ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 63/1239 175/18639 0.36 5.41569007263922 3.14879345452305e-30 3.39439934397585e-27 GO:0045296 cadherin binding 69/1239 334/18639 0.206586826347305 3.10780617940874 1.5314358852475e-17 8.25443942148405e-15 GO:0009055 electron transfer activity 36/1239 116/18639 0.310344827586207 4.66869833848209 1.79780145618033e-15 6.46009989920799e-13 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 26/1239 68/18639 0.382352941176471 5.75195841048284 5.51914690301938e-14 1.48741009036372e-11 GO:0022853 active monoatomic ion transmembrane transporter activity 31/1239 118/18639 0.26271186440678 3.95212787786761 2.13125149761038e-11 4.59497822884798e-09 GO:0003954 NADH dehydrogenase activity 18/1239 44/18639 0.409090909090909 6.15419326436276 1.11470839963023e-10 2.00275942466898e-08 GO:0008137 NADH dehydrogenase (ubiquinone) activity 17/1239 41/18639 0.414634146341463 6.2375834169964 2.85368369541263e-10 4.39467289093546e-08 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 20/1239 58/18639 0.344827586206897 5.18744259831343 3.95120572599861e-10 5.32424971578312e-08 GO:0015399 primary active transmembrane transporter activity 35/1239 166/18639 0.210843373493976 3.1718399019808 8.19163901984369e-10 9.8117631815461e-08 GO:0016651 oxidoreductase activity, acting on NAD(P)H 23/1239 88/18639 0.261363636363636 3.93184569667621 9.05719432913666e-09 9.76365548680932e-07 GO:0031720 haptoglobin binding 8/1239 10/18639 0.8 12.0348668280872 1.48822045039249e-08 1.45845604138464e-06 GO:0044183 protein folding chaperone 20/1239 75/18639 0.266666666666667 4.01162227602906 5.78681467555689e-08 5.19848851687527e-06 GO:0051082 unfolded protein binding 26/1239 121/18639 0.214876033057851 3.23250555299862 8.00693074571198e-08 6.63959334144424e-06 GO:0015078 proton transmembrane transporter activity 33/1239 185/18639 0.178378378378378 2.68345003599241 1.77456357836305e-07 1.36641395533955e-05 GO:0004601 peroxidase activity 16/1239 57/18639 0.280701754385965 4.2227602905569 5.67907973947301e-07 4.08136530610127e-05 GO:0019843 rRNA binding 17/1239 65/18639 0.261538461538462 3.93447569379773 7.64974761838487e-07 4.94670991984796e-05 GO:0005344 oxygen carrier activity 8/1239 14/18639 0.571428571428571 8.59633344863369 7.80093401089196e-07 4.94670991984796e-05 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 16/1239 59/18639 0.271186440677966 4.07961587392785 9.48265607762407e-07 5.67905736204375e-05 GO:0016860 intramolecular oxidoreductase activity 15/1239 53/18639 0.283018867924528 4.25761798163461 1.13829707984078e-06 6.45833816878084e-05 GO:0022804 active transmembrane transporter activity 56/1239 457/18639 0.12253829321663 1.84341505025405 6.80948252971162e-06 0.00035376917692287 GO:0140662 ATP-dependent protein folding chaperone 12/1239 40/18639 0.3 4.51307506053269 6.89160734265332e-06 0.00035376917692287 GO:0015035 protein-disulfide reductase activity 11/1239 34/18639 0.323529411764706 4.86704173194702 7.37925675212871e-06 0.000361583580854307 GO:0043021 ribonucleoprotein complex binding 28/1239 177/18639 0.15819209039548 2.37977592645791 1.60802970847061e-05 0.000753676532926662 GO:0004129 cytochrome-c oxidase activity 7/1239 15/18639 0.466666666666667 7.02033898305085 2.25863562796398e-05 0.00101450383622716 GO:0051117 ATPase binding 17/1239 84/18639 0.202380952380952 3.04453476305777 3.14687206564737e-05 0.00135693123470715 GO:0016675 oxidoreductase activity, acting on a heme group of donors 7/1239 16/18639 0.4375 6.58156779661017 3.78482710634927e-05 0.00156924754640173 GO:0015036 disulfide oxidoreductase activity 11/1239 40/18639 0.275 4.13698547215496 4.12057763552246e-05 0.00164517877447897 GO:0016209 antioxidant activity 17/1239 86/18639 0.197674418604651 2.97373162903317 4.32184753147299e-05 0.0016639112996171 GO:0044389 ubiquitin-like protein ligase binding 41/1239 322/18639 0.127329192546584 1.91548734453251 4.73900894194584e-05 0.00176160401359228 GO:0048029 monosaccharide binding 15/1239 74/18639 0.202702702702703 3.04937504090046 8.88769405764439e-05 0.00319364473138022 GO:0003743 translation initiation factor activity 12/1239 51/18639 0.235294117647059 3.53966671414328 9.9126792317171e-05 0.00344705426186807 GO:0031625 ubiquitin protein ligase binding 38/1239 302/18639 0.125827814569536 1.89290123951702 0.000113590332467248 0.00382657432499041 GO:0051540 metal cluster binding 15/1239 77/18639 0.194805194805195 2.93056822112512 0.000142501503263033 0.00465504910659241 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 12/1239 54/18639 0.222222222222222 3.34301856335755 0.000177994099462392 0.00564345997707231 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 6/1239 15/18639 0.4 6.01743341404358 0.00025311182337978 0.00779584416009723 GO:0019825 oxygen binding 9/1239 34/18639 0.264705882352941 3.98212505341119 0.000283097302987356 0.00847719146167695 GO:0051015 actin filament binding 28/1239 209/18639 0.133971291866029 2.01540832049307 0.000311455006960187 0.00907428371629951 GO:0008135 translation factor activity, RNA binding 15/1239 83/18639 0.180722891566265 2.71871991598355 0.000337906662084698 0.00958587846650802 GO:0016853 isomerase activity 25/1239 180/18639 0.138888888888889 2.08938660209847 0.00036939578171226 0.0102104782739953 GO:0180051 translation factor activity 15/1239 84/18639 0.178571428571429 2.68635420269803 0.000386505233923511 0.0104163160542386 GO:0043022 ribosome binding 18/1239 112/18639 0.160714285714286 2.41771878242823 0.000411199249254512 0.0107965680353018 GO:0010854 adenylate cyclase regulator activity 5/1239 11/18639 0.454545454545455 6.83799251595862 0.000423950280066896 0.0107965680353018 GO:0051536 iron-sulfur cluster binding 14/1239 76/18639 0.184210526315789 2.77118644067797 0.000430660877103876 0.0107965680353018 GO:0055106 ubiquitin-protein transferase regulator activity 9/1239 36/18639 0.25 3.76089588377724 0.00045050419277614 0.0110373527230154 GO:0051087 protein-folding chaperone binding 20/1239 134/18639 0.149253731343284 2.2453109753894 0.000545835122042069 0.0130757835902522 GO:0019838 growth factor binding 20/1239 136/18639 0.147058823529412 2.21229169633955 0.000662163660636988 0.0155176614384059 GO:0048306 calcium-dependent protein binding 14/1239 80/18639 0.175 2.63262711864407 0.000737470319669548 0.0169147447788037 GO:0005201 extracellular matrix structural constituent 23/1239 168/18639 0.136904761904762 2.05953822206849 0.000762206953115728 0.0171178978220574 GO:0098641 cadherin binding involved in cell-cell adhesion 6/1239 18/18639 0.333333333333333 5.01452784503632 0.000789765820580057 0.0173748480527612 GO:0004857 enzyme inhibitor activity 45/1239 416/18639 0.108173076923077 1.62731071894208 0.000874074699764671 0.0188450505269263 GO:0003756 protein disulfide isomerase activity 6/1239 19/18639 0.315789473684211 4.75060532687651 0.0010898138190927 0.022592678788114 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 6/1239 19/18639 0.315789473684211 4.75060532687651 0.0010898138190927 0.022592678788114 GO:0070006 metalloaminopeptidase activity 7/1239 26/18639 0.269230769230769 4.05019556714472 0.00120913567862789 0.0245933634256766 GO:0032036 myosin heavy chain binding 5/1239 14/18639 0.357142857142857 5.37270840539606 0.00155264777097737 0.0309954499465483 GO:0051537 2 iron, 2 sulfur cluster binding 7/1239 28/18639 0.25 3.76089588377724 0.00193665185889482 0.0379583764343385 GO:0019205 nucleobase-containing compound kinase activity 9/1239 44/18639 0.204545454545455 3.07709663218138 0.0021003665429648 0.0404320559520723 GO:0140104 molecular carrier activity 29/1239 249/18639 0.116465863453815 1.75206394585606 0.00232714292945645 0.0440115803149835 GO:0001094 TFIID-class transcription factor complex binding 4/1239 10/18639 0.4 6.01743341404358 0.00294948304080355 0.0527448569999909 GO:0005522 profilin binding 4/1239 10/18639 0.4 6.01743341404358 0.00294948304080355 0.0527448569999909 GO:0008142 oxysterol binding 5/1239 16/18639 0.3125 4.70111985472155 0.00302975474023371 0.0527448569999909 GO:0097027 ubiquitin-protein transferase activator activity 5/1239 16/18639 0.3125 4.70111985472155 0.00302975474023371 0.0527448569999909 GO:0003779 actin binding 45/1239 443/18639 0.101580135440181 1.52812925300204 0.00303356320408111 0.0527448569999909 GO:0016776 phosphotransferase activity, phosphate group as acceptor 8/1239 39/18639 0.205128205128205 3.08586328925312 0.00360104057066339 0.0616178053202402 GO:0004550 nucleoside diphosphate kinase activity 5/1239 17/18639 0.294117647058824 4.42458339267911 0.00405977838783874 0.0683818922201588 GO:0004177 aminopeptidase activity 8/1239 40/18639 0.2 3.00871670702179 0.00424400975074213 0.0696363367441178 GO:0030515 snoRNA binding 7/1239 32/18639 0.21875 3.29078389830508 0.00436276263480437 0.0696363367441178 GO:0005536 D-glucose binding 4/1239 11/18639 0.363636363636364 5.47039401276689 0.00439264461836736 0.0696363367441178 GO:0048407 platelet-derived growth factor binding 4/1239 11/18639 0.363636363636364 5.47039401276689 0.00439264461836736 0.0696363367441178 GO:0061650 ubiquitin-like protein conjugating enzyme activity 8/1239 41/18639 0.195121951219512 2.93533337270419 0.00497178356195112 0.0776751113012073 GO:1990381 ubiquitin-specific protease binding 5/1239 18/18639 0.277777777777778 4.17877320419693 0.00531747552909207 0.0818891231480178 GO:0008017 microtubule binding 30/1239 276/18639 0.108695652173913 1.63517212338141 0.00548309427010099 0.0832503608897024 GO:0000287 magnesium ion binding 26/1239 230/18639 0.11304347826087 1.70057900831666 0.00563589050358697 0.084381805039816 GO:0008198 ferrous iron binding 6/1239 26/18639 0.230769230769231 3.47159620040976 0.00619974173337971 0.0909807737382893 GO:0010853 cyclase activator activity 4/1239 12/18639 0.333333333333333 5.01452784503632 0.00624543344771188 0.0909807737382893 GO:0005525 GTP binding 38/1239 378/18639 0.100529100529101 1.51231792151889 0.00720176992442965 0.102548606564841 GO:0005200 structural constituent of cytoskeleton 15/1239 112/18639 0.133928571428571 2.01476565202352 0.0072297718913988 0.102548606564841 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/1239 44/18639 0.181818181818182 2.73519700638345 0.00773391416940613 0.108274798371686 GO:0010851 cyclase regulator activity 5/1239 20/18639 0.25 3.76089588377724 0.00861312066094437 0.117104655019988 GO:0003925 G protein activity 9/1239 54/18639 0.166666666666667 2.50726392251816 0.00869446124871339 0.117104655019988 GO:0015485 cholesterol binding 9/1239 54/18639 0.166666666666667 2.50726392251816 0.00869446124871339 0.117104655019988 GO:0002020 protease binding 17/1239 136/18639 0.125 1.88044794188862 0.00879914383730891 0.117104655019988 GO:0003725 double-stranded RNA binding 11/1239 75/18639 0.146666666666667 2.20639225181598 0.010385771499672 0.135668017952218 GO:0019001 guanyl nucleotide binding 39/1239 400/18639 0.0975 1.46674939467312 0.0106082177872421 0.135668017952218 GO:0032561 guanyl ribonucleotide binding 39/1239 400/18639 0.0975 1.46674939467312 0.0106082177872421 0.135668017952218 GO:0019200 carbohydrate kinase activity 5/1239 21/18639 0.238095238095238 3.58180560359737 0.0106973854600543 0.135668017952218 GO:1990825 sequence-specific mRNA binding 4/1239 14/18639 0.285714285714286 4.29816672431685 0.01135178016936 0.142293244448489 GO:0016887 ATP hydrolysis activity 40/1239 417/18639 0.0959232613908873 1.4430295956939 0.0125645489686912 0.1556848711293 GO:0008649 rRNA methyltransferase activity 5/1239 22/18639 0.227272727272727 3.41899625797931 0.0131014158563889 0.158689059474013 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/1239 22/18639 0.227272727272727 3.41899625797931 0.0131014158563889 0.158689059474013 GO:0016829 lyase activity 22/1239 200/18639 0.11 1.65479418886199 0.0138732205580732 0.163316648782972 GO:0005506 iron ion binding 18/1239 154/18639 0.116883116883117 1.75834093267507 0.0138977489550225 0.163316648782972 GO:0032934 sterol binding 10/1239 68/18639 0.147058823529412 2.21229169633955 0.013937970026005 0.163316648782972 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/1239 15/18639 0.266666666666667 4.01162227602906 0.0146788217782995 0.170148063193622 GO:0016835 carbon-oxygen lyase activity 11/1239 79/18639 0.139240506329114 2.09467618843289 0.0150733761314989 0.172862760316551 GO:0061134 peptidase regulator activity 24/1239 226/18639 0.106194690265487 1.59754869399387 0.0157025554978883 0.17792521495576 GO:0140102 catalytic activity, acting on a rRNA 5/1239 23/18639 0.217391304347826 3.27034424676282 0.0158449171018116 0.17792521495576 GO:0003688 DNA replication origin binding 4/1239 16/18639 0.25 3.76089588377724 0.0185618441243215 0.204180285367536 GO:0043023 ribosomal large subunit binding 4/1239 16/18639 0.25 3.76089588377724 0.0185618441243215 0.204180285367536 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/1239 24/18639 0.208333333333333 3.1340799031477 0.0189458528811712 0.204236294059025 GO:0048027 mRNA 5'-UTR binding 5/1239 24/18639 0.208333333333333 3.1340799031477 0.0189458528811712 0.204236294059025 GO:0008307 structural constituent of muscle 7/1239 42/18639 0.166666666666667 2.50726392251816 0.0196534435643587 0.209766457053255 GO:0030246 carbohydrate binding 28/1239 280/18639 0.1 1.5043583535109 0.0202497474167398 0.214012036423975 GO:0061135 endopeptidase regulator activity 20/1239 184/18639 0.108695652173913 1.63517212338141 0.0206155229834277 0.215762463845971 GO:0048038 quinone binding 4/1239 17/18639 0.235294117647059 3.53966671414328 0.0230240181970854 0.234149920909982 GO:0051787 misfolded protein binding 4/1239 17/18639 0.235294117647059 3.53966671414328 0.0230240181970854 0.234149920909982 GO:0070492 oligosaccharide binding 4/1239 17/18639 0.235294117647059 3.53966671414328 0.0230240181970854 0.234149920909982 GO:0015631 tubulin binding 36/1239 385/18639 0.0935064935064935 1.40667274614006 0.024341232145173 0.239887278609326 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/1239 10/18639 0.3 4.51307506053269 0.0247008236786968 0.239887278609326 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/1239 10/18639 0.3 4.51307506053269 0.0247008236786968 0.239887278609326 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/1239 10/18639 0.3 4.51307506053269 0.0247008236786968 0.239887278609326 GO:0097177 mitochondrial ribosome binding 3/1239 10/18639 0.3 4.51307506053269 0.0247008236786968 0.239887278609326 GO:0061631 ubiquitin conjugating enzyme activity 6/1239 35/18639 0.171428571428571 2.57890003459011 0.0263108182585464 0.253241625738509 GO:0098632 cell-cell adhesion mediator activity 8/1239 55/18639 0.145454545454545 2.18815760510676 0.0280136064683117 0.263247884853913 GO:0140313 molecular sequestering activity 8/1239 55/18639 0.145454545454545 2.18815760510676 0.0280136064683117 0.263247884853913 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/1239 18/18639 0.222222222222222 3.34301856335755 0.0280830303879407 0.263247884853913 GO:0098631 cell adhesion mediator activity 10/1239 76/18639 0.131578947368421 1.97941888619855 0.0284849074789665 0.264713191916603 GO:0001671 ATPase activator activity 5/1239 27/18639 0.185185185185185 2.78584880279796 0.0305439664745688 0.274307632368294 GO:0008320 protein transmembrane transporter activity 5/1239 27/18639 0.185185185185185 2.78584880279796 0.0305439664745688 0.274307632368294 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 14/1239 122/18639 0.114754098360656 1.72631286468463 0.0318941212031773 0.274307632368294 GO:0008199 ferric iron binding 3/1239 11/18639 0.272727272727273 4.10279550957517 0.0323163908263204 0.274307632368294 GO:0015217 