ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 88/2613 175/18639 0.502857142857143 3.586970641299 2.22070352301904e-30 2.800307142527e-27 GO:0043021 ribonucleoprotein complex binding 82/2613 177/18639 0.463276836158192 3.30463717916286 2.65483189823499e-25 1.67387151183716e-22 GO:0043022 ribosome binding 53/2613 112/18639 0.473214285714286 3.37552279809742 2.39513924172719e-17 1.00675686127266e-14 GO:0140104 molecular carrier activity 84/2613 249/18639 0.337349397590361 2.40637406111242 1.93174042161872e-15 6.08981167915302e-13 GO:0140098 catalytic activity, acting on RNA 112/2613 387/18639 0.289405684754522 2.06438291547629 1.11123469194544e-14 2.8025338930864e-12 GO:0019843 rRNA binding 34/2613 65/18639 0.523076923076923 3.73120197827431 3.12237955926723e-13 6.5622010403933e-11 GO:0180051 translation factor activity 39/2613 84/18639 0.464285714285714 3.31183368869936 8.31079803844908e-13 1.49713090378347e-10 GO:0016853 isomerase activity 63/2613 180/18639 0.35 2.49661308840413 9.75146484280284e-13 1.5370746458468e-10 GO:0030515 snoRNA binding 22/2613 32/18639 0.6875 4.90406142365098 2.42449126871279e-12 3.20548670626955e-10 GO:0051082 unfolded protein binding 48/2613 121/18639 0.396694214876033 2.82969133986773 2.78502413860618e-12 3.20548670626955e-10 GO:0008135 translation factor activity, RNA binding 38/2613 83/18639 0.457831325301205 3.26579336865257 2.79622155186083e-12 3.20548670626955e-10 GO:0003743 translation initiation factor activity 27/2613 51/18639 0.529411764705882 3.77638954548524 5.96517720694232e-11 6.26840704829522e-09 GO:0016887 ATP hydrolysis activity 108/2613 417/18639 0.258992805755396 1.84744236757551 6.86311348884729e-11 6.65722008418187e-09 GO:0045296 cadherin binding 91/2613 334/18639 0.272455089820359 1.94347126642238 1.27682553140204e-10 1.15005499649855e-08 GO:0140597 protein carrier chaperone 57/2613 188/18639 0.303191489361702 2.16271954466619 5.88311736770106e-09 4.94574066711402e-07 GO:0000049 tRNA binding 32/2613 80/18639 0.4 2.8532721010333 9.15456778943348e-09 7.21494373904726e-07 GO:0044183 protein folding chaperone 30/2613 75/18639 0.4 2.8532721010333 2.64328917892853e-08 1.96069862036993e-06 GO:0003727 single-stranded RNA binding 33/2613 89/18639 0.370786516853933 2.64488705994659 4.88294012536677e-08 3.42077083227083e-06 GO:0140662 ATP-dependent protein folding chaperone 20/2613 40/18639 0.5 3.56659012629162 6.52604333541044e-08 4.3312319189224e-06 GO:0140101 catalytic activity, acting on a tRNA 44/2613 139/18639 0.316546762589928 2.25798511592563 7.76191561808334e-08 4.89388779720155e-06 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 27/2613 68/18639 0.397058823529412 2.83229215911393 1.55732399437094e-07 9.35135979477025e-06 GO:0003713 transcription coactivator activity 67/2613 256/18639 0.26171875 1.86688701923077 1.8125681577976e-07 1.03464618899989e-05 GO:0016860 intramolecular oxidoreductase activity 23/2613 53/18639 0.433962264150943 3.09553105300782 1.8871421369546e-07 1.03464618899989e-05 GO:0009055 electron transfer activity 38/2613 116/18639 0.327586206896552 2.33673146205313 2.18468331345066e-07 1.10953956808933e-05 GO:0061775 cohesin loader activity 46/2613 153/18639 0.300653594771242 2.14461628509039 2.19972158621992e-07 1.10953956808933e-05 GO:0140658 ATP-dependent chromatin remodeler activity 47/2613 158/18639 0.29746835443038 2.12189539159122 2.31760680144621e-07 1.12403929870141e-05 GO:0140713 histone chaperone activity 48/2613 164/18639 0.292682926829268 2.0877600739268 2.96683331601654e-07 1.38562104129513e-05 GO:0000510 H3-H4 histone complex chaperone activity 45/2613 151/18639 0.298013245033113 2.12578219447845 3.9186068450387e-07 1.58978016156159e-05 GO:0140584 chromatin extrusion motor activity 45/2613 151/18639 0.298013245033113 2.12578219447845 3.9186068450387e-07 1.58978016156159e-05 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 45/2613 151/18639 0.298013245033113 2.12578219447845 3.9186068450387e-07 1.58978016156159e-05 GO:0140849 ATP-dependent H2AZ histone chaperone activity 45/2613 151/18639 0.298013245033113 2.12578219447845 3.9186068450387e-07 1.58978016156159e-05 GO:0008094 ATP-dependent activity, acting on DNA 57/2613 210/18639 0.271428571428571 1.93614892570116 4.03433506502544e-07 1.58978016156159e-05 GO:0003954 NADH dehydrogenase activity 20/2613 44/18639 0.454545454545455 3.24235466026511 4.74043857131859e-07 1.73629547992442e-05 GO:0015616 DNA translocase activity 45/2613 152/18639 0.296052631578947 2.11179678530425 4.81921822342227e-07 1.73629547992442e-05 GO:0140674 ATP-dependent histone chaperone activity 45/2613 152/18639 0.296052631578947 2.11179678530425 4.81921822342227e-07 1.73629547992442e-05 GO:0048027 mRNA 5'-UTR binding 14/2613 24/18639 0.583333333333333 4.16102181400689 5.36326619792336e-07 1.87863296543926e-05 GO:0008137 NADH dehydrogenase (ubiquinone) activity 19/2613 41/18639 0.463414634146341 3.30562011705077 6.32318823775352e-07 2.06149019472635e-05 GO:0061650 ubiquitin-like protein conjugating enzyme activity 19/2613 41/18639 0.463414634146341 3.30562011705077 6.32318823775352e-07 2.06149019472635e-05 GO:0015035 protein-disulfide reductase activity 17/2613 34/18639 0.5 3.56659012629162 6.37574287028767e-07 2.06149019472635e-05 GO:0140097 catalytic activity, acting on DNA 80/2613 336/18639 0.238095238095238 1.69837625061506 8.82726494635276e-07 2.78279527433771e-05 GO:0003689 DNA clamp loader activity 46/2613 160/18639 0.2875 2.05078932261768 9.08241293179431e-07 2.79339578219332e-05 GO:0003712 transcription coregulator activity 108/2613 495/18639 0.218181818181818 1.55633023692725 1.2275490008056e-06 3.68556973813302e-05 GO:0043024 ribosomal small subunit binding 12/2613 20/18639 0.6 4.27990815154994 2.36341962753749e-06 6.93086546587157e-05 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 23/2613 60/18639 0.383333333333333 2.73438576349024 2.62540887694231e-06 7.52418316778239e-05 GO:0022853 active monoatomic ion transmembrane transporter activity 36/2613 118/18639 0.305084745762712 2.17622448383895 3.01698247127656e-06 8.45425532506608e-05 GO:0051539 4 iron, 4 sulfur cluster binding 19/2613 45/18639 0.422222222222222 3.01178721775737 3.59188062930035e-06 9.84643798597335e-05 GO:0016741 transferase activity, transferring one-carbon groups 55/2613 215/18639 0.255813953488372 1.8247670413585 4.65589386258921e-06 0.000124916641717553 GO:0031720 haptoglobin binding 8/2613 10/18639 0.8 5.70654420206659 5.10238363027009e-06 0.000134043869953554 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 22/2613 58/18639 0.379310344827586 2.70568906132468 5.28402015239992e-06 0.000135982641064822 GO:0008173 RNA methyltransferase activity 24/2613 67/18639 0.358208955223881 2.55516904570146 6.42494021576833e-06 0.000162036992241677 GO:0051536 iron-sulfur cluster binding 26/2613 76/18639 0.342105263157895 2.44029850746269 7.10136534821169e-06 0.000175584739295979 GO:0005048 signal sequence binding 20/2613 51/18639 0.392156862745098 2.79732558924833 7.7899296916321e-06 0.000188905795022078 GO:0140517 protein-RNA adaptor activity 12/2613 22/18639 0.545454545454545 3.89082559231813 9.22695231723022e-06 0.000206931340599097 GO:0051540 metal cluster binding 26/2613 77/18639 0.337662337662338 2.40860631905408 9.30322322441242e-06 0.000206931340599097 GO:0055106 ubiquitin-protein transferase regulator activity 16/2613 36/18639 0.444444444444444 3.17030233448144 9.51785706165552e-06 0.000206931340599097 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 16/2613 36/18639 0.444444444444444 3.17030233448144 9.51785706165552e-06 0.000206931340599097 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 16/2613 36/18639 0.444444444444444 3.17030233448144 9.51785706165552e-06 0.000206931340599097 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 16/2613 36/18639 0.444444444444444 3.17030233448144 9.51785706165552e-06 0.000206931340599097 GO:0004532 RNA exonuclease activity 17/2613 40/18639 0.425 3.03160160734788 1.04832192818693e-05 0.00022032232524062 GO:0015036 disulfide oxidoreductase activity 17/2613 40/18639 0.425 3.03160160734788 1.04832192818693e-05 0.00022032232524062 GO:0051087 protein-folding chaperone binding 38/2613 134/18639 0.283582089552239 2.02284216118032 1.10562187361793e-05 0.000225157554731168 GO:0031625 ubiquitin protein ligase binding 70/2613 302/18639 0.231788079470199 1.65338615126102 1.1070395236584e-05 0.000225157554731168 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 15/2613 33/18639 0.454545454545455 3.24235466026511 1.29370470383229e-05 0.000258946290719447 GO:0004386 helicase activity 42/2613 155/18639 0.270967741935484 1.93286174586126 1.34888884282041e-05 0.000265773254811958 GO:0015399 primary active transmembrane transporter activity 44/2613 166/18639 0.265060240963855 1.89072247658833 1.55736188995709e-05 0.000302128206651675 GO:0044389 ubiquitin-like protein ligase binding 73/2613 322/18639 0.226708074534162 1.61714956036825 1.63284945616142e-05 0.000311973206699932 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 44/2613 167/18639 0.263473053892216 1.87940078511175 1.83142788888183e-05 0.000344691129534326 GO:0042393 histone binding 59/2613 247/18639 0.238866396761134 1.70387706438223 2.06660311956735e-05 0.000383233313790357 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 20/2613 54/18639 0.37037037037037 2.64191861206787 2.11878634546983e-05 0.000387215881396733 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 16/2613 38/18639 0.421052631578947 3.00344431687715 2.19372990281107e-05 0.000395184772492109 GO:0016859 cis-trans isomerase activity 17/2613 42/18639 0.404761904761905 2.8872396260456 2.27678832011232e-05 0.000404370432628399 GO:0061631 ubiquitin conjugating enzyme activity 15/2613 35/18639 0.428571428571429 3.0570772511071 3.07173206847167e-05 0.000537979741436497 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 16/2613 39/18639 0.41025641025641 2.92643292413671 3.23769825131404e-05 0.00055927910889137 GO:0031369 translation initiation factor binding 14/2613 32/18639 0.4375 3.12076636050517 4.26967650690936e-05 0.000717874943361693 GO:0140142 nucleocytoplasmic carrier activity 14/2613 32/18639 0.4375 3.12076636050517 4.26967650690936e-05 0.000717874943361693 GO:0055105 ubiquitin-protein transferase inhibitor activity 9/2613 15/18639 0.6 4.27990815154994 4.63163153319589e-05 0.000768485179389475 GO:0000287 magnesium ion binding 54/2613 230/18639 0.234782608695652 1.6747466679978 7.42491360473736e-05 0.00121595013708751 GO:0017069 snRNA binding 19/2613 54/18639 0.351851851851852 2.50982268146447 7.67078170850427e-05 0.00124010970954152 GO:0097177 mitochondrial ribosome binding 7/2613 10/18639 0.7 4.99322617680827 8.58037014370437e-05 0.00135526165866859 GO:0008168 methyltransferase activity 49/2613 204/18639 0.240196078431373 1.7133619234146 8.59801210892046e-05 0.00135526165866859 GO:0003724 RNA helicase activity 24/2613 77/18639 0.311688311688312 2.22332890989607 8.80022385437296e-05 0.00137001015806967 GO:0008187 poly-pyrimidine tract binding 13/2613 30/18639 0.433333333333333 3.0910447761194 9.04532778347028e-05 0.00139099491889708 GO:0008186 ATP-dependent activity, acting on RNA 24/2613 79/18639 0.30379746835443 2.1670421020506 0.00013774188126049 0.00208829459481311 GO:0000175 3'-5'-RNA exonuclease activity 14/2613 35/18639 0.4 2.8532721010333 0.00013910923549905 0.00208829459481311 GO:0004860 protein kinase inhibitor activity 25/2613 84/18639 0.297619047619048 2.12297031326882 0.000145362983699539 0.0021565026170014 GO:0003725 double-stranded RNA binding 23/2613 75/18639 0.306666666666667 2.18750861079219 0.00016099509658931 0.00236063740464094 GO:0019210 kinase inhibitor activity 26/2613 90/18639 0.288888888888889 2.06069651741294 0.00018484272699779 0.00267915722694498 GO:0070717 poly-purine tract binding 13/2613 32/18639 0.40625 2.89785447761194 0.000199626866841963 0.00284728474400284 GO:0005344 oxygen carrier activity 8/2613 14/18639 0.571428571428571 4.07610300147614 0.000200958241250002 0.00284728474400284 GO:0034511 U3 snoRNA binding 7/2613 11/18639 0.636363636363636 4.53929652437115 0.000207274801691023 0.00290415027702645 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 32/2613 122/18639 0.262295081967213 1.87099809903823 0.000261814258109576 0.00359395982423782 GO:0140318 protein transporter activity 15/2613 41/18639 0.365853658536585 2.6097000924085 0.000262208012553434 0.00359395982423782 GO:0019208 phosphatase regulator activity 31/2613 117/18639 0.264957264957265 1.88998793017163 0.000267125723833617 0.00359562985762721 GO:0017056 structural constituent of nuclear pore 11/2613 25/18639 0.44 3.13859931113662 0.000268032677729546 0.00359562985762721 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 33/2613 128/18639 0.2578125 1.83902303386912 0.000298726391606209 0.00396519978753084 GO:0019001 guanyl nucleotide binding 81/2613 400/18639 0.2025 1.44446900114811 0.000345441548287061 0.00449074012773179 GO:0032561 guanyl ribonucleotide binding 81/2613 400/18639 0.2025 1.44446900114811 0.000345441548287061 0.00449074012773179 GO:0008649 rRNA methyltransferase activity 10/2613 22/18639 0.454545454545455 3.24235466026511 0.000370356750093499 0.00471737234210003 GO:0070034 telomerase RNA binding 10/2613 22/18639 0.454545454545455 3.24235466026511 0.000370356750093499 0.00471737234210003 GO:0051117 ATPase binding 24/2613 84/18639 0.285714285714286 2.03805150073807 0.000385339517238319 0.0048591313123752 GO:0005525 GTP binding 77/2613 378/18639 0.203703703703704 1.45305523663733 0.000396495434045579 0.00495030437951955 GO:0008175 tRNA methyltransferase activity 13/2613 34/18639 0.382352941176471 2.72739244951712 0.000406003481130341 0.00501931754613098 GO:0004601 peroxidase activity 18/2613 57/18639 0.315789473684211 2.25258323765786 0.000543234686243036 0.00658766652061278 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 33/2613 132/18639 0.25 1.78329506314581 0.000543312702730951 0.00658766652061278 GO:0008171 O-methyltransferase activity 10/2613 23/18639 0.434782608695652 3.10138271851445 0.000573320687741185 0.00682035270982674 GO:0140102 catalytic activity, acting on a rRNA 10/2613 23/18639 0.434782608695652 3.10138271851445 0.000573320687741185 0.00682035270982674 GO:0008320 protein transmembrane transporter activity 11/2613 27/18639 0.407407407407407 2.90611047327465 0.000598935924498312 0.00705848785787262 GO:0019205 nucleobase-containing compound kinase activity 15/2613 44/18639 0.340909090909091 2.43176599519883 0.000629363467075713 0.00734840122205995 GO:0043023 ribosomal large subunit binding 8/2613 16/18639 0.5 3.56659012629162 0.000662716839952123 0.00766684344201492 GO:0008408 3'-5' exonuclease activity 18/2613 58/18639 0.310344827586207 2.21374559562928 0.000685778196739019 0.00786151187352639 GO:0016874 ligase activity 39/2613 167/18639 0.233532934131737 1.66583251407633 0.000775329808272955 0.00880802602010988 GO:0016651 oxidoreductase activity, acting on NAD(P)H 24/2613 88/18639 0.272727272727273 1.94541279615906 0.000806665243073219 0.00908218635281544 GO:0051059 NF-kappaB binding 12/2613 32/18639 0.375 2.67494259471871 0.000827380457922667 0.00912868697087776 GO:0009982 pseudouridine synthase activity 7/2613 13/18639 0.538461538461538 3.84094321292944 0.000832513086162524 0.00912868697087776 GO:0031994 insulin-like growth factor I binding 7/2613 13/18639 0.538461538461538 3.84094321292944 0.000832513086162524 0.00912868697087776 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 18/2613 59/18639 0.305084745762712 2.17622448383895 0.000859263349300777 0.0092956002696105 GO:0016866 intramolecular transferase activity 11/2613 28/18639 0.392857142857143 2.80232081351484 0.000862478375530871 0.0092956002696105 GO:0001094 TFIID-class transcription factor complex binding 6/2613 10/18639 0.6 4.27990815154994 0.000953807202254607 0.0101928040851107 GO:0004527 exonuclease activity 23/2613 84/18639 0.273809523809524 1.95313268820732 0.000967371089030985 0.0102508818762023 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 18/2613 60/18639 0.3 2.13995407577497 0.00106893125854559 0.0112326859752166 GO:0004857 enzyme inhibitor activity 81/2613 416/18639 0.194711538461538 1.38891250110395 0.00117502214131098 0.0122454786792822 GO:0072542 protein phosphatase activator activity 9/2613 21/18639 0.428571428571429 3.0570772511071 0.00122780569495857 0.0126906801749406 GO:0008139 nuclear localization sequence binding 10/2613 25/18639 0.4 2.8532721010333 0.0012548744983407 0.0127612640516744 GO:0019211 phosphatase activator activity 10/2613 25/18639 0.4 2.8532721010333 0.0012548744983407 0.0127612640516744 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 18/2613 61/18639 0.295081967213115 2.104872861418 0.0013206281752722 0.013322497032146 GO:0019888 protein phosphatase regulator activity 27/2613 107/18639 0.252336448598131 1.79996137214717 0.00143273752347396 0.0143387461674656 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 15/2613 48/18639 0.3125 2.22911882893226 0.0017306774439671 0.0169679550453967 GO:0003746 translation elongation factor activity 8/2613 18/18639 0.444444444444444 3.17030233448144 0.00173581776435859 0.0169679550453967 GO:0098641 cadherin binding involved in cell-cell adhesion 8/2613 18/18639 0.444444444444444 3.17030233448144 0.00173581776435859 0.0169679550453967 GO:0008143 poly(A) binding 10/2613 26/18639 0.384615384615385 2.74353086637817 0.00178540005671764 0.0173183805501612 GO:1990948 ubiquitin ligase inhibitor activity 6/2613 11/18639 0.545454545454545 3.89082559231813 0.0018496460829309 0.0178046084776784 GO:0061980 regulatory RNA binding 17/2613 58/18639 0.293103448275862 2.09075972920543 0.00192750686382299 0.0184135314793999 GO:0031072 heat shock protein binding 31/2613 131/18639 0.236641221374046 1.68800448725252 0.00204097455934046 0.0193508941302881 GO:0003714 transcription corepressor activity 44/2613 204/18639 0.215686274509804 1.53852907408658 0.00208240183900644 0.0195963337237845 GO:0003925 G protein activity 16/2613 54/18639 0.296296296296296 2.11353488965429 0.00228862366936609 0.0213774403486714 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 13/2613 40/18639 0.325 2.31828358208955 0.00233197163968269 0.0216221782179402 GO:0140297 DNA-binding transcription factor binding 91/2613 488/18639 0.186475409836066 1.33016271103499 