category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	81/642	222/9376	5.32861833796413	RPS18/RPLP0/RPL13/RPL6/RPS6/RPL18A/RPL37/RPL23A/RPS12/RPL37A/RPS11/RPS27/RPL36/RPL24/RPS3A/RPL32/RPS7/RPL8/RPL10A/RPS16/RPL9/RPL29/RPS23/RPL23/RPL34/RPS29/RPL21/RPL13A/RPL35/RPS4X/RPL31/RPS20/RPL7A/RPL18/RPL39/RPLP2/RPL7/RPS2/RPS3/RPS5/RPL27A/RPSA/RPS15/RPL38/RPL14/RPS14/RPL22/RPL3/RPL35A/RPL11/RPS13/RPS24/RPS27A/RPL27/RPL5/RPS25/RPL26/RPS15A/RPL4/RPS8/RPL15/RPS19/RPL30/RPS9/MRPS34/MRPL36/MRPL40/MRPS23/MRPL23/MRPS12/RPL10/MRPS25/MRPL45/MRPL28/RPLP1/RPL12/MRPS5/MRPL35/MRPS18A/MRPL19/MRPL37	17.6956649433153
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	80/642	238/9376	4.90902903217362	RPS18/F13A1/RPLP0/RPL13/CCL2/RPL6/RPS6/RPL18A/RPL37/RPL23A/RPS12/RPL37A/RPS11/RPS27/RPL36/RPL24/RPS3A/RPL32/RPS7/RPL8/RPL10A/RPS16/RPL9/RPL29/RPS23/RPL23/RPL34/RPS29/RPL21/RPL13A/RPL35/RPS4X/RPL31/RPS20/RPL7A/RPL18/RPL39/RPLP2/RPL7/RPS2/RPS3/RPS5/RPL27A/RPSA/RPS15/RPL38/RPL14/RPS14/RPL22/RPL3/RPL35A/RPL11/RPS13/RPS24/RPS27A/PRKCA/RPL27/RPL5/RPS25/RPL26/NRP1/RPS15A/RPL4/RPS8/RPL15/RPS19/RPL30/C9/ADAR/RPS9/MX2/C3AR1/MAPK1/RPL10/SYK/RELA/MAPK3/RPLP1/RPL12/TAB2	16.5606872683307
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	28/642	158/9376	2.58811467329153	CDKN1C/CCNB1/CCNE1/CDC20/CCND1/CDK1/CCNB2/WEE1/CCNA2/PTTG1/CDT1/AURKB/PLK1/CDC6/CDCA5/MAD2L1/YWHAE/PKMYT1/PPP2CA/HDAC2/ATM/CDC45/SKP2/RAD21/EP300/YWHAG/CDC25C/CDC27	5.45806380683055
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	36/642	268/9376	1.96177988561864	MT-CO3/CALM1/MT-ATP6/TUBA1B/MT-ND1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/MT-ND2/MT-ND5/RPS27A/HSPA5/MT-CO1/TUBA1C/TUBB4B/PSMA7/GNAI1/UBB/TUBB/COX8C/SLC39A7/PSMA5/UQCRFS1/PSMD9/PSMC6/SLC39A1/NDUFA9/NDUFS4/NDUFA4/PSMD6/NDUFB6/PSMD2/NDUFB3/UBE2J2/CAMK2D	4.33089978635479
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	29/642	205/9376	2.06598282805258	MT-CO3/GAPDH/MT-ATP6/MT-ND1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/MT-ND2/SLC2A1/MT-ND5/PRKCA/MT-CO1/MMP2/COX8C/NCF4/PDHA1/UQCRFS1/COL1A1/NDUFA9/NDUFS4/NDUFA4/RELA/NDUFB6/COL3A1/CPT2/NDUFB3/CAMK2D/SP1	4.18374639291072
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	22/642	138/9376	2.32823152286785	CCNB1/CCNE1/CDC20/CALM1/IGF1/CDK1/CCNB2/PTTG1/PLK1/MAD2L1/MAPK1/YWHAE/PKMYT1/PPP2CA/PPP3CA/MAPK3/SLK/CAMK2D/YWHAG/CDC25C/RPS6KA3/CDC27	4.26158255335218
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	25/642	170/9376	2.14770020157596	TUBA1B/CCND1/CLDN10/ACTB/CLDN4/CLDN3/EZR/TUBA1C/CLDN6/JAM3/MYL6/MYH10/CLDN7/MAGI1/CTTN/PPP2CA/CD1C/TJP3/CLDN19/HCLS1/HSPA4/RAB8B/CD1E/PARD3/ROCK2	4.09415227784431
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	35/642	275/9376	1.85873690172756	MT-CO3/MT-ATP6/TUBA1B/MT-ND1/CAV1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/MT-ND2/MT-ND5/HSPA5/MT-CO1/TUBA1C/TUBB4B/PSMA7/EGR1/C9/TUBB/COX8C/NCF4/MAPK1/PSMA5/UQCRFS1/PSMD9/PSMC6/NDUFA9/NDUFS4/PPP3CA/NDUFA4/MAPK3/PSMD6/NDUFB6/PSMD2/NDUFB3	3.91857780256815
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	43/642	368/9376	1.70648787755655	MT-CO3/MT-ATP6/TUBA1B/MT-ND1/MT-CYB/HNRNPA2B1/MT-CO2/MT-ND3/MT-ND4/ACTB/HNRNPA1/MT-ND2/MT-ND5/HSPA5/MT-CO1/TUBA1C/SRSF3/TUBB4B/HNRNPA3/PSMA7/SETX/TUBB/FUS/COX8C/DNALI1/RAE1/ACTR10/PSMA5/UQCRFS1/PSMD9/GPX8/NUP62/PSMC6/NDUFA9/NDUFS4/PPP3CA/NDUFA4/PSMD6/NDUFB6/PFN1/PSMD2/NDUFB3/DCTN6	3.7485300208169
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	18/642	110/9376	2.38980458793543	CCNB1/IGF1/CDK1/CCNB2/CCNA2/HSP90AB1/PLK1/GNAI1/MAD2L1/MAPK1/HSP90AA1/PKMYT1/MAPK3/KRAS/STK10/CDC25C/RPS6KA3/CDC27	3.97512229308906
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	14/642	75/9376	2.72614745586708	CCNB1/RRM2/CCNE1/CCND1/IGF1/PERP/CDK1/GTSE1/CCNB2/IGFBP3/ATM/CCNG2/SESN3/PMAIP1	4.06902408455235
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	27/642	200/9376	1.97158878504673	GAPDH/TUBA1B/CLDN10/RPS3/ACTB/CLDN4/CLDN3/MYO1B/EZR/TUBA1C/CLDN6/TUBB4B/MYH10/TUBB/CLDN7/MAPK1/CTTN/NCKAP1/CLDN19/HCLS1/RELA/MAPK3/WIPF2/TAB2/BAIAP2L1/WIPF1/ROCK2	3.76545400418278
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/642	106/9376	2.34220889907718	CCNE1/FOLR2/CCND1/IGF1/ETV5/HSP90AB1/HSP90B1/FOLR1/PDPK1/MAPK1/HSP90AA1/SOS2/TCF7L2/RELA/MAPK3/EP300/KRAS	3.76772969428201
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	22/642	157/9376	2.0464710201004	HLA-G/CCNB1/CCNE1/CALM1/CCND1/CDK1/ZFP36L1/CCNB2/CCNA2/IGFBP3/MYBL2/MAPK1/CAPN1/ATM/TRPM7/PPP3CA/RELA/MAPK3/KRAS/HIPK1/FOXM1/NFATC2	3.58493828035942
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	26/642	204/9376	1.86134017469916	RPS6/CAV1/CCND1/IGF1/ACTB/PRKCA/EZR/MMP2/IGF2/CBL/VAV1/PDPK1/MAPK1/FZD3/CTTN/SOS2/PPP1R12A/COL1A1/PDCD4/HCLS1/MAPK3/NUDT16L1/GPC1/KRAS/CAMK2D/ROCK2	3.37213011119093
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/642	184/9376	1.90491670052824	PRKCA/RAC3/EFNA2/NRP1/EPHB4/GNAI1/BOC/ENAH/EFNA1/PDPK1/MAPK1/FZD3/PLXNB2/FES/PPP3CA/MAPK3/PARD3/LRRC4/SSH2/KRAS/CAMK2D/BMP7/ROCK2/NFATC2	3.36092689032362
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/642	133/9376	2.08633733867379	CCNB1/CCND1/IGF1/CCNB2/PLK1/PDPK1/BNIP3/MAPK1/SOS2/ATM/SKP2/PLK3/MAPK3/G6PC3/CCNG2/EP300/USP7/KRAS/ATG12	3.42082304627769
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	35/642	308/9376	1.6595865193996	MT-CO3/MT-ATP6/TUBA1B/MT-ND1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/MT-ND2/MT-ND5/MT-CO1/TUBA1C/TUBB4B/PSMA7/TUBB/COX8C/POLR2E/DNALI1/HDAC2/ACTR10/PSMA5/UQCRFS1/PSMD9/GPX8/PSMC6/NDUFA9/NDUFS4/NDUFA4/PSMD6/NDUFB6/EP300/PSMD2/NDUFB3/DCTN6/SP1	3.19108176268258
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	27/642	224/9376	1.76034712950601	HLA-G/HLA-DRB5/CCNE1/CDC20/CCND1/IL2RA/SLC2A1/CCNB2/CCNA2/PTTG1/NRP1/MSX2/CALR/RANBP1/RAN/EGR1/MAD2L1/MAPK1/ATM/PPP3CA/RELA/MAPK3/EP300/XIAP/KRAS/CDC27/NFATC2	3.12265836382547
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	25/642	203/9376	1.79856667127051	PGF/CAV1/CCND1/IGF1/LAMA4/ACTB/PRKCA/RAC3/COL4A1/BIRC2/VAV1/PDPK1/LAMB1/MAPK1/PARVA/SOS2/PPP1R12A/COL4A2/COL1A1/MAPK3/COL6A3/XIAP/FLT4/FLNB/ROCK2	3.11853096952006
Cellular Processes	Cell motility	hsa04814	Motor proteins	24/642	194/9376	1.80672511802678	TPM1/TUBA1B/ACTB/MYL4/MYO1B/TUBA1C/KIF23/KIF14/TUBB4B/KIF4A/KIF2C/TPM2/MYL6/MYH10/TUBB/TPM4/DNALI1/KIF20A/ACTR10/DYNLT3/DYNC1LI2/DYNC1I2/DYNC1H1/DCTN6	3.07825333349079
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/642	30/9376	3.40768431983385	FOLR2/ABCG2/TYMS/FOLR1/RELA/MTHFR/MTR	3.58091359460752
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/642	103/9376	2.12684874330823	LAMA4/PRKCA/COL4A1/CD14/SERPINB9/C9/ARG2/LAMB1/CD1C/COL4A2/COL1A1/RELA/CD1E/COL3A1/GNA15	3.11760195838455
