category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	126/1076	222/9376	4.94564452928765	RPS2/RPL29/RPS18/RPS24/RPS23/RPL26/RPL13A/RPS7/RPS4X/RPS11/RPS3A/RPL11/RPS19/RPS6/RPL7A/RPL18A/RPS15/RPS12/RPL32/RPL6/RPL18/RPLP0/RPL27A/RPS27A/RPS3/RPL23A/RPL13/RPL10A/UBA52/RPS14/RPS16/RPS20/RPS5/RPL8/RPL23/RPSA/RPL14/RPL30/RPS13/RPL5/RPL28/RPL10/RPL15/RPLP1/RPL3/RPL24/RPL21/RPS15A/RPL36/RPL37A/RPL12/RPL19/RPS8/RPL9/RPS9/RPL22/RPS27/RPLP2/RPL34/RPL7/RPL37/RPL35A/RPS28/RPS25/RPL35/RPS29/RPL38/RPL27/RPL31/RPS10/RPL4/FAU/RPS26/MRPS14/MRPL19/MRPL46/MRPL3/RPS21/MRPL32/RPL39/RPL41/MRPS22/RPS4Y1/MRPS23/MRPL50/MRPS28/MRPS26/MRPS11/MRPL42/MRPL34/DAP3/MRPL4/RSL24D1/MRPS7/MRPL2/MRPS31/MRPL44/MRPL40/MRPS30/MRPS5/MRPS25/MRPS9/MRPL21/MRPL35/MRPL37/MRPL24/MRPL10/MRPL36/MRPL9/MRPL17/MRPL1/MRPS27/MRPL22/MRPL52/MRPL28/MRPL45/MRPL23/MRPL39/MRPL55/MRPL16/MRPL15/MRPS16/MRPL13/MRPS6/RPL36A/MRPL48	21.4210974589086
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	90/1076	238/9376	3.29511730342695	RPS2/RPL29/RPS18/RPS24/RPS23/RPL26/RPL13A/RPS7/RPS4X/RPS11/RPS3A/RPL11/RPS19/RPS6/RPL7A/RPL18A/RPS15/RPS12/RPL32/RPL6/RPL18/RPLP0/RPL27A/RPS27A/RPS3/RPL23A/RPL13/RPL10A/UBA52/RPS14/RPS16/RPS20/RPS5/RPL8/RPL23/RPSA/RPL14/RPL30/RPS13/RPL5/RPL28/RPL10/RPL15/RPLP1/RPL3/RPL24/RPL21/RPS15A/RPL36/RPL37A/RPL12/RPL19/RPS8/RPL9/RPS9/RPL22/RPS27/RPLP2/RPL34/RPL7/RPL37/RPL35A/RPS28/RPS25/RPL35/RPS29/RPL38/RPL27/RPL31/RPS10/RPL4/FAU/RPS26/RPS21/RPL39/RPL41/RPS4Y1/MAPK13/IRAK1/RSL24D1/MAPK8/CHUK/TBK1/PIK3CB/MAPK9/IRF3/NFKBIB/MAPK3/TRAF3/RPL36A	12.9128027374578
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	75/1076	268/9376	2.43855074072019	RPS27A/UBA52/CALM1/TUBA1B/UQCRH/TUBA1C/SLC25A5/TUBB/COX4I1/PSMA7/GNAS/UQCRC2/SDHB/UQCR10/NDUFV3/EIF2S1/CYC1/PSMC6/SDHA/NDUFA9/UBB/COX5B/NDUFB5/PRKACB/UBE2J1/UBE2J2/PSMD9/KIF5B/NDUFS8/COX5A/NDUFS5/COX6C/NDUFS3/NDUFS2/MAPK8/NDUFA8/CASP3/PSMD12/NDUFB9/NDUFA10/PSMD2/SLC39A4/PSMD1/PSMD6/PSMC2/NDUFB2/COX7C/TUBA4A/VDAC3/MAPK9/GNAI3/TUBB6/PSMD3/HTRA2/NDUFS7/UQCRB/PARK7/PRKACA/UQCRC1/NDUFB6/TXN/PSMD13/NDUFA13/KLC2/NDUFB1/PSMA3/COX7A2L/ATF4/BAX/NDUFA4/MT-ND4/PSMD14/TRAP1/PSMD8/PSMD11	8.602680599371
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	78/1076	308/9376	2.20673007290108	TUBA1B/UQCRH/TUBA1C/SLC25A5/TUBB/COX4I1/PSMA7/ACTR10/UQCRC2/SDHB/UQCR10/NDUFV3/POLR2C/CYC1/PSMC6/SDHA/NDUFA9/HDAC1/COX5B/NDUFB5/PSMD9/KIF5B/NDUFS8/DCTN2/POLR2E/POLR2K/COX5A/NDUFS5/COX6C/ATG13/NDUFS3/NDUFS2/MAPK8/NDUFA8/CASP3/PSMD12/NDUFB9/NDUFA10/PSMD2/PSMD1/GNAQ/PSMD6/PSMC2/NDUFB2/COX7C/HTT/TUBA4A/VDAC3/MAPK9/RCOR1/TUBB6/PSMD3/NDUFS7/CLTA/UQCRB/DCTN5/UQCRC1/PIK3R4/NDUFB6/PSMD13/AP2M1/NDUFA13/KLC2/POLR2D/NDUFB1/PSMA3/TFAM/COX7A2L/TBP/TBPL1/BAX/HAP1/NDUFA4/MT-ND4/MAP2K7/PSMD14/PSMD8/PSMD11	7.75322640421161
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	87/1076	368/9376	2.06004525618232	TUBA1B/UQCRH/HNRNPA1/TUBA1C/TUBB/PFN1/COX4I1/PSMA7/ACTB/ACTR10/UQCRC2/RAB8A/SDHB/UQCR10/NDUFV3/EIF2S1/CYC1/PSMC6/SDHA/NDUFA9/COX5B/NDUFB5/CCS/MAPK13/PSMD9/KIF5B/NDUFS8/DCTN2/COX5A/NDUFS5/COX6C/ATG13/NDUFS3/NDUFS2/RAE1/NDUFA8/CASP3/PSMD12/NDUFB9/SEC13/NDUFA10/NUP62/PSMD2/UBQLN2/PSMD1/VCP/PSMD6/PSMC2/FUS/NDUFB2/COX7C/POM121/NUP54/TARDBP/TUBA4A/TBK1/ACTG1/NXT1/SRSF7/TNFRSF1B/TUBB6/PSMD3/NDUFS7/NUP35/BAD/UQCRB/DCTN5/UQCRC1/PIK3R4/NDUFB6/PSMD13/NDUFA13/KLC2/NDUFB1/PSMA3/TOMM40/NUP85/COX7A2L/ATF4/BAX/HAP1/NDUFA4/PPP3R1/MT-ND4/PSMD14/PSMD8/PSMD11	7.46941956890584
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	71/1076	275/9376	2.24973301791146	TUBA1B/UQCRH/TUBA1C/SLC25A5/TUBB/COX4I1/PSMA7/UQCRC2/SDHB/UQCR10/NDUFV3/EIF2S1/CYC1/PSMC6/SDHA/NDUFA9/COX5B/NDUFB5/PRKACB/MAPK13/PSMD9/KIF5B/NDUFS8/COX5A/NDUFS5/COX6C/NDUFS3/NDUFS2/MAPK8/NDUFA8/CASP3/PSMD12/NDUFB9/NDUFA10/PSMD2/PSMD1/PSMD6/PSMC2/NDUFB2/COX7C/CSNK2B/GSK3B/TUBA4A/STIP1/PIK3CB/VDAC3/MAPK9/TUBB6/PSMD3/NDUFS7/BAD/UQCRB/PRKACA/UQCRC1/NDUFB6/PSMD13/NDUFA13/KLC2/NDUFB1/PSMA3/CSNK2A2/COX7A2L/MAPK3/ATF4/BAX/NDUFA4/PPP3R1/MT-ND4/PSMD14/PSMD8/PSMD11	7.57341510364776
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	46/1076	142/9376	2.82276558982146	RPS27A/UBA52/CDC26/UBE2C/UBE2E3/ANAPC13/CDC34/UBB/SKP2/UBE2J1/UBE2J2/ANAPC11/CDC20/CDC23/UBE2E1/ANAPC16/ANAPC5/FBXW7/CUL4B/UBE2F/FZR1/ANAPC15/UBE2D4/CUL1/PRPF19/SAE1/UBE2M/TRIM37/UBE2A/VHL/DDB1/SIAH1/UBE2I/UBA2/UBE2S/UBE3C/FBXO4/UBE2H/MDM2/PIAS4/CUL4A/UBE2K/CBL/ANAPC10/MGRN1/WWP2	7.88011918484254
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	60/1076	235/9376	2.22478842046982	RPS6/UQCRH/COX4I1/GNAS/ACTB/UQCRC2/SDHB/UQCR10/NDUFV3/CYC1/SDHA/NDUFA9/SMARCE1/COA1/COX5B/NDUFB5/PRKACB/MAPK13/NDUFS8/NDUFAF3/COX5A/NDUFS5/COX6C/NDUFS3/NDUFS2/SMARCB1/NDUFA8/NDUFB9/NDUFA10/NDUFAF7/NDUFB2/ARID1A/COX7C/MLST8/ACTG1/RPS6KB2/KDM1A/ACTL6A/RPS6KB1/COX19/NDUFS7/SMARCA2/UQCRB/COX16/PRKACA/PRKAB2/COX14/AKT1S1/COX10/UQCRC1/SIRT6/SMARCD2/NDUFB6/NDUFAF4/NDUFA13/NDUFB1/COX7A2L/NDUFAF5/NDUFA4/MT-ND4	6.84622039764994
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	99/1076	480/9376	1.79721189591078	RPS27A/UBA52/CALM1/TUBA1B/UQCRH/TUBA1C/SLC25A5/TUBB/COX4I1/PSMA7/ACTR10/UQCRC2/RAB8A/SDHB/UQCR10/NDUFV3/EIF2S1/CYC1/PSMC6/SDHA/CAPN1/NDUFA9/UBB/COX5B/NDUFB5/UBE2J1/CCS/UBE2J2/MAPK13/PSMD9/KIF5B/NDUFS8/DCTN2/PPID/COX5A/NDUFS5/COX6C/ATG13/NDUFS3/NDUFS2/MAPK8/NDUFA8/CASP3/PSMD12/NDUFB9/NDUFA10/PSMD2/PSMD1/GNAQ/VCP/PSMD6/PSMC2/FUS/NDUFB2/COX7C/CSNK2B/HTT/TARDBP/GSK3B/TUBA4A/TBK1/VDAC3/MAPK9/CDK5/TNFRSF1B/TUBB6/PSMD3/MAP2K2/HTRA2/NDUFS7/BAD/UQCRB/PARK7/DCTN5/DVL3/UQCRC1/PIK3R4/NDUFB6/PSMD13/NDUFA13/KLC2/NDUFB1/PSMA3/CSNK2A2/TOMM40/FRAT2/COX7A2L/MAPK3/ATF4/BAX/HAP1/NDUFA4/PPP3R1/MT-ND4/MAP2K7/PSMD14/TRAP1/PSMD8/PSMD11	6.4557949799796
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	45/1076	157/9376	2.49757298794781	UQCRH/LEP/COX4I1/UQCRC2/SDHB/UQCR10/NDUFV3/EIF2S1/CYC1/SDHA/NDUFA9/COX5B/NDUFB5/MAPK13/NDUFS8/COX5A/NDUFS5/COX6C/NDUFS3/GSK3A/NDUFS2/MAPK8/NDUFA8/CASP3/NDUFB9/NDUFA10/AKT2/NDUFB2/COX7C/GSK3B/PIK3CB/MAPK9/NDUFS7/UQCRB/PRKAB2/UQCRC1/CDC42/NDUFB6/NDUFA13/NDUFB1/COX7A2L/ATF4/AKT1/BAX/NDUFA4	6.81316088446209
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	83/1076	388/9376	1.86402483424673	GAPDH/CALM1/TUBA1B/UQCRH/TUBA1C/SLC25A5/TUBB/COX4I1/PSMA7/UQCRC2/SDHB/UQCR10/NDUFV3/EIF2S1/CYC1/PSMC6/SDHA/NAE1/CAPN1/NDUFA9/COX5B/NDUFB5/PSMD9/KIF5B/NDUFS8/PPID/COX5A/NDUFS5/COX6C/ATG13/NDUFS3/NDUFS2/MAPK8/NDUFA8/CASP3/PSMD12/NDUFB9/NDUFA10/CHUK/PSMD2/SLC39A4/PSMD1/GNAQ/PSMD6/AKT2/PSMC2/NDUFB2/COX7C/CSNK2B/GSK3B/TUBA4A/PIK3CB/VDAC3/MAPK9/CDK5/TUBB6/PSMD3/MAP2K2/NDUFS7/BAD/UQCRB/DVL3/UQCRC1/PIK3R4/NDUFB6/PSMD13/NDUFA13/KLC2/NDUFB1/PSMA3/CSNK2A2/FRAT2/COX7A2L/MAPK3/ATF4/AKT1/NDUFA4/PPP3R1/MT-ND4/MAP2K7/PSMD14/PSMD8/PSMD11	6.25839952065716
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	50/1076	205/9376	2.12530601142443	GAPDH/UQCRH/SLC25A5/COX4I1/COL3A1/COL1A2/UQCRC2/COL1A1/SDHB/UQCR10/NDUFV3/CYC1/SDHA/NDUFA9/COX5B/NDUFB5/MAPK13/NDUFS8/MMP2/COX5A/NDUFS5/COX6C/NDUFS3/PDHB/NDUFS2/MAPK8/NDUFA8/PDHA1/NDUFB9/NDUFA10/AKT2/PDK2/NDUFB2/COX7C/GSK3B/PIK3CB/VDAC3/MAPK9/NDUFS7/UQCRB/UQCRC1/NDUFB6/NDUFA13/NDUFB1/PTEN/G6PD/COX7A2L/AKT1/NDUFA4/MT-ND4	5.86532322844353
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	38/1076	138/9376	2.39943968536178	UQCRH/COX4I1/PPA2/ATP6V0D1/UQCRC2/SDHB/UQCR10/NDUFV3/CYC1/SDHA/NDUFA9/ATP6V1E1/COX5B/NDUFB5/ATP6V1A/NDUFS8/COX5A/NDUFS5/COX6C/NDUFS3/NDUFS2/NDUFA8/NDUFB9/NDUFA10/NDUFB2/COX7C/LHPP/NDUFS7/UQCRB/COX10/UQCRC1/ATP6V1B1/NDUFB6/NDUFA13/NDUFB1/COX7A2L/NDUFA4/MT-ND4	5.96289933108971
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	32/1076	108/9376	2.58185322869338	RAN/PNN/RNPS1/SUMO1/EIF4A3/RAE1/NCBP2/SEC13/NUP62/KPNB1/UPF1/EEF1A1/TNPO1/SNUPN/POM121/RBM8A/NUP54/UPF3A/IPO5/NXT1/MAGOHB/SAP18/IPO7/UBE2I/SENP2/NUP35/SUMO3/NUP85/IPO8/IPO9/AAAS/XPO7	5.95302598341194
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	53/1076	227/9376	2.03448897040761	UQCRH/MGST3/SLC25A5/COX4I1/UQCRC2/SDHB/UQCR10/NDUFV3/CYC1/SDHA/NDUFA9/PTK2/COX5B/CBR1/NDUFB5/MAPK13/NDUFS8/COX5A/NDUFS5/COX6C/NDUFS3/NDUFS2/MAPK8/GSTA4/NDUFA8/NDUFB9/NDUFA10/CHUK/AKT2/NDUFB2/AKR1A1/COX7C/ARNT/PIK3CB/GSTO1/VDAC3/MAPK9/NQO1/MAP2K2/NDUFS7/BAD/UQCRB/UQCRC1/NDUFB6/NDUFA13/NDUFB1/PTEN/COX7A2L/MAPK3/AKT1/NDUFA4/MT-ND4/MAP2K7	5.6807373115137
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	14/1076	30/9376	4.06641883519207	SDHB/SDHA/DLD/SUCLG2/PDHB/ACLY/PDHA1/IDH3B/CS/SUCLG1/ACO1/MDH1/IDH1/PCK2	6.05664251187221