ADP transmembrane transporter activity 3/1239 11/18639 0.272727272727273 4.10279550957517 0.0323163908263204 0.274307632368294 GO:0034511 U3 snoRNA binding 3/1239 11/18639 0.272727272727273 4.10279550957517 0.0323163908263204 0.274307632368294 GO:0047676 arachidonate-CoA ligase activity 3/1239 11/18639 0.272727272727273 4.10279550957517 0.0323163908263204 0.274307632368294 GO:0050786 RAGE receptor binding 3/1239 11/18639 0.272727272727273 4.10279550957517 0.0323163908263204 0.274307632368294 GO:0050998 nitric-oxide synthase binding 3/1239 11/18639 0.272727272727273 4.10279550957517 0.0323163908263204 0.274307632368294 GO:0070990 snRNP binding 3/1239 11/18639 0.272727272727273 4.10279550957517 0.0323163908263204 0.274307632368294 GO:1990948 ubiquitin ligase inhibitor activity 3/1239 11/18639 0.272727272727273 4.10279550957517 0.0323163908263204 0.274307632368294 GO:0019887 protein kinase regulator activity 25/1239 255/18639 0.0980392156862745 1.47486113089304 0.0333286130377893 0.275634886308564 GO:0005520 insulin-like growth factor binding 4/1239 19/18639 0.210526315789474 3.16707021791768 0.0337512105683956 0.275634886308564 GO:0008301 DNA binding, bending 4/1239 19/18639 0.210526315789474 3.16707021791768 0.0337512105683956 0.275634886308564 GO:0030506 ankyrin binding 4/1239 19/18639 0.210526315789474 3.16707021791768 0.0337512105683956 0.275634886308564 GO:0050145 nucleoside monophosphate kinase activity 4/1239 19/18639 0.210526315789474 3.16707021791768 0.0337512105683956 0.275634886308564 GO:0008514 organic anion transmembrane transporter activity 26/1239 269/18639 0.0966542750929368 1.454026661386 0.0354155328421492 0.287052213562683 GO:0008238 exopeptidase activity 12/1239 102/18639 0.117647058823529 1.76983335707164 0.0379831350682066 0.305565817936767 GO:0005178 integrin binding 17/1239 161/18639 0.105590062111801 1.58845291985623 0.0393760200285941 0.314424811783885 GO:0042288 MHC class I protein binding 4/1239 20/18639 0.2 3.00871670702179 0.0400357330452584 0.31734206046168 GO:0008179 adenylate cyclase binding 3/1239 12/18639 0.25 3.76089588377724 0.0410067099525232 0.318023261358417 GO:0017166 vinculin binding 3/1239 12/18639 0.25 3.76089588377724 0.0410067099525232 0.318023261358417 GO:0031543 peptidyl-proline dioxygenase activity 3/1239 12/18639 0.25 3.76089588377724 0.0410067099525232 0.318023261358417 GO:0043178 alcohol binding 11/1239 92/18639 0.119565217391304 1.79868933571955 0.041335292635572 0.318281753293904 GO:0001618 virus receptor activity 10/1239 81/18639 0.123456790123457 1.85723253519864 0.0417616741451659 0.31892831584983 GO:0060590 ATPase regulator activity 7/1239 49/18639 0.142857142857143 2.14908336215842 0.0420109655386603 0.31892831584983 GO:0000217 DNA secondary structure binding 6/1239 39/18639 0.153846153846154 2.31439746693984 0.0423125611007554 0.318971614451849 GO:0140272 exogenous protein binding 10/1239 82/18639 0.121951219512195 1.83458335794012 0.044850934016891 0.335759075487559 GO:0072542 protein phosphatase activator activity 4/1239 21/18639 0.19047619047619 2.8654444828779 0.0469388736535417 0.348966246886331 GO:0019855 calcium channel inhibitor activity 3/1239 13/18639 0.230769230769231 3.47159620040976 0.0507431145216193 0.364673849695371 GO:0030955 potassium ion binding 3/1239 13/18639 0.230769230769231 3.47159620040976 0.0507431145216193 0.364673849695371 GO:0031432 titin binding 3/1239 13/18639 0.230769230769231 3.47159620040976 0.0507431145216193 0.364673849695371 GO:0031994 insulin-like growth factor I binding 3/1239 13/18639 0.230769230769231 3.47159620040976 0.0507431145216193 0.364673849695371 GO:0045159 myosin II binding 3/1239 13/18639 0.230769230769231 3.47159620040976 0.0507431145216193 0.364673849695371 GO:0004860 protein kinase inhibitor activity 10/1239 84/18639 0.119047619047619 1.79090280179869 0.0514849253334769 0.365340034084748 GO:0043539 protein serine/threonine kinase activator activity 9/1239 73/18639 0.123287671232877 1.85468838104083 0.052155843135837 0.365340034084748 GO:0001530 lipopolysaccharide binding 6/1239 41/18639 0.146341463414634 2.20150002952814 0.0521914334406783 0.365340034084748 GO:0015175 neutral L-amino acid transmembrane transporter activity 6/1239 41/18639 0.146341463414634 2.20150002952814 0.0521914334406783 0.365340034084748 GO:0061133 endopeptidase activator activity 4/1239 22/18639 0.181818181818182 2.73519700638345 0.0544583087195756 0.373923928660526 GO:0140035 ubiquitin-like protein reader activity 4/1239 22/18639 0.181818181818182 2.73519700638345 0.0544583087195756 0.373923928660526 GO:0140517 protein-RNA adaptor activity 4/1239 22/18639 0.181818181818182 2.73519700638345 0.0544583087195756 0.373923928660526 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 14/1239 132/18639 0.106060606060606 1.59553158705701 0.0558869168551202 0.381304407403921 GO:0005507 copper ion binding 8/1239 63/18639 0.126984126984127 1.9102963219186 0.0562563566320533 0.381411021694047 GO:0030414 peptidase inhibitor activity 17/1239 169/18639 0.100591715976331 1.5132598822299 0.0575452124498995 0.385766195218406 GO:0042056 chemoattractant activity 6/1239 42/18639 0.142857142857143 2.14908336215842 0.0576144317533982 0.385766195218406 GO:0022884 macromolecule transmembrane transporter activity 5/1239 32/18639 0.15625 2.35055992736077 0.0581162556390376 0.386724219622732 GO:0003697 single-stranded DNA binding 13/1239 121/18639 0.107438016528926 1.61625277649931 0.0586698393903196 0.388012802839046 GO:0005347 ATP transmembrane transporter activity 3/1239 14/18639 0.214285714285714 3.22362504323763 0.0614862057085991 0.401709877296181 GO:0016530 metallochaperone activity 3/1239 14/18639 0.214285714285714 3.22362504323763 0.0614862057085991 0.401709877296181 GO:0004602 glutathione peroxidase activity 4/1239 23/18639 0.173913043478261 2.61627539741025 0.0625874437969997 0.40644135188654 GO:0051287 NAD binding 7/1239 54/18639 0.12962962962963 1.95009416195857 0.065331792551344 0.421722589044005 GO:0019207 kinase regulator activity 26/1239 287/18639 0.0905923344947735 1.36283335161266 0.0673077554113249 0.431891430556001 GO:0016790 thiolester hydrolase activity 6/1239 44/18639 0.136363636363636 2.05139775478759 0.0694348600025991 0.442142777321375 GO:0004866 endopeptidase inhibitor activity 16/1239 161/18639 0.0993788819875776 1.49501451280586 0.0697256698929812 0.442142777321375 GO:0008235 metalloexopeptidase activity 8/1239 66/18639 0.121212121212121 1.8234646709223 0.0703044200777639 0.443205642361576 GO:0005540 hyaluronic acid binding 4/1239 24/18639 0.166666666666667 2.50726392251816 0.0713157619801655 0.445744179226472 GO:0090482 vitamin transmembrane transporter activity 5/1239 34/18639 0.147058823529412 2.21229169633955 0.072123584583257 0.445744179226472 GO:0004467 long-chain fatty acid-CoA ligase activity 3/1239 15/18639 0.2 3.00871670702179 0.0731880516911739 0.445744179226472 GO:0031386 protein tag activity 3/1239 15/18639 0.2 3.00871670702179 0.0731880516911739 0.445744179226472 GO:0050780 dopamine receptor binding 3/1239 15/18639 0.2 3.00871670702179 0.0731880516911739 0.445744179226472 GO:0141047 molecular tag activity 3/1239 15/18639 0.2 3.00871670702179 0.0731880516911739 0.445744179226472 GO:0019210 kinase inhibitor activity 10/1239 90/18639 0.111111111111111 1.67150928167877 0.075169508036382 0.454217913946658 GO:0050840 extracellular matrix binding 8/1239 67/18639 0.119402985074627 1.79624878031152 0.0754220840412354 0.454217913946658 GO:0019212 phosphatase inhibitor activity 7/1239 56/18639 0.125 1.88044794188862 0.0764776965753492 0.458016427267925 GO:0003924 GTPase activity 29/1239 331/18639 0.0876132930513595 1.31801789280411 0.0780717719503432 0.464979945649005 GO:0019211 phosphatase activator activity 4/1239 25/18639 0.16 2.40697336561743 0.0806291832624444 0.477572854708325 GO:0016504 peptidase activator activity 7/1239 57/18639 0.12280701754386 1.84745762711864 0.0824422919281778 0.485643665019539 GO:0000049 tRNA binding 9/1239 80/18639 0.1125 1.69240314769976 0.0831929187337663 0.486244511697084 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 13/1239 128/18639 0.1015625 1.5278639527845 0.0834464143450469 0.486244511697084 GO:0005159 insulin-like growth factor receptor binding 3/1239 16/18639 0.1875 2.82067191283293 0.0857940995912168 0.491947017868786 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/1239 16/18639 0.1875 2.82067191283293 0.0857940995912168 0.491947017868786 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/1239 16/18639 0.1875 2.82067191283293 0.0857940995912168 0.491947017868786 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/1239 36/18639 0.138888888888889 2.08938660209847 0.0878079191849498 0.500830353869714 GO:0019208 phosphatase regulator activity 12/1239 117/18639 0.102564102564103 1.54293164462656 0.0885280607914789 0.502280260701128 GO:0050750 low-density lipoprotein particle receptor binding 4/1239 26/18639 0.153846153846154 2.31439746693984 0.0905104278574659 0.510838959321195 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/1239 48/18639 0.125 1.88044794188862 0.0969446067460189 0.544303573292752 GO:0140299 molecular sensor activity 8/1239 71/18639 0.112676056338028 1.69505166592777 0.0980707279882653 0.547773288970726 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/1239 17/18639 0.176470588235294 2.65475003560746 0.0992448313185307 0.548645785442954 GO:0032977 membrane insertase activity 3/1239 17/18639 0.176470588235294 2.65475003560746 0.0992448313185307 0.548645785442954 GO:0004364 glutathione transferase activity 4/1239 27/18639 0.148148148148148 2.22867904223836 0.100939377663187 0.552348472695004 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/1239 27/18639 0.148148148148148 2.22867904223836 0.100939377663187 0.552348472695004 GO:0032182 ubiquitin-like protein binding 12/1239 120/18639 0.1 1.5043583535109 0.102085721317371 0.555800038283463 GO:0005496 steroid binding 11/1239 108/18639 0.101851851851852 1.53221684153888 0.103641704295666 0.561435965983557 GO:0005518 collagen binding 8/1239 72/18639 0.111111111111111 1.67150928167877 0.104272679631725 0.562029743214997 GO:0005109 frizzled binding 5/1239 38/18639 0.131578947368421 1.97941888619855 0.105112542396086 0.56373791394518 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 7/1239 61/18639 0.114754098360656 1.72631286468463 0.108876142742641 0.581032088497855 GO:0046625 sphingolipid binding 4/1239 28/18639 0.142857142857143 2.14908336215842 0.111893431143242 0.585303408813451 GO:0003746 translation elongation factor activity 3/1239 18/18639 0.166666666666667 2.50726392251816 0.113477191504649 0.585303408813451 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/1239 18/18639 0.166666666666667 2.50726392251816 0.113477191504649 0.585303408813451 GO:0008308 voltage-gated monoatomic anion channel activity 3/1239 18/18639 0.166666666666667 2.50726392251816 0.113477191504649 0.585303408813451 GO:0031690 adrenergic receptor binding 3/1239 18/18639 0.166666666666667 2.50726392251816 0.113477191504649 0.585303408813451 GO:0034185 apolipoprotein binding 3/1239 18/18639 0.166666666666667 2.50726392251816 0.113477191504649 0.585303408813451 GO:0070628 proteasome binding 3/1239 18/18639 0.166666666666667 2.50726392251816 0.113477191504649 0.585303408813451 GO:0005048 signal sequence binding 6/1239 51/18639 0.117647058823529 1.76983335707164 0.120847994005921 0.620353035897063 GO:0003785 actin monomer binding 4/1239 29/18639 0.137931034482759 2.07497703932537 0.123347847846361 0.621508898513208 GO:0043236 laminin binding 4/1239 29/18639 0.137931034482759 2.07497703932537 0.123347847846361 0.621508898513208 GO:0106222 lncRNA binding 4/1239 29/18639 0.137931034482759 2.07497703932537 0.123347847846361 0.621508898513208 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/1239 40/18639 0.125 1.88044794188862 0.123955856382504 0.621508898513208 GO:0050997 quaternary ammonium group binding 5/1239 40/18639 0.125 1.88044794188862 0.123955856382504 0.621508898513208 GO:0019842 vitamin binding 14/1239 150/18639 0.0933333333333333 1.40406779661017 0.124950486151925 0.623595481813773 GO:0043130 ubiquitin binding 10/1239 100/18639 0.1 1.5043583535109 0.12761752703732 0.623617235760141 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1239 19/18639 0.157894736842105 2.37530266343826 0.128425812930196 0.623617235760141 GO:0015245 fatty acid transmembrane transporter activity 3/1239 19/18639 0.157894736842105 2.37530266343826 0.128425812930196 0.623617235760141 GO:0031420 alkali metal ion binding 3/1239 19/18639 0.157894736842105 2.37530266343826 0.128425812930196 0.623617235760141 GO:0097001 ceramide binding 3/1239 19/18639 0.157894736842105 2.37530266343826 0.128425812930196 0.623617235760141 GO:0140036 ubiquitin-modified protein reader activity 3/1239 19/18639 0.157894736842105 2.37530266343826 0.128425812930196 0.623617235760141 GO:0017022 myosin binding 8/1239 76/18639 0.105263157894737 1.58353510895884 0.131177433427246 0.628712650689345 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/1239 41/18639 0.121951219512195 1.83458335794012 0.133923137346647 0.628712650689345 GO:0042287 MHC protein binding 5/1239 41/18639 0.121951219512195 1.83458335794012 0.133923137346647 0.628712650689345 GO:0140318 protein transporter activity 5/1239 41/18639 0.121951219512195 1.83458335794012 0.133923137346647 0.628712650689345 GO:0005319 lipid transporter activity 16/1239 178/18639 0.0898876404494382 1.35223222787496 0.135015077780626 0.628712650689345 GO:0001968 fibronectin binding 4/1239 30/18639 0.133333333333333 2.00581113801453 0.135276079599935 0.628712650689345 GO:0015215 nucleotide transmembrane transporter activity 4/1239 30/18639 0.133333333333333 2.00581113801453 0.135276079599935 0.628712650689345 GO:0016769 transferase activity, transferring nitrogenous groups 4/1239 30/18639 0.133333333333333 2.00581113801453 0.135276079599935 0.628712650689345 GO:0140296 general transcription initiation factor binding 6/1239 53/18639 0.113207547169811 1.70304719265384 0.138248037459459 0.628712650689345 GO:0005345 purine nucleobase transmembrane transporter activity 2/1239 10/18639 0.2 3.00871670702179 0.139389910496061 0.628712650689345 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/1239 10/18639 0.2 3.00871670702179 0.139389910496061 0.628712650689345 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/1239 10/18639 0.2 3.00871670702179 0.139389910496061 0.628712650689345 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/1239 10/18639 0.2 3.00871670702179 0.139389910496061 0.628712650689345 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/1239 10/18639 0.2 3.00871670702179 0.139389910496061 0.628712650689345 GO:0030957 Tat protein binding 2/1239 10/18639 0.2 3.00871670702179 0.139389910496061 0.628712650689345 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/1239 10/18639 0.2 3.00871670702179 0.139389910496061 0.628712650689345 GO:1990757 ubiquitin ligase activator activity 2/1239 10/18639 0.2 3.00871670702179 0.139389910496061 0.628712650689345 GO:0000339 RNA cap binding 3/1239 20/18639 0.15 2.25653753026634 0.144024062321656 0.637235509454582 GO:0031418 L-ascorbic acid binding 3/1239 20/18639 0.15 2.25653753026634 0.144024062321656 0.637235509454582 GO:0043024 ribosomal small subunit binding 3/1239 20/18639 0.15 2.25653753026634 0.144024062321656 0.637235509454582 GO:0052745 inositol phosphate phosphatase activity 3/1239 20/18639 0.15 2.25653753026634 0.144024062321656 0.637235509454582 GO:0016859 cis-trans isomerase activity 5/1239 42/18639 0.119047619047619 1.79090280179869 0.144235124588978 0.637235509454582 GO:0004722 protein