category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	129/1959	222/9376	2.78112109046259	RPL38/RPL22/RPL35A/RPS5/RPS25/RPL36/RPSA/RPL5/RPL35/UBA52/RPL24/RPL37A/RPL26/RPL12/RPL37/RPS3/RPS19/RPL18/RPL14/RPL7A/RPL23A/RPL19/RPL39/RPLP2/RPS13/RPL6/RPL21/RPL32/RPL29/RPS3A/RPS15/RPS7/RPS27A/RPS18/RPL8/RPL11/RPS23/RPS14/RPS4X/RPS24/RPS2/RPL18A/RPS6/RPL13/RPS29/RPL28/RPL7/RPS8/RPS27/RPL34/RPL41/RPL30/RPS26/FAU/RPS21/RPL27/RPL3/RPL23/RPL27A/RPS15A/RPL10A/RPL31/RPS9/MRPS11/RPL15/RPS28/MRPL15/RPL36A/MRPS35/RPLP0/MRPL33/MRPL55/RPS16/RPL13A/MRPS18B/MRPL48/RPL10/RPL9/RPL4/MRPL46/MRPL34/RPL22L1/RPS11/MRPS34/MRPL51/RPL36AL/MRPL49/MRPL17/MRPL18/MRPL36/MRPL54/MRPS18A/RPS12/MRPS28/MRPL14/MRPL19/MRPL1/MRPL52/MRPS23/MRPL41/MRPS15/RSL24D1/MRPL21/MRPL9/MRPL45/MRPS2/MRPL12/MRPL4/MRPS25/DAP3/MRPS26/MRPL47/MRPS12/RPL26L1/MRPS14/MRPL10/MRPL44/MRPL53/RPS10/MRPL32/MRPS22/MRPL11/RPS17/MRPS5/MRPS6/MRPL42/MRPL16/MRPS30/MRPL38	13.8023550859107
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	120/1959	268/9376	2.14303673058902	CALM1/TUBB/MT-CO3/UBA52/MT-CYB/MT-CO1/MT-ATP6/RPS27A/TUBA1B/MT-ND1/MT-CO2/TUBA1C/MT-ND3/NDUFA4/MT-ND4/UQCRH/COX6C/HSPA5/CALM3/COX7C/COX5B/PSMA7/MT-ND5/UBE2J2/SDHA/NDUFA8/UQCRC2/SDHB/PSMC5/COX5A/CASP3/PSMD13/SLC39A3/PPIF/NDUFA5/SDHC/MT-ND2/PSMD2/NDUFB6/NDUFB2/COX6B1/PSMC2/NDUFA10/PSMC6/EIF2AK3/UQCRC1/PSMC3/SDHD/NDUFS5/SLC25A5/HTRA2/NDUFS6/SLC25A4/PSMC1/TUBA1A/TP53/PSMD12/NDUFB5/PSMB7/UBA1/GNAI3/PSMC4/EIF2S1/PSMD6/KLC2/KEAP1/NDUFA9/CYC1/NDUFV1/PSMD7/ADRM1/PSMB1/PSMA4/MT-ND4L/SLC25A6/COX8C/TXN2/UQCRFS1/SNCA/UQCRB/PSMD3/PSMA6/COX7A1/NDUFC1/UQCR10/COX7B/NDUFS8/MCU/TRAP1/VDAC3/PSMD14/VDAC1/NDUFA2/TUBB4B/NDUFA4L2/NDUFB7/UQCRQ/PLCG1/TUBB6/PSMD4/NDUFS7/COX8A/MT-ND6/NDUFS3/NDUFA3/GNAI1/NDUFS2/CYCS/PSMB4/PSMB5/CAMK2D/ADCY5/PSMD11/PARK7/NDUFA1/NDUFB4/PSMB2/CASP9/NDUFB9/PSMA1	9.75674128297317
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	132/1959	308/9376	2.05119229927806	TUBB/MT-CO3/MT-CYB/MT-CO1/MT-ATP6/TUBA1B/MT-ND1/MT-CO2/TUBA1C/MT-ND3/NDUFA4/MT-ND4/UQCRH/COX6C/COX7C/COX5B/PSMA7/MT-ND5/REST/POLR2B/SDHA/NRBF2/NDUFA8/UQCRC2/TBPL1/SDHB/PSMC5/COX5A/CASP3/PSMD13/PPIF/NDUFA5/HDAC2/CREB1/SDHC/MT-ND2/PSMD2/NDUFB6/ACTR1A/NDUFB2/HTT/COX6B1/PSMC2/NDUFA10/PSMC6/UQCRC1/PSMC3/SDHD/NDUFS5/SLC25A5/ACTR1B/POLR2E/SIN3A/NDUFS6/SLC25A4/PSMC1/TUBA1A/TP53/PSMD12/DCTN3/NDUFB5/PSMB7/PSMC4/PSMD6/POLR2J3/GPX1/DNAH14/POLR2D/KLC2/CREB3L4/DCTN5/NDUFA9/AP2A1/CYC1/NDUFV1/TAF4/PSMD7/ADRM1/PSMB1/PSMA4/MT-ND4L/POLR2H/SLC1A2/SLC25A6/COX8C/UQCRFS1/UQCRB/PSMD3/PSMA6/TRAF2/COX7A1/NDUFC1/AP2S1/UQCR10/TFAM/COX7B/NRF1/NDUFS8/AP2M1/CREB3L1/VDAC3/PSMD14/PIK3R4/TGM2/VDAC1/NDUFA2/TUBB4B/ATG2A/NDUFA4L2/NDUFB7/UQCRQ/TUBB6/PSMD4/NDUFS7/COX8A/MT-ND6/NDUFS3/NDUFA3/POLR2G/NDUFS2/CYCS/PLCB1/PSMB4/PSMB5/PSMD11/NDUFA1/NDUFB4/AMBRA1/PSMB2/CASP9/NDUFB9/PSMA1	9.6402986869801
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	82/1959	158/9376	2.48393329068693	CCNB1/PTTG1/CCNE1/CDC20/CDK1/CCNB2/MAD2L1/CCNA2/CDT1/AURKB/CDK4/CHEK1/CUL1/ORC6/ATM/ATRX/CDC6/STAG2/SMC3/HDAC2/PKMYT1/E2F4/CDC45/PPP2R5C/NDC80/PLK1/PDS5B/ANAPC15/CDCA5/TP53/MCM6/ORC2/CDC23/PPP2R1A/CCND2/ORC4/BUB1B/SFN/ORC3/CDKN1B/MCM4/BUB1/MCM5/PRKDC/MCM7/ZBTB17/ATR/MAD2L1BP/MAD1L1/CCNE2/TTK/YWHAH/ANAPC1/PPP2R5D/TFDP1/ANAPC10/TICRR/CCNH/ESCO2/E2F1/ORC5/YWHAE/ORC1/PPP2R1B/BUB3/CDK7/CDC25A/ABL1/ESPL1/ANAPC7/GADD45G/CDC25C/CDKN2C/RBL1/CCND1/SKP2/TRIP13/RAD21/ANAPC4/E2F2/ANAPC2/MCM2	9.6674800875299
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	147/1959	368/9376	1.91184499633797	TUBB/MT-CO3/MT-CYB/MT-CO1/MT-ATP6/ACTB/TUBA1B/MT-ND1/MT-CO2/TUBA1C/MT-ND3/ACTG1/PFN1/NDUFA4/MT-ND4/UQCRH/COX6C/HSPA5/COX7C/HNRNPA1/COX5B/HNRNPA2B1/PSMA7/MT-ND5/RANBP2/HNRNPA3/SDHA/TARDBP/NRBF2/NDUFA8/UQCRC2/SDHB/PSMC5/COX5A/CASP3/TANK/PSMD13/NDUFA5/TPR/SDHC/MT-ND2/PSMD2/NDUFB6/NUP62/ACTR1A/NDUFB2/COX6B1/PSMC2/NDUFA10/PSMC6/EIF2AK3/UQCRC1/PSMC3/SDHD/NDUFS5/NUP98/ACTR1B/NDUFS6/PSMC1/NUP54/TUBA1A/TP53/PSMD12/DCTN3/NDUFB5/PSMB7/PSMC4/C9orf72/EIF2S1/PSMD6/NUP133/NUP155/GPX1/DNAH14/KLC2/NCBP1/DCTN5/TOMM40/NDUFA9/CYC1/NDUFV1/GLE1/PSMD7/ADRM1/PSMB1/PSMA4/MT-ND4L/WDR41/SLC1A2/SRSF3/COX8C/UQCRFS1/SIGMAR1/UQCRB/RAE1/PSMD3/PSMA6/TRAF2/COX7A1/NDUFC1/UQCR10/COX7B/NDUFS8/MCU/FIG4/VCP/PSMD14/PIK3R4/NUP88/SEH1L/NUP188/VDAC1/NDUFA2/TUBB4B/ATG2A/NDUFA4L2/NDUFB7/UQCRQ/TUBB6/PSMD4/NUP43/NDUFS7/COX8A/MT-ND6/NDUFS3/NDUFA3/NDUFS2/NUP85/CYCS/CAT/NUP160/BCL2/PSMB4/PSMB5/NUP107/PSMD11/NDUFA1/NDUFB4/AMBRA1/PSMB2/NUP35/CASP1/HNRNPA1L2/CHCHD10/CASP9/NDUFB9/PSMA1	9.17105834913989
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	114/1959	275/9376	1.9840623694835	CYBA/TUBB/MT-CO3/MT-CYB/MT-CO1/MT-ATP6/TUBA1B/MT-ND1/MT-CO2/TUBA1C/MT-ND3/NDUFA4/MT-ND4/UQCRH/COX6C/HSPA5/COX7C/COX5B/PSMA7/MT-ND5/SDHA/NDUFA8/UQCRC2/SDHB/PSMC5/COX5A/CASP3/PSMD13/PPIF/NDUFA5/CREB1/SDHC/MT-ND2/PSMD2/NDUFB6/NDUFB2/COX6B1/PSMC2/NDUFA10/PSMC6/EIF2AK3/UQCRC1/PSMC3/SDHD/NDUFS5/SLC25A5/NDUFS6/STIP1/C1QA/SLC25A4/PSMC1/TUBA1A/C1QB/PSMD12/NDUFB5/PSMB7/PSMC4/CSNK2B/EIF2S1/PSMD6/KLC2/CREB3L4/NDUFA9/CYC1/NDUFV1/PSMD7/ADRM1/PSMB1/PSMA4/MT-ND4L/SLC25A6/COX8C/UQCRFS1/UQCRB/PSMD3/PSMA6/COX7A1/NDUFC1/UQCR10/COX7B/NDUFS8/C1QC/MCU/CREB3L1/VDAC3/PSMD14/VDAC1/NDUFA2/TUBB4B/NDUFA4L2/NDUFB7/UQCRQ/TUBB6/PSMD4/NDUFS7/FYN/COX8A/MT-ND6/NDUFS3/NDUFA3/NDUFS2/CYCS/IL1B/PSMB4/PSMB5/RAC2/PSMD11/NDUFA1/CAV1/NDUFB4/PSMB2/CASP9/NDUFB9/PSMA1	8.51202971673363
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	101/1959	238/9376	2.03108257085376	RPL38/RPL22/RPL35A/RPS5/RPS25/RPL36/RPSA/RPL5/RPL35/UBA52/RPL24/RPL37A/RPL26/RPL12/RPL37/RPS3/RPS19/RPL18/RPL14/RPL7A/RPL23A/RPL19/RPL39/RPLP2/RPS13/RPL6/RPL21/RPL32/RPL29/RPS3A/RPS15/RPS7/RPS27A/RPS18/RPL8/RPL11/RPS23/RPS14/RPS4X/RPS24/RPS2/RPL18A/RPS6/RPL13/RPS29/RPL28/RPL7/CFD/RPS8/RPS27/RPL34/RPL41/RPL30/RPS26/FAU/RPS21/RPL27/RPL3/RPL23/RPL27A/RPS15A/C1R/RPL10A/RPL31/RPS9/STAT2/RPL15/RPS28/RPL36A/RPLP0/RPS16/RPL13A/RPL10/RPL9/RPL4/RPL22L1/RPS11/IRAK1/RPL36AL/C1QA/C1QB/RPS12/ADAM17/C1S/OAS1/RSL24D1/MAVS/IRF9/C1QC/TYK2/RPL26L1/MMP3/PLCG1/RPS10/PRKCA/IKBKE/RPS17/IL1B/IL6R/FCGR2A/CASP1	8.28028078660031
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	67/1959	138/9376	2.32369369169422	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-ND1/MT-CO2/MT-ND3/NDUFA4/MT-ND4/UQCRH/COX6C/COX7C/COX5B/MT-ND5/SDHA/NDUFA8/UQCRC2/SDHB/ATP6V1A/COX5A/NDUFA5/SDHC/COX17/MT-ND2/NDUFB6/NDUFB2/COX6B1/NDUFA10/UQCRC1/SDHD/NDUFS5/COX11/NDUFS6/NDUFB5/ATP6V1B1/NDUFA9/COX15/CYC1/NDUFV1/TCIRG1/MT-ND4L/COX10/COX8C/UQCRFS1/UQCRB/COX7A1/NDUFC1/UQCR10/COX7B/NDUFS8/ATP6V1C2/NDUFA2/NDUFA4L2/NDUFB7/UQCRQ/NDUFS7/COX8A/MT-ND6/NDUFS3/NDUFA3/NDUFS2/CYCS/NDUFA1/ATP6V0E2/NDUFB4/PPA1/NDUFB9	8.05057277176716
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	88/1959	205/9376	2.0545275713094	COL1A1/COL3A1/COL1A2/CYBA/MMP2/MT-CO3/MT-CYB/MT-CO1/MT-ATP6/GAPDH/MT-ND1/MT-CO2/MT-ND3/NDUFA4/MT-ND4/UQCRH/COX6C/COX7C/COX5B/MT-ND5/SDHA/NDUFA8/UQCRC2/SDHB/PPP1CC/COX5A/PPIF/NDUFA5/AKT2/SDHC/MT-ND2/NDUFB6/NDUFB2/PRKCZ/COX6B1/NDUFA10/CPT2/UQCRC1/SDHD/NDUFS5/SLC25A5/INSR/PARP1/NDUFS6/SLC25A4/PTEN/NDUFB5/AKT1/REN/PDHA1/PDHB/NDUFA9/CYC1/NDUFV1/MT-ND4L/SLC25A6/COX8C/UQCRFS1/UQCRB/COX7A1/NDUFC1/UQCR10/COX7B/NDUFS8/VDAC3/VDAC1/NDUFA2/NDUFA4L2/NDUFB7/UQCRQ/NDUFS7/PRKCA/COX8A/MT-ND6/NDUFS3/NDUFA3/GYS1/NDUFS2/PLCB1/PPP1CB/G6PD/GFPT2/CAMK2D/RAC2/PDK4/NDUFA1/NDUFB4/NDUFB9	7.84540268286498
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	141/1959	388/9376	1.73928419191361	CALM1/TUBB/MT-CO3/MT-CYB/MT-CO1/MT-ATP6/GAPDH/TUBA1B/MT-ND1/MT-CO2/TUBA1C/MT-ND3/NDUFA4/MT-ND4/UQCRH/COX6C/CALM3/COX7C/COX5B/PSMA7/MT-ND5/DKK1/SDHA/MAP2K2/NRBF2/NDUFA8/UQCRC2/SDHB/PSMC5/COX5A/CASP3/PSMD13/SLC39A3/PPIF/NDUFA5/AKT2/FRAT2/SDHC/DVL3/MT-ND2/PSMD2/NDUFB6/HRAS/NDUFB2/CTNNB1/COX6B1/PSMC2/NDUFA10/PSMC6/EIF2AK3/UQCRC1/PSMC3/SDHD/NDUFS5/SLC25A5/INSR/NDUFS6/SLC25A4/AXIN2/PSMC1/TUBA1A/NAE1/PSMD12/PPID/NDUFB5/PSMB7/AKT1/CDK5/ADAM17/PSMC4/CSNK2B/EIF2S1/PSMD6/WNT10B/KLC2/CAPN1/NDUFA9/CYC1/NDUFV1/APP/PSMD7/ADRM1/PSMB1/PSMA4/MT-ND4L/SLC25A6/KRAS/COX8C/UQCRFS1/SNCA/UQCRB/PSMD3/PSMA6/TRAF2/COX7A1/NDUFC1/UQCR10/COX7B/FZD6/NDUFS8/WNT2/MCU/VDAC3/PSMD14/PIK3R4/AXIN1/VDAC1/NDUFA2/TUBB4B/ATG2A/IDE/NDUFA4L2/NDUFB7/UQCRQ/TUBB6/PSMD4/CSNK1E/NDUFS7/FZD5/COX8A/MT-ND6/NDUFS3/NDUFA3/BRAF/NDUFS2/CYCS/PLCB1/IL1B/PSMB4/WNT7A/PSMB5/PSMD11/NDUFA1/NDUFB4/AMBRA1/PTGS2/PSMB2/FZD1/CASP9/NDUFB9/PSMA1	7.64336267864822
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	163/1959	480/9376	1.62528500935852	CALM1/TUBB/MT-CO3/UBA52/MT-CYB/MT-CO1/MT-ATP6/RPS27A/TUBA1B/MT-ND1/MT-CO2/TUBA1C/MT-ND3/NDUFA4/MT-ND4/UQCRH/COX6C/HSPA5/CALM3/COX7C/COX5B/PSMA7/MT-ND5/DKK1/UBE2J2/SDHA/TARDBP/MAP2K2/NRBF2/NDUFA8/UQCRC2/SDHB/PSMC5/COX5A/CASP3/TANK/PSMD13/PPIF/NDUFA5/FRAT2/SDHC/DVL3/MT-ND2/PSMD2/NDUFB6/HRAS/ACTR1A/NDUFB2/HTT/CTNNB1/COX6B1/PSMC2/NDUFA10/PSMC6/EIF2AK3/ATXN3/UQCRC1/PSMC3/SDHD/NDUFS5/SLC25A5/HTRA2/ACTR1B/NDUFS6/SLC25A4/AXIN2/PSMC1/TUBA1A/PSMD12/DCTN3/PPID/NDUFB5/PSMB7/UBA1/CDK5/PSMC4/CSNK2B/C9orf72/EIF2S1/PSMD6/BAK1/GPX1/WNT10B/DNAH14/KLC2/CAPN1/DCTN5/TOMM40/NDUFA9/CYC1/NDUFV1/APP/PSMD7/ADRM1/PSMB1/PSMA4/MT-ND4L/WDR41/SLC25A6/KRAS/COX8C/UQCRFS1/SNCA/SIGMAR1/UQCRB/PSMD3/PSMA6/TRAF2/COX7A1/NDUFC1/UQCR10/COX7B/FZD6/NDUFS8/WNT2/MCU/FIG4/TRAP1/VDAC3/VCP/PSMD14/PIK3R4/AXIN1/VDAC1/NDUFA2/TUBB4B/ATG2A/NDUFA4L2/NDUFB7/UQCRQ/PLCG1/TUBB6/PSMD4/CSNK1E/NDUFS7/FZD5/PRKCA/COX8A/MT-ND6/NDUFS3/NDUFA3/BRAF/NDUFS2/CYCS/PLCB1/CAT/BCL2/IL1B/PSMB4/WNT7A/PSMB5/CAMK2D/PSMD11/PARK7/NDUFA1/NDUFB4/AMBRA1/PTGS2/PSMB2/FZD1/CASP9/NDUFB9/PSMA1	7.22753103571327
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	89/1959	227/9376	1.8764945704115	MGST1/CYBA/MT-CO3/MT-CYB/MT-CO1/MT-ATP6/MT-ND1/MT-CO2/MT-ND3/NDUFA4/MT-ND4/UQCRH/COX6C/COX7C/MGST3/COX5B/MT-ND5/GRB2/SDHA/MAP2K2/NDUFA8/UQCRC2/SDHB/COX5A/PPIF/NDUFA5/AKT2/SDHC/MT-ND2/NDUFB6/HRAS/NDUFB2/COX6B1/NDUFA10/ARNT/UQCRC1/SDHD/NDUFS5/SLC25A5/NDUFS6/SLC25A4/PTEN/NDUFB5/AKT1/PTPN1/PRKD3/HGF/MGST2/KEAP1/NDUFA9/CYC1/NDUFV1/MT-ND4L/SLC25A6/KRAS/COX8C/UQCRFS1/SRC/UQCRB/GSTM3/COX7A1/NDUFC1/UQCR10/COX7B/NDUFS8/CBR1/VDAC3/PLD2/VDAC1/NDUFA2/NDUFA4L2/NDUFB7/UQCRQ/NDUFS7/COX8A/MT-ND6/NDUFS3/NDUFA3/BRAF/ABL1/NDUFS2/GSTO2/CAT/NDUFA1/NDUFB4/SLC26A2/SLC26A6/EPHX2/NDUFB9	6.87011586644882
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	91/1959	235/9376	1.85334680090798	MT-CO3/MT-CYB/MT-CO1/MT-ATP6/ACTB/MT-ND1/MT-CO2/RPS6/MT-ND3/ACTG1/NDUFA4/MT-ND4/UQCRH/COX6C/COX7C/COX5B/MT-ND5/GRB2/SDHA/NDUFA8/UQCRC2/SDHB/COX5A/NDUFA5/CREB1/ACTL6A/COA4/COA5/SDHC/COX17/MT-ND2/NDUFB6/HRAS/NDUFB2/COX6B1/NDUFA10/CPT2/UQCRC1/SDHD/NDUFS5/COA3/COX11/NDUFS6/COX16/MLST8/NDUFB5/PRKAB1/NDUFAF3/CREB3L4/NDUFA9/COX15/CYC1/NDUFV1/NDUFAF7/MT-ND4L/COX10/KRAS/COX8C/UQCRFS1/UQCRB/COA1/COX7A1/NDUFC1/UQCR10/COX7B/KDM1A/NDUFS8/CPT1C/RPS6KA1/CREB3L1/NDUFAF6/NDUFA2/ADCY3/NDUFA4L2/NDUFB7/UQCRQ/NDUFS7/NDUFAF5/ADCY6/COX8A/MT-ND6/NDUFS3/NDUFA3/ACSL1/NDUFS2/ZNF516/ADCY5/NDUFA1/SMARCD3/NDUFB4/NDUFB9	6.80849868731336
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	54/1959	116/9376	2.22801922162961	GAPDH/ENO1/TPI1/PKM/GLUD1/SDHA/PRPS2/TKT/PGK1/SDHB/IDH3G/ACO2/IDH3A/ADPGK/SDHC/SDHD/IDH3B/PGD/PFKP/ME2/PFKL/ALDOA/PHGDH/ESD/GOT2/ADH5/PGLS/PGP/RPE/PDHA1/HIBCH/PDHB/DLAT/SUCLG1/PSPH/DLD/HK1/GPT2/DLST/PCCB/SHMT2/ACAT2/AMT/TALDO1/ACADS/ALDH6A1/ALDOC/FH/ECHS1/SUCLG2/PRPS1/PFKM/CAT/G6PD	6.83939021394048