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	55/1076	253/9376	1.89429448844351	RPS27A/UBA52/PFN1/ACTB/SHARPIN/CAPN1/UBB/PTK2/BCL10/RPS6KA5/MAPK13/PPID/TNIP1/GSK3A/ATG12/ILK/FNBP1/MAPK8/ARPC5L/CHUK/AKT2/TLN2/CASP4/UBE2D4/GSK3B/CUL1/RRAGC/TBK1/PIK3CB/ACTG1/RBCK1/RPS6KB2/FOXO1/MAPK9/IRF3/HK1/CRK/ARPC5/UBE2V1/RPS6KB1/MDM2/AKT1S1/WASF2/DOCK1/NFKBIB/CDC42/PIK3R4/ARPC1A/PYCARD/ARPC2/MAPK3/ARPC3/AKT1/BAX/BNIP3	5.19188070501591
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	17/1076	46/9376	3.22030063035397	PSMA7/PSMC6/PSMD9/PSMD12/PSMD2/PSMD1/PSMD6/PSMC2/PSME3/PSMD3/PSMD13/PSMA3/POMP/PSME1/PSMD14/PSMD8/PSMD11	5.43503823771136
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	39/1076	169/9376	2.01086645696311	RPS27A/UBA52/HMGB1/RAB8A/EIF2S1/UBB/RAB7A/ATG3/WDR45B/PRKACB/ATG13/ATG4B/ATG12/MAPK8/AKT2/DAPK3/ATG4A/ATG10/MLST8/RRAGC/TBK1/PIK3CB/SNAP29/RPS6KB2/MAPK9/ATG4C/RPS6KB1/MAP2K2/BAD/UVRAG/PRKACA/AKT1S1/YKT6/STK11/PIK3R4/PTEN/MAPK3/AKT1/BNIP3	4.77453184394246
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	36/1076	158/9376	1.98541245117877	CDKN1C/CCNE1/CCNB1/CDC26/ANAPC13/HDAC1/SKP2/PRKDC/CDK1/PTTG1/ANAPC11/CDC20/CDC23/BUB3/ORC4/CCNB2/ANAPC16/ANAPC5/YWHAQ/PPP2R1A/PPP2R5E/FZR1/ANAPC15/GSK3B/CUL1/RAD21/CCNA2/CDT1/PPP2R5C/MDM2/ORC5/AURKB/WEE1/ANAPC10/CDK4/ZBTB17	4.497601413588
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/1076	248/9376	1.7568053723468	GAPDH/RPS3/TUBA1B/TUBA1C/TUBB/PFN1/HSP90AA1/ACTB/ANXA2/DYNLL1/ACTR10/RALA/GSDMD/RAB7A/DYNC1LI2/MAPK13/KIF5B/PKN1/DCTN2/IRAK1/MAPK8/EXOC5/RILP/CASP3/ARPC5L/CHUK/FBXO22/PAK1/AKT2/CASP4/TUBA4A/PIK3CB/ACTG1/MAPK9/ARPC5/TUBB6/HSP90AB1/MAP2K2/DCTN5/CDC42/TXN/ARPC1A/KLC2/PYCARD/ARPC2/MAPK3/ARPC3/AKT1/BAX/MAP2K7	4.34885531152967
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	15/1076	44/9376	2.97059817505914	GTF2F2/TAF10/MNAT1/GTF2F1/GTF2B/GTF2H3/GTF2A2/TAF12/TAF11/TAF15/TAF6/TAF9/TAF13/TBP/TBPL1	4.71725960155965
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	26/1076	103/9376	2.19958855162955	ETF1/PNN/PABPN1/RNPS1/NUDT21/PELO/CPSF6/PPP2R2A/EIF4A3/FIP1L1/SSU72/NCBP2/PPP2R1A/PPP2R5E/UPF1/FUS/RBM8A/TARDBP/UPF3A/CPSF2/NXT1/MAGOHB/SAP18/PPP2R5C/CSTF2T/PPP2R3B	4.40751219411468
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	44/1076	214/9376	1.79161310495779	CALM1/HLA-G/CCNB1/GNB2/GNB5/PTK2/AP1S1/CDK1/MAPK13/IRAK1/GNB1/CCNB2/MAPK8/CASP3/CHUK/GNAQ/CFL1/CFL2/PAK1/AKT2/CUL4B/APOBEC3C/AP1M1/CUL1/TBK1/PIK3CB/RPS6KB2/MAPK9/IRF3/DDB1/CRK/GNAI3/RPS6KB1/TNFRSF1B/MAP2K2/BAD/CUL4A/AP1B1/MAPK3/WEE1/AKT1/BAX/PPP3R1/MAP2K7	4.21771709453222
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	28/1076	116/9376	2.10332008716831	GAPDH/TPI1/SDHB/ALDOA/HIBCH/SDHA/DLD/SUCLG2/SDSL/PDHB/PDHA1/IDH3B/CS/SUCLG1/ACO1/ESD/GPT2/PKM/PFKL/MDH1/HK1/GCSH/PCCB/PGD/IDH1/G6PD/ENO1/AMT	4.30504558073047
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	28/1076	117/9376	2.08534299240619	ACTB/CHRAC1/HDAC1/SMARCE1/PHF6/YY1/KAT5/TFPT/BCL7C/MCRS1/MTA3/SMARCB1/BAZ1A/ARID1A/UCHL5/INO80B/ACTG1/BRD9/ACTL6A/VPS72/SMARCA2/YEATS4/MRGBP/ZNHIT1/SMARCD2/GATAD2A/MBD3/DMAP1	4.25334511884244
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	45/1076	224/9376	1.75053106744557	HLA-G/CCNE1/SLC25A5/RAN/CDC26/ANAPC13/ETS2/PRKACB/MSX1/PTTG1/ANAPC11/CDC20/CDC23/KAT5/BUB3/CCNB2/ANAPC16/ANAPC5/MAPK8/CHUK/MSX2/RANBP1/AKT2/POLB/TLN2/FDPS/ANAPC15/NFYB/PIK3CB/VDAC3/MAPK9/RANBP3/CCNA2/MAP2K2/PRKACA/PTEN/MAPK3/ATF4/ANAPC10/TBP/TBPL1/AKT1/BAX/CDK4/PPP3R1	4.09343034997429
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	31/1076	138/9376	1.95743763805829	ACTB/PTK2/MAPK13/PKN1/IRAK1/MAPK8/ARPC5L/CHUK/GNAQ/AKT2/GSK3B/TBK1/PIK3CB/ACTG1/MAPK9/IRF3/CRK/ARPC5/PIP5K1C/MAP2K2/TICAM1/WASF2/DOCK1/CDC42/ARPC1A/PYCARD/ARPC2/MAPK3/ARPC3/AKT1/MAP2K7	4.07956435082946
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	26/1076	110/9376	2.05961473470767	CCNB1/HSP90AA1/CDC26/KIF22/ANAPC13/PRKACB/CDK1/MAPK13/ANAPC11/CDC23/CCNB2/ANAPC16/ANAPC5/MAPK8/AKT2/FZR1/ANAPC15/PIK3CB/MAPK9/CCNA2/GNAI3/HSP90AB1/PRKACA/MAPK3/ANAPC10/AKT1	4.02486122908399
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	12/1076	34/9376	3.07544281653182	POLR2C/POLR2M/POLR2E/POLR3D/POLR2K/POLR3K/POLR3GL/POLR3C/POLR1C/POLR1E/POLR2D/POLR3H	4.36498772496396
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	33/1076	154/9376	1.8672331386086	AK3/DLD/UGT2B7/MAT2A/PDXK/MOCS2/PPCS/MMAB/GMPPA/NADK/ALAS2/OXSM/SPR/GGH/MPI/GSS/AKR1A1/AK2/PPCDC/NME4/AK1/PMM1/NQO1/UMPS/GGCX/COX10/COQ6/PPOX/PHOSPHO2/NFS1/ALAD/PANK3/UROD	3.90693687101529
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	25/1076	105/9376	2.07470348734289	RPS27A/UBA52/EIF2S1/UBB/RAB7A/USP15/MON1B/MTX2/MAPK8/VCP/ARIH1/CSNK2B/SAMM50/TBK1/MAPK9/SIAH1/MTX1/BCL2L13/FKBP8/CSNK2A2/TOMM40/RHOT1/TFE3/ATF4/BNIP3	3.9872433721894
Genetic Information Processing	Transcription	hsa03040	Spliceosome	46/1076	243/9376	1.6495173405541	HNRNPA1/RBM22/SNW1/CCDC12/SNRPD2/SMNDC1/SF3A3/PLRG1/PPIE/PRPF31/BCAS2/PRPF40A/ISY1/PRPF4/ZMAT2/EIF4A3/RBM17/PQBP1/CWC15/NCBP2/RBMX2/SNRNP70/BUD31/PUF60/SNRNP200/FUS/RBM8A/SRSF2/SNRPD1/RBMX/TXNL4A/SNRPA1/HNRNPU/PRPF19/MAGOHB/PRPF38A/SRSF7/TCERG1/SNRPA/SRSF6/SNIP1/PCBP1/RP9/PRPF40B/RBMXL1/SF3B3	3.6935151593017
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	32/1076	158/9376	1.76481106771446	RPS6/SKP2/SLC3A2/ATP6V1E1/ATP6V1A/CAB39/SEC13/CHUK/EIF4EBP1/LAMTOR1/WDR59/AKT2/STRADB/MLST8/GSK3B/RRAGC/PIK3CB/RPS6KB2/FNIP2/RPS6KB1/MAP2K2/AKT1S1/DVL3/STK11/ATP6V1B1/EIF4E/TELO2/LAMTOR4/PTEN/MAPK3/NPRL2/AKT1	3.49073663029683
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	19/1076	78/9376	2.12258126012773	EXOSC1/HSPA9/EXOSC7/EXOSC6/EXOSC9/EXOSC4/CNOT1/DHX36/EXOSC3/BTG3/NUDT16/CNOT8/MPHOSPH6/PFKL/CNOT3/EXOSC8/CNOT6/ENO1/EXOSC10	3.58445428682831
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	19/1076	78/9376	2.12258126012773	ACTB/PTK2/SHC1/ILK/ARPC5L/PIK3CB/ACTG1/CRK/ARPC5/GAB1/CLTA/WASF2/DOCK1/CDC42/ARPC1A/ELMO3/ARPC2/ARPC3/CBL	3.58445428682831
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	29/1076	144/9376	1.75485336637753	SLC25A5/PSMA7/ATXN10/PSMC6/PSMD9/KAT5/ATG13/GTF2B/MAPK8/PSMD12/PSMD2/PSMD1/GNAQ/PSMD6/AKT2/PSMC2/PIK3CB/VDAC3/MAPK9/PSMD3/PIK3R4/PSMD13/PSMA3/TBP/TBPL1/AKT1/PSMD14/PSMD8/PSMD11	3.28661378147465
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	28/1076	138/9376	1.76800818921394	RPS6/CALM1/MKNK2/PRKACB/SHC1/MAPK8/MKNK1/EIF4EBP1/FLOT2/AKT2/GSK3B/PIK3CB/RPS6KB2/FOXO1/MAPK9/HK1/CRK/RPS6KB1/MAP2K2/BAD/PYGB/PRKACA/PRKAB2/EIF4E/MAPK3/CBL/PCK2/AKT1	3.27242078786078
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	38/1076	205/9376	1.61523256868256	HLA-G/CCNE1/ATP6V0D1/SNW1/HDAC1/SKP2/PRKACB/CDK1/CDC20/GTF2B/YWHAQ/USP7/CASP3/RANBP1/GTF2H3/SND1/POLB/DDX3X/DNAJA3/GTF2A2/PIK3CB/VDAC3/PKM/IRF3/DDB1/CCNA2/BAD/PRKACA/MDM2/CDC42/MAPK3/ATF4/TBP/TRAF3/TBPL1/BAX/CDK4/HDAC3	3.20671696352274
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	19/1076	83/9376	1.99471491915618	GSDMD/POLR2E/POLR3D/POLR2K/POLR3K/CASP3/CHUK/POLR3GL/TREX1/TBK1/IRF3/G3BP1/POLR3C/POLR1C/DDX41/NFKBIB/PYCARD/PCBP1/POLR3H	3.27727161885877
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	32/1076	170/9376	1.64023616881697	IGF2/MGST3/ACTB/GSTP1/SMARCE1/SHC1/GSTA4/SMARCB1/AKT2/ARID1A/TXNRD1/GSK3B/PIK3CB/GSTO1/ACTG1/RPS6KB2/GAB1/ACTL6A/NQO1/RPS6KB1/MAP2K2/SMARCA2/BAD/DVL3/SMARCD2/PTEN/FRAT2/MAPK3/TXNRD2/AKT1/BAX/CDK4	3.03306633121355
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	19/1076	86/9376	1.92513184058096	PTK2/SHC1/MAPK8/EIF4EBP1/PAK1/AKT2/GSK3B/PIK3CB/RPS6KB2/MAPK9/CRK/GAB1/RPS6KB1/MAP2K2/BAD/MAPK3/CBL/AKT1/MAP2K7	3.10311395783121
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	24/1076	122/9376	1.71418124200134	LEP/RAB8A/EEF2/PPP2R2A/CAB39/PPP2R1A/PPP2R5E/EIF4EBP1/AKT2/ELAVL1/STRADB/PIK3CB/RPS6KB2/FOXO1/PFKL/CCNA2/RPS6KB1/PPP2R5C/PRKAB2/AKT1S1/STK11/PPP2R3B/PCK2/AKT1	2.85875103386592
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/1076	149/9376	1.63748409470822	NDUFV3/GNB2/GNB5/NDUFA9/NDUFB5/PRKACB/MAPK13/NDUFS8/NDUFS5/NDUFS3/GNB1/NDUFS2/MAPK8/NDUFA8/NDUFB9/NDUFA10/GNAQ/NDUFB2/MAPK9/GNAI3/NDUFS7/PRKACA/NDUFB6/NDUFA13/NDUFB1/MAPK3/NDUFA4/MT-ND4	2.8241317616007
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1076	31/9376	2.5297997361794	GRHPR/DLD/HYI/CS/ACO1/MDH1/GCSH/PCCB/AMT	3.07169791852503