serine/threonine phosphatase activity 10/1239 103/18639 0.0970873786407767 1.46054209078728 0.146443720009563 0.640222398966239 GO:0017069 snRNA binding 6/1239 54/18639 0.111111111111111 1.67150928167877 0.147362568072973 0.640222398966239 GO:0140463 chromatin-protein adaptor activity 6/1239 54/18639 0.111111111111111 1.67150928167877 0.147362568072973 0.640222398966239 GO:0070325 lipoprotein particle receptor binding 4/1239 31/18639 0.129032258064516 1.94110755291728 0.147650086113306 0.640222398966239 GO:0072341 modified amino acid binding 9/1239 91/18639 0.0989010989010989 1.48782694303275 0.150202497860127 0.640222398966239 GO:0020037 heme binding 13/1239 142/18639 0.0915492957746479 1.37722947856631 0.150239395182928 0.640222398966239 GO:1901681 sulfur compound binding 23/1239 275/18639 0.0836363636363636 1.25819062293639 0.151736594523007 0.640222398966239 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/1239 43/18639 0.116279069767442 1.74925389943127 0.15487630815356 0.640222398966239 GO:0008200 ion channel inhibitor activity 5/1239 43/18639 0.116279069767442 1.74925389943127 0.15487630815356 0.640222398966239 GO:0008173 RNA methyltransferase activity 7/1239 67/18639 0.104477611940299 1.57171768277258 0.155859618172287 0.640222398966239 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/1239 21/18639 0.142857142857143 2.14908336215842 0.160204927099675 0.640222398966239 GO:0051010 microtubule plus-end binding 3/1239 21/18639 0.142857142857143 2.14908336215842 0.160204927099675 0.640222398966239 GO:0051428 peptide hormone receptor binding 3/1239 21/18639 0.142857142857143 2.14908336215842 0.160204927099675 0.640222398966239 GO:1904047 S-adenosyl-L-methionine binding 3/1239 21/18639 0.142857142857143 2.14908336215842 0.160204927099675 0.640222398966239 GO:0042910 xenobiotic transmembrane transporter activity 4/1239 32/18639 0.125 1.88044794188862 0.160440633323916 0.640222398966239 GO:0140142 nucleocytoplasmic carrier activity 4/1239 32/18639 0.125 1.88044794188862 0.160440633323916 0.640222398966239 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0015173 aromatic amino acid transmembrane transporter activity 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0015205 nucleobase transmembrane transporter activity 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0019206 nucleoside kinase activity 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0032794 GTPase activating protein binding 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0034713 type I transforming growth factor beta receptor binding 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0048185 activin binding 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1239 11/18639 0.181818181818182 2.73519700638345 0.163184025978225 0.640222398966239 GO:0016248 channel inhibitor activity 5/1239 44/18639 0.113636363636364 1.70949812898965 0.165830339967787 0.640222398966239 GO:0030170 pyridoxal phosphate binding 6/1239 56/18639 0.107142857142857 1.61181252161882 0.166372323859708 0.640222398966239 GO:0170055 lipid transmembrane transporter activity 6/1239 56/18639 0.107142857142857 1.61181252161882 0.166372323859708 0.640222398966239 GO:0015101 organic cation transmembrane transporter activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:0140791 histone H2AXS140 phosphatase activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1239 81/18639 0.0987654320987654 1.48578602815891 0.169261023845434 0.640222398966239 GO:0019888 protein phosphatase regulator activity 10/1239 107/18639 0.0934579439252336 1.40594238645878 0.17360775926834 0.648249388909193 GO:0070279 vitamin B6 binding 6/1239 57/18639 0.105263157894737 1.58353510895884 0.176246445263417 0.648249388909193 GO:0070034 telomerase RNA binding 3/1239 22/18639 0.136363636363636 2.05139775478759 0.176901761580743 0.648249388909193 GO:0140784 metal ion sensor activity 3/1239 22/18639 0.136363636363636 2.05139775478759 0.176901761580743 0.648249388909193 GO:0051539 4 iron, 4 sulfur cluster binding 5/1239 45/18639 0.111111111111111 1.67150928167877 0.177080151258964 0.648249388909193 GO:0141110 transporter inhibitor activity 5/1239 45/18639 0.111111111111111 1.67150928167877 0.177080151258964 0.648249388909193 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1239 82/18639 0.0975609756097561 1.46766668635209 0.177425738475078 0.648249388909193 GO:0033549 MAP kinase phosphatase activity 8/1239 82/18639 0.0975609756097561 1.46766668635209 0.177425738475078 0.648249388909193 GO:0008028 monocarboxylic acid transmembrane transporter activity 7/1239 70/18639 0.1 1.5043583535109 0.18232742315253 0.648249388909193 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/1239 83/18639 0.0963855421686747 1.44998395519123 0.185760326569563 0.648249388909193 GO:0003713 transcription coactivator activity 21/1239 256/18639 0.08203125 1.23404396186441 0.187019679326005 0.648249388909193 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/1239 34/18639 0.117647058823529 1.76983335707164 0.187150105159673 0.648249388909193 GO:0030332 cyclin binding 4/1239 34/18639 0.117647058823529 1.76983335707164 0.187150105159673 0.648249388909193 GO:0004126 cytidine deaminase activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0004859 phospholipase inhibitor activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0005049 nuclear export signal receptor activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0015132 prostaglandin transmembrane transporter activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0015368 calcium:monoatomic cation antiporter activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0016208 AMP binding 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0016423 tRNA (guanine) methyltransferase activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0016801 hydrolase activity, acting on ether bonds 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0016803 ether hydrolase activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0035251 UDP-glucosyltransferase activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0042301 phosphate ion binding 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0070008 serine-type exopeptidase activity 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:1990459 transferrin receptor binding 2/1239 12/18639 0.166666666666667 2.50726392251816 0.187619489183366 0.648249388909193 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/1239 46/18639 0.108695652173913 1.63517212338141 0.188608066873847 0.649583054600661 GO:0044325 transmembrane transporter binding 12/1239 136/18639 0.0882352941176471 1.32737501780373 0.193476134837964 0.656460547572424 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1239 23/18639 0.130434782608696 1.96220654805769 0.194048909248304 0.656460547572424 GO:0008171 O-methyltransferase activity 3/1239 23/18639 0.130434782608696 1.96220654805769 0.194048909248304 0.656460547572424 GO:0017134 fibroblast growth factor binding 3/1239 23/18639 0.130434782608696 1.96220654805769 0.194048909248304 0.656460547572424 GO:0099186 structural constituent of postsynapse 3/1239 23/18639 0.130434782608696 1.96220654805769 0.194048909248304 0.656460547572424 GO:0017018 myosin phosphatase activity 8/1239 84/18639 0.0952380952380952 1.43272224143895 0.194258733465309 0.656460547572424 GO:0001786 phosphatidylserine binding 6/1239 59/18639 0.101694915254237 1.52985595272295 0.19667667527203 0.660490516957159 GO:0045309 protein phosphorylated amino acid binding 6/1239 59/18639 0.101694915254237 1.52985595272295 0.19667667527203 0.660490516957159 GO:0005154 epidermal growth factor receptor binding 4/1239 35/18639 0.114285714285714 1.71926668972674 0.201007016065775 0.66458206768939 GO:0016229 steroid dehydrogenase activity 4/1239 35/18639 0.114285714285714 1.71926668972674 0.201007016065775 0.66458206768939 GO:0140566 histone reader activity 4/1239 35/18639 0.114285714285714 1.71926668972674 0.201007016065775 0.66458206768939 GO:0042626 ATPase-coupled transmembrane transporter activity 9/1239 98/18639 0.0918367346938776 1.38155358995899 0.203420403554148 0.66458206768939 GO:0001098 basal transcription machinery binding 6/1239 60/18639 0.1 1.5043583535109 0.207208929672915 0.66458206768939 GO:0001099 basal RNA polymerase II transcription machinery binding 6/1239 60/18639 0.1 1.5043583535109 0.207208929672915 0.66458206768939 GO:0046906 tetrapyrrole binding 13/1239 152/18639 0.0855263157894737 1.28662227602906 0.211181033307654 0.66458206768939 GO:0015295 solute:proton symporter activity 3/1239 24/18639 0.125 1.88044794188862 0.211582216000896 0.66458206768939 GO:0050431 transforming growth factor beta binding 3/1239 24/18639 0.125 1.88044794188862 0.211582216000896 0.66458206768939 GO:0050699 WW domain binding 3/1239 24/18639 0.125 1.88044794188862 0.211582216000896 0.66458206768939 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/1239 48/18639 0.104166666666667 1.56703995157385 0.212425137862751 0.66458206768939 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0005172 vascular endothelial growth factor receptor binding 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0005542 folic acid binding 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0008035 high-density lipoprotein particle binding 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0008253 5'-nucleotidase activity 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0039706 co-receptor binding 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0043560 insulin receptor substrate binding 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0061459 L-arginine transmembrane transporter activity 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0070700 BMP receptor binding 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0071714 icosanoid transmembrane transporter activity 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1239 13/18639 0.153846153846154 2.31439746693984 0.212506102758229 0.66458206768939 GO:0030295 protein kinase activator activity 12/1239 139/18639 0.0863309352517986 1.29872663612451 0.213853728593347 0.66458206768939 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/1239 36/18639 0.111111111111111 1.67150928167877 0.215156903175878 0.66458206768939 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/1239 36/18639 0.111111111111111 1.67150928167877 0.215156903175878 0.66458206768939 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/1239 36/18639 0.111111111111111 1.67150928167877 0.215156903175878 0.66458206768939 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/1239 36/18639 0.111111111111111 1.67150928167877 0.215156903175878 0.66458206768939 GO:0003774 cytoskeletal motor activity 13/1239 153/18639 0.0849673202614379 1.2782129801073 0.217805753392169 0.669330945670663 GO:0016836 hydro-lyase activity 6/1239 61/18639 0.0983606557377049 1.47969674115826 0.217936142792581 0.669330945670663 GO:0003684 damaged DNA binding 7/1239 74/18639 0.0945945945945946 1.42304168575355 0.220251331303548 0.673069039985077 GO:0004713 protein tyrosine kinase activity 12/1239 140/18639 0.0857142857142857 1.28945001729505 0.22084194196003 0.673069039985077 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 14/1239 167/18639 0.0838323353293413 1.26113873947021 0.221026382332762 0.673069039985077 GO:0015645 fatty acid ligase activity 3/1239 25/18639 0.12 1.80523002421307 0.229439447737958 0.685348559695812 GO:0015662 P-type ion transporter activity 3/1239 25/18639 0.12 1.80523002421307 0.229439447737958 0.685348559695812 GO:0017025 TBP-class protein binding 3/1239 25/18639 0.12 1.80523002421307 0.229439447737958 0.685348559695812 GO:0047617 fatty acyl-CoA hydrolase activity 3/1239 25/18639 0.12 1.80523002421307 0.229439447737958 0.685348559695812 GO:0120515 fatty acid-CoA ligase activity 3/1239 25/18639 0.12 1.80523002421307 0.229439447737958 0.685348559695812 GO:0140358 P-type transmembrane transporter activity 3/1239 25/18639 0.12 1.80523002421307 0.229439447737958 0.685348559695812 GO:0022829 wide pore channel activity 4/1239 37/18639 0.108108108108108 1.62633335514691 0.229568375772866 0.685348559695812 GO:0019003 GDP binding 7/1239 75/18639 0.0933333333333333 1.40406779661017 0.230144878116776 0.685348559695812 GO:0008191 metalloendopeptidase inhibitor activity 2/1239 14/18639 0.142857142857143 2.14908336215842 0.237676085599834 0.69623592466473 GO:0008559 ABC-type xenobiotic transporter activity 2/1239 14/18639 0.142857142857143 2.14908336215842 0.237676085599834 0.69623592466473 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/1239 14/18639 0.142857142857143 2.14908336215842 0.237676085599834 0.69623592466473 GO:0044548 S100 protein binding 2/1239 14/18639 0.142857142857143 2.14908336215842 0.237676085599834 0.69623592466473 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/1239 14/18639 0.142857142857143 2.14908336215842 0.237676085599834 0.69623592466473 GO:1901474 azole transmembrane transporter activity 2/1239 14/18639 0.142857142857143 2.14908336215842 0.237676085599834 0.69623592466473 GO:1901682 sulfur compound transmembrane transporter activity 6/1239 63/18639 0.0952380952380952 1.43272224143895 0.239924470489392 0.700917558773886 GO:0043531 ADP binding 4/1239 38/18639 0.105263157894737 1.58353510895884 0.244210238523075 0.709761576955183 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 11/1239 130/18639 0.0846153846153846 1.27291860681691 0.246468241157406 0.709761576955183 GO:0005160 transforming growth factor beta receptor binding 3/1239 26/18639 0.115384615384615 1.73579810020488 0.247560624244108 0.709761576955183 GO:0015216 purine nucleotide transmembrane transporter activity 3/1239 26/18639 0.115384615384615 1.73579810020488 0.247560624244108 0.709761576955183 GO:0016289 acyl-CoA hydrolase activity 3/1239 26/18639 0.115384615384615 1.73579810020488 0.247560624244108 0.709761576955183 GO:0050681 nuclear androgen receptor binding 3/1239 26/18639 0.115384615384615 1.73579810020488 0.247560624244108 0.709761576955183 GO:0097602 cullin family protein binding 3/1239 26/18639 0.115384615384615 1.73579810020488 0.247560624244108 0.709761576955183 GO:0016830 carbon-carbon lyase activity 5/1239 51/18639 0.0980392156862745 1.47486113089304 0.249771695521681 0.71420129382592 GO:0008201 heparin binding 14/1239 172/18639 0.0813953488372093 1.22447772960189 0.254091441895756 0.723155135276578 GO:0031072 heat shock protein binding 11/1239 131/18639 0.083969465648855 1.26320167088701 0.254244708970151 0.723155135276578 GO:0005539 glycosaminoglycan binding 19/1239 242/18639 0.0785123966942149 1.18110779821103 0.258128847583352 0.725049943872347 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/1239 39/18639 0.102564102564103 1.54293164462656 0.259051656209936 0.725049943872347 GO:0005179 hormone activity 11/1239 132/18639 0.0833333333333333 1.25363196125908 0.262105252035895 0.725049943872347 GO:0000774 adenyl-nucleotide exchange factor activity 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0005523 tropomyosin binding 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0008252 nucleotidase activity 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0015929 hexosaminidase activity 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0016846 carbon-sulfur lyase activity 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0033130 acetylcholine receptor binding 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0050700 CARD domain binding 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0120283 protein serine/threonine kinase binding 2/1239 15/18639 0.133333333333333 2.00581113801453 0.262981936970397 0.725049943872347 