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	29/1959	46/9376	3.01733359966265	PSMA7/PSMF1/PSMC5/PSMD13/PSMD2/PSMC2/PSMC6/PSMC3/PSME3/PSMC1/PSMD12/PSMB7/PSMC4/PSMD6/POMP/PSMD7/ADRM1/PSMB1/PSMA4/PSMD3/PSMA6/PSME2/PSMD14/PSMD4/PSMB4/PSMB5/PSMD11/PSMB2/PSMA1	7.0486270566786
Genetic Information Processing	Transcription	hsa03040	Spliceosome	89/1959	243/9376	1.75293937235971	SNRPD2/HNRNPA1/RBM8A/PRPF8/SNRPD1/CCDC12/DHX15/ZMAT2/HNRNPA3/SF1/SNRNP200/CWC25/HNRNPC/PPIE/SF3B3/SNRPF/SART1/SF3A3/PRPF31/U2AF1/SRSF4/RBM17/NCBP2/PUF60/THOC2/SMNDC1/PRPF3/DHX38/DDX23/SNRPB/RBMX2/RBM22/CASC3/ACIN1/TRA2B/MAGOHB/AQR/CDC40/SF3B4/PQBP1/PHF5A/SRSF1/EFTUD2/WBP11/SNRPG/TCERG1/USP39/CTNNBL1/SNRPC/U2SURP/SNRPE/EIF4A3/PLRG1/PRPF38B/CHERP/DHX16/SF3B5/SRSF10/SF3A2/PRPF19/NCBP1/DDX46/U2AF2/LSM5/SRSF3/SRSF6/LSM3/BUD13/PRPF40A/SNRNP40/DDX39B/PPIL1/PRPF4/PRPF38A/SRSF9/TXNL4A/SNRPD3/SNRNP70/THOC7/RBMXL1/HNRNPM/BCAS2/THOC1/PPIH/HNRNPU/SNRPB2/CWC15/RBMX/HNRNPA1L2	6.11146223345632
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	49/1959	108/9376	2.1714782674456	RAN/RBM8A/KPNA2/RANBP2/RNPS1/SUMO3/RANGAP1/PHAX/DDX19A/NCBP2/TPR/THOC2/SNUPN/NUP62/UPF1/CASC3/ACIN1/NUP98/MAGOHB/TNPO2/NUP54/IPO9/NUP133/EIF4A3/NUP155/NCBP1/GLE1/IPO11/XPO5/XPO4/RAE1/IPO8/IPO5/DDX39B/NUP88/AAAS/SEH1L/NUP188/CSE1L/THOC7/NUP43/XPO1/UPF3B/NUP85/THOC1/NUP160/NUP107/NUP35/KPNA5	6.29276941302686
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	64/1959	157/9376	1.95102791948316	LEP/MT-CO3/MT-CYB/MT-CO1/MT-CO2/NDUFA4/UQCRH/COX6C/COX7C/COX5B/ADIPOR2/SDHA/NDUFA8/UQCRC2/SDHB/COX5A/CASP3/NDUFA5/AKT2/SDHC/NDUFB6/NDUFB2/COX6B1/NDUFA10/EIF2AK3/UQCRC1/MAP3K11/SDHD/MLX/NDUFS5/INSR/NDUFS6/NDUFB5/AKT1/PRKAB1/EIF2S1/NDUFA9/CYC1/NDUFV1/COX8C/UQCRFS1/UQCRB/TRAF2/COX7A1/NDUFC1/UQCR10/COX7B/NDUFS8/NDUFA2/NDUFA4L2/NDUFB7/UQCRQ/NDUFS7/COX8A/NDUFS3/NDUFA3/NDUFS2/CYCS/IL1B/CDC42/IL6R/NDUFA1/NDUFB4/NDUFB9	6.17575277494032
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	29/1959	54/9376	2.57032121452744	UBE2T/RPA3/MUS81/RAD51/POLK/USP1/RPA1/RPA2/REV3L/TOP3A/ATR/TELO2/FANCE/BRCA2/BRCA1/FAN1/FANCB/PMS2/RMI2/BLM/FANCI/BRIP1/ATRIP/SLX4/EME1/MLH1/FANCD2/EME2/FANCF	5.94729587827286
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	23/1959	41/9376	2.68489398523388	ATM/SSBP1/NBN/RPA3/MUS81/RAD51/BARD1/RPA1/TOPBP1/RPA2/TOP3A/BRCA2/RAD54L/BRCA1/BLM/BRCC3/BRIP1/RAD51B/EME1/RAD52/POLD2/RAD54B/POLD1	5.55643276838931
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	21/1959	36/9376	2.79190062957291	POLE3/SSBP1/RNASEH1/RPA3/MCM6/RPA1/POLE4/RPA2/MCM4/MCM5/MCM7/PRIM1/RNASEH2B/RNASEH2C/FEN1/RFC2/POLE2/MCM2/POLD2/RNASEH2A/POLD1	5.53580076068938
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	42/1959	103/9376	1.95161985756553	RBM8A/DAZAP1/WDR33/PABPN1/RNPS1/TARDBP/PPP1CC/PCF11/CPSF6/HBS1L/DDX19A/NUDT21/NCBP2/SMG7/PPP2R3A/SMG6/CPSF2/PPP2R5C/UPF1/CPSF1/CASC3/ACIN1/MAGOHB/GSPT1/CSTF3/SMG5/FIP1L1/EIF4A3/PPP2R1A/NCBP1/GLE1/PABPC4/CLP1/PPP2R5D/DDX39B/CPSF4/CSTF1/PPP2R1B/CPSF3/UPF3B/PPP1CB/PABPC1L	4.99069115916241
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	33/1959	75/9376	2.10589076059214	CCNB1/RRM2/CCNE1/CDK1/CCNB2/CDK4/CHEK1/ATM/CASP3/PERP/GTSE1/MDM4/TP53/PTEN/RCHY1/EI24/CCND2/SFN/IGF1/ATR/CCNE2/TP53I3/THBS1/CCNG1/ZNF385A/CYCS/GADD45G/BCL2/DDB2/CCND1/PMAIP1/AIFM2/CASP9	4.94159052787389
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	17/1959	30/9376	2.71213204015654	SDHA/SDHB/IDH3G/ACO2/IDH3A/SDHC/ACLY/SDHD/IDH3B/PDHA1/PDHB/DLAT/SUCLG1/DLD/DLST/FH/SUCLG2	4.82696011490981
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	14/1959	23/9376	2.91328761346739	SSBP1/MSH6/RPA3/RPA1/MSH3/RPA2/EXO1/MLH3/PMS2/RFC2/MSH2/MLH1/POLD2/POLD1	4.72125467027986
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	53/1959	154/9376	1.64716957366268	GGH/CPOX/MAT2A/UROD/ALAS2/GMPPA/GGCX/PMM1/VKORC1L1/COASY/COQ4/RDH11/NADK/COQ5/FLAD1/PPOX/COX15/NADK2/NME1/COQ6/AK1/PPCDC/COX10/DLD/GCLM/FPGS/GSS/CTPS1/SHMT2/MOCS2/MPI/NFS1/AK3/COQ7/AK2/ADSL/CTPS2/ALDH2/OXSM/COQ2/CAD/DHFR/LIAS/ALAS1/KMO/PNPO/SPR/TPK1/KYNU/ALAD/UROS/NME1-NME2/MTHFD1L	4.16154513394165
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	22/1959	48/9376	2.19363620895014	HADHB/HIBADH/HMGCL/DBT/ALDH7A1/AACS/ALDH9A1/ACAA1/HIBCH/DLD/PCCB/ACAT2/ACAA2/HMGCS1/ACADS/ALDH6A1/ALDH2/ECHS1/ACAD8/OXCT1/MCCC2/IVD	4.26075979753264
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	20/1959	44/9376	2.17550698408279	HMGB1/POLE3/LIG3/SMUG1/PARP1/POLE4/XRCC1/APTX/NEIL2/TDP1/POLL/FEN1/RFC2/PARP2/POLE2/NEIL3/NTHL1/POLD2/POLD1/POLG2	4.0165474658009
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	29/1959	75/9376	1.85063127445976	GAPDH/ENO1/TPI1/PKM/MAT2A/CBS/PRPS2/TKT/PGK1/IDH3G/ACO2/IDH3A/IDH3B/PFKP/PFKL/ARG2/ALDOA/PHGDH/GOT2/RPE/PYCR2/PSPH/GPT2/SHMT2/TALDO1/ALDOC/PRPS1/PFKM/ASNS	3.80098251868288
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	29/1959	75/9376	1.85063127445976	MGST1/BIRC5/TOP2A/MGST3/TOP2B/ATM/BIRC2/CASP3/ERBB2/AKT2/MSH6/TP53/AKT1/XPA/BAK1/MSH3/MGST2/REV3L/GSTP1/GSTM3/BRCA1/CYCS/GSTO2/BIRC3/BCL2/MSH2/MLH1/PMAIP1/CASP9	3.80098251868288
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	68/1959	224/9376	1.45292787865529	RAN/CALR/PTTG1/CCNE1/CDC20/CCNB2/MAD2L1/HLA-G/RANBP1/CCNA2/CDK4/CHEK1/ATM/MAP2K2/DLG1/TBPL1/CREB1/AKT2/HRAS/GPS2/SLC25A5/ANAPC15/SLC25A4/SRF/TP53/PTEN/AKT1/CDC23/MAP3K1/CCND2/BUB1B/CREB3L4/SLC25A6/KRAS/ATR/MAD1L1/CCNE2/SPI1/HLA-C/ANAPC1/ELK1/NFYB/ANAPC10/CREB3L1/VDAC3/E2F1/VDAC1/ADCY3/CRTC1/ADCY6/XPO1/BUB3/CD4/HLA-A/ESPL1/ANAPC7/CDKN2C/HLA-DRB5/ITGAL/ADCY5/NFATC4/CCND1/ANAPC4/IL15/KAT2A/E2F2/MSX2/ANAPC2	3.52601189753671
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	25/1959	63/9376	1.89925212896116	POLR2B/POLE3/CETN2/CUL4A/POLR2E/RPA3/ERCC3/XPA/POLR2J3/RPA1/POLE4/POLR2D/RPA2/POLR2H/CCNH/GTF2H3/CDK7/POLR2G/ERCC8/RFC2/POLE2/DDB2/MNAT1/POLD2/POLD1	3.6804054455543
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	16/1959	34/9376	2.252289583521	POLR2B/POLR2E/POLR2J3/POLR3K/POLR3H/POLR2D/POLR3B/POLR3E/POLR2H/POLR3F/POLR1C/POLR3C/POLR2G/POLR1E/POLR1A/POLR3GL	3.75935217237138
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	38/1959	110/9376	1.65338530790292	LDHB/GAPDH/RPS6/TIMP1/ENO1/LDHA/MAP2K2/PGK1/CUL2/ANGPT4/ERBB2/AKT2/IGF1R/ARNT/INSR/PFKP/EGLN1/VHL/EIF4E/PFKL/ALDOA/AKT1/MKNK1/PDK1/TFRC/PDHA1/IGF1/PDHB/CDKN1B/HK1/ALDOC/PLCG1/PRKCA/PFKM/BCL2/IL6R/CAMK2D/EPO	3.54248708821783
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	47/1959	144/9376	1.56213487607056	PSMA7/NRBF2/AFG3L2/TBPL1/PSMC5/ATXN10/PSMD13/PPIF/AKT2/PSMD2/PSMC2/PSMC6/ATXN3/PSMC3/SLC25A5/SLC25A4/PSMC1/PSMD12/OPA1/PSMB7/AKT1/PSMC4/PSMD6/PSMD7/ADRM1/PSMB1/PSMA4/SLC25A6/PSMD3/PSMA6/TRAF2/MCU/VDAC3/PSMD14/PIK3R4/VDAC1/ATG2A/PSMD4/PRKCA/CYCS/PLCB1/PSMB4/PSMB5/PSMD11/AMBRA1/PSMB2/PSMA1	3.49351486505906
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	50/1959	157/9376	1.52424056209622	CCNB1/CALM1/CCNE1/CALM3/CDK1/CCNB2/HLA-G/CCNA2/CDK4/CHEK1/RBBP4/ATM/MAP2K2/RAD1/PPP1CC/RRAS/MYBL2/NBN/AKT2/E2F4/HRAS/SLC25A5/SLC25A4/TP53/HUS1/PPID/PTEN/AKT1/CCND2/CAPN1/SLC25A6/KRAS/ATR/CCNE2/RAD9A/HLA-C/FOXM1/MCU/VDAC3/LIN54/E2F1/VDAC1/CDC25A/HLA-A/GADD45G/PPP1CB/NFATC4/RBL1/CCND1/E2F2	3.40429554146157
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	44/1959	138/9376	1.52600779753054	CCNB1/CALM1/PTTG1/CCNE1/CALM3/CDC20/CDK1/CCNB2/MAD2L1/CUL1/PPP1CC/SMC3/AURKA/PKMYT1/IGF1R/PPP2R5C/PLK1/ANAPC15/SLK/CDC23/PPP2R1A/IGF1/BUB1/MAD1L1/CCNE2/YWHAH/ANAPC1/PPP2R5D/RPS6KA1/ANAPC10/YWHAE/ADCY3/PPP2R1B/ADCY6/ESPL1/ANAPC7/REC8/CDC25C/PPP1CB/CAMK2D/ADCY5/ANAPC4/ANAPC2/CPEB3	3.19912686681803
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	61/1959	205/9376	1.42416115738493	CALR/CCNE1/HLA-G/CCNA2/CDK4/STAT2/PSMC5/CASP3/PDIA3/PSMD13/HDAC2/AKT2/PSMD2/IRAK1/PSMC2/PSMC6/PSMC3/SIN3A/PSMC1/TP53/PSMD12/AKT1/POLK/IRF7/PSMC4/PSMD6/BAK1/CCND2/NEDD4/CDKN1B/OAS1/PSMD7/ADRM1/MAVS/IRF9/CCNE2/PSMD3/HLA-C/TRAF2/TYK2/PSMD14/E2F1/TAB1/PSMD4/CD58/CD44/HLA-A/IKBKE/VIM/CYCS/GADD45G/BCL2/DDB2/HLA-DRB5/ITGAL/PSMD11/CCND1/SKP2/E2F2/SAP30/CASP9	3.15564540240784
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	32/1959	93/9376	1.64683539440245	CCNE1/CDK4/ITGAV/BIRC2/LAMB1/CASP3/AKT2/CKS2/TP53/PTEN/AKT1/POLK/BAK1/TRAF4/CDKN1B/ZBTB17/CCNE2/TRAF2/E2F1/LAMA2/LAMA4/CYCS/BIRC3/GADD45G/BCL2/LAMC3/DDB2/CCND1/SKP2/PTGS2/E2F2/CASP9	3.22166064524993
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	18/1959	44/9376	1.95795628567451	TAF12/TBPL1/GTF2F1/TAF2/TAF10/GTF2A2/GTF2F2/ERCC3/TAF4/TAF15/CCNH/GTF2H3/TAF9/GTF2E1/TAF6L/CDK7/TAF8/MNAT1	3.27320632176101
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	14/1959	31/9376	2.16147145515322	PRPS2/TKT/PGM2/PGD/PFKP/PFKL/ALDOA/PGLS/RPE/TALDO1/ALDOC/PRPS1/PFKM/G6PD	3.32880573956638
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	30/1959	87/9376	1.65038460861453	MT-CO3/MT-CYB/MT-CO1/MT-CO2/UQCRH/COX6C/COX7C/COX5B/TPM4/ATP1A1/UQCRC2/MYL4/COX5A/COX6B1/TPM2/UQCRC1/ATP1B1/CYC1/COX8C/UQCRFS1/UQCRB/COX7A1/UQCR10/CACNB3/COX7B/UQCRQ/COX8A/ATP1B3/MYL3/TNNC1	3.1320891615039
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	30/1959	87/9376	1.65038460861453	BIRC5/GRB2/MAP2K2/RALA/CASP3/AKT2/HRAS/CTNNB1/MSH6/AXIN2/TP53/RAC3/AKT1/POLK/BAK1/MSH3/RALB/KRAS/AXIN1/BRAF/CYCS/GADD45G/BCL2/DDB2/MSH2/RAC2/CCND1/MLH1/PMAIP1/CASP9	3.1320891615039
Human Diseases	Cancer: specific types	hsa05214	Glioma	27/1959	76/9376	1.70033045861207	CALM1/CALM3/GRB2/CDK4/MAP2K2/SHC1/AKT2/IGF1R/HRAS/TP53/PTEN/AKT1/POLK/BAK1/IGF1/PDGFRA/KRAS/E2F1/PLCG1/PRKCA/PDGFA/BRAF/GADD45G/DDB2/CAMK2D/CCND1/E2F2	3.15033728746824
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	15/1959	35/9376	2.05119229927806	TPI1/GMPPA/PMM1/AKR1B1/PFKP/PFKL/ALDOA/PFKFB4/HK1/MPI/ALDOC/ENOSF1/PFKM/FPGT/KHK	3.20190338696628
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	22/1959	59/9376	1.78465318694249	GRB2/MAP2K2/ERBB2/AKT2/HRAS/CTNNB1/CTNNA1/AXIN2/TP53/PTEN/AKT1/POLK/BAK1/KRAS/ELK1/AXIN1/BRAF/GADD45G/DDB2/CCND1/MLH1/CASP9	3.10709418219293
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	59/1959	203/9376	1.39103845583225	COL1A1/COL1A2/ACTB/ACTG1/PGF/COL6A2/MYL9/COL6A3/GRB2/PPP1R12A/ITGAV/SHC1/PPP1CC/BIRC2/LAMB1/PPP1R12C/ERBB2/FLT4/AKT2/IGF1R/HRAS/CTNNB1/RAC3/PTEN/AKT1/CCND2/PAK1/HGF/COL9A3/IGF1/PIP5K1C/PDGFRA/ACTN1/MYL12A/SRC/DOCK1/COL6A1/ELK1/VCL/THBS1/FLNA/LAMA2/ITGB5/PRKCA/FYN/LAMA4/PDGFA/BRAF/BIRC3/PPP1CB/BCL2/CDC42/LAMC3/RAC2/CCND1/CAV1/VTN/TNXB/PAK4	2.89467965107194
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	24/1959	67/9376	1.71442938447121	LDHB/GAPDH/ENO1/LDHA/TPI1/PKM/PGM2/PGK1/ADPGK/PFKP/ALDH7A1/PFKL/ALDOA/ADH5/ALDH9A1/PDHA1/PDHB/DLAT/G6PC3/DLD/HK1/ALDH2/ALDOC/PFKM	3.016017878683
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	27/1959	78/9376	1.65673224172458	ENO1/HSPD1/EXOSC1/DCP1A/DCP2/XRN2/DHX36/EXOSC6/EXOSC4/C1D/PFKP/PFKL/PAN3/EXOSC10/CNOT8/CNOT10/LSM5/LSM3/PABPC4/EXOSC7/HSPA9/BTG1/PNPT1/BTG3/PFKM/PABPC1L/DCPS	2.99315760494204