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/1076	137/9376	1.65370526144412	TUBA1B/TUBA1C/ACTB/EIF2S1/CAPN1/BIRC5/AIFM1/MAPK8/CASP3/CHUK/ENDOG/AKT2/DFFA/TUBA4A/PIK3CB/ACTG1/MAPK9/MAP2K2/HTRA2/BAD/LMNA/MAPK3/ATF4/AKT1/BAX/LMNB1	2.7751247337417
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/1076	85/9376	1.84526568991909	AK3/RRM2/TYMS/HPRT1/NT5C3B/PNP/ITPA/UPP1/NTPCR/TK1/NUDT16/AK2/NME4/AK1/ASMTL/UCK1/GMPS/IMPDH1	2.81853999244852
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/1076	67/9376	1.95084059257615	GAPDH/TPI1/ALDOA/DLD/PGM1/PDHB/PGM2/PDHA1/AKR1A1/BPGM/PKM/PFKL/HK1/ENO1/PCK2	2.81220080293532
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	20/1076	99/9376	1.76035447410912	GNAS/PTK2/PRKACB/MAPK13/SHC1/MMP2/MAPK8/AKT2/PIK3CB/RPS6KB2/MAPK9/RPS6KB1/MAP2K2/BAD/PRKACA/MDM2/MAPK3/AKT1/BAX/CDK4	2.73831025248501
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/1076	32/9376	2.45074349442379	ATG3/ATG13/ATG4B/ATG12/ATG4A/ATG10/MLST8/ATG4C/PIK3R4	2.95972890368095
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/1076	33/9376	2.37647854004731	DLD/PDHB/PDHA1/IDH3B/CS/ACO1/GPT2/IDH1/BCKDHB	2.8519109987987
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/1076	205/9376	1.4877142079971	HLA-G/CCNE1/PSMC6/SNW1/HDAC1/SKP2/MAPK13/IRAK1/MAPK8/USP7/CASP3/PSMD12/CHUK/PSMD2/PSMD1/PSMD6/AKT2/PSMC2/TBK1/PIK3CB/MAPK9/IRF3/CCNA2/PSMD3/MDM2/NFKBIB/PSMD13/TRAF3/AKT1/BAX/CDK4/MAP2K7/PSMD14/PSMD8/PSMD11	2.54206539729254
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1076	63/9376	1.93638992152003	POLR2C/MNAT1/POLR2M/POLR2E/RAD23A/POLR2K/GTF2H3/CUL4B/POLD2/DDB1/RAD23B/RPA3/CUL4A/POLR2D	2.6849421427167
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	23/1076	122/9376	1.64275702358462	ACTB/HDAC1/DIO2/PRKACB/MED16/MED4/MED30/AKT2/NCOA2/GSK3B/ATP1B3/PIK3CB/ACTG1/FOXO1/PFKL/MAP2K2/BAD/PRKACA/MDM2/MED13L/MAPK3/AKT1/HDAC3	2.57285153632425
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/1076	110/9376	1.66353497803312	GAPDH/RPS6/ALDOA/MKNK2/PDHB/PDHA1/MKNK1/EIF4EBP1/AKT2/ARNT/PIK3CB/RPS6KB2/PFKL/VHL/HK1/RPS6KB1/MAP2K2/EIF4E/MAPK3/ENO1/AKT1	2.52038417336975
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/1076	77/9376	1.81065031622652	HDAC1/SHC1/CHUK/AKT2/PIK3CB/BCR/CRK/MAP2K2/BAD/CTBP1/MDM2/MAPK3/CBL/AKT1/BAX/CDK4	2.57165984027014
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	25/1076	138/9376	1.57857874036959	CALM1/CCNE1/CCNB1/CDC26/ANAPC13/PRKACB/CDK1/MAPK13/PTTG1/ANAPC11/CDC20/CDC23/CCNB2/ANAPC16/ANAPC5/YWHAQ/PPP2R1A/PPP2R5E/ANAPC15/CUL1/PPP2R5C/PRKACA/MAPK3/ANAPC10/PPP3R1	2.4652772248921
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1076	98/9376	1.68940141112207	ARPC5L/CFL1/CFL2/PAK1/AKT2/PIK3CB/RPS6KB2/CRK/ARPC5/RPS6KB1/PIP5K1C/WASF2/DOCK1/CDC42/ARPC1A/ARPC2/MAPK3/ARPC3/AKT1	2.47007846551465
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/1076	47/9376	2.03938938543067	GRHPR/DLD/PDHB/ACYP2/PDHA1/GLO1/LDHD/AKR1A1/PKM/MDH1/PCK2	2.57194920663616
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1076	19/9376	2.75171199373899	DLD/PDHB/PDHA1/GCSH/AMT/BCKDHB	2.75184467497539
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/1076	120/9376	1.59752168525403	CALM1/ARHGDIA/RPS6KA5/MAPK13/SHC1/IRAK1/MAPK8/AKT2/GSK3B/PIK3CB/MAPK9/CRK/GAB1/MAP2K2/BAD/NFKBIB/CDC42/MAPK3/ATF4/AKT1/BAX/MAP2K7	2.37183978199107
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	16/1076	80/9376	1.74275092936803	RPS6/SHC1/EIF4EBP1/AKT2/GSK3B/PIK3CB/RPS6KB2/GAB1/RPS6KB1/MAP2K2/BAD/EIF4E/PTEN/MAPK3/AKT1/BAX	2.40210986911292
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/1076	87/9376	1.70268768961244	RALA/RALB/BIRC5/MAPK8/CASP3/AKT2/GSK3B/PIK3CB/RPS6KB2/MAPK9/RPS6KB1/MLH1/MAP2K2/BAD/MAPK3/AKT1/BAX	2.37077433849666
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	22/1076	122/9376	1.5713328051679	BCL10/MAPK13/PPP2R2A/MAPK8/PPP2R1A/PPP2R5E/CHUK/PAK1/AKT2/GSK3B/PIK3CB/MAPK9/PPP2R5C/MAP2K2/NFKBIB/CDC42/PPP2R3B/MAPK3/AKT1/CDK4/PPP3R1/MAP2K7	2.28695203878258
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/1076	37/9376	2.11956194112328	NANS/PGM1/GMPPA/GNPNAT1/PGM2/MPI/PMM1/HK1/NAGK	2.45669662079662
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1076	75/9376	1.74275092936803	MGST3/GSTP1/BIRC5/TOP2A/GSTA4/CASP3/AKT2/PIK3CB/GSTO1/MLH1/BAD/MDM2/MAPK3/AKT1/BAX	2.32520763899746
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1076	75/9376	1.74275092936803	CCNE1/CCNB1/RRM2/CDK1/EI24/CCNB2/CASP3/SHISA5/SIAH1/MDM2/TP53I3/ZMAT3/PTEN/BAX/CDK4	2.32520763899746
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/1076	82/9376	1.70024480913954	MGST3/GSTP1/RRM2/UGT2B7/HPRT1/TPMT/ITPA/GSTA4/UPP1/TK1/NME4/GSTO1/UCK1/UMPS/GMPS/IMPDH1	2.29302198099789
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/1076	174/9376	1.45229244114002	HSP90AA1/UBXN6/EIF2S1/CAPN1/NSFL1C/BAG1/UBE2J1/UBE2J2/RAD23A/MAPK8/SEC13/UBQLN2/VCP/UBE2D4/CUL1/MAPK9/EDEM1/DNAJA2/PREB/RAD23B/HSP90AB1/UBXN1/HSPBP1/PLAA/SEC24A/NGLY1/ATF4/BAX/MAP2K7	2.16823108831868
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/1076	44/9376	1.98039878337276	GNAS/DYNLL1/ARHGDIA/PRKACB/DYNC1LI2/DCTN2/NSF/STX4/PRKACA/DCTN5	2.3468993490181
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1076	38/9376	2.06378399530425	PGM1/GMPPA/GNPDA1/GNPNAT1/PGM2/MPI/PMM1/HK1/NAGK	2.36576195406326
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	17/1076	90/9376	1.64593143329203	PRKACB/ATG13/EIF4EBP1/AKT2/PIK3CB/RPS6KB2/FOXO1/RPS6KB1/EHMT1/PRKACA/PRKAB2/AKT1S1/STK11/EIF4E/ATF4/AKT1/BAX	2.21689978916752
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	14/1076	70/9376	1.74275092936803	PRCC/PAK1/AKT2/ARNT/PIK3CB/VHL/CRK/GAB1/MAP2K2/BAD/CDC42/TFE3/MAPK3/AKT1	2.24576044095539
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	15/1076	77/9376	1.69748467146237	RALA/RALB/MAPK8/CHUK/AKT2/PIK3CB/RPS6KB2/MAPK9/RPS6KB1/BAD/CDC42/MAPK3/AKT1/BAX/CDK4	2.21265974107455
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	23/1076	133/9376	1.50688990133326	CCNB1/SKP2/MAPK13/ATG12/CCNB2/MAPK8/USP7/CHUK/AKT2/PIK3CB/SETD7/FOXO1/MAPK9/MAP2K2/MDM2/PRKAB2/STK11/PTEN/MAPK3/HOMER1/PCK2/AKT1/BNIP3	2.11975520623481
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	23/1076	133/9376	1.50688990133326	CALM1/GNAS/GNB2/GNB5/PRKACB/MAPK13/KIF5B/GSK3A/GNB1/PPP2R2A/MAPK8/PPP2R1A/PPP2R5E/GNAQ/AKT2/GSK3B/MAPK9/GNAI3/PPP2R5C/PRKACA/PPP2R3B/ATF4/AKT1	2.11975520623481
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1076	71/9376	1.71820514163045	ATP6V0D1/ATP6V1E1/MAPK13/ATP6V1A/MAPK8/CASP3/CHUK/PAK1/MAPK9/CSK/JAM3/ATP6V1B1/CDC42/F11R	2.18711804216042
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/1076	71/9376	1.71820514163045	PDHB/PDHA1/AKT2/PIK3CB/PKM/PFKL/HK1/MAP2K2/SIRT6/IDH1/PTEN/G6PD/MAPK3/AKT1	2.18711804216042
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/1076	33/9376	2.11242536893095	VAMP3/STX8/BET1L/STX4/USE1/BNIP1/SNAP29/YKT6	2.30482208962576
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	28/1076	170/9376	1.43520664771485	TUBA1B/TUBA1C/MYL6/ACTB/RAB8A/PRKACB/MYH9/PPP2R2A/MAPK8/RAB13/ARPC5L/PPP2R1A/HSPA4/TUBA4A/ACTG1/MAPK9/ARPC5/JAM3/PRKACA/PRKAB2/STK11/CDC42/F11R/ARPC1A/ARPC2/ARPC3/CDK4/MAP2K7	2.06175579355872
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	32/1076	200/9376	1.39420074349442	GAPDH/RPS3/TUBA1B/TUBA1C/TUBB/ACTB/MAPK13/IRAK1/MYH9/MAPK8/GNA13/CASP3/ARPC5L/CHUK/PAK1/CASP4/TUBA4A/ACTG1/MAPK9/ARPC5/TUBB6/WASF2/NFKBIB/CDC42/ARPC1A/PYCARD/SEC24A/ARPC2/MAPK3/ARPC3/BAIAP2L1/BAX	2.02888981557522
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/1076	142/9376	1.47274726425467	CALM1/MGST3/HSP90AA1/ACTB/GSTP1/PTK2/MAPK13/MMP2/SUMO1/MAPK8/GSTA4/CHUK/AKT2/PIK3CB/GSTO1/ACTG1/MAPK9/NQO1/HSP90AB1/SUMO3/PIAS4/TXN/AKT1/MAP2K7	2.04376514864974
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	10/1076	46/9376	1.89429448844351	UGT2B7/HMOX2/MMAB/ALAS2/HCCS/COX10/PPOX/ALAD/BLVRB/UROD	2.18912910892167
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1076	59/9376	1.77228908071325	MGST3/GSTP1/RRM2/PRDX6/GSTA4/GSS/GSTO1/PGD/IDH1/G6PD/GGCT/SMS	2.14249876476187
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	26/1076	157/9376	1.44304217081429	CALM1/HLA-G/CCNE1/SLC25A5/CCNB1/CAPN1/CDK1/MAPK13/PPID/ZFP36L2/CCNB2/EIF4EBP1/AKT2/PIK3CB/VDAC3/FOXO1/CCNA2/MAP2K2/HUS1/MDM2/PTEN/RAD1/MAPK3/AKT1/CDK4/PPP3R1	2.01560632613674