NA	NA	hsa04981	Folate transport and metabolism	7/642	31/9376	3.29775901919405	FOLR2/ABCG2/TYMS/FOLR1/MTHFS/MTHFR/MTR	3.47409933418775
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/642	39/9376	2.99576643501877	GCSH/TYMS/MAT2B/GLDC/MTHFS/MTHFD2/MTHFR/MTR	3.38598396350888
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	48/642	480/9376	1.46043613707165	MT-CO3/CALM1/MT-ATP6/TUBA1B/MT-ND1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/MT-ND2/MT-ND5/RPS27A/PRKCA/HSPA5/MT-CO1/TUBA1C/TUBB4B/PSMA7/UBB/TUBB/FUS/COX8C/DNALI1/MAPK1/FZD3/ATXN3/CAPN1/ACTR10/PSMA5/UQCRFS1/PSMD9/GPX8/PSMC6/APP/NDUFA9/NDUFS4/PPP3CA/NDUFA4/RELA/MAPK3/PSMD6/NDUFB6/KRAS/PSMD2/NDUFB3/UBE2J2/CAMK2D/DCTN6	2.80762558705924
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	18/642	138/9376	1.90491670052824	MT-CO3/MT-ATP6/MT-ND1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/MT-ND2/MT-ND5/MT-CO1/COX8C/UQCRFS1/NDUFA9/NDUFS4/ATP6V1E1/NDUFA4/NDUFB6/NDUFB3	2.90339233545796
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/642	68/9376	2.36247022173355	CCND1/DUSP6/CCNA2/CD14/CSF1R/MAPK1/SOS2/TCF7L2/RELA/MAPK3/KRAS	3.05703102692773
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	23/642	193/9376	1.74041612189886	CCL2/CX3CR1/CCL4L2/CXCL14/CCL4/CCL3L1/RAC3/GNAI1/PREX1/CCL4L1/CCL8/HCK/GNG2/VAV1/MAPK1/SOS2/RELA/MAPK3/PARD3/KRAS/LYN/ARRB1/ROCK2	2.81779106282633
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/642	69/9376	2.32823152286785	FCER1A/PRKCA/RAC3/VAV1/PDPK1/MAPK1/SOS2/SYK/MAPK3/KRAS/LYN	3.00220282978849
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/642	110/9376	1.99150382327952	RPS6/GAPDH/IGF1/SLC2A1/PRKCA/ENO1/PDHA1/MAPK1/PFKL/RELA/MAPK3/EP300/LDHA/EIF4E2/CAMK2D	2.83590152588026
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	37/642	362/9376	1.49271096883014	RPS6/CCNE1/PGF/CCND1/IGF1/LAMA4/IL2RA/PRKCA/EFNA2/IGF2/COL4A1/HSP90AB1/HSP90B1/EFNA1/GNG2/PDPK1/LAMB1/CSF1R/MAPK1/MAGI1/HSP90AA1/YWHAE/SOS2/PPP2CA/MCL1/SYK/CDC37/COL4A2/COL1A1/RELA/MAPK3/G6PC3/COL6A3/FLT4/KRAS/EIF4E2/YWHAG	2.59199582443315
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	39/642	388/9376	1.46796415839676	MT-CO3/CALM1/GAPDH/MT-ATP6/TUBA1B/MT-ND1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/MT-ND2/MT-ND5/MT-CO1/TUBA1C/TUBB4B/PSMA7/TUBB/COX8C/MAPK1/FZD3/SLC39A7/CAPN1/PSMA5/UQCRFS1/PSMD9/PSMC6/APP/SLC39A1/NDUFA9/NDUFS4/PPP3CA/NDUFA4/RELA/MAPK3/PSMD6/NDUFB6/KRAS/PSMD2/NDUFB3	2.55236911555715
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/642	248/9376	1.58999095568285	GAPDH/TUBA1B/RPS3/ACTB/TUBA1C/TUBB4B/CD14/HSP90AB1/HSP90B1/BIRC2/TUBB/MAPK1/GSDMD/HSP90AA1/ACTR10/TCF7L2/DYNLT3/NCKAP1/RELA/MAPK3/TAB2/DYNC1LI2/DYNC1I2/PFN1/DYNC1H1/DCTN6/ROCK2	2.5528772744771
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	25/642	227/9376	1.60840984258992	MT-CO3/MT-ATP6/MT-ND1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/MT-ND2/MT-ND5/MT-CO1/AHR/GSTA4/COX8C/PDPK1/MAPK1/SOS2/UQCRFS1/NDUFA9/NDUFS4/NDUFA4/RELA/MAPK3/NDUFB6/KRAS/NDUFB3	2.51575824390051
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/642	116/9376	1.88849500483403	CLDN10/ACTB/CLDN4/PRKCA/CLDN3/EZR/MMP2/CLDN6/GNAI1/JAM3/CLDN7/NCF4/VAV1/CLDN19/ROCK2	2.61050813088885
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	24/642	216/9376	1.6227068189685	CCL2/CALM1/PRKCA/CCL3L1/HSPA5/CD14/HSP90AB1/HSP90B1/NCF4/VAV1/PDPK1/MAPK1/HSP90AA1/HSPA4/PPP3CA/RELA/MAPK3/TAB2/KRAS/CAMK2D/LYN/ROCK2/HSPA2/NFATC2	2.510205742063
NA	NA	hsa03272	Virion - Hepatitis viruses	8/642	48/9376	2.43406022845275	CLDN10/CLDN4/EPCAM/CLDN3/CLDN6/DPP4/CLDN7/CLDN19	2.70047586293274
Genetic Information Processing	Transcription	hsa03040	Spliceosome	26/642	243/9376	1.56260656641411	HNRNPA1/SRSF3/HNRNPA3/SNRPD2/NCBP2/TRA2B/BUD31/FUS/RBM17/CWC15/SRSF2/CDC5L/WBP11/RBM8A/CCDC12/SNRNP27/LSM6/ZMAT2/SF3A1/DDX42/SNRPF/PRPF38A/SNRNP200/RBM22/THOC2/SRSF4	2.40906081233228
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	17/642	142/9376	1.74840945987451	UBE2C/CDC20/RPS27A/UBB/CBL/BIRC2/SKP2/HUWE1/CDC34/UBE2F/HERC4/XIAP/TRIP12/UBE2J2/UBE2Z/CDC27/ITCH	2.43632411462625
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	25/642	235/9376	1.55365546496984	RPS6/MT-CO3/MT-ATP6/MT-ND1/MT-CYB/MT-CO2/MT-ND3/MT-ND4/ACTB/MT-ND2/MT-ND5/MT-CO1/COX8C/SOS2/UQCRFS1/COX16/COA6/NDUFA9/NDUFS4/NDUFA4/NDUFB6/CPT2/KRAS/NDUFB3/RPS6KA3	2.33036112165392
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/642	122/9376	1.7956182013176	CCND1/ACTB/SLC2A1/DIO2/PRKCA/BMP4/PDPK1/MAPK1/HDAC2/PFKL/MAPK3/MED13L/EP300/KRAS/MED13	2.3980952899686
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/642	101/9376	1.87976928533975	CCL2/CCND1/PRKCA/MMP2/COL4A1/EGR1/MAPK1/COL4A2/COL1A1/RELA/MAPK3/COL3A1/KRAS	2.41001131687454
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/642	91/9376	1.9258498510835	RAC3/VAV1/MAPK1/SOS2/SYK/INPPL1/PPP3CA/RELA/MAPK3/KRAS/LYN/NFATC2	2.40611766520994
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	22/642	205/9376	1.56729731783299	HLA-G/CCNE1/CDC20/CCND1/CDK1/CCNA2/EGR3/RANBP1/SND1/MAPK1/YWHAE/HDAC2/SYK/SKP2/RELA/MAPK3/EP300/USP7/KRAS/PMAIP1/LYN/YWHAG	2.22651626717821
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/642	137/9376	1.70561884621507	TUBA1B/BIRC5/ACTB/TUBA1C/BIRC2/PDPK1/MAPK1/CAPN1/ATM/MCL1/RELA/MAPK3/XIAP/KRAS/PMAIP1/LMNB2	2.25561269502972
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	24/642	233/9376	1.50431190084634	TPM1/DSP/ACTB/MYL4/DSG2/COL4A1/FHL2/PKP2/DIAPH3/TPM2/SYNE2/MYH10/ENO1/CSRP2/TPM4/FBLN1/COL4A2/COL1A1/PLEC/EMD/COL6A3/COL3A1/LMNB2/PDLIM1	2.11338867534041
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/642	75/9376	1.9472481827622	TOP2A/BIRC5/GSTA4/BIRC2/PDPK1/MAPK1/ATM/MAPK3/XIAP/PMAIP1	2.23293534779258
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/642	130/9376	1.68511861969806	PRKCA/MMP2/COL4A1/GNAI1/GNG2/MAPK1/SOS2/COL4A2/COL1A1/RELA/MAPK3/COL3A1/KRAS/GNA15/ARRB1	2.13258848894735
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/642	87/9376	1.84652844917105	TPM1/MT-CO3/MT-CYB/MT-CO2/MYL4/MT-CO1/TPM2/COX8C/TPM4/UQCRFS1/ASPH	2.1506179251665
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/642	46/9376	2.22240281728295	PSMA7/PSMA5/PSMD9/PSME4/PSMC6/PSMD6/PSMD2	2.25319611924686
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/642	155/9376	1.60176866646568	HLA-G/HLA-DRB5/TUBA1B/CD209/ACTB/COLEC12/TUBA1C/CALR/TUBB4B/CD14/MRC1/TUBB/NCF4/ATP6V1E1/DYNC1LI2/DYNC1I2/DYNC1H1	2.04810853408502
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/642	214/9376	1.5013829446531	HLA-G/CCNB1/CALM1/CDK1/PRKCA/RAC3/CCNB2/WEE1/CALR/GNAI1/AP1M2/GNG2/MAPK1/ATM/PPP3CA/RELA/MAPK3/TAB2/KRAS/CDC25C/AP1B1/NFATC2	2.01153622509655