0.00239975347209723 0.0220882418125154 GO:0008266 poly(U) RNA binding 10/2613 27/18639 0.37037037037037 2.64191861206787 0.00248332013449372 0.0226917876057723 GO:0003756 protein disulfide isomerase activity 8/2613 19/18639 0.421052631578947 3.00344431687715 0.00263273770834297 0.0235452641859609 GO:0005520 insulin-like growth factor binding 8/2613 19/18639 0.421052631578947 3.00344431687715 0.00263273770834297 0.0235452641859609 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 8/2613 19/18639 0.421052631578947 3.00344431687715 0.00263273770834297 0.0235452641859609 GO:0022884 macromolecule transmembrane transporter activity 11/2613 32/18639 0.34375 2.45203071182549 0.00303399602371551 0.026942739337361 GO:0019887 protein kinase regulator activity 52/2613 255/18639 0.203921568627451 1.45460930640913 0.0031250706935488 0.0275574415703849 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 14/2613 46/18639 0.304347826086957 2.17096790296012 0.00320512063070662 0.0279836187367717 GO:0005049 nuclear export signal receptor activity 6/2613 12/18639 0.5 3.56659012629162 0.00326216649825966 0.0279836187367717 GO:0016423 tRNA (guanine) methyltransferase activity 6/2613 12/18639 0.5 3.56659012629162 0.00326216649825966 0.0279836187367717 GO:1990247 N6-methyladenosine-containing RNA reader activity 6/2613 12/18639 0.5 3.56659012629162 0.00326216649825966 0.0279836187367717 GO:0022804 active transmembrane transporter activity 85/2613 457/18639 0.185995623632385 1.32674030956143 0.0035107635586218 0.0299126543744736 GO:0001091 RNA polymerase II general transcription initiation factor binding 9/2613 24/18639 0.375 2.67494259471871 0.00368195965806501 0.0311607458310066 GO:0031492 nucleosomal DNA binding 13/2613 42/18639 0.30952380952381 2.20788912579957 0.00377488625556614 0.0313363421037731 GO:0035198 miRNA binding 13/2613 42/18639 0.30952380952381 2.20788912579957 0.00377488625556614 0.0313363421037731 GO:0017070 U6 snRNA binding 7/2613 16/18639 0.4375 3.12076636050517 0.00377725931782197 0.0313363421037731 GO:0000339 RNA cap binding 8/2613 20/18639 0.4 2.8532721010333 0.00385418098239996 0.0315592351870542 GO:0061608 nuclear import signal receptor activity 8/2613 20/18639 0.4 2.8532721010333 0.00385418098239996 0.0315592351870542 GO:1990518 single-stranded 3'-5' DNA helicase activity 14/2613 47/18639 0.297872340425532 2.12477709651416 0.00398614046287432 0.0324291814431259 GO:0003697 single-stranded DNA binding 28/2613 121/18639 0.231404958677686 1.65065328158951 0.00456620416778068 0.0366750538571429 GO:0004540 RNA nuclease activity 28/2613 121/18639 0.231404958677686 1.65065328158951 0.00456620416778068 0.0366750538571429 GO:0036121 double-stranded DNA helicase activity 14/2613 48/18639 0.291666666666667 2.08051090700344 0.00491486052948317 0.0389788624382282 GO:0043138 3'-5' DNA helicase activity 14/2613 48/18639 0.291666666666667 2.08051090700344 0.00491486052948317 0.0389788624382282 GO:0140296 general transcription initiation factor binding 15/2613 53/18639 0.283018867924528 2.01882459978771 0.00500599447995684 0.0394534939951598 GO:0016835 carbon-oxygen lyase activity 20/2613 79/18639 0.253164556962025 1.8058684183755 0.00537879382860984 0.0421283168812237 GO:0003678 DNA helicase activity 19/2613 74/18639 0.256756756756757 1.83149222701462 0.00558276692391308 0.0431893809267141 GO:0031491 nucleosome binding 19/2613 74/18639 0.256756756756757 1.83149222701462 0.00558276692391308 0.0431893809267141 GO:0004659 prenyltransferase activity 7/2613 17/18639 0.411764705882353 2.93719186871074 0.00565235671392512 0.0431977079773308 GO:0016018 cyclosporin A binding 7/2613 17/18639 0.411764705882353 2.93719186871074 0.00565235671392512 0.0431977079773308 GO:0001046 core promoter sequence-specific DNA binding 13/2613 44/18639 0.295454545454545 2.10753052917232 0.00586621239597187 0.0443293468090437 GO:0019207 kinase regulator activity 56/2613 287/18639 0.195121951219512 1.39184004928453 0.00591844337638571 0.0443293468090437 GO:0035925 mRNA 3'-UTR AU-rich region binding 10/2613 30/18639 0.333333333333333 2.37772675086108 0.00594873906880437 0.0443293468090437 GO:0060590 ATPase regulator activity 14/2613 49/18639 0.285714285714286 2.03805150073807 0.00601047573907003 0.0443293468090437 GO:0036002 pre-mRNA binding 16/2613 59/18639 0.271186440677966 1.9344217634124 0.00601135472192425 0.0443293468090437 GO:0070063 RNA polymerase binding 16/2613 59/18639 0.271186440677966 1.9344217634124 0.00601135472192425 0.0443293468090437 GO:0016407 acetyltransferase activity 23/2613 96/18639 0.239583333333333 1.7089911021814 0.00617191643865437 0.0452487594717626 GO:0008017 microtubule binding 54/2613 276/18639 0.195652173913043 1.3956222233315 0.00641348363332049 0.0467479934197522 GO:0061791 GTPase motor activity 12/2613 40/18639 0.3 2.13995407577497 0.00698774391958011 0.0503516861862316 GO:1990606 membrane scission GTPase motor activity 12/2613 40/18639 0.3 2.13995407577497 0.00698774391958011 0.0503516861862316 GO:0001098 basal transcription machinery binding 16/2613 60/18639 0.266666666666667 1.90218140068886 0.0071535671179275 0.0509641137610541 GO:0001099 basal RNA polymerase II transcription machinery binding 16/2613 60/18639 0.266666666666667 1.90218140068886 0.0071535671179275 0.0509641137610541 GO:0016829 lyase activity 41/2613 200/18639 0.205 1.46230195177956 0.00729510332728815 0.0512258855944863 GO:0016427 tRNA (cytidine) methyltransferase activity 5/2613 10/18639 0.5 3.56659012629162 0.0073528035627296 0.0512258855944863 GO:0140940 histone H2A methyltransferase activity 5/2613 10/18639 0.5 3.56659012629162 0.0073528035627296 0.0512258855944863 GO:1990259 histone H2AQ104 methyltransferase activity 5/2613 10/18639 0.5 3.56659012629162 0.0073528035627296 0.0512258855944863 GO:0034062 5'-3' RNA polymerase activity 8/2613 22/18639 0.363636363636364 2.59388372821209 0.00755554777609942 0.0520630915063462 GO:0097747 RNA polymerase activity 8/2613 22/18639 0.363636363636364 2.59388372821209 0.00755554777609942 0.0520630915063462 GO:0032182 ubiquitin-like protein binding 27/2613 120/18639 0.225 1.60496555683123 0.00782203533624193 0.0536064486902232 GO:1901611 phosphatidylglycerol binding 7/2613 18/18639 0.388888888888889 2.77401454267126 0.0081446996818311 0.0555160340475082 GO:0016877 ligase activity, forming carbon-sulfur bonds 12/2613 41/18639 0.292682926829268 2.0877600739268 0.00864485292100138 0.0586083845880792 GO:0001671 ATPase activator activity 9/2613 27/18639 0.333333333333333 2.37772675086108 0.00891938149688838 0.0601462035699265 GO:0015078 proton transmembrane transporter activity 38/2613 185/18639 0.205405405405405 1.46519378161169 0.00921351148167711 0.0617991381829512 GO:0043130 ubiquitin binding 23/2613 100/18639 0.23 1.64063145809414 0.0102716762219115 0.0685321889726475 GO:0061749 forked DNA-dependent helicase activity 13/2613 47/18639 0.276595744680851 1.973007303906 0.0106272033391789 0.0705310705826556 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 45/2613 229/18639 0.196506550218341 1.40171664352072 0.0111105327036979 0.0733527839757228 GO:0051537 2 iron, 2 sulfur cluster binding 9/2613 28/18639 0.321428571428571 2.29280793833033 0.011541504837243 0.075801237498768 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 5/2613 11/18639 0.454545454545455 3.24235466026511 0.0119387681292285 0.0776019928399853 GO:0070990 snRNP binding 5/2613 11/18639 0.454545454545455 3.24235466026511 0.0119387681292285 0.0776019928399853 GO:0017116 single-stranded DNA helicase activity 15/2613 58/18639 0.258620689655172 1.84478799635773 0.0121032733945706 0.0781622888145967 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 6/2613 15/18639 0.4 2.8532721010333 0.0121489362471538 0.0781622888145967 GO:0015631 tubulin binding 70/2613 385/18639 0.181818181818182 1.29694186410604 0.0125844266430308 0.0805531065830553 GO:0009378 four-way junction helicase activity 13/2613 48/18639 0.270833333333333 1.93190298507463 0.0127489306684944 0.0811939473382396 GO:0050699 WW domain binding 8/2613 24/18639 0.333333333333333 2.37772675086108 0.0134377588959348 0.085150823958662 GO:0016209 antioxidant activity 20/2613 86/18639 0.232558139534884 1.65887912850773 0.0141639910025119 0.0893039632708376 GO:0003924 GTPase activity 61/2613 331/18639 0.18429003021148 1.3145740042525 0.0143917894474786 0.0902887885237338 GO:0051287 NAD binding 14/2613 54/18639 0.259259259259259 1.84934302844751 0.0147301437663332 0.0919540162838917 GO:0004518 nuclease activity 41/2613 209/18639 0.196172248803828 1.39933201127231 0.0152218924195453 0.0945556962613135 GO:0030332 cyclin binding 10/2613 34/18639 0.294117647058824 2.09799419193625 0.0153549954906118 0.0947386933123586 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 7/2613 20/18639 0.35 2.49661308840413 0.0154016115218347 0.0947386933123586 GO:0019842 vitamin binding 31/2613 150/18639 0.206666666666667 1.47419058553387 0.0159709491448126 0.0977639168524693 GO:0019787 ubiquitin-like protein transferase activity 84/2613 479/18639 0.175365344467641 1.25091261214403 0.0166251827909864 0.10127707970741 GO:0003688 DNA replication origin binding 6/2613 16/18639 0.375 2.67494259471871 0.0171719424047529 0.10214065741695 GO:0005324 long-chain fatty acid transmembrane transporter activity 6/2613 16/18639 0.375 2.67494259471871 0.0171719424047529 0.10214065741695 GO:0008142 oxysterol binding 6/2613 16/18639 0.375 2.67494259471871 0.0171719424047529 0.10214065741695 GO:0034450 ubiquitin-ubiquitin ligase activity 6/2613 16/18639 0.375 2.67494259471871 0.0171719424047529 0.10214065741695 GO:0097027 ubiquitin-protein transferase activator activity 6/2613 16/18639 0.375 2.67494259471871 0.0171719424047529 0.10214065741695 GO:0098632 cell-cell adhesion mediator activity 14/2613 55/18639 0.254545454545455 1.81571860974846 0.0172792705970228 0.10229652686782 GO:0000340 RNA 7-methylguanosine cap binding 5/2613 12/18639 0.416666666666667 2.97215843857635 0.0181363407227777 0.106033056811196 GO:0036009 protein-glutamine N-methyltransferase activity 5/2613 12/18639 0.416666666666667 2.97215843857635 0.0181363407227777 0.106033056811196 GO:0031490 chromatin DNA binding 27/2613 128/18639 0.2109375 1.50465520952928 0.018162680627453 0.106033056811196 GO:0016836 hydro-lyase activity 15/2613 61/18639 0.245901639344262 1.75406071784834 0.0191500313720376 0.111281979539813 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 63/2613 349/18639 0.180515759312321 1.28765144960672 0.0197930470144171 0.114490973785229 GO:0019212 phosphatase inhibitor activity 14/2613 56/18639 0.25 1.78329506314581 0.0201505687200517 0.116026790666599 GO:0016755 aminoacyltransferase activity 86/2613 496/18639 0.173387096774194 1.23680141476242 0.0202897383983951 0.116212911640814 GO:0070182 DNA polymerase binding 7/2613 21/18639 0.333333333333333 2.37772675086108 0.0203672113184931 0.116212911640814 GO:0030291 protein serine/threonine kinase inhibitor activity 12/2613 46/18639 0.260869565217391 1.86082963110867 0.0219211443580359 0.124516049709384 GO:0070006 metalloaminopeptidase activity 8/2613 26/18639 0.307692307692308 2.19482469310254 0.0221028069977475 0.124984931050043 GO:0004550 nucleoside diphosphate kinase activity 6/2613 17/18639 0.352941176470588 2.5175930303235 0.0234553527815681 0.13029603461479 GO:0032977 membrane insertase activity 6/2613 17/18639 0.352941176470588 2.5175930303235 0.0234553527815681 0.13029603461479 GO:0048038 quinone binding 6/2613 17/18639 0.352941176470588 2.5175930303235 0.0234553527815681 0.13029603461479 GO:0051787 misfolded protein binding 6/2613 17/18639 0.352941176470588 2.5175930303235 0.0234553527815681 0.13029603461479 GO:0043560 insulin receptor substrate binding 5/2613 13/18639 0.384615384615385 2.74353086637817 0.0261310995709066 0.144523318240847 GO:0002039 p53 binding 16/2613 69/18639 0.231884057971014 1.65407078320771 0.0270445851941404 0.148922366505725 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 6/2613 18/18639 0.333333333333333 2.37772675086108 0.0311106793314365 0.169829292800612 GO:0070628 proteasome binding 6/2613 18/18639 0.333333333333333 2.37772675086108 0.0311106793314365 0.169829292800612 GO:0098631 cell adhesion mediator activity 17/2613 76/18639 0.223684210526316 1.59557979334099 0.0320741088229422 0.174333841490216 GO:0042162 telomeric DNA binding 10/2613 38/18639 0.263157894736842 1.87715269804822 0.0328829909612353 0.17757196380899 GO:0050661 NADP binding 13/2613 54/18639 0.240740740740741 1.71724709784411 0.0329514984387816 0.17757196380899 GO:0004842 ubiquitin-protein transferase activity 77/2613 449/18639 0.171492204899777 1.22328480946305 0.0336133671539334 0.180367897791958 GO:0046625 sphingolipid binding 8/2613 28/18639 0.285714285714286 2.03805150073807 0.0340986102624558 0.18219638788541 GO:0008174 mRNA methyltransferase activity 5/2613 14/18639 0.357142857142857 2.54756437592259 0.0360621434759692 0.18869030258588 GO:0008474 palmitoyl-(protein) hydrolase activity 5/2613 14/18639 0.357142857142857 2.54756437592259 0.0360621434759692 0.18869030258588 GO:0016530 metallochaperone activity 5/2613 14/18639 0.357142857142857 2.54756437592259 0.0360621434759692 0.18869030258588 GO:0070742 C2H2 zinc finger domain binding 5/2613 14/18639 0.357142857142857 2.54756437592259 0.0360621434759692 0.18869030258588 GO:0098599 palmitoyl hydrolase activity 5/2613 14/18639 0.357142857142857 2.54756437592259 0.0360621434759692 0.18869030258588 GO:0140313 molecular sequestering activity 13/2613 55/18639 0.236363636363636 1.68602442333786 0.0378024261040879 0.196978757509318 GO:0016776 phosphotransferase activity, phosphate group as acceptor 10/2613 39/18639 0.256410256410256 1.82902057758545 0.0388511479919342 0.198370130565945 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0005528 FK506 binding 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0008190 eukaryotic initiation factor 4E binding 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0016783 sulfurtransferase activity 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0030957 Tat protein binding 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0031957 very long-chain fatty acid-CoA ligase activity 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0047429 nucleoside triphosphate diphosphatase activity 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:1990757 ubiquitin ligase activator activity 4/2613 10/18639 0.4 2.8532721010333 0.0400978913010616 0.198370130565945 GO:0015245 fatty acid transmembrane transporter activity 6/2613 19/18639 0.315789473684211 2.25258323765786 0.0402263724845461 0.198370130565945 GO:0016831 carboxy-lyase activity 9/2613 34/18639 0.264705882352941 1.88819477274262 0.0404291225657795 0.198370130565945 GO:0019825 oxygen binding 9/2613 34/18639 0.264705882352941 1.88819477274262 0.0404291225657795 0.198370130565945 GO:0106222 lncRNA binding 8/2613 29/18639 0.275862068965517 1.96777386278158 0.0414889969909589 0.202781493044958 GO:0046915 transition metal ion transmembrane transporter activity 11/2613 45/18639 0.244444444444444 1.74366628396479 0.0429740045689381 0.209228647727533 GO:0015179 L-amino acid transmembrane transporter activity 14/2613 62/18639 0.225806451612903 1.61071812155105 0.0453804374415296 0.220095121591418 GO:0016830 carbon-carbon lyase activity 12/2613 51/18639 0.235294117647059 1.678395353549 0.0463070600106086 0.223728745875009 GO:0000774 adenyl-nucleotide exchange factor activity 5/2613 15/18639 0.333333333333333 2.37772675086108 0.0480187470903768 0.229362273033959 GO:0004467 long-chain fatty acid-CoA ligase activity 5/2613 15/18639 0.333333333333333 2.37772675086108 0.0480187470903768 0.229362273033959 GO:0140776 protein-containing complex destabilizing activity 5/2613 15/18639 0.333333333333333 2.37772675086108 0.0480187470903768 0.229362273033959 GO:0015932 nucleobase-containing compound transmembrane transporter activity 13/2613 57/18639 0.228070175438596 1.62686567164179 0.0489807863367547 0.233074609700557 GO:0052745 inositol phosphate phosphatase activity 6/2613 20/18639 0.3 2.13995407577497 0.0508655557542795 0.241133330098295 GO:1901682 sulfur compound transmembrane transporter activity 14/2613 63/18639 0.222222222222222 1.58515116724072 0.0511054307539703 0.241363101800586 GO:0008170 N-methyltransferase activity 20/2613 98/18639 0.204081632653061 1.45575107195576 0.0515791498926396 0.242691447815741 GO:0004812 aminoacyl-tRNA ligase activity 10/2613 41/18639 0.24390243902439 1.73980006160567 0.0529290368075844 0.24628603473935 GO:0015175 neutral L-amino acid transmembrane transporter activity 10/2613 41/18639 0.24390243902439 1.73980006160567 0.0529290368075844 0.24628603473935 GO:0016875 ligase activity, forming carbon-oxygen bonds 10/2613 41/18639 0.24390243902439 1.73980006160567 0.0529290368075844 0.24628603473935 GO:0015101 organic cation transmembrane transporter activity 17/2613 81/18639 0.209876543209877 1.49708721350512 0.0550198412075229 0.253050359078162 GO:0000099 sulfur amino acid transmembrane transporter activity 4/2613 11/18639 0.363636363636364 2.59388372821209 0.0561888188278233 0.253050359078162 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 4/2613 11/18639 0.363636363636364 2.59388372821209 0.0561888188278233 0.253050359078162 GO:0005536 D-glucose binding 4/2613 11/18639 0.363636363636364 2.59388372821209 0.0561888188278233 0.253050359078162 GO:0008526 phosphatidylinositol transfer activity 4/2613 11/18639 0.363636363636364 2.59388372821209 0.0561888188278233 0.253050359078162 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 4/2613 11/18639 0.363636363636364 2.59388372821209 0.0561888188278233 0.253050359078162 GO:0019206 nucleoside kinase activity 4/2613 11/18639 0.363636363636364 2.59388372821209 0.0561888188278233 0.253050359078162 GO:0035252 UDP-xylosyltransferase activity 4/2613 11/18639 0.363636363636364 2.59388372821209 0.0561888188278233 0.253050359078162 GO:0042285 xylosyltransferase activity 4/2613 11/18639 0.363636363636364 2.59388372821209 0.0561888188278233 0.253050359078162 GO:0097110 scaffold protein binding 15/2613 70/18639 0.214285714285714 1.52853862555355 0.0588073030588514 0.263900388459828 GO:0016878 acid-thiol ligase activity 8/2613 31/18639 0.258064516129032 1.84082071034406 0.0592655480108785 0.264077229829392 GO:0072349 modified amino acid transmembrane transporter activity 