category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	103/1218	222/9376	3.57153212325626	RPS26/RPS10/RPSA/RPL22/RPL27/RPS5/RPL35/RPL36/RPL38/RPL29/UBA52/RPL10A/RPL39/RPLP0/RPS13/RPL37/RPL5/RPL21/RPL6/RPL37A/RPS19/RPS11/RPL14/RPL24/RPL12/RPL34/RPL7A/RPL18A/RPS16/RPL9/RPS6/RPS29/RPS27/RPL26/RPL23/RPS15/RPS4X/RPL23A/RPL32/RPS3/RPS28/RPL3/RPS7/RPL15/RPS3A/RPS27A/RPL8/RPLP2/RPL18/RPL11/RPS8/RPS12/RPS24/RPL13A/RPS14/RPL28/RPS18/RPS2/RPL10/RPLP1/RPL13/RPL27A/RPL41/RPL4/RPL19/RPS21/RPS20/RPS25/MRPL23/RPS9/RPL7/RPL35A/MRPS15/FAU/RPL17/RPL30/RPL31/RPS27L/MRPL52/RPL36A/MRPS33/MRPL11/RPL22L1/MRPS16/MRPL41/MRPL51/MRPS12/MRPL33/MRPL12/MRPL20/MRPL21/MRPL15/MRPL42/MRPS31/MRPS11/MRPL13/MRPS18C/MRPL39/MRPS35/MRPS25/MRPL37/MRPS26/MRPS24	14.9823665781333
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	93/1218	238/9376	3.00798940265762	ISG15/RPS26/RPS10/RPSA/RPL22/RPL27/RPS5/RPL35/RPL36/RPL38/RPL29/UBA52/RPL10A/RPL39/RPLP0/RPS13/RPL37/RPL5/RPL21/RPL6/RPL37A/RPS19/RPS11/RPL14/RPL24/RPL12/RPL34/RPL7A/RPL18A/RPS16/RPL9/RPS6/RPS29/RPS27/RPL26/RPL23/RPS15/RPS4X/RPL23A/RPL32/RPS3/RPS28/RPL3/RPS7/RPL15/RPS3A/RPS27A/RPL8/RPLP2/RPL18/RPL11/RPS8/RPS12/RPS24/RPL13A/RPS14/RPL28/RPS18/RPS2/RPL10/RPLP1/RPL13/RPL27A/RPL41/RPL4/RPL19/RPS21/RPS20/RPS25/RPS9/RPL7/RPL35A/FAU/RPL17/PIK3CB/RPL30/RPL31/RPS27L/IL1B/TNF/MX1/RPL36A/EGFR/RPL22L1/IFNAR2/F13A1/MAPK13/OAS1/OAS3/STAT1/NLRP3/MAPK9/MASP1	12.1238833731204
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	90/1218	268/9376	2.58510403646791	TUBA1C/TXN/CALM1/TUBA1B/UQCRH/PSMA7/UBA52/RPS27A/MT-CO3/MT-CO2/MT-CO1/TUBB/GNAS/NDUFB2/CALM3/SLC25A5/NDUFS5/NDUFA4/COX5A/COX5B/VDAC1/COX7B/SLC39A8/TUBB4B/COX6B1/PSMA4/CYCS/COX7A2/PSMB3/HSPA5/COX6C/PSMB6/SOD1/COX8C/NDUFA6/UQCR10/MT-ND6/COX8A/PSMB1/UBE2L3/COX7C/TUBB6/UBC/PSMD14/PSMB2/TXN2/SLC25A4/NDUFB11/COX4I1/NDUFC1/PSMA3/SLC39A10/PARK7/MT-ATP6/PSMA1/PSMD11/UQCRC1/COX6A1/UQCRQ/NDUFB1/NDUFB3/PSMB5/TP53/NDUFB4/NDUFS7/NDUFA1/NDUFA3/PSMC4/PPIF/NDUFV2/NDUFA12/MAOB/MAPT/PSMD4/TH/PSMD2/NDUFA2/NDUFA11/VDAC2/NDUFS6/MAP3K5/MAPK9/PSMD12/PSMD1/XBP1/ADRM1/COX4I2/NDUFV3/UBA1/UQCRFS1	10.1725794344191
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	61/1218	158/9376	2.97196067427407	CCNE1/CCNB1/CDKN1C/PTTG1/YWHAB/WEE1/CDK7/YWHAE/CDC20/YWHAZ/ANAPC11/CCNB2/MAD2L1/CDK1/CCNA2/RBX1/AURKB/MCM7/YWHAG/SKP2/MCM4/SFN/CDC6/ANAPC15/SMC1A/CDT1/ORC6/CHEK1/DBF4/SKP1/PLK1/MCM5/TFDP2/CDCA5/MCM3/PCNA/TTK/PKMYT1/TP53/NDC80/ORC1/CDC45/PRKDC/TFDP1/E2F3/GADD45A/BUB1/DDX11/ORC2/TICRR/CDC25C/BUB1B/ESCO2/YWHAQ/MCM2/BUB3/FBXO5/CCNE2/TRIP13/CDC25A/MCM6	9.65886004424329
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	84/1218	275/9376	2.35134796238245	TUBA1C/HSPA8/TUBA1B/UQCRH/PSMA7/MT-CO3/MT-CO2/MT-CO1/TUBB/NDUFB2/SLC25A5/NDUFS5/NDUFA4/COX5A/EGR1/COX5B/VDAC1/COX7B/PIK3CB/RAC1/TUBB4B/COX6B1/PSMA4/CYCS/COX7A2/PSMB3/HSPA5/COX6C/PSMB6/IL1B/SOD1/COX8C/TNF/NDUFA6/UQCR10/MT-ND6/COX8A/PSMB1/COX7C/TUBB6/STIP1/PPP3CA/PSMD14/PSMB2/SLC25A4/NDUFB11/COX4I1/NCF1/NDUFC1/PSMA3/MT-ATP6/PSMA1/PSMD11/UQCRC1/COX6A1/NCF4/UQCRQ/NDUFB1/NDUFB3/MAPK13/PSMB5/NDUFB4/NDUFS7/NDUFA1/CYBA/NDUFA3/PSMC4/IL1A/PPIF/NDUFV2/NDUFA12/PSMD4/PSMD2/NDUFA2/NDUFA11/VDAC2/NDUFS6/MAPK9/PSMD12/PSMD1/ADRM1/COX4I2/NDUFV3/UQCRFS1	8.78833114318906
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	88/1218	308/9376	2.19939010086793	TUBA1C/PPARG/TUBA1B/UQCRH/PSMA7/MT-CO3/MT-CO2/MT-CO1/TUBB/NDUFB2/SLC25A5/NDUFS5/NDUFA4/COX5A/COX5B/GPX1/VDAC1/COX7B/POLR2F/TUBB4B/COX6B1/POLR2H/PSMA4/CYCS/GPX3/COX7A2/PSMB3/COX6C/PSMB6/SOD1/COX8C/NDUFA6/CLTA/POLR2L/TGM2/UQCR10/MT-ND6/COX8A/PSMB1/POLR2J/COX7C/TUBB6/PSMD14/PSMB2/SLC25A4/NDUFB11/COX4I1/NDUFC1/PSMA3/POLR2I/MT-ATP6/PSMA1/PSMD11/UQCRC1/COX6A1/UQCRQ/NDUFB1/NDUFB3/PSMB5/TP53/TAF4B/NDUFB4/SOD2/HAP1/NDUFS7/NDUFA1/NDUFA3/PSMC4/PPIF/NDUFV2/NDUFA12/TBPL1/DNAH14/PSMD4/PSMD2/NDUFA2/NDUFA11/VDAC2/SLC1A2/NDUFS6/MAP3K5/MAPK9/PSMD12/PSMD1/ADRM1/COX4I2/NDUFV3/UQCRFS1	8.26984737498361
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	100/1218	388/9376	1.98398591573138	TUBA1C/CALM1/TUBA1B/UQCRH/PSMA7/GAPDH/MT-CO3/MT-CO2/MT-CO1/TUBB/CTNNB1/NDUFB2/CALM3/SLC25A5/NDUFS5/NDUFA4/COX5A/COX5B/WNT7A/VDAC1/COX7B/PIK3CB/SLC39A8/TUBB4B/COX6B1/PSMA4/CYCS/COX7A2/PSMB3/COX6C/PSMB6/IL1B/COX8C/TNF/NDUFA6/HSD17B10/UQCR10/MT-ND6/COX8A/PSMB1/NOS2/APP/COX7C/TUBB6/PPP3CA/PSMD14/PSMB2/IRS2/FRAT2/SLC25A4/NDUFB11/COX4I1/NDUFC1/PSMA3/SLC39A10/WNT10B/MT-ATP6/PSMA1/PSMD11/UQCRC1/COX6A1/UQCRQ/WNT4/INSR/NDUFB1/NDUFB3/PSMB5/CHRM5/WNT5A/BACE2/NDUFB4/NDUFS7/NDUFA1/NDUFA3/PSMC4/IL1A/PPIF/NDUFV2/NDUFA12/WNT6/MAPT/PSMD4/PSMD2/NDUFA2/NDUFA11/VDAC2/NDUFS6/MAP3K5/MAPK9/PSMD12/PSMD1/XBP1/ADRM1/COX4I2/NDUFV3/HRAS/UQCRFS1/CSNK1A1/FZD3/PPID	7.64875314873444
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	54/1218	157/9376	2.64767343352891	LEP/PPARG/UQCRH/MT-CO3/MT-CO2/MT-CO1/NDUFB2/NDUFS5/CDC42/NDUFA4/COX5A/COX5B/COX7B/PIK3CB/RAC1/COX6B1/CYCS/COX7A2/COX6C/IL1B/CEBPA/COX8C/TNF/NDUFA6/UQCR10/COX8A/COX7C/IRS2/NDUFB11/COX4I1/NDUFC1/UQCRC1/COX6A1/UQCRQ/INSR/NDUFB1/NDUFB3/MAPK13/NDUFB4/NDUFS7/NDUFA1/NDUFA3/IL1A/NDUFV2/NDUFA12/NDUFA2/NDUFA11/NDUFS6/MAP3K5/MAPK9/XBP1/COX4I2/NDUFV3/UQCRFS1	8.04445246813487
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	64/1218	205/9376	2.40323601265569	SLC2A1/UQCRH/GAPDH/MT-CO3/MT-CO2/MT-CO1/PPP1CB/NDUFB2/SLC25A5/NDUFS5/NDUFA4/COX5A/COX5B/VDAC1/COX7B/PIK3CB/RAC1/COX6B1/COX7A2/COX6C/PRKCZ/COX8C/REN/NDUFA6/UQCR10/MT-ND6/COX8A/COX7C/PDK3/SLC25A4/NDUFB11/COX4I1/NCF1/NDUFC1/MT-ATP6/UQCRC1/COX6A1/NCF4/UQCRQ/INSR/GYS1/NDUFB1/NDUFB3/MAPK13/PPP1CA/NDUFB4/NDUFS7/NDUFA1/CYBA/NDUFA3/PPIF/NDUFV2/NDUFA12/NDUFA2/NDUFA11/VDAC2/NDUFS6/PPP1CC/MAPK9/PDHA1/PARP1/COX4I2/NDUFV3/UQCRFS1	7.84904352855851
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	95/1218	368/9376	1.9872206753766	TUBA1C/TUBA1B/UQCRH/PSMA7/PFN1/ACTB/MT-CO3/MT-CO2/CHCHD10/MT-CO1/TUBB/NDUFB2/HNRNPA1/NDUFS5/NDUFA4/COX5A/COX5B/GPX1/VDAC1/COX7B/RAC1/TUBB4B/COX6B1/PSMA4/CYCS/ACTG1/GPX3/COX7A2/PSMB3/HSPA5/COX6C/PSMB6/SOD1/COX8C/TNF/NDUFA6/UQCR10/SRSF3/MT-ND6/COX8A/PSMB1/NOS2/HNRNPA3/COX7C/TUBB6/PPP3CA/PSMD14/ALYREF/PSMB2/NDUFB11/COX4I1/NDUFC1/PSMA3/MT-ATP6/PSMA1/PSMD11/UQCRC1/COX6A1/UQCRQ/NDUFB1/NDUFB3/CHMP2B/MAPK13/PSMB5/TP53/HNRNPA2B1/NDUFB4/HAP1/NDUFS7/NDUFA1/NUP155/NDUFA3/PSMC4/NDUFV2/NUP210/NDUFA12/DNAH14/PSMD4/PSMD2/NDUFA2/NDUFA11/SLC1A2/NDUFS6/MAP3K5/NUP50/PSMD12/PSMD1/XBP1/ADRM1/NRG4/COX4I2/NDUFV3/NUP37/UQCRFS1/TOMM40	7.46519909361904
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	48/1218	138/9376	2.67751838366531	UQCRH/MT-CO3/MT-CO2/MT-CO1/NDUFB2/NDUFS5/NDUFA4/COX5A/COX5B/COX7B/COX6B1/CYCS/PPA1/ATP6V1C2/COX7A2/COX6C/COX8C/NDUFA6/UQCR10/MT-ND6/COX8A/ATP6V1F/COX7C/COX17/ATP6V1B1/NDUFB11/COX4I1/NDUFC1/MT-ATP6/UQCRC1/COX6A1/UQCRQ/NDUFB1/NDUFB3/PPA2/NDUFB4/NDUFS7/NDUFA1/NDUFA3/NDUFV2/NDUFA12/NDUFA2/NDUFA11/NDUFS6/COX4I2/NDUFV3/ATP6V0E2/UQCRFS1	7.6707050594882
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	65/1218	235/9376	2.1291967997764	PPARG/UQCRH/RPS6/ACTB/MT-CO3/MT-CO2/MT-CO1/GNAS/NDUFB2/GRB2/NDUFS5/NDUFA4/COX5A/COX5B/COX20/ACSL4/COX7B/COX6B1/ACTG1/COX7A2/COX6C/COX8C/NDUFA6/UQCR10/MT-ND6/COX8A/COX7C/COX17/KDM1A/SMARCA2/NDUFB11/COX4I1/NDUFC1/MT-ATP6/UQCRC1/COX6A1/UQCRQ/NDUFB1/NDUFB3/MAPK13/RPS6KA1/SMARCC1/COA4/NDUFB4/NDUFS7/NDUFA1/ADCY1/NDUFA3/NDUFV2/NPR1/NDUFA12/NDUFA2/NDUFA11/COA6/NDUFS6/MAP3K5/NDUFAF4/NPPB/MGLL/COX16/COX14/COX4I2/NDUFV3/HRAS/UQCRFS1	6.77367175207628
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	109/1218	480/9376	1.74805692391899	TUBA1C/CALM1/TUBA1B/UQCRH/PSMA7/UBA52/RPS27A/MT-CO3/MT-CO2/MT-CO1/TUBB/CTNNB1/NDUFB2/CALM3/SLC25A5/NDUFS5/NDUFA4/COX5A/COX5B/WNT7A/GPX1/VDAC1/COX7B/RAC1/TUBB4B/COX6B1/PSMA4/CYCS/GPX3/COX7A2/PSMB3/HSPA5/COX6C/PSMB6/IL1B/SOD1/COX8C/TNF/NDUFA6/HSD17B10/UQCR10/MT-ND6/COX8A/PSMB1/UBE2L3/NOS2/APP/COX7C/TUBB6/UBC/PPP3CA/PSMD14/PSMB2/FRAT2/SLC25A4/NDUFB11/COX4I1/NDUFC1/PSMA3/WNT10B/PARK7/MT-ATP6/PSMA1/PSMD11/UQCRC1/COX6A1/UQCRQ/WNT4/NDUFB1/NDUFB3/CHMP2B/MAPK13/PSMB5/CHRM5/WNT5A/NDUFB4/HAP1/NDUFS7/NDUFA1/NDUFA3/PSMC4/IL1A/PPIF/NDUFV2/NDUFA12/WNT6/MAPT/DNAH14/PSMD4/PSMD2/NDUFA2/NDUFA11/VDAC2/NDUFS6/MAP3K5/MAPK9/PSMD12/PSMD1/XBP1/ADRM1/COX4I2/NDUFV3/UBA1/HRAS/UQCRFS1/CSNK1A1/FZD3/TOMM40/PPID	6.50092731722191
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	20/1218	36/9376	4.27659186279876	RPA3/MCM7/RNASEH2A/MCM4/SSBP1/RFC3/RNASEH2C/MCM5/LIG1/FEN1/MCM3/PCNA/DNA2/POLA2/POLE2/PRIM1/MCM2/RFC4/RFC2/MCM6	7.61057714397401
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	63/1218	227/9376	2.13641197022634	MGST3/MGST1/UQCRH/MT-CO3/MT-CO2/MT-CO1/NDUFB2/SLC25A5/GRB2/NDUFS5/NDUFA4/COX5A/COX5B/VDAC1/COX7B/PIK3CB/RAC1/COX6B1/COX7A2/COX6C/SOD1/COX8C/NDUFA6/UQCR10/EGFR/HMOX1/MT-ND6/COX8A/ACP1/COX7C/SLC25A4/NDUFB11/COX4I1/NCF1/NDUFC1/MT-ATP6/UQCRC1/COX6A1/UQCRQ/NDUFB1/NDUFB3/MAPK13/NDUFB4/SOD2/NDUFS7/NDUFA1/CYBA/NDUFA3/GSTO2/PPIF/NDUFV2/NDUFA12/GSTA3/NDUFA2/NDUFA11/VDAC2/NDUFS6/MAP3K5/MAPK9/COX4I2/NDUFV3/HRAS/UQCRFS1	6.69698531009989
