ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 81/1100 175/18639 0.462857142857143 7.8429038961039 1.52244528708997e-52 1.5772533174252e-49 GO:0045296 cadherin binding 51/1100 334/18639 0.152694610778443 2.58734077299946 3.85720151174927e-10 1.70106576863432e-07 GO:0019843 rRNA binding 20/1100 65/18639 0.307692307692308 5.21370629370629 4.92586612538896e-10 1.70106576863432e-07 GO:0031720 haptoglobin binding 7/1100 10/18639 0.7 11.8611818181818 2.50932548744644e-07 6.49915301248627e-05 GO:0048027 mRNA 5'-UTR binding 10/1100 24/18639 0.416666666666667 7.06022727272727 4.50919588400222e-07 9.3430538716526e-05 GO:1990948 ubiquitin ligase inhibitor activity 7/1100 11/18639 0.636363636363636 10.7828925619835 6.54730800237543e-07 0.000113050184841016 GO:0005344 oxygen carrier activity 7/1100 14/18639 0.5 8.47227272727273 5.81746787083411e-06 0.000860985244883448 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 15/1100 68/18639 0.220588235294118 3.73776737967914 7.70225377481052e-06 0.000997441863837962 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/1100 15/18639 0.466666666666667 7.90745454545455 1.03511379717822e-05 0.00119153099319626 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 8/1100 21/18639 0.380952380952381 6.45506493506493 1.46225901731981e-05 0.00151490034194332 GO:0008017 microtubule binding 35/1100 276/18639 0.126811594202899 2.14876482213439 1.63436343735906e-05 0.00153927320100363 GO:0048156 tau protein binding 11/1100 43/18639 0.255813953488372 4.3346511627907 2.87848645365449e-05 0.00248509330498838 GO:0003779 actin binding 48/1100 443/18639 0.108352144469526 1.83597783706136 3.5580929387597e-05 0.00283552637273465 GO:0009055 electron transfer activity 19/1100 116/18639 0.163793103448276 2.77539968652038 4.69492026212591e-05 0.00347424099397318 GO:0008137 NADH dehydrogenase (ubiquinone) activity 10/1100 41/18639 0.24390243902439 4.13281596452328 0.000102776223855375 0.00709841119427788 GO:0051087 protein-folding chaperone binding 20/1100 134/18639 0.149253731343284 2.52903663500678 0.000115134028931303 0.00745492837330186 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 12/1100 59/18639 0.203389830508475 3.44634822804314 0.000142415568239887 0.00867897227626607 GO:0055106 ubiquitin-protein transferase regulator activity 9/1100 36/18639 0.25 4.23613636363636 0.0001857446154757 0.0105546454048469 GO:0003954 NADH dehydrogenase activity 10/1100 44/18639 0.227272727272727 3.85103305785124 0.000193569751633292 0.0105546454048469 GO:0051082 unfolded protein binding 18/1100 121/18639 0.148760330578512 2.52067618332081 0.000258900448595507 0.0134110432372472 GO:0051787 misfolded protein binding 6/1100 17/18639 0.352941176470588 5.98042780748663 0.000293441609391874 0.0144764527299991 GO:0004601 peroxidase activity 11/1100 57/18639 0.192982456140351 3.27 0.000432436323604109 0.0203638196024481 GO:0005542 folic acid binding 5/1100 13/18639 0.384615384615385 6.51713286713287 0.000612597706170236 0.0275935314605376 GO:0015631 tubulin binding 39/1100 385/18639 0.101298701298701 1.71646044864227 0.000714330687272181 0.0308352746672492 GO:0046966 nuclear thyroid hormone receptor binding 7/1100 28/18639 0.25 4.23613636363636 0.000968340503653327 0.0385846446840326 GO:0097718 disordered domain specific binding 7/1100 28/18639 0.25 4.23613636363636 0.000968340503653327 0.0385846446840326 GO:0051219 phosphoprotein binding 14/1100 93/18639 0.150537634408602 2.5507917888563 0.00107341992990089 0.0401051364237004 GO:0004715 non-membrane spanning protein tyrosine kinase activity 9/1100 45/18639 0.2 3.38890909090909 0.00108392260604596 0.0401051364237004 GO:0019887 protein kinase regulator activity 28/1100 255/18639 0.109803921568627 1.86057754010695 0.00116454920778443 0.0416025165263681 GO:0140517 protein-RNA adaptor activity 6/1100 22/18639 0.272727272727273 4.62123966942149 0.00137187496088711 0.0455760801281587 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 17/1100 128/18639 0.1328125 2.25044744318182 0.00140705860495639 0.0455760801281587 GO:0019208 phosphatase regulator activity 16/1100 117/18639 0.136752136752137 2.3172027972028 0.00140775537075394 0.0455760801281587 GO:0044389 ubiquitin-like protein ligase binding 33/1100 322/18639 0.102484472049689 1.73655279503106 0.00145978910203362 0.0456263543464055 GO:0019888 protein phosphatase regulator activity 15/1100 107/18639 0.14018691588785 2.37540356839422 0.0015225148026045 0.0456263543464055 GO:0022853 active monoatomic ion transmembrane transporter activity 16/1100 118/18639 0.135593220338983 2.2975654853621 0.00154143089008127 0.0456263543464055 GO:0004857 enzyme inhibitor activity 40/1100 416/18639 0.0961538461538462 1.62928321678322 0.00165575099669405 0.046365268715378 GO:0019207 kinase regulator activity 30/1100 287/18639 0.104529616724739 1.77120684193855 0.00173037732521082 0.046365268715378 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/1100 48/18639 0.1875 3.17710227272727 0.00175038587992536 0.046365268715378 GO:0005159 insulin-like growth factor receptor binding 5/1100 16/18639 0.3125 5.29517045454545 0.00179209526153844 0.046365268715378 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 4/1100 10/18639 0.4 6.77781818181818 0.00190082474313986 0.046365268715378 GO:0071723 lipopeptide binding 4/1100 10/18639 0.4 6.77781818181818 0.00190082474313986 0.046365268715378 GO:0016651 oxidoreductase activity, acting on NAD(P)H 13/1100 88/18639 0.147727272727273 2.50317148760331 0.00190109051647286 0.046365268715378 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 10/1100 58/18639 0.172413793103448 2.92147335423198 0.00192442717641048 0.046365268715378 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/1100 40/18639 0.2 3.38890909090909 0.00203252749050277 0.0478567836400199 GO:0045309 protein phosphorylated amino acid binding 10/1100 59/18639 0.169491525423729 2.87195685670262 0.00219699670005541 0.0503679254331973 GO:0140033 acetylation-dependent protein binding 6/1100 24/18639 0.25 4.23613636363636 0.00223641367753579 0.0503679254331973 GO:0008307 structural constituent of muscle 8/1100 42/18639 0.19047619047619 3.22753246753247 0.00281033889956432 0.0619470446797582 GO:0070064 proline-rich region binding 5/1100 18/18639 0.277777777777778 4.70681818181818 0.0031850926735695 0.0669125546118423 GO:0098641 cadherin binding involved in cell-cell adhesion 5/1100 18/18639 0.277777777777778 4.70681818181818 0.0031850926735695 0.0669125546118423 GO:0019825 oxygen binding 7/1100 34/18639 0.205882352941176 3.48858288770053 0.00322937039632444 0.0669125546118423 GO:0050681 nuclear androgen receptor binding 6/1100 26/18639 0.230769230769231 3.91027972027972 0.00345794100748891 0.0702436643874217 GO:0031625 ubiquitin protein ligase binding 30/1100 302/18639 0.0993377483443709 1.68323299217339 0.00371631748036868 0.0740404790319607 GO:0043021 ribonucleoprotein complex binding 20/1100 177/18639 0.112994350282486 1.91463790446841 0.00400454254797336 0.0761299353369899 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 4/1100 12/18639 0.333333333333333 5.64818181818182 0.00407422539529407 0.0761299353369899 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/1100 12/18639 0.333333333333333 5.64818181818182 0.00407422539529407 0.0761299353369899 GO:0008301 DNA binding, bending 5/1100 19/18639 0.263157894736842 4.45909090909091 0.00411513163983729 0.0761299353369899 GO:0019902 phosphatase binding 21/1100 190/18639 0.110526315789474 1.87281818181818 0.00420332613212035 0.0763972960153805 GO:0038024 cargo receptor activity 10/1100 65/18639 0.153846153846154 2.60685314685315 0.00455120786431093 0.080585889639714 GO:0098632 cell-cell adhesion mediator activity 9/1100 55/18639 0.163636363636364 2.77274380165289 0.00458935085786016 0.080585889639714 GO:0098631 cell adhesion mediator activity 11/1100 76/18639 0.144736842105263 2.4525 0.00483900985732747 0.0835535702031877 GO:0001784 phosphotyrosine residue binding 8/1100 47/18639 0.170212765957447 2.88417794970986 0.00577299545790571 0.0980462835145953 GO:0051861 glycolipid binding 6/1100 29/18639 0.206896551724138 3.50576802507837 0.00613469796114033 0.101147747022286 GO:0051015 actin filament binding 22/1100 209/18639 0.105263157894737 1.78363636363636 0.00615087650811199 0.101147747022286 GO:0019838 growth factor binding 16/1100 136/18639 0.117647058823529 1.99347593582888 0.00645258289839818 0.102475414221238 GO:0051010 microtubule plus-end binding 5/1100 21/18639 0.238095238095238 4.03441558441558 0.00652835650444178 0.102475414221238 GO:0072542 protein phosphatase activator activity 5/1100 21/18639 0.238095238095238 4.03441558441558 0.00652835650444178 0.102475414221238 GO:0005178 integrin binding 18/1100 161/18639 0.111801242236025 1.89442123094297 0.00683163019639467 0.105635356469625 GO:0072341 modified amino acid binding 12/1100 91/18639 0.131868131868132 2.23444555444555 0.00711572633272874 0.108410183539808 GO:0003712 transcription coregulator activity 43/1100 495/18639 0.0868686868686869 1.47195041322314 0.00726949551283611 0.108826363511649 GO:0036002 pre-mRNA binding 9/1100 59/18639 0.152542372881356 2.58476117103236 0.00735313266970602 0.108826363511649 GO:0034236 protein kinase A catalytic subunit binding 4/1100 14/18639 0.285714285714286 4.8412987012987 0.00749509015411538 0.10936497746005 GO:0097110 scaffold protein binding 10/1100 70/18639 0.142857142857143 2.42064935064935 0.00774105165154904 0.111385132097289 GO:0004713 protein tyrosine kinase activity 16/1100 140/18639 0.114285714285714 1.93651948051948 0.0084763794821184 0.120294919773625 GO:0140297 DNA-binding transcription factor binding 42/1100 488/18639 0.0860655737704918 1.45834202682563 0.00921546518080868 0.126221619075008 GO:0015399 primary active transmembrane transporter activity 18/1100 166/18639 0.108433734939759 1.83736035049288 0.00928550997052238 0.126221619075008 GO:0003713 transcription coactivator activity 25/1100 256/18639 0.09765625 1.65474076704545 0.00937776972941983 0.126221619075008 GO:0008135 translation factor activity, RNA binding 11/1100 83/18639 0.132530120481928 2.24566265060241 0.00939365020164964 0.126221619075008 GO:0003743 translation initiation factor activity 8/1100 51/18639 0.156862745098039 2.6579679144385 0.00950317209251992 0.126221619075008 GO:0070577 lysine-acetylated histone binding 5/1100 23/18639 0.217391304347826 3.68359683794466 0.00978958011329294 0.12837981009331 GO:0180051 translation factor activity 11/1100 84/18639 0.130952380952381 2.21892857142857 0.0102498884954865 0.132369629319491 GO:0043539 protein serine/threonine kinase activator activity 10/1100 73/18639 0.136986301369863 2.32117061021171 0.0103493629101147 0.132369629319491 GO:0016860 intramolecular oxidoreductase activity 8/1100 53/18639 0.150943396226415 2.55766723842196 0.0119300909160788 0.149423583532116 GO:0003697 single-stranded DNA binding 14/1100 121/18639 0.115702479338843 1.96052592036063 0.0119711944335576 0.149423583532116 GO:0016209 antioxidant activity 11/1100 86/18639 0.127906976744186 2.16732558139535 0.0121408213248248 0.149736796339506 GO:0044183 protein folding chaperone 10/1100 75/18639 0.133333333333333 2.25927272727273 0.0124272926681281 0.151466767108008 GO:0140463 chromatin-protein adaptor activity 8/1100 54/18639 0.148148148148148 2.51030303030303 0.0133013230308006 0.160234542557087 GO:0035173 histone kinase activity 32/1100 360/18639 0.0888888888888889 1.50618181818182 0.0138285108726061 0.161410635415151 GO:0140030 modification-dependent protein binding 18/1100 173/18639 0.104046242774566 1.76301629006831 0.0138545749530671 0.161410635415151 GO:0019211 phosphatase activator activity 5/1100 25/18639 0.2 3.38890909090909 0.0140221594472621 0.161410635415151 GO:0042974 nuclear retinoic acid receptor binding 5/1100 25/18639 0.2 3.38890909090909 0.0140221594472621 0.161410635415151 GO:0046965 nuclear retinoid X receptor binding 4/1100 17/18639 0.235294117647059 3.98695187165775 0.0154750145243508 0.176177088431071 GO:0042826 histone deacetylase binding 14/1100 127/18639 0.110236220472441 1.86790264853257 0.0177288884676667 0.194766242071057 GO:0005522 profilin binding 3/1100 10/18639 0.3 5.08336363636364 0.0179891304636499 0.194766242071057 GO:0098505 G-rich strand telomeric DNA binding 3/1100 10/18639 0.3 5.08336363636364 0.0179891304636499 0.194766242071057 GO:0035401 histone H3Y41 kinase activity 13/1100 115/18639 0.11304347826087 1.91547035573123 0.0180478371031095 0.194766242071057 GO:0140801 histone H2AXY142 kinase activity 13/1100 115/18639 0.11304347826087 1.91547035573123 0.0180478371031095 0.194766242071057 GO:0048306 calcium-dependent protein binding 10/1100 80/18639 0.125 2.11806818181818 0.0189843249928523 0.198998278607159 GO:0000400 four-way junction DNA binding 4/1100 18/18639 0.222222222222222 3.76545454545455 0.0189864207674312 0.198998278607159 GO:0140996 histone H3 kinase activity 31/1100 357/18639 0.0868347338935574 1.47137509549274 0.0204557929063419 0.198998278607159 GO:0033192 calmodulin-dependent protein phosphatase activity 10/1100 81/18639 0.123456790123457 2.09191919191919 0.020552911014446 0.198998278607159 GO:0140791 histone H2AXS140 phosphatase activity 10/1100 81/18639 0.123456790123457 2.09191919191919 0.020552911014446 0.198998278607159 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 10/1100 81/18639 0.123456790123457 2.09191919191919 0.020552911014446 0.198998278607159 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 10/1100 81/18639 0.123456790123457 2.09191919191919 0.020552911014446 0.198998278607159 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 10/1100 81/18639 0.123456790123457 2.09191919191919 0.020552911014446 0.198998278607159 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 10/1100 81/18639 0.123456790123457 2.09191919191919 0.020552911014446 0.198998278607159 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 10/1100 81/18639 0.123456790123457 2.09191919191919 0.020552911014446 0.198998278607159 GO:1990439 MAP kinase serine/threonine phosphatase activity 10/1100 81/18639 0.123456790123457 2.09191919191919 0.020552911014446 0.198998278607159 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 10/1100 82/18639 0.121951219512195 2.06640798226164 0.0222139234189803 0.211134171211592 GO:0033549 MAP kinase phosphatase activity 10/1100 82/18639 0.121951219512195 2.06640798226164 0.0222139234189803 0.211134171211592 GO:0046875 ephrin receptor binding 5/1100 28/18639 0.178571428571429 3.02581168831169 0.0224262613571336 0.21121460696355 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/1100 11/18639 0.272727272727273 4.62123966942149 0.0236669750049293 0.21137056987161 GO:0032794 GTPase activating protein binding 3/1100 11/18639 0.272727272727273 4.62123966942149 0.0236669750049293 0.21137056987161 GO:0043522 leucine zipper domain binding 3/1100 11/18639 0.272727272727273 4.62123966942149 0.0236669750049293 0.21137056987161 GO:0048407 platelet-derived