category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	111/1231	222/9376	3.80828594638505	RPS26/RPL38/RPSA/RPL22/RPS29/RPL36/RPS5/RPL14/RPL23A/UBA52/RPL23/RPL29/RPS13/RPL24/RPL27A/RPS27/RPL37A/RPL26/RPS7/RPL39/RPL15/RPL9/RPL37/RPS3/RPS15/RPL21/RPS16/RPS19/RPS11/RPLP2/RPL18A/RPL18/RPS3A/RPS23/RPS6/RPL6/RPL11/RPL8/RPL32/RPS24/RPS27A/RPS14/RPS4X/RPS2/RPS12/RPS18/RPLP1/RPL13/RPS28/RPS20/RPL13A/RPL31/RPL10A/RPS25/RPL27/RPL30/RPL34/RPL35/RPS15A/RPL5/RPL7A/RPLP0/RPL19/RPL28/RPL7/RPS10/RPL4/RPS21/RPL17/MRPS15/MRPS22/DAP3/MRPS25/MRPL45/MRPL47/MRPS11/MRPS7/MRPL19/MRPL4/MRPL55/RPS9/MRPL42/RPL36A/MRPS12/RPS27L/MRPS5/MRPL44/MRPL9/MRPS9/RPL26L1/MRPS35/MRPL35/RPL22L1/MRPL46/MRPL49/MRPL22/MRPL1/MRPL40/MRPL17/MRPS28/MRPL20/MRPS16/MRPL23/MRPS27/MRPL39/MRPS18C/MRPL11/MRPS34/MRPL37/MRPL38/MRPL48	16.4619576517163
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	86/1231	238/9376	2.75220665032869	RPS26/RPL38/RPSA/RPL22/RPS29/RPL36/RPS5/RPL14/RPL23A/UBA52/RPL23/RPL29/RPS13/RPL24/RPL27A/RPS27/RPL37A/RPL26/RPS7/RPL39/RPL15/RPL9/RPL37/RPS3/RPS15/RPL21/RPS16/RPS19/RPS11/RPLP2/RPL18A/RPL18/RPS3A/RPS23/RPS6/RPL6/RPL11/RPL8/RPL32/RPS24/RPS27A/RPS14/RPS4X/RPS2/RPS12/RPS18/RPLP1/RPL13/RPS28/RPS20/RPL13A/RPL31/RPL10A/RPS25/RPL27/RPL30/RPL34/RPL35/RPS15A/RPL5/RPL7A/RPLP0/RPL19/RPL28/RPL7/RPS10/RPL4/RPS21/RPL17/PIK3CB/ISG15/CCL2/RPS9/MAPK3/RPL36A/RPS27L/RPL26L1/TNF/OAS3/RPL22L1/TBK1/IFNAR2/ADAM17/MAPK9/IRF3/C7	10.6443058843389
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	61/1231	158/9376	2.9405752244239	CCNE1/CCNB1/CDKN1C/PTTG1/WEE1/SKP2/YWHAE/CDC20/CDK1/CCNB2/CCNA2/MAD2L1/AURKB/CDT1/CDK7/ORC6/ANAPC11/RBX1/CCND3/ANAPC10/CDC6/PKMYT1/YWHAZ/MCM5/MCM4/PCNA/CDCA5/PLK1/MCM7/CDC45/TTK/CUL1/HDAC1/HDAC8/BUB3/E2F4/BUB1B/ORC5/PPP2R5A/CDK2/MCM2/EP300/YWHAB/CDC23/ORC4/PPP2R1B/TICRR/BUB1/CCNE2/ANAPC15/CDC25C/CDC25A/ESCO2/SFN/ORC1/TRIP13/ANAPC4/MDM2/ANAPC1/FBXO5/MCM3	9.5633443608399
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	94/1231	368/9376	1.94553738565323	TUBA1C/TUBA1B/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND5/GPX3/COX4I1/PFN1/COX5B/COX5A/HNRNPA1/UQCR10/TUBB4B/CHCHD10/PSMA7/COX7B/SRSF3/PSMA4/MT-ND6/HNRNPA2B1/COX7C/SOD1/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/PSMD6/SDHB/VDAC1/RAC1/CASP3/HNRNPA3/COX8C/NUP62/NUP54/ADRM1/RAB8A/NDUFA6/NDUFS3/TUBB/CHMP2B/PPP3R1/PSMD12/NUP98/NDUFA11/NDUFA9/COX6B1/DCTN5/TNF/APAF1/NOS2/NDUFS5/TOMM40/NUP85/PSMB6/TBK1/ATXN2L/NDUFS4/NXT2/PSMB3/PSMC3/NCBP1/TARDBP/NDUFA3/NUP153/PSMD14/SIGMAR1/NUP50/NXF1/COX6A1/GRIN2D/MAP2K6/NUP107/PPP3CA/PSMB2/ITPR3/NRG4/SDHA/NUP93/NUP155/NDUFV2/TRAF2/PSMB1/NDUFB2/NUP43/COX7A2	7.19378652529117
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	72/1231	275/9376	1.99415700465254	TUBA1C/TUBA1B/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND5/COX4I1/SLC25A5/COX5B/HSPA8/COX5A/UQCR10/TUBB4B/PSMA7/COX7B/PSMA4/MT-ND6/PIK3CB/COX7C/SOD1/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/PSMD6/SDHB/VDAC1/CSNK2A2/RAC1/CASP3/COX8C/ADRM1/MAPK3/NDUFA6/NDUFS3/TUBB/PPP3R1/PSMD12/PPIF/NDUFA11/NDUFA9/COX6B1/TNF/APAF1/NDUFS5/PSMB6/NDUFS4/PSMB3/PSMC3/NDUFA3/PSMD14/COX6A1/GRIN2D/STIP1/PPP3CA/PSMB2/ITPR3/SDHA/MAPK9/NDUFV2/PSMB1/NDUFB2/CREB3L4/COX7A2/C7	6.50497882067566
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	58/1231	205/9376	2.15493253551544	UQCRH/COL3A1/GAPDH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND5/COX4I1/PPP1CB/SLC25A5/COX5B/COX5A/UQCR10/COL1A1/COX7B/MT-ND6/PIK3CB/COX7C/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/SDHB/PRKCZ/VDAC1/GFPT1/RAC1/COX8C/NDUFA6/NDUFS3/PPIF/SLC2A1/NDUFA11/NDUFA9/AKT1/COX6B1/NDUFS5/GSR/COL1A2/NDUFS4/NDUFA3/PPP1CC/COX6A1/PLCB3/SDHA/MAPK9/NDUFV2/CPT2/PDHA1/PARP1/NDUFB2/COX7A2	6.49971509070585
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	70/1231	268/9376	1.98940310632055	TUBA1C/TUBA1B/CALM1/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/UBA52/MT-CO2/MT-CO1/RPS27A/MT-ND2/MT-ND5/COX4I1/SLC25A5/COX5B/COX5A/UQCR10/GNAS/TUBB4B/PSMA7/COX7B/PSMA4/MT-ND6/GNAI1/COX7C/UBB/SOD1/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/PSMD6/SDHB/VDAC1/CASP3/COX8C/ADRM1/NDUFA6/NDUFS3/TUBB/SLC39A8/PSMD12/PPIF/NDUFA11/NDUFA9/COX6B1/APAF1/NDUFS5/CALM3/ADCY5/PSMB6/NDUFS4/PSMB3/PSMC3/NDUFA3/PSMD14/COX6A1/TXN2/PSMB2/ITPR3/SDHA/MAPK9/NDUFV2/PSMB1/NDUFB2/COX7A2	6.38849083260291
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	38/1231	116/9376	2.49508389590745	GCSH/GAPDH/ALDOA/ENO1/TPI1/PKM/IDH2/GLDC/PHGDH/IDH1/PFKP/GPT2/TALDO1/SDHB/IDH3B/GOT1/TKT/MCEE/ACOX1/PGK1/HK1/PSAT1/FH/IDH3G/GLYCTK/SUCLG1/SHMT1/ACAT2/ACOX3/PCCB/GOT2/PGP/HK2/SDHA/ACSS2/PDHA1/RPIA/DLAT	6.29880531363446
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	61/1231	235/9376	1.97706759769777	UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/MT-CO2/MT-CO1/RPS6/MT-ND2/MT-ND5/COX4I1/PPARG/COX5B/COX5A/UQCR10/GNAS/COX7B/MT-ND6/COX7C/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/SDHB/ACTL6A/SMARCB1/COX8C/NDUFA6/NDUFS3/NDUFAF6/NDUFA11/ARID1A/NDUFA9/COX6B1/COX19/NDUFS5/ADCY5/TSC1/NRAS/PRKAB2/RPS6KB2/COX16/MLST8/NDUFS4/SMARCD2/COA7/NDUFA3/SMARCA2/COX6A1/GRB2/ACSL4/SDHA/COA6/NDUFV2/CPT2/RPS6KA1/NDUFB2/CREB3L4/COX7A2	5.89699565941617
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	42/1231	138/9376	2.3180870977996	UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND5/COX4I1/COX5B/COX5A/UQCR10/COX7B/ATP6V1C2/MT-ND6/ATP6V1B1/COX7C/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/SDHB/COX8C/NDUFA6/NDUFS3/NDUFA11/NDUFA9/COX6B1/NDUFS5/ATP6V1A/NDUFS4/NDUFA3/ATP6V1E1/COX6A1/SDHA/NDUFV2/PPA1/NDUFB2/COX7A2	6.06406424200071
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	73/1231	308/9376	1.8052264551046	TUBA1C/TUBA1B/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND5/GPX3/COX4I1/PPARG/SLC25A5/COX5B/COX5A/UQCR10/TUBB4B/PSMA7/COX7B/PSMA4/MT-ND6/CLTA/COX7C/SOD1/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/PSMD6/SDHB/VDAC1/CASP3/COX8C/ADRM1/NDUFA6/NDUFS3/TUBB/PSMD12/PPIF/HDAC1/NDUFA11/NDUFA9/COX6B1/DCTN5/APAF1/CASP8/NDUFS5/POLR2D/EP300/PSMB6/NDUFS4/TBPL1/PSMB3/PSMC3/NDUFA3/PSMD14/COX6A1/POLR2F/PSMB2/PLCB3/SDHA/MAPK9/NDUFV2/TRAF2/POLR2I/PSMB1/NDUFB2/CREB3L4/COX7A2	5.58607494065033
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	58/1231	227/9376	1.94608444837298	MGST3/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND5/COX4I1/SLC25A5/COX5B/COX5A/UQCR10/COX7B/MT-ND6/PIK3CB/COX7C/SOD1/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/SDHB/VDAC1/RAC1/COX8C/GSTA3/MAPK3/NDUFA6/NDUFS3/GSTM4/PPIF/NDUFA11/NDUFA9/ARNT/AKT1/HMOX1/COX6B1/PRKD3/SLC26A2/NDUFS5/NRAS/NDUFS4/NDUFA3/COX6A1/PLD2/GRB2/SDHA/MAPK9/NDUFV2/MET/BRAF/NDUFB2/COX7A2	5.6095127412658
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	17/1231	36/9376	3.59671450491922	RPA3/SSBP1/RPA2/MCM5/MCM4/PCNA/MCM7/RFC3/LIG1/POLD2/POLE3/RNASEH2A/MCM2/RPA1/DNA2/FEN1/MCM3	6.06835719796702
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	85/1231	388/9376	1.66857889403469	TUBA1C/TUBA1B/CALM1/UQCRH/GAPDH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/MT-CO2/MT-CO1/MT-ND2/MT-ND5/CTNNB1/COX4I1/SLC25A5/COX5B/COX5A/UQCR10/TUBB4B/PSMA7/COX7B/PSMA4/MT-ND6/WNT7A/PIK3CB/COX7C/NCSTN/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/NAE1/PSMD6/SDHB/VDAC1/CAPN1/CSNK2A2/CASP3/COX8C/ADRM1/MAPK3/NDUFA6/NDUFS3/TUBB/PPP3R1/SLC39A8/PSMD12/PPIF/NDUFA11/NDUFA9/AKT1/COX6B1/TNF/APAF1/NOS2/CASP8/DVL3/NDUFS5/CALM3/NRAS/PSMB6/ADAM17/NDUFS4/PSMB3/PSMC3/NDUFA3/PSMD14/COX6A1/GRIN2D/PPP3CA/PSMB2/ITPR3/PLCB3/SDHA/MAPK9/NDUFV2/TRAF2/PSMB1/FZD6/BRAF/NDUFB2/COX7A2	5.22884916147195
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	43/1231	157/9376	2.08606746107716	LEP/UQCRH/MT-CO3/MT-CYB/MT-CO2/MT-CO1/COX4I1/PPARG/COX5B/COX5A/UQCR10/COX7B/PIK3CB/COX7C/NDUFAB1/NDUFB11/NDUFV3/SDHB/RAC1/CASP3/COX8C/NDUFA6/NDUFS3/ADIPOR2/NDUFA11/CDC42/NDUFA9/AKT1/RXRA/COX6B1/TNF/CASP8/NDUFS5/PRKAB2/NDUFS4/NDUFA3/COX6A1/SDHA/MAPK9/NDUFV2/TRAF2/NDUFB2/COX7A2	5.33499284551708
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	33/1231	108/9376	2.3272858561242	RAN/RBM8A/KPNA2/NUP62/NUP54/TMEM33/THOC6/UPF1/SAP18/TNPO3/NUP98/XPO6/RNPS1/TNPO1/AAAS/SENP2/NUP85/NXT2/NCBP1/NUP153/XPO1/NUP50/NXF1/XPOT/IPO7/NUP107/IPO4/THOC7/NUP93/NUP155/MAGOHB/UPF3B/NUP43	5.39327359324593
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	39/1231	138/9376	2.15250944795677	CCNE1/CCNB1/CALM1/PTTG1/PPP1CB/YWHAE/CDC20/CDK1/CCNB2/AURKA/MAD2L1/ANAPC11/RBX1/ANAPC10/PKMYT1/YWHAZ/PLK1/MAPK3/PPP3R1/CUL1/PPP2R5A/CDK2/CALM3/ADCY5/CPEB4/YWHAB/CDC23/PPP2R1B/BUB1/CCNE2/ANAPC15/PPP1CC/CDC25C/PPP3CA/ANAPC4/ITPR3/ANAPC1/RPS6KA1/FBXO5	5.30229856857701
