category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	51/554	268/9376	3.22064766420605	CALM3/HSPA5/PSMA7/TUBA1B/CALM1/TUBA1C/NDUFA4/GNAS/TUBB4B/NDUFV3/COX5B/UQCRH/PSMB2/COX6C/COX5A/PSMB6/PARK7/TUBB/PSMA4/UBE2L3/PSMB3/PSMB1/TUBB6/MT-CO3/VDAC2/PSMD8/COX7A1/NDUFC1/NDUFS8/COX7C/NDUFA3/PSMB5/PSMD11/SLC25A6/PSMD4/COX8C/PSMA3/ADRM1/PSMD3/NDUFV2/TUBA1A/SLC39A4/TXN2/PSMD2/XBP1/NDUFA6/PSMB4/NDUFS5/PSMA1/SNCA/CASP9	9.24256550427877
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	49/554	275/9376	3.01558254020348	CYBA/HSPA5/PSMA7/TUBA1B/TUBA1C/NDUFA4/TUBB4B/NDUFV3/COX5B/UQCRH/PSMB2/RAC1/COX6C/COX5A/PSMB6/TUBB/PSMA4/PSMB3/PSMB1/TUBB6/MT-CO3/VDAC2/PSMD8/CAV1/COX7A1/NDUFC1/NDUFS8/COX7C/NDUFA3/PSMB5/PSMD11/SLC25A6/PSMD4/COX8C/PSMA3/ADRM1/PSMD3/NDUFV2/TUBA1A/NCF1/PSMD2/MAPK13/NDUFA6/CREB3/PSMB4/NDUFS5/PSMA1/CREB3L1/CASP9	8.50118312052227
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	18/554	46/9376	6.62250824046461	PSMA7/PSMB2/POMP/PSMB6/PSMA4/PSMB3/PSMB1/PSMD8/PSMB5/PSMD11/PSMD4/PSMA3/ADRM1/PSMD3/PSMD2/PSMB4/PSMA1/PSME3	9.57911061755837
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	49/554	308/9376	2.69248441089596	PSMA7/TUBA1B/TUBA1C/NDUFA4/TUBB4B/NDUFV3/COX5B/UQCRH/TGM2/PSMB2/COX6C/COX5A/PSMB6/TUBB/PSMA4/PSMB3/PSMB1/TUBB6/MT-CO3/VDAC2/PSMD8/COX7A1/NDUFC1/NDUFS8/COX7C/SLC1A2/NDUFA3/PSMB5/PSMD11/SLC25A6/AP2A1/PSMD4/COX8C/PSMA3/ADRM1/PSMD3/NDUFV2/TUBA1A/ACTR1B/PSMD2/POLR2F/NDUFA6/CREB3/PSMB4/NDUFS5/POLR2I/PSMA1/CREB3L1/CASP9	7.568351144042
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	54/554	388/9376	2.35542818861885	GAPDH/CALM3/PSMA7/TUBA1B/CALM1/TUBA1C/NDUFA4/TUBB4B/NDUFV3/COX5B/HSD17B10/UQCRH/DKK1/PSMB2/COX6C/COX5A/PSMB6/TUBB/PSMA4/PSMB3/PSMB1/TUBB6/MT-CO3/VDAC2/PSMD8/COX7A1/NDUFC1/NDUFS8/COX7C/NDUFA3/PSMB5/PSMD11/SLC25A6/PSMD4/COX8C/PSMA3/ADRM1/MAP2K2/PSMD3/NDUFV2/TUBA1A/SLC39A4/WNT2/PSMD2/XBP1/NDUFA6/APP/WNT3A/PSMB4/NDUFS5/PSMA1/SNCA/CASP9/BRAF	6.83310096921169
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	20/554	75/9376	4.51311672683514	PGK1/GAPDH/TPI1/PKM/CBS/ENO1/PHGDH/TALDO1/TKT/GPT2/ALDOA/IDH2/ARG2/PGAM4/PRPS2/ACO2/ALDOC/RPE/IDH3A/GOT1	7.65447454698093
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	25/554	116/9376	3.64745425121374	PGK1/GAPDH/TPI1/PKM/ENO1/PHGDH/TALDO1/TKT/GPT2/ADH5/ALDOA/IDH2/MDH2/GPI/PGAM4/PRPS2/ACO2/ALDOC/DLD/SUCLG2/RPE/IDH3A/ACAT2/GOT1/PCCA	7.18967003553505
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	60/554	480/9376	2.11552346570397	CALM3/HSPA5/PSMA7/TUBA1B/CALM1/TUBA1C/NDUFA4/TUBB4B/NDUFV3/COX5B/HSD17B10/UQCRH/DKK1/PSMB2/RAC1/COX6C/COX5A/PSMB6/PARK7/TUBB/PSMA4/UBE2L3/PSMB3/PSMB1/TUBB6/MT-CO3/VDAC2/PSMD8/COX7A1/NDUFC1/NDUFS8/COX7C/VCP/NDUFA3/PSMB5/PSMD11/SLC25A6/PSMD4/COX8C/PSMA3/ADRM1/MAP2K2/PSMD3/NDUFV2/TUBA1A/WNT2/ACTR1B/PSMD2/XBP1/MAPK13/NDUFA6/APP/WNT3A/PSMB4/NDUFS5/PSMA1/SNCA/CASP9/WDR41/BRAF	6.28722403165368
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	50/554	368/9376	2.2994820279391	HSPA5/PSMA7/TUBA1B/TUBA1C/NDUFA4/ACTB/TUBB4B/NDUFV3/ACTG1/COX5B/UQCRH/PSMB2/RAC1/COX6C/COX5A/PSMB6/TUBB/PSMA4/PSMB3/PSMB1/TUBB6/MT-CO3/PSMD8/COX7A1/NDUFC1/NDUFS8/COX7C/VCP/SLC1A2/NDUFA3/PSMB5/PSMD11/PSMD4/COX8C/PSMA3/ADRM1/PSMD3/NDUFV2/TUBA1A/ACTR1B/PSMD2/XBP1/MAPK13/NDUFA6/PSMB4/NDUFS5/ALYREF/PSMA1/CASP9/WDR41	6.37289835812285
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	33/554	205/9376	2.72438143876024	COL1A1/COL3A1/CYBA/GAPDH/NDUFA4/COL1A2/MMP2/NDUFV3/COX5B/UQCRH/RAC1/COX6C/COX5A/MT-CO3/REN/VDAC2/COX7A1/NDUFC1/NDUFS8/COX7C/PTEN/NDUFA3/SLC25A6/COX8C/PPP1CA/MPC2/NDUFV2/NCF1/MAPK13/NDUFA6/NDUFS5/SLC2A1/PDK3	6.2554551852886
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	27/554	174/9376	2.62616706087389	CALR/HSPA5/PDIA6/PDIA3/LMAN1/SSR2/SSR3/OSTC/HSP90B1/SEC61B/CKAP4/LMAN2/SSR4/DAD1/ERP29/DNAJC3/PDIA4/VCP/DNAJB11/CRYAB/KRTCAP2/SAR1A/XBP1/UBXN6/DDOST/NPLOC4/TUSC3	5.42569858205953
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	32/554	227/9376	2.38578857806263	MGST1/CYBA/NDUFA4/NDUFV3/COX5B/UQCRH/CBR1/RAC1/COX6C/COX5A/GRB2/MT-CO3/VDAC2/ACP1/COX7A1/NDUFC1/NDUFS8/COX7C/PTEN/NDUFA3/SLC25A6/COX8C/MAP2K2/NDUFV2/NCF1/MAPK13/NDUFA6/NDUFS5/BRAF/PRKD3/HGF/SLC26A1	5.29639157571046
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/554	67/9376	3.78899725200711	PGK1/LDHA/GAPDH/TPI1/PKM/ENO1/ADH5/ALDOA/LDHB/GPI/PGAM4/ALDOC/ALDH1B1/DLD/ALDH2	5.74104520343567
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	32/554	233/9376	2.32435196231853	COL1A1/COL3A1/TPM2/DCN/COL1A2/ACTB/COL6A2/ENO1/ACTG1/VCAN/COL6A3/TPM4/COL6A1/MYL4/MYL9/COL5A2/TNNT1/LMOD1/COL5A1/MYL3/NID2/THBS1/FLNC/ATP1B3/CAPZB/LAMA2/ITGA1/EMD/FBLN2/SDC3/SPTAN1/NID1	5.12972417620526
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/554	203/9376	2.41774110366168	COL1A1/COL1A2/ACTB/COL6A2/ACTG1/COL6A3/COL6A1/RAC1/CDC42/MYL9/GRB2/LAMA4/CAV1/PTEN/CCND2/IGF1/PPP1CA/THBS1/TNXB/LAMB2/ACTN1/LAMA2/ITGA1/LAMC3/ELK1/BRAF/HGF/LAMB1/RAC3	5.11736326015868
NA	NA	hsa04518	Integrin signaling	24/554	154/9376	2.63753574944911	COL1A1/COL1A2/ACTB/COL6A2/ACTG1/COL6A3/COL6A1/RAC1/CDC42/FERMT2/LAMA4/CCND2/IGF1/THBS1/TNXB/LAMB2/ACTN1/LAMA2/ITGA1/C3/LAMC3/HGF/LAMB1/RAC3	5.13446958147081
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/554	138/9376	2.69805891278188	NDUFA4/NDUFV3/COX5B/UQCRH/PPA1/ATP6V1F/COX6C/COX5A/ATP6V1B1/MT-CO3/COX7A1/NDUFC1/NDUFS8/COX7C/NDUFA3/COX8C/NDUFV2/NDUFA6/NDUFS5/TCIRG1/COX15/COX11	5.03570536255652
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/554	155/9376	2.51133108186794	HLA-C/HLA-G/CYBA/CALR/TUBA1B/TUBA1C/ACTB/TUBB4B/ACTG1/C1R/SEC61B/ATP6V1F/RAC1/TUBB/TUBB6/ATP6V1B1/THBS1/TUBA1A/NCF1/COLEC12/TCIRG1/C3/COLEC11	4.75437513586097
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/554	31/9376	4.91347385582858	HSPA5/SPCS3/SEC11C/SEC11A/SEC61B/SRP14/SRP72/SPCS1/SRP68	5.46903401797048
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	22/554	157/9376	2.37154222906942	LEP/NDUFA4/NDUFV3/COX5B/UQCRH/SOCS3/RAC1/COX6C/COX5A/CDC42/MT-CO3/COX7A1/NDUFC1/NDUFS8/COX7C/NDUFA3/COX8C/NDUFV2/XBP1/MAPK13/NDUFA6/NDUFS5	4.34284267129184
Cellular Processes	Cell motility	hsa04814	Motor proteins	25/554	194/9376	2.18095202649894	TPM2/TUBA1B/TUBA1C/ACTB/TUBB4B/DYNLL1/ACTG1/MYO1B/TPM4/ACTA2/TUBB/MYL4/MYL9/TUBB6/TNNT1/MYO10/MYL6B/MYL3/TUBA1A/ACTR1B/CAPZB/MYO1C/KIFAP3/DYNLT3/KIF2A	4.16506199762855
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	28/554	235/9376	2.016498963054	NDUFA4/ACTB/GNAS/NDUFV3/ACTG1/COX5B/UQCRH/COX6C/COX5A/SMARCA2/GRB2/MT-CO3/COX7A1/NDUFC1/NDUFS8/COX7C/NDUFA3/COX8C/NDUFV2/CPT1C/AKT1S1/MAPK13/NDUFA6/CREB3/NDUFS5/CREB3L1/COX15/COX11	3.95458587171335