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	59/1959	204/9376	1.38421963987228	COL1A1/COL1A2/DCN/MMP2/ACTB/RPS6/LUM/ACTG1/GRB2/HCLS1/PPP1R12A/MAP2K2/ITGAV/PPP1CC/CASP3/PPP1R12C/RRAS/ERBB2/AKT2/CTTN/IGF1R/HRAS/CTNNB1/TP53/AKT1/WNT10B/PAK1/HGF/SDC1/PTPN6/IGF1/TFAP4/KRAS/SRC/ELK1/FZD6/WNT2/HSPB2/THBS1/FLNA/ITGB5/PLCG1/TWIST1/GPC3/SDC2/CD44/FZD5/PRKCA/BRAF/HPSE/PPP1CB/CDC42/WNT7A/CAMK2D/CCND1/CAV1/VTN/FZD1/PLCE1	2.85135530648274
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	14/1959	33/9376	2.03047318514394	IDH3G/ACO2/IDH3A/IDH3B/DBT/GOT2/PDHA1/PDHB/DLAT/DHTKD1/DLD/GPT2/DLST/AADAT	3.04746837408497
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	34/1959	106/9376	1.53516907933389	CCNE1/HSP90AB1/GRB2/MAP2K2/ERBB2/CREB1/AKT2/IGF1R/HRAS/CTNNB1/TP53/PTEN/AKT1/IGF1/CREB3L4/PDGFRA/CDKN1B/GSTP1/ZEB1/KRAS/CCNE2/SLC46A1/CREB3L1/E2F1/MMP3/PDGFA/BRAF/ETV5/BCL2/CCND1/SLC19A1/PLAT/E2F2/CASP9	2.84769055846552
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	13/1959	30/9376	2.07398332482559	TYMS/GGH/ABCG2/ATIC/FPGS/ABCC1/SHMT2/SLC46A1/GART/DHFR/IL1B/ABCC5/SLC19A1	3.02784747404025
Cellular Processes	Cell motility	hsa04814	Motor proteins	56/1959	194/9376	1.38155907442783	TUBB/ACTB/TUBA1B/TUBA1C/ACTG1/MYL9/TPM4/CENPE/MYL6/ACTA2/MYL4/DYNC1LI1/ACTR1A/KIFC1/TPM2/KIF2C/KIF1C/KIF2A/KIF4A/ACTR1B/TNNI2/MYO1B/TUBA1A/DCTN3/KIF3A/KIF1B/DNAH14/KLC2/DCTN5/KIF23/KIF11/MYL12A/CAPZA1/KIF20B/KIF15/DYNLL2/TUBG1/KIFAP3/KIF14/KIF20A/MYH9/TUBB4B/TUBB6/TNNT1/KIFC3/KIF18A/MYO10/MYO1E/KIF18B/MYL3/TUBE1/MYL6B/MYO1F/CAPZB/TNNC1/MYO7A	2.75983249641996
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	7/1959	12/9376	2.79190062957291	GGCX/VKORC1L1/COQ4/COQ5/COQ6/COQ7/COQ2	3.19199762289385
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	68/1959	248/9376	1.31232195491446	TUBB/RPS3/ACTB/GAPDH/TUBA1B/TUBA1C/ACTG1/PFN1/MYL9/HSP90AB1/GSDMD/M6PR/MAP2K2/RALA/GCC2/RHOG/BIRC2/CASP3/DYNC1LI1/RRAS/ARPC5/AKT2/FBXO22/HRAS/VPS41/ACTR1A/IRAK1/CTNNB1/CASP4/ACTR1B/EXOC4/TUBA1A/DCTN3/AKT1/RIPK2/BAK1/PAK1/KLC2/DCTN5/FHOD1/MYL12A/VPS16/TXN2/DYNLL2/TRAF2/PIK3C2G/FLNA/NAIP/VPS18/TUBB4B/ARPC1A/CSE1L/TAB1/TUBB6/ARPC3/PTPRC/SNX18/CYCS/BIRC3/BCL2/IL1B/CDC42/NCKAP1L/IL18/TIRAP/ARPC4/PYCARD/CASP1	2.5617058247743
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	9/1959	19/9376	2.26710727814943	DBT/PDHA1/PDHB/DLAT/DHTKD1/DLD/DLST/AMT/LIAS	2.84125745270111
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	7/1959	13/9376	2.57713904268269	XRCC4/PRKDC/POLM/POLL/FEN1/XRCC6/XRCC5	2.92430632872618
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/1959	37/9376	1.81096257053378	MAP2K2/NCOA4/TPR/CCDC6/HRAS/CTNNB1/TP53/POLK/BAK1/KRAS/BRAF/GADD45G/DDB2/CCND1	2.54003792524882
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	41/1959	142/9376	1.38190654904414	UBE2C/UBA52/RPS27A/CDC20/UBE2J2/CUL1/UBA6/HERC4/CUL2/BIRC2/SAE1/CUL4A/HERC2/ANAPC15/VHL/MGRN1/UBA1/CDC23/RCHY1/MAP3K1/NEDD4/PRPF19/KEAP1/PML/UBE2F/ANAPC1/ANAPC10/RNF7/BRCA1/HERC3/UBE2S/ERCC8/ANAPC7/BIRC3/DDB2/UBE2N/SKP2/ANAPC4/RHOBTB2/ANAPC2/FBXW7	2.3566498477532
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	36/1959	122/9376	1.41229633720784	ACTB/ACTG1/ATP1A1/MAP2K2/ITGAV/HDAC2/AKT2/HDAC3/HRAS/PLCD4/CTNNB1/PFKP/SIN3A/PFKL/TP53/ATP1B1/BMP4/AKT1/MED27/DIO3/MED24/MED12/KRAS/SRC/PLCG1/PRKCA/MED30/ATP1B3/MED12L/PLCB1/PFKM/CCND1/SLC16A2/KAT2A/PLCE1/CASP9	2.35566408722171
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	33/1959	110/9376	1.43583460949464	CCNB1/HSP90AB1/CDK1/CCNB2/MAD2L1/CCNA2/AKT2/AURKA/PKMYT1/IGF1R/PLK1/ANAPC15/AKT1/GNAI3/CDC23/IGF1/BUB1/KRAS/MAD1L1/ANAPC1/RPS6KA1/ANAPC10/ADCY3/ADCY6/CDC25A/GNAI1/BRAF/ANAPC7/CDC25C/ADCY5/ANAPC4/ANAPC2/CPEB3	2.36298315566444
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	23/1959	71/9376	1.55043173795196	LDHB/SLC16A3/LDHA/PKM/MAP2K2/SCO2/ERBB2/AKT2/HRAS/PFKP/PFKL/TP53/PTEN/AKT1/PDK1/PDHA1/PDGFRA/PDHB/KRAS/HK1/FGFR3/PFKM/G6PD	2.39256182913684
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/1959	31/9376	1.85268981870276	HSPA5/SRP14/SEC61A1/SRP68/IMMP1L/SRP9/SGTA/UBL4A/SEC11A/SPCS3/OXA1L/SEC11C	2.44382997961247
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	47/1959	170/9376	1.32322013031859	MGST1/ACTB/ACTG1/MGST3/GRB2/CDK4/MAP2K2/SHC1/AKT2/ACTL6A/FRAT2/DVL3/IGF1R/HRAS/CTNNB1/TXNRD1/AXIN2/TP53/PTEN/AKT1/POLK/BAK1/WNT10B/HGF/ARID2/MGST2/KEAP1/GSTP1/KRAS/GSTM3/ELK1/FZD6/WNT2/E2F1/AXIN1/PLCG1/FZD5/PRKCA/BRAF/GSTO2/GADD45G/WNT7A/DDB2/CCND1/SMARCD3/E2F2/FZD1	2.18562723185456
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	17/1959	50/9376	1.62727922409393	ODC1/CKMT1A/CNDP2/ALDH7A1/SAT2/ARG2/CKMT1B/GOT2/CKB/GAMT/ALDH9A1/LAP3/PYCR2/ALDH2/SMS/SRM/GATM	2.28552995113887
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	23/1959	73/9376	1.50795415609026	GRB2/CDK4/STK4/MAP2K2/ERBB2/AKT2/HRAS/TP53/AKT1/POLK/BAK1/EML4/HGF/KRAS/E2F1/PLCG1/PRKCA/BRAF/GADD45G/DDB2/CCND1/E2F2/CASP9	2.23904671320083
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	28/1959	93/9376	1.44098097010215	ACTB/ACTG1/MYL9/PDCD10/ERBB2/IGF1R/CTNND1/CTNNB1/CTNNA1/ARHGAP29/INSR/LMO7/RAC3/PTPN1/CSNK2B/PTPN6/CDH5/ACTN1/MYL12A/SORBS1/SRC/VCL/SNAI2/FARP2/FYN/PTPRM/CDC42/RAC2	2.19637182655203
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	12/1959	32/9376	1.7947932618683	LDHB/LDHA/DBT/ECHDC1/HIBCH/SUCLG1/DLD/PCCB/ACADS/ALDH6A1/ECHS1/SUCLG2	2.3144695293207
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	55/1959	205/9376	1.28407973206838	CCNE1/CDC20/CDK1/GRB2/HLA-G/PKM/RANBP1/CCNA2/CDK4/CHEK1/SND1/DLG1/TBPL1/CASP3/MRPS18B/HDAC2/CREB1/HDAC3/HRAS/DNAJA3/DDX3X/PSMC1/SRF/GTF2A2/TP53/SCRIB/IRF7/BAK1/CCND2/RASA2/CREB3L4/CDKN1B/ACTN1/KRAS/MAD1L1/IRF9/CCNE2/SRC/YWHAH/HLA-C/TRAF2/CREB3L1/VDAC3/GTF2H3/HDAC10/YWHAE/GTF2E1/EGR3/HLA-A/CDC42/RBL1/CCND1/SKP2/KAT2A/PMAIP1	2.11347711786181
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	22/1959	70/9376	1.50420768613724	ACTB/ACTG1/HLA-G/CASP3/EIF4G1/RAC3/SGCB/HLA-C/LAMA2/SSPN/FYN/HLA-A/ABL1/CYCS/HLA-DRB5/ITGAL/RAC2/CCND1/SGCE/CAV1/SNTB2/CASP9	2.17603398771096
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	19/1959	59/9376	1.54129138872306	RRM2/MGST1/MGST3/PRDX6/ODC1/PGD/TXNDC12/GPX1/MGST2/LAP3/GSTP1/GCLM/GSTM3/GSS/SMS/GGCT/GSTO2/SRM/G6PD	2.14342253719263
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	47/1959	174/9376	1.29280127674805	PDIA6/CALR/HSPA5/HSP90AB1/UBE2J2/CUL1/SEC61A1/STT3A/UGGT1/WFS1/BAG1/OSTC/PDIA3/GANAB/NSFL1C/SSR2/UBXN1/PREB/DERL2/DNAJB12/EIF2AK3/ATXN3/PLAA/TUSC3/SAR1A/PRKCSH/DNAJB11/PDIA4/EIF2S1/BAK1/NGLY1/EDEM2/MAN1A2/CAPN1/DNAJC3/SEC23B/TRAF2/MBTPS2/VCP/HYOU1/SIL1/HSPBP1/MAN1C1/BCL2/SVIP/BAG2/LMAN2	2.0035269677976
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	41/1959	149/9376	1.31698476486086	MT-ND1/MT-ND3/NDUFA4/MT-ND4/MT-ND5/NDUFA8/NDUFA5/MT-ND2/NDUFB6/NDUFB2/NDUFA10/NDUFS5/NDUFS6/GNB2/NDUFB5/GNAI3/GNG11/NDUFA9/NDUFV1/MT-ND4L/NDUFC1/NDUFS8/NDUFA2/ADCY3/NDUFA4L2/NDUFB7/NDUFS7/PRKCA/ADCY6/MT-ND6/NDUFS3/NDUFA3/GNAI1/NDUFS2/PLCB1/ADCY5/NDUFA1/NDUFB4/PTGS2/GNG4/NDUFB9	2.0044257806938
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	18/1959	56/9376	1.53839422445854	STT3A/OSTC/DPM1/DPAGT1/GANAB/DPM3/TUSC3/MAN1A2/ALG12/ALG14/SRD5A3/DOLPP1/MGAT5B/MAN2A2/MAN1C1/ALG6/ALG9/ALG11	2.07670671137271
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	43/1959	158/9376	1.30255038414071	RPS6/GRB2/MAP2K2/ATP6V1A/AKT2/DVL3/IGF1R/HRAS/CLIP1/GRB10/INSR/SLC3A2/TBC1D7/EIF4E/SLC38A9/MLST8/PTEN/AKT1/LAMTOR2/WNT10B/ATP6V1B1/RRAGB/IGF1/NPRL2/STRADB/KRAS/TELO2/TTI1/FZD6/WNT2/RPS6KA1/ATP6V1C2/SEH1L/MIOS/FZD5/PRKCA/BRAF/PRR5/WNT7A/SKP2/LPIN3/FZD1/DDIT4	1.97104535123735
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	14/1959	41/9376	1.63428329535975	MMP2/CDK4/MAP2K2/ERBB2/HRAS/TP53/KRAS/SRC/E2F1/THBS1/FGFR3/BRAF/CCND1/E2F2	2.09173545496969
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/1959	30/9376	1.75490896716012	GPAA1/PIGF/PIGS/PIGX/PIGU/PIGG/PIGK/PIGW/PGAP2/PIGO/PIGB	2.12829115360546
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	35/1959	125/9376	1.340112302195	MAP2K2/GNA12/AKT2/PPP2R3A/HRAS/PRKCZ/PPP2R5C/CERS5/TP53/RAC3/PTEN/AKT1/GNAI3/SPTLC1/DEGS1/PPP2R1A/NSMAF/KRAS/ABCC1/TRAF2/GAB2/PPP2R5D/PLD2/SMPD2/PPP2R1B/PRKCA/FYN/SPHK2/GNAI1/ORMDL2/CERS6/PLCB1/BCL2/RAC2/S1PR3	1.96730512709162
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/1959	23/9376	1.87282775151475	ZMPSTE24/DHDDS/NUS1/PMVK/MVD/FNTB/ACAT2/HMGCS1/HMGCR	2.15380169148789
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	39/1959	142/9376	1.31449647348101	MGST1/CYBA/MMP2/CALM1/ACTB/ACTG1/CALM3/MGST3/HSP90AB1/SUMO3/ITGAV/AKT2/PRKCZ/CTNNB1/TP53/RAC3/BMP4/AKT1/MGST2/SDC1/KEAP1/GSTP1/CDH5/TXN2/SRC/GSTM3/MAPK7/THBD/ACVR2A/SDC2/VCAM1/PDGFA/GSTO2/BCL2/IL1B/RAC2/CAV1/PLAT/NPPC	1.94067912216473
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	25/1959	85/9376	1.40768098970063	RRM2/TYMS/TK1/NT5C3B/NT5C/NTPCR/ITPA/ENPP1/UCKL1/NME1/AK1/DTYMK/ASMTL/CTPS1/AK3/AK2/ENTPD6/ADSL/CTPS2/IMPDH2/HDDC2/PNP/ADA/NME1-NME2/IMPDH1	1.94038277254243
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	23/1959	77/9376	1.4296188752544	CDK4/RALA/ERBB2/AKT2/TP53/RAC3/RAD51/AKT1/POLK/BAK1/RALB/KRAS/BRCA2/PLD2/E2F1/BRAF/GADD45G/CDC42/DDB2/RAC2/CCND1/E2F2/CASP9	1.94535698732567
Human Diseases	Cancer: specific types	hsa05218	Melanoma	22/1959	73/9376	1.44239093191242	CDK4/MAP2K2/AKT2/IGF1R/HRAS/TP53/PTEN/AKT1/POLK/BAK1/HGF/IGF1/PDGFRA/KRAS/FGF7/E2F1/PDGFA/BRAF/GADD45G/DDB2/CCND1/E2F2	1.95004598381976
NA	NA	hsa04981	Folate transport and metabolism	11/1959	31/9376	1.69829900047753	TYMS/ABCG2/FPGS/ABCC1/SHMT2/SLC46A1/MTHFS/DHFR/ABCC5/SLCO2B1/SLC19A1	2.00134209963552
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	23/1959	78/9376	1.41129042813576	TPI1/PLCD4/MTMR2/PTEN/PIKFYVE/MTMR14/IPPK/PI4K2B/PPIP5K2/PIP5K1C/INPP5A/FIG4/PIK3C2G/ALDH6A1/ITPKB/PLCG1/ISYNA1/INPP4A/PLCB1/INPP4B/IMPA1/PLCE1/INPP5E	1.87451901186036
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	52/1959	200/9376	1.24438999489535	TUBB/RPS3/ACTB/GAPDH/TUBA1B/TUBA1C/ACTG1/NCL/TMBIM6/HCLS1/GNA12/CASP3/ARPC5/CTTN/IRAK1/NCK1/CASP4/MYO1B/TUBA1A/CLDN10/BAK1/PAK1/PTPN6/SRC/CLDN6/TRAF2/MYH9/NAIP/TUBB4B/ARPC1A/ABCF2/TAB1/TUBB6/ARPC3/FYN/MYO10/MYO1E/CLDN3/ABL1/CLDN12/CYCS/IL1B/CDC42/NCKAP1L/IL18/TIRAP/FCGR2A/ARPC4/MYO1F/PYCARD/CASP1/CASP9	1.79539674873623
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	13/1959	39/9376	1.59537178832738	TYMS/MAT2A/CBS/ALDH7A1/ATIC/DLD/SHMT2/AMT/AHCYL2/MTHFS/GART/DHFR/MTHFD1L	1.91472140589924
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	15/1959	47/9376	1.52748362712196	LDHB/LDHA/PKM/ALDH7A1/ME2/GRHPR/ADH5/ALDH9A1/PDHA1/PDHB/DLAT/DLD/ACAT2/ALDH2/FH	1.86306961515237
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	24/1959	83/9376	1.38393697300688	AURKB/RBBP4/MTF2/FBRSL1/PCGF3/HCFC1/HDAC2/RYBP/CSNK2B/RNF2/PCGF6/AEBP2/L3MBTL1/OGT/KDM2B/TEX10/TFDP1/RBBP7/CBX6/USP45/EZH1/WDR5B/SCML1/PHF19	1.80555087834786
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	24/1959	83/9376	1.38393697300688	MPV17/AGPS/HMGCL/ABCD3/PEX13/PEX19/PMVK/GNPAT/PEX26/ACAA1/NUDT19/FAR1/PXMP2/SLC27A2/PEX16/PEX5/HACL1/PEX1/ACSL1/MPV17L2/CAT/PEX11A/PECR/EPHX2	1.80555087834786