8/2613 31/18639 0.258064516129032 1.84082071034406 0.0592655480108785 0.264077229829392 GO:0016410 N-acyltransferase activity 19/2613 94/18639 0.202127659574468 1.44181302977746 0.0615281401576128 0.273193608235034 GO:0005521 lamin binding 5/2613 16/18639 0.3125 2.22911882893226 0.0620400219474786 0.273540096768428 GO:0022858 alanine transmembrane transporter activity 5/2613 16/18639 0.3125 2.22911882893226 0.0620400219474786 0.273540096768428 GO:0035613 RNA stem-loop binding 6/2613 21/18639 0.285714285714286 2.03805150073807 0.0630648935285942 0.277090002576855 GO:0008276 protein methyltransferase activity 19/2613 95/18639 0.2 1.42663605051665 0.0672191580187284 0.294317216186169 GO:0019903 protein phosphatase binding 27/2613 144/18639 0.1875 1.33747129735936 0.0681370951013159 0.297304072397091 GO:0005385 zinc ion transmembrane transporter activity 7/2613 27/18639 0.259259259259259 1.84934302844751 0.0736829792390981 0.320393920070699 GO:0005095 GTPase inhibitor activity 4/2613 12/18639 0.333333333333333 2.37772675086108 0.0752150578803462 0.320426310767286 GO:0005527 macrolide binding 4/2613 12/18639 0.333333333333333 2.37772675086108 0.0752150578803462 0.320426310767286 GO:0016273 arginine N-methyltransferase activity 4/2613 12/18639 0.333333333333333 2.37772675086108 0.0752150578803462 0.320426310767286 GO:0016274 protein-arginine N-methyltransferase activity 4/2613 12/18639 0.333333333333333 2.37772675086108 0.0752150578803462 0.320426310767286 GO:0017166 vinculin binding 4/2613 12/18639 0.333333333333333 2.37772675086108 0.0752150578803462 0.320426310767286 GO:0034452 dynactin binding 4/2613 12/18639 0.333333333333333 2.37772675086108 0.0752150578803462 0.320426310767286 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 6/2613 22/18639 0.272727272727273 1.94541279615906 0.0768344832374632 0.325198996737014 GO:0046906 tetrapyrrole binding 28/2613 152/18639 0.184210526315789 1.31400688863375 0.0768511506959794 0.325198996737014 GO:0001221 transcription coregulator binding 22/2613 115/18639 0.191304347826087 1.36460839614636 0.0777610360650452 0.327260783831758 GO:0004029 aldehyde dehydrogenase (NAD+) activity 5/2613 17/18639 0.294117647058824 2.09799419193625 0.0781169674332746 0.327260783831758 GO:0070402 NADPH binding 5/2613 17/18639 0.294117647058824 2.09799419193625 0.0781169674332746 0.327260783831758 GO:0016790 thiolester hydrolase activity 10/2613 44/18639 0.227272727272727 1.62117733013255 0.0797352263248323 0.332934173495409 GO:0140416 transcription regulator inhibitor activity 8/2613 33/18639 0.242424242424242 1.72925581880806 0.0811980055506256 0.337923052803099 GO:0003774 cytoskeletal motor activity 28/2613 153/18639 0.183006535947712 1.30541860831589 0.0820082642410503 0.340172438184093 GO:0030170 pyridoxal phosphate binding 12/2613 56/18639 0.214285714285714 1.52853862555355 0.0848757818930533 0.350912658908656 GO:0005548 phospholipid transporter activity 14/2613 68/18639 0.205882352941176 1.46859593435537 0.0871436434667089 0.357941805900716 GO:0140223 general transcription initiation factor activity 14/2613 68/18639 0.205882352941176 1.46859593435537 0.0871436434667089 0.357941805900716 GO:0048029 monosaccharide binding 15/2613 74/18639 0.202702702702703 1.44591491606417 0.0875659069365013 0.358508469632883 GO:0020037 heme binding 26/2613 142/18639 0.183098591549296 1.30607525751524 0.0905940402493469 0.365238864874581 GO:0004602 glutathione peroxidase activity 6/2613 23/18639 0.260869565217391 1.86082963110867 0.0921586331676592 0.365238864874581 GO:0017134 fibroblast growth factor binding 6/2613 23/18639 0.260869565217391 1.86082963110867 0.0921586331676592 0.365238864874581 GO:0070577 lysine-acetylated histone binding 6/2613 23/18639 0.260869565217391 1.86082963110867 0.0921586331676592 0.365238864874581 GO:0030544 Hsp70 protein binding 11/2613 51/18639 0.215686274509804 1.53852907408658 0.0927860397324298 0.365238864874581 GO:0090482 vitamin transmembrane transporter activity 8/2613 34/18639 0.235294117647059 1.678395353549 0.0937422772382706 0.365238864874581 GO:0070279 vitamin B6 binding 12/2613 57/18639 0.210526315789474 1.50172215843858 0.0944477807080664 0.365238864874581 GO:0001618 virus receptor activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:0033192 calmodulin-dependent protein phosphatase activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:0140791 histone H2AXS140 phosphatase activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:1990439 MAP kinase serine/threonine phosphatase activity 16/2613 81/18639 0.197530864197531 1.40902325976953 0.0956708608056096 0.365238864874581 GO:0008080 N-acetyltransferase activity 14/2613 69/18639 0.202898550724638 1.44731193530674 0.0958927118122391 0.365238864874581 GO:0019003 GDP binding 15/2613 75/18639 0.2 1.42663605051665 0.0959432534941975 0.365238864874581 GO:0008525 phosphatidylcholine transporter activity 5/2613 18/18639 0.277777777777778 1.9814389590509 0.0961963090109047 0.365238864874581 GO:0017128 phospholipid scramblase activity 5/2613 18/18639 0.277777777777778 1.9814389590509 0.0961963090109047 0.365238864874581 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/2613 13/18639 0.307692307692308 2.19482469310254 0.0970301504623194 0.365238864874581 GO:0005338 nucleotide-sugar transmembrane transporter activity 4/2613 13/18639 0.307692307692308 2.19482469310254 0.0970301504623194 0.365238864874581 GO:0008253 5'-nucleotidase activity 4/2613 13/18639 0.307692307692308 2.19482469310254 0.0970301504623194 0.365238864874581 GO:0030955 potassium ion binding 4/2613 13/18639 0.307692307692308 2.19482469310254 0.0970301504623194 0.365238864874581 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/2613 13/18639 0.307692307692308 2.19482469310254 0.0970301504623194 0.365238864874581 GO:0140666 annealing activity 4/2613 13/18639 0.307692307692308 2.19482469310254 0.0970301504623194 0.365238864874581 GO:0140852 histone ubiquitin ligase activity 4/2613 13/18639 0.307692307692308 2.19482469310254 0.0970301504623194 0.365238864874581 GO:0004177 aminopeptidase activity 9/2613 40/18639 0.225 1.60496555683123 0.0984144932809157 0.368251264175771 GO:0050997 quaternary ammonium group binding 9/2613 40/18639 0.225 1.60496555683123 0.0984144932809157 0.368251264175771 GO:0016417 S-acyltransferase activity 7/2613 29/18639 0.241379310344828 1.72180212993389 0.101319650868394 0.378000235932086 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 16/2613 82/18639 0.195121951219512 1.39184004928453 0.104146577217122 0.385128545075634 GO:0033549 MAP kinase phosphatase activity 16/2613 82/18639 0.195121951219512 1.39184004928453 0.104146577217122 0.385128545075634 GO:0140272 exogenous protein binding 16/2613 82/18639 0.195121951219512 1.39184004928453 0.104146577217122 0.385128545075634 GO:0061659 ubiquitin-like protein ligase activity 61/2613 372/18639 0.163978494623656 1.16968815969779 0.105551888432039 0.389184009686551 GO:0140033 acetylation-dependent protein binding 6/2613 24/18639 0.25 1.78329506314581 0.108997371867188 0.40071628549424 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 16/2613 83/18639 0.192771084337349 1.37507089206424 0.113068132813133 0.413429704092359 GO:0042277 peptide binding 42/2613 249/18639 0.168674698795181 1.20318703055621 0.114480654153855 0.413429704092359 GO:0004864 protein phosphatase inhibitor activity 11/2613 53/18639 0.207547169811321 1.48047137317765 0.114929478220091 0.413429704092359 GO:0034212 protein N-acetyltransferase activity 11/2613 53/18639 0.207547169811321 1.48047137317765 0.114929478220091 0.413429704092359 GO:0008301 DNA binding, bending 5/2613 19/18639 0.263157894736842 1.87715269804822 0.116185572056033 0.413429704092359 GO:0008574 plus-end-directed microtubule motor activity 5/2613 19/18639 0.263157894736842 1.87715269804822 0.116185572056033 0.413429704092359 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5/2613 19/18639 0.263157894736842 1.87715269804822 0.116185572056033 0.413429704092359 GO:0046527 glucosyltransferase activity 5/2613 19/18639 0.263157894736842 1.87715269804822 0.116185572056033 0.413429704092359 GO:0050145 nucleoside monophosphate kinase activity 5/2613 19/18639 0.263157894736842 1.87715269804822 0.116185572056033 0.413429704092359 GO:0097001 ceramide binding 5/2613 19/18639 0.263157894736842 1.87715269804822 0.116185572056033 0.413429704092359 GO:0051020 GTPase binding 52/2613 315/18639 0.165079365079365 1.17754086709311 0.116199474944519 0.413429704092359 GO:0008514 organic anion transmembrane transporter activity 45/2613 269/18639 0.16728624535316 1.19328294188195 0.116389805672314 0.413429704092359 GO:0001968 fibronectin binding 7/2613 30/18639 0.233333333333333 1.66440872560276 0.11697908710553 0.414355698988971 GO:0044548 S100 protein binding 4/2613 14/18639 0.285714285714286 2.03805150073807 0.12141735325686 0.425298006824722 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/2613 14/18639 0.285714285714286 2.03805150073807 0.12141735325686 0.425298006824722 GO:1901612 cardiolipin binding 4/2613 14/18639 0.285714285714286 2.03805150073807 0.12141735325686 0.425298006824722 GO:1990825 sequence-specific mRNA binding 4/2613 14/18639 0.285714285714286 2.03805150073807 0.12141735325686 0.425298006824722 GO:0000993 RNA polymerase II complex binding 8/2613 36/18639 0.222222222222222 1.58515116724072 0.121930183987702 0.425911252101085 GO:0017018 myosin phosphatase activity 16/2613 84/18639 0.19047619047619 1.35870100049205 0.122433635154066 0.426488436268722 GO:0043175 RNA polymerase core enzyme binding 9/2613 42/18639 0.214285714285714 1.52853862555355 0.124875935173227 0.432383623998161 GO:0004722 protein serine/threonine phosphatase activity 19/2613 103/18639 0.184466019417476 1.31582936698137 0.125619626836478 0.432383623998161 GO:0140693 molecular condensate scaffold activity 10/2613 48/18639 0.208333333333333 1.48607921928817 0.126442798374744 0.432383623998161 GO:0015645 fatty acid ligase activity 6/2613 25/18639 0.24 1.71196326061998 0.127288531227775 0.432383623998161 GO:0015662 P-type ion transporter activity 6/2613 25/18639 0.24 1.71196326061998 0.127288531227775 0.432383623998161 GO:0017025 TBP-class protein binding 6/2613 25/18639 0.24 1.71196326061998 0.127288531227775 0.432383623998161 GO:0047617 fatty acyl-CoA hydrolase activity 6/2613 25/18639 0.24 1.71196326061998 0.127288531227775 0.432383623998161 GO:0120515 fatty acid-CoA ligase activity 6/2613 25/18639 0.24 1.71196326061998 0.127288531227775 0.432383623998161 GO:0140358 P-type transmembrane transporter activity 6/2613 25/18639 0.24 1.71196326061998 0.127288531227775 0.432383623998161 GO:0005506 iron ion binding 27/2613 154/18639 0.175324675324675 1.25062251181654 0.127554883526817 0.432383623998161 GO:0015297 antiporter activity 24/2613 135/18639 0.177777777777778 1.26812093379258 0.128889230586028 0.435735441739897 GO:0008327 methyl-CpG binding 7/2613 31/18639 0.225806451612903 1.61071812155105 0.133812202674804 0.451168950729752 GO:0043539 protein serine/threonine kinase activator activity 14/2613 73/18639 0.191780821917808 1.36800717172829 0.136085224816653 0.4576092493168 GO:0016779 nucleotidyltransferase activity 24/2613 136/18639 0.176470588235294 1.25879651516175 0.136754736711182 0.458637561151064 GO:0016791 phosphatase activity 45/2613 273/18639 0.164835164835165 1.1757989427335 0.137705525054418 0.459013684823644 GO:0015095 magnesium ion transmembrane transporter activity 5/2613 20/18639 0.25 1.78329506314581 0.137958910823284 0.459013684823644 GO:0016408 C-acyltransferase activity 5/2613 20/18639 0.25 1.78329506314581 0.137958910823284 0.459013684823644 GO:0004712 protein serine/threonine/tyrosine kinase activity 9/2613 43/18639 0.209302325581395 1.49299121565696 0.139396492083006 0.461419410985142 GO:0061630 ubiquitin protein ligase activity 57/2613 353/18639 0.161473087818697 1.15181664135197 0.139413795071641 0.461419410985142 GO:0016763 pentosyltransferase activity 10/2613 49/18639 0.204081632653061 1.45575107195576 0.140034294832169 0.462259805715616 GO:0016289 acyl-CoA hydrolase activity 6/2613 26/18639 0.230769230769231 1.6461185198269 0.146950250087567 0.477723705821019 GO:0030507 spectrin binding 6/2613 26/18639 0.230769230769231 1.6461185198269 0.146950250087567 0.477723705821019 GO:0120014 phospholipid transfer activity 6/2613 26/18639 0.230769230769231 1.6461185198269 0.146950250087567 0.477723705821019 GO:0008252 nucleotidase activity 4/2613 15/18639 0.266666666666667 1.90218140068886 0.148107755499217 0.477723705821019 GO:0015556 C4-dicarboxylate transmembrane transporter activity 4/2613 15/18639 0.266666666666667 1.90218140068886 0.148107755499217 0.477723705821019 GO:0030145 manganese ion binding 13/2613 68/18639 0.191176470588235 1.36369622475856 0.1496355466378 0.477723705821019 GO:1990841 promoter-specific chromatin binding 13/2613 68/18639 0.191176470588235 1.36369622475856 0.1496355466378 0.477723705821019 GO:0051219 phosphoprotein binding 17/2613 93/18639 0.182795698924731 1.30391466982704 0.150048426234076 0.477723705821019 GO:0043531 ADP binding 8/2613 38/18639 0.210526315789474 1.50172215843858 0.154054384475424 0.477723705821019 GO:0015605 organophosphate ester transmembrane transporter activity 10/2613 50/18639 0.2 1.42663605051665 0.154352578101908 0.477723705821019 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0005337 nucleoside transmembrane transporter activity 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0005522 profilin binding 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0016868 intramolecular phosphotransferase activity 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0031434 mitogen-activated protein kinase kinase binding 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0033204 ribonuclease P RNA binding 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0051880 G-quadruplex DNA binding 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0098505 G-rich strand telomeric DNA binding 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:1905394 retromer complex binding 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/2613 10/18639 0.3 2.13995407577497 0.154947657161615 0.477723705821019 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/2613 21/18639 0.238095238095238 1.69837625061506 0.161363291227875 0.494683499031806 GO:0051010 microtubule plus-end binding 5/2613 21/18639 0.238095238095238 1.69837625061506 0.161363291227875 0.494683499031806 GO:0005319 lipid transporter activity 30/2613 178/18639 0.168539325842697 1.20222139088482 0.16162537795488 0.494683499031806 GO:0005507 copper ion binding 12/2613 63/18639 0.19047619047619 1.35870100049205 0.164833746152411 0.503281728567047 GO:0016405 CoA-ligase activity 6/2613 27/18639 0.222222222222222 1.58515116724072 0.167883756044272 0.51135607819282 GO:0140303 intramembrane lipid transporter activity 9/2613 45/18639 0.2 1.42663605051665 0.170862842390827 0.51917601025261 GO:0008028 monocarboxylic acid transmembrane transporter activity 13/2613 70/18639 0.185714285714286 1.32473347547974 0.175099587693926 0.530770625197214 GO:0004708 MAP kinase kinase activity 4/2613 16/18639 0.25 1.78329506314581 0.176797000016463 0.532078799572219 GO:0030275 LRR domain binding 4/2613 16/18639 0.25 1.78329506314581 0.176797000016463 0.532078799572219 GO:0140328 floppase activity 4/2613 16/18639 0.25 1.78329506314581 0.176797000016463 0.532078799572219 GO:0033218 amide binding 40/2613 247/18639 0.161943319838057 1.1551708911066 0.183105429344629 0.549752253341851 GO:0140299 molecular sensor activity 13/2613 71/18639 0.183098591549296 1.30607525751524 0.188579975763926 0.55909834031845 GO:0046943 carboxylic acid transmembrane transporter activity 31/2613 188/18639 0.164893617021277 1.17621589271319 0.189083979386823 0.55909834031845 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 7/2613 34/18639 0.205882352941176 1.46859593435537 0.190727635785197 0.55909834031845 GO:0004721 phosphoprotein phosphatase activity 29/2613 175/18639 0.165714285714286 1.18206987042808 0.190897325232427 0.55909834031845 GO:0002162 dystroglycan binding 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0010854 adenylate cyclase regulator activity 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0015173 aromatic amino acid transmembrane transporter activity 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0019107 myristoyltransferase activity 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0045294 alpha-catenin binding 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0047676 arachidonate-CoA ligase activity 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/2613 11/18639 0.272727272727273 1.94541279615906 0.191982221536787 0.55909834031845 GO:0160215 deacylase activity 12/2613 65/18639 0.184615384615385 1.31689481586152 0.192909837037982 0.560505309919113 GO:0044325 transmembrane transporter binding 23/2613 136/18639 0.169117647058824 1.20634666036334 0.19492040578794 0.563749155272002 GO:0140789 histone phosphatase activity 23/2613 136/18639 0.169117647058824 1.20634666036334 0.19492040578794 0.563749155272002 GO:0005342 organic acid transmembrane transporter activity 31/2613 189/18639 0.164021164021164 1.16999252820148 0.197467834323048 0.569809929247971 GO:0016251 RNA polymerase II general transcription initiation factor activity 10/2613 53/18639 0.188679245283019 1.34588306652514 0.201356325539528 0.578383431675044 GO:1901505 carbohydrate derivative transmembrane transporter activity 10/2613 53/18639 0.188679245283019 1.34588306652514 0.201356325539528 0.578383431675044 GO:0016922 nuclear receptor binding 23/2613 137/18639 0.167883211678832 1.1975412102877 0.205012925975006 0.585714954401428 GO:0140938 histone H3 methyltransferase activity 9/2613 47/18639 0.191489361702128 1.36592813347339 0.205283851521822 0.585714954401428 GO:0019902 phosphatase binding 31/2613 190/18639 0.163157894736842 1.1638346727899 0.206038888818181 0.585714954401428 GO:0042626 ATPase-coupled transmembrane transporter activity 17/2613 98/18639 0.173469387755102 1.2373884111624 0.206605775712713 0.585714954401428 GO:0004549 tRNA-specific ribonuclease activity 4/2613 17/18639 0.235294117647059 1.678395353549 0.207160086965136 0.585714954401428 GO:0005092 GDP-dissociation inhibitor activity 4/2613 17/18639 0.235294117647059 1.678395353549 0.207160086965136 