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/554	47/9376	3.60089100545357	LDHA/PKM/ADH5/LDHB/MDH2/ALDH1B1/DLD/ACACA/ALDH2/ACAT2	4.47930390748682
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	14/554	87/9376	2.72343250757293	TPM2/COX5B/UQCRH/TPM4/COX6C/COX5A/MYL4/MT-CO3/COX7A1/COX7C/MYL3/COX8C/SLC8A1/ATP1B3	4.04693677142608
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/554	50/9376	3.38483754512635	ODC1/P4HA2/SRM/ARG2/ALDH1B1/CKMT1A/LAP3/SMS/ALDH2/GOT1	4.23694757853063
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/554	110/9376	2.46170003281917	PGK1/LDHA/GAPDH/TIMP1/EGLN3/ENO1/ALDOA/EIF4EBP1/LDHB/ANGPT4/IGF1/MAP2K2/ALDOC/MKNK1/SLC2A1/LTBR	3.86425204296758
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	28/554	248/9376	1.91079538837778	GAPDH/TUBA1B/TUBA1C/ACTB/CASP4/ANXA2/TUBB4B/S100A10/DYNLL1/ACTG1/HSP90B1/ARPC3/RAC1/TUBB/CDC42/MYL9/TUBB6/ACTR3/MAP2K2/TUBA1A/ACTR1B/TXN2/MAPK13/VPS16/RAB9A/DYNLT3/PKN1/MYC	3.6426365548359
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/554	144/9376	2.23305254713197	PSMA7/PSMB2/PSMB6/PSMA4/PSMB3/PSMB1/VDAC2/PSMD8/PSMB5/PSMD11/SLC25A6/PSMD4/PSMA3/ADRM1/PSMD3/PSMD2/XBP1/PSMB4/PSMA1	3.73655970997628
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	24/554	204/9376	1.99108090889786	COL1A1/DCN/COL1A2/LUM/ACTB/MMP2/ACTG1/CD63/RAC1/CDC42/GRB2/CAV1/IGF1/PPP1CA/MAP2K2/THBS1/WNT2/MAPK13/WNT3A/TWIST1/ELK1/BRAF/HGF/MYC	3.58632104713697
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/554	106/9376	2.39493222532525	GSTP1/HSP90B1/GRB2/PTEN/IL1R2/MMP3/IGF1/ZEB1/ETV5/MAP2K2/CREB3/CREB3L1/CASP9/BRAF/PLAT	3.61928819878463
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	23/554	200/9376	1.94628158844765	GAPDH/TUBA1B/TUBA1C/ACTB/CASP4/TUBB4B/TMBIM6/TMED10/ACTG1/CLDN10/MYO1B/ARPC3/RAC1/TUBB/CDC42/TUBB6/MYO10/CLDN6/ACTR3/TUBA1A/MYO1C/MAPK13/CASP9	3.38973446804379
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/554	142/9376	2.14531957085473	MGST1/CYBA/GSTP1/CALM3/CALM1/ACTB/MMP2/ACTG1/HSP90B1/RAC1/CAV1/IL1R2/NCF1/TXN2/MAPK13/MEF2C/PLAT/RAC3	3.44613996857591
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/554	31/9376	3.82159077675556	TALDO1/TKT/ALDOA/GPI/PRPS2/ALDOC/RPE	3.94314016430313
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/554	89/9376	2.47207236441812	COL1A1/COL1A2/COL6A2/COL6A3/COL6A1/LAMA4/THBS1/TNXB/LAMB2/LAMA2/ITGA1/LAMC3/LAMB1	3.49657971756072
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/554	50/9376	3.04635379061372	HBA2/HBA1/GYPC/CD81/GYPA/GYPB/THBS1/HBB/HGF	3.6355909255439
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	33/554	333/9376	1.67717175659414	COL1A1/HLA-C/HLA-G/PKM/ISG15/COL1A2/COL6A2/GNAS/COL6A3/COL6A1/ATP6V1F/CDC42/EIF4EBP1/ATP6V1B1/GRB2/LAMA4/PTEN/CCND2/MAP2K2/THBS1/TNXB/RFNG/WNT2/LAMB2/WNT3A/CREB3/LAMA2/TCIRG1/ITGA1/LAMC3/CREB3L1/LAMB1/IRF9	3.15298337986534
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/554	51/9376	2.98662136334678	KDELR2/ACTB/GNAS/ACTG1/SEC61B/ATP6V1F/ATP6V1B1/PDIA4/TCIRG1	3.56478025006643
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	14/554	103/9376	2.3003750306684	COL1A1/COL3A1/COL1A2/COL6A2/COL6A3/COL6A1/COL14A1/COL5A2/COL18A1/SLC3A2/COL5A1/COL15A1/SLC8A1/ATP1B3	3.32532500490935
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/554	116/9376	2.18847255072825	CYBA/ACTB/MMP2/ACTG1/CLDN10/THY1/RAC1/JAM3/CDC42/MYL9/CLDN6/CXCL12/NCF1/MAPK13/ACTN1	3.2275252658698
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/554	54/9376	2.82069795427196	LDHA/CBS/PHGDH/LDHB/SRM/MDH2/SMS/CISD1/GOT1	3.36230594658293
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/554	107/9376	2.21437970241911	PYGL/LDHA/CALM3/PKM/CALM1/GNAS/LDHB/PGAM4/CPT1C/CREB3/SLC2A1/CREB3L1/PHKG2/ACACA	3.16582526926897
Genetic Information Processing	Translation	hsa03010	Ribosome	23/554	222/9376	1.75340683643933	RPL29/RPS4X/RPLP0/RPS3A/RPL13/RPL36/RPL36AL/RPL7A/MRPS15/RPS2/RPSA/RPL22L1/MRPL23/MRPL51/MRPL41/MRPL11/MRPL14/MRPL20/MRPL50/MRPS2/MRPL4/MRPL13/MRPS31	2.84680410707548
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/554	48/9376	2.82069795427196	HSD17B10/HMGCS1/ALDH1B1/HMGCL/DLD/ALDH2/ACAT2/PCCA	3.16899276785411
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/554	30/9376	3.38483754512635	IDH2/MDH2/ACO2/DLD/SUCLG2/IDH3A	3.2784120184012
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/554	59/9376	2.58165575475739	MGST1/GSTP1/PRDX6/ODC1/RRM2/SRM/IDH2/LAP3/SMS	3.05391480762096
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/554	70/9376	2.41774110366168	HLA-C/HLA-G/ACTB/ACTG1/RAC1/CD55/CAV1/LAMA2/CASP9/RAC3	2.98346825043466
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/554	31/9376	3.27564923721905	MDH2/ACO2/DLD/AFMID/ACAT2/PCCA	3.18019323746946
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/554	32/9376	3.17328519855596	LDHA/LDHB/DLD/SUCLG2/ACACA/PCCA	3.08590313971633
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/554	33/9376	3.07712504102396	GPT2/IDH2/ACO2/DLD/IDH3A/GOT1	2.99525244127649
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/554	103/9376	1.9717500262872	COL1A1/COL3A1/COL1A2/GNAS/LAMA4/ARG2/IL1R2/LAMB2/ACTN1/LAMA2/LAMC3/LAMB1	2.48496363335521
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/554	154/9376	1.7583571662994	PDXK/ALAS2/HMBS/NME1/ALDH1B1/UROD/RDH11/MPI/UMPS/DLD/MMAB/MTHFD1L/COX15/DHRS3/ALDH2/AFMID	2.37781789103818
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/554	71/9376	2.14531957085473	LDHA/PKM/LDHB/IDH2/PTEN/PGAM4/MAP2K2/SLC2A1/MYC	2.42747441551685
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	31/554	362/9376	1.44930889363145	COL1A1/COL1A2/COL6A2/HSP90B1/COL6A3/COL6A1/RAC1/EIF4EBP1/GNG11/ANGPT4/GRB2/LAMA4/PTEN/CCND2/IGF1/MAP2K2/THBS1/TNXB/EPHA2/LAMB2/CREB3/FGF7/LAMA2/ITGA1/LAMC3/CREB3L1/CASP9/HGF/LAMB1/PKN1/MYC	2.18472871744326
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	20/554	212/9376	1.59662148355017	CALM3/CALM1/ACTB/GNAS/ACTG1/RAC1/CDC42/ID1/ANGPT4/RALB/IGF1/MAP2K2/THBS1/EPHA2/MAPK13/FGF7/BRAF/PRKD3/HGF/RAC3	2.20181725949187
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	21/554	227/9376	1.5656737543536	HLA-C/HLA-G/CALR/CALM3/CALM1/PDIA3/GNAS/RAC1/EIF4EBP1/GNG11/GRB2/CCL4/CXCL12/MAP2K2/MAPK13/CREB3/CREB3L1/CASP9/ELK1/MYC/RAC3	2.16196738419323