growth factor binding 3/1100 11/18639 0.272727272727273 4.62123966942149 0.0236669750049293 0.21137056987161 GO:0050786 RAGE receptor binding 3/1100 11/18639 0.272727272727273 4.62123966942149 0.0236669750049293 0.21137056987161 GO:0140031 phosphorylation-dependent protein binding 3/1100 11/18639 0.272727272727273 4.62123966942149 0.0236669750049293 0.21137056987161 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 10/1100 83/18639 0.120481927710843 2.04151150054764 0.0239701252295735 0.212248288357591 GO:0000217 DNA secondary structure binding 6/1100 39/18639 0.153846153846154 2.60685314685315 0.0255911666680046 0.221106470087689 GO:0003785 actin monomer binding 5/1100 29/18639 0.172413793103448 2.92147335423198 0.0258203370646322 0.221106470087689 GO:0004860 protein kinase inhibitor activity 10/1100 84/18639 0.119047619047619 2.01720779220779 0.0258242112747204 0.221106470087689 GO:0017018 myosin phosphatase activity 10/1100 84/18639 0.119047619047619 2.01720779220779 0.0258242112747204 0.221106470087689 GO:0000339 RNA cap binding 4/1100 20/18639 0.2 3.38890909090909 0.0273841466890745 0.228790128789364 GO:0015095 magnesium ion transmembrane transporter activity 4/1100 20/18639 0.2 3.38890909090909 0.0273841466890745 0.228790128789364 GO:0043024 ribosomal small subunit binding 4/1100 20/18639 0.2 3.38890909090909 0.0273841466890745 0.228790128789364 GO:0140662 ATP-dependent protein folding chaperone 6/1100 40/18639 0.15 2.54168181818182 0.028654611232807 0.237489417897505 GO:0001968 fibronectin binding 5/1100 30/18639 0.166666666666667 2.82409090909091 0.0295258069077022 0.238816913259293 GO:0141003 histone H2AX kinase activity 30/1100 354/18639 0.0847457627118644 1.43597842835131 0.0297592834029755 0.238816913259293 GO:0016423 tRNA (guanine) methyltransferase activity 3/1100 12/18639 0.25 4.23613636363636 0.0301978915414743 0.238816913259293 GO:0035497 cAMP response element binding 3/1100 12/18639 0.25 4.23613636363636 0.0301978915414743 0.238816913259293 GO:0043047 single-stranded telomeric DNA binding 3/1100 12/18639 0.25 4.23613636363636 0.0301978915414743 0.238816913259293 GO:0097371 MDM2/MDM4 family protein binding 3/1100 12/18639 0.25 4.23613636363636 0.0301978915414743 0.238816913259293 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/1100 41/18639 0.146341463414634 2.47968957871397 0.0319497559552955 0.249928936333142 GO:0070182 DNA polymerase binding 4/1100 21/18639 0.19047619047619 3.22753246753247 0.0322913914383998 0.249928936333142 GO:0005200 structural constituent of cytoskeleton 12/1100 112/18639 0.107142857142857 1.81548701298701 0.0325679598503611 0.249928936333142 GO:0043022 ribosome binding 12/1100 112/18639 0.107142857142857 1.81548701298701 0.0325679598503611 0.249928936333142 GO:0003714 transcription corepressor activity 19/1100 204/18639 0.0931372549019608 1.57816844919786 0.0330329353401414 0.251633242738136 GO:0042056 chemoattractant activity 6/1100 42/18639 0.142857142857143 2.42064935064935 0.0354818065075053 0.268314974757485 GO:0004674 protein serine/threonine kinase activity 35/1100 433/18639 0.0808314087759815 1.36965148015956 0.0369678694872008 0.270553209939526 GO:0106310 protein serine kinase activity 30/1100 361/18639 0.0831024930747922 1.40813397129187 0.0372017320849909 0.270553209939526 GO:0031994 insulin-like growth factor I binding 3/1100 13/18639 0.230769230769231 3.91027972027972 0.0375734410267786 0.270553209939526 GO:0035325 Toll-like receptor binding 3/1100 13/18639 0.230769230769231 3.91027972027972 0.0375734410267786 0.270553209939526 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 3/1100 13/18639 0.230769230769231 3.91027972027972 0.0375734410267786 0.270553209939526 GO:0097157 pre-mRNA intronic binding 3/1100 13/18639 0.230769230769231 3.91027972027972 0.0375734410267786 0.270553209939526 GO:0016853 isomerase activity 17/1100 180/18639 0.0944444444444444 1.60031818181818 0.037605851574606 0.270553209939526 GO:0051059 NF-kappaB binding 5/1100 32/18639 0.15625 2.64758522727273 0.0378979931754126 0.270774627101569 GO:0019210 kinase inhibitor activity 10/1100 90/18639 0.111111111111111 1.88272727272727 0.039144767952023 0.277766983549971 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 29/1100 349/18639 0.0830945558739255 1.407999479031 0.0400057466354346 0.281945262002111 GO:0001223 transcription coactivator binding 6/1100 44/18639 0.136363636363636 2.31061983471074 0.0432741104631594 0.300792546501405 GO:0017134 fibroblast growth factor binding 4/1100 23/18639 0.173913043478261 2.94687747035573 0.0435510443776165 0.300792546501405 GO:0043274 phospholipase binding 4/1100 23/18639 0.173913043478261 2.94687747035573 0.0435510443776165 0.300792546501405 GO:0000049 tRNA binding 9/1100 80/18639 0.1125 1.90626136363636 0.0456675403684311 0.312003856730506 GO:0098847 sequence-specific single stranded DNA binding 3/1100 14/18639 0.214285714285714 3.63097402597403 0.045776627628414 0.312003856730506 GO:0015078 proton transmembrane transporter activity 17/1100 185/18639 0.0918918918918919 1.55706633906634 0.04674974055443 0.31655379878686 GO:0008009 chemokine activity 6/1100 45/18639 0.133333333333333 2.25927272727273 0.0475413972533508 0.319823945158905 GO:0005540 hyaluronic acid binding 4/1100 24/18639 0.166666666666667 2.82409090909091 0.0499058021549151 0.331425711746744 GO:0070840 dynein complex binding 4/1100 24/18639 0.166666666666667 2.82409090909091 0.0499058021549151 0.331425711746744 GO:0030695 GTPase regulator activity 38/1100 489/18639 0.0777096114519427 1.31675404350251 0.0507046138270544 0.334585859393811 GO:0060589 nucleoside-triphosphatase regulator activity 38/1100 490/18639 0.0775510204081633 1.3140667903525 0.051977034996575 0.337830490481331 GO:0061631 ubiquitin conjugating enzyme activity 5/1100 35/18639 0.142857142857143 2.42064935064935 0.0529263838524371 0.337830490481331 GO:0000774 adenyl-nucleotide exchange factor activity 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0004129 cytochrome-c oxidase activity 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0031386 protein tag activity 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0033130 acetylcholine receptor binding 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0045504 dynein heavy chain binding 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0061578 K63-linked deubiquitinase activity 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0120283 protein serine/threonine kinase binding 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0141047 molecular tag activity 3/1100 15/18639 0.2 3.38890909090909 0.0547833227807564 0.337830490481331 GO:0043495 protein-membrane adaptor activity 6/1100 47/18639 0.127659574468085 2.1631334622824 0.0568306170514551 0.348381770800636 GO:0044325 transmembrane transporter binding 13/1100 136/18639 0.0955882352941176 1.61969919786096 0.0585409583670595 0.35466919806008 GO:0140789 histone phosphatase activity 13/1100 136/18639 0.0955882352941176 1.61969919786096 0.0585409583670595 0.35466919806008 GO:0051117 ATPase binding 9/1100 84/18639 0.107142857142857 1.81548701298701 0.0590665635312825 0.355656945505777 GO:0033218 amide binding 21/1100 247/18639 0.0850202429149798 1.44062937062937 0.0593905903209453 0.355656945505777 GO:0042379 chemokine receptor binding 8/1100 72/18639 0.111111111111111 1.88272727272727 0.0610952478000645 0.363223445729765 GO:0016922 nuclear receptor binding 13/1100 137/18639 0.0948905109489051 1.60787657597877 0.0613553117786765 0.363223445729765 GO:0140693 molecular condensate scaffold activity 6/1100 48/18639 0.125 2.11806818181818 0.0618554101243178 0.364103436868144 GO:0003688 DNA replication origin binding 3/1100 16/18639 0.1875 3.17710227272727 0.0645635285905741 0.371598975665749 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/1100 16/18639 0.1875 3.17710227272727 0.0645635285905741 0.371598975665749 GO:0030275 LRR domain binding 3/1100 16/18639 0.1875 3.17710227272727 0.0645635285905741 0.371598975665749 GO:0043023 ribosomal large subunit binding 3/1100 16/18639 0.1875 3.17710227272727 0.0645635285905741 0.371598975665749 GO:0046906 tetrapyrrole binding 14/1100 152/18639 0.0921052631578947 1.56068181818182 0.0655241242273494 0.375044158560961 GO:0003774 cytoskeletal motor activity 14/1100 153/18639 0.0915032679738562 1.55048128342246 0.0684044846496198 0.389379374159374 GO:0043130 ubiquitin binding 10/1100 100/18639 0.1 1.69445454545455 0.070629935445066 0.397929544442842 GO:0042162 telomeric DNA binding 5/1100 38/18639 0.131578947368421 2.22954545454545 0.0709564012489923 0.397929544442842 GO:0005044 scavenger receptor activity 4/1100 27/18639 0.148148148148148 2.51030303030303 0.0718270509756867 0.397929544442842 GO:0005385 zinc ion transmembrane transporter activity 4/1100 27/18639 0.148148148148148 2.51030303030303 0.0718270509756867 0.397929544442842 GO:0023026 MHC class II protein complex binding 4/1100 27/18639 0.148148148148148 2.51030303030303 0.0718270509756867 0.397929544442842 GO:0020037 heme binding 13/1100 142/18639 0.0915492957746479 1.55126120358515 0.0767747831950036 0.422948637401713 GO:0001221 transcription coregulator binding 11/1100 115/18639 0.0956521739130435 1.62078260869565 0.0771595487151773 0.422948637401713 GO:0004722 protein serine/threonine phosphatase activity 10/1100 103/18639 0.0970873786407767 1.64510150044131 0.0825089922979194 0.449891136950761 GO:0019903 protein phosphatase binding 13/1100 144/18639 0.0902777777777778 1.52971590909091 0.0835818228385518 0.453354808694972 GO:0003924 GTPase activity 26/1100 331/18639 0.0785498489425982 1.33099148585553 0.0842111386614005 0.453534320551579 GO:0005080 protein kinase C binding 6/1100 52/18639 0.115384615384615 1.95513986013986 0.0844904670525626 0.453534320551579 GO:0000900 mRNA regulatory element binding translation repressor activity 3/1100 18/18639 0.166666666666667 2.82409090909091 0.0863017109150886 0.458505500041189 GO:0070628 proteasome binding 3/1100 18/18639 0.166666666666667 2.82409090909091 0.0863017109150886 0.458505500041189 GO:0004864 protein phosphatase inhibitor activity 6/1100 53/18639 0.113207547169811 1.91825042881647 0.0907768275710991 0.477384737886592 GO:0051018 protein kinase A binding 6/1100 53/18639 0.113207547169811 1.91825042881647 0.0907768275710991 0.477384737886592 GO:0042169 SH2 domain binding 5/1100 41/18639 0.121951219512195 2.06640798226164 0.0919397798548375 0.48105864610915 GO:0046332 SMAD binding 8/1100 79/18639 0.10126582278481 1.71590333716916 0.0936863322139608 0.487733870219414 GO:0003925 G protein activity 6/1100 54/18639 0.111111111111111 1.88272727272727 0.0973094484103539 0.496804694998847 GO:0051287 NAD binding 6/1100 54/18639 0.111111111111111 1.88272727272727 0.0973094484103539 0.496804694998847 GO:0035925 mRNA 3'-UTR AU-rich region binding 4/1100 30/18639 0.133333333333333 2.25927272727273 0.0978486580077099 0.496804694998847 GO:0005520 insulin-like growth factor binding 3/1100 19/18639 0.157894736842105 2.67545454545455 0.0981797633613946 0.496804694998847 GO:1990380 K48-linked deubiquitinase activity 3/1100 19/18639 0.157894736842105 2.67545454545455 0.0981797633613946 0.496804694998847 GO:0019209 kinase activator activity 13/1100 148/18639 0.0878378378378378 1.48837223587224 0.0983059483347139 0.496804694998847 GO:0035198 miRNA binding 5/1100 42/18639 0.119047619047619 2.01720779220779 0.099569235712585 0.500746253389505 GO:0140104 molecular carrier activity 20/1100 249/18639 0.0803212851405622 1.36100766703176 0.100295724759771 0.50196314420832 GO:0140313 molecular sequestering activity 6/1100 55/18639 0.109090909090909 1.84849586776859 0.104084883767338 0.518122706865712 GO:0001618 virus receptor activity 8/1100 81/18639 0.0987654320987654 1.67353535353535 0.1045247545704 0.518122706865712 GO:0003777 microtubule motor activity 7/1100 68/18639 0.102941176470588 1.74429144385027 0.105255474028962 0.519260338542879 GO:0140272 exogenous protein binding 8/1100 82/18639 0.0975609756097561 1.65312638580931 0.110193868429445 0.535912757593361 GO:0019212 phosphatase inhibitor activity 6/1100 56/18639 0.107142857142857 1.81548701298701 0.111099121866403 0.535912757593361 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:0016783 sulfurtransferase activity 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:0030957 Tat protein binding 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:0042975 peroxisome proliferator activated receptor binding 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:0050815 phosphoserine residue binding 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:1905394 retromer complex binding 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:1990757 ubiquitin ligase activator activity 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:1990763 arrestin family protein binding 2/1100 10/18639 0.2 3.38890909090909 0.114321157749163 0.535912757593361 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/1100 44/18639 0.113636363636364 1.92551652892562 0.115740044585176 0.540120208064153 GO:0030295 protein kinase activator activity 12/1100 139/18639 0.0863309352517986 1.46283845650752 0.119679421903469 0.555999466780242 GO:0005096 GTPase activator activity 21/1100 271/18639 0.0774907749077491 1.3130459577323 0.122982154576721 0.568792464917336 GO:0008373 sialyltransferase activity 3/1100 21/18639 0.142857142857143 2.42064935064935 0.123736726820312 0.569638986812891 GO:0046915 transition metal ion transmembrane transporter activity 5/1100 45/18639 0.111111111111111 1.88272727272727 0.124264875501654 0.569638986812891 GO:0061980 regulatory RNA binding 6/1100 58/18639 0.103448275862069 1.75288401253918 0.125825288309943 0.5742510955467 GO:0071889 14-3-3 protein binding 4/1100 33/18639 0.121212121212121 2.05388429752066 0.127606474839592 0.577436028089367 GO:0005525 GTP binding 28/1100 378/18639 0.0740740740740741 1.25515151515151 0.127637886517823 0.577436028089367 GO:0030291 protein serine/threonine kinase inhibitor activity 5/1100 46/18639 0.108695652173913 1.84179841897233 0.133070392006237 0.58044719513854 GO:0001786 phosphatidylserine binding 6/1100 59/18639 0.101694915254237 1.72317411402157 0.133526606324483 0.58044719513854 GO:0002162 dystroglycan binding 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0005225 volume-sensitive anion channel activity 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0010854 adenylate cyclase regulator activity 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0019206 nucleoside kinase activity 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0045294 alpha-catenin binding 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0050998 nitric-oxide synthase binding 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1100 11/18639 0.181818181818182 3.08082644628099 0.134466531692326 0.58044719513854 GO:0008093 cytoskeletal anchor activity 3/1100 22/18639 0.136363636363636 2.31061983471074 0.137324712311658 0.590325319314845 