category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	81/709	268/9376	3.99688440730059	CALM3/TUBA1B/CALM1/TUBA1C/TUBB/PSMA7/GNAS/COX5B/NDUFA4/TUBB6/UQCRH/NDUFV3/COX5A/PSMB6/RPS27A/HSPA5/TUBB4B/PSMB1/PSMB2/VDAC2/PARK7/NDUFS8/UBE2L3/PSMB5/PSMA4/SLC39A4/COX8C/PSMB3/SLC25A5/NDUFV2/TXN2/NDUFA6/COX4I1/COX7C/NDUFC1/SLC39A10/NDUFB11/MT-CO3/NDUFA3/PSMD11/PSMD4/PSMA1/PSMA3/SLC25A6/PSMD8/TRAP1/UQCRB/PSMC3/PSMD2/NDUFS5/ADRM1/PSMD7/SNCA/VDAC1/PSMB4/MT-CO2/VDAC3/PSMC5/NDUFS2/PSMD3/MAOA/PSMC4/NDUFS3/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/PSMD13/COX7A2L/NDUFV1/NDUFB7/GNAI1/UBE2G1/PSMD12/CALM2/EIF2S1/NDUFA8/UQCRC1/NDUFS7/NDUFA9/SDHA	14.2364017634595
Genetic Information Processing	Translation	hsa03010	Ribosome	63/709	222/9376	3.75283040445241	RPL29/RPS3A/RPL7A/RPS4X/RPL13/RPL11/RPS2/RPLP0/RPL36/RPL36AL/RPL19/RPS15/RPL8/MRPS15/RPSA/RPL18/RPL14/RPL22L1/RPS3/RPL5/RPL37A/RPL18A/MRPL51/RPS27A/MRPL23/RPL15/MRPS6/RPL6/RPS5/MRPL11/MRPL41/MRPS16/MRPL40/MRPL16/MRPL13/MRPL22/MRPL37/MRPS33/MRPS12/MRPL14/RPL26L1/DAP3/MRPS7/MRPL17/MRPL27/MRPL21/MRPL47/MRPL12/MRPS23/MRPL54/MRPL15/MRPL20/MRPS34/MRPL3/MRPS21/MRPL4/MRPS14/MRPS22/MRPL24/MRPL43/MRPL9/MRPL34/MRPL35	11.8720262179333
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	71/709	275/9376	3.41426336709835	CYBA/TUBA1B/TUBA1C/TUBB/PSMA7/COX5B/NDUFA4/TUBB6/UQCRH/NDUFV3/RAC1/COX5A/PSMB6/HSPA5/TUBB4B/PSMB1/PSMB2/VDAC2/NDUFS8/PSMB5/PSMA4/COX8C/PSMB3/SLC25A5/NDUFV2/NDUFA6/COX4I1/CAV1/COX7C/NDUFC1/NDUFB11/MT-CO3/NDUFA3/PSMD11/PSMD4/PSMA1/NCF1/PSMA3/SLC25A6/PSMD8/UQCRB/PSMC3/PSMD2/NDUFS5/ADRM1/PSMD7/VDAC1/PSMB4/MT-CO2/VDAC3/PSMC5/NDUFS2/MAPK13/PSMD3/PSMC4/NDUFS3/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/PSMD13/COX7A2L/NDUFV1/NDUFB7/PSMD12/EIF2S1/NDUFA8/UQCRC1/NDUFS7/NDUFA9/SDHA	11.6219978802556
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	75/709	308/9376	3.22019306504497	TUBA1B/TUBA1C/TUBB/PSMA7/COX5B/NDUFA4/TUBB6/UQCRH/NDUFV3/COX5A/PSMB6/TUBB4B/PSMB1/PSMB2/VDAC2/TGM2/NDUFS8/PSMB5/PSMA4/COX8C/PSMB3/SLC25A5/NDUFV2/NDUFA6/COX4I1/CLTA/COX7C/NDUFC1/POLR2I/NDUFB11/MT-CO3/NDUFA3/PSMD11/PSMD4/PSMA1/PSMA3/SLC25A6/PSMD8/UQCRB/PSMC3/PSMD2/NDUFS5/ADRM1/PSMD7/VDAC1/PSMB4/MT-CO2/VDAC3/PSMC5/NDUFS2/POLR2H/PSMD3/PSMC4/NDUFS3/POLR2F/AP2S1/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/NRBF2/PSMD13/COX7A2L/NDUFV1/NDUFB7/PSMD12/IFT57/POLR2E/ACTR1A/NDUFA8/UQCRC1/NDUFS7/NDUFA9/PLCB3/SDHA	11.3314295179917
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	82/709	388/9376	2.79481773370363	CALM3/TUBA1B/GAPDH/CALM1/TUBA1C/TUBB/PSMA7/COX5B/NDUFA4/TUBB6/UQCRH/NDUFV3/COX5A/PSMB6/HSD17B10/TUBB4B/PSMB1/PSMB2/VDAC2/NDUFS8/PSMB5/PSMA4/SLC39A4/COX8C/PSMB3/SLC25A5/NDUFV2/NDUFA6/COX4I1/COX7C/NDUFC1/SLC39A10/NDUFB11/MAP2K2/MT-CO3/NDUFA3/DKK1/PSMD11/PSMD4/PSMA1/PSMA3/SLC25A6/PSMD8/UQCRB/PSMC3/PSMD2/NDUFS5/ADRM1/PSMD7/SNCA/VDAC1/PSMB4/MT-CO2/VDAC3/PSMC5/NDUFS2/PSMD3/PSMC4/APP/NDUFS3/CAPN1/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/NRBF2/PSMD13/COX7A2L/NDUFV1/NDUFB7/PSMD12/CALM2/EIF2S1/WNT3A/WNT10B/NDUFA8/UQCRC1/NDUFS7/NDUFA9/PLCB3/SDHA/WNT2	10.3271156450823
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	93/709	480/9376	2.56220028208745	CALM3/TUBA1B/CALM1/TUBA1C/TUBB/PSMA7/COX5B/NDUFA4/TUBB6/UQCRH/NDUFV3/RAC1/COX5A/PSMB6/RPS27A/HSD17B10/HSPA5/TUBB4B/PSMB1/PSMB2/VDAC2/PARK7/NDUFS8/UBE2L3/PSMB5/PSMA4/COX8C/PSMB3/SLC25A5/NDUFV2/NDUFA6/COX4I1/COX7C/NDUFC1/NDUFB11/MAP2K2/MT-CO3/NDUFA3/DKK1/PSMD11/PSMD4/PSMA1/PSMA3/SLC25A6/PSMD8/TRAP1/UQCRB/PSMC3/PSMD2/NDUFS5/ADRM1/PSMD7/VCP/SNCA/VDAC1/PSMB4/MT-CO2/VDAC3/PSMC5/NDUFS2/MAPK13/PSMD3/DERL1/PSMC4/APP/NDUFS3/CAPN1/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/NRBF2/PSMD13/COX7A2L/NDUFV1/NDUFB7/UBE2G1/PSMD12/CALM2/IFT57/EIF2S1/ACTR1A/WNT3A/WNT10B/NDUFA8/UQCRC1/NDUFS7/TOMM40/NDUFA9/CCS/PLCB3/SDHA/WNT2	10.0492650511144
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	78/709	368/9376	2.80296805053045	TUBA1B/TUBA1C/PFN1/TUBB/PSMA7/ACTB/COX5B/NDUFA4/TUBB6/UQCRH/NDUFV3/RAC1/COX5A/PSMB6/ACTG1/HSPA5/TUBB4B/PSMB1/PSMB2/NDUFS8/PSMB5/PSMA4/COX8C/PSMB3/NDUFV2/ALYREF/NDUFA6/COX4I1/COX7C/NDUFC1/NDUFB11/MT-CO3/NDUFA3/PSMD11/PSMD4/PSMA1/PSMA3/PSMD8/HNRNPA3/UQCRB/PSMC3/PSMD2/NDUFS5/ADRM1/PSMD7/VCP/VDAC1/PSMB4/MT-CO2/PSMC5/NDUFS2/MAPK13/PSMD3/DERL1/PSMC4/NDUFS3/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/NUP37/NRBF2/PSMD13/COX7A2L/SEC13/NDUFV1/NDUFB7/PSMD12/EIF2S1/ACTR1A/NDUFA8/CHCHD10/UQCRC1/NDUFS7/TOMM40/NDUFA9/CCS/SDHA	10.0918807246345
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	25/709	46/9376	7.18709756546268	PSMA7/PSMB6/POMP/PSMB1/PSMB2/PSMB5/PSMA4/PSMB3/PSMD11/PSMD4/PSMA1/PSMA3/PSMD8/PSMC3/PSMD2/ADRM1/PSMD7/PSMB4/PSME2/PSMC5/PSMD3/PSMC4/PSMD13/PSMD12/PSMF1	12.0309359861676
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	54/709	205/9376	3.48346348343596	CYBA/GAPDH/COL1A1/COL3A1/COX5B/NDUFA4/UQCRH/NDUFV3/RAC1/COX5A/MMP2/VDAC2/PPP1CA/NDUFS8/PTEN/COX8C/SLC25A5/COL1A2/NDUFV2/NDUFA6/COX4I1/COX7C/NDUFC1/PRKCZ/NDUFB11/MT-CO3/NDUFA3/NCF1/SLC25A6/UQCRB/NDUFS5/VDAC1/MT-CO2/VDAC3/SLC2A1/NDUFS2/MAPK13/NDUFS3/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/REN/COX7A2L/NDUFV1/NDUFB7/PDHA1/GYS1/NDUFA8/UQCRC1/NDUFS7/NDUFA9/PLCB3/SDHA	10.2825473929005
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	51/709	227/9376	2.97108914336131	CYBA/MGST1/COX5B/NDUFA4/UQCRH/NDUFV3/CBR1/RAC1/COX5A/ACP1/VDAC2/NDUFS8/PTEN/COX8C/SLC25A5/NDUFV2/NDUFA6/COX4I1/MGST3/COX7C/NDUFC1/NDUFB11/MAP2K2/MT-CO3/NDUFA3/NCF1/SLC25A6/UQCRB/NDUFS5/VDAC1/MT-CO2/VDAC3/NDUFS2/MAPK13/GRB2/NDUFS3/GSTA4/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/SLC26A1/COX7A2L/NDUFV1/NDUFB7/NDUFA8/UQCRC1/NQO1/NDUFS7/NDUFA9/SDHA	8.5981840685733
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	35/709	138/9376	3.35397886388259	ATP6V1F/COX5B/NDUFA4/UQCRH/NDUFV3/COX5A/PPA1/NDUFS8/ATP6V1B1/COX8C/NDUFV2/NDUFA6/COX4I1/COX7C/NDUFC1/NDUFB11/MT-CO3/NDUFA3/UQCRB/NDUFS5/MT-CO2/NDUFS2/NDUFS3/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/COX7A2L/NDUFV1/NDUFB7/NDUFA8/UQCRC1/NDUFS7/NDUFA9/SDHA	7.96759922691083
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	37/709	157/9376	3.11654523730382	LEP/COX5B/NDUFA4/UQCRH/NDUFV3/RAC1/COX5A/NDUFS8/COX8C/NDUFV2/NDUFA6/COX4I1/COX7C/NDUFC1/NDUFB11/SOCS3/MT-CO3/NDUFA3/UQCRB/NDUFS5/MT-CO2/NDUFS2/MAPK13/NDUFS3/MT-CO1/NDUFA12/NDUFB3/NDUFAB1/COX7A2L/NDUFV1/NDUFB7/EIF2S1/NDUFA8/UQCRC1/NDUFS7/NDUFA9/SDHA	7.64909106526241
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	47/709	235/9376	2.64485190409027	GNAS/ACTB/COX5B/NDUFA4/UQCRH/NDUFV3/COX5A/ACTG1/NDUFS8/COX8C/NDUFV2/NDUFA6/COX4I1/COX7C/NDUFC1/NDUFB11/MT-CO3/NDUFA3/SMARCA2/CPT1C/NDUFAF2/UQCRB/NDUFS5/NDUFAF3/MT-CO2/NDUFS2/MAPK13/COX20/GRB2/NDUFS3/ACSL4/MT-CO1/NDUFA12/COA6/NDUFB3/NDUFAB1/COX7A2L/RPS6KB2/NDUFV1/NDUFB7/NPR1/KDM1A/NDUFA8/UQCRC1/NDUFS7/NDUFA9/SDHA	7.30362112451661
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	29/709	116/9376	3.30606488011284	TPI1/GAPDH/PGK1/PKM/TALDO1/ENO1/GPT2/PHGDH/ADH5/TKT/IDH2/PGAM1/ALDOA/MDH2/MDH1/GPI/PGLS/PRPS2/ALDOC/PFKP/ACAT2/PFKM/PRPS1/ACAT1/PDHA1/HK2/FH/ESD/SDHA	7.14775043446224