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 18/1239 229/18639 0.0786026200873362 1.18246508136228 0.263799146880438 0.725447653921204 GO:0016405 CoA-ligase activity 3/1239 27/18639 0.111111111111111 1.67150928167877 0.265888280066723 0.729332228783532 GO:0052689 carboxylic ester hydrolase activity 8/1239 92/18639 0.0869565217391304 1.30813769870513 0.267344094216159 0.731464298388374 GO:0046943 carboxylic acid transmembrane transporter activity 15/1239 188/18639 0.0797872340425532 1.20028592035444 0.268744841497413 0.733435288947371 GO:0051020 GTPase binding 24/1239 315/18639 0.0761904761904762 1.14617779315116 0.272551777180001 0.738851936137695 GO:0004532 RNA exonuclease activity 4/1239 40/18639 0.1 1.5043583535109 0.274062300635206 0.738851936137695 GO:0061791 GTPase motor activity 4/1239 40/18639 0.1 1.5043583535109 0.274062300635206 0.738851936137695 GO:1990606 membrane scission GTPase motor activity 4/1239 40/18639 0.1 1.5043583535109 0.274062300635206 0.738851936137695 GO:0005342 organic acid transmembrane transporter activity 15/1239 189/18639 0.0793650793650794 1.19393520119912 0.275437786041833 0.738851936137695 GO:0004864 protein phosphatase inhibitor activity 5/1239 53/18639 0.0943396226415094 1.4192059938782 0.275527345387155 0.738851936137695 GO:0005544 calcium-dependent phospholipid binding 5/1239 53/18639 0.0943396226415094 1.4192059938782 0.275527345387155 0.738851936137695 GO:0051219 phosphoprotein binding 8/1239 93/18639 0.0860215053763441 1.29407170194486 0.277010061427646 0.740984730071966 GO:0019209 kinase activator activity 12/1239 148/18639 0.0810810810810811 1.21975001636019 0.27981752008043 0.74408366091957 GO:0008168 methyltransferase activity 16/1239 204/18639 0.0784313725490196 1.17988890471443 0.28231914832161 0.74408366091957 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 3/1239 28/18639 0.107142857142857 1.61181252161882 0.284367661937541 0.74408366091957 GO:0097718 disordered domain specific binding 3/1239 28/18639 0.107142857142857 1.61181252161882 0.284367661937541 0.74408366091957 GO:0016410 N-acyltransferase activity 8/1239 94/18639 0.0851063829787234 1.2803049817114 0.286768988113285 0.74408366091957 GO:0000062 fatty-acyl-CoA binding 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0004708 MAP kinase kinase activity 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0005149 interleukin-1 receptor binding 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0005521 lamin binding 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0017070 U6 snRNA binding 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0022858 alanine transmembrane transporter activity 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0055102 lipase inhibitor activity 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0140328 floppase activity 2/1239 16/18639 0.125 1.88044794188862 0.288294485167423 0.74408366091957 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/1239 54/18639 0.0925925925925926 1.39292440139898 0.288605383888602 0.74408366091957 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/1239 41/18639 0.0975609756097561 1.46766668635209 0.289212480450185 0.74408366091957 GO:0030145 manganese ion binding 6/1239 68/18639 0.0882352941176471 1.32737501780373 0.297399435512379 0.763325217815106 GO:0042277 peptide binding 19/1239 249/18639 0.0763052208835341 1.14790396452639 0.299496568913246 0.766881950803988 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/1239 29/18639 0.103448275862069 1.55623277949403 0.302946871255754 0.772049000505209 GO:0051861 glycolipid binding 3/1239 29/18639 0.103448275862069 1.55623277949403 0.302946871255754 0.772049000505209 GO:0019894 kinesin binding 4/1239 42/18639 0.0952380952380952 1.43272224143895 0.304473254751365 0.772287455581109 GO:0051879 Hsp90 protein binding 4/1239 42/18639 0.0952380952380952 1.43272224143895 0.304473254751365 0.772287455581109 GO:0016407 acetyltransferase activity 8/1239 96/18639 0.0833333333333333 1.25363196125908 0.306535020190104 0.775691905551485 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/1239 17/18639 0.117647058823529 1.76983335707164 0.313501105680608 0.78411645457934 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1239 17/18639 0.117647058823529 1.76983335707164 0.313501105680608 0.78411645457934 GO:0031489 myosin V binding 2/1239 17/18639 0.117647058823529 1.76983335707164 0.313501105680608 0.78411645457934 GO:0070402 NADPH binding 2/1239 17/18639 0.117647058823529 1.76983335707164 0.313501105680608 0.78411645457934 GO:1901567 fatty acid derivative binding 2/1239 17/18639 0.117647058823529 1.76983335707164 0.313501105680608 0.78411645457934 GO:1902936 phosphatidylinositol bisphosphate binding 9/1239 111/18639 0.0810810810810811 1.21975001636019 0.31812429779279 0.789658227873526 GO:0016874 ligase activity 13/1239 167/18639 0.0778443113772455 1.17105740093663 0.318401742476217 0.789658227873526 GO:0097110 scaffold protein binding 6/1239 70/18639 0.0857142857142857 1.28945001729505 0.321114147700592 0.789658227873526 GO:0001965 G-protein alpha-subunit binding 3/1239 30/18639 0.1 1.5043583535109 0.321576959217512 0.789658227873526 GO:0031210 phosphatidylcholine binding 3/1239 30/18639 0.1 1.5043583535109 0.321576959217512 0.789658227873526 GO:0035925 mRNA 3'-UTR AU-rich region binding 3/1239 30/18639 0.1 1.5043583535109 0.321576959217512 0.789658227873526 GO:0048019 receptor antagonist activity 3/1239 30/18639 0.1 1.5043583535109 0.321576959217512 0.789658227873526 GO:0098918 structural constituent of synapse 3/1239 30/18639 0.1 1.5043583535109 0.321576959217512 0.789658227873526 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/1239 57/18639 0.087719298245614 1.31961259079903 0.328416522829781 0.804620480932964 GO:0030547 signaling receptor inhibitor activity 4/1239 44/18639 0.0909090909090909 1.36759850319172 0.33521515046127 0.816347683129544 GO:0035091 phosphatidylinositol binding 21/1239 284/18639 0.073943661971831 1.1123776557651 0.338121350994651 0.816347683129544 GO:0000400 four-way junction DNA binding 2/1239 18/18639 0.111111111111111 1.67150928167877 0.338504094952603 0.816347683129544 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1239 18/18639 0.111111111111111 1.67150928167877 0.338504094952603 0.816347683129544 GO:0016854 racemase and epimerase activity 2/1239 18/18639 0.111111111111111 1.67150928167877 0.338504094952603 0.816347683129544 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/1239 18/18639 0.111111111111111 1.67150928167877 0.338504094952603 0.816347683129544 GO:0070064 proline-rich region binding 2/1239 18/18639 0.111111111111111 1.67150928167877 0.338504094952603 0.816347683129544 GO:0008237 metallopeptidase activity 14/1239 184/18639 0.0760869565217391 1.14462048636699 0.339688690623587 0.816811839376423 GO:0016878 acid-thiol ligase activity 3/1239 31/18639 0.0967741935483871 1.45583066468796 0.34021198133582 0.816811839376423 GO:0046915 transition metal ion transmembrane transporter activity 4/1239 45/18639 0.0888888888888889 1.33720742534302 0.350642955261495 0.838437437982328 GO:0031593 polyubiquitin modification-dependent protein binding 5/1239 59/18639 0.0847457627118644 1.27487996060245 0.355257944938521 0.838437437982328 GO:0017124 SH3 domain binding 9/1239 115/18639 0.0782608695652174 1.17732392883461 0.355989663201617 0.838437437982328 GO:0035401 histone H3Y41 kinase activity 9/1239 115/18639 0.0782608695652174 1.17732392883461 0.355989663201617 0.838437437982328 GO:0140801 histone H2AXY142 kinase activity 9/1239 115/18639 0.0782608695652174 1.17732392883461 0.355989663201617 0.838437437982328 GO:0015291 secondary active transmembrane transporter activity 21/1239 287/18639 0.0731707317073171 1.10075001476407 0.356052293843194 0.838437437982328 GO:0016741 transferase activity, transferring one-carbon groups 16/1239 215/18639 0.0744186046511628 1.11952249563602 0.356772981871187 0.838437437982328 GO:0015106 bicarbonate transmembrane transporter activity 3/1239 32/18639 0.09375 1.41033595641646 0.358809017337052 0.838437437982328 GO:0031369 translation initiation factor binding 3/1239 32/18639 0.09375 1.41033595641646 0.358809017337052 0.838437437982328 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1239 32/18639 0.09375 1.41033595641646 0.358809017337052 0.838437437982328 GO:0051059 NF-kappaB binding 3/1239 32/18639 0.09375 1.41033595641646 0.358809017337052 0.838437437982328 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1239 19/18639 0.105263157894737 1.58353510895884 0.363219186955239 0.838437437982328 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/1239 19/18639 0.105263157894737 1.58353510895884 0.363219186955239 0.838437437982328 GO:0042800 histone H3K4 methyltransferase activity 2/1239 19/18639 0.105263157894737 1.58353510895884 0.363219186955239 0.838437437982328 GO:0046527 glucosyltransferase activity 2/1239 19/18639 0.105263157894737 1.58353510895884 0.363219186955239 0.838437437982328 GO:0046624 sphingolipid transporter activity 2/1239 19/18639 0.105263157894737 1.58353510895884 0.363219186955239 0.838437437982328 GO:0070003 threonine-type peptidase activity 2/1239 19/18639 0.105263157894737 1.58353510895884 0.363219186955239 0.838437437982328 GO:0120227 acyl-CoA binding 2/1239 19/18639 0.105263157894737 1.58353510895884 0.363219186955239 0.838437437982328 GO:0015171 amino acid transmembrane transporter activity 8/1239 102/18639 0.0784313725490196 1.17988890471443 0.367265323662462 0.845965852367809 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/1239 60/18639 0.0833333333333333 1.25363196125908 0.368716946326303 0.847498652750009 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/1239 33/18639 0.0909090909090909 1.36759850319172 0.377328161738041 0.859251013311892 GO:0019239 deaminase activity 3/1239 33/18639 0.0909090909090909 1.36759850319172 0.377328161738041 0.859251013311892 GO:0140311 protein sequestering activity 3/1239 33/18639 0.0909090909090909 1.36759850319172 0.377328161738041 0.859251013311892 GO:0005253 monoatomic anion channel activity 8/1239 103/18639 0.0776699029126214 1.16843367262982 0.377516092726606 0.859251013311892 GO:0033218 amide binding 18/1239 247/18639 0.0728744939271255 1.0962935369715 0.37781538062137 0.859251013311892 GO:0003727 single-stranded RNA binding 7/1239 89/18639 0.0786516853932584 1.18320319939059 0.379635210931407 0.860340621297128 GO:0001784 phosphotyrosine residue binding 4/1239 47/18639 0.0851063829787234 1.2803049817114 0.381486843209673 0.860340621297128 GO:0005504 fatty acid binding 4/1239 47/18639 0.0851063829787234 1.2803049817114 0.381486843209673 0.860340621297128 GO:0043495 protein-membrane adaptor activity 4/1239 47/18639 0.0851063829787234 1.2803049817114 0.381486843209673 0.860340621297128 GO:0005543 phospholipid binding 35/1239 497/18639 0.0704225352112676 1.05940729120486 0.385887584285944 0.861453584466146 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1239 20/18639 0.1 1.5043583535109 0.387574200803415 0.861453584466146 GO:0005326 neurotransmitter transmembrane transporter activity 2/1239 20/18639 0.1 1.5043583535109 0.387574200803415 0.861453584466146 GO:0016408 C-acyltransferase activity 2/1239 20/18639 0.1 1.5043583535109 0.387574200803415 0.861453584466146 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1239 20/18639 0.1 1.5043583535109 0.387574200803415 0.861453584466146 GO:0030742 GTP-dependent protein binding 2/1239 20/18639 0.1 1.5043583535109 0.387574200803415 0.861453584466146 GO:0061608 nuclear import signal receptor activity 2/1239 20/18639 0.1 1.5043583535109 0.387574200803415 0.861453584466146 GO:0008083 growth factor activity 12/1239 162/18639 0.0740740740740741 1.11433952111918 0.391972118844989 0.869436099001847 GO:0015179 L-amino acid transmembrane transporter activity 5/1239 62/18639 0.0806451612903226 1.2131922205733 0.395629859734729 0.870611477546828 GO:0016831 carboxy-lyase activity 3/1239 34/18639 0.0882352941176471 1.32737501780373 0.395732489794013 0.870611477546828 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/1239 34/18639 0.0882352941176471 1.32737501780373 0.395732489794013 0.870611477546828 GO:0051427 hormone receptor binding 3/1239 34/18639 0.0882352941176471 1.32737501780373 0.395732489794013 0.870611477546828 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/1239 91/18639 0.0769230769230769 1.15719873346992 0.401787461126385 0.882132144794791 GO:0015297 antiporter activity 10/1239 135/18639 0.0740740740740741 1.11433952111918 0.408937571296347 0.888988812884802 GO:0001846 opsonin binding 2/1239 21/18639 0.0952380952380952 1.43272224143895 0.411507808561703 0.888988812884802 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1239 21/18639 0.0952380952380952 1.43272224143895 0.411507808561703 0.888988812884802 GO:0008373 sialyltransferase activity 2/1239 21/18639 0.0952380952380952 1.43272224143895 0.411507808561703 0.888988812884802 GO:0009975 cyclase activity 2/1239 21/18639 0.0952380952380952 1.43272224143895 0.411507808561703 0.888988812884802 GO:0015174 basic amino acid transmembrane transporter activity 2/1239 21/18639 0.0952380952380952 1.43272224143895 0.411507808561703 0.888988812884802 GO:0061891 calcium ion sensor activity 2/1239 21/18639 0.0952380952380952 1.43272224143895 0.411507808561703 0.888988812884802 GO:0070182 DNA polymerase binding 2/1239 21/18639 0.0952380952380952 1.43272224143895 0.411507808561703 0.888988812884802 GO:0000175 3'-5'-RNA exonuclease activity 3/1239 35/18639 0.0857142857142857 1.28945001729505 0.413988002956035 0.892558134373211 GO:0008236 serine-type peptidase activity 14/1239 194/18639 0.0721649484536082 1.08561943036869 0.414961492152846 0.892871234612311 GO:0019199 transmembrane receptor protein kinase activity 6/1239 78/18639 0.0769230769230769 1.15719873346992 0.41756281371333 0.89667871151986 GO:0015605 organophosphate ester transmembrane transporter activity 4/1239 50/18639 0.08 1.20348668280872 0.427380802142662 0.915937385108925 GO:0016881 acid-amino acid ligase activity 2/1239 22/18639 0.0909090909090909 1.36759850319172 0.434968413259799 0.918992993470514 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1239 22/18639 0.0909090909090909 1.36759850319172 0.434968413259799 0.918992993470514 GO:0034062 5'-3' RNA polymerase activity 2/1239 22/18639 0.0909090909090909 1.36759850319172 0.434968413259799 0.918992993470514 GO:0097747 RNA polymerase activity 2/1239 22/18639 0.0909090909090909 1.36759850319172 0.434968413259799 0.918992993470514 GO:0030544 Hsp70 protein binding 4/1239 51/18639 0.0784313725490196 1.17988890471443 0.442496470791255 0.918992993470514 GO:0017171 serine hydrolase activity 14/1239 198/18639 0.0707070707070707 1.06368772470467 0.445369023212199 0.918992993470514 GO:0004867 serine-type endopeptidase inhibitor activity 7/1239 95/18639 0.0736842105263158 1.10847457627119 0.445955833224099 0.918992993470514 GO:0008276 protein methyltransferase activity 7/1239 95/18639 0.0736842105263158 1.10847457627119 0.445955833224099 0.918992993470514 GO:0043394 proteoglycan binding 3/1239 37/18639 0.0810810810810811 1.21975001636019 0.449930779396971 0.918992993470514 GO:0005158 insulin receptor binding 2/1239 23/18639 0.0869565217391304 1.30813769870513 0.457913127927561 0.918992993470514 GO:0016849 phosphorus-oxygen lyase activity 2/1239 23/18639 0.0869565217391304 1.30813769870513 0.457913127927561 0.918992993470514 GO:0031681 G-protein beta-subunit binding 2/1239 23/18639 0.0869565217391304 1.30813769870513 0.457913127927561 0.918992993470514 GO:0042171 lysophosphatidic acid acyltransferase activity 2/1239 23/18639 0.0869565217391304 1.30813769870513 