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	18/1959	59/9376	1.46017078931658	RRM2/TYMS/TK1/NT5C3B/NT5C/NUDT2/ENPP1/UCKL1/NME1/DTYMK/ASMTL/CTPS1/ENTPD6/CDADC1/CTPS2/HDDC2/CAD/NME1-NME2	1.82219865552586
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	19/1959	63/9376	1.44343161801048	SETD2/SMYD2/COLGALT1/ALDH7A1/KMT2D/ALDH9A1/SETDB1/DHTKD1/DLD/DLST/ACAT2/PLOD1/ALDH2/EZH1/SETMAR/SUV39H2/ECHS1/AASS/AADAT	1.81485046195228
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	23/1959	80/9376	1.37600816743236	RPS6/GRB2/MAP2K2/SHC1/ERBB2/AKT2/IGF1R/HRAS/EIF4E/PTEN/AKT1/HGF/IGF1/PDGFRA/KRAS/SRC/FGFR3/PLCG1/PRKCA/PDGFA/BRAF/BCL2/IL6R	1.73573304307168
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1959	29/9376	1.65038460861453	TEAD3/LATS2/PAK1/TEAD2/RASSF6/MOB1B/FRMD6/CSNK1E/WWC1/RASSF4	1.80269331988947
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	41/1959	157/9376	1.2498772609189	ACTB/ACTG1/BIRC5/DLG1/PPP1CC/BIRC2/DVL3/PRKCZ/CTNNB1/DLG5/CTNNA1/TEAD3/AXIN2/BMP4/SCRIB/PPP2R1A/CCND2/WNT10B/LATS2/TEAD2/RASSF6/YWHAH/MOB1B/FRMD6/FZD6/WNT2/BMP7/SNAI2/AXIN1/YWHAE/CSNK1E/PPP2R1B/FZD5/TP53BP2/WWC1/SMAD1/BIRC3/PPP1CB/WNT7A/CCND1/FZD1	1.62264446279667
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	22/1959	77/9376	1.36746153285204	GRB2/CDK4/MAP2K2/SHC1/HDAC2/CTBP1/AKT2/HRAS/TP53/AKT1/POLK/BAK1/CDKN1B/KRAS/GAB2/E2F1/BRAF/ABL1/GADD45G/DDB2/CCND1/E2F2	1.66390236016472
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	12/1959	37/9376	1.5522536318861	PGM2/GMPPA/PMM1/GALK2/CMAS/NAGK/HK1/MPI/GALT/GNPNAT1/GFPT2/FPGT	1.7297286216598
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/1959	57/9376	1.42743791587186	HADHB/CPT2/FADS2/ACAA1/PPT1/CBR4/ACAT2/CPT1C/ELOVL6/ACAA2/ACADS/HSD17B8/OXSM/ACSL1/MCAT/ELOVL2/ECHS1	1.66346831210563
NA	NA	hsa04518	Integrin signaling	40/1959	154/9376	1.24314684804731	COL1A1/COL1A2/ACTB/ACTG1/PGF/COL6A2/COL6A3/ITGAV/LAMB1/ERBB2/FLT4/AKT2/IGF1R/CTNNB1/RAC3/AKT1/CCND2/HGF/COL9A3/IGF1/FERMT1/PDGFRA/ACTN1/SRC/COL6A1/VCL/THBS1/FLNA/LAMA2/ITGB5/LAMA4/VCAM1/PDGFA/CDC42/LAMC3/ITGAL/RAC2/CCND1/VTN/TNXB	1.56352619700247
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	36/1959	137/9376	1.25766535138217	ACTB/TUBA1B/TUBA1C/ACTG1/BIRC5/LMNB1/ATM/MAP2K2/BIRC2/CASP3/AKT2/HRAS/EIF2AK3/CTSC/HTRA2/PARP1/TUBA1A/TP53/AKT1/AIFM1/LMNB2/EIF2S1/BAK1/CAPN1/KRAS/BCL2A1/TRAF2/CTSV/DFFA/PARP2/CYCS/BIRC3/GADD45G/BCL2/PMAIP1/CASP9	1.5613222149024
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	12/1959	38/9376	1.51140485209962	PGM2/GMPPA/PMM1/GALK2/NAGK/HK1/MPI/AMDHD2/GALT/GNPNAT1/GFPT2/FPGT	1.62337339590913
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	53/1959	212/9376	1.19652884124553	CALM1/ACTB/ACTG1/PFN1/CALM3/PGF/MAP2K2/RALA/ANGPT4/RRAS/FLT4/AKT2/IGF1R/HRAS/PRKCZ/CTNND1/CTNNB1/INSR/RAC3/AKT1/GNAI3/ENAH/PRKD3/HGF/IGF1/PDGFRA/RALB/EFNA4/KRAS/SRC/FGF7/THBS1/FGFR3/FARP2/ADCY3/APBB1IP/PLCG1/PRKCA/ADCY6/EFNA5/GNAI1/PDGFA/BRAF/PLCB1/CDC42/SIPA1L1/ITGAL/ADCY5/RAC2/LCP2/FPR1/SIPA1L2/PLCE1	1.48744323358828
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	23/1959	83/9376	1.32627293246493	GSDMD/CASP3/POLR2E/G3BP1/DDX41/IRF7/POLR3K/POLR3H/POLR3B/POLR3E/DNASE2/POLR2H/MAVS/POLR3F/POLR1C/POLR3C/IKBKE/POLR3GL/IL1B/IL18/PYCARD/CCL4L2/CASP1	1.53437262157772
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	31/1959	117/9376	1.26811603687561	ACTB/ACTG1/RBBP4/BAZ1A/POLE3/CHRAC1/UCHL5/HDAC2/ACTL6A/ING3/SS18/MEAF6/GATAD2A/INO80/SMARCA5/MRGBP/BRD9/MTA3/ACTR6/ARID2/YEATS4/BRD8/ACTR8/DMAP1/INO80B/INO80C/RBBP7/RUVBL2/TFPT/MTA2/SMARCD3	1.49976217709906
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	40/1959	157/9376	1.21939244967698	CALR/ODC1/MAP2K2/ITGAV/CASP3/CREB1/VPS41/ARNT/C1QA/C1QB/ARG2/ADAM17/PPARD/ATP11A/PTPN6/VPS8/VPS16/UQCRFS1/DOCK1/XKR8/C1QC/CPT1C/PLA2G15/CD47/THBS1/VPS18/ITGB5/ATP11C/PROS1/SPHK2/ATP11B/TYRO3/CAMK2D/NFATC4/DUSP5/PTGS2/EPO/DUSP16/CASP1/DUSP8	1.4246832318339
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	13/1959	43/9376	1.44696511034344	HADHB/CPT2/ALDH7A1/ADH5/ALDH9A1/ACAA1/ACAT2/CPT1C/ACAA2/ACADS/ALDH2/ACSL1/ECHS1	1.50968359366268
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	57/1959	233/9376	1.17085225666945	COL1A1/COL3A1/COL1A2/DCN/ACTB/ACTG1/COL6A2/ENO1/MYL9/DSC2/TPM4/COL6A3/LMNB1/COL5A2/ATP1A1/EMD/ITGAV/MYL4/PDLIM2/TPM2/TNNI2/NID1/ATP1B1/DIAPH3/LMNB2/PDLIM1/SDC1/COL9A3/LMOD1/CAPZA1/SGCB/SDC3/FLNC/COL6A1/VCL/LBR/MYH9/SYNPO2/THBS1/LAMA2/ITGB5/DES/SSPN/VCAN/COL27A1/TNNT1/SDC2/FHL3/FBLN2/ATP1B3/VIM/MYL3/SGCE/SNTB2/CAPZB/TNNC1/DSP	1.35719745562111
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	26/1959	98/9376	1.26978570907689	CALM1/CALM3/PLCD4/CDS2/MTMR2/PTEN/PIKFYVE/MTMR14/IPPK/PI4K2B/PPIP5K2/PIP5K1C/INPP5A/CDS1/PIK3C2G/ITPKB/PLCG1/INPP4A/PRKCA/PLCB1/INPP4B/DGKH/IMPA1/PLCE1/INPP5E/DGKQ	1.37972810584963
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	16/1959	56/9376	1.36746153285204	HSPD1/CASP3/HBS1L/HSF1/EEF1G/SAR1A/BCL2L13/BNIP3/VCP/NAIP/CYCS/IL1B/IL18/PYCARD/CASP1/CASP9	1.41738116194055
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	9/1959	28/9376	1.53839422445854	GGH/AKR1B1/QDPR/FPGS/MOCS2/CBR1/DHFR/PCBD1/SPR	1.46625252467249
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1959	32/9376	1.49566105155692	BIRC5/BIRC2/CASP3/HTRA2/BAK1/CYCS/BIRC3/BCL2/PMAIP1/CASP9	1.44338465829827
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	12/1959	41/9376	1.4008142531655	CBS/ALAS2/ALDH7A1/GRHPR/PHGDH/GAMT/PSPH/DLD/SHMT2/AMT/ALAS1/GATM	1.32180271865422
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	11/1959	37/9376	1.42289916256226	HBA2/HBA1/HBB/PRKCA/LAMA4/VCAM1/PLCB1/IL1B/IL18/F2RL1/THOP1	1.3245739698653
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1959	50/9376	1.340112302195	HBA2/HBA1/GYPC/GYPA/GYPB/HBB/HGF/SDC1/THBS1/SDC2/VCAM1/IL1B/ITGAL/IL18	1.23921982995736
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	32/1959	128/9376	1.19652884124553	RRM2/PRPS2/PGM2/NT5C/PDE4D/NUDT2/ATIC/NTPCR/ITPA/ENPP1/PDE7A/NME1/AK1/PAICS/AK3/HDDC3/AK2/ENTPD6/ADSL/IMPDH2/ADCY3/GART/ADCY6/HDDC2/PNP/ADA/PDE8A/PRPS1/ADCY5/PPAT/NME1-NME2/IMPDH1	1.1505250649245
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	17/1959	63/9376	1.29149144769359	DVL3/CTNNB1/AXIN2/TP53/BMP4/POLK/BAK1/WNT10B/FZD6/WNT2/AXIN1/SUFU/FZD5/GADD45G/WNT7A/DDB2/FZD1	1.19299880075161
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	12/1959	42/9376	1.36746153285204	ALDH7A1/ALDH9A1/DHTKD1/DLD/DLST/ACAT2/ALDH2/ECHS1/CAT/KMO/AADAT/KYNU	1.22656719732898
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	38/1959	155/9376	1.17337021851175	CCNE1/CDK4/MAP2K2/CREB1/DVL3/CTNNB1/ARNT/AXIN2/GNAI3/KMT2D/WNT10B/CREB3L4/NCEH1/CDKN1B/MEN1/CCNE2/FZD6/WNT2/CREB3L1/E2F1/AXIN1/ADCY3/WDR5B/FZD5/ADCY6/FH/GNAI1/BRAF/PDE8A/PLCB1/CDKN2C/CYP11A1/WNT7A/CAMK2D/ADCY5/CCND1/E2F2/FZD1	1.11851046379345
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	54/1959	227/9376	1.13854726744068	CALM1/CALR/CALM3/GRB2/HLA-G/CDK4/MAP2K2/ITGAV/GNA12/CASP3/PDIA3/CREB1/AKT2/HRAS/CTNNB1/CCL3L1/GNB2/TP53/RAC3/AKT1/GNAI3/GNG11/BAK1/CREB3L4/PDGFRA/CXCL12/KRAS/SRC/HLA-C/TRAF2/ELK1/IL10RA/CREB3L1/E2F1/ADCY3/PRKCA/ADCY6/CCL3/GNAI1/HLA-A/CYCS/PLCB1/IL1B/IL6R/CCL3L3/ADCY5/RAC2/NFATC4/CCND1/CCL4L2/PTGS2/E2F2/CASP9/GNG4	1.08595741768315
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	77/1959	333/9376	1.10669934865953	COL1A1/COL1A2/CCNE1/COL6A2/COL6A3/GRB2/HLA-G/PKM/CCNA2/CDK4/ATM/STAT2/MAP2K2/ITGAV/DLG1/TBPL1/ATP6V1A/LAMB1/CASP3/HDAC2/CREB1/AKT2/PPP2R3A/DVL3/HRAS/PRKCZ/CTNNB1/PPP2R5C/AXIN2/PSMC1/TP53/PTEN/SCRIB/AKT1/BAK1/PPP2R1A/CCND2/WNT10B/ATP6V1B1/COL9A3/CREB3L4/CDKN1B/TCIRG1/KRAS/ATR/IRF9/CCNE2/COL6A1/HLA-C/TUBG1/PPP2R5D/FZD6/WNT2/CREB3L1/TYK2/ATP6V1C2/E2F1/AXIN1/THBS1/LAMA2/ITGB5/PPP2R1B/FZD5/LAMA4/HLA-A/IKBKE/CDC42/LAMC3/WNT7A/RBL1/CCND1/VTN/ATP6V0E2/PTGS2/TNXB/FZD1/CRB3	1.01886427905474
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	36/1959	148/9376	1.16419022391457	GRB2/CDK4/MAP2K2/SHC1/ERBB2/FLT4/AKT2/FRAT2/DVL3/IGF1R/HRAS/CTNNB1/AXIN2/TP53/PTEN/AKT1/POLK/BAK1/WNT10B/IGF1/KRAS/FZD6/FGF7/WNT2/BRCA2/BRCA1/E2F1/AXIN1/FZD5/BRAF/GADD45G/WNT7A/DDB2/CCND1/E2F2/FZD1	1.03469673006701
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/1959	31/9376	1.38951736402707	CNDP2/ALDH7A1/ALDH9A1/HIBCH/ACADS/ALDH6A1/ALDH2/ECHS1/CSAD	1.11636633968162
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1959	31/9376	1.38951736402707	ACO2/GRHPR/PGP/DLD/PCCB/SHMT2/ACAT2/AMT/CAT	1.11636633968162
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/1959	27/9376	1.418108256291	HMGCL/AACS/ACAT2/HMGCS1/ACADS/ECHS1/OXCT1/L2HGDH	1.11808999792709
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/1959	15/9376	1.59537178832738	NTPCR/AK1/NFS1/AK2/TPK1	1.18593660829589
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	26/1959	105/9376	1.18513332847177	UBA52/RPS27A/RHOT2/RRAS/MTX2/HRAS/EIF2AK3/MTX1/FUNDC1/TP53/USP15/OPA1/CSNK2B/EIF2S1/TOMM40/SAMM50/BCL2L13/KRAS/TOMM20/SRC/BNIP3/TRAF2/VCP/E2F1/MTX3/AMBRA1	0.9804031207058
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	36/1959	150/9376	1.14866768759571	CCNE1/GRB2/MAP2K2/SHC1/ERBB2/AKT2/FRAT2/DVL3/HRAS/CTNNB1/CTNNA1/AXIN2/TP53/AKT1/POLK/BAK1/WNT10B/HGF/CDKN1B/KRAS/CCNE2/FZD6/FGF7/WNT2/E2F1/AXIN1/FZD5/BRAF/GADD45G/BCL2/WNT7A/DDB2/CCND1/MLH1/E2F2/FZD1	0.943287778138057
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	19/1959	75/9376	1.21248255912881	CGA/HSPA5/ATP1A1/CREB1/ATP1B1/PDIA4/GPX1/TTR/CREB3L4/TTF2/CREB3L1/LRP2/ADCY3/TTF1/PRKCA/ADCY6/ATP1B3/PLCB1/ADCY5	0.949462495705366
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/1959	32/9376	1.34609494640123	PGM2/AKR1B1/PFKP/PFKL/G6PC3/HK1/GALT/PFKM/GLA	1.00784222278705
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	43/1959	183/9376	1.12460634259143	RAN/UTP6/BMS1/REXO1/XRN2/MPHOSPH10/GNL2/WDR43/UTP18/UTP14A/RPP38/RIOK2/DKC1/LSG1/GTPBP4/GNL3/RIOK1/WDR36/CSNK2B/POP4/TCOF1/EMG1/FCF1/POP5/RPP25L/GAR1/NVL/IMP4/RPP30/GNL3L/RRP7A/PWP2/MDN1/XPO1/NOP58/POP7/HEATR1/WDR75/NOB1/NAT10/UTP15/WDR3/RBM28	0.87483425599318
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1959	89/9376	1.18308469696188	TUBB/TUBA1B/TUBA1C/CDK1/GRB2/MAP2K2/HRAS/TUBA1A/GNAI3/PDGFRA/KRAS/SRC/MAPK7/TUBB4B/ADCY3/TUBB6/PRKCA/ADCY6/GNAI1/PDGFA/PLCB1/ADCY5	0.891862785828349
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	40/1959	170/9376	1.1261447917605	ACTB/TUBA1B/TUBA1C/ACTG1/MYL9/JAM3/MYL6/CDK4/HCLS1/DLG1/ERBB2/ARPC5/CTTN/PRKCZ/HSPA4/TUBA1A/SCRIB/CLDN10/PRKAB1/MAP3K1/PPP2R1A/NEDD4/ACTN1/MYL12A/SRC/CLDN6/RAP2C/MPDZ/MYH9/ARHGAP17/ARPC1A/PPP2R1B/ARPC3/CLDN3/CLDN12/CDC42/CCND1/ARPC4/MYL6B/CRB3	0.852996042531817
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1959	54/9376	1.24084472425463	LDHB/LDHA/MAT2A/CBS/DNMT1/PHGDH/GOT2/MTAP/APIP/GCLM/GSS/AHCYL2/SMS/SRM	0.912154037410972
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	24/1959	99/9376	1.16027039151082	MMP2/GRB2/CDK4/MAP2K2/SHC1/ERBB2/AKT2/IGF1R/HRAS/TP53/AKT1/IGF1/CDKN1B/KRAS/SRC/E2F1/ADCY3/ADCY6/BRAF/CDKN2C/BCL2/ADCY5/CCND1/E2F2	0.823864583166614