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/642	156/9376	1.59150091860372	CCND1/CLDN10/CLDN4/CLDN3/CLDN6/CLDN7/MX2/IFIT1/MAPK1/YWHAE/SOS2/PPP2CA/CLDN19/RELA/MAPK3/KRAS/YWHAG	2.01975559805903
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/642	67/9376	1.96177988561864	CALM1/PRKCA/MAPK1/PPP3CA/MAPK3/EP300/KRAS/CAMK2D/RPS6KA3	2.14194411108197
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/642	89/9376	1.80503342784137	TUBA1B/CDK1/PRKCA/TUBA1C/TUBB4B/GNAI1/TUBB/MAPK1/SOS2/MAPK3/KRAS	2.06879640655379
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/642	38/9376	2.30595179537629	IGF1/PRKCA/PDPK1/MAPK1/MAPK3/KRAS	2.18694856387904
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/642	115/9376	1.65092780712448	PDE4C/PRKCA/GATA3/GNAI1/EGR1/NACA/GCM1/MMP15/MAPK1/WNK1/MAPK3/ARRB1/SP1	1.90414212594154
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/642	60/9376	1.9472481827622	IGF1/PRKCA/GNAI1/MAPK1/PPP2CA/MAPK3/KRAS/LYN	1.99558956568384
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/642	21/9376	2.78178311823172	DSEL/CHSY1/B3GAT3/B4GALT7	2.21609895894192
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/642	174/9376	1.51079600386723	TUSC3/HSPA5/PDIA6/CALR/HSP90AB1/HSP90B1/CRYAB/SAR1B/BAG1/STT3B/ATXN3/HSP90AA1/CAPN1/DERL2/ERLEC1/DNAJC3/SEC31A/UBE2J2	1.84385837004839
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/642	93/9376	1.7273975814826	CCNE1/CCND1/LAMA4/CKS1B/COL4A1/BIRC2/LAMB1/SKP2/COL4A2/RELA/XIAP	1.91124213052596
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/642	94/9376	1.70902101146683	CCL2/FOSB/HSP90AB1/HSP90B1/MAPK1/HSP90AA1/USP25/RELA/MAPK3/TAB2/IL17RA	1.87304757570341
NA	NA	hsa04518	Integrin signaling	16/642	154/9376	1.51733624630821	PGF/CCND1/IGF1/LAMA4/ACTB/FERMT2/RAC3/COL4A1/FERMT1/LAMB1/PARVA/COL4A2/COL1A1/COL6A3/FLT4/FLNB	1.75496018296722
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	22/642	227/9376	1.41540066147913	HLA-G/CCL2/CALM1/CCND1/CCL4L2/CCL4/PRKCA/CCL3L1/RAC3/CALR/GNAI1/CCL4L1/GNG2/MAPK1/SOS2/PPP3CA/RELA/MAPK3/KRAS/ROCK2/SP1/NFATC2	1.71767050018326
NA	NA	hsa04382	Cornified envelope formation	21/642	217/9376	1.41332529394031	KRT19/KRT18/KRT7/KRT8/DSP/CLDN10/KRT23/CLDN4/CLDN3/DSG2/CLDN6/COL4A1/PKP2/CLDN7/PADI1/PKP3/PPP2CA/CAPN1/COL4A2/PLEC/CLDN19	1.6701073184779
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/642	75/9376	1.75252336448598	GAPDH/PHGDH/ARG2/ACO2/ENO1/MAT2B/PFKL/RPE/MTR	1.77391316360264
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/642	157/9376	1.48834256007302	CCND1/BIRC5/ACTB/BMP4/TEAD4/ID1/BIRC2/TEAD1/FZD3/YWHAE/PPP2CA/TCF7L2/PARD3/YAP1/YWHAG/BMP7	1.67293494411964
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/642	110/9376	1.59320305862362	GREM2/ID4/BMP4/NBL1/ID1/MAPK1/PPP2CA/HDAC2/MAPK3/EP300/BMP7/SP1	1.69668075867146
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/642	54/9376	1.89315795546325	PHGDH/MAT2B/TST/MPST/LDHA/ENOPH1/MTR	1.78450249683777
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/642	76/9376	1.72946384653222	CALM1/CCND1/IGF1/PRKCA/MAPK1/SOS2/MAPK3/KRAS/CAMK2D	1.7310740764922
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	16/642	158/9376	1.4789226704523	RPS6/IGF1/PRKCA/PDPK1/MAPK1/FZD3/SOS2/SKP2/ATP6V1E1/MAPK3/LAMTOR3/KRAS/EIF4E2/PRR5/RPS6KA3/RRAGA	1.64597087214652
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/642	149/9376	1.47023772188421	MT-ND1/MT-ND3/MT-ND4/MT-ND2/MT-ND5/PRKCA/GNAI1/GNG2/MAPK1/NDUFA9/NDUFS4/NDUFA4/MAPK3/NDUFB6/NDUFB3	1.56865304581057
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/642	125/9376	1.51885358255452	FCER1A/PRKCA/RAC3/GNAI1/PDPK1/MAPK1/PPP2CA/SPTSSA/RELA/MAPK3/KRAS/ROCK2/SGMS1	1.58325928727054
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/642	67/9376	1.74380434277212	GAPDH/ENO1/PDHA1/PFKL/G6PC3/LDHA/GPI/PGM2	1.65649890959527
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	20/642	212/9376	1.37776994063363	CALM1/PGF/IGF1/ACTB/PRKCA/RAC3/EFNA2/GNAI1/ENAH/ID1/EFNA1/VAV1/CSF1R/MAPK1/MAGI1/MAPK3/PARD3/FLT4/PFN1/KRAS	1.50834034106057
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/642	138/9376	1.48160187818863	RPS6/CALM1/CBL/PDPK1/MAPK1/SOS2/PRKAR2A/INPPL1/MAPK3/G6PC3/PHKB/KRAS/EIF4E2/FLOT1	1.54520211756374
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/642	139/9376	1.47094287187073	KRT19/KRT18/CALM1/KRT23/MMP2/HSP90AB1/HSP90B1/GNAI1/MAPK1/HSP90AA1/SOS2/MAPK3/KRAS/SP1	1.51654993446145
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	19/642	201/9376	1.38051177136126	IGF1/DUSP6/MAF/CCNA2/ETV5/CD14/IGFBP3/MYCN/BIRC2/FUS/HMGA2/CSF1R/HDAC2/ATM/KLF3/HPGD/RELA/ASPSCR1/SP1	1.47846023169525
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/642	80/9376	1.64299065420561	RPS6/IGF1/PRKCA/GAS6/MAPK1/SOS2/MAPK3/KRAS/EIF4E2	1.5658427829666
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/642	93/9376	1.57036143771145	ACTB/ARHGAP29/RAC3/MAPK1/TCF7L2/MAPK3/EP300/PARD3/ROCK2/YES1	1.49862858652846
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/642	93/9376	1.57036143771145	HLA-DRB5/MAF/IL2RA/GATA3/MAPK1/MAML2/PPP3CA/RELA/MAPK3/NFATC2	1.49862858652846
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/642	93/9376	1.57036143771145	CGA/CALM1/PRKCA/MMP2/EGR1/MAPK1/SOS2/MAPK3/KRAS/CAMK2D	1.49862858652846
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/642	105/9376	1.52998071502744	CCL4L2/CCL4/CD14/CCL4L1/BIRC2/ATM/SYK/RELA/TAB2/XIAP/LYN	1.48060081529452
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/642	105/9376	1.52998071502744	CALM1/CD209/EGR3/MAPK1/SYK/PPP3CA/PLK3/RELA/MAPK3/KRAS/NFATC2	1.48060081529452
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/642	37/9376	1.97356234739412	CCND1/MAPK1/TCF7L2/MAPK3/KRAS	1.60864792070779
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/642	59/9376	1.73272084059348	CCND1/PDPK1/MAPK1/SOS2/TCF7L2/MAPK3/KRAS	1.5306400079744
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/642	82/9376	1.6029177114201	HLA-G/HLA-DRB5/HSPA5/CALR/HSP90AB1/HSP90AA1/HSPA4/RFXANK/HSPA2	1.48665498866863
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/642	71/9376	1.64556184458778	SLC2A1/PDHA1/MAPK1/PFKL/MAPK3/GLS/LDHA/KRAS	1.48031928815832
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/642	60/9376	1.70384215991693	PRKCA/RAC3/MAPK1/PPP3CA/MAPK3/KRAS/NFATC2	1.48280049070435
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	15/642	157/9376	1.39532115006846	LEP/MT-CO3/MT-CYB/MT-CO2/MT-CO1/MLXIPL/COX8C/UQCRFS1/NDUFA9/NDUFS4/NDUFA4/RELA/NDUFB6/NDUFB3/ITCH	1.35426772141301
