ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 125/3850 175/18639 0.714285714285714 3.45807050092764 1.3503502369557e-47 1.76220705922719e-44 GO:0140097 catalytic activity, acting on DNA 144/3850 336/18639 0.428571428571429 2.07484230055659 1.40096613047802e-20 9.14130400136909e-18 GO:0140098 catalytic activity, acting on RNA 156/3850 387/18639 0.403100775193798 1.95153125943824 4.56759107332835e-19 1.98690211689783e-16 GO:0140104 molecular carrier activity 113/3850 249/18639 0.453815261044177 2.1970552339227 1.0491152258168e-18 3.42273842422732e-16 GO:0009055 electron transfer activity 67/3850 116/18639 0.577586206896552 2.79626735333632 2.12196771290289e-18 5.53833573067654e-16 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 47/3850 68/18639 0.691176470588235 3.34619174942704 8.83209170774026e-18 1.92097994643351e-15 GO:0016887 ATP hydrolysis activity 156/3850 417/18639 0.37410071942446 1.81113332710455 1.37786726356972e-15 2.56873825565498e-13 GO:0008094 ATP-dependent activity, acting on DNA 94/3850 210/18639 0.447619047619048 2.16705751391466 2.48839272388619e-15 4.05919063083935e-13 GO:0140597 protein carrier chaperone 86/3850 188/18639 0.457446808510638 2.21463663995579 8.03272902743544e-15 1.16474570897814e-12 GO:0004386 helicase activity 74/3850 155/18639 0.47741935483871 2.31132970255551 3.8677710740873e-14 5.04744125168392e-12 GO:0003697 single-stranded DNA binding 62/3850 121/18639 0.512396694214876 2.48066545025223 7.85444683291994e-14 9.31823010632775e-12 GO:0140713 histone chaperone activity 76/3850 164/18639 0.463414634146341 2.2435286664555 1.25480286762907e-13 1.36459811854662e-11 GO:0015616 DNA translocase activity 71/3850 152/18639 0.467105263157895 2.2613961038961 4.90297683142478e-13 4.92183443462257e-11 GO:0000510 H3-H4 histone complex chaperone activity 70/3850 151/18639 0.463576158940397 2.24431065623119 1.12649484855755e-12 8.64750457275062e-11 GO:0140584 chromatin extrusion motor activity 70/3850 151/18639 0.463576158940397 2.24431065623119 1.12649484855755e-12 8.64750457275062e-11 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 70/3850 151/18639 0.463576158940397 2.24431065623119 1.12649484855755e-12 8.64750457275062e-11 GO:0140849 ATP-dependent H2AZ histone chaperone activity 70/3850 151/18639 0.463576158940397 2.24431065623119 1.12649484855755e-12 8.64750457275062e-11 GO:0140674 ATP-dependent histone chaperone activity 70/3850 152/18639 0.460526315789474 2.22954545454545 1.66958998976557e-12 1.21045274258004e-10 GO:0061775 cohesin loader activity 70/3850 153/18639 0.457516339869281 2.21497326203209 2.46081328294608e-12 1.69019017591823e-10 GO:0003689 DNA clamp loader activity 72/3850 160/18639 0.45 2.17858441558442 3.24866889788572e-12 2.11975645587044e-10 GO:0022853 active monoatomic ion transmembrane transporter activity 58/3850 118/18639 0.491525423728814 2.3796213955536 4.72404195952828e-12 2.90219762577953e-10 GO:0140658 ATP-dependent chromatin remodeler activity 71/3850 158/18639 0.449367088607595 2.17552030248233 4.97894626544655e-12 2.90219762577953e-10 GO:0019843 rRNA binding 39/3850 65/18639 0.6 2.90477922077922 5.11498432129726e-12 2.90219762577953e-10 GO:0008137 NADH dehydrogenase (ubiquinone) activity 29/3850 41/18639 0.707317073170732 3.42433322774786 7.0130005988587e-12 3.81331907562942e-10 GO:0003724 RNA helicase activity 43/3850 77/18639 0.558441558441558 2.70358239163434 1.21780531224938e-11 6.35694372994179e-10 GO:0003954 NADH dehydrogenase activity 30/3850 44/18639 0.681818181818182 3.30088547815821 1.34361081998662e-11 6.74389276954824e-10 GO:0008186 ATP-dependent activity, acting on RNA 43/3850 79/18639 0.544303797468354 2.6351372677955 3.81787544782581e-11 1.84530646644914e-09 GO:0043021 ribonucleoprotein complex binding 75/3850 177/18639 0.423728813559322 2.05139775478759 4.20610930475859e-11 1.96034737239641e-09 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 35/3850 58/18639 0.603448275862069 2.92147335423198 5.01951697320426e-11 2.25878263794192e-09 GO:0016651 oxidoreductase activity, acting on NAD(P)H 43/3850 88/18639 0.488636363636364 2.36563459268005 3.33444622882597e-09 1.4504841095393e-07 GO:0140101 catalytic activity, acting on a tRNA 59/3850 139/18639 0.424460431654676 2.05493973652247 4.48175321601706e-09 1.88667353125879e-07 GO:0015399 primary active transmembrane transporter activity 67/3850 166/18639 0.403614457831325 1.95401815052417 5.11633540175274e-09 2.08650553102729e-07 GO:0008173 RNA methyltransferase activity 35/3850 67/18639 0.522388059701492 2.52903663500678 1.04558507766067e-08 4.13481371620354e-07 GO:0016741 transferase activity, transferring one-carbon groups 80/3850 215/18639 0.372093023255814 1.80141347025068 1.4824690826194e-08 5.69006515534801e-07 GO:0008135 translation factor activity, RNA binding 39/3850 83/18639 0.469879518072289 2.27482710061023 6.87246384113087e-08 2.56244723219308e-06 GO:0180051 translation factor activity 39/3850 84/18639 0.464285714285714 2.24774582560297 1.02833352713795e-07 3.72770903587508e-06 GO:0008168 methyltransferase activity 74/3850 204/18639 0.362745098039216 1.75615737203972 1.67580892415267e-07 5.91062336761954e-06 GO:0003684 damaged DNA binding 35/3850 74/18639 0.472972972972973 2.28980343980344 2.6103221503849e-07 8.96439580592708e-06 GO:0003688 DNA replication origin binding 13/3850 16/18639 0.8125 3.93355519480519 3.63443536919633e-07 1.21613798892339e-05 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 62/3850 167/18639 0.37125748502994 1.79736838012287 6.51484954553373e-07 2.12546966423038e-05 GO:0043022 ribosome binding 46/3850 112/18639 0.410714285714286 1.9883905380334 6.83475863210367e-07 2.17545366216958e-05 GO:0000049 tRNA binding 36/3850 80/18639 0.45 2.17858441558442 8.1300609597684e-07 2.52612608392804e-05 GO:0051540 metal cluster binding 35/3850 77/18639 0.454545454545455 2.20059031877214 8.58808444527645e-07 2.60638376769437e-05 GO:0003678 DNA helicase activity 34/3850 74/18639 0.459459459459459 2.22438048438048 9.01222029016242e-07 2.67294260878681e-05 GO:0051539 4 iron, 4 sulfur cluster binding 24/3850 45/18639 0.533333333333333 2.58202597402597 1.3097120741704e-06 3.79816501509416e-05 GO:0051536 iron-sulfur cluster binding 34/3850 76/18639 0.447368421052632 2.16584415584416 1.92132370218066e-06 5.39298602933606e-05 GO:0030515 snoRNA binding 19/3850 32/18639 0.59375 2.8745211038961 1.94230148182985e-06 5.39298602933606e-05 GO:0070034 telomerase RNA binding 15/3850 22/18639 0.681818181818182 3.30088547815821 1.98589845504415e-06 5.39916142465128e-05 GO:0051082 unfolded protein binding 47/3850 121/18639 0.388429752066116 1.88050445422346 3.38384909193574e-06 9.01208788770641e-05 GO:0070063 RNA polymerase binding 28/3850 59/18639 0.474576271186441 2.2975654853621 3.71025506390116e-06 9.68376571678204e-05 GO:0031720 haptoglobin binding 9/3850 10/18639 0.9 4.35716883116883 5.5332407568557e-06 0.000141585866425425 GO:0003743 translation initiation factor activity 25/3850 51/18639 0.490196078431373 2.37318563789152 5.8970610339199e-06 0.000147993550947413 GO:0016423 tRNA (guanine) methyltransferase activity 10/3850 12/18639 0.833333333333333 4.03441558441558 6.10722929862383e-06 0.000150376117635926 GO:0008175 tRNA methyltransferase activity 19/3850 34/18639 0.558823529411765 2.70543162719633 6.74572665396675e-06 0.000163021727470863 GO:0044389 ubiquitin-like protein ligase binding 99/3850 322/18639 0.307453416149068 1.48847382431233 1.10205196973165e-05 0.000259826465179027 GO:0016853 isomerase activity 62/3850 180/18639 0.344444444444444 1.66755844155844 1.11496414176441e-05 0.000259826465179027 GO:0003713 transcription coactivator activity 82/3850 256/18639 0.3203125 1.55072849025974 1.17077661281707e-05 0.000268046224513382 GO:0015078 proton transmembrane transporter activity 63/3850 185/18639 0.340540540540541 1.64865847665848 1.4335256451741e-05 0.000322543270164172 GO:0003712 transcription coregulator activity 141/3850 495/18639 0.284848484848485 1.37903659976387 1.65935594161035e-05 0.000365192959671634 GO:0015631 tubulin binding 114/3850 385/18639 0.296103896103896 1.43352740765728 1.67904809044429e-05 0.000365192959671634 GO:0031625 ubiquitin protein ligase binding 93/3850 302/18639 0.30794701986755 1.49086350735357 1.8699175912484e-05 0.000400039746980191 GO:0017069 snRNA binding 25/3850 54/18639 0.462962962962963 2.24134199134199 2.0852337183497e-05 0.000438908064910704 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 23/3850 48/18639 0.479166666666667 2.31978896103896 2.21759691732396e-05 0.000459359361445678 GO:0016779 nucleotidyltransferase activity 49/3850 136/18639 0.360294117647059 1.74429144385027 2.35924804657384e-05 0.000481065421996696 GO:0048027 mRNA 5'-UTR binding 14/3850 24/18639 0.583333333333333 2.82409090909091 5.92734617355084e-05 0.00118174078335362 GO:0042393 histone binding 77/3850 247/18639 0.311740890688259 1.50923076923077 5.97662005374243e-05 0.00118174078335362 GO:0019887 protein kinase regulator activity 79/3850 255/18639 0.309803921568627 1.49985332314744 6.11247158615853e-05 0.00119056349551297 GO:0051287 NAD binding 24/3850 54/18639 0.444444444444444 2.15168831168831 6.90191359296407e-05 0.00132455841747325 GO:0004527 exonuclease activity 33/3850 84/18639 0.392857142857143 1.9019387755102 7.12712772665685e-05 0.0013479567656938 GO:0036121 double-stranded DNA helicase activity 22/3850 48/18639 0.458333333333333 2.21892857142857 7.79500458519767e-05 0.00145321156909757 GO:0000217 DNA secondary structure binding 19/3850 39/18639 0.487179487179487 2.35858141858142 8.56308378517991e-05 0.00157391892107884 GO:0017116 single-stranded DNA helicase activity 25/3850 58/18639 0.431034482758621 2.08676668159427 9.07933853342831e-05 0.00160823695655575 GO:0034062 5'-3' RNA polymerase activity 13/3850 22/18639 0.590909090909091 2.86076741440378 9.11950458123567e-05 0.00160823695655575 GO:0097747 RNA polymerase activity 13/3850 22/18639 0.590909090909091 2.86076741440378 9.11950458123567e-05 0.00160823695655575 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 12/3850 20/18639 0.6 2.90477922077922 0.000139938844158477 0.00240289725824753 GO:0043024 ribosomal small subunit binding 12/3850 20/18639 0.6 2.90477922077922 0.000139938844158477 0.00240289725824753 GO:0000774 adenyl-nucleotide exchange factor activity 10/3850 15/18639 0.666666666666667 3.22753246753247 0.000149709461272105 0.00253728372675451 GO:0000287 magnesium ion binding 71/3850 230/18639 0.308695652173913 1.49448785996612 0.000158138394415741 0.00264577698349412 GO:0140297 DNA-binding transcription factor binding 134/3850 488/18639 0.274590163934426 1.32937300404514 0.000165229354847473 0.00272942162121458 GO:0001098 basal transcription machinery binding 25/3850 60/18639 0.416666666666667 2.01720779220779 0.000175182225947559 0.00277525684446496 GO:0001099 basal RNA polymerase II transcription machinery binding 25/3850 60/18639 0.416666666666667 2.01720779220779 0.000175182225947559 0.00277525684446496 GO:0061749 forked DNA-dependent helicase activity 21/3850 47/18639 0.446808510638298 2.1631334622824 0.000176510588575166 0.00277525684446496 GO:1990518 single-stranded 3'-5' DNA helicase activity 21/3850 47/18639 0.446808510638298 2.1631334622824 0.000176510588575166 0.00277525684446496 GO:0004860 protein kinase inhibitor activity 32/3850 84/18639 0.380952380952381 1.84430426716141 0.000179884836131818 0.00279463941847646 GO:0004601 peroxidase activity 24/3850 57/18639 0.421052631578947 2.03844155844156 0.000193521391997276 0.00297112254772288 GO:0008017 microtubule binding 82/3850 276/18639 0.297101449275362 1.43835686053077 0.000213722427926447 0.00324311358655829 GO:0004518 nuclease activity 65/3850 209/18639 0.311004784688995 1.50566706021251 0.000231851033361816 0.00347776550042724 GO:0009378 four-way junction helicase activity 21/3850 48/18639 0.4375 2.11806818181818 0.000253168788470981 0.00371219403319809 GO:0043138 3'-5' DNA helicase activity 21/3850 48/18639 0.4375 2.11806818181818 0.000253168788470981 0.00371219403319809 GO:0003727 single-stranded RNA binding 33/3850 89/18639 0.370786516853933 1.79508828250401 0.000259813683418544 0.00376130413454149 GO:0003725 double-stranded RNA binding 29/3850 75/18639 0.386666666666667 1.87196883116883 0.000263585137336817 0.00376130413454149 GO:0070182 DNA polymerase binding 12/3850 21/18639 0.571428571428571 2.76645640074212 0.000265164735921699 0.00376130413454149 GO:0051087 protein-folding chaperone binding 45/3850 134/18639 0.335820895522388 1.6258092653615 0.000322059763646785 0.004514210162908 GO:0017070 U6 snRNA binding 10/3850 16/18639 0.625 3.02581168831169 0.000325161498324408 0.004514210162908 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 24/3850 59/18639 0.406779661016949 1.96934184459608 0.000361457883409495 0.00496528987209885 GO:0005344 oxygen carrier activity 9/3850 14/18639 0.642857142857143 3.11226345083488 0.000489997796399632 0.00659223839486102 GO:0008174 mRNA methyltransferase activity 9/3850 14/18639 0.642857142857143 3.11226345083488 0.000489997796399632 0.00659223839486102 GO:0019207 kinase regulator activity 83/3850 287/18639 0.289198606271777 1.40009683696095 0.000504968367365761 0.00672432366747264 GO:0045296 cadherin binding 94/3850 334/18639 0.281437125748503 1.36252119138347 0.000615229165628142 0.00810983900146187 GO:0004549 tRNA-specific ribonuclease activity 10/3850 17/18639 0.588235294117647 2.84782276546982 0.000643503022399145 0.00823305337481259 GO:0048038 quinone binding 10/3850 17/18639 0.588235294117647 2.84782276546982 0.000643503022399145 0.00823305337481259 GO:0070402 NADPH binding 10/3850 17/18639 0.588235294117647 2.84782276546982 0.000643503022399145 0.00823305337481259 GO:0042162 telomeric DNA binding 17/3850 38/18639 0.447368421052632 2.16584415584416 0.000706527135264809 0.00895163020893763 GO:0019210 kinase inhibitor activity 32/3850 90/18639 0.355555555555556 1.72135064935065 0.000749127500671732 0.00937155716640903 GO:0034061 DNA polymerase activity 16/3850 35/18639 0.457142857142857 2.21316512059369 0.000754033335228312 0.00937155716640903 GO:0031369 translation initiation factor binding 15/3850 32/18639 0.46875 2.26935876623377 0.000793495362726477 0.00967767708745844 GO:0051059 NF-kappaB binding 15/3850 32/18639 0.46875 2.26935876623377 0.000793495362726477 0.00967767708745844 GO:0003887 DNA-directed DNA polymerase activity 12/3850 23/18639 0.521739130434783 2.52589497459063 0.000805380011488174 0.00973167513881544 GO:0043175 RNA polymerase core enzyme binding 18/3850 42/18639 0.428571428571429 2.07484230055659 0.000926664828748153 0.0110944734084068 GO:0004129 cytochrome-c oxidase activity 9/3850 15/18639 0.6 2.90477922077922 0.00100043029909092 0.0117618156785013 GO:0055105 ubiquitin-protein transferase inhibitor activity 9/3850 15/18639 0.6 2.90477922077922 0.00100043029909092 0.0117618156785013 GO:0032356 oxidized DNA binding 7/3850 10/18639 0.7 3.38890909090909 0.00105743539201355 0.0123210105944436 GO:0000993 RNA polymerase II complex binding 16/3850 36/18639 0.444444444444444 2.15168831168831 0.0010992519759499 0.0126949011381825 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 23/3850 60/18639 0.383333333333333 1.85583116883117 0.0012619535709643 0.0144460474570914 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 17/3850 40/18639 0.425 2.05755194805195 0.00142702854385225 0.0161936717367582 GO:0140666 annealing activity 8/3850 13/18639 0.615384615384615 2.97926073926074 0.00155047284986419 0.0174428195609721 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 23/3850 61/18639 0.377049180327869 1.82540770704705 0.00163503966395242 0.0182369808671616 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 15/3850 34/18639 0.441176470588235 2.13586707410237 0.00171100075441021 0.0189225083432654 GO:0016675 oxidoreductase activity, acting on a heme group of donors 9/3850 16/18639 0.5625 2.72323051948052 0.00186863304293358 0.0204921522775489 GO:0017056 structural constituent of nuclear pore 12/3850 25/18639 0.48 2.32382337662338 0.0020487609944837 0.0222802758150102 GO:0032404 mismatch repair complex binding 7/3850 11/18639 0.636363636363636 3.08082644628099 0.00238876711264291 0.025551976081959 GO:1990948 ubiquitin ligase inhibitor activity 7/3850 11/18639 0.636363636363636 3.08082644628099 0.00238876711264291 0.025551976081959 GO:0042826 histone deacetylase binding 40/3850 127/18639 0.31496062992126 1.52481848859802 0.00262721162362348 0.0278740745433222 GO:0031072 heat shock protein binding 41/3850 131/18639 0.312977099236641 1.51521562407059 0.00266581490864114 0.0280555520627153 GO:0031491 nucleosome binding 26/3850 74/18639 0.351351351351351 1.70099684099684 0.00272150139946682 0.0284124746104336 GO:0030983 mismatched DNA binding 8/3850 14/18639 0.571428571428571 2.76645640074212 0.00296443958781693 0.0307031243023896 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 18/3850 46/18639 0.391304347826087 1.89442123094297 0.00316776068949832 0.0325506118094119 GO:0004659 prenyltransferase activity 9/3850 17/18639 0.529411764705882 2.56304048892284 0.00324690431603482 0.0331032041595738 GO:0055106 ubiquitin-protein transferase regulator activity 15/3850 36/18639 0.416666666666667 2.01720779220779 0.00337835084940142 0.0341763399881306 GO:0015932 nucleobase-containing compound transmembrane transporter activity 21/3850 57/18639 0.368421052631579 1.78363636363636 0.00353747949152519 0.0355108518187721 GO:0140223 general transcription initiation factor activity 24/3850 68/18639 0.352941176470588 1.70869365928189 0.0036368284220541 0.0362294739754244 GO:0008408 3'-5' exonuclease activity 21/3850 58/18639 0.362068965517241 1.75288401253918 0.00448378704330495 0.0443283491781284 GO:0000995 RNA polymerase III general transcription initiation factor activity 7/3850 12/18639 0.583333333333333 2.82409090909091 0.00471345182795915 0.0459033928021395 GO:0004526 ribonuclease P activity 7/3850 12/18639 0.583333333333333 2.82409090909091 0.00471345182795915 0.0459033928021395 GO:0000400 four-way junction DNA binding 9/3850 18/18639 0.5 2.42064935064935 0.00531332438483671 0.0509844729574405 GO:0070628 proteasome binding 9/3850 18/18639 0.5 2.42064935064935 0.00531332438483671 0.0509844729574405 GO:0016879 ligase activity, forming carbon-nitrogen bonds 18/3850 48/18639 0.375 1.81548701298701 0.00538896263423622 0.051332819253126 GO:0022804 active transmembrane transporter activity 117/3850 457/18639 0.25601750547046 1.23945721674387 0.00569107567208508 0.0538177808121089 GO:0004540 RNA nuclease activity 37/3850 121/18639 0.305785123966942 1.48039712353762 0.00635582292987158 0.0596715749890821 