GO:0015035 protein-disulfide reductase activity 4/1100 34/18639 0.117647058823529 1.99347593582888 0.138276165273322 0.591959120756867 GO:0017124 SH3 domain binding 10/1100 115/18639 0.0869565217391304 1.47343873517787 0.141426385158316 0.602953642074138 GO:0035403 histone H3T6 kinase activity 19/1100 247/18639 0.0769230769230769 1.30342657342657 0.143701814788136 0.610143770985691 GO:0140566 histone reader activity 4/1100 35/18639 0.114285714285714 1.93651948051948 0.149289040295372 0.626115910787962 GO:0031072 heat shock protein binding 11/1100 131/18639 0.083969465648855 1.42282442748092 0.151145578084608 0.626115910787962 GO:0005158 insulin receptor binding 3/1100 23/18639 0.130434782608696 2.2101581027668 0.151390762501764 0.626115910787962 GO:0000340 RNA 7-methylguanosine cap binding 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0004859 phospholipase inhibitor activity 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0005049 nuclear export signal receptor activity 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0005095 GTPase inhibitor activity 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0015132 prostaglandin transmembrane transporter activity 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0017166 vinculin binding 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0034452 dynactin binding 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0035259 nuclear glucocorticoid receptor binding 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0042301 phosphate ion binding 2/1100 12/18639 0.166666666666667 2.82409090909091 0.155320259722496 0.626115910787962 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/1100 36/18639 0.111111111111111 1.88272727272727 0.16062475700282 0.644989334321401 GO:0035035 histone acetyltransferase binding 3/1100 24/18639 0.125 2.11806818181818 0.165888613979885 0.658600748245616 GO:0050699 WW domain binding 3/1100 24/18639 0.125 2.11806818181818 0.165888613979885 0.658600748245616 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 20/1100 268/18639 0.0746268656716418 1.26451831750339 0.166944614335532 0.658600748245616 GO:0048020 CCR chemokine receptor binding 5/1100 50/18639 0.1 1.69445454545455 0.170890043043056 0.658600748245616 GO:0032182 ubiquitin-like protein binding 10/1100 120/18639 0.0833333333333333 1.41204545454545 0.171096494566306 0.658600748245616 GO:0023023 MHC protein complex binding 4/1100 37/18639 0.108108108108108 1.83184275184275 0.172262433764474 0.658600748245616 GO:0042805 actinin binding 4/1100 37/18639 0.108108108108108 1.83184275184275 0.172262433764474 0.658600748245616 GO:0002161 aminoacyl-tRNA editing activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0004535 poly(A)-specific ribonuclease activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0008253 5'-nucleotidase activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0017154 semaphorin receptor activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0019855 calcium channel inhibitor activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0031432 titin binding 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0046975 histone H3K36 methyltransferase activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0061459 L-arginine transmembrane transporter activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0070700 BMP receptor binding 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0071714 icosanoid transmembrane transporter activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0071837 HMG box domain binding 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0140666 annealing activity 2/1100 13/18639 0.153846153846154 2.60685314685315 0.176728772212627 0.658600748245616 GO:0002020 protease binding 11/1100 136/18639 0.0808823529411765 1.37051470588235 0.1798813088873 0.667946365617359 GO:0030544 Hsp70 protein binding 5/1100 51/18639 0.0980392156862745 1.66122994652406 0.180937523586243 0.668883495788856 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 18/1100 243/18639 0.0740740740740741 1.25515151515151 0.190338220014673 0.668883495788856 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1100 26/18639 0.115384615384615 1.95513986013986 0.195997008959482 0.668883495788856 GO:0008143 poly(A) binding 3/1100 26/18639 0.115384615384615 1.95513986013986 0.195997008959482 0.668883495788856 GO:0034237 protein kinase A regulatory subunit binding 3/1100 26/18639 0.115384615384615 1.95513986013986 0.195997008959482 0.668883495788856 GO:0050750 low-density lipoprotein particle receptor binding 3/1100 26/18639 0.115384615384615 1.95513986013986 0.195997008959482 0.668883495788856 GO:0004705 JUN kinase activity 2/1100 14/18639 0.142857142857143 2.42064935064935 0.198554129643329 0.668883495788856 GO:0046030 inositol trisphosphate phosphatase activity 2/1100 14/18639 0.142857142857143 2.42064935064935 0.198554129643329 0.668883495788856 GO:0070742 C2H2 zinc finger domain binding 2/1100 14/18639 0.142857142857143 2.42064935064935 0.198554129643329 0.668883495788856 GO:1990825 sequence-specific mRNA binding 2/1100 14/18639 0.142857142857143 2.42064935064935 0.198554129643329 0.668883495788856 GO:0005506 iron ion binding 12/1100 154/18639 0.0779220779220779 1.32035419126328 0.198994890850609 0.668883495788856 GO:0019001 guanyl nucleotide binding 28/1100 400/18639 0.07 1.18611818181818 0.199102614097942 0.668883495788856 GO:0032561 guanyl ribonucleotide binding 28/1100 400/18639 0.07 1.18611818181818 0.199102614097942 0.668883495788856 GO:0004676 3-phosphoinositide-dependent protein kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0004711 ribosomal protein S6 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0035175 histone H3S10 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0035979 histone H2AXS139 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0044022 histone H3S28 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0044023 histone H4S1 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0044024 histone H2AS1 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0044025 histone H2BS14 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0072354 histone H3T3 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0072371 histone H2AS121 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0072518 Rho-dependent protein serine/threonine kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0140823 histone H2BS36 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0140855 histone H3S57 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0140995 histone H2A kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0140997 histone H4 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0140998 histone H2B kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:1990244 histone H2AT120 kinase activity 18/1100 245/18639 0.073469387755102 1.24490538033395 0.199603487194182 0.668883495788856 GO:0046982 protein heterodimerization activity 26/1100 369/18639 0.0704607046070461 1.19392461197339 0.200148536384696 0.668883495788856 GO:0005085 guanyl-nucleotide exchange factor activity 17/1100 230/18639 0.0739130434782609 1.25242292490119 0.201056483480639 0.669757289022323 GO:0004677 DNA-dependent protein kinase activity 18/1100 246/18639 0.0731707317073171 1.23984478935698 0.204315876941518 0.676265969685025 GO:0140857 histone H3T45 kinase activity 18/1100 246/18639 0.0731707317073171 1.23984478935698 0.204315876941518 0.676265969685025 GO:0004177 aminopeptidase activity 4/1100 40/18639 0.1 1.69445454545455 0.208773208321288 0.681019086492533 GO:0015036 disulfide oxidoreductase activity 4/1100 40/18639 0.1 1.69445454545455 0.208773208321288 0.681019086492533 GO:0030331 nuclear estrogen receptor binding 4/1100 40/18639 0.1 1.69445454545455 0.208773208321288 0.681019086492533 GO:0035402 histone H3T11 kinase activity 18/1100 247/18639 0.0728744939271255 1.23482517482517 0.20908030104091 0.681019086492533 GO:0042393 histone binding 18/1100 247/18639 0.0728744939271255 1.23482517482517 0.20908030104091 0.681019086492533 GO:0001217 DNA-binding transcription repressor activity 20/1100 278/18639 0.0719424460431655 1.2190320470896 0.209696031458608 0.681019086492533 GO:0004679 AMP-activated protein kinase activity 18/1100 248/18639 0.0725806451612903 1.22984604105572 0.213895870368463 0.692487880317899 GO:0031406 carboxylic acid binding 14/1100 187/18639 0.0748663101604278 1.26857559552747 0.215426181523074 0.695269545351728 GO:0008201 heparin binding 13/1100 172/18639 0.0755813953488372 1.28069238900634 0.216483982964586 0.69622747119962 GO:0019783 ubiquitin-like protein peptidase activity 10/1100 127/18639 0.078740157480315 1.33421617752326 0.217067059070924 0.69622747119962 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1100 15/18639 0.133333333333333 2.25927272727273 0.220672715314494 0.701450727244945 GO:0008252 nucleotidase activity 2/1100 15/18639 0.133333333333333 2.25927272727273 0.220672715314494 0.701450727244945 GO:0004725 protein tyrosine phosphatase activity 8/1100 98/18639 0.0816326530612245 1.38322820037106 0.221346277838054 0.701450727244945 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/1100 41/18639 0.0975609756097561 1.65312638580931 0.22140384923658 0.701450727244945 GO:0043177 organic acid binding 14/1100 189/18639 0.0740740740740741 1.25515151515151 0.226791989969188 0.716330797585607 GO:0019894 kinesin binding 4/1100 42/18639 0.0952380952380952 1.61376623376623 0.234228545397001 0.732669468662064 GO:0051879 Hsp90 protein binding 4/1100 42/18639 0.0952380952380952 1.61376623376623 0.234228545397001 0.732669468662064 GO:0004721 phosphoprotein phosphatase activity 13/1100 175/18639 0.0742857142857143 1.25873766233766 0.234436460765206 0.732669468662064 GO:0101005 deubiquitinase activity 9/1100 115/18639 0.0782608695652174 1.32609486166008 0.238310672254254 0.732669468662064 GO:0000062 fatty-acyl-CoA binding 2/1100 16/18639 0.125 2.11806818181818 0.242974027703625 0.732669468662064 GO:0004707 MAP kinase activity 2/1100 16/18639 0.125 2.11806818181818 0.242974027703625 0.732669468662064 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/1100 16/18639 0.125 2.11806818181818 0.242974027703625 0.732669468662064 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1100 16/18639 0.125 2.11806818181818 0.242974027703625 0.732669468662064 GO:0055102 lipase inhibitor activity 2/1100 16/18639 0.125 2.11806818181818 0.242974027703625 0.732669468662064 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/1100 16/18639 0.125 2.11806818181818 0.242974027703625 0.732669468662064 GO:0097027 ubiquitin-protein transferase activator activity 2/1100 16/18639 0.125 2.11806818181818 0.242974027703625 0.732669468662064 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/1100 29/18639 0.103448275862069 1.75288401253918 0.243280209671573 0.732669468662064 GO:0035250 UDP-galactosyltransferase activity 3/1100 29/18639 0.103448275862069 1.75288401253918 0.243280209671573 0.732669468662064 GO:0043236 laminin binding 3/1100 29/18639 0.103448275862069 1.75288401253918 0.243280209671573 0.732669468662064 GO:0097472 cyclin-dependent protein kinase activity 3/1100 29/18639 0.103448275862069 1.75288401253918 0.243280209671573 0.732669468662064 GO:0106222 lncRNA binding 3/1100 29/18639 0.103448275862069 1.75288401253918 0.243280209671573 0.732669468662064 GO:0016504 peptidase activator activity 5/1100 57/18639 0.087719298245614 1.48636363636364 0.245242766998234 0.736439149594698 GO:0008200 ion channel inhibitor activity 4/1100 43/18639 0.0930232558139535 1.57623678646934 0.247225803453715 0.740248359474128 GO:0016248 channel inhibitor activity 4/1100 44/18639 0.0909090909090909 1.5404132231405 0.260374379340569 0.77006305218136 GO:0019205 nucleobase-containing compound kinase activity 4/1100 44/18639 0.0909090909090909 1.5404132231405 0.260374379340569 0.77006305218136 GO:0016791 phosphatase activity 19/1100 273/18639 0.0695970695970696 1.17929070929071 0.260799218281317 0.77006305218136 GO:0061134 peptidase regulator activity 16/1100 226/18639 0.0707964601769911 1.19961383748994 0.261225214493508 0.77006305218136 GO:0005539 glycosaminoglycan binding 17/1100 242/18639 0.0702479338842975 1.19031930879038 0.263099362153689 0.77006305218136 GO:0005092 GDP-dissociation inhibitor activity 2/1100 17/18639 0.117647058823529 1.99347593582888 0.265359565278712 0.77006305218136 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1100 17/18639 0.117647058823529 1.99347593582888 0.265359565278712 0.77006305218136 GO:0030169 low-density lipoprotein particle binding 2/1100 17/18639 0.117647058823529 1.99347593582888 0.265359565278712 0.77006305218136 GO:0030548 acetylcholine receptor regulator activity 2/1100 17/18639 0.117647058823529 1.99347593582888 0.265359565278712 0.77006305218136 GO:1901567 fatty acid derivative binding 2/1100 17/18639 0.117647058823529 1.99347593582888 0.265359565278712 0.77006305218136 GO:1990226 histone methyltransferase binding 2/1100 17/18639 0.117647058823529 1.99347593582888 0.265359565278712 0.77006305218136 GO:0031593 polyubiquitin modification-dependent protein binding 5/1100 59/18639 0.0847457627118644 1.43597842835131 0.267895785443933 0.773092015932911 GO:0070063 RNA polymerase binding 5/1100 59/18639 0.0847457627118644 1.43597842835131 0.267895785443933 0.773092015932911 GO:0048029 monosaccharide binding 6/1100 74/18639 0.0810810810810811 1.37388206388206 0.270988357035981 0.777580031289892 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 7/1100 89/18639 0.0786516853932584 1.33271705822268 0.271702675026005 0.777580031289892 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 7/1100 89/18639 0.0786516853932584 1.33271705822268 0.271702675026005 0.777580031289892 GO:0141110 transporter inhibitor activity 4/1100 45/18639 0.0888888888888889 1.50618181818182 0.273653355324853 0.781005168365145 GO:0070325 lipoprotein particle receptor binding 3/1100 31/18639 0.0967741935483871 1.63979472140762 0.275731933585605 0.784775503282107 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/1100 60/18639 0.0833333333333333 1.41204545454545 0.279391260034909 0.788119417370383 GO:0140793 histone H2AXY142 phosphatase activity 7/1100 90/18639 0.0777777777777778 1.31790909090909 0.281016639508775 0.788119417370383 GO:0003725 double-stranded RNA binding 6/1100 75/18639 0.08 1.35556363636364 0.28123783718535 0.788119417370383 GO:0019003 GDP binding 6/1100 75/18639 0.08 1.35556363636364 0.28123783718535 0.788119417370383 GO:0003746 translation elongation factor activity 2/1100 18/18639 0.111111111111111 1.88272727272727 0.287741797074165 0.788119417370383 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/1100 18/18639 0.111111111111111 1.88272727272727 0.287741797074165 0.788119417370383 GO:0016854 racemase and epimerase activity 2/1100 18/18639 0.111111111111111 1.88272727272727 0.287741797074165 0.788119417370383 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/1100 18/18639 