0.457913127927561 0.918992993470514 GO:0043274 phospholipase binding 2/1239 23/18639 0.0869565217391304 1.30813769870513 0.457913127927561 0.918992993470514 GO:0071617 lysophospholipid acyltransferase activity 2/1239 23/18639 0.0869565217391304 1.30813769870513 0.457913127927561 0.918992993470514 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/1239 67/18639 0.0746268656716418 1.1226554876947 0.462185977966819 0.918992993470514 GO:0000146 microfilament motor activity 3/1239 38/18639 0.0789473684210526 1.18765133171913 0.467563968614734 0.918992993470514 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1239 38/18639 0.0789473684210526 1.18765133171913 0.467563968614734 0.918992993470514 GO:0042162 telomeric DNA binding 3/1239 38/18639 0.0789473684210526 1.18765133171913 0.467563968614734 0.918992993470514 GO:0005246 calcium channel regulator activity 4/1239 53/18639 0.0754716981132075 1.13536479510256 0.472343882705291 0.918992993470514 GO:0034212 protein N-acetyltransferase activity 4/1239 53/18639 0.0754716981132075 1.13536479510256 0.472343882705291 0.918992993470514 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/1239 53/18639 0.0754716981132075 1.13536479510256 0.472343882705291 0.918992993470514 GO:0003777 microtubule motor activity 5/1239 68/18639 0.0735294117647059 1.10614584816978 0.475264274987012 0.918992993470514 GO:0005548 phospholipid transporter activity 5/1239 68/18639 0.0735294117647059 1.10614584816978 0.475264274987012 0.918992993470514 GO:0008170 N-methyltransferase activity 7/1239 98/18639 0.0714285714285714 1.07454168107921 0.478707301637851 0.918992993470514 GO:0015149 hexose transmembrane transporter activity 2/1239 24/18639 0.0833333333333333 1.25363196125908 0.480306847193621 0.918992993470514 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1239 24/18639 0.0833333333333333 1.25363196125908 0.480306847193621 0.918992993470514 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1239 24/18639 0.0833333333333333 1.25363196125908 0.480306847193621 0.918992993470514 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1239 24/18639 0.0833333333333333 1.25363196125908 0.480306847193621 0.918992993470514 GO:0055056 D-glucose transmembrane transporter activity 2/1239 24/18639 0.0833333333333333 1.25363196125908 0.480306847193621 0.918992993470514 GO:0070300 phosphatidic acid binding 2/1239 24/18639 0.0833333333333333 1.25363196125908 0.480306847193621 0.918992993470514 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1239 24/18639 0.0833333333333333 1.25363196125908 0.480306847193621 0.918992993470514 GO:0070840 dynein complex binding 2/1239 24/18639 0.0833333333333333 1.25363196125908 0.480306847193621 0.918992993470514 GO:0140597 protein carrier chaperone 13/1239 188/18639 0.0691489361702128 1.04024779764051 0.482868620072075 0.918992993470514 GO:0140297 DNA-binding transcription factor binding 33/1239 488/18639 0.0676229508196721 1.0172915095463 0.485433199595605 0.918992993470514 GO:0050661 NADP binding 4/1239 54/18639 0.0740740740740741 1.11433952111918 0.487042962610626 0.918992993470514 GO:0008080 N-acetyltransferase activity 5/1239 69/18639 0.072463768115942 1.09011474892094 0.488236629068862 0.918992993470514 GO:0004527 exonuclease activity 6/1239 84/18639 0.0714285714285714 1.07454168107921 0.488996183905606 0.918992993470514 GO:0019955 cytokine binding 10/1239 144/18639 0.0694444444444444 1.04469330104923 0.490344832999476 0.918992993470514 GO:0046982 protein heterodimerization activity 25/1239 369/18639 0.0677506775067751 1.0192129766334 0.490670583295295 0.918992993470514 GO:0004090 carbonyl reductase (NADPH) activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0005337 nucleoside transmembrane transporter activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0005381 iron ion transmembrane transporter activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0005528 FK506 binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0008140 cAMP response element binding protein binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0008190 eukaryotic initiation factor 4E binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0008239 dipeptidyl-peptidase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0016868 intramolecular phosphotransferase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0019531 oxalate transmembrane transporter activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0019911 structural constituent of myelin sheath 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0031996 thioesterase binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0032052 bile acid binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0032356 oxidized DNA binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0033204 ribonuclease P RNA binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0042975 peroxisome proliferator activated receptor binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0050815 phosphoserine residue binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0051880 G-quadruplex DNA binding 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0140135 mechanosensitive monoatomic cation channel activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0140940 histone H2A methyltransferase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0140999 histone H3K4 trimethyltransferase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:1990259 histone H2AQ104 methyltransferase activity 1/1239 10/18639 0.1 1.5043583535109 0.497435611075417 0.918992993470514 GO:0004721 phosphoprotein phosphatase activity 12/1239 175/18639 0.0685714285714286 1.03156001383604 0.498716394005744 0.918992993470514 GO:0008374 O-acyltransferase activity 4/1239 55/18639 0.0727272727272727 1.09407880255338 0.501572461904604 0.918992993470514 GO:0015144 carbohydrate transmembrane transporter activity 3/1239 40/18639 0.075 1.12826876513317 0.502038186054948 0.918992993470514 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/1239 40/18639 0.075 1.12826876513317 0.502038186054948 0.918992993470514 GO:0071855 neuropeptide receptor binding 3/1239 40/18639 0.075 1.12826876513317 0.502038186054948 0.918992993470514 GO:0000030 mannosyltransferase activity 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0001848 complement binding 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0005537 D-mannose binding 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0008139 nuclear localization sequence binding 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0008483 transaminase activity 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0019707 protein-cysteine S-acyltransferase activity 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0042974 nuclear retinoic acid receptor binding 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0120020 cholesterol transfer activity 2/1239 25/18639 0.08 1.20348668280872 0.502121403668027 0.918992993470514 GO:0004252 serine-type endopeptidase activity 12/1239 176/18639 0.0681818181818182 1.02569887739379 0.506799925629706 0.923831087698898 GO:0015293 symporter activity 10/1239 146/18639 0.0684931506849315 1.03038243391157 0.508129737853237 0.923831087698898 GO:0001664 G protein-coupled receptor binding 20/1239 297/18639 0.0673400673400673 1.01303592829017 0.509548555337147 0.923831087698898 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/1239 86/18639 0.0697674418604651 1.04955233965876 0.512210399715898 0.923831087698898 GO:0050660 flavin adenine dinucleotide binding 6/1239 86/18639 0.0697674418604651 1.04955233965876 0.512210399715898 0.923831087698898 GO:0017080 sodium channel regulator activity 3/1239 41/18639 0.0731707317073171 1.10075001476407 0.518840215444798 0.923831087698898 GO:0004529 DNA exonuclease activity 2/1239 26/18639 0.0769230769230769 1.15719873346992 0.523334801953353 0.923831087698898 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/1239 26/18639 0.0769230769230769 1.15719873346992 0.523334801953353 0.923831087698898 GO:0008143 poly(A) binding 2/1239 26/18639 0.0769230769230769 1.15719873346992 0.523334801953353 0.923831087698898 GO:0008157 protein phosphatase 1 binding 2/1239 26/18639 0.0769230769230769 1.15719873346992 0.523334801953353 0.923831087698898 GO:0015145 monosaccharide transmembrane transporter activity 2/1239 26/18639 0.0769230769230769 1.15719873346992 0.523334801953353 0.923831087698898 GO:0120014 phospholipid transfer activity 2/1239 26/18639 0.0769230769230769 1.15719873346992 0.523334801953353 0.923831087698898 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0005225 volume-sensitive anion channel activity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0008432 JUN kinase binding 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0032050 clathrin heavy chain binding 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0034056 estrogen response element binding 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0042608 T cell receptor binding 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0097493 structural molecule activity conferring elasticity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0180030 inositol phosphate kinase activity 1/1239 11/18639 0.0909090909090909 1.36759850319172 0.530860769585136 0.923831087698898 GO:0035198 miRNA binding 3/1239 42/18639 0.0714285714285714 1.07454168107921 0.535329981651985 0.923831087698898 GO:0048487 beta-tubulin binding 3/1239 42/18639 0.0714285714285714 1.07454168107921 0.535329981651985 0.923831087698898 GO:0005385 zinc ion transmembrane transporter activity 2/1239 27/18639 0.0740740740740741 1.11433952111918 0.543930523704283 0.923831087698898 GO:0008266 poly(U) RNA binding 2/1239 27/18639 0.0740740740740741 1.11433952111918 0.543930523704283 0.923831087698898 GO:0023026 MHC class II protein complex binding 2/1239 27/18639 0.0740740740740741 1.11433952111918 0.543930523704283 0.923831087698898 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1239 27/18639 0.0740740740740741 1.11433952111918 0.543930523704283 0.923831087698898 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/1239 27/18639 0.0740740740740741 1.11433952111918 0.543930523704283 0.923831087698898 GO:0008408 3'-5' exonuclease activity 4/1239 58/18639 0.0689655172413793 1.03748851966269 0.544014597901873 0.923831087698898 GO:0016791 phosphatase activity 18/1239 273/18639 0.0659340659340659 0.991884628688503 0.549528724807188 0.923831087698898 GO:0003678 DNA helicase activity 5/1239 74/18639 0.0675675675675676 1.01645834696682 0.551152599760549 0.923831087698898 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1239 43/18639 0.0697674418604651 1.04955233965876 0.551493490426471 0.923831087698898 GO:0048156 tau protein binding 3/1239 43/18639 0.0697674418604651 1.04955233965876 0.551493490426471 0.923831087698898 GO:0140789 histone phosphatase activity 9/1239 136/18639 0.0661764705882353 0.995531263352799 0.554858322605474 0.923831087698898 GO:0070063 RNA polymerase binding 4/1239 59/18639 0.0677966101694915 1.01990396848196 0.557742354481026 0.923831087698898 GO:0004540 RNA nuclease activity 8/1239 121/18639 0.0661157024793388 0.994617093230344 0.558527922933263 0.923831087698898 GO:0000340 RNA 7-methylguanosine cap binding 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0004000 adenosine deaminase activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0004032 aldose reductase (NADPH) activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0004526 ribonuclease P activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0004875 complement receptor activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0005025 transforming growth factor beta receptor activity, type I 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0005026 transforming growth factor beta receptor activity, type II 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0005078 MAP-kinase scaffold activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0005165 neurotrophin receptor binding 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0005527 macrolide binding 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0015166 polyol transmembrane transporter activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0016361 activin receptor activity, type I 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0016362 activin receptor activity, type II 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0017002 activin receptor activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0034452 dynactin binding 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0035259 nuclear glucocorticoid receptor binding 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0036009 protein-glutamine N-methyltransferase activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0045295 gamma-catenin binding 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0097371 MDM2/MDM4 family protein binding 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:1990817 poly(A) RNA polymerase activity 1/1239 12/18639 0.0833333333333333 1.25363196125908 0.562064522348933 0.923831087698898 GO:0016922 nuclear receptor binding 9/1239 137/18639 0.0656934306569343 0.988264611795479 0.563839166434829 0.923831087698898 GO:0046875 ephrin receptor binding 2/1239 28/18639 0.0714285714285714 1.07454168107921 0.56389689768634 0.923831087698898 GO:0051119 sugar transmembrane transporter activity 2/1239 28/18639 0.0714285714285714 1.07454168107921 0.56389689768634 0.923831087698898 GO:0001046 core promoter sequence-specific DNA binding 3/1239 44/18639 0.0681818181818182 1.02569887739379 0.567318734814169 0.924607774726955 GO:0043014 alpha-tubulin binding 3/1239 44/18639 0.0681818181818182 1.02569887739379 0.567318734814169 0.924607774726955 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/1239 60/18639 0.0666666666666667 1.00290556900726 0.571244169349221 0.924607774726955 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4/1239 60/18639 0.0666666666666667 1.00290556900726 0.571244169349221 0.924607774726955 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/1239 60/18639 0.0666666666666667 1.00290556900726 0.571244169349221 0.924607774726955 GO:1901981 phosphatidylinositol phosphate binding 12/1239 185/18639 0.0648648648648649 0.975800013088149 0.57768411702454 0.924607774726955 GO:0070851 growth factor receptor binding 9/1239 139/18639 0.0647482014388489 0.974044977093386 0.581566173986281 0.924607774726955 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/1239 45/18639 0.0666666666666667 1.00290556900726 0.582795576210788 0.924607774726955 GO:0042605 peptide antigen binding 3/1239 45/18639 0.0666666666666667 1.00290556900726 0.582795576210788 0.924607774726955 GO:0140303 intramembrane lipid transporter activity 3/1239 45/18639 0.0666666666666667 1.00290556900726 0.582795576210788 0.924607774726955 GO:0004629 phospholipase C activity 2/1239 29/18639 0.0689655172413793 1.03748851966269 0.583226529273791 0.924607774726955 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1239 29/18639 0.0689655172413793 1.03748851966269 0.583226529273791 0.924607774726955 GO:0016417 S-acyltransferase activity 2/1239 29/18639 0.0689655172413793 1.03748851966269 0.583226529273791 0.924607774726955 GO:0097472 cyclin-dependent protein kinase activity 2/1239 29/18639 0.0689655172413793 1.03748851966269 0.583226529273791 0.924607774726955 GO:0004386 helicase activity 10/1239 155/18639 0.0645161290322581 0.970553776458642 0.585505084412351 0.924607774726955 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0035673 oligopeptide transmembrane transporter activity 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0046975 histone H3K36 