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	94/1231	480/9376	1.49157866233415	TUBA1C/TUBA1B/CALM1/UQCRH/MT-ND1/MT-CO3/MT-ND3/MT-ND4/MT-ATP6/MT-CYB/UBA52/MT-CO2/MT-CO1/RPS27A/MT-ND2/MT-ND5/GPX3/CTNNB1/COX4I1/SLC25A5/COX5B/COX5A/UQCR10/TUBB4B/PSMA7/COX7B/PSMA4/MT-ND6/WNT7A/COX7C/UBB/SOD1/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/PSMD6/SDHB/VDAC1/CAPN1/CSNK2A2/RAC1/CASP3/COX8C/ADRM1/MAPK3/BAK1/RAB8A/NDUFA6/NDUFS3/TUBB/CHMP2B/PPP3R1/PSMD12/PPIF/NDUFA11/NDUFA9/COX6B1/DCTN5/TNF/APAF1/NOS2/CASP8/DVL3/NDUFS5/CALM3/NRAS/TOMM40/PSMB6/TBK1/ATXN2L/NDUFS4/PSMB3/PSMC3/TARDBP/NDUFA3/PSMD14/SIGMAR1/COX6A1/GRIN2D/MAP2K6/PPP3CA/PSMB2/ITPR3/PLCB3/SDHA/MAPK9/NDUFV2/TRAF2/PSMB1/FZD6/BRAF/NDUFB2/COX7A2	4.29818768365553
Genetic Information Processing	Transcription	hsa03040	Spliceosome	54/1231	243/9376	1.69257153172669	HSPA8/RBM8A/HNRNPA1/SNRPB/SNRPD1/SNRPD2/SNRPF/LSM7/HNRNPC/SRSF3/LSM4/LSM3/SNRNP40/HNRNPK/SF3A3/WBP11/SNRPG/HNRNPA3/HNRNPM/SMNDC1/THOC6/SRSF1/EFTUD2/SF3B3/SNRPE/U2AF2/PPIL1/PRPF3/PHF5A/SNRNP70/DDX23/RBM17/SNRPD3/CTNNBL1/DHX15/SRSF9/PRPF38A/SNRNP200/SF3A2/U2AF1/TCERG1/NCBP1/PRPF19/TRA2B/CHERP/PRPF40A/THOC7/SRSF2/RBMXL1/LSM5/TRA2A/MAGOHB/TXNL4A/SRSF6	4.25236136942871
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	30/1231	110/9376	2.07724687984639	CCNB1/HSP90AB1/HSP90AA1/CDK1/CCNB2/AURKA/CCNA2/MAD2L1/PIK3CB/GNAI1/ANAPC11/ANAPC10/PKMYT1/PLK1/MAPK3/AKT1/CDK2/ADCY5/CPEB4/CDC23/BUB1/ANAPC15/CDC25C/CDC25A/ANAPC4/KIF22/MAPK9/ANAPC1/RPS6KA1/BRAF	4.41809001327916
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	23/1231	75/9376	2.33574871378283	GAPDH/ALDOA/ENO1/TPI1/PKM/IDH2/PHGDH/IDH1/PFKP/GPT2/TALDO1/ARG2/IDH3B/BCAT2/GOT1/TKT/PGK1/PSAT1/IDH3G/MAT2A/SHMT1/GOT2/RPIA	4.51502016723674
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	29/1231	110/9376	2.00800531718485	GAPDH/RPS6/FLT1/ALDOA/ENO1/LDHB/LDHA/PIK3CB/EGLN3/PFKP/EPAS1/RBX1/MAPK3/TFRC/SLC2A1/MKNK1/ERBB2/ARNT/PGK1/AKT1/HK1/HMOX1/NOS2/RPS6KB2/EP300/ANGPT4/HK2/PDHA1/MKNK2	4.13411104594862
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	22/1231	75/9376	2.23419442187923	CCNE1/CCNB1/PERP/RRM2/CDK1/CCNB2/CCND3/SIVA1/GTSE1/CASP3/SHISA5/APAF1/CASP8/CDK2/EI24/SESN2/CCNE2/SFN/MDM2/PPP1R13L/RPRM/TNFRSF10B	4.17175225218431
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	19/1231	63/9376	2.29706136448622	CDK7/RPA3/RBX1/MNAT1/GTF2H3/RPA2/PCNA/RFC3/LIG1/CUL4A/POLD2/POLE3/CUL4B/POLR2D/ERCC2/UVSSA/RPA1/POLR2F/POLR2I	4.0156431917938
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/1231	23/9376	3.31155299685657	RPA3/SSBP1/RPA2/PCNA/RFC3/LIG1/POLD2/EXO1/MSH6/RPA1	4.31480751155174
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	14/1231	41/9376	2.60078064631174	RPA3/SSBP1/BABAM1/RAD51/RPA2/XRCC2/POLD2/BLM/TOPBP1/BRCC3/RPA1/RAD54L/BRCA2/RAD52	3.9933347052139
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	12/1231	33/9376	2.76966250646186	IDH2/IDH1/GPT2/IDH3B/BCAT2/GOT1/IDH3G/DHTKD1/GOT2/BCKDHB/PDHA1/DLAT	3.95888936846255
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/1231	30/9376	2.79274302734904	IDH2/IDH1/SDHB/IDH3B/ACLY/FH/IDH3G/SUCLG1/SDHA/PDHA1/DLAT	3.82326940442235
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	14/1231	44/9376	2.42345469315412	HMGB1/PCNA/NEIL2/RFC3/LIG1/POLD2/POLE3/SMUG1/NTHL1/LIG3/NEIL3/FEN1/PARP2/PARP1	3.6791859844346
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	16/1231	54/9376	2.25676204230225	LDHB/LDHA/PHGDH/SMS/BCAT2/GOT1/APIP/ENOPH1/CISD1/PSAT1/MAT2A/AMD1/MTAP/DNMT1/GOT2/DNMT3B	3.60051401945825
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	22/1231	85/9376	1.9713480193052	RRM2/TYMS/TK1/PNP/AK5/ADSL/NME6/APRT/GMPS/UCKL1/IMPDH1/ENTPD6/ITPA/CDA/ADK/HDDC2/AK2/IMPDH2/UPP1/UCK2/RRM1/NME2	3.4972140307193
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	22/1231	87/9376	1.92602967403382	UQCRH/TPM1/MT-CO3/MT-CYB/MT-CO2/MT-CO1/COX4I1/COX5B/COX5A/UQCR10/COX7B/COX7C/MYL4/COX8C/TPM3/COX6B1/TNNC1/TNNT2/COX6A1/MYL3/ATP1A4/COX7A2	3.37341031698184
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1231	71/9376	2.03823754876946	SLC16A3/PKM/LDHB/IDH2/LDHA/PIK3CB/IDH1/PFKP/MAPK3/SLC7A5/FGFR3/SLC2A1/ERBB2/AKT1/HK1/NRAS/HK2/MET/PDHA1	3.41379027945011
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	18/1231	67/9376	2.04624319507257	GAPDH/ALDOA/ENO1/TPI1/PKM/LDHB/LDHA/PFKP/PGM2/BPGM/PGK1/HK1/PGM1/ALDH3B2/HK2/ACSS2/PDHA1/DLAT	3.34108598656667
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	31/1231	142/9376	1.66277273715404	UBA52/RPS27A/UBE2C/SKP2/UBE2S/CDC20/UBB/ANAPC11/RBX1/ANAPC10/SAE1/UBE2F/CUL4A/CUL1/FBXW7/CUL4B/HERC4/NEDD4/TRIM37/CDC23/UBE4B/PRPF19/ANAPC15/UBE2Q2/UBE2A/ANAPC4/MID1/UBE2N/MDM2/ANAPC1/UBE2K	3.09373416254845
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	18/1231	70/9376	1.95854705814088	PIK3CB/EGLN3/EPAS1/RBX1/RAC1/MAPK3/SLC2A1/CDC42/ARNT/AKT1/FH/NRAS/EP300/GRB2/CRKL/MET/PAK6/BRAF	3.12932057006741
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/1231	30/9376	2.53885729759003	TYMS/FOLR1/ABCG2/GGH/TNF/SLC19A1/GART/SHMT1/DHFR/SLC46A1	3.28182340351814
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	35/1231	170/9376	1.56811774262914	EZR/TUBA1C/TUBA1B/CLDN7/CLDN4/ARPC3/F11R/CLDN19/ARPC1B/CLDN6/PRKCZ/RAB8B/PCNA/RAC1/RAB8A/CLDN3/CDC42/ERBB2/PARD6B/HSPA4/DLG1/HCLS1/PRKAB2/NEDD4/ARPC5L/PPP2R1B/TIAM1/TJP3/CRB3/ACTN4/MAPK9/MYH10/RAPGEF2/MARVELD3/SCRIB	2.90600561090958
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	32/1231	154/9376	1.58266428940678	UGP2/GGH/AK5/QPRT/GCH1/PTS/ALAS2/ADSL/NME6/BCAT2/OXSM/FLAD1/PSAT1/UMPS/MAT2A/PPCDC/HMBS/NFS1/KMO/SHMT1/ALAS1/DHFR/AK2/CPOX/EARS2/NADK2/MTHFD2/PDXK/FECH/NME2/DHODH/ALAD	2.83423151931272
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	43/1231	224/9376	1.46210978298712	HLA-G/CCNE1/CALR/PTTG1/RANBP1/SLC25A5/RAN/CDC20/CCNB2/CCNA2/MAD2L1/MSX2/PIK3CB/ANAPC11/CCND3/ANAPC10/VDAC1/MAPK3/PPP3R1/SLC2A1/BUB3/AKT1/TNF/BUB1B/CDK2/ADCY5/NRAS/DLG1/NFYB/EP300/IL2RB/CDC23/TBPL1/TCF3/XPO1/CCNE2/ANAPC15/PPP3CA/ANAPC4/MAPK9/ANAPC1/CREB3L4/EGR2	2.72132421746995
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	10/1231	32/9376	2.38017871649066	AKR1B1/B4GALT1/UGP2/PFKP/PGM2/GAA/HK1/GALK1/PGM1/HK2	3.04027606559729
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/1231	32/9376	2.38017871649066	LDHB/LDHA/MCEE/ACOX1/SUCLG1/ACOX3/PCCB/BCKDHB/EHHADH/ACSS2	3.04027606559729
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	11/1231	37/9376	2.26438623839111	CTNNB1/PPARG/CDH1/CCDC6/MAPK3/BAK1/NCOA4/TPM3/RXRA/NRAS/BRAF	2.99570852285756
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	32/1231	157/9376	1.55242229661556	HLA-G/CCNE1/CCNB1/CALM1/PPP1CB/SLC25A5/CDK1/CCNB2/CCNA2/PIK3CB/CCND3/RAD1/MYBL2/VDAC1/CAPN1/MAPK3/PPP3R1/AKT1/E2F4/CDK2/CALM3/TSC1/NRAS/FOXM1/CCNE2/PPP1CC/CDC25A/MAP2K6/PPP3CA/ITPR3/MDM2/RAD9A	2.71361504305187
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	41/1231	214/9376	1.45924975515689	HLA-G/CCNB1/CALM1/CALR/WEE1/CDK1/CCNB2/RAC3/AP1M2/PIK3CB/GNAI1/RBX1/AP1S1/LIMK2/RAC1/CASP3/MAPK3/BAK1/PPP3R1/CUL4A/CUL1/AKT1/AP1G1/TNF/AP1B1/GNG12/CASP8/CUL4B/CALM3/NRAS/RPS6KB2/TBK1/CDC25C/MAP2K6/PPP3CA/CRKL/ITPR3/MAPK9/IRF3/TRAF2/PAK6	2.64198164914649
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	32/1231	158/9376	1.54259683904205	RPS6/SKP2/ATP6V1C2/WNT7A/ATP6V1B1/PIK3CB/MAPK3/TELO2/SLC7A5/NPRL2/NPRL3/AKT1/TNF/SLC38A9/DVL3/MIOS/TSC1/NRAS/ATP6V1A/SESN2/STRADB/RPS6KB2/MLST8/TTI1/ATP6V1E1/PRR5/GRB2/TBC1D7/RPS6KA1/FZD6/RICTOR/BRAF	2.67397025147674
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	39/1231	205/9376	1.44900636008797	HLA-G/CCNE1/RANBP1/SKP2/PKM/YWHAE/CDC20/CDK1/CCNA2/PIK3CB/HNRNPK/CCND3/GTF2H3/YWHAZ/RAC1/CASP3/MAPK3/BAK1/HDAC1/CDC42/HDAC8/CASP8/CDK2/NRAS/DLG1/EP300/YWHAB/TBPL1/CCNE2/DNAJA3/GTF2B/GRB2/ACTN4/MDM2/IRF3/TRAF2/CREB3L4/EGR2/SCRIB	2.52691246002885
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1231	20/9376	2.66580016246954	SQLE/DHCR24/NSDHL/CYP51A1/MSMO1/EBP/FDFT1	2.89909142729291
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1231	78/9376	1.7576704367931	ENO1/HSPD1/LSM7/LSM4/LSM3/MPHOSPH6/PFKP/EXOSC3/EXOSC10/PARN/HSPA9/CNOT6/CNOT1/CNOT7/PAN3/EXOSC9/BTG3/LSM5	2.61217334057506
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	22/1231	103/9376	1.62684059845575	PPP1CB/RBM8A/PAPOLA/UPF1/SAP18/RNPS1/NUDT21/PABPN1/CSTF3/PPP2R5A/CPSF3/PPP2R1B/NXT2/NCBP1/TARDBP/DAZAP1/GSPT1/NXF1/PPP1CC/CPSF4/MAGOHB/UPF3B	2.48676484606295
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/1231	46/9376	1.98693179811394	POMP/PSMA7/PSMA4/PSMD6/ADRM1/PSMD12/PSMB6/PSMB3/PSMC3/PSMD14/PSMB2/PSMB1	2.608521112534
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/1231	57/9376	1.87073695611897	TECR/SCD/ELOVL2/ACOX1/OXSM/HADH/HSD17B8/ACAT2/MECR/ELOVL5/ACOX3/ACSL4/EHHADH/CPT2	2.5633556710027
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1231	31/9376	2.21126280757842	GCSH/GLDC/MCEE/GLYCTK/SHMT1/ACAT2/PCCB/PGP/ACSS2	2.62602403439034
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1231	37/9376	2.05853294399192	UGP2/GFPT1/TGDS/PGM2/HK1/GALK1/CMAS/PGM1/HK2/GMDS	2.50798060415238