0.111111111111111 1.88272727272727 0.287741797074165 0.788119417370383 GO:0035615 clathrin adaptor activity 2/1100 18/18639 0.111111111111111 1.88272727272727 0.287741797074165 0.788119417370383 GO:0099602 neurotransmitter receptor regulator activity 2/1100 18/18639 0.111111111111111 1.88272727272727 0.287741797074165 0.788119417370383 GO:0061135 endopeptidase regulator activity 13/1100 184/18639 0.0706521739130435 1.19716897233202 0.291477174556871 0.788119417370383 GO:0017022 myosin binding 6/1100 76/18639 0.0789473684210526 1.33772727272727 0.29157226431444 0.788119417370383 GO:0051536 iron-sulfur cluster binding 6/1100 76/18639 0.0789473684210526 1.33772727272727 0.29157226431444 0.788119417370383 GO:0008378 galactosyltransferase activity 3/1100 32/18639 0.09375 1.58855113636364 0.29212148288632 0.788119417370383 GO:0030515 snoRNA binding 3/1100 32/18639 0.09375 1.58855113636364 0.29212148288632 0.788119417370383 GO:0031369 translation initiation factor binding 3/1100 32/18639 0.09375 1.58855113636364 0.29212148288632 0.788119417370383 GO:0043425 bHLH transcription factor binding 3/1100 32/18639 0.09375 1.58855113636364 0.29212148288632 0.788119417370383 GO:0070717 poly-purine tract binding 3/1100 32/18639 0.09375 1.58855113636364 0.29212148288632 0.788119417370383 GO:0071813 lipoprotein particle binding 3/1100 32/18639 0.09375 1.58855113636364 0.29212148288632 0.788119417370383 GO:0071814 protein-lipid complex binding 3/1100 32/18639 0.09375 1.58855113636364 0.29212148288632 0.788119417370383 GO:0051540 metal cluster binding 6/1100 77/18639 0.0779220779220779 1.32035419126328 0.301982523228222 0.812607517050488 GO:0004843 cysteine-type deubiquitinase activity 8/1100 108/18639 0.0740740740740741 1.25515151515151 0.305734016163535 0.815240529101679 GO:0019956 chemokine binding 3/1100 33/18639 0.0909090909090909 1.5404132231405 0.308572983690992 0.815240529101679 GO:0140311 protein sequestering activity 3/1100 33/18639 0.0909090909090909 1.5404132231405 0.308572983690992 0.815240529101679 GO:0140416 transcription regulator inhibitor activity 3/1100 33/18639 0.0909090909090909 1.5404132231405 0.308572983690992 0.815240529101679 GO:0003756 protein disulfide isomerase activity 2/1100 19/18639 0.105263157894737 1.78363636363636 0.310043212805079 0.815240529101679 GO:0015245 fatty acid transmembrane transporter activity 2/1100 19/18639 0.105263157894737 1.78363636363636 0.310043212805079 0.815240529101679 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/1100 19/18639 0.105263157894737 1.78363636363636 0.310043212805079 0.815240529101679 GO:0034987 immunoglobulin receptor binding 2/1100 19/18639 0.105263157894737 1.78363636363636 0.310043212805079 0.815240529101679 GO:0120227 acyl-CoA binding 2/1100 19/18639 0.105263157894737 1.78363636363636 0.310043212805079 0.815240529101679 GO:0051020 GTPase binding 21/1100 315/18639 0.0666666666666667 1.12963636363636 0.312989777251466 0.820904833500048 GO:0038187 pattern recognition receptor activity 4/1100 48/18639 0.0833333333333333 1.41204545454545 0.314069796122046 0.821657345410202 GO:0016835 carbon-oxygen lyase activity 6/1100 79/18639 0.0759493670886076 1.28692750287687 0.322994366785519 0.842876987379844 GO:0008175 tRNA methyltransferase activity 3/1100 34/18639 0.0882352941176471 1.49510695187166 0.325053320957219 0.846118694752961 GO:0060590 ATPase regulator activity 4/1100 49/18639 0.0816326530612245 1.38322820037106 0.32766997602838 0.847671139931936 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1100 20/18639 0.1 1.69445454545455 0.332195446730083 0.847671139931936 GO:0010851 cyclase regulator activity 2/1100 20/18639 0.1 1.69445454545455 0.332195446730083 0.847671139931936 GO:0016004 phospholipase activator activity 2/1100 20/18639 0.1 1.69445454545455 0.332195446730083 0.847671139931936 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1100 20/18639 0.1 1.69445454545455 0.332195446730083 0.847671139931936 GO:0042288 MHC class I protein binding 2/1100 20/18639 0.1 1.69445454545455 0.332195446730083 0.847671139931936 GO:0052745 inositol phosphate phosphatase activity 2/1100 20/18639 0.1 1.69445454545455 0.332195446730083 0.847671139931936 GO:0140939 histone H4 methyltransferase activity 2/1100 20/18639 0.1 1.69445454545455 0.332195446730083 0.847671139931936 GO:0160215 deacylase activity 5/1100 65/18639 0.0769230769230769 1.30342657342657 0.338040972358509 0.860467929639841 GO:0005006 epidermal growth factor receptor activity 4/1100 50/18639 0.08 1.35556363636364 0.341303013679278 0.866641966107187 GO:0015101 organic cation transmembrane transporter activity 6/1100 81/18639 0.0740740740740741 1.25515151515151 0.344201885822133 0.870395240362863 GO:0019955 cytokine binding 10/1100 144/18639 0.0694444444444444 1.17670454545455 0.344461436823141 0.870395240362863 GO:0004866 endopeptidase inhibitor activity 11/1100 161/18639 0.0683229813664596 1.15770186335404 0.352617565141539 0.876748099504966 GO:0001846 opsonin binding 2/1100 21/18639 0.0952380952380952 1.61376623376623 0.35413846987848 0.876748099504966 GO:0015174 basic amino acid transmembrane transporter activity 2/1100 21/18639 0.0952380952380952 1.61376623376623 0.35413846987848 0.876748099504966 GO:0035613 RNA stem-loop binding 2/1100 21/18639 0.0952380952380952 1.61376623376623 0.35413846987848 0.876748099504966 GO:0036122 BMP binding 2/1100 21/18639 0.0952380952380952 1.61376623376623 0.35413846987848 0.876748099504966 GO:0140312 cargo adaptor activity 2/1100 21/18639 0.0952380952380952 1.61376623376623 0.35413846987848 0.876748099504966 GO:0005021 vascular endothelial growth factor receptor activity 4/1100 51/18639 0.0784313725490196 1.32898395721925 0.354951140495706 0.876748099504966 GO:0005030 neurotrophin receptor activity 4/1100 51/18639 0.0784313725490196 1.32898395721925 0.354951140495706 0.876748099504966 GO:0000993 RNA polymerase II complex binding 3/1100 36/18639 0.0833333333333333 1.41204545454545 0.357977264566217 0.876748099504966 GO:0045505 dynein intermediate chain binding 3/1100 36/18639 0.0833333333333333 1.41204545454545 0.357977264566217 0.876748099504966 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/1100 36/18639 0.0833333333333333 1.41204545454545 0.357977264566217 0.876748099504966 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/1100 36/18639 0.0833333333333333 1.41204545454545 0.357977264566217 0.876748099504966 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/1100 36/18639 0.0833333333333333 1.41204545454545 0.357977264566217 0.876748099504966 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/1100 130/18639 0.0692307692307692 1.17308391608392 0.360142222785805 0.87997014812758 GO:0050840 extracellular matrix binding 5/1100 67/18639 0.0746268656716418 1.26451831750339 0.36181537019274 0.881978172987478 GO:0032934 sterol binding 5/1100 68/18639 0.0735294117647059 1.24592245989305 0.373722382120882 0.895202850403525 GO:0019213 deacetylase activity 3/1100 37/18639 0.0810810810810811 1.37388206388206 0.374363867284018 0.895202850403525 GO:0022829 wide pore channel activity 3/1100 37/18639 0.0810810810810811 1.37388206388206 0.374363867284018 0.895202850403525 GO:0033691 sialic acid binding 2/1100 22/18639 0.0909090909090909 1.5404132231405 0.375819845635162 0.895202850403525 GO:0034062 5'-3' RNA polymerase activity 2/1100 22/18639 0.0909090909090909 1.5404132231405 0.375819845635162 0.895202850403525 GO:0050321 tau-protein kinase activity 2/1100 22/18639 0.0909090909090909 1.5404132231405 0.375819845635162 0.895202850403525 GO:0061133 endopeptidase activator activity 2/1100 22/18639 0.0909090909090909 1.5404132231405 0.375819845635162 0.895202850403525 GO:0097747 RNA polymerase activity 2/1100 22/18639 0.0909090909090909 1.5404132231405 0.375819845635162 0.895202850403525 GO:0005544 calcium-dependent phospholipid binding 4/1100 53/18639 0.0754716981132075 1.27883361921098 0.38222491151694 0.895202850403525 GO:0002039 p53 binding 5/1100 69/18639 0.072463768115942 1.22786561264822 0.385627630854645 0.895202850403525 GO:0000146 microfilament motor activity 3/1100 38/18639 0.0789473684210526 1.33772727272727 0.390665273862848 0.895202850403525 GO:0043531 ADP binding 3/1100 38/18639 0.0789473684210526 1.33772727272727 0.390665273862848 0.895202850403525 GO:0042578 phosphoric ester hydrolase activity 23/1100 363/18639 0.0633608815426997 1.07362133734035 0.392771597180023 0.895202850403525 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/1100 54/18639 0.0740740740740741 1.25515151515151 0.395818406749244 0.895202850403525 GO:0050661 NADP binding 4/1100 54/18639 0.0740740740740741 1.25515151515151 0.395818406749244 0.895202850403525 GO:0003887 DNA-directed DNA polymerase activity 2/1100 23/18639 0.0869565217391304 1.47343873517787 0.397194044028819 0.895202850403525 GO:0004602 glutathione peroxidase activity 2/1100 23/18639 0.0869565217391304 1.47343873517787 0.397194044028819 0.895202850403525 GO:0005283 amino acid:sodium symporter activity 2/1100 23/18639 0.0869565217391304 1.47343873517787 0.397194044028819 0.895202850403525 GO:0016493 C-C chemokine receptor activity 2/1100 23/18639 0.0869565217391304 1.47343873517787 0.397194044028819 0.895202850403525 GO:0099186 structural constituent of postsynapse 2/1100 23/18639 0.0869565217391304 1.47343873517787 0.397194044028819 0.895202850403525 GO:0008237 metallopeptidase activity 12/1100 184/18639 0.0652173913043478 1.1050790513834 0.40322029965498 0.895202850403525 GO:0005201 extracellular matrix structural constituent 11/1100 168/18639 0.0654761904761905 1.10946428571429 0.405835471485915 0.895202850403525 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/1100 39/18639 0.0769230769230769 1.30342657342657 0.406857523366641 0.895202850403525 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/1100 39/18639 0.0769230769230769 1.30342657342657 0.406857523366641 0.895202850403525 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/1100 39/18639 0.0769230769230769 1.30342657342657 0.406857523366641 0.895202850403525 GO:0030414 peptidase inhibitor activity 11/1100 169/18639 0.0650887573964497 1.10289940828402 0.413480022204743 0.895202850403525 GO:0004622 lysophospholipase activity 2/1100 24/18639 0.0833333333333333 1.41204545454545 0.418221810396904 0.895202850403525 GO:0019957 C-C chemokine binding 2/1100 24/18639 0.0833333333333333 1.41204545454545 0.418221810396904 0.895202850403525 GO:0060229 lipase activator activity 2/1100 24/18639 0.0833333333333333 1.41204545454545 0.418221810396904 0.895202850403525 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1100 24/18639 0.0833333333333333 1.41204545454545 0.418221810396904 0.895202850403525 GO:0170055 lipid transmembrane transporter activity 4/1100 56/18639 0.0714285714285714 1.21032467532468 0.422843579281004 0.895202850403525 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/1100 40/18639 0.075 1.27084090909091 0.422918413775723 0.895202850403525 GO:0061791 GTPase motor activity 3/1100 40/18639 0.075 1.27084090909091 0.422918413775723 0.895202850403525 GO:0071949 FAD binding 3/1100 40/18639 0.075 1.27084090909091 0.422918413775723 0.895202850403525 GO:1990606 membrane scission GTPase motor activity 3/1100 40/18639 0.075 1.27084090909091 0.422918413775723 0.895202850403525 GO:0003727 single-stranded RNA binding 6/1100 89/18639 0.0674157303370786 1.14232890704801 0.429631414656162 0.895202850403525 GO:0140101 catalytic activity, acting on a tRNA 9/1100 139/18639 0.0647482014388489 1.09712884238064 0.436705619250115 0.895202850403525 GO:0001530 lipopolysaccharide binding 3/1100 41/18639 0.0731707317073171 1.23984478935698 0.438827458344603 0.895202850403525 GO:0017080 sodium channel regulator activity 3/1100 41/18639 0.0731707317073171 1.23984478935698 0.438827458344603 0.895202850403525 GO:0001848 complement binding 2/1100 25/18639 0.08 1.35556363636364 0.438869584406349 0.895202850403525 GO:0005537 D-mannose binding 2/1100 25/18639 0.08 1.35556363636364 0.438869584406349 0.895202850403525 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/1100 25/18639 0.08 1.35556363636364 0.438869584406349 0.895202850403525 GO:0003684 damaged DNA binding 5/1100 74/18639 0.0675675675675676 1.14490171990172 0.444761506783041 0.895202850403525 GO:0016859 cis-trans isomerase activity 3/1100 42/18639 0.0714285714285714 1.21032467532468 0.454565836263649 0.895202850403525 GO:0031492 nucleosomal DNA binding 3/1100 42/18639 0.0714285714285714 1.21032467532468 0.454565836263649 0.895202850403525 GO:0043175 RNA polymerase core enzyme binding 3/1100 42/18639 0.0714285714285714 1.21032467532468 0.454565836263649 0.895202850403525 GO:0001094 TFIID-class transcription factor complex binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0004955 prostaglandin receptor activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0005031 tumor necrosis factor receptor activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0005381 iron ion transmembrane transporter activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0008190 eukaryotic initiation factor 4E binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0008239 dipeptidyl-peptidase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0015187 glycine transmembrane transporter activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0016868 intramolecular phosphotransferase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0019911 structural constituent of myelin sheath 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0031419 cobalamin binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0031434 mitogen-activated protein kinase kinase binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0032356 oxidized DNA binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0033204 ribonuclease P RNA binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0035374 chondroitin sulfate binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0043121 neurotrophin binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0043208 glycosphingolipid binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0050308 sugar-phosphatase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0070513 death domain binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0099122 RNA polymerase II C-terminal domain binding 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0140940 histone H2A methyltransferase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:1990259 histone H2AQ104 methyltransferase activity 1/1100 10/18639 0.1 1.69445454545455 0.45580266019428 0.895202850403525 GO:0001637 G protein-coupled chemoattractant receptor activity 2/1100 26/18639 0.0769230769230769 1.30342657342657 0.459108965693588 0.895202850403525 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/1100 26/18639 0.0769230769230769 1.30342657342657 0.459108965693588 0.895202850403525 GO:0004950 chemokine receptor activity 2/1100 26/18639 0.0769230769230769 1.30342657342657 0.459108965693588 0.895202850403525 