0.585714954401428 GO:0032183 SUMO binding 4/2613 17/18639 0.235294117647059 1.678395353549 0.207160086965136 0.585714954401428 GO:0008235 metalloexopeptidase activity 12/2613 66/18639 0.181818181818182 1.29694186410604 0.207715384405501 0.58597114034751 GO:0017080 sodium channel regulator activity 8/2613 41/18639 0.195121951219512 1.39184004928453 0.208792570699591 0.58769515993791 GO:0052689 carboxylic ester hydrolase activity 16/2613 92/18639 0.173913043478261 1.24055308740578 0.212511644080332 0.595841006733375 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 11/2613 60/18639 0.183333333333333 1.30774971297359 0.212969292362114 0.595841006733375 GO:0051861 glycolipid binding 6/2613 29/18639 0.206896551724138 1.47583039708619 0.213104118982357 0.595841006733375 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 10/2613 54/18639 0.185185185185185 1.32095930603393 0.218247831129103 0.607333133445623 GO:0140463 chromatin-protein adaptor activity 10/2613 54/18639 0.185185185185185 1.32095930603393 0.218247831129103 0.607333133445623 GO:0050660 flavin adenine dinucleotide binding 15/2613 86/18639 0.174418604651163 1.2441593463808 0.218659193167575 0.607333133445623 GO:0016879 ligase activity, forming carbon-nitrogen bonds 9/2613 48/18639 0.1875 1.33747129735936 0.22347794070961 0.619353149966633 GO:0051879 Hsp90 protein binding 8/2613 42/18639 0.19047619047619 1.35870100049205 0.228537661411676 0.620833075653475 GO:0019905 syntaxin binding 11/2613 61/18639 0.180327868852459 1.28631119308878 0.229249109440568 0.620833075653475 GO:0000995 RNA polymerase III general transcription initiation factor activity 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0003720 telomerase activity 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0004526 ribonuclease P activity 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0016208 AMP binding 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0016801 hydrolase activity, acting on ether bonds 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0016803 ether hydrolase activity 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0035197 siRNA binding 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0035251 UDP-glucosyltransferase activity 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0043047 single-stranded telomeric DNA binding 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2613 12/18639 0.25 1.78329506314581 0.230904609422268 0.620833075653475 GO:0035064 methylated histone binding 13/2613 74/18639 0.175675675675676 1.25312626058895 0.231743007724334 0.621761559022095 GO:0015215 nucleotide transmembrane transporter activity 6/2613 30/18639 0.2 1.42663605051665 0.237135376951564 0.629698146234409 GO:0031210 phosphatidylcholine binding 6/2613 30/18639 0.2 1.42663605051665 0.237135376951564 0.629698146234409 GO:0051721 protein phosphatase 2A binding 6/2613 30/18639 0.2 1.42663605051665 0.237135376951564 0.629698146234409 GO:0008308 voltage-gated monoatomic anion channel activity 4/2613 18/18639 0.222222222222222 1.58515116724072 0.238864023523488 0.629698146234409 GO:0015172 acidic amino acid transmembrane transporter activity 4/2613 18/18639 0.222222222222222 1.58515116724072 0.238864023523488 0.629698146234409 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/2613 18/18639 0.222222222222222 1.58515116724072 0.238864023523488 0.629698146234409 GO:0070064 proline-rich region binding 4/2613 18/18639 0.222222222222222 1.58515116724072 0.238864023523488 0.629698146234409 GO:0005540 hyaluronic acid binding 5/2613 24/18639 0.208333333333333 1.48607921928817 0.239553327195921 0.629698146234409 GO:0060229 lipase activator activity 5/2613 24/18639 0.208333333333333 1.48607921928817 0.239553327195921 0.629698146234409 GO:0042826 histone deacetylase binding 21/2613 127/18639 0.165354330708661 1.17950224649014 0.239694774141567 0.629698146234409 GO:0005310 dicarboxylic acid transmembrane transporter activity 6/2613 31/18639 0.193548387096774 1.38061553275805 0.261932938777986 0.686689055715261 GO:0140034 methylation-dependent protein binding 13/2613 76/18639 0.171052631578947 1.22014925373134 0.262517938796325 0.686794856477521 GO:0019838 growth factor binding 22/2613 136/18639 0.161764705882353 1.15389680556494 0.266993698347288 0.687671099618289 GO:0002161 aminoacyl-tRNA editing activity 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0003964 RNA-directed DNA polymerase activity 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0019104 DNA N-glycosylase activity 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0045159 myosin II binding 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0046975 histone H3K36 methyltransferase activity 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0051011 microtubule minus-end binding 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0061459 L-arginine transmembrane transporter activity 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0097157 pre-mRNA intronic binding 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0140410 monoatomic cation:bicarbonate symporter activity 3/2613 13/18639 0.230769230769231 1.6461185198269 0.271066947110252 0.687671099618289 GO:0005346 purine ribonucleotide transmembrane transporter activity 4/2613 19/18639 0.210526315789474 1.50172215843858 0.271578277248143 0.687671099618289 GO:0031420 alkali metal ion binding 4/2613 19/18639 0.210526315789474 1.50172215843858 0.271578277248143 0.687671099618289 GO:0042800 histone H3K4 methyltransferase activity 4/2613 19/18639 0.210526315789474 1.50172215843858 0.271578277248143 0.687671099618289 GO:0046624 sphingolipid transporter activity 4/2613 19/18639 0.210526315789474 1.50172215843858 0.271578277248143 0.687671099618289 GO:0042887 amide transmembrane transporter activity 7/2613 38/18639 0.184210526315789 1.31400688863375 0.278463700809096 0.703692839118778 GO:0050681 nuclear androgen receptor binding 5/2613 26/18639 0.192307692307692 1.37176543318908 0.29635030621186 0.745903664936439 GO:0050750 low-density lipoprotein particle receptor binding 5/2613 26/18639 0.192307692307692 1.37176543318908 0.29635030621186 0.745903664936439 GO:0016004 phospholipase activator activity 4/2613 20/18639 0.2 1.42663605051665 0.304983118854358 0.761551906683851 GO:0030742 GTP-dependent protein binding 4/2613 20/18639 0.2 1.42663605051665 0.304983118854358 0.761551906683851 GO:0031418 L-ascorbic acid binding 4/2613 20/18639 0.2 1.42663605051665 0.304983118854358 0.761551906683851 GO:0140939 histone H4 methyltransferase activity 4/2613 20/18639 0.2 1.42663605051665 0.304983118854358 0.761551906683851 GO:0005313 L-glutamate transmembrane transporter activity 3/2613 14/18639 0.214285714285714 1.52853862555355 0.311880472706632 0.769630677266268 GO:0005347 ATP transmembrane transporter activity 3/2613 14/18639 0.214285714285714 1.52853862555355 0.311880472706632 0.769630677266268 GO:0008494 translation activator activity 3/2613 14/18639 0.214285714285714 1.52853862555355 0.311880472706632 0.769630677266268 GO:0019992 diacylglycerol binding 3/2613 14/18639 0.214285714285714 1.52853862555355 0.311880472706632 0.769630677266268 GO:0046030 inositol trisphosphate phosphatase activity 3/2613 14/18639 0.214285714285714 1.52853862555355 0.311880472706632 0.769630677266268 GO:0098847 sequence-specific single stranded DNA binding 3/2613 14/18639 0.214285714285714 1.52853862555355 0.311880472706632 0.769630677266268 GO:0051213 dioxygenase activity 15/2613 93/18639 0.161290322580645 1.15051294396504 0.320493784014014 0.78934113601889 GO:0004521 RNA endonuclease activity 12/2613 73/18639 0.164383561643836 1.17257757576711 0.322683298153376 0.790905129486514 GO:0004519 endonuclease activity 20/2613 127/18639 0.15748031496063 1.12333547284775 0.323010421638029 0.790905129486514 GO:0019783 ubiquitin-like protein peptidase activity 20/2613 127/18639 0.15748031496063 1.12333547284775 0.323010421638029 0.790905129486514 GO:0004364 glutathione transferase activity 5/2613 27/18639 0.185185185185185 1.32095930603393 0.325547249431767 0.794276894285385 GO:0032451 demethylase activity 7/2613 40/18639 0.175 1.24830654420207 0.325647227871169 0.794276894285385 GO:0048306 calcium-dependent protein binding 13/2613 80/18639 0.1625 1.15914179104478 0.327755862642235 0.797876723536405 GO:0043495 protein-membrane adaptor activity 8/2613 47/18639 0.170212765957447 1.21415834086523 0.335135869249016 0.811286255524381 GO:0061733 protein-lysine-acetyltransferase activity 8/2613 47/18639 0.170212765957447 1.21415834086523 0.335135869249016 0.811286255524381 GO:0042054 histone methyltransferase activity 11/2613 67/18639 0.164179104477612 1.1711191459465 0.33519440057748 0.811286255524381 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/2613 21/18639 0.19047619047619 1.35870100049205 0.338776019472354 0.814336611889065 GO:0019200 carbohydrate kinase activity 4/2613 21/18639 0.19047619047619 1.35870100049205 0.338776019472354 0.814336611889065 GO:1904047 S-adenosyl-L-methionine binding 4/2613 21/18639 0.19047619047619 1.35870100049205 0.338776019472354 0.814336611889065 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 6/2613 34/18639 0.176470588235294 1.25879651516175 0.339525943360215 0.814336611889065 GO:0042578 phosphoric ester hydrolase activity 54/2613 363/18639 0.148760330578512 1.0611342524504 0.339683630335962 0.814336611889065 GO:0015485 cholesterol binding 9/2613 54/18639 0.166666666666667 1.18886337543054 0.34265338059113 0.819897367979915 GO:0042169 SH2 domain binding 7/2613 41/18639 0.170731707317073 1.21786004312397 0.349705539641789 0.82390856515315 GO:0004129 cytochrome-c oxidase activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0008242 omega peptidase activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0016846 carbon-sulfur lyase activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0031386 protein tag activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0042809 nuclear vitamin D receptor binding 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0045504 dynein heavy chain binding 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0050780 dopamine receptor binding 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0061578 K63-linked deubiquitinase activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0140161 monocarboxylate:sodium symporter activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0141047 molecular tag activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0141050 histone H3K deacetylase activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0141051 histone H4K deacetylase activity 3/2613 15/18639 0.2 1.42663605051665 0.352823652008486 0.82390856515315 GO:0032934 sterol binding 11/2613 68/18639 0.161764705882353 1.15389680556494 0.353813497843764 0.824692829539715 GO:0015171 amino acid transmembrane transporter activity 16/2613 102/18639 0.156862745098039 1.11893023569933 0.354557321804775 0.824901813276423 GO:0010485 histone H4 acetyltransferase activity 6/2613 35/18639 0.171428571428571 1.22283090044284 0.365997974326141 0.845281035943707 GO:0034061 DNA polymerase activity 6/2613 35/18639 0.171428571428571 1.22283090044284 0.365997974326141 0.845281035943707 GO:0043015 gamma-tubulin binding 6/2613 35/18639 0.171428571428571 1.22283090044284 0.365997974326141 0.845281035943707 GO:0140566 histone reader activity 6/2613 35/18639 0.171428571428571 1.22283090044284 0.365997974326141 0.845281035943707 GO:0031267 small GTPase binding 42/2613 283/18639 0.148409893992933 1.05863452511836 0.369550319564055 0.849809817003563 GO:0004407 histone deacetylase activity 4/2613 22/18639 0.181818181818182 1.29694186410604 0.372676311501166 0.849809817003563 GO:0008093 cytoskeletal anchor activity 4/2613 22/18639 0.181818181818182 1.29694186410604 0.372676311501166 0.849809817003563 GO:0031683 G-protein beta/gamma-subunit complex binding 4/2613 22/18639 0.181818181818182 1.29694186410604 0.372676311501166 0.849809817003563 GO:0033558 protein lysine deacetylase activity 4/2613 22/18639 0.181818181818182 1.29694186410604 0.372676311501166 0.849809817003563 GO:0061133 endopeptidase activator activity 4/2613 22/18639 0.181818181818182 1.29694186410604 0.372676311501166 0.849809817003563 GO:0140784 metal ion sensor activity 4/2613 22/18639 0.181818181818182 1.29694186410604 0.372676311501166 0.849809817003563 GO:0004402 histone acetyltransferase activity 7/2613 42/18639 0.166666666666667 1.18886337543054 0.373939115287811 0.851150224508898 GO:0017022 myosin binding 12/2613 76/18639 0.157894736842105 1.12629161882893 0.37597732212229 0.854247573326499 GO:0001222 transcription corepressor binding 8/2613 49/18639 0.163265306122449 1.16460085756461 0.379948370844676 0.861717438192691 GO:0043236 laminin binding 5/2613 29/18639 0.172413793103448 1.22985866423849 0.384584836316306 0.870666927459357 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/2613 36/18639 0.166666666666667 1.18886337543054 0.39255419481218 0.882801389523808 GO:0005159 insulin-like growth factor receptor binding 3/2613 16/18639 0.1875 1.33747129735936 0.393445187083569 0.882801389523808 GO:0008296 3'-5'-DNA exonuclease activity 3/2613 16/18639 0.1875 1.33747129735936 0.393445187083569 0.882801389523808 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/2613 16/18639 0.1875 1.33747129735936 0.393445187083569 0.882801389523808 GO:0019841 retinol binding 3/2613 16/18639 0.1875 1.33747129735936 0.393445187083569 0.882801389523808 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 27/2613 181/18639 0.149171270718232 1.06406556254004 0.395167832005129 0.885091716089641 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2613 43/18639 0.162790697674419 1.16121538995541 0.398249790460231 0.888837142956373 GO:0048156 tau protein binding 7/2613 43/18639 0.162790697674419 1.16121538995541 0.398249790460231 0.888837142956373 GO:0004725 protein tyrosine phosphatase activity 15/2613 98/18639 0.153061224489796 1.09181330396682 0.399387748899283 0.889802034208473 GO:0016504 peptidase activator activity 9/2613 57/18639 0.157894736842105 1.12629161882893 0.405771227283827 0.894397630680757 GO:0000295 adenine nucleotide transmembrane transporter activity 4/2613 23/18639 0.173913043478261 1.24055308740578 0.406428341325459 0.894397630680757 GO:0005283 amino acid:sodium symporter activity 4/2613 23/18639 0.173913043478261 1.24055308740578 0.406428341325459 0.894397630680757 GO:0042171 lysophosphatidic acid acyltransferase activity 4/2613 23/18639 0.173913043478261 1.24055308740578 0.406428341325459 0.894397630680757 GO:0071617 lysophospholipid acyltransferase activity 4/2613 23/18639 0.173913043478261 1.24055308740578 0.406428341325459 0.894397630680757 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/2613 30/18639 0.166666666666667 1.18886337543054 0.414074728189254 0.894397630680757 GO:0016769 transferase activity, transferring nitrogenous groups 5/2613 30/18639 0.166666666666667 1.18886337543054 0.414074728189254 0.894397630680757 GO:0032452 histone demethylase activity 5/2613 30/18639 0.166666666666667 1.18886337543054 0.414074728189254 0.894397630680757 GO:0043178 alcohol binding 14/2613 92/18639 0.152173913043478 1.08548395148006 0.414519040367331 0.894397630680757 GO:0000149 SNARE binding 16/2613 106/18639 0.150943396226415 1.07670645322011 0.416177657950119 0.894397630680757 GO:0022829 wide pore channel activity 6/2613 37/18639 0.162162162162162 1.15673193285134 0.419071872162534 0.894397630680757 GO:0030551 cyclic nucleotide binding 6/2613 37/18639 0.162162162162162 1.15673193285134 0.419071872162534 0.894397630680757 GO:0000182 rDNA binding 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0004090 carbonyl reductase (NADPH) activity 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0005345 purine nucleobase transmembrane transporter activity 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0015187 glycine transmembrane transporter activity 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0031419 cobalamin binding 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0031996 thioesterase binding 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0043121 neurotrophin binding 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0043295 glutathione binding 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0050308 sugar-phosphatase activity 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0050815 phosphoserine residue binding 2/2613 10/18639 0.2 1.42663605051665 0.419182394712393 0.894397630680757 GO:0120013 lipid transfer activity 10/2613 65/18639 0.153846153846154 1.09741234655127 0.428296425806584 0.910785460300159 GO:0008237 metallopeptidase activity 27/2613 184/18639 0.146739130434783 1.04671666749863 0.430560866974306 0.910785460300159 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/2613 17/18639 0.176470588235294 1.25879651516175 0.433363422823232 0.910785460300159 GO:0008429 phosphatidylethanolamine binding 3/2613 17/18639 0.176470588235294 1.25879651516175 0.433363422823232 0.910785460300159 GO:0017110 nucleoside diphosphate phosphatase activity 3/2613 17/18639 0.176470588235294 1.25879651516175 0.433363422823232 0.910785460300159 GO:0031489 myosin V binding 3/2613 17/18639 0.176470588235294 1.25879651516175 0.433363422823232 0.910785460300159 GO:0046965 nuclear retinoid X receptor binding 3/2613 17/18639 0.176470588235294 1.25879651516175 0.433363422823232 0.910785460300159 GO:0070403 NAD+ binding 3/2613 17/18639 0.176470588235294 1.25879651516175 0.433363422823232 0.910785460300159 GO:1990226 histone methyltransferase binding 3/2613 17/18639 0.176470588235294 1.25879651516175 0.433363422823232 0.910785460300159 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/2613 24/18639 0.166666666666667 1.18886337543054 0.439803344151367 0.918198703600785 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/2613 24/18639 0.166666666666667 1.18886337543054 0.439803344151367 0.918198703600785 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/2613 24/18639 0.166666666666667 1.18886337543054 0.439803344151367 0.918198703600785 GO:0070300 phosphatidic acid binding 4/2613 24/18639 0.166666666666667 1.18886337543054 0.439803344151367 0.918198703600785 GO:0016411 acylglycerol O-acyltransferase activity 5/2613 31/18639 0.161290322580645 1.15051294396504 0.443332764614498 0.920992777889426 GO:0070325 lipoprotein