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	53/1218	200/9376	2.03993431855501	TUBA1C/CLDN7/CLDN4/EZR/ARPC1B/TUBA1B/GAPDH/RPS3/ACTB/TUBB/ARPC3/ARPC2/ITGB1/CDC42/CLDN19/ARPC5/BAIAP2L1/RAC1/MYH9/TUBB4B/CLDN10/NCL/CYCS/ACTG1/CLDN6/ACTR3/ARPC4/IL1B/TNFSF10/TNF/CYFIP2/TMED10/PAK1/CLDN3/TUBB6/ACTR2/TMBIM6/MYO1B/MAPK13/PAK3/PAK2/CLDN5/WASF1/ARF6/ARPC5L/NLRP3/ARPC1A/PTPN6/CTTN/HCLS1/MAPK9/LPAR2/PYCARD	5.7439630527711
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	20/1218	46/9376	3.34689797958164	PSMA7/POMP/PSMA4/PSMB3/PSMB6/PSMB1/PSMD14/PSMB2/PSMA3/PSMA1/PSME2/PSMD11/PSMB5/PSME3/PSMC4/PSMD4/PSMD2/PSMD12/PSMD1/ADRM1	6.16523644345203
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	26/1218	78/9376	2.56595511767926	ARPC1B/ACTB/ITGA5/ARPC3/CTNNB1/ARPC2/ITGB1/CDC42/CDH1/ARPC5/PIK3CB/RAC1/ACTG1/ACTR3/ARPC4/CLTA/PXN/ACTR2/DNM2/WASF1/ARHGAP10/ARPC5L/ARPC1A/CTTN/HCLS1/CD2AP	5.36598275640644
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	43/1218	170/9376	1.94710711870955	TUBA1C/CLDN7/CLDN4/EZR/ARPC1B/TUBA1B/ACTB/ARPC3/ARPC2/VASP/ITGB1/CDC42/CLDN19/ARPC5/RAC1/MYH9/CLDN10/ACTG1/CLDN6/TIAM1/ACTR3/ARPC4/PRKCZ/CLDN3/ACTN1/TJP2/MARVELD2/F11R/ACTR2/PARD6B/RAB8B/PCNA/MYL12B/HSPA4/CRB3/CLDN5/TJP3/ARPC5L/ARPC1A/CTTN/HCLS1/MAP3K5/MAPK9	4.81510218620186
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	26/1218	87/9376	2.30051148481588	TPM1/UQCRH/MT-CO3/MT-CO2/MT-CO1/TPM3/COX5A/COX5B/COX7B/TPM4/TPM2/COX6B1/COX7A2/COX6C/COX8C/UQCR10/COX8A/MYL4/COX7C/COX4I1/UQCRC1/COX6A1/UQCRQ/ATP1A4/COX4I2/UQCRFS1	4.70876230948746
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	20/1218	59/9376	2.60944588238568	RRM2/MGST3/MGST1/PRDX6/GSTP1/GPX4/SMS/GPX1/GGCT/SRM/GPX3/IDH2/IDH1/ODC1/RRM1/HPGDS/LAP3/GSTO2/GSTA3/GCLC	4.79161336998313
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	36/1218	142/9376	1.95157149795324	TXN/MGST3/MGST1/CALM1/GSTP1/ACTB/HSP90AB1/CTNNB1/CALM3/HSP90AA1/SDC4/CTSL/CDH5/PIK3CB/RAC1/RAC3/ACTG1/IL1R2/PRKCZ/IL1B/TNF/HMOX1/TXN2/NCF1/MAPK13/TP53/CYBA/GSTO2/IL1A/KDR/GSTA3/MAP3K5/MAPK9/ITGAV/ASS1/TRPV4	4.41477011744415
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	35/1218	138/9376	1.95235715475596	CCNE1/CCNB1/CALM1/PTTG1/YWHAB/PPP1CB/YWHAE/CALM3/CDC20/YWHAZ/ANAPC11/AURKA/CCNB2/MAD2L1/CDK1/RBX1/YWHAG/ANAPC15/PPP3CA/SMC1A/SKP1/PLK1/PKMYT1/PGR/MAPK13/RPS6KA1/PPP1CA/ADCY1/CPEB4/BUB1/CDC25C/PPP1CC/YWHAQ/FBXO5/CCNE2	4.35479629705435
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	30/1218	116/9376	1.99082724647528	CLDN7/CLDN4/EZR/ACTB/CTNNB1/VASP/ITGB1/CDC42/CLDN19/CDH5/PIK3CB/RAC1/CLDN10/ACTG1/CLDN6/CLDN3/PXN/PTK2B/ACTN1/F11R/NCF1/NCF4/VAV3/MYL12B/MAPK13/CLDN5/CYBA/CXCL12/ESAM/VAV2	4.14895642628233
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	24/1218	85/9376	2.17351492321066	RRM2/PNP/ADK/AK5/TYMS/NME1/ADA/TK1/DTYMK/UPP1/APRT/NME1-NME2/RRM1/UCK2/NME2/CTPS1/AK2/AK4/ITPA/DCTPP1/CDA/DUT/HDDC2/NT5E	4.19937135458657
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	22/1218	75/9376	2.25804050355775	PKM/ENO1/TPI1/ALDOA/GAPDH/PGK1/PFKP/TALDO1/TKT/PGAM1/IDH2/CBS/IDH1/ARG2/PRPS2/SHMT1/RPIA/ASNS/PSAT1/ASL/CTH/ASS1	4.22647072492055
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	12/1218	30/9376	3.07914614121511	ABCG2/FOLR1/TYMS/IL1B/TNF/ATIC/SHMT1/SLC19A1/GGH/DHFR/FOLR2/GART	4.40707242239781
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/1218	39/9376	2.76333628057766	GCSH/GLDC/TYMS/CBS/ATIC/MTHFD1L/ALDH7A1/AHCY/SHMT1/MTHFD2/DHFR/GART/CTH/MTHFD1	4.26364658951261
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	52/1218	248/9376	1.61406854176598	TUBA1C/TXN/ARPC1B/TUBA1B/PFN1/GAPDH/RPS3/ACTB/ANXA2/TUBB/HSP90AB1/ARPC3/CTNNB1/HSP90AA1/ARPC2/CDC42/ARPC5/PIK3CB/RAC1/TUBB4B/TCF7L2/CYCS/ACTG1/ACTR3/ARPC4/IL1B/TNFSF10/TNF/CYFIP2/PAK1/TUBB6/TXN2/ACTR2/SKP1/DYNLL2/DNM2/DYNLL1/MYL12B/PIK3C2G/CD14/MAPK13/PODXL/PAK3/FBXO22/ARF6/ARPC5L/NLRP3/ARPC1A/MAPK9/RIPK2/HRAS/PYCARD	3.78679945519225
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	49/1218	232/9376	1.62584225128815	EZR/ARPC1B/CFL1/PFN1/ACTB/ITGA5/ARPC3/PPP1CB/ARPC2/ITGB1/CDC42/ARPC5/PIK3CB/RAC1/MYH9/RAC3/ACTG1/TIAM1/ACTR3/ARPC4/ITGA6/DIAPH3/CYFIP2/EGFR/PAK1/PXN/ACTN1/ACTR2/DIAPH1/ITGB4/ITGAE/VAV3/MYL12B/SSH2/IQGAP1/PAK3/CHRM5/PAK2/PPP1CA/IQGAP3/WASF1/ARPC5L/CXCL12/ARPC1A/PPP1CC/ITGAV/LPAR2/VAV2/HRAS	3.72956512477243
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	52/1218	253/9376	1.58216995398405	ARPC1B/PFN1/UBA52/RPS27A/ACTB/ITGA5/ARPC3/BNIP3/ARPC2/ITGB1/CDC42/ARPC5/VDAC1/PIK3CB/RAC1/CBX3/CYCS/ACTG1/RBX1/ACTR3/HK2/ARPC4/IL1B/TNF/EGFR/PXN/UBC/PLCD4/ACTN1/ACTR2/SKP1/UBE2N/DIAPH1/HK1/MYL12B/CD14/MAPK13/TP53/FOXO1/FNBP1L/WASF1/ARF6/FOXO4/ARPC5L/NLRP3/ARPC1A/CTTN/HCLS1/MAPK9/RIPK2/PYCARD/PPID	3.62709259407074
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	43/1218	204/9376	1.62258926559129	EZR/RPS6/ACTB/ITGA5/CTNNB1/PPP1CB/SDC4/ITGB1/GRB2/ERBB3/CDC42/CTSL/WNT7A/PIK3CB/RAC1/ACTG1/TIAM1/TNF/EGFR/PAK1/PXN/DDX5/WNT10B/HSPG2/VAV3/WNT4/MAPK13/IQGAP1/TP53/WNT5A/PPP1CA/WNT6/KDR/PTPN6/CTTN/HCLS1/HPSE/PPP1CC/ITGAV/EIF4B/VAV2/HRAS/FZD3	3.47377848518109
NA	NA	hsa04517	IgSF CAM signaling	58/1218	299/9376	1.49323140627488	TUBA1C/EZR/ARPC1B/TUBA1B/ACTB/TUBB/ITGA5/ARPC3/CTNNB1/ARPC2/ITGB1/GRB2/CDC42/CDH1/ARPC5/PIK3CB/PTPRF/RAC1/MYH9/TUBB4B/ACTG1/IL1RAP/ACTR3/ARPC4/PAK1/APP/EPB41L3/TUBB6/PXN/ACTN1/TJP2/F11R/ACTR2/DYNLL2/PARD6B/DYNLL1/VAV3/MYL12B/MAPK13/IQGAP1/PTPRS/PAK3/ICAM3/PAK2/GRIP1/FOXO1/ARF6/KDR/ARPC5L/ARPC1A/PTPN6/MAPK9/CD2AP/ESAM/CNTNAP2/MTSS1/RASA1/VAV2	3.34913443522375
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	15/1218	50/9376	2.30935960591133	SAT1/SMS/SRM/GATM/ODC1/ARG2/NOS2/ALDH7A1/CKMT1A/CKMT1B/CNDP2/ALDH1B1/LAP3/MAOB/ALDH4A1	3.58685373348936
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	13/1218	41/9376	2.44078657535344	GCSH/GLDC/PGAM1/CBS/GATM/ALAS2/ALDH7A1/SHMT1/GCAT/PSAT1/ALAS1/MAOB/CTH	3.57233231614132
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	18/1218	67/9376	2.06808322917433	PKM/ENO1/TPI1/ALDOA/GAPDH/PGK1/LDHB/PFKP/LDHA/PGAM1/HK2/ALDH7A1/PGM1/HK1/ALDH1B1/ALDH3B2/PGM2/PDHA1	3.39006803391632
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	41/1218	203/9376	1.55474127819975	PGF/ACTB/ITGA5/CTNNB1/PPP1CB/VASP/ITGB1/GRB2/CDC42/COL4A1/PIK3CB/RAC1/FLT4/RAC3/ACTG1/ITGA6/LAMA4/EGFR/PAK1/COL4A2/PXN/ACTN1/COL6A3/RAPGEF1/DIAPH1/ITGB4/VAV3/MYL12B/FLNB/PAK3/PAK2/PPP1CA/LAMC2/RELN/KDR/LAMA1/PPP1CC/MAPK9/ITGAV/VAV2/HRAS	3.08745215985765
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	16/1218	59/9376	2.08755670590855	RRM2/TYMS/NME1/TK1/DTYMK/UPP1/NME1-NME2/RRM1/UCK2/NME2/CTPS1/DCTPP1/CDA/DUT/HDDC2/NT5E	3.23785428865847
NA	NA	hsa04519	Cadherin signaling	72/1218	404/9376	1.37189679559089	KRT19/KRT7/DSP/DSC2/KRT8/KRT18/ARPC1B/ACTB/YWHAB/ARPC3/CTNNB1/PPP1CB/KRT23/YWHAE/LIMA1/PKP3/ARPC2/VASP/CDC42/CDH1/YWHAZ/CDH5/WNT7A/DSG2/ARPC5/RAC1/FLT4/RAC3/TCF7L2/ACTG1/ACTR3/ARPC4/CYFIP2/YWHAG/EGFR/KRT10/JUP/TEAD1/PTK2B/ACTN1/ACTR2/FAT2/WNT10B/MYO1B/WWTR1/FMN1/VAV3/WNT4/MAPK13/WNT5A/TMC6/PPP1CA/TMC4/DSC3/WASF1/WNT6/KDR/KRT15/ARPC5L/TMC5/ARPC1A/PPP1CC/MAPK9/YWHAQ/KRT14/VAV2/CDH13/HRAS/CDH3/CSNK1A1/FZD3/TAOK3	2.95247288814128
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	30/1218	138/9376	1.67344898979082	ARPC1B/ACTB/ITGA5/ARPC3/ARPC2/ITGB1/CDC42/ARPC5/PIK3CB/RAC1/RAC3/ACTG1/ACTR3/ARPC4/IL1B/TNF/SKAP2/PXN/PTK2B/ACTR2/VAV3/MAPK13/RPS6KA1/ARF6/ARPC5L/NLRP3/ARPC1A/MAPK9/VAV2/PYCARD	3.07944677304133
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	31/1218	144/9376	1.65717934683452	PSMA7/SLC25A5/VDAC1/PIK3CB/PSMA4/CYCS/PSMB3/PSMB6/PSMB1/PSMD14/PSMB2/SLC25A4/PSMA3/PSMA1/PSMD11/SLC1A6/PSMB5/RELN/PSMC4/PPIF/TBPL1/PSMD4/PSMD2/NOP56/VDAC2/MAP3K5/MAPK9/PSMD12/PSMD1/XBP1/ADRM1	3.0706808913449
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/1218	116/9376	1.72538361361191	GCSH/PKM/ENO1/TPI1/ALDOA/GAPDH/PGK1/GLDC/PFKP/TALDO1/TKT/PGP/PGAM1/IDH2/HK2/ACAT2/IDH1/PRPS2/SHMT1/RPIA/PCCA/MDH2/HK1/PSAT1/PDHA1/ACOX1	3.03744675564906
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1218	71/9376	1.95157149795324	SLC2A1/PKM/SLC16A3/LDHB/PFKP/PIK3CB/LDHA/PGAM1/IDH2/HK2/SLC7A5/IDH1/EGFR/HK1/TP53/PDK1/PDHA1/HRAS	3.10978126489523
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	8/1218	23/9376	2.67751838366531	RPA3/SSBP1/RFC3/LIG1/PCNA/EXO1/RFC4/RFC2	3.11224065035622
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1218	75/9376	1.84748768472906	CCNE1/PERP/CCNB1/RRM2/CCNB2/CYCS/CDK1/SFN/GTSE1/PMAIP1/TP53I3/CHEK1/PPP1R13L/RPRM/TP53/SIVA1/GADD45A/CCNE2	2.84719123041628
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/1218	98/9376	1.72809222211052	ARPC1B/CFL1/ARPC3/ARPC2/VASP/CDC42/ARPC5/PIK3CB/RAC1/ACTR3/ARPC4/PAK1/ACTR2/NCF1/DNM2/MARCKSL1/VAV3/WASF1/ARF6/ARPC5L/ARPC1A/VAV2	2.7995593399586
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	24/1218	110/9376	1.6795342588446	CCNB1/HSP90AB1/HSP90AA1/ANAPC11/AURKA/CCNB2/PIK3CB/MAD2L1/CDK1/CCNA2/ANAPC15/PLK1/STK10/PKMYT1/PGR/MAPK13/RPS6KA1/ADCY1/CPEB4/BUB1/KIF22/CDC25C/MAPK9/CDC25A	2.76999498737917