GO:0008157 protein phosphatase 1 binding 2/1100 26/18639 0.0769230769230769 1.30342657342657 0.459108965693588 0.895202850403525 GO:0043548 phosphatidylinositol 3-kinase binding 2/1100 26/18639 0.0769230769230769 1.30342657342657 0.459108965693588 0.895202850403525 GO:0070006 metalloaminopeptidase activity 2/1100 26/18639 0.0769230769230769 1.30342657342657 0.459108965693588 0.895202850403525 GO:0052689 carboxylic ester hydrolase activity 6/1100 92/18639 0.0652173913043478 1.1050790513834 0.461355300413615 0.895202850403525 GO:0004879 nuclear receptor activity 4/1100 59/18639 0.0677966101694915 1.14878274268105 0.462773447761749 0.895202850403525 GO:0004222 metalloendopeptidase activity 7/1100 110/18639 0.0636363636363636 1.07828925619835 0.474733258297604 0.895202850403525 GO:0001098 basal transcription machinery binding 4/1100 60/18639 0.0666666666666667 1.12963636363636 0.475872175456523 0.895202850403525 GO:0001099 basal RNA polymerase II transcription machinery binding 4/1100 60/18639 0.0666666666666667 1.12963636363636 0.475872175456523 0.895202850403525 GO:0098531 ligand-modulated transcription factor activity 4/1100 60/18639 0.0666666666666667 1.12963636363636 0.475872175456523 0.895202850403525 GO:0005543 phospholipid binding 30/1100 497/18639 0.0603621730382294 1.02280958478142 0.476270777740832 0.895202850403525 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1100 27/18639 0.0740740740740741 1.25515151515151 0.478916222652478 0.895202850403525 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/1100 27/18639 0.0740740740740741 1.25515151515151 0.478916222652478 0.895202850403525 GO:0035255 ionotropic glutamate receptor binding 2/1100 27/18639 0.0740740740740741 1.25515151515151 0.478916222652478 0.895202850403525 GO:1902936 phosphatidylinositol bisphosphate binding 7/1100 111/18639 0.0630630630630631 1.06857493857494 0.484315533471838 0.895202850403525 GO:0001046 core promoter sequence-specific DNA binding 3/1100 44/18639 0.0681818181818182 1.15530991735537 0.485463311362235 0.895202850403525 GO:0031490 chromatin DNA binding 8/1100 128/18639 0.0625 1.05903409090909 0.485974255531073 0.895202850403525 GO:0030246 carbohydrate binding 17/1100 280/18639 0.0607142857142857 1.02877597402597 0.487850690102653 0.895202850403525 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0004954 prostanoid receptor activity 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0008172 S-methyltransferase activity 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0008199 ferric iron binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0008432 JUN kinase binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0016594 glycine binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0019203 carbohydrate phosphatase activity 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0019215 intermediate filament binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0034056 estrogen response element binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0034713 type I transforming growth factor beta receptor binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0048185 activin binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0070990 snRNP binding 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0180030 inositol phosphate kinase activity 1/1100 11/18639 0.0909090909090909 1.5404132231405 0.487936273044476 0.895202850403525 GO:0016836 hydro-lyase activity 4/1100 61/18639 0.0655737704918033 1.11111773472429 0.488846929425364 0.895202850403525 GO:0019199 transmembrane receptor protein kinase activity 5/1100 78/18639 0.0641025641025641 1.08618881118881 0.491031863585994 0.895202850403525 GO:0004867 serine-type endopeptidase inhibitor activity 6/1100 95/18639 0.0631578947368421 1.07018181818182 0.492615817880259 0.895202850403525 GO:0036408 histone H3K14 acetyltransferase activity 2/1100 28/18639 0.0714285714285714 1.21032467532468 0.498271841145523 0.895202850403525 GO:0046625 sphingolipid binding 2/1100 28/18639 0.0714285714285714 1.21032467532468 0.498271841145523 0.895202850403525 GO:0051393 alpha-actinin binding 2/1100 28/18639 0.0714285714285714 1.21032467532468 0.498271841145523 0.895202850403525 GO:0051537 2 iron, 2 sulfur cluster binding 2/1100 28/18639 0.0714285714285714 1.21032467532468 0.498271841145523 0.895202850403525 GO:0051959 dynein light intermediate chain binding 2/1100 28/18639 0.0714285714285714 1.21032467532468 0.498271841145523 0.895202850403525 GO:0042605 peptide antigen binding 3/1100 45/18639 0.0666666666666667 1.12963636363636 0.500592593936334 0.895202850403525 GO:0015179 L-amino acid transmembrane transporter activity 4/1100 62/18639 0.0645161290322581 1.09319648093842 0.50168776042484 0.895202850403525 GO:0005507 copper ion binding 4/1100 63/18639 0.0634920634920635 1.07584415584416 0.514385414746354 0.895202850403525 GO:1901682 sulfur compound transmembrane transporter activity 4/1100 63/18639 0.0634920634920635 1.07584415584416 0.514385414746354 0.895202850403525 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/1100 46/18639 0.0652173913043478 1.1050790513834 0.515491458003456 0.895202850403525 GO:0030276 clathrin binding 3/1100 46/18639 0.0652173913043478 1.1050790513834 0.515491458003456 0.895202850403525 GO:0005416 amino acid:monoatomic cation symporter activity 2/1100 29/18639 0.0689655172413793 1.16858934169279 0.517160110143594 0.895202850403525 GO:0010484 histone H3 acetyltransferase activity 2/1100 29/18639 0.0689655172413793 1.16858934169279 0.517160110143594 0.895202850403525 GO:0140098 catalytic activity, acting on RNA 23/1100 387/18639 0.0594315245478036 1.00704016913319 0.517203651615948 0.895202850403525 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0003995 acyl-CoA dehydrogenase activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0004000 adenosine deaminase activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0004032 aldose reductase (NADPH) activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0004526 ribonuclease P activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0004875 complement receptor activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0005078 MAP-kinase scaffold activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0010853 cyclase activator activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0016208 AMP binding 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0016273 arginine N-methyltransferase activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0016274 protein-arginine N-methyltransferase activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0016801 hydrolase activity, acting on ether bonds 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0016803 ether hydrolase activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0036009 protein-glutamine N-methyltransferase activity 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0045295 gamma-catenin binding 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0070410 co-SMAD binding 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0097677 STAT family protein binding 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1100 12/18639 0.0833333333333333 1.41204545454545 0.518174092437383 0.895202850403525 GO:0005125 cytokine activity 14/1100 234/18639 0.0598290598290598 1.01377622377622 0.518433664877575 0.895202850403525 GO:0005179 hormone activity 8/1100 132/18639 0.0606060606060606 1.02694214876033 0.521204545823237 0.895202850403525 GO:0030971 receptor tyrosine kinase binding 5/1100 81/18639 0.0617283950617284 1.0459595959596 0.524786811244782 0.895202850403525 GO:0061659 ubiquitin-like protein ligase activity 22/1100 372/18639 0.0591397849462366 1.00209677419355 0.527718636876955 0.895202850403525 GO:0019842 vitamin binding 9/1100 150/18639 0.06 1.01667272727273 0.528668800468306 0.895202850403525 GO:0140938 histone H3 methyltransferase activity 3/1100 47/18639 0.0638297872340425 1.0815667311412 0.530148543249425 0.895202850403525 GO:0016769 transferase activity, transferring nitrogenous groups 2/1100 30/18639 0.0666666666666667 1.12963636363636 0.53556874151331 0.895202850403525 GO:0033612 receptor serine/threonine kinase binding 2/1100 30/18639 0.0666666666666667 1.12963636363636 0.53556874151331 0.895202850403525 GO:0043995 histone H4K5 acetyltransferase activity 2/1100 30/18639 0.0666666666666667 1.12963636363636 0.53556874151331 0.895202850403525 GO:0043996 histone H4K8 acetyltransferase activity 2/1100 30/18639 0.0666666666666667 1.12963636363636 0.53556874151331 0.895202850403525 GO:0043997 histone H4K12 acetyltransferase activity 2/1100 30/18639 0.0666666666666667 1.12963636363636 0.53556874151331 0.895202850403525 GO:0098918 structural constituent of synapse 2/1100 30/18639 0.0666666666666667 1.12963636363636 0.53556874151331 0.895202850403525 GO:1990782 protein tyrosine kinase binding 7/1100 117/18639 0.0598290598290598 1.01377622377622 0.540603541756006 0.895202850403525 GO:0032266 phosphatidylinositol-3-phosphate binding 3/1100 48/18639 0.0625 1.05903409090909 0.544553793057917 0.895202850403525 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0005035 death receptor activity 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0005172 vascular endothelial growth factor receptor binding 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0008035 high-density lipoprotein particle binding 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0039706 co-receptor binding 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0043560 insulin receptor substrate binding 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0045159 myosin II binding 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0046974 histone H3K9 methyltransferase activity 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0051011 microtubule minus-end binding 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0140852 histone ubiquitin ligase activity 1/1100 13/18639 0.0769230769230769 1.30342657342657 0.54662786912278 0.895202850403525 GO:0001540 amyloid-beta binding 5/1100 83/18639 0.0602409638554217 1.02075575027382 0.546736963079806 0.895202850403525 GO:0016755 aminoacyltransferase activity 29/1100 496/18639 0.0584677419354839 0.99070931085044 0.548767734465834 0.895202850403525 GO:0019787 ubiquitin-like protein transferase activity 28/1100 479/18639 0.058455114822547 0.990495350161321 0.54932593231242 0.895202850403525 GO:0008235 metalloexopeptidase activity 4/1100 66/18639 0.0606060606060606 1.02694214876033 0.551536916771281 0.895202850403525 GO:0017147 Wnt-protein binding 2/1100 31/18639 0.0645161290322581 1.09319648093842 0.553488521370393 0.895202850403525 GO:0047499 calcium-independent phospholipase A2 activity 2/1100 31/18639 0.0645161290322581 1.09319648093842 0.553488521370393 0.895202850403525 GO:0001222 transcription corepressor binding 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0005004 GPI-linked ephrin receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0005008 hepatocyte growth factor receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0005009 insulin receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0005011 macrophage colony-stimulating factor receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0005020 stem cell factor receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0008288 boss receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0036332 placental growth factor receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0038062 protein tyrosine kinase collagen receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:0060175 brain-derived neurotrophic factor receptor activity 3/1100 49/18639 0.0612244897959184 1.03742115027829 0.558698389820713 0.895202850403525 GO:1901681 sulfur compound binding 16/1100 275/18639 0.0581818181818182 0.985864462809917 0.560392505510625 0.895202850403525 GO:0008238 exopeptidase activity 6/1100 102/18639 0.0588235294117647 0.996737967914439 0.562886778144684 0.895202850403525 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/1100 67/18639 0.0597014925373134 1.01161465400271 0.563582729252458 0.895202850403525 GO:0004386 helicase activity 9/1100 155/18639 0.0580645161290323 0.983876832844575 0.568761330155202 0.895202850403525 GO:0004842 ubiquitin-protein transferase activity 26/1100 449/18639 0.0579064587973274 0.981198623203078 0.569387899734637 0.895202850403525 GO:0022884 macromolecule transmembrane transporter activity 2/1100 32/18639 0.0625 1.05903409090909 0.570912990602665 0.895202850403525 GO:0042910 xenobiotic transmembrane transporter activity 2/1100 32/18639 0.0625 1.05903409090909 0.570912990602665 0.895202850403525 GO:0047498 calcium-dependent phospholipase A2 activity 2/1100 32/18639 0.0625 1.05903409090909 0.570912990602665 0.895202850403525 GO:0120015 sterol transfer activity 2/1100 32/18639 0.0625 1.05903409090909 0.570912990602665 0.895202850403525 GO:0140142 nucleocytoplasmic carrier activity 2/1100 32/18639 0.0625 1.05903409090909 0.570912990602665 0.895202850403525 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 28/1100 484/18639 0.0578512396694215 0.980262960180316 0.572024632333517 0.895202850403525 GO:0005253 monoatomic anion channel activity 6/1100 103/18639 0.058252427184466 0.987060900264784 0.572549167237242 0.895202850403525 GO:0005007 fibroblast growth factor receptor activity 3/1100 50/18639 0.06 1.01667272727273 0.572574690425485 0.895202850403525 GO:0005017 platelet-derived growth factor receptor activity 3/1100 50/18639 0.06 1.01667272727273 0.572574690425485 0.895202850403525 GO:0005019 platelet-derived growth factor beta-receptor activity 3/1100 50/18639 0.06 1.01667272727273 0.572574690425485 0.895202850403525 GO:0004065 arylsulfatase activity 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0005161 platelet-derived growth factor receptor binding 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0005313 L-glutamate transmembrane transporter activity 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0008559 ABC-type xenobiotic transporter activity 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0016530 metallochaperone activity 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0019763 immunoglobulin receptor activity 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0019992 diacylglycerol binding 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0032036 myosin heavy chain binding 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0042813 Wnt receptor activity 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0044548 S100 protein binding 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:1901612 cardiolipin binding 1/1100 14/18639 0.0714285714285714 1.21032467532468 0.573402772159661 0.895202850403525 GO:0004540 RNA nuclease activity 7/1100 121/18639 0.0578512396694215 0.980262960180316 0.576683810319695 0.895202850403525 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/1100 86/18639 0.0581395348837209 0.98514799154334 