particle receptor binding 5/2613 31/18639 0.161290322580645 1.15051294396504 0.443332764614498 0.920992777889426 GO:0140457 protein demethylase activity 5/2613 31/18639 0.161290322580645 1.15051294396504 0.443332764614498 0.920992777889426 GO:0101005 deubiquitinase activity 17/2613 115/18639 0.147826086956522 1.05447012429491 0.446878852176141 0.926832619398213 GO:0045309 protein phosphorylated amino acid binding 9/2613 59/18639 0.152542372881356 1.08811224191948 0.447982645918555 0.927596250415925 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0005225 volume-sensitive anion channel activity 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0008046 axon guidance receptor activity 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0015205 nucleobase transmembrane transporter activity 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0015217 ADP transmembrane transporter activity 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0019203 carbohydrate phosphatase activity 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0032794 GTPase activating protein binding 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0034056 estrogen response element binding 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0034713 type I transforming growth factor beta receptor binding 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0043522 leucine zipper domain binding 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0048185 activin binding 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0050998 nitric-oxide synthase binding 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:1900750 oligopeptide binding 2/2613 11/18639 0.181818181818182 1.29694186410604 0.469671322084749 0.932627433808763 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 6/2613 39/18639 0.153846153846154 1.09741234655127 0.47153961741029 0.932627433808763 GO:0015106 bicarbonate transmembrane transporter activity 5/2613 32/18639 0.15625 1.11455941446613 0.472217167314493 0.932627433808763 GO:0042910 xenobiotic transmembrane transporter activity 5/2613 32/18639 0.15625 1.11455941446613 0.472217167314493 0.932627433808763 GO:0000900 mRNA regulatory element binding translation repressor activity 3/2613 18/18639 0.166666666666667 1.18886337543054 0.472263302683181 0.932627433808763 GO:0008409 5'-3' exonuclease activity 3/2613 18/18639 0.166666666666667 1.18886337543054 0.472263302683181 0.932627433808763 GO:0016854 racemase and epimerase activity 3/2613 18/18639 0.166666666666667 1.18886337543054 0.472263302683181 0.932627433808763 GO:0035615 clathrin adaptor activity 3/2613 18/18639 0.166666666666667 1.18886337543054 0.472263302683181 0.932627433808763 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 3/2613 18/18639 0.166666666666667 1.18886337543054 0.472263302683181 0.932627433808763 GO:1990381 ubiquitin-specific protease binding 3/2613 18/18639 0.166666666666667 1.18886337543054 0.472263302683181 0.932627433808763 GO:0004709 MAP kinase kinase kinase activity 4/2613 25/18639 0.16 1.14130884041332 0.472600261858683 0.932627433808763 GO:0005537 D-mannose binding 4/2613 25/18639 0.16 1.14130884041332 0.472600261858683 0.932627433808763 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/2613 25/18639 0.16 1.14130884041332 0.472600261858683 0.932627433808763 GO:0019707 protein-cysteine S-acyltransferase activity 4/2613 25/18639 0.16 1.14130884041332 0.472600261858683 0.932627433808763 GO:0015291 secondary active transmembrane transporter activity 41/2613 287/18639 0.142857142857143 1.01902575036903 0.473927096034659 0.93378448140579 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 13/2613 89/18639 0.146067415730337 1.04192520543351 0.482534895326456 0.947782714963646 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 13/2613 89/18639 0.146067415730337 1.04192520543351 0.482534895326456 0.947782714963646 GO:0003777 microtubule motor activity 10/2613 68/18639 0.147058823529412 1.04899709596812 0.48773277380306 0.956502375996359 GO:0005504 fatty acid binding 7/2613 47/18639 0.148936170212766 1.06238854825708 0.49445622284876 0.966681080639204 GO:0140359 ABC-type transporter activity 7/2613 47/18639 0.148936170212766 1.06238854825708 0.49445622284876 0.966681080639204 GO:0030331 nuclear estrogen receptor binding 6/2613 40/18639 0.15 1.06997703788749 0.49728533321131 0.969206808623589 GO:0071949 FAD binding 6/2613 40/18639 0.15 1.06997703788749 0.49728533321131 0.969206808623589 GO:0140793 histone H2AXY142 phosphatase activity 13/2613 90/18639 0.144444444444444 1.03034825870647 0.499627845047135 0.970941223336826 GO:0140311 protein sequestering activity 5/2613 33/18639 0.151515151515152 1.08078488675504 0.500601051032432 0.970941223336826 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/2613 26/18639 0.153846153846154 1.09741234655127 0.504645708339924 0.970941223336826 GO:0008157 protein phosphatase 1 binding 4/2613 26/18639 0.153846153846154 1.09741234655127 0.504645708339924 0.970941223336826 GO:0015216 purine nucleotide transmembrane transporter activity 4/2613 26/18639 0.153846153846154 1.09741234655127 0.504645708339924 0.970941223336826 GO:0051139 metal cation:proton antiporter activity 4/2613 26/18639 0.153846153846154 1.09741234655127 0.504645708339924 0.970941223336826 GO:0097602 cullin family protein binding 4/2613 26/18639 0.153846153846154 1.09741234655127 0.504645708339924 0.970941223336826 GO:0016279 protein-lysine N-methyltransferase activity 10/2613 69/18639 0.144927536231884 1.03379423950482 0.507249470589448 0.970941223336826 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2613 19/18639 0.157894736842105 1.12629161882893 0.50989174495225 0.970941223336826 GO:0016918 retinal binding 3/2613 19/18639 0.157894736842105 1.12629161882893 0.50989174495225 0.970941223336826 GO:0008374 O-acyltransferase activity 8/2613 55/18639 0.145454545454545 1.03755349128483 0.513828101503146 0.970941223336826 GO:0003995 acyl-CoA dehydrogenase activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0004000 adenosine deaminase activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0005078 MAP-kinase scaffold activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0008179 adenylate cyclase binding 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0010853 cyclase activator activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0015132 prostaglandin transmembrane transporter activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0016840 carbon-nitrogen lyase activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0031543 peptidyl-proline dioxygenase activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0097371 MDM2/MDM4 family protein binding 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0097677 STAT family protein binding 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0140900 chloride:bicarbonate antiporter activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:1990817 poly(A) RNA polymerase activity 2/2613 12/18639 0.166666666666667 1.18886337543054 0.517424664617246 0.970941223336826 GO:0016278 lysine N-methyltransferase activity 10/2613 70/18639 0.142857142857143 1.01902575036903 0.526547616105145 0.986592190057337 GO:0052866 phosphatidylinositol phosphate phosphatase activity 5/2613 34/18639 0.147058823529412 1.04899709596812 0.528372621320746 0.988542841966558 GO:0170055 lipid transmembrane transporter activity 8/2613 56/18639 0.142857142857143 1.01902575036903 0.535358836023992 0.995044637620257 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/2613 27/18639 0.148148148148148 1.05676744482715 0.535793266410908 0.995044637620257 GO:0023026 MHC class II protein complex binding 4/2613 27/18639 0.148148148148148 1.05676744482715 0.535793266410908 0.995044637620257 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 4/2613 27/18639 0.148148148148148 1.05676744482715 0.535793266410908 0.995044637620257 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 4/2613 27/18639 0.148148148148148 1.05676744482715 0.535793266410908 0.995044637620257 GO:0010851 cyclase regulator activity 3/2613 20/18639 0.15 1.06997703788749 0.546052090734232 0.999999999999949 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/2613 20/18639 0.15 1.06997703788749 0.546052090734232 0.999999999999949 GO:0048487 beta-tubulin binding 6/2613 42/18639 0.142857142857143 1.01902575036903 0.547358994912464 0.999999999999949 GO:0017124 SH3 domain binding 16/2613 115/18639 0.139130434782609 0.992442469924624 0.554072658543195 0.999999999999949 GO:0005343 organic acid:sodium symporter activity 5/2613 35/18639 0.142857142857143 1.01902575036903 0.555435062486513 0.999999999999949 GO:0016229 steroid dehydrogenase activity 5/2613 35/18639 0.142857142857143 1.01902575036903 0.555435062486513 0.999999999999949 GO:0140030 modification-dependent protein binding 24/2613 173/18639 0.138728323699422 0.989574139086692 0.555715110162153 0.999999999999949 GO:0004843 cysteine-type deubiquitinase activity 15/2613 108/18639 0.138888888888889 0.99071947952545 0.557844483211183 0.999999999999949 GO:0004535 poly(A)-specific ribonuclease activity 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0005172 vascular endothelial growth factor receptor binding 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0005542 folic acid binding 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0008035 high-density lipoprotein particle binding 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0019855 calcium channel inhibitor activity 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0031432 titin binding 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0039706 co-receptor binding 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0070700 BMP receptor binding 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0071714 icosanoid transmembrane transporter activity 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0140333 glycerophospholipid flippase activity 2/2613 13/18639 0.153846153846154 1.09741234655127 0.562216976891245 0.999999999999949 GO:0036408 histone H3K14 acetyltransferase activity 4/2613 28/18639 0.142857142857143 1.01902575036903 0.565922278246616 0.999999999999949 GO:0046966 nuclear thyroid hormone receptor binding 4/2613 28/18639 0.142857142857143 1.01902575036903 0.565922278246616 0.999999999999949 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2613 28/18639 0.142857142857143 1.01902575036903 0.565922278246616 0.999999999999949 GO:0097718 disordered domain specific binding 4/2613 28/18639 0.142857142857143 1.01902575036903 0.565922278246616 0.999999999999949 GO:0141052 histone H3 demethylase activity 4/2613 28/18639 0.142857142857143 1.01902575036903 0.565922278246616 0.999999999999949 GO:0038024 cargo receptor activity 9/2613 65/18639 0.138461538461538 0.987671111896141 0.57034629852643 0.999999999999949 GO:0003730 mRNA 3'-UTR binding 36/2613 262/18639 0.137404580152672 0.980131637759529 0.579367249897965 0.999999999999949 GO:0001846 opsonin binding 3/2613 21/18639 0.142857142857143 1.01902575036903 0.580598102611211 0.999999999999949 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2613 21/18639 0.142857142857143 1.01902575036903 0.580598102611211 0.999999999999949 GO:0010314 phosphatidylinositol-5-phosphate binding 3/2613 21/18639 0.142857142857143 1.01902575036903 0.580598102611211 0.999999999999949 GO:0015174 basic amino acid transmembrane transporter activity 3/2613 21/18639 0.142857142857143 1.01902575036903 0.580598102611211 0.999999999999949 GO:0061891 calcium ion sensor activity 3/2613 21/18639 0.142857142857143 1.01902575036903 0.580598102611211 0.999999999999949 GO:0140312 cargo adaptor activity 3/2613 21/18639 0.142857142857143 1.01902575036903 0.580598102611211 0.999999999999949 GO:0004033 aldo-keto reductase (NADPH) activity 5/2613 36/18639 0.138888888888889 0.99071947952545 0.581706170175921 0.999999999999949 GO:0005484 SNAP receptor activity 5/2613 36/18639 0.138888888888889 0.99071947952545 0.581706170175921 0.999999999999949 GO:0016409 palmitoyltransferase activity 5/2613 36/18639 0.138888888888889 0.99071947952545 0.581706170175921 0.999999999999949 GO:0016597 amino acid binding 7/2613 51/18639 0.137254901960784 0.979063956236915 0.585347098998623 0.999999999999949 GO:0005416 amino acid:monoatomic cation symporter activity 4/2613 29/18639 0.137931034482759 0.983886931390791 0.594936268955466 0.999999999999949 GO:0010484 histone H3 acetyltransferase activity 4/2613 29/18639 0.137931034482759 0.983886931390791 0.594936268955466 0.999999999999949 GO:0001223 transcription coactivator binding 6/2613 44/18639 0.136363636363636 0.972706398079532 0.595064460208659 0.999999999999949 GO:0043014 alpha-tubulin binding 6/2613 44/18639 0.136363636363636 0.972706398079532 0.595064460208659 0.999999999999949 GO:0004705 JUN kinase activity 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0005161 platelet-derived growth factor receptor binding 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0008392 arachidonate epoxygenase activity 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0008559 ABC-type xenobiotic transporter activity 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0015926 glucosidase activity 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0032036 myosin heavy chain binding 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0032454 histone H3K9 demethylase activity 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0034236 protein kinase A catalytic subunit binding 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0042813 Wnt receptor activity 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0071933 Arp2/3 complex binding 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:1901474 azole transmembrane transporter activity 2/2613 14/18639 0.142857142857143 1.01902575036903 0.60393972758868 0.999999999999949 GO:0030159 signaling receptor complex adaptor activity 7/2613 52/18639 0.134615384615385 0.960235803232359 0.606786389542705 0.999999999999949 GO:0019213 deacetylase activity 5/2613 37/18639 0.135135135135135 0.963943277376113 0.607117779240513 0.999999999999949 GO:0050840 extracellular matrix binding 9/2613 67/18639 0.134328358208955 0.958188392138047 0.608498507432208 0.999999999999949 GO:0015377 chloride:monoatomic cation symporter activity 3/2613 22/18639 0.136363636363636 0.972706398079532 0.61342785910227 0.999999999999949 GO:0043995 histone H4K5 acetyltransferase activity 4/2613 30/18639 0.133333333333333 0.951090700344432 0.622761121381037 0.999999999999949 GO:0043996 histone H4K8 acetyltransferase activity 4/2613 30/18639 0.133333333333333 0.951090700344432 0.622761121381037 0.999999999999949 GO:0043997 histone H4K12 acetyltransferase activity 4/2613 30/18639 0.133333333333333 0.951090700344432 0.622761121381037 0.999999999999949 GO:0070566 adenylyltransferase activity 4/2613 30/18639 0.133333333333333 0.951090700344432 0.622761121381037 0.999999999999949 GO:0030165 PDZ domain binding 11/2613 83/18639 0.132530120481928 0.945361238294164 0.627754713853976 0.999999999999949 GO:0030276 clathrin binding 6/2613 46/18639 0.130434782608696 0.930414815554335 0.639958644385853 0.999999999999949 GO:0002020 protease binding 18/2613 136/18639 0.132352941176471 0.944097386371311 0.641553946589857 0.999999999999949 GO:0004089 carbonate dehydratase activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0004559 alpha-mannosidase activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0005041 low-density lipoprotein particle receptor activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0005523 tropomyosin binding 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0010181 FMN binding 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0015116 sulfate transmembrane transporter activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0017081 chloride channel regulator activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0034483 heparan sulfate sulfotransferase activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0048531 beta-1,3-galactosyltransferase activity 2/2613 15/18639 0.133333333333333 0.951090700344432 0.642572969985633 0.999999999999949 GO:0003887 DNA-directed DNA polymerase activity 3/2613 23/18639 0.130434782608696 0.930414815554335 0.644477786768792 0.999999999999949 GO:0043274 phospholipase binding 3/2613 23/18639 0.130434782608696 0.930414815554335 0.644477786768792 0.999999999999949 GO:0047499 calcium-independent phospholipase A2 activity 4/2613 31/18639 0.129032258064516 0.920410355172031 0.649343100161265 0.999999999999949 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2613 31/18639 0.129032258064516 0.920410355172031 0.649343100161265 0.999999999999949 GO:0001784 phosphotyrosine residue binding 6/2613 47/18639 0.127659574468085 0.910618755648924 0.661251681683964 0.999999999999949 GO:0016782 transferase activity, transferring sulphur-containing groups 9/2613 70/18639 0.128571428571429 0.917123175332131 0.662328592353874 0.999999999999949 GO:0016247 channel regulator activity 22/2613 168/18639 0.130952380952381 0.934106937838281 0.668856822206606 0.999999999999949 GO:0015295 solute:proton symporter activity 3/2613 24/18639 0.125 0.891647531572905 0.673716992856995 0.999999999999949 GO:0030215 semaphorin receptor binding 3/2613 24/18639 0.125 0.891647531572905 0.673716992856995 0.999999999999949 GO:0030552 cAMP binding 3/2613 24/18639 0.125 0.891647531572905 0.673716992856995 0.999999999999949 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/2613 24/18639 0.125 0.891647531572905 0.673716992856995 0.999999999999949 GO:0070840 dynein complex binding 3/2613 24/18639 0.125 0.891647531572905 0.673716992856995 0.999999999999949 GO:0008378 galactosyltransferase activity 4/2613 32/18639 0.125 0.891647531572905 0.67464680485366 0.999999999999949 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/2613 32/18639 0.125 0.891647531572905 0.67464680485366 0.999999999999949 GO:0043425 bHLH transcription factor binding 4/2613 32/18639 0.125 0.891647531572905 0.67464680485366 0.999999999999949 GO:0047498 calcium-dependent phospholipase A2 activity 4/2613 32/18639 0.125 0.891647531572905 0.67464680485366 0.999999999999949 GO:0120015 sterol transfer activity 4/2613 32/18639 0.125 0.891647531572905 0.67464680485366 0.999999999999949 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0004707 MAP