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	30/709	144/9376	2.7550540667607	PSMA7/PSMB6/PSMB1/PSMB2/VDAC2/PSMB5/PSMA4/PSMB3/SLC25A5/PSMD11/PSMD4/PSMA1/PSMA3/SLC25A6/PSMD8/PSMC3/PSMD2/ADRM1/PSMD7/VDAC1/PSMB4/VDAC3/PSMC5/PSMD3/PSMC4/NOP56/NRBF2/PSMD13/PSMD12/PLCB3	6.07013298408016
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	20/709	75/9376	3.52646920545369	TPI1/GAPDH/CBS/PGK1/PKM/TALDO1/ENO1/GPT2/PHGDH/TKT/IDH2/PGAM1/ALDOA/PRPS2/ALDOC/PFKP/PFKM/PRPS1/ARG2/ASNS	6.28281361380419
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/709	85/9376	3.26716999917033	RRM2/ADA/TYMS/TK1/GUK1/NME1/ADK/IMPDH2/IMPDH1/AK2/NTPCR/AK1/DTYMK/APRT/NME2/PNP/GMPS/HDDC2/AK4/CDA/NT5C	6.0053272203494
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	18/709	67/9376	3.55278613982275	LDHA/TPI1/GAPDH/LDHB/PGK1/PKM/ENO1/ADH5/PGAM1/ALDOA/GPI/ALDOC/PFKP/ALDH2/PFKM/ALDH7A1/PDHA1/HK2	5.99756104339912
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	19/709	87/9376	2.88805667688018	TPM2/COX5B/UQCRH/TPM4/COX5A/ATP1B3/COX8C/COX4I1/MYL3/COX7C/MT-CO3/UQCRB/MT-CO2/SLC8A1/MYL4/MT-CO1/COX7A2L/TNNC1/UQCRC1	5.06016326484481
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	24/709	128/9376	2.47954866008463	RRM2/ADA/PAICS/PDE4D/GUK1/NME1/ADK/IMPDH2/PRPS2/IMPDH1/AK2/NTPCR/AK1/NUDT5/APRT/NME2/PNP/GMPS/PRPS1/HDDC2/NPR1/AK4/NUDT2/NT5C	4.82041783703141
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/709	174/9376	2.20404325340856	LMAN1/SSR2/CALR/PDIA6/OSTC/SSR3/ERP29/PDIA3/LMAN2/TUSC3/CKAP4/HSPA5/DAD1/SEC61B/DNAJB11/HSP90B1/PDIA4/VCP/UBXN1/DNAJC3/SAR1A/DERL1/CAPN1/DERL2/SEC13/UBE2G1/EIF2S1/RAD23A/SVIP	4.58511207554451
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/709	31/9376	4.26589016788753	TALDO1/TKT/ALDOA/GPI/PGLS/PRPS2/ALDOC/PFKP/PFKM/PRPS1	5.2091531609024
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/709	31/9376	4.26589016788753	SEC11A/SPCS3/SEC11C/SRP14/HSPA5/SEC61B/SRP72/SPCS1/TMEM208/SRPRB	5.2091531609024
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/709	71/9376	2.98011482151016	LDHA/LDHB/PKM/IDH2/PGAM1/PTEN/SLC7A5/MAP2K2/MYC/PFKP/SLC2A1/SLC16A3/GLS/PFKM/PDHA1/HK2	4.79000225304698
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/709	59/9376	3.13795988620879	GSTP1/MGST1/ODC1/PRDX6/RRM2/IDH2/MGST3/SRM/SMS/GSTA4/GCLM/ANPEP/LAP3/TXNDC12	4.7115289937693
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	26/709	158/9376	2.17614397171984	PTTG1/CHEK1/CDC20/CCND3/CDK1/ANAPC11/CCNA2/CDT1/MYC/SFN/RAD21/SKP2/CCNB2/AURKB/NDC80/CCNB1/PKMYT1/MCM7/ESCO2/CDC6/PLK1/SMC1A/BUB1/MAD2L1/CDC45/BUB1B	4.26427334840004
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/709	47/9376	3.37640668607268	LDHA/LDHB/PKM/ADH5/MDH2/MDH1/ACAT2/ALDH2/ACAT1/ALDH7A1/PDHA1/FH	4.67117895410082
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/709	157/9376	2.10577380898907	HLA-C/CALM3/HLA-G/CALM1/EIF4EBP1/VDAC2/PPP1CA/PTEN/SLC25A5/CHEK1/CCND3/CDK1/MAP2K2/CCNA2/MYC/SLC25A6/VDAC1/VDAC3/CCNB2/MYBL2/MAPK13/CCNB1/CAPN1/CALM2/FOXM1	3.99621251342304
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/709	149/9376	2.13008207040827	NDUFA4/NDUFV3/NDUFS8/NDUFV2/NDUFA6/NDUFC1/GNG11/NDUFB11/NDUFA3/NDUFS5/NDUFS2/MAPK13/NDUFS3/NDUFA12/NDUFB3/NDUFAB1/NDUFV1/NDUFB7/GNAI1/GNB2/NDUFA8/NDUFS7/NDUFA9/PLCB3	3.97692330764667
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/709	142/9376	2.14195752796043	CYBA/CALM3/GSTP1/CALM1/MGST1/ACTB/RAC1/ACTG1/MMP2/IL1R2/TXN2/CAV1/SDC1/MGST3/PRKCZ/RAC3/NCF1/HSP90B1/MAPK13/CDH5/GSTA4/CALM2/NQO1	3.92169257911984
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/709	110/9376	2.28419028080523	LDHA/GAPDH/LDHB/EGLN3/TIMP1/PGK1/ENO1/EIF4EBP1/ANGPT4/ALDOA/MAP2K2/ALDOC/PFKP/SLC2A1/PFKM/RPS6KB2/PDHA1/HK2/EGLN1	3.87484139671558
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/709	78/9376	2.54312683085603	ENO1/LSM2/LSM5/HSPD1/DCPS/LSM4/PABPC4/PFKP/EXOSC3/EXOSC8/PFKM/BTG1/EXOSC1/LSM6/EXOSC5	3.91406929775021
Cellular Processes	Cell motility	hsa04814	Motor proteins	28/709	194/9376	1.90865601326102	TUBA1B/TUBA1C/TUBB/TPM2/ACTB/TUBB6/MYO1B/TPM4/DYNLL1/ACTG1/TUBB4B/MYL6/MYL6B/MYL9/MYO10/MYL3/TNNT1/CAPZB/CENPE/ACTA2/MYL4/TUBG1/KIF2C/KIF23/TNNC1/KIF4A/ACTR1A/KIFC1	3.65768316360246
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	32/709	238/9376	1.77805170022875	RPL29/RPS3A/RPL7A/RPS4X/RPL13/RPL11/RPS2/RPLP0/RPL36/RPL36AL/RPL19/RPS15/RPL8/RPSA/RPL18/RPL14/RPL22L1/RPS3/RPL5/RPL37A/RPL18A/RPS27A/RPL15/RPL6/RPS5/ISG15/RPL26L1/C1R/MMP3/MAPK13/C1S/CFD	3.47732846194289
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/709	50/9376	2.90933709449929	ODC1/P4HA2/CKMT1A/SRM/ALDH2/SMS/MAOA/ARG2/ALDH7A1/GAMT/LAP3	3.87163372460157
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/709	54/9376	2.6938306430549	LDHA/LDHB/CBS/PHGDH/MDH2/SRM/CISD1/MDH1/AHCY/SMS/GCLM	3.57015172747672
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/709	15/9376	4.40808650681711	ACP1/AK2/NTPCR/AK1/AK4	3.77806542421043
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	29/709	233/9376	1.64593788022785	COL1A1/ENO1/TPM2/COL3A1/ACTB/TPM4/ACTG1/ATP1B3/DCN/MYL9/COL1A2/MYL3/COL6A2/SDC1/COL5A1/LMNB2/TNNT1/VCAN/COL6A3/CAPZB/FLNC/TLN1/SPTBN1/LMNB1/MYL4/PDLIM2/TNNC1/DIAPH3/CSRP1	2.85560880300423
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/709	116/9376	1.93803803316959	CYBA/ACTB/RAC1/JAM3/CLDN10/ACTG1/CLDN6/MMP2/MYL9/ACTN1/NCF1/THY1/MAPK13/CDH5/ACTN4/GNAI1/ARHGAP5	2.90749051206313
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/709	107/9376	1.97745936754413	CALM3/LDHA/CALM1/PYGL/LDHB/PKM/GNAS/PGAM1/CPT1C/PFKP/SLC2A1/PFKM/CALM2/PDHA1/GYS1/PLCB3	2.90836237980166
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/709	75/9376	2.11588152327221	RRM2/SIVA1/PTEN/CHEK1/SHISA5/CCND3/CDK1/SFN/CCNB2/GTSE1/CCNB1/TP53I3	2.77496975252
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	27/709	224/9376	1.59399556719726	HLA-C/HLA-G/CALR/RAN/RANBP1/PTTG1/VDAC2/IL1R2/PTEN/SLC25A5/CHEK1/CDC20/CCND3/ANAPC11/MAP2K2/CCNA2/MYC/SLC25A6/VDAC1/TLN1/VDAC3/SLC2A1/CCNB2/STAT5B/FDPS/MAD2L1/BUB1B	2.57349639928238
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/709	42/9376	2.51890657532406	VDAC2/SLC3A2/FTH1/VDAC3/ACSL4/GCLM/PCBP2/SLC40A1	2.82160467743139
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	29/709	248/9376	1.54638518585923	TUBA1B/GAPDH/TUBA1C/S100A10/PFN1/TUBB/CASP4/ANXA2/ACTB/RPS3/TUBB6/ARPC3/RAC1/DYNLL1/ACTG1/TUBB4B/MYL9/TXN2/ACTR3/MAP2K2/MYC/HSP90B1/RALA/ARPC1A/MAPK13/PIK3C2B/RIPK2/ACTR1A/FBXO22	2.49408527335113
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/709	59/9376	2.24139991872057	RRM2/TYMS/TK1/NME1/DTYMK/NME2/HDDC2/NUDT2/CDA/NT5C	2.73573500964348
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/709	43/9376	2.46032735264211	ADH5/CPT1C/ACAT2/ALDH2/ACSL4/ACAT1/ALDH7A1/ECI2	2.74503680780644
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/709	35/9376	2.64485190409027	TPI1/ALDOA/ALDOC/PFKP/PFKM/HK2/GMPPA	2.78829355919006