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	41/1218	216/9376	1.46116888645624	PPARG/HSPA8/CALM1/HSP90AB1/CCL3L1/CALM3/HSP90AA1/CDC42/HSPD1/CCL3/PIK3CB/RAC1/CYCS/LDLR/HSPA5/IL1B/TNFSF10/TNF/CCL3L3/PPP3CA/CYP2J2/NCF1/IRF7/NCF4/VAV3/CD14/HSPA4/MAPK13/TP53/SOD2/CYBA/NLRP3/HSPA2/CASP6/CXCL2/MAP3K5/MAPK9/XBP1/VAV2/HRAS/PYCARD	2.6494551354942
NA	NA	hsa04518	Integrin signaling	31/1218	154/9376	1.54957029833877	PGF/ACTB/ITGA5/CTNNB1/ITGB1/CDC42/CDH1/COL4A1/PIK3CB/RAC1/FLT4/RAC3/ACTG1/ITGA6/LAMA4/EGFR/COL4A2/PXN/ACTN1/COL6A3/ITGB4/ITGAE/FERMT1/FLNB/ICAM3/LAMC2/RELN/KDR/LAMA1/ITGAV/LIMS1	2.65698123049494
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/1218	44/9376	2.09941782355575	HMGB1/RFC3/LIG1/FEN1/PCNA/APEX1/SMUG1/POLE2/PARP1/RFC4/UNG/RFC2	2.8243543177679
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	28/1218	137/9376	1.57328634952597	TUBA1C/TUBA1B/ACTB/CTSV/BIRC5/CTSL/LMNB1/PIK3CB/CYCS/ACTG1/CSF2RB/TNFSF10/TNF/LMNB2/PMAIP1/CTSH/ENDOG/BCL2A1/TP53/CTSW/GADD45A/GZMB/CASP6/MCL1/MAP3K5/MAPK9/PARP1/HRAS	2.61178144894167
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	31/1218	157/9376	1.51996067480364	HLA-G/CCNE1/CCNB1/CALM1/PPP1CB/CALM3/SLC25A5/VDAC1/CCNB2/PIK3CB/CDK1/CCNA2/PPP3CA/MYBL2/CHEK1/SLC25A4/MAPK13/TP53/PPP1CA/E2F3/FOXO1/GADD45A/IL1A/FOXM1/VDAC2/PPP1CC/HRAS/CCNE2/TRPV4/CDC25A/PPID	2.53860919806096
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	26/1218	128/9376	1.5636288998358	RRM2/PNP/ADK/AK5/NME1/ADA/PAICS/ATIC/PRPS2/PDE6H/APRT/NME1-NME2/RRM1/PGM1/NME2/AK2/AK4/PPAT/ADCY1/PDE4D/NPR1/ITPA/GART/HDDC2/PGM2/NT5E	2.48080003535955
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/1218	110/9376	1.60955366472608	SLC2A1/ENO1/ALDOA/GAPDH/RPS6/PGK1/LDHB/PFKP/PIK3CB/EGLN3/LDHA/RBX1/HK2/EGFR/HMOX1/NOS2/ANGPT4/HK1/INSR/EIF4E/PDK1/EIF4E2/PDHA1	2.48473211446424
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	15/1218	63/9376	1.83282508405661	CDK7/RPA3/POLR2F/POLR2H/RBX1/POLR2L/POLR2J/RFC3/LIG1/POLR2I/PCNA/POLE2/RFC4/RFC2/DDB1	2.56269370694138
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	30/1218	154/9376	1.49958415968268	RFK/GCH1/AK5/NME1/UGP2/ALAS2/CPOX/MTHFD1L/SHMT1/NME1-NME2/GGH/NME2/KMO/TPK1/MTHFD2/KYNU/DHFR/CTPS1/PSAT1/VKORC1/AK2/AK4/ALDH1B1/RDH13/ALAS1/HMBS/PDXK/MMAB/GCLC/MTHFD1	2.41531563722032
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	39/1218	212/9376	1.41611673947393	PGF/EFNA1/CALM1/PFN1/ACTB/GNAS/CTNNB1/CALM3/VASP/ITGB1/ID1/CDC42/CDH1/PIK3CB/RAC1/FLT4/RAC3/ACTG1/CSF1R/TIAM1/PRKCZ/EGFR/RAPGEF1/PARD6B/ANGPT4/VAV3/INSR/MAPK13/APBB1IP/ADCY1/KDR/FPR1/RASGRP2/EFNA3/RALB/EFNA4/LPAR2/VAV2/HRAS	2.3678708380976
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/1218	93/9376	1.65545491463178	ACTB/CTNNB1/ARHGAP29/CDC42/CDH1/CDH5/PTPRF/RAC1/RAC3/TCF7L2/ACTG1/EGFR/SNAI1/ACP1/ACTN1/MYL12B/INSR/IQGAP1/WASF1/PTPN6	2.45446902124653
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	20/1218	93/9376	1.65545491463178	CCNE1/CKS2/CKS1B/ITGB1/COL4A1/PIK3CB/CYCS/ITGA6/SKP2/LAMA4/COL4A2/NOS2/TRAF4/TP53/LAMC2/E2F3/GADD45A/LAMA1/ITGAV/CCNE2	2.45446902124653
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	36/1218	193/9376	1.43587125756145	CCL4/CCL3L1/GRB2/CDC42/CCL3/PIK3CB/RAC1/CCR7/RAC3/TIAM1/PRKCZ/CCR1/CCL3L3/PAK1/GNG5/GNG4/CCL4L2/PXN/PTK2B/CCL21/NCF1/CCL4L1/CXCR6/VAV3/CXCL13/ADCY1/STAT1/CCL8/CCL20/CXCL12/CXCL2/RASGRP2/VAV2/PREX1/HRAS/GNG2	2.36407922052257
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1218	37/9376	2.08050414946967	HK2/UGP2/CMAS/GNPNAT1/PGM1/HK1/NANS/GALE/PGM2/NAGK	2.54445365646905
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/1218	32/9376	2.16502463054187	AKR1B1/PFKP/B4GALT1/HK2/UGP2/PGM1/HK1/GALE/PGM2	2.55071016728442
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	27/1218	138/9376	1.50610409081174	CALM1/RPS6/PYGL/PPP1CB/CALM3/GRB2/PIK3CB/CBLB/PTPRF/HK2/PRKCZ/SH2B2/FASN/RAPGEF1/IRS2/FLOT2/HK1/INSR/GYS1/EIF4E/PPP1R3B/PPP1CA/FOXO1/EIF4E2/PPP1CC/MAPK9/HRAS	2.31423705863352
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	30/1218	157/9376	1.47092968529384	ACTB/YWHAB/CTNNB1/PPP1CB/YWHAE/BIRC5/ID1/CDH1/YWHAZ/WNT7A/TCF7L2/ACTG1/PRKCZ/YWHAG/TEAD1/RASSF6/PARD6B/AREG/WNT10B/WWTR1/WNT4/WNT5A/BMP7/PPP1CA/DLG5/WNT6/PPP1CC/GDF7/YWHAQ/FZD3	2.29922470805774
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	13/1218	54/9376	1.8531898072128	LDHB/SMS/SRM/LDHA/DNMT1/ADI1/CBS/AHCY/MDH2/PSAT1/MTAP/CTH/GCLC	2.42943576625882
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/1218	13/9376	2.96071744347606	XRCC5/FEN1/PRKDC/XRCC4/DCLRE1C	2.73335857887113
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/1218	23/9376	2.34282858570715	HMGCS1/ACAT2/FDPS/IDI1/HMGCR/PDSS1/NUS1	2.49130248085075
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/1218	156/9376	1.43101343101343	CLDN7/CLDN4/YWHAB/CTNNB1/YWHAE/GRB2/CLDN19/YWHAZ/PIK3CB/CLDN10/CYCS/CLDN6/LDLR/TNF/MX1/YWHAG/EGFR/CLDN3/IFNAR2/IRF7/OAS1/TP53/OAS3/CLDN5/E2F3/PSME3/STAT1/YWHAQ/HRAS	2.09751499442233
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/1218	100/9376	1.53957307060755	CCL4/CCL3L1/CCL3/IL2RB/CCR7/CSF1R/TNFSF10/CCR1/TNF/CCL3L3/CCL4L2/IL10RA/CCL21/CCL4L1/CXCL13/IL20RA/CCL8/CCL20/CXCL12/CXCL2	2.09598093666546
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	17/1218	82/9376	1.59589891465417	RRM2/MGST3/MGST1/GSTP1/NME1/TK1/UPP1/NME1-NME2/RRM1/UCK2/NME2/TPMT/GSTO2/ITPA/CDA/DUT/GSTA3	2.09409132843082
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	39/1218	224/9376	1.3402533427164	HLA-G/CCNE1/SLC2A1/CALR/RAN/PTTG1/RANBP1/SLC25A5/EGR1/CDC20/ANAPC11/VDAC1/CCNB2/PIK3CB/IL2RB/MAD2L1/CCNA2/IL1R2/TNF/FDPS/HLA-DRB5/ANAPC15/IL15/PPP3CA/CHEK1/MSX2/SLC25A4/TP53/CANX/E2F3/ADCY1/TBPL1/VDAC2/MAPK9/BUB1B/BUB3/NFYB/HRAS/CCNE2	1.99152533580488
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/1218	15/9376	2.56595511767926	AK5/ACP1/TPK1/AK2/AK4	2.34520736404483
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/1218	20/9376	2.30935960591133	FDFT1/SQLE/MSMO1/EBP/DHCR24/DHCR7	2.26488555435038
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	40/1218	233/9376	1.32152194901936	DSP/DSC2/TNNI2/TPM1/ENO1/ACTB/ITGA5/TPM3/SDC4/ITGB1/CSRP1/COL4A1/DSG2/LMNB1/TPM4/TPM2/MYH9/ACTG1/ITGA6/DIAPH3/LMNB2/JUP/COL4A2/MYL4/NID2/COL6A3/HSPG2/FHL2/DIAPH1/ITGB4/COL27A1/DAG1/INF2/CAPZB/ATP1A4/LAMA1/TMOD1/PDLIM2/ITGAV/CAPZA1	1.92026717565963
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1218	42/9376	1.83282508405661	SAT1/FTH1/GPX4/ACSL4/SLC39A8/HMOX1/CP/TP53/VDAC2/GCLC	2.09007550791295
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1218	31/9376	1.98654589755813	ALDOA/PFKP/TALDO1/TKT/PRPS2/RPIA/PGM1/PGM2	2.12581722085368
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/1218	31/9376	1.98654589755813	SEC11C/SEC61G/SPCS3/HSPA5/SRP14/SEC11A/SRP19/SEC61B	2.12581722085368
NA	NA	hsa04981	Folate transport and metabolism	8/1218	31/9376	1.98654589755813	ABCG2/FOLR1/TYMS/SHMT1/SLC19A1/DHFR/FOLR2/MTHFD1	2.12581722085368
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	31/1218	174/9376	1.37145876979408	HSPA8/PDIA6/CALR/HSP90AB1/HSP90AA1/PDIA4/SSR4/MAN1A2/SSR3/SEC61G/EDEM2/ERP29/RBX1/HSPA5/DNAJA1/TUSC3/P4HB/BCAP31/SVIP/SKP1/EDEM1/SEC61B/HYOU1/CANX/HSPH1/STT3B/RPN2/MAP3K5/MAPK9/TMEM258/XBP1	1.91100383072919
NA	NA	hsa03272	Virion - Hepatitis viruses	11/1218	48/9376	1.76409414340449	CLDN7/CLDN4/CLDN19/CLDN10/CLDN6/LDLR/EGFR/CLDN3/EPCAM/HSPG2/CLDN5	2.05064579956485
Cellular Processes	Cell motility	hsa04814	Motor proteins	34/1218	194/9376	1.34911042269734	TUBA1C/TNNI2/TPM1/TUBA1B/ACTB/TUBB/TPM3/TPM4/TPM2/MYH9/TUBB4B/ACTG1/KIF21A/CENPE/MYL4/TUBB6/KIF2C/DYNLL2/KIF23/KIF14/KIFC1/MYO1B/DYNLL1/KIF4A/KIF11/MYL12B/KIF20B/CAPZB/KIF9/DNAH14/KIF22/KIF20A/CAPZA1/MYO19	1.8985081571954
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	12/1218	54/9376	1.7106367451195	UBE2T/RPA3/FANCE/RAD51/FANCI/FANCD2/BRCA1/BRCA2/RAD51C/FANCB/BLM/RMI1	2.02351963281305
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	28/1218	155/9376	1.39058212829069	HLA-G/TUBA1C/TUBA1B/CALR/ACTB/TUBB/ITGA5/ITGB1/CTSL/SEC61G/RAC1/TUBB4B/ACTG1/ATP6V1C2/HLA-DRB5/ATP6V1F/TUBB6/CLEC7A/ATP6V1B1/NCF1/SEC61B/NCF4/CD14/CANX/CORO1A/CYBA/ITGAV/ATP6V0E2	1.89455246935604
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1218	37/9376	1.8724537345227	NIT2/ASNS/RIMKLA/PPAT/RIMKLB/ASRGL1/ALDH4A1/ASL/ASS1	2.05452065685814
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1218	61/9376	1.64052868179493	MT1G/MT1E/MT1H/FTH1/MT2A/MT1X/MT1F/HMOX1/SLC6A19/ATP2B3/MT1A/MT1M/ATP1A4	1.93923080436575
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/1218	106/9376	1.45242742510147	CCNE1/GSTP1/HSP90AB1/CTNNB1/HSP90AA1/GRB2/FOLR1/PIK3CB/TCF7L2/SPINT1/IL1R2/ETV5/EGFR/SLC19A1/TP53/FOLR2/E2F3/FOXO1/HRAS/CCNE2	1.81000352387845
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/1218	51/9376	1.66032389967481	ACTB/GNAS/PDIA4/SEC61G/ACTG1/ATP6V1C2/ATP6V1F/TJP2/ATP6V1B1/SEC61B/ATP6V0E2	1.82698556504927