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	57/1959	250/9376	1.09123430321593	HLA-G/SPG21/RAB11A/CHMP4B/VPS26A/EPN1/ARPC5/ZFYVE16/ARF3/IGF1R/HRAS/PRKCZ/RAB35/SNF8/RAB11FIP2/CHMP6/DAB2/RAB11FIP5/GRK6/ACAP2/NEDD4/TFRC/RUFY2/PIP5K1C/PDGFRA/PSD4/VPS37C/AP2A1/SNX5/PML/CAPZA1/VPS45/EHD2/SRC/HLA-C/AP2S1/GRK5/AP2M1/CHMP4A/PLD2/FGFR3/ARPC1A/PSD3/RAB11FIP3/ARPC3/VPS29/IQSEC2/RAB31/LDLRAP1/HLA-A/CDC42/AGAP5/ARPC4/CAV1/PSD/CAPZB/AGAP6	0.751409442666387
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	38/1959	163/9376	1.1157814961308	BIRC5/CCNE1/GRB2/CCNA2/STAT2/MAP2K2/CASP3/CREB1/AKT2/HRAS/IRAK1/DDX3X/TP53/AKT1/IRF7/MAP3K1/CREB3L4/MAVS/KRAS/CCNE2/SRC/ELK1/CREB3L1/VDAC3/TYK2/E2F1/TAB1/EGR3/PRKCA/IKBKE/BRAF/CYCS/BCL2/DDB2/TIRAP/NFATC4/E2F2/CASP9	0.766339375153251
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1959	42/9376	1.25350640511437	NCOA4/SLC40A1/SLC3A2/SAT2/TP53/TFRC/ATG7/GCLM/GSS/VDAC3/ACSL1	0.846190996953359
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	18/1959	73/9376	1.18013803520107	RAN/RANBP2/NELFB/PIN1/CHMP4B/CPSF6/MAP1B/CCNT1/NELFA/FURIN/CHMP6/NELFCD/BICD2/CHMP4A/XPO1/CD4/PSIP1/KAT2A	0.794043066295435
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1959	21/9376	1.36746153285204	AASDHPPT/COASY/ENPP1/PPCDC/ALDH2/CSAD	0.866339967497187
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	24/1959	101/9376	1.13729474019377	CALM1/CALM3/MAP2K2/CREB1/DVL3/HRAS/CTNNB1/GNAI3/WNT10B/CREB3L4/KRAS/FZD6/WNT2/CREB3L1/ADCY3/FZD5/PRKCA/ADCY6/GNAI1/PLCB1/WNT7A/CAMK2D/ADCY5/FZD1	0.712929103499298
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	24/1959	101/9376	1.13729474019377	COL1A1/COL3A1/COL1A2/MMP2/CDK4/CASP3/AKT2/HRAS/PLCD4/PRKCZ/AKT1/CDKN1B/KRAS/F3/THBD/PLCG1/PRKCA/VCAM1/PLCB1/BCL2/IL1B/CDC42/CCND1/PLCE1	0.712929103499298
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	36/1959	156/9376	1.10448816114972	GRB2/CDK4/STAT2/MAP2K2/CASP3/AKT2/HRAS/CTNNB1/PSME3/TP53/AKT1/IRF7/CLDN10/EIF2S1/BAK1/PPP2R1A/OAS1/MAVS/KRAS/EIF3E/IRF9/CLDN6/YWHAH/TRAF2/TYK2/E2F1/YWHAE/PPP2R1B/IKBKE/CLDN3/BRAF/CLDN12/CYCS/CCND1/E2F2/CASP9	0.676320640210236
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	13/1959	52/9376	1.19652884124553	CGA/IGF1R/INSR/IGF1/CYP19A1/HSD17B1/ADCY3/ADCY6/HSD17B2/CYP11A1/ADCY5/CYP2J2/PTGS2	0.730323961123822
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	32/1959	138/9376	1.10982385274948	CALM1/RPS6/CALM3/GRB2/MAP2K2/SHC1/PPP1CC/AKT2/HRAS/PRKCZ/PHKA2/INSR/EIF4E/AKT1/MKNK1/PTPN1/PRKAB1/PHKG2/G6PC3/KRAS/HK1/SORBS1/RHOQ/ELK1/INPP5A/PPP1R3B/BRAF/GYS1/PPP1R3E/PPP1CB/PRKAR2B/PHKA1	0.667937699018491
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	17/1959	70/9376	1.16234230292423	GRB2/MAP2K2/CUL2/PRCC/AKT2/HRAS/ARNT/EGLN1/VHL/AKT1/PAK1/HGF/KRAS/FH/BRAF/CDC42/PAK4	0.700628686390638
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	22/1959	93/9376	1.13219933365169	CGA/MMP2/CALM1/CALM3/GRB2/MAP2K2/HRAS/MAP3K1/KRAS/SRC/MAP3K4/ELK1/MAPK7/MMP14/PLD2/ADCY3/PRKCA/ADCY6/PLCB1/CDC42/CAMK2D/ADCY5	0.658438598505194
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	41/1959	180/9376	1.09017072202371	CALR/HLA-G/STAT2/PPP1CC/BIRC2/CASP3/PDIA3/SRSF4/HCFC1/AKT2/IRAK1/EIF2B5/EIF2B4/SRSF1/TP53/AKT1/IRF7/EIF2S1/BAK1/PILRB/OAS1/PML/SRSF3/MAVS/IRF9/SRC/SRSF6/HLA-C/TRAF2/SRSF9/TYK2/TAB1/HLA-A/IKBKE/CYCS/BIRC3/PPP1CB/BCL2/IL1B/HLA-DRB5/CASP9	0.627756235364725
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	27/1959	116/9376	1.11400961081481	CYBA/MMP2/ACTB/ACTG1/MYL9/JAM3/THY1/CTNND1/CTNNB1/CTNNA1/GNAI3/CLDN10/CXCL12/CDH5/ACTN1/MYL12A/CLDN6/VCL/PLCG1/PRKCA/GNAI1/VCAM1/CLDN3/CLDN12/CDC42/ITGAL/RAC2	0.634970693265857
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/1959	107/9376	1.1182512535005	LDHB/CALM1/CALM3/LDHA/PKM/CREB1/AKT2/PHKA2/PFKP/PFKL/AKT1/PRKAB1/PDHA1/PHKG2/CREB3L4/PDHB/G6PC3/CPT1C/CREB3L1/PRMT1/GYS1/PLCB1/PFKM/CAMK2D/PHKA1	0.632222456002291
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1959	53/9376	1.17395282537298	ATP1A1/RAB11A/ATP2B1/ATP1B1/AP2A1/AP2S1/AP2M1/PRKCA/ADCY6/ATP2B4/PTH1R/ATP1B3/PLCB1	0.652649930966179
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/1959	18/9376	1.32947649027281	CBR4/HSD17B8/OXSM/ACSL1/MCAT	0.71904799537755
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1959	18/9376	1.32947649027281	MMADHC/HCFC1/THAP11/MTRR/MMAA	0.71904799537755
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	28/1959	122/9376	1.09845270671721	LEP/CCNA2/ADIPOR2/CREB1/AKT2/PPP2R3A/IGF1R/PPP2R5C/INSR/PFKP/PFKL/AKT1/PFKFB4/PRKAB1/EEF2K/PPP2R1A/IGF1/CREB3L4/G6PC3/STRADB/PPP2R5D/CPT1C/CREB3L1/HMGCR/PPP2R1B/GYS1/PFKM/CCND1	0.562511680492062
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/1959	36/9376	1.19652884124553	PGM2/ENPP1/GYG2/G6PC3/HK1/AGL/PGM2L1/GYS1/GBE1	0.607145558693024
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1959	68/9376	1.1261447917605	GRB2/CCNA2/MAP2K2/AKT2/HRAS/AKT1/PPARD/PML/KRAS/BCL2A1/SPI1/RUNX1T1/BRAF/FCGR1A/PIM2/CCND1	0.5365180159619
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1959	23/9376	1.24855183434317	LNPEP/REN/PREP/ENPEP/NLN/THOP1	0.613329904212699
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/1959	82/9376	1.10897795042269	CALR/HSPA5/HSP90AB1/HLA-G/PDIA3/HSPA2/NFYC/CREB1/RFXANK/HSPA4/PSME3/HLA-C/PSME2/NFYB/IFI30/CD4/HLA-A/HLA-DRB5/RFXAP	0.509369509172659
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1959	32/9376	1.19652884124553	ATG3/ATG4C/MLST8/ATG10/ATG7/PIK3R4/ATG2A/ATG4A	0.572299787275832
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/1959	78/9376	1.10448816114972	ACTB/ACTG1/HCLS1/SHC1/RHOG/ARPC5/CTTN/CTNNB1/CTNNA1/SRC/DOCK1/VCL/ARPC1A/ARPC3/CDC42/ARPC4/CAV1/CD2AP	0.476220770508267
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	11/1959	46/9376	1.1445058481479	CPOX/UROD/ALAS2/HCCS/PPOX/COX15/COX10/ALAS1/FXN/ALAD/UROS	0.504907979163148
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1959	37/9376	1.16419022391457	GLUD1/RIMKLB/GOT2/GPT2/ADSL/CAD/GFPT2/PPAT/ASNS	0.514264666276282
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1959	28/9376	1.19652884124553	HADHB/PPT1/ELOVL6/ACAA2/ELOVL2/ECHS1/MBLAC2	0.535222884192382
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	14/1959	60/9376	1.11676025182916	MAP2K2/AKT2/HRAS/RAC3/AKT1/KRAS/SRC/PLCG1/PRKCA/SPHK2/CDC42/RAC2/PTGS2/CASP9	0.466277677872834
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1959	51/9376	1.1261447917605	ACTB/ACTG1/SEC61A1/ATP6V1A/PDIA4/ATP6V1B1/TCIRG1/ATP6V1C2/ADCY3/PLCG1/PRKCA/ATP6V0E2	0.464214507377182
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	47/1959	214/9376	1.05115617829047	CCNB1/CALM1/CALR/CALM3/CDK1/CCNB2/HLA-G/CHEK1/CUL1/ATM/MAP2K2/CASP3/PDIA3/AKT2/HRAS/IRAK1/CUL4A/GNB2/RAC3/AKT1/GNAI3/GNG11/BAK1/PAK1/AP1M2/CFL2/KRAS/ATR/CFL1/HLA-C/TRAF2/RNF7/TAB1/PLCG1/PRKCA/CD4/GNAI1/HLA-A/CYCS/CDC25C/BCL2/AP1G2/RAC2/NFATC4/PAK4/CASP9/GNG4	0.3890438478235
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/1959	154/9376	1.05667482084021	CALM1/CALM3/TPM4/ATP1A1/MYL4/PPP1CC/ATP2B1/CREB1/AKT2/PPP2R3A/TPM2/PPP2R5C/ATP1B1/AKT1/GNAI3/PPP2R1A/CREB3L4/PPP2R5D/CACNB3/CREB3L1/ADCY3/PPP2R1B/PRKCA/ADCY6/ATP2B4/GNAI1/ATP1B3/MYL3/PLCB1/PPP1CB/BCL2/CAMK2D/ADCY5/TNNC1	0.364440533799768
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/1959	98/9376	1.0744340615266	ARPC5/AKT2/AKT1/PAK1/PIP5K1C/CFL2/DOCK1/CFL1/GAB2/PLD2/ARPC1A/PLCG1/ARPC3/PRKCA/SPHK2/MYO10/PTPRC/FCGR1A/CDC42/RAC2/FCGR2A/ARPC4	0.380667927416134
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	38/1959	173/9376	1.05128545589203	ACTB/ACTG1/KPNA2/CDK4/PABPN1/STAT2/MAP2K2/RAB11A/CASP3/AKT2/NUP98/SLC25A5/SLC25A4/AKT1/IRF7/EIF2S1/BAK1/DNAJC3/OAS1/PML/MAVS/SLC25A6/IRF9/RAE1/CPSF4/TYK2/VDAC1/PRKCA/XPO1/IKBKE/CYCS/IL1B/HLA-DRB5/IL18/PYCARD/CASP1/KPNA5/CASP9	0.349897853049023
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/1959	38/9376	1.13355363907472	SIRT7/NT5C/ENPP1/NADK/NADK2/SIRT2/NNMT/PNP/NNT	0.423944793856805
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1959	38/9376	1.13355363907472	ATP1A1/INSR/ATP1B1/SFN/IGF1/KRAS/PRKCA/ATP1B3/HSD11B2	0.423944793856805
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1959	20/9376	1.19652884124553	FDFT1/MSMO1/LBR/LSS/NSDHL	0.452152463585391
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	23/1959	104/9376	1.05846782110182	PLA2G2A/ETNK1/PCYT1A/CDS2/PEMT/CEPT1/GNPAT/PLA2G10/PISD/PTDSS2/AGPAT4/PTDSS1/AGPAT5/LCLAT1/CDS1/GPD2/PLA2G15/PLD2/CHKA/GPD1L/DGKH/LPIN3/DGKQ	0.30813113546066
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1959	34/9376	1.1261447917605	CUL1/CREB1/NFIL3/PRKAB1/RORB/BHLHE40/CSNK1E/NPAS2	0.378684533656208
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	29/1959	133/9376	1.04358906454498	CCNB1/CCNB2/GRB2/STK4/ATM/MAP2K2/AKT2/IGF1R/HRAS/INSR/PLK1/PTEN/AKT1/PRKAB1/CCND2/IGF1/CDKN1B/G6PC3/KRAS/BNIP3/PRMT1/PLK4/CSNK1E/BRAF/GADD45G/CAT/CCND1/SKP2/FOXO4	0.260187009483039
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	19/1959	86/9376	1.05739758063559	GRB2/MAP2K2/SHC1/ERBB2/AKT2/HRAS/NCK1/AKT1/PAK1/CDKN1B/KRAS/SRC/ELK1/PLCG1/PRKCA/BRAF/ABL1/CAMK2D/PAK4	0.274804393710468
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1959	44/9376	1.08775349204139	STT3A/OSTC/TUSC3/MAN1A2/ALG12/ALG14/MAN2A2/MAN1C1/ALG9/ALG11	0.299841745601418
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/1959	44/9376	1.08775349204139	RAB11A/DYNC1LI1/CREB1/NSF/CREB3L4/DCTN5/DYNLL2/CREB3L1/ADCY3/ADCY6	0.299841745601418
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	24/1959	110/9376	1.04424335235974	DCN/CUL1/HDAC2/ZFYVE16/SKI/E2F4/EMP3/SIN3A/SMAD5/BMP4/PPP2R1A/TFRC/TFDP1/BMP7/THBS1/ACVR2A/PPP2R1B/SMAD1/GREM2/LRRC32/PITX2/RBL1/TMEM53/FMOD	0.239876077068345
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	11/1959	49/9376	1.0744340615266	C1GALT1/C1GALT1C1/COLGALT1/POGLUT1/EOGT/GALNT11/OGT/POFUT1/FUT10/GALNT10/GXYLT1	0.268464883183252
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1959	21/9376	1.1395512773767	CHSY1/XYLT1/CHST12/CHST11/CSGALNACT1	0.329010898551389
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/1959	144/9376	1.03034427996143	GRB2/REST/MAP2K2/PCGF3/AKT2/DVL3/IGF1R/HRAS/CTNNB1/DLX5/AXIN2/SMAD5/BMP4/AKT1/WNT10B/SMARCAD1/IGF1/SETDB1/PCGF6/KRAS/FZD6/WNT2/LIFR/AXIN1/FGFR3/ACVR2A/FZD5/SMAD1/WNT7A/FZD1/DUSP9	0.188581419917929
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/1959	78/9376	1.04312770775252	CALM1/CALM3/C1R/CASP3/IRAK1/C1QA/C1QB/GNAI3/C1S/CFL2/CFL1/C1QC/GNAI1/IL1B/TIRAP/PYCARD/CASP1	0.196561122237848
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	38/1959	178/9376	1.02175496555798	SERPINF1/DKK1/CUL1/TLE4/TLE1/CTBP1/CTNNBIP1/FRAT2/DVL3/CTNNB1/AXIN2/TP53/RAC3/LZTS2/CCAR2/RSPO3/PPARD/CSNK2B/CCND2/WNT10B/FRZB/FZD6/WNT2/TBL1X/AXIN1/CSNK1E/FZD5/PRKCA/INVS/PRICKLE3/APCDD1/PLCB1/WNT7A/CAMK2D/RAC2/NFATC4/CCND1/FZD1	0.150594952311138
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	39/1959	184/9376	1.01444836540382	MYL9/RRAS/EPHB3/SEMA7A/HRAS/PRKCZ/NCK1/EPHB4/ROBO1/RAC3/GNAI3/CDK5/ENAH/PAK1/SEMA6A/CXCL12/CFL2/LRIG2/MYL12A/EFNA4/KRAS/PLXNA3/SRC/CFL1/BMP7/PLCG1/SLIT2/EPHA1/PRKCA/FYN/EFNA5/GNAI1/ABL1/CDC42/SEMA4D/CAMK2D/RAC2/NFATC4/PAK4	0.101721167683803