methyltransferase activity 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0070123 transforming growth factor beta receptor activity, type III 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0089720 caspase binding 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0097157 pre-mRNA intronic binding 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0140333 glycerophospholipid flippase activity 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0140666 annealing activity 1/1239 13/18639 0.0769230769230769 1.15719873346992 0.591194390648159 0.924607774726955 GO:0031406 carboxylic acid binding 12/1239 187/18639 0.0641711229946524 0.965363649311805 0.592866718473757 0.924607774726955 GO:0004180 carboxypeptidase activity 3/1239 46/18639 0.0652173913043478 0.981103274028845 0.597915626918961 0.924607774726955 GO:0030291 protein serine/threonine kinase inhibitor activity 3/1239 46/18639 0.0652173913043478 0.981103274028845 0.597915626918961 0.924607774726955 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/1239 30/18639 0.0666666666666667 1.00290556900726 0.601915784277811 0.924607774726955 GO:0008187 poly-pyrimidine tract binding 2/1239 30/18639 0.0666666666666667 1.00290556900726 0.601915784277811 0.924607774726955 GO:0031624 ubiquitin conjugating enzyme binding 2/1239 30/18639 0.0666666666666667 1.00290556900726 0.601915784277811 0.924607774726955 GO:0033612 receptor serine/threonine kinase binding 2/1239 30/18639 0.0666666666666667 1.00290556900726 0.601915784277811 0.924607774726955 GO:0043177 organic acid binding 12/1239 189/18639 0.0634920634920635 0.955148160959299 0.607802812527573 0.924607774726955 GO:0140658 ATP-dependent chromatin remodeler activity 10/1239 158/18639 0.0632911392405063 0.95212554019677 0.610062050496926 0.924607774726955 GO:0033293 monocarboxylic acid binding 5/1239 79/18639 0.0632911392405063 0.95212554019677 0.610065490633392 0.924607774726955 GO:0046332 SMAD binding 5/1239 79/18639 0.0632911392405063 0.95212554019677 0.610065490633392 0.924607774726955 GO:0061733 protein-lysine-acetyltransferase activity 3/1239 47/18639 0.0638297872340425 0.960228736283551 0.61267213489914 0.924607774726955 GO:0061749 forked DNA-dependent helicase activity 3/1239 47/18639 0.0638297872340425 0.960228736283551 0.61267213489914 0.924607774726955 GO:0140359 ABC-type transporter activity 3/1239 47/18639 0.0638297872340425 0.960228736283551 0.61267213489914 0.924607774726955 GO:1990518 single-stranded 3'-5' DNA helicase activity 3/1239 47/18639 0.0638297872340425 0.960228736283551 0.61267213489914 0.924607774726955 GO:0019902 phosphatase binding 12/1239 190/18639 0.0631578947368421 0.950121065375303 0.615173477639849 0.924607774726955 GO:0004065 arylsulfatase activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0004705 JUN kinase activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0005545 1-phosphatidylinositol binding 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0008494 translation activator activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0032454 histone H3K9 demethylase activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0046030 inositol trisphosphate phosphatase activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0070742 C2H2 zinc finger domain binding 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0071933 Arp2/3 complex binding 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0098599 palmitoyl hydrolase activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0098821 BMP receptor activity 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:1901612 cardiolipin binding 1/1239 14/18639 0.0714285714285714 1.07454168107921 0.618388106421107 0.924607774726955 GO:0005164 tumor necrosis factor receptor binding 2/1239 31/18639 0.0645161290322581 0.970553776458642 0.619964322411742 0.924607774726955 GO:0005184 neuropeptide hormone activity 2/1239 31/18639 0.0645161290322581 0.970553776458642 0.619964322411742 0.924607774726955 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1239 31/18639 0.0645161290322581 0.970553776458642 0.619964322411742 0.924607774726955 GO:0005452 solute:inorganic anion antiporter activity 2/1239 31/18639 0.0645161290322581 0.970553776458642 0.619964322411742 0.924607774726955 GO:0016411 acylglycerol O-acyltransferase activity 2/1239 31/18639 0.0645161290322581 0.970553776458642 0.619964322411742 0.924607774726955 GO:0047499 calcium-independent phospholipase A2 activity 2/1239 31/18639 0.0645161290322581 0.970553776458642 0.619964322411742 0.924607774726955 GO:0072349 modified amino acid transmembrane transporter activity 2/1239 31/18639 0.0645161290322581 0.970553776458642 0.619964322411742 0.924607774726955 GO:0004536 DNA nuclease activity 4/1239 64/18639 0.0625 0.94022397094431 0.622842443665612 0.924607774726955 GO:0019903 protein phosphatase binding 9/1239 144/18639 0.0625 0.94022397094431 0.62437025115896 0.924607774726955 GO:0005516 calmodulin binding 13/1239 207/18639 0.0628019323671498 0.944766115731481 0.624717919964072 0.924607774726955 GO:0008188 neuropeptide receptor activity 3/1239 48/18639 0.0625 0.94022397094431 0.627059871282395 0.924607774726955 GO:0009378 four-way junction helicase activity 3/1239 48/18639 0.0625 0.94022397094431 0.627059871282395 0.924607774726955 GO:0036121 double-stranded DNA helicase activity 3/1239 48/18639 0.0625 0.94022397094431 0.627059871282395 0.924607774726955 GO:0043138 3'-5' DNA helicase activity 3/1239 48/18639 0.0625 0.94022397094431 0.627059871282395 0.924607774726955 GO:0038024 cargo receptor activity 4/1239 65/18639 0.0615384615384615 0.925758986775936 0.635110266737044 0.924607774726955 GO:0120013 lipid transfer activity 4/1239 65/18639 0.0615384615384615 0.925758986775936 0.635110266737044 0.924607774726955 GO:0160215 deacylase activity 4/1239 65/18639 0.0615384615384615 0.925758986775936 0.635110266737044 0.924607774726955 GO:0043425 bHLH transcription factor binding 2/1239 32/18639 0.0625 0.94022397094431 0.637374676083388 0.924607774726955 GO:0047498 calcium-dependent phospholipase A2 activity 2/1239 32/18639 0.0625 0.94022397094431 0.637374676083388 0.924607774726955 GO:0070717 poly-purine tract binding 2/1239 32/18639 0.0625 0.94022397094431 0.637374676083388 0.924607774726955 GO:0071813 lipoprotein particle binding 2/1239 32/18639 0.0625 0.94022397094431 0.637374676083388 0.924607774726955 GO:0071814 protein-lipid complex binding 2/1239 32/18639 0.0625 0.94022397094431 0.637374676083388 0.924607774726955 GO:0120015 sterol transfer activity 2/1239 32/18639 0.0625 0.94022397094431 0.637374676083388 0.924607774726955 GO:0160041 neuropeptide activity 2/1239 32/18639 0.0625 0.94022397094431 0.637374676083388 0.924607774726955 GO:0004559 alpha-mannosidase activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0005041 low-density lipoprotein particle receptor activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0008242 omega peptidase activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0010181 FMN binding 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0015116 sulfate transmembrane transporter activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0015250 water channel activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0031005 filamin binding 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0034483 heparan sulfate sulfotransferase activity 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0051371 muscle alpha-actinin binding 1/1239 15/18639 0.0666666666666667 1.00290556900726 0.643774261381872 0.924607774726955 GO:0008094 ATP-dependent activity, acting on DNA 13/1239 210/18639 0.0619047619047619 0.931269456935316 0.645348049606647 0.924607774726955 GO:0019956 chemokine binding 2/1239 33/18639 0.0606060606060606 0.911732335461149 0.654151870557281 0.924607774726955 GO:0005006 epidermal growth factor receptor activity 3/1239 50/18639 0.06 0.902615012106537 0.654715077635149 0.924607774726955 GO:0005007 fibroblast growth factor receptor activity 3/1239 50/18639 0.06 0.902615012106537 0.654715077635149 0.924607774726955 GO:0005017 platelet-derived growth factor receptor activity 3/1239 50/18639 0.06 0.902615012106537 0.654715077635149 0.924607774726955 GO:0005019 platelet-derived growth factor beta-receptor activity 3/1239 50/18639 0.06 0.902615012106537 0.654715077635149 0.924607774726955 GO:0140713 histone chaperone activity 10/1239 164/18639 0.0609756097560976 0.917291678970058 0.656907772221144 0.924607774726955 GO:0005126 cytokine receptor binding 17/1239 275/18639 0.0618181818181818 0.929966982170372 0.657528901649015 0.924607774726955 GO:0015294 solute:monoatomic cation symporter activity 7/1239 116/18639 0.0603448275862069 0.907802454704851 0.658479469069964 0.924607774726955 GO:0042054 histone methyltransferase activity 4/1239 67/18639 0.0597014925373134 0.898124390155759 0.658858149836482 0.924607774726955 GO:0003712 transcription coregulator activity 31/1239 495/18639 0.0626262626262626 0.942123413309854 0.662460569837099 0.924607774726955 GO:0004674 protein serine/threonine kinase activity 27/1239 433/18639 0.0623556581986143 0.938052552997556 0.664107501065204 0.924607774726955 GO:0008509 monoatomic anion transmembrane transporter activity 9/1239 149/18639 0.0604026845637584 0.908672830979736 0.664754360701356 0.924607774726955 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0004707 MAP kinase activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0005024 transforming growth factor beta receptor activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0008296 3'-5'-DNA exonuclease activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0015562 efflux transmembrane transporter activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0015923 mannosidase activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0016722 oxidoreductase activity, acting on metal ions 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0019841 retinol binding 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0022841 potassium ion leak channel activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0034450 ubiquitin-ubiquitin ligase activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0140327 flippase activity 1/1239 16/18639 0.0625 0.94022397094431 0.667472913129502 0.924607774726955 GO:0008175 tRNA methyltransferase activity 2/1239 34/18639 0.0588235294117647 0.884916678535821 0.670303081854985 0.924607774726955 GO:0008376 acetylgalactosaminyltransferase activity 2/1239 34/18639 0.0588235294117647 0.884916678535821 0.670303081854985 0.924607774726955 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1239 34/18639 0.0588235294117647 0.884916678535821 0.670303081854985 0.924607774726955 GO:0140223 general transcription initiation factor activity 4/1239 68/18639 0.0588235294117647 0.884916678535821 0.670332767014575 0.924607774726955 GO:0004175 endopeptidase activity 25/1239 405/18639 0.0617283950617284 0.928616267599318 0.679673637936179 0.924607774726955 GO:0000510 H3-H4 histone complex chaperone activity 9/1239 151/18639 0.0596026490066225 0.896637429244905 0.680173388024207 0.924607774726955 GO:0140584 chromatin extrusion motor activity 9/1239 151/18639 0.0596026490066225 0.896637429244905 0.680173388024207 0.924607774726955 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 9/1239 151/18639 0.0596026490066225 0.896637429244905 0.680173388024207 0.924607774726955 GO:0140849 ATP-dependent H2AZ histone chaperone activity 9/1239 151/18639 0.0596026490066225 0.896637429244905 0.680173388024207 0.924607774726955 GO:0005080 protein kinase C binding 3/1239 52/18639 0.0576923076923077 0.86789905010244 0.680865818286103 0.924607774726955 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/1239 52/18639 0.0576923076923077 0.86789905010244 0.680865818286103 0.924607774726955 GO:0030159 signaling receptor complex adaptor activity 3/1239 52/18639 0.0576923076923077 0.86789905010244 0.680865818286103 0.924607774726955 GO:0002039 p53 binding 4/1239 69/18639 0.0579710144927536 0.872091799136751 0.681538683195849 0.924607774726955 GO:0004623 phospholipase A2 activity 2/1239 35/18639 0.0571428571428571 0.859633344863369 0.685837329060982 0.924607774726955 GO:0016247 channel regulator activity 10/1239 168/18639 0.0595238095238095 0.895451400899343 0.686295430065611 0.924607774726955 GO:0015616 DNA translocase activity 9/1239 152/18639 0.0592105263157895 0.890738498789346 0.687719274949102 0.924607774726955 GO:0140674 ATP-dependent histone chaperone activity 9/1239 152/18639 0.0592105263157895 0.890738498789346 0.687719274949102 0.924607774726955 GO:0004549 tRNA-specific ribonuclease activity 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0004659 prenyltransferase activity 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0005092 GDP-dissociation inhibitor activity 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0008484 sulfuric ester hydrolase activity 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0016018 cyclosporin A binding 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0017110 nucleoside diphosphate phosphatase activity 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0030548 acetylcholine receptor regulator activity 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0032183 SUMO binding 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0046965 nuclear retinoid X receptor binding 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:1990226 histone methyltransferase binding 1/1239 17/18639 0.0588235294117647 0.884916678535821 0.689596151095058 0.924607774726955 GO:0008146 sulfotransferase activity 3/1239 53/18639 0.0566037735849057 0.851523596326922 0.693377134420951 0.925074939239834 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1239 53/18639 0.0566037735849057 0.851523596326922 0.693377134420951 0.925074939239834 GO:0017046 peptide hormone binding 3/1239 53/18639 0.0566037735849057 0.851523596326922 0.693377134420951 0.925074939239834 GO:0051018 protein kinase A binding 3/1239 53/18639 0.0566037735849057 0.851523596326922 0.693377134420951 0.925074939239834 GO:0061775 cohesin loader activity 9/1239 153/18639 0.0588235294117647 0.884916678535821 0.695154433717111 0.925422203846124 GO:0106310 protein serine kinase activity 22/1239 361/18639 0.0609418282548476 0.916783484134064 0.695354346118145 0.925422203846124 GO:0141108 transporter regulator activity 10/1239 170/18639 0.0588235294117647 0.884916678535821 0.700402225950011 0.928040397321451 GO:0004033 aldo-keto reductase (NADPH) activity 2/1239 36/18639 0.0555555555555556 0.835754640839387 0.700765197977422 0.928040397321451 GO:0004190 aspartic-type endopeptidase activity 2/1239 36/18639 0.0555555555555556 0.835754640839387 0.700765197977422 0.928040397321451 GO:0016409 palmitoyltransferase activity 2/1239 36/18639 0.0555555555555556 0.835754640839387 0.700765197977422 0.928040397321451 GO:0004197 cysteine-type endopeptidase activity 5/1239 88/18639 0.0568181818181818 0.854749064494827 0.703875704314727 0.928058203314766 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0004706 JUN kinase kinase kinase activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0005372 water transmembrane transporter activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0008409 5'-3' exonuclease activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0008525 phosphatidylcholine transporter activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0017128 phospholipid scramblase activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0030228 lipoprotein particle receptor activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0035615 clathrin adaptor activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0099602 neurotransmitter receptor regulator activity 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:1901611 phosphatidylglycerol binding 1/1239 18/18639 0.0555555555555556 0.835754640839387 0.71024862498579 0.928058203314766 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 21/1239 349/18639 0.0601719197707736 0.905201301539508 0.71407240890763 0.928766606752069 GO:0000149 SNARE binding 6/1239 106/18639 0.0566037735849057 0.851523596326922 0.7147610408492 0.928766606752069 GO:0023023 MHC protein complex binding 2/1239 37/18639 0.0540540540540541 0.813166677573457 0.715098593324877 0.928766606752069 GO:0042805 actinin binding 2/1239 37/18639 0.0540540540540541 0.813166677573457 0.715098593324877 0.928766606752069 GO:0070001 aspartic-type peptidase activity 2/1239 37/18639 0.0540540540540541 0.813166677573457 0.715098593324877 0.928766606752069 GO:0004521 RNA endonuclease activity 4/1239 73/18639 0.0547945205479452 0.824305947129258 0.723662696855829 0.934003830392004 GO:0005501 retinoid binding 2/1239 38/18639 0.0526315789473684 0.791767554479419 0.728850516919884 0.934003830392004 GO:0019840 isoprenoid binding 2/1239 38/18639 0.0526315789473684 0.791767554479419 0.728850516919884 0.934003830392004 GO:0042887 amide transmembrane transporter activity 2/1239 38/18639 0.0526315789473684 0.791767554479419 0.728850516919884 0.934003830392004 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1239 19/18639 0.0526315789473684 0.791767554479419 0.72952803820971 0.934003830392004 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1239 19/18639 0.0526315789473684 0.791767554479419 0.72952803820971 0.934003830392004 GO:0016918 retinal binding 1/1239 19/18639 0.0526315789473684 0.791767554479419 0.72952803820971 0.934003830392004 GO:0022840 leak channel activity 1/1239 19/18639 0.0526315789473684 0.791767554479419 0.72952803820971 0.934003830392004 GO:0022842 narrow pore channel activity 1/1239 19/18639 0.0526315789473684 0.791767554479419 0.72952803820971 0.934003830392004 GO:0034987 immunoglobulin receptor binding 1/1239 19/18639 0.0526315789473684 0.791767554479419 0.72952803820971 0.934003830392004 GO:0043395 heparan sulfate proteoglycan binding 1/1239 19/18639 0.0526315789473684 0.791767554479419 0.72952803820971 0.934003830392004 GO:1990380 K48-linked deubiquitinase activity 1/1239 19/18639 0.0526315789473684 0.791767554479419 0.72952803820971 0.934003830392004 GO:0004620 phospholipase activity 6/1239 109/18639 0.055045871559633 0.828087167070218 0.739495603222577 0.945642064381896 GO:0140098 catalytic activity, acting on RNA 23/1239 387/18639 0.0594315245478036 0.894063104153762 0.741817926225886 0.947487825203205 GO:0003689 DNA clamp loader activity 9/1239 160/18639 0.05625 0.846201573849879 0.744027143445419 0.948062955832343 GO:0099106 ion channel regulator activity 9/1239 160/18639 0.05625 0.846201573849879 0.744027143445419 0.948062955832343 GO:0004222 metalloendopeptidase activity 6/1239 110/18639 0.0545454545454545 0.820559101915034 0.747390675623501 0.949155013039196 GO:0015095 magnesium ion transmembrane transporter activity 1/1239 20/18639 0.05 0.752179176755448 0.747525608599515 0.949155013039196 GO:0016004 phospholipase activator activity 1/1239 20/18639 0.05 0.752179176755448 0.747525608599515 0.949155013039196 GO:0051213 dioxygenase activity 5/1239 93/18639 0.0537634408602151 0.808794813715535 0.748670764359167 0.949432452926547 GO:0017116 single-stranded DNA helicase activity 3/1239 58/18639 0.0517241379310345 0.778116389747015 0.750386317155304 0.949432452926547 GO:0061980 regulatory RNA binding 3/1239 58/18639 0.0517241379310345 0.778116389747015 0.750386317155304 0.949432452926547 GO:0030331 nuclear estrogen receptor binding 2/1239 40/18639 0.05 0.752179176755448 0.75466627386563 0.953364696058148 GO:0042562 hormone binding 5/1239 94/18639 0.0531914893617021 0.800190613569626 0.756997167995128 0.953364696058148 GO:0036002 pre-mRNA binding 3/1239 59/18639 0.0508474576271186 0.764927976361473 0.760706529441427 0.953364696058148 GO:0070888 E-box binding 3/1239 59/18639 0.0508474576271186 0.764927976361473 0.760706529441427 0.953364696058148 GO:0035173 histone kinase activity 21/1239 360/18639 0.0583333333333333 0.877542372881356 0.763971295709567 0.953364696058148 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1239 21/18639 0.0476190476190476 0.716361120719474 0.764326498601405 0.953364696058148 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/1239 21/18639 0.0476190476190476 0.716361120719474 0.764326498601405 0.953364696058148 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1239 21/18639 0.0476190476190476 0.716361120719474 0.764326498601405 0.953364696058148 GO:0035613 RNA stem-loop binding 1/1239 21/18639 0.0476190476190476 0.716361120719474 0.764326498601405 0.953364696058148 GO:0140312 cargo adaptor activity 1/1239 21/18639 0.0476190476190476 0.716361120719474 0.764326498601405 0.953364696058148 GO:0005085 guanyl-nucleotide exchange factor activity 13/1239 230/18639 0.0565217391304348 0.850289504158332 0.766055246091359 0.953364696058148 GO:0001727 lipid kinase activity 2/1239 41/18639 0.0487804878048781 0.733833343176047 0.766759917887212 0.953364696058148 GO:0004812 aminoacyl-tRNA ligase activity 2/1239 41/18639 0.0487804878048781 0.733833343176047 0.766759917887212 0.953364696058148 GO:0016875 ligase activity, forming carbon-oxygen bonds 2/1239 41/18639 0.0487804878048781 0.733833343176047 0.766759917887212 0.953364696058148 GO:0140828 metal cation:monoatomic cation antiporter activity 2/1239 41/18639 0.0487804878048781 0.733833343176047 0.766759917887212 0.953364696058148 GO:0035402 histone H3T11 kinase activity 14/1239 247/18639 0.0566801619433198 0.852672750977836 0.76875604184828 0.953696955647395 GO:0016798 hydrolase activity, acting on glycosyl bonds 7/1239 130/18639 0.0538461538461538 0.810039113428944 0.768796525470859 0.953696955647395 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 10/1239 181/18639 0.0552486187845304 0.831137211884473 0.770674829674527 0.954905191393867 GO:0042578 phosphoric ester hydrolase activity 21/1239 363/18639 0.0578512396694215 0.870289956576551 0.776534291512924 0.954905191393867 GO:0004402 histone acetyltransferase activity 2/1239 42/18639 0.0476190476190476 0.716361120719474 0.778331414698973 0.954905191393867 GO:0004520 DNA endonuclease activity 2/1239 42/18639 0.0476190476190476 0.716361120719474 0.778331414698973 0.954905191393867 GO:0031492 nucleosomal DNA binding 2/1239 42/18639 0.0476190476190476 0.716361120719474 0.778331414698973 0.954905191393867 GO:0033691 sialic acid binding 1/1239 22/18639 0.0454545454545455 0.683799251595862 0.780010216951006 0.954905191393867 GO:0019905 syntaxin binding 3/1239 61/18639 0.0491803278688525 0.739848370579129 0.780307527522883 0.954905191393867 GO:0004725 protein tyrosine phosphatase activity 5/1239 98/18639 0.0510204081632653 0.767529772199437 0.788232795199633 0.954905191393867 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/1239 23/18639 0.0434782608695652 0.654068849352563 0.794650993724799 0.954905191393867 GO:0005212 structural constituent of eye lens 1/1239 23/18639 0.0434782608695652 0.654068849352563 0.794650993724799 0.954905191393867 GO:0005283 amino acid:sodium symporter activity 1/1239 23/18639 0.0434782608695652 0.654068849352563 0.794650993724799 0.954905191393867 GO:0016493 C-C chemokine receptor activity 1/1239 23/18639 0.0434782608695652 0.654068849352563 0.794650993724799 0.954905191393867 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/1239 23/18639 0.0434782608695652 0.654068849352563 0.794650993724799 0.954905191393867 GO:0070577 lysine-acetylated histone binding 1/1239 23/18639 0.0434782608695652 0.654068849352563 0.794650993724799 0.954905191393867 GO:0141003 histone H2AX kinase activity 20/1239 354/18639 0.0564971751412429 0.849919973734969 0.805554208395106 0.954905191393867 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0004622 lysophospholipase activity 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0005315 phosphate transmembrane transporter activity 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0019957 C-C chemokine binding 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0030215 semaphorin receptor binding 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0030552 cAMP binding 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0060229 lipase activator activity 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0140033 acetylation-dependent protein binding 1/1239 24/18639 0.0416666666666667 0.62681598062954 0.808318130530502 0.954905191393867 GO:0001540 amyloid-beta binding 4/1239 83/18639 0.0481927710843374 0.724991977595613 0.810531942249074 0.954905191393867 GO:0005254 chloride channel activity 4/1239 83/18639 0.0481927710843374 0.724991977595613 0.810531942249074 0.954905191393867 GO:0140996 histone H3 kinase activity 20/1239 357/18639 0.0560224089635854 0.842777789081735 0.816773890300223 0.954905191393867 GO:0030276 clathrin binding 2/1239 46/18639 0.0434782608695652 0.654068849352563 0.819716558912059 0.954905191393867 GO:0004709 MAP kinase kinase kinase activity 1/1239 25/18639 0.04 0.601743341404358 0.821076327483105 0.954905191393867 GO:0005251 delayed rectifier potassium channel activity 1/1239 25/18639 0.04 0.601743341404358 0.821076327483105 0.954905191393867 GO:0015271 outward rectifier potassium channel activity 1/1239 25/18639 0.04 0.601743341404358 0.821076327483105 0.954905191393867 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1239 25/18639 0.04 0.601743341404358 0.821076327483105 0.954905191393867 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 13/1239 243/18639 0.0534979423868313 0.804800765252743 0.827561793396277 0.954905191393867 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/1239 122/18639 0.0491803278688525 0.739848370579129 0.828818138141046 0.954905191393867 GO:0140938 histone H3 methyltransferase activity 2/1239 47/18639 0.0425531914893617 0.6401524908557 0.828918533312633 0.954905191393867 GO:0016500 protein-hormone receptor activity 3/1239 67/18639 0.0447761194029851 0.673593292616819 0.831274484975255 0.954905191393867 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0004435 phosphatidylinositol phospholipase C activity 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0004950 chemokine receptor activity 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0019865 immunoglobulin binding 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0030507 spectrin binding 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0034237 protein kinase A regulatory subunit binding 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0051139 metal cation:proton antiporter activity 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0052742 phosphatidylinositol kinase activity 1/1239 26/18639 0.0384615384615385 0.57859936673496 0.832985988504296 0.954905191393867 GO:0004676 3-phosphoinositide-dependent protein kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0004711 ribosomal protein S6 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0035175 histone H3S10 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0035979 histone H2AXS139 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0044022 histone H3S28 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0044023 histone H4S1 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0044024 histone H2AS1 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0044025 histone H2BS14 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0072354 histone H3T3 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0072371 histone H2AS121 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0072518 Rho-dependent protein serine/threonine kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0140823 histone H2BS36 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0140855 histone H3S57 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0140995 histone H2A kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0140997 histone H4 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0140998 histone H2B kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:1990244 histone H2AT120 kinase activity 13/1239 245/18639 0.0530612244897959 0.798230963087414 0.835843989139194 0.954905191393867 GO:0032266 phosphatidylinositol-3-phosphate binding 2/1239 48/18639 0.0416666666666667 0.62681598062954 0.837694996879165 0.954905191393867 GO:0140693 molecular condensate scaffold activity 2/1239 48/18639 0.0416666666666667 0.62681598062954 0.837694996879165 0.954905191393867 GO:0004677 DNA-dependent protein kinase activity 13/1239 246/18639 0.0528455284552846 0.794986121774051 0.839870455179195 0.954905191393867 GO:0140857 histone H3T45 kinase activity 13/1239 246/18639 0.0528455284552846 0.794986121774051 0.839870455179195 0.954905191393867 GO:0035403 histone H3T6 kinase activity 13/1239 247/18639 0.0526315789473684 0.791767554479419 0.843821255919802 0.954905191393867 GO:0042393 histone binding 13/1239 247/18639 0.0526315789473684 0.791767554479419 0.843821255919802 0.954905191393867 GO:0008395 steroid hydroxylase activity 1/1239 27/18639 0.037037037037037 0.557169760559591 0.844103506381219 0.954905191393867 GO:0035255 ionotropic glutamate receptor binding 1/1239 27/18639 0.037037037037037 0.557169760559591 0.844103506381219 0.954905191393867 GO:0005004 GPI-linked ephrin receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0005008 hepatocyte growth factor receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0005009 insulin receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0005011 macrophage colony-stimulating factor receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0005020 stem cell factor receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0008288 boss receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0016763 pentosyltransferase activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0036332 placental growth factor receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0038062 protein tyrosine kinase collagen receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0060175 brain-derived neurotrophic factor receptor activity 2/1239 49/18639 0.0408163265306122 0.614023817759549 0.846061804358891 0.954905191393867 GO:0004679 AMP-activated protein kinase activity 13/1239 248/18639 0.0524193548387097 0.788574943372647 0.847696993530459 0.954905191393867 GO:0016758 hexosyltransferase activity 10/1239 197/18639 0.050761421319797 0.763633681985226 0.850713513386614 0.954905191393867 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/1239 89/18639 0.0449438202247191 0.676116113937481 0.851002075424753 0.954905191393867 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/1239 89/18639 0.0449438202247191 0.676116113937481 0.851002075424753 0.954905191393867 GO:0031267 small GTPase binding 15/1239 283/18639 0.0530035335689046 0.797363084899768 0.851165907145362 0.954905191393867 GO:0016782 transferase activity, transferring sulphur-containing groups 3/1239 70/18639 0.0428571428571429 0.644725008647527 0.852713759592043 0.954905191393867 GO:0032813 tumor necrosis factor receptor superfamily binding 2/1239 50/18639 0.04 0.601743341404358 0.854034584639047 0.954905191393867 GO:0016866 intramolecular transferase activity 1/1239 28/18639 0.0357142857142857 0.537270840539606 0.854481528925474 0.954905191393867 GO:0045499 chemorepellent activity 1/1239 28/18639 0.0357142857142857 0.537270840539606 0.854481528925474 0.954905191393867 GO:0046966 nuclear thyroid hormone receptor binding 1/1239 28/18639 0.0357142857142857 