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/642	108/9376	1.48748125072113	RAN/NCBP2/RAE1/RBM8A/IPO7/NUP62/UPF3B/SAP18/IPO8/THOC2/UPF2	1.38141236912714
NA	NA	hsa04517	IgSF CAM signaling	26/642	299/9376	1.26994446701883	TUBA1B/CD209/ACTB/PRKCA/EZR/TUBA1C/NRP1/TUBB4B/MTSS1/JAM3/CNTNAP2/MYL6/MYH10/KCNQ3/TUBB/VAV1/PDPK1/MAPK1/MAGI1/EPB41L3/NPHS1/APP/CSK/MAPK3/PARD3/LYN	1.28613161856207
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	18/642	196/9376	1.34121686057601	HLA-G/CALM1/CCND1/RPS27A/PREX1/UBB/HCK/GNG2/MAPK1/SYK/TCF7L2/PPP3CA/RELA/MAPK3/EP300/KRAS/LYN/NFATC2	1.30883149288072
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/642	109/9376	1.47383463374203	CCL4L2/CCL4/CCL3L1/CD14/CCL4L1/IRF5/MAPK1/TLR1/RELA/MAPK3/TAB2	1.34901577154453
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/642	109/9376	1.47383463374203	HLA-DRB5/IL2RA/GATA3/AHR/HSP90AB1/MAPK1/HSP90AA1/PPP3CA/RELA/MAPK3/NFATC2	1.34901577154453
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/642	85/9376	1.54634414513469	RRM2/TYMS/TK1/AK1/ITPA/NT5C2/NT5C/ADK/NTPCR	1.37180090365029
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/642	98/9376	1.49024095619556	PRKCA/BIN1/HCK/VAV1/MAPK1/SYK/INPPL1/MAPK3/LYN/ASAP1	1.32264106638203
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/642	19/9376	2.30595179537629	GCSH/GLDC/PDHA1	1.54483532241389
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/642	99/9376	1.47518801724409	PRKCA/RAC3/PDPK1/SLC44A1/MAPK1/DGKZ/SOS2/MAPK3/KRAS/SP1	1.28862293892194
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/642	87/9376	1.51079600386723	CCND1/BIRC5/RAC3/MAPK1/SOS2/TCF7L2/MAPK3/KRAS/PMAIP1	1.29768473002412
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/642	112/9376	1.43435692033823	HLA-DRB5/LAMA4/GNAI1/BIRC2/PDPK1/LAMB1/MAPK1/RELA/MAPK3/TAB2/XIAP	1.25372718185289
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/642	100/9376	1.46043613707165	CCL2/CX3CR1/CCL4L2/CXCL14/IL2RA/CCL4/CCL3L1/CCL4L1/CCL8/CSF1R	1.25497649011471
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/642	41/9376	1.78101967935567	ALAS2/GCSH/PHGDH/GLDC/GAMT	1.3587617183604
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/642	41/9376	1.78101967935567	RAD54L/BABAM1/ATM/XRCC2/RPA2	1.3587617183604
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/642	41/9376	1.78101967935567	CCND1/MMP2/MAPK1/MAPK3/KRAS	1.3587617183604
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/642	10/9376	2.9208722741433	TST/MPST	1.64766140819984
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/642	138/9376	1.37577317260373	CCL2/ACTB/RAC3/VAV1/MAPK1/RELA/MAPK3/WIPF2/TAB2/WIPF1/RPS6KA3/ROCK2/NFATC2	1.20565456309019
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/642	101/9376	1.44597637333827	CALM1/PRKCA/GNAI1/MAPK1/FZD3/TCF7L2/MAPK3/EP300/KRAS/CAMK2D	1.22169314695821
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/642	65/9376	1.57277737838486	CGA/PRKCA/MAPK1/KISS1/MAPK3/KRAS/ARRB1	1.25629297360671
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/642	77/9376	1.51733624630821	CCND1/CBL/MAPK1/SOS2/HDAC2/RELA/MAPK3/KRAS	1.23579577123805
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/642	31/9376	1.88443372525374	PFKL/RPE/GPI/PGM2	1.33722056593861
NA	NA	hsa04519	Cadherin signaling	33/642	404/9376	1.19293050800407	KRT19/KRT18/KRT7/KRT8/DSP/PCDH12/ACTB/KRT23/RAC3/MYO1B/DSG2/PKP2/ENAH/TEAD4/LIMA1/TEAD1/PKP3/VAV1/TAOK1/MAPK1/FZD3/YWHAE/TCF7L2/NCKAP1/RELA/MAPK3/SHOC2/EP300/FLT4/KRAS/YAP1/YWHAG/ROCK2	1.07471550960931
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/642	154/9376	1.32766921551968	CALM1/CCND1/ACTB/PRKCA/GNAI1/MYL6/MAPK1/PPP1R12A/PPP3CA/MAPK3/KRAS/CAMK2D/ROCK2/NFATC2	1.11155255508341
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/642	32/9376	1.82554517133956	BIRC5/BIRC2/XIAP/PMAIP1	1.26822401952939
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/642	142/9376	1.33701899872757	CCL2/CALM1/CAV1/ACTB/RAC3/MMP2/HSP90AB1/HSP90B1/BMP4/GSTA4/HSP90AA1/RELA/GPC1	1.09711001491729
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/642	105/9376	1.39089155911586	RPS27A/UBB/BNIP3/HUWE1/RELA/ARIH1/FUNDC1/KRAS/CCZ1/SP1	1.09202909598082
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	21/642	250/9376	1.22676635514019	HLA-G/FOLR2/CAV1/DAB2/IL2RA/BIN1/FOLR1/CBL/ARFGAP3/AGAP1/EPN1/RAB22A/WIPF2/WIPF1/PARD3/ARFGEF1/ARRB1/ASAP1/IQSEC1/ARFGAP2/ITCH	0.985269298537292
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/642	107/9376	1.36489358604827	CALM1/SLC2A1/PDHA1/PFKL/PPP3CA/G6PC3/PHKB/EP300/LDHA/CAMK2D	1.02917264847672
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	11/642	120/9376	1.33873312564901	CALM1/PDPK1/MAPK1/YWHAE/SOS2/RELA/MAPK3/KRAS/CAMK2D/RPS6KA3/SORT1	1.012472364783
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/642	133/9376	1.31768674021502	HLA-G/PRKCA/RAC3/VAV1/MAPK1/SOS2/HCST/SYK/PPP3CA/MAPK3/KRAS/NFATC2	1.00037997750414
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/642	70/9376	1.46043613707165	HLA-G/HLA-DRB5/CAV1/CCND1/ACTB/RAC3/EIF4G3	1.04829485911965
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/642	134/9376	1.30785325707909	CALM1/CALD1/PLA2G2A/PRKCA/PPP1R14A/MYL6/MYH10/RAMP1/MAPK1/PPP1R12A/MAPK3/ROCK2	0.973105054352855
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/642	83/9376	1.40764928874376	CCL4L2/CCL4/CCL4L1/ADAR/POLR2E/GSDMD/RELA/POLR3K	1.01133334087419
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/642	187/9376	1.24957102637147	CCL2/HSP90AB1/BIRC2/MAPK1/GSDMD/HSP90AA1/YWHAE/TRPM7/CARD8/RELA/MAPK3/TAB2/XIAP/SUGT1/NEK7/ATG12	0.934603495566592
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/642	71/9376	1.4398666140143	CGA/CCND1/MAPK1/SOS2/RELA/MAPK3/KRAS	1.00864547432795
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/642	217/9376	1.21142168052026	CCND1/BIRC5/PRKCA/AHR/HSP90AB1/HSP90B1/GNAI1/CDC6/GSTA4/MAPK1/HSP90AA1/SOS2/RELA/MAPK3/XIAP/KRAS/ARRB1/RPS6KA3	0.854283299615298
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/642	73/9376	1.40041821363035	CCND1/PRKCA/PDPK1/MAPK1/SOS2/MAPK3/KRAS	0.931129962377604
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/642	61/9376	1.43649456105408	MT1E/MT1H/SLC40A1/MT1G/TRPM7/HMOX2	0.927254357422692
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	17/642	205/9376	1.21109338196186	HLA-G/HLA-DRB5/CCNE1/CCND1/CCNA2/CALR/HDAC2/SYK/SKP2/PSMC6/RELA/PSMD6/TAB2/USP7/NCOR2/PSMD2/LYN	0.82849474879785
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	24/642	300/9376	1.16834890965732	PGF/IGF1/DUSP6/PRKCA/RAC3/EFNA2/IGF2/CD14/EFNA1/TAOK1/DUSP3/CSF1R/MAPK1/SOS2/PPP3CA/RELA/MAPK3/TAB2/LAMTOR3/FLT4/KRAS/ARRB1/ECSIT/RPS6KA3	0.803471081258827