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/709	36/9376	2.57138379564332	SSBP1/RNASEH2C/RPA3/RNASEH2A/POLD2/MCM7/PRIM1	2.70168331133737
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/709	53/9376	2.24562897517098	GNAS/RAB11A/ATP1B3/CLTA/ATP2B4/SLC8A1/AP2S1/PLCB3/ATP2B1	2.60089699090591
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/709	82/9376	1.93525749079776	GSTP1/MGST1/RRM2/TK1/NME1/MGST3/IMPDH2/IMPDH1/GSTA4/NME2/GMPS/CDA	2.43282653996804
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	24/709	205/9376	1.54820599263821	HLA-C/HLA-G/CALR/RAC1/PDIA3/ISG15/CCND3/PSMD11/PSMD4/CCNA2/MYC/PSMD8/PSMC3/PSMD2/ADRM1/PSMD7/SKP2/PSMC5/MAPK13/PSMD3/PSMC4/PSMD13/PSMD12/IRF7	2.26979544413332
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/709	38/9376	2.43604780639893	GNPNAT1/NAGK/GPI/HEXB/HK2/GMPPA/GALK1	2.5369278665929
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/709	30/9376	2.64485190409027	IDH2/MDH2/MDH1/PDHA1/FH/SDHA	2.5807676039015
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/709	39/9376	2.37358504213229	CBS/MTHFD1L/TYMS/AHCY/DHFR/ALDH7A1/MTHFD2	2.45843389201133
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	17/709	138/9376	1.62907544817154	CALM3/CALM1/PTTG1/PPP1CA/CDC20/CDK1/ANAPC11/CCNB2/MAPK13/CCNB1/PKMYT1/CALM2/PLK1/SMC1A/BUB1/MAD2L1/AURKA	2.12925491023872
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/709	41/9376	2.25780040593072	CBS/PHGDH/ALAS2/PGAM1/MAOA/ALDH7A1/GAMT	2.30845203535209
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	23/709	203/9376	1.49831511808069	COL1A1/ACTB/RAC1/ACTG1/PPP1CA/MYL9/PTEN/COL1A2/COL6A2/CAV1/ACTN1/CCND3/RAC3/COL6A3/VEGFB/LAMA4/TLN1/GRB2/ACTN4/TNXB/PAK4/ARHGAP5/PARVA	2.05291393595344
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	23/709	204/9376	1.49097043612932	COL1A1/ACTB/CD63/RAC1/ACTG1/MMP2/PPP1CA/DCN/LUM/COL1A2/CAV1/PLAUR/SDC1/MAP2K2/MYC/MAPK13/GRB2/RPS6KB2/WNT3A/WNT10B/CTTN/HPSE/WNT2	2.02774229564631
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/709	51/9376	2.07439365026688	KDELR2/GNAS/ATP6V1F/ACTB/ACTG1/SEC61B/ATP6V1B1/PDIA4	2.20038389838438
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	18/709	154/9376	1.54569267122159	CALM3/CALM1/GNAS/TPM2/TPM4/ATP1B3/PPP1CA/MYL3/ATP2B4/MAPK13/SLC8A1/CREM/MYL4/GNAI1/TNNC1/CALM2/PLCB3/ATP2B1	1.95285626862328
NA	NA	hsa04518	Integrin signaling	18/709	154/9376	1.54569267122159	COL1A1/ACTB/RAC1/FERMT2/ACTG1/COL1A2/COL6A2/ACTN1/CCND3/RAC3/COL6A3/VEGFB/CDH1/LAMA4/TLN1/ACTN4/TNXB/PARVA	1.95285626862328
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/709	200/9376	1.45466854724965	TUBA1B/GAPDH/TUBA1C/TUBB/CASP4/TMBIM6/ACTB/RPS3/TUBB6/TMED10/MYO1B/ARPC3/RAC1/CLDN10/ACTG1/TUBB4B/CLDN6/MYO10/ACTR3/ARPC1A/MAPK13/CTTN	1.85890658048202
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/709	19/9376	2.78405463588449	HYAL3/IDUA/HEXB/HPSE	2.22633745911738
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/709	36/9376	2.20404325340856	PYGL/GPI/GYG2/GBE1/HK2/GYS1	2.07011398035355
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	18/709	158/9376	1.50656121119066	ATP6V1F/EIF4EBP1/ATP6V1B1/PTEN/SLC3A2/CAB39L/CLIP1/SLC7A5/MAP2K2/LAMTOR2/SKP2/GRB2/SEC13/RPS6KB2/WNT3A/LAMTOR1/WNT10B/WNT2	1.83660803792149
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	23/709	214/9376	1.42129892042234	HLA-C/CALM3/HLA-G/CALM1/CALR/RAC1/PDIA3/CHEK1/CFL1/CDK1/GNG11/RAC3/MAP2K2/CCNB2/MAPK13/CCNB1/RNF7/RPS6KB2/GNAI1/CFL2/CALM2/GNB2/PAK4	1.7831030657863
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/709	170/9376	1.47800547581515	TUBA1B/TUBA1C/ACTB/ARPC3/RAC1/JAM3/CLDN10/ACTG1/MYL6/CLDN6/MYL6B/RAB13/MYL9/ACTR3/ACTN1/PRKCZ/ARPC1A/ACTN4/CTTN	1.79885519462204
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/709	37/9376	2.14447451682995	GNPNAT1/NAGK/GPI/HK2/GMPPA/GALK1	1.99494606578329
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/709	76/9376	1.74003414742781	CALM3/CALM1/GNAS/ACTB/ACTG1/ATP1B3/GAST/GNAI1/CALM2/PLCB3	1.85264171764448
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/709	130/9376	1.52587609851362	COL1A1/GNAS/COL3A1/MMP2/COL1A2/GNG11/PRKCZ/MAP2K2/VEGFB/ACTA2/MAPK13/GRB2/GNAI1/GNB2/PLCB3	1.72684167548165
NA	NA	hsa03272	Virion - Hepatitis viruses	7/709	48/9376	1.92853784673249	CD63/CLDN10/CD9/CLDN6/CD81/CHMP4A/EPCAM	1.84459198632335
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/709	78/9376	1.69541788723735	ACTB/ARPC3/RAC1/ACTG1/ACTR3/CAV1/CLTA/CDH1/ARPC1A/CTTN	1.76389506495204
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/709	89/9376	1.63445904185354	TUBA1B/TUBA1C/TUBB/GNAS/TUBB6/TUBB4B/CDK1/MAP2K2/GRB2/GNAI1/PLCB3	1.72002686061273
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	17/709	154/9376	1.45982085615372	PDXK/MTHFD1L/VKORC1/ALAS2/NME1/AK2/AK1/ALDH2/DHFR/GGH/NME2/AK4/GCLM/NQO1/GMPPA/MTHFD2/ALAD	1.6455490218942
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/709	166/9376	1.43395585161521	CALM3/CALM1/ATP1B3/VDAC2/PPP1CA/MYL9/SLC25A5/MAP2K2/ATP2B4/SLC25A6/VDAC1/VDAC3/SLC8A1/NPR1/GNAI1/CALM2/PLCB3/ATP2B1	1.61340773741081
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/709	155/9376	1.45040265708176	CYBA/HLA-C/HLA-G/TUBA1B/TUBA1C/TUBB/CALR/ATP6V1F/ACTB/TUBB6/RAC1/ACTG1/TUBB4B/SEC61B/ATP6V1B1/NCF1/C1R	1.6171568306059
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/709	212/9376	1.37232881816004	CALM3/CALM1/PFN1/GNAS/ACTB/RALB/RAC1/ACTG1/ANGPT4/PRKCZ/RAC3/MAP2K2/VEGFB/CDH1/ENAH/TLN1/RALA/EPHA2/MAPK13/GNAI1/CALM2/PLCB3	1.56829009489675
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/709	50/9376	1.85139633286319	HBA2/HBA1/GYPC/GYPA/GYPB/CD81/SDC1	1.72640795845411
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/709	61/9376	1.73432911743624	ATP1B3/SLC39A4/ATP2B4/FTH1/SLC6A19/SLC8A1/SLC40A1/ATP2B1	1.64565424537332
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/709	103/9376	1.54069042956715	COL1A1/COL3A1/ATP1B3/COL1A2/SLC3A2/COL6A2/COL5A1/COL6A3/SLC6A19/SLC8A1/COL14A1/COL18A1	1.57808910835572
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/709	23/9376	2.29987122094806	SSBP1/RPA3/POLD2/EXO1	1.78510241264566
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/709	23/9376	2.29987122094806	REN/ANPEP/THOP1/ENPEP	1.78510241264566
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/709	93/9376	1.56415972822543	CALM3/CGA/CALM1/GNAS/MMP2/MAP2K2/MAPK13/GRB2/CALM2/PLCB3/LHB	1.56377309940081
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/709	52/9376	1.78018878159922	CGA/GNAS/HSD3B1/CYP11A1/ACOT4/HSD17B1/LHB	1.61352091098262
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/709	105/9376	1.51134394519444	BNIP3/TOMM20/RPS27A/FKBP8/BNIP3L/MTX1/VCP/PHB2/USP15/TAX1BP1/EIF2S1/TOMM40	1.50701936978308
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/709	34/9376	1.9447440471252	POLR1D/POLR2I/POLR2H/POLR2F/POLR2E	1.57836720496304
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/709	44/9376	1.80330811642518	OSTC/TUSC3/DAD1/ALG9/HEXB/ALG3	1.52755017987547