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	10/554	85/9376	1.99108090889786	RRM2/GUK1/NME1/IMPDH1/ENPP1/NUDT16/ASMTL/IMPDH2/ADA/NTPCR	2.30008739051938
NA	NA	hsa04517	IgSF CAM signaling	26/554	299/9376	1.47166849788102	TUBA1B/TUBA1C/ACTB/TUBB4B/DYNLL1/ACTG1/ARPC3/RAC1/JAM3/TUBB/CDC42/MYL9/TUBB6/GRB2/MYL6B/ACTR3/MAP2K2/TUBA1A/MAPK13/APP/ACTN1/ERC1/NRP2/PMP22/CLMP/SPTAN1	2.07710423655184
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/554	75/9376	2.03090252707581	CGA/HSPA5/GNAS/HSP90B1/PDIA4/LRP2/ATP1B3/CREB3/CREB3L1	2.24615854453231
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/554	21/9376	3.22365480488224	DSEL/CHSY1/CHST12/CSGALNACT2	2.55630173357488
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/554	138/9376	1.71694658086119	PYGL/CALM3/CALM1/SOCS3/EIF4EBP1/GRB2/PPP1CA/MAP2K2/MKNK1/RHOQ/PHKG2/ELK1/ACACA/BRAF	2.12615222872014
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/554	139/9376	1.70459444718593	CALM3/CALM1/KRT18/GNAS/MMP2/HSP90B1/GRB2/KRT10/MAP2K2/KRT23/CREB3/CREB3L1/KRT24/FKBP4	2.09719173936329
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/554	89/9376	1.90159412647548	TUBA1B/TUBA1C/GNAS/TUBB4B/TUBB/TUBB6/GRB2/MAP2K2/TUBA1A/GJA1	2.14153584586322
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/554	43/9376	2.36151456636722	ADH5/ECI2/CPT1C/ALDH1B1/ALDH2/ACAT2	2.24234731429728
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/554	44/9376	2.30784378076797	OSTC/DAD1/KRTCAP2/DDOST/B4GALT2/TUSC3	2.17897294815551
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/554	44/9376	2.30784378076797	GNAS/DYNLL1/RAB11A/AQP2/CREB3/CREB3L1	2.17897294815551
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/554	170/9376	1.59286472711828	TUBA1B/TUBA1C/ACTB/ACTG1/CLDN10/ARPC3/RAC1/JAM3/CDC42/MYL9/CLDN6/MYL6B/ACTR3/RAB13/TUBA1A/ACTN1	1.9547966303544
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/554	105/9376	1.77301014268523	TPM2/ACTB/GNAS/ACTG1/TPM4/MYL3/IGF1/SLC8A1/LAMA2/ITGA1/EMD	1.99605978621041
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/554	56/9376	2.11552346570397	BNIP3/HSPD1/VCP/SAR1A/HSF1/C3/CASP9	2.09807863603379
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/554	93/9376	1.81980513178836	ACTB/ACTG1/RAC1/CDC42/MYL9/ACP1/CCM2/ACTN1/RASIP1/RAC3	1.9909709597424
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/554	93/9376	1.81980513178836	CGA/CALM3/CALM1/GNAS/MMP2/CDC42/GRB2/MAP2K2/MAPK13/ELK1	1.9909709597424
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/554	34/9376	2.48885113612232	POLR1D/POLR1C/POLR2F/POLR3H/POLR2I	2.17935408845932
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/554	46/9376	2.20750274682154	ALAS2/HMBS/UROD/MMAB/FXN/COX15	2.05723173504024
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	13/554	134/9376	1.64189880920308	CALM3/CALM1/GNAS/PLA2G2A/ACTA2/MYL9/PPP1R14A/MYL6B/PPP1CA/MAP2K2/RAMP2/BRAF/RAMP1	1.87539598090681
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/554	70/9376	1.93419288292935	EGLN3/RAC1/CDC42/GRB2/MAP2K2/SLC2A1/BRAF/HGF	1.96589828622675
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/554	83/9376	1.83515288591188	IDH2/SLC27A2/ECI2/MPV17L2/HMGCL/CROT/PEX1/PEX10/PEX16	1.91506737463189
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/554	59/9376	2.00795447592241	GRB2/PTEN/MAP2K2/CASP9/ELK1/BRAF/MYC	1.9461928363163
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	18/554	205/9376	1.48602623932377	HLA-C/HLA-G/CALR/ISG15/PDIA3/RAC1/PSMD8/PSMD11/PSMD4/CCND2/ADRM1/PSMD3/PSMD2/MAPK13/SAP30/CASP9/IRF9/MYC	1.76313389289903
NA	NA	hsa03272	Virion - Hepatitis viruses	6/554	48/9376	2.11552346570397	CD81/CLDN10/CD63/EPCAM/CLDN6/CD9	1.94161024177182
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/554	99/9376	1.70951391167998	TPM2/ACTB/ACTG1/TPM4/MYL3/IGF1/SLC8A1/LAMA2/ITGA1/EMD	1.7784093298359
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	19/554	224/9376	1.43553378029912	HLA-C/HLA-G/CALR/RAN/RANBP1/VDAC2/PTEN/IL1R2/SLC25A6/CCND2/MAP2K2/CREB3/SLC2A1/CHEK2/MSX2/CREB3L1/ELK1/MYC/LTBR	1.65327402356815
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/554	75/9376	1.80524669073406	RRM2/SHISA5/PTEN/CCND2/IGF1/THBS1/CHEK2/CASP9	1.75449345340062
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/554	88/9376	1.73088283557598	TFPI/PROCR/C1R/CFD/C1S/CD55/C3/SERPINB2/PLAT	1.72617566330458
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/554	128/9376	1.58664259927798	RRM2/GUK1/PAICS/PRPS2/PDE4D/NME1/IMPDH1/ENPP1/NUDT16/IMPDH2/ADA/NTPCR	1.67460222681505
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/554	157/9376	1.50916323668054	HLA-C/HLA-G/CALM3/CALM1/EIF4EBP1/VDAC2/PTEN/SLC25A6/CCND2/PPP1CA/MAP2K2/MAPK13/CHEK2/MYC	1.61221126411077
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/554	130/9376	1.56223271313524	COL1A1/COL3A1/COL1A2/GNAS/MMP2/ACTA2/GNG11/GRB2/MAP2K2/MAPK13/CREB3/CREB3L1	1.61758770247878
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/554	41/9376	2.06392533239412	CBS/PHGDH/ALAS2/PGAM4/DLD	1.71081445390848
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/554	41/9376	2.06392533239412	MMP2/MAP2K2/THBS1/BRAF/MYC	1.71081445390848
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/554	93/9376	1.63782461860953	LAMA4/PTEN/LAMB2/LAMA2/ZBTB17/LAMC3/CASP9/LAMB1/MYC	1.54901481317901
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/554	42/9376	2.0147842530514	ALDH1B1/DLD/ALDH2/AFMID/ACAT2	1.65166307687778
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/554	108/9376	1.56705441903998	RAN/RBM8A/THOC5/EIF4A3/KPNA2/ALYREF/THOC3/THOC7/THOC1/AAAS	1.48525354719071
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	19/554	238/9376	1.35109061675212	RPL29/RPS4X/RPLP0/RPS3A/ISG15/RPL13/RPL36/RPL36AL/RPL7A/C1R/RPS2/RPSA/CFD/RPL22L1/C1S/MMP3/MAPK13/C3/IRF9	1.37479871702391
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/554	56/9376	1.81330582774626	OSTC/DAD1/KRTCAP2/DDOST/B4GALT2/TUSC3	1.5296671331601
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/554	180/9376	1.41034897713598	HLA-C/HLA-G/CALR/PDIA3/SOCS3/EIF4EBP1/SRSF9/PILRA/PPP1CA/EIF2B3/ALYREF/C3/CASP9/IRF9/EIF2B4	1.39298718250107
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/554	154/9376	1.42866519761827	CALM3/TPM2/CALM1/GNAS/TPM4/MYL4/MYL3/PPP1CA/SLC8A1/ATP1B3/MAPK13/CREB3/CREB3L1	1.34407350712594
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/554	21/9376	2.41774110366168	ALDH1B1/ENPP1/ALDH2	1.62982763021198
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/554	71/9376	1.66858188844257	ATP6V1F/RAC1/JAM3/CDC42/ATP6V1B1/MAPK13/TCIRG1	1.41704155780826