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	18/1231	82/9376	1.67193041548612	MGST3/GSTP1/RRM2/TK1/NME6/GSTA3/GMPS/UCKL1/GSTM4/IMPDH1/ITPA/UMPS/CDA/IMPDH2/UPP1/UCK2/RRM1/NME2	2.37574056232716
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	22/1231	106/9376	1.58079794000889	CCNE1/HSP90AB1/HSP90AA1/GSTP1/CTNNB1/FOLR1/SPINT1/PIK3CB/MAPK3/ERBB2/AKT1/SLC19A1/CDK2/NRAS/EP300/CCNE2/GRB2/MDM2/ETV5/SLC46A1/BRAF/CREB3L4	2.33779945595548
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/1231	59/9376	1.80732214404714	RRM2/TYMS/TK1/NME6/UCKL1/ENTPD6/UMPS/CDA/HDDC2/UPP1/UCK2/RRM1/NME2/DHODH	2.41826529534802
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/1231	59/9376	1.80732214404714	MGST3/PRDX6/GSTP1/GPX3/RRM2/IDH2/IDH1/SMS/GSTA3/GSTM4/ODC1/GGCT/GSR/RRM1	2.41826529534802
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	27/1231	137/9376	1.50107621244374	TUBA1C/TUBA1B/BIRC5/CTSV/LMNB1/PIK3CB/CAPN1/CASP3/AIFM1/MAPK3/BAK1/DFFA/AKT1/CSF2RB/TNF/APAF1/LMNB2/CASP6/CASP8/NRAS/BCL2A1/ITPR3/MAPK9/PARP2/TRAF2/PARP1/TNFRSF10B	2.29678692074239
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	45/1231	253/9376	1.35472622598678	UBA52/RPS27A/PFN1/ARPC3/PIK3CB/ARPC1B/UBE2V1/UBB/BNIP3/RBX1/VDAC1/CAPN1/CASP4/RAC1/MAPK3/CBX3/CUL1/CDC42/AKT1/HK1/ATG12/TNF/TIFA/FOXO4/HCLS1/RPS6KB2/ARPC5L/TBK1/U2AF1/PLCD4/ELMO1/TECPR1/DIAPH1/HK2/CRKL/ACTN4/ITPR3/PLCB3/UBE2N/MDM2/GLMN/MAPK9/IRF3/ARF6/TRAF2	2.2235855436535
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	13/1231	54/9376	1.83361915937058	UBE2T/RPA3/FANCE/RAD51/RPA2/TELO2/FANCI/BLM/RMI2/FANCD2/RPA1/FANCB/BRCA2	2.38824643741184
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/1231	144/9376	1.48100009026085	SLC25A5/PSMA7/PSMA4/PIK3CB/PSMD6/VDAC1/ADRM1/PSMD12/PPIF/AKT1/PUM1/PSMB6/ATXN2L/TBPL1/PSMB3/PSMC3/PSMD14/GRIN2D/GTF2B/OMA1/AFG3L2/PSMB2/ITPR3/VLDLR/PLCB3/MAPK9/TRAF2/PSMB1	2.26124503533217
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	18/1231	83/9376	1.6517866755405	PRDX1/ECH1/IDH2/IDH1/SOD1/SLC27A2/ACOX1/PMVK/PXMP2/NOS2/MPV17L2/NUDT7/ACOX3/FAR2/ACSL4/HACL1/EHHADH/ABCD1	2.31865255749132
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/1231	44/9376	1.90414297319253	CDK7/MNAT1/GTF2H3/TAF13/TAF11/TAF3/TBPL1/ERCC2/GTF2B/TAF15/TAF9	2.33692731556072
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/1231	23/9376	2.3180870977996	HMGCS1/ICMT/PMVK/MVD/PDSS2/ACAT2/NUS1	2.46037712230659
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1231	19/9376	2.40523322929582	GCSH/GLDC/DHTKD1/BCKDHB/PDHA1/DLAT	2.38355960679872
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/1231	156/9376	1.41590118519444	CLDN7/CTNNB1/CLDN4/YWHAE/CLDN19/PIK3CB/EIF3E/CLDN6/YWHAZ/CASP3/MAPK3/BAK1/CLDN3/AKT1/RXRA/TNF/APAF1/OAS3/CASP8/CDK2/NRAS/TBK1/YWHAB/IFNAR2/PPP2R1B/GRB2/IRF3/TRAF2/BRAF	2.0363673115005
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1231	75/9376	1.62486867045762	MGST3/GSTP1/TOP2A/BIRC5/PIK3CB/CASP3/GSTA3/MAPK3/BAK1/GSTM4/ERBB2/AKT1/APAF1/CASP8/MSH6/MDM2	2.11214476186968
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	11/1231	46/9376	1.82135414827111	ALAS2/HCCS/HMOX1/CP/HMBS/ALAS1/CPOX/EARS2/FECH/ALAD/BLVRB	2.17088925569832
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1231	35/9376	1.95854705814088	ALDOA/AKR1B1/TPI1/PFKP/HK1/PFKFB4/ENOSF1/HK2/GMDS	2.20861437820486
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	38/1231	216/9376	1.33995246261696	CALM1/HSP90AB1/HSP90AA1/PPARG/HSPD1/HSPA8/CCL3L1/CCL3/PIK3CB/CCL2/RAC1/CASP3/MAPK3/PPP3R1/CDC42/HSPA2/AKT1/RXRA/TNF/APAF1/CASP6/CASP8/CYP2J2/CALM3/HSPA4/CXCL1/NRAS/TBK1/VAV3/MAP2K6/PPP3CA/VLDLR/PLCB3/MAPK9/IRF3/TRAF2/POU2F1/TNFRSF10B	1.96501762750593
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1231	41/9376	1.85770046165125	GCSH/GLDC/PHGDH/ALAS2/BPGM/PSAT1/GLYCTK/SHMT1/ALAS1/GAMT	2.13963420165119
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/1231	101/9376	1.50823205797428	COL3A1/FN1/COL4A1/COL1A1/COL4A2/PIK3CB/CCL2/PRKCZ/RAC1/CASP3/MAPK3/CDC42/AKT1/TNF/NRAS/COL1A2/PLCD4/DIAPH1/PLCB3/MAPK9	1.99634181654988
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	16/1231	77/9376	1.58266428940678	RALBP1/RAC3/RALB/PIK3CB/RAD51/RAC1/MAPK3/BAK1/CDC42/ERBB2/AKT1/RPS6KB2/PLD2/MAPK9/BRCA2/BRAF	1.99578962546849
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1231	31/9376	1.9655669400697	ALDOA/PFKP/TALDO1/TKT/PGM2/GLYCTK/PGM1/RPIA	2.09335412230233
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	24/1231	128/9376	1.42810722989439	RRM2/PNP/AK5/NUDT5/ADSL/NME6/APRT/GMPS/IMPDH1/ENTPD6/PGM2/ITPA/HDDC3/GART/ADCY5/ADK/PAICS/PGM1/HDDC2/AK2/IMPDH2/PDE6H/RRM1/NME2	1.8958446917696
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/1231	78/9376	1.56237372159387	FN1/CTNNB1/ARPC3/CDH1/PIK3CB/CLTA/ARPC1B/RAC1/CDC42/HCLS1/ARPC5L/ELMO1/CD2AP/CRKL/ARHGAP10/MET	1.93886097655494
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	35/1231	200/9376	1.33290008123477	EZR/TUBA1C/TUBA1B/GAPDH/RPS3/CLDN7/CLDN4/NCL/TUBB4B/ARPC3/CLDN19/BAIAP2L1/ARPC1B/CLDN6/CASP4/RAC1/CASP3/MAPK3/BAK1/TUBB/CLDN3/CDC42/TNF/SEC24A/MYO1B/CASP8/HCLS1/ARPC5L/CYFIP2/MAPK9/MYO1G/ARF6/TRAF2/MYH10/TNFRSF10B	1.84999824692786
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/1231	67/9376	1.59152248505644	CALM1/PPP1CB/MAPK3/PPP3R1/CALM3/NRAS/EP300/PPP1CC/GRIN2D/PPP3CA/ITPR3/PLCB3/RPS6KA1/BRAF	1.88897523526936
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1231	27/9376	1.97466678701447	TECR/SCD/ELOVL2/ACOX1/ACOT7/ELOVL5/ACOX3	1.97162624117725
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/1231	50/9376	1.67564581640942	CKMT1A/CKMT1B/ARG2/SMS/GOT1/ODC1/NOS2/AMD1/GAMT/CNDP2/GOT2	1.86219651226011
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1231	28/9376	1.90414297319253	TECR/ELOVL2/THEM4/ACOT7/HADH/MECR/ELOVL5	1.86262700647529
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	38/1231	227/9376	1.27502084548574	HLA-G/CALM1/CALR/CTNNB1/CCL4/GNAS/CCL3L1/RAC3/CCL3/PIK3CB/GNAI1/CCL2/RAC1/CASP3/MAPK3/BAK1/PPP3R1/AKT1/TNF/GNG12/CASP8/CALM3/ADCY5/TSC1/NRAS/RPS6KB2/TBK1/MAP2K6/GRB2/CCL4L2/PPP3CA/CRKL/ITPR3/PLCB3/MDM2/IRF3/TRAF2/CREB3L4	1.63065034999685
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	15/1231	76/9376	1.50327076830989	PPARG/PLIN2/SCD/FABP7/HMGCS1/SLC27A2/SLC27A6/PLTP/ACOX1/DBI/RXRA/ACOX3/ACSL4/EHHADH/CPT2	1.71252195520125
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/1231	149/9376	1.3290662363223	MT-ND1/MT-ND3/MT-ND4/MT-ND2/MT-ND5/MT-ND6/GNAI1/NDUFAB1/MT-ND4L/NDUFB11/NDUFV3/MAPK3/NDUFA6/NDUFS3/NDUFA11/NDUFA9/GNG12/NDUFS5/ADCY5/NDUFS4/NDUFA3/ITPR3/PLCB3/MAPK9/NDUFV2/NDUFB2	1.57403838231495
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	35/1231	212/9376	1.25745290682525	PGF/CALM1/FLT1/EFNA1/CTNNB1/PFN1/GNAS/ID1/RAC3/CDH1/RALB/PIK3CB/GNAI1/FLT4/PRKCZ/RAC1/MAPK3/FGFR3/CDC42/AKT1/PRKD3/PARD6B/CALM3/ADCY5/NRAS/ANGPT4/CTNND1/TIAM1/VAV3/MAP2K6/CRKL/PLCB3/MET/RAPGEF2/BRAF	1.4739824418992
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	24/1231	138/9376	1.32462119874263	CALM1/RPS6/PPP1CB/PTPRF/PIK3CB/PRKCZ/MAPK3/MKNK1/AKT1/HK1/PHKG2/CALM3/TSC1/NRAS/PRKAB2/RPS6KB2/INPP5A/PPP1CC/GRB2/HK2/CRKL/MAPK9/MKNK2/BRAF	1.49347020145847
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1231	36/9376	1.69257153172669	UGP2/PGM2/GAA/HK1/AGL/PGM1/HK2/GYG2	1.61849576905701
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/1231	93/9376	1.39227658254937	CTNNB1/PTPRF/RAC3/CDH5/CDH1/ARHGAP29/CSNK2A2/RAC1/MAPK3/PDCD10/CDC42/ERBB2/EP300/CTNND1/ACTN4/SSX2IP/MET	1.47794680342831
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/1231	93/9376	1.39227658254937	CCNE1/FN1/COL4A1/CKS1B/SKP2/CKS2/COL4A2/PIK3CB/CASP3/BAK1/AKT1/RXRA/APAF1/NOS2/CDK2/CCNE2/TRAF2	1.47794680342831
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1231	87/9376	1.40074885384278	CTNNB1/BIRC5/RAC3/RALB/PIK3CB/RAC1/CASP3/MAPK3/BAK1/AKT1/NRAS/RPS6KB2/MSH6/GRB2/MAPK9/BRAF	1.45987796717463
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	52/1231	333/9376	1.189374589862	HLA-G/CCNE1/FN1/CTNNB1/COL4A1/PKM/GNAS/COL1A1/CCNA2/ATP6V1C2/WNT7A/COL9A3/ATP6V1B1/COL4A2/PIK3CB/ISG15/CCND3/PRKCZ/CASP3/MAPK3/BAK1/HDAC1/CDC42/AKT1/HEY1/TNF/PARD6B/CASP8/DVL3/PPP2R5A/CDK2/TSC1/NRAS/DLG1/ITGB4/ATP6V1A/RPS6KB2/COL1A2/EP300/TBK1/IFNAR2/PPP2R1B/TBPL1/ATP6V1E1/CCNE2/GRB2/CRB3/MDM2/IRF3/FZD6/CREB3L4/SCRIB	1.3679073306424
NA	NA	hsa04981	Folate transport and metabolism	7/1231	31/9376	1.71987107256099	TYMS/FOLR1/ABCG2/SLC19A1/SHMT1/DHFR/SLC46A1	1.56068421021433
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	19/1231	107/9376	1.35247538282834	CALM1/PKM/GNAS/LDHB/LDHA/PFKP/PPP3R1/SLC2A1/AKT1/PHKG2/PPP4C/CALM3/PRKAB2/EP300/PPP3CA/ITPR3/PLCB3/PDHA1/CREB3L4	1.42552014502248
