATP2B1/CREB1/SLC9A1/RAC3/BRAF/PIK3CB/ATP2B4	-1.71174451191524
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/1368	65/9376	0.527215474583896	CYP11A1/HSD3B1/LDLR/ADCY5/CREB1	-1.58084184419997
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/1368	93/9376	0.589574294158335	CALM3/CALM1/FXYD2/ATP1A1/ADCY5/ATP2B1/SLC9A1/ATP2B4	-1.64398748630597
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/1368	187/9376	0.696375519904932	HSP90AB1/TXN2/SUGT1/HSP90AA1/PYCARD/VDAC1/VDAC2/TRIP6/RHOA/MAPK13/VDAC3/ATG12/ATG5/MAPK14/MFN1/DHX33/DNM1L/TRPM7/GSDMD	-1.7333653721875
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	33/1368	300/9376	0.753918128654971	CDC42/HSPA8/PGF/MAP2K2/GRB2/MAPK13/ECSIT/IL1R1/MAP3K8/DUSP5/GNA12/FGFR1/MKNK1/CRK/MAP3K4/MAP3K13/MAPK14/MAP4K4/NF1/MYC/CASP3/AKT2/DUSP6/FGF7/IRAK1/MAP2K6/FLT4/RAC3/PPP3CB/BRAF/CDC25B/IGF1/NRAS	-1.79043953558833
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1368	103/9376	0.598875830352581	SLC1A5/SLC3A2/FXYD2/ATP1A1/SLC7A8/COL9A3/SLC36A4/COL18A1/COL27A1	-1.69181927347821
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/1368	181/9376	0.681593486478627	CALM3/HSPD1/CYCS/CALM1/HSPA9/RHOA/MAPK13/ATP6V0B/NFYB/ATP6V0A4/MAPK14/RFXANK/CASP3/AKT2/RAB7A/IRAK1/CREB1/PPP3CB	-1.78777153715164
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1368	36/9376	0.380766731643925	C1GALT1C1/GALNT2	-1.53850441806295
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/1368	173/9376	0.673494912618734	ACTG1/KPNA2/CYCS/SLC25A6/PYCARD/VDAC1/MAP2K2/XPO1/EIF2S1/DNAJC3/PABPN1/RAE1/CASP3/AKT2/NUP98/BAK1/PIK3CB	-1.79149230777857
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/1368	105/9376	0.587468671679198	ACTG1/TPM2/LAMA1/DAG1/ITGAV/ATP2A2/ADCY5/ITGA6/IGF1	-1.75693198334239
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1368	38/9376	0.360726377346876	ADA/RFXANK	-1.63199304406505
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/1368	89/9376	0.53906301333859	GNB2/SLC38A1/GNAI1/GNAI3/ADCY5/NSF/SLC6A11	-1.80578272291348
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/1368	99/9376	0.5538425187548	ACTG1/TPM2/LAMA1/DAG1/ITGAV/ATP2A2/ITGA6/IGF1	-1.84445750297954
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1368	39/9376	0.35147698305593	HLA-G/HLA-C	-1.67733833655697
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/1368	136/9376	0.604747162022704	CCNE1/CYCS/HSPA8/EIF2S1/CBLB/RCHY1/CDKN1B/CASP3/AKT2/IRAK1/BAK1/PIK3CB	-1.91900064253409
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/1368	196/9376	0.664399092970522	HLA-G/CALM3/HLA-C/RPS27A/CYCS/CALM1/MAP2K2/GNB2/MAPK13/MAPK14/MYC/CASP3/AKT2/BAK1/MAP2K6/CREB1/PPP3CB/PIK3CB/NRAS	-1.96244039872789
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	24/1368	238/9376	0.691139613740233	CALM3/CDC42/CALM1/PGF/MAP2K2/GRB2/GNB2/RHOA/PLA2G2A/RALBP1/PLA2G12A/RALA/FGFR1/NF1/AKT2/FGF7/PAK4/PLA2G10/RALB/FLT4/RAC3/PIK3CB/IGF1/NRAS	-1.994765124234
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/1368	119/9376	0.575949678116861	MAPK13/MAP3K8/PGAM5/MAPK14/CASP3/AKT2/MAP2K6/CREB1/DNM1L/PIK3CB	-1.92407678969181