0.537270840539606 0.854481528925474 0.954905191393867 GO:0050698 proteoglycan sulfotransferase activity 1/1239 28/18639 0.0357142857142857 0.537270840539606 0.854481528925474 0.954905191393867 GO:0051393 alpha-actinin binding 1/1239 28/18639 0.0357142857142857 0.537270840539606 0.854481528925474 0.954905191393867 GO:0051959 dynein light intermediate chain binding 1/1239 28/18639 0.0357142857142857 0.537270840539606 0.854481528925474 0.954905191393867 GO:0141052 histone H3 demethylase activity 1/1239 28/18639 0.0357142857142857 0.537270840539606 0.854481528925474 0.954905191393867 GO:0016757 glycosyltransferase activity 14/1239 267/18639 0.052434456928839 0.788802132927062 0.854808450552024 0.954905191393867 GO:0140793 histone H2AXY142 phosphatase activity 4/1239 90/18639 0.0444444444444444 0.668603712671509 0.856982228183841 0.955592324465271 GO:0140097 catalytic activity, acting on DNA 18/1239 336/18639 0.0535714285714286 0.805906260809409 0.858795578616364 0.955592324465271 GO:0005125 cytokine activity 12/1239 234/18639 0.0512820512820513 0.77146582231328 0.859760499281128 0.955592324465271 GO:0031490 chromatin DNA binding 6/1239 128/18639 0.046875 0.705167978208232 0.860870814878192 0.955592324465271 GO:0005010 insulin-like growth factor receptor activity 2/1239 51/18639 0.0392156862745098 0.589944452357214 0.861628700723788 0.955592324465271 GO:0005021 vascular endothelial growth factor receptor activity 2/1239 51/18639 0.0392156862745098 0.589944452357214 0.861628700723788 0.955592324465271 GO:0005030 neurotrophin receptor activity 2/1239 51/18639 0.0392156862745098 0.589944452357214 0.861628700723788 0.955592324465271 GO:0005416 amino acid:monoatomic cation symporter activity 1/1239 29/18639 0.0344827586206897 0.518744259831343 0.864169207484462 0.956954120181747 GO:0015085 calcium ion transmembrane transporter activity 7/1239 147/18639 0.0476190476190476 0.716361120719474 0.86463201582284 0.956954120181747 GO:0035591 signaling adaptor activity 6/1239 129/18639 0.0465116279069767 0.69970155977251 0.865699591833642 0.957152984611965 GO:0016298 lipase activity 6/1239 130/18639 0.0461538461538462 0.694319240081952 0.870388449883454 0.961351177227831 GO:0032452 histone demethylase activity 1/1239 30/18639 0.0333333333333333 0.501452784503632 0.873212428974347 0.961353007993873 GO:0051721 protein phosphatase 2A binding 1/1239 30/18639 0.0333333333333333 0.501452784503632 0.873212428974347 0.961353007993873 GO:0070566 adenylyltransferase activity 1/1239 30/18639 0.0333333333333333 0.501452784503632 0.873212428974347 0.961353007993873 GO:0005003 ephrin receptor activity 2/1239 53/18639 0.0377358490566038 0.567682397551281 0.875740866280133 0.961353007993873 GO:0005005 transmembrane-ephrin receptor activity 2/1239 53/18639 0.0377358490566038 0.567682397551281 0.875740866280133 0.961353007993873 GO:0038064 collagen receptor activity 2/1239 53/18639 0.0377358490566038 0.567682397551281 0.875740866280133 0.961353007993873 GO:0008327 methyl-CpG binding 1/1239 31/18639 0.032258064516129 0.485276888229321 0.881654032526434 0.96391789763032 GO:0017147 Wnt-protein binding 1/1239 31/18639 0.032258064516129 0.485276888229321 0.881654032526434 0.96391789763032 GO:0070273 phosphatidylinositol-4-phosphate binding 1/1239 31/18639 0.032258064516129 0.485276888229321 0.881654032526434 0.96391789763032 GO:0140457 protein demethylase activity 1/1239 31/18639 0.032258064516129 0.485276888229321 0.881654032526434 0.96391789763032 GO:0003724 RNA helicase activity 3/1239 77/18639 0.038961038961039 0.586113644225024 0.893702331124959 0.974644254603133 GO:0004518 nuclease activity 10/1239 209/18639 0.0478468899521531 0.719788685890381 0.894891896869917 0.974644254603133 GO:1990782 protein tyrosine kinase binding 5/1239 117/18639 0.0427350427350427 0.642888185261067 0.895773015105385 0.974644254603133 GO:0030296 protein tyrosine kinase activator activity 1/1239 33/18639 0.0303030303030303 0.455866167730575 0.896889703679321 0.974644254603133 GO:0071889 14-3-3 protein binding 1/1239 33/18639 0.0303030303030303 0.455866167730575 0.896889703679321 0.974644254603133 GO:0140416 transcription regulator inhibitor activity 1/1239 33/18639 0.0303030303030303 0.455866167730575 0.896889703679321 0.974644254603133 GO:0008186 ATP-dependent activity, acting on RNA 3/1239 79/18639 0.0379746835443038 0.571275324118062 0.903366825103125 0.97914465347997 GO:0015020 glucuronosyltransferase activity 1/1239 34/18639 0.0294117647058824 0.442458339267911 0.903755964946725 0.97914465347997 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1239 34/18639 0.0294117647058824 0.442458339267911 0.903755964946725 0.97914465347997 GO:0140767 enzyme-substrate adaptor activity 6/1239 139/18639 0.0431654676258993 0.649363318062257 0.906732138196348 0.980742559199362 GO:0005343 organic acid:sodium symporter activity 1/1239 35/18639 0.0285714285714286 0.429816672431684 0.910165336590424 0.980742559199362 GO:0043015 gamma-tubulin binding 1/1239 35/18639 0.0285714285714286 0.429816672431684 0.910165336590424 0.980742559199362 GO:0004879 nuclear receptor activity 2/1239 59/18639 0.0338983050847458 0.509951984240982 0.910483606857636 0.980742559199362 GO:0015459 potassium channel regulator activity 2/1239 59/18639 0.0338983050847458 0.509951984240982 0.910483606857636 0.980742559199362 GO:0015108 chloride transmembrane transporter activity 5/1239 121/18639 0.0413223140495868 0.621635683268965 0.911146880898052 0.980742559199362 GO:0030971 receptor tyrosine kinase binding 3/1239 81/18639 0.037037037037037 0.557169760559591 0.912230161135588 0.980742559199362 GO:0008528 G protein-coupled peptide receptor activity 5/1239 122/18639 0.040983606557377 0.616540308815941 0.914665203238095 0.980742559199362 GO:0098531 ligand-modulated transcription factor activity 2/1239 60/18639 0.0333333333333333 0.501452784503632 0.915304481831894 0.980742559199362 GO:0000993 RNA polymerase II complex binding 1/1239 36/18639 0.0277777777777778 0.417877320419693 0.916148197693652 0.980742559199362 GO:0005484 SNAP receptor activity 1/1239 36/18639 0.0277777777777778 0.417877320419693 0.916148197693652 0.980742559199362 GO:0045505 dynein intermediate chain binding 1/1239 36/18639 0.0277777777777778 0.417877320419693 0.916148197693652 0.980742559199362 GO:0030165 PDZ domain binding 3/1239 83/18639 0.036144578313253 0.543743983196709 0.920348207218675 0.98379017408154 GO:0019213 deacetylase activity 1/1239 37/18639 0.027027027027027 0.406583338786729 0.921732908926118 0.98379017408154 GO:0030551 cyclic nucleotide binding 1/1239 37/18639 0.027027027027027 0.406583338786729 0.921732908926118 0.98379017408154 GO:0015103 inorganic anion transmembrane transporter activity 7/1239 165/18639 0.0424242424242424 0.638212634822804 0.927888077959577 0.988566719361668 GO:0008013 beta-catenin binding 4/1239 106/18639 0.0377358490566038 0.567682397551281 0.928042226339525 0.988566719361668 GO:0004519 endonuclease activity 5/1239 127/18639 0.0393700787401575 0.592267068311376 0.930476867966136 0.990181701547379 GO:0001653 peptide receptor activity 5/1239 128/18639 0.0390625 0.587639981840194 0.933306382319304 0.991207737309107 GO:0008081 phosphoric diester hydrolase activity 3/1239 87/18639 0.0344827586206897 0.518744259831343 0.934559851806812 0.991207737309107 GO:0008234 cysteine-type peptidase activity 8/1239 187/18639 0.0427807486631016 0.64357576620787 0.935236771139075 0.991207737309107 GO:0032451 demethylase activity 1/1239 40/18639 0.025 0.376089588377724 0.936354226335249 0.991207737309107 GO:0071949 FAD binding 1/1239 40/18639 0.025 0.376089588377724 0.936354226335249 0.991207737309107 GO:0003730 mRNA 3'-UTR binding 12/1239 262/18639 0.0458015267175573 0.689019093211097 0.93695796318922 0.991207737309107 GO:0042169 SH2 domain binding 1/1239 41/18639 0.024390243902439 0.366916671588023 0.94059408404645 0.994078845688307 GO:0043175 RNA polymerase core enzyme binding 1/1239 42/18639 0.0238095238095238 0.358180560359737 0.944551710128096 0.996581587520372 GO:1990841 promoter-specific chromatin binding 2/1239 68/18639 0.0294117647058824 0.442458339267911 0.945952157686381 0.996581587520372 GO:0140030 modification-dependent protein binding 7/1239 173/18639 0.0404624277456647 0.608699911825218 0.946474850154288 0.996581587520372 GO:0008375 acetylglucosaminyltransferase activity 1/1239 43/18639 0.0232558139534884 0.349850779886255 0.948245877528821 0.996581587520372 GO:0016279 protein-lysine N-methyltransferase activity 2/1239 69/18639 0.0289855072463768 0.436045899568376 0.948940389944433 0.996581587520372 GO:0004842 ubiquitin-protein transferase activity 22/1239 449/18639 0.0489977728285078 0.737102088579949 0.950486915684395 0.996581587520372 GO:0001223 transcription coactivator binding 1/1239 44/18639 0.0227272727272727 0.341899625797931 0.951694111436209 0.996581587520372 GO:0016278 lysine N-methyltransferase activity 2/1239 70/18639 0.0285714285714286 0.429816672431684 0.951770584954797 0.996581587520372 GO:0001221 transcription coregulator binding 4/1239 115/18639 0.0347826086956522 0.523255079482051 0.95220689716696 0.996581587520372 GO:0101005 deubiquitinase activity 4/1239 115/18639 0.0347826086956522 0.523255079482051 0.95220689716696 0.996581587520372 GO:0008009 chemokine activity 1/1239 45/18639 0.0222222222222222 0.334301856335755 0.95491277214772 0.998444198230108 GO:0042379 chemokine receptor binding 2/1239 72/18639 0.0277777777777778 0.417877320419693 0.956987666542234 0.999180225098234 GO:0140101 catalytic activity, acting on a tRNA 5/1239 139/18639 0.0359712230215827 0.541136098385214 0.95826139034423 0.999180225098234 GO:0004896 cytokine receptor activity 3/1239 96/18639 0.03125 0.470111985472155 0.958397358767694 0.999180225098234 GO:0031491 nucleosome binding 2/1239 74/18639 0.027027027027027 0.406583338786729 0.961661714274161 0.999999692549552 GO:0016755 aminoacyltransferase activity 24/1239 496/18639 0.0483870967741935 0.727915332343982 0.963217814256955 0.999999692549552 GO:0019787 ubiquitin-like protein transferase activity 23/1239 479/18639 0.0480167014613779 0.722343259514626 0.963806625446642 0.999999692549552 GO:0003714 transcription corepressor activity 8/1239 204/18639 0.0392156862745098 0.589944452357214 0.965238212027289 0.999999692549552 GO:0001222 transcription corepressor binding 1/1239 49/18639 0.0204081632653061 0.307011908879775 0.965782309535061 0.999999692549552 GO:0035254 glutamate receptor binding 1/1239 49/18639 0.0204081632653061 0.307011908879775 0.965782309535061 0.999999692549552 GO:0008194 UDP-glycosyltransferase activity 5/1239 145/18639 0.0344827586206897 0.518744259831343 0.967946668257522 0.999999692549552 GO:0048020 CCR chemokine receptor binding 1/1239 50/18639 0.02 0.300871670702179 0.968062875349265 0.999999692549552 GO:0015370 solute:sodium symporter activity 2/1239 79/18639 0.0253164556962025 0.380850216078708 0.971309139151709 0.999999692549552 GO:0019783 ubiquitin-like protein peptidase activity 4/1239 127/18639 0.031496062992126 0.473813654649101 0.97288979890205 0.999999692549552 GO:0004497 monooxygenase activity 3/1239 106/18639 0.0283018867924528 0.425761798163461 0.975232917709875 0.999999692549552 GO:0004843 cysteine-type deubiquitinase activity 3/1239 108/18639 0.0277777777777778 0.417877320419693 0.97771173655577 0.999999692549552 GO:0016779 nucleotidyltransferase activity 4/1239 136/18639 0.0294117647058824 0.442458339267911 0.982526959479537 0.999999692549552 GO:0060589 nucleoside-triphosphatase regulator activity 22/1239 490/18639 0.0448979591836735 0.675426199535504 0.983433151079805 0.999999692549552 GO:0030695 GTPase regulator activity 21/1239 489/18639 0.0429447852760736 0.646043464697931 0.990056942568886 0.999999692549552 GO:0005249 voltage-gated potassium channel activity 2/1239 98/18639 0.0204081632653061 0.307011908879775 0.990699002252929 0.999999692549552 GO:0030527 structural constituent of chromatin 2/1239 98/18639 0.0204081632653061 0.307011908879775 0.990699002252929 0.999999692549552 GO:0005244 voltage-gated monoatomic ion channel activity 5/1239 173/18639 0.0289017341040462 0.434785651303727 0.99125174265591 0.999999692549552 GO:0042826 histone deacetylase binding 3/1239 127/18639 0.0236220472440945 0.355360240986826 0.992014138806523 0.999999692549552 GO:0022832 voltage-gated channel activity 5/1239 175/18639 0.0285714285714286 0.429816672431684 0.992056068769517 0.999999692549552 GO:0005262 calcium channel activity 3/1239 131/18639 0.0229007633587786 0.344509546605549 0.993598339110759 0.999999692549552 GO:0140375 immune receptor activity 4/1239 156/18639 0.0256410256410256 0.38573291115664 0.993651828316389 0.999999692549552 GO:0035064 methylated histone binding 1/1239 74/18639 0.0135135135135135 0.203291669393364 0.993906346245204 0.999999692549552 GO:0140034 methylation-dependent protein binding 1/1239 76/18639 0.0131578947368421 0.197941888619855 0.994692587856999 0.999999692549552 GO:0061659 ubiquitin-like protein ligase activity 13/1239 372/18639 0.0349462365591398 0.525716628915098 0.997346150534426 0.999999692549552 GO:0061630 ubiquitin protein ligase activity 12/1239 353/18639 0.0339943342776204 0.5113966074258 0.997511953992816 0.999999692549552 GO:0003823 antigen binding 4/1239 174/18639 0.0229885057471264 0.345829506554229 0.997538040978111 0.999999692549552 GO:0005096 GTPase activator activity 8/1239 271/18639 0.029520295202952 0.444091026866685 0.997879972651279 0.999999692549552 GO:0005267 potassium channel activity 2/1239 124/18639 0.0161290322580645 0.242638444114661 0.998101986419276 0.999999692549552 GO:0015081 sodium ion transmembrane transporter activity 3/1239 164/18639 0.0182926829268293 0.275187503691018 0.999020181671049 0.999999692549552 GO:0046873 metal ion transmembrane transporter activity 15/1239 450/18639 0.0333333333333333 0.501452784503632 0.999369384585363 0.999999692549552 GO:0022843 voltage-gated monoatomic cation channel activity 2/1239 143/18639 0.013986013986014 0.210399769721804 0.999420626309482 0.999999692549552 GO:0005216 monoatomic ion channel activity 14/1239 448/18639 0.03125 0.470111985472155 0.999711211064504 0.999999692549552 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 6/1239 268/18639 0.0223880597014925 0.33679664630841 0.999751923362591 0.999999692549552 GO:0015079 potassium ion transmembrane transporter activity 2/1239 160/18639 0.0125 0.188044794188862 0.999802358060419 0.999999692549552 GO:0001217 DNA-binding transcription repressor activity 6/1239 278/18639 0.0215827338129496 0.324681659031129 0.999852834872469 0.999999692549552 GO:0022836 gated channel activity 6/1239 318/18639 0.0188679245283019 0.283841198775641 0.999982798019668 0.999999692549552 GO:0015276 ligand-gated monoatomic ion channel activity 1/1239 186/18639 0.00537634408602151 0.0808794813715536 0.999997400966893 0.999999692549552 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 11/1239 484/18639 0.0227272727272727 0.341899625797931 0.999997686285032 0.999999692549552 GO:0022834 ligand-gated channel activity 1/1239 188/18639 0.00531914893617021 0.0800190613569625 0.999997738275245 0.999999692549552 GO:0045182 translation regulator activity 6/1239 356/18639 0.0168539325842697 0.253543542726555 0.999997918455365 0.999999692549552 GO:0001216 DNA-binding transcription activator activity 11/1239 491/18639 0.0224032586558045 0.337025293047248 0.999998371657855 0.999999692549552 GO:0005261 monoatomic cation channel activity 5/1239 341/18639 0.0146627565982405 0.220580403740601 0.999999056504184 0.999999692549552 GO:0030371 translation repressor activity 4/1239 329/18639 0.0121580547112462 0.182900711673057 0.999999692549552 0.999999692549552