GO:0046875 ephrin receptor binding 12/3850 28/18639 0.428571428571429 2.07484230055659 0.00646878799671977 0.0602983452551378 GO:0043015 gamma-tubulin binding 14/3850 35/18639 0.4 1.93651948051948 0.00703425675867454 0.0648301175288283 GO:0044183 protein folding chaperone 25/3850 75/18639 0.333333333333333 1.61376623376623 0.0070543116391522 0.0648301175288283 GO:0005525 GTP binding 98/3850 378/18639 0.259259259259259 1.25515151515152 0.00739842054191673 0.0662147030700849 GO:0005522 profilin binding 6/3850 10/18639 0.6 2.90477922077922 0.00750940693821653 0.0662147030700849 GO:0008641 ubiquitin-like modifier activating enzyme activity 6/3850 10/18639 0.6 2.90477922077922 0.00750940693821653 0.0662147030700849 GO:0033204 ribonuclease P RNA binding 6/3850 10/18639 0.6 2.90477922077922 0.00750940693821653 0.0662147030700849 GO:0047429 nucleoside triphosphate diphosphatase activity 6/3850 10/18639 0.6 2.90477922077922 0.00750940693821653 0.0662147030700849 GO:0097177 mitochondrial ribosome binding 6/3850 10/18639 0.6 2.90477922077922 0.00750940693821653 0.0662147030700849 GO:0008649 rRNA methyltransferase activity 10/3850 22/18639 0.454545454545455 2.20059031877214 0.00775160423155019 0.067309862935716 GO:0140035 ubiquitin-like protein reader activity 10/3850 22/18639 0.454545454545455 2.20059031877214 0.00775160423155019 0.067309862935716 GO:0016829 lyase activity 56/3850 200/18639 0.28 1.35556363636364 0.00781664540856802 0.067309862935716 GO:0016874 ligase activity 48/3850 167/18639 0.287425149700599 1.39151100396609 0.0078399227327424 0.067309862935716 GO:0140142 nucleocytoplasmic carrier activity 13/3850 32/18639 0.40625 1.9667775974026 0.00797113449841405 0.0679890883688257 GO:0008574 plus-end-directed microtubule motor activity 9/3850 19/18639 0.473684210526316 2.29324675324675 0.00826563841256914 0.0697849490130778 GO:0005338 nucleotide-sugar transmembrane transporter activity 7/3850 13/18639 0.538461538461538 2.60685314685315 0.00840359396906996 0.0697849490130778 GO:0031994 insulin-like growth factor I binding 7/3850 13/18639 0.538461538461538 2.60685314685315 0.00840359396906996 0.0697849490130778 GO:0043560 insulin receptor substrate binding 7/3850 13/18639 0.538461538461538 2.60685314685315 0.00840359396906996 0.0697849490130778 GO:0004519 endonuclease activity 38/3850 127/18639 0.299212598425197 1.44857756416812 0.00844905896097034 0.0697849490130778 GO:0051117 ATPase binding 27/3850 84/18639 0.321428571428571 1.55613172541744 0.00898036301754729 0.0737067530685485 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 16/3850 43/18639 0.372093023255814 1.80141347025068 0.00920083333954137 0.0750442969256343 GO:0050661 NADP binding 19/3850 54/18639 0.351851851851852 1.70341991341991 0.00943397103396404 0.0764679018591495 GO:0019838 growth factor binding 40/3850 136/18639 0.294117647058824 1.42391138273491 0.00957178147463262 0.0771060174345406 GO:0070006 metalloaminopeptidase activity 11/3850 26/18639 0.423076923076923 2.04824175824176 0.0100852947243605 0.0807442307686527 GO:0004532 RNA exonuclease activity 15/3850 40/18639 0.375 1.81548701298701 0.0106193411718837 0.0845014648128552 GO:0016830 carbon-carbon lyase activity 18/3850 51/18639 0.352941176470588 1.70869365928189 0.0109552497324628 0.0866460660658421 GO:0005158 insulin receptor binding 10/3850 23/18639 0.434782608695652 2.10491247882552 0.0112137142748383 0.0876281265189457 GO:0140102 catalytic activity, acting on a rRNA 10/3850 23/18639 0.434782608695652 2.10491247882552 0.0112137142748383 0.0876281265189457 GO:0008187 poly-pyrimidine tract binding 12/3850 30/18639 0.4 1.93651948051948 0.0122216179417256 0.0945215865927512 GO:0000339 RNA cap binding 9/3850 20/18639 0.45 2.17858441558442 0.0123131568741515 0.0945215865927512 GO:0140664 ATP-dependent DNA damage sensor activity 9/3850 20/18639 0.45 2.17858441558442 0.0123131568741515 0.0945215865927512 GO:0016209 antioxidant activity 27/3850 86/18639 0.313953488372093 1.51994261552401 0.0125103278102714 0.0954735543415451 GO:0140318 protein transporter activity 15/3850 41/18639 0.365853658536585 1.77120684193855 0.013613825760724 0.101821131549834 GO:0008526 phosphatidylinositol transfer activity 6/3850 11/18639 0.545454545454545 2.64070838252656 0.0136541747289049 0.101821131549834 GO:0048407 platelet-derived growth factor binding 6/3850 11/18639 0.545454545454545 2.64070838252656 0.0136541747289049 0.101821131549834 GO:0070990 snRNP binding 6/3850 11/18639 0.545454545454545 2.64070838252656 0.0136541747289049 0.101821131549834 GO:0015035 protein-disulfide reductase activity 13/3850 34/18639 0.382352941176471 1.85108479755539 0.0141246371116709 0.104730974038242 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 20/3850 60/18639 0.333333333333333 1.61376623376623 0.0149639973335648 0.110327776950859 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 14/3850 38/18639 0.368421052631579 1.78363636363636 0.0157886677780701 0.115376464506643 GO:0060590 ATPase regulator activity 17/3850 49/18639 0.346938775510204 1.67963424330771 0.0158255840204514 0.115376464506643 GO:0030145 manganese ion binding 22/3850 68/18639 0.323529411764706 1.5663025210084 0.0159380748216081 0.115551042456659 GO:0032182 ubiquitin-like protein binding 35/3850 120/18639 0.291666666666667 1.41204545454545 0.016661332876497 0.119077870220596 GO:0016251 RNA polymerase II general transcription initiation factor activity 18/3850 53/18639 0.339622641509434 1.64421465327126 0.0166982760539226 0.119077870220596 GO:1901505 carbohydrate derivative transmembrane transporter activity 18/3850 53/18639 0.339622641509434 1.64421465327126 0.0166982760539226 0.119077870220596 GO:0016407 acetyltransferase activity 29/3850 96/18639 0.302083333333333 1.46247564935065 0.0171669326767144 0.121494476403601 GO:0016859 cis-trans isomerase activity 15/3850 42/18639 0.357142857142857 1.72903525046382 0.0172233548924646 0.121494476403601 GO:0019200 carbohydrate kinase activity 9/3850 21/18639 0.428571428571429 2.07484230055659 0.0176673853347978 0.123293785357813 GO:0140312 cargo adaptor activity 9/3850 21/18639 0.428571428571429 2.07484230055659 0.0176673853347978 0.123293785357813 GO:0030291 protein serine/threonine kinase inhibitor activity 16/3850 46/18639 0.347826086956522 1.68392998306042 0.0184454849525254 0.128039137569392 GO:0016866 intramolecular transferase activity 11/3850 28/18639 0.392857142857143 1.9019387755102 0.0187070025018823 0.12848756981556 GO:0097718 disordered domain specific binding 11/3850 28/18639 0.392857142857143 1.9019387755102 0.0187070025018823 0.12848756981556 GO:0002039 p53 binding 22/3850 69/18639 0.318840579710145 1.54360248447205 0.0189468644267611 0.129328718595399 GO:0019001 guanyl nucleotide binding 100/3850 400/18639 0.25 1.21032467532468 0.0191791036737769 0.129328718595399 GO:0032561 guanyl ribonucleotide binding 100/3850 400/18639 0.25 1.21032467532468 0.0191791036737769 0.129328718595399 GO:0004521 RNA endonuclease activity 23/3850 73/18639 0.315068493150685 1.52534068671055 0.0192601358539824 0.129328718595399 GO:0015605 organophosphate ester transmembrane transporter activity 17/3850 50/18639 0.34 1.64604155844156 0.0194745560118833 0.129328718595399 GO:0003746 translation elongation factor activity 8/3850 18/18639 0.444444444444444 2.15168831168831 0.0196222883386122 0.129328718595399 GO:0008409 5'-3' exonuclease activity 8/3850 18/18639 0.444444444444444 2.15168831168831 0.0196222883386122 0.129328718595399 GO:0035615 clathrin adaptor activity 8/3850 18/18639 0.444444444444444 2.15168831168831 0.0196222883386122 0.129328718595399 GO:0070717 poly-purine tract binding 12/3850 32/18639 0.375 1.81548701298701 0.0212457095438262 0.139324879169312 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 35/3850 122/18639 0.286885245901639 1.38889716840537 0.0213757095600062 0.13947650487904 GO:0000340 RNA 7-methylguanosine cap binding 6/3850 12/18639 0.5 2.42064935064935 0.0225948976298506 0.144425661271373 GO:0005049 nuclear export signal receptor activity 6/3850 12/18639 0.5 2.42064935064935 0.0225948976298506 0.144425661271373 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 6/3850 12/18639 0.5 2.42064935064935 0.0225948976298506 0.144425661271373 GO:0097371 MDM2/MDM4 family protein binding 6/3850 12/18639 0.5 2.42064935064935 0.0225948976298506 0.144425661271373 GO:0061733 protein-lysine-acetyltransferase activity 16/3850 47/18639 0.340425531914894 1.64810168554849 0.0227373871306363 0.144425661271373 GO:0004857 enzyme inhibitor activity 103/3850 416/18639 0.247596153846154 1.19868693806194 0.02288251163913 0.144425661271373 GO:0050660 flavin adenine dinucleotide binding 26/3850 86/18639 0.302325581395349 1.46364844457868 0.0229088979947695 0.144425661271373 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 13/3850 36/18639 0.361111111111111 1.74824675324675 0.0233751744845395 0.14526001286821 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 13/3850 36/18639 0.361111111111111 1.74824675324675 0.0233751744845395 0.14526001286821 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 13/3850 36/18639 0.361111111111111 1.74824675324675 0.0233751744845395 0.14526001286821 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 9/3850 22/18639 0.409090909090909 1.98053128689492 0.0245321568678153 0.151011626002354 GO:0140517 protein-RNA adaptor activity 9/3850 22/18639 0.409090909090909 1.98053128689492 0.0245321568678153 0.151011626002354 GO:0015036 disulfide oxidoreductase activity 14/3850 40/18639 0.35 1.69445454545455 0.0251382199174105 0.153515707761144 GO:0036002 pre-mRNA binding 19/3850 59/18639 0.322033898305085 1.55906229363856 0.0251742233416741 0.153515707761144 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 37/3850 132/18639 0.28030303030303 1.35703069657615 0.0261662062810647 0.158822786961811 GO:0016835 carbon-oxygen lyase activity 24/3850 79/18639 0.30379746835443 1.47077428900214 0.026497174350084 0.160087095031757 GO:0005520 insulin-like growth factor binding 8/3850 19/18639 0.421052631578947 2.03844155844156 0.0278816701030072 0.166906327910204 GO:0140036 ubiquitin-modified protein reader activity 8/3850 19/18639 0.421052631578947 2.03844155844156 0.0278816701030072 0.166906327910204 GO:0004529 DNA exonuclease activity 10/3850 26/18639 0.384615384615385 1.86203796203796 0.0285714829659331 0.16948084213883 GO:0008143 poly(A) binding 10/3850 26/18639 0.384615384615385 1.86203796203796 0.0285714829659331 0.16948084213883 GO:0004536 DNA nuclease activity 20/3850 64/18639 0.3125 1.51290584415584 0.0302845485348239 0.178829573927354 GO:0016877 ligase activity, forming carbon-sulfur bonds 14/3850 41/18639 0.341463414634146 1.65312638580931 0.0311138317023589 0.18289887554765 GO:0043023 ribosomal large subunit binding 7/3850 16/18639 0.4375 2.11806818181818 0.0313900306791242 0.183695022584113 GO:0035925 mRNA 3'-UTR AU-rich region binding 11/3850 30/18639 0.366666666666667 1.77514285714286 0.0318346312240809 0.18546515065815 GO:0034212 protein N-acetyltransferase activity 17/3850 53/18639 0.320754716981132 1.55286939475619 0.0343103779455154 0.196365057212491 GO:0140296 general transcription initiation factor binding 17/3850 53/18639 0.320754716981132 1.55286939475619 0.0343103779455154 0.196365057212491 GO:0019825 oxygen binding 12/3850 34/18639 0.352941176470588 1.70869365928189 0.0344348702359004 0.196365057212491 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 6/3850 13/18639 0.461538461538462 2.23444555444555 0.0347588721962341 0.196365057212491 GO:0005542 folic acid binding 6/3850 13/18639 0.461538461538462 2.23444555444555 0.0347588721962341 0.196365057212491 GO:0009982 pseudouridine synthase activity 6/3850 13/18639 0.461538461538462 2.23444555444555 0.0347588721962341 0.196365057212491 GO:0097157 pre-mRNA intronic binding 6/3850 13/18639 0.461538461538462 2.23444555444555 0.0347588721962341 0.196365057212491 GO:0004674 protein serine/threonine kinase activity 105/3850 433/18639 0.242494226327945 1.17398698299391 0.0370673244009314 0.20441765060974 GO:0001094 TFIID-class transcription factor complex binding 5/3850 10/18639 0.5 2.42064935064935 0.037280766931125 0.20441765060974 GO:0005345 purine nucleobase transmembrane transporter activity 5/3850 10/18639 0.5 2.42064935064935 0.037280766931125 0.20441765060974 GO:0016427 tRNA (cytidine) methyltransferase activity 5/3850 10/18639 0.5 2.42064935064935 0.037280766931125 0.20441765060974 GO:0050815 phosphoserine residue binding 5/3850 10/18639 0.5 2.42064935064935 0.037280766931125 0.20441765060974 GO:0051880 G-quadruplex DNA binding 5/3850 10/18639 0.5 2.42064935064935 0.037280766931125 0.20441765060974 GO:0098505 G-rich strand telomeric DNA binding 5/3850 10/18639 0.5 2.42064935064935 0.037280766931125 0.20441765060974 GO:0004402 histone acetyltransferase activity 14/3850 42/18639 0.333333333333333 1.61376623376623 0.0380590701073061 0.206946193708477 GO:0019894 kinesin binding 14/3850 42/18639 0.333333333333333 1.61376623376623 0.0380590701073061 0.206946193708477 GO:0016004 phospholipase activator activity 8/3850 20/18639 0.4 1.93651948051948 0.0382606789222444 0.207084273706606 GO:0008170 N-methyltransferase activity 28/3850 98/18639 0.285714285714286 1.38322820037106 0.0384018346643668 0.207084273706606 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 86/3850 349/18639 0.246418338108883 1.19298478026272 0.038767612982808 0.208196440092858 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 17/3850 54/18639 0.314814814814815 1.52411255411255 0.0407335979316622 0.216968756329874 GO:0140463 chromatin-protein adaptor activity 17/3850 54/18639 0.314814814814815 1.52411255411255 0.0407335979316622 0.216968756329874 GO:0000175 3'-5'-RNA exonuclease activity 12/3850 35/18639 0.342857142857143 1.65987384044527 0.0428455465397132 0.226235436637672 GO:0001091 RNA polymerase II general transcription initiation factor binding 9/3850 24/18639 0.375 1.81548701298701 0.0435134824490849 0.226235436637672 GO:0005540 hyaluronic acid binding 9/3850 24/18639 0.375 1.81548701298701 0.0435134824490849 0.226235436637672 GO:0060229 lipase activator activity 9/3850 24/18639 0.375 1.81548701298701 0.0435134824490849 0.226235436637672 GO:0070300 phosphatidic acid binding 9/3850 24/18639 0.375 1.81548701298701 0.0435134824490849 0.226235436637672 GO:0140612 DNA damage sensor activity 9/3850 24/18639 0.375 1.81548701298701 0.0435134824490849 0.226235436637672 GO:0032977 membrane insertase activity 7/3850 17/18639 0.411764705882353 1.99347593582888 0.0440791279919905 0.228266912815665 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 13/3850 39/18639 0.333333333333333 1.61376623376623 0.0446898937308256 0.230515064500899 GO:0005201 extracellular matrix structural constituent 44/3850 168/18639 0.261904761904762 1.26795918367347 0.0489580576488927 0.25153647729057 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 58/3850 229/18639 0.253275109170306 1.22618045709749 0.0494733969447433 0.251773427438467 GO:0019208 phosphatase regulator activity 32/3850 117/18639 0.273504273504274 1.32411588411588 0.0499092656020177 0.251773427438467 GO:0008474 palmitoyl-(protein) hydrolase activity 6/3850 14/18639 0.428571428571429 2.07484230055659 0.0504459650806674 0.251773427438467 GO:0016530 metallochaperone activity 6/3850 14/18639 0.428571428571429 2.07484230055659 0.0504459650806674 0.251773427438467 GO:0032036 myosin heavy chain binding 6/3850 14/18639 0.428571428571429 2.07484230055659 0.0504459650806674 0.251773427438467 GO:0098599 palmitoyl hydrolase activity 6/3850 14/18639 0.428571428571429 2.07484230055659 0.0504459650806674 0.251773427438467 GO:0098847 sequence-specific single stranded DNA binding 6/3850 14/18639 0.428571428571429 2.07484230055659 0.0504459650806674 0.251773427438467 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 8/3850 21/18639 0.380952380952381 1.84430426716141 0.0509334749760577 0.251773427438467 GO:0072542 protein phosphatase activator activity 8/3850 21/18639 0.380952380952381 1.84430426716141 0.0509334749760577 0.251773427438467 GO:1904047 S-adenosyl-L-methionine binding 8/3850 21/18639 0.380952380952381 1.84430426716141 0.0509334749760577 0.251773427438467 GO:0004177 aminopeptidase activity 13/3850 40/18639 0.325 1.57342207792208 0.0541036626039514 0.266435017728893 GO:1990841 promoter-specific chromatin binding 20/3850 68/18639 0.294117647058824 1.42391138273491 0.0551050688337801 0.270346296346177 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 9/3850 25/18639 0.36 1.74286753246753 0.055917772883698 0.272286170198604 GO:0019211 phosphatase activator activity 9/3850 25/18639 0.36 1.74286753246753 0.055917772883698 0.272286170198604 GO:0051219 phosphoprotein binding 26/3850 93/18639 0.279569892473118 1.35348135735232 0.0568318025748832 0.272327178992794 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5/3850 11/18639 0.454545454545455 2.20059031877214 0.0569695937663086 0.272327178992794 GO:0015205 nucleobase transmembrane transporter activity 5/3850 11/18639 0.454545454545455 2.20059031877214 0.0569695937663086 0.272327178992794 GO:0015217 ADP transmembrane transporter activity 5/3850 11/18639 0.454545454545455 2.20059031877214 0.0569695937663086 0.272327178992794 GO:0034511 U3 snoRNA binding 5/3850 11/18639 0.454545454545455 2.20059031877214 0.0569695937663086 0.272327178992794 GO:0019903 protein phosphatase binding 38/3850 144/18639 0.263888888888889 1.27756493506493 0.0575334613221996 0.274018857757192 GO:0003785 actin monomer binding 10/3850 29/18639 0.344827586206897 1.66941334527541 0.0594954495225553 0.280987565657576 GO:0003774 cytoskeletal motor activity 40/3850 153/18639 0.261437908496732 1.26569900687548 0.0595760015689208 0.280987565657576 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 7/3850 18/18639 0.388888888888889 1.88272727272727 0.0596425714077767 0.280987565657576 GO:0043539 protein serine/threonine kinase activator activity 21/3850 73/18639 0.287671232876712 1.39270236612702 0.0621636224943314 0.291811249478786 GO:0017124 SH3 domain binding 31/3850 115/18639 0.269565217391304 1.30504573687182 0.062803738181063 0.293759420524327 GO:0008080 N-acetyltransferase activity 20/3850 69/18639 0.289855072463768 1.40327498588368 0.0630667174400851 0.293935950926111 GO:0160215 deacylase activity 19/3850 65/18639 0.292307692307692 1.41514885114885 0.0638752726482855 0.296337382199925 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 34/3850 128/18639 0.265625 1.28596996753247 0.064036123969639 0.296337382199925 GO:0016504 peptidase activator activity 17/3850 57/18639 0.298245614035088 1.4438961038961 0.0651013196899259 