kinase activity 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0005149 interleukin-1 receptor binding 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0008391 arachidonate monooxygenase activity 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0015378 sodium:chloride symporter activity 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0015385 sodium:proton antiporter activity 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0015562 efflux transmembrane transporter activity 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0015923 mannosidase activity 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0016722 oxidoreductase activity, acting on metal ions 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0140327 flippase activity 2/2613 16/18639 0.125 0.891647531572905 0.678162653257356 0.999999999999949 GO:0032266 phosphatidylinositol-3-phosphate binding 6/2613 48/18639 0.125 0.891647531572905 0.68173841491393 0.999999999999949 GO:0046982 protein heterodimerization activity 49/2613 369/18639 0.132791327913279 0.947224477985308 0.682864823234294 0.999999999999949 GO:0008238 exopeptidase activity 13/2613 102/18639 0.127450980392157 0.909130816505707 0.687483174952199 0.999999999999949 GO:0141108 transporter regulator activity 22/2613 170/18639 0.129411764705882 0.923117444451949 0.690749998024923 0.999999999999949 GO:0004536 DNA nuclease activity 8/2613 64/18639 0.125 0.891647531572905 0.690924052585332 0.999999999999949 GO:0005518 collagen binding 9/2613 72/18639 0.125 0.891647531572905 0.69569438205008 0.999999999999949 GO:1901681 sulfur compound binding 36/2613 275/18639 0.130909090909091 0.933798142156351 0.698214043611486 0.999999999999949 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/2613 41/18639 0.121951219512195 0.869900030802834 0.699253378961445 0.999999999999949 GO:0000030 mannosyltransferase activity 3/2613 25/18639 0.12 0.855981630309988 0.701142001629493 0.999999999999949 GO:0008483 transaminase activity 3/2613 25/18639 0.12 0.855981630309988 0.701142001629493 0.999999999999949 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/2613 25/18639 0.12 0.855981630309988 0.701142001629493 0.999999999999949 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/2613 25/18639 0.12 0.855981630309988 0.701142001629493 0.999999999999949 GO:0042974 nuclear retinoic acid receptor binding 3/2613 25/18639 0.12 0.855981630309988 0.701142001629493 0.999999999999949 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2613 17/18639 0.117647058823529 0.839197676774499 0.710802550648573 0.999999999999949 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/2613 17/18639 0.117647058823529 0.839197676774499 0.710802550648573 0.999999999999949 GO:0016805 dipeptidase activity 2/2613 17/18639 0.117647058823529 0.839197676774499 0.710802550648573 0.999999999999949 GO:0030169 low-density lipoprotein particle binding 2/2613 17/18639 0.117647058823529 0.839197676774499 0.710802550648573 0.999999999999949 GO:0036041 long-chain fatty acid binding 2/2613 17/18639 0.117647058823529 0.839197676774499 0.710802550648573 0.999999999999949 GO:0038191 neuropilin binding 2/2613 17/18639 0.117647058823529 0.839197676774499 0.710802550648573 0.999999999999949 GO:0045125 bioactive lipid receptor activity 2/2613 17/18639 0.117647058823529 0.839197676774499 0.710802550648573 0.999999999999949 GO:0005200 structural constituent of cytoskeleton 14/2613 112/18639 0.125 0.891647531572905 0.718893163971643 0.999999999999949 GO:0004520 DNA endonuclease activity 5/2613 42/18639 0.119047619047619 0.849188125307528 0.719779647076172 0.999999999999949 GO:0008307 structural constituent of muscle 5/2613 42/18639 0.119047619047619 0.849188125307528 0.719779647076172 0.999999999999949 GO:0008376 acetylgalactosaminyltransferase activity 4/2613 34/18639 0.117647058823529 0.839197676774499 0.721357181646195 0.999999999999949 GO:0004529 DNA exonuclease activity 3/2613 26/18639 0.115384615384615 0.823059259913451 0.726771952928132 0.999999999999949 GO:0008198 ferrous iron binding 3/2613 26/18639 0.115384615384615 0.823059259913451 0.726771952928132 0.999999999999949 GO:0034237 protein kinase A regulatory subunit binding 3/2613 26/18639 0.115384615384615 0.823059259913451 0.726771952928132 0.999999999999949 GO:0052742 phosphatidylinositol kinase activity 3/2613 26/18639 0.115384615384615 0.823059259913451 0.726771952928132 0.999999999999949 GO:0070412 R-SMAD binding 3/2613 26/18639 0.115384615384615 0.823059259913451 0.726771952928132 0.999999999999949 GO:0070888 E-box binding 7/2613 59/18639 0.11864406779661 0.846309521492926 0.738570007104317 0.999999999999949 GO:0008200 ion channel inhibitor activity 5/2613 43/18639 0.116279069767442 0.829439564253865 0.739285013019785 0.999999999999949 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 8/2613 67/18639 0.119402985074627 0.851723015233819 0.739834925953596 0.999999999999949 GO:0008013 beta-catenin binding 13/2613 106/18639 0.122641509433962 0.87482399324134 0.739851421695845 0.999999999999949 GO:0004706 JUN kinase kinase kinase activity 2/2613 18/18639 0.111111111111111 0.79257558362036 0.740619956644247 0.999999999999949 GO:0015373 monoatomic anion:sodium symporter activity 2/2613 18/18639 0.111111111111111 0.79257558362036 0.740619956644247 0.999999999999949 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/2613 18/18639 0.111111111111111 0.79257558362036 0.740619956644247 0.999999999999949 GO:0017075 syntaxin-1 binding 2/2613 18/18639 0.111111111111111 0.79257558362036 0.740619956644247 0.999999999999949 GO:0030228 lipoprotein particle receptor activity 2/2613 18/18639 0.111111111111111 0.79257558362036 0.740619956644247 0.999999999999949 GO:0031690 adrenergic receptor binding 2/2613 18/18639 0.111111111111111 0.79257558362036 0.740619956644247 0.999999999999949 GO:0050811 GABA receptor binding 2/2613 18/18639 0.111111111111111 0.79257558362036 0.740619956644247 0.999999999999949 GO:0004623 phospholipase A2 activity 4/2613 35/18639 0.114285714285714 0.815220600295227 0.742766487344219 0.999999999999949 GO:0099106 ion channel regulator activity 20/2613 160/18639 0.125 0.891647531572905 0.74376098884523 0.999999999999949 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/2613 27/18639 0.111111111111111 0.79257558362036 0.750644288742785 0.999999999999949 GO:0005080 protein kinase C binding 6/2613 52/18639 0.115384615384615 0.823059259913451 0.755352188258687 0.999999999999949 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/2613 52/18639 0.115384615384615 0.823059259913451 0.755352188258687 0.999999999999949 GO:0016248 channel inhibitor activity 5/2613 44/18639 0.113636363636364 0.810588665066277 0.757774827482749 0.999999999999949 GO:0004190 aspartic-type endopeptidase activity 4/2613 36/18639 0.111111111111111 0.79257558362036 0.762899026990256 0.999999999999949 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/2613 36/18639 0.111111111111111 0.79257558362036 0.762899026990256 0.999999999999949 GO:0015294 solute:monoatomic cation symporter activity 14/2613 116/18639 0.120689655172414 0.860901064966943 0.766194946382472 0.999999999999949 GO:0070003 threonine-type peptidase activity 2/2613 19/18639 0.105263157894737 0.750861079219288 0.767764452137423 0.999999999999949 GO:0120227 acyl-CoA binding 2/2613 19/18639 0.105263157894737 0.750861079219288 0.767764452137423 0.999999999999949 GO:1990380 K48-linked deubiquitinase activity 2/2613 19/18639 0.105263157894737 0.750861079219288 0.767764452137423 0.999999999999949 GO:0005246 calcium channel regulator activity 6/2613 53/18639 0.113207547169811 0.807529839915084 0.771657898130135 0.999999999999949 GO:0017046 peptide hormone binding 6/2613 53/18639 0.113207547169811 0.807529839915084 0.771657898130135 0.999999999999949 GO:0045499 chemorepellent activity 3/2613 28/18639 0.107142857142857 0.764269312776775 0.772810930002325 0.999999999999949 GO:0050698 proteoglycan sulfotransferase activity 3/2613 28/18639 0.107142857142857 0.764269312776775 0.772810930002325 0.999999999999949 GO:0051393 alpha-actinin binding 3/2613 28/18639 0.107142857142857 0.764269312776775 0.772810930002325 0.999999999999949 GO:0141110 transporter inhibitor activity 5/2613 45/18639 0.111111111111111 0.79257558362036 0.775261051209631 0.999999999999949 GO:0004382 GDP phosphatase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0004955 prostaglandin receptor activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0005381 iron ion transmembrane transporter activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0008140 cAMP response element binding protein binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0008239 dipeptidyl-peptidase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0008401 retinoic acid 4-hydroxylase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0015643 toxic substance binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0019531 oxalate transmembrane transporter activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0019911 structural constituent of myelin sheath 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0032052 bile acid binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0035374 chondroitin sulfate binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0042975 peroxisome proliferator activated receptor binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0043208 glycosphingolipid binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0043422 protein kinase B binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0045322 unmethylated CpG binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0051864 histone H3K36 demethylase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0070097 delta-catenin binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0099122 RNA polymerase II C-terminal domain binding 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0140135 mechanosensitive monoatomic cation channel activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0140999 histone H3K4 trimethyltransferase activity 1/2613 10/18639 0.1 0.713318025258324 0.779273599926647 0.999999999999949 GO:0008234 cysteine-type peptidase activity 23/2613 187/18639 0.122994652406417 0.877343025718794 0.781441052528491 0.999999999999949 GO:0031406 carboxylic acid binding 23/2613 187/18639 0.122994652406417 0.877343025718794 0.781441052528491 0.999999999999949 GO:0023023 MHC protein complex binding 4/2613 37/18639 0.108108108108108 0.771154621900891 0.781781602475073 0.999999999999949 GO:0070001 aspartic-type peptidase activity 4/2613 37/18639 0.108108108108108 0.771154621900891 0.781781602475073 0.999999999999949 GO:0042562 hormone binding 11/2613 94/18639 0.117021276595745 0.834733859344847 0.783666504650234 0.999999999999949 GO:0004222 metalloendopeptidase activity 13/2613 110/18639 0.118181818181818 0.843012211668928 0.786123762071574 0.999999999999949 GO:0005326 neurotransmitter transmembrane transporter activity 2/2613 20/18639 0.1 0.713318025258324 0.79239915896 0.999999999999949 GO:0042288 MHC class I protein binding 2/2613 20/18639 0.1 0.713318025258324 0.79239915896 0.999999999999949 GO:0140664 ATP-dependent DNA damage sensor activity 2/2613 20/18639 0.1 0.713318025258324 0.79239915896 0.999999999999949 GO:0003785 actin monomer binding 3/2613 29/18639 0.103448275862069 0.737915198543094 0.793334929353886 0.999999999999949 GO:0035250 UDP-galactosyltransferase activity 3/2613 29/18639 0.103448275862069 0.737915198543094 0.793334929353886 0.999999999999949 GO:0033293 monocarboxylic acid binding 9/2613 79/18639 0.113924050632911 0.812640788268976 0.795262391237915 0.999999999999949 GO:0043177 organic acid binding 23/2613 189/18639 0.121693121693122 0.868058972536584 0.797978067240501 0.999999999999949 GO:0000146 microfilament motor activity 4/2613 38/18639 0.105263157894737 0.750861079219288 0.799448257705 0.999999999999949 GO:0005109 frizzled binding 4/2613 38/18639 0.105263157894737 0.750861079219288 0.799448257705 0.999999999999949 GO:0005501 retinoid binding 4/2613 38/18639 0.105263157894737 0.750861079219288 0.799448257705 0.999999999999949 GO:0019840 isoprenoid binding 4/2613 38/18639 0.105263157894737 0.750861079219288 0.799448257705 0.999999999999949 GO:0004197 cysteine-type endopeptidase activity 10/2613 88/18639 0.113636363636364 0.810588665066277 0.806445961448512 0.999999999999949 GO:0016757 glycosyltransferase activity 33/2613 267/18639 0.123595505617978 0.881629019982198 0.808077255307216 0.999999999999949 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0003953 NAD+ nucleosidase activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0004016 adenylate cyclase activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0004954 prostanoid receptor activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0008172 S-methyltransferase activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0008199 ferric iron binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0016594 glycine binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0031731 CCR6 chemokine receptor binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0032050 clathrin heavy chain binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0032404 mismatch repair complex binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0042608 T cell receptor binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0050786 RAGE receptor binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0070697 activin receptor binding 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0097493 structural molecule activity conferring elasticity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0140537 transcription regulator activator activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0180030 inositol phosphate kinase activity 1/2613 11/18639 0.0909090909090909 0.648470932053022 0.810233827710837 0.999999999999949 GO:0031624 ubiquitin conjugating enzyme binding 3/2613 30/18639 0.1 0.713318025258324 0.812287574684202 0.999999999999949 GO:0033612 receptor serine/threonine kinase binding 3/2613 30/18639 0.1 0.713318025258324 0.812287574684202 0.999999999999949 GO:0098918 structural constituent of synapse 3/2613 30/18639 0.1 0.713318025258324 0.812287574684202 0.999999999999949 GO:0005123 death receptor binding 2/2613 21/18639 0.0952380952380952 0.679350500246023 0.814694006996714 0.999999999999949 GO:0009975 cyclase activity 2/2613 21/18639 0.0952380952380952 0.679350500246023 0.814694006996714 0.999999999999949 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/2613 21/18639 0.0952380952380952 0.679350500246023 0.814694006996714 0.999999999999949 GO:0051428 peptide hormone receptor binding 2/2613 21/18639 0.0952380952380952 0.679350500246023 0.814694006996714 0.999999999999949 GO:0000217 DNA secondary structure binding 4/2613 39/18639 0.102564102564103 0.731608231034178 0.815938854549418 0.999999999999949 GO:0005516 calmodulin binding 25/2613 207/18639 0.120772946859903 0.861495199587348 0.817573552555934 0.999999999999949 GO:0035591 signaling adaptor activity 15/2613 129/18639 0.116279069767442 0.829439564253865 0.818000396725384 0.999999999999949 GO:0106310 protein serine kinase activity 45/2613 361/18639 0.124653739612188 0.889177593812315 0.82464421557542 0.999999999999949 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 15/2613 130/18639 0.115384615384615 0.823059259913451 0.826862298728726 0.999999999999949 GO:0035402 histone H3T11 kinase activity 30/2613 247/18639 0.121457489878543 0.866378168329948 0.827440590070175 0.999999999999949 GO:0005452 solute:inorganic anion antiporter activity 3/2613 31/18639 0.0967741935483871 0.690307766379023 0.829745911240231 0.999999999999949 GO:0003684 damaged DNA binding 8/2613 74/18639 0.108108108108108 0.771154621900891 0.832253948451274 0.999999999999949 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0032931 histone H3K56 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0043992 histone H3K9 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0043993 histone H3K18 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0043994 histone H3K23 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0043999 histone H2AK5 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0044012 histone H2AK9 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0044014 histone H2BK5 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0044015 histone H2BK12 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0044016 histone H3K4 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0044017 histone H3K27 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0044018 histone H3K36 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0046972 histone H4K16 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0140035 ubiquitin-like protein reader activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0140908 histone H3K122 acetyltransferase activity 2/2613 22/18639 0.0909090909090909 0.648470932053022 0.834820621786159 0.999999999999949 GO:0035401 histone H3Y41 kinase activity 13/2613 115/18639 0.11304347826087 0.806359506813757 0.835347174737102 0.999999999999949 GO:0140801 histone H2AXY142 kinase activity 13/2613 115/18639 0.11304347826087 0.806359506813757 0.835347174737102 0.999999999999949 GO:0030295 protein kinase activator activity 16/2613 139/18639 0.115107913669065 0.821085496700229 0.835790444488817 0.999999999999949 GO:0004032 aldose reductase (NADPH) activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0004126 cytidine deaminase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0004300 enoyl-CoA hydratase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0004875 complement receptor activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0005025 transforming growth factor beta receptor activity, type I 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0005026 transforming growth factor beta receptor activity, type II 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0005165 neurotrophin receptor binding 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0005247 voltage-gated chloride channel activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0015368 calcium:monoatomic cation antiporter activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0016361 activin receptor activity, type I 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0016362 