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	49/1959	232/9376	1.0108605727764	ACTB/ACTG1/PFN1/MYL9/TMSB4X/PPP1R12A/MAP2K2/ITGAV/GNA12/PPP1CC/PPP1R12C/RRAS/ARPC5/AKT2/HRAS/RAC3/AKT1/PIKFYVE/ABI2/DIAPH3/ENAH/PAK1/PIP5K1C/PDGFRA/CXCL12/ACTN1/CFL2/MYL12A/KRAS/SRC/DOCK1/CFL1/VCL/FGF7/MYH9/FGFR3/ITGB5/ARPC1A/ARPC3/PDGFA/BRAF/PPP1CB/CDC42/NCKAP1L/IQGAP3/ITGAL/RAC2/ARPC4/PAK4	0.086082987472199
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/1959	60/9376	1.0369916624128	MAP2K2/GNA12/IGF1R/HRAS/GNAI3/PPP2R1A/IGF1/KRAS/PPP2R1B/PRKCA/GNAI1/BRAF/PLCB1	0.147724813712553
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1959	65/9376	1.03085561707307	LIPG/AKR1B1/ALDH7A1/ALDH9A1/AGPAT4/AGPAT5/LCLAT1/ALDH2/GLA/DGKH/AGK/LPIN3/ABHD16A/DGKQ	0.128286651028903
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1959	22/9376	1.08775349204139	CNDP2/ALDH7A1/ALDH9A1/HNMT/ALDH2	0.21177065603943
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	19/1959	89/9376	1.02175496555798	COL1A1/COL1A2/COL6A2/HMMR/COL6A3/ITGAV/LAMB1/SDC1/COL9A3/COL6A1/CD47/THBS1/LAMA2/ITGB5/CD44/LAMA4/LAMC3/VTN/TNXB	0.105975237199553
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	21/1959	99/9376	1.01523659257197	GRB2/MAP2K2/AKT2/PCYT1A/HRAS/RAC3/SLC44A2/AKT1/PIP5K1C/PDGFRA/KRAS/SLC44A1/PLD2/PLCG1/CHKA/PRKCA/SLC22A5/PDGFA/DGKH/RAC2/DGKQ	0.0783231941336855
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	23/1959	109/9376	1.00991425132651	PPP1CC/CREB1/AKT2/PRKCZ/MLX/INSR/PTEN/AKT1/PTPN1/PRKAB1/CREB3L4/G6PC3/SLC27A4/SLC27A3/OGT/SLC27A2/RPS6KA1/CREB3L1/PPP1R3B/GYS1/PPP1R3E/PPP1CB/GFPT2	0.0535047461894083
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/1959	76/9376	1.00760323473308	CALM1/ACTB/ACTG1/CALM3/ATP1A1/ATP1B1/GAST/GNAI3/ADCY3/PRKCA/ADCY6/GNAI1/ATP1B3/PLCB1/CAMK2D/ADCY5	0.0342020735931834
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1959	23/9376	1.04045986195264	GLUD1/ARG2/GOT2/GPT2/CAD	0.0998393084543041
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	13/1959	62/9376	1.003540318464	HDAC2/AKT2/IGF1R/HRAS/INSR/AKT1/PRKAB1/IGF1/KRAS/ADCY3/ADCY6/CAT/ADCY5	0.0143733756056874
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/1959	130/9376	0.994039345034751	COL1A1/COL3A1/COL1A2/MMP2/GRB2/ACTA2/MAP2K2/SHC1/CREB1/AKT2/HRAS/PRKCZ/GNB2/AKT1/GNAI3/GNG11/CREB3L4/KRAS/SRC/CREB3L1/ADCY3/PRKCA/ADCY6/GNAI1/PLCB1/ADCY5/GNG4	-0.0351704100328447
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	35/1959	169/9376	0.991207324108726	HMGB1/UBA52/RPS27A/ATG3/MAP2K2/NRBF2/RRAS/TANK/AKT2/IGF1R/HRAS/VPS41/EIF2AK3/UVRAG/ATG4C/MLST8/PTEN/AKT1/ATG10/C9orf72/EIF2S1/MTMR14/RRAGB/ATG7/VPS16/WDR41/KRAS/BNIP3/PIK3R4/VPS18/ATG2A/ATG4A/BCL2/AMBRA1/DDIT4	-0.0592780709542669
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	32/1959	155/9376	0.988101236641473	CYBA/TUBB/CALR/ACTB/TUBA1B/TUBA1C/ACTG1/C1R/HLA-G/M6PR/SEC61A1/ITGAV/ATP6V1A/DYNC1LI1/TUBA1A/PIKFYVE/CORO1A/ATP6V1B1/TFRC/TCIRG1/HLA-C/ATP6V1C2/THBS1/ITGB5/TUBB4B/TUBB6/HLA-A/FCGR1A/COLEC11/HLA-DRB5/FCGR2A/ATP6V0E2	-0.0767657296446956
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	52/1959	253/9376	0.98370750584613	UBA52/RPS27A/ACTB/ACTG1/PFN1/MYL9/CUL1/ATM/HCLS1/ARPC5/U2AF1/AKT2/CTTN/PLCD4/BCL10/CASP4/TP53/PPID/AKT1/RIPK2/RRAGB/CAPN1/MALT1/ACTN1/MYL12A/UBE2V1/HK1/SRC/DOCK1/BNIP3/TRAF2/VCL/PIK3R4/NAIP/VDAC1/ARPC1A/TAB1/PLCG1/CD44/ARPC3/CYCS/PLCB1/BCL2/IL1B/CDC42/UBE2N/IL18/ARPC4/PYCARD/FOXO4/CASP1/PLCE1	-0.135010552238756
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	25/1959	122/9376	0.980761345283224	GRB2/CDK4/MAP2K2/DLG1/AKT2/PPP2R3A/HRAS/NCK1/PPP2R5C/BCL10/AKT1/PPP2R1A/PAK1/PTPN6/MALT1/KRAS/PPP2R5D/PLCG1/PPP2R1B/FYN/CD4/PTPRC/CDC42/LCP2/PAK4	-0.109920472031556
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1959	19/9376	1.00760323473308	HYAL2/SGSH/HPSE/ARSB	0.0170488700700637
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	34/1959	166/9376	0.980288689213208	CALM1/CALM3/MYL9/ATP1A1/PPP1R12A/MAP2K2/GNA12/PPP1CC/PPIF/ATP2B1/CREB1/AKT2/SLC25A5/INSR/SLC25A4/SRF/ATP1B1/AKT1/GNAI3/CREB3L4/SLC25A6/CREB3L1/VDAC3/VDAC1/ADCY3/ADCY6/ATP2B4/GNAI1/ATP1B3/PLCB1/PPP1CB/ADCY5/NFATC4/NPPC	-0.131682617659015
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1959	14/9376	1.02559614963903	B4GALT4/CHST2/B3GNT2	0.0492541758496478
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	28/1959	138/9376	0.971095871155795	ACTB/ACTG1/MAP2K2/RHOG/ARPC5/AKT2/IRAK1/RAC3/AKT1/PIP5K1C/SRC/DOCK1/TRAF2/RPS6KA1/ARPC1A/TAB1/PLCG1/ARPC3/CD4/IL1B/CDC42/IL18/RAC2/FCGR2A/LCP2/ARPC4/PYCARD/CASP1	-0.175792023581357
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	18/1959	90/9376	0.957223072996427	ADIPOR2/CREB1/AKT2/IGF1R/HRAS/INSR/EIF4E/TP53/AKT1/PRKAB1/IGF1/CREB3L4/KRAS/CREB3L1/ADCY3/ADCY6/CAT/ADCY5	-0.209558467783375
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	31/1959	154/9376	0.963438807236663	CALM1/ACTB/ACTG1/CALM3/MYL9/MYL6/PPP1R12A/MAP2K2/PPP1CC/PPP1R12C/HRAS/GNAI3/PRKAB1/EEF2K/KRAS/SRC/ELK1/CACNB3/MAPK7/ADCY3/PRKCA/ADCY6/GNAI1/PLCB1/PPP1CB/CAMK2D/ADCY5/NFATC4/CCND1/MYL6B/PTGS2	-0.235102297801582
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1959	20/9376	0.957223072996427	GMPPA/CYB5R4/CMAS/NPL	-0.0984165622037814
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/1959	105/9376	0.957223072996427	ATM/BIRC2/IRAK1/BCL10/PARP1/CSNK2B/CXCL12/MALT1/BCL2A1/TRAF2/TAB1/PLCG1/EDARADD/VCAM1/BIRC3/GADD45G/BCL2/IL1B/TIRAP/CCL4L2/PTGS2	-0.226532051655428
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	23/1959	115/9376	0.957223072996427	NACA/MMP15/GNA12/CREB1/PDE4D/GNAI3/GCM1/NR4A2/CREB3L4/OXSR1/CREB3L1/MMP14/PLD2/ADCY3/PRKCA/ADCY6/GNAI1/BRAF/PTH1R/PLCB1/BCL2/ADCY5/MAFB	-0.2372019622503
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/1959	140/9376	0.957223072996427	CALM1/RPS6/CALM3/ACTA2/MAP2K2/MYL4/RRAS/AKT2/HRAS/GNB2/AKT1/GNAI3/GNG11/PRKAB1/KRAS/TFAM/NRF1/PIK3R4/ADCY3/ADCY6/SPHK2/GNAI1/MYL3/PLCB1/ADCY5/CCND1/PLAT/GNG4	-0.262071838288027
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/1959	61/9376	0.941530891471895	ATP1A1/SLC6A19/MT1E/ATP2B1/SLC40A1/ATP1B1/SLC46A1/CYBRD1/MT1M/ATP2B4/ATP1B3/SLC26A6	-0.23544456889494
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1959	10/9376	0.957223072996427	SELENBP1/BPNT1	-0.0695538577189298
Human Diseases	Infectious disease: viral	hsa05162	Measles	27/1959	136/9376	0.950184668047924	CCNE1/CDK4/STAT2/CASP3/AKT2/IRAK1/TP53/AKT1/IRF7/CSNK2B/EIF2S1/BAK1/RCHY1/CCND2/CDKN1B/OAS1/MAVS/IRF9/CCNE2/EIF3H/TYK2/IKBKE/CYCS/BCL2/IL1B/CCND1/CASP9	-0.300735857981949
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1959	26/9376	0.920406800958103	SLC5A6/BTD/ABCC1/SLC46A1/SLC19A1	-0.208855321665535
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/1959	82/9376	0.933876168777002	RRM2/MGST1/MGST3/TK1/ITPA/UCKL1/MGST2/GSTP1/NME1/GSTM3/CDADC1/IMPDH2/GSTO2/TPMT/NME1-NME2/IMPDH1	-0.309066772902546
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	40/1959	201/9376	0.952460769150673	CCNA2/ATM/BIRC2/BMP2K/CCNT1/PRCC/HDAC2/IGF1R/SS18/KDM6A/SIN3A/TP53/POLK/BAK1/CCND2/IGF1/CDKN1B/EWSR1/ZEB1/PML/MEN1/BCL2A1/ZBTB17/SPI1/RUNX1T1/TAF15/HOXA10/MMP3/MYCN/SMAD1/PDGFA/FCGR1A/ETV5/BIRC3/GADD45G/CDKN2C/DDB2/MLF1/MAF/PLAT	-0.350135269418748
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	43/1959	216/9376	0.952791484695517	CYBA/CALM1/HSPA5/CALM3/HSP90AB1/HSPD1/CASP3/TANK/HSPA2/AKT2/HRAS/IRAK1/EIF2AK3/CCL3L1/HSPA4/TP53/MIB2/AKT1/IRF7/EIF2S1/KRAS/SRC/TRAF2/MMP3/TAB1/PLCG1/PRKCA/CCL3/VCAM1/IKBKE/CYCS/PLCB1/BCL2/IL1B/CDC42/CCL3L3/CAMK2D/IL18/TIRAP/PYCARD/CYP2J2/CASP1/CASP9	-0.360734930412929
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	60/1959	300/9376	0.957223072996427	PGF/GRB2/STK4/MAP2K2/GNA12/ANGPT4/CASP3/RRAS/ERBB2/FLT4/MAP3K13/AKT2/PPM1B/IGF1R/HRAS/IRAK1/MAP3K11/INSR/SRF/RPS6KA4/TP53/RAC3/AKT1/MKNK1/MAP3K1/PAK1/RASA2/HGF/IGF1/PDGFRA/MAP4K2/STMN1/EFNA4/KRAS/MAP3K4/TRAF2/ELK1/CACNB3/PPP5C/FGF7/MAPK7/RPS6KA1/MAP4K4/ECSIT/FLNA/FGFR3/MAP3K6/TAB1/PRKCA/EFNA5/PDGFA/BRAF/GADD45G/IL1B/CDC42/RAC2/DUSP5/DUSP16/DUSP9/DUSP8	-0.387000639865316
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	37/1959	187/9376	0.946985393071331	CYBA/HSP90AB1/GSDMD/ANTXR2/STAT2/BIRC2/TANK/DNM1L/CASP4/GBP2/IRF7/RIPK2/OAS1/MAVS/TXN2/IRF9/TRAF2/DHX33/MCU/VDAC3/TYK2/TRIP6/YWHAE/NAIP/SUGT1/VDAC1/TAB1/IKBKE/GPSM3/BRCC3/PLCB1/BIRC3/BCL2/IL1B/IL18/PYCARD/CASP1	-0.376331819244661
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	19/1959	98/9376	0.927920325863883	CALM1/CALM3/ATP1A1/ATP2B1/CREB1/ATP1B1/PRKD3/NR4A2/CREB3L4/CREB3L1/ADCY3/PRKCA/ADCY6/ATP2B4/ATP1B3/PLCB1/CYP11A1/CAMK2D/ADCY5	-0.36862720640899
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1959	48/9376	0.89739663093415	ATP1A1/AKT2/ATP1B1/AKT1/G6PC3/HK1/ATP1B3/PLCB1/SLC37A4	-0.366249202838515
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/1959	134/9376	0.928649249921907	CALM1/CALM3/PLA2G2A/MYL9/RAMP1/MYL6/ACTA2/PPP1R12A/MAP2K2/GNA12/PPP1CC/PPP1R12C/RAMP2/PPP1R14A/PRKCH/PLA2G10/MYH9/ADCY3/PRKCA/ADCY6/BRAF/PLCB1/PPP1CB/ADCY5/MYL6B/NPPC	-0.427520236589736
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	29/1959	149/9376	0.931525809291825	GRB2/MAP2K2/SHC1/RALA/GNA12/RRAS/AKT2/HRAS/INSR/AKT1/AGPAT4/PIP5K1C/PDGFRA/AGPAT5/RALB/KRAS/GAB2/PLD2/ADCY3/PLCG1/PRKCA/ADCY6/FYN/SPHK2/PDGFA/PLCB1/DGKH/ADCY5/DGKQ	-0.432990630410451
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	72/1959	362/9376	0.951934547731253	COL1A1/COL1A2/RPS6/CCNE1/PGF/COL6A2/HSP90AB1/COL6A3/GRB2/CDK4/MAP2K2/ITGAV/ANGPT4/LAMB1/ERBB2/FLT4/CREB1/AKT2/PPP2R3A/IGF1R/HRAS/PPP2R5C/INSR/GNB2/EIF4E/TP53/MLST8/PTEN/AKT1/GNG11/PPP2R1A/CCND2/HGF/COL9A3/IGF1/CREB3L4/PDGFRA/CDKN1B/G6PC3/EFNA4/KRAS/CCNE2/YWHAH/COL6A1/PPP2R5D/FGF7/CREB3L1/BRCA1/THBS1/YWHAE/LAMA2/FGFR3/ITGB5/PPP2R1B/PRKCA/LAMA4/OSM/EFNA5/PDGFA/GYS1/BCL2/LAMC3/IL6R/CCND1/GHR/VTN/EPO/CSF3R/TNXB/CASP9/GNG4/DDIT4	-0.479310847948216
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/1959	69/9376	0.901731880358953	GRB2/MAP2K2/AKT2/HRAS/RAC3/AKT1/KRAS/GAB2/PLCG1/PRKCA/FYN/RAC2/LCP2	-0.421037764391485
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1959	59/9376	0.892326593471245	CGA/AKT2/INSR/AKT1/GNAI3/ABHD5/ADCY3/ADCY6/GNAI1/ADCY5/PTGS2	-0.426368516141525
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	23/1959	120/9376	0.917338778288242	CALM1/CALM3/GRB2/MAP2K2/SHC1/AKT2/HRAS/IRAK1/TP53/AKT1/RIPK2/MAP3K1/KRAS/MAPK7/RPS6KA1/YWHAE/PLCG1/BRAF/ABL1/BCL2/CDC42/CAMK2D/ZNF274	-0.468348880532426
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	20/1959	105/9376	0.911641021901359	CALM1/CALM3/STAT2/RRAS/AKT2/HRAS/BCL10/AKT1/PAK1/MALT1/KRAS/IRF9/SRC/EGR3/IKBKE/IL1B/NFATC4/PYCARD/PTGS2/CASP1	-0.467919086127673
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	20/1959	105/9376	0.911641021901359	ACTB/ACTG1/TPM4/EMD/ITGAV/TPM2/IGF1/SGCB/CACNB3/LAMA2/ITGB5/ADCY3/DES/SSPN/ADCY6/MYL3/ADCY5/SGCE/SNTB2/TNNC1	-0.467919086127673
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1959	17/9376	0.844608593820377	TXNRD1/SEPHS1/SEPSECS	-0.329553137360263