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/709	142/9376	1.39692882258289	RPS27A/UBE2C/UBE2L3/UBE2F/CDC20/ANAPC11/SOCS3/SKP2/UBE2E3/FBXW7/RNF7/UBE2M/HERC3/UBE2N/UBE2G1	1.36312671868128
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/709	98/9376	1.48435566045882	CALM3/CALM1/GNAS/ATP1B3/HSD3B1/CYP11A1/ATP2B4/NPR1/CALM2/PLCB3/ATP2B1	1.3785565649437
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	12/709	110/9376	1.44264649314015	CDK1/ANAPC11/CCNA2/CCNB2/MAPK13/CCNB1/PKMYT1/GNAI1/PLK1/BUB1/MAD2L1/AURKA	1.33561589849048
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/709	78/9376	1.52587609851362	CALM3/CALM1/CFL1/C1R/MAPK13/C1S/GNAI1/CFL2/CALM2	1.33386021839241
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/709	134/9376	1.38163905437551	CALM3/CALM1/GNAS/MYL6/PPP1CA/MYL6B/MYL9/PLA2G2A/MAP2K2/ACTA2/PPP1R14A/NPR1/CALM2/PLCB3	1.27261367501129
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/709	57/9376	1.62403187093262	SCD/CPT1C/ACAT2/ELOVL2/ACSL4/ACAT1/ELOVL6	1.35155555009429
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/709	27/9376	1.95914955858538	SCD/ACOT4/ELOVL2/ELOVL6	1.42744699592827
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/709	37/9376	1.78706209735829	GPT2/NIT2/GLS/RIMKLA/ASNS	1.3719365626429
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/709	37/9376	1.78706209735829	HBA2/HBA1/LAMA4/THOP1/PLCB3	1.3719365626429
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	24/709	253/9376	1.25447521142621	BNIP3/PFN1/CASP4/ACTB/ARPC3/RAC1/RPS27A/ACTG1/U2AF1/MYL9/ACTR3/ACTN1/VDAC1/TLN1/ARPC1A/MAPK13/ACTN4/CAPN1/RPS6KB2/UBE2N/HK2/RIPK2/CTTN/PLCB3	1.17357612176826
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/709	69/9376	1.53324748063204	CALM3/CALM1/GNAS/REN/NPR1/GNAI1/CALM2/PLCB3	1.27151901192669
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/709	70/9376	1.51134394519444	EGLN3/RAC1/MAP2K2/SLC2A1/GRB2/FH/PAK4/EGLN1	1.22816006376461
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/709	70/9376	1.51134394519444	HLA-C/HLA-G/ACTB/RAC1/ACTG1/CAV1/CD55/RAC3	1.22816006376461
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/709	28/9376	1.88917993149305	CBR1/DHFR/GGH/PCBD2	1.34767034993635
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/709	93/9376	1.42196338929584	ACTB/RAC1/ACTG1/ACP1/MYL9/ACTN1/RAC3/CDH1/CDH5/ACTN4	1.16962442389927
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/709	140/9376	1.32242595204513	CALM3/CALM1/MYL3/GNG11/MAP2K2/CDH1/ACTA2/SLC8A1/MYL4/RPS6KB2/GNAI1/CALM2/GNB2/PLCB3	1.0993257584525
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/709	30/9376	1.76323460272685	ABCG2/TYMS/DHFR/GGH	1.19751275600917
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/709	63/9376	1.46936216893904	RPA3/POLR2I/POLD2/POLR2H/POLR2F/POLR2E/RAD23A	1.06907435762011
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/709	31/9376	1.70635606715501	MDH2/MDH1/ACAT2/ACAT1	1.12665054572951
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/709	98/9376	1.34941423678075	CALM3/CALM1/IMPA2/ITPKB/PTEN/SYNJ1/DGKZ/CALM2/PIK3C2B/PLCB3	0.994490886185984
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/709	42/9376	1.57431660957754	ACAT2/ALDH2/MAOA/ACAT1/ALDH7A1	1.06688222846411
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/709	87/9376	1.36802684694324	RALB/RAC1/BIRC5/RAC3/MAP2K2/MYC/RALA/GRB2/RPS6KB2	0.986345354026173
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	16/709	170/9376	1.24463619016013	GSTP1/MGST1/ACTB/ACTG1/PTEN/MGST3/MAP2K2/MYC/SMARCA2/GRB2/GSTA4/RPS6KB2/WNT3A/WNT10B/NQO1/WNT2	0.920627699320051
Genetic Information Processing	Transcription	hsa03040	Spliceosome	22/709	243/9376	1.19725806357996	SRSF9/SNRPD2/U2AF1/SNRPF/ALYREF/SNRPB/LSM2/LSM5/SNRPG/RBM8A/SNRPD3/LSM4/SNRPA1/HNRNPA3/EIF4A3/TXNL4A/THOC7/SNRPD1/MAGOH/BCAS2/CWC15/LSM6	0.891057091640083
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/709	32/9376	1.65303244005642	PFKP/PFKM/HK2/GALK1	1.05832166724284
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/709	12/9376	2.20404325340856	VKORC1/NQO1	1.19364825254025
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/709	89/9376	1.33728467060744	COL1A1/COL1A2/COL6A2/SDC1/COL6A3/CD47/LAMA4/HMMR/TNXB	0.914383206554781
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/709	22/9376	1.80330811642518	ALDH2/MAOA/ALDH7A1	1.07887013223101
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/709	101/9376	1.30933262578726	CALM3/CALM1/GNAS/MAP2K2/GNAI1/CALM2/WNT3A/WNT10B/PLCB3/WNT2	0.893930619725393
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/709	101/9376	1.30933262578726	COL1A1/COL3A1/RAC1/MMP2/COL1A2/PRKCZ/VEGFB/MAPK13/STAT5B/PLCB3	0.893930619725393
Organismal Systems	Immune system	hsa04611	Platelet activation	12/709	126/9376	1.25945328766203	COL1A1/GNAS/COL3A1/ACTB/ACTG1/PPP1CA/COL1A2/PRKCZ/TLN1/MAPK13/GNAI1/PLCB3	0.838586645398742
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/709	138/9376	1.24576357801353	CALM3/CALM1/PYGL/EIF4EBP1/PPP1CA/PRKCZ/SOCS3/MAP2K2/GRB2/RPS6KB2/CALM2/HK2/GYS1	0.831845062089363
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/709	56/9376	1.41688494861979	OSTC/TUSC3/DAD1/ALG9/SRD5A3/ALG3	0.89490437302668
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/709	23/9376	1.72490341571104	GPT2/GLS/ARG2	0.995503874127674
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/709	23/9376	1.72490341571104	ACAT2/FDPS/ACAT1	0.995503874127674
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/709	23/9376	1.72490341571104	ATP1B3/MDH1/GLS	0.995503874127674
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/709	103/9376	1.28390869130596	COL1A1/GNAS/COL3A1/IL1R2/COL1A2/ACTN1/LAMA4/ACTN4/ARG2/PLCB3	0.828631669837639
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/709	68/9376	1.36132083298764	EIF4EBP1/MAP2K2/CCNA2/MYC/STAT5B/GRB2/RPS6KB2	0.855251076177012
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/709	13/9376	2.03450146468482	XRCC6/XRCC5	1.06750429701611
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	20/709	227/9376	1.16513299739659	HLA-C/CALM3/HLA-G/CALM1/CALR/GNAS/EIF4EBP1/RAC1/PDIA3/GNG11/RAC3/MAP2K2/MYC/MAPK13/GRB2/RPS6KB2/GNAI1/CALM2/GNB2/PLCB3	0.720334700332161
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/709	154/9376	1.20220541095012	CALM3/CALM1/GNAS/ACTB/ACTG1/MYL6/PPP1CA/MYL6B/MYL9/MAP2K2/NPR1/GNAI1/CALM2/PLCB3	0.723627281706972
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	18/709	205/9376	1.16115449447865	HLA-C/HLA-G/PKM/RANBP1/RAC1/CHEK1/CDC20/ACTN1/CCND3/CDK1/CCNA2/SKP2/VDAC3/STAT5B/GRB2/GTF2A2/ACTN4/IRF7	0.667245054379882
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/709	71/9376	1.3038002344107	CGA/SOCS3/MAP2K2/MAPK13/STAT5B/GRB2/LHB	0.734908799982418
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/709	48/9376	1.37752703338035	HSD17B10/ACAT2/ALDH2/ACAT1/ALDH7A1	0.749978412667164
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/709	108/9376	1.22446847411586	RAN/KPNA2/ALYREF/RBM8A/EIF4A3/THOC7/MAGOH/NUP37/SEC13/KPNB1	0.671040259968525