0.578720015153565 0.895202850403525 GO:0050660 flavin adenine dinucleotide binding 5/1100 86/18639 0.0581395348837209 0.98514799154334 0.578720015153565 0.895202850403525 GO:0016887 ATP hydrolysis activity 24/1100 417/18639 0.0575539568345324 0.975225637671681 0.581182783701352 0.895202850403525 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/1100 122/18639 0.0573770491803279 0.972228017883756 0.585490908726198 0.895202850403525 GO:0005010 insulin-like growth factor receptor activity 3/1100 51/18639 0.0588235294117647 0.996737967914439 0.586176162296096 0.895202850403525 GO:0016597 amino acid binding 3/1100 51/18639 0.0588235294117647 0.996737967914439 0.586176162296096 0.895202850403525 GO:0001664 G protein-coupled receptor binding 17/1100 297/18639 0.0572390572390572 0.969889807162535 0.587632023370245 0.895202850403525 GO:0008094 ATP-dependent activity, acting on DNA 12/1100 210/18639 0.0571428571428571 0.96825974025974 0.588125294392961 0.895202850403525 GO:0004559 alpha-mannosidase activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0004953 icosanoid receptor activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0005041 low-density lipoprotein particle receptor activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0005523 tropomyosin binding 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0010181 FMN binding 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0015116 sulfate transmembrane transporter activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0015929 hexosaminidase activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0016846 carbon-sulfur lyase activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0042809 nuclear vitamin D receptor binding 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0050700 CARD domain binding 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0050780 dopamine receptor binding 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0051371 muscle alpha-actinin binding 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0141050 histone H3K deacetylase activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0141051 histone H4K deacetylase activity 1/1100 15/18639 0.0666666666666667 1.12963636363636 0.598597776220029 0.895202850403525 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/1100 70/18639 0.0571428571428571 0.96825974025974 0.598621831902891 0.895202850403525 GO:0016782 transferase activity, transferring sulphur-containing groups 4/1100 70/18639 0.0571428571428571 0.96825974025974 0.598621831902891 0.895202850403525 GO:0004197 cysteine-type endopeptidase activity 5/1100 88/18639 0.0568181818181818 0.96275826446281 0.599359232355656 0.895202850403525 GO:0001216 DNA-binding transcription activator activity 28/1100 491/18639 0.0570264765784114 0.966287724495464 0.603135091082812 0.895202850403525 GO:0015020 glucuronosyltransferase activity 2/1100 34/18639 0.0588235294117647 0.996737967914439 0.604262204300257 0.895202850403525 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1100 34/18639 0.0588235294117647 0.996737967914439 0.604262204300257 0.895202850403525 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1100 34/18639 0.0588235294117647 0.996737967914439 0.604262204300257 0.895202850403525 GO:0090482 vitamin transmembrane transporter activity 2/1100 34/18639 0.0588235294117647 0.996737967914439 0.604262204300257 0.895202850403525 GO:0000287 magnesium ion binding 13/1100 230/18639 0.0565217391304348 0.957735177865613 0.604379868806563 0.895202850403525 GO:0022804 active transmembrane transporter activity 26/1100 457/18639 0.0568927789934354 0.964022279689676 0.60621808190906 0.895202850403525 GO:0003689 DNA clamp loader activity 9/1100 160/18639 0.05625 0.953130681818182 0.607314512396 0.895202850403525 GO:0061630 ubiquitin protein ligase activity 20/1100 353/18639 0.056657223796034 0.960030903940252 0.607984770894421 0.895202850403525 GO:0005003 ephrin receptor activity 3/1100 53/18639 0.0566037735849057 0.959125214408233 0.612533664832896 0.895202850403525 GO:0005005 transmembrane-ephrin receptor activity 3/1100 53/18639 0.0566037735849057 0.959125214408233 0.612533664832896 0.895202850403525 GO:0005246 calcium channel regulator activity 3/1100 53/18639 0.0566037735849057 0.959125214408233 0.612533664832896 0.895202850403525 GO:0017046 peptide hormone binding 3/1100 53/18639 0.0566037735849057 0.959125214408233 0.612533664832896 0.895202850403525 GO:0038064 collagen receptor activity 3/1100 53/18639 0.0566037735849057 0.959125214408233 0.612533664832896 0.895202850403525 GO:0140296 general transcription initiation factor binding 3/1100 53/18639 0.0566037735849057 0.959125214408233 0.612533664832896 0.895202850403525 GO:0005496 steroid binding 6/1100 108/18639 0.0555555555555556 0.941363636363636 0.6191988547165 0.895202850403525 GO:0000175 3'-5'-RNA exonuclease activity 2/1100 35/18639 0.0571428571428571 0.96825974025974 0.620185294120317 0.895202850403525 GO:0004623 phospholipase A2 activity 2/1100 35/18639 0.0571428571428571 0.96825974025974 0.620185294120317 0.895202850403525 GO:0005154 epidermal growth factor receptor binding 2/1100 35/18639 0.0571428571428571 0.96825974025974 0.620185294120317 0.895202850403525 GO:0005343 organic acid:sodium symporter activity 2/1100 35/18639 0.0571428571428571 0.96825974025974 0.620185294120317 0.895202850403525 GO:0010485 histone H4 acetyltransferase activity 2/1100 35/18639 0.0571428571428571 0.96825974025974 0.620185294120317 0.895202850403525 GO:0034061 DNA polymerase activity 2/1100 35/18639 0.0571428571428571 0.96825974025974 0.620185294120317 0.895202850403525 GO:0043015 gamma-tubulin binding 2/1100 35/18639 0.0571428571428571 0.96825974025974 0.620185294120317 0.895202850403525 GO:0005518 collagen binding 4/1100 72/18639 0.0555555555555556 0.941363636363636 0.621018835789251 0.895202850403525 GO:0008083 growth factor activity 9/1100 162/18639 0.0555555555555556 0.941363636363636 0.622244999224088 0.895202850403525 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0004708 MAP kinase kinase activity 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0008142 oxysterol binding 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0015562 efflux transmembrane transporter activity 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0015923 mannosidase activity 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0017070 U6 snRNA binding 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0022858 alanine transmembrane transporter activity 1/1100 16/18639 0.0625 1.05903409090909 0.622306026121123 0.895202850403525 GO:0015485 cholesterol binding 3/1100 54/18639 0.0555555555555556 0.941363636363636 0.625281621190758 0.895202850403525 GO:0017069 snRNA binding 3/1100 54/18639 0.0555555555555556 0.941363636363636 0.625281621190758 0.895202850403525 GO:0004521 RNA endonuclease activity 4/1100 73/18639 0.0547945205479452 0.928468244084682 0.631917314516391 0.895202850403525 GO:0016409 palmitoyltransferase activity 2/1100 36/18639 0.0555555555555556 0.941363636363636 0.635609295858793 0.895202850403525 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/1100 36/18639 0.0555555555555556 0.941363636363636 0.635609295858793 0.895202850403525 GO:0140713 histone chaperone activity 9/1100 164/18639 0.0548780487804878 0.929883592017738 0.636873525963785 0.895202850403525 GO:0008374 O-acyltransferase activity 3/1100 55/18639 0.0545454545454545 0.924247933884297 0.637738480612604 0.895202850403525 GO:0003678 DNA helicase activity 4/1100 74/18639 0.0540540540540541 0.915921375921376 0.642611932101154 0.895202850403525 GO:0031491 nucleosome binding 4/1100 74/18639 0.0540540540540541 0.915921375921376 0.642611932101154 0.895202850403525 GO:0035064 methylated histone binding 4/1100 74/18639 0.0540540540540541 0.915921375921376 0.642611932101154 0.895202850403525 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0004549 tRNA-specific ribonuclease activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0004550 nucleoside diphosphate kinase activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0004659 prenyltransferase activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0008484 sulfuric ester hydrolase activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0008569 minus-end-directed microtubule motor activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0016018 cyclosporin A binding 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0016805 dipeptidase activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0019198 transmembrane receptor protein phosphatase activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0031489 myosin V binding 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0032183 SUMO binding 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0032977 membrane insertase activity 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0045236 CXCR chemokine receptor binding 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0048038 quinone binding 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0070403 NAD+ binding 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0070492 oligosaccharide binding 1/1100 17/18639 0.0588235294117647 0.996737967914439 0.644615179923774 0.895202850403525 GO:0030551 cyclic nucleotide binding 2/1100 37/18639 0.0540540540540541 0.915921375921376 0.650537606063066 0.902218152451588 GO:1901981 phosphatidylinositol phosphate binding 10/1100 185/18639 0.0540540540540541 0.915921375921376 0.658024270595114 0.904502323099044 GO:0140034 methylation-dependent protein binding 4/1100 76/18639 0.0526315789473684 0.891818181818182 0.663380841700586 0.904502323099044 GO:0005501 retinoid binding 2/1100 38/18639 0.0526315789473684 0.891818181818182 0.664974957851967 0.904502323099044 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/1100 38/18639 0.0526315789473684 0.891818181818182 0.664974957851967 0.904502323099044 GO:0019840 isoprenoid binding 2/1100 38/18639 0.0526315789473684 0.891818181818182 0.664974957851967 0.904502323099044 GO:0042887 amide transmembrane transporter activity 2/1100 38/18639 0.0526315789473684 0.891818181818182 0.664974957851967 0.904502323099044 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:0015172 acidic amino acid transmembrane transporter activity 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:0017128 phospholipid scramblase activity 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:0030228 lipoprotein particle receptor activity 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:0034185 apolipoprotein binding 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:0050811 GABA receptor binding 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:1901611 phosphatidylglycerol binding 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:1990381 ubiquitin-specific protease binding 1/1100 18/18639 0.0555555555555556 0.941363636363636 0.665607731856104 0.904502323099044 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 7/1100 132/18639 0.053030303030303 0.898574380165289 0.668152663374093 0.904502323099044 GO:0008234 cysteine-type peptidase activity 10/1100 187/18639 0.053475935828877 0.906125425376762 0.67119155666626 0.904502323099044 GO:0017116 single-stranded DNA helicase activity 3/1100 58/18639 0.0517241379310345 0.876442006269592 0.673347188037365 0.904502323099044 GO:0003724 RNA helicase activity 4/1100 77/18639 0.051948051948052 0.880236127508855 0.673451851076261 0.904502323099044 GO:0000510 H3-H4 histone complex chaperone activity 8/1100 151/18639 0.0529801324503311 0.897724262492474 0.673516923639917 0.904502323099044 GO:0140584 chromatin extrusion motor activity 8/1100 151/18639 0.0529801324503311 0.897724262492474 0.673516923639917 0.904502323099044 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 8/1100 151/18639 0.0529801324503311 0.897724262492474 0.673516923639917 0.904502323099044 GO:0140849 ATP-dependent H2AZ histone chaperone activity 8/1100 151/18639 0.0529801324503311 0.897724262492474 0.673516923639917 0.904502323099044 GO:0004896 cytokine receptor activity 5/1100 96/18639 0.0520833333333333 0.882528409090909 0.675865738798763 0.904502323099044 GO:0140597 protein carrier chaperone 10/1100 188/18639 0.0531914893617021 0.901305609284333 0.677662774191197 0.904502323099044 GO:0015616 DNA translocase activity 8/1100 152/18639 0.0526315789473684 0.891818181818182 0.680663892091905 0.904502323099044 GO:0140674 ATP-dependent histone chaperone activity 8/1100 152/18639 0.0526315789473684 0.891818181818182 0.680663892091905 0.904502323099044 GO:0005516 calmodulin binding 11/1100 207/18639 0.0531400966183575 0.900434782608696 0.683115100010766 0.904502323099044 GO:0015459 potassium channel regulator activity 3/1100 59/18639 0.0508474576271186 0.861587057010786 0.684627924123559 0.904502323099044 GO:0070888 E-box binding 3/1100 59/18639 0.0508474576271186 0.861587057010786 0.684627924123559 0.904502323099044 GO:0008574 plus-end-directed microtubule motor activity 1/1100 19/18639 0.0526315789473684 0.891818181818182 0.685361316247827 0.904502323099044 GO:0030506 ankyrin binding 1/1100 19/18639 0.0526315789473684 0.891818181818182 0.685361316247827 0.904502323099044 GO:0042800 histone H3K4 methyltransferase activity 1/1100 19/18639 0.0526315789473684 0.891818181818182 0.685361316247827 0.904502323099044 GO:0043395 heparan sulfate proteoglycan binding 1/1100 19/18639 0.0526315789473684 0.891818181818182 0.685361316247827 0.904502323099044 GO:0046527 glucosyltransferase activity 1/1100 19/18639 0.0526315789473684 0.891818181818182 0.685361316247827 0.904502323099044 GO:0046624 sphingolipid transporter activity 1/1100 19/18639 0.0526315789473684 0.891818181818182 0.685361316247827 0.904502323099044 GO:0050145 nucleoside monophosphate kinase activity 1/1100 19/18639 0.0526315789473684 0.891818181818182 0.685361316247827 0.904502323099044 GO:0097001 ceramide binding 1/1100 19/18639 0.0526315789473684 0.891818181818182 0.685361316247827 0.904502323099044 GO:0061775 cohesin loader activity 8/1100 153/18639 0.0522875816993464 0.885989304812834 0.687713345469504 0.905458745582694 GO:0003730 mRNA 3'-UTR binding 14/1100 262/18639 0.0534351145038168 0.905433726578765 0.687834008468707 0.905458745582694 GO:0004532 RNA exonuclease activity 2/1100 40/18639 0.05 0.847227272727273 0.692401400967521 0.908158522803073 GO:0071855 neuropeptide receptor binding 2/1100 40/18639 0.05 0.847227272727273 0.692401400967521 0.908158522803073 GO:0008186 ATP-dependent activity, acting on RNA 4/1100 79/18639 0.0506329113924051 0.85795166858458 0.692961811870502 0.908158522803073 GO:0008170 N-methyltransferase activity 5/1100 98/18639 0.0510204081632653 0.864517625231911 0.693391304572617 0.908158522803073 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 3/1100 60/18639 0.05 0.847227272727273 0.695615068790245 0.909920721296331 GO:0031267 small GTPase binding 15/1100 283/18639 0.0530035335689046 0.89812078380983 0.703361938298993 0.910073706046918 