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/642	37/9376	1.5788498779153	HBA2/HBA1/LAMA4/PRKCA	0.956451998172276
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/642	62/9376	1.41332529394031	HDAC2/MAML2/EP300/DTX2/NCOR2/ITCH	0.88525068128716
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/642	50/9376	1.46043613707165	HBA2/HBA1/CCL2/GYPA/GYPB	0.885020349596298
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	15/642	181/9376	1.21030619094336	HLA-DRB5/CALM1/CD209/CD14/MRC1/MAPK1/SYK/TLR1/PPP3CA/PLK3/RELA/MAPK3/EP300/CAMK2D/RFXANK	0.77457243338855
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/642	76/9376	1.34513854730284	GAST/CALM1/ACTB/PRKCA/EZR/GNAI1/CAMK2D	0.819040443024519
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	26/642	333/9376	1.14028046738327	HLA-G/CCNE1/CCND1/LAMA4/CCNA2/COL4A1/MX2/LAMB1/MAPK1/FZD3/MAGI1/SOS2/PPP2CA/HDAC2/ATM/MAML2/COL4A2/TCF7L2/COL1A1/ATP6V1E1/RELA/MAPK3/EP300/COL6A3/PARD3/KRAS	0.706658543522324
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/642	116/9376	1.25899666988935	GAPDH/GCSH/PHGDH/ACO2/ENO1/GLDC/PDHA1/PFKL/RPE/GPI	0.760964224830493
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/642	103/9376	1.27610924598494	NCBP2/FUS/SSU72/PPP2CA/RBM8A/UPF3B/GSPT1/SAP18/UPF2	0.763899086831805
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/642	103/9376	1.27610924598494	CCL2/CCL3L1/CALR/GNAI1/MAPK1/PPP2CA/RELA/MAPK3/GNA15	0.763899086831805
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/642	15/9376	1.9472481827622	AK1/NTPCR	0.995393604718806
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/642	27/9376	1.6227068189685	ELOVL6/SCD/ELOVL2	0.878475152626635
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/642	78/9376	1.31064781532071	ENO1/LSM1/LSM6/PFKL/DDX6/CNOT7/PAN3	0.746908484067558
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/642	323/9376	1.13036852714524	TPM1/CCNE1/CCND1/FSCN1/IGF2BP1/PRKCA/EFNA2/EZR/KIF23/CDCA5/EFNA1/HMGA2/MAPK1/FZD3/SOS2/HDAC2/ATM/MCL1/TRIM71/PDCD4/MAPK3/GLS/EP300/KRAS/CDC25C	0.646434190306918
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/642	29/9376	1.51079600386723	TEAD4/TEAD1/YAP1	0.74689048539531
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/642	122/9376	1.1970788008784	VAV1/PDPK1/MAPK1/SOS2/PPP2CA/PPP3CA/RELA/MAPK3/KRAS/NFATC2	0.594020779510162
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	13/642	163/9376	1.16476501729641	CCNE1/BIRC5/PRKCA/CCNA2/EGR3/MAPK1/SOS2/RELA/MAPK3/TAB2/EP300/KRAS/NFATC2	0.575313855390864
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/642	17/9376	1.71816016126077	CD209/MYH10	0.803484688657104
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/642	69/9376	1.26994446701883	CALM1/FOSB/PRKCA/HDAC2/PPP3CA/CAMK2D	0.61015570615267
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/642	56/9376	1.30396083667112	CD14/SAR1B/BNIP3/RAB1B/RELA	0.618515015076492
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/642	83/9376	1.23169312765079	AURKB/USP16/HDAC2/EP300/USP7/PHC3/MTF2	0.574805332217695
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/642	70/9376	1.25180240320427	SLC2A1/MAPK1/SOS2/MAPK3/EP300/KRAS	0.573289417446255
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/642	44/9376	1.32766921551968	DYNC1LI2/DYNC1I2/DYNC1H1/DCTN6	0.5906377119398
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/642	31/9376	1.41332529394031	GCSH/ACO2/GLDC	0.6249276431889
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/642	31/9376	1.41332529394031	HSPA5/TMEM208/BAG6	0.6249276431889
Organismal Systems	Immune system	hsa04611	Platelet activation	10/642	126/9376	1.15907629926322	ACTB/GNAI1/MAPK1/PPP1R12A/SYK/COL1A1/MAPK3/COL3A1/LYN/ROCK2	0.487378586050644
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	18/642	238/9376	1.10453153223906	CALM1/PGF/IGF1/PLA2G2A/PRKCA/RAC3/EFNA2/IGF2/EFNA1/GNG2/CSF1R/MAPK1/SOS2/RELA/MAPK3/SHOC2/FLT4/KRAS	0.442850130004785
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/642	99/9376	1.18015041379527	CCND1/IGF1/MMP2/MAPK1/SOS2/MAPK3/KRAS/SP1	0.488534953004975
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/642	155/9376	1.13066023515225	CCNE1/CCND1/CYP11A1/AHR/GNAI1/MAPK1/FZD3/HSD3B1/TCF7L2/MAPK3/CAMK2D/SP1	0.444699695403852
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/642	169/9376	1.12341241313204	HMGB1/RPS27A/UBB/EIF2AK4/PDPK1/BNIP3/MAPK1/PPP2CA/GORASP2/MAPK3/KRAS/ATG12/RRAGA	0.438924358932157
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/642	86/9376	1.18872708831413	PRKCA/CBL/MAPK1/SOS2/MAPK3/KRAS/CAMK2D	0.476674771129255
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/642	32/9376	1.36915887850467	PFKL/G6PC3/PGM2	0.567111495525406
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/642	59/9376	1.23765774328106	RRM2/TYMS/TK1/NT5C2/NT5C	0.496462540599032
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/642	59/9376	1.23765774328106	RRM2/PRDX6/GSTA4/TXNDC12/GPX8	0.496462540599032
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/642	142/9376	1.1313237681541	FOSB/FHL2/NCF4/CSF1R/MAPK1/SYK/PPP3CA/RELA/MAPK3/TAB2/NFATC2	0.42750296506281
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/642	73/9376	1.20035846882601	RAN/PIN1/MX2/NELFE/EP300/BICD2	0.465912306657024
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/642	157/9376	1.11625692005476	CX3CR1/STAB1/SLC2A1/CALR/GAS6/ARG2/MAPK1/ADAM9/UQCRFS1/MAPK3/CAMK2D/NFATC2	0.398266053293119
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/642	116/9376	1.13309700290042	PRKCA/SLC1A1/GNAI1/SLC38A1/GNG2/MAPK1/PPP3CA/MAPK3/GLS	0.391055443618823
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/642	20/9376	1.46043613707165	CYB5R1/CYB5R3	0.558837899184919
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/642	89/9376	1.14865763589905	LAMA4/HMMR/COL4A1/LAMB1/COL4A2/COL1A1/COL6A3	0.382024363608589
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/642	62/9376	1.17777107828359	IGF1/CRYAB/HDAC2/KRAS/EIF4EBP2	0.380746038219544
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/642	90/9376	1.13589477327795	BATF3/MAPK1/PPP3CA/RELA/MAPK3/KRAS/NFATC2	0.351201390654322
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	17/642	232/9376	1.07014716940595	ACTB/RAC3/EZR/DIAPH3/ENAH/C9/MYH10/VAV1/MAPK1/SOS2/PPP1R12A/NCKAP1/MAPK3/SSH2/PFN1/KRAS/ROCK2	0.29331386535081
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/642	77/9376	1.13800218473116	CCND1/RAC3/MAPK1/RELA/MAPK3/KRAS	0.329655069656134
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/642	78/9376	1.12341241313204	CAV1/ACTB/CBL/CTTN/ARHGAP10/HCLS1	0.296727592667621
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/642	78/9376	1.12341241313204	CALM1/CD14/GNAI1/MAPK1/RELA/MAPK3	0.296727592667621