0.300202198570153 GO:0016860 intramolecular oxidoreductase activity 16/3850 53/18639 0.30188679245283 1.46152413624112 0.0654480844302633 0.300408140864776 GO:0016881 acid-amino acid ligase activity 8/3850 22/18639 0.363636363636364 1.76047225501771 0.0660199424664821 0.300408140864776 GO:0061133 endopeptidase activator activity 8/3850 22/18639 0.363636363636364 1.76047225501771 0.0660199424664821 0.300408140864776 GO:0016791 phosphatase activity 67/3850 273/18639 0.245421245421245 1.18815755672899 0.0660667712093416 0.300408140864776 GO:0010181 FMN binding 6/3850 15/18639 0.4 1.93651948051948 0.0698117689819191 0.316334578199321 GO:0051721 protein phosphatase 2A binding 10/3850 30/18639 0.333333333333333 1.61376623376623 0.0733258586717925 0.331108116147713 GO:0016831 carboxy-lyase activity 11/3850 34/18639 0.323529411764706 1.5663025210084 0.0751956497702675 0.337217604639859 GO:0030332 cyclin binding 11/3850 34/18639 0.323529411764706 1.5663025210084 0.0751956497702675 0.337217604639859 GO:0051879 Hsp90 protein binding 13/3850 42/18639 0.30952380952381 1.49849721706865 0.0767547455362769 0.342957591950886 GO:0043130 ubiquitin binding 27/3850 100/18639 0.27 1.30715064935065 0.0770012064686664 0.342957591950886 GO:0106310 protein serine kinase activity 86/3850 361/18639 0.238227146814404 1.15332877648667 0.0773013439933566 0.343123312623573 GO:0003756 protein disulfide isomerase activity 7/3850 19/18639 0.368421052631579 1.78363636363636 0.0781697638355589 0.343473204732001 GO:0008301 DNA binding, bending 7/3850 19/18639 0.368421052631579 1.78363636363636 0.0781697638355589 0.343473204732001 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 7/3850 19/18639 0.368421052631579 1.78363636363636 0.0781697638355589 0.343473204732001 GO:0052689 carboxylic ester hydrolase activity 25/3850 92/18639 0.271739130434783 1.31557029926595 0.0810509043334244 0.346538916400938 GO:0003995 acyl-CoA dehydrogenase activity 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:0005095 GTPase inhibitor activity 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:0015368 calcium:monoatomic cation antiporter activity 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:0016273 arginine N-methyltransferase activity 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:0016274 protein-arginine N-methyltransferase activity 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:0036009 protein-glutamine N-methyltransferase activity 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:0043047 single-stranded telomeric DNA binding 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:1990247 N6-methyladenosine-containing RNA reader activity 5/3850 12/18639 0.416666666666667 2.01720779220779 0.0815229481494928 0.346538916400938 GO:0004602 glutathione peroxidase activity 8/3850 23/18639 0.347826086956522 1.68392998306042 0.0835804382777025 0.351846683717425 GO:0008171 O-methyltransferase activity 8/3850 23/18639 0.347826086956522 1.68392998306042 0.0835804382777025 0.351846683717425 GO:0017134 fibroblast growth factor binding 8/3850 23/18639 0.347826086956522 1.68392998306042 0.0835804382777025 0.351846683717425 GO:0008266 poly(U) RNA binding 9/3850 27/18639 0.333333333333333 1.61376623376623 0.0869916920572111 0.365029447378329 GO:0030544 Hsp70 protein binding 15/3850 51/18639 0.294117647058824 1.42391138273491 0.0884650387885376 0.370022037240518 GO:0072349 modified amino acid transmembrane transporter activity 10/3850 31/18639 0.32258064516129 1.56170925848345 0.0890065441101045 0.371097572088455 GO:0010485 histone H4 acetyltransferase activity 11/3850 35/18639 0.314285714285714 1.52155102040816 0.0900227804176046 0.374139262563612 GO:0005159 insulin-like growth factor receptor binding 6/3850 16/18639 0.375 1.81548701298701 0.0928648119635959 0.379901503487438 GO:0008296 3'-5'-DNA exonuclease activity 6/3850 16/18639 0.375 1.81548701298701 0.0928648119635959 0.379901503487438 GO:0015923 mannosidase activity 6/3850 16/18639 0.375 1.81548701298701 0.0928648119635959 0.379901503487438 GO:0070411 I-SMAD binding 6/3850 16/18639 0.375 1.81548701298701 0.0928648119635959 0.379901503487438 GO:0097027 ubiquitin-protein transferase activator activity 6/3850 16/18639 0.375 1.81548701298701 0.0928648119635959 0.379901503487438 GO:0003777 microtubule motor activity 19/3850 68/18639 0.279411764705882 1.35271581359817 0.0936996332471684 0.382118816836109 GO:0016410 N-acyltransferase activity 25/3850 94/18639 0.265957446808511 1.28757944183476 0.0994809741447465 0.402648138640958 GO:0052745 inositol phosphate phosphatase activity 7/3850 20/18639 0.35 1.69445454545455 0.0996592710965744 0.402648138640958 GO:0061608 nuclear import signal receptor activity 7/3850 20/18639 0.35 1.69445454545455 0.0996592710965744 0.402648138640958 GO:0005080 protein kinase C binding 15/3850 52/18639 0.288461538461538 1.39652847152847 0.101607072583116 0.407991476064512 GO:0030159 signaling receptor complex adaptor activity 15/3850 52/18639 0.288461538461538 1.39652847152847 0.101607072583116 0.407991476064512 GO:0035591 signaling adaptor activity 33/3850 129/18639 0.255813953488372 1.23847176079734 0.102685762139152 0.411058035557034 GO:0016790 thiolester hydrolase activity 13/3850 44/18639 0.295454545454545 1.43038370720189 0.104714376192367 0.414736385668257 GO:0030020 extracellular matrix structural constituent conferring tensile strength 13/3850 44/18639 0.295454545454545 1.43038370720189 0.104714376192367 0.414736385668257 GO:0051015 actin filament binding 51/3850 209/18639 0.244019138755981 1.18136953955136 0.105457017728162 0.414736385668257 GO:0050997 quaternary ammonium group binding 12/3850 40/18639 0.3 1.45238961038961 0.105829284618796 0.414736385668257 GO:0061791 GTPase motor activity 12/3850 40/18639 0.3 1.45238961038961 0.105829284618796 0.414736385668257 GO:0140662 ATP-dependent protein folding chaperone 12/3850 40/18639 0.3 1.45238961038961 0.105829284618796 0.414736385668257 GO:1990606 membrane scission GTPase motor activity 12/3850 40/18639 0.3 1.45238961038961 0.105829284618796 0.414736385668257 GO:0022884 macromolecule transmembrane transporter activity 10/3850 32/18639 0.3125 1.51290584415584 0.106542362622042 0.416280788089115 GO:0042578 phosphoric ester hydrolase activity 85/3850 363/18639 0.234159779614325 1.13363743694322 0.107427257247412 0.418485285695142 GO:0003964 RNA-directed DNA polymerase activity 5/3850 13/18639 0.384615384615385 1.86203796203796 0.11075049562028 0.422600575393172 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 5/3850 13/18639 0.384615384615385 1.86203796203796 0.11075049562028 0.422600575393172 GO:0046975 histone H3K36 methyltransferase activity 5/3850 13/18639 0.384615384615385 1.86203796203796 0.11075049562028 0.422600575393172 GO:0051011 microtubule minus-end binding 5/3850 13/18639 0.384615384615385 1.86203796203796 0.11075049562028 0.422600575393172 GO:0070700 BMP receptor binding 5/3850 13/18639 0.384615384615385 1.86203796203796 0.11075049562028 0.422600575393172 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/3850 13/18639 0.384615384615385 1.86203796203796 0.11075049562028 0.422600575393172 GO:0140852 histone ubiquitin ligase activity 5/3850 13/18639 0.384615384615385 1.86203796203796 0.11075049562028 0.422600575393172 GO:0035173 histone kinase activity 84/3850 360/18639 0.233333333333333 1.12963636363636 0.115722612413798 0.440285741107889 GO:0004721 phosphoprotein phosphatase activity 43/3850 175/18639 0.245714285714286 1.18957625231911 0.11793054202702 0.446748184744748 GO:0035402 histone H3T11 kinase activity 59/3850 247/18639 0.238866396761134 1.15642357642358 0.119325818200009 0.446748184744748 GO:0035403 histone H3T6 kinase activity 59/3850 247/18639 0.238866396761134 1.15642357642358 0.119325818200009 0.446748184744748 GO:0004029 aldehyde dehydrogenase (NAD+) activity 6/3850 17/18639 0.352941176470588 1.70869365928189 0.119475185039017 0.446748184744748 GO:0016018 cyclosporin A binding 6/3850 17/18639 0.352941176470588 1.70869365928189 0.119475185039017 0.446748184744748 GO:0032183 SUMO binding 6/3850 17/18639 0.352941176470588 1.70869365928189 0.119475185039017 0.446748184744748 GO:0035613 RNA stem-loop binding 7/3850 21/18639 0.333333333333333 1.61376623376623 0.124022169156833 0.454654357479298 GO:0051010 microtubule plus-end binding 7/3850 21/18639 0.333333333333333 1.61376623376623 0.124022169156833 0.454654357479298 GO:0140996 histone H3 kinase activity 83/3850 357/18639 0.23249299719888 1.12556804539998 0.124538864527437 0.454654357479298 GO:0000030 mannosyltransferase activity 8/3850 25/18639 0.32 1.54921558441558 0.126059160101806 0.454654357479298 GO:0015662 P-type ion transporter activity 8/3850 25/18639 0.32 1.54921558441558 0.126059160101806 0.454654357479298 GO:0047617 fatty acyl-CoA hydrolase activity 8/3850 25/18639 0.32 1.54921558441558 0.126059160101806 0.454654357479298 GO:0140358 P-type transmembrane transporter activity 8/3850 25/18639 0.32 1.54921558441558 0.126059160101806 0.454654357479298 GO:0002020 protease binding 34/3850 136/18639 0.25 1.21032467532468 0.126222617260763 0.454654357479298 GO:0019902 phosphatase binding 46/3850 190/18639 0.242105263157895 1.1721038961039 0.130775221452628 0.454654357479298 GO:0003925 G protein activity 15/3850 54/18639 0.277777777777778 1.34480519480519 0.131275039446323 0.454654357479298 GO:0000182 rDNA binding 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0003680 minor groove of adenine-thymine-rich DNA binding 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0005337 nucleoside transmembrane transporter activity 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0008239 dipeptidyl-peptidase activity 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0015924 mannosyl-oligosaccharide mannosidase activity 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0016783 sulfurtransferase activity 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0043295 glutathione binding 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0099122 RNA polymerase II C-terminal domain binding 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0140135 mechanosensitive monoatomic cation channel activity 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0140940 histone H2A methyltransferase activity 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:1990259 histone H2AQ104 methyltransferase activity 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:1990757 ubiquitin ligase activator activity 4/3850 10/18639 0.4 1.93651948051948 0.132648201957811 0.454654357479298 GO:0003924 GTPase activity 77/3850 331/18639 0.232628398791541 1.12622356495468 0.133266262651185 0.454654357479298 GO:0141003 histone H2AX kinase activity 82/3850 354/18639 0.231638418079096 1.12143077261721 0.133895637690221 0.454654357479298 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 18/3850 67/18639 0.26865671641791 1.3006474122892 0.135180021731194 0.454654357479298 GO:0050840 extracellular matrix binding 18/3850 67/18639 0.26865671641791 1.3006474122892 0.135180021731194 0.454654357479298 GO:0004676 3-phosphoinositide-dependent protein kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0004711 ribosomal protein S6 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0035175 histone H3S10 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0035979 histone H2AXS139 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0044022 histone H3S28 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0044023 histone H4S1 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0044024 histone H2AS1 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0044025 histone H2BS14 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0072354 histone H3T3 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0072371 histone H2AS121 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0072518 Rho-dependent protein serine/threonine kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0140823 histone H2BS36 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0140855 histone H3S57 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0140995 histone H2A kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0140997 histone H4 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0140998 histone H2B kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:1990244 histone H2AT120 kinase activity 58/3850 245/18639 0.236734693877551 1.14610336602173 0.137267292602945 0.454654357479298 GO:0035198 miRNA binding 12/3850 42/18639 0.285714285714286 1.38322820037106 0.141240816417907 0.466505832521868 GO:0020037 heme binding 35/3850 142/18639 0.246478873239437 1.19327784891165 0.14156039055836 0.466505832521868 GO:0045309 protein phosphorylated amino acid binding 16/3850 59/18639 0.271186440677966 1.31289456306405 0.143473890190524 0.470213178527323 GO:0005347 ATP transmembrane transporter activity 5/3850 14/18639 0.357142857142857 1.72903525046382 0.144253012586731 0.470213178527323 GO:0061665 SUMO ligase activity 5/3850 14/18639 0.357142857142857 1.72903525046382 0.144253012586731 0.470213178527323 GO:1990825 sequence-specific mRNA binding 5/3850 14/18639 0.357142857142857 1.72903525046382 0.144253012586731 0.470213178527323 GO:0004677 DNA-dependent protein kinase activity 58/3850 246/18639 0.235772357723577 1.14144440924929 0.144847277983129 0.470213178527323 GO:0140857 histone H3T45 kinase activity 58/3850 246/18639 0.235772357723577 1.14144440924929 0.144847277983129 0.470213178527323 GO:0005518 collagen binding 19/3850 72/18639 0.263888888888889 1.27756493506493 0.145394959524356 0.470819906152072 GO:0019888 protein phosphatase regulator activity 27/3850 107/18639 0.252336448598131 1.22163612088846 0.146422353673794 0.472973196891835 GO:0008525 phosphatidylcholine transporter activity 6/3850 18/18639 0.333333333333333 1.61376623376623 0.149391491854637 0.477414738024432 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 6/3850 18/18639 0.333333333333333 1.61376623376623 0.149391491854637 0.477414738024432 GO:0070064 proline-rich region binding 6/3850 18/18639 0.333333333333333 1.61376623376623 0.149391491854637 0.477414738024432 GO:0098641 cadherin binding involved in cell-cell adhesion 6/3850 18/18639 0.333333333333333 1.61376623376623 0.149391491854637 0.477414738024432 GO:0016289 acyl-CoA hydrolase activity 8/3850 26/18639 0.307692307692308 1.48963036963037 0.150798688819399 0.477414738024432 GO:0050750 low-density lipoprotein particle receptor binding 8/3850 26/18639 0.307692307692308 1.48963036963037 0.150798688819399 0.477414738024432 GO:0004407 histone deacetylase activity 7/3850 22/18639 0.318181818181818 1.5404132231405 0.151089874945663 0.477414738024432 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/3850 22/18639 0.318181818181818 1.5404132231405 0.151089874945663 0.477414738024432 GO:0033558 protein lysine deacetylase activity 7/3850 22/18639 0.318181818181818 1.5404132231405 0.151089874945663 0.477414738024432 GO:0140938 histone H3 methyltransferase activity 13/3850 47/18639 0.276595744680851 1.33908261950815 0.1565854077444 0.493584437455173 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 57/3850 243/18639 0.234567901234568 1.13561327561328 0.157173155401359 0.494243295900658 GO:0004679 AMP-activated protein kinase activity 58/3850 248/18639 0.233870967741935 1.1322392124005 0.160761634498516 0.504010096886378 GO:0048156 tau protein binding 12/3850 43/18639 0.27906976744186 1.35106010268801 0.161051502223463 0.504010096886378 GO:0008276 protein methyltransferase activity 24/3850 95/18639 0.252631578947368 1.22306493506494 0.161900611713963 0.505455259059142 GO:0016776 phosphotransferase activity, phosphate group as acceptor 11/3850 39/18639 0.282051282051282 1.36549450549451 0.165494971508179 0.515443765675831 GO:0016229 steroid dehydrogenase activity 10/3850 35/18639 0.285714285714286 1.38322820037106 0.169838305837165 0.527711878851191 GO:0004523 RNA-DNA hybrid ribonuclease activity 4/3850 11/18639 0.363636363636364 1.76047225501771 0.175893120924384 0.536557816315557 GO:0005536 D-glucose binding 4/3850 11/18639 0.363636363636364 1.76047225501771 0.175893120924384 0.536557816315557 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4/3850 11/18639 0.363636363636364 1.76047225501771 0.175893120924384 0.536557816315557 GO:0047676 arachidonate-CoA ligase activity 4/3850 11/18639 0.363636363636364 1.76047225501771 0.175893120924384 0.536557816315557 GO:0050786 RAGE receptor binding 4/3850 11/18639 0.363636363636364 1.76047225501771 0.175893120924384 0.536557816315557 GO:0140031 phosphorylation-dependent protein binding 4/3850 11/18639 0.363636363636364 1.76047225501771 0.175893120924384 0.536557816315557 GO:1900750 oligopeptide binding 4/3850 11/18639 0.363636363636364 1.76047225501771 0.175893120924384 0.536557816315557 GO:0035064 methylated histone binding 19/3850 74/18639 0.256756756756757 1.24303615303615 0.176250105734964 0.536557816315557 GO:0140693 molecular condensate scaffold activity 13/3850 48/18639 0.270833333333333 1.31118506493506 0.176385672949712 0.536557816315557 GO:0004364 glutathione transferase activity 8/3850 27/18639 0.296296296296296 1.43445887445887 0.177664792719268 0.536695728006122 GO:0008320 protein transmembrane transporter activity 8/3850 27/18639 0.296296296296296 1.43445887445887 0.177664792719268 0.536695728006122 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 8/3850 27/18639 0.296296296296296 1.43445887445887 0.177664792719268 0.536695728006122 GO:0004559 alpha-mannosidase activity 5/3850 15/18639 0.333333333333333 1.61376623376623 0.181473634389137 0.538996022703935 GO:0008252 nucleotidase activity 5/3850 15/18639 0.333333333333333 1.61376623376623 0.181473634389137 0.538996022703935 GO:0016846 carbon-sulfur lyase activity 5/3850 15/18639 0.333333333333333 1.61376623376623 0.181473634389137 0.538996022703935 GO:0031386 protein tag activity 5/3850 15/18639 0.333333333333333 1.61376623376623 0.181473634389137 0.538996022703935 GO:0050700 CARD domain binding 5/3850 15/18639 0.333333333333333 1.61376623376623 0.181473634389137 0.538996022703935 GO:0141047 molecular tag activity 5/3850 15/18639 0.333333333333333 1.61376623376623 0.181473634389137 0.538996022703935 GO:0019205 nucleobase-containing compound kinase activity 12/3850 44/18639 0.272727272727273 1.32035419126328 0.182177924485124 0.538996022703935 GO:0005346 purine ribonucleotide transmembrane transporter activity 6/3850 19/18639 0.315789473684211 1.52883116883117 0.182263058632673 0.538996022703935 GO:0046527 glucosyltransferase activity 6/3850 19/18639 0.315789473684211 1.52883116883117 0.182263058632673 