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/1218	82/9376	1.50202250790981	HLA-G/HSPA8/CALR/HSP90AB1/HSP90AA1/CTSL/HSPA5/TNF/HLA-DRB5/PSME2/HSPA4/CANX/PSME3/HSPA2/KLRC1/NFYB	1.76419348087105
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/1218	52/9376	1.62839459391184	CGA/CYP11A1/GNAS/HSD3B1/CYP19A1/LDLR/CYP2J2/ACOT4/HSD17B1/INSR/ADCY1	1.7557004133912
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/1218	149/9376	1.34325167234216	NDUFB2/NDUFS5/NDUFA4/NDUFA6/MT-ND6/GNG5/GNG4/NDUFB11/NDUFC1/NDUFB1/NDUFB3/MAPK13/NDUFB4/NDUFS7/NDUFA1/ADCY1/NDUFA3/NDUFV2/NDUFA12/NDUFA2/NDUFA11/NDUFS6/MAPK9/MGLL/NDUFV3/GNG2	1.63189783998643
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/1218	41/9376	1.68977532139853	RPA3/SSBP1/RAD51/BRCA1/BRCA2/RAD51C/BLM/XRCC2/BRCC3	1.71025099321479
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1218	36/9376	1.7106367451195	PYGL/HK2/UGP2/PGM1/HK1/GYS1/GBE1/PGM2	1.65060404119265
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1218	19/9376	2.0257540402731	GCSH/GLDC/DHTKD1/BCKDHB/PDHA1	1.72929527104741
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1218	87/9376	1.41569937527131	CTNNB1/BIRC5/GRB2/PIK3CB/RAC1/RAC3/TCF7L2/CYCS/EGFR/PMAIP1/AREG/TP53/GADD45A/MAPK9/RALB/HRAS	1.50512284836313
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/1218	68/9376	1.47165072925722	GRB2/PIK3CB/TCF7L2/CCNA2/CSF1R/CEBPA/JUP/CD14/BCL2A1/PIM2/ZBTB16/PPARD/HRAS	1.50821831795672
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1218	31/9376	1.73822766036337	GCSH/GLDC/PGP/ACAT2/SHMT1/PCCA/MDH2	1.59073903930404
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1218	37/9376	1.66440331957573	PPARG/CTNNB1/TPM3/CDH1/TCF7L2/TP53/GADD45A/HRAS	1.56458765724723
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	11/1218	56/9376	1.5120806943467	MAN1A2/B4GALT1/MGAT4A/MAN2A1/TUSC3/MGAT5/MGAT5B/SRD5A3/STT3B/RPN2/TMEM258	1.48505279071817
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/1218	142/9376	1.30104766530216	UBE2C/UBA52/RPS27A/UBE2S/CDC20/ANAPC11/CBLB/RBX1/UBE2F/SKP2/UBE2L3/ANAPC15/UBC/SKP1/UBE2N/UBE2Q2/HERC3/UBE2A/BRCA1/FBXW7/UBE2K/HERC4/UBA1/DDB1	1.39669613850457
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/1218	89/9376	1.38388590616409	ITGA5/SDC4/ITGB1/HMMR/COL4A1/ITGA6/LAMA4/COL4A2/COL6A3/HSPG2/ITGB4/DAG1/LAMC2/RELN/LAMA1/ITGAV	1.40597267507397
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1218	38/9376	1.62060323221848	HK2/UGP2/GNPNAT1/PGM1/HK1/GALE/PGM2/NAGK	1.48114074265387
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/1218	103/9376	1.34525802286097	PRDX1/GNAS/COL4A1/PIK3CB/IL1R2/IL1B/TNF/LAMA4/ARG2/COL4A2/NOS2/ACTN1/CD14/LAMC2/ADCY1/SERPINB9/LAMA1/CXCL2	1.36134967972807
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	29/1218	178/9376	1.25414660246121	NOTUM/CTNNB1/WNT7A/RAC1/RAC3/TCF7L2/SFRP1/CACYBP/RBX1/APCDD1/GPC4/PPP3CA/FRAT2/RUVBL1/SKP1/WNT10B/WNT4/TP53/WNT5A/SFRP4/LGR4/RNF43/WNT6/TLE3/TLE1/PPARD/MAPK9/CSNK1A1/FZD3	1.32271122347562
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	55/1218	362/9376	1.16956517794773	CCNE1/PGF/EFNA1/RPS6/HSP90AB1/ITGA5/YWHAB/YWHAE/HSP90AA1/ITGB1/GRB2/ERBB3/YWHAZ/COL4A1/PIK3CB/IL2RB/RAC1/FLT4/CSF1R/ITGA6/YWHAG/LAMA4/EGFR/GNG5/COL4A2/GNG4/NR4A1/COL6A3/SGK1/ANGPT4/CDC37/AREG/IFNAR2/ITGB4/INSR/GYS1/EIF4E/TP53/LAMC2/RELN/BRCA1/EIF4E2/CSF3R/KDR/LAMA1/MCL1/ITGAV/YWHAQ/EFNA3/EIF4B/EFNA4/LPAR2/HRAS/CCNE2/GNG2	1.27130457607748
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	14/1218	77/9376	1.3996118823705	RALBP1/CDC42/PIK3CB/RAC1/RAC3/EGFR/RAD51/TP53/E2F3/GADD45A/STAT1/BRCA2/MAPK9/RALB	1.36045150050085
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	26/1218	158/9376	1.26673733657583	RPS6/GRB2/WNT7A/PIK3CB/ATP6V1C2/TNF/SLC7A5/SKP2/ATP6V1F/ATP6V1B1/SGK1/LAMTOR2/WNT10B/WNT4/INSR/EIF4E/RPS6KA1/SLC38A9/WNT5A/WNT6/EIF4E2/GRB10/CAB39L/EIF4B/HRAS/FZD3	1.30650607599395
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1218	27/9376	1.7106367451195	SCD/ACOT4/TECR/ELOVL6/ELOVL1/ACOX1	1.42877681417984
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/1218	78/9376	1.38166814028883	CFL1/CALM1/ITGA5/CALM3/ITGB1/IL1B/TNF/NOS2/CD14/MAPK13/IL1A/NLRP3/MAPK9/PYCARD	1.30784377938925
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	18/1218	105/9376	1.31963406052076	CALM1/CALM3/PIK3CB/CBLB/IL1B/TNF/PAK1/CLEC7A/PPP3CA/MAPK13/IL17D/STAT1/EGR3/NLRP3/MAPK9/CLEC4E/HRAS/PYCARD	1.27262908006759
NA	NA	hsa04382	Cornified envelope formation	34/1218	217/9376	1.20611715208887	KRT19/KRT7/DSP/KRT8/CLDN7/CLDN4/KRT18/PRSS8/S100A11/S100A9/KRT23/PKP3/CLDN19/COL4A1/DSG2/PADI1/CLDN10/CLDN6/ITGA6/S100A8/KRT10/JUP/COL4A2/CLDN3/TCHH/PCSK6/ITGB4/S100A12/CLDN5/LAMC2/KRT15/ELOVL1/KRT14/ST14	1.18696360437986
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	27/1218	168/9376	1.23715693173821	HMGB1/PPIA/FTH1/HSP90AB1/PYGL/HSP90AA1/SLC25A5/TNFAIP3/VDAC1/IL1B/TNFSF10/TNF/CHMP4C/SLC25A4/IFNAR2/CHMP2B/CHMP2A/IL1A/PGAM5/STAT1/NLRP3/VDAC2/MAPK9/PARP1/PYCARD/DNM1L/PPID	1.19846468249821
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1218	86/9376	1.34265093366938	DSP/DSC2/ACTB/ITGA5/CTNNB1/ITGB1/DSG2/TCF7L2/ACTG1/ITGA6/JUP/ITGB4/DAG1/LAMA1/ITGAV	1.23341924385134
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1218	34/9376	1.58485463150778	POLR2F/POLR2H/POLR2L/POLR2J/POLR2I/POLR1D/POLR3G	1.32003331592066
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1218	28/9376	1.64954257565095	AKR1B1/GCH1/GGH/DHFR/PCBD2/TH	1.32997880135985
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1218	22/9376	1.74951485296313	ALDH7A1/CNDP2/ALDH1B1/ALDH3B2/MAOB	1.35991051892889
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1218	47/9376	1.47405932292213	PKM/PIK3CB/HK2/PRKCZ/TNF/IRS2/HK1/INSR/MAPK9	1.25887180338035
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	50/1218	333/9376	1.15583563859426	HLA-G/CCNE1/ISG15/PKM/ITGA5/GNAS/CTNNB1/ITGB1/GRB2/CDC42/COL4A1/WNT7A/PIK3CB/TCF7L2/CCNA2/ATP6V1C2/ITGA6/PRKCZ/HEY1/TNF/MX1/LAMA4/EGFR/COL4A2/ATP6V1F/PXN/BCAP31/COL6A3/ATP6V1B1/PARD6B/WNT10B/IFNAR2/ITGB4/WNT4/CRB3/TP53/WNT5A/LAMC2/FOXO1/RELN/STAT1/WNT6/TBPL1/LAMA1/ITGAV/HRAS/CCNE2/ATP6V0E2/CSNK1A1/FZD3	1.11879384435372
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/1218	205/9376	1.20161800632785	HLA-G/CCNE1/ISG15/CALR/TNFAIP3/PIK3CB/RAC1/CYCS/CCNA2/TNF/SKP2/HLA-DRB5/PSMD14/IFNAR2/PSMD11/IRF7/MAPK13/OAS1/TP53/OAS3/E2F3/GADD45A/PSMC4/STAT1/PSMD4/PSMD2/MAPK9/PSMD12/PSMD1/BLNK/ADRM1/CCNE2	1.12775648111644
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	32/1218	205/9376	1.20161800632785	HLA-G/CCNE1/PKM/RANBP1/YWHAB/YWHAE/GRB2/CDC42/CDC20/YWHAZ/PIK3CB/RAC1/CDK1/CCNA2/YWHAG/SKP2/DDX3X/PXN/PMAIP1/ACTN1/CHEK1/IRF7/GTF2A2/TP53/HNRNPK/TBPL1/EGR3/REL/YWHAQ/DDB1/HRAS/CCNE2	1.12775648111644
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	29/1218	184/9376	1.21325051759834	EFNA1/CFL1/ITGB1/CDC42/PIK3CB/RAC1/RAC3/PRKCZ/PAK1/PPP3CA/PARD6B/MYL12B/WNT4/SSH2/PAK3/SEMA6A/SEMA7A/WNT5A/PAK2/BMP7/RGMA/CXCL12/GDF7/SEMA4D/EFNA3/EFNA4/RASA1/HRAS/FZD3	1.12878551948105
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	27/1218	170/9376	1.222602144306	MGST3/MGST1/GSTP1/ACTB/CTNNB1/GRB2/WNT7A/PIK3CB/TCF7L2/ACTG1/EGFR/HMOX1/SMARCA2/FRAT2/WNT10B/WNT4/SMARCC1/TP53/WNT5A/E2F3/GADD45A/GSTO2/WNT6/GSTA3/HRAS/CSNK1A1/FZD3	1.13171155672597
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/1218	101/9376	1.29568030694695	CDC42/EGR1/COL4A1/PIK3CB/RAC1/PRKCZ/IL1B/TNF/COL4A2/PLCD4/DIAPH1/MAPK13/FOXO1/IL1A/STAT1/MAPK9/HRAS	1.15436608814717
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	35/1218	227/9376	1.18689553901463	HLA-G/CALM1/CALR/CCL4/GNAS/CTNNB1/CCL3L1/CALM3/GRB2/CCL3/PIK3CB/RAC1/RAC3/CYCS/IL1B/CCR1/TNF/EGFR/CCL3L3/GNG5/GNG4/CCL4L2/PXN/PTK2B/PPP3CA/IL10RA/CCL4L1/MAPK13/TP53/E2F3/ADCY1/CXCL12/ITGAV/HRAS/GNG2	1.10139343134067
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1218	35/9376	1.53957307060755	TPI1/ALDOA/AKR1B1/PFKP/HK2/PFKFB4/HK1	1.23567720301456
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/1218	95/9376	1.29648258577478	CCL3L1/CTSL/CCL3/ATP6V1C2/IL1B/TNF/CCL3L3/HLA-DRB5/ATP6V1F/IL15/ATP6V1B1/IL1A/CCL20/CXCL12/CXCL2/ATP6V0E2	1.12222783862906
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1218	29/9376	1.59266179718023	PAK1/TEAD1/RASSF6/WWTR1/RASSF2/RASSF4	1.2350576870808
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	33/1218	214/9376	1.18705400303853	HLA-G/CCNB1/CFL1/CALM1/CALR/WEE1/CALM3/CCNB2/AP1M2/PIK3CB/RAC1/RAC3/CYCS/CDK1/RBX1/TNF/PAK1/GNG5/GNG4/PXN/PTK2B/PPP3CA/CHEK1/SKP1/MAPK13/PAK3/PAK2/CDC25C/AP1B1/MAPK9/DDB1/HRAS/GNG2	1.06953790679638
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/1218	109/9376	1.27120712252	SLC2A1/PYGL/PPP1CB/PIK3CB/PTPRF/SLC27A6/PRKCZ/TNF/IRS2/SLC27A2/INSR/GYS1/PPP1R3B/RPS6KA1/PPP1CA/FOXO1/PPP1CC/MAPK9	1.10042941363064
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1218	75/9376	1.33429666119321	MGST3/MGST1/GSTP1/TOP2A/BIRC5/PIK3CB/CYCS/PMAIP1/TP53/BRCA1/GSTO2/GSTA3/MAP3K5	1.12309186228593