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1231	37/9376	1.64682635519354	GPT2/ADSL/GFPT1/GOT1/NIT2/GOT2/RIMKLA/RIMKLB	1.53252476674203
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	17/1231	94/9376	1.37746512954353	HSP90AB1/HSP90AA1/S100A9/FOSB/S100A8/CCL2/CASP3/MAPK3/CCL20/SRSF1/TNFAIP3/TNF/CASP8/CXCL1/TBK1/MAPK9/TRAF2	1.42984546585721
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1231	20/9376	1.90414297319253	UGP2/CYB5R1/TGDS/CMAS/GMDS	1.57353396985127
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	33/1231	204/9376	1.23209251206575	EZR/RPS6/FN1/IGF2/CTNNB1/PPP1CB/GPC3/SDC4/COL1A1/WNT7A/PIK3CB/RAC1/CASP3/ERBB3/MAPK3/CDC42/ERBB2/SDC1/AKT1/TNF/NRAS/HCLS1/RPS6KB2/COL1A2/TIAM1/PPP1CC/VAV3/GRB2/ITPR3/MDM2/MET/FZD6/BRAF	1.30290667842845
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	33/1231	205/9376	1.22608230468982	HLA-G/CCNE1/CALR/SKP2/CCNA2/PIK3CB/ISG15/CCND3/PSMD6/RAC1/CASP3/ADRM1/BAK1/PSMD12/HDAC1/TNFAIP3/AKT1/TNF/APAF1/OAS3/CASP8/CDK2/NEDD4/TBK1/IFNAR2/PSMC3/PSMD14/CCNE2/MAP2K6/MDM2/MAPK9/IRF3/TRAF2	1.27234320823612
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1231	39/9376	1.56237372159387	GCSH/TYMS/GLDC/GART/MAT2A/SHMT1/DHFR/MTHFD2	1.36811550041705
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1231	16/9376	1.90414297319253	MIF/GOT1/ALDH3B2/GOT2	1.40711080749334
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1231	28/9376	1.63212254845074	AKR1B1/GGH/GCH1/PTS/PCBD2/DHFR	1.30223710746642
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1231	47/9376	1.45849249010491	PKM/LDHB/LDHA/FH/ACAT2/ACYP1/ACSS2/PDHA1/DLAT	1.22499052427212
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1231	47/9376	1.45849249010491	PKM/PIK3CB/PRKCZ/MAPK3/HK1/TNF/ABCC8/HK2/MAPK9	1.22499052427212
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1231	142/9376	1.23367009530783	CALM1/MGST3/HSP90AB1/HSP90AA1/GSTP1/CTNNB1/SDC4/RAC3/CDH5/PIK3CB/CCL2/PRKCZ/RAC1/GSTA3/GSTM4/SDC1/AKT1/HMOX1/TNF/CALM3/MAP2K6/TXN2/MAPK9	1.09074063565741
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	36/1231	233/9376	1.17680939115761	DSP/DSC2/COL3A1/TPM1/FN1/ENO1/COL4A1/TNNI2/DSG2/CSRP2/SDC4/COL1A1/LMNB1/DIAPH3/PKP2/COL9A3/COL4A2/COL27A1/JUP/MYL4/FBN2/FHL2/SDC1/TPM3/LMNB2/TNNC1/SYNE2/ITGB4/ACTG2/COL1A2/TNNT2/MYL3/DIAPH1/ATP1A4/MYH10/NEBL	1.06244889614321
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1231	61/9376	1.37348017738477	MT1E/MT1G/MT1H/MT2A/MT1X/MT1F/SLC6A19/HMOX1/MT1A/ATP1A4/SLC46A1	1.13765391223257
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1231	48/9376	1.42810722989439	HMGCS1/BCAT2/MCEE/HADH/HIBADH/ACAT2/PCCB/BCKDHB/EHHADH	1.1559739108298
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/1231	122/9376	1.24861834307707	DIO2/CTNNB1/PIK3CB/PFKP/MAPK3/SLC2A1/HDAC1/AKT1/RXRA/NRAS/EP300/PLCD4/MED12L/THRB/MED24/PLCB3/NCOA2/MDM2/ATP1A4/MED30	1.07452730490241
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1231	23/9376	1.65577649842828	GPT2/ARG2/GOT1/NOS2/GOT2	1.22409019614316
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	30/1231	193/9376	1.18392309214043	CCL4/CCL3L1/RAC3/CXCL14/CCR7/CCL3/PIK3CB/GNAI1/CCL2/PRKCZ/CXCL13/RAC1/MAPK3/CCL20/CDC42/AKT1/GNG12/CXCL1/ADCY5/NRAS/TIAM1/VAV3/ELMO1/GRB2/CCL4L2/CRKL/PLCB3/PREX1/CXCR6/BRAF	1.00367184716566
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	45/1231	300/9376	1.14248578391552	PGF/FLT1/EFNA1/IGF2/DUSP9/HSPA8/STMN1/RAC3/IL1RAP/FLT4/RAC1/CASP3/ERBB3/MAPK3/FGFR3/PPP3R1/MKNK1/NF1/CDC42/ERBB2/AKT1/ECSIT/TNF/TAOK3/GNG12/RPS6KA4/NRAS/ANGPT4/STK3/MAP3K8/RASGRF2/DUSP5/MAP2K6/GRB2/PPP3CA/CRKL/MAPK9/MET/TRAF2/RASA1/MKNK2/RAPGEF2/PPP5C/RPS6KA1/BRAF	0.975110965320908
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1231	69/9376	1.32462119874263	CALM1/PPP1CB/GNAS/FOSB/PPP3R1/HDAC1/CALM3/ADCY5/PPP1CC/GRIN2D/PPP3CA/CREB3L4	1.05212099235213
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1231	103/9376	1.25710409880672	COL3A1/PRDX1/FN1/COL4A1/SERPINB9/GNAS/COL1A1/COL4A2/PIK3CB/ARG2/CASP3/TNF/NOS2/CXCL1/COL1A2/ACTN4/PLCB3	1.01996813267412
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	18/1231	110/9376	1.24634812790784	ID3/ID1/BMP7/RBX1/MAPK3/TFRC/CUL1/HDAC1/LRRC32/E2F4/GREM2/PITX2/TNF/RPS6KB2/EP300/PPP2R1B/TMEM53/SMAD6	1.01034240531272
Cellular Processes	Cell motility	hsa04814	Motor proteins	30/1231	194/9376	1.17782039578919	TUBA1C/TUBA1B/TPM1/TNNI2/TUBB4B/KIF2C/KIF2A/KIF21A/CENPE/KIF11/MYL4/KIF4A/TUBB/KIFC1/TPM3/DCTN5/TNNC1/KIF23/MYO1B/KIF20A/KIF20B/ACTG2/TNNT2/KIF14/KIF18A/MYL3/KIF22/MYO1G/MYH10/KIF18B	0.972932954252583
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	28/1231	180/9376	1.18480007220868	HLA-G/CALR/PPP1CB/SRSF3/PIK3CB/CCL2/CASP3/EIF2B5/BAK1/SRSF1/AKT1/HCFC1/TNF/APAF1/OAS3/CASP8/TSC1/SRSF9/TBK1/IFNAR2/SRPK1/NXF1/PPP1CC/SRSF2/IRF3/TRAF2/SRSF6/POU2F1	0.973213283817922
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	22/1231	138/9376	1.21423609884741	FN1/RAC3/ARPC3/PIK3CB/ARPC1B/CCL2/RAC1/MAPK3/CDC42/AKT1/TNF/ARPC5L/TBK1/VAV3/MAP2K6/ELMO1/CRKL/MAPK9/IRF3/ARF6/TRAF2/RPS6KA1	0.985626419175996
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	10/1231	56/9376	1.36010212370895	B4GALT1/TUSC3/MOGS/ALG3/DPM1/STT3A/ALG12/MAN1A2/ALG8/GANAB	1.05070514846072
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	27/1231	174/9376	1.18188184542984	CALR/HSP90AB1/HSP90AA1/HSPA8/DNAJA1/TUSC3/NSFL1C/RBX1/WFS1/SEC23B/DNAJB11/CAPN1/MOGS/ERP29/BAK1/EDEM2/STT3A/DNAJA2/CUL1/SEC24A/MAN1A2/P4HB/UBE4B/GANAB/MAPK9/TRAF2/EDEM1	0.941438559211626
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1231	50/9376	1.37098294069862	HBA2/HBA1/HBB/GYPB/GYPA/CCL2/SDC1/TNF/MET	1.02249303036953
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1231	18/9376	1.69257153172669	OXSM/HSD17B8/MECR/ACSL4	1.1433481365954
NA	NA	hsa04382	Cornified envelope formation	33/1231	217/9376	1.15828051825536	KRT8/KRT18/KRT7/KRT19/DSP/S100A10/S100A11/CLDN7/CLDN4/COL4A1/S100A9/KRT23/DSG2/PRSS8/PKP3/CLDN19/PKP2/S100A8/COL4A2/PADI1/JUP/PCSK6/CLDN6/CAPN1/CLDN3/BLMH/PPP2R5A/FURIN/ITGB4/PPP2R1B/S100A12/TCHH/KRT15	0.917069862116559
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	31/1231	203/9376	1.16312181613731	PGF/FN1/FLT1/CTNNB1/COL4A1/PPP1CB/RAC3/COL1A1/COL9A3/COL4A2/PIK3CB/FLNB/CCND3/FLT4/RAC1/MAPK3/CDC42/ERBB2/AKT1/ITGB4/COL1A2/PPP1CC/VAV3/GRB2/DIAPH1/CRKL/ACTN4/MAPK9/MET/PAK6/BRAF	0.913426255113039
NA	NA	hsa04518	Integrin signaling	24/1231	154/9376	1.18699821705508	PGF/FN1/FLT1/CTNNB1/COL4A1/RAC3/COL1A1/CDH1/COL9A3/COL4A2/PIK3CB/FLNB/CCND3/FLT4/RAC1/ICAM3/CDC42/ERBB2/AKT1/ITGB4/COL1A2/FERMT1/ACTN4/MET	0.909608243491969
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/1231	119/9376	1.21609131061035	PIK3CB/CCL2/CASP3/MAPK3/CCL20/FRMD8/TNFAIP3/AKT1/TNF/RPS6KA4/CASP8/DNM1L/CXCL1/ADAM17/MAP3K8/MAP2K6/MAPK9/TRAF2/CREB3L4	0.922241736864433
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/1231	71/9376	1.28730792553861	F11R/ATP6V1C2/ATP6V1B1/RAC1/CASP3/CDC42/CXCL1/ATP6V1A/ADAM17/ATP6V1E1/MAPK9/MET	0.94468650702833
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1231	99/9376	1.23096111398305	RAC3/PIK3CB/LYPLA1/RAC1/MAPK3/SLC44A1/AKT1/DGKZ/TSC1/NRAS/RPS6KB2/PLD2/SLC44A2/SLC22A3/GRB2/MAPK9	0.898094020625383
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	37/1231	248/9376	1.1363433872278	S100A10/TUBA1C/TUBA1B/GAPDH/HSP90AB1/HSP90AA1/RPS3/CTNNB1/PFN1/TUBB4B/ARPC3/PIK3CB/ARPC1B/CASP4/RAC1/CASP3/MAPK3/BAK1/TUBB/GSDMD/PIK3C2A/CDC42/AKT1/DCTN5/TNF/CASP8/VPS33A/FBXO22/ARPC5L/MAP2K6/ELMO1/TXN2/CYFIP2/MAPK9/ARF6/TRAF2/TNFRSF10B	0.845943239789341
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/1231	38/9376	1.40305271708923	UGP2/GFPT1/PGM2/HK1/GALK1/PGM1/HK2	0.96782277333687
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	25/1231	163/9376	1.16818587312425	CCNE1/BIRC5/CCNA2/PIK3CB/YWHAZ/PCNA/CASP3/MAPK3/AKT1/TNF/APAF1/CASP8/CDK2/NRAS/EP300/TBK1/YWHAB/CCNE2/MAP2K6/GRB2/MAPK9/IRF3/BRAF/CREB3L4/EGR2	0.842077185511257
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1231	32/9376	1.42810722989439	BIRC5/CASP3/BAK1/APAF1/CASP8/MAPK9	0.943040309929237
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1231	13/9376	1.7576704367931	XRCC4/DCLRE1C/FEN1	1.06270720940035
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1231	59/9376	1.2909443886051	CTNNB1/CDH1/PIK3CB/MAPK3/BAK1/ERBB2/AKT1/NRAS/GRB2/BRAF	0.87149934264516
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1231	73/9376	1.25203921524988	RAN/SMARCB1/TNPO3/NELFCD/PPIA/FURIN/EP300/SUPT5H/PSIP1/NUP153/XPO1/CCNT1	0.84040215746755
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/1231	80/9376	1.23769293257514	RPS6/PIK3CB/ERBB3/MAPK3/FGFR3/NF1/ERBB2/AKT1/NRAS/RPS6KB2/GRB2/MET/BRAF	0.830008089532845
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1231	26/9376	1.46472536399425	PLA2G2A/PLA2G10/PLA2G12A/ACOX1/ACOX3	0.922457497702694