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/709	109/9376	1.21323481839003	PYGL/PPP1CA/PTEN/PRKCZ/SOCS3/SLC2A1/RPS6KB2/SLC27A2/GYS1/SLC27A6	0.640436603459269
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/709	15/9376	1.76323460272685	ST3GAL1/HEXB	0.84609068970385
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/709	98/9376	1.21447281310267	ARPC3/RAC1/MYO10/CFL1/ACTR3/NCF1/ARPC1A/RPS6KB2/CFL2	0.61042520742827
NA	NA	hsa04517	IgSF CAM signaling	25/709	299/9376	1.10570731776349	TUBA1B/TUBA1C/TUBB/ACTB/TUBB6/ARPC3/RAC1/DYNLL1/JAM3/ACTG1/TUBB4B/MYL6/MYL6B/MYL9/ACTR3/ACTN1/MAP2K2/CDH1/SPTBN1/ARPC1A/MAPK13/GRB2/APP/ACTN4/PAK4	0.53130491933787
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/709	75/9376	1.23426422190879	CGA/GNAS/HSPA5/ATP1B3/HSP90B1/PDIA4/PLCB3	0.582567339217379
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/709	137/9376	1.15832930106143	TUBA1B/TUBA1C/ACTB/ACTG1/BIRC5/LMNB2/MAP2K2/DFFA/LMNB1/CAPN1/EIF2S1/CTSZ	0.533928928955307
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/709	16/9376	1.65303244005642	MIF/MAOA	0.747706541680324
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/709	16/9376	1.65303244005642	ST3GAL1/HEXB	0.747706541680324
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/709	125/9376	1.16373483779972	RAC1/ORMDL2/PTEN/PRKCZ/RAC3/MAP2K2/MAPK13/CERS5/DEGS1/GNAI1/PLCB3	0.52707949049596
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/709	88/9376	1.20220541095012	PROCR/TFPI/PLAUR/CD55/C1R/C1S/CFD/PROS1	0.545063829570348
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/709	226/9376	1.11177403048042	CALM3/CGA/CALM1/GNAS/RAC1/ATP1B3/PPP1CA/MYL9/PDE4D/RAC3/MAP2K2/ATP2B4/HCAR3/NPR1/GNAI1/HCAR2/CALM2/ATP2B1/LHB	0.486473224373294
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/709	28/9376	1.41688494861979	ACOT4/ELOVL2/ELOVL6	0.631844539773014
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/709	139/9376	1.14166269241307	CALM3/CALM1/GNAS/KRT18/MMP2/MAP2K2/HSP90B1/GRB2/GNAI1/CALM2/KRT23/PLCB3	0.481251146864974
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/709	41/9376	1.29017166053184	MMP2/MAP2K2/MYC/CDH1	0.532554574794051
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/709	78/9376	1.18679252106615	TPI1/IMPA2/ITPKB/PTEN/SYNJ1/PIK3C2B/PLCB3	0.473790525273145
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/709	103/9376	1.15551782217536	PPP1CA/ALYREF/SSU72/RBM8A/EIF4A3/PABPC4/PAPOLA/MAGOH/PELO	0.453902950578598
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/709	29/9376	1.36802684694324	CALM3/CALM1/CALM2	0.567697178822722
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/709	79/9376	1.17176983092607	GSTP1/MGST1/CBR1/ADH5/MGST3/GSTA4/AKR7A2	0.438493717943065
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/709	67/9376	1.18426204660758	CALM3/CALM1/PPP1CA/MAP2K2/CALM2/PLCB3	0.432908521113862
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/709	18/9376	1.46936216893904	HEXB/FUCA1	0.570068667582968
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/709	93/9376	1.13757071143667	CALM3/CALM1/GNAS/ATP1B3/ATP2B4/CALM2/PLCB3/ATP2B1	0.381327072896174
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/709	157/9376	1.09500238067431	CALR/ODC1/RAC1/SLC16A1/MAP2K2/CPT1C/CD47/SLC2A1/MAPK13/ATP11B/ARG2/DUSP5/PROS1	0.343333961583665
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/709	157/9376	1.09500238067431	ACTB/ACTG1/BIRC5/PPP1CA/CCND3/PRKCZ/MYC/CDH1/BMP7/WNT3A/WNT10B/TEAD4/WNT2	0.343333961583665
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/709	43/9376	1.23016367632105	AGPAT2/PLA2G2A/ACAT2/ACAT1	0.432648037563796
NA	NA	hsa04981	Folate transport and metabolism	3/709	31/9376	1.27976705036626	ABCG2/TYMS/DHFR	0.446233443200692
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/709	69/9376	1.14993561047403	CALM3/CALM1/GNAS/PPP1CA/MAOA/CALM2	0.357518762313882
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	11/709	133/9376	1.09373574981176	CALM3/CALM1/GNAS/PPP1CA/GNG11/MAPK13/MAOA/GNAI1/CALM2/GNB2/PLCB3	0.311385911488447
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/709	82/9376	1.12890020296536	HLA-C/HLA-G/CALR/HSPA2/PDIA3/HSPA5/PSME2	0.335299997986546
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/709	44/9376	1.20220541095012	GNAS/RAB11A/DYNLL1/AQP2	0.384508640648623
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/709	173/9376	1.07017129067236	ACTB/RAB11A/ACTG1/KPNA2/SLC25A5/CCND3/SOCS3/MAP2K2/SLC25A6/VDAC1/DNAJC3/FDPS/EIF2S1/IRF7	0.266435544628739
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/709	122/9376	1.08395569839765	LEP/EIF4EBP1/SCD/CAB39L/CCNA2/CPT1C/PFKP/PFKM/RPS6KB2/GYS1	0.26695601084633
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/709	97/9376	1.0906605790063	CALM3/CALM1/GNAS/GNG11/GNAI1/CALM2/GNB2/PLCB3	0.256701334041784
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/709	33/9376	1.20220541095012	GPT2/IDH2/PDHA1	0.332798167316242
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/709	46/9376	1.14993561047403	ALAS2/FTH1/BLVRB/ALAD	0.291552818195314
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/709	59/9376	1.12069995936028	PTEN/MAP2K2/MYC/CDH1/GRB2	0.265992529486221
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/709	99/9376	1.06862703195566	CALM3/CALM1/GNAS/PPP1CA/MAPK13/TRPV2/CALM2/PLCB3	0.19632852014736
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	17/709	217/9376	1.03600189791554	MGST1/GNAS/EIF4EBP1/KPNA2/BIRC5/CCND3/MGST3/MAP2K2/MYC/HSP90B1/STAT5B/GRB2/GSTA4/RPS6KB2/GNAI1/CDC6/KPNB1	0.153463673934703
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/709	86/9376	1.07639321678092	EIF4EBP1/MAP2K2/MYC/STAT5B/GRB2/RPS6KB2/PAK4	0.203549726842761
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/709	73/9376	1.0869254400371	GSTP1/MGST1/ADH5/MGST3/MAOA/GSTA4	0.213241228051917
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/709	21/9376	1.25945328766203	CHSY1/DSEL	0.340424875407211
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/709	47/9376	1.12546889535756	PKM/PRKCZ/SOCS3/HK2	0.246627678176205
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/709	232/9376	1.02602013520743	PFN1/ACTB/ARPC3/RAC1/ACTG1/PPP1CA/MYL9/CFL1/ACTR3/ACTN1/RAC3/MAP2K2/ENAH/ARPC1A/ACTN4/DIAPH3/CFL2/PAK4	0.114778300567661
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/709	75/9376	1.05794076163611	GSTP1/MGST1/BIRC5/MGST3/TOP2A/GSTA4	0.144086856556855
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/709	102/9376	1.03719682513344	GNAS/RAB11A/RAC1/ATP1B3/PLA2G2A/ATP2B4/PLCB3/ATP2B1	0.108030595648528
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/709	195/9376	1.01725073234241	CYBA/CASP4/ACTB/RAC1/HMGB1/ACTG1/VDAC2/SLC25A5/MAP2K2/NCF1/SLC25A6/VDAC1/VDAC3/MAPK13/PLCB3	0.0696232362323703
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/709	76/9376	1.04402048845668	DBI/SCD/CPT1C/ACSL4/SLC27A2/SLC27A6	0.110203284036831
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/709	76/9376	1.04402048845668	CALM3/CALM1/PTEN/MAP2K2/GRB2/CALM2	0.110203284036831