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/642	78/9376	1.12341241313204	HLA-DRB5/NCF4/MAPK1/RELA/MAPK3/TAB2	0.296727592667621
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/642	50/9376	1.16834890965732	ARG2/CKMT1A/GAMT/CNDP2	0.323589307795561
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/642	36/9376	1.21703011422638	G6PC3/GPI/PGM2	0.353707582275849
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/642	36/9376	1.21703011422638	POLE4/POLE3/RPA2	0.353707582275849
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	9/642	122/9376	1.07737092079056	LEP/CCND1/IGF1/CCNA2/PDPK1/PPP2CA/PFKL/G6PC3/SCD	0.233205877418475
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/642	122/9376	1.07737092079056	IGF1/PRKCA/GNAI1/IGFBP3/MAPK1/SOS2/MAPK3/EP300/KRAS	0.233205877418475
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/642	23/9376	1.26994446701883	ARG2/GLS	0.35140621610016
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/642	23/9376	1.26994446701883	GGPS1/PMVK	0.35140621610016
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/642	52/9376	1.12341241313204	CGA/IGF1/CYP11A1/HSD3B1	0.241939033929954
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	11/642	154/9376	1.04316866933689	TPM1/CALM1/MYL4/PRKCA/GNAI1/TPM2/TPM4/MAPK1/PPP2CA/MAPK3/CAMK2D	0.146441113257685
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/642	38/9376	1.15297589768815	GPI/AMDHD2/PGM2	0.256173635919541
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/642	38/9376	1.15297589768815	NNMT/NT5C2/NT5C	0.256173635919541
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/642	140/9376	1.04316866933689	RPS6/CALM1/CCND1/MYL4/GNAI1/EGR1/GNG2/MAPK1/MAPK3/KRAS	0.139520259709539
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/642	24/9376	1.21703011422638	B3GAT3/B4GALT7	0.288615684868994
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/642	97/9376	1.05392298551562	CALM1/PRKCA/GNAI1/GNG2/MAPK1/MAPK3/CAMK2D	0.144729068751329
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/642	170/9376	1.03089609675646	CCND1/ACTB/PRKCA/IGF2/GSTA4/MAPK1/FZD3/SOS2/TCF7L2/MAPK3/KRAS/BRD7	0.110214605467755
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/642	128/9376	1.0268691588785	RRM2/PDE4C/AK1/ITPA/NT5C2/NT5C/ADK/NTPCR/PGM2	0.0829815808346825
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/642	173/9376	1.01301928583005	CCL2/HLA-DRB5/ACTB/PRKCA/ADAR/MX2/MAPK1/RAE1/RELA/MAPK3/DNAJC3/EP300	0.0468588969053625
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/642	144/9376	1.01419176185531	IGF1/LIFR/ID4/BMP4/DLX5/ID1/MAPK1/FZD3/MAPK3/KRAS	0.0465281967656881
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/642	100/9376	1.02230529595016	HLA-DRB5/GYPA/IL2RA/CD14/CSF1R/CD1C/CD1E	0.0607958840948668
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/642	115/9376	1.01595557361506	PRKCA/GNAI1/KCNQ3/GNG2/MAPK1/MAPK3/KRAS/CAMK2D	0.0466744230795941
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/642	160/9376	1.00404984423676	HLA-G/HLA-DRB5/CLDN10/CLDN4/CLDN3/CLDN6/JAM3/CNTNAP2/CLDN7/CLDN19/LRRC4	0.0140079194784187
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/642	71/9376	1.02847615286736	JAM3/CSK/ATP6V1E1/RELA/LYN	0.0652978466672162
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/642	86/9376	1.01890893284069	DSP/ACTB/DSG2/PKP2/TCF7L2/EMD	0.0477589693914531
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/642	57/9376	1.02486746461168	ELOVL6/SCD/CPT2/ELOVL2	0.0510541251916593
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/642	117/9376	0.998588811672924	ACTB/EPC1/POLE3/HDAC2/BAZ1B/DPF2/PHF6/BRD7	-0.00416430396756283
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/642	103/9376	0.992529413543841	COL4A1/SLC1A1/DPP4/COL4A2/COL1A1/COL6A3/COL3A1	-0.02066853701911
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/642	148/9376	0.986781173697062	CCND1/IGF1/MAPK1/FZD3/SOS2/TCF7L2/MAPK3/FLT4/KRAS/SP1	-0.0439457134096398
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/642	178/9376	0.984563687913473	CCND1/APCDD1/PRKCA/RAC3/FZD3/NOTUM/TCF7L2/PPP3CA/EP300/CAMK2D/ROCK2/NFATC2	-0.0563706973469288
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/642	73/9376	1.00029872402168	CCND1/IGF1/MAPK1/MAPK3/KRAS	0.000694650936442954
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/642	253/9376	0.981320724514548	ACTB/RPS27A/CD14/UBB/BNIP3/MAPK1/CTTN/CAPN1/ATM/HCLS1/RELA/MAPK3/TAB2/PFN1/ROCK2/ATG12/RRAGA	-0.0816578627419535
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/642	12/9376	1.21703011422638	COQ4	0.203951300025372
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/642	12/9376	1.21703011422638	CD209	0.203951300025372
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/642	119/9376	0.981805806434723	CCL2/BIRC2/MAPK1/RELA/MAPK3/TAB2/XIAP/ITCH	-0.0541524011249942
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/642	28/9376	1.04316866933689	ELOVL6/ELOVL2	0.0620204458712994
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/642	44/9376	0.995751911639762	HMGB1/POLE4/POLE3	-0.00765736013750829
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/642	75/9376	0.973624091381101	CGA/PRKCA/HSPA5/HSP90B1/GPX8	-0.0621755731571273
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/642	30/9376	0.973624091381101	ACO2/PDHA1	-0.0392285022440401
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/642	46/9376	0.95245835026412	ALAS2/UROS/HMOX2	-0.0876312285712632
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/642	47/9376	0.932193278981905	PDHA1/HAGH/LDHA	-0.126342854335745
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/642	63/9376	0.927261039410572	COLGALT1/ASH1L/PLOD3/NSD1	-0.157050427373497
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/642	63/9376	0.927261039410572	POLE4/POLR2E/POLE3/RPA2	-0.157050427373497
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/642	32/9376	0.912772585669782	PPP2CA/ATG12	-0.134001028478577
Human Diseases	Immune disease	hsa05310	Asthma	2/642	32/9376	0.912772585669782	FCER1A/HLA-DRB5	-0.134001028478577
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/642	15/9376	0.973624091381101	ST3GAL5	-0.0277165068623742
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/642	144/9376	0.912772585669782	CCND1/CD14/TRA2B/C3AR1/TCF7L2/RELA/SCD/TAB2/IL17RA	-0.285978184998862
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/642	144/9376	0.912772585669782	PRKCA/PSMA7/ATXN3/PSMA5/PSMD9/PSMC6/PSMD6/PSMD2/SP1	-0.285978184998862
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/642	49/9376	0.894144573717337	FOSB/GNAI1/RELA	-0.201412646263749