GO:0001972 retinoic acid binding 1/1100 20/18639 0.05 0.847227272727273 0.703948993590866 0.910073706046918 GO:0016408 C-acyltransferase activity 1/1100 20/18639 0.05 0.847227272727273 0.703948993590866 0.910073706046918 GO:0030742 GTP-dependent protein binding 1/1100 20/18639 0.05 0.847227272727273 0.703948993590866 0.910073706046918 GO:0031418 L-ascorbic acid binding 1/1100 20/18639 0.05 0.847227272727273 0.703948993590866 0.910073706046918 GO:0140664 ATP-dependent DNA damage sensor activity 1/1100 20/18639 0.05 0.847227272727273 0.703948993590866 0.910073706046918 GO:0001727 lipid kinase activity 2/1100 41/18639 0.0487804878048781 0.826563192904656 0.705405192896901 0.910073706046918 GO:0004812 aminoacyl-tRNA ligase activity 2/1100 41/18639 0.0487804878048781 0.826563192904656 0.705405192896901 0.910073706046918 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/1100 41/18639 0.0487804878048781 0.826563192904656 0.705405192896901 0.910073706046918 GO:0016875 ligase activity, forming carbon-oxygen bonds 2/1100 41/18639 0.0487804878048781 0.826563192904656 0.705405192896901 0.910073706046918 GO:0042287 MHC protein binding 2/1100 41/18639 0.0487804878048781 0.826563192904656 0.705405192896901 0.910073706046918 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/1100 61/18639 0.0491803278688525 0.833338301043219 0.706309972550498 0.910073706046918 GO:0004402 histone acetyltransferase activity 2/1100 42/18639 0.0476190476190476 0.806883116883117 0.717947160728563 0.910073706046918 GO:0048487 beta-tubulin binding 2/1100 42/18639 0.0476190476190476 0.806883116883117 0.717947160728563 0.910073706046918 GO:0140767 enzyme-substrate adaptor activity 7/1100 139/18639 0.0503597122302158 0.853322432962721 0.71953674999926 0.910073706046918 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1100 21/18639 0.0476190476190476 0.806883116883117 0.721439519776486 0.910073706046918 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1100 21/18639 0.0476190476190476 0.806883116883117 0.721439519776486 0.910073706046918 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/1100 21/18639 0.0476190476190476 0.806883116883117 0.721439519776486 0.910073706046918 GO:0009975 cyclase activity 1/1100 21/18639 0.0476190476190476 0.806883116883117 0.721439519776486 0.910073706046918 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1100 21/18639 0.0476190476190476 0.806883116883117 0.721439519776486 0.910073706046918 GO:0019200 carbohydrate kinase activity 1/1100 21/18639 0.0476190476190476 0.806883116883117 0.721439519776486 0.910073706046918 GO:0051428 peptide hormone receptor binding 1/1100 21/18639 0.0476190476190476 0.806883116883117 0.721439519776486 0.910073706046918 GO:0061891 calcium ion sensor activity 1/1100 21/18639 0.0476190476190476 0.806883116883117 0.721439519776486 0.910073706046918 GO:0140658 ATP-dependent chromatin remodeler activity 8/1100 158/18639 0.0506329113924051 0.85795166858458 0.721470430402702 0.910073706046918 GO:0016741 transferase activity, transferring one-carbon groups 11/1100 215/18639 0.0511627906976744 0.86693023255814 0.729579355769322 0.910073706046918 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/1100 43/18639 0.0465116279069767 0.788118393234672 0.730036469119011 0.910073706046918 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/1100 122/18639 0.0491803278688525 0.833338301043219 0.733015775408562 0.910073706046918 GO:0099106 ion channel regulator activity 8/1100 160/18639 0.05 0.847227272727273 0.734267352262891 0.910073706046918 GO:0004407 histone deacetylase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0005243 gap junction channel activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0032931 histone H3K56 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0033558 protein lysine deacetylase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0043992 histone H3K9 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0043993 histone H3K18 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0043994 histone H3K23 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0043999 histone H2AK5 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0044012 histone H2AK9 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0044014 histone H2BK5 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0044015 histone H2BK12 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0044016 histone H3K4 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0044017 histone H3K27 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0044018 histone H3K36 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0046972 histone H4K16 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0140784 metal ion sensor activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0140908 histone H3K122 acetyltransferase activity 1/1100 22/18639 0.0454545454545455 0.770206611570248 0.737897599497501 0.910073706046918 GO:0016790 thiolester hydrolase activity 2/1100 44/18639 0.0454545454545455 0.770206611570248 0.741682809964572 0.911600522016605 GO:0043014 alpha-tubulin binding 2/1100 44/18639 0.0454545454545455 0.770206611570248 0.741682809964572 0.911600522016605 GO:0016829 lyase activity 10/1100 200/18639 0.05 0.847227272727273 0.749195228222752 0.911600522016605 GO:0051539 4 iron, 4 sulfur cluster binding 2/1100 45/18639 0.0444444444444444 0.753090909090909 0.75289630838449 0.911600522016605 GO:0005126 cytokine receptor binding 14/1100 275/18639 0.0509090909090909 0.862631404958678 0.753283911146663 0.911600522016605 GO:0005212 structural constituent of eye lens 1/1100 23/18639 0.0434782608695652 0.736719367588933 0.753384124746078 0.911600522016605 GO:0031681 G-protein beta-subunit binding 1/1100 23/18639 0.0434782608695652 0.736719367588933 0.753384124746078 0.911600522016605 GO:0042171 lysophosphatidic acid acyltransferase activity 1/1100 23/18639 0.0434782608695652 0.736719367588933 0.753384124746078 0.911600522016605 GO:0044013 histone H2B acetyltransferase activity 1/1100 23/18639 0.0434782608695652 0.736719367588933 0.753384124746078 0.911600522016605 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/1100 23/18639 0.0434782608695652 0.736719367588933 0.753384124746078 0.911600522016605 GO:0071617 lysophospholipid acyltransferase activity 1/1100 23/18639 0.0434782608695652 0.736719367588933 0.753384124746078 0.911600522016605 GO:0140103 catalytic activity, acting on a glycoprotein 1/1100 23/18639 0.0434782608695652 0.736719367588933 0.753384124746078 0.911600522016605 GO:0008081 phosphoric diester hydrolase activity 4/1100 87/18639 0.0459770114942529 0.779059561128527 0.762588161215938 0.911600522016605 GO:0004180 carboxypeptidase activity 2/1100 46/18639 0.0434782608695652 0.736719367588933 0.763687437947264 0.911600522016605 GO:0008173 RNA methyltransferase activity 3/1100 67/18639 0.0447761194029851 0.758710990502035 0.764476437486713 0.911600522016605 GO:0016500 protein-hormone receptor activity 3/1100 67/18639 0.0447761194029851 0.758710990502035 0.764476437486713 0.911600522016605 GO:0042054 histone methyltransferase activity 3/1100 67/18639 0.0447761194029851 0.758710990502035 0.764476437486713 0.911600522016605 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0015149 hexose transmembrane transporter activity 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0030552 cAMP binding 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0043998 histone H2A acetyltransferase activity 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0055056 D-glucose transmembrane transporter activity 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0070300 phosphatidic acid binding 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0140612 DNA damage sensor activity 1/1100 24/18639 0.0416666666666667 0.706022727272727 0.767956399282998 0.911600522016605 GO:0008168 methyltransferase activity 10/1100 204/18639 0.0490196078431373 0.830614973262032 0.77045437762852 0.911600522016605 GO:0030145 manganese ion binding 3/1100 68/18639 0.0441176470588235 0.747553475935829 0.773200780711568 0.911600522016605 GO:1990841 promoter-specific chromatin binding 3/1100 68/18639 0.0441176470588235 0.747553475935829 0.773200780711568 0.911600522016605 GO:0061733 protein-lysine-acetyltransferase activity 2/1100 47/18639 0.0425531914893617 0.721044487427466 0.774066944378279 0.911600522016605 GO:0061749 forked DNA-dependent helicase activity 2/1100 47/18639 0.0425531914893617 0.721044487427466 0.774066944378279 0.911600522016605 GO:0140359 ABC-type transporter activity 2/1100 47/18639 0.0425531914893617 0.721044487427466 0.774066944378279 0.911600522016605 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/1100 47/18639 0.0425531914893617 0.721044487427466 0.774066944378279 0.911600522016605 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 8/1100 167/18639 0.0479041916167665 0.811714752313555 0.775847072900772 0.911600522016605 GO:0016874 ligase activity 8/1100 167/18639 0.0479041916167665 0.811714752313555 0.775847072900772 0.911600522016605 GO:0004620 phospholipase activity 5/1100 109/18639 0.0458715596330275 0.777272727272727 0.77797906759789 0.911600522016605 GO:0035591 signaling adaptor activity 6/1100 129/18639 0.0465116279069767 0.788118393234672 0.77998586665932 0.911600522016605 GO:0016247 channel regulator activity 8/1100 168/18639 0.0476190476190476 0.806883116883117 0.781380562872473 0.911600522016605 GO:0008080 N-acetyltransferase activity 3/1100 69/18639 0.0434782608695652 0.736719367588933 0.781658529106146 0.911600522016605 GO:0016279 protein-lysine N-methyltransferase activity 3/1100 69/18639 0.0434782608695652 0.736719367588933 0.781658529106146 0.911600522016605 GO:0017025 TBP-class protein binding 1/1100 25/18639 0.04 0.677781818181818 0.781668349902859 0.911600522016605 GO:0017056 structural constituent of nuclear pore 1/1100 25/18639 0.04 0.677781818181818 0.781668349902859 0.911600522016605 GO:0047617 fatty acyl-CoA hydrolase activity 1/1100 25/18639 0.04 0.677781818181818 0.781668349902859 0.911600522016605 GO:0120020 cholesterol transfer activity 1/1100 25/18639 0.04 0.677781818181818 0.781668349902859 0.911600522016605 GO:0009378 four-way junction helicase activity 2/1100 48/18639 0.0416666666666667 0.706022727272727 0.784045777044381 0.911600522016605 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/1100 48/18639 0.0416666666666667 0.706022727272727 0.784045777044381 0.911600522016605 GO:0036121 double-stranded DNA helicase activity 2/1100 48/18639 0.0416666666666667 0.706022727272727 0.784045777044381 0.911600522016605 GO:0043138 3'-5' DNA helicase activity 2/1100 48/18639 0.0416666666666667 0.706022727272727 0.784045777044381 0.911600522016605 GO:0016278 lysine N-methyltransferase activity 3/1100 70/18639 0.0428571428571429 0.726194805194805 0.789854202115247 0.911600522016605 GO:0141108 transporter regulator activity 8/1100 170/18639 0.0470588235294118 0.797390374331551 0.792145662654287 0.911600522016605 GO:0035091 phosphatidylinositol binding 14/1100 284/18639 0.0492957746478873 0.835294494238156 0.792861937668937 0.911600522016605 GO:0035254 glutamate receptor binding 2/1100 49/18639 0.0408163265306122 0.691614100185529 0.793635027564538 0.911600522016605 GO:0005112 Notch binding 1/1100 26/18639 0.0384615384615385 0.651713286713287 0.79457072527123 0.911600522016605 GO:0005160 transforming growth factor beta receptor binding 1/1100 26/18639 0.0384615384615385 0.651713286713287 0.79457072527123 0.911600522016605 GO:0008198 ferrous iron binding 1/1100 26/18639 0.0384615384615385 0.651713286713287 0.79457072527123 0.911600522016605 GO:0015145 monosaccharide transmembrane transporter activity 1/1100 26/18639 0.0384615384615385 0.651713286713287 0.79457072527123 0.911600522016605 GO:0016289 acyl-CoA hydrolase activity 1/1100 26/18639 0.0384615384615385 0.651713286713287 0.79457072527123 0.911600522016605 GO:0019865 immunoglobulin binding 1/1100 26/18639 0.0384615384615385 0.651713286713287 0.79457072527123 0.911600522016605 GO:0030247 polysaccharide binding 1/1100 26/18639 0.0384615384615385 0.651713286713287 0.79457072527123 0.911600522016605 GO:0052742 phosphatidylinositol kinase activity 1/1100 26/18639 0.0384615384615385 0.651713286713287 0.79457072527123 0.911600522016605 GO:0140299 molecular sensor activity 3/1100 71/18639 0.0422535211267606 0.715966709346991 0.79779250846157 0.914284334918348 GO:0042277 peptide binding 12/1100 249/18639 0.0481927710843374 0.816604600219058 0.804013269627626 0.91740163474706 GO:0001671 ATPase activator activity 1/1100 27/18639 0.037037037037037 0.627575757575757 0.806711283064259 0.91740163474706 GO:0004364 glutathione transferase activity 1/1100 27/18639 0.037037037037037 0.627575757575757 0.806711283064259 0.91740163474706 GO:0008320 protein transmembrane transporter activity 1/1100 27/18639 0.037037037037037 0.627575757575757 0.806711283064259 0.91740163474706 GO:0008395 steroid hydroxylase activity 1/1100 27/18639 0.037037037037037 0.627575757575757 0.806711283064259 0.91740163474706 GO:0015252 proton channel activity 1/1100 27/18639 0.037037037037037 0.627575757575757 0.806711283064259 0.91740163474706 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/1100 27/18639 0.037037037037037 0.627575757575757 0.806711283064259 0.91740163474706 GO:0016410 N-acyltransferase activity 4/1100 94/18639 0.0425531914893617 0.721044487427466 0.812859091788724 0.92236803843715 GO:0042562 hormone binding 4/1100 94/18639 0.0425531914893617 0.721044487427466 0.812859091788724 0.92236803843715 GO:0016866 intramolecular transferase activity 1/1100 28/18639 0.0357142857142857 0.605162337662338 0.818134966098286 0.923298284180637 GO:0045499 chemorepellent activity 1/1100 28/18639 0.0357142857142857 0.605162337662338 0.818134966098286 0.923298284180637 GO:0051019 mitogen-activated protein kinase binding 1/1100 28/18639 0.0357142857142857 0.605162337662338 0.818134966098286 0.923298284180637 GO:0051119 sugar transmembrane transporter activity 1/1100 28/18639 0.0357142857142857 0.605162337662338 0.818134966098286 0.923298284180637 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/1100 28/18639 0.0357142857142857 0.605162337662338 0.818134966098286 0.923298284180637 GO:0030159 signaling receptor complex adaptor activity 2/1100 52/18639 0.0384615384615385 0.651713286713287 0.820177225341338 0.924233896196669 GO:0140375 immune receptor activity 7/1100 156/18639 0.0448717948717949 0.760332167832168 0.820748247587775 0.924233896196669 GO:0008146 sulfotransferase activity 2/1100 53/18639 0.0377358490566038 0.639416809605489 0.82832011006716 0.929354864229597 GO:0034212 protein N-acetyltransferase activity 2/1100 53/18639 0.0377358490566038 0.639416809605489 0.82832011006716 0.929354864229597 GO:0004181 metallocarboxypeptidase activity 1/1100 29/18639 0.0344827586206897 0.584294670846395 0.828884068096668 0.929354864229597 GO:0004629 phospholipase C activity 1/1100 29/18639 0.0344827586206897 0.584294670846395 