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/709	63/9376	1.04954440638503	ACAT2/ALDH2/SMYD2/ACAT1/ALDH7A1	0.11284815422911
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/709	250/9376	1.0050437235543	HLA-C/HLA-G/RAB11A/ARPC3/ACTR3/CAV1/CLTA/ARF5/VPS29/SNX6/CHMP4A/PRKCZ/SNF8/CAPZB/VPS28/ARPC1A/AP2S1/SNX2/CHMP2A	0.0231182738850732
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/709	184/9376	1.00619365916478	RAC1/MYL9/FES/CFL1/PRKCZ/RAC3/ENAH/EPHB4/EPHA2/BMP7/GNAI1/CFL2/SEMA6A/PAK4	0.0242675293616606
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/709	77/9376	1.03046178081439	RALBP1/RALB/RAC1/RAC3/RALA/RPS6KB2	0.0767638742099447
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/709	37/9376	1.07223725841497	ADH5/MIF/MAOA	0.1259175563621
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/709	37/9376	1.07223725841497	MAP2K2/MYC/CDH1	0.1259175563621
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/709	105/9376	1.00756263012963	GNAS/TPM2/ACTB/TPM4/ACTG1/MYL3/SLC8A1/TNNC1	0.0222883837756552
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/709	10/9376	1.32242595204513	SELENBP1	0.291761022052758
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	25/709	333/9376	0.992812276310161	HLA-C/HLA-G/PKM/COL1A1/GNAS/ATP6V1F/EIF4EBP1/ISG15/ATP6V1B1/PTEN/COL1A2/COL6A2/CCND3/PRKCZ/MAP2K2/COL6A3/CCNA2/LAMA4/GRB2/TUBG1/RPS6KB2/TNXB/WNT3A/WNT10B/WNT2	-0.0381972047343607
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/709	65/9376	1.01725073234241	AGPAT2/AGPAT5/ALDH2/ALDH7A1/DGKZ	0.0399153929743976
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/709	65/9376	1.01725073234241	CGA/MAP2K2/KISS1R/PLCB3/LHB	0.0399153929743976
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/709	106/9376	0.998057322298214	GSTP1/IL1R2/PTEN/MAP2K2/HSP90B1/MMP3/ETV5/GRB2	-0.00575291792862892
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/709	38/9376	1.04402048845668	NNMT/PNP/NT5C	0.0777667730622687
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/709	52/9376	1.01725073234241	VDAC2/LRPAP1/VDAC1/VDAC3	0.0356765157622355
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/709	66/9376	1.00183784245843	HSD3B1/CYP11A1/SRD5A3/HSD17B1/STS	0.00428528553887389
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/709	216/9376	0.979574779292692	CYBA/CALM3/CALM1/RAC1/HSPA2/HSPA5/HSPD1/NCF1/HSP90B1/MMP3/MIB2/MAPK13/CALM2/EIF2S1/IRF7/PLCB3	-0.0868600858568579
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/709	122/9376	0.975560128557886	ACTB/ACTG1/ATP1B3/MAP2K2/MYC/PFKP/SLC2A1/PFKM/PLCB3	-0.0777120637467831
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/709	178/9376	0.965816706549817	RAC1/LGR4/CCND3/RAC3/DKK1/MYC/RUVBL1/RSPO3/WNT3A/WNT10B/FRZB/PLCB3/WNT2	-0.131689624499565
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/709	69/9376	0.958279675395025	RAC1/RAC3/MAP2K2/MAPK13/GRB2	-0.0994813624925197
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/709	41/9376	0.967628745398878	SSBP1/RPA3/POLD2	-0.0594112453919625
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/709	27/9376	0.979574779292692	ACAT2/ACAT1	-0.0303976785255679
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/709	70/9376	0.944589965746524	LEP/SOCS3/CPT1C/SLC2A1/ACSL4	-0.133085356424961
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/709	70/9376	0.944589965746524	GSTP1/MGST1/CBR1/MGST3/GSTA4	-0.133085356424961
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/709	56/9376	0.944589965746524	BNIP3/HSPD1/VCP/SAR1A	-0.118945723819399
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/709	168/9376	0.944589965746524	PYGL/HMGB1/VDAC2/SLC25A5/CHMP4A/SLC25A6/FTH1/VDAC1/VDAC3/STAT5B/CAPN1/CHMP2A	-0.207269195485424
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/709	99/9376	0.935048652961206	EIF4EBP1/RAC1/RAC3/MAP2K2/GRB2/RPS6KB2/DGKZ	-0.185813104287277
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/709	99/9376	0.935048652961206	TPM2/ACTB/TPM4/ACTG1/MYL3/SLC8A1/TNNC1	-0.185813104287277
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/709	71/9376	0.931285881721925	ATP6V1F/RAC1/JAM3/ATP6V1B1/MAPK13	-0.166223078476374
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	11/709	155/9376	0.938495836935256	GNAS/HSD3B1/CYP11A1/MAP2K2/WDR5/GNAI1/FH/WNT3A/WNT10B/PLCB3/WNT2	-0.220828798069889
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/709	238/9376	0.944589965746524	CALM3/CALM1/RALBP1/RALB/RAC1/ANGPT4/GNG11/PLA2G2A/RAC3/MAP2K2/VEGFB/RALA/EPHA2/GRB2/CALM2/GNB2/PAK4	-0.247642784059456
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/709	28/9376	0.944589965746524	ATP6V1F/ATP6V1B1	-0.0839812703903231
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/709	254/9376	0.937152249480804	CALM3/CALM1/GNAS/VDAC2/ITPKB/SLC25A5/ATP2B4/VEGFB/SLC25A6/VDAC1/VDAC3/SLC8A1/MST1/TNNC1/CALM2/TACR3/PLCB3/ATP2B1	-0.290426285053905
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/709	44/9376	0.901654058212591	TAF10/TAF9/GTF2A2	-0.187012128964803
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/709	44/9376	0.901654058212591	HLA-C/HLA-G/HSPD1	-0.187012128964803
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/709	59/9376	0.896559967488226	CGA/GNAS/NPR1/GNAI1	-0.227955966545232
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	13/709	187/9376	0.919333549550093	CYBA/CASP4/VDAC2/SUGT1/TRIP6/TXN2/VDAC1/VDAC3/MAPK13/TRPV2/RIPK2/IRF7/PLCB3	-0.318679393678356
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/709	14/9376	0.944589965746524	ST3GAL1	-0.059339307755134
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/709	60/9376	0.881617301363423	RAC1/RAC3/MAP2K2/MAPK13	-0.263101593620741
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/709	60/9376	0.881617301363423	GNAS/MAP2K2/GNAI1/PLCB3	-0.263101593620741
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/709	133/9376	0.894874704391444	BNIP3/PTEN/MAP2K2/SKP2/CCNB2/MAPK13/GRB2/CCNB1/PLK1	-0.349221466295392
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/709	31/9376	0.853178033577506	ALDH2/ALDH7A1	-0.234183659328124
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/709	31/9376	0.853178033577506	ALDH2/ALDH7A1	-0.234183659328124
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/709	91/9376	0.871929199150638	RAC1/CD81/IFITM1/RAC3/MAP2K2/GRB2	-0.351118914246499
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	8/709	120/9376	0.881617301363423	CALM3/CALM1/RAC1/MAP2K2/MAPK13/GRB2/CALM2/RIPK2	-0.373285863599773
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/709	32/9376	0.826516220028209	LDHA/LDHB	-0.28115240836041
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	17/709	250/9376	0.899249647390691	ATP6V1F/LAPTM4B/CD63/ATP6V1B1/CLTA/VPS29/HYAL3/IDUA/HEXB/LAMTOR2/CTSE/FUCA1/AP2S1/ACP5/LAMTOR1/CTSZ/AP5B1	-0.461796571632697
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/709	122/9376	0.867164558718121	GNAS/SOCS3/MAP2K2/MAPK13/STAT5B/GRB2/GNAI1/PLCB3	-0.422380138339896
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/709	48/9376	0.826516220028209	ATP1B3/HK2/PLCB3	-0.344635160989021