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/642	98/9376	0.894144573717337	CALM1/PRKCA/DGKZ/INPPL1/PPIP5K2/INPP4B	-0.285591671057719
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/642	33/9376	0.885112810346455	ACO2/PDHA1	-0.179238772036975
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/642	66/9376	0.885112810346455	HLA-DRB5/MAF/GATA3/RELA	-0.253930747826743
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/642	16/9376	0.912772585669782	MIF	-0.0946720157835839
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/642	16/9376	0.912772585669782	NAGA	-0.0946720157835839
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/642	99/9376	0.885112810346455	TPM1/IGF1/ACTB/TPM2/TPM4/EMD	-0.311553032911993
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/642	115/9376	0.888961126913179	PRKCA/GNAI1/GNG2/MAPK1/APP/MAPK3/KRAS	-0.324819117492796
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/642	34/9376	0.859080080630383	POLR2E/POLR3K	-0.223171365904733
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/642	51/9376	0.859080080630383	ENPP2/PLA2G2A/PAFAH1B1	-0.273577018538106
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/642	51/9376	0.859080080630383	ACTB/PRKCA/ATP6V1E1	-0.273577018538106
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/642	180/9376	0.892488750432676	HLA-G/CCL2/HLA-DRB5/SRSF3/CALR/BIRC2/SRSF2/SYK/RELA/TAB2/SRSF4	-0.394854633999428
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/642	133/9376	0.878457826810016	CALM1/PRKCA/GNAI1/GNG2/PPP2CA/PPP3CA/CAMK2D/ARRB1	-0.382730347509324
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/642	17/9376	0.859080080630383	MTR	-0.157662599024576
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/642	70/9376	0.834534935469515	LEP/SLC2A1/RELA/G6PC3	-0.376721465900526
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/642	18/9376	0.811353409484251	MAN2B2	-0.217190212883542
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/642	18/9376	0.811353409484251	MTR	-0.217190212883542
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/642	136/9376	0.859080080630383	CCNE1/CD209/CCND1/IL2RA/ADAR/MX2/RELA/TAB2	-0.448799550250904
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/642	54/9376	0.811353409484251	CGA/HLA-G/HLA-DRB5	-0.376910164362455
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/642	37/9376	0.789424938957649	RIMKLA/GLS	-0.347939846898743
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/642	37/9376	0.789424938957649	GPI/PGM2	-0.347939846898743
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/642	105/9376	0.834534935469515	TPM1/IGF1/ACTB/TPM2/TPM4/EMD	-0.462257781274005
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/642	72/9376	0.811353409484251	ADAR/PIN1/RELA/ATG12	-0.435639164278597
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/642	89/9376	0.820469739927894	PRKCA/GNAI1/SLC38A1/GNG2/GLS	-0.46136165786401
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/642	19/9376	0.768650598458764	HGSNAT	-0.273667625853861
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/642	90/9376	0.811353409484251	IGF1/RELA/SESN3/KRAS/EIF4E2	-0.487531222380554
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/642	56/9376	0.78237650200267	CCND1/BOC/ARRB1	-0.442831394395907
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/642	91/9376	0.802437437951457	PDE4C/PRKCA/GNAI1/GNG2/ARRB1	-0.513429655978057
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/642	39/9376	0.748941608754693	HLA-G/HLA-DRB5	-0.425941468773601
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/642	109/9376	0.803909800222927	SLC2A1/MLXIPL/PDPK1/RELA/G6PC3/RPS6KA3	-0.558272345048978
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/642	226/9376	0.840073884156259	CGA/CALM1/PDE4C/RAC3/GNAI1/VAV1/MAPK1/PPP1R12A/RELA/MAPK3/EP300/CAMK2D/ROCK2	-0.659795912257561
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/642	22/9376	0.663834607759841	CNDP2	-0.427968906869296
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/642	78/9376	0.748941608754693	ISYNA1/INPPL1/PPIP5K2/INPP4B	-0.603634190132253
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/642	43/9376	0.679272621893791	CPT2/ECI2	-0.57148677847831
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/642	23/9376	0.634972233509413	RPA2	-0.475183016753604
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/642	23/9376	0.634972233509413	LNPEP	-0.475183016753604
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/642	23/9376	0.634972233509413	GLS	-0.475183016753604
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/642	149/9376	0.784126785004913	FCER1A/PRKCA/MAPK1/DGKZ/SOS2/SYK/MAPK3/KRAS	-0.720125503445565
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/642	98/9376	0.745120478097781	CALM1/CYP11A1/PRKCA/HSD3B1/CAMK2D	-0.687649855417655
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/642	44/9376	0.663834607759841	TUSC3/STT3B	-0.605952432214816
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/642	44/9376	0.663834607759841	HLA-G/HLA-DRB5	-0.605952432214816
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/642	150/9376	0.778899273104881	CCNE1/CCND1/MAPK1/FZD3/SOS2/TCF7L2/MAPK3/KRAS	-0.740074828528698
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/642	63/9376	0.695445779557929	PLA2G2A/PTGDS/HPGD	-0.657561918554296
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/642	63/9376	0.695445779557929	BMP4/FZD3/TCF7L2	-0.657561918554296
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/642	99/9376	0.737594008622046	CALM1/IGF1/PRKCA/HRH1/CAMK2D	-0.711597025870478
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/642	99/9376	0.737594008622046	KRT19/KRT18/HLA-DRB5/KRT23/C3AR1	-0.711597025870478
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/642	82/9376	0.712407871742269	RRM2/TK1/GSTA4/ITPA	-0.709135366365568
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/642	45/9376	0.6490827275874	ABCG2/ABCD1	-0.639725210183118
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/642	45/9376	0.6490827275874	HLA-G/HLA-DRB5	-0.639725210183118
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/642	83/9376	0.70382464437188	ABCD1/PRDX5/PMVK/ECI2	-0.734778693751796
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/642	65/9376	0.674047447879224	CYP11A1/HSD3B1/SP1	-0.7149233129863
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/642	47/9376	0.621462185987937	MAPK1/MAPK3	-0.705321643315193
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/642	26/9376	0.56170620656602	PLA2G2A	-0.606726197837696