0.538996022703935 GO:0097110 scaffold protein binding 18/3850 70/18639 0.257142857142857 1.24490538033395 0.18255650730662 0.538996022703935 GO:0140030 modification-dependent protein binding 41/3850 173/18639 0.236994219653179 1.14735980782224 0.183283499492548 0.539920918369697 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 11/3850 40/18639 0.275 1.33135714285714 0.188126783776566 0.552805785665072 GO:0004197 cysteine-type endopeptidase activity 22/3850 88/18639 0.25 1.21032467532468 0.188504654881959 0.552805785665072 GO:0019789 SUMO transferase activity 8/3850 28/18639 0.285714285714286 1.38322820037106 0.206447120180661 0.602714746836157 GO:0051537 2 iron, 2 sulfur cluster binding 8/3850 28/18639 0.285714285714286 1.38322820037106 0.206447120180661 0.602714746836157 GO:0140034 methylation-dependent protein binding 19/3850 76/18639 0.25 1.21032467532468 0.210185344741451 0.612258649302665 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 11/3850 41/18639 0.268292682926829 1.2988850174216 0.212073988757577 0.613049169030047 GO:0043998 histone H2A acetyltransferase activity 7/3850 24/18639 0.291666666666667 1.41204545454545 0.212335804139143 0.613049169030047 GO:0050699 WW domain binding 7/3850 24/18639 0.291666666666667 1.41204545454545 0.212335804139143 0.613049169030047 GO:0070840 dynein complex binding 7/3850 24/18639 0.291666666666667 1.41204545454545 0.212335804139143 0.613049169030047 GO:0004722 protein serine/threonine phosphatase activity 25/3850 103/18639 0.242718446601942 1.17507250031522 0.212978239333993 0.613546583511834 GO:1901682 sulfur compound transmembrane transporter activity 16/3850 63/18639 0.253968253968254 1.22953617810761 0.215490350026357 0.619416094238758 GO:0140939 histone H4 methyltransferase activity 6/3850 20/18639 0.3 1.45238961038961 0.21766468186243 0.623377003301792 GO:0019213 deacetylase activity 10/3850 37/18639 0.27027027027027 1.30845910845911 0.219977816004654 0.623377003301792 GO:0005521 lamin binding 5/3850 16/18639 0.3125 1.51290584415584 0.221750371855291 0.623377003301792 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 5/3850 16/18639 0.3125 1.51290584415584 0.221750371855291 0.623377003301792 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 5/3850 16/18639 0.3125 1.51290584415584 0.221750371855291 0.623377003301792 GO:0003714 transcription corepressor activity 47/3850 204/18639 0.230392156862745 1.11539724980901 0.221924979831971 0.623377003301792 GO:0003720 telomerase activity 4/3850 12/18639 0.333333333333333 1.61376623376623 0.223078207311829 0.623377003301792 GO:0005165 neurotrophin receptor binding 4/3850 12/18639 0.333333333333333 1.61376623376623 0.223078207311829 0.623377003301792 GO:0008179 adenylate cyclase binding 4/3850 12/18639 0.333333333333333 1.61376623376623 0.223078207311829 0.623377003301792 GO:0016801 hydrolase activity, acting on ether bonds 4/3850 12/18639 0.333333333333333 1.61376623376623 0.223078207311829 0.623377003301792 GO:0016803 ether hydrolase activity 4/3850 12/18639 0.333333333333333 1.61376623376623 0.223078207311829 0.623377003301792 GO:0034452 dynactin binding 4/3850 12/18639 0.333333333333333 1.61376623376623 0.223078207311829 0.623377003301792 GO:0035251 UDP-glucosyltransferase activity 4/3850 12/18639 0.333333333333333 1.61376623376623 0.223078207311829 0.623377003301792 GO:0140311 protein sequestering activity 9/3850 33/18639 0.272727272727273 1.32035419126328 0.228254394815505 0.636478600927851 GO:0044325 transmembrane transporter binding 32/3850 136/18639 0.235294117647059 1.13912910618793 0.231388155908443 0.643841244052278 GO:0140313 molecular sequestering activity 14/3850 55/18639 0.254545454545455 1.2323305785124 0.232843322967704 0.64570697733958 GO:0019783 ubiquitin-like protein peptidase activity 30/3850 127/18639 0.236220472440945 1.14361386644851 0.23304826538463 0.64570697733958 GO:0016417 S-acyltransferase activity 8/3850 29/18639 0.275862068965517 1.33553067622033 0.236901238302725 0.651698703166299 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 8/3850 29/18639 0.275862068965517 1.33553067622033 0.236901238302725 0.651698703166299 GO:0004520 DNA endonuclease activity 11/3850 42/18639 0.261904761904762 1.26795918367347 0.237208340232944 0.651698703166299 GO:0031492 nucleosomal DNA binding 11/3850 42/18639 0.261904761904762 1.26795918367347 0.237208340232944 0.651698703166299 GO:0005048 signal sequence binding 13/3850 51/18639 0.254901960784314 1.23405653170359 0.242349866794008 0.66442558018105 GO:0004714 transmembrane receptor protein tyrosine kinase activity 15/3850 60/18639 0.25 1.21032467532468 0.245187900575099 0.670797086479044 GO:0004709 MAP kinase kinase kinase activity 7/3850 25/18639 0.28 1.35556363636364 0.245887832375885 0.671304646967635 GO:0042887 amide transmembrane transporter activity 10/3850 38/18639 0.263157894736842 1.27402597402597 0.247009391497279 0.671556783133228 GO:0043531 ADP binding 10/3850 38/18639 0.263157894736842 1.27402597402597 0.247009391497279 0.671556783133228 GO:0043495 protein-membrane adaptor activity 12/3850 47/18639 0.25531914893617 1.23607626416137 0.25250164815533 0.68506164416363 GO:0035401 histone H3Y41 kinase activity 27/3850 115/18639 0.234782608695652 1.13665273856578 0.258599533781968 0.697257007407992 GO:0101005 deubiquitinase activity 27/3850 115/18639 0.234782608695652 1.13665273856578 0.258599533781968 0.697257007407992 GO:0140801 histone H2AXY142 kinase activity 27/3850 115/18639 0.234782608695652 1.13665273856578 0.258599533781968 0.697257007407992 GO:0046906 tetrapyrrole binding 35/3850 152/18639 0.230263157894737 1.11477272727273 0.262380977803709 0.704074220617355 GO:0004712 protein serine/threonine/tyrosine kinase activity 11/3850 43/18639 0.255813953488372 1.23847176079734 0.263387253298703 0.704074220617355 GO:0005092 GDP-dissociation inhibitor activity 5/3850 17/18639 0.294117647058824 1.42391138273491 0.264365033028739 0.704074220617355 GO:0051787 misfolded protein binding 5/3850 17/18639 0.294117647058824 1.42391138273491 0.264365033028739 0.704074220617355 GO:0070403 NAD+ binding 5/3850 17/18639 0.294117647058824 1.42391138273491 0.264365033028739 0.704074220617355 GO:0070492 oligosaccharide binding 5/3850 17/18639 0.294117647058824 1.42391138273491 0.264365033028739 0.704074220617355 GO:0046332 SMAD binding 19/3850 79/18639 0.240506329113924 1.16436297879336 0.266145729939666 0.705691577712417 GO:0015215 nucleotide transmembrane transporter activity 8/3850 30/18639 0.266666666666667 1.29101298701299 0.26875763534335 0.705691577712417 GO:0016769 transferase activity, transferring nitrogenous groups 8/3850 30/18639 0.266666666666667 1.29101298701299 0.26875763534335 0.705691577712417 GO:0031210 phosphatidylcholine binding 8/3850 30/18639 0.266666666666667 1.29101298701299 0.26875763534335 0.705691577712417 GO:0043995 histone H4K5 acetyltransferase activity 8/3850 30/18639 0.266666666666667 1.29101298701299 0.26875763534335 0.705691577712417 GO:0043996 histone H4K8 acetyltransferase activity 8/3850 30/18639 0.266666666666667 1.29101298701299 0.26875763534335 0.705691577712417 GO:0043997 histone H4K12 acetyltransferase activity 8/3850 30/18639 0.266666666666667 1.29101298701299 0.26875763534335 0.705691577712417 GO:0002161 aminoacyl-tRNA editing activity 4/3850 13/18639 0.307692307692308 1.48963036963037 0.273001634730295 0.711112042560949 GO:0008253 5'-nucleotidase activity 4/3850 13/18639 0.307692307692308 1.48963036963037 0.273001634730295 0.711112042560949 GO:0019104 DNA N-glycosylase activity 4/3850 13/18639 0.307692307692308 1.48963036963037 0.273001634730295 0.711112042560949 GO:0045159 myosin II binding 4/3850 13/18639 0.307692307692308 1.48963036963037 0.273001634730295 0.711112042560949 GO:0008235 metalloexopeptidase activity 16/3850 66/18639 0.242424242424242 1.17364817001181 0.278110160256692 0.722975615806739 GO:0015216 purine nucleotide transmembrane transporter activity 7/3850 26/18639 0.269230769230769 1.30342657342657 0.280920674738801 0.72738388994868 GO:0120014 phospholipid transfer activity 7/3850 26/18639 0.269230769230769 1.30342657342657 0.280920674738801 0.72738388994868 GO:0140299 molecular sensor activity 17/3850 71/18639 0.23943661971831 1.1591841960856 0.288173279430549 0.744685405261121 GO:0001046 core promoter sequence-specific DNA binding 11/3850 44/18639 0.25 1.21032467532468 0.290457029569897 0.747626082029024 GO:0043014 alpha-tubulin binding 11/3850 44/18639 0.25 1.21032467532468 0.290457029569897 0.747626082029024 GO:0046972 histone H4K16 acetyltransferase activity 6/3850 22/18639 0.272727272727273 1.32035419126328 0.294133616444296 0.755599152479935 GO:0008234 cysteine-type peptidase activity 42/3850 187/18639 0.224598930481283 1.08735051045211 0.296575409759728 0.760375068244489 GO:0140789 histone phosphatase activity 31/3850 136/18639 0.227941176470588 1.10353132161956 0.29912892446672 0.765418130253079 GO:0042054 histone methyltransferase activity 16/3850 67/18639 0.238805970149254 1.15613103314596 0.300251556653933 0.76606724397638 GO:0008327 methyl-CpG binding 8/3850 31/18639 0.258064516129032 1.24936740678676 0.301730699926329 0.76606724397638 GO:0016878 acid-thiol ligase activity 8/3850 31/18639 0.258064516129032 1.24936740678676 0.301730699926329 0.76606724397638 GO:0070325 lipoprotein particle receptor binding 8/3850 31/18639 0.258064516129032 1.24936740678676 0.301730699926329 0.76606724397638 GO:0061980 regulatory RNA binding 14/3850 58/18639 0.241379310344828 1.16858934169279 0.302516135140428 0.766570012346132 GO:0030331 nuclear estrogen receptor binding 10/3850 40/18639 0.25 1.21032467532468 0.304114821652045 0.769127601271162 GO:0004706 JUN kinase kinase kinase activity 5/3850 18/18639 0.277777777777778 1.34480519480519 0.308585625788009 0.774431233948752 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 5/3850 18/18639 0.277777777777778 1.34480519480519 0.308585625788009 0.774431233948752 GO:1901611 phosphatidylglycerol binding 5/3850 18/18639 0.277777777777778 1.34480519480519 0.308585625788009 0.774431233948752 GO:1990381 ubiquitin-specific protease binding 5/3850 18/18639 0.277777777777778 1.34480519480519 0.308585625788009 0.774431233948752 GO:0003779 actin binding 96/3850 443/18639 0.216704288939052 1.04913019260649 0.314513002838874 0.786622822521969 GO:0016922 nuclear receptor binding 31/3850 137/18639 0.226277372262774 1.09547634846905 0.314850938342493 0.786622822521969 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 13/3850 54/18639 0.240740740740741 1.16549783549784 0.3160778341558 0.786622822521969 GO:0001671 ATPase activator activity 7/3850 27/18639 0.259259259259259 1.25515151515152 0.317060233445636 0.786622822521969 GO:0004683 calcium/calmodulin-dependent protein kinase activity 7/3850 27/18639 0.259259259259259 1.25515151515152 0.317060233445636 0.786622822521969 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 7/3850 27/18639 0.259259259259259 1.25515151515152 0.317060233445636 0.786622822521969 GO:0005313 L-glutamate transmembrane transporter activity 4/3850 14/18639 0.285714285714286 1.38322820037106 0.324501083587721 0.79600359789845 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 4/3850 14/18639 0.285714285714286 1.38322820037106 0.324501083587721 0.79600359789845 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 4/3850 14/18639 0.285714285714286 1.38322820037106 0.324501083587721 0.79600359789845 GO:0042813 Wnt receptor activity 4/3850 14/18639 0.285714285714286 1.38322820037106 0.324501083587721 0.79600359789845 GO:0046030 inositol trisphosphate phosphatase activity 4/3850 14/18639 0.285714285714286 1.38322820037106 0.324501083587721 0.79600359789845 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/3850 14/18639 0.285714285714286 1.38322820037106 0.324501083587721 0.79600359789845 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 19/3850 82/18639 0.231707317073171 1.12176433322775 0.326898071060877 0.80037895447363 GO:0005006 epidermal growth factor receptor activity 12/3850 50/18639 0.24 1.16191168831169 0.330720884674357 0.806711690654274 GO:0005007 fibroblast growth factor receptor activity 12/3850 50/18639 0.24 1.16191168831169 0.330720884674357 0.806711690654274 GO:0017080 sodium channel regulator activity 10/3850 41/18639 0.24390243902439 1.18080456129237 0.333805412908325 0.809137265389647 GO:0000295 adenine nucleotide transmembrane transporter activity 6/3850 23/18639 0.260869565217391 1.26294748729531 0.334195391605379 0.809137265389647 GO:0043274 phospholipase binding 6/3850 23/18639 0.260869565217391 1.26294748729531 0.334195391605379 0.809137265389647 GO:0070577 lysine-acetylated histone binding 6/3850 23/18639 0.260869565217391 1.26294748729531 0.334195391605379 0.809137265389647 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/3850 32/18639 0.25 1.21032467532468 0.335527293731414 0.810143587979684 GO:0008190 eukaryotic initiation factor 4E binding 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0016868 intramolecular phosphotransferase activity 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0030957 Tat protein binding 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0031434 mitogen-activated protein kinase kinase binding 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0031996 thioesterase binding 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/3850 10/18639 0.3 1.45238961038961 0.342060626035867 0.810143587979684 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 5/3850 19/18639 0.263157894736842 1.27402597402597 0.353700828343485 0.830076909868539 GO:0046624 sphingolipid transporter activity 5/3850 19/18639 0.263157894736842 1.27402597402597 0.353700828343485 0.830076909868539 GO:0050145 nucleoside monophosphate kinase activity 5/3850 19/18639 0.263157894736842 1.27402597402597 0.353700828343485 0.830076909868539 GO:0046966 nuclear thyroid hormone receptor binding 7/3850 28/18639 0.25 1.21032467532468 0.353931271200628 0.830076909868539 GO:0051019 mitogen-activated protein kinase binding 7/3850 28/18639 0.25 1.21032467532468 0.353931271200628 0.830076909868539 GO:0048029 monosaccharide binding 17/3850 74/18639 0.22972972972973 1.11219024219024 0.354293363062664 0.830076909868539 GO:0005021 vascular endothelial growth factor receptor activity 12/3850 51/18639 0.235294117647059 1.13912910618793 0.35791196709908 0.836888938430188 GO:0015297 antiporter activity 30/3850 135/18639 0.222222222222222 1.07584415584416 0.358483460982739 0.836888938430188 GO:0004713 protein tyrosine kinase activity 31/3850 140/18639 0.221428571428571 1.07200185528757 0.36341788823211 0.846719353914072 GO:0048487 beta-tubulin binding 10/3850 42/18639 0.238095238095238 1.15269016697588 0.363991998119383 0.846719353914072 GO:0005200 structural constituent of cytoskeleton 25/3850 112/18639 0.223214285714286 1.08064703153989 0.366988596594004 0.849887759068185 GO:0019212 phosphatase inhibitor activity 13/3850 56/18639 0.232142857142857 1.12387291280148 0.367989965036256 0.849887759068185 GO:0016782 transferase activity, transferring sulphur-containing groups 16/3850 70/18639 0.228571428571429 1.10658256029685 0.369311578912652 0.849887759068185 GO:0071889 14-3-3 protein binding 8/3850 33/18639 0.242424242424242 1.17364817001181 0.369854621384505 0.849887759068185 GO:0140033 acetylation-dependent protein binding 6/3850 24/18639 0.25 1.21032467532468 0.374815254094125 0.849887759068185 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 20/3850 89/18639 0.224719101123595 1.08793229242667 0.375973411699041 0.849887759068185 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 20/3850 89/18639 0.224719101123595 1.08793229242667 0.375973411699041 0.849887759068185 GO:0004467 long-chain fatty acid-CoA ligase activity 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0042809 nuclear vitamin D receptor binding 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0050780 dopamine receptor binding 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0061578 K63-linked deubiquitinase activity 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0120283 protein serine/threonine kinase binding 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0141050 histone H3K deacetylase activity 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0141051 histone H4K deacetylase activity 4/3850 15/18639 0.266666666666667 1.29101298701299 0.376511065114479 0.849887759068185 GO:0019003 GDP binding 17/3850 75/18639 0.226666666666667 1.09736103896104 0.376998455232283 0.849887759068185 GO:0016836 hydro-lyase activity 14/3850 61/18639 0.229508196721311 1.11111773472429 0.377076637931402 0.849887759068185 GO:0008237 metallopeptidase activity 40/3850 184/18639 0.217391304347826 1.05245623941276 0.386110605035708 0.858136670182383 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 7/3850 29/18639 0.241379310344828 1.16858934169279 0.391168099849961 0.858136670182383 GO:0010484 histone H3 acetyltransferase activity 7/3850 29/18639 0.241379310344828 1.16858934169279 0.391168099849961 0.858136670182383 GO:0043236 laminin binding 7/3850 29/18639 0.241379310344828 1.16858934169279 0.391168099849961 0.858136670182383 GO:0051861 glycolipid binding 7/3850 29/18639 0.241379310344828 1.16858934169279 0.391168099849961 0.858136670182383 GO:0097472 cyclin-dependent protein kinase activity 7/3850 29/18639 0.241379310344828 1.16858934169279 0.391168099849961 0.858136670182383 GO:0106222 lncRNA binding 7/3850 29/18639 0.241379310344828 1.16858934169279 0.391168099849961 0.858136670182383 GO:0140793 histone H2AXY142 phosphatase activity 20/3850 90/18639 0.222222222222222 1.07584415584416 0.39696562365612 0.858136670182383 GO:0005178 integrin binding 35/3850 161/18639 0.217391304347826 1.05245623941276 0.397089493268766 0.858136670182383 GO:0015095 magnesium ion transmembrane transporter activity 5/3850 20/18639 0.25 1.21032467532468 0.399046210503837 0.858136670182383 GO:0016408 C-acyltransferase activity 5/3850 20/18639 0.25 1.21032467532468 0.399046210503837 0.858136670182383 GO:0030742 GTP-dependent protein binding 5/3850 20/18639 0.25 1.21032467532468 0.399046210503837 0.858136670182383 GO:0000099 sulfur amino acid transmembrane transporter activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0004016 adenylate cyclase activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0004143 ATP-dependent diacylglycerol kinase activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0008271 secondary active sulfate transmembrane transporter activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0010854 adenylate cyclase regulator activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0019107 