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1959	17/9376	0.844608593820377	TFRC/MYH9/NRP2	-0.329553137360263
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1959	28/9376	0.854663458032524	ATP6V1A/ATP6V1B1/TCIRG1/ATP6V1C2/ATP6V0E2	-0.395806756287725
Organismal Systems	Immune system	hsa04611	Platelet activation	24/1959	126/9376	0.911641021901359	COL1A1/COL3A1/COL1A2/ACTB/ACTG1/PPP1R12A/PPP1CC/AKT2/PRKCZ/AKT1/GNAI3/MYL12A/SRC/STIM1/ADCY3/APBB1IP/ADCY6/FYN/GNAI1/PLCB1/PPP1CB/ADCY5/FCGR2A/LCP2	-0.513161194456445
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1959	23/9376	0.83236788956211	GLUD1/ATP1A1/ATP1B1/ATP1B3	-0.413651287304091
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/1959	86/9376	0.890440067903653	ACTB/ACTG1/DSC2/EMD/ITGAV/CTNNB1/CTNNA1/SGCB/CACNB3/LAMA2/ITGB5/DES/SSPN/SGCE/SNTB2/DSP	-0.524543898563373
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1959	55/9376	0.870202793633115	CERS5/SMPD4/SPTLC1/DEGS1/SMPD2/GALC/SPHK2/CERS6/GLA/GBA2	-0.496139897590765
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	14/1959	76/9376	0.881652830391446	PLTP/DBI/FABP5/PLIN2/CPT2/FADS2/PPARD/ACAA1/SLC27A4/SLC27A2/SORBS1/CPT1C/HMGCS1/ACSL1	-0.53236796529319
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/1959	71/9376	0.876330982320672	CGA/GRB2/MAP2K2/SHC1/AKT2/HRAS/AKT1/CCND2/KRAS/SRC/ELF5/GALT/CCND1	-0.537552162684764
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	46/1959	238/9376	0.925047507517555	CALM1/CALM3/PGF/PLA2G2A/GRB2/STK4/MAP2K2/SHC1/RALA/ANGPT4/RRAS/FLT4/AKT2/IGF1R/HRAS/INSR/GNB2/RAC3/AKT1/GNG11/PLA2G10/PAK1/RASA2/HGF/IGF1/PDGFRA/RALB/EFNA4/KRAS/ELK1/GAB2/FGF7/PLD2/FGFR3/PLCG1/PRKCA/EFNA5/RALGAPA1/PDGFA/ABL1/CDC42/RAC2/FOXO4/PAK4/PLCE1/GNG4	-0.601918508714871
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1959	18/9376	0.797685894163689	MANBA/MAN2C1/GBA2	-0.441529385352337
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	19/1959	103/9376	0.882875649851073	COL1A1/COL3A1/COL1A2/COL6A2/COL6A3/COL14A1/COL5A2/ATP1A1/SLC6A19/COL18A1/SLC3A2/ATP1B1/COL9A3/SLC36A1/COL6A1/COL15A1/COL27A1/ATP1B3/COL16A1	-0.614248908494051
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	48/1959	250/9376	0.91893415007657	M6PR/ATP6V1A/VPS26A/VPS41/CTSC/NCOA7/SLC38A9/HYAL2/MLST8/PIKFYVE/BLOC1S2/LAMTOR2/ATP6V1B1/RRAGB/CTSE/SLC36A1/DNASE2/AP2A1/AP1M2/AP5B1/TCIRG1/PPT1/VPS16/MANBA/TELO2/TTI1/AP2S1/AP2M1/FIG4/SLC29A2/PLA2G15/SGSH/ATP6V1C2/CTSV/SLC29A1/VPS18/VPS13A/GALC/AP4M1/VPS29/LAPTM4B/GLA/AP1G2/ARSB/OSBPL6/ATP6V0E2/OSBPL3/LITAF	-0.667661646585669
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/1959	67/9376	0.857214692235606	CALM1/CALM3/MAP2K2/PPP1CC/HRAS/KRAS/RPS6KA1/PRKCA/BRAF/PLCB1/PPP1CB/CAMK2D	-0.60277901552077
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	18/1959	99/9376	0.870202793633115	ACTB/ACTG1/TPM4/EMD/ITGAV/TPM2/PRKAB1/IGF1/SGCB/CACNB3/LAMA2/ITGB5/DES/SSPN/MYL3/SGCE/SNTB2/TNNC1	-0.667218194899243
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/1959	196/9376	0.903501369920097	CALM1/UBA52/RPS27A/CALM3/HLA-G/CDK4/STAT2/ATG3/MAP2K2/CASP3/CREB1/AKT2/HRAS/CTNNB1/GNB2/TP53/AKT1/IRF7/GNG11/BAK1/KRAS/IRF9/SRC/HLA-C/TRAF2/TYK2/E2F1/PLCG1/HLA-A/IKBKE/CYCS/NFATC4/CCND1/PTGS2/E2F2/CASP9/GNG4	-0.70164358646778
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1959	63/9376	0.835670936742912	PTGDS/PLA2G2A/PTGES2/PLA2G10/CBR1/LTA4H/LTC4S/PTGES3/CYP2J2/PTGS2/EPHX2	-0.672556182850407
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	14/1959	79/9376	0.848172343161391	ATP6V1A/NSF/ATP6V1B1/AP2A1/TCIRG1/SLC1A2/AP2S1/AP2M1/ATP6V1C2/STX2/ATP6V0E2/CPLX1/SLC6A11/SYT1	-0.696436840265616
NA	NA	hsa04517	IgSF CAM signaling	57/1959	299/9376	0.912403263558467	TUBB/ACTB/TUBA1B/TUBA1C/ACTG1/MYL9/JAM3/GRB2/MYL6/MAP2K2/ARPC5/AKT2/CTNNB1/NCK1/ROBO1/TUBA1A/LMO7/EPB41L3/AKT1/PAK1/PTPN6/APP/ACTN1/CLMP/MYL12A/PLXNA3/DYNLL2/SORBS1/SRC/VCL/MPDZ/CNTNAP2/MYH9/GRIP1/TUBB4B/ARPC1A/PLCG1/CASKIN2/TUBB6/SLIT2/ARPC3/PRKCA/PTPRS/FYN/EPB41L2/ABL1/CDC42/DOK2/GLDN/NRP2/ITGAL/LCP2/ARPC4/MYL6B/CASK/CD2AP/PAK4	-0.791117641681363
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/1959	112/9376	0.854663458032524	BIRC2/LAMB1/CASP3/PPIF/AKT2/IRAK1/AKT1/GNAI3/IL10RA/TYK2/LAMA2/TAB1/LAMA4/GNAI1/CYCS/BIRC3/BCL2/LAMC3/HLA-DRB5/CASP9	-0.795194335108552
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1959	26/9376	0.736325440766482	PLA2G2A/FADS2/PLA2G10/ACAA1	-0.691891211141621
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/1959	71/9376	0.808920906757544	JAM3/ATP6V1A/CASP3/ADAM17/ATP6V1B1/PAK1/TCIRG1/SRC/ATP6V1C2/PLCG1/CDC42/ATP6V0E2	-0.830563561866924
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	21/1959	119/9376	0.844608593820377	BIRC2/CASP3/CREB1/AKT2/DNM1L/RPS6KA4/FRMD8/AKT1/ADAM17/CREB3L4/TRAF2/CREB3L1/MMP14/MMP3/TAB1/CCL20/VCAM1/BIRC3/IL1B/IL15/PTGS2	-0.876706168540646
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	11/1959	66/9376	0.797685894163689	HSD17B11/CYP19A1/SRD5A3/HSD17B1/HSD17B8/DHRS11/DHRS9/HSD17B2/CYP11A1/SRD5A1/HSD11B2	-0.847641102872629
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1959	27/9376	0.709054128145501	FADS2/ACAA1/ELOVL6/ELOVL2	-0.778036942260906
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1959	33/9376	0.725168994694263	USE1/BNIP1/VTI1A/STX6/STX2	-0.812771073485261
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	17/1959	99/9376	0.821858193986831	CALM1/CALM3/PPP1CC/PRKCH/IGF1/SRC/ADCY3/PLCG1/PRKCA/ADCY6/PLCB1/PPP1CB/IL1B/CAMK2D/ADCY5/F2RL1/CYP2J2	-0.915731991243553
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	35/1959	193/9376	0.867948382250646	CXCL14/GRB2/STAT2/SHC1/CCR7/AKT2/HRAS/PRKCZ/CCL3L1/GNB2/RAC3/AKT1/GNAI3/GNG11/GRK6/PAK1/CXCL12/CCL18/KRAS/SRC/GRK5/ADCY3/PLCG1/CCL20/ADCY6/CCL3/GNAI1/BRAF/PLCB1/CDC42/CCL3L3/ADCY5/RAC2/CCL4L2/GNG4	-0.95261804766064
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/1959	115/9376	0.83236788956211	CREB1/AKT2/HRAS/GNB2/AKT1/GNAI3/GNG11/CREB3L4/KRAS/CREB3L1/ADCY3/PRKCA/ADCY6/FYN/GNAI1/PLCB1/BCL2/CAMK2D/ADCY5/GNG4	-0.929535343403814
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1959	56/9376	0.769197112229272	CUL1/MGRN1/KIF3A/CCND2/LRP2/CSNK1E/SUFU/BCL2/CCND1	-0.890258261072009
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1959	45/9376	0.744506834552776	ABCG2/ABCD3/ABCB10/ABCC1/ABCB7/ABCC5/DEFB1	-0.88289725370194
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/1959	95/9376	0.806082587786465	ATP6V1A/CCL3L1/ATP6V1B1/CXCL12/TCIRG1/ATP6V1C2/MMP3/CCL20/CCL3/IL1B/HLA-DRB5/ITGAL/CCL3L3/IL18/ATP6V0E2/IL15	-0.976269990930076
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	21/1959	122/9376	0.823839530037908	GRB2/MAP2K2/SHC1/CREB1/AKT2/HRAS/AKT1/GNAI3/MAP3K1/IGF1/CREB3L4/KRAS/CREB3L1/ADCY3/PLCG1/PRKCA/ADCY6/GNAI1/PLCB1/ADCY5/GHR	-1.00649667539638
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	23/1959	133/9376	0.827674085673602	CALM1/CALM3/PPP1CC/CREB1/AKT2/PPP2R3A/PPP2R5C/GNB2/AKT1/GNAI3/GNG11/PPP2R1A/CREB3L4/PPP2R5D/CREB3L1/PPP2R1B/PRKCA/GNAI1/PLCB1/PPP1CB/CAMK2D/ADCY5/GNG4	-1.02862873459355
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1959	52/9376	0.736325440766482	PLTP/LIPG/STARD3NL/NCEH1/VDAC3/LRP2/VDAC1/LDLRAP1	-0.979845234554737
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	24/1959	139/9376	0.826379631363822	MMP2/CALM1/CALM3/HSP90AB1/GRB2/MAP2K2/SHC1/CREB1/AKT2/HRAS/FKBP4/AKT1/GNAI3/CREB3L4/KRAS/SRC/CREB3L1/GREB1/ADCY3/ADCY6/GNAI1/PLCB1/BCL2/ADCY5	-1.05981806755103
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1959	69/9376	0.763003898765268	CALM1/CALM3/PPP1CC/HDAC2/CREB1/CREB3L4/CREB3L1/PRKCA/PPP1CB/CAMK2D/ADCY5	-1.01542910353694
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1959	23/9376	0.624275917171583	B3GALNT2/MGAT5B/CHST10	-0.927141883062486
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/1959	65/9376	0.736325440766482	CREB1/CREB3L4/NCEH1/CREB3L1/ADCY3/ADCY6/PDE8A/PLCB1/CYP11A1/ADCY5	-1.09626477686318
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1959	17/9376	0.563072395880251	GLUD1/CA5B	-0.92663337231482
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1959	48/9376	0.697975157393228	CHMP4B/CLDN10/CLDN6/CHMP4A/CLDN3/CLDN12/EPCAM	-1.07809674135715
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1959	24/9376	0.598264420622767	XYLT1/HS3ST1/HS6ST1	-1.01270367229796
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/1959	49/9376	0.683730766426019	CREB1/GNAI3/CDK5/CREB3L4/CREB3L1/GNAI1/ADCY5	-1.14070334339543
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	31/1959	181/9376	0.819721416101912	CALM1/CALM3/HSPD1/CASP3/NFYC/CREB1/AKT2/IRAK1/BCL10/RFXANK/AKT1/CORO1A/RIPK2/MALT1/TCIRG1/SRC/HSPA9/IL10RA/NFYB/SPHK2/FCGR1A/CYCS/BCL2/IL1B/HLA-DRB5/CAMK2D/IL18/TIRAP/FCGR2A/RFXAP/CASP9	-1.25862477241404
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/1959	44/9376	0.652652095224836	HSPD1/HLA-G/HLA-C/HLA-A/IL1B/HLA-DRB5	-1.18684054247838
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1959	38/9376	0.629752021708175	RFXANK/CD4/PTPRC/ADA/RFXAP	-1.17529334221296
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1959	62/9376	0.694758682013536	TLE4/TLE1/HDAC2/CTBP1/DVL3/NUMB/ADAM17/DTX2/KAT2A	-1.23925238884943
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1959	91/9376	0.736325440766482	PDE4D/GNB2/GNAI3/GNG11/GRK6/PDE7A/GRK5/ADCY3/PRKCA/ADCY6/GNAI1/PDE8A/ADCY5/GNG4	-1.29893281193834
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	28/1959	168/9376	0.797685894163689	HMGB1/HSP90AB1/GLUD1/STAT2/CHMP4B/BIRC2/DNM1L/SLC25A5/PARP1/SLC25A4/CHMP6/PPID/AIFM1/CAPN1/SLC25A6/IRF9/TRAF2/SPATA2/VDAC3/TYK2/CHMP4A/VDAC1/BIRC3/BCL2/IL1B/CAMK2D/PYCARD/CASP1	-1.35983703872592
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1959	51/9376	0.656917795193626	PLA2G2A/AGPS/CEPT1/PLA2G10/PAFAH1B3/PLD2/ENPP2	-1.26254706572782
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/1959	103/9376	0.743474231453535	CALR/AKT2/IRAK1/CCL3L1/C1QA/C1QB/AKT1/GNAI3/PPP2R1A/C1QC/PPP2R1B/CCL3/GNAI1/PLCB1/IL1B/CCL3L3	-1.34532804775359
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	37/1959	217/9376	0.816065753476216	MGST1/BIRC5/MGST3/HSP90AB1/GRB2/KPNA2/MAP2K2/CDC6/CREB1/AKT2/HRAS/ARNT/AKT1/GNAI3/MGST2/CREB3L4/KRAS/SRC/GSTM3/FGF7/RPS6KA1/CREB3L1/E2F1/ADCY3/PRKCA/ADCY6/CDC25A/GNAI1/IKBKE/PTGES3/GSTO2/BCL2/ADCY5/CCND1/KPNA5/EPHX2/PAQR8	-1.40882533087888
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1959	88/9376	0.707039769826906	TFPI/CFD/C1R/C1QA/C1QB/C1S/PROCR/C1QC/F3/THBD/PROS1/VTN/PLAT	-1.41898438898624
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	23/1959	144/9376	0.764448981906868	ADIPOR2/CASP3/AKT2/IRAK1/CTNNB1/TRA2B/C1QA/ALDH7A1/C1QB/AKT1/ADH5/PRKAB1/ALDH9A1/IL17RA/C1QC/CPT1C/ALDH2/TAB1/IKBKE/IL1B/TIRAP/CCND1/LPIN3	-1.46388530265264
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1959	65/9376	0.662692896689834	CGA/MAP2K2/AKT2/HRAS/AKT1/KRAS/PRKCA/PLCB1/HCN2	-1.4024026338362
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1959	28/9376	0.512798074819514	B4GALT4/ST3GAL4/B3GNT2	-1.32683639676783