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/642	48/9376	0.608515057113188	IVD/HIBADH	-0.737204489736164
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/642	49/9376	0.596096382478225	COLGALT1/PLOD3	-0.768513238266426
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/642	69/9376	0.634972233509413	CALM1/GNAI1/PPP3CA	-0.825072568028824
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/642	88/9376	0.663834607759841	TFPI/F13A1/C9/C3AR1	-0.858973553060667
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/642	28/9376	0.521584334668447	ST3GAL6	-0.687339992903577
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/642	28/9376	0.521584334668447	ATP6V1E1	-0.687339992903577
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/642	195/9376	0.748941608754693	ACTB/HMGB1/PRKCA/NCF4/MAPK1/GSDMD/HDAC2/SYK/RELA/MAPK3	-0.960491690522793
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/642	29/9376	0.503598667955742	CALM1	-0.725842467510353
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	16/642	298/9376	0.784126785004913	LEP/CCL2/CX3CR1/CCL4L2/CXCL14/TNFRSF25/IL2RA/CCL4/CCL3L1/LIFR/BMP4/CCL4L1/CCL8/CSF1R/IL17RA/BMP7	-1.02673498582672
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/642	30/9376	0.48681204569055	GPAA1	-0.763256921614353
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/642	30/9376	0.48681204569055	PLA2G2A	-0.763256921614353
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/642	31/9376	0.471108431313436	CNDP2	-0.799658202310523
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/642	166/9376	0.70382464437188	CALM1/GNAI1/MAPK1/PPP1R12A/PPP3CA/MAPK3/ROCK2/NFATC2	-1.0438058005822
NA	NA	hsa04081	Hormone signaling	11/642	219/9376	0.733552397615898	CGA/GAST/LEP/IGF1/DIO2/IGF2/SLC40A1/GNAI1/RAMP1/GNG2/GNA15	-1.08169251714026
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/642	54/9376	0.5409022729895	UBE2T/RPA2	-0.917263329662512
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/642	168/9376	0.695445779557929	HMGB1/HSP90AB1/BIRC2/HSP90AA1/CAPN1/TRPM7/XIAP/CAMK2D	-1.07989906767006
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/642	32/9376	0.456386292834891	LDHA	-0.83511355248256
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/642	95/9376	0.614920478767011	CCL2/HLA-DRB5/CCL3L1/ATP6V1E1	-1.02273094793151
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/642	55/9376	0.531067686207873	ACER3/SGMS1	-0.945598576810484
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/642	76/9376	0.576487948844073	PDPK1/SCD/CPT2	-1.00502682391085
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/642	33/9376	0.442556405173228	GOSR1	-0.869683606309232
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/642	56/9376	0.521584334668447	TUSC3/STT3B	-0.973504599132106
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/642	191/9376	0.68816362479816	CALM1/FOSB/GNAI1/GNG2/MAPK1/SOS2/HDAC2/MAPK3/KRAS	-1.18045771607667
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/642	35/9376	0.417267467734757	PFKL	-0.936382220027396
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/642	59/9376	0.495063097312424	CGA/GNAI1	-1.05480366046402
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/642	36/9376	0.405676704742125	RPE	-0.968605931048856
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/642	37/9376	0.394712469478825	MIF	-1.00013576943425
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/642	104/9376	0.56170620656602	PLA2G2A/DGKZ/MBOAT7/SGMS1	-1.21854574458983
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/642	38/9376	0.384325299229382	RFXANK	-1.03100964938679
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/642	86/9376	0.509454466420343	SLC2A1/PRKCA/CAMK2D	-1.23898843582195
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/642	66/9376	0.442556405173228	CYP11A1/HSD3B1	-1.23209619220782
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/642	168/9376	0.608515057113188	LEP/CCND1/IL2RA/LIFR/SOS2/MCL1/EP300	-1.38814108114042
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/642	42/9376	0.347722889778964	SLC40A1	-1.148601671223
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/642	43/9376	0.339636310946896	PLA2G2A	-1.17666636228367
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/642	154/9376	0.569001092365578	ALAS2/AK1/MAT2B/UROS/COQ4/MTHFD2	-1.46207795645185
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/642	70/9376	0.417267467734757	GSTA4/SULT1A1	-1.32673234924731
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	11/642	250/9376	0.642591900311526	LAPTM4B/AP1M2/AP3B1/CLN6/ATP6V1E1/LAMTOR3/NAGA/HGSNAT/SORT1/AP1B1/RRAGA	-1.5528900989475
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/642	48/9376	0.304257528556594	G6PC3	-1.31015121518098
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/642	50/9376	0.29208722741433	HLA-DRB5	-1.36070381760665
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/642	52/9376	0.28085310328301	SORT1	-1.40982338024037
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/642	79/9376	0.369730667613076	GSTA4/AKR7A2	-1.52515809573229
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/642	79/9376	0.369730667613076	SLC1A1/ATP6V1E1	-1.52515809573229
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/642	53/9376	0.275553988126727	PRKCA	-1.43387957045331
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/642	254/9376	0.574974857114823	CALM1/PRKCA/HRH1/ASPH/PPP3CA/PHKB/FLT4/GNA15/CAMK2D/NFATC2	-1.86179990939917
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/642	90/9376	0.3245413637937	ABCG2/SLC2A1	-1.74563014193287
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/642	183/9376	0.478831520351361	RAN/UTP6/RPP30/IMP3/NOB1/EIF6	-1.93028579578392
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/642	93/9376	0.314072287542291	CALM1/PRKCA	-1.80227976545153
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/642	65/9376	0.224682482626408	DGKZ	-1.70053145628281
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/642	102/9376	0.286360026876794	PLA2G2A/PRKCA	-1.96468200217458
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/642	73/9376	0.200059744804336	GSTA4	-1.86017597194588
NA	NA	hsa04082	Neuroactive ligand signaling	5/642	199/9376	0.366943753033078	PRKCA/SLC1A1/GNAI1/HRH1/GNG2	-2.44717501255585
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/642	143/9376	0.204256802387643	HLA-DRB5/C9	-2.59965725992121
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/642	370/9376	0.276298728635177	CGA/LEP/HRH1/PGRMC1/C3AR1/KISS1/GAL	-3.85070975121859
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/642	449/9376	0.0975792519201549	CALM1/CAMK2D/ARRB1	-5.31283139282076