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1368	73/9376	0.469438436273332	MGST3/MGST1/GSTA4/ADH5/ALDH3B2	-1.88084219301101
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1368	54/9376	0.380766731643925	CGA/HLA-G/HLA-C	-1.88609370716828
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1368	86/9376	0.478172174622603	SLC2A1/FXYD2/ATP1A1/TRPM4/ADCY5/CREB1	-2.0092559196126
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/1368	97/9376	0.494604208114789	CALM3/CALM1/GNB2/GNAI1/GNAI3/ADCY5/CREB1	-2.06791915430685
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/1368	88/9376	0.467304625199362	TFPI/CFD/CD55/PROCR/C1R/C1S	-2.07503684864278
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1368	45/9376	0.30461338531514	HLA-G/HLA-C	-1.93256959993172
NA	NA	hsa04519	Cadherin signaling	43/1368	404/9376	0.729488738347519	KRT19/ACTG1/CDC42/PPP1CC/YWHAB/DSC2/MAP2K2/ENAH/MYO1B/PPP1CB/KRT10/TEAD4/MYO7A/YWHAQ/RHOA/MAPK13/ACTR2/DSP/CSNK1A1/PPP1CA/ARPC4/FZD3/DVL3/PKP3/DSG2/VCL/DSC3/BRK1/EVL/JUP/FGFR1/MAPK14/WNT7A/CTNND1/YAP1/CIB2/KRT80/CDH3/FLT4/RERE/RAC3/LRP5/NRAS	-2.29719601741602
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1368	68/9376	0.403164774681803	RDH11/PNPLA4/ADH5/CYP2S1	-2.04149053651513
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/1368	109/9376	0.503031278502066	MAP2K2/MAPK13/MAP3K8/MAPK14/AKT2/IRAK1/MAP2K6/PIK3CB	-2.15694652313139
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1368	191/9376	0.610024187869324	CALM3/PPP1CC/CALM1/GRB2/PPP1CB/GNB2/PPP1CA/HDAC1/HDAC2/GNAI1/GNAI3/ADCY5/CREB1/BRAF/HDAC3/SLC29A2/NRAS	-2.25051249818949
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1368	70/9376	0.391645781119465	MGST3/MGST1/CBR1/GSTA4	-2.11149800173416
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/1368	193/9376	0.603702693694513	CCR7/CDC42/CXCL14/GRB2/GNB2/RHOA/GNAI1/CRK/GNAI3/AKT2/ADCY5/PRKCZ/CCL21/RAC3/BRAF/PIK3CB/NRAS	-2.2991861643704
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/1368	149/9376	0.551983986812669	MAP2K2/GRB2/RHOA/AGPAT5/AGPAT4/RALA/GNA12/AKT2/ADCY5/RALB/PIK3CB/NRAS	-2.27836376797908
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/1368	142/9376	0.530928259616177	GRB2/PPARG/MAPK13/IL1R1/MAPK14/ATP2A2/AKT2/MAP2K6/CREB1/PPP3CB/PIK3CB	-2.32785090510059
NA	NA	hsa04517	IgSF CAM signaling	29/1368	299/9376	0.664749946214477	DYNLL1/ACTG1/TUBA1C/CDC42/MAP2K2/GRB2/JAM3/MYL6B/CLMP/RHOA/MAPK13/ACTR2/ARPC4/IQGAP1/MAGI1/VCL/ERC1/TUBB4B/FGFR1/MAPK14/ANK3/SPTBN1/AKT2/PLXNA1/SRGAP1/ROBO1/PAK4/MTSS1/PIK3CB	-2.43500544837755
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/1368	133/9376	0.515323396209823	HLA-G/HLA-C/MAP2K2/GRB2/CASP3/RAC3/PPP3CB/BRAF/PIK3CB/NRAS	-2.32668748955225
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/1368	115/9376	0.476786168319349	GNB2/GNAI1/GNAI3/AKT2/ADCY5/CREB1/PIK3CB/NRAS	-2.3332745777816
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/1368	115/9376	0.476786168319349	GNB2/CYP2J2/GNAI1/GNAI3/CASP3/ADCY5/BRAF/NRAS	-2.3332745777816
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1368	99/9376	0.4153818890661	KRT19/CFD/KRT10/C1R/DEFB1/C1S	-2.41686692797412