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/1231	130/9376	1.1717802911954	COL3A1/COL4A1/GNAS/COL1A1/COL4A2/PIK3CB/GNAI1/PRKCZ/MAPK3/AKT1/NOS2/GNG12/ADCY5/NRAS/COL1A2/RLN2/GRB2/PLCB3/MAPK9/CREB3L4	0.766720696489978
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	26/1231	173/9376	1.14468710527181	SLC25A5/KPNA2/PIK3CB/CCND3/CCL2/VDAC1/CASP3/MAPK3/BAK1/NUP98/RAB11A/AKT1/TNF/APAF1/OAS3/PABPN1/CASP8/EP300/TBK1/IFNAR2/NXT2/XPO1/NXF1/CPSF4/IRF3/TNFRSF10B	0.746719149303633
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	35/1231	238/9376	1.12008410187796	PGF/CALM1/FLT1/RALBP1/EFNA1/IGF2/PLA2G2A/RAC3/RALB/PIK3CB/FLT4/PLA2G10/RAC1/MAPK3/FGFR3/PLA2G12A/NF1/RGL2/CDC42/AKT1/GNG12/FOXO4/CALM3/NRAS/ANGPT4/TBK1/TIAM1/RASGRF2/PLD2/GRB2/MAPK9/MET/ARF6/RASA1/PAK6	0.729486965475965
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	34/1231	232/9376	1.11622174290596	EZR/FN1/PFN1/PPP1CB/RAC3/ARPC3/DIAPH3/PIK3CB/ARPC1B/LIMK2/RAC1/MAPK3/FGFR3/CDC42/AKT1/GNG12/NRAS/ITGB4/ARPC5L/TIAM1/IQGAP3/PPP1CC/VAV3/CYFIP2/DIAPH1/CRKL/ACTN4/MYH10/PAK6/BRAF/SSH3/FGD3/SPATA13/C7	0.696838902520657
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	18/1231	117/9376	1.1717802911954	ACTL6A/SMARCB1/DMAP1/CHRAC1/UCHL5/RUVBL1/HDAC1/ARID1A/POLE3/ARID2/MTA2/SMARCD2/ING3/SMARCA2/MBD3/RUVBL2/NFRKB/ACTR6	0.726864308035796
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/1231	89/9376	1.19811243257058	TUBA1C/TUBA1B/CDK1/GNAS/TUBB4B/GNAI1/MAPK3/TUBB/ADCY5/NRAS/GRB2/ITPR3/PLCB3/ADRB1	0.730025669899999
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1231	14/9376	1.63212254845074	B4GALT1/B3GNT2/B3GNT7	0.920131930976477
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/1231	139/9376	1.15070510610196	KRT18/KRT19/CALM1/HSP90AB1/HSP90AA1/KRT23/HSPA8/GNAS/PIK3CB/GNAI1/MAPK3/AKT1/CALM3/ADCY5/NRAS/GRB2/ITPR3/PLCB3/NCOA2/KRT15/CREB3L4	0.695887468367381
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1231	41/9376	1.30039032315587	CDH1/MAPK3/FGFR3/ERBB2/NRAS/MDM2/BRAF	0.749358823979157
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1231	48/9376	1.26942864879502	CLDN7/CLDN4/CLDN19/CD9/CLDN6/DPP4/CLDN3/EPCAM	0.727510462539941
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	20/1231	133/9376	1.14534915680753	CCNB1/SKP2/CCNB2/PLK2/PIK3CB/BNIP3/PLK1/MAPK3/AKT1/ATG12/FOXO4/CDK2/NRAS/PRKAB2/EP300/GRB2/MDM2/MAPK9/BRAF/PLK4	0.656297849218234
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1231	76/9376	1.20261661464791	EZR/CALM1/CA2/GNAS/GAST/GNAI1/CALM3/ADCY5/KCNQ1/ITPR3/PLCB3/ATP1A4	0.689460669925983
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/1231	69/9376	1.21423609884741	RAC3/PIK3CB/RAC1/MAPK3/AKT1/TNF/NRAS/VAV3/MAP2K6/GRB2/MAPK9	0.694354828920744
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1231	69/9376	1.21423609884741	CALM1/GNAS/GNAI1/PPP3R1/CALM3/ADCY5/ORAI1/PPP3CA/ITPR3/PLCB3/ADRB1	0.694354828920744
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1231	62/9376	1.22847933754357	HSPA8/PIK3CB/SOD1/HDAC1/AKT1/CLPB/ADCY5/NRAS/PRKAB2/RPS6KB2	0.701687563338666
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1231	21/9376	1.45077559862288	DSEL/CSGALNACT1/B4GALT7/XYLT2	0.80392821402052
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	25/1231	170/9376	1.12008410187796	MGST3/GSTP1/IGF2/CTNNB1/WNT7A/PIK3CB/ACTL6A/SMARCB1/GSTA3/MAPK3/BAK1/GSTM4/ARID1A/AKT1/HMOX1/DVL3/NRAS/RPS6KB2/ARID2/SMARCD2/SMARCA2/GRB2/MET/FZD6/BRAF	0.614247800505996
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/1231	98/9376	1.16580182032195	ARPC3/PIK3CB/ARPC1B/LIMK2/RAC1/MAPK3/ASAP1/CDC42/AKT1/RPS6KB2/ARPC5L/PLD2/VAV3/CRKL/ARF6	0.641422615570957
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1231	28/9376	1.36010212370895	CA2/ATP6V1C2/ATP6V1B1/ATP6V1A/ATP6V1E1	0.741847208457557
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/1231	178/9376	1.11253297310125	NOTUM/CTNNB1/RAC3/FRZB/WNT7A/RBX1/CCND3/CACYBP/CSNK2A2/RAC1/CTNNBIP1/TLE3/RUVBL1/PPP3R1/CUL1/CTBP1/DVL3/SENP2/RNF43/EP300/PPP3CA/PLCB3/MAPK9/GPC4/SFRP1/FZD6	0.589267123976036
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/1231	56/9376	1.22409191133805	HSPD1/HSPA8/BNIP3/CASP3/TNF/APAF1/CASP8/CXCL1/BCL2L13	0.653854863576429
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1231	15/9376	1.52331437855402	AK5/NFS1/AK2	0.788526502837469
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	23/1231	157/9376	1.11580352569244	CTNNB1/PPP1CB/BIRC5/YWHAE/ID1/CDH1/WNT7A/BMP7/CCND3/PRKCZ/YWHAZ/RASSF6/TEAD3/PARD6B/DVL3/DLG1/YWHAB/STK3/PPP2R1B/PPP1CC/FZD6/SCRIB/WWC1	0.568851386489429
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1231	187/9376	1.09971893638927	HSP90AB1/HSP90AA1/YWHAE/CCL2/VDAC1/CASP4/MAPK3/GSDMD/TNFAIP3/ATG12/TNF/OAS3/CASP8/DNM1L/DHX33/CXCL1/NEK7/TBK1/IFNAR2/SUGT1/BRCC3/TXN2/ITPR3/PLCB3/MAPK9/IRF3/TRAF2	0.535467893137031
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1231	136/9376	1.12008410187796	CCNE1/HSPA8/PIK3CB/CCND3/CSNK2A2/CASP3/BAK1/TNFAIP3/AKT1/APAF1/OAS3/CASP8/CDK2/IL2RB/TBK1/IFNAR2/CCNE2/EIF3H/MAPK9/IRF3	0.548388202474762
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1231	43/9376	1.23990705231141	ACOX1/HADH/ACAT2/ACOX3/ACSL4/EHHADH/CPT2	0.612965074347954
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/1231	93/9376	1.14658071504066	CGA/CALM1/GNAS/MAPK3/CDC42/CALM3/ADCY5/NRAS/PLD2/MAP2K6/GRB2/ITPR3/PLCB3/MAPK9	0.552259576217028
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/1231	122/9376	1.12375650876936	LEP/PPARG/SCD/CCNA2/PIK3CB/PFKP/RAB8A/ADIPOR2/AKT1/PPP2R5A/TSC1/PRKAB2/STRADB/RPS6KB2/PPP2R1B/PFKFB4/EEF2K/CREB3L4	0.534875046572288
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/1231	86/9376	1.1513422628606	PIK3CB/ERBB3/MAPK3/ERBB2/AKT1/NRAS/RPS6KB2/GRB2/CRKL/NRG4/MAPK9/PAK6/BRAF	0.548113769258024
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/1231	196/9376	1.08808169896716	HLA-G/CALM1/UBA52/RPS27A/CTNNB1/PIK3CB/UBB/RAC1/CASP3/MAPK3/BAK1/PPP3R1/AKT1/GNG12/CASP8/CALM3/CXCL1/NRAS/EP300/TBK1/IFNAR2/MAP2K6/PPP3CA/ITPR3/PREX1/MAPK9/IRF3/TRAF2	0.484463986325925
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1231	65/9376	1.1717802911954	CGA/KISS1/PIK3CB/KISS1R/MAPK3/AKT1/NRAS/KCNN4/ITPR3/PLCB3	0.540257705700893
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1231	51/9376	1.19475637533649	GNAS/ATP6V1C2/ATP6V1B1/KDELR2/KDELR3/ATP6V1A/ATP6V1E1/KCNQ1	0.542152508208004
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/1231	109/9376	1.11802890169102	CCL4/CCL3L1/CCL3/PIK3CB/RAC1/MAPK3/AKT1/TNF/CASP8/TBK1/IFNAR2/MAP3K8/MAP2K6/CCL4L2/MAPK9/IRF3	0.481838117762926
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	16/1231	109/9376	1.11802890169102	PPP1CB/PTPRF/PIK3CB/SLC27A2/PRKCZ/SLC27A6/GFPT1/SLC2A1/AKT1/TNF/PRKAB2/RPS6KB2/PPP1CC/MAPK9/RPS6KA1/CREB3L4	0.481838117762926
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	26/1231	183/9376	1.08213589733346	RAN/IMP4/POP5/GAR1/RRP7A/CSNK2A2/EMG1/UTP18/RPP25L/RPP30/WDR43/NHP2/RBM28/RPP38/SNORD3A/NVL/NXT2/XPO1/UTP6/TCOF1/REXO1/NXF1/GNL3/RCL1/NOP58/POP1	0.436213438984965
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	22/1231	154/9376	1.08808169896716	CALM1/TPM1/PPP1CB/GNAS/GNAI1/MYL4/MAPK3/TPM3/AKT1/TNNC1/PPP2R5A/CALM3/ADCY5/TNNT2/PPP2R1B/PPP1CC/KCNQ1/MYL3/PLCB3/ADRB1/ATP1A4/CREB3L4	0.428452424536781
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1231	52/9376	1.1717802911954	CGA/HSD3B1/GNAS/CYP19A1/CYP11A1/HSD17B1/CYP2J2/ADCY5	0.482884198721788
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	15/1231	103/9376	1.1092094989471	CALR/GNAS/CCL3L1/CCL3/PIK3CB/GNAI1/CCL2/MAPK3/AKT1/TNF/NOS2/CASP8/PPP2R1B/PLCB3/MAPK9	0.433249447318583
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1231	10/9376	1.52331437855402	SUOX/BPNT1	0.643657317832249
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1231	31/9376	1.22847933754357	ACOX1/CNDP2/ACOX3/ALDH3B2/EHHADH	0.495344386038322
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1231	60/9376	1.14248578391552	RAC3/PIK3CB/RAC1/MAPK3/PPP3R1/CDC42/AKT1/NRAS/PPP3CA	0.43042901746608
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/1231	68/9376	1.12008410187796	CCNA2/PIK3CB/JUP/MAPK3/AKT1/NRAS/RPS6KB2/BCL2A1/GRB2/BRAF	0.38634998851609
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	12/1231	83/9376	1.101191117027	AURKB/EZH2/CBX3/HDAC1/HCFC1/USP45/EP300/BCORL1/JARID2/EED/MTF2/RNF2	0.359975205224158
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/1231	83/9376	1.101191117027	CCL4/CASP3/GSDMD/DDX41/CASP8/TBK1/ZCCHC3/POLR3K/CCL4L2/POLR2F/IRF3/G3BP1	0.359975205224158
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/1231	77/9376	1.08808169896716	PIK3CB/MAPK3/BAK1/HDAC1/AKT1/CTBP1/NRAS/GRB2/CRKL/MDM2/BRAF	0.301704676583613
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1231	70/9376	1.08808169896716	LEP/ADIPOR2/SLC2A1/AKT1/RXRA/TNF/PRKAB2/ACSL4/MAPK9/TRAF2	0.287555910879339