Genetic Information Processing	Transcription	hsa03040	Spliceosome	19/554	243/9376	1.32329039830043	SNRPD2/U2AF1/RBM8A/SRSF9/SNRPF/SNRPG/LSM5/SNRPD3/THOC5/XAB2/EIF4A3/DHX16/LSM2/ALYREF/RP9/THOC3/TXNL4A/THOC7/THOC1	1.27951743514319
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/554	99/9376	1.53856252051198	KRT18/C1R/CFD/C1S/KRT10/KRT23/DEFB1/C3/KRT24	1.34991660545543
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	14/554	170/9376	1.3937566362285	MGST1/GSTP1/ACTB/ACTG1/SMARCA2/GRB2/PTEN/MAP2K2/WNT2/WNT3A/ELK1/BRAF/HGF/MYC	1.29829640805328
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/554	87/9376	1.55624714718453	RAC1/GRB2/RALB/MAP2K2/CASP9/BRAF/MYC/RAC3	1.30617069368855
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/554	158/9376	1.39249645843806	ATP6V1F/EIF4EBP1/ATP6V1B1/GRB2/SLC3A2/PTEN/IGF1/MAP2K2/WNT2/AKT1S1/WNT3A/BRAF/CAB39L	1.24681761059409
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/554	60/9376	1.69241877256318	RAC1/CDC42/MAP2K2/MAPK13/CASP9/RAC3	1.34830055371126
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/554	35/9376	1.93419288292935	TPI1/ALDOA/ALDOC/MPI	1.38749326693467
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/554	23/9376	2.20750274682154	GPT2/ARG2/GOT1	1.45289280155954
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/554	23/9376	2.20750274682154	HMGCS1/DHDDS/ACAT2	1.45289280155954
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	16/554	205/9376	1.32091221273224	HLA-C/HLA-G/PKM/RAC1/RANBP1/CDC42/GRB2/CCND2/DDX3X/ACTN1/CREB3/C3/HDAC3/CREB3L1/IRF9/LTBR	1.16415772058042
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/554	36/9376	1.88046530284797	PYGL/GYG2/GPI/ENPP1	1.3263161326074
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/554	76/9376	1.55880676420293	CALM3/CALM1/ACTB/GNAS/ACTG1/GAST/ATP1B3	1.22569939066574
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/554	76/9376	1.55880676420293	CALM3/CALM1/GRB2/PTEN/IGF1/MAP2K2/BRAF	1.22569939066574
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/554	77/9376	1.53856252051198	RALBP1/RAC1/CDC42/RALB/CASP9/BRAF/RAC3	1.18910542206012
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/554	37/9376	1.82964191628452	GPT2/NIT2/RIMKLB/GOT1	1.26706342310062
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/554	37/9376	1.82964191628452	ADH5/MIF/COMT/GOT1	1.26706342310062
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/554	37/9376	1.82964191628452	HBA2/HBA1/LAMA4/HBB	1.26706342310062
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/554	78/9376	1.51883735999259	TPI1/IMPA2/ITPKB/PTEN/INPP5K/MTMR4/IPPK	1.15303041951877
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/554	78/9376	1.51883735999259	ENO1/HSPD1/BTG1/LSM5/LSM2/NUDT16/PABPC4	1.15303041951877
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/554	78/9376	1.51883735999259	ACTB/ACTG1/ARPC3/RAC1/CDC42/CAV1/ACTR3	1.15303041951877
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/554	122/9376	1.38722850210096	LEP/EIF4EBP1/IGF1/SCD/CPT1C/AKT1S1/CREB3/CREB3L1/ACACA/CAB39L	1.07879637342497
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/554	122/9376	1.38722850210096	ACTB/ACTG1/DIO3/MAP2K2/ATP1B3/MED27/SLC2A1/HDAC3/CASP9/MYC	1.07879637342497
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/554	52/9376	1.62732574284921	CGA/GNAS/CYP11A1/IGF1/ACOT4	1.13671251829822
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/554	80/9376	1.48086642599278	EIF4EBP1/GRB2/PTEN/IGF1/MAP2K2/BRAF/HGF	1.08237657743794
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/554	109/9376	1.39740999569437	PYGL/SOCS3/PTEN/SLC27A2/PPP1CA/SLC27A4/CREB3/SLC2A1/CREB3L1	1.04577787064362
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/554	14/9376	2.41774110366168	CHST2/B4GALT2	1.33025109182492
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/554	154/9376	1.31876787472455	CALM3/CALM1/ACTB/GNAS/ACTG1/MYL9/MYL6B/PPP1CA/MAP2K2/TRPM2/MEF2C/ELK1	0.999492045821858
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/554	53/9376	1.59662148355017	GNAS/RAB11A/AP2A1/SLC8A1/ATP1B3	1.0914804825216
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/554	82/9376	1.44474773267588	MGST1/GSTP1/RRM2/NME1/IMPDH1/UMPS/IMPDH2	1.01362270167278
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/554	82/9376	1.44474773267588	HLA-C/HLA-G/CALR/HSPA5/PDIA3/HSPA2/PSME3	1.01362270167278
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/554	27/9376	1.88046530284797	HMGCS1/HMGCL/ACAT2	1.14807045860186
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/554	15/9376	2.25655836341757	ACP1/NTPCR	1.22046173010876
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/554	98/9376	1.38156634494953	CALM3/CALM1/GNAS/CYP11A1/ATP1B3/CREB3/CREB3L1/PRKD3	0.951509019798235
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/554	69/9376	1.47166849788102	CALM3/CALM1/GNAS/PPP1CA/CREB3/CREB3L1	0.985402258925049
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/554	28/9376	1.81330582774626	ATP6V1F/ATP6V1B1/TCIRG1	1.08001687653909
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/554	71/9376	1.43021304723649	CGA/SOCS3/GRB2/CCND2/MAP2K2/MAPK13	0.911825128953966
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/554	238/9376	1.20887055183084	RALBP1/CALM3/CALM1/PLA2G2A/RAC1/CDC42/GNG11/ANGPT4/GRB2/RALB/IGF1/MAP2K2/EPHA2/FGF7/ELK1/HGF/RAC3	0.817894164582182
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/554	16/9376	2.11552346570397	MIF/GOT1	1.11907133429962
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/554	86/9376	1.37755016371421	ACTB/ACTG1/SLC8A1/GJA1/LAMA2/ITGA1/EMD	0.881399957822697
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/554	101/9376	1.34052972084212	CALM3/CALM1/GNAS/MAP2K2/WNT2/WNT3A/CREB3/CREB3L1	0.86221533737301
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/554	43/9376	1.57434304424482	PLA2G2A/SLC27A4/AGPAT2/ACAT2	0.945914656046601
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/554	44/9376	1.53856252051198	TAF10/TAF13/GTF2F1/MNAT1	0.897288483795031
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/554	73/9376	1.39102912813412	PTEN/IGF1/MAP2K2/FGF7/BRAF/HGF	0.840458014727716
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/554	59/9376	1.43425319708744	RRM2/NME1/UMPS/ENPP1/ASMTL	0.838470865011642
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/554	166/9376	1.22343525727459	CALM3/CALM1/MYL9/VDAC2/SLC25A6/PPP1CA/MAP2K2/SLC8A1/ATP1B3/CREB3/MEF2C/CREB3L1	0.727834984950666