0.828884068096668 0.929354864229597 GO:0005319 lipid transporter activity 8/1100 178/18639 0.0449438202247191 0.761552604698672 0.831264792558937 0.93101656766601 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/1100 30/18639 0.0333333333333333 0.564818181818182 0.838998389702991 0.936640443677046 GO:0031624 ubiquitin conjugating enzyme binding 1/1100 30/18639 0.0333333333333333 0.564818181818182 0.838998389702991 0.936640443677046 GO:0051721 protein phosphatase 2A binding 1/1100 30/18639 0.0333333333333333 0.564818181818182 0.838998389702991 0.936640443677046 GO:0140097 catalytic activity, acting on DNA 16/1100 336/18639 0.0476190476190476 0.806883116883117 0.844689201602578 0.939168738445923 GO:0005184 neuropeptide hormone activity 1/1100 31/18639 0.032258064516129 0.546598240469208 0.848515385314077 0.939168738445923 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1100 31/18639 0.032258064516129 0.546598240469208 0.848515385314077 0.939168738445923 GO:0005452 solute:inorganic anion antiporter activity 1/1100 31/18639 0.032258064516129 0.546598240469208 0.848515385314077 0.939168738445923 GO:0008327 methyl-CpG binding 1/1100 31/18639 0.032258064516129 0.546598240469208 0.848515385314077 0.939168738445923 GO:0016411 acylglycerol O-acyltransferase activity 1/1100 31/18639 0.032258064516129 0.546598240469208 0.848515385314077 0.939168738445923 GO:0070273 phosphatidylinositol-4-phosphate binding 1/1100 31/18639 0.032258064516129 0.546598240469208 0.848515385314077 0.939168738445923 GO:0072349 modified amino acid transmembrane transporter activity 1/1100 31/18639 0.032258064516129 0.546598240469208 0.848515385314077 0.939168738445923 GO:0030170 pyridoxal phosphate binding 2/1100 56/18639 0.0357142857142857 0.605162337662338 0.850790297898154 0.940681695434886 GO:0015370 solute:sodium symporter activity 3/1100 79/18639 0.0379746835443038 0.643463751438435 0.85264229791455 0.941724329039951 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/1100 32/18639 0.03125 0.529517045454545 0.85747030127251 0.943247962953842 GO:0160041 neuropeptide activity 1/1100 32/18639 0.03125 0.529517045454545 0.85747030127251 0.943247962953842 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/1100 57/18639 0.0350877192982456 0.594545454545455 0.857663688322895 0.943247962953842 GO:0070279 vitamin B6 binding 2/1100 57/18639 0.0350877192982456 0.594545454545455 0.857663688322895 0.943247962953842 GO:0015171 amino acid transmembrane transporter activity 4/1100 102/18639 0.0392156862745098 0.664491978609626 0.859271783494337 0.944014387805019 GO:0008408 3'-5' exonuclease activity 2/1100 58/18639 0.0344827586206897 0.584294670846395 0.86424642047595 0.945977019906632 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/1100 33/18639 0.0303030303030303 0.513471074380165 0.865896305926685 0.945977019906632 GO:0019239 deaminase activity 1/1100 33/18639 0.0303030303030303 0.513471074380165 0.865896305926685 0.945977019906632 GO:0030296 protein tyrosine kinase activator activity 1/1100 33/18639 0.0303030303030303 0.513471074380165 0.865896305926685 0.945977019906632 GO:0046943 carboxylic acid transmembrane transporter activity 8/1100 188/18639 0.0425531914893617 0.721044487427466 0.871784541398241 0.945977019906632 GO:0008376 acetylgalactosaminyltransferase activity 1/1100 34/18639 0.0294117647058824 0.498368983957219 0.873824612036577 0.945977019906632 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/1100 34/18639 0.0294117647058824 0.498368983957219 0.873824612036577 0.945977019906632 GO:0030332 cyclin binding 1/1100 34/18639 0.0294117647058824 0.498368983957219 0.873824612036577 0.945977019906632 GO:0051427 hormone receptor binding 1/1100 34/18639 0.0294117647058824 0.498368983957219 0.873824612036577 0.945977019906632 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 10/1100 229/18639 0.0436681222707424 0.739936482731243 0.874691197295916 0.945977019906632 GO:0004518 nuclease activity 9/1100 209/18639 0.0430622009569378 0.729669421487603 0.874694281387794 0.945977019906632 GO:0005254 chloride channel activity 3/1100 83/18639 0.036144578313253 0.612453450164294 0.874849693318128 0.945977019906632 GO:0030165 PDZ domain binding 3/1100 83/18639 0.036144578313253 0.612453450164294 0.874849693318128 0.945977019906632 GO:0005342 organic acid transmembrane transporter activity 8/1100 189/18639 0.0423280423280423 0.717229437229437 0.875359360719481 0.945977019906632 GO:0004519 endonuclease activity 5/1100 127/18639 0.0393700787401575 0.667108088761632 0.876090519154487 0.945977019906632 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/1100 60/18639 0.0333333333333333 0.564818181818182 0.876581022307304 0.945977019906632 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1100 60/18639 0.0333333333333333 0.564818181818182 0.876581022307304 0.945977019906632 GO:0008509 monoatomic anion transmembrane transporter activity 6/1100 149/18639 0.0402684563758389 0.682330689444783 0.879727405400758 0.947602485136649 GO:0004527 exonuclease activity 3/1100 84/18639 0.0357142857142857 0.605162337662338 0.879916593341174 0.947602485136649 GO:0016229 steroid dehydrogenase activity 1/1100 35/18639 0.0285714285714286 0.48412987012987 0.88128459197529 0.948090173713812 GO:0015026 coreceptor activity 2/1100 61/18639 0.0327868852459016 0.555558867362146 0.88235292229906 0.948254800313098 GO:0016298 lipase activity 5/1100 130/18639 0.0384615384615385 0.651713286713287 0.888222124686181 0.949724278690866 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/1100 130/18639 0.0384615384615385 0.651713286713287 0.888222124686181 0.949724278690866 GO:0004033 aldo-keto reductase (NADPH) activity 1/1100 36/18639 0.0277777777777778 0.470681818181818 0.888303886150048 0.949724278690866 GO:0004190 aspartic-type endopeptidase activity 1/1100 36/18639 0.0277777777777778 0.470681818181818 0.888303886150048 0.949724278690866 GO:0005484 SNAP receptor activity 1/1100 36/18639 0.0277777777777778 0.470681818181818 0.888303886150048 0.949724278690866 GO:0030280 structural constituent of skin epidermis 1/1100 37/18639 0.027027027027027 0.457960687960688 0.894908505041353 0.953832521834199 GO:0043394 proteoglycan binding 1/1100 37/18639 0.027027027027027 0.457960687960688 0.894908505041353 0.953832521834199 GO:0070001 aspartic-type peptidase activity 1/1100 37/18639 0.027027027027027 0.457960687960688 0.894908505041353 0.953832521834199 GO:0005109 frizzled binding 1/1100 38/18639 0.0263157894736842 0.445909090909091 0.90112292523566 0.959469013919984 GO:0120013 lipid transfer activity 2/1100 65/18639 0.0307692307692308 0.521370629370629 0.903027571969483 0.960509819877191 GO:0015144 carbohydrate transmembrane transporter activity 1/1100 40/18639 0.025 0.423613636363636 0.912471943364742 0.96918889582006 GO:0043178 alcohol binding 3/1100 92/18639 0.0326086956521739 0.5525395256917 0.914287331171727 0.96918889582006 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 7/1100 181/18639 0.0386740331491713 0.65531391260673 0.914990111474756 0.96918889582006 GO:0140223 general transcription initiation factor activity 2/1100 68/18639 0.0294117647058824 0.498368983957219 0.916250731017307 0.96918889582006 GO:0008227 G protein-coupled amine receptor activity 1/1100 41/18639 0.024390243902439 0.413281596452328 0.917648612126438 0.96918889582006 GO:0140318 protein transporter activity 1/1100 41/18639 0.024390243902439 0.413281596452328 0.917648612126438 0.96918889582006 GO:0051213 dioxygenase activity 3/1100 93/18639 0.032258064516129 0.546598240469208 0.917888375114651 0.96918889582006 GO:0070851 growth factor receptor binding 5/1100 139/18639 0.0359712230215827 0.609516023544801 0.918671327891215 0.96918889582006 GO:0004520 DNA endonuclease activity 1/1100 42/18639 0.0238095238095238 0.403441558441558 0.922519379233703 0.972258470891268 GO:0008276 protein methyltransferase activity 3/1100 95/18639 0.0315789473684211 0.535090909090909 0.924679383132389 0.973544553785727 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1100 43/18639 0.0232558139534884 0.394059196617336 0.927102305665005 0.974930984254794 GO:0016407 acetyltransferase activity 3/1100 96/18639 0.03125 0.529517045454545 0.927878330574543 0.974930984254794 GO:0015103 inorganic anion transmembrane transporter activity 6/1100 165/18639 0.0363636363636364 0.616165289256198 0.929242587817817 0.975375198560546 GO:0030547 signaling receptor inhibitor activity 1/1100 44/18639 0.0227272727272727 0.385103305785124 0.931414386960364 0.976095831552991 GO:0015108 chloride transmembrane transporter activity 4/1100 121/18639 0.0330578512396694 0.56015026296018 0.931813491704544 0.976095831552991 GO:0042626 ATPase-coupled transmembrane transporter activity 3/1100 98/18639 0.0306122448979592 0.518710575139147 0.933904830061862 0.976964308664906 GO:0008194 UDP-glycosyltransferase activity 5/1100 145/18639 0.0344827586206897 0.584294670846395 0.934663723841166 0.976964308664906 GO:0140303 intramembrane lipid transporter activity 1/1100 45/18639 0.0222222222222222 0.376545454545455 0.935471616018906 0.976964308664906 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1100 46/18639 0.0217391304347826 0.368359683794466 0.939289042198276 0.979963190047748 GO:0005504 fatty acid binding 1/1100 47/18639 0.0212765957446809 0.360522243713733 0.942880826933494 0.982720861874345 GO:0008188 neuropeptide receptor activity 1/1100 48/18639 0.0208333333333333 0.353011363636364 0.946260296080071 0.985251926370807 GO:0003823 antigen binding 6/1100 174/18639 0.0344827586206897 0.584294670846395 0.948332512764327 0.986418155847232 GO:0033293 monocarboxylic acid binding 2/1100 79/18639 0.0253164556962025 0.42897583429229 0.951588445377016 0.987978961705387 GO:0015605 organophosphate ester transmembrane transporter activity 1/1100 50/18639 0.02 0.338890909090909 0.952431705791059 0.987978961705387 GO:0004497 monooxygenase activity 3/1100 106/18639 0.0283018867924528 0.479562607204117 0.953647646433772 0.987978961705387 GO:0008013 beta-catenin binding 3/1100 106/18639 0.0283018867924528 0.479562607204117 0.953647646433772 0.987978961705387 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/1100 52/18639 0.0192307692307692 0.325856643356643 0.957894967287507 0.991387798311546 GO:0008514 organic anion transmembrane transporter activity 10/1100 269/18639 0.0371747211895911 0.62990875295708 0.959573350697687 0.991984761672537 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/1100 53/18639 0.0188679245283019 0.319708404802744 0.960386791464821 0.991984761672537 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/1100 54/18639 0.0185185185185185 0.313787878787879 0.962731272761964 0.992702556245168 GO:0016779 nucleotidyltransferase activity 4/1100 136/18639 0.0294117647058824 0.498368983957219 0.962998136125863 0.992702556245168 GO:0004175 endopeptidase activity 16/1100 405/18639 0.0395061728395062 0.669414141414141 0.969438837306134 0.998348544184051 GO:0015294 solute:monoatomic cation symporter activity 3/1100 116/18639 0.0258620689655172 0.438221003134796 0.970600453443234 0.998552204336833 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/1100 91/18639 0.021978021978022 0.372407592407592 0.973792464822312 0.999999996653306 GO:0015293 symporter activity 4/1100 146/18639 0.0273972602739726 0.464234122042341 0.975772825306267 0.999999996653306 GO:0008528 G protein-coupled peptide receptor activity 3/1100 122/18639 0.0245901639344262 0.41666915052161 0.977752568972748 0.999999996653306 GO:0016758 hexosyltransferase activity 6/1100 197/18639 0.0304568527918782 0.516077526534379 0.977893467397501 0.999999996653306 GO:0016757 glycosyltransferase activity 9/1100 267/18639 0.0337078651685393 0.571164453524004 0.978655724074785 0.999999996653306 GO:0004536 DNA nuclease activity 1/1100 64/18639 0.015625 0.264758522727273 0.979755404881519 0.999999996653306 GO:0001653 peptide receptor activity 3/1100 128/18639 0.0234375 0.397137784090909 0.983228219585854 0.999999996653306 GO:0005548 phospholipid transporter activity 1/1100 68/18639 0.0147058823529412 0.24918449197861 0.984141806532148 0.999999996653306 GO:0005262 calcium channel activity 3/1100 131/18639 0.0229007633587786 0.388043025676613 0.98545701888645 0.999999996653306 GO:0015297 antiporter activity 3/1100 135/18639 0.0222222222222222 0.376545454545455 0.987990595723172 0.999999996653306 GO:0015085 calcium ion transmembrane transporter activity 3/1100 147/18639 0.0204081632653061 0.345807050092764 0.993292765438117 0.999999996653306 GO:0015291 secondary active transmembrane transporter activity 8/1100 287/18639 0.0278745644599303 0.472321824516946 0.995561273852128 0.999999996653306 GO:0015081 sodium ion transmembrane transporter activity 3/1100 164/18639 0.0182926829268293 0.309961197339246 0.997115623679809 0.999999996653306 GO:0005249 voltage-gated potassium channel activity 1/1100 98/18639 0.0102040816326531 0.172903525046382 0.99746436503571 0.999999996653306 GO:0046873 metal ion transmembrane transporter activity 14/1100 450/18639 0.0311111111111111 0.527163636363636 0.997936135746524 0.999999996653306 GO:0045182 translation regulator activity 10/1100 356/18639 0.0280898876404494 0.47597037793667 0.997956591922281 0.999999996653306 GO:0004252 serine-type endopeptidase activity 3/1100 176/18639 0.0170454545454545 0.288827479338843 0.99842812228645 0.999999996653306 GO:0000149 SNARE binding 1/1100 106/18639 0.00943396226415094 0.159854202401372 0.998445641541415 0.999999996653306 GO:0008236 serine-type peptidase activity 3/1100 194/18639 0.0154639175257732 0.262029053420806 0.999377100379239 0.999999996653306 GO:0005267 potassium channel activity 1/1100 124/18639 0.00806451612903226 0.136649560117302 0.999483583531781 0.999999996653306 GO:0017171 serine hydrolase activity 3/1100 198/18639 0.0151515151515152 0.256735537190083 0.999494031072659 0.999999996653306 GO:0022843 voltage-gated monoatomic cation channel activity 1/1100 143/18639 0.00699300699300699 0.118493324856961 0.99983880853522 0.999999996653306 GO:0005216 monoatomic ion channel activity 11/1100 448/18639 0.0245535714285714 0.416049107142857 0.999851309320274 0.999999996653306 GO:0015079 potassium ion transmembrane transporter activity 1/1100 160/18639 0.00625 0.105903409090909 0.999943185800517 0.999999996653306 GO:0005244 voltage-gated monoatomic ion channel activity 1/1100 173/18639 0.00578034682080925 0.0979453494482396 0.999974423392482 0.999999996653306 GO:0022832 voltage-gated channel activity 1/1100 175/18639 0.00571428571428571 0.096825974025974 0.999977379855223 0.999999996653306 GO:0030371 translation repressor activity 5/1100 329/18639 0.0151975683890578 0.257515888366952 0.999983533255738 0.999999996653306 GO:0005261 monoatomic cation channel activity 5/1100 341/18639 0.0146627565982405 0.248453745667822 0.999991003851369 0.999999996653306 GO:0022836 gated channel activity 1/1100 318/18639 0.00314465408805031 0.0532847341337907 0.999999996653306 0.999999996653306