myristoyltransferase activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0034056 estrogen response element binding 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0035252 UDP-xylosyltransferase activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0042285 xylosyltransferase activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0045294 alpha-catenin binding 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0050998 nitric-oxide synthase binding 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0097493 structural molecule activity conferring elasticity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0140537 transcription regulator activator activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0180030 inositol phosphate kinase activity 3/3850 11/18639 0.272727272727273 1.32035419126328 0.404373440452673 0.858136670182383 GO:0052866 phosphatidylinositol phosphate phosphatase activity 8/3850 34/18639 0.235294117647059 1.13912910618793 0.40442718681112 0.858136670182383 GO:0090482 vitamin transmembrane transporter activity 8/3850 34/18639 0.235294117647059 1.13912910618793 0.40442718681112 0.858136670182383 GO:0033192 calmodulin-dependent protein phosphatase activity 18/3850 81/18639 0.222222222222222 1.07584415584416 0.406381963350738 0.858136670182383 GO:0140791 histone H2AXS140 phosphatase activity 18/3850 81/18639 0.222222222222222 1.07584415584416 0.406381963350738 0.858136670182383 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 18/3850 81/18639 0.222222222222222 1.07584415584416 0.406381963350738 0.858136670182383 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 18/3850 81/18639 0.222222222222222 1.07584415584416 0.406381963350738 0.858136670182383 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 18/3850 81/18639 0.222222222222222 1.07584415584416 0.406381963350738 0.858136670182383 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 18/3850 81/18639 0.222222222222222 1.07584415584416 0.406381963350738 0.858136670182383 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 18/3850 81/18639 0.222222222222222 1.07584415584416 0.406381963350738 0.858136670182383 GO:1990439 MAP kinase serine/threonine phosphatase activity 18/3850 81/18639 0.222222222222222 1.07584415584416 0.406381963350738 0.858136670182383 GO:0005003 ephrin receptor activity 12/3850 53/18639 0.226415094339623 1.09614310218084 0.413108859552901 0.869527518897638 GO:0005005 transmembrane-ephrin receptor activity 12/3850 53/18639 0.226415094339623 1.09614310218084 0.413108859552901 0.869527518897638 GO:0051020 GTPase binding 67/3850 315/18639 0.212698412698413 1.02973654916512 0.415243717869715 0.872613610016068 GO:0019209 kinase activator activity 32/3850 148/18639 0.216216216216216 1.04676728676729 0.417473072801768 0.875888038595349 GO:0030295 protein kinase activator activity 30/3850 139/18639 0.215827338129496 1.04488461179109 0.426415101661015 0.879643433087352 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 4/3850 16/18639 0.25 1.21032467532468 0.428097962867541 0.879643433087352 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/3850 16/18639 0.25 1.21032467532468 0.428097962867541 0.879643433087352 GO:0008142 oxysterol binding 4/3850 16/18639 0.25 1.21032467532468 0.428097962867541 0.879643433087352 GO:0015562 efflux transmembrane transporter activity 4/3850 16/18639 0.25 1.21032467532468 0.428097962867541 0.879643433087352 GO:0016722 oxidoreductase activity, acting on metal ions 4/3850 16/18639 0.25 1.21032467532468 0.428097962867541 0.879643433087352 GO:0031435 mitogen-activated protein kinase kinase kinase binding 4/3850 16/18639 0.25 1.21032467532468 0.428097962867541 0.879643433087352 GO:0140327 flippase activity 4/3850 16/18639 0.25 1.21032467532468 0.428097962867541 0.879643433087352 GO:0140328 floppase activity 4/3850 16/18639 0.25 1.21032467532468 0.428097962867541 0.879643433087352 GO:0001968 fibronectin binding 7/3850 30/18639 0.233333333333333 1.12963636363636 0.428423458612843 0.879643433087352 GO:0033549 MAP kinase phosphatase activity 18/3850 82/18639 0.219512195121951 1.06272410516313 0.428736808057261 0.879643433087352 GO:0005004 GPI-linked ephrin receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0005008 hepatocyte growth factor receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0005009 insulin receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0005011 macrophage colony-stimulating factor receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0005018 platelet-derived growth factor alpha-receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0005020 stem cell factor receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0008288 boss receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0036332 placental growth factor receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0038062 protein tyrosine kinase collagen receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0060175 brain-derived neurotrophic factor receptor activity 11/3850 49/18639 0.224489795918367 1.0868221574344 0.433418181973309 0.879643433087352 GO:0140566 histone reader activity 8/3850 35/18639 0.228571428571429 1.10658256029685 0.438972704514179 0.889533197812117 GO:0061134 peptidase regulator activity 48/3850 226/18639 0.212389380530973 1.02824043213424 0.440091443426907 0.890417571584673 GO:0015485 cholesterol binding 12/3850 54/18639 0.222222222222222 1.07584415584416 0.440832009666358 0.890535251725383 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/3850 21/18639 0.238095238095238 1.15269016697588 0.444022624116077 0.895594319121298 GO:0071949 FAD binding 9/3850 40/18639 0.225 1.08929220779221 0.447883451377521 0.901987506246397 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 18/3850 83/18639 0.216867469879518 1.04992020028165 0.451114726604184 0.907095097409029 GO:0030247 polysaccharide binding 6/3850 26/18639 0.230769230769231 1.11722277722278 0.455911727342947 0.913924430387936 GO:0097602 cullin family protein binding 6/3850 26/18639 0.230769230769231 1.11722277722278 0.455911727342947 0.913924430387936 GO:0016279 protein-lysine N-methyltransferase activity 15/3850 69/18639 0.217391304347826 1.05245623941276 0.459110473788162 0.918925104744711 GO:0005017 platelet-derived growth factor receptor activity 11/3850 50/18639 0.22 1.06508571428571 0.462384086339679 0.919046615465161 GO:0005019 platelet-derived growth factor beta-receptor activity 11/3850 50/18639 0.22 1.06508571428571 0.462384086339679 0.919046615465161 GO:0004725 protein tyrosine phosphatase activity 21/3850 98/18639 0.214285714285714 1.03742115027829 0.464695350728515 0.919046615465161 GO:0015132 prostaglandin transmembrane transporter activity 3/3850 12/18639 0.25 1.21032467532468 0.464805184832955 0.919046615465161 GO:0017166 vinculin binding 3/3850 12/18639 0.25 1.21032467532468 0.464805184832955 0.919046615465161 GO:0035259 nuclear glucocorticoid receptor binding 3/3850 12/18639 0.25 1.21032467532468 0.464805184832955 0.919046615465161 GO:0070008 serine-type exopeptidase activity 3/3850 12/18639 0.25 1.21032467532468 0.464805184832955 0.919046615465161 GO:0097677 STAT family protein binding 3/3850 12/18639 0.25 1.21032467532468 0.464805184832955 0.919046615465161 GO:0098632 cell-cell adhesion mediator activity 12/3850 55/18639 0.218181818181818 1.05628335301063 0.468457436417177 0.924866799583081 GO:0004869 cysteine-type endopeptidase inhibitor activity 8/3850 36/18639 0.222222222222222 1.07584415584416 0.473236903902251 0.92584368083734 GO:0016409 palmitoyltransferase activity 8/3850 36/18639 0.222222222222222 1.07584415584416 0.473236903902251 0.92584368083734 GO:0044390 ubiquitin-like protein conjugating enzyme binding 8/3850 36/18639 0.222222222222222 1.07584415584416 0.473236903902251 0.92584368083734 GO:0017018 myosin phosphatase activity 18/3850 84/18639 0.214285714285714 1.03742115027829 0.473445064282143 0.92584368083734 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 4/3850 17/18639 0.235294117647059 1.13912910618793 0.478477325894865 0.92584368083734 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/3850 17/18639 0.235294117647059 1.13912910618793 0.478477325894865 0.92584368083734 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/3850 17/18639 0.235294117647059 1.13912910618793 0.478477325894865 0.92584368083734 GO:0019198 transmembrane receptor protein phosphatase activity 4/3850 17/18639 0.235294117647059 1.13912910618793 0.478477325894865 0.92584368083734 GO:0001727 lipid kinase activity 9/3850 41/18639 0.219512195121951 1.06272410516313 0.479967899696983 0.92584368083734 GO:0004812 aminoacyl-tRNA ligase activity 9/3850 41/18639 0.219512195121951 1.06272410516313 0.479967899696983 0.92584368083734 GO:0015175 neutral L-amino acid transmembrane transporter activity 9/3850 41/18639 0.219512195121951 1.06272410516313 0.479967899696983 0.92584368083734 GO:0016875 ligase activity, forming carbon-oxygen bonds 9/3850 41/18639 0.219512195121951 1.06272410516313 0.479967899696983 0.92584368083734 GO:0016278 lysine N-methyltransferase activity 15/3850 70/18639 0.214285714285714 1.03742115027829 0.483601081481483 0.92584368083734 GO:0008093 cytoskeletal anchor activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0031683 G-protein beta/gamma-subunit complex binding 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0032931 histone H3K56 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0043992 histone H3K9 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0043993 histone H3K18 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0043994 histone H3K23 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0043999 histone H2AK5 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0044012 histone H2AK9 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0044014 histone H2BK5 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0044015 histone H2BK12 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0044016 histone H3K4 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0044017 histone H3K27 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0044018 histone H3K36 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0140908 histone H3K122 acetyltransferase activity 5/3850 22/18639 0.227272727272727 1.10029515938607 0.488107626372483 0.92584368083734 GO:0005010 insulin-like growth factor receptor activity 11/3850 51/18639 0.215686274509804 1.04420168067227 0.491113919130844 0.92871501167281 GO:0005030 neurotrophin receptor activity 11/3850 51/18639 0.215686274509804 1.04420168067227 0.491113919130844 0.92871501167281 GO:0031267 small GTPase binding 59/3850 283/18639 0.208480565371025 1.00931669037676 0.491756377828285 0.92871501167281 GO:0023026 MHC class II protein complex binding 6/3850 27/18639 0.222222222222222 1.07584415584416 0.495583582742179 0.93241245090711 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 6/3850 27/18639 0.222222222222222 1.07584415584416 0.495583582742179 0.93241245090711 GO:0030170 pyridoxal phosphate binding 12/3850 56/18639 0.214285714285714 1.03742115027829 0.495857655884701 0.93241245090711 GO:0019905 syntaxin binding 13/3850 61/18639 0.213114754098361 1.03175218224399 0.500190202859648 0.939206064362361 GO:0098631 cell adhesion mediator activity 16/3850 76/18639 0.210526315789474 1.01922077922078 0.511358195935206 0.958796617378511 GO:1901681 sulfur compound binding 57/3850 275/18639 0.207272727272727 1.00346918536009 0.512439119534162 0.959444836430533 GO:0001784 phosphotyrosine residue binding 10/3850 47/18639 0.212765957446809 1.03006355346781 0.515723213538817 0.961129447142477 GO:0019787 ubiquitin-like protein transferase activity 99/3850 479/18639 0.206680584551148 1.00060244557113 0.515850952862471 0.961129447142477 GO:0005172 vascular endothelial growth factor receptor binding 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0008035 high-density lipoprotein particle binding 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0019855 calcium channel inhibitor activity 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0030955 potassium ion binding 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0031432 titin binding 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0035673 oligopeptide transmembrane transporter activity 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0071714 icosanoid transmembrane transporter activity 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0140333 glycerophospholipid flippase activity 3/3850 13/18639 0.230769230769231 1.11722277722278 0.522346249863752 0.961129447142477 GO:0070279 vitamin B6 binding 12/3850 57/18639 0.210526315789474 1.01922077922078 0.522913339058359 0.961129447142477 GO:0000900 mRNA regulatory element binding translation repressor activity 4/3850 18/18639 0.222222222222222 1.07584415584416 0.527017811639681 0.961899642223473 GO:0008308 voltage-gated monoatomic anion channel activity 4/3850 18/18639 0.222222222222222 1.07584415584416 0.527017811639681 0.961899642223473 GO:0015172 acidic amino acid transmembrane transporter activity 4/3850 18/18639 0.222222222222222 1.07584415584416 0.527017811639681 0.961899642223473 GO:0031690 adrenergic receptor binding 4/3850 18/18639 0.222222222222222 1.07584415584416 0.527017811639681 0.961899642223473 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/3850 18/18639 0.222222222222222 1.07584415584416 0.527017811639681 0.961899642223473 GO:0044013 histone H2B acetyltransferase activity 5/3850 23/18639 0.217391304347826 1.05245623941276 0.5308610249189 0.966211488869128 GO:0099186 structural constituent of postsynapse 5/3850 23/18639 0.217391304347826 1.05245623941276 0.5308610249189 0.966211488869128 GO:0036408 histone H3K14 acetyltransferase activity 6/3850 28/18639 0.214285714285714 1.03742115027829 0.53421603134442 0.970963678139928 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 7/3850 33/18639 0.212121212121212 1.02694214876033 0.537238735963637 0.975099513814389 GO:0016755 aminoacyltransferase activity 102/3850 496/18639 0.205645161290323 0.995589652283201 0.538505566440115 0.976041339172708 GO:0008081 phosphoric diester hydrolase activity 18/3850 87/18639 0.206896551724138 1.00164800716525 0.539482014002673 0.976066681158099 GO:0005109 frizzled binding 8/3850 38/18639 0.210526315789474 1.01922077922078 0.540015435859117 0.976066681158099 GO:0008238 exopeptidase activity 21/3850 102/18639 0.205882352941176 0.996737967914438 0.546118235236003 0.985732084347142 GO:0038064 collagen receptor activity 11/3850 53/18639 0.207547169811321 1.00479784366577 0.547326746504899 0.986548900813388 GO:0005507 copper ion binding 13/3850 63/18639 0.206349206349206 0.99899814471243 0.551606084588107 0.992890952258593 GO:0019199 transmembrane receptor protein kinase activity 16/3850 78/18639 0.205128205128205 0.993086913086913 0.557412704870204 1 GO:0061659 ubiquitin-like protein ligase activity 76/3850 372/18639 0.204301075268817 0.989082530372853 0.564087134411541 1 GO:0042626 ATPase-coupled transmembrane transporter activity 20/3850 98/18639 0.204081632653061 0.988020143122184 0.564325222918382 1 GO:0004843 cysteine-type deubiquitinase activity 22/3850 108/18639 0.203703703703704 0.986190476190476 0.567510536156921 1 GO:0015295 solute:proton symporter activity 5/3850 24/18639 0.208333333333333 1.0086038961039 0.571925701451736 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 5/3850 24/18639 0.208333333333333 1.0086038961039 0.571925701451736 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 5/3850 24/18639 0.208333333333333 1.0086038961039 0.571925701451736 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 5/3850 24/18639 0.208333333333333 1.0086038961039 0.571925701451736 1 GO:0050431 transforming growth factor beta binding 5/3850 24/18639 0.208333333333333 1.0086038961039 0.571925701451736 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 5/3850 24/18639 0.208333333333333 1.0086038961039 0.571925701451736 1 GO:0016248 channel inhibitor activity 9/3850 44/18639 0.204545454545455 0.990265643447462 0.572821145239084 1 GO:0008381 mechanosensitive monoatomic ion channel activity 4/3850 19/18639 0.210526315789474 1.01922077922078 0.573235673852 1 GO:0015245 fatty acid transmembrane transporter activity 4/3850 19/18639 0.210526315789474 1.01922077922078 0.573235673852 1 GO:0031420 alkali metal ion binding 4/3850 19/18639 0.210526315789474 1.01922077922078 0.573235673852 1 GO:0042800 histone H3K4 methyltransferase activity 4/3850 19/18639 0.210526315789474 1.01922077922078 0.573235673852 1 GO:0031490 chromatin DNA binding 26/3850 128/18639 0.203125 0.983388798701299 0.573458811700915 1 GO:0016763 pentosyltransferase activity 10/3850 49/18639 0.204081632653061 0.988020143122184 0.573646349205297 1 GO:0031593 polyubiquitin modification-dependent protein binding 12/3850 59/18639 0.203389830508475 0.984670922298041 0.57556062200132 1 GO:0008191 metalloendopeptidase inhibitor activity 3/3850 14/18639 0.214285714285714 1.03742115027829 0.576304022484488 1 GO:0008494 translation activator activity 3/3850 14/18639 0.214285714285714 1.03742115027829 0.576304022484488 1 GO:0008559 ABC-type xenobiotic transporter activity 3/3850 14/18639 0.214285714285714 1.03742115027829 0.576304022484488 1 GO:0015926 glucosidase activity 3/3850 14/18639 0.214285714285714 1.03742115027829 0.576304022484488 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 3/3850 14/18639 0.214285714285714 1.03742115027829 0.576304022484488 1 GO:0070742 C2H2 zinc finger domain binding 3/3850 14/18639 0.214285714285714 1.03742115027829 0.576304022484488 1 GO:0071933 Arp2/3 complex binding 3/3850 14/18639 0.214285714285714 1.03742115027829 0.576304022484488 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 12/3850 60/18639 0.2 0.96825974025974 0.600962556065702 1 GO:0038024 cargo receptor activity 13/3850 65/18639 0.2 0.96825974025974 0.601004695360679 1 GO:0120013 lipid transfer activity 13/3850 65/18639 0.2 0.96825974025974 0.601004695360679 1 GO:0046915 transition metal ion transmembrane transporter activity 9/3850 45/18639 0.2 0.96825974025974 0.60212847935152 1 GO:0141110 transporter inhibitor activity 9/3850 45/18639 0.2 0.96825974025974 0.60212847935152 1 GO:0061135 endopeptidase regulator activity 37/3850 184/18639 0.201086956521739 0.973522021456804 0.602258658983559 1 GO:0001965 G-protein alpha-subunit binding 6/3850 30/18639 0.2 0.96825974025974 0.607310239145073 1 GO:0070566 adenylyltransferase activity 6/3850 30/18639 0.2 0.96825974025974 0.607310239145073 1 GO:0003707 nuclear steroid receptor activity 5/3850 25/18639 0.2 0.96825974025974 0.611024832629173 1 