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1231	26/9376	1.1717802911954	SLC19A1/SLC5A6/SLC46A1/SLC52A3	0.340975616671333
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/1231	116/9376	1.05056164038208	EZR/CLDN7/CTNNB1/CLDN4/F11R/CDH5/CLDN19/PIK3CB/GNAI1/CLDN6/RAC1/CLDN3/CDC42/CTNND1/VAV3/ACTN4	0.213016761117235
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	14/1231	101/9376	1.05576244058199	CALM1/CTNNB1/GNAS/WNT7A/GNAI1/MAPK3/DVL3/CALM3/ADCY5/NRAS/EP300/PLCB3/FZD6/CREB3L4	0.219035557045377
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	25/1231	184/9376	1.03486031151768	EFNA1/RAC3/BMP7/PIK3CB/GNAI1/SEMA6A/PRKCZ/LIMK2/RAC1/MAPK3/PPP3R1/CDC42/PARD6B/NRAS/SEMA4C/SEMA4B/SLIT2/ROBO1/PPP3CA/MET/RASA1/EPHB4/PAK6/SSH3/EPHB3	0.18565399016497
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1231	49/9376	1.08808169896716	B4GALT1/GALNT1/COLGALT1/GXYLT1/GALNT3/XXYLT1/GALNT6	0.240315539761687
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	21/1231	155/9376	1.0319226435366	CCNE1/CTNNB1/HSD3B1/GNAS/CYP11A1/WNT7A/GNAI1/MAPK3/ARNT/FH/DVL3/CDK2/ADCY5/CCNE2/ORAI1/ITPR3/PLCB3/ASH2L/FZD6/BRAF/CREB3L4	0.155791875936965
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	17/1231	125/9376	1.03585377741673	RAC3/PIK3CB/GNAI1/PRKCZ/RAC1/MAPK3/CERS5/AKT1/TNF/PPP2R5A/NRAS/PPP2R1B/SMPD2/PLD2/PLCB3/MAPK9/TRAF2	0.156878961008956
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/1231	42/9376	1.08808169896716	TFRC/NCOA4/SLC39A8/HMOX1/CP/ACSL4	0.222405513951897
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1231	27/9376	1.12838102115113	HMGCS1/HADH/ACAT2/EHHADH	0.259698384661316
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	14/1231	103/9376	1.0352621990173	COL3A1/COL4A1/COL1A1/COL9A3/COL4A2/COL27A1/COL21A1/DPP4/SLC6A19/COL1A2/KCNQ1/KCNN4/ATP1A4/SLC36A1	0.139890104640816
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/1231	73/9376	1.04336601270823	PIK3CB/MAPK3/BAK1/ERBB2/AKT1/RXRA/NRAS/GRB2/MET/BRAF	0.144600079811517
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	20/1231	150/9376	1.01554291903601	CCNE1/CTNNB1/CDH1/WNT7A/PIK3CB/JUP/MAPK3/BAK1/ERBB2/AKT1/RXRA/DVL3/CDK2/NRAS/RPS6KB2/CCNE2/GRB2/MET/FZD6/BRAF	0.0746003061014433
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1231	28/9376	1.08808169896716	B4GALT1/B3GNT2/ST3GAL4/ST3GAL6	0.18145730944869
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1231	51/9376	1.04541182841943	PLA2G2A/PLA2G10/GDPD3/PLA2G12A/LPCAT4/PAFAH1B3/PLD2	0.126415048736486
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/1231	82/9376	1.02173525390818	HLA-G/CALR/HSP90AB1/HSP90AA1/HSPA8/NFYC/RFXANK/HSPA2/TNF/HSPA4/NFYB	0.0768492140734496
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/1231	105/9376	1.01554291903601	UBA52/RPS27A/TOMM20/UBB/BNIP3/CSNK2A2/TOMM7/NRAS/TOMM40/TBK1/TFEB/BCL2L13/MAPK9/TRAF2	0.0622634332175429
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	14/1231	105/9376	1.01554291903601	CALM1/PIK3CB/MAPK3/PPP3R1/AKT1/TNF/CASP8/CALM3/NRAS/PPP3CA/ITPR3/MDM2/MAPK9/EGR2	0.0622634332175429
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1231	44/9376	1.0386234399232	B4GALT1/TUSC3/ALG3/STT3A/ALG12/MAN1A2	0.0998295341042438
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1231	75/9376	1.01554291903601	CGA/GPX3/GNAS/GSR/ADCY5/LRP2/ITPR3/PLCB3/ATP1A4/CREB3L4	0.0525372715550607
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1231	60/9376	1.01554291903601	GNAS/GNAI1/MAPK3/NRAS/PPP2R1B/ITPR3/PLCB3/BRAF	0.0469529182868738
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1231	29/9376	1.05056164038208	RASSF6/TEAD3/STK3/WWC1	0.106011542423708
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/1231	122/9376	0.998894674461653	PIK3CB/MAPK3/PPP3R1/CDC42/AKT1/TNF/PPP2R5A/NRAS/DLG1/PPP2R1B/MAP3K8/VAV3/GRB2/PPP3CA/MAPK9/PAK6	-0.00477721175782852
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/1231	99/9376	1.00015590511123	GNAS/PIK3CB/MAPK3/ERBB2/AKT1/ADCY5/NRAS/CARM1/RPS6KB2/GRB2/MDM2/MAPK9/BRAF	0.00060623819205878
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/1231	99/9376	1.00015590511123	CALM1/PPP1CB/GNAS/IL1RAP/PIK3CB/CYP2J2/CALM3/ADCY5/PPP1CC/MAP2K6/ITPR3/PLCB3/MAPK9	0.00060623819205878
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1231	37/9376	1.02926647199596	HBA2/HBA1/HBB/TNF/PLCB3	0.0693410106264933
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/1231	76/9376	1.00218051220659	CALM1/PIK3CB/MAPK3/BAK1/AKT1/CALM3/NRAS/GRB2/MDM2/BRAF	0.00741981307580165
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/1231	115/9376	0.99346589905697	GCM1/NACA/GATA3/MMP15/GNAS/GNAI1/MAPK3/RXRA/ADCY5/PLD2/ITPR3/PLCB3/BRAF/PTH1R/CREB3L4	-0.0274078480492372
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/1231	100/9376	0.990154346060114	CCL4/CCL3L1/CXCL14/CCR7/CCL3/CCL2/CXCL13/CCL20/TNF/CXCL1/IL2RB/CCL4L2/TNFRSF10B	-0.0384798452892061
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1231	30/9376	1.01554291903601	PLA2G2A/PLA2G10/PLA2G12A/CYP2J2	0.0331473980928984
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1231	38/9376	1.00218051220659	PIK3CB/MAPK3/HSD11B2/SFN/ATP1A4	0.00523591401720365
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1231	62/9376	0.982783470034852	NCSTN/TLE3/HDAC1/HEY1/CTBP1/DVL3/EP300/ADAM17	-0.0528740370585505
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1231	102/9376	0.970739554960896	CA2/PLA2G2A/GNAS/PLA2G10/RAC1/RAB8A/RAB11A/PLA2G12A/ADCY5/KCNQ1/ITPR3/PLCB3/ATP1A4	-0.11550920311633
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/1231	31/9376	0.982783470034852	SRP68/SEC11A/SEC11C/IMMP1L	-0.0373255260496819
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1231	63/9376	0.967183732415251	EZH2/COLGALT1/SMYD2/KMT2C/HADH/ACAT2/DHTKD1/EHHADH	-0.101597676960317
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1231	63/9376	0.967183732415251	PTGDS/PLA2G2A/PLA2G10/PLA2G12A/CYP2J2/PTGR1/LTC4S/PTGES3	-0.101597676960317
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1231	23/9376	0.99346589905697	CA2/CA4/ATP1A4	-0.0121967300202772
Organismal Systems	Immune system	hsa04611	Platelet activation	16/1231	126/9376	0.967183732415251	COL3A1/VAMP8/PPP1CB/GNAS/COL1A1/PIK3CB/GNAI1/PRKCZ/MAPK3/AKT1/ADCY5/COL1A2/PPP1CC/ORAI1/ITPR3/PLCB3	-0.144169273786244
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1231	48/9376	0.952071486596263	PIK3CB/AKT1/HK1/HK2/PLCB3/ATP1A4	-0.129416434039768
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	46/1231	362/9376	0.967851676981837	CCNE1/PGF/HSP90AB1/HSP90AA1/RPS6/FN1/FLT1/EFNA1/IGF2/COL4A1/YWHAE/COL1A1/COL9A3/COL4A2/PIK3CB/CCND3/FLT4/YWHAZ/RAC1/ERBB3/MAPK3/FGFR3/ERBB2/AKT1/RXRA/GNG12/PPP2R5A/CDK2/TSC1/NRAS/ITGB4/RPS6KB2/THEM4/COL1A2/ANGPT4/IL2RB/YWHAB/MLST8/IFNAR2/PPP2R1B/CDC37/CCNE2/GRB2/MDM2/MET/CREB3L4	-0.242506259017854
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1231	32/9376	0.952071486596263	ATG12/MLST8/ATG4C/ATG10	-0.105577567904791
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/1231	120/9376	0.952071486596263	CALM1/YWHAE/PIK3CB/ARHGDIB/RAC1/MAPK3/CDC42/AKT1/CALM3/NRAS/GRB2/CRKL/MAPK9/RPS6KA1/BRAF	-0.205419670899649
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1231	24/9376	0.952071486596263	EXTL2/B4GALT7/XYLT2	-0.0913937402132682
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/1231	73/9376	0.93902941143741	CDH1/PIK3CB/MAPK3/BAK1/AKT1/NRAS/MDM2/MET/BRAF	-0.2033009590165
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/1231	65/9376	0.937424232956321	HSD3B1/GNAS/CYP11A1/ADCY5/ORAI1/ITPR3/PLCB3/CREB3L4	-0.196803952887913
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1231	49/9376	0.932641456257564	GNAS/FOSB/GNAI1/ADCY5/GRIN2D/CREB3L4	-0.183776028242374
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/1231	169/9376	0.946437927503977	UBA52/RPS27A/HMGB1/VAMP8/PIK3CB/UBB/BNIP3/SNAP29/MAPK3/RAB8A/AKT1/ATG12/VPS33A/TSC1/NRAS/RPS6KB2/TBK1/MLST8/ATG4C/MAPK9/ATG10	-0.273156018623636
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/1231	33/9376	0.923220835487286	VAMP8/SNAP29/BET1/VTI1B	-0.171761687326777
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1231	98/9376	0.932641456257564	CALM1/HSD3B1/GNAS/CYP11A1/PRKD3/CALM3/ADCY5/ORAI1/ITPR3/PLCB3/ATP1A4/CREB3L4	-0.260583950311448
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/1231	90/9376	0.93091434244968	PPARG/PIK3CB/ADIPOR2/AKT1/ADCY5/TSC1/NRAS/SESN2/PRKAB2/RPS6KB2/CREB3L4	-0.256014127197379
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/1231	122/9376	0.9364637573078	GNAS/PIK3CB/GNAI1/MAPK3/AKT1/ADCY5/NRAS/EP300/MAP2K6/GRB2/CRKL/ITPR3/PLCB3/MAPK9/CREB3L4	-0.274603340922887