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/1368	195/9376	0.562363172889489	ACTG1/SLC25A6/VDAC1/MAP2K2/PPIF/VDAC2/MAPK13/VDAC3/HDAC1/HDAC2/CLCN3/MAPK14/AKT2/PIK3CB/GSDMD/HDAC3	-2.55242404579466
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/1368	100/9376	0.411228070175439	GYPA/CD55/IL1R1/ANPEP/TFRC/ITGA6	-2.44643330891968
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/1368	54/9376	0.253844487762616	FANCI/REV3L	-2.27268024525874
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/1368	160/9376	0.514035087719298	HLA-G/CLDN10/HLA-C/CLDN6/CLDN3/CLDN7/CLDN4/JAM3/ITGAV/ITGA6/CDH3/VCAN	-2.56247906716732
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/1368	91/9376	0.37658248184564	GNB2/PDE4D/GNAI1/GNAI3/ADCY5	-2.46987741368153
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/1368	116/9376	0.413591449889091	GNB2/SLC38A1/GNAI1/GNAI3/ADCY5/SLC1A2/PPP3CB	-2.6265788920481
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/1368	109/9376	0.377273458876549	HSP90AB1/HSP90AA1/MAPK13/IL1R1/MAPK14/PPP3CB	-2.70276134016907
NA	NA	hsa04081	Hormone signaling	17/1368	219/9376	0.532030227776443	CGA/LEP/GAST/GNB2/RHOA/ITGAV/GNA12/GNAI1/GNAI3/ADCY5/PRLR/RAMP1/PTH1R/RAMP2/PIK3CB/IGF1/ADIPOR2	-2.89620905075115
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/1368	78/9376	0.263607737291948	MAPK13/MAPK14/IRAK1	-2.69915858603305
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/1368	93/9376	0.294787147079167	MAPK13/MAPK14/DLL1/PPP3CB	-2.82477702756571
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/1368	95/9376	0.288581101877501	ATP6V0B/ATP6V0A4/ATP6V1C2/ATP6V1A	-2.8804243164258
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/1368	105/9376	0.261097187412977	IL1R1/ERC1/IRAK1/CCL21	-3.14691732455831
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/1368	323/9376	0.530479966686582	CCNE1/MAP2K2/GRB2/IGF2BP1/RHOA/HDAC1/DNMT3B/FZD3/TRIM71/HNRNPK/PTEN/CCNG1/HDAC2/CDKN1B/CRK/CDC25C/MYC/CASP3/KIF23/BAK1/PAK4/CDC25A/PIK3CB/CDC25B/NRAS	-3.54916167284903
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/1368	100/9376	0.205614035087719	CCR7/CXCL14/CCL21	-3.30078963730283
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	16/1368	254/9376	0.431735506745867	CALM3/CALM1/SLC25A6/VDAC1/PPIF/VDAC2/VDAC3/FGFR1/ATP2A2/EDNRB/ATP2B1/FGF7/FLT4/STIM1/PPP3CB/ATP2B4	-3.79480094430505
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/1368	168/9376	0.285575048732943	LEP/GRB2/PTPN2/MYC/AKT2/PRLR/PIK3CB	-3.86184869236617
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1368	143/9376	0.191714718030507	SSB/SNRPD1/C1R/C1S	-4.02557503789922
NA	NA	hsa04082	Neuroactive ligand signaling	6/1368	199/9376	0.206647271444944	GNB2/GNAI1/GNAI3/ADCY5/SLC1A2/SLC6A11	-4.67529637494165
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/1368	298/9376	0.252992660622473	LEP/CCR7/BMP4/CXCL14/IL1R1/IL36RN/IL17D/PRLR/GDF11/ACVR2B/CCL21	-5.41632313571241
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/1368	370/9376	0.203761656393235	CGA/LEP/TMEM97/GZMA/EDNRB/PRLR/KISS1R/S1PR1/PTH1R/S1PR3/VGF	-6.45869286916541
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1368	449/9376	0.0305291811563058	CALM3/CALM1	-8.70105270017477