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/554	76/9376	1.33612008360251	PLTP/SLC27A2/SCD/CPT1C/HMGCS1/SLC27A4	0.73725339071326
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/554	138/9376	1.22639041490085	ACTB/ACTG1/ARPC3/RAC1/CDC42/ACTR3/MAP2K2/MAPK13/PKN1/RAC3	0.671375661801944
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/554	33/9376	1.53856252051198	STX8/BET1L/USE1	0.776617041576034
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/554	19/9376	1.78149344480334	IDUA/HYAL3	0.854458194361445
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/554	78/9376	1.30186059427937	CALM3/CALM1/C1R/C1S/MAPK13/C3	0.670835360936788
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/554	140/9376	1.20887055183084	CALM3/CALM1/ACTA2/MYL4/GNG11/MYL3/MAP2K2/SLC8A1/MEF2C/PLAT	0.623959302178077
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/554	63/9376	1.34318950203427	ALDH1B1/SETD7/DLD/ALDH2/ACAT2	0.684883118696489
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/554	156/9376	1.19337221142275	CD81/CLDN10/SOCS3/GRB2/CLDN6/MAP2K2/PSME3/CASP9/BRAF/IRF9/MYC	0.610306360873438
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/554	157/9376	1.18577111453471	CALR/ODC1/RAC1/SLC16A1/ARG2/MAP2K2/THBS1/CPT1C/MAPK13/VPS16/SLC2A1	0.588224486417872
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/554	110/9376	1.23085001640958	DCN/ID3/ID1/LRRC32/THBS1/NBL1/GREM2/MYC	0.610291186632403
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/554	144/9376	1.17529081427998	ID3/ID1/GRB2/IGF1/LIFR/MAP2K2/WNT2/MAPK13/WNT3A/MYC	0.531189522856095
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/554	226/9376	1.12328679594901	CGA/CALM3/CALM1/GNAS/RAC1/MYL9/PPP1CA/MAP2K2/PDE4D/HCAR3/ATP1B3/CREB3/CREB3L1/BRAF/RAC3	0.470129206599271
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/554	98/9376	1.20887055183084	CALM3/CALM1/IMPA2/ITPKB/PTEN/MTMR4/IPPK	0.520858866794361
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/554	178/9376	1.14095647588529	DKK1/RAC1/APCDD1/FRZB/CCND2/WNT2/WNT3A/RSPO3/RUVBL1/MYC/RAC3/TLE2	0.47577906181084
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/554	67/9376	1.26299908400237	CALM3/CALM1/PPP1CA/MAP2K2/BRAF	0.541373652710912
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/554	99/9376	1.19665973817598	GNAS/MMP2/GRB2/IGF1/MAP2K2/MAPK13/BRAF	0.492931156694506
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/554	52/9376	1.30186059427937	VDAC2/PLTP/LRPAP1/LRP2	0.546970565467096
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/554	115/9376	1.17733479830482	NACA/GNAS/MMP15/PDE4D/CREB3/MEF2C/CREB3L1/BRAF	0.479480486420675
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/554	68/9376	1.24442556806116	EIF4EBP1/GRB2/MAP2K2/BRAF/MYC	0.506908876312185
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/554	37/9376	1.37223143721339	GPI/GNPNAT1/MPI	0.568487234991045
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/554	37/9376	1.37223143721339	MAP2K2/BRAF/MYC	0.568487234991045
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/554	22/9376	1.53856252051198	ALDH1B1/ALDH2	0.633732205930038
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/554	149/9376	1.13585152521019	NDUFA4/NDUFV3/GNG11/NDUFC1/NDUFS8/NDUFA3/NDUFV2/MAPK13/NDUFA6/NDUFS5	0.418874947456111
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/554	69/9376	1.22639041490085	RAC1/GRB2/MAP2K2/MAPK13/RAC3	0.472971222891701
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/554	69/9376	1.22639041490085	CALM3/CALM1/GNAS/REN/AQP1	0.472971222891701
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/554	133/9376	1.14524578594501	BNIP3/GRB2/PTEN/CCND2/IGF1/MAP2K2/SETD7/MAPK13/BRAF	0.422746361848032
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/554	133/9376	1.14524578594501	CALM3/CALM1/GNAS/GNG11/PPP1CA/COMT/MAPK13/CREB3/CREB3L1	0.422746361848032
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/554	101/9376	1.17296350573686	COL1A1/COL3A1/COL1A2/MMP2/RAC1/CDC42/MAPK13	0.437940591744305
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/554	38/9376	1.33612008360251	GPI/GNPNAT1/MPI	0.520255068858243
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/554	232/9376	1.09423627536412	ACTB/ACTG1/ARPC3/RAC1/CDC42/MYL9/CXCL12/ACTR3/PPP1CA/MAP2K2/ACTN1/FGF7/ITGA1/BRAF/RAC3	0.364209265551093
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/554	23/9376	1.47166849788102	ATP1B3/AQP1	0.567521495994595
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/554	86/9376	1.18075728318361	EIF4EBP1/GRB2/MAP2K2/ELK1/BRAF/MYC	0.421982234643599
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	14/554	216/9376	1.09693809332799	CYBA/CALM3/HSPA5/CALM1/HSPA2/HSP90B1/HSPD1/RAC1/CDC42/MMP3/NCF1/XBP1/MAPK13/CASP9	0.361185748618934
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/554	39/9376	1.30186059427937	CBS/DLD/MTHFD1L	0.473360527971553
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/554	103/9376	1.1501875153342	RBM8A/PPP1CA/EIF4A3/ALYREF/FIP1L1/CPSF4/PABPC4	0.384060204469868
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/554	201/9376	1.09459920613539	IL1R2/MMP3/MAF/CCND2/IGF1/ZEB1/ETV5/HOXA10/MEF2C/ZBTB17/MYC/PLAT/ETV4	0.339734364119118
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	8/554	120/9376	1.12827918170878	CALM3/CALM1/RAC1/CDC42/GRB2/MAP2K2/MAPK13/BRAF	0.354398703799354
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/554	187/9376	1.0860441321261	CYBA/CASP4/SUGT1/VDAC2/TXN2/MAPK13/TRPM2/BRCC3/SHARPIN/TP53BP1/IRF9/PKN1	0.2978275917853
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/554	122/9376	1.10978280168077	GNAS/SOCS3/GRB2/IGF1/MAP2K2/MAPK13/CREB3/CREB3L1	0.305848582103518
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/554	73/9376	1.15919094011176	GRB2/MAP2K2/CASP9/BRAF/HGF	0.342156867257938
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/554	57/9376	1.18766229653556	SCD/CPT1C/ACACA/ACAT2	0.35611215095715
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/554	173/9376	1.07610442186098	ACTB/ACTG1/RAB11A/SOCS3/DNAJC3/SLC25A6/MAP2K2/KPNA2/CASP9/CPSF4/IRF9	0.253177569024651
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/554	157/9376	1.0779737404861	ACTB/ACTG1/ID1/CCND2/PPP1CA/YAP1/WNT2/WNT3A/MYC/LATS2	0.246895560520238
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/554	91/9376	1.11588050938231	CD81/IFITM1/RAC1/GRB2/MAP2K2/RAC3	0.278353785268892