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1218	42/9376	1.46626006724529	ACAT2/AADAT/ALDH7A1/KMO/DHTKD1/KYNU/ALDH1B1/MAOB	1.17013616126982
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/1218	76/9376	1.31674012617751	PPARG/PLIN2/DBI/SCD/FABP7/ACSL4/FABP5/HMGCS1/SLC27A6/UBC/SLC27A2/PPARD/ACOX1	1.07123767716346
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	14/1218	83/9376	1.2984351197895	PRDX1/PRDX5/ACSL4/IDH2/SOD1/IDH1/NOS2/FAR2/MPV17L2/SLC27A2/SOD2/ECH1/PECR/ACOX1	1.05518458722909
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	36/1218	238/9376	1.16438299457714	PGF/EFNA1/RALBP1/CALM1/CALM3/GRB2/CDC42/PIK3CB/RAC1/PLA2G10/FLT4/RAC3/CSF1R/TIAM1/EGFR/PAK1/GNG5/GNG4/ANGPT4/RASGRF2/PLA2G2A/INSR/PAK3/PAK2/ARF6/FOXO4/KDR/REL/MAPK9/RASGRP2/EFNA3/RALB/EFNA4/RASA1/HRAS/GNG2	0.992515325100734
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/1218	56/9376	1.37461881304246	HSPA8/BNIP3/HSPD1/CYCS/IL1B/TNF/CD14/CXCL2/RAB1B/PYCARD	1.08640829444659
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	25/1218	160/9376	1.20279146141215	HLA-G/CLDN7/CLDN4/SDC4/ITGB1/CDH1/CLDN19/CDH5/PTPRF/CLDN10/CLDN6/ITGA6/HLA-DRB5/CLDN3/F11R/CD274/PDCD1LG2/PTPRS/ICAM3/CLDN5/SELL/ESAM/ITGAV/CNTNAP2/CDH3	0.99966814919735
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1218	70/9376	1.31963406052076	SLC2A1/GRB2/CDC42/PIK3CB/RAC1/EGLN3/RBX1/PAK1/RAPGEF1/PAK3/PAK2/HRAS	1.03714142197753
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1218	37/9376	1.45635290462877	HBA2/HBA1/HBB/IL1B/TNF/LAMA4/THOP1	1.07465465763631
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	21/1218	133/9376	1.21545242416386	CCNB1/BNIP3/GRB2/CCNB2/PIK3CB/PLK2/TNFSF10/SKP2/EGFR/IRS2/SGK1/PLK1/INSR/MAPK13/HOMER1/SOD2/FOXO1/GADD45A/FOXO4/MAPK9/HRAS	0.96691469528395
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/1218	105/9376	1.2463210571585	TPM1/ACTB/ITGA5/GNAS/TPM3/ITGB1/TPM4/TPM2/ACTG1/ITGA6/TNF/ITGB4/DAG1/ADCY1/ADRB1/LAMA1/ITGAV	0.980731965367416
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/1218	44/9376	1.3996118823705	MAN1A2/B4GALT1/MGAT4A/MAN2A1/TUSC3/STT3B/RPN2/TMEM258	1.02658472622738
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/1218	71/9376	1.30104766530216	CDC42/RAC1/ATP6V1C2/EGFR/PAK1/ATP6V1F/F11R/ATP6V1B1/MAPK13/CXCL2/MAPK9/ATP6V0E2	0.983838199663172
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/1218	78/9376	1.28297755883963	ITGB1/IL1B/TNF/HLA-DRB5/NOS2/NCF1/MARCKSL1/NCF4/MAPK13/CYBA/IL1A/STAT1/PTPN6	0.969665531304484
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1218	46/9376	1.33875919183265	FTH1/HMOX1/ALAS2/CP/CPOX/ALAS1/HMBS/MMAB	0.889911079736558
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1218	26/9376	1.48035872173803	SLC5A6/SLC19A1/PLB1/SLC19A2/AMN	0.947684943770562
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1218	33/9376	1.3996118823705	IDH2/IDH1/AADAT/DHTKD1/BCKDHB/PDHA1	0.888524936414956
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1218	20/9376	1.53957307060755	UGP2/CMAS/NANS/CYB5R4	0.933335080460916
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1218	47/9376	1.31027495370856	PKM/LDHB/LDHA/ACAT2/ALDH7A1/MDH2/ALDH1B1/PDHA1	0.823939898726573
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	43/1218	300/9376	1.10336070060208	PGF/EFNA1/STMN1/HSPA8/GRB2/ERBB3/CDC42/RAC1/FLT4/RAC3/IL1RAP/CSF1R/IL1B/TNF/EGFR/PAK1/NR4A1/DUSP5/PPP3CA/ANGPT4/RASGRF2/AREG/DUSP4/INSR/CD14/MAPK13/RPS6KA1/TP53/PAK2/GADD45A/DUSP9/IL1A/MAPT/KDR/MAP3K4/MAP3K5/MAPK9/RASGRP2/EFNA3/EFNA4/RASA1/HRAS/TAOK3	0.703050076800554
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	36/1218	250/9376	1.10849261083744	HLA-G/ARPC1B/HSPA8/ARPC3/ARPC2/CDC42/RAB11A/FOLR1/ARPC5/IL2RB/CBLB/LDLR/ACTR3/ARPC4/PRKCZ/CLTA/CHMP4C/EGFR/ACTR2/ARF3/PARD6B/SH3KBP1/DNM2/SNX3/CHMP2B/CHMP2A/FOLR2/SNX2/CAPZB/PSD4/ARF6/RAB11FIP4/ARPC5L/ARPC1A/HRAS/CAPZA1	0.671811392753341
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1218	83/9376	1.20568975409025	CCL4/POLR2F/POLR2H/IL1B/POLR2L/CCL4L2/CCL4L1/IRF7/POLR1D/G3BP1/POLR3G/NLRP3/PYCARD	0.727262456308974
Genetic Information Processing	Transcription	hsa03040	Spliceosome	35/1218	243/9376	1.10874603850338	HSPA8/RBM8A/SNRPD2/SNRPG/HNRNPA1/LSM4/SNRPF/SNRPD1/SNRPB/LSM7/LSM3/HNRNPC/LSM5/SNRPE/SRSF3/HNRNPM/LSM2/HNRNPA3/ALYREF/TXNL4A/DDX5/THOC7/SRSF2/SNRPA1/HNRNPU/THOC3/TRA2A/HNRNPK/SNRPD3/PPIH/SRSF6/SNRPA/EIF4A3/MAGOH/ZMAT2	0.663631947384647
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/1218	48/9376	1.28297755883963	HMGCS1/ACAT2/HSD17B10/ALDH7A1/PCCA/ALDH1B1/BCKDHB/MCCC2	0.759444038950593
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1218	148/9376	1.14427728220832	CTNNB1/GRB2/WNT7A/PIK3CB/FLT4/TCF7L2/HEY1/EGFR/FRAT2/WNT10B/WNT4/PGR/TP53/WNT5A/E2F3/GADD45A/BRCA1/WNT6/BRCA2/HRAS/CSNK1A1/FZD3	0.683584882039532
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1218	62/9376	1.24159118597383	HSPA8/PIK3CB/SOD1/IRS2/INSR/CLPB/SOD2/FOXO1/ADCY1/HRAS	0.737439244045818
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	24/1218	163/9376	1.13342802744114	CCNE1/YWHAB/BIRC5/GRB2/YWHAZ/PIK3CB/CYCS/CCNA2/TNF/DDX3X/PTK2B/HSPG2/PCNA/IRF7/MAPK13/TP53/E2F3/STAT1/EGR3/MAPK9/YWHAQ/DDB1/HRAS/CCNE2	0.663984228965274
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1218	28/9376	1.37461881304246	B4GALT1/ST3GAL6/B3GNT5/ST8SIA1/GCNT2	0.767055307248709
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1218	28/9376	1.37461881304246	CA2/ATP6V1C2/ATP6V1F/ATP6V1B1/ATP6V0E2	0.767055307248709
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/1218	63/9376	1.22188338937107	EZH2/ACAT2/AADAT/ALDH7A1/DHTKD1/SMYD2/ALDH1B1/SUV39H1/HYKK/SUV39H2	0.682759413112759
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1218	63/9376	1.22188338937107	CTNNB1/WNT7A/TCF7L2/WNT10B/WNT4/TP53/WNT5A/GADD45A/WNT6/FZD3	0.682759413112759
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/1218	99/9376	1.16634323530875	CALM1/GNAS/PPP1CB/CALM3/PIK3CB/IL1RAP/IL1B/PRKCH/CYP2J2/MAPK13/PPP1CA/ADCY1/PPP1CC/MAPK9/TRPV4	0.642889592133942
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1218	187/9376	1.11145649482363	TXN/HSP90AB1/YWHAE/HSP90AA1/TNFAIP3/VDAC1/IL1B/TNF/TXN2/SUGT1/IFNAR2/IRF7/MAPK13/OAS1/OAS3/CYBA/STAT1/TRPM2/NLRP3/VDAC2/CXCL2/MAPK9/GBP2/RIPK2/BRCC3/PYCARD/DNM1L	0.59485277270678
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/1218	78/9376	1.18428697739043	ENO1/LSM4/HSPD1/PFKP/LSM7/LSM3/LSM5/EXOSC5/LSM2/PABPC1/EXOSC8/PNPT1	0.631487283219718
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/1218	93/9376	1.15881844024224	CGA/CALM1/GNAS/CALM3/GRB2/CDC42/EGR1/EGFR/PTK2B/MAPK13/ADCY1/MAP3K4/MAPK9/HRAS	0.594724263828693
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	16/1218	108/9376	1.14042449674634	RAN/RBM8A/KPNA2/ALYREF/THOC7/RANGAP1/UPF3B/KPNB1/THOC3/NUP155/NUP210/IPO7/NUP50/EIF4A3/MAGOH/NUP37	0.567125497391375
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/1218	109/9376	1.12996188668444	CCL4/CCL3L1/CCL3/PIK3CB/RAC1/IL1B/TNF/CCL3L3/CCL4L2/CCL4L1/IFNAR2/IRF7/CD14/MAPK13/STAT1/MAPK9	0.527323476720077
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1218	44/9376	1.22466039707419	CDK7/TAF10/TAF5L/GTF2A2/TAF4B/TAF9/TBPL1	0.577142328342252
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/1218	44/9376	1.22466039707419	HLA-G/HSPD1/IL1B/TNF/HLA-DRB5/GZMB/IL1A	0.577142328342252
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1218	16/9376	1.44334975369458	MIF/ALDH3B2/MAOB	0.68578182396318
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/1218	30/9376	1.28297755883963	IDH2/IDH1/MDH2/ACLY/PDHA1	0.59981478502071
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1218	23/9376	1.33875919183265	ARG2/NOS2/ASL/ASS1	0.628487972334352
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1218	59/9376	1.17425064707356	CGA/GNAS/PIK3CB/IRS2/INSR/ADCY1/NPR1/ADRB1/MGLL	0.518775896340321
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/1218	59/9376	1.17425064707356	CTNNB1/GRB2/CDH1/PIK3CB/TCF7L2/EGFR/TP53/GADD45A/HRAS	0.518775896340321
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/1218	45/9376	1.19744572158365	HLA-G/IL1B/TNF/HLA-DRB5/GZMB/IL1A/KLRC1	0.512988136426082
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1218	60/9376	1.15467980295566	CDC42/PIK3CB/RAC1/RAC3/PXN/PPP3CA/MAPK13/KDR/HRAS	0.464421083428301
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1218	31/9376	1.24159118597383	ALDH7A1/CNDP2/ALDH1B1/ALDH3B2/ACOX1	0.52058267620476
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	16/1218	112/9376	1.09969505043397	HSPA8/ITGB1/CYCS/LDLR/ITGA6/TNF/LAMA4/HLA-DRB5/NOS2/IL10RA/MAPK13/LAMC2/PPIF/STAT1/LAMA1/MAPK9	0.410110385544897
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/1218	105/9376	1.09969505043397	CCL4/TNFAIP3/IL1B/TNF/CCL4L2/CCL21/CCL4L1/PPP1R13L/CD14/BCL2A1/GADD45A/CXCL12/CXCL2/BLNK/PARP1	0.396937735967067