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	22/1076	130/9376	1.47463540177295	GNAS/COL3A1/COL1A2/COL1A1/GNB2/GNB5/PRKACB/MAPK13/SHC1/MMP2/GNB1/MAPK8/AKT2/PIK3CB/MAPK9/GNAI3/MAP2K2/PRKACA/MAPK3/ATF4/AKT1/MAP2K7	1.96203878088156
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/1076	54/9376	1.7750240947267	TST/AHCYL1/MAT2A/SDSL/APIP/GSS/ENOPH1/MDH1/CDO1/DNMT3A/SMS	2.05641263119256
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1076	35/9376	1.99171534784918	TPI1/ALDOA/GMPPA/AKR1B1/MPI/PFKL/PMM1/HK1	2.11629934861251
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/1076	68/9376	1.66586485895473	DUSP6/CHUK/EIF4EBP1/AKT2/PIK3CB/RPS6KB2/CCNA2/RPS6KB1/MAP2K2/BAD/MAPK3/PIM1/AKT1	1.98410701367186
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	12/1076	62/9376	1.68653315745293	HDAC1/PRKACB/FOXA2/AKT2/PIK3CB/RPS6KB2/FOXO1/RPS6KB1/PRKACA/PRKAB2/AKT1S1/AKT1	1.95272898552833
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/1076	90/9376	1.54911193721603	MAPK13/EML4/CHUK/AKT2/CSNK2B/PIK3CB/RPS6KB2/RPS6KB1/MAP2K2/TICAM1/NFKBIB/CSNK2A2/PTEN/MAPK3/AKT1/PPP3R1	1.88460581897896
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	15/1076	83/9376	1.57477493617593	HDAC1/YY1/PCGF5/USP7/CBX4/CSNK2B/UBE2D4/FBRS/YAF2/BMI1/SUZ12/HCFC1/PHC1/AURKB/USP45	1.89370195347898
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/1076	163/9376	1.3899240540972	CCNE1/BIRC5/MAPK13/IRAK1/MAPK8/YWHAQ/CASP3/CHUK/AKT2/DDX3X/TBK1/PIK3CB/VDAC3/MAPK9/IRF3/DDB1/CCNA2/MAP2K2/BAD/TICAM1/MAPK3/ATF4/TRAF3/AKT1/BAX/MAP2K7	1.80811488552709
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	48/1076	333/9376	1.25603670585083	HLA-G/CCNE1/GNAS/COL1A2/ATP6V0D1/COL1A1/HDAC1/PTK2/ATP6V1E1/PRKACB/ATP6V1A/PPP2R2A/CASP3/PPP2R1A/PPP2R5E/CHUK/EIF4EBP1/AKT2/COL6A2/GSK3B/TBK1/PIK3CB/RPS6KB2/PKM/FOXO1/IRF3/CCNA2/RPS6KB1/PPP2R5C/MAP2K2/BAD/PRKACA/MDM2/DVL3/TICAM1/ATP6V1B1/CDC42/HEY2/MAML3/PTEN/PPP2R3B/MAPK3/TBP/TRAF3/TBPL1/AKT1/BAX/CDK4	1.71285582904944
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	18/1076	107/9376	1.46586526769274	CALM1/GNAS/PRKACB/PDHB/PDHA1/PPP4C/GNAQ/AKT2/PKM/FOXO1/PFKL/PYGB/PRKACA/PRKAB2/ATF4/PCK2/AKT1/PPP3R1	1.74497218447213
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	37/1076	250/9376	1.28963568773234	HLA-G/RAB4A/RAB8A/STAM/RAB7A/SNX2/EPS15/EPN1/CHMP4A/VPS26A/KIF5B/SNF8/CHMP6/ARPC5L/SH3GLB2/SNX6/VPS28/CAPZB/MVB12A/ARPC5/PIP5K1C/VPS37D/CLTA/VTA1/MDM2/CHMP7/CAPZA1/CDC42/VPS37C/ARPC1A/AP2M1/ARPC2/ZFYVE9/ARPC3/CBL/DAB2/CHMP2A	1.67122364910481
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/1076	93/9376	1.49914058440261	CCNE1/SKP2/PTK2/TRAF4/CASP3/CHUK/AKT2/PIK3CB/CKS2/CKS1B/PTEN/TRAF3/AKT1/BAX/CDK4/ZBTB17	1.74169822759288
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	13/1076	72/9376	1.57331681123503	PIN1/MAPK13/ATG12/OTUD5/MAPK8/CHUK/SIKE1/DDX3X/TBK1/MAPK9/IRF3/NFKBIB/TRAF3	1.75824261399286
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/1076	101/9376	1.46667157422062	COL3A1/COL1A2/COL1A1/MAPK13/MMP2/MAPK8/CASP3/AKT2/PIK3CB/FOXO1/MAPK9/CDC42/MAPK3/PIM1/AKT1/BAX/CDK4	1.69772679640445
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/1076	87/9376	1.50237149083451	UQCRH/TPM1/COX4I1/UQCRC2/UQCR10/CYC1/COX5B/COX5A/COX6C/MYL4/COX7C/ATP1B3/UQCRB/UQCRC1/COX7A2L	1.69493425951385
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/1076	59/9376	1.62459832398715	ILK/AKT2/GSK3B/PIK3CB/MLH1/MAP2K2/BAD/PTEN/MAPK3/AKT1/BAX	1.7327723141947
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1076	39/9376	1.78743685063388	TYMS/AHCYL1/DLD/MAT2A/MTHFS/GCSH/GART/AMT	1.77417758035221
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	20/1076	125/9376	1.39420074349442	MAPK13/PPP2R2A/MAPK8/GNA13/PPP2R1A/PPP2R5E/GNAQ/AKT2/PIK3CB/MAPK9/GNAI3/PPP2R5C/MAP2K2/CERS5/PTEN/PPP2R3B/MAPK3/AKT1/BAX/SPTSSA	1.59746309131152
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/1076	75/9376	1.51038413878563	GAPDH/TPI1/ALDOA/MAT2A/SDSL/IDH3B/CS/ACO1/GPT2/PKM/PFKL/IDH1/ENO1	1.59777531256302
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1076	15/9376	2.32366790582404	NTPCR/AK2/AK1/NFS1	1.84721001061467
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1076	41/9376	1.70024480913954	GRHPR/DLD/SDSL/ALAS2/BPGM/GCSH/GCAT/AMT	1.61784679540179
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1076	41/9376	1.70024480913954	RPS6KA5/MMP2/DAPK3/RASSF1/MAP2K2/MDM2/MAPK3/CDK4	1.61784679540179
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/1076	78/9376	1.45229244114002	CALM1/MAPK13/IRAK1/MAPK8/CASP3/CFL1/CFL2/MAPK9/IRF3/GNAI3/TICAM1/PYCARD/MAPK3	1.44419084580116
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1076	93/9376	1.40544429787744	CGA/CALM1/GNAS/PRKACB/MAPK13/MMP2/MAPK8/GNAQ/MAPK9/MAP2K2/PRKACA/CDC42/MAPK3/ATF4/MAP2K7	1.41475495495111
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1076	71/9376	1.47274726425467	CGA/MAPK13/SHC1/MAPK8/AKT2/SOCS6/GSK3B/PIK3CB/MAPK9/MAP2K2/MAPK3/AKT1	1.43963613054359
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/1076	139/9376	1.31646652937873	KRT18/CALM1/KRT19/GNAS/HSP90AA1/PRKACB/KRT23/SHC1/MMP2/GNAQ/AKT2/NCOA2/PIK3CB/FKBP4/GNAI3/HSP90AB1/MAP2K2/PRKACA/MAPK3/ATF4/AKT1	1.35338837027417
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	15/1076	94/9376	1.39049276279364	HSP90AA1/MAPK13/TRAF4/ANAPC5/MAPK8/CASP3/CHUK/ELAVL1/MAPK6/GSK3B/TBK1/MAPK9/HSP90AB1/MAPK3/TRAF3	1.36996307520162
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1076	17/9376	2.05029521102121	SEPHS2/TXNRD1/TXNRD2/SCLY	1.56053620888163
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1076	187/9376	1.25813569767211	HSP90AA1/GSDMD/SHARPIN/BRCC3/MAPK13/PKN1/SUGT1/ATG12/MAPK8/CHUK/DNM1L/RNASEL/CASP4/TBK1/RBCK1/VDAC3/MAPK9/IRF3/HSP90AB1/TICAM1/NFKBIB/TXN/CARD8/PYCARD/TRIP6/MAPK3/TRAF3	1.28377073907748
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1076	51/9376	1.53772140826591	GNAS/ACTB/ATP6V0D1/ATP6V1E1/PRKACB/ATP6V1A/ACTG1/PRKACA/ATP6V1B1	1.38634309240497
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/1076	44/9376	1.58431902669821	HMGB1/APTX/POLB/POLD2/TDG/SMUG1/UNG/NTHL1	1.39875524800148
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	32/1076	227/9376	1.22837069911403	CALM1/HLA-G/GNAS/GNB2/GNB5/PTK2/PRKACB/MAPK13/GNB1/GNA13/CASP3/CHUK/EIF4EBP1/GNAQ/AKT2/GSK3B/TBK1/PIK3CB/RPS6KB2/IRF3/CRK/GNAI3/RPS6KB1/MAP2K2/PRKACA/MDM2/MAPK3/ATF4/AKT1/BAX/CDK4/PPP3R1	1.25406262263228
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1076	73/9376	1.43239802413811	PPIA/RAN/PIN1/CHMP4A/NELFE/CPSF6/CHMP6/SMARCB1/SUPT4H1/PSIP1/APOBEC3C/NELFCD	1.33532305698319
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	26/1076	180/9376	1.25865344898802	HLA-G/EIF2S1/IRAK1/EIF2B2/CASP3/CHUK/EIF4EBP1/SRPK1/ZC3HAV1/RNASEL/AKT2/EIF2B1/SRSF2/TBK1/PIK3CB/IRF3/SRSF7/EIF2B5/BAD/SRSF6/TICAM1/HCFC1/TRAF3/AKT1/BAX/EIF2B3	1.26155960002504
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/1076	196/9376	1.24482209240574	RPS27A/UBA52/CALM1/HLA-G/GNB2/GNB5/UBB/ATG3/MAPK13/GNB1/MAPK8/CASP3/CHUK/AKT2/GSK3B/TBK1/PIK3CB/MAPK9/IRF3/MAP2K2/TICAM1/MAPK3/TRAF3/AKT1/BAX/CDK4/PPP3R1/MAP2K7	1.24712512319573
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1076	52/9376	1.50814984272233	CGA/GNAS/PRKACB/ACOT4/CYP11A1/CYP19A1/HSD17B1/PRKACA/HSD3B1	1.32295497121659
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/1076	31/9376	1.68653315745293	ALDOA/PGM1/PGM2/PFKL/PGD/G6PD	1.37849577357967
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1076	31/9376	1.68653315745293	SRP72/SRP19/BAG6/SRP14/IMMP1L/UBL4A	1.37849577357967
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1076	18/9376	1.93638992152003	PRDX1/MMAB/ZNF143/HCFC1	1.43170713891518
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1076	60/9376	1.45229244114002	PTK2/MAPK13/AKT2/PIK3CB/MAP2K2/BAD/CDC42/MAPK3/AKT1/PPP3R1	1.26541489647601
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1076	136/9376	1.28143450688826	CCNE1/EIF2S1/IRAK1/MAPK8/CASP3/CHUK/AKT2/CSNK2B/GSK3B/TBK1/PIK3CB/MAPK9/IRF3/BAD/NFKBIB/CSNK2A2/TRAF3/AKT1/BAX/CDK4	1.19031948201898
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	26/1076	183/9376	1.23801978588986	RAN/POP5/IMP3/POP4/EMG1/EIF6/UTP6/CSNK2B/RBM28/WDR43/GTPBP4/GNL3/NXT1/RRP7A/WDR36/IMP4/TCOF1/RPP30/TBL3/GNL2/RIOK1/RPP25L/UTP14A/CSNK2A2/WDR3/NOB1	1.17074605401724
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1076	12/9376	2.17843866171004	NQO1/GGCX/COQ6	1.47068488985247