activin receptor activity, type II 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0017002 activin receptor activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0035259 nuclear glucocorticoid receptor binding 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0035497 cAMP response element binding 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0045295 gamma-catenin binding 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0070008 serine-type exopeptidase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0070410 co-SMAD binding 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2613 12/18639 0.0833333333333333 0.59443168771527 0.836852842537527 0.999999999999949 GO:0019209 kinase activator activity 17/2613 148/18639 0.114864864864865 0.819351785769696 0.844126445452553 0.999999999999949 GO:0005496 steroid binding 12/2613 108/18639 0.111111111111111 0.79257558362036 0.844803256624815 0.999999999999949 GO:0140828 metal cation:monoatomic cation antiporter activity 4/2613 41/18639 0.0975609756097561 0.695920024642267 0.8455728632074 0.999999999999949 GO:0071813 lipoprotein particle binding 3/2613 32/18639 0.09375 0.668735648679678 0.84579064638367 0.999999999999949 GO:0071814 protein-lipid complex binding 3/2613 32/18639 0.09375 0.668735648679678 0.84579064638367 0.999999999999949 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 29/2613 243/18639 0.119341563786008 0.851284886110757 0.8502826618019 0.999999999999949 GO:0004879 nuclear receptor activity 6/2613 59/18639 0.101694915254237 0.725408161279651 0.852708397180662 0.999999999999949 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/2613 23/18639 0.0869565217391304 0.62027654370289 0.852948510835432 0.999999999999949 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/2613 23/18639 0.0869565217391304 0.62027654370289 0.852948510835432 0.999999999999949 GO:0016493 C-C chemokine receptor activity 2/2613 23/18639 0.0869565217391304 0.62027654370289 0.852948510835432 0.999999999999949 GO:0044013 histone H2B acetyltransferase activity 2/2613 23/18639 0.0869565217391304 0.62027654370289 0.852948510835432 0.999999999999949 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/2613 23/18639 0.0869565217391304 0.62027654370289 0.852948510835432 0.999999999999949 GO:0099186 structural constituent of postsynapse 2/2613 23/18639 0.0869565217391304 0.62027654370289 0.852948510835432 0.999999999999949 GO:0140103 catalytic activity, acting on a glycoprotein 2/2613 23/18639 0.0869565217391304 0.62027654370289 0.852948510835432 0.999999999999949 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/2613 23/18639 0.0869565217391304 0.62027654370289 0.852948510835432 0.999999999999949 GO:0016758 hexosyltransferase activity 23/2613 197/18639 0.116751269035533 0.832807846748297 0.855361506600414 0.999999999999949 GO:0019894 kinesin binding 4/2613 42/18639 0.0952380952380952 0.679350500246023 0.858814254379108 0.999999999999949 GO:0042056 chemoattractant activity 4/2613 42/18639 0.0952380952380952 0.679350500246023 0.858814254379108 0.999999999999949 GO:0008417 fucosyltransferase activity 1/2613 13/18639 0.0769230769230769 0.548706173275634 0.859739164674717 0.999999999999949 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/2613 13/18639 0.0769230769230769 0.548706173275634 0.859739164674717 0.999999999999949 GO:0017154 semaphorin receptor activity 1/2613 13/18639 0.0769230769230769 0.548706173275634 0.859739164674717 0.999999999999949 GO:0035673 oligopeptide transmembrane transporter activity 1/2613 13/18639 0.0769230769230769 0.548706173275634 0.859739164674717 0.999999999999949 GO:0046974 histone H3K9 methyltransferase activity 1/2613 13/18639 0.0769230769230769 0.548706173275634 0.859739164674717 0.999999999999949 GO:0070123 transforming growth factor beta receptor activity, type III 1/2613 13/18639 0.0769230769230769 0.548706173275634 0.859739164674717 0.999999999999949 GO:0071837 HMG box domain binding 1/2613 13/18639 0.0769230769230769 0.548706173275634 0.859739164674717 0.999999999999949 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2613 13/18639 0.0769230769230769 0.548706173275634 0.859739164674717 0.999999999999949 GO:0005030 neurotrophin receptor activity 5/2613 51/18639 0.0980392156862745 0.699331397312082 0.860387647060659 0.999999999999949 GO:0019239 deaminase activity 3/2613 33/18639 0.0909090909090909 0.648470932053022 0.860504399449481 0.999999999999949 GO:0019956 chemokine binding 3/2613 33/18639 0.0909090909090909 0.648470932053022 0.860504399449481 0.999999999999949 GO:0071889 14-3-3 protein binding 3/2613 33/18639 0.0909090909090909 0.648470932053022 0.860504399449481 0.999999999999949 GO:0004676 3-phosphoinositide-dependent protein kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0004711 ribosomal protein S6 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0035175 histone H3S10 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0035979 histone H2AXS139 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0044022 histone H3S28 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0044023 histone H4S1 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0044024 histone H2AS1 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0044025 histone H2BS14 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0072354 histone H3T3 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0072371 histone H2AS121 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0072518 Rho-dependent protein serine/threonine kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0140823 histone H2BS36 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0140855 histone H3S57 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0140995 histone H2A kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0140997 histone H4 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0140998 histone H2B kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:1990244 histone H2AT120 kinase activity 29/2613 245/18639 0.118367346938776 0.844335621734342 0.861661074041789 0.999999999999949 GO:0098531 ligand-modulated transcription factor activity 6/2613 60/18639 0.1 0.713318025258324 0.863610995582106 0.999999999999949 GO:0004677 DNA-dependent protein kinase activity 29/2613 246/18639 0.117886178861789 0.840903363109406 0.867100641039157 0.999999999999949 GO:0140857 histone H3T45 kinase activity 29/2613 246/18639 0.117886178861789 0.840903363109406 0.867100641039157 0.999999999999949 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0004622 lysophospholipase activity 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0005315 phosphate transmembrane transporter activity 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0015149 hexose transmembrane transporter activity 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0019957 C-C chemokine binding 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0043998 histone H2A acetyltransferase activity 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0050431 transforming growth factor beta binding 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0055056 D-glucose transmembrane transporter activity 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:0140612 DNA damage sensor activity 2/2613 24/18639 0.0833333333333333 0.59443168771527 0.869242285197108 0.999999999999949 GO:1902936 phosphatidylinositol bisphosphate binding 12/2613 111/18639 0.108108108108108 0.771154621900891 0.869533562222372 0.999999999999949 GO:0035403 histone H3T6 kinase activity 29/2613 247/18639 0.117408906882591 0.837498896052283 0.872376519379067 0.999999999999949 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/2613 34/18639 0.0882352941176471 0.629398257580874 0.873970259236896 0.999999999999949 GO:0004674 protein serine/threonine kinase activity 53/2613 433/18639 0.122401847575058 0.873114442002105 0.875887386495463 0.999999999999949 GO:0004679 AMP-activated protein kinase activity 29/2613 248/18639 0.116935483870968 0.834121884374653 0.877490929839674 0.999999999999949 GO:1901981 phosphatidylinositol phosphate binding 21/2613 185/18639 0.113513513513514 0.809712352995935 0.878431610123579 0.999999999999949 GO:0004065 arylsulfatase activity 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0005545 1-phosphatidylinositol binding 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0015386 potassium:proton antiporter activity 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0030983 mismatched DNA binding 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0031404 chloride ion binding 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0043176 amine binding 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0098821 BMP receptor activity 1/2613 14/18639 0.0714285714285714 0.509512875184517 0.879416044450566 0.999999999999949 GO:0051018 protein kinase A binding 5/2613 53/18639 0.0943396226415094 0.67294153326257 0.881968270988495 0.999999999999949 GO:0030547 signaling receptor inhibitor activity 4/2613 44/18639 0.0909090909090909 0.648470932053022 0.882403547375949 0.999999999999949 GO:0001848 complement binding 2/2613 25/18639 0.08 0.570654420206659 0.883859701159509 0.999999999999949 GO:0003707 nuclear steroid receptor activity 2/2613 25/18639 0.08 0.570654420206659 0.883859701159509 0.999999999999949 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/2613 25/18639 0.08 0.570654420206659 0.883859701159509 0.999999999999949 GO:0120020 cholesterol transfer activity 2/2613 25/18639 0.08 0.570654420206659 0.883859701159509 0.999999999999949 GO:0015293 symporter activity 16/2613 146/18639 0.10958904109589 0.781718383844738 0.88560044535129 0.999999999999949 GO:0005154 epidermal growth factor receptor binding 3/2613 35/18639 0.0857142857142857 0.61141545022142 0.886270612851835 0.999999999999949 GO:0004715 non-membrane spanning protein tyrosine kinase activity 4/2613 45/18639 0.0888888888888889 0.634060466896288 0.8928564738312 0.999999999999949 GO:0042605 peptide antigen binding 4/2613 45/18639 0.0888888888888889 0.634060466896288 0.8928564738312 0.999999999999949 GO:0004953 icosanoid receptor activity 1/2613 15/18639 0.0666666666666667 0.475545350172216 0.896333406912347 0.999999999999949 GO:0015929 hexosaminidase activity 1/2613 15/18639 0.0666666666666667 0.475545350172216 0.896333406912347 0.999999999999949 GO:0030553 cGMP binding 1/2613 15/18639 0.0666666666666667 0.475545350172216 0.896333406912347 0.999999999999949 GO:0033130 acetylcholine receptor binding 1/2613 15/18639 0.0666666666666667 0.475545350172216 0.896333406912347 0.999999999999949 GO:0030971 receptor tyrosine kinase binding 8/2613 81/18639 0.0987654320987654 0.704511629884764 0.896760763047446 0.999999999999949 GO:0001637 G protein-coupled chemoattractant receptor activity 2/2613 26/18639 0.0769230769230769 0.548706173275634 0.896950346845457 0.999999999999949 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/2613 26/18639 0.0769230769230769 0.548706173275634 0.896950346845457 0.999999999999949 GO:0004950 chemokine receptor activity 2/2613 26/18639 0.0769230769230769 0.548706173275634 0.896950346845457 0.999999999999949 GO:0005112 Notch binding 2/2613 26/18639 0.0769230769230769 0.548706173275634 0.896950346845457 0.999999999999949 GO:0005160 transforming growth factor beta receptor binding 2/2613 26/18639 0.0769230769230769 0.548706173275634 0.896950346845457 0.999999999999949 GO:0005227 calcium-activated cation channel activity 2/2613 26/18639 0.0769230769230769 0.548706173275634 0.896950346845457 0.999999999999949 GO:0015145 monosaccharide transmembrane transporter activity 2/2613 26/18639 0.0769230769230769 0.548706173275634 0.896950346845457 0.999999999999949 GO:0141003 histone H2AX kinase activity 42/2613 354/18639 0.11864406779661 0.846309521492926 0.897586180820822 0.999999999999949 GO:0008509 monoatomic anion transmembrane transporter activity 16/2613 149/18639 0.10738255033557 0.765979087525717 0.902875219731312 0.999999999999949 GO:0042805 actinin binding 3/2613 37/18639 0.0810810810810811 0.578365966425668 0.907695441780475 0.999999999999949 GO:0140996 histone H3 kinase activity 42/2613 357/18639 0.117647058823529 0.839197676774499 0.908312470323028 0.999999999999949 GO:0035255 ionotropic glutamate receptor binding 2/2613 27/18639 0.0740740740740741 0.528383722413573 0.908654831493671 0.999999999999949 GO:0000062 fatty-acyl-CoA binding 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0005024 transforming growth factor beta receptor activity 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0055102 lipase inhibitor activity 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0070411 I-SMAD binding 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/2613 16/18639 0.0625 0.445823765786452 0.91087812382268 0.999999999999949 GO:0004620 phospholipase activity 11/2613 109/18639 0.100917431192661 0.719862227324914 0.91210704361715 0.999999999999949 GO:0035173 histone kinase activity 42/2613 360/18639 0.116666666666667 0.832204362801378 0.918128700392942 0.999999999999949 GO:0019789 SUMO transferase activity 2/2613 28/18639 0.0714285714285714 0.509512875184517 0.91910436237762 0.999999999999949 GO:0046875 ephrin receptor binding 2/2613 28/18639 0.0714285714285714 0.509512875184517 0.91910436237762 0.999999999999949 GO:0051019 mitogen-activated protein kinase binding 2/2613 28/18639 0.0714285714285714 0.509512875184517 0.91910436237762 0.999999999999949 GO:0051119 sugar transmembrane transporter activity 2/2613 28/18639 0.0714285714285714 0.509512875184517 0.91910436237762 0.999999999999949 GO:0016500 protein-hormone receptor activity 6/2613 67/18639 0.0895522388059701 0.638792261425365 0.922532580478213 0.999999999999949 GO:0008484 sulfuric ester hydrolase activity 1/2613 17/18639 0.0588235294117647 0.419598838387249 0.923382847146062 0.999999999999949 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/2613 17/18639 0.0588235294117647 0.419598838387249 0.923382847146062 0.999999999999949 GO:0015278 intracellularly gated calcium channel activity 1/2613 17/18639 0.0588235294117647 0.419598838387249 0.923382847146062 0.999999999999949 GO:0070492 oligosaccharide binding 1/2613 17/18639 0.0588235294117647 0.419598838387249 0.923382847146062 0.999999999999949 GO:1901567 fatty acid derivative binding 1/2613 17/18639 0.0588235294117647 0.419598838387249 0.923382847146062 0.999999999999949 GO:0005004 GPI-linked ephrin receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0005008 hepatocyte growth factor receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0005009 insulin receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0005011 macrophage colony-stimulating factor receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0005018 platelet-derived growth factor alpha-receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0005020 stem cell factor receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0008288 boss receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0036332 placental growth factor receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0038062 protein tyrosine kinase collagen receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0060175 brain-derived neurotrophic factor receptor activity 4/2613 49/18639 0.0816326530612245 0.582300428782305 0.926926034431466 0.999999999999949 GO:0035091 phosphatidylinositol binding 32/2613 284/18639 0.112676056338028 0.803738620009379 0.927319702820159 0.999999999999949 GO:0004181 metallocarboxypeptidase activity 2/2613 29/18639 0.0689655172413793 0.491943465695396 0.928420616675675 0.999999999999949 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/2613 29/18639 0.0689655172413793 0.491943465695396 0.928420616675675 0.999999999999949 GO:0097472 cyclin-dependent protein kinase activity 2/2613 29/18639 0.0689655172413793 0.491943465695396 0.928420616675675 0.999999999999949 GO:0015459 potassium channel regulator activity 5/2613 59/18639 0.0847457627118644 0.604506801066376 0.930381049902606 0.999999999999949 GO:0003779 actin binding 52/2613 443/18639 0.117381489841986 0.837303325359658 0.93177676344998 0.999999999999949 GO:0016798 hydrolase activity, acting on glycosyl bonds 13/2613 130/18639 0.1 0.713318025258324 0.932180991491416 0.999999999999949 GO:0008201 heparin binding 18/2613 172/18639 0.104651162790698 0.746495607828478 0.932441656575163 0.999999999999949 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/2613 40/18639 0.075 0.534988518943743 0.933022717748417 0.999999999999949 GO:0005006 epidermal growth factor receptor activity 4/2613 50/18639 0.08 0.570654420206659 0.933753563992662 0.999999999999949 GO:0005007 fibroblast growth factor receptor activity 4/2613 50/18639 0.08 0.570654420206659 0.933753563992662 0.999999999999949 GO:0005017 platelet-derived growth factor receptor activity 4/2613 50/18639 0.08 0.570654420206659 0.933753563992662 0.999999999999949 GO:0005019 platelet-derived growth factor beta-receptor activity 4/2613 50/18639 0.08 0.570654420206659 0.933753563992662 0.999999999999949 GO:0032813 tumor necrosis factor receptor superfamily binding 4/2613 50/18639 0.08 0.570654420206659 0.933753563992662 0.999999999999949 GO:0008081 phosphoric diester hydrolase activity 8/2613 87/18639 0.0919540229885057 0.655924620927194 0.934092715693382 0.999999999999949 GO:0000400 four-way junction DNA binding 1/2613 18/18639 0.0555555555555556 0.39628779181018 0.934133605410874 0.999999999999949 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/2613 18/18639 0.0555555555555556 0.39628779181018 0.934133605410874 0.999999999999949 GO:0034185 apolipoprotein binding 1/2613 18/18639 0.0555555555555556 0.39628779181018 0.934133605410874 0.999999999999949 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/2613 18/18639 0.0555555555555556 0.39628779181018 0.934133605410874 0.999999999999949 GO:0070851 growth factor receptor binding 14/2613 139/18639 0.100719424460432 0.7184498096127 0.934359112016437 0.999999999999949 GO:0140767 enzyme-substrate adaptor activity 14/2613 139/18639 0.100719424460432 0.7184498096127 0.934359112016437 0.999999999999949 GO:0001965 G-protein alpha-subunit binding 2/2613 30/18639 0.0666666666666667 0.475545350172216 0.93671583396078 0.999999999999949 GO:0022839 monoatomic ion-gated channel activity 2/2613 30/18639 0.0666666666666667 0.475545350172216 0.93671583396078 0.999999999999949 GO:0048019 