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/1218	120/9376	1.09053092501368	CALM1/YWHAE/CALM3/GRB2/CDC42/ARHGDIB/PIK3CB/RAC1/SH2B2/RAPGEF1/MAPK13/RPS6KA1/TP53/MAP3K5/MAPK9/RIPK2/HRAS	0.385650003618729
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	21/1218	150/9376	1.07770114942529	CCNE1/CTNNB1/GRB2/CDH1/WNT7A/PIK3CB/TCF7L2/EGFR/JUP/FRAT2/WNT10B/WNT4/TP53/WNT5A/E2F3/GADD45A/WNT6/HRAS/CCNE2/CSNK1A1/FZD3	0.370666877518506
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1218	32/9376	1.20279146141215	LDHB/LDHA/PCCA/BCKDHB/ACOX1	0.443992537927592
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/1218	136/9376	1.07543707138028	CCNE1/HSPA8/TNFAIP3/PIK3CB/IL2RB/CBLB/CYCS/IL1B/MX1/IFNAR2/EIF3H/IRF7/OAS1/TP53/OAS3/IL1A/STAT1/MAPK9/CCNE2	0.342401548662869
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/1218	69/9376	1.11563265986055	GRB2/PIK3CB/RAC1/RAC3/TNF/VAV3/MAPK13/MAPK9/VAV2/HRAS	0.372492588471972
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/1218	99/9376	1.0885870196215	TPM1/ACTB/ITGA5/TPM3/ITGB1/TPM4/TPM2/ACTG1/ITGA6/TNF/ITGB4/DAG1/LAMA1/ITGAV	0.342374445267463
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	17/1218	122/9376	1.07265336886592	DIO2/SLC2A1/ACTB/CTNNB1/PFKP/PIK3CB/ACTG1/PLCD4/WNT4/TP53/MED12L/FOXO1/ATP1A4/STAT1/ITGAV/THRB/HRAS	0.312096110661759
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1218	18/9376	1.28297755883963	PRDX1/CD320/MMAB	0.464316545596122
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/1218	70/9376	1.09969505043397	HLA-G/CD55/ACTB/RAC1/RAC3/CYCS/ACTG1/HLA-DRB5/DAG1/LAMA1	0.32348826092797
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1218	63/9376	1.09969505043397	GPX4/HPGD/PLA2G10/PTGES3/CYP2J2/PLA2G2A/PLB1/HPGDS/PTGES2	0.306772554347034
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1218	26/9376	1.18428697739043	PLA2G10/PLA2G2A/PLB1/ACOX1	0.363574108062385
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1218	86/9376	1.0741207469355	GRB2/ERBB3/PIK3CB/CBLB/EGFR/PAK1/AREG/PAK3/PAK2/MAPK9/NRG4/HRAS	0.266807840445275
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1218	94/9376	1.0645983998882	HSP90AB1/S100A9/HSP90AA1/TNFAIP3/S100A8/IL1B/TNF/TRAF4/MAPK13/IL17D/CCL20/CXCL2/MAPK9	0.243210509314255
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/1218	79/9376	1.07185466941032	ATP6V1C2/CLTA/ATP6V1F/ATP6V1B1/DNM2/SLC1A6/SLC6A11/SLC6A4/SLC1A2/UNC13B/ATP6V0E2	0.247807563504905
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1218	34/9376	1.13203902250555	RBX1/RORB/SKP1/BHLHE40/BHLHE41	0.298015779168216
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1218	57/9376	1.08040215481232	SCD/ACSL4/ACAT2/FASN/TECR/ELOVL6/ELOVL1/ACOX1	0.23525447429722
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/1218	50/9376	1.07770114942529	HBA2/HBA1/HBB/GYPB/GYPA/IL1B/TNF	0.212854174402704
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/1218	142/9376	1.02999606836421	PPARG/GRB2/PIK3CB/RAC1/CSF1R/IL1B/TNF/PPP3CA/NCF1/FHL2/IFNAR2/NCF4/MAPK13/FOSL2/CYBA/IL1A/STAT1/MAPK9/BLNK	0.13916531394641
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/1218	196/9376	1.0211454039744	HLA-G/CALM1/UBA52/RPS27A/CTNNB1/CALM3/PIK3CB/RAC1/TCF7L2/CYCS/CCR1/GNG5/GNG4/UBC/PPP3CA/IFNAR2/IRF7/MAPK13/TP53/E2F3/STAT1/CXCL2/MAPK9/PREX1/HRAS/GNG2	0.115595283256484
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/1218	173/9376	1.02341562497034	ACTB/SLC25A5/RAB11A/VDAC1/PIK3CB/CYCS/ACTG1/IL1B/TNFSF10/TNF/KPNA2/MX1/FDPS/HLA-DRB5/SLC25A4/IFNAR2/IRF7/OAS1/OAS3/IL1A/STAT1/NLRP3/PYCARD	0.120110652461195
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/1218	89/9376	1.03791442962307	TUBA1C/TUBA1B/TUBB/GNAS/GRB2/TUBB4B/CDK1/EGFR/TUBB6/ADCY1/ADRB1/HRAS	0.138860664549287
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	22/1218	166/9376	1.02019902269175	CALM1/PPP1CB/CALM3/SLC25A5/VASP/VDAC1/ADRA2C/PPP3CA/IRS2/ATP2B3/SLC25A4/INSR/PPP1CA/ADCY1/ATP1A4/PPIF/NPR1/ADORA3/ADRB1/VDAC2/PPP1CC/NPPB	0.101454664224052
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1218	51/9376	1.05656975433852	PLA2G10/GDPD3/PAFAH1B3/PLA2G2A/PLB1/GDPD1/LPCAT1	0.15651731619248
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1218	28/9376	1.09969505043397	ACOT4/TECR/ELOVL6/ELOVL1	0.204131813137571
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	39/1218	298/9376	1.00743875425662	LEP/CCL4/EBI3/CCL3L1/GDF15/CCL3/IL2RB/CCR7/IL1RAP/CSF1R/CSF2RB/IL1R2/IL1B/TNFSF10/CCR1/TNF/CCL3L3/CSF2RA/CCL4L2/IL15/IL10RA/CCL21/CCL4L1/CXCR6/IFNAR2/INHA/CXCL13/BMP7/INHBA/IL1RN/IL1A/IL17D/IL20RA/CCL8/CSF3R/CCL20/CXCL12/CXCL2/GDF7	0.0504232328222481
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1218	36/9376	1.06914796569969	GALNT6/GALNT3/GALNT2/ST6GALNAC2/GALNT13	0.160610765497308
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/1218	67/9376	1.03404161458716	CALM1/PPP1CB/CALM3/PPP3CA/RPS6KA1/PPP1CA/ADCY1/PPP1CC/HRAS	0.108047187974341
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/1218	98/9376	1.0211454039744	CALM1/CALM3/PIK3CB/IMPA2/INPP4B/PLCD4/CDS1/SYNJ1/DGKZ/PIK3C2G/SYNJ2/IPPK/MTMR4	0.0813053778024522
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1218	75/9376	1.0263820470717	CGA/GNAS/PDIA4/GPX1/GPX3/HSPA5/LRP2/CANX/ADCY1/ATP1A4	0.0886322414077245
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1218	52/9376	1.03625110521662	VDAC1/LIPG/LDLR/NPC2/LRP2/VDAC2/NCEH1	0.101283621837844
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/1218	107/9376	1.00719733591148	SLC2A1/PKM/CALM1/GNAS/PYGL/CALM3/LDHB/PFKP/LDHA/PGAM1/PPP3CA/GYS1/FOXO1/PDHA1	0.0289310803872158
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1218	76/9376	1.01287702013655	EZR/CA2/CALM1/ACTB/GNAS/CALM3/ACTG1/GAST/ADCY1/ATP1A4	0.0435509996991424
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1218	37/9376	1.04025207473483	MIF/ALDH3B2/MAOB/TH/GSTZ1	0.0947886584144836
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	26/1218	201/9376	0.99574377700986	PPARG/MYCN/HPGD/IL2RB/CCNA2/CSF1R/SPINT1/IL1R2/CEBPA/ETV5/JUP/HMGA2/ETV4/LMO2/DDX5/CD14/BCL2A1/TP53/ASPSCR1/WT1/ZBTB16/FOXO1/GADD45A/GZMB/REL/SIX4	-0.0235687634371522
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/1218	100/9376	1.00072249589491	CD55/ITGA5/CSF1R/GYPA/ITGA6/IL1R2/IL1B/TNF/CSF2RA/HLA-DRB5/CD14/IL1A/CSF3R	0.00280654781537659
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1218	139/9376	0.99684587305525	KRT19/KRT18/HSPA8/CALM1/HSP90AB1/GNAS/KRT23/CALM3/HSP90AA1/GRB2/PIK3CB/EGFR/KRT10/PGR/ADCY1/KRT15/KRT14/HRAS	-0.0144756651555333
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/1218	69/9376	1.00406939387449	CALM1/GNAS/PPP1CB/CALM3/PPP3CA/PPP1CA/MAOB/TH/PPP1CC	0.0131089180137289
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1218	30/9376	1.0263820470717	PLA2G10/CYP2J2/PLA2G2A/PLB1	0.0559208368239811
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1218	101/9376	0.990814352371198	CALM1/GNAS/CTNNB1/CALM3/WNT7A/TCF7L2/WNT10B/WNT4/WNT5A/ADCY1/WNT6/HRAS/FZD3	-0.0358617056030763
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1218	14/9376	1.09969505043397	B3GNT7/B4GALT1	0.144235023191309
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1218	38/9376	1.01287702013655	PIK3CB/SFN/SGK1/INSR/ATP1A4	0.0307324844249307
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	17/1218	133/9376	0.983937676704076	HLA-G/GRB2/PIK3CB/RAC1/RAC3/TNFSF10/TNF/PAK1/PTK2B/PPP3CA/IFNAR2/VAV3/GZMB/PTPN6/KLRC1/VAV2/HRAS	-0.0720850391705017
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/1218	180/9376	0.983616128443714	HLA-G/CALR/ITGA5/PPP1CB/PIK3CB/CYCS/IL1B/TNF/SRSF3/HLA-DRB5/ALYREF/SRSF2/IFNAR2/PILRA/SRPK1/IRF7/OAS1/TP53/OAS3/PPP1CA/STAT1/SRSF6/PPP1CC	-0.0857572286281131
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/1218	78/9376	0.986905814492021	TPI1/PIK3CB/IMPA2/INPP4B/PLCD4/SYNJ1/PIK3C2G/SYNJ2/IPPK/MTMR4	-0.0448692129498132
Organismal Systems	Immune system	hsa04611	Platelet activation	16/1218	126/9376	0.977506711496859	ACTB/GNAS/PPP1CB/VASP/ITGB1/PIK3CB/ACTG1/PRKCZ/VAMP8/MYL12B/MAPK13/APBB1IP/PPP1CA/ADCY1/PPP1CC/RASGRP2	-0.0982165764238892
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/1218	71/9376	0.975785748976618	CGA/GRB2/PIK3CB/MAPK13/ELF5/STAT1/TH/MAPK9/HRAS	-0.0791333329528572
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1218	23/9376	1.00406939387449	REN/THOP1/NLN	0.00754980282888471
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1218	32/9376	0.962233169129721	BIRC5/CYCS/PMAIP1/MAPK9	-0.0826868694116163
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/1218	105/9376	0.953069043709438	UBA52/RPS27A/BNIP3/TOMM20/UBC/FIS1/TP53/PGAM5/ATG9B/MAPK9/USP15/HRAS/TOMM40	-0.186856493433281
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1218	24/9376	0.962233169129721	HS3ST1/HS6ST2/HS6ST1	-0.0715782946323273
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1218	49/9376	0.942595757514829	B4GALT1/GALNT6/GALNT3/GALNT2/GALNT13/EOGT	-0.155664103136777
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/1218	41/9376	0.93876406744363	CDH1/EGFR/TP53/E2F3/HRAS	-0.151830329711747