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	12/709	180/9376	0.881617301363423	HLA-C/HLA-G/CALR/SRSF9/EIF4EBP1/PDIA3/PPP1CA/ALYREF/SOCS3/EIF2B2/EIF2S1/IRF7	-0.458668974769707
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	9/709	138/9376	0.862451707855522	ACTB/ARPC3/RAC1/ACTG1/ACTR3/RAC3/MAP2K2/ARPC1A/MAPK13	-0.465564786059995
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/709	49/9376	0.809648542068449	GNAS/MAOA/GNAI1	-0.38208291339401
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/709	196/9376	0.877119253907487	HLA-C/CALM3/HLA-G/CALM1/RAC1/RPS27A/GNG11/MAP2K2/MYC/MAPK13/CALM2/GNB2/IRF7	-0.497238665459364
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/709	80/9376	0.826516220028209	EIF4EBP1/PTEN/MAP2K2/GRB2/RPS6KB2	-0.445687208495154
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/709	65/9376	0.813800585873929	GNAS/HSD3B1/CYP11A1/PLCB3	-0.430835203916106
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/709	17/9376	0.777897618850079	SEPHS1	-0.262142422916279
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/709	34/9376	0.777897618850079	BHLHE40/NPAS2	-0.371062528118562
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/709	169/9376	0.860750619674348	BNIP3/RPS27A/HMGB1/PTEN/MAP2K2/WDR45/NRBF2/RPS6KB2/YKT6/TAX1BP1/EIF2S1	-0.522458632600494
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/709	18/9376	0.734681084469519	ACSL4	-0.322245827785631
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/709	83/9376	0.796642139786225	IDH2/ACSL4/PECR/ECI2/SLC27A2	-0.532226382298136
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/709	83/9376	0.796642139786225	POLR1D/POLR2H/POLR2F/POLR2E/IRF7	-0.532226382298136
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/709	36/9376	0.734681084469519	GALNT2/ST3GAL1	-0.456163343581746
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/709	99/9376	0.801470273966748	GNAS/MMP2/MAP2K2/MAPK13/GRB2/RPS6KB2	-0.567954728721914
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/709	19/9376	0.696013658971123	PDHA1	-0.37934722652543
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/709	115/9376	0.804954927331821	GNAS/GNG11/MAOA/APP/GNAI1/GNB2/PLCB3	-0.601906895949802
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/709	115/9376	0.804954927331821	NACA/GNAS/PDE4D/MMP15/GNAI1/OXSR1/PLCB3	-0.601906895949802
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/709	100/9376	0.79345557122708	GYPA/CD9/IL1R2/CD55/CD7/ANPEP	-0.593891996422798
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/709	54/9376	0.734681084469519	RPA3/UBE2T/RMI2	-0.559222841136601
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/709	54/9376	0.734681084469519	HLA-C/HLA-G/CGA	-0.559222841136601
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/709	20/9376	0.661212976022567	EBP	-0.433781490472631
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/709	20/9376	0.661212976022567	GMPPA	-0.433781490472631
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/709	38/9376	0.696013658971123	ATP1B3/SFN	-0.537023500320389
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/709	55/9376	0.721323246570073	HEXB/CERS5/DEGS1	-0.592823199090537
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	12/709	193/9376	0.822233752566923	RAC1/CXCL14/GNG11/PRKCZ/RAC3/NCF1/CCR7/STAT5B/GRB2/GNAI1/GNB2/PLCB3	-0.713690678700793
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/709	149/9376	0.798780776403101	GNAS/RALB/AGPAT2/MAP2K2/AGPAT5/RALA/GRB2/DGKZ/PLCB3	-0.708119738577898
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/709	39/9376	0.678167154894941	HLA-C/HLA-G	-0.576014407335478
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/709	21/9376	0.629726643831016	ALDH2	-0.485830271322794
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/709	73/9376	0.724616960024731	RAN/CHMP4A/MAP1B/NELFE	-0.675556173243824
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/709	91/9376	0.726607665958865	GNAS/PDE4D/GNG11/GNAI1/GNB2	-0.749532437177055
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/709	156/9376	0.762938049256808	CLDN10/CLDN6/CD81/SOCS3/MAP2K2/MYC/GRB2/EIF2S1/IRF7	-0.853951193755138
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/709	77/9376	0.686974520542927	MAP2K2/MYC/STAT5B/GRB2	-0.788826125299909
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/709	24/9376	0.551010813352139	HS3ST1	-0.629888400719371
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/709	44/9376	0.601102705475061	HMGB1/POLD2	-0.758532898578228
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/709	143/9376	0.739818714430844	SSB/SNRPB/ACTN1/SNRPD3/C1R/SNRPD1/C1S/ACTN4	-0.896699677762886
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/709	79/9376	0.669582760529182	ATP6V1F/ATP6V1B1/CLTA/AP2S1	-0.843488539442086
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/709	144/9376	0.734681084469519	LIFR/MAP2K2/MYC/MAPK13/GRB2/WNT3A/WNT10B/WNT2	-0.917647570501626
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/709	160/9376	0.743864598025388	HLA-C/HLA-G/JAM3/CLDN10/CLDN6/SDC1/VCAN/CDH1/CDH5	-0.934614952428133
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/709	45/9376	0.587744867575615	ABCG2/ABCA7	-0.792834592615768
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/709	45/9376	0.587744867575615	HLA-C/HLA-G	-0.792834592615768
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/709	63/9376	0.629726643831016	CBR1/PTGDS/PLA2G2A	-0.843378049161885
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/709	63/9376	0.629726643831016	WNT3A/WNT10B/WNT2	-0.843378049161885
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/709	26/9376	0.508625366171205	PLA2G2A	-0.717576089813982
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/709	163/9376	0.730173838552528	BIRC5/MAP2K2/CCNA2/MYC/VDAC3/MAPK13/STAT5B/GRB2/IRF7	-0.993920571102833
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/709	99/9376	0.66789189497229	KRT18/C1R/C1S/CFD/KRT23	-0.95009635315655
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/709	148/9376	0.714824838943316	PTEN/MAP2K2/MYC/GRB2/RPS6KB2/WNT3A/WNT10B/WNT2	-1.00014534461099
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/709	116/9376	0.684013423471621	GNAS/GNG11/GLS/GNAI1/GNB2/PLCB3	-0.979414416802724
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/709	117/9376	0.678167154894941	ACTB/ACTG1/SMARCA2/RUVBL1/TFPT/RUVBL2	-1.00187977805993
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/709	150/9376	0.705293841090738	MAP2K2/MYC/CDH1/GRB2/RPS6KB2/WNT3A/WNT10B/WNT2	-1.04064469336465
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/709	28/9376	0.472294982873262	ST3GAL4	-0.79980708055366
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/709	29/9376	0.456008948981081	TEAD4	-0.83912950246229
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/709	103/9376	0.641954345652978	CALR/GNAS/MAPK13/GNAI1/PLCB3	-1.04501192645757