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/1076	106/9376	1.31528372027776	CCNE1/HSP90AA1/GSTP1/CHUK/AKT2/GSK3B/PIK3CB/FOXO1/HSP90AB1/MAP2K2/BAD/MDM2/PTEN/MAPK3/ATF4/AKT1	1.17535034653352
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1076	32/9376	1.63382899628253	PGM1/PGM2/AKR1B1/GLA/PFKL/HK1	1.29310385157617
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1076	32/9376	1.63382899628253	HIBCH/DLD/SUCLG2/SUCLG1/PCCB/BCKDHB	1.29310385157617
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1076	32/9376	1.63382899628253	BIRC5/MAPK8/CASP3/MAPK9/HTRA2/BAX	1.29310385157617
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/1076	122/9376	1.28563593150101	GNAS/PTK2/PRKACB/MAPK13/SHC1/MAPK8/GNAQ/AKT2/GSK3B/PIK3CB/MAPK9/CRK/GNAI3/MAP2K2/PRKACA/MAPK3/ATF4/AKT1	1.14335404861589
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	15/1076	99/9376	1.32026585558184	MAPK8/EIF4EBP1/AKT2/PCYT1A/PIK3CB/RPS6KB2/MAPK9/RPS6KB1/PIP5K1C/MAP2K2/WASF2/SLC44A2/LYPLA1/MAPK3/AKT1	1.15339266845003
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1076	70/9376	1.36930430164631	LEP/MAPK8/CHUK/AKT2/MAPK9/TNFRSF1B/PRKAB2/STK11/NFKBIB/PCK2/AKT1	1.11661791122578
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1076	140/9376	1.24482209240574	RPS6/CALM1/GNB2/GNB5/PRKACB/GNB1/GNA13/GNAQ/MYL4/AKT2/RPS6KB2/GNAI3/RPS6KB1/MAP2K2/PRKACA/PRKAB2/PIK3R4/TFAM/MAPK3/AKT1	1.05081288337616
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	22/1076	156/9376	1.22886283481079	EIF2S1/PPP2R2A/YWHAQ/CASP3/PPP2R1A/CHUK/RNASEL/AKT2/GSK3B/PSME3/TBK1/PIK3CB/IRF3/MAP2K2/EIF3E/BAD/TICAM1/MAPK3/TRAF3/AKT1/BAX/CDK4	1.0378266995911
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	24/1076	173/9376	1.20884457528418	SLC25A5/ACTB/EIF2S1/PABPN1/RAE1/CASP3/CHUK/RNASEL/AKT2/FDPS/TBK1/PIK3CB/ACTG1/NXT1/IRF3/MAP2K2/TICAM1/NFKBIB/PYCARD/MAPK3/TRAF3/AKT1/BAX/CDK4	0.998238388583198
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	15/1076	103/9376	1.2689933951709	GNAS/MAPK13/IRAK1/PPP2R2A/MAPK8/PPP2R1A/CHUK/GNAQ/AKT2/PIK3CB/MAPK9/GNAI3/TICAM1/MAPK3/AKT1	0.988331930762003
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1076	42/9376	1.45229244114002	SAT2/SLC3A2/NCOA4/GSS/VDAC3/PCBP2/PCBP1	1.05770073059098
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	29/1076	216/9376	1.16990224425169	CALM1/HSP90AA1/EIF2S1/PTK2/MAPK13/IRAK1/MAPK8/CASP3/CHUK/HSPA4/HSPA2/AKT2/GSK3B/TBK1/PIK3CB/MAPK9/IRF3/HSP90AB1/BAD/TICAM1/CDC42/PYCARD/MAPK3/ATF4/TRAF3/AKT1/BAX/PPP3R1/MAP2K7	0.909559222910044
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/1076	73/9376	1.3130315221266	KIF5B/EML4/AKT2/RASSF1/PIK3CB/MAP2K2/BAD/MAPK3/AKT1/BAX/CDK4	0.966697777797158
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1076	28/9376	1.55602761550717	MOCS2/CBR1/SPR/AKR1B1/GGH	1.06088608519567
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1076	89/9376	1.27279562257216	TUBA1B/TUBA1C/TUBB/GNAS/PRKACB/CDK1/GNAQ/TUBA4A/GNAI3/TUBB6/MAP2K2/PRKACA/MAPK3	0.930995121702786
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/1076	105/9376	1.24482209240574	CALM1/BCL10/MAPK13/MAPK8/CHUK/PAK1/AKT2/PIK3CB/MAPK9/MDM2/PYCARD/MAPK3/AKT1/CLEC4E/PPP3R1	0.90831124752725
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	21/1076	154/9376	1.18823927002366	CALM1/TPM1/GNAS/PRKACB/RPS6KA5/MAPK13/PPP2R2A/PPP2R1A/PPP2R5E/GNAQ/MYL4/AKT2/CREM/ATP1B3/GNAI3/PPP2R5C/PRKACA/PPP2R3B/MAPK3/ATF4/AKT1	0.848029107615022
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/1076	59/9376	1.32921681053494	RRM2/TYMS/NT5C3B/UPP1/TK1/NME4/ASMTL/UCK1/UMPS	0.913319413060354
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	12/1076	83/9376	1.25981994894074	PRDX1/GNPAT/FAR1/PMVK/ECI2/NUDT12/MPV17/CROT/PXMP2/IDH1/SLC27A2/NUDT7	0.856024704444131
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/1076	76/9376	1.26120133046371	CALM1/SHC1/AKT2/PIK3CB/MAP2K2/MDM2/PTEN/MAPK3/AKT1/BAX/CDK4	0.823177391936341
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/1076	30/9376	1.45229244114002	TYMS/CHUK/GGH/GART/ABCG2	0.893346204167686
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/1076	109/9376	1.1991405477303	MAPK13/IRAK1/MAPK8/CHUK/AKT2/TBK1/PIK3CB/MAPK9/IRF3/MAP2K2/TICAM1/MAPK3/TRAF3/AKT1/MAP2K7	0.752932584551423
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1076	23/9376	1.51543559075481	FNTA/IDI1/PMVK/FDPS	0.891077713402241
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1076	126/9376	1.17566530949431	GNAS/COL3A1/ACTB/COL1A2/COL1A1/PRKACB/MAPK13/GNA13/GNAQ/AKT2/TLN2/PIK3CB/ACTG1/GNAI3/PRKACA/MAPK3/AKT1	0.714748313129414
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	22/1076	168/9376	1.14108691803859	HMGB1/SLC25A5/PPIA/HSP90AA1/SHARPIN/CAPN1/AIFM1/CHMP4A/PPID/CHMP6/MAPK8/DNM1L/RBCK1/VDAC3/MAPK9/HSP90AB1/PYGB/TICAM1/CHMP7/PYCARD/BAX/CHMP2A	0.664372212779634
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/1076	103/9376	1.18439383549284	PRDX1/GNAS/COL3A1/COL1A2/COL1A1/RAB7A/PTK2/PRKACB/SERPINB6/CASP3/GNAQ/PIK3CB/SERPINB9/PRKACA	0.677497361366305
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/1076	128/9376	1.15729553903346	AK3/RRM2/HPRT1/PGM1/PNP/ITPA/PGM2/NTPCR/NUDT16/HDDC3/AK2/NME4/AK1/GMPS/GART/ADPRM/IMPDH1	0.645134411781445
Cellular Processes	Cell motility	hsa04814	Motor proteins	25/1076	194/9376	1.12290652665466	TUBA1B/TPM1/TUBA1C/TUBB/MYL6/ACTB/DYNLL1/ACTR10/KIF22/DYNC1LI2/KIF5B/DCTN2/MYH9/KIF2A/MYL4/CAPZB/TUBA4A/ACTG1/TUBB6/DCTN5/CAPZA1/KLC2/TNNI2/KIF2C/KIF21A	0.622816190908586
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1076	48/9376	1.27075588599752	HIBCH/ACADM/DLD/ACAD8/PCCB/HADH/BCKDHB	0.677106502089041
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1076	10/9376	1.74275092936803	TST/ETHE1	0.846094466674193
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1076	73/9376	1.19366502011509	AKT2/PIK3CB/MAP2K2/BAD/MDM2/PTEN/MAPK3/AKT1/BAX/CDK4	0.598072498611126
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1076	59/9376	1.18152605380883	CGA/GNAS/PRKACB/AKT2/PIK3CB/GNAI3/PRKACA/AKT1	0.503592962493183
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/1076	109/9376	1.11919784454828	MAPK8/AKT2/GSK3B/PIK3CB/RPS6KB2/FOXO1/MAPK9/RPS6KB1/PYGB/PRKAB2/SLC27A2/PTEN/PCK2/AKT1	0.450676380032065
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1076	76/9376	1.14654666405791	CALM1/GAST/GNAS/ACTB/PRKACB/GNAQ/ATP1B3/ACTG1/GNAI3/PRKACA	0.461842596674397
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	25/1076	203/9376	1.07312249345322	PGF/ACTB/COL1A2/COL1A1/PTK2/SHC1/PARVA/ILK/MAPK8/PAK1/AKT2/COL6A2/TLN2/GSK3B/PIK3CB/ACTG1/MAPK9/CRK/PIP5K1C/BAD/DOCK1/CDC42/PTEN/MAPK3/AKT1	0.379224198538347
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	22/1076	178/9376	1.07698091140721	CBY1/CTNNBIP1/PRKACB/SERPINF1/MAPK8/CSNK2B/GSK3B/CUL1/MAPK9/SIAH1/SENP2/CTBP1/PRKACA/CCAR2/DVL3/NOTUM/CACYBP/CSNK2A2/TLE1/FRAT2/DAAM1/PPP3R1	0.37333531636613
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	15/1076	119/9376	1.09837243447565	RPS6KA5/MAPK13/MAPK8/CASP3/CHUK/DNM1L/AKT2/PIK3CB/MAPK9/TNFRSF1B/MAPK3/ATF4/TRAF3/AKT1/MAP2K7	0.388834235228009
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	29/1076	238/9376	1.06176001999313	CALM1/PGF/IGF2/RALA/PLA2G2A/RALB/GNB2/GNB5/ETS2/PRKACB/SHC1/GNB1/MAPK8/RGL2/CHUK/PAK1/AKT2/RASSF1/TBK1/PIK3CB/MAPK9/EFNA4/GAB1/MAP2K2/BAD/PRKACA/CDC42/MAPK3/AKT1	0.347474594889738
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/1076	69/9376	1.13657669306611	MAPK13/MAPK8/AKT2/PIK3CB/MAPK9/MAP2K2/MAPK3/AKT1/MAP2K7	0.409967103003305
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1076	36/9376	1.21024370095002	PGM1/PGM2/HK1/GBE1/PYGB	0.455044147218974
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1076	28/9376	1.24482209240574	ATP6V0D1/ATP6V1E1/ATP6V1A/ATP6V1B1	0.467114121561801
NA	NA	hsa04517	IgSF CAM signaling	36/1076	299/9376	1.04914771667641	TUBA1B/TUBA1C/TUBB/MYL6/ACTB/DYNLL1/PTK2/MAPK13/MYH9/MAPK8/ARPC5L/PAK1/AKT2/GSK3B/TUBA4A/PIK3CB/ACTG1/FOXO1/MAPK9/CSK/ARPC5/PTPRS/JAM3/TUBB6/MAP2K2/TRIO/PMP22/CDC42/F11R/ARPC1A/ARPC2/SPTBN1/MAPK3/ARPC3/SRGAP2/AKT1	0.310971436716526
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1076	53/9376	1.15087325524304	GNAS/PRKACB/GNAQ/ATP1B3/CLTA/PRKACA/AP2M1	0.396574770112252