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/1218	130/9376	0.947429581912341	GNAS/GRB2/COL4A1/PIK3CB/PRKCZ/EGFR/GNG5/COL4A2/GNG4/NOS2/MAPK13/RLN2/ADCY1/MAPK9/HRAS/GNG2	-0.233213450399149
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/1218	122/9376	0.946458854881693	GRB2/CDC42/PIK3CB/CBLB/TNF/PAK1/PPP3CA/VAV3/MAPK13/PAK3/PAK2/PTPN6/MAPK9/VAV2/HRAS	-0.229995985219058
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1218	98/9376	0.942595757514829	CYP11A1/CALM1/GNAS/HSD3B1/CALM3/LDLR/NR4A1/ATP2B3/NR4A2/ADCY1/ATP1A4/NPR1	-0.220722840214897
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/1218	90/9376	0.940850209815727	PPARG/PIK3CB/IRS2/INSR/EIF4E/TP53/SOD2/FOXO1/ADCY1/EIF4E2/HRAS	-0.217860028120057
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8/1218	66/9376	0.933074588247002	CYP11A1/HSD3B1/CYP19A1/DHRS9/HSD17B1/STS/SRD5A3/DHRS11	-0.210816991305481
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/1218	155/9376	0.943609301340113	CCNE1/CYP11A1/GNAS/CTNNB1/HSD3B1/WNT7A/TCF7L2/LDLR/EGFR/NR4A1/WNT10B/WNT4/WNT5A/E2F3/ADCY1/WNT6/NCEH1/CCNE2/FZD3	-0.273527971856633
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/1218	91/9376	0.930511196521049	GRB2/PIK3CB/RAC1/RAC3/PPP3CA/VAV3/DAPP1/PTPN6/BLNK/VAV2/HRAS	-0.257372420910254
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/1218	157/9376	0.931588800686099	SLC2A1/PPARG/CALR/RAC1/SLC16A1/ODC1/ARG2/DUSP5/SGK1/STAB1/DUSP4/MAPK13/TMEM30B/ATP11A/PTPN6/PPARD/ITGAV/MFGE8/UQCRFS1	-0.334004681977606
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1218	17/9376	0.905631218004443	MYH9/DAG1	-0.1504719394283
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/1218	76/9376	0.911589318122893	CALM1/CALM3/GRB2/PIK3CB/EGFR/TP53/E2F3/GADD45A/HRAS	-0.299011226122297
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1218	43/9376	0.895100622446252	ACSL4/ACAT2/ALDH7A1/ALDH1B1/ACOX1	-0.266387558794362
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/1218	134/9376	0.919148101855256	CALM1/GNAS/PPP1CB/CALM3/RAMP1/MYH9/PLA2G10/ADM/PRKCH/PLA2G2A/PPP1CA/ADCY1/NPR1/CALCRL/PPP1CC/NPPB	-0.364231136676803
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1218	44/9376	0.874757426481564	GNAS/RAB11A/ARHGDIB/DYNLL2/DYNLL1	-0.321742467428006
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1218	18/9376	0.855318372559752	ACSL4/FASN	-0.237397176439539
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/1218	103/9376	0.896838681907313	CALR/GNAS/CCL3L1/CCL3/PIK3CB/IL1B/TNF/CCL3L3/NOS2/MAPK13/ADCY1/MAPK9	-0.406764269174877
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/1218	144/9376	0.908775770844736	ID3/CTNNB1/DLX5/GRB2/ID1/WNT7A/PIK3CB/WNT10B/WNT4/MAPK13/WNT5A/INHBA/DUSP9/WNT6/HRAS/TBX3/FZD3	-0.426246653434884
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1218	53/9376	0.871456455060879	GNAS/RAB11A/CLTA/ATP2B3/DNM2/ATP1A4	-0.362599997815489
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/1218	80/9376	0.866009852216749	RPS6/GRB2/ERBB3/PIK3CB/EGFR/EIF4E/EIF4E2/KDR/HRAS	-0.46503670625229
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/1218	122/9376	0.88336159788958	LEP/PPARG/SCD/PFKP/PIK3CB/CCNA2/PFKFB4/FASN/IRS2/INSR/GYS1/HMGCR/FOXO1/CAB39L	-0.501042033159466
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1218	38/9376	0.810301616109239	ADA/BLNK/DCLRE1C/UNG	-0.452736934984714
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/1218	115/9376	0.870193474691226	GCM1/GATA3/NACA/GNAS/EGR1/MMP15/EGFR/SGK1/NR4A2/ADCY1/WNK2/PDE4D/OXSR1	-0.541170275918364
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1218	29/9376	0.796330898590114	CALM1/CALM3/GUCA1A	-0.424429397194002
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1218	90/9376	0.855318372559752	SLC2A1/CA2/ABCG2/GNAS/LDLR/HMGCR/ADCY1/ATP1A4/NCEH1/KCNN2	-0.532890198331911
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/1218	73/9376	0.843601682524687	MGST3/MGST1/GSTP1/HPGDS/GSTO2/ALDH3B2/MAOB/GSTA3	-0.518321743831773
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1218	10/9376	0.769786535303777	ETHE1	-0.281430444183434
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/1218	99/9376	0.855318372559752	GRB2/PIK3CB/RAC1/RAC3/LYPLA1/EGFR/SLC44A2/DGKZ/WASF1/MAPK9/HRAS	-0.559170995331975
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/1218	65/9376	0.829000884173298	AKR1B1/LIPG/ALDH7A1/DGKZ/AGPAT5/ALDH1B1/MGLL	-0.534527202487109
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/1218	65/9376	0.829000884173298	CYP11A1/GNAS/HSD3B1/LDLR/NR4A1/ADCY1/NCEH1	-0.534527202487109
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1218	65/9376	0.829000884173298	CGA/KISS1/PIK3CB/KISS1R/KCNN4/HRAS/KCNN2	-0.534527202487109
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1218	39/9376	0.789524651593617	HLA-G/TNF/HLA-DRB5/GZMB	-0.508917392158104
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/1218	109/9376	0.847471415013332	GATA3/HSP90AB1/EBI3/HSP90AA1/IL2RB/IL1RAP/IL1B/HLA-DRB5/PPP3CA/MAPK13/STAT1/MAPK9	-0.618888397101052
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/1218	110/9376	0.839767129422302	ID3/ID1/RBX1/TNF/SKP1/GREM2/BMP7/INHBA/TFDP1/RGMA/NOG/GDF7	-0.653159487600019
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1218	144/9376	0.855318372559752	CTNNB1/SCD/TCF7L2/IL1B/TNF/ALDH7A1/FASN/CD14/MAPK13/TRA2A/ALDH1B1/FOXO1/CXCL2/MAP3K5/MAPK9/ACOX1	-0.676027192347726
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/1218	103/9376	0.822102125081703	RBM8A/PPP1CB/PAPOLA/ALYREF/PABPC1/UPF3B/PPP1CA/PPP1CC/EIF4A3/MAGOH/GSPT1	-0.701449927325368
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/1218	154/9376	0.84976435715352	TPM1/CALM1/GNAS/PPP1CB/TPM3/CALM3/TPM4/TPM2/CREM/MYL4/ATP2B3/MAPK13/PPP1CA/ADCY1/ATP1A4/ADRB1/PPP1CC	-0.726337075349689
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1218	69/9376	0.780942861902382	CALM1/GNAS/CALM3/REN/PPP3CA/NPR1/ADRB1	-0.705658422902758
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1218	12/9376	0.641488779419814	VKORC1	-0.480153506720857
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/1218	181/9376	0.850592856689256	CALM1/CALM3/HSPD1/CYCS/IL1B/TNF/HLA-DRB5/NOS2/CLEC7A/PPP3CA/IL10RA/CD14/MAPK13/CORO1A/IL1A/STAT1/MAPK9/NFYB/RIPK2/CLEC4E	-0.784245823518341
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1218	23/9376	0.669379595916327	B4GALT1/MGAT5B	-0.613388366676582
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1218	23/9376	0.669379595916327	CA2/ATP1A4	-0.613388366676582
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/1218	33/9376	0.699805941185252	VAMP8/VTI1B/SNAP29	-0.66747241207713
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/1218	133/9376	0.810301616109239	CALM1/GNAS/PPP1CB/CALM3/GNG5/GNG4/PPP3CA/MAPK13/PPP1CA/MAOB/TH/PPP1CC/MAPK9/GNG2	-0.85133484001134
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/1218	125/9376	0.800577996715928	PIK3CB/RAC1/RAC3/PRKCZ/TNF/MAPK13/TP53/DEGS2/ORMDL2/ADORA3/MAP3K5/MAPK9/HRAS	-0.867263706937123
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/1218	99/9376	0.777562156872502	GNAS/GRB2/PIK3CB/EGFR/MAPK13/TP53/E2F3/ADCY1/MAPK9/HRAS	-0.859686142198454
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/1218	99/9376	0.777562156872502	KRT19/KRT18/KRT23/KRT10/HLA-DRB5/DEFB1/KRT15/FPR1/KRT14/MASP1	-0.859686142198454
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	12/1218	117/9376	0.789524651593617	ACTB/CDK2AP2/MORF4L2/ACTG1/MBD2/BAZ1A/ACTR6/SMARCA2/RUVBL1/GATAD2A/SMARCC1/CECR2	-0.885175852223504
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/1218	73/9376	0.738151472209101	CDH1/PIK3CB/EGFR/TP53/E2F3/GADD45A/HRAS	-0.867795688184334
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/1218	73/9376	0.738151472209101	GRB2/PIK3CB/EGFR/TP53/E2F3/GADD45A/HRAS	-0.867795688184334
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/1218	119/9376	0.776255329718094	TNFAIP3/PIK3CB/IL1B/TNF/IL15/MAPK13/PGAM5/CCL20/CXCL2/MAP3K5/MAPK9/DNM1L	-0.949092364903998
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1218	36/9376	0.641488779419814	DCXR/AKR1B1/UGP2	-0.832718084966253
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1218	93/9376	0.7449547115843	CALM1/GNAS/CALM3/CST3/ATP2B3/KCNN4/ADCY1/ATP1A4/ADRB1	-0.955063034019507
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/1218	66/9376	0.699805941185252	GATA3/IL1B/TNF/HLA-DRB5/IL1A/STAT1	-0.945620006353879
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1218	15/9376	0.513191023535851	ST8SIA1	-0.729055375596461
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/1218	226/9376	0.817472426871267	CGA/CALM1/GNAS/PPP1CB/CALM3/PIK3CB/RAC1/RAC3/TIAM1/PAK1/HCAR3/ATP2B3/VAV3/HCAR2/PPP1CA/ADCY1/ATP1A4/PDE4D/NPR1/ADRB1/PPP1CC/MAPK9/VAV2/ACOX1	-1.07322204247996
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1218	27/9376	0.570212248373168	HMGCS1/ACAT2	-0.864113457065376