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/554	10/9376	1.69241877256318	SELENBP1	0.548970175737521
Organismal Systems	Immune system	hsa04611	Platelet activation	8/554	126/9376	1.07455160162741	COL1A1/COL3A1/COL1A2/ACTB/GNAS/ACTG1/PPP1CA/MAPK13	0.21111951429867
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/554	60/9376	1.12827918170878	GNAS/IGF1/MAP2K2/BRAF	0.249789431744213
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/554	27/9376	1.25364353523198	SCD/ACOT4	0.330734952159107
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/554	195/9376	1.04148847542349	CYBA/ACTB/CASP4/ACTG1/RAC1/VDAC2/SLC25A6/MAP2K2/NCF1/MAPK13/C3/HDAC3	0.146709008471291
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/554	44/9376	1.15392189038398	HLA-C/HLA-G/HSPD1	0.256446251614789
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/554	78/9376	1.08488382856614	CYBA/NCF1/MAPK13/C3/ELK1	0.18864030235481
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/554	196/9376	1.03617475871215	HLA-C/HLA-G/CALM3/CALM1/RAC1/GNG11/MAP2K2/MAPK13/C3/CASP9/IRF9/MYC	0.128253531373419
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/554	112/9376	1.05776173285199	LAMA4/LAMB2/MAPK13/LAMA2/LAMC3/CASP9/LAMB1	0.154101528203435
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/554	163/9376	1.03829372549888	GRB2/DDX3X/MAP2K2/MAPK13/CREB3/CREB3L1/CASP9/ELK1/BRAF/MYC	0.123588448507732
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/554	45/9376	1.12827918170878	ABCG2/ABCA7/DEFB1	0.216150048303791
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/554	62/9376	1.09188307907302	RFNG/DTX2/NUMBL/TLE2	0.18189479097579
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/554	79/9376	1.07115112187543	ATP6V1F/ATP6V1B1/SLC1A2/AP2A1/TCIRG1	0.15914055789465
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	18/554	300/9376	1.01545126353791	RAC1/CDC42/ANGPT4/GRB2/IGF1/MAP2K2/EPHA2/RPS6KA4/ECSIT/MAPK13/FGF7/MEF2C/MKNK1/ELK1/BRAF/HGF/MYC/RAC3	0.0681607526750093
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/554	148/9376	1.02917357791004	GRB2/PTEN/IGF1/MAP2K2/WNT2/WNT3A/FGF7/BRAF/MYC	0.0896445215829091
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/554	29/9376	1.1671853603884	YAP1/LATS2	0.225953002745585
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/554	29/9376	1.1671853603884	CALM3/CALM1	0.225953002745585
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/554	98/9376	1.03617475871215	ARPC3/RAC1/CDC42/MYO10/ACTR3/NCF1	0.0902087137904873
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/554	253/9376	1.00341033946433	BNIP3/ACTB/CASP4/ACTG1/ARPC3/RAC1/U2AF1/CDC42/MYL9/ACTR3/AKT1S1/MAPK13/ACTN1/C3/SHARPIN	0.0137798987871646
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/554	99/9376	1.02570834700799	CALM3/CALM1/GNAS/IGF1/PPP1CA/MAPK13	0.0644384323140418
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/554	99/9376	1.02570834700799	RAC1/EIF4EBP1/GRB2/MAP2K2/PCYT1A/RAC3	0.0644384323140418
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/554	65/9376	1.04148847542349	ALDH1B1/AGPAT4/AGPAT2/ALDH2	0.0841090998193666
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/554	65/9376	1.04148847542349	GNAS/CYP11A1/CREB3/CREB3L1	0.0841090998193666
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/554	117/9376	1.01255823999506	ACTB/ACTG1/SMARCA2/ACTR8/RUVBL1/MCRS1/UCHL5	0.0342528459290432
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/554	13/9376	1.30186059427937	XRCC6	0.27291510992577
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/554	83/9376	1.01952938106215	CCL4/POLR1D/POLR1C/POLR2F/POLR3H	0.04478231608821
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/554	31/9376	1.09188307907302	ALDH1B1/ALDH2	0.128405530134763
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/554	31/9376	1.09188307907302	ALDH1B1/ALDH2	0.128405530134763
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/554	49/9376	1.03617475871215	GALNT2/RFNG/B4GALT2	0.0636194175176739
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/554	49/9376	1.03617475871215	GNAS/CREB3/CREB3L1	0.0636194175176739
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/554	137/9376	0.988273735803315	TUBA1B/TUBA1C/ACTB/ACTG1/MAP2K2/TUBA1A/CASP9/SPTAN1	-0.0346469068645214
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/554	32/9376	1.05776173285199	CASP9/BOK	0.0820173591951185
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/554	68/9376	0.995540454448928	ADH5/ALDH1A3/RDH11/DHRS3	-0.00924855465035269
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/554	86/9376	0.98396440265301	GNAS/ATP1B3/CREB3/SLC2A1/CREB3L1	-0.0374354885354979
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/554	104/9376	0.976395445709525	PLA2G2A/PHOSPHO1/AGPAT4/AGPAT2/PCYT1A/PISD	-0.0606572555055159
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/554	105/9376	0.967096441464673	BNIP3/TOMM20/FKBP8/TAX1BP1/VCP/PHB2	-0.0849632707113534
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/554	193/9376	0.964591010269168	CXCL14/RAC1/CDC42/GNG11/GRB2/CCR7/CCL4/CXCL12/NCF1/BRAF/RAC3	-0.124553774233215
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/554	70/9376	0.967096441464673	LEP/SOCS3/CPT1C/SLC2A1	-0.0692416421890622
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/554	34/9376	0.995540454448928	RORB/NFIL3	-0.00652780428721237
NA	NA	hsa04519	Cadherin signaling	23/554	404/9376	0.963505736855274	ACTB/KRT18/ACTG1/MYO1B/ARPC3/RAC1/CDC42/CDH11/KRT10/ACTR3/PPP1CA/MAP2K2/YAP1/KRT23/WNT2/MYO1C/MAPK13/ACTN1/WNT3A/GJA1/KRT24/LATS2/RAC3	-0.187900373417764
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	12/554	214/9376	0.949019872465333	HLA-C/HLA-G/CALR/CALM3/CALM1/PDIA3/RAC1/GNG11/MAP2K2/MAPK13/CASP9/RAC3	-0.189046941009871
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/554	90/9376	0.940232651423987	EIF4EBP1/IGF1/AKT1S1/CREB3/CREB3L1	-0.142767021411797
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/554	90/9376	0.940232651423987	GNAS/ABCG2/ATP1B3/AQP1/SLC2A1	-0.142767021411797
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/554	250/9376	0.947754512635379	HLA-C/HLA-G/RAB11A/ARPC3/CDC42/CAV1/AP2A1/ACTR3/DAB2/CAPZB/SNX6/SNF8/ARF5/VPS26B	-0.209814525286929
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/554	144/9376	0.940232651423987	ADH5/SCD/CPT1C/ALDH1B1/MAPK13/C3/ACACA/ALDH2	-0.181114963170614