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1231	217/9376	0.94768406039075	MGST3/HSP90AB1/HSP90AA1/BIRC5/GNAS/KPNA2/KLF5/PIK3CB/GNAI1/CCND3/CDC6/GSTA3/MAPK3/GSTM4/ARNT/AKT1/RXRA/ADCY5/NRAS/RPS6KB2/CDC25A/PAQR7/GRB2/ADRB1/RPS6KA1/PTGES3/CREB3L4	-0.303116088150207
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1231	42/9376	0.906734749139298	HADH/KMO/ACAT2/DHTKD1/EHHADH	-0.23549393681951
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/1231	34/9376	0.896067281502365	POLR2D/POLR3K/POLR2F/POLR2I	-0.236015722137836
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1231	59/9376	0.903661072023572	CGA/GNAS/PIK3CB/GNAI1/AKT1/ADCY5/ADRB1	-0.288575121881983
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/1231	140/9376	0.924869444122084	CALM1/RPS6/CDH1/GNAI1/MYL4/MAPK3/AKT1/NOS2/GNG12/CALM3/ADCY5/NRAS/PRKAB2/RPS6KB2/MYL3/ITPR3/PLCB3	-0.348183172583562
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1231	17/9376	0.896067281502365	CA2/CA4	-0.166736677942805
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1231	17/9376	0.896067281502365	TFRC/MYH10	-0.166736677942805
NA	NA	hsa04517	IgSF CAM signaling	37/1231	299/9376	0.942518929874562	EZR/TUBA1C/TUBA1B/CTNNB1/PTPRF/TUBB4B/ARPC3/IL1RAP/F11R/CDH1/PIK3CB/ARPC1B/RAC1/CNTNAP2/MAPK3/TUBB/EPB41L3/ICAM3/CDC42/AKT1/PARD6B/ARPC5L/TRIO/VAV3/SLIT2/ROBO1/GRB2/CD2AP/ACTN4/MAPK9/PTPRS/SSX2IP/ARF6/RASA1/MYH10/RAPGEF2/PAK6	-0.392697730684301
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1231	43/9376	0.885647894508152	PLA2G2A/PLA2G10/PLA2G12A/ACAT2/GOT2	-0.292170847706762
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	16/1231	133/9376	0.916279325446028	CALM1/PPP1CB/GNAS/GNAI1/AKT1/GNG12/PPP2R5A/CALM3/ADCY5/PPP2R1B/PPP1CC/PPP3CA/ITPR3/PLCB3/MAPK9/CREB3L4	-0.378025575460534
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/1231	134/9376	0.909441420032251	CALM1/PPP1CB/PLA2G2A/GNAS/PLA2G10/ADM/MAPK3/PLA2G12A/CALM3/ADCY5/ACTG2/PPP1CC/ITPR3/PLCB3/MYH10/BRAF	-0.410457448595397
NA	NA	hsa04519	Cadherin signaling	50/1231	404/9376	0.942645036233924	KRT8/KRT18/KRT7/KRT19/DSP/DSC2/CTNNB1/KRT23/PPP1CB/DSG2/YWHAE/RAC3/ARPC3/PKP3/CDH5/CDH1/PKP2/WNT7A/ARPC1B/NCSTN/JUP/FLT4/YWHAZ/RAC1/MAPK3/DSC3/CDC42/ERBB2/TEAD3/TAOK3/MYO1B/DVL3/NRAS/EP300/ARPC5L/YWHAB/CTNND1/STK3/FAT2/PPP1CC/PCDH10/VAV3/CYFIP2/ACTN4/MAPK9/MYO1G/MET/KRT15/FZD6/WWC1	-0.458127308267618
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1231	44/9376	0.86551953326933	GNAS/ARHGDIB/RAB11A/DCTN5/CREB3L4	-0.347590022187051
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1231	18/9376	0.846285765863345	PRDX1/HCFC1	-0.253762788560141
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/1231	86/9376	0.885647894508152	GNAS/SLC2A1/ADCY5/ABCC8/KCNN4/ITPR3/PLCB3/ATP1A4/CREB3L4/TRPM4	-0.414147128363353
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/1231	78/9376	0.878835218396551	CALM1/GNAI1/CASP3/MAPK3/TNF/NOS2/CALM3/MAPK9/IRF3	-0.417732297515467
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1231	53/9376	0.862253421823031	GNAS/CLTA/RAB11A/PLCB3/ATP1A4/PTH1R	-0.390939931194657
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/1231	95/9376	0.881918850741802	FLT1/CCL3L1/CCL3/ATP6V1C2/ATP6V1B1/CCL2/CCL20/TNF/CXCL1/ATP6V1A/ATP6V1E1	-0.449690909137408
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/1231	144/9376	0.899178626229804	CTNNB1/DUSP9/ID3/ID1/WNT7A/PIK3CB/LIFR/MAPK3/DLX5/FGFR3/AKT1/DVL3/NRAS/TCF3/JARID2/GRB2/FZD6	-0.473974611459192
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/1231	144/9376	0.899178626229804	CTNNB1/SCD/CASP3/ADIPOR2/ACOX1/AKT1/TNF/CASP8/CXCL1/PRKAB2/TBK1/TRA2B/ACOX3/MAP2K6/MAPK9/TRA2A/IRF3	-0.473974611459192
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1231	45/9376	0.846285765863345	ABCA7/ABCG2/ABCC8/ABCD1/ABCB10	-0.401814281031366
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/1231	104/9376	0.878835218396551	PLA2G2A/PLA2G10/LYPLA1/LYPLA2/CDS2/PLA2G12A/DGKZ/LPCAT4/PHOSPHO1/PLD2/PCYT2/PTDSS1	-0.483031532225851
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/1231	71/9376	0.858205283692406	CGA/PIK3CB/MAPK3/AKT1/NRAS/ELF5/GRB2/MAPK9	-0.466229934355545
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	27/1231	226/9376	0.909944429667225	CGA/CALM1/PPP1CB/GNAS/RAC3/PIK3CB/GNAI1/RAC1/MAPK3/ACOX1/AKT1/CALM3/ADCY5/EP300/TIAM1/PPP1CC/ORAI1/PLD2/VAV3/ACOX3/GRIN2D/ADRB1/ATP1A4/MAPK9/BRAF/HCAR3/CREB3L4	-0.532749896351168
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1231	37/9376	0.823413177596768	MIF/GOT1/ALDH3B2/GOT2	-0.418386908078684
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/1231	72/9376	0.846285765863345	ISG15/ATG12/TNF/CASP8/TBK1/MAPK9/IRF3/TRAF2	-0.508996274121353
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1231	89/9376	0.85579459469327	FN1/COL4A1/HMMR/SDC4/COL1A1/COL9A3/COL4A2/SDC1/ITGB4/COL1A2	-0.53138334755817
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1231	38/9376	0.801744409765274	PNP/QPRT/NMRK1/NADK2	-0.47605751564263
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/1231	90/9376	0.846285765863345	PIK3CB/CSNK2A2/MAPK3/PPP3R1/AKT1/NRAS/RPS6KB2/CD274/MAP2K6/PPP3CA	-0.569626415752727
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/1231	157/9376	0.873237541846254	CALR/PPARG/ARG2/RAC1/CASP3/MAPK3/SLC2A1/ODC1/ARNT/RXRA/VPS33A/ANO6/ADAM17/SLC16A1/DUSP5/ELMO1/CRKL/TMEM30B	-0.622683978267483
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/1231	116/9376	0.853581332810443	GNAS/GNAI1/SLC38A1/MAPK3/PPP3R1/GNG12/ADCY5/PLD2/GRIN2D/PPP3CA/ITPR3/PLCB3/SHANK2	-0.616863496044204
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/1231	91/9376	0.836985922282429	RAC3/PIK3CB/RAC1/MAPK3/PPP3R1/AKT1/NRAS/VAV3/GRB2/PPP3CA	-0.607468795097852
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	15/1231	133/9376	0.859011867605651	HLA-G/RAC3/PIK3CB/RAC1/CASP3/MAPK3/PPP3R1/TNF/NRAS/IFNAR2/VAV3/GRB2/PPP3CA/TNFRSF10B/BRAF	-0.636606431630226
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/1231	142/9376	0.858205283692406	PPARG/FOSB/PIK3CB/RAC1/MAPK3/PPP3R1/FHL2/AKT1/TNF/IFNAR2/MAP2K6/GRB2/PPP3CA/ITPR3/MAPK9/TRAF2	-0.661878700372244
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1231	21/9376	0.725387799311439	BCAT2/PPCDC	-0.489752543665294
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/1231	168/9376	0.861398011682333	HSP90AB1/HSP90AA1/HMGB1/SLC25A5/VDAC1/CAPN1/AIFM1/CHMP4C/CHMP2B/TNFAIP3/TNF/PPIA/CASP8/DNM1L/IFNAR2/MAPK9/TRAF2/PARP1/TNFRSF10B	-0.704710214376694
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1231	22/9376	0.692415626615464	CNDP2/ALDH3B2	-0.561495196922288
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/1231	148/9376	0.823413177596768	CTNNB1/WNT7A/PIK3CB/FLT4/MAPK3/BAK1/ERBB2/AKT1/HEY1/DVL3/NRAS/RPS6KB2/GRB2/BRCA2/FZD6/BRAF	-0.841791385020585
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/1231	97/9376	0.785213597192794	CALM1/GNAS/GNAI1/MAPK3/GNG12/CALM3/ADCY5/GRIN2D/ITPR3/PLCB3	-0.826630042066129
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/1231	191/9376	0.837424134807184	CALM1/PPP1CB/GNAS/FOSB/GNAI1/MAPK3/SLC29A1/HDAC1/HDAC8/GNG12/CALM3/ADCY5/NRAS/HAT1/PKIA/SLC29A2/PPP1CC/GRIN2D/GRB2/BRAF/CREB3L4	-0.882474769626567
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/1231	166/9376	0.825893337770252	CALM1/PPP1CB/SLC25A5/GNAI1/VDAC1/MAPK3/PPP3R1/PPIF/AKT1/CALM3/ADCY5/PPP1CC/PPP3CA/ITPR3/PLCB3/ADRB1/ATP1A4/CREB3L4	-0.879850204015806
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/1231	115/9376	0.794772719245576	PIK3CB/GNAI1/MAPK3/AKT1/GNG12/ADCY5/NRAS/KCNQ1/ITPR3/PLCB3/SLC18A3/CREB3L4	-0.860843469594038
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/1231	115/9376	0.794772719245576	GNAS/GNAI1/CASP3/MAPK3/GNG12/CYP2J2/ADCY5/NRAS/ITPR3/PLCB3/SLC6A4/BRAF	-0.860843469594038
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1231	34/9376	0.672050461126774	RBX1/CUL1/PRKAB2	-0.744724552198606
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	28/1231	250/9376	0.853056051990252	HLA-G/HSPA8/FOLR1/ARPC3/CLTA/ARPC1B/PRKCZ/TFRC/RAB8A/CHMP4C/CHMP2B/FGFR3/ASAP1/SH3GL1/RAB11A/CDC42/PARD6B/VPS25/RAB11FIP4/NEDD4/IL2RB/ARPC5L/EPN3/PLD2/RAB11FIP1/MDM2/ARF6/AGAP6	-0.915483658537959
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/1231	98/9376	0.77720121354797	CALM1/PIK3CB/CDS2/PIK3C2A/DGKZ/CALM3/PLCD4/INPP5A/ITPR3/PLCB3	-0.861921660899718
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/1231	160/9376	0.809260763606824	HLA-G/CLDN7/CLDN4/PTPRF/SDC4/F11R/CDH5/CLDN19/CDH1/CLDN6/CNTNAP2/CD276/ICAM3/CLDN3/SDC1/CD274/PTPRS	-0.946014772702144
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/1231	109/9376	0.76864486991258	HSP90AB1/HSP90AA1/GATA3/EBI3/IL1RAP/MAPK3/PPP3R1/RXRA/IL2RB/PPP3CA/MAPK9	-0.944478164407054
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1231	36/9376	0.634714324397509	AKR1B1/DCXR/UGP2	-0.853649469226339