GO:0008139 nuclear localization sequence binding 5/3850 25/18639 0.2 0.96825974025974 0.611024832629173 1 GO:0008483 transaminase activity 5/3850 25/18639 0.2 0.96825974025974 0.611024832629173 1 GO:0019706 protein-cysteine S-palmitoyltransferase activity 5/3850 25/18639 0.2 0.96825974025974 0.611024832629173 1 GO:0019707 protein-cysteine S-acyltransferase activity 5/3850 25/18639 0.2 0.96825974025974 0.611024832629173 1 GO:0016505 peptidase activator activity involved in apoptotic process 4/3850 20/18639 0.2 0.96825974025974 0.616783039689041 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/3850 20/18639 0.2 0.96825974025974 0.616783039689041 1 GO:0042288 MHC class I protein binding 4/3850 20/18639 0.2 0.96825974025974 0.616783039689041 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 17/3850 86/18639 0.197674418604651 0.957000906070674 0.623160905954526 1 GO:0001618 virus receptor activity 16/3850 81/18639 0.197530864197531 0.956305916305916 0.623334366830501 1 GO:0030971 receptor tyrosine kinase binding 16/3850 81/18639 0.197530864197531 0.956305916305916 0.623334366830501 1 GO:0008013 beta-catenin binding 21/3850 106/18639 0.19811320754717 0.959125214408233 0.623409531512379 1 GO:0017022 myosin binding 15/3850 76/18639 0.197368421052632 0.955519480519481 0.623638663497487 1 GO:0005523 tropomyosin binding 3/3850 15/18639 0.2 0.96825974025974 0.626252261826991 1 GO:0015116 sulfate transmembrane transporter activity 3/3850 15/18639 0.2 0.96825974025974 0.626252261826991 1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/3850 15/18639 0.2 0.96825974025974 0.626252261826991 1 GO:0031005 filamin binding 3/3850 15/18639 0.2 0.96825974025974 0.626252261826991 1 GO:0048531 beta-1,3-galactosyltransferase activity 3/3850 15/18639 0.2 0.96825974025974 0.626252261826991 1 GO:0051371 muscle alpha-actinin binding 3/3850 15/18639 0.2 0.96825974025974 0.626252261826991 1 GO:0030276 clathrin binding 9/3850 46/18639 0.195652173913043 0.947210615471485 0.630409470178604 1 GO:0042169 SH2 domain binding 8/3850 41/18639 0.195121951219512 0.944643649033893 0.633078482552045 1 GO:0061650 ubiquitin-like protein conjugating enzyme activity 8/3850 41/18639 0.195121951219512 0.944643649033893 0.633078482552045 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 6/3850 31/18639 0.193548387096774 0.937025555090071 0.641374573364752 1 GO:0016411 acylglycerol O-acyltransferase activity 6/3850 31/18639 0.193548387096774 0.937025555090071 0.641374573364752 1 GO:0017147 Wnt-protein binding 6/3850 31/18639 0.193548387096774 0.937025555090071 0.641374573364752 1 GO:0047499 calcium-independent phospholipase A2 activity 6/3850 31/18639 0.193548387096774 0.937025555090071 0.641374573364752 1 GO:0140457 protein demethylase activity 6/3850 31/18639 0.193548387096774 0.937025555090071 0.641374573364752 1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0005381 iron ion transmembrane transporter activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0005528 FK506 binding 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0015643 toxic substance binding 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0019531 oxalate transmembrane transporter activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0035374 chondroitin sulfate binding 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0042975 peroxisome proliferator activated receptor binding 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0043422 protein kinase B binding 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0045322 unmethylated CpG binding 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0050308 sugar-phosphatase activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0070097 delta-catenin binding 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0070739 protein-glutamic acid ligase activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0070740 tubulin-glutamic acid ligase activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0140999 histone H3K4 trimethyltransferase activity 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/3850 10/18639 0.2 0.96825974025974 0.643730433668581 1 GO:0140272 exogenous protein binding 16/3850 82/18639 0.195121951219512 0.944643649033893 0.64424530190328 1 GO:0004842 ubiquitin-protein transferase activity 90/3850 449/18639 0.200445434298441 0.970416220750296 0.645530953232885 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/3850 26/18639 0.192307692307692 0.931018981018981 0.647956524363988 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 5/3850 26/18639 0.192307692307692 0.931018981018981 0.647956524363988 1 GO:0008198 ferrous iron binding 5/3850 26/18639 0.192307692307692 0.931018981018981 0.647956524363988 1 GO:0030507 spectrin binding 5/3850 26/18639 0.192307692307692 0.931018981018981 0.647956524363988 1 GO:0034237 protein kinase A regulatory subunit binding 5/3850 26/18639 0.192307692307692 0.931018981018981 0.647956524363988 1 GO:0043548 phosphatidylinositol 3-kinase binding 5/3850 26/18639 0.192307692307692 0.931018981018981 0.647956524363988 1 GO:0050681 nuclear androgen receptor binding 5/3850 26/18639 0.192307692307692 0.931018981018981 0.647956524363988 1 GO:0052742 phosphatidylinositol kinase activity 5/3850 26/18639 0.192307692307692 0.931018981018981 0.647956524363988 1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/3850 21/18639 0.19047619047619 0.922152133580705 0.65743254923562 1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/3850 21/18639 0.19047619047619 0.922152133580705 0.65743254923562 1 GO:0009975 cyclase activity 4/3850 21/18639 0.19047619047619 0.922152133580705 0.65743254923562 1 GO:0042056 chemoattractant activity 8/3850 42/18639 0.19047619047619 0.922152133580705 0.661662198202802 1 GO:0030165 PDZ domain binding 16/3850 83/18639 0.192771084337349 0.933262400250352 0.664550210909153 1 GO:0043394 proteoglycan binding 7/3850 37/18639 0.189189189189189 0.915921375921376 0.666859929973362 1 GO:0005548 phospholipid transporter activity 13/3850 68/18639 0.191176470588235 0.925542398777693 0.670041090852504 1 GO:0032934 sterol binding 13/3850 68/18639 0.191176470588235 0.925542398777693 0.670041090852504 1 GO:0000062 fatty-acyl-CoA binding 3/3850 16/18639 0.1875 0.907743506493507 0.671980176971479 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 3/3850 16/18639 0.1875 0.907743506493507 0.671980176971479 1 GO:0004708 MAP kinase kinase activity 3/3850 16/18639 0.1875 0.907743506493507 0.671980176971479 1 GO:0005149 interleukin-1 receptor binding 3/3850 16/18639 0.1875 0.907743506493507 0.671980176971479 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/3850 16/18639 0.1875 0.907743506493507 0.671980176971479 1 GO:0022858 alanine transmembrane transporter activity 3/3850 16/18639 0.1875 0.907743506493507 0.671980176971479 1 GO:0030275 LRR domain binding 3/3850 16/18639 0.1875 0.907743506493507 0.671980176971479 1 GO:0042910 xenobiotic transmembrane transporter activity 6/3850 32/18639 0.1875 0.907743506493507 0.673599548443708 1 GO:0047498 calcium-dependent phospholipase A2 activity 6/3850 32/18639 0.1875 0.907743506493507 0.673599548443708 1 GO:0035091 phosphatidylinositol binding 56/3850 284/18639 0.197183098591549 0.954622279129321 0.675767871862757 1 GO:0004864 protein phosphatase inhibitor activity 10/3850 53/18639 0.188679245283019 0.913452585150698 0.679184928237531 1 GO:0016405 CoA-ligase activity 5/3850 27/18639 0.185185185185185 0.896536796536797 0.682586738368944 1 GO:0035255 ionotropic glutamate receptor binding 5/3850 27/18639 0.185185185185185 0.896536796536797 0.682586738368944 1 GO:1901981 phosphatidylinositol phosphate binding 36/3850 185/18639 0.194594594594595 0.942090558090558 0.684966954407442 1 GO:0008200 ion channel inhibitor activity 8/3850 43/18639 0.186046511627907 0.90070673512534 0.6888764407856 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 25/3850 130/18639 0.192307692307692 0.931018981018981 0.689863096058402 1 GO:0050321 tau-protein kinase activity 4/3850 22/18639 0.181818181818182 0.880236127508855 0.695060309871873 1 GO:0000146 microfilament motor activity 7/3850 38/18639 0.184210526315789 0.891818181818182 0.695502235095934 1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0002162 dystroglycan binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0005225 volume-sensitive anion channel activity 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0008046 axon guidance receptor activity 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0008172 S-methyltransferase activity 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0008199 ferric iron binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0008432 JUN kinase binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0015173 aromatic amino acid transmembrane transporter activity 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0019203 carbohydrate phosphatase activity 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0019206 nucleoside kinase activity 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0019215 intermediate filament binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0019864 IgG binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0031731 CCR6 chemokine receptor binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0032794 GTPase activating protein binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0043522 leucine zipper domain binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0048185 activin binding 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/3850 11/18639 0.181818181818182 0.880236127508855 0.69692087660545 1 GO:0004879 nuclear receptor activity 11/3850 59/18639 0.186440677966102 0.902615012106537 0.698500954097234 1 GO:0140416 transcription regulator inhibitor activity 6/3850 33/18639 0.181818181818182 0.880236127508855 0.703901951217058 1 GO:0035254 glutamate receptor binding 9/3850 49/18639 0.183673469387755 0.889218128809966 0.708270500902239 1 GO:0005516 calmodulin binding 40/3850 207/18639 0.193236714975845 0.935516657255788 0.70911234578837 1 GO:0004550 nucleoside diphosphate kinase activity 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:0017110 nucleoside diphosphate phosphatase activity 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:0030169 low-density lipoprotein particle binding 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:0030548 acetylcholine receptor regulator activity 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:1901567 fatty acid derivative binding 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:1990226 histone methyltransferase binding 3/3850 17/18639 0.176470588235294 0.854346829640947 0.713445073630754 1 GO:0001223 transcription coactivator binding 8/3850 44/18639 0.181818181818182 0.880236127508855 0.714666506462604 1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/3850 28/18639 0.178571428571429 0.864517625231911 0.714841239896014 1 GO:0061630 ubiquitin protein ligase activity 69/3850 353/18639 0.195467422096317 0.946316176741106 0.718233505360185 1 GO:0098531 ligand-modulated transcription factor activity 11/3850 60/18639 0.183333333333333 0.887571428571428 0.720397329165538 1 GO:0015101 organic cation transmembrane transporter activity 15/3850 81/18639 0.185185185185185 0.896536796536797 0.724524753552957 1 GO:0008374 O-acyltransferase activity 10/3850 55/18639 0.181818181818182 0.880236127508855 0.725597479845435 1 GO:0005212 structural constituent of eye lens 4/3850 23/18639 0.173913043478261 0.841964991530209 0.729628580388288 1 GO:0031681 G-protein beta-subunit binding 4/3850 23/18639 0.173913043478261 0.841964991530209 0.729628580388288 1 GO:0042171 lysophosphatidic acid acyltransferase activity 4/3850 23/18639 0.173913043478261 0.841964991530209 0.729628580388288 1 GO:0071617 lysophospholipid acyltransferase activity 4/3850 23/18639 0.173913043478261 0.841964991530209 0.729628580388288 1 GO:0043178 alcohol binding 17/3850 92/18639 0.184782608695652 0.894587803500847 0.736019466177466 1 GO:0140303 intramembrane lipid transporter activity 8/3850 45/18639 0.177777777777778 0.860675324675325 0.738999052864999 1 GO:0005085 guanyl-nucleotide exchange factor activity 44/3850 230/18639 0.191304347826087 0.92616149068323 0.741441119393352 1 GO:0004032 aldose reductase (NADPH) activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0004300 enoyl-CoA hydratase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0004875 complement receptor activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0005527 macrolide binding 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0008603 cAMP-dependent protein kinase regulator activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0010853 cyclase activator activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0016840 carbon-nitrogen lyase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0035497 cAMP response element binding 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0042301 phosphate ion binding 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0045295 gamma-catenin binding 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0070410 co-SMAD binding 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:1990817 poly(A) RNA polymerase activity 2/3850 12/18639 0.166666666666667 0.806883116883117 0.743344014959949 1 GO:0004629 phospholipase C activity 5/3850 29/18639 0.172413793103448 0.834706672637707 0.744697147574637 1 GO:0032451 demethylase activity 7/3850 40/18639 0.175 0.847227272727273 0.747790680751333 1 GO:0034185 apolipoprotein binding 3/3850 18/18639 0.166666666666667 0.806883116883117 0.750730526028969 1 GO:0099602 neurotransmitter receptor regulator activity 3/3850 18/18639 0.166666666666667 0.806883116883117 0.750730526028969 1 GO:0051213 dioxygenase activity 17/3850 93/18639 0.182795698924731 0.884968579807289 0.752548373235607 1 GO:0016500 protein-hormone receptor activity 12/3850 67/18639 0.17910447761194 0.867098274859469 0.755489786408382 1 GO:0019842 vitamin binding 28/3850 150/18639 0.186666666666667 0.903709090909091 0.756590728731749 1 GO:0004623 phospholipase A2 activity 6/3850 35/18639 0.171428571428571 0.829936920222634 0.758593847800908 1 GO:0005154 epidermal growth factor receptor binding 6/3850 35/18639 0.171428571428571 0.829936920222634 0.758593847800908 1 GO:0004620 phospholipase activity 20/3850 109/18639 0.18348623853211 0.888311688311688 0.759225168772453 1 GO:0033218 amide binding 47/3850 247/18639 0.190283400809717 0.921218781218781 0.760399636890394 1 GO:0015179 L-amino acid transmembrane transporter activity 11/3850 62/18639 0.17741935483871 0.858940092165899 0.761025025891621 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/3850 24/18639 0.166666666666667 0.806883116883117 0.761169156175599 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/3850 24/18639 0.166666666666667 0.806883116883117 0.761169156175599 1 GO:0004622 lysophospholipase activity 4/3850 24/18639 0.166666666666667 0.806883116883117 0.761169156175599 1 GO:0005315 phosphate transmembrane transporter activity 4/3850 24/18639 0.166666666666667 0.806883116883117 0.761169156175599 1 GO:0030215 semaphorin receptor binding 4/3850 24/18639 0.166666666666667 0.806883116883117 0.761169156175599 1 GO:0030695 GTPase regulator activity 95/3850 489/18639 0.194274028629857 0.940538602501793 0.767799782694473 1 GO:0001530 lipopolysaccharide binding 7/3850 41/18639 0.170731707317073 0.826563192904656 0.771407898027657 1 GO:0140828 metal cation:monoatomic cation antiporter activity 7/3850 41/18639 0.170731707317073 0.826563192904656 0.771407898027657 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/3850 30/18639 0.166666666666667 0.806883116883117 0.77217452926055 1 GO:0031624 ubiquitin conjugating enzyme binding 5/3850 30/18639 0.166666666666667 0.806883116883117 0.77217452926055 1 GO:0032452 histone demethylase activity 5/3850 30/18639 0.166666666666667 0.806883116883117 0.77217452926055 1 GO:0033612 receptor serine/threonine kinase binding 5/3850 30/18639 0.166666666666667 0.806883116883117 0.77217452926055 1 GO:0098918 structural constituent of synapse 5/3850 30/18639 0.166666666666667 0.806883116883117 0.77217452926055 1 GO:0004222 metalloendopeptidase activity 20/3850 110/18639 0.181818181818182 0.880236127508855 0.77369144476778 1 GO:0060589 nucleoside-triphosphatase regulator activity 95/3850 490/18639 0.193877551020408 0.938619135966075 0.774760974937381 1 GO:0004033 aldo-keto reductase (NADPH) activity 6/3850 36/18639 0.166666666666667 0.806883116883117 0.782989868920632 1 GO:0005484 SNAP receptor activity 6/3850 36/18639 0.166666666666667 0.806883116883117 0.782989868920632 1 GO:0140359 ABC-type transporter activity 8/3850 47/18639 0.170212765957447 0.824050842774247 0.783252430563168 1 GO:0004535 poly(A)-specific ribonuclease activity 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0008417 fucosyltransferase activity 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0017154 semaphorin receptor activity 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0035325 Toll-like receptor binding 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0039706 co-receptor binding 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0046974 histone H3K9 methyltransferase activity 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0061459 L-arginine transmembrane transporter activity 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0071837 HMG box domain binding 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/3850 13/18639 0.153846153846154 0.744815184815185 0.783525426795621 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/3850 19/18639 0.157894736842105 0.764415584415584 0.78401081081215 1 GO:0034987 immunoglobulin receptor binding 3/3850 19/18639 0.157894736842105 0.764415584415584 0.78401081081215 1 GO:0043395 heparan sulfate proteoglycan binding 3/3850 19/18639 0.157894736842105 0.764415584415584 0.78401081081215 1 GO:0070003 threonine-type peptidase activity 3/3850 19/18639 0.157894736842105 0.764415584415584 0.78401081081215 1 GO:0097001 ceramide binding 3/3850 19/18639 0.157894736842105 0.764415584415584 0.78401081081215 1 GO:0120227 acyl-CoA binding 3/3850 19/18639 0.157894736842105 0.764415584415584 0.78401081081215 1 GO:0005319 lipid transporter activity 33/3850 178/18639 0.185393258426966 0.897544141252006 0.78440284697425 1 GO:1902936 phosphatidylinositol bisphosphate binding 20/3850 111/18639 0.18018018018018 0.872306072306072 0.787563597060137 1 GO:0005537 D-mannose binding 4/3850 25/18639 0.16 0.774607792207792 0.789768074946348 1 GO:0015645 fatty acid ligase activity 4/3850 25/18639 0.16 