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	28/1076	232/9376	1.05166004358416	PFN1/ACTB/ITGAE/PTK2/MYH9/GNA13/ARPC5L/CFL1/CFL2/PAK1/AKT2/DIAPH3/ENAH/PIK3CB/ACTG1/CRK/ARPC5/PIP5K1C/MAP2K2/WASF2/PIP4K2A/DOCK1/CDC42/ARPC1A/ARPC2/MAPK3/ARPC3/AKT1	0.286868841579725
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	30/1076	250/9376	1.04565055762082	ATP6V0D1/KXD1/RAB7A/AP1S1/ATP6V1E1/VPS26A/ATP6V1A/AP3M1/BLOC1S4/GLA/LAMTOR1/AP5M1/MLST8/SLC36A4/ROGDI/AP1M1/RRAGC/SNAP29/AP3S1/BLOC1S1/CLTA/AP5S1/AKT1S1/ATP6V1B1/AP3S2/AP1B1/AP2M1/TELO2/LAMTOR4/TFE3	0.263407773013233
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	28/1076	233/9376	1.04714648116534	TPM1/COL3A1/ACTB/COL1A2/EMD/COL1A1/PDLIM5/TMOD3/MYH9/MYL4/DAG1/COL6A2/DIAPH3/TLN2/ATP1B3/CAPZB/ACTG1/CSRP2/LMNA/SNTA1/DSC2/CAPZA1/TNNI2/CSRP1/SPTBN1/DAAM1/ENO1/LMNB1	0.262382951159359
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1076	21/9376	1.24482209240574	PPCS/PPCDC/PANK3	0.404381318999907
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1076	13/9376	1.34057763797541	PRKDC/XRCC4	0.442418237526256
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1076	47/9376	1.11239421023491	MAPK8/PIK3CB/PKM/MAPK9/HK1/MAPK3	0.278117329170534
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/1076	56/9376	1.08921933085502	HSF1/CASP3/EEF1A1/VCP/BCL2L13/PYCARD/BNIP3	0.241100297748244
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/1076	65/9376	1.07246211038033	CGA/KISS1/GNAQ/AKT2/PIK3CB/MAP2K2/MAPK3/AKT1	0.211067915416414
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	24/1076	204/9376	1.02514760551061	RPS6/IGF2/ACTB/COL1A2/COL1A1/PTK2/PRKACB/MAPK13/MMP2/CASP3/PAK1/AKT2/PIK3CB/ACTG1/RPS6KB2/GAB1/RPS6KB1/MAP2K2/PRKACA/MDM2/CDC42/MAPK3/CBL/AKT1	0.130747209113943
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1076	14/9376	1.24482209240574	B4GALT4/FUT8	0.330052504413158
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/1076	144/9376	1.02870714580752	ACADM/MAPK13/IRAK1/MAPK8/CASP3/CHUK/AKT2/GSK3B/TBK1/FOXO1/MAPK9/IRF3/PRKAB2/TICAM1/TRAF3/AKT1/MAP2K7	0.124990236833099
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	42/1076	362/9376	1.01098810819692	RPS6/CCNE1/PGF/IGF2/HSP90AA1/COL1A2/COL1A1/GNB2/GNB5/PTK2/PKN1/GNB1/PPP2R2A/YWHAQ/PPP2R1A/PPP2R5E/CHUK/EIF4EBP1/AKT2/COL6A2/MLST8/GSK3B/PIK3CB/RPS6KB2/EFNA4/THEM4/RPS6KB1/PPP2R5C/HSP90AB1/MAP2K2/BAD/MDM2/STK11/EIF4E/PTEN/PPP2R3B/MAPK3/ATF4/PCK2/AKT1/CDK4/ARTN	0.0767663979859044
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1076	49/9376	1.0669903649192	GNAS/PRKACB/CDK5/GNAI3/PRKACA/ATF4	0.169274727312013
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1076	23/9376	1.13657669306611	POLD2/MLH1/RPA3	0.236111843156129
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1076	23/9376	1.13657669306611	ATP1B3/MDH1/PCK2	0.236111843156129
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1076	67/9376	1.04044831604061	CALM1/PRKACB/GNAQ/MAP2K2/PRKACA/MAPK3/ATF4/PPP3R1	0.119629712629973
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1076	41/9376	1.06265300571221	BRCC3/BABAM1/UIMC1/POLD2/RPA3	0.144753610724153
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1076	50/9376	1.04565055762082	HBA2/HBA1/GYPB/GYPA/HBB/GYPC	0.116529561199174
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/1076	60/9376	1.01660470879802	GNAS/GNA13/PPP2R1A/GNAQ/GNAI3/MAP2K2/MAPK3	0.0464563277062428
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/1076	78/9376	1.00543322848156	TPI1/ISYNA1/IP6K2/PIK3CB/PIP5K1C/PIP4K2A/MTMR1/PTEN/PI4K2B	0.0173485517830698
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/1076	193/9376	0.993277731764162	GNB2/GNB5/PTK2/PRKACB/SHC1/GSK3A/GNB1/CCR7/CHUK/GNAQ/PAK1/AKT2/GSK3B/PIK3CB/CRK/GNAI3/BAD/PRKACA/NFKBIB/CDC42/MAPK3/AKT1	-0.0339746450369707
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/1076	97/9376	0.988157743456099	CALM1/GNAS/GNB2/GNB5/PRKACB/RPS6KA5/GNB1/GNAQ/GNAI3/PRKACA/MAPK3	-0.0422106920573301
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/1076	62/9376	0.98381100851421	SNW1/HDAC1/CTBP1/DVL3/HEY2/MAML3/TLE1	-0.0460468843749038
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1076	17/9376	1.02514760551061	MYH9/DAG1	0.0373644938624582
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1076	36/9376	0.968194960760017	C1GALT1/ST6GALNAC1/ST6GALNAC4/GALNT2	-0.0688377197168192
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1076	36/9376	0.968194960760017	RNASEH1/RNASEH2B/POLD2/RPA3	-0.0688377197168192
NA	NA	hsa04518	Integrin signaling	17/1076	154/9376	0.961907980495341	PGF/ACTB/COL1A2/COL1A1/ITGAE/PTK2/PARVA/ILK/AKT2/COL6A2/TLN2/GSK3B/PIK3CB/ACTG1/CDC42/FERMT2/AKT1	-0.171606813518402
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/1076	181/9376	0.962845817330403	CALM1/ATP6V0D1/RAB7A/HSPA9/BCL10/MAPK13/IRAK1/RFXANK/MAPK8/CASP3/AKT2/NFYB/MAPK9/CEBPG/BAD/MAPK3/AKT1/BAX/CLEC4E/PPP3R1	-0.181728842459572
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/1076	91/9376	0.95755545569672	BCL10/CHUK/AKT2/GSK3B/PIK3CB/MAP2K2/NFKBIB/MAPK3/AKT1/PPP3R1	-0.146488774246222
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/1076	82/9376	0.956387705140992	HLA-G/HSP90AA1/RFXANK/HSPA4/HSPA2/NFYB/PSME3/HSP90AB1/PSME1	-0.14281284123527
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	24/1076	217/9376	0.963733232830247	MGST3/GNAS/HSP90AA1/BIRC5/UGT2B7/PRKACB/GSTA4/KPNB1/EIF4EBP1/AIP/AKT2/ARNT/PIK3CB/GSTO1/RPS6KB2/GNAI3/RPS6KB1/HSP90AB1/MAP2K2/BAD/PRKACA/MAPK3/ATF4/AKT1	-0.194611011203619
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/1076	155/9376	0.955702122556661	TUBA1B/HLA-G/TUBA1C/TUBB/ACTB/ATP6V0D1/STX12/RAB7A/VAMP3/ATP6V1E1/DYNC1LI2/ATP6V1A/RILP/TUBA4A/ACTG1/TUBB6/ATP6V1B1	-0.200222317108778
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1076	37/9376	0.942027529388124	HBA2/HBA1/GNAQ/HBB	-0.127211159490232
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/1076	37/9376	0.942027529388124	NCOA4/MAP2K2/MAPK3/BAX	-0.127211159490232
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1076	18/9376	0.968194960760017	OXSM/CBR4	-0.0486287823980895
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/1076	65/9376	0.938404346582785	GNAS/PRKACB/CYP11A1/GNAQ/PRKACA/HSD3B1/ATF4	-0.179416057540235
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1076	56/9376	0.933616569304302	PRKACB/GSK3B/CUL1/PRKACA/GLI3/MGRN1	-0.179390102491253
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/1076	93/9376	0.936962865251629	ACTB/PDCD10/CCM2/CSNK2B/ACTG1/WASF2/CDC42/FER/CSNK2A2/MAPK3	-0.219961408257705
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1076	28/9376	0.933616569304302	ACOT4/THEM4/HADH	-0.126657842072072
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/1076	112/9376	0.933616569304302	MAPK13/IRAK1/MAPK8/CASP3/CHUK/AKT2/MAPK9/GNAI3/BAD/NFKBIB/MAPK3/AKT1	-0.254461544460272
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1076	38/9376	0.917237331246331	NADK/PNP/NUDT12/SIRT6	-0.184056889197859
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1076	48/9376	0.907682775712516	AKT2/ATP1B3/PIK3CB/HK1/AKT1	-0.230866976684822
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1076	29/9376	0.901422894500705	PAK1/RASSF1/LIMD1	-0.191421919650065
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/1076	115/9376	0.909261354452885	GNB2/GNB5/PRKACB/GNB1/GNAQ/AKT2/PIK3CB/GNAI3/PRKACA/MAPK3/ATF4/AKT1	-0.352504769925123
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1076	20/9376	0.871375464684015	EBP/SQLE	-0.207322500280854
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1076	20/9376	0.871375464684015	NANS/GMPPA	-0.207322500280854
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1076	69/9376	0.884004094606972	CALM1/GNAS/PRKACB/GNAQ/GNAI3/PRKACA/PPP3R1	-0.348189022787423
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/1076	69/9376	0.884004094606972	CALM1/GNAS/HDAC1/PRKACB/PRKACA/ATF4/PPP3R1	-0.348189022787423
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/1076	98/9376	0.889158637432668	CALM1/GNAS/PRKACB/CYP11A1/ATF1/GNAQ/ATP1B3/PRKACA/HSD3B1/ATF4	-0.397137079136888
NA	NA	hsa04981	Folate transport and metabolism	3/1076	31/9376	0.843266578726466	TYMS/MTHFS/ABCG2	-0.314706371365698
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/1076	155/9376	0.899484350641564	CCNE1/GNAS/PRKACB/CYP11A1/GNAQ/AIP/GSK3B/ARNT/GNAI3/MAP2K2/PRKACA/DVL3/HSD3B1/MAPK3/ATF4/CDK4	-0.454321456958793