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/554	54/9376	0.940232651423987	HLA-C/HLA-G/CGA	-0.110373118757624
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/554	73/9376	0.927352752089412	RAN/MAP1B/NELFB/MAP1S	-0.156144280211839
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/554	36/9376	0.940232651423987	SSBP1/RNASEH2C	-0.090032393511846
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/554	55/9376	0.923137512307187	GALC/CERK/SMPD2	-0.143258869972428
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/554	17/9376	0.995540454448928	NRP2	-0.00461166057604813
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/554	184/9376	0.91979281117564	RAC1/CDC42/MYL9/SEMA6A/CXCL12/FES/EPHA2/EPHB4/SEMA5A/RAC3	-0.275343096748568
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/554	38/9376	0.890746722401672	NNMT/ENPP1	-0.169104954546913
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/554	38/9376	0.890746722401672	IGF1/ATP1B3	-0.169104954546913
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/554	18/9376	0.940232651423987	ACACA	-0.063601259467591
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/554	18/9376	0.940232651423987	MMAB	-0.063601259467591
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/554	150/9376	0.902623345367028	GRB2/MAP2K2/WNT2/WNT3A/FGF7/BRAF/HGF/MYC	-0.301266435163481
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/554	95/9376	0.890746722401672	ATP6V1F/ATP6V1B1/CXCL12/MMP3/TCIRG1	-0.268198216084685
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/554	77/9376	0.879178583149702	GRB2/MAP2K2/BRAF/MYC	-0.266764574967261
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/554	133/9376	0.890746722401672	HLA-C/HLA-G/RAC1/GRB2/MAP2K2/BRAF/RAC3	-0.31798805951006
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/554	39/9376	0.867907062852911	HLA-C/HLA-G	-0.207140592890342
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/554	19/9376	0.890746722401672	DLD	-0.119453795710632
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/554	79/9376	0.856920897500343	MGST1/GSTP1/ADH5/CBR1	-0.320018681289756
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/554	191/9376	0.886083126996428	CALM3/CALM1/GNAS/GNG11/GRB2/PPP1CA/CREB3/HDAC3/CREB3L1/BRAF	-0.398586102699206
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/554	155/9376	0.873506463258414	GNAS/CYP11A1/MAP2K2/WNT2/WNT3A/CREB3/CREB3L1/BRAF	-0.397925863595693
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/554	20/9376	0.846209386281588	NSDHL	-0.172526858785551
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/554	41/9376	0.825570132957647	SSBP1/BRCC3	-0.280486918248174
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/554	61/9376	0.832337101260579	SLC39A4/SLC8A1/ATP1B3	-0.329205780367679
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/554	100/9376	0.846209386281588	CXCL14/CCR7/CCL4/CXCL12/LTBR	-0.387441782321856
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/554	100/9376	0.846209386281588	GYPA/CD55/IL1R2/CD9/ITGA1	-0.387441782321856
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/554	119/9376	0.853320389527652	SOCS3/MMP3/RPS6KA4/MAPK13/CREB3/CREB3L1	-0.403520023919364
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/554	62/9376	0.818912309304763	IGF1/CRYAB/AKT1S1	-0.358487198944681
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/554	42/9376	0.80591370122056	VDAC2/SLC3A2	-0.315894903234797
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	13/554	250/9376	0.880057761732852	LAPTM4B/CD63/ATP6V1F/ATP6V1B1/AP2A1/AKT1S1/IDUA/VPS16/TCIRG1/GALC/VPS26B/DMXL1/HYAL3	-0.481680333618915
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/554	63/9376	0.80591370122056	PTGDS/PLA2G2A/CBR1	-0.38732661930623
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/554	63/9376	0.80591370122056	POLR2F/POLR2I/MNAT1	-0.38732661930623
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/554	102/9376	0.829617045374106	GNAS/PLA2G2A/RAB11A/RAC1/ATP1B3	-0.433560470643914
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/554	142/9376	0.834290944221284	CYBA/SOCS3/RAC1/GRB2/NCF1/MAPK13/IRF9	-0.49860022897176
NA	NA	hsa04382	Cornified envelope formation	11/554	217/9376	0.857908133557371	KRT18/S100A6/S100A10/CLDN10/CLDN6/KRT10/S100A16/KRT23/SLC27A4/PADI1/KRT24	-0.530679180992111
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/554	217/9376	0.857908133557371	MGST1/GNAS/HSP90B1/EIF4EBP1/GRB2/MAP2K2/KPNA2/CREB3/FGF7/CREB3L1/MYC	-0.530679180992111
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/554	143/9376	0.828456741814143	C1R/SSB/C1S/SNRPD3/ACTN1/C3/TRIM21	-0.517997005743219
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/554	45/9376	0.75218612113919	HLA-C/HLA-G	-0.417565665547473
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/554	23/9376	0.735834248940512	B4GALT2	-0.31784980957035
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/554	23/9376	0.735834248940512	SSBP1	-0.31784980957035
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/554	23/9376	0.735834248940512	REN	-0.31784980957035
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/554	125/9376	0.812361010830325	RAC1/PTEN/MAP2K2/MAPK13/RAC3/SMPD2	-0.529225478872306
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/554	24/9376	0.70517448856799	EXTL2	-0.362389350148636
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/554	47/9376	0.720178201090714	PKM/SOCS3	-0.481914418799636
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/554	109/9376	0.77633888649687	RAC1/CCL4/MAP2K2/MAPK13/IRF9	-0.588560543416651
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	8/554	169/9376	0.801144981094995	BNIP3/TAX1BP1/PTEN/MAP2K2/AKT1S1/MTMR4/VPS16/WDR41	-0.653699015951909
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/554	70/9376	0.725322331098504	MGST1/GSTP1/CBR1	-0.578026624293016
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/554	26/9376	0.650930297139683	PLA2G2A	-0.446632188000313
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/554	50/9376	0.676967509025271	CXCL12/LTBR	-0.573905645363186
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/554	72/9376	0.70517448856799	ISG15/DDX3X/MAPK13	-0.629293798283974
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/554	93/9376	0.727922052715345	CALM3/CALM1/GNAS/ATP1B3	-0.660765919637981
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/554	73/9376	0.695514564067059	MGST1/GSTP1/ADH5	-0.654445427681617