0.774607792207792 0.789768074946348 1 GO:0017025 TBP-class protein binding 4/3850 25/18639 0.16 0.774607792207792 0.789768074946348 1 GO:0120515 fatty acid-CoA ligase activity 4/3850 25/18639 0.16 0.774607792207792 0.789768074946348 1 GO:0017046 peptide hormone binding 9/3850 53/18639 0.169811320754717 0.822107326635628 0.794234320431171 1 GO:0048306 calcium-dependent protein binding 14/3850 80/18639 0.175 0.847227272727273 0.796446994299236 1 GO:0005452 solute:inorganic anion antiporter activity 5/3850 31/18639 0.161290322580645 0.780854629241726 0.797328366932819 1 GO:1990782 protein tyrosine kinase binding 21/3850 117/18639 0.179487179487179 0.868951048951049 0.797739164376466 1 GO:0030414 peptidase inhibitor activity 31/3850 169/18639 0.183431952662722 0.88804887420272 0.798440639987582 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 16/3850 91/18639 0.175824175824176 0.851217354074497 0.802072301732788 1 GO:0072341 modified amino acid binding 16/3850 91/18639 0.175824175824176 0.851217354074497 0.802072301732788 1 GO:0070888 E-box binding 10/3850 59/18639 0.169491525423729 0.820559101915034 0.80444747721418 1 GO:0023023 MHC protein complex binding 6/3850 37/18639 0.162162162162162 0.785075465075465 0.805466631297523 1 GO:0019955 cytokine binding 26/3850 144/18639 0.180555555555556 0.874123376623377 0.808545728509252 1 GO:0005326 neurotransmitter transmembrane transporter activity 3/3850 20/18639 0.15 0.726194805194805 0.813521593951523 1 GO:0010851 cyclase regulator activity 3/3850 20/18639 0.15 0.726194805194805 0.813521593951523 1 GO:0004435 phosphatidylinositol phospholipase C activity 4/3850 26/18639 0.153846153846154 0.744815184815185 0.815551993234049 1 GO:0005112 Notch binding 4/3850 26/18639 0.153846153846154 0.744815184815185 0.815551993234049 1 GO:0008157 protein phosphatase 1 binding 4/3850 26/18639 0.153846153846154 0.744815184815185 0.815551993234049 1 GO:0070412 R-SMAD binding 4/3850 26/18639 0.153846153846154 0.744815184815185 0.815551993234049 1 GO:0005496 steroid binding 19/3850 108/18639 0.175925925925926 0.851709956709957 0.816999646122621 1 GO:0005161 platelet-derived growth factor receptor binding 2/3850 14/18639 0.142857142857143 0.691614100185529 0.818062327514143 1 GO:0005545 1-phosphatidylinositol binding 2/3850 14/18639 0.142857142857143 0.691614100185529 0.818062327514143 1 GO:0019763 immunoglobulin receptor activity 2/3850 14/18639 0.142857142857143 0.691614100185529 0.818062327514143 1 GO:0019992 diacylglycerol binding 2/3850 14/18639 0.142857142857143 0.691614100185529 0.818062327514143 1 GO:0031404 chloride ion binding 2/3850 14/18639 0.142857142857143 0.691614100185529 0.818062327514143 1 GO:1901612 cardiolipin binding 2/3850 14/18639 0.142857142857143 0.691614100185529 0.818062327514143 1 GO:0008378 galactosyltransferase activity 5/3850 32/18639 0.15625 0.756452922077922 0.820241111097469 1 GO:0043425 bHLH transcription factor binding 5/3850 32/18639 0.15625 0.756452922077922 0.820241111097469 1 GO:0071813 lipoprotein particle binding 5/3850 32/18639 0.15625 0.756452922077922 0.820241111097469 1 GO:0071814 protein-lipid complex binding 5/3850 32/18639 0.15625 0.756452922077922 0.820241111097469 1 GO:0120015 sterol transfer activity 5/3850 32/18639 0.15625 0.756452922077922 0.820241111097469 1 GO:0004866 endopeptidase inhibitor activity 29/3850 161/18639 0.180124223602484 0.872035169799145 0.823173114124589 1 GO:0008201 heparin binding 31/3850 172/18639 0.180232558139535 0.872559649652673 0.82892593536104 1 GO:0005044 scavenger receptor activity 4/3850 27/18639 0.148148148148148 0.717229437229437 0.838676385384502 1 GO:0001846 opsonin binding 3/3850 21/18639 0.142857142857143 0.691614100185529 0.839536434737507 1 GO:0061891 calcium ion sensor activity 3/3850 21/18639 0.142857142857143 0.691614100185529 0.839536434737507 1 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 6/3850 39/18639 0.153846153846154 0.744815184815185 0.844920787542175 1 GO:0170055 lipid transmembrane transporter activity 9/3850 56/18639 0.160714285714286 0.77806586270872 0.845271873431012 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0005041 low-density lipoprotein particle receptor activity 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0008242 omega peptidase activity 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0033130 acetylcholine receptor binding 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0034483 heparan sulfate sulfotransferase activity 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0045504 dynein heavy chain binding 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0047372 monoacylglycerol lipase activity 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0140161 monocarboxylate:sodium symporter activity 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0140776 protein-containing complex destabilizing activity 2/3850 15/18639 0.133333333333333 0.645506493506493 0.847571568389089 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 7/3850 45/18639 0.155555555555556 0.753090909090909 0.849609716160991 1 GO:0045499 chemorepellent activity 4/3850 28/18639 0.142857142857143 0.691614100185529 0.85931557629925 1 GO:0046625 sphingolipid binding 4/3850 28/18639 0.142857142857143 0.691614100185529 0.85931557629925 1 GO:0050698 proteoglycan sulfotransferase activity 4/3850 28/18639 0.142857142857143 0.691614100185529 0.85931557629925 1 GO:0051959 dynein light intermediate chain binding 4/3850 28/18639 0.142857142857143 0.691614100185529 0.85931557629925 1 GO:0141052 histone H3 demethylase activity 4/3850 28/18639 0.142857142857143 0.691614100185529 0.85931557629925 1 GO:0008376 acetylgalactosaminyltransferase activity 5/3850 34/18639 0.147058823529412 0.711955691367456 0.859770940926232 1 GO:0008970 phospholipase A1 activity 3/3850 22/18639 0.136363636363636 0.660177095631641 0.862348454453133 1 GO:0140784 metal ion sensor activity 3/3850 22/18639 0.136363636363636 0.660177095631641 0.862348454453133 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 8/3850 52/18639 0.153846153846154 0.744815184815185 0.869213103057442 1 GO:0061631 ubiquitin conjugating enzyme activity 5/3850 35/18639 0.142857142857143 0.691614100185529 0.876633789780453 1 GO:0005416 amino acid:monoatomic cation symporter activity 4/3850 29/18639 0.137931034482759 0.667765338110166 0.877654524895188 1 GO:0016298 lipase activity 22/3850 130/18639 0.169230769230769 0.819296703296703 0.879523197570167 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 11/3850 70/18639 0.157142857142857 0.760775510204082 0.881944583972323 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/3850 23/18639 0.130434782608696 0.631473743647657 0.882256435562859 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/3850 23/18639 0.130434782608696 0.631473743647657 0.882256435562859 1 GO:0016849 phosphorus-oxygen lyase activity 3/3850 23/18639 0.130434782608696 0.631473743647657 0.882256435562859 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/3850 23/18639 0.130434782608696 0.631473743647657 0.882256435562859 1 GO:0140103 catalytic activity, acting on a glycoprotein 3/3850 23/18639 0.130434782608696 0.631473743647657 0.882256435562859 1 GO:0005246 calcium channel regulator activity 8/3850 53/18639 0.150943396226415 0.730762068120559 0.882542664413224 1 GO:0008146 sulfotransferase activity 8/3850 53/18639 0.150943396226415 0.730762068120559 0.882542664413224 1 GO:0051018 protein kinase A binding 8/3850 53/18639 0.150943396226415 0.730762068120559 0.882542664413224 1 GO:0005539 glycosaminoglycan binding 43/3850 242/18639 0.177685950413223 0.860230760974563 0.885720440259651 1 GO:0008307 structural constituent of muscle 6/3850 42/18639 0.142857142857143 0.691614100185529 0.89164282004701 1 GO:0008484 sulfuric ester hydrolase activity 2/3850 17/18639 0.117647058823529 0.569564553093965 0.893884183443528 1 GO:0031489 myosin V binding 2/3850 17/18639 0.117647058823529 0.569564553093965 0.893884183443528 1 GO:0038191 neuropilin binding 2/3850 17/18639 0.117647058823529 0.569564553093965 0.893884183443528 1 GO:0045125 bioactive lipid receptor activity 2/3850 17/18639 0.117647058823529 0.569564553093965 0.893884183443528 1 GO:0046965 nuclear retinoid X receptor binding 2/3850 17/18639 0.117647058823529 0.569564553093965 0.893884183443528 1 GO:0046982 protein heterodimerization activity 67/3850 369/18639 0.181571815718157 0.879043395628761 0.898023446169337 1 GO:0042562 hormone binding 15/3850 94/18639 0.159574468085106 0.772547665100857 0.898524219372157 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/3850 24/18639 0.125 0.605162337662338 0.899554618332468 1 GO:0030552 cAMP binding 3/3850 24/18639 0.125 0.605162337662338 0.899554618332468 1 GO:0035035 histone acetyltransferase binding 3/3850 24/18639 0.125 0.605162337662338 0.899554618332468 1 GO:0016758 hexosyltransferase activity 34/3850 197/18639 0.17258883248731 0.835554090579471 0.900504008245161 1 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0004090 carbonyl reductase (NADPH) activity 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0004382 GDP phosphatase activity 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0005131 growth hormone receptor binding 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0008140 cAMP response element binding protein binding 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0015187 glycine transmembrane transporter activity 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0015203 polyamine transmembrane transporter activity 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0019911 structural constituent of myelin sheath 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0035256 G protein-coupled glutamate receptor binding 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0043121 neurotrophin binding 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0051864 histone H3K36 demethylase activity 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0070513 death domain binding 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0141109 transporter activator activity 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:1905394 retromer complex binding 1/3850 10/18639 0.1 0.48412987012987 0.901169966396802 1 GO:0005096 GTPase activator activity 48/3850 271/18639 0.177121771217712 0.857499400968036 0.901758993031406 1 GO:0022829 wide pore channel activity 5/3850 37/18639 0.135135135135135 0.654229554229554 0.905217494340857 1 GO:0030551 cyclic nucleotide binding 5/3850 37/18639 0.135135135135135 0.654229554229554 0.905217494340857 1 GO:0000149 SNARE binding 17/3850 106/18639 0.160377358490566 0.776434697378094 0.906128536300338 1 GO:0005164 tumor necrosis factor receptor binding 4/3850 31/18639 0.129032258064516 0.624683703393381 0.908186490545874 1 GO:0070273 phosphatidylinositol-4-phosphate binding 4/3850 31/18639 0.129032258064516 0.624683703393381 0.908186490545874 1 GO:0016854 racemase and epimerase activity 2/3850 18/18639 0.111111111111111 0.537922077922078 0.911778390620348 1 GO:0017075 syntaxin-1 binding 2/3850 18/18639 0.111111111111111 0.537922077922078 0.911778390620348 1 GO:0017128 phospholipid scramblase activity 2/3850 18/18639 0.111111111111111 0.537922077922078 0.911778390620348 1 GO:0030228 lipoprotein particle receptor activity 2/3850 18/18639 0.111111111111111 0.537922077922078 0.911778390620348 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/3850 18/18639 0.111111111111111 0.537922077922078 0.911778390620348 1 GO:0050811 GABA receptor binding 2/3850 18/18639 0.111111111111111 0.537922077922078 0.911778390620348 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/3850 25/18639 0.12 0.580955844155844 0.914525510612394 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/3850 25/18639 0.12 0.580955844155844 0.914525510612394 1 GO:0120020 cholesterol transfer activity 3/3850 25/18639 0.12 0.580955844155844 0.914525510612394 1 GO:0048020 CCR chemokine receptor binding 7/3850 50/18639 0.14 0.677781818181818 0.915350690490111 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 21/3850 130/18639 0.161538461538462 0.782055944055944 0.919768396723196 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/3850 11/18639 0.0909090909090909 0.440118063754427 0.921594875375938 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/3850 11/18639 0.0909090909090909 0.440118063754427 0.921594875375938 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/3850 11/18639 0.0909090909090909 0.440118063754427 0.921594875375938 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/3850 11/18639 0.0909090909090909 0.440118063754427 0.921594875375938 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/3850 11/18639 0.0909090909090909 0.440118063754427 0.921594875375938 1 GO:0042608 T cell receptor binding 1/3850 11/18639 0.0909090909090909 0.440118063754427 0.921594875375938 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/3850 11/18639 0.0909090909090909 0.440118063754427 0.921594875375938 1 GO:0008009 chemokine activity 6/3850 45/18639 0.133333333333333 0.645506493506493 0.925794548066552 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/3850 19/18639 0.105263157894737 0.50961038961039 0.926809870597783 1 GO:0005229 intracellularly calcium-gated chloride channel activity 2/3850 19/18639 0.105263157894737 0.50961038961039 0.926809870597783 1 GO:0016918 retinal binding 2/3850 19/18639 0.105263157894737 0.50961038961039 0.926809870597783 1 GO:0030506 ankyrin binding 2/3850 19/18639 0.105263157894737 0.50961038961039 0.926809870597783 1 GO:0042577 lipid phosphatase activity 2/3850 19/18639 0.105263157894737 0.50961038961039 0.926809870597783 1 GO:0141147 intracellularly calcium-gated channel activity 2/3850 19/18639 0.105263157894737 0.50961038961039 0.926809870597783 1 GO:1990380 K48-linked deubiquitinase activity 2/3850 19/18639 0.105263157894737 0.50961038961039 0.926809870597783 1 GO:0015291 secondary active transmembrane transporter activity 50/3850 287/18639 0.174216027874564 0.843431829494547 0.927018976241399 1 GO:0051139 metal cation:proton antiporter activity 3/3850 26/18639 0.115384615384615 0.558611388611389 0.927435099835656 1 GO:0019956 chemokine binding 4/3850 33/18639 0.121212121212121 0.586824085005903 0.931747930678636 1 GO:0030296 protein tyrosine kinase activator activity 4/3850 33/18639 0.121212121212121 0.586824085005903 0.931747930678636 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 19/3850 122/18639 0.155737704918033 0.753972748562913 0.937708592217317 1 GO:0004000 adenosine deaminase activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0004126 cytidine deaminase activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0005025 transforming growth factor beta receptor activity, type I 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0005026 transforming growth factor beta receptor activity, type II 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0005078 MAP-kinase scaffold activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0005247 voltage-gated chloride channel activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0005436 sodium:phosphate symporter activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0015166 polyol transmembrane transporter activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0016361 activin receptor activity, type I 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0016362 activin receptor activity, type II 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0017002 activin receptor activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0031543 peptidyl-proline dioxygenase activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0035197 siRNA binding 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0140900 chloride:bicarbonate antiporter activity 1/3850 12/18639 0.0833333333333333 0.403441558441558 0.937799499050119 1 GO:0005385 zinc ion transmembrane transporter activity 3/3850 27/18639 0.111111111111111 0.537922077922078 0.93852993914205 1 GO:0015252 proton channel activity 3/3850 27/18639 0.111111111111111 0.537922077922078 0.93852993914205 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/3850 20/18639 0.1 0.48412987012987 0.939397456891812 1 GO:0030627 pre-mRNA 5'-splice site binding 2/3850 20/18639 0.1 0.48412987012987 0.939397456891812 1 GO:0031418 L-ascorbic acid binding 2/3850 20/18639 0.1 0.48412987012987 0.939397456891812 1 GO:0015459 potassium channel regulator activity 8/3850 59/18639 0.135593220338983 0.656447281532027 0.940811765996806 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/3850 34/18639 0.117647058823529 0.569564553093965 0.941344862645623 1 GO:0051427 hormone receptor binding 4/3850 34/18639 0.117647058823529 0.569564553093965 0.941344862645623 1 GO:0001540 amyloid-beta binding 12/3850 83/18639 0.144578313253012 0.699946800187764 0.942729072589463 1 GO:0005504 fatty acid binding 6/3850 47/18639 0.127659574468085 0.618038132080685 0.942927783907196 1 GO:0004867 serine-type endopeptidase inhibitor activity 14/3850 95/18639 0.147368421052632 0.713454545454545 0.945044178732646 1 GO:0016247 channel regulator activity 27/3850 168/18639 0.160714285714286 0.77806586270872 0.945361288288324 1 GO:0042287 MHC protein binding 5/3850 41/18639 0.121951219512195 0.590402280646183 0.945516501735596 1 GO:0051393 alpha-actinin binding 3/3850 28/18639 0.107142857142857 0.518710575139147 0.948035662683186 1 GO:0010314 phosphatidylinositol-5-phosphate binding 2/3850 21/18639 0.0952380952380952 0.461076066790353 0.94990914343437 1 GO:0015174 basic amino acid transmembrane transporter activity 2/3850 21/18639 0.0952380952380952 0.461076066790353 0.94990914343437 1 GO:0051428 peptide hormone receptor binding 2/3850 21/18639 0.0952380952380952 0.461076066790353 0.94990914343437 1 GO:0032266 phosphatidylinositol-3-phosphate binding 6/3850 48/18639 0.125 0.605162337662338 0.9500895747498 1 GO:0004465 lipoprotein lipase activity 1/3850 13/18639 0.0769230769230769 0.372407592407592 0.950655671737993 1 GO:0070123 transforming growth factor beta receptor activity, type III 1/3850 13/18639 0.0769230769230769 0.372407592407592 0.950655671737993 1 GO:0089720 caspase binding 1/3850 13/18639 0.0769230769230769 0.372407592407592 0.950655671737993 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 29/3850 181/18639 0.160220994475138 0.775677692473273 0.952964555204933 1 GO:0141108 transporter regulator activity 27/3850 170/18639 0.158823529411765 0.768912146676852 0.953085884353251 1 GO:0035250 UDP-galactosyltransferase activity 3/3850 29/18639 0.103448275862069 0.500824003582624 0.956156563197186 1 GO:0001222 transcription