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1076	21/9376	0.829881394937157	B4GALT7/DSEL	-0.280990923759154
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/1076	212/9376	0.904257557690959	CALM1/PGF/PFN1/GNAS/ACTB/RALA/RALB/MAPK13/SIPA1/GNAQ/AKT2/ENAH/TLN2/PIK3CB/ACTG1/EFNA4/CRK/GNAI3/MAP2K2/CDC42/MAPK3/AKT1	-0.507671308617924
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/1076	148/9376	0.883150808801366	SHC1/AKT2/GSK3B/PIK3CB/RPS6KB2/RPS6KB1/MAP2K2/DVL3/HEY2/PTEN/FRAT2/MAPK3/AKT1/BAX/CDK4	-0.515888091683359
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/1076	101/9376	0.862747984835658	CALM1/GNAS/PRKACB/GNAQ/GSK3B/GNAI3/MAP2K2/PRKACA/DVL3/MAPK3	-0.499315657685321
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1076	43/9376	0.810581827613037	ACADM/ECI2/GCDH/HADH	-0.448226949223803
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/1076	63/9376	0.829881394937157	DLD/SETD7/COLGALT1/GCDH/EHMT1/HADH	-0.487786766491413
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/1076	150/9376	0.871375464684015	CCNE1/SHC1/AKT2/GSK3B/PIK3CB/RPS6KB2/GAB1/RPS6KB1/MLH1/MAP2K2/DVL3/FRAT2/MAPK3/AKT1/BAX	-0.571762214093043
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/1076	93/9376	0.843266578726466	MAPK13/MAPK8/CHUK/GATA3/MAPK9/NFKBIB/MAML3/MAPK3/PPP3R1	-0.546904680899469
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/1076	34/9376	0.768860704132954	NFIL3/CUL1/PRKAB2	-0.486122855893679
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/1076	75/9376	0.813283767038414	CGA/GNAS/PRKACB/GNAQ/ATP1B3/PRKACA/ATF4	-0.584521666740304
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/1076	105/9376	0.829881394937157	TPM1/GNAS/ACTB/EMD/PRKACB/DAG1/ACTG1/LMNA/PRKACA/SNTA1	-0.631154814803823
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/1076	115/9376	0.833489574915145	NACA/GNAS/GCM1/PRKACB/GNA13/GNAQ/GATA3/GNAI3/PRKACA/MAPK3/ATF4	-0.646865717807021
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1076	66/9376	0.792159513349104	UGT2B7/CYP11A1/CYP19A1/HSD17B1/HSD3B1/SULT2B1	-0.61007047248229
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/1076	116/9376	0.82630431995898	ACTB/PTK2/MAPK13/MMP2/SIPA1/PIK3CB/ACTG1/GNAI3/JAM3/CDC42/F11R	-0.677743320772602
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/1076	116/9376	0.82630431995898	GNAS/GNB2/GNB5/PRKACB/GNB1/GNAQ/GNAI3/PRKACA/MAPK3/HOMER1/PPP3R1	-0.677743320772602
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1076	36/9376	0.726146220570012	UGT2B7/AKR1B1/AKR1A1	-0.592719586652613
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/1076	89/9376	0.783258844659789	GNB2/GNB5/PRKACB/GNB1/NSF/GNAI3/PRKACA/HAP1	-0.739692801487636
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/1076	99/9376	0.792159513349104	CALM1/GNAS/PRKACB/MAPK13/MAPK8/GNAQ/PIK3CB/MAPK9/PRKACA	-0.748508432391948
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1076	79/9376	0.772104842125076	MGST3/GSTP1/UGT2B7/AKR7A2/CBR1/GSTA4/GSTO1	-0.732369004323058
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1076	79/9376	0.772104842125076	ATP6V0D1/ATP6V1E1/ATP6V1A/NSF/CLTA/ATP6V1B1/AP2M1	-0.732369004323058
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	30/1076	300/9376	0.871375464684015	PGF/STMN1/IGF2/DUSP9/MKNK2/PRKACB/RPS6KA5/MAPK13/DUSP6/IRAK1/MAPK8/CASP3/CHUK/MAP3K13/MKNK1/PAK1/AKT2/MAPK9/EFNA4/CRK/MAP2K2/PPM1B/PRKACA/CDC42/MAPK3/ATF4/AKT1/PPP3R1/MAP2K7/ARTN	-0.81524835322977
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/1076	109/9376	0.799427031820197	HSP90AA1/MAPK13/MAPK8/CHUK/GATA3/MAPK9/HSP90AB1/NFKBIB/MAPK3/PPP3R1	-0.758348438045371
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/1076	38/9376	0.687927998434749	ATP1B3/PIK3CB/MAPK3	-0.694020657850082
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1076	70/9376	0.746893255443441	MGST3/GSTP1/UGT2B7/CBR1/GSTA4/GSTO1	-0.765286304990231
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/1076	70/9376	0.746893255443441	HLA-G/ACTB/CASP3/DAG1/ACTG1/SNTA1	-0.765286304990231
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1076	15/9376	0.58091697645601	ST6GALNAC4	-0.584840316036211
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/1076	50/9376	0.697100371747212	SAT2/P4HA1/CKB/SMS	-0.773194515188005
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/1076	134/9376	0.780336237030461	CALM1/GNAS/MYL6/PLA2G2A/CALD1/PRKACB/MYH9/GNA13/GNAQ/MAP2K2/PRKACA/MAPK3	-0.922105396789119
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/1076	144/9376	0.786658405617513	DUSP9/MAPK13/PCGF5/AKT2/GSK3B/PIK3CB/SMAD9/BMI1/MAP2K2/DVL3/MAPK3/MEIS1/AKT1	-0.928884278047418
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/1076	154/9376	0.792159513349104	CALM1/GNAS/MYL6/ACTB/PRKACB/EEF2/GNAQ/ACTG1/GNAI3/MAP2K2/PRKACA/PRKAB2/MAPK3/PPP3R1	-0.93633375436847
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/1076	104/9376	0.754074921361167	PLA2G2A/PCYT2/GNPAT/AGPAT1/PCYT1A/LPCAT2/ADPRM/PTDSS2/LYPLA1	-0.90799928133076
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1076	16/9376	0.544609665427509	GLA	-0.656384932787303
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	17/1076	184/9376	0.805075157588492	PTK2/RHOD/ILK/CFL1/CFL2/PAK1/ENAH/BMP7/GSK3B/PIK3CB/EFNA4/CDK5/GNAI3/CDC42/MAPK3/SRGAP2/PPP3R1	-0.961443622790318
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1076	29/9376	0.600948596333803	CALM1/GNB1	-0.774897835982643
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/1076	52/9376	0.670288818987704	VAPA/VDAC3/STARD3/MYLIP	-0.858394531127027
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1076	115/9376	0.757717795377404	GNAS/GNB2/GNB5/PRKACB/GNB1/CASP3/GNAQ/GNAI3/PRKACA/MAPK3	-0.941226665688919
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/1076	105/9376	0.746893255443441	BCL10/IRAK1/CHUK/CSNK2B/UBE2I/TICAM1/PIAS4/CSNK2A2/TRAF3	-0.939048027270037
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1076	17/9376	0.512573802755303	HSD3B7	-0.724221363647125
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1076	17/9376	0.512573802755303	CDO1	-0.724221363647125
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1076	42/9376	0.622411046202868	DLD/GCDH/HADH	-0.883004171565778
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/1076	86/9376	0.709259099161408	ACTB/EMD/DAG1/ACTG1/LMNA/SNTA1/DSC2	-0.97521467528141
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1076	54/9376	0.645463307173344	UBE2T/MLH1/RPA3/TELO2	-0.940711054418339
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1076	31/9376	0.562177719150977	UGT2B7/AKR1A1	-0.879107086347486
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/1076	149/9376	0.7602604725431	GNAS/RALA/RALB/SHC1/GNA13/AKT2/AGPAT1/PIK3CB/GAB1/PIP5K1C/MAP2K2/MAPK3/AKT1	-1.06207514763497
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/1076	98/9376	0.711326909946134	CALM1/IP6K2/PIK3CB/PIP5K1C/PIP4K2A/MTMR1/PTEN/PI4K2B	-1.03429608905945
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/1076	99/9376	0.704141789643648	TPM1/ACTB/EMD/DAG1/ACTG1/LMNA/SNTA1/PRKAB2	-1.06549194919894
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/1076	44/9376	0.594119635011828	ALG13/ALG3/FUT8	-0.971605004540069
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	18/1076	201/9376	0.780336237030461	HDAC1/PTK2/DUSP6/LMO2/ATF1/PRCC/FUS/FOXO1/BMI1/CCNA2/MDM2/TAF15/MYCN/TFE3/MEIS1/BAX/FUT8/ZBTB17	-1.13345984489125
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/1076	110/9376	0.712943562014194	HDAC1/PPP2R1A/BMP7/CUL1/RPS6KB2/SMAD9/RPS6KB1/ZFYVE9/MAPK3	-1.09036076034443
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/1076	56/9376	0.622411046202868	ALG13/DPM1/ALG3/FUT8	-1.02037090297025
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/1076	57/9376	0.611491554164221	ACADM/OXSM/CBR4/HADH	-1.05926827177525
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/1076	91/9376	0.670288818987704	GNAS/GNB2/GNB5/PRKACB/GNB1/GNAI3/PRKACA	-1.13793156587224
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/1076	103/9376	0.676796477424477	COL3A1/COL1A2/COL1A1/SLC3A2/DPP4/COL6A2/SLC36A4/ATP1B3	-1.18751005500788
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	14/1076	166/9376	0.734894970215434	CALM1/SLC25A5/GNA13/GNAQ/AKT2/ATP1B3/VDAC3/GNAI3/MAP2K2/BAD/MAPK3/ATF4/AKT1/PPP3R1	-1.24078039905546