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/1231	36/9376	0.634714324397509	GALNT1/GALNT3/GALNT6	-0.853649469226339
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1231	93/9376	0.737087602526139	CALM1/GNAS/CALM3/ADCY5/KCNN4/ITPR3/PLCB3/ADRB1/ATP1A4	-0.990552469135112
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1231	66/9376	0.692415626615464	HSD3B1/CYP19A1/CYP11A1/HSD17B1/HSD17B8/HSD11B2	-0.974833657228002
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/1231	112/9376	0.748056168039921	HSPA8/GNAI1/CASP3/MAPK3/PPIF/AKT1/TNF/NOS2/CASP8/MAP2K6/MAPK9	-1.04275573960192
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	27/1231	250/9376	0.822589764419171	VAMP8/CTSV/GM2A/ATP6V1C2/AP1M2/ATP6V1B1/CLTA/NAGA/SNAP29/AP1S1/TELO2/SLC29A1/GAA/AP1G1/AP5B1/LAPTM4B/AP1B1/SLC38A9/VPS33A/ATP6V1A/ROGDI/MLST8/SLC29A2/TTI1/TFEB/ATP6V1E1/SLC36A1	-1.10529337023695
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1231	38/9376	0.601308307323956	RFXANK/ORAI1/DCLRE1C	-0.957350945302463
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1231	16/9376	0.476035743298132	NAGA	-0.815441573075653
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/1231	201/9376	0.79576124252822	FLT1/PPARG/SPINT1/MYCN/CCNA2/JUP/BAK1/HDAC1/NFKBIZ/RXRA/ETV4/LMO2/IL2RB/FLI1/BCL2A1/TCF3/CCNT1/TAF15/MDM2/MET/ETV5	-1.13789521792387
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/1231	105/9376	0.725387799311439	CCL4/CSNK2A2/TNFAIP3/TNF/CXCL1/BCL2A1/CCL4L2/TRAF2/PPP1R13L/PARP1	-1.10006996618053
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/1231	105/9376	0.725387799311439	TPM1/GNAS/TPM3/TNF/TNNC1/ADCY5/ITGB4/TNNT2/MYL3/ADRB1	-1.10006996618053
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/1231	78/9376	0.683538503197317	TPI1/ISYNA1/PIK3CB/PIK3C2A/PLCD4/INPP5A/PLCB3	-1.09104466153558
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1231	79/9376	0.674886117080896	MGST3/GSTP1/GSTA3/GSTM4/AKR7A2/ALDH3B2/CYP2S1	-1.12809783441206
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1231	79/9376	0.674886117080896	ATP6V1C2/ATP6V1B1/CLTA/ATP6V1A/ATP6V1E1/SLC18A3/SLC6A4	-1.12809783441206
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1231	17/9376	0.448033640751183	PSTK	-0.885505915824062
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1231	29/9376	0.525280820191042	CALM1/CALM3	-0.995333855653509
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/1231	70/9376	0.652849019380295	HLA-G/RAC3/RAC1/CASP3/EIF4G1/CASP8	-1.1333264187147
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1231	30/9376	0.507771459518007	PIGF/PIGS	-1.04974460371552
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/1231	154/9376	0.741873885659426	CALM1/PPP1CB/GNAS/GNAI1/MAPK3/PPP3R1/CALM3/ADCY5/NRAS/PRKAB2/EEF2K/PPP1CC/PPP3CA/ITPR3/PLCB3	-1.25559294180638
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/1231	181/9376	0.757449138507524	CALM1/HSPD1/CASP3/MAPK3/NFYC/RFXANK/PPP3R1/AKT1/HSPA9/TNF/APAF1/NOS2/CASP8/CALM3/NFYB/EP300/PPP3CA/MAPK9	-1.28095939257126
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/1231	52/9376	0.5858901455977	LIPG/VDAC1/PLTP/LRP2	-1.16408642594736
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1231	63/9376	0.604489832759532	CTNNB1/WNT7A/BAK1/DVL3/FZD6	-1.22448155025689
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1231	44/9376	0.519311719961598	HLA-G/HSPD1/TNF	-1.24242913476964
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/1231	55/9376	0.553932501292371	GM2A/CERS5/SMPD4/SMPD2	-1.28979233598678
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/1231	86/9376	0.619953526155706	DSP/DSC2/CTNNB1/DSG2/PKP2/JUP/ITGB4	-1.37640802598473
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	25/1231	254/9376	0.749662587871073	CALM1/FLT1/SLC25A5/GNAS/FLT4/VDAC1/ERBB3/FGFR3/PPP3R1/PPIF/ERBB2/TNNC1/NOS2/PHKG2/CALM3/PLCD4/TFEB/ORAI1/CYSLTR1/GRIN2D/PPP3CA/ITPR3/PLCB3/ADRB1/MET	-1.57241328013805
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/1231	99/9376	0.615480556991524	TPM1/TPM3/TNF/TNNC1/ITGB4/PRKAB2/TNNT2/MYL3	-1.49520673253015
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1231	90/9376	0.592400036104342	CA2/GNAS/ABCG2/SLC2A1/RXRA/ADCY5/ATP1A4	-1.51046328141877
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1231	23/9376	0.331155299685657	B4GALT1	-1.24848365618371
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1231	23/9376	0.331155299685657	LNPEP	-1.24848365618371
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/1231	149/9376	0.66453311816115	GNAS/RALB/PIK3CB/MAPK3/AKT1/DGKZ/ADCY5/TSC1/NRAS/PLD2/GRB2/PLCB3/ARF6	-1.60465489839159
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	32/1231	323/9376	0.754582973896729	CCNE1/EZR/TPM1/EFNA1/STMN1/IGF2BP1/PIK3CB/HNRNPK/EZH2/TRIM71/CDCA5/CASP3/ERBB3/MAPK3/BAK1/FGFR3/HDAC1/ERBB2/HMOX1/KIF23/NRAS/EP300/DNMT1/CCNE2/CDC25C/CDC25A/GRB2/SLC7A1/CRKL/MDM2/MET/DNMT3B	-1.7449332186002
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1231	73/9376	0.521683006354117	MGST3/GSTP1/GSTA3/GSTM4/ALDH3B2	-1.59490511432857
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1231	39/9376	0.390593430398467	HLA-G/TNF	-1.48253473075676
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/1231	155/9376	0.638809255522654	HLA-G/TUBA1C/TUBA1B/CALR/TUBB4B/ATP6V1C2/ATP6V1B1/RAC1/TFRC/TUBB/ATP6V1A/ATP6V1E1/COLEC12	-1.76271691248528
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/1231	65/9376	0.46871211647816	AKR1B1/LIPG/DGKZ/GLYCTK	-1.67092727006553
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/1231	168/9376	0.634714324397509	LEP/PIK3CB/CCND3/LIFR/PTPN2/AKT1/CSF2RB/IL11RA/EP300/IL2RB/IFNAR2/CNTFR/CSF2RA/GRB2	-1.85726445837542
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/1231	100/9376	0.533160032493907	GYPA/CD9/TFRC/CD33/TNF/IL11RA/CSF2RA	-1.82455424841592
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1231	45/9376	0.338514306345338	HLA-G/TNF	-1.72914629475424
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1231	70/9376	0.435232679586863	MGST3/GSTP1/GSTA3/GSTM4	-1.84376758351171
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1231	93/9376	0.491391735017426	GATA3/MAPK3/PPP3R1/IL2RB/PPP3CA/MAPK9	-1.9162396963464
Human Diseases	Immune disease	hsa05310	Asthma	1/1231	32/9376	0.238017871649066	TNF	-1.67850438465583
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/1231	298/9376	0.66453311816115	LEP/CCL4/CCL3L1/EBI3/GDF15/CXCL14/IL1RAP/CCR7/CCL3/BMP7/CCL2/CXCL13/LIFR/CCL20/CSF2RB/TNF/CXCL1/IL11RA/IL2RB/IFNAR2/CNTFR/CSF2RA/CCL4L2/INHA/CXCR6/TNFRSF10B	-2.28787248399598
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1231	54/9376	0.282095255287782	HLA-G/CGA	-2.05673469675836
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/1231	56/9376	0.272020424741789	CUL1/LRP2	-2.12409713061364
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1231	41/9376	0.185770046165125	GRIN2D	-2.03119193136491
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/1231	195/9376	0.546830802557854	HMGB1/SLC25A5/PIK3CB/VDAC1/CASP4/RAC1/MAPK3/GSDMD/PPIF/HDAC1/HDAC8/AKT1/HAT1/PLCB3	-2.48600395316029
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/1231	89/9376	0.342317837877308	GNAI1/SLC38A1/GNG12/ADCY5	-2.42349687374542
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/1231	91/9376	0.334794368912972	GNAS/GNAI1/GNG12/ADCY5	-2.47887586683679
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/1231	78/9376	0.29294507279885	MAPK3/TNF/NOS2	-2.43766938957582
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/1231	66/9376	0.230805208871821	GATA3/TNF	-2.43782531311752
NA	NA	hsa04081	Hormone signaling	15/1231	219/9376	0.521683006354117	CGA/LEP/DIO2/IGF2/GNAS/GAST/PIK3CB/GNAI1/ADIPOR2/GNG12/ADCY5/THRB/PLCB3/ADRB1/PTH1R	-2.78439202652049
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/1231	99/9376	0.307740278495762	KRT18/KRT19/KRT23/KRT15	-2.69185710910791
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/1231	88/9376	0.259655859980799	TFPI/SERPINE2/C7	-2.71258275385716
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/1231	143/9376	0.319576443053291	SNRPB/SNRPD1/TNF/SNRPD3/ACTN4/C7	-3.18746233957682
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1231	86/9376	0.17712957890163	ITPR3/PLCB3	-2.98017618868703
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/1231	68/9376	0.112008410187796	CYP2S1	-2.85696053983068
NA	NA	hsa04082	Neuroactive ligand signaling	9/1231	199/9376	0.344468075552417	GNAS/GNAI1/GNG12/ADCY5/GRIN2D/PLCB3/ADRB1/SLC18A3/SLC6A4	-3.63361692189604
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/1231	370/9376	0.26760928271895	CGA/LEP/KISS1/TMEM97/KISS1R/ADM/RLN2/THRB/CYSLTR1/CHRNA5/GRIN2D/ADRB1/PTH1R	-5.58787705608128
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1231	449/9376	0.0339268235758134	CALM1/CALM3	-8.15548038079569