corepressor binding 6/3850 49/18639 0.122448979591837 0.59281208587331 0.956431123634646 1 GO:0045505 dynein intermediate chain binding 4/3850 36/18639 0.111111111111111 0.537922077922078 0.956939307313636 1 GO:0099106 ion channel regulator activity 25/3850 160/18639 0.15625 0.756452922077922 0.95699454075824 1 GO:0001221 transcription coregulator binding 17/3850 115/18639 0.147826086956522 0.715670242800678 0.957744084401971 1 GO:0015377 chloride:monoatomic cation symporter activity 2/3850 22/18639 0.0909090909090909 0.440118063754427 0.958665212332494 1 GO:0004065 arylsulfatase activity 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0004705 JUN kinase activity 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0008195 phosphatidate phosphatase activity 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0008331 high voltage-gated calcium channel activity 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0008392 arachidonate epoxygenase activity 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0032454 histone H3K9 demethylase activity 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0034236 protein kinase A catalytic subunit binding 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0042043 neurexin family protein binding 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0044548 S100 protein binding 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0098821 BMP receptor activity 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:1901474 azole transmembrane transporter activity 1/3850 14/18639 0.0714285714285714 0.345807050092764 0.960855159755213 1 GO:0032813 tumor necrosis factor receptor superfamily binding 6/3850 50/18639 0.12 0.580955844155844 0.962033000881628 1 GO:0070851 growth factor receptor binding 21/3850 139/18639 0.151079136690647 0.731419228253761 0.962037741228948 1 GO:0140767 enzyme-substrate adaptor activity 21/3850 139/18639 0.151079136690647 0.731419228253761 0.962037741228948 1 GO:0048019 receptor antagonist activity 3/3850 30/18639 0.1 0.48412987012987 0.963075935048953 1 GO:0030547 signaling receptor inhibitor activity 5/3850 44/18639 0.113636363636364 0.550147579693034 0.964762082374555 1 GO:0016757 glycosyltransferase activity 44/3850 267/18639 0.164794007490637 0.797817014446228 0.964793365332622 1 GO:0001217 DNA-binding transcription repressor activity 46/3850 278/18639 0.165467625899281 0.801078202373166 0.965194518693347 1 GO:0005283 amino acid:sodium symporter activity 2/3850 23/18639 0.0869565217391304 0.420982495765104 0.965942238691507 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/3850 23/18639 0.0869565217391304 0.420982495765104 0.965942238691507 1 GO:0016597 amino acid binding 6/3850 51/18639 0.117647058823529 0.569564553093965 0.966970190737442 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 44/3850 268/18639 0.164179104477612 0.794840085287847 0.96704201941514 1 GO:0005501 retinoid binding 4/3850 38/18639 0.105263157894737 0.50961038961039 0.968620540922512 1 GO:0019840 isoprenoid binding 4/3850 38/18639 0.105263157894737 0.50961038961039 0.968620540922512 1 GO:0004089 carbonate dehydratase activity 1/3850 15/18639 0.0666666666666667 0.322753246753247 0.968946844852793 1 GO:0015250 water channel activity 1/3850 15/18639 0.0666666666666667 0.322753246753247 0.968946844852793 1 GO:0015929 hexosaminidase activity 1/3850 15/18639 0.0666666666666667 0.322753246753247 0.968946844852793 1 GO:0008514 organic anion transmembrane transporter activity 44/3850 269/18639 0.163568773234201 0.791885289431758 0.969165521146438 1 GO:0004806 triacylglycerol lipase activity 2/3850 24/18639 0.0833333333333333 0.403441558441558 0.971977476905965 1 GO:0005506 iron ion binding 23/3850 154/18639 0.149350649350649 0.723051104739416 0.972404303438136 1 GO:0015171 amino acid transmembrane transporter activity 14/3850 102/18639 0.137254901960784 0.664491978609626 0.97312359465801 1 GO:0004180 carboxypeptidase activity 5/3850 46/18639 0.108695652173913 0.526228119706381 0.973873663576945 1 GO:0042379 chemokine receptor binding 9/3850 72/18639 0.125 0.605162337662338 0.974404117949492 1 GO:0004707 MAP kinase activity 1/3850 16/18639 0.0625 0.302581168831169 0.975366230984491 1 GO:0005024 transforming growth factor beta receptor activity 1/3850 16/18639 0.0625 0.302581168831169 0.975366230984491 1 GO:0008391 arachidonate monooxygenase activity 1/3850 16/18639 0.0625 0.302581168831169 0.975366230984491 1 GO:0015378 sodium:chloride symporter activity 1/3850 16/18639 0.0625 0.302581168831169 0.975366230984491 1 GO:0015385 sodium:proton antiporter activity 1/3850 16/18639 0.0625 0.302581168831169 0.975366230984491 1 GO:0019841 retinol binding 1/3850 16/18639 0.0625 0.302581168831169 0.975366230984491 1 GO:0022841 potassium ion leak channel activity 1/3850 16/18639 0.0625 0.302581168831169 0.975366230984491 1 GO:0034450 ubiquitin-ubiquitin ligase activity 1/3850 16/18639 0.0625 0.302581168831169 0.975366230984491 1 GO:0001848 complement binding 2/3850 25/18639 0.08 0.387303896103896 0.976973300061927 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/3850 25/18639 0.08 0.387303896103896 0.976973300061927 1 GO:0042974 nuclear retinoic acid receptor binding 2/3850 25/18639 0.08 0.387303896103896 0.976973300061927 1 GO:0030246 carbohydrate binding 45/3850 280/18639 0.160714285714286 0.77806586270872 0.97887076828922 1 GO:0008429 phosphatidylethanolamine binding 1/3850 17/18639 0.0588235294117647 0.284782276546982 0.980458858955801 1 GO:0008569 minus-end-directed microtubule motor activity 1/3850 17/18639 0.0588235294117647 0.284782276546982 0.980458858955801 1 GO:0015278 intracellularly gated calcium channel activity 1/3850 17/18639 0.0588235294117647 0.284782276546982 0.980458858955801 1 GO:0016805 dipeptidase activity 1/3850 17/18639 0.0588235294117647 0.284782276546982 0.980458858955801 1 GO:0036041 long-chain fatty acid binding 1/3850 17/18639 0.0588235294117647 0.284782276546982 0.980458858955801 1 GO:0045236 CXCR chemokine receptor binding 1/3850 17/18639 0.0588235294117647 0.284782276546982 0.980458858955801 1 GO:0017171 serine hydrolase activity 30/3850 198/18639 0.151515151515152 0.733530106257379 0.980882334891264 1 GO:0005160 transforming growth factor beta receptor binding 2/3850 26/18639 0.0769230769230769 0.372407592407592 0.981101483414117 1 GO:0005227 calcium-activated cation channel activity 2/3850 26/18639 0.0769230769230769 0.372407592407592 0.981101483414117 1 GO:0019865 immunoglobulin binding 2/3850 26/18639 0.0769230769230769 0.372407592407592 0.981101483414117 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/3850 34/18639 0.0882352941176471 0.427173414820474 0.981726542904442 1 GO:0046943 carboxylic acid transmembrane transporter activity 28/3850 188/18639 0.148936170212766 0.721044487427466 0.982921502741979 1 GO:0008236 serine-type peptidase activity 29/3850 194/18639 0.149484536082474 0.723699290400321 0.983370369078022 1 GO:0005342 organic acid transmembrane transporter activity 28/3850 189/18639 0.148148148148148 0.717229437229437 0.984332703898779 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/3850 18/18639 0.0555555555555556 0.268961038961039 0.984498886504946 1 GO:0005372 water transmembrane transporter activity 1/3850 18/18639 0.0555555555555556 0.268961038961039 0.984498886504946 1 GO:0015373 monoatomic anion:sodium symporter activity 1/3850 18/18639 0.0555555555555556 0.268961038961039 0.984498886504946 1 GO:0008395 steroid hydroxylase activity 2/3850 27/18639 0.0740740740740741 0.358614718614719 0.984507206955882 1 GO:0005343 organic acid:sodium symporter activity 3/3850 35/18639 0.0857142857142857 0.414968460111317 0.984729530192434 1 GO:0004175 endopeptidase activity 67/3850 405/18639 0.165432098765432 0.800906204906205 0.985186610229743 1 GO:0008375 acetylglucosaminyltransferase activity 4/3850 43/18639 0.0930232558139535 0.45035336756267 0.986171613542041 1 GO:0004896 cytokine receptor activity 12/3850 96/18639 0.125 0.605162337662338 0.986593011248871 1 GO:0004190 aspartic-type endopeptidase activity 3/3850 36/18639 0.0833333333333333 0.403441558441558 0.987255914090506 1 GO:0022821 solute:potassium antiporter activity 1/3850 19/18639 0.0526315789473684 0.254805194805195 0.987703831833121 1 GO:0022840 leak channel activity 1/3850 19/18639 0.0526315789473684 0.254805194805195 0.987703831833121 1 GO:0022842 narrow pore channel activity 1/3850 19/18639 0.0526315789473684 0.254805194805195 0.987703831833121 1 GO:0042834 peptidoglycan binding 1/3850 19/18639 0.0526315789473684 0.254805194805195 0.987703831833121 1 GO:0004252 serine-type endopeptidase activity 25/3850 176/18639 0.142045454545455 0.687684474616293 0.989357327568773 1 GO:0042805 actinin binding 3/3850 37/18639 0.0810810810810811 0.392537732537733 0.989377734335815 1 GO:0070001 aspartic-type peptidase activity 3/3850 37/18639 0.0810810810810811 0.392537732537733 0.989377734335815 1 GO:0005543 phospholipid binding 83/3850 497/18639 0.167002012072435 0.808506624160548 0.989607797272164 1 GO:0004181 metallocarboxypeptidase activity 2/3850 29/18639 0.0689655172413793 0.333882669055083 0.989620573114384 1 GO:0003730 mRNA 3'-UTR binding 40/3850 262/18639 0.152671755725191 0.739129572717359 0.989712798084132 1 GO:0042605 peptide antigen binding 4/3850 45/18639 0.0888888888888889 0.430337662337662 0.990134961048617 1 GO:0001972 retinoic acid binding 1/3850 20/18639 0.05 0.242064935064935 0.990246272619506 1 GO:0005126 cytokine receptor binding 42/3850 275/18639 0.152727272727273 0.739398347107438 0.991046522975857 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/3850 30/18639 0.0666666666666667 0.322753246753247 0.991516618690486 1 GO:0022839 monoatomic ion-gated channel activity 2/3850 30/18639 0.0666666666666667 0.322753246753247 0.991516618690486 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4/3850 46/18639 0.0869565217391304 0.420982495765104 0.991683656045919 1 GO:0005123 death receptor binding 1/3850 21/18639 0.0476190476190476 0.230538033395176 0.992263129078763 1 GO:0005248 voltage-gated sodium channel activity 1/3850 21/18639 0.0476190476190476 0.230538033395176 0.992263129078763 1 GO:0008373 sialyltransferase activity 1/3850 21/18639 0.0476190476190476 0.230538033395176 0.992263129078763 1 GO:0015125 bile acid transmembrane transporter activity 1/3850 21/18639 0.0476190476190476 0.230538033395176 0.992263129078763 1 GO:0036122 BMP binding 1/3850 21/18639 0.0476190476190476 0.230538033395176 0.992263129078763 1 GO:0015026 coreceptor activity 6/3850 61/18639 0.0983606557377049 0.476193314881839 0.992440126847589 1 GO:0042277 peptide binding 37/3850 249/18639 0.14859437751004 0.719389766859646 0.992528975842419 1 GO:0033691 sialic acid binding 1/3850 22/18639 0.0454545454545455 0.220059031877214 0.993863029876204 1 GO:0015144 carbohydrate transmembrane transporter activity 3/3850 40/18639 0.075 0.363097402597403 0.993891939351161 1 GO:0015106 bicarbonate transmembrane transporter activity 2/3850 32/18639 0.0625 0.302581168831169 0.994347697962265 1 GO:0016493 C-C chemokine receptor activity 1/3850 23/18639 0.0434782608695652 0.210491247882552 0.995132156748236 1 GO:0019239 deaminase activity 2/3850 33/18639 0.0606060606060606 0.293412042502952 0.995391842768228 1 GO:0015149 hexose transmembrane transporter activity 1/3850 24/18639 0.0416666666666667 0.201720779220779 0.996138881958769 1 GO:0019957 C-C chemokine binding 1/3850 24/18639 0.0416666666666667 0.201720779220779 0.996138881958769 1 GO:0055056 D-glucose transmembrane transporter activity 1/3850 24/18639 0.0416666666666667 0.201720779220779 0.996138881958769 1 GO:0004497 monooxygenase activity 12/3850 106/18639 0.113207547169811 0.548071551090419 0.996149253824436 1 GO:0015020 glucuronosyltransferase activity 2/3850 34/18639 0.0588235294117647 0.284782276546982 0.996245924009715 1 GO:0001786 phosphatidylserine binding 5/3850 59/18639 0.0847457627118644 0.410279550957517 0.996740160078897 1 GO:0015271 outward rectifier potassium channel activity 1/3850 25/18639 0.04 0.193651948051948 0.996937447871138 1 GO:0015294 solute:monoatomic cation symporter activity 13/3850 116/18639 0.112068965517241 0.54255933721451 0.997553322294134 1 GO:0005544 calcium-dependent phospholipid binding 4/3850 53/18639 0.0754716981132075 0.365381034060279 0.997561707882802 1 GO:0001637 G protein-coupled chemoattractant receptor activity 1/3850 26/18639 0.0384615384615385 0.186203796203796 0.997570886449419 1 GO:0004950 chemokine receptor activity 1/3850 26/18639 0.0384615384615385 0.186203796203796 0.997570886449419 1 GO:0015145 monosaccharide transmembrane transporter activity 1/3850 26/18639 0.0384615384615385 0.186203796203796 0.997570886449419 1 GO:0008083 growth factor activity 20/3850 162/18639 0.123456790123457 0.597691197691198 0.997981942006881 1 GO:0031406 carboxylic acid binding 24/3850 187/18639 0.128342245989305 0.62134314882978 0.998069848691416 1 GO:0005104 fibroblast growth factor receptor binding 1/3850 27/18639 0.037037037037037 0.179307359307359 0.998073335660708 1 GO:0008194 UDP-glycosyltransferase activity 17/3850 145/18639 0.117241379310345 0.567600537393641 0.998376576792242 1 GO:0043177 organic acid binding 24/3850 189/18639 0.126984126984127 0.614768089053803 0.998444846164064 1 GO:0051119 sugar transmembrane transporter activity 1/3850 28/18639 0.0357142857142857 0.172903525046382 0.998471877338458 1 GO:0015293 symporter activity 17/3850 146/18639 0.116438356164384 0.563712862479986 0.998562921021846 1 GO:0015370 solute:sodium symporter activity 7/3850 79/18639 0.0886075949367089 0.42897583429229 0.998618327427864 1 GO:0099604 ligand-gated calcium channel activity 1/3850 29/18639 0.0344827586206897 0.166941334527541 0.99878799534646 1 GO:0005253 monoatomic anion channel activity 10/3850 103/18639 0.0970873786407767 0.470029000126088 0.999086066333784 1 GO:0001664 G protein-coupled receptor binding 41/3850 297/18639 0.138047138047138 0.668327430145612 0.999173105906015 1 GO:0005184 neuropeptide hormone activity 1/3850 31/18639 0.032258064516129 0.156170925848345 0.999237608284274 1 GO:0005254 chloride channel activity 7/3850 83/18639 0.0843373493975904 0.408302300109529 0.999272607419143 1 GO:0015103 inorganic anion transmembrane transporter activity 19/3850 165/18639 0.115151515151515 0.557482880755608 0.999327989631652 1 GO:0160041 neuropeptide activity 1/3850 32/18639 0.03125 0.151290584415584 0.999395347326919 1 GO:0005245 voltage-gated calcium channel activity 2/3850 43/18639 0.0465116279069767 0.225176683781335 0.99942324063232 1 GO:0015085 calcium ion transmembrane transporter activity 16/3850 147/18639 0.108843537414966 0.526944076331831 0.99944061063973 1 GO:0008509 monoatomic anion transmembrane transporter activity 16/3850 149/18639 0.10738255033557 0.51987100148174 0.999569322657971 1 GO:0033293 monocarboxylic acid binding 6/3850 79/18639 0.0759493670886076 0.367693572250534 0.999599609496607 1 GO:0099095 ligand-gated monoatomic anion channel activity 2/3850 47/18639 0.0425531914893617 0.206012710693562 0.999752439449114 1 GO:0038187 pattern recognition receptor activity 2/3850 48/18639 0.0416666666666667 0.201720779220779 0.999799829430398 1 GO:0140375 immune receptor activity 16/3850 156/18639 0.102564102564103 0.496543456543457 0.999831102832326 1 GO:0005179 hormone activity 12/3850 132/18639 0.0909090909090909 0.440118063754427 0.999899717970208 1 GO:0071855 neuropeptide receptor binding 1/3850 40/18639 0.025 0.121032467532468 0.999905396069389 1 GO:0015108 chloride transmembrane transporter activity 10/3850 121/18639 0.0826446280991736 0.400107330685843 0.999941716601158 1 GO:0001216 DNA-binding transcription activator activity 69/3850 491/18639 0.140529531568228 0.680345438675378 0.999947780018775 1 GO:0015081 sodium ion transmembrane transporter activity 15/3850 164/18639 0.0914634146341463 0.442801710484637 0.99997953712597 1 GO:0005125 cytokine activity 25/3850 234/18639 0.106837606837607 0.517232767232767 0.999984408736199 1 GO:0008188 neuropeptide receptor activity 1/3850 48/18639 0.0208333333333333 0.10086038961039 0.999985211561791 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 65/3850 484/18639 0.134297520661157 0.650174412364495 0.999988450081651 1 GO:0005272 sodium channel activity 1/3850 51/18639 0.0196078431372549 0.0949274255156608 0.999992628148272 1 GO:0001653 peptide receptor activity 9/3850 128/18639 0.0703125 0.340403814935065 0.999994819334229 1 GO:0005262 calcium channel activity 9/3850 131/18639 0.0687022900763359 0.332608307722812 0.999996903819163 1 GO:0008528 G protein-coupled peptide receptor activity 7/3850 122/18639 0.0573770491803279 0.277779433681073 0.999999195483374 1 GO:0005249 voltage-gated potassium channel activity 2/3850 98/18639 0.0204081632653061 0.0988020143122184 0.999999996453178 1 GO:0030527 structural constituent of chromatin 2/3850 98/18639 0.0204081632653061 0.0988020143122184 0.999999996453178 1 GO:0005244 voltage-gated monoatomic ion channel activity 9/3850 173/18639 0.0520231213872832 0.251859470009759 0.999999998418411 1 GO:0022832 voltage-gated channel activity 9/3850 175/18639 0.0514285714285714 0.24898107606679 0.999999998913224 1 GO:0015079 potassium ion transmembrane transporter activity 7/3850 160/18639 0.04375 0.211806818181818 0.999999999427954 1 GO:0022843 voltage-gated monoatomic cation channel activity 5/3850 143/18639 0.034965034965035 0.169276178367087 0.999999999670307 1 GO:0005267 potassium channel activity 3/3850 124/18639 0.0241935483870968 0.117128194386259 0.999999999825876 1 GO:0099094 ligand-gated monoatomic cation channel activity 4/3850 136/18639 0.0294117647058824 0.142391138273491 0.999999999846313 1 GO:0003823 antigen binding 7/3850 174/18639 0.0402298850574713 0.194764890282132 0.999999999964113 1 GO:0046873 metal ion transmembrane transporter activity 41/3850 450/18639 0.0911111111111111 0.441096103896104 0.999999999993103 1 GO:0015276 ligand-gated monoatomic ion channel activity 5/3850 186/18639 0.0268817204301075 0.130142438206954 0.999999999999959 1 GO:0022834 ligand-gated channel activity 5/3850 188/18639 0.0265957446808511 0.128757944183476 0.999999999999973 1 GO:0005261 monoatomic cation channel activity 19/3850 341/18639 0.0557184750733138 0.269749781010778 1 1 GO:0005216 monoatomic ion channel activity 28/3850 448/18639 0.0625 0.302581168831169 1 1 GO:0022836 gated channel activity 15/3850 318/18639 0.0471698113207547 0.228363146287675 1 1 GO:0030371 translation repressor activity 7/3850 329/18639 0.0212765957446809 0.103006355346781 1 1 GO:0045182 translation regulator activity 16/3850 356/18639 0.0449438202247191 0.217586458485335 1 1