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/1076	93/9376	0.65587400567614	CALM1/GNAS/PRKACB/CST1/GNAQ/ATP1B3/PRKACA	-1.200791226183
NA	NA	hsa03272	Virion - Hepatitis viruses	3/1076	48/9376	0.544609665427509	DPP4/CHMP4A/CHMP7	-1.13884045545868
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/1076	61/9376	0.57139374733378	HMOX2/SLC39A4/MT1F/ATP1B3	-1.20916263395916
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1076	49/9376	0.533495182459601	C1GALT1/COLGALT1/GALNT2	-1.17878855972997
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1076	73/9376	0.596832510057544	MGST3/GSTP1/UGT2B7/GSTA4/GSTO1	-1.24505389731903
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1076	37/9376	0.471013764694062	NIT2/GPT2	-1.16077427160497
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1076	37/9376	0.471013764694062	GSTZ1/HGD	-1.16077427160497
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1076	23/9376	0.378858897688702	GPT2	-1.0738198973361
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1076	23/9376	0.378858897688702	PREP	-1.0738198973361
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1076	86/9376	0.607936370709778	GNAS/PRKACB/GNAQ/ATP1B3/PRKACA/ATF4	-1.31507539470746
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/1076	63/9376	0.553254263291438	PTGDS/PLA2G2A/CBR1/PTGR1	-1.28096899379344
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/1076	63/9376	0.553254263291438	GSK3B/DVL3/GLI3/BAX	-1.28096899379344
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1076	38/9376	0.458618665623166	RFXANK/UNG	-1.2039844265023
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/1076	76/9376	0.573273332028957	ACADM/DBI/ILK/SLC27A2/PCK2	-1.34483137963533
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/1076	195/9376	0.714974740253551	HMGB1/SLC25A5/ACTB/GSDMD/HDAC1/MAPK13/AKT2/CASP4/PIK3CB/ACTG1/VDAC3/HAT1/MAP2K2/MAPK3/AKT1/HDAC3	-1.44813279808968
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1076	24/9376	0.363073110285006	B4GALT7	-1.12485277415089
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/1076	65/9376	0.536231055190163	AKR1B1/GLA/AKR1A1/AGPAT1	-1.35086797641018
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/1076	78/9376	0.558574015823086	MAPK13/IRAK1/EEF1A1/NFKBIB/MAPK3	-1.40949374223503
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1076	90/9376	0.58091697645601	GNAS/UGT2B7/PRKACB/ATP1B3/PRKACA/ABCG2	-1.43833388290662
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/1076	157/9376	0.66601946345275	ACTB/BIRC5/PPP2R2A/YWHAQ/PPP2R1A/TP53BP2/BMP7/GSK3B/RASSF1/ACTG1/DVL3/LIMD1	-1.51943387473458
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1076	26/9376	0.335144409493852	PLA2G2A	-1.22225246312794
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1076	26/9376	0.335144409493852	FOXA2	-1.22225246312794
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1076	27/9376	0.322731653586672	HADH	-1.26885737495513
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/1076	27/9376	0.322731653586672	ACOT4	-1.26885737495513
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/1076	43/9376	0.405290913806519	PLA2G2A/AGPAT1	-1.40728123400755
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1076	28/9376	0.311205523101434	B4GALT4	-1.31420176933982
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	10/1076	142/9376	0.613644693439447	MAPK13/MAPK8/CHUK/AKT2/PIK3CB/MAPK9/MAPK3/AKT1/PPP3R1/MAP2K7	-1.6702783289275
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/1076	45/9376	0.387277984304007	ABCA7/ABCG2	-1.4834003429622
NA	NA	hsa04081	Hormone signaling	17/1076	219/9376	0.676410178065217	CGA/LEP/GAST/IGF2/GNAS/GNB2/GNB5/DIO2/PRKACB/GNB1/GNA13/GNAQ/PIK3CB/SMAD9/GNAI3/PRKACA/STK11	-1.74458860312521
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1076	30/9376	0.290458488228005	PLA2G2A	-1.4014521548121
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/1076	31/9376	0.281088859575489	HIBCH	-1.44350780132927
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/1076	191/9376	0.63870452908776	CALM1/GNAS/GNB2/GNB5/HDAC1/PRKACB/SHC1/GNB1/GNAI3/HAT1/PRKACA/MAPK3/ATF4/HDAC3	-1.81631993014043
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/1076	89/9376	0.489536777912368	COL1A2/COL1A1/DAG1/COL6A2/HMMR	-1.74210555540189
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/1076	226/9376	0.655459420337533	CGA/CALM1/GNAS/PRKACB/MAPK8/PAK1/AKT2/ATP1B3/PIK3CB/MAPK9/GNAI3/MAP2K2/BAD/PRKACA/GLI3/MAPK3/AKT1	-1.88771653642939
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/1076	51/9376	0.341715868503535	PLA2G2A/LPCAT2	-1.69717560898865
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/1076	133/9376	0.524135617855046	HLA-G/SHC1/CASP3/PAK1/PIK3CB/MAP2K2/MAPK3/PPP3R1	-1.99001005713524
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1076	54/9376	0.322731653586672	CGA/HLA-G	-1.79703210745002
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/1076	157/9376	0.555016219543959	RAB7A/PTK2/MAPK13/CASP3/ARNT/CRK/MAP2K2/DNMT3A/DOCK1/MAPK3	-2.02443961771619
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/1076	55/9376	0.316863805339642	GLA/CERS5	-1.82940606533766
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1076	39/9376	0.223429606329235	HLA-G	-1.7496943163212
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/1076	102/9376	0.427144835629419	GNAS/RAB8A/PLA2G2A/GNAQ/ATP1B3	-2.09442156284026
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/1076	44/9376	0.198039878337276	HLA-G	-1.91974910555669
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1076	45/9376	0.193638992152003	HLA-G	-1.9522004513488
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/1076	95/9376	0.366894932498533	ATP6V0D1/ATP6V1E1/ATP6V1A/ATP6V1B1	-2.23302164978876
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1076	68/9376	0.256286901377651	UGT2B7/RDH10	-2.21607486157569
NA	NA	hsa04382	Cornified envelope formation	13/1076	217/9376	0.52202216778305	S100A11/KRT18/KRT19/KRT8/CAPN1/S100A16/KRT7/KRT23/PPP2R2A/PPP2R1A/PPP2R5E/PPP2R5C/PPP2R3B	-2.5648756842665
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/1076	168/9376	0.414940697468578	LEP/STAM/AKT2/SOCS6/PIK3CB/PIAS4/PIM1/AKT1	-2.75501902539108
NA	NA	hsa04519	Cadherin signaling	28/1076	404/9376	0.603923589384961	KRT18/KRT19/KRT8/ACTB/PTK2/KRT7/MAPK13/KRT23/MAPK8/YWHAQ/ARPC5L/CHUK/ENAH/GSK3B/ACTG1/MAPK9/ARPC5/LIMA1/MAP2K2/DSC2/DVL3/CDC42/ARPC1A/ARPC2/DAAM1/MAPK3/LIMD1/ARPC3	-2.93006837755349
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/1076	99/9376	0.264053171116368	KRT18/KRT19/KRT23	-2.65040953323393
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1076	86/9376	0.202645456903259	PRKACB/PRKACA	-2.67451827241167
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/1076	66/9376	0.132026585558184	GATA3	-2.5477468783068
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/1076	323/9376	0.512573802755303	CCNE1/TPM1/STMN1/HDAC1/RPS6KA5/SHC1/CASP3/RASSF1/PIK3CB/EFNA4/CRK/UBE2I/BMI1/MAP2K2/MDM2/DNMT3A/PTEN/MAPK3/PIM1	-3.20971591584634
NA	NA	hsa04082	Neuroactive ligand signaling	9/1076	199/9376	0.394089406138499	GNAS/GNB2/GNB5/PRKACB/GNB1/GNAQ/GNAI3/PRKACA/OGFRL1	-3.11055185616393
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/1076	100/9376	0.174275092936803	CCR7/TNFRSF1B	-2.98887493139067
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/1076	88/9376	0.099019939168638	TFPI	-3.05737098905518
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/1076	160/9376	0.217843866171004	HLA-G/PTPRS/JAM3/F11R	-3.59281571317113
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/1076	100/9376	0.0871375464684015	GYPA	-3.30428654849763
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/1076	254/9376	0.274448965254808	CALM1/SLC25A5/GNAS/PRKACB/GNAQ/VDAC3/PRKACA/PPP3R1	-4.22077807438199
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/1076	143/9376	0.0609353471807003	SNRPD1	-4.07422324512403
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	5/1076	298/9376	0.146203937027519	LEP/TNFSF12/CCR7/BMP7/TNFRSF1B	-5.39286959034787
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/1076	370/9376	0.0942027529388124	CGA/KISS1/LEP/OGFRL1	-6.40056945772479
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/1076	449/9376	0.0970351296975518	CALM1/PRKACB/GNB1/NCALD/PRKACA	-7.0598258038691