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/554	28/9376	0.60443527591542	ACOT4	-0.525284048386481
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/554	28/9376	0.60443527591542	B4GALT2	-0.525284048386481
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/554	28/9376	0.60443527591542	CBR1	-0.525284048386481
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/554	75/9376	0.676967509025271	MGST1/GSTP1/CASP9	-0.703832002257848
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/554	97/9376	0.697904648479661	CALM3/CALM1/GNAS/GNG11	-0.749439046052596
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/554	30/9376	0.564139590854392	PIGK	-0.59917288982991
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/554	30/9376	0.564139590854392	PLA2G2A	-0.59917288982991
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/554	30/9376	0.564139590854392	ABCG2	-0.59917288982991
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/554	160/9376	0.74043321299639	HLA-C/HLA-G/CLDN10/VCAN/JAM3/CLDN6/SDC3	-0.82984097174969
NA	NA	hsa04981	Folate transport and metabolism	1/554	31/9376	0.545941539536509	ABCG2	-0.63454139669891
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/554	56/9376	0.60443527591542	CCND2/LRP2	-0.743978878334682
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/554	32/9376	0.528880866425993	B4GALT2	-0.668954085935185
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/554	103/9376	0.657250008762399	CALR/GNAS/MAPK13/C3	-0.876481852861339
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/554	59/9376	0.573701278834975	CGA/GNAS	-0.823112091945345
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/554	168/9376	0.70517448856799	LEP/SOCS3/GRB2/CCND2/LIFR/IRF9/MYC	-0.966260085510271
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/554	105/9376	0.644730960976448	CCL4/CXCL12/ERC1/LTBR	-0.917372493480058
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/554	105/9376	0.644730960976448	CALM3/CALM1/MAPK13/IRF9	-0.917372493480058
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/554	149/9376	0.681510915126111	GNAS/GRB2/RALB/MAP2K2/AGPAT4/AGPAT2	-0.982006631765755
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/554	36/9376	0.470116325711994	RPE	-0.798206656571467
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/554	36/9376	0.470116325711994	GALNT2	-0.798206656571467
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/554	254/9376	0.732937263708462	CALM3/CALM1/GNAS/VDAC2/ITPKB/TACR3/SLC25A6/SLC8A1/FGF7/PHKG2/HGF	-1.08128981589553
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/554	63/9376	0.537275800813707	WNT2/WNT3A	-0.923431488307589
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/554	110/9376	0.615425008204792	IGF1/MAPK13/STK10/BRAF	-1.01668924153519
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/554	38/9376	0.445373361200836	ADA	-0.858464977952069
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/554	65/9376	0.520744237711747	CGA/MAP2K2	-0.971589588140983
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/554	90/9376	0.564139590854392	PTEN/MAP2K2/MAPK13	-1.04114527158429
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/554	66/9376	0.512854173503993	CYP11A1/COMT	-0.995206278739858
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/554	136/9376	0.62221278403058	CCND2/EIF3H/RAB9A/CASP9/IRF9	-1.1120843268295
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/554	91/9376	0.557940254691157	GNAS/GNG11/PDE4D	-1.06186108498845
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/554	115/9376	0.588667399152409	GNAS/GNG11/APP/BRAF	-1.11216725324307
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/554	181/9376	0.654526597123881	CALM3/CALM1/HSPD1/MAPK13/TCIRG1/C3/CASP9	-1.17607503803221
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/554	138/9376	0.613195207450426	CALM3/CALM1/IGF1/PPP1CA/MAPK13	-1.1470950468458
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/554	183/9376	0.64737330098045	RAN/RCL1/UTP14A/NOB1/PWP2/RPP30/FBL	-1.20717185205939
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/554	94/9376	0.540133650818035	HSP90B1/MMP3/MAPK13	-1.12287592317843
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/554	44/9376	0.384640630127995	MUTYH	-1.02523821274569
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/554	122/9376	0.554891400840386	CDC42/GRB2/MAP2K2/MAPK13	-1.24004700053938
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/554	48/9376	0.352587244283995	ATP1B3	-1.12684607343391
NA	NA	hsa04081	Hormone signaling	8/554	219/9376	0.618235168059608	LEP/CGA/GNAS/GNG11/GAST/IGF1/RAMP2/RAMP1	-1.43251231105261
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/554	51/9376	0.331846818149643	PLA2G2A	-1.19892965545616
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/554	115/9376	0.441500549364307	GNG11/CREB3/CREB3L1	-1.51007918815901
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/554	116/9376	0.437694510145649	GNAS/GNG11/SLC1A2	-1.52704845772849
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/554	168/9376	0.50369606326285	PYGL/VDAC2/SLC25A6/SHARPIN/IRF9	-1.62658476202225
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/554	93/9376	0.363961026357672	MAF/MAPK13	-1.54467821276478
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/554	66/9376	0.256427086751996	MAF	-1.51906963318994
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/554	158/9376	0.428460448750171	CCND2/CHEK2/ZBTB17/MYC	-1.81557199391084
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/554	142/9376	0.357553261809122	SOCS3/UBE2L3/RHOBTB2	-1.93305120989818
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9/554	298/9376	0.511133186344584	LEP/CXCL14/CCR7/ACVRL1/CCL4/IL1R2/CXCL12/LIFR/LTBR	-2.14911964079601
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/554	89/9376	0.190159412647548	GNG11	-1.92359576922928
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/554	323/9376	0.47157179421265	GRB2/PTEN/CCND2/ZEB1/MAP2K2/THBS1/TNXB/WNT3A/MYC	-2.42185415169032
NA	NA	hsa04082	Neuroactive ligand signaling	4/554	199/9376	0.340184677902146	GNAS/GNG11/SLC1A2/TACR3	-2.35752096007715
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/554	109/9376	0.155267777299374	MAPK13	-2.22289895747693
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/554	370/9376	0.274446287442677	LEP/CGA/NPW/TACR3/GZMA/C3	-3.56830076638897
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/554	449/9376	0.113079205293753	CALM3/CALM1/SLC8A1	-4.8262768908643