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1959	29/9376	0.495115382584359	CALM1/CALM3/SLC24A1	-1.39940600542341
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1959	36/9376	0.531790596109126	AKR1B1/RPE/CRYL1/FGGY	-1.44646077547212
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1959	36/9376	0.531790596109126	C1GALT1/C1GALT1C1/GALNT11/GALNT10	-1.44646077547212
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/1959	97/9376	0.690779537213916	CALM1/CALM3/CREB1/GNB2/GNAI3/GNG11/ADCY3/PRKCA/ADCY6/GNAI1/PLCB1/CAMK2D/ADCY5/GNG4	-1.57323001039475
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1959	103/9376	0.697007091987689	COL1A1/COL3A1/COL1A2/LAMB1/CASP3/ARG2/ACTN1/VCL/LAMA2/SERPINB9/PRKCA/LAMA4/PLCB1/IL1B/LAMC3	-1.58902109417344
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/1959	109/9376	0.702549044401047	STAT2/MAP2K2/AKT2/IRAK1/CCL3L1/AKT1/IRF7/IRF9/TYK2/TAB1/CCL3/IKBKE/IL1B/CCL3L3/TIRAP/CCL4L2	-1.60526875494581
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1959	43/9376	0.556525042439783	PLA2G2A/GOT2/PLA2G10/SLC27A4/ACAT2	-1.4978951424519
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	12/1959	86/9376	0.66783005092774	ATP1A1/CREB1/ATP1B1/CREB3L4/CREB3L1/ADCY3/PRKCA/ADCY6/ATP1B3/PLCB1/CAMK2D/ADCY5	-1.59034162159516
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1959	30/9376	0.478611536498213	PLA2G2A/PLA2G10/CYP2J2	-1.46993412813367
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	20/1959	133/9376	0.719716596237915	GRB2/HLA-G/MAP2K2/SHC1/CASP3/HRAS/RAC3/PAK1/PTPN6/KRAS/HLA-C/PLCG1/PRKCA/FYN/HLA-A/BRAF/SH3BP2/ITGAL/RAC2/LCP2	-1.67303660663185
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/1959	69/9376	0.624275917171583	CALM1/CALM3/CREB1/GNAI3/REN/ADCY6/GNAI1/PLCB1/ADCY5	-1.6098204426824
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1959	93/9376	0.669026878975997	CST3/CALM1/CALM3/ATP1A1/ATP2B1/ATP1B1/ADCY3/PRKCA/ADCY6/ATP2B4/ATP1B3/PLCB1/ADCY5	-1.64846124356507
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	31/1959	195/9376	0.760869622125365	CYBA/HMGB1/ACTB/ACTG1/GSDMD/MAP2K2/PPIF/HDAC2/AKT2/HDAC3/CASP4/SLC25A5/CLCN3/SLC25A4/AKT1/HAT1/ATG7/SLC25A6/SRC/VDAC3/HDAC10/VDAC1/PLCG1/PRKCA/FCGR1A/PLCB1/ITGAL/RAC2/FCGR2A/FPR1/CASP1	-1.7341864110404
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1959	15/9376	0.319074357665476	SLC33A1	-1.35635356361203
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1959	94/9376	0.661909571752848	HSP90AB1/CASP3/SRSF1/TRAF4/IL17RA/TRAF2/USP25/MAPK7/MMP3/CCL20/IKBKE/IL1B/PTGS2	-1.69303032447181
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/1959	70/9376	0.615357689783417	LEP/ADIPOR2/AKT2/AKT1/PRKAB1/G6PC3/TRAF2/CPT1C/ACSL1	-1.66001979572188
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1959	31/9376	0.46317245467569	ALDH7A1/ALDH9A1/ALDH2	-1.5385609401801
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/1959	45/9376	0.531790596109126	HLA-G/HLA-C/HLA-A/IL1B/HLA-DRB5	-1.61797203509957
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1959	89/9376	0.645318925615569	GNB2/GNAI3/GNG11/NSF/SRC/ADCY3/PRKCA/ADCY6/GNAI1/ADCY5/SLC6A11/GNG4	-1.72776237626764
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1959	39/9376	0.490883627177655	HLA-G/HLA-C/HLA-A/HLA-DRB5	-1.63732315882038
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	12/1959	90/9376	0.638148715330951	MAP2K2/AKT2/HRAS/PTEN/AKT1/CSNK2B/EML4/PTPN6/KRAS/PLCG1/CD4/TIRAP	-1.77266124736725
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1959	16/9376	0.299132210311383	GOT2	-1.44193898863846
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1959	16/9376	0.299132210311383	GLA	-1.44193898863846
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/1959	78/9376	0.613604533972068	CYBA/IRAK1/PTPN6/ELK1/TAB1/FCGR1A/IL1B/HLA-DRB5/FCGR2A/PTGS2	-1.76105641565509
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1959	72/9376	0.598264420622767	PIN1/SIKE1/TANK/DDX3X/IRF7/MAP3K1/MAVS/TRAF2/IKBKE	-1.75857303812909
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1959	17/9376	0.281536197940126	CSAD	-1.52371360726938
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	25/1959	168/9376	0.712219548360437	LEP/GRB2/STAT2/AKT2/HRAS/PTPN2/AKT1/CCND2/PTPN6/PDGFRA/IRF9/IL10RA/TYK2/LIFR/CNTFR/IL11RA/OSM/PDGFA/BCL2/IL6R/CCND1/GHR/IL15/EPO/CSF3R	-1.9342918060166
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/1959	160/9376	0.688004083716182	JAM3/HLA-G/ITGAV/CLDN10/SDC1/CDH5/SDC3/CLDN6/HLA-C/CNTNAP2/VCAN/SDC2/CD58/PTPRS/CD4/HLA-A/PTPRC/VCAM1/CLDN3/CLDN12/PTPRM/HLA-DRB5/ITGAL	-2.04562670463401
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/1959	70/9376	0.546984613140815	MGST1/MGST3/MGST2/GSTP1/GSTM3/CBR1/GSTO2/PTGS2	-1.95510085598595
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1959	102/9376	0.609995095536939	PLA2G2A/ATP1A1/RAB11A/ATP2B1/ATP1B1/PLA2G10/ADCY3/PRKCA/ADCY6/ATP2B4/ATP1B3/PLCB1/ADCY5	-2.03528543772855
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/1959	115/9376	0.624275917171583	CASP3/HRAS/GNB2/GNAI3/GNG11/APP/KRAS/PRKCA/GNAI1/BRAF/PLCB1/ADCY5/CYP2J2/PTGS2/GNG4	-2.08342431199301
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/1959	91/9376	0.578541417745093	GRB2/MAP2K2/AKT2/HRAS/BCL10/RAC3/AKT1/PTPN6/MALT1/KRAS/RAC2	-2.07621995445939
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1959	37/9376	0.388063407971524	GOT2/ADH5/GSTZ1	-1.91666324449076
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1959	79/9376	0.54525364917518	MGST1/MGST3/AKR7A2/ADH5/MGST2/GSTP1/GSTM3/CBR1/GSTO2	-2.08593162988353
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/1959	99/9376	0.58013519575541	CFD/C1R/C1QA/C1QB/C1S/C1QC/FCGR1A/HLA-DRB5/ITGAL/FCGR2A/FPR1/DEFB1	-2.1583009729651
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/1959	100/9376	0.574333843797856	CXCL14/CCR7/CCL3L1/CXCL12/CCL18/IL10RA/CCL20/CCL3/IL6R/CCL3L3/IL18/CCL4L2	-2.19926452246253
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/1959	100/9376	0.574333843797856	GYPA/CD7/TFRC/IL11RA/CD44/CD4/FCGR1A/IL1B/IL6R/HLA-DRB5/EPO/CSF3R	-2.19926452246253
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/1959	54/9376	0.443158830090938	CGA/HLA-G/HLA-C/HLA-A/HLA-DRB5	-2.10893106710616
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7/1959	68/9376	0.49268834639522	RDH11/ADH5/ALDH1A2/ALDH1A3/RETSAT/PNPLA4/DHRS9	-2.15769385376727
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1959	47/9376	0.407328967232522	PKM/PRKCZ/INSR/HK1	-2.09331121603661
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	33/1959	226/9376	0.698857553293851	CGA/CALM1/CALM3/MYL9/ATP1A1/PPP1R12A/MAP2K2/PPP1CC/RRAS/ATP2B1/CREB1/AKT2/PDE4D/ATP1B1/RAC3/AKT1/GNAI3/PAK1/CREB3L4/CREB3L1/PLD2/ADCY3/ADCY6/ATP2B4/GNAI1/BRAF/ATP1B3/PPP1CB/CAMK2D/ADCY5/RAC2/HCN2/PLCE1	-2.35507294784095
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1959	73/9376	0.458942569244862	MGST1/MGST3/ADH5/MGST2/GSTP1/GSTM3/GSTO2	-2.38496495689644
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	48/1959	323/9376	0.711249342164528	CCNE1/GRB2/ATM/MAP2K2/SHC1/CASP3/ERBB2/HDAC2/HRAS/MDM4/DNMT1/CDCA5/TP53/PTEN/TRIM71/BAK1/CCND2/PDGFRA/KIF23/CDKN1B/ZEB1/STMN1/EFNA4/KRAS/CCNE2/ABCC1/MAPK7/BRCA1/E2F1/THBS1/FGFR3/PLCG1/CCNG1/CD44/PRKCA/EFNA5/CDC25A/PDGFA/ABL1/VIM/CDC25C/BCL2/CCND1/PTGS2/E2F2/TNXB/PAK4/DDIT4	-2.71404284911568
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1959	90/9376	0.478611536498213	ATP1A1/ABCG2/ATP1B1/NCEH1/HMGCR/ADCY3/ADCY6/ATP1B3/ADCY5	-2.55421263715919
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/1959	142/9376	0.572985642286593	CYBA/GRB2/STAT2/CREB1/AKT2/AKT1/IRF9/SPI1/TRAF2/GAB2/TYK2/TAB1/FYN/FCGR1A/IL1B/FCGR2A/LCP2	-2.63499885930845
NA	NA	hsa04081	Hormone signaling	29/1959	219/9376	0.633777833719095	LEP/CGA/RAMP1/ADIPOR2/ITGAV/GNA12/IGF1R/RAMP2/INSR/SLC40A1/GNB2/SMAD5/GAST/GNAI3/GNG11/IGF1/SRC/ADCY3/ADCY6/SMAD1/GNAI1/PTH1R/PLCB1/ADCY5/GHR/SLC16A2/EPO/NPPC/GNG4	-2.81824531859131
NA	NA	hsa04519	Cadherin signaling	61/1959	404/9376	0.722656032831461	ACTB/ACTG1/DSC2/MAP2K2/RERE/PPP1CC/FAT2/RRAS/ERBB2/ARPC5/FLT4/DVL3/IGF1R/HRAS/CTNND1/CTNNB1/CTNNA1/TEAD3/AXIN2/MYO1B/CDH11/RAC3/ABI2/ENAH/WNT10B/LATS2/PDGFRA/TEAD2/CDH5/ACTN1/KRAS/YWHAH/MOB1B/VCL/MPDZ/FZD6/DSC3/WNT2/LHFPL2/AXIN1/YWHAE/DES/ARPC1A/PCDH10/FZD5/ARPC3/PRICKLE3/PCDH18/WWC1/MYO1E/VIM/PPP1CB/CDC42/WNT7A/NCKAP1L/RAC2/ARPC4/MYO1F/FZD1/DSP/MYO7A	-2.92855571151677
Human Diseases	Substance dependence	hsa05034	Alcoholism	24/1959	191/9376	0.601396695076289	CALM1/CALM3/GRB2/SHC1/PPP1CC/HDAC2/CREB1/HDAC3/HRAS/GNB2/GNAI3/GNG11/HAT1/CREB3L4/KRAS/SLC29A2/CREB3L1/SLC29A1/HDAC10/GNAI1/BRAF/PPP1CB/ADCY5/GNG4	-2.86026792013504
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/1959	116/9376	0.495115382584359	GNB2/GNAI3/GNG11/SLC1A2/PLD2/ADCY3/PRKCA/ADCY6/GNAI1/PLCB1/ADCY5/GNG4	-2.81192904044227
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1959	50/9376	0.287166921898928	CXCL12/HLA-DRB5/IL15	-2.59725061437483
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	34/1959	254/9376	0.640661111848002	CALM1/CALM3/ERBB2/PPIF/FLT4/ATP2B1/PLCD4/PHKA2/SLC25A5/SLC25A4/HGF/PHKG2/MST1/PDGFRA/SLC25A6/STIM1/FGF7/MCU/VDAC3/FGFR3/VDAC1/ADCY3/ITPKB/PLCG1/PRKCA/ATP2B4/SPHK2/PDGFA/PLCB1/CAMK2D/NFATC4/TNNC1/PLCE1/PHKA1	-2.98376599922095
Human Diseases	Immune disease	hsa05310	Asthma	1/1959	32/9376	0.149566105155692	HLA-DRB5	-2.47649726130269
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/1959	66/9376	0.290067597877705	IL1B/HLA-DRB5/IL18/MAF	-2.97442376453393
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/1959	143/9376	0.435101396816558	C1R/SNRPD1/SNRPB/C1QA/C1QB/C1S/ACTN1/C1QC/SSB/SNRPD3/FCGR1A/HLA-DRB5/FCGR2A	-3.49829007960966
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/1959	109/9376	0.307365206925458	HSP90AB1/TYK2/PLCG1/CD4/IL1B/IL6R/HLA-DRB5	-3.73797754211966
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/1959	93/9376	0.257318030375384	TYK2/PLCG1/CD4/HLA-DRB5/MAF	-3.69903888096085
NA	NA	hsa04382	Cornified envelope formation	21/1959	217/9376	0.46317245467569	S100A11/PADI1/PPP2R3A/PPP2R5C/FURIN/SPTLC1/CLDN10/PPP2R1A/CAPN1/SLC27A4/CLDN6/PPP2R5D/ABHD5/PPP2R1B/TMEM79/CLDN3/CLDN12/S100A16/GBA2/DSP/EPHX2	-4.11177504167841
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	30/1959	298/9376	0.481823694461289	LEP/CXCL14/CCR7/CCL3L1/BMP4/IL17RA/TNFRSF21/CXCL12/CCL18/IL10RA/BMP7/IL1RN/LIFR/CNTFR/IL11RA/ACVR2A/CCL20/CD4/OSM/CCL3/IL1B/IL6R/CCL3L3/IL18/GHR/CCL4L2/IL15/EPO/CSF3R/TNFSF12	-4.6717469400003
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1959	86/9376	0.111305008487957	ADCY6/PLCB1	-4.25483592917463
NA	NA	hsa04082	Neuroactive ligand signaling	14/1959	199/9376	0.336711633717336	OGFR/GNB2/GNAI3/GNG11/SLC1A2/ADCY3/PRKCA/ADCY6/OGFRL1/GNAI1/PLCB1/ADCY5/SLC6A11/GNG4	-4.86034691826031
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/1959	370/9376	0.168160810120994	LEP/CGA/NPW/OGFR/GAL/TMEM97/GZMA/OGFRL1/PTH1R/S1PR3/FPR1/GHR/F2RL1	-8.39001977688893
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1959	449/9376	0.0426379987971682	CALM1/CALM3/ADCY3/CAMK2D	-10.6840350881584