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/1218	104/9376	0.740179360869016	PLA2G10/LYPLA1/PLA2G2A/CDS1/DGKZ/AGPAT5/PLB1/PHOSPHO1/PCYT2/LPCAT1	-1.02948740277759
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1218	48/9376	0.641488779419814	PIK3CB/HK2/HK1/ATP1A4	-0.962158308535084
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1218	38/9376	0.607726212081929	PNP/SIRT7/NT5E	-0.936206354394359
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1218	16/9376	0.48111658456486	ST8SIA1	-0.802618727305055
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/1218	116/9376	0.729969990374271	GNAS/SLC38A1/GNG5/GNG4/PPP3CA/SLC1A6/HOMER1/ADCY1/SHANK2/SLC1A2/GNG2	-1.13071450922569
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1218	79/9376	0.682089335079296	MGST3/MGST1/GSTP1/HPGDS/GSTO2/ALDH3B2/GSTA3	-1.09638897419946
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1218	17/9376	0.452815609002222	CTH	-0.872490825856007
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1218	17/9376	0.452815609002222	CA2	-0.872490825856007
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/1218	89/9376	0.691942953082046	SLC38A1/GNG5/GNG4/SLC6A11/PLCL1/HAP1/ADCY1/GNG2	-1.1282513459754
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/1218	70/9376	0.65981703026038	LEP/SLC2A1/ACSL4/TNF/IRS2/MAPK9	-1.10381806117116
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1218	70/9376	0.65981703026038	MGST3/MGST1/GSTP1/HPGDS/GSTO2/GSTA3	-1.10381806117116
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/1218	90/9376	0.684254698047801	PIK3CB/EGFR/PPP3CA/CD274/MAPK13/STAT1/PTPN6/HRAS	-1.16295053875562
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/1218	217/9376	0.780428745469267	MGST3/MGST1/HSP90AB1/GNAS/BIRC5/HSP90AA1/GRB2/KLF5/PIK3CB/KPNA2/CDC6/EGFR/PTGES3/PGR/KPNB1/RPS6KA1/ADCY1/GSTO2/GSTA3/ADRB1/HRAS/CDC25A	-1.26444153266605
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1218	72/9376	0.641488779419814	ISG15/TNF/DDX3X/IRF7/MAPK13/MAPK9	-1.17991733540429
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1218	31/9376	0.496636474389533	ALDH7A1/ALDH1B1	-1.08465186844416
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	34/1218	323/9376	0.810301616109239	CCNE1/EFNA1/STMN1/TPM1/EZR/SOX4/ITGA5/GRB2/ERBB3/PIK3CB/SLC7A1/DNMT1/EZH2/TRIM71/EGFR/HMOX1/HMGA2/IRS2/KIF23/CDCA5/TP53/HNRNPK/E2F3/BRCA1/CDC25C/MCL1/TP63/EFNA3/EFNA4/HRAS/CCNE2/ST14/CDC25A/FZD3	-1.34055940480716
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/1218	102/9376	0.679223413503332	CA2/GNAS/RAB11A/RAC1/PLA2G10/ATP2B3/PLA2G2A/ADCY1/ATP1A4	-1.25859682994532
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1218	19/9376	0.405150808054619	HPSE	-1.00284264475687
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/1218	149/9376	0.723289362030394	GNAS/GRB2/PIK3CB/EGFR/PTK2B/DNM2/DGKZ/INSR/AGPAT5/ADCY1/ARF6/RALB/LPAR2/HRAS	-1.31554637249877
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1218	43/9376	0.537060373467751	PLA2G10/ACAT2/PLA2G2A	-1.1756157172421
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/1218	32/9376	0.48111658456486	ATG10/ATG9B	-1.13604568409003
Human Diseases	Immune disease	hsa05310	Asthma	2/1218	32/9376	0.48111658456486	TNF/HLA-DRB5	-1.13604568409003
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1218	54/9376	0.570212248373168	HLA-G/CGA/HLA-DRB5/GZMB	-1.22380943475309
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/1218	168/9376	0.733130033622644	LEP/GRB2/PIK3CB/IL2RB/CSF2RB/EGFR/CSF2RA/IL15/IL10RA/IFNAR2/STAT1/IL20RA/CSF3R/MCL1/PTPN6/HRAS	-1.34861851677098
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1218	115/9376	0.669379595916327	GNAS/GNG5/GNG4/APP/CYP2J2/SLC6A4/MAOB/HRAS/KCNN2/GNG2	-1.37837396753819
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1218	45/9376	0.513191023535851	ABCA7/ABCG2/DEFB1	-1.264789267799
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/1218	77/9376	0.599833663873073	GRB2/PIK3CB/TP53/E2F3/GADD45A/HRAS	-1.36233910064029
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/1218	21/9376	0.366565016811322	CHST11	-1.12281247214814
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1218	21/9376	0.366565016811322	ALDH1B1	-1.12281247214814
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/1218	154/9376	0.699805941185252	CALM1/ACTB/GNAS/PPP1CB/CALM3/ACTG1/EGFR/PPP3CA/PPP1CA/ADCY1/NPR1/TRPM2/PPP1CC/HRAS	-1.45133385517354
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/1218	88/9376	0.612330198537095	CD55/TFPI/PROCR/F5/SERPINB2/F13A1/MASP1	-1.41175598124362
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1218	68/9376	0.566019511252777	ALDH1A3/ALDH1A2/DHRS9/RDH13/ALDH1A1	-1.38775853012073
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/1218	140/9376	0.65981703026038	CALM1/RPS6/CALM3/CDH1/EGR1/GNG5/GNG4/NOS2/MYL4/ADCY1/HRAS/GNG2	-1.5669388764104
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/1218	49/9376	0.471297878757414	GNAS/MAOB/TH	-1.43369092538758
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	15/1218	169/9376	0.683242486956015	HMGB1/UBA52/RPS27A/BNIP3/CTSL/PIK3CB/UBC/VAMP8/IRS2/ATG10/ATG9B/SNAP29/MAPK9/HRAS/MTMR4	-1.60556775350334
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1218	50/9376	0.461871921182266	HLA-DRB5/IL15/CXCL12	-1.47414560514062
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/1218	93/9376	0.579409220121122	GATA3/IL2RB/HLA-DRB5/PPP3CA/MAPK13/STAT1/MAPK9	-1.57497795315879
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/1218	83/9376	0.556472194195501	CBX3/EZH2/AURKB/SKP1/TFDP1/L3MBTL2	-1.56819246013185
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1218	86/9376	0.537060373467751	SLC2A1/GNAS/KCNN4/ADCY1/ATP1A4/KCNN2	-1.66641496636686
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/1218	97/9376	0.555516056404787	CALM1/GNAS/CALM3/GNG5/GNG4/ADCY1/GNG2	-1.70023436124194
NA	NA	hsa04081	Hormone signaling	19/1218	219/9376	0.66785133199871	DIO2/LEP/CGA/GNAS/RAMP1/PIK3CB/GAST/GNG5/GNG4/ADRA2C/IRS2/INSR/ADCY1/NPR1/ADRB1/NPPB/ITGAV/THRB/GNG2	-1.9217433961315
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/1218	122/9376	0.567875312929016	GNAS/GRB2/PIK3CB/IRS2/MAPK13/ADCY1/STAT1/MAPK9/HRAS	-1.85627227286151
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/1218	91/9376	0.507551561738754	GNAS/GNG5/GNG4/ADCY1/PDE4D/GNG2	-1.82392904156368
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/1218	103/9376	0.523155897779266	COL4A1/SLC6A19/COL4A2/COL6A3/COL27A1/KCNN4/ATP1A4	-1.88019255992733
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/1218	195/9376	0.631619721274894	HMGB1/ACTB/SLC25A5/VDAC1/PIK3CB/RAC1/ACTG1/CLEC7A/SLC25A4/NCF1/NCF4/MAPK13/CYBA/PPIF/VDAC2/FPR1	-2.00856604205348
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	22/1218	254/9376	0.666744243176499	CALM1/GNAS/CALM3/SLC25A5/ERBB3/VDAC1/FLT4/EGFR/NOS2/PTK2B/PLCD4/PPP3CA/ATP2B3/SLC25A4/CHRM5/MST1/SLN/ADCY1/PPIF/KDR/ADRB1/VDAC2	-2.08049615058909
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/1218	62/9376	0.37247735579215	HEY1/TLE3/TLE1	-1.9154665038831
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/1218	191/9376	0.604544399453228	CALM1/GNAS/PPP1CB/CALM3/GRB2/GNG5/GNG4/SLC29A1/SLC29A2/PPP1CA/MAOB/TH/PPP1CC/HRAS/GNG2	-2.1334981257557
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	21/1218	250/9376	0.646620689655172	CTSV/GM2A/CTSL/AP1M2/NPC2/ATP6V1C2/CLTA/ATP6V1F/VAMP8/ATP6V1B1/CTSH/LAMTOR2/SLC29A1/SLC29A2/CTSE/SLC38A9/CTSW/AP5B1/SNAP29/AP1B1/ATP6V0E2	-2.18820659601134
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/1218	115/9376	0.468565717141429	PIK3CB/GNG5/GNG4/CHRM5/ADCY1/HRAS/GNG2	-2.21557765915802
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/1218	55/9376	0.279922376474101	GM2A/DEGS2	-2.06941140383653
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/1218	56/9376	0.274923762608492	LRP2/CSNK1A1	-2.102747675726
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	13/1218	183/9376	0.546842893931645	RAN/NHP2/FBL/POP7/IMP4/NOP10/UTP6/POP5/NOP56/UTP14A/EIF6/DKC1/RRP7A	-2.39201082837933
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/1218	73/9376	0.316350630946758	PPIA/RAN/MX1	-2.26569146559458
NA	NA	hsa04082	Neuroactive ligand signaling	14/1218	199/9376	0.54155836654537	GNAS/GNG5/GNG4/ADRA2C/P2RY14/SLC1A6/CHRM5/SLC6A11/ADCY1/SLC6A4/ADORA3/ADRB1/SLC1A2/GNG2	-2.52567610509783
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/1218	60/9376	0.256595511767926	GNAS/HRAS	-2.23204782559207
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/1218	143/9376	0.322987357470116	SNRPD1/SNRPB/TNF/HLA-DRB5/ACTN1/SNRPD3	-3.15217856573733
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	21/1218	370/9376	0.43690587138863	LEP/CGA/KISS1/KISS1R/GAL/ADM/GZMA/ADRA2C/P2RY14/VGF/TMEM97/CHRNA5/CHRM5/RLN2/ADORA3/ADRB1/CALCRL/NMB/FPR1/THRB/LPAR2	-4.27005355076956
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1218	449/9376	0.034288932530235	CALM1/CALM3	-8.10279858550803