receptor antagonist activity 2/2613 30/18639 0.0666666666666667 0.475545350172216 0.93671583396078 0.999999999999949 GO:0015370 solute:sodium symporter activity 7/2613 79/18639 0.0886075949367089 0.632053946431426 0.939121217673373 0.999999999999949 GO:0030246 carbohydrate binding 31/2613 280/18639 0.110714285714286 0.789744956536001 0.939247032907618 0.999999999999949 GO:0001727 lipid kinase activity 3/2613 41/18639 0.0731707317073171 0.5219400184817 0.939926653633234 0.999999999999949 GO:0005010 insulin-like growth factor receptor activity 4/2613 51/18639 0.0784313725490196 0.559465117849666 0.939997471816662 0.999999999999949 GO:0005021 vascular endothelial growth factor receptor activity 4/2613 51/18639 0.0784313725490196 0.559465117849666 0.939997471816662 0.999999999999949 GO:0004497 monooxygenase activity 10/2613 106/18639 0.0943396226415094 0.67294153326257 0.9402827578358 0.999999999999949 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/2613 19/18639 0.0526315789473684 0.375430539609644 0.943376336148288 0.999999999999949 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2613 19/18639 0.0526315789473684 0.375430539609644 0.943376336148288 0.999999999999949 GO:0022821 solute:potassium antiporter activity 1/2613 19/18639 0.0526315789473684 0.375430539609644 0.943376336148288 0.999999999999949 GO:0030506 ankyrin binding 1/2613 19/18639 0.0526315789473684 0.375430539609644 0.943376336148288 0.999999999999949 GO:0034987 immunoglobulin receptor binding 1/2613 19/18639 0.0526315789473684 0.375430539609644 0.943376336148288 0.999999999999949 GO:0042577 lipid phosphatase activity 1/2613 19/18639 0.0526315789473684 0.375430539609644 0.943376336148288 0.999999999999949 GO:0042834 peptidoglycan binding 1/2613 19/18639 0.0526315789473684 0.375430539609644 0.943376336148288 0.999999999999949 GO:0140036 ubiquitin-modified protein reader activity 1/2613 19/18639 0.0526315789473684 0.375430539609644 0.943376336148288 0.999999999999949 GO:0005164 tumor necrosis factor receptor binding 2/2613 31/18639 0.0645161290322581 0.460205177586015 0.944093070010473 0.999999999999949 GO:0017147 Wnt-protein binding 2/2613 31/18639 0.0645161290322581 0.460205177586015 0.944093070010473 0.999999999999949 GO:0051015 actin filament binding 22/2613 209/18639 0.105263157894737 0.750861079219288 0.945513645720621 0.999999999999949 GO:0005539 glycosaminoglycan binding 26/2613 242/18639 0.107438016528926 0.766374737880844 0.94603832436868 0.999999999999949 GO:0004252 serine-type endopeptidase activity 18/2613 176/18639 0.102272727272727 0.729529798559649 0.946252038750022 0.999999999999949 GO:0061134 peptidase regulator activity 24/2613 226/18639 0.106194690265487 0.757505867530963 0.947045156342467 0.999999999999949 GO:1990782 protein tyrosine kinase binding 11/2613 117/18639 0.094017094017094 0.670640878447997 0.949066919233865 0.999999999999949 GO:0008236 serine-type peptidase activity 20/2613 194/18639 0.103092783505155 0.735379407482808 0.950061142293974 0.999999999999949 GO:0005003 ephrin receptor activity 4/2613 53/18639 0.0754716981132075 0.538353226610056 0.950903086013834 0.999999999999949 GO:0005005 transmembrane-ephrin receptor activity 4/2613 53/18639 0.0754716981132075 0.538353226610056 0.950903086013834 0.999999999999949 GO:0008146 sulfotransferase activity 4/2613 53/18639 0.0754716981132075 0.538353226610056 0.950903086013834 0.999999999999949 GO:0038064 collagen receptor activity 4/2613 53/18639 0.0754716981132075 0.538353226610056 0.950903086013834 0.999999999999949 GO:0001972 retinoic acid binding 1/2613 20/18639 0.05 0.356659012629162 0.951322503368724 0.999999999999949 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2613 20/18639 0.05 0.356659012629162 0.951322503368724 0.999999999999949 GO:0016505 peptidase activator activity involved in apoptotic process 1/2613 20/18639 0.05 0.356659012629162 0.951322503368724 0.999999999999949 GO:0008375 acetylglucosaminyltransferase activity 3/2613 43/18639 0.0697674418604651 0.497663738552319 0.951797999351313 0.999999999999949 GO:0008083 growth factor activity 16/2613 162/18639 0.0987654320987654 0.704511629884764 0.954861117928797 0.999999999999949 GO:0008194 UDP-glycosyltransferase activity 14/2613 145/18639 0.096551724137931 0.688720851973554 0.955297534035693 0.999999999999949 GO:0001540 amyloid-beta binding 7/2613 83/18639 0.0843373493975904 0.601593515278104 0.956365569614402 0.999999999999949 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/2613 44/18639 0.0681818181818182 0.486353199039766 0.956875642178779 0.999999999999949 GO:0005096 GTPase activator activity 29/2613 271/18639 0.107011070110701 0.763329252121453 0.956900475832342 0.999999999999949 GO:0008373 sialyltransferase activity 1/2613 21/18639 0.0476190476190476 0.339675250123011 0.958153928187325 0.999999999999949 GO:0017171 serine hydrolase activity 20/2613 198/18639 0.101010101010101 0.720523257836691 0.960280216946273 0.999999999999949 GO:0051427 hormone receptor binding 2/2613 34/18639 0.0588235294117647 0.419598838387249 0.961617934076395 0.999999999999949 GO:0005253 monoatomic anion channel activity 9/2613 103/18639 0.087378640776699 0.623287594885914 0.961771405637182 0.999999999999949 GO:0016298 lipase activity 12/2613 130/18639 0.0923076923076923 0.65844740793076 0.962179964191618 0.999999999999949 GO:0008970 phospholipase A1 activity 1/2613 22/18639 0.0454545454545455 0.324235466026511 0.964026942777857 0.999999999999949 GO:0016881 acid-amino acid ligase activity 1/2613 22/18639 0.0454545454545455 0.324235466026511 0.964026942777857 0.999999999999949 GO:0033691 sialic acid binding 1/2613 22/18639 0.0454545454545455 0.324235466026511 0.964026942777857 0.999999999999949 GO:0050321 tau-protein kinase activity 1/2613 22/18639 0.0454545454545455 0.324235466026511 0.964026942777857 0.999999999999949 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 11/2613 122/18639 0.0901639344262295 0.64315559654439 0.964512188034039 0.999999999999949 GO:0004713 protein tyrosine kinase activity 13/2613 140/18639 0.0928571428571429 0.662366737739872 0.96521152658042 0.999999999999949 GO:0004180 carboxypeptidase activity 3/2613 46/18639 0.0652173913043478 0.465207407777168 0.965562197491339 0.999999999999949 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/2613 46/18639 0.0652173913043478 0.465207407777168 0.965562197491339 0.999999999999949 GO:0061135 endopeptidase regulator activity 18/2613 184/18639 0.0978260869565217 0.697811111665751 0.966746961240727 0.999999999999949 GO:0005158 insulin receptor binding 1/2613 23/18639 0.0434782608695652 0.310138271851445 0.969075962411603 0.999999999999949 GO:0005212 structural constituent of eye lens 1/2613 23/18639 0.0434782608695652 0.310138271851445 0.969075962411603 0.999999999999949 GO:0016849 phosphorus-oxygen lyase activity 1/2613 23/18639 0.0434782608695652 0.310138271851445 0.969075962411603 0.999999999999949 GO:0031681 G-protein beta-subunit binding 1/2613 23/18639 0.0434782608695652 0.310138271851445 0.969075962411603 0.999999999999949 GO:0045505 dynein intermediate chain binding 2/2613 36/18639 0.0555555555555556 0.39628779181018 0.9702255105593 0.999999999999949 GO:0030695 GTPase regulator activity 55/2613 489/18639 0.112474437627812 0.802300437407113 0.971021646205375 0.999999999999949 GO:0060589 nucleoside-triphosphatase regulator activity 55/2613 490/18639 0.112244897959184 0.80066308957567 0.972170161004994 0.999999999999949 GO:0005178 integrin binding 15/2613 161/18639 0.093167701863354 0.66458201111024 0.972530971432014 0.999999999999949 GO:0004806 triacylglycerol lipase activity 1/2613 24/18639 0.0416666666666667 0.297215843857635 0.973416557073103 0.999999999999949 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/2613 24/18639 0.0416666666666667 0.297215843857635 0.973416557073103 0.999999999999949 GO:0031593 polyubiquitin modification-dependent protein binding 4/2613 59/18639 0.0677966101694915 0.483605440853101 0.973608605192855 0.999999999999949 GO:0030280 structural constituent of skin epidermis 2/2613 37/18639 0.0540540540540541 0.385577310950445 0.973798657346661 0.999999999999949 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/2613 60/18639 0.0666666666666667 0.475545350172216 0.976262715932286 0.999999999999949 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/2613 25/18639 0.04 0.28532721010333 0.97714809273617 0.999999999999949 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/2613 91/18639 0.0769230769230769 0.548706173275634 0.978320617095528 0.999999999999949 GO:0072341 modified amino acid binding 7/2613 91/18639 0.0769230769230769 0.548706173275634 0.978320617095528 0.999999999999949 GO:0015026 coreceptor activity 4/2613 61/18639 0.0655737704918033 0.467749524759557 0.978664190631151 0.999999999999949 GO:0015085 calcium ion transmembrane transporter activity 13/2613 147/18639 0.0884353741496599 0.630825464514164 0.978887510239688 0.999999999999949 GO:0030247 polysaccharide binding 1/2613 26/18639 0.0384615384615385 0.274353086637817 0.980356002571798 0.999999999999949 GO:0015144 carbohydrate transmembrane transporter activity 2/2613 40/18639 0.05 0.356659012629162 0.98220169267056 0.999999999999949 GO:0005201 extracellular matrix structural constituent 15/2613 168/18639 0.0892857142857143 0.636891093980646 0.983088732344705 0.999999999999949 GO:0005044 scavenger receptor activity 1/2613 27/18639 0.037037037037037 0.264191861206787 0.983113739920957 0.999999999999949 GO:0005104 fibroblast growth factor receptor binding 1/2613 27/18639 0.037037037037037 0.264191861206787 0.983113739920957 0.999999999999949 GO:0008395 steroid hydroxylase activity 1/2613 27/18639 0.037037037037037 0.264191861206787 0.983113739920957 0.999999999999949 GO:0015252 proton channel activity 1/2613 27/18639 0.037037037037037 0.264191861206787 0.983113739920957 0.999999999999949 GO:0004175 endopeptidase activity 43/2613 405/18639 0.106172839506173 0.757350002126122 0.983344026511218 0.999999999999949 GO:0030414 peptidase inhibitor activity 15/2613 169/18639 0.0887573964497041 0.633122507625731 0.984249807269465 0.999999999999949 GO:0001530 lipopolysaccharide binding 2/2613 41/18639 0.0487804878048781 0.347960012321134 0.984369643390423 0.999999999999949 GO:0042287 MHC protein binding 2/2613 41/18639 0.0487804878048781 0.347960012321134 0.984369643390423 0.999999999999949 GO:0005544 calcium-dependent phospholipid binding 3/2613 53/18639 0.0566037735849057 0.403764919957542 0.984661600639423 0.999999999999949 GO:0004867 serine-type endopeptidase inhibitor activity 7/2613 95/18639 0.0736842105263158 0.525602755453502 0.984947911203564 0.999999999999949 GO:0004866 endopeptidase inhibitor activity 14/2613 161/18639 0.0869565217391304 0.62027654370289 0.985350013019142 0.999999999999949 GO:0051959 dynein light intermediate chain binding 1/2613 28/18639 0.0357142857142857 0.254756437592258 0.985484457607747 0.999999999999949 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/2613 86/18639 0.0697674418604651 0.497663738552319 0.986299225406985 0.999999999999949 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 26/2613 268/18639 0.0970149253731343 0.692024949877478 0.987049791492873 0.999999999999949 GO:0004629 phospholipase C activity 1/2613 29/18639 0.0344827586206897 0.245971732847698 0.98752245192675 0.999999999999949 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/2613 29/18639 0.0344827586206897 0.245971732847698 0.98752245192675 0.999999999999949 GO:0099604 ligand-gated calcium channel activity 1/2613 29/18639 0.0344827586206897 0.245971732847698 0.98752245192675 0.999999999999949 GO:0015103 inorganic anion transmembrane transporter activity 14/2613 165/18639 0.0848484848484849 0.60523953658282 0.98912335453876 0.999999999999949 GO:0019199 transmembrane receptor protein kinase activity 5/2613 78/18639 0.0641025641025641 0.457255144396361 0.989176998880649 0.999999999999949 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/2613 30/18639 0.0333333333333333 0.237772675086108 0.989274404270404 0.999999999999949 GO:0046332 SMAD binding 5/2613 79/18639 0.0632911392405063 0.451467104593876 0.990249848533709 0.999999999999949 GO:0005085 guanyl-nucleotide exchange factor activity 21/2613 230/18639 0.091304347826087 0.651290370888035 0.990743639891941 0.999999999999949 GO:0008009 chemokine activity 2/2613 45/18639 0.0444444444444444 0.317030233448144 0.990744191859935 0.999999999999949 GO:0005184 neuropeptide hormone activity 1/2613 31/18639 0.032258064516129 0.230102588793008 0.990780448745735 0.999999999999949 GO:0015108 chloride transmembrane transporter activity 9/2613 121/18639 0.0743801652892562 0.5305671262252 0.991548918492024 0.999999999999949 GO:0160041 neuropeptide activity 1/2613 32/18639 0.03125 0.222911882893226 0.992075090159503 0.999999999999949 GO:0001217 DNA-binding transcription repressor activity 26/2613 278/18639 0.0935251798561151 0.667131966068936 0.992964604836267 0.999999999999949 GO:0005254 chloride channel activity 5/2613 83/18639 0.0602409638554217 0.429709653770075 0.993612139058827 0.999999999999949 GO:0038187 pattern recognition receptor activity 2/2613 48/18639 0.0416666666666667 0.297215843857635 0.993777896343943 0.999999999999949 GO:0015020 glucuronosyltransferase activity 1/2613 34/18639 0.0294117647058824 0.209799419193625 0.994144661798863 0.999999999999949 GO:0035254 glutamate receptor binding 2/2613 49/18639 0.0408163265306122 0.291150214391153 0.994553303290205 0.999999999999949 GO:0048020 CCR chemokine receptor binding 2/2613 50/18639 0.04 0.28532721010333 0.995233688300202 0.999999999999949 GO:0005543 phospholipid binding 51/2613 497/18639 0.10261569416499 0.731976243222827 0.995371964254855 0.999999999999949 GO:0043394 proteoglycan binding 1/2613 37/18639 0.027027027027027 0.192788655475223 0.996281567847744 0.999999999999949 GO:0005179 hormone activity 9/2613 132/18639 0.0681818181818182 0.486353199039766 0.996900149820809 0.999999999999949 GO:0019955 cytokine binding 10/2613 144/18639 0.0694444444444444 0.495359739762725 0.997404939117422 0.999999999999949 GO:0042379 chemokine receptor binding 3/2613 72/18639 0.0416666666666667 0.297215843857635 0.998495378106372 0.999999999999949 GO:0005245 voltage-gated calcium channel activity 1/2613 43/18639 0.0232558139534884 0.165887912850773 0.998500755055978 0.999999999999949 GO:0005262 calcium channel activity 8/2613 131/18639 0.0610687022900763 0.435614061226457 0.99875251635428 0.999999999999949 GO:0015081 sodium ion transmembrane transporter activity 11/2613 164/18639 0.0670731707317073 0.478445016941559 0.998957580102041 0.999999999999949 GO:0008188 neuropeptide receptor activity 1/2613 48/18639 0.0208333333333333 0.148607921928817 0.999296882001654 0.999999999999949 GO:0001664 G protein-coupled receptor binding 24/2613 297/18639 0.0808080808080808 0.576418606269353 0.999450069614377 0.999999999999949 GO:0005272 sodium channel activity 1/2613 51/18639 0.0196078431372549 0.139866279462416 0.999553649782305 0.999999999999949 GO:0004896 cytokine receptor activity 4/2613 96/18639 0.0416666666666667 0.297215843857635 0.999627458245021 0.999999999999949 GO:0008528 G protein-coupled peptide receptor activity 6/2613 122/18639 0.0491803278688525 0.350812143569667 0.999696435332403 0.999999999999949 GO:0005126 cytokine receptor binding 20/2613 275/18639 0.0727272727272727 0.518776745642417 0.999845085241935 0.999999999999949 GO:0001653 peptide receptor activity 6/2613 128/18639 0.046875 0.334367824339839 0.999846420759135 0.999999999999949 GO:0001786 phosphatidylserine binding 1/2613 59/18639 0.0169491525423729 0.120901360213275 0.999867188910944 0.999999999999949 GO:0046873 metal ion transmembrane transporter activity 38/2613 450/18639 0.0844444444444444 0.602357443551473 0.999907665314733 0.999999999999949 GO:0001216 DNA-binding transcription activator activity 41/2613 491/18639 0.0835030549898167 0.595642342883733 0.999964746344329 0.999999999999949 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 40/2613 484/18639 0.0826446280991736 0.58951902913911 0.999969657398122 0.999999999999949 GO:0005125 cytokine activity 13/2613 234/18639 0.0555555555555556 0.39628779181018 0.999991156856516 0.999999999999949 GO:0030527 structural constituent of chromatin 2/2613 98/18639 0.0204081632653061 0.145575107195576 0.999993894688746 0.999999999999949 GO:0099094 ligand-gated monoatomic cation channel activity 4/2613 136/18639 0.0294117647058824 0.209799419193625 0.999997686574705 0.999999999999949 GO:0140375 immune receptor activity 5/2613 156/18639 0.032051282051282 0.228627572198181 0.999998921867384 0.999999999999949 GO:0003823 antigen binding 6/2613 174/18639 0.0344827586206897 0.245971732847698 0.999999380860034 0.999999999999949 GO:0005244 voltage-gated monoatomic ion channel activity 5/2613 173/18639 0.0289017341040462 0.206161278976394 0.999999879057796 0.999999999999949 GO:0015079 potassium ion transmembrane transporter activity 4/2613 160/18639 0.025 0.178329506314581 0.999999904029795 0.999999999999949 GO:0022832 voltage-gated channel activity 5/2613 175/18639 0.0285714285714286 0.203805150073807 0.999999906752962 0.999999999999949 GO:0022834 ligand-gated channel activity 5/2613 188/18639 0.0265957446808511 0.189712240760192 0.999999983011802 0.999999999999949 GO:0005267 potassium channel activity 1/2613 124/18639 0.00806451612903226 0.0575256471982519 0.999999993132432 0.999999999999949 GO:0015276 ligand-gated monoatomic ion channel activity 4/2613 186/18639 0.021505376344086 0.153401725862005 0.999999997171962 0.999999999999949 GO:0045182 translation regulator activity 16/2613 356/18639 0.0449438202247191 0.320592370902617 0.999999999259745 0.999999999999949 GO:0022843 voltage-gated monoatomic cation channel activity 1/2613 143/18639 0.00699300699300699 0.049882379388694 0.999999999619131 0.999999999999949 GO:0022836 gated channel activity 10/2613 318/18639 0.0314465408805031 0.224313844420857 0.999999999991643 0.999999999999949 GO:0005216 monoatomic ion channel activity 20/2613 448/18639 0.0446428571428571 0.318445546990323 0.999999999994853 0.999999999999949 GO:0005261 monoatomic cation channel activity 11/2613 341/18639 0.032258064516129 0.230102588793008 0.999999999997427 0.999999999999949 GO:0030371 translation repressor activity 8/2613 329/18639 0.0243161094224924 0.173451191552176 0.999999999999949 0.999999999999949