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/709	86/9376	0.615081838160527	GNAS/ATP1B3/SLC2A1/PLCB3	-1.02561444589944
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/709	30/9376	0.440808650681711	PLA2G2A	-0.877369515829316
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/709	51/9376	0.518598412566719	PLA2G2A/PAFAH1B3	-0.985921967597027
NA	NA	hsa04081	Hormone signaling	12/709	219/9376	0.724616960024731	LEP/CGA/GNAS/GNG11/GAST/STAT5B/NPR1/GNAI1/GNB2/SLC40A1/PLCB3/LHB	-1.17938879582732
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/709	89/9376	0.594348742492195	GNG11/GLS/GNAI1/GNB2	-1.09972592859008
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/709	90/9376	0.587744867575615	ABCG2/GNAS/ATP1B3/SLC2A1	-1.12395091114554
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/709	90/9376	0.587744867575615	PTEN/MAP2K2/MAPK13/RPS6KB2	-1.12395091114554
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/709	72/9376	0.551010813352139	ISG15/MAPK13/IRF7	-1.09380936283346
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/709	32/9376	0.413258110014104	BIRC5	-0.950889446162037
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/709	142/9376	0.651900117205348	CYBA/RAC1/SOCS3/NCF1/MAPK13/GRB2/ACP5	-1.19543914175727
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/709	191/9376	0.692369608400594	CALM3/CALM1/GNAS/PPP1CA/GNG11/MAOA/GRB2/GNAI1/CALM2/GNB2	-1.22851566647894
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/709	73/9376	0.543462720018548	PTEN/MAP2K2/CDH1	-1.11995487389169
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/709	73/9376	0.543462720018548	MAP2K2/STAT5B/GRB2	-1.11995487389169
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	21/709	362/9376	0.767153176600768	COL1A1/EIF4EBP1/RAC1/ANGPT4/PTEN/COL1A2/COL6A2/CCND3/GNG11/MAP2K2/COL6A3/VEGFB/MYC/HSP90B1/LAMA4/EPHA2/GRB2/RPS6KB2/TNXB/GNB2/GYS1	-1.2922310834111
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/709	33/9376	0.400735136983374	YKT6	-0.986295308378995
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/709	110/9376	0.601102705475061	LRRC32/DCN/MYC/RPS6KB2/BMP7	-1.20360959973463
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/709	93/9376	0.568785355718337	PTEN/MYC/LAMA4/SKP2	-1.19526762911001
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/709	95/9376	0.556810927176899	ATP6V1F/ATP6V1B1/MMP3/ACP5	-1.24173184150087
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/709	78/9376	0.508625366171205	CYBA/NCF1/MAPK13	-1.24634886096539
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/709	133/9376	0.596583136260963	HLA-C/HLA-G/RAC1/RAC3/MAP2K2/GRB2	-1.34013253297115
NA	NA	hsa04519	Cadherin signaling	23/709	404/9376	0.752866259827675	ACTB/KRT18/MYO1B/ARPC3/RAC1/ACTG1/PPP1CA/ACTR3/ACTN1/RAC3/MAP2K2/CDH1/ENAH/ARPC1A/MAPK13/CDH5/ACTN4/KRT23/WNT3A/WNT10B/PCDH10/TEAD4/WNT2	-1.45228699898857
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/709	38/9376	0.348006829485562	ADA	-1.15181377370305
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/709	104/9376	0.508625366171205	AGPAT2/PLA2G2A/AGPAT5/DGKZ	-1.44117609191509
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/709	105/9376	0.503781315064813	CALM3/CALM1/MAPK13/CALM2	-1.46244260223177
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/709	86/9376	0.461311378620396	ACTB/ACTG1/SLC8A1	-1.43533583681351
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/709	144/9376	0.551010813352139	ADH5/SCD/CPT1C/ALDH2/MAPK13/ALDH7A1	-1.55290034819088
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/709	109/9376	0.485293927356013	RAC1/MAP2K2/MAPK13/IRF7	-1.5458854770192
NA	NA	hsa04382	Cornified envelope formation	10/709	217/9376	0.60941288112679	S100A10/KRT18/CLDN10/PADI1/CLDN6/S100A6/TCHH/CAPN1/KRT23/S100A16	-1.66493817616142
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/709	183/9376	0.57810970581208	RAN/RRP7A/POP7/FBL/IMP4/EMG1/NOP56/NHP2	-1.64843112703426
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/709	201/9376	0.592131023303791	IL1R2/CCNA2/MYC/MYCN/MMP3/ETV5/ETV4/TLX3/AFF1	-1.67182195037971
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/709	168/9376	0.551010813352139	LEP/LIFR/CCND3/SOCS3/MYC/STAT5B/GRB2	-1.6795085719031
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/709	94/9376	0.422050835759085	HSP90B1/MMP3/MAPK13	-1.61067212372774
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/709	115/9376	0.459974244189612	GNG11/GNAI1/GNB2/PLCB3	-1.66651339593572
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/709	49/9376	0.26988284735615	GALNT2	-1.46552746079526
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/709	136/9376	0.486186011781299	EIF3H/CCND3/STAT5B/EIF2S1/IRF7	-1.72628997916436
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/709	122/9376	0.43358227935906	MAP2K2/MAPK13/GRB2/PAK4	-1.80105243671235
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/709	83/9376	0.31865685591449	AURKB/WDR5	-1.78320521419268
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/709	62/9376	0.213294508394376	RPS6KB2	-1.77751906389965
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/709	112/9376	0.354221237154947	LAMA4/MAPK13/GNAI1	-1.9663818380144
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/709	90/9376	0.293872433787808	EIF4EBP1/RPS6KB2	-1.92514940144437
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/709	93/9376	0.284392677859169	MAPK13/STAT5B	-1.98356498011311
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	6/709	181/9376	0.438373243771868	CALM3/CALM1/HSPD1/MAPK13/CALM2/RIPK2	-2.18215486044652
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/709	119/9376	0.333384693792891	SOCS3/MMP3/MAPK13	-2.09309040890174
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/709	68/9376	0.19447440471252	ADH5	-1.9066894830316
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/709	300/9376	0.528970380818054	RAC1/ANGPT4/RAC3/MAP2K2/VEGFB/MYC/EPHA2/MAPK13/GRB2/STMN1/DUSP5/MAP4K4	-2.37157005740862
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/709	100/9376	0.264485190409027	CXCL14/CCR7	-2.11487843686534
NA	NA	hsa04082	Neuroactive ligand signaling	6/709	199/9376	0.398721392576422	GNAS/GNG11/GNAI1/TACR3/GNB2/PLCB3	-2.45203284038896
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/709	109/9376	0.242646963678006	MAPK13/STAT5B	-2.27465950384535
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/709	86/9376	0.153770459540132	PLCB3	-2.25477861864165
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/709	323/9376	0.450361779334256	PTEN/MAP2K2/IGF2BP1/MYC/GLS/GRB2/STMN1/KIF23/TNXB/WNT3A/PAK4	-2.87512203756138
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/709	298/9376	0.355013678401378	LEP/LIFR/ACVRL1/IL1R2/CXCL14/CCR7/BMP7/IL36RN	-3.23621901157891
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/709	370/9376	0.321671177524492	LEP/CGA/GAL/NMB/KISS1R/TACR3/TMEM97/NPW/LHB	-3.80758422667897
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/709	449/9376	0.117810775237